diff --git "a/bc2gm/train.json" "b/bc2gm/train.json" new file mode 100644--- /dev/null +++ "b/bc2gm/train.json" @@ -0,0 +1,96900 @@ +[ + { + "id": "0", + "type": "gene", + "text": "Immunohistochemical staining was positive for S - 100 in all 9 cases stained , positive for HMB - 45 in 9 ( 90 % ) of 10 , and negative for cytokeratin in all 9 cases in which myxoid melanoma remained in the block after previous sections .", + "entities": [ + "S - 100", + "HMB - 45", + "cytokeratin" + ] + }, + { + "id": "1", + "type": "gene", + "text": "Chloramphenicol acetyltransferase assays examining the ability of IE86 to repress activity from the HCMV major IE promoter or activate the HCMV early promoter for the 2 . 2 - kb class of RNAs demonstrated the functional integrity of the IE86 protein .", + "entities": [ + "Chloramphenicol acetyltransferase", + "IE86", + "IE promoter", + "HCMV early promoter", + "IE86 protein" + ] + }, + { + "id": "2", + "type": "gene", + "text": "A new DNA repair gene from Schizosaccharomyces pombe with homology to RecA was identified and characterized .", + "entities": [ + "DNA repair gene", + "RecA" + ] + }, + { + "id": "3", + "type": "gene", + "text": "Our study also demonstrated significant increases in the number of larger myelinated fibers crossing the repair site in comparison with the neonatal and adult groups ( p < 0 . 04 ) .", + "entities": [] + }, + { + "id": "4", + "type": "gene", + "text": "Cloning and sequencing of the upstream region of pepX revealed the presence of two ORFs of 360 and 1 , 338 bp that were shown to be able to encode proteins with high homology to GlnR and GlnA proteins , respectively .", + "entities": [ + "pepX", + "GlnR", + "GlnA proteins" + ] + }, + { + "id": "5", + "type": "gene", + "text": "Both mutant receptors were expressed on the cell surface and bound insulin normally , but showed markedly impaired autophosphorylation in response to insulin .", + "entities": [ + "insulin", + "insulin" + ] + }, + { + "id": "6", + "type": "gene", + "text": "Furthermore , analysis of the E2 proteins present in various cell lines harboring specific BPV - 1 mutants , including the 2558 acceptor mutant , proves that alternate modes of E2 expression exist .", + "entities": [ + "E2 proteins", + "E2" + ] + }, + { + "id": "7", + "type": "gene", + "text": "Molecular modelling suggested that the tetramerization domain was a four - helix bundle , stabilized by interactions of seven conserved aromatic amino acids .", + "entities": [] + }, + { + "id": "8", + "type": "gene", + "text": "Hematology problem of the month : band or seg ?", + "entities": [] + }, + { + "id": "9", + "type": "gene", + "text": "PKA phosphorylated WT1 at Ser - 365 and Ser - 393 in vitro , as well as at additional sites , and this phosphorylation abolished the DNA - binding activity of WT1 in vitro .", + "entities": [ + "PKA", + "WT1", + "WT1" + ] + }, + { + "id": "10", + "type": "gene", + "text": "ROCK - I , Kinectin , and mDia2 can bind the wild type forms of both RhoA and Cdc42 in a GTP - dependent manner in vitro .", + "entities": [ + "ROCK - I", + "Kinectin", + "mDia2", + "RhoA", + "Cdc42" + ] + }, + { + "id": "11", + "type": "gene", + "text": "These results support the hypothesis that in the presence of tryptophan the ribosome translating tnaC blocks Rho ' s access to the boxA and rut sites , thereby preventing transcription termination .", + "entities": [ + "tnaC", + "Rho", + "boxA", + "rut sites" + ] + }, + { + "id": "12", + "type": "gene", + "text": "Suppressors of defective silencing in yeast : effects on transcriptional repression at the HMR locus , cell growth and telomere structure .", + "entities": [ + "HMR locus" + ] + }, + { + "id": "13", + "type": "gene", + "text": "The pJR vectors differ among them in : ( a ) the selectable marker ( Saccharomyces cerevisiae LEU 2 gene , which complements S . pombe leu1 - gene and S . pombe ura4 + and his3 + genes ) ; ( b ) the thiamine - repressible nmt1 promoter ( 3X , 41X and 81X with extremely high , moderate or low transcription efficiency , respectively ) ; and ( c ) the multiple cloning site ( two multiple cloning sites , with 12 restriction sites each ) .", + "entities": [ + "LEU 2 gene", + "S . pombe leu1 - gene", + "ura4 +", + "his3 + genes", + "nmt1 promoter" + ] + }, + { + "id": "14", + "type": "gene", + "text": "The transcription of most RP genes is activated by two Rap1p binding sites , 250 to 400 bp upstream from the initiation of transcription .", + "entities": [ + "RP genes", + "Rap1p binding sites" + ] + }, + { + "id": "15", + "type": "gene", + "text": "Cardiac markers troponin T , CK - MB mass and myoglobin were helpful in the differential diagnosis of chest pain , even when the ECG was unremarkable or nonspecific .", + "entities": [ + "troponin T", + "CK", + "MB", + "myoglobin" + ] + }, + { + "id": "16", + "type": "gene", + "text": "Finally , in situ RNA hybridization studies revealed a very specific pattern of EphA8 gene expression restricted to the rostral region of midbrain tectum during embryonic development .", + "entities": [ + "EphA8 gene" + ] + }, + { + "id": "17", + "type": "gene", + "text": "None were restricted from clinical duties , were given varicella - zoster immune globulin , or developed disease .", + "entities": [ + "varicella - zoster immune globulin" + ] + }, + { + "id": "18", + "type": "gene", + "text": "Positional cloning has already produced the sequences of more than 70 human genes associated with specific diseases .", + "entities": [] + }, + { + "id": "19", + "type": "gene", + "text": "In this paper , we demonstrate that binding of the GA - binding protein ( GABP ) to ets sequence motifs within each repeated unit is required for transcriptional activation of the COXIV promoter .", + "entities": [ + "GA - binding protein", + "GABP", + "ets sequence motifs", + "COXIV promoter" + ] + }, + { + "id": "20", + "type": "gene", + "text": "These activities are all required for stimulation of cell growth by middle - T and activate members of the MAP kinase family .", + "entities": [ + "middle - T", + "MAP kinase family" + ] + }, + { + "id": "21", + "type": "gene", + "text": "HPLC phosphopeptide mapping , amino acid sequencing , and site - directed mutagenesis determined that NCLK phosphorylates Ser ( 67 ) of I - 1 .", + "entities": [ + "NCLK", + "I - 1" + ] + }, + { + "id": "22", + "type": "gene", + "text": "A chaotropic detergent , 0 . 1 % Nonidet P - 40 , also abolished the interaction , further supporting the hydrophobic nature of the interaction .", + "entities": [] + }, + { + "id": "23", + "type": "gene", + "text": "Genomic and cDNA clones homologous to the yeast GCN2 eIF - 2alpha kinase ( yGCN2 ) were isolated from Drosophila melanogaster .", + "entities": [ + "eIF - 2alpha" + ] + }, + { + "id": "24", + "type": "gene", + "text": "Overexpression of RORgamma has been shown to inhibit T cell receptor - mediated apoptosis in T cell hybridomas and to repress the induction of Fas - ligand and interleukin 2 .", + "entities": [ + "RORgamma", + "T cell receptor", + "Fas - ligand", + "interleukin 2" + ] + }, + { + "id": "25", + "type": "gene", + "text": "The final sigma54 - dependent DmpR activator regulates transcription of the dmp operon that encodes the enzymes for catabolism of ( methyl ) phenols .", + "entities": [ + "sigma54 - dependent DmpR activator", + "dmp operon" + ] + }, + { + "id": "26", + "type": "gene", + "text": "When tethered to a heterologous DNA - binding domain , PSU1 can activate transcription on its own .", + "entities": [ + "PSU1" + ] + }, + { + "id": "27", + "type": "gene", + "text": "The sorption mechanisms changed from adsorption to partition in the process of repetitious sorption .", + "entities": [] + }, + { + "id": "28", + "type": "gene", + "text": "Tyrosine 112 of latent membrane protein 2A is essential for protein tyrosine kinase loading and regulation of Epstein - Barr virus latency .", + "entities": [ + "latent membrane protein 2A", + "protein tyrosine kinase" + ] + }, + { + "id": "29", + "type": "gene", + "text": "Prognosis of asymptomatic multiple myeloma .", + "entities": [] + }, + { + "id": "30", + "type": "gene", + "text": "In contrast to behavioral deviation ( the avoidance conditioning lost ) , the haloperidol intrastriatal microinjections did not affect the DA synaptic level in rostral neostriatum .", + "entities": [] + }, + { + "id": "31", + "type": "gene", + "text": "From 250 g of cells , we isolated 1 mg of PDH complex with a specific activity of 12 . 6 U / mg of protein .", + "entities": [ + "PDH complex" + ] + }, + { + "id": "32", + "type": "gene", + "text": "Deletion of the proximal octanucleotide motif from the plasmid containing the - 461 fragment of the LPL promoter , resulted in a 79 and 76 % decrease in the level of expression in transfected 3T3 - L1 adipocytes and HepG2 hepatocytes , respectively .", + "entities": [ + "LPL promoter" + ] + }, + { + "id": "33", + "type": "gene", + "text": "The fragments of each region were amplified by polymerase chain reaction and analyzed by gel electrophoresis to detect single - strand conformation polymorphism .", + "entities": [] + }, + { + "id": "34", + "type": "gene", + "text": "A third prominent component of apparent molecular mass 16 kDa displayed several properties , including ability to bind 45Ca2 + , that are characteristic of the regulatory ( B ) subunit of mammalian calcineurin and was recognized by an antiserum raised against bovine calcineurin .", + "entities": [ + "mammalian calcineurin", + "bovine calcineurin" + ] + }, + { + "id": "35", + "type": "gene", + "text": "Elimination of ETH1 in apn1 strains also increased spontaneous mutation rates 9 - or 31 - fold compared to the wild type as determined by reversion to adenine or lysine prototrophy , respectively .", + "entities": [ + "ETH1", + "apn1" + ] + }, + { + "id": "36", + "type": "gene", + "text": "With the help of a nomogram one can read off the refraction , when axis length and corneal curvature are known .", + "entities": [] + }, + { + "id": "37", + "type": "gene", + "text": "A direct role for sterol regulatory element binding protein in activation of 3 - hydroxy - 3 - methylglutaryl coenzyme A reductase gene .", + "entities": [ + "sterol regulatory element binding protein", + "3 - hydroxy - 3 - methylglutaryl coenzyme A reductase gene" + ] + }, + { + "id": "38", + "type": "gene", + "text": "We have identified three binding sites for protein complexes : a palindrome , a direct repeat , and a C + T sequence that corresponds to seven GAGA motifs on the transcribed strand .", + "entities": [] + }, + { + "id": "39", + "type": "gene", + "text": "Modification of dopamine D2 receptor activity by pergolide in Parkinson ' s disease : an in vivo study by PET .", + "entities": [ + "dopamine D2 receptor" + ] + }, + { + "id": "40", + "type": "gene", + "text": "In the p51 subunit , the Cys181 side - chain is oriented in a similar direction to the Tyr181 side - chain in the wild - type complex .", + "entities": [ + "p51 subunit" + ] + }, + { + "id": "41", + "type": "gene", + "text": "Expense limits the use of hepatitis B vaccines , but low - dose intradermal immunization has been evaluated as a cost - saving strategy in numerous studies .", + "entities": [] + }, + { + "id": "42", + "type": "gene", + "text": "Blood flow velocity waveforms were recorded by pulsed Doppler examination of the fetal internal carotid and middle cerebral arteries using the established transabdominal route as well as a new transvaginal approach .", + "entities": [] + }, + { + "id": "43", + "type": "gene", + "text": "Expansins are a family of proteins that catalyse long - term extension of isolated plant cell walls due to an as yet unknown biochemical mechanism .", + "entities": [ + "Expansins" + ] + }, + { + "id": "44", + "type": "gene", + "text": "The cglIM gene is organized in an unusual operon which contains , in addition , two genes encoding stress - sensitive restriction enzymes .", + "entities": [ + "cglIM gene" + ] + }, + { + "id": "45", + "type": "gene", + "text": "A soap and water ( 1 : 1 , v / v ) solution effectively decontaminated powdered stratum corneum .", + "entities": [] + }, + { + "id": "46", + "type": "gene", + "text": "Srb10 is a physiological regulator of Gcn4 stability because both phosphorylation and turnover of Gcn4 are diminished in srb10 mutants .", + "entities": [ + "Srb10", + "Gcn4", + "Gcn4", + "srb10 mutants" + ] + }, + { + "id": "47", + "type": "gene", + "text": "Ongoing and future investigations may better define the optimal approach for local control , the optimal duration of maintenance chemotherapy , and the possible role of biologic response modifiers and growth factors in further improving the outcome for patients with this disease .", + "entities": [] + }, + { + "id": "48", + "type": "gene", + "text": "Sulphur amino acids ( g / 16 g N ) were higher in the isolates than in the flours .", + "entities": [] + }, + { + "id": "49", + "type": "gene", + "text": "These characteristic structural features were used to create the abbreviation AZF1 ( Asparagine - rich Zinc Finger protein ) .", + "entities": [ + "AZF1", + "Asparagine - rich Zinc Finger protein" + ] + }, + { + "id": "50", + "type": "gene", + "text": "A prostaglandin analogue given in early pregnancy and human chorionic gonadotropin given near the end of the ensuing follicular phase were used for controlling the reproductive cycle , timing oocyte collection , and synchronizing the cycles of oocyte donors and embryo recipients .", + "entities": [ + "human chorionic gonadotropin" + ] + }, + { + "id": "51", + "type": "gene", + "text": "High levels of serum calcitonin were found in patients with chronic renal failure .", + "entities": [ + "calcitonin" + ] + }, + { + "id": "52", + "type": "gene", + "text": "By using space - discrete / continuous metapopulation dynamic models and computer simulations , we show that there can be two principally different regimes of metapopulation dynamics .", + "entities": [] + }, + { + "id": "53", + "type": "gene", + "text": "Proliferative vasculopathy and cutaneous hemorrhages in porcine neonates infected with the porcine reproductive and respiratory syndrome virus .", + "entities": [] + }, + { + "id": "54", + "type": "gene", + "text": "No patient with bradyarrhythmia - related SCD had manifest atrioventricular block or bundle branch block .", + "entities": [] + }, + { + "id": "55", + "type": "gene", + "text": "While no significant differences in the tensile responses or failure characteristics were noted for irradiated and nonirradiated grafts in the drip , in the bath environment the nonirradiated tissues had greater strength and modulus .", + "entities": [] + }, + { + "id": "56", + "type": "gene", + "text": "The proposed mechanism of effect states that mono ( 2 - ethylhexyl ) phthalate ( MEHP ) , the primary hydrolysis product of DEHP , mimics the inducing prostaglandins ( PG ) PGD ( 2 ) , 9alpha , 11betaPGF2 , and PGF2alpha , and thromboxanes in the lungs , thereby increasing the risk of inducing inflammation in the airways , which is a characteristic of asthma .", + "entities": [] + }, + { + "id": "57", + "type": "gene", + "text": "Processing of the NS3 ' - 5B polyprotein was complex and occurred rapidly .", + "entities": [ + "NS3 '", + "5B" + ] + }, + { + "id": "58", + "type": "gene", + "text": "Application of the method to a representative set of 50 known genes from Arabidopsis thaliana showed significant improvement in prediction accuracy compared to previous spliced alignment methods .", + "entities": [] + }, + { + "id": "59", + "type": "gene", + "text": "Vocal cord abduction rehabilitation by nervous selective anastomosis .", + "entities": [] + }, + { + "id": "60", + "type": "gene", + "text": "Plethysmographic technique and indirect blood pressure recordings were used .", + "entities": [] + }, + { + "id": "61", + "type": "gene", + "text": "Bone marrow abnormalities in Hodgkin ' s disease are reviewed and the current understanding of the pathological mechanisms leading to aplastic anemia is discussed .", + "entities": [] + }, + { + "id": "62", + "type": "gene", + "text": "Detection of anti - lymphocyte antibodies using the immunoperoxidase antiglobulin technic .", + "entities": [ + "antiglobulin" + ] + }, + { + "id": "63", + "type": "gene", + "text": "The mean values of the concentrations of the components due to tobacco smoke are : CO = 1 . 1 ppm , NO = 32 ppb , NO2 = 24 ppb , nicotine = 0 . 9 micrograms / m3 , particulate matter = 133 micrograms / m3 .", + "entities": [] + }, + { + "id": "64", + "type": "gene", + "text": "Infection with Neisseria meningitidis group B has been difficult to detect , partly because this bacterial group ' s polysaccharide is a weak immunogen .", + "entities": [] + }, + { + "id": "65", + "type": "gene", + "text": "Laser ablation has been employed as a therapeutic measure for chronic pulmonary emphysema .", + "entities": [] + }, + { + "id": "66", + "type": "gene", + "text": "The drug sensitivity was 100 % for vancomycin ( VCM ) , 30 % for imipenam ( IMP ) , 31 % for minomycin ( MINO ) , 31 % for amikacin ( AMK ) , and 7 % for fosfomycin ( FOM ) .", + "entities": [] + }, + { + "id": "67", + "type": "gene", + "text": "Glomerular hemodynamics during abortion induced by RU 486 and sepsis in rats .", + "entities": [] + }, + { + "id": "68", + "type": "gene", + "text": "Intravenous glucose tolerance tests were performed before operation , before starting CyA and after 3 weeks .", + "entities": [] + }, + { + "id": "69", + "type": "gene", + "text": "Pharmacologic aspects of neonatal hyperbilirubinemia .", + "entities": [] + }, + { + "id": "70", + "type": "gene", + "text": "DNA - dependent protein kinase ( DNA - PK ) consists of a heterodimeric protein ( Ku ) and a large catalytic subunit ( DNA - PKcs ) .", + "entities": [ + "DNA - dependent protein kinase", + "DNA - PK", + "Ku", + "DNA - PKcs" + ] + }, + { + "id": "71", + "type": "gene", + "text": "Serodiagnosis of ectromelia in laboratory mice", + "entities": [] + }, + { + "id": "72", + "type": "gene", + "text": "No mutation of the NRL gene was found in any of the two families .", + "entities": [ + "NRL gene" + ] + }, + { + "id": "73", + "type": "gene", + "text": "Ten out - patients with pustulosis palmaris et plantaris were examined with direct immunofluorescence ( IF ) technique for deposition of fibrinogen , fibrin or its degradation products ( FR - antigen ) in affected and unaffected skin , together with heparin - precipitable fraction ( HPF ) , cryoglobulin and total plasma fibrinogen in the blood .", + "entities": [ + "fibrinogen", + "fibrin", + "FR - antigen", + "cryoglobulin", + "fibrinogen" + ] + }, + { + "id": "74", + "type": "gene", + "text": "In addition , we show that the expression of individual members of one subfamily of KRAB zinc finger genes is restricted to specific hematopoietic cell lineages .", + "entities": [ + "KRAB zinc finger genes" + ] + }, + { + "id": "75", + "type": "gene", + "text": "We recently reported a placenta - specific enhancer in the human leukemia inhibitory factor receptor ( LIFR ) gene and now show detailed characterization of the 226 - base pair enhancer ( - 4625 / - 4400 nucleotides ) .", + "entities": [ + "human leukemia inhibitory factor receptor", + "LIFR" + ] + }, + { + "id": "76", + "type": "gene", + "text": "Despite continuous compliance , unexplained resurgence of serum ferritin levels occurred in 4 / 7 patients of the ' veteran ' group after 4 - 5 years on L1 .", + "entities": [ + "ferritin" + ] + }, + { + "id": "77", + "type": "gene", + "text": "Initial screening of a rat liver cDNA library with an oligonucleotide probe derived from the rat SCP2 protein sequence revealed an 825 - base pair cDNA clone coding for the complete SCP2 protein sequence .", + "entities": [ + "SCP2", + "SCP2" + ] + }, + { + "id": "78", + "type": "gene", + "text": "The UAS of the AAC2 gene contains at least two distinct motifs for DNA - binding transcriptional activators , including one which is identical with the core HAP2 / 3 / 4 binding motif , and a second one with the ABF1 consensus binding sequence .", + "entities": [ + "AAC2 gene", + "HAP2 / 3 / 4 binding motif", + "ABF1 consensus binding sequence" + ] + }, + { + "id": "79", + "type": "gene", + "text": "Causes of death found in an epidemiological study of native chickens in Thai villages .", + "entities": [] + }, + { + "id": "80", + "type": "gene", + "text": "Simultaneously a greater NA was found with no change in plasma epinephrine response .", + "entities": [] + }, + { + "id": "81", + "type": "gene", + "text": "A genomic DNA clone encoding oryzacystatin ( Oc ) , a cysteine proteinase inhibitor ( cystatin ) of rice , was isolated from a lambda EMBL3 phage library constructed with Sau3AI partial digests of rice chromosomal DNA , by screening with an oc cDNA as a probe .", + "entities": [ + "oryzacystatin", + "Oc", + "cysteine proteinase", + "cystatin", + "Sau3AI", + "oc cDNA" + ] + }, + { + "id": "82", + "type": "gene", + "text": "The effect of the opiate antagonist naloxone was evaluated in 11 unselected patients with cerebral ischemia .", + "entities": [] + }, + { + "id": "83", + "type": "gene", + "text": "Neither side effect nor abnormal laboratory findings due to this drug were observed .", + "entities": [] + }, + { + "id": "84", + "type": "gene", + "text": "The effects of a 1 - or 24 - hour pretreatment regimen with monophosphoryl lipid A ( MLA , 35 micrograms / kg i . v . ) on myocardial stunning produced by repetitive coronary occlusions were studied in barbital - anesthetized dogs .", + "entities": [] + }, + { + "id": "85", + "type": "gene", + "text": "Transient cotransfection of tat cDNA in sense orientation ( tat / S ) , together with a plasmid containing the c - fos promoter ( FC3 , from - 711 to + 42 ) in front of the bacterial chloramphenicol acetyltransferase ( CAT ) gene significantly enhanced CAT activity in Jurkat cells activated by the addition of 15 % fetal calf serum ( FCS ) or 5 micrograms / mL phytohemagglutinin plus 10 ( - 7 ) mol / L phorbol myristate acetate ( PMA ) and U937 cells activated by 15 % FCS or 10 ( - 7 ) mol / L PMA .", + "entities": [ + "tat cDNA", + "tat / S", + "c - fos promoter", + "FC3", + "bacterial chloramphenicol acetyltransferase", + "CAT", + "CAT", + "phytohemagglutinin" + ] + }, + { + "id": "86", + "type": "gene", + "text": "Therefore , it is hoped that by defining the transcriptional control of the L7 gene insights into the mechanisms that control functional fate and organization in the nervous system can be gained .", + "entities": [ + "L7 gene" + ] + }, + { + "id": "87", + "type": "gene", + "text": "These results suggest that dietary safflower phospholipids may be a valuable ingredient to layers for reducing liver triglycerides and serum cholesterol without any adverse effects .", + "entities": [] + }, + { + "id": "88", + "type": "gene", + "text": "However , a similar mutation of a leucine residue to arginine at position 422 showed no alteration of heterodimerization , DNA binding , or transcriptional activation .", + "entities": [] + }, + { + "id": "89", + "type": "gene", + "text": "The cleavage dipeptides of C1YVV NIa protease are Q ( E ) / S ( A , G ) .", + "entities": [ + "C1YVV NIa protease" + ] + }, + { + "id": "90", + "type": "gene", + "text": "In contrast , similar rates of B . sphaericus products , ABG - 6184 technical powder and BSP - 2 flowable concentrate , produced no significant reduction .", + "entities": [] + }, + { + "id": "91", + "type": "gene", + "text": "It was concluded that Scotchbond 2 and Prisma Universal Bond 2 are effective and are the dentine bonding agents of choice .", + "entities": [] + }, + { + "id": "92", + "type": "gene", + "text": "The major findings of our studies are as follows : 1 ) There are no detectable signals around GDF - 9 - deficient follicles for several theca cell layer markers [ i . e .", + "entities": [ + "GDF - 9" + ] + }, + { + "id": "93", + "type": "gene", + "text": "Here we report that Dbp5p and Rat7p interact through their Nterminal domains .", + "entities": [ + "Dbp5p", + "Rat7p" + ] + }, + { + "id": "94", + "type": "gene", + "text": "Regulation of the alpha inhibin gene by cyclic adenosine 3 ' , 5 ' - monophosphate after transfection into rat granulosa cells .", + "entities": [ + "alpha inhibin gene" + ] + }, + { + "id": "95", + "type": "gene", + "text": "Thus , phosphodiesterase inhibitors that produce an opiate quasi - withdrawal syndrome potentiate interoceptive stimuli and weight loss associated with the withdrawal syndrome precipitated by naltrexone in morphine - dependent rats .", + "entities": [] + }, + { + "id": "96", + "type": "gene", + "text": "A limited study in a glassware factory ( As2O3 exposure ) involving the measurement of total airborne arsenic , the determination of urinary arsenic , and the evaluation of hand and mouth contamination by arsenic before and after the workshift suggests that the high urinary arsenic levels ( 300 microgram / g creatinine ) are likely to be more related to an increased oral intake from contaminated hands than to an increased absorption from the lungs .", + "entities": [] + }, + { + "id": "97", + "type": "gene", + "text": "Both of these domains have striking sequence homology with human SIM and Drosophila SIM proteins .", + "entities": [ + "SIM", + "SIM" + ] + }, + { + "id": "98", + "type": "gene", + "text": "The 60A transcripts and protein are first detected at the onset of gastrulation , primarily in the mesoderm of the extending germ band .", + "entities": [ + "60A transcripts" + ] + }, + { + "id": "99", + "type": "gene", + "text": "OBJECTIVES : To measure coagulation factor VIII : coagulant ( F . VIII : C ) and C1 - esterase inhibitor ( C1 - INH ) , hemostasis - associated acute - phase reactant proteins and coagulation factors VII ( F . VII ) , IX ( F . IX ) , and X ( F . X ) , hemostasis proteins not associated with an acute - phase response , in a select population of horses with colic and hemostasis abnormalities , and presumed to have acute - phase changes .", + "entities": [ + "coagulation factor VIII : coagulant", + "F . VIII : C", + "C1 - esterase inhibitor", + "C1 - INH", + "coagulation factors VII", + "F . VII", + "F . IX", + "F . X" + ] + }, + { + "id": "100", + "type": "gene", + "text": "Peroxydase reaction stains were negative , chloroacetate esterase were strongly positive .", + "entities": [ + "Peroxydase", + "chloroacetate esterase" + ] + }, + { + "id": "101", + "type": "gene", + "text": "This difference may result from the lower match to the ARG box consensus of the O ( rocD ) site .", + "entities": [ + "O ( rocD ) site" + ] + }, + { + "id": "102", + "type": "gene", + "text": "Intrastriatal grafts of nigral and adrenal tissues have been found to be effective in alleviating many of the simple motor and sensorimotor deficits associated with lesions of the nigrostriatal dopamine system .", + "entities": [] + }, + { + "id": "103", + "type": "gene", + "text": "Copyright 2000 Academic Press .", + "entities": [] + }, + { + "id": "104", + "type": "gene", + "text": "We report a case of pheochromocytoma manifesting during the third trimester of pregnancy .", + "entities": [] + }, + { + "id": "105", + "type": "gene", + "text": "Although the E - box consensus is minimally defined as CANNTG , the adjacent nucleotides of functional E - boxes are variable for genes regulated by the bHLH proteins .", + "entities": [ + "bHLH proteins" + ] + }, + { + "id": "106", + "type": "gene", + "text": "Here is presented the monitoring of the accidental spill on vertical distribution of heavy metals in the estuarine sediments .", + "entities": [] + }, + { + "id": "107", + "type": "gene", + "text": "Among the mixed race persons one Chukcha - Eskimo had AS , one Eskimo - Russian had psoriatic arthritis ( PsA ) .", + "entities": [] + }, + { + "id": "108", + "type": "gene", + "text": "VE - DEF animals had significantly higher ( p < 0 . 05 ) levels of myocardial lipid peroxidation and lower ( p < 0 . 05 ) protein thiols following I - R compared to the CON animals .", + "entities": [] + }, + { + "id": "109", + "type": "gene", + "text": "Only seven patients , five of whom have metastatic disease , survive more than 10 years after first presentation ; nine patients , one of whom has secondaries , survive for 5 years or less .", + "entities": [] + }, + { + "id": "110", + "type": "gene", + "text": "The ORs of GC , adjusted for age and sex , varied from 17 . 1 , for those with baseline diagnoses of superficial intestinal metaplasia ( IM ) , to 29 . 3 , for those with deep IM or mild dysplasia ( DYS ) or IM with glandular atrophy and neck hyperplasia , to 104 . 2 , for those with moderate or severe DYS , as compared with subjects with superficial gastritis ( SG ) or chronic atrophic gastritis ( CAG ) at baseline .", + "entities": [] + }, + { + "id": "111", + "type": "gene", + "text": "We consider that DIL - CP is a safe and excellent CP in CABG surgery and we are now utilizing this CP in all patients requiring CABG surgery .", + "entities": [] + }, + { + "id": "112", + "type": "gene", + "text": "During 1985 , 1990 , and 1995 , respectively , 11 . 7 , 11 . 3 , and 11 . 4 infants per 100 , 000 live births had a diagnosis of HSV ( P = . 98 ) .", + "entities": [] + }, + { + "id": "113", + "type": "gene", + "text": "Cerebral125 albumin was increased to similar proportions in those groups submitted to hyperosmolality .", + "entities": [ + "Cerebral125 albumin" + ] + }, + { + "id": "114", + "type": "gene", + "text": "These data suggest that the function of the DS2 may be the protection of the nuclear DNA from desiccation .", + "entities": [ + "DS2" + ] + }, + { + "id": "115", + "type": "gene", + "text": "In situ hybridization with the antisense RNA probes further supported the expression changes of these six clones and localized the changes in multiple germ cell stages as well as other cell types ( Sertoli , interstitial and peritubular cells ) .", + "entities": [] + }, + { + "id": "116", + "type": "gene", + "text": "R - wave voltage in the right precordial leads in anthracycline cardiomyopathy : a clinical study .", + "entities": [] + }, + { + "id": "117", + "type": "gene", + "text": "Limb allografts in rats immunosuppressed with cyclosporin A .", + "entities": [] + }, + { + "id": "118", + "type": "gene", + "text": "Mutations at three sites have larger effects in muscle than nonmuscle cells ; an A / T - rich site mutation has a pronounced effect in both striated muscle types , mutations at the MEF1 ( Right E - box ) site are relatively specific to expression in skeletal muscle , and mutations at the CArG site are relatively specific to expression in cardiac muscle .", + "entities": [ + "MEF1 ( Right E - box ) site" + ] + }, + { + "id": "119", + "type": "gene", + "text": "The monkey LHR cDNA displayed 83 - 94 % overall sequence homology with the other mammalian LHR cDNAs .", + "entities": [ + "monkey LHR cDNA", + "mammalian LHR cDNAs" + ] + }, + { + "id": "120", + "type": "gene", + "text": "Alanine substitution mutations in the Zta activation domain which eliminate the ability of Zta to stimulate the D - A complex were examined .", + "entities": [ + "Zta activation domain", + "Zta", + "D - A complex" + ] + }, + { + "id": "121", + "type": "gene", + "text": "In contrast with previous two - pool models , provisions were made for folate turnover by urinary folate excretion ( as measured here ) and by fecal excretion and catabolic processes .", + "entities": [] + }, + { + "id": "122", + "type": "gene", + "text": "In female Sl ( pan ) / Sl ( pan ) mice , ovarian follicle development is arrested at the one layered cuboidal stage as a result of reduced KL expression in follicle cells , indicating a role for c - kit in oocyte growth .", + "entities": [ + "Sl ( pan ) / Sl ( pan )", + "KL", + "c - kit" + ] + }, + { + "id": "123", + "type": "gene", + "text": "Among genes induced by added pMesogenin1 is Xwnt - 8 , a signaling factor that induces a similar repertoire of marker genes and a similar cellular phenotype .", + "entities": [ + "pMesogenin1", + "Xwnt - 8" + ] + }, + { + "id": "124", + "type": "gene", + "text": "The hemodynamics of isoproterenol - induced cardiac failure in the rat .", + "entities": [] + }, + { + "id": "125", + "type": "gene", + "text": "BACKGROUND : Fluoroquinolones ( FQ ) are contraindicated in children because of the risk of cartilage damage .", + "entities": [] + }, + { + "id": "126", + "type": "gene", + "text": "In patients in group A ( \" normal \" CI ) , the CI , heart rate and the mean circumferential fiber shortening velocity ( mVCF ) were normal , but the TPR was increased significantly .", + "entities": [] + }, + { + "id": "127", + "type": "gene", + "text": "Clinical use of absorbable polyglycolic acid suture in Blalock - Taussig ' s operation", + "entities": [] + }, + { + "id": "128", + "type": "gene", + "text": "A novel approach was developed for identifying transcription factor activities associated with NGF - activated , but not EGF - activated , signaling , using random oligonucleotide clones from a DNA recognition library to isolate specific DNA binding proteins from PC12 nuclear extracts .", + "entities": [ + "NGF", + "EGF" + ] + }, + { + "id": "129", + "type": "gene", + "text": "D .", + "entities": [] + }, + { + "id": "130", + "type": "gene", + "text": "Disciplinary action for DNA violation .", + "entities": [] + }, + { + "id": "131", + "type": "gene", + "text": "Since 1970 the frequency of potassium - induced ulceration has been low - - 3 cases per 100 000 patient - years of slow - release tablet use .", + "entities": [] + }, + { + "id": "132", + "type": "gene", + "text": "Tl - 201 uptake ratio of the right ventricle , which represents the ratio of total counts of the right ventricle to counts of the administered dose of Tl - 201 , was higher in COPD , especially in pulmonary emphysema and B type COPD by Burrows classification than in controls .", + "entities": [] + }, + { + "id": "133", + "type": "gene", + "text": "The deubiquitinating enzyme DUB - 2 is induced in response to IL - 2 but as yet its function has not been determined .", + "entities": [ + "DUB - 2", + "IL - 2" + ] + }, + { + "id": "134", + "type": "gene", + "text": "The bovine papillomavirus E2 protein can inhibit the proliferation of HT - 3 cells , a p53 - negative cervical carcinoma cell line containing integrated human papillomavirus type 30 DNA .", + "entities": [ + "bovine papillomavirus E2 protein", + "p53" + ] + }, + { + "id": "135", + "type": "gene", + "text": "A much less expensive solution than UW , containing only K ( + ) - lactobionate , KH2PO4 , MgSO4 and raffinose , can be used successfully for preservation of rat hepatocytes for 24 hr for drug transport studies .", + "entities": [] + }, + { + "id": "136", + "type": "gene", + "text": "Hydroxypropyl methacrylate , a new water - miscible embedding medium for electron microscopy .", + "entities": [] + }, + { + "id": "137", + "type": "gene", + "text": "The homologous active - site framework of these enzymes with distinct structures suggests convergent evolution of a common catalytic mechanism .", + "entities": [] + }, + { + "id": "138", + "type": "gene", + "text": "Large strain differences were found for all variables recorded , i . e . , the proportion of attacking males , the time spent in the brightly lit box , and the number of transitions between the lit and the dark boxes .", + "entities": [] + }, + { + "id": "139", + "type": "gene", + "text": "In gel mobility shift assays , factors present in nuclear extracts derived from differentiated osteoblast bound to oligonucleotide probes containing the E - box 1 and E - box 2 elements .", + "entities": [] + }, + { + "id": "140", + "type": "gene", + "text": "Here we describe and map two more new genes identified as allele - specific suppressors that compensate for carboxy - terminal truncation of PET122 .", + "entities": [ + "PET122" + ] + }, + { + "id": "141", + "type": "gene", + "text": "One of these fragments shows the highest amino acid sequence homology to the insect ecdysone inducible gene E75 .", + "entities": [ + "gene E75" + ] + }, + { + "id": "142", + "type": "gene", + "text": "Secretory function of the prostate gland .", + "entities": [] + }, + { + "id": "143", + "type": "gene", + "text": "Changes of plasma cortisol level in late asthmatic responses", + "entities": [] + }, + { + "id": "144", + "type": "gene", + "text": "We find that the measured Nusselt number decreased about 20 % over the range of Pr spanned in the experiment .", + "entities": [] + }, + { + "id": "145", + "type": "gene", + "text": "An NF1 - related vitellogenin activator element mediates transcription from the estrogen - regulated Xenopus laevis vitellogenin promoter .", + "entities": [ + "NF1 - related vitellogenin activator element", + "Xenopus laevis vitellogenin promoter" + ] + }, + { + "id": "146", + "type": "gene", + "text": "Perhaps in addition to , or as part of , its essential function in late mitosis , MOB1 is required for a cell cycle reset function necessary for the initiation of the spindle pole body duplication .", + "entities": [ + "MOB1" + ] + }, + { + "id": "147", + "type": "gene", + "text": "DR1 molecules purified from human lymphoblastoid cell lines could specifically bind to these peptide sequences expressed on the phage surface .", + "entities": [ + "DR1 molecules" + ] + }, + { + "id": "148", + "type": "gene", + "text": "Sixty - five patients ( aged between 3 years 5 months and 60 years ) suffering from medically resistant temporal lobe epilepsy ( TLE ) were operated on over a period of 33 months in Bethel Epilepsy Center .", + "entities": [] + }, + { + "id": "149", + "type": "gene", + "text": "Diagnosis and treatment planning in Class II , division 2", + "entities": [] + }, + { + "id": "150", + "type": "gene", + "text": "The 3 ' UTR has several stable hairpins that are flanked by single - stranded ( A / U ) UGC sequences .", + "entities": [] + }, + { + "id": "151", + "type": "gene", + "text": "AIMS : To evaluate the role of environmental intra - uterine factors in determining the birthweights of twins with increased susceptibility to diabetes and discordant for abnormal responses to the oral glucose tolerance test ( OGTT ) and verify the possible association of within - pair birthweight differences and metabolic abnormalities in adult life .", + "entities": [] + }, + { + "id": "152", + "type": "gene", + "text": "Restriction enzyme mapping and Southern analysis indicated further that the human MZF - 1 gene is a single - copy gene .", + "entities": [ + "human MZF - 1 gene" + ] + }, + { + "id": "153", + "type": "gene", + "text": "Responses of single - unit carotid body chemoreceptors in adult rats .", + "entities": [] + }, + { + "id": "154", + "type": "gene", + "text": "Tec kinase signaling in T cells is regulated by phosphatidylinositol 3 - kinase and the Tec pleckstrin homology domain .", + "entities": [ + "Tec kinase", + "phosphatidylinositol 3 - kinase", + "pleckstrin homology domain" + ] + }, + { + "id": "155", + "type": "gene", + "text": "An analytic method for comparative parameter weighting in magnetic resonance ( MR ) imaging has been developed using the concept of \" fractional sensitivity . \" This new approach results in easily calculated indexes for T1 , T2 , and hydrogen weighting .", + "entities": [] + }, + { + "id": "156", + "type": "gene", + "text": "Spatial accuracy of primary and secondary memory - guided saccades in schizophrenic patients .", + "entities": [] + }, + { + "id": "157", + "type": "gene", + "text": "In the context of liver allograft shortage , our results suggest that an ELT should not be performed in patients with cardiac failure , more than two OSF , or an APACHE II score higher than 30 .", + "entities": [] + }, + { + "id": "158", + "type": "gene", + "text": "In one , exploratory behavior ( assessed by hole pokes ) and locomotion were assessed during a 10 - min test session .", + "entities": [] + }, + { + "id": "159", + "type": "gene", + "text": "Analysis of the inferred 1 , 859 - residue ama - 1 product showed considerable identity with the largest subunit of RNAP II from other organisms , including the presence of a zinc finger motif near the amino terminus , and a carboxyl - terminal domain of 42 tandemly reiterated heptamers with the consensus Tyr Ser Pro Thr Ser Pro Ser .", + "entities": [ + "1 , 859 - residue ama - 1 product", + "RNAP II" + ] + }, + { + "id": "160", + "type": "gene", + "text": "In these cases , greatly increased human chorionic gonadotropin ( hCG ) levels and suppressed TSH levels suggest that hCG has thyrotropic activity .", + "entities": [ + "human chorionic gonadotropin", + "hCG", + "TSH", + "hCG" + ] + }, + { + "id": "161", + "type": "gene", + "text": "Bipolarity in Jungian type theory and the Myers - Briggs Type Indicator .", + "entities": [] + }, + { + "id": "162", + "type": "gene", + "text": "The present results demonstrate that rats with relatively small remnants of one olfactory bulb can perform a variety of odor detection and discrimination tasks as well or nearly as well as controls .", + "entities": [] + }, + { + "id": "163", + "type": "gene", + "text": "The SR protein family is involved in constitutive and regulated pre - mRNA splicing and has been found to be evolutionarily conserved in metazoan organisms .", + "entities": [ + "SR protein family" + ] + }, + { + "id": "164", + "type": "gene", + "text": "Another tentative hotspot mutation in the third patient , a frame shift caused by a G nucleotide insertion in a monotonous repeat of six Gs in HPRT exon 3 , has been reported previously in three other LN patients .", + "entities": [ + "HPRT exon 3" + ] + }, + { + "id": "165", + "type": "gene", + "text": "Each half molecule contains four disulfide linkages and four cis peptides .", + "entities": [] + }, + { + "id": "166", + "type": "gene", + "text": "METHODS : One hundred fourteen consecutive patients ( mean age 61 years ) with focal pancreatic masses , detected on CT , underwent EUS - FNA by using a linear - array echoendoscope and 22 - gauge needles .", + "entities": [] + }, + { + "id": "167", + "type": "gene", + "text": "Consistent with effects on STAT activation , altered SHP - 1 expression also affected EGF - induced activation of the mitogen - activated protein kinase pathway ; expression of SHP - 1 - ( Cys - - > Ser ) inhibited activity of MEK by approximately 25 % , whereas expression of SHP - 1 resulted in a approximately 25 % increase .", + "entities": [ + "STAT", + "SHP - 1", + "EGF", + "mitogen - activated protein kinase", + "SHP - 1 - ( Cys - - > Ser )", + "MEK", + "SHP - 1" + ] + }, + { + "id": "168", + "type": "gene", + "text": "We have cloned a novel 100 - kDa mammalian protein , which was recognized by an anti - peptide antibody against an epitope - containing nuclear localization signal of NF - kappaB p65 subunit .", + "entities": [ + "p65 subunit" + ] + }, + { + "id": "169", + "type": "gene", + "text": "Normal values for the peripheral blood and bone marrow of the grey ( Armenian ) hamster", + "entities": [] + }, + { + "id": "170", + "type": "gene", + "text": "The mean extracted concentration of flucloxacillin obtained at operation was 12 . 9 micrograms / ml ( SD 5 . 25 ) in synovial fluid ; 2 . 9 micrograms / g ( SD 3 . 59 ) in synovium ; 2 . 0 micrograms / g ( SD 1 . 48 ) in cancellous bone and 1 . 3 micrograms / g ( SD 1 . 25 ) in cortical bone .", + "entities": [] + }, + { + "id": "171", + "type": "gene", + "text": "When nifA mRNA 5 ' start points were mapped by primer extension , both a minor upstream transcript ( s ) starting 45 bp distal to the anaerobox and a major downstream transcript starting 10 bp distal to the sigma 54 box were observed .", + "entities": [ + "nifA mRNA", + "sigma 54" + ] + }, + { + "id": "172", + "type": "gene", + "text": "In this study , evidence is presented that temporally and spatially specific mef2 expression is controlled by a complex array of cis - acting regulatory modules that are responsive to different genetic signals .", + "entities": [ + "mef2" + ] + }, + { + "id": "173", + "type": "gene", + "text": "5 ( Sunset Yellow FCF ) were determined using liquid chromatography / mass spectrometry ( LC / MS ) with electrospray ionization .", + "entities": [] + }, + { + "id": "174", + "type": "gene", + "text": "The rCBF and vasomotion were recorded by laser - doppler fluxmetry .", + "entities": [] + }, + { + "id": "175", + "type": "gene", + "text": "Internal amino acid sequence has now been obtained from this protein which shares 50 - 100 % sequence identity with sequences encoded by mammalian G alpha 11 and G alpha q cDNAs .", + "entities": [ + "mammalian G alpha 11", + "G alpha q cDNAs" + ] + }, + { + "id": "176", + "type": "gene", + "text": "She improved with a combination of benzodiazepines and the acetylcholinesterase inhibitor physostigmine .", + "entities": [ + "acetylcholinesterase" + ] + }, + { + "id": "177", + "type": "gene", + "text": "Molecular identification of smg - 4 , required for mRNA surveillance in C . elegans .", + "entities": [ + "smg - 4" + ] + }, + { + "id": "178", + "type": "gene", + "text": "PAS1 , a yeast gene required for peroxisome biogenesis , encodes a member of a novel family of putative ATPases .", + "entities": [ + "PAS1", + "ATPases" + ] + }, + { + "id": "179", + "type": "gene", + "text": "The 1 , 2 , 3 and 4 year survival rates were 94 % , 84 % , 76 % and 63 % , respectively .", + "entities": [] + }, + { + "id": "180", + "type": "gene", + "text": "Up to 95 % of the total UV exposure received is in the UV - A waveband ( 320 - 400 nm ) .", + "entities": [] + }, + { + "id": "181", + "type": "gene", + "text": "Thirty minutes of supine restraint decreased DOPAC concentrations in the median eminence of female rats that were not exposed to ether , and brief exposure to ether enhanced this effect .", + "entities": [] + }, + { + "id": "182", + "type": "gene", + "text": "This is the first report that an in vitro - synthesized alphavirus RNA lacking a poly ( A ) tail can initiate infection and produce 3 ' polyadenylated viral genome in vivo .", + "entities": [] + }, + { + "id": "183", + "type": "gene", + "text": "17 . 5 % of cycles ) .", + "entities": [] + }, + { + "id": "184", + "type": "gene", + "text": "On cessation of steroid therapy the patient was noted to have radiologic manifestations of hypertrophic osteoarthropathy ( HOA ) as well as clinical and laboratory features of rheumatoid arthritis ( RA ) .", + "entities": [] + }, + { + "id": "185", + "type": "gene", + "text": "Paradoxically , coexpression of the transcriptionally inactive , amino - terminally deleted IDX - 1 mutant proteins , either with the wild - type IDX - 1 or with themselves , results in a marked enhancement of transactivation of the transcriptional TAAT - 1 element reporter .", + "entities": [ + "IDX - 1 mutant proteins", + "wild - type IDX - 1", + "TAAT - 1 element reporter" + ] + }, + { + "id": "186", + "type": "gene", + "text": "Hematopoietic growth factors have already had an enormous impact on transfusion practice by eliminating or reducing the need for red blood cell transfusions in a variety of anemic states characterized by an absolute or relative decrease in erythropoietin .", + "entities": [ + "Hematopoietic growth factors", + "erythropoietin" + ] + }, + { + "id": "187", + "type": "gene", + "text": "This night - day oscillation is driven by the endogenous clock ( located in the suprachiasmatic nucleus , SCN ) .", + "entities": [] + }, + { + "id": "188", + "type": "gene", + "text": "Src homology ( SH ) domain dependent protein - protein interactions are important to tyrosine kinase receptor signal transduction .", + "entities": [ + "Src homology", + "SH", + "tyrosine kinase receptor" + ] + }, + { + "id": "189", + "type": "gene", + "text": "CONCLUSION : The authors emphasize that the initial management of primary STS should be adequate and suggest that safty margin of > or = 2 cm should be adhered to .", + "entities": [] + }, + { + "id": "190", + "type": "gene", + "text": "The DNA sequence encodes a protein of 1520 amino acids with sequence homology to the human c - abl proto - oncogene product , beginning at the amino terminus and extending 656 amino acids through the region essential for tyrosine kinase activity .", + "entities": [ + "human c - abl proto - oncogene product", + "tyrosine kinase" + ] + }, + { + "id": "191", + "type": "gene", + "text": "CRS function in a 5 ' LTR - linked gene expression assay correlates with the ability of both p60CRS and p40CRS to interact with 5 ' LTR RNA in vitro .", + "entities": [ + "CRS", + "p60CRS", + "p40CRS" + ] + }, + { + "id": "192", + "type": "gene", + "text": "In mitogen - stimulated splenocytes , Gfi - 1 expression begins to rise at 12 h after stimulation and reaches very high levels after 50 h , suggesting that it may be functionally involved in events occurring after the interaction of IL - 2 with its receptor , perhaps during the transition from the G1 to the S phase of the cell cycle .", + "entities": [ + "Gfi - 1", + "IL - 2" + ] + }, + { + "id": "193", + "type": "gene", + "text": "The authors did not detect any significant correlations between parameters of the lipids of bone marrow and leptin levels in serum and bone marrow .", + "entities": [ + "leptin" + ] + }, + { + "id": "194", + "type": "gene", + "text": "In vivo , MyoD requires this tryptophan motif to evoke chromatin remodeling in the Myogenin promoter and to activate Myogenin transcription .", + "entities": [ + "MyoD", + "Myogenin promoter", + "Myogenin" + ] + }, + { + "id": "195", + "type": "gene", + "text": "In accordance with clinical improvement we found a decrease of laboratory indicators of inflammation ( C - reactive protein , alpha 2 - globuline , prostaglandin E2 ) .", + "entities": [ + "C - reactive protein", + "alpha 2 - globuline" + ] + }, + { + "id": "196", + "type": "gene", + "text": "Each type was divided into two subgroups on the basis of whether the body and tail of the pancreas showed intense fatty replacement ( type a = negative for intense fatty replacement , type b = positive for intense fatty replacement ) .", + "entities": [] + }, + { + "id": "197", + "type": "gene", + "text": "This mechanism is in contrast to other cases of splicing regulation by PTB , in which the protein represses the splice site to which it binds .", + "entities": [ + "PTB" + ] + }, + { + "id": "198", + "type": "gene", + "text": "This growth arrest is partly suppressed on minimal medium or under conditions in which the cells are less dependent on mitochondrial metabolism .", + "entities": [] + }, + { + "id": "199", + "type": "gene", + "text": "Human acid ceramidase ( ( AC ) N - acylsphingosine amidohydrolase , EC 3 . 5 .", + "entities": [ + "Human acid ceramidase", + "( AC ) N - acylsphingosine amidohydrolase", + "EC 3 . 5" + ] + }, + { + "id": "200", + "type": "gene", + "text": "Respiratory parameters suggested that M6G produced less respiratory depression than morphine .", + "entities": [] + }, + { + "id": "201", + "type": "gene", + "text": "The healing rate in HIV - positive patients was 66 percent after 14 weeks and 100 percent after 32 weeks ; the corresponding figures for patients with acquired immunodeficiency syndrome were 0 and 50 percent .", + "entities": [] + }, + { + "id": "202", + "type": "gene", + "text": "This study proposes an estimator for such global synchronizing effects upon unit - pair correlations based on local field potentials ( LFPs ) .", + "entities": [] + }, + { + "id": "203", + "type": "gene", + "text": "The aim of the study was to correlate the responsiveness to bronchoprovocation with methacholine in subjects a with allergic rhinitis during and out of the pollen season with total serum IgE and blood eosinophils .", + "entities": [ + "IgE" + ] + }, + { + "id": "204", + "type": "gene", + "text": "A comparison of physical and cytogenetic estimates of radiation dose in patients treated with iodine - 131 for thyroid carcinoma .", + "entities": [] + }, + { + "id": "205", + "type": "gene", + "text": "It is concluded that in patients with first - attack genital herpes , the type of HSV is the most important determinant of subsequent recurrences and that intravenous acyclovir has little effect on subsequent recurrences .", + "entities": [] + }, + { + "id": "206", + "type": "gene", + "text": "Overall , lesions infiltrating the deep lamina propria do not exhibit a reduced frequency of occurrence compared to lesions infiltrating the skeletal muscle ; however , carcinomas affecting other oral sites showed a reduced frequency of deeply infiltrating lesions in comparison to more superficial lesions .", + "entities": [] + }, + { + "id": "207", + "type": "gene", + "text": "Determined as migration differentials , chemotactic and chemokinetic responsiveness tended to be higher in the neutropenic group .", + "entities": [] + }, + { + "id": "208", + "type": "gene", + "text": "It was found that under the selected conditions a linear dependence exists between the betaI % value and lgC within the range of 0 . 5 - - 10 mug ruscogenin .", + "entities": [] + }, + { + "id": "209", + "type": "gene", + "text": "CAL gain amounted to 4 . 2 + / - 1 . 3 mm , 60 % of the defects showing CAL gain > or = 4 mm .", + "entities": [] + }, + { + "id": "210", + "type": "gene", + "text": "By using total - protein extracts from mycelia grown under penicillin producing conditions we have detected a DNA - binding activity that specifically shifts a promoter fragment located between - 654 and - 455 ( relative to IPNS tsp ) .", + "entities": [ + "IPNS tsp" + ] + }, + { + "id": "211", + "type": "gene", + "text": "Plasma and bladder platinum concentration were measured following intravesical DDP , and also histopathological examination , urinalysis , complete blood count and blood chemistry were performed in order to know the toxicity of intravesical DDP .", + "entities": [] + }, + { + "id": "212", + "type": "gene", + "text": "SUP46 is implicated in translation fidelity and encodes the ribosomal protein S13 .", + "entities": [ + "SUP46", + "ribosomal protein S13" + ] + }, + { + "id": "213", + "type": "gene", + "text": "DMI and 2 - OH - DMI concentrations were determined in a similar group of 61 DMI - treated patients .", + "entities": [] + }, + { + "id": "214", + "type": "gene", + "text": "Because endogenous HSF DNA - binding activity is low and anti - hHSF1 antibody does not recognize Xenopus HSF , we employed this system for mapping regions in hHSF1 that are required for the maintenance of the monomeric state .", + "entities": [ + "HSF", + "anti - hHSF1 antibody", + "Xenopus HSF", + "hHSF1" + ] + }, + { + "id": "215", + "type": "gene", + "text": "Pneumothorax following lung abscess in the renal transplant patient .", + "entities": [] + }, + { + "id": "216", + "type": "gene", + "text": "Protein phosphorylation appears to play a critical role in uPA gene expression in these cells ; protein kinase C - activating phorbol esters cooperate with pp60v - src to synergistically increase uPA mRNA , whereas cyclic AMP ( cAMP ) - dependent protein kinase - activating agents ( e . g . , 8 - bromo cAMP ) repress uPA mRNA levels .", + "entities": [ + "uPA gene", + "protein kinase C", + "pp60v - src", + "uPA mRNA", + "cyclic AMP ( cAMP ) - dependent protein kinase", + "uPA mRNA" + ] + }, + { + "id": "217", + "type": "gene", + "text": "The third ORF generates a transcript of 1 . 6 kb and encodes a protein of 382 residues including a perfect match to the consensus sequence of a C2H2 zinc finger domain ; it shares a strong homology with yeast Mig1p and Cre - A from Aspergillus , Emericella and E . coli .", + "entities": [ + "yeast Mig1p", + "Cre - A from Aspergillus , Emericella and E . coli" + ] + }, + { + "id": "218", + "type": "gene", + "text": "The effect of the thromboxane A2 ( TXA2 ) / prostaglandin endoperoxide receptor antagonist , SQ 29 , 548 on pacing - induced ischemia was determined in anesthetized open - chest dogs .", + "entities": [ + "thromboxane A2 ( TXA2 ) / prostaglandin endoperoxide receptor" + ] + }, + { + "id": "219", + "type": "gene", + "text": "When the LCx was partially occluded , mild PM - induced tachycardia resulted in decreased AoP ( P = 0 . 045 ) as well as in decreased SV ( P = 0 . 048 ) ; the LVEDP remained high ( P = 0 . 002 ) .", + "entities": [] + }, + { + "id": "220", + "type": "gene", + "text": "Furthermore , the wide distribution of the GFP - POLO protein to all compartments of the mitotic apparatus provides a valuable tool for future studies on cell cycle during development .", + "entities": [ + "GFP", + "POLO" + ] + }, + { + "id": "221", + "type": "gene", + "text": "( Cactaceae ) waste matter .", + "entities": [] + }, + { + "id": "222", + "type": "gene", + "text": "Gene silencing associated with repeated DNA sequences has been reported for many eukaryotes , including plants .", + "entities": [] + }, + { + "id": "223", + "type": "gene", + "text": "It also contains a picornaviral 3C - like protease domain and two papain - like protease domains .", + "entities": [ + "picornaviral 3C - like protease domain", + "papain - like protease domains" + ] + }, + { + "id": "224", + "type": "gene", + "text": "Vacuolar membrane vesicles from hum1 mutants lack all Ca2 + / H + antiport activity , demonstrating that Hum1p catalyzes the exchange of Ca2 + for H + across the yeast vacuolar membrane .", + "entities": [ + "hum1 mutants", + "Hum1p" + ] + }, + { + "id": "225", + "type": "gene", + "text": "Prevalence of sleep - disordered breathing ( SDB ) is reported to increase in menopausal women .", + "entities": [] + }, + { + "id": "226", + "type": "gene", + "text": "Droperidol - induced extrapyramidal symptoms in an adolescent following strabismus surgery .", + "entities": [] + }, + { + "id": "227", + "type": "gene", + "text": "Improvement of the polypyrimidine tract also increased the splicing efficiency , but to a degree slightly less than that obtained with the branchpoint mutation .", + "entities": [] + }, + { + "id": "228", + "type": "gene", + "text": "These data provide strong evidence that E2F or an E2F - related transcription factor is involved in the regulation of nonmuscle myosin expression .", + "entities": [ + "E2F", + "E2F - related transcription factor", + "nonmuscle myosin" + ] + }, + { + "id": "229", + "type": "gene", + "text": "During coronary stenosis , on the contrary , intracoronary procaterol at the same dose significantly deteriorated regional myocardial dysfunction without changing LCX flow , global hemodynamics and cardiac lactate metabolism .", + "entities": [] + }, + { + "id": "230", + "type": "gene", + "text": "( total soluble solids ) and organoleptic characteristics under the influence of different treatments .", + "entities": [] + }, + { + "id": "231", + "type": "gene", + "text": "The iron dependence of transcription and expression of cvaA , which encodes a transporter accessory protein , and cvi , encoding the colicin V immunity protein , was assessed under conditions of iron excess or depletion .", + "entities": [ + "cvaA", + "cvi", + "colicin V immunity protein" + ] + }, + { + "id": "232", + "type": "gene", + "text": "Obstruction of the ERF repressor function by the transactivating members of the ets family of genes ( i . e . gag - myb - ets ) may be essential for the control of genes involved in cell proliferation and may also underlie their tumorigenic effects .", + "entities": [ + "ERF repressor", + "ets family", + "gag", + "myb", + "ets" + ] + }, + { + "id": "233", + "type": "gene", + "text": "Neither Ha - Ras ( G12V , T35S ) ( Ha - RasV12S35 ) , which activates the Rafl signaling pathway , nor Ha - Ras ( G12V , E37G ) ( Ha - RasV12G37 ) , which stimulates the RalGDS pathway , did not have significant effects on factor - withdrawal apoptosis of myeloid cells .", + "entities": [ + "Ha - Ras", + "Ha - RasV12S35", + "Rafl", + "Ha - Ras ( G12V , E37G )", + "Ha - RasV12G37", + "RalGDS" + ] + }, + { + "id": "234", + "type": "gene", + "text": "Diver respiratory responses to a tunable closed - circuit breathing apparatus .", + "entities": [] + }, + { + "id": "235", + "type": "gene", + "text": "The CPK - MB isoenzyme showed no percentage increase of total CPK higher than 5 % , measured at 6 , 12 , and 24 h after the shock , independent of the number of attempts of cardioversion .", + "entities": [ + "CPK - MB", + "CPK" + ] + }, + { + "id": "236", + "type": "gene", + "text": "Dipetalonema ( Alafilaria ) hydrochoerus subgen .", + "entities": [] + }, + { + "id": "237", + "type": "gene", + "text": "et sp .", + "entities": [] + }, + { + "id": "238", + "type": "gene", + "text": "n .", + "entities": [] + }, + { + "id": "239", + "type": "gene", + "text": "The PRB - 1b gene encodes for a basic - type component of the pathogenesis - related PR - 1 protein family .", + "entities": [ + "PRB - 1b gene", + "PR - 1 protein family" + ] + }, + { + "id": "240", + "type": "gene", + "text": "These changes were the result of a decrease in afterload : mean aortic pressure fell from 85 + / - 11 . 8 to 68 + / - 19 . 6 mmHg ( p less than 0 . 01 ) and systemic arterial resistance fell from 2 886 + / - 745 to 2 010 + / - 610 dynes / cm - 5 / sec / m - 2 ( p less than 0 . 01 ) .", + "entities": [] + }, + { + "id": "241", + "type": "gene", + "text": "Pharmacological and pharmacokinetic characteristics of the non - ionic monomeric X - ray contrast agent iopromide ( Ultravist , CAS 73334 - 07 - 3 ) were evaluated in preclinical studies .", + "entities": [] + }, + { + "id": "242", + "type": "gene", + "text": "This domain without the canonical anticodon loop or the tyrosine anticodon acts as an anchor for TyrRS interaction leading to a better efficiency of tyrosylation .", + "entities": [ + "TyrRS" + ] + }, + { + "id": "243", + "type": "gene", + "text": "Children who developed lower respiratory tract infections or PCP had increased rates of decline of CD4 cell counts during the first 6 months of life .", + "entities": [ + "CD4" + ] + }, + { + "id": "244", + "type": "gene", + "text": "Acute experiments on nembutal - anesthetized cats ( 50 mg / kg ) were employed to investigate the effect of 1 T pulsating magnetic field ( PMF ) on neuromuscular system of the leg .", + "entities": [] + }, + { + "id": "245", + "type": "gene", + "text": "The GTPase activity of CDC42Ce is moderately stimulated by human n - chimaerin , a GTPase - activating protein for the related p21 rac1 .", + "entities": [ + "GTPase", + "CDC42Ce", + "human n - chimaerin", + "GTPase - activating protein", + "rac1" + ] + }, + { + "id": "246", + "type": "gene", + "text": "These results suggest that both transcription activators depend on or interact with different subunits of RNA polymerase , although their role in formation of proper DNA geometry may also be crucial .", + "entities": [ + "RNA polymerase" + ] + }, + { + "id": "247", + "type": "gene", + "text": "A sequence homology analysis between human nm23 - H1 and the homolog gene of the rat ( NDP - K beta ) shows that exon - intron boundaries are well conserved between these two species .", + "entities": [ + "human nm23 - H1", + "NDP - K beta" + ] + }, + { + "id": "248", + "type": "gene", + "text": "BACKGROUND : Previous studies have indicated that the 60 - , 30 - , 28 - and 12 - item versions of the General Health Questionnaire ( GHQ ) are liable to retest effects , especially when administered multiple times with short intervals .", + "entities": [] + }, + { + "id": "249", + "type": "gene", + "text": "Although it has two potential binding sites , the purified MerR homodimer binds only one Hg ( II ) ion , employing Cys82 from one monomer and Cys117 and Cys126 from the other .", + "entities": [ + "MerR homodimer" + ] + }, + { + "id": "250", + "type": "gene", + "text": "Bacterial metabolism of 4 - chlorophenoxyacetate .", + "entities": [] + }, + { + "id": "251", + "type": "gene", + "text": "However , in the subgroup with normal Ht ( < 0 . 45 l / l ; n = 201 ) there was a significant reduction ( p < 0 . 05 ) of the mortality after 3 months ( 27 % and 16 % , respectively ) and an increase of independence at home ( 35 % and 48 % , respectively ) due to a reduction of the viscosity by means of haemodilution with albumin ( a specific viscosity effect in the normovolaemic group ) .", + "entities": [ + "albumin" + ] + }, + { + "id": "252", + "type": "gene", + "text": "The results suggest that , although both the N - and C - terminal regions of talin bind actin , the properties of these two regions of the protein are distinct .", + "entities": [ + "talin", + "actin" + ] + }, + { + "id": "253", + "type": "gene", + "text": "In addition , the - 119 to - 81 fragment of the CCK promoter contains a transcriptional enhancer that potentiates the transcription from the herpes simplex virus thymidine kinase promoter in a position - and orientation - independent manner .", + "entities": [ + "CCK promoter", + "thymidine kinase promoter" + ] + }, + { + "id": "254", + "type": "gene", + "text": "The carcinogen bioassay therefore is a very important component of the battery of toxicological tests used in hazard evaluation .", + "entities": [] + }, + { + "id": "255", + "type": "gene", + "text": "Accordingly , we designated this gene CTL1 ( capping enzyme RNAtriphosphatase - like 1 ) .", + "entities": [ + "gene CTL1", + "capping enzyme RNAtriphosphatase - like 1" + ] + }, + { + "id": "256", + "type": "gene", + "text": "The results indicate that the open - section effect decreases the torsional stiffness and stress concentration effects decrease the torsional strength of a long bone with a longitudinal defect .", + "entities": [] + }, + { + "id": "257", + "type": "gene", + "text": "Recent advances have shown that volatile sulfur is a result of ecological interactions and transformation processes through planktonic food webs .", + "entities": [] + }, + { + "id": "258", + "type": "gene", + "text": "Serum Fibrin Degradation Products ( FDP ) were determined in 50 oral cancer patients and 50 normal individuals prior to any kind of treatment .", + "entities": [ + "Fibrin Degradation Products", + "FDP" + ] + }, + { + "id": "259", + "type": "gene", + "text": "It has been demonstrated previously that Pax - 6 , a paired domain ( PD ) / homeodomain ( HD ) transcription factor critical for eye development , contributes to the activation of the alphaB - , alphaA - , delta1 - , and zeta - crystallin genes in the lens .", + "entities": [ + "Pax - 6", + "paired domain", + "PD", + "homeodomain", + "HD", + "alphaB - , alphaA - , delta1 - , and zeta - crystallin" + ] + }, + { + "id": "260", + "type": "gene", + "text": "Therefore , the impaired floor plate development in oep mutants is not caused by the absence of the floor plate inducer shh .", + "entities": [ + "oep mutants", + "floor plate inducer shh" + ] + }, + { + "id": "261", + "type": "gene", + "text": "San Martin ' s psychological traits coupled to his work with masonic lodges that allowed him to display his abilities as strategist and political ruler .", + "entities": [] + }, + { + "id": "262", + "type": "gene", + "text": "Our laboratory has recently identified two phosducin - like orphan proteins ( PhLOP1 and PhLOP2 ) that lack the ability to interact with Gbetagamma .", + "entities": [ + "phosducin - like orphan proteins", + "PhLOP1", + "PhLOP2", + "Gbetagamma" + ] + }, + { + "id": "263", + "type": "gene", + "text": "Fatal encephalitis in a patient with chronic graft - versus - host disease .", + "entities": [] + }, + { + "id": "264", + "type": "gene", + "text": "Of the serum neutralizing ( SN ) antibody negative calves 89 . 7 % ( 26 / 29 ) and 92 . 8 % ( 90 / 97 ) developed SN antibody 1 month after intranasal and intramuscular vaccination , respectively .", + "entities": [ + "serum neutralizing ( SN ) antibody", + "SN antibody" + ] + }, + { + "id": "265", + "type": "gene", + "text": "Finally , using in vitro binding studies , we showed that SREBP2 was able to displace ADD1 / SREBP1 binding from the sterol regulatory element ( SRE ) site .", + "entities": [ + "SREBP2", + "ADD1", + "SREBP1" + ] + }, + { + "id": "266", + "type": "gene", + "text": "These data suggest that the G - protein gene family may be distributed over at least two human chromosomes .", + "entities": [ + "G - protein gene family" + ] + }, + { + "id": "267", + "type": "gene", + "text": "When cysteine is scanned through the helices , characteristic repeating patterns of solvent exposure and burial are observed .", + "entities": [] + }, + { + "id": "268", + "type": "gene", + "text": "To characterize this effect , we looked for targets of NS1 influenza virus protein among cellular translation factors .", + "entities": [ + "NS1 influenza virus protein" + ] + }, + { + "id": "269", + "type": "gene", + "text": "We present this case because of the rarity of left ventricular involvement associated with ARVD .", + "entities": [] + }, + { + "id": "270", + "type": "gene", + "text": "A two phase slug flow tubular heat exchanger was used for the thermal inactivation of Listeria monocytogenes in natural infected milk from seven cows .", + "entities": [] + }, + { + "id": "271", + "type": "gene", + "text": "The equilibrium phosphorus content ( EPC0 ) of surface soil was generally higher than the SRP content of drainage water , at one farm by 1 order of magnitude .", + "entities": [] + }, + { + "id": "272", + "type": "gene", + "text": "The central visual fields of 2165 normal and 106 glaucoma eyes were measured using a threshold related suprathreshold strategy .", + "entities": [] + }, + { + "id": "273", + "type": "gene", + "text": "After all doses of d - amphetamine , responding occurred largely on the saline key under both schedules .", + "entities": [] + }, + { + "id": "274", + "type": "gene", + "text": "Evolutionary conservation of homeodomain - binding sites and other sequences upstream and within the major transcription unit of the Drosophila segmentation gene engrailed .", + "entities": [ + "homeodomain", + "Drosophila segmentation gene engrailed" + ] + }, + { + "id": "275", + "type": "gene", + "text": "A polypeptide chain of 34 residues of the deduced yeast amino acid sequence closely resembles a peptide sequence at the ADP binding site of bovine muscle pyruvate kinase .", + "entities": [ + "bovine muscle pyruvate kinase" + ] + }, + { + "id": "276", + "type": "gene", + "text": "In this study , rabbits were used to evaluate the sutured wound reaction with Dexon or nylon in the conjunctival flap 1 , 4 , 7 , 14 and 28 days after trabeculectomy surgery with or without the use of mitomycin - C .", + "entities": [] + }, + { + "id": "277", + "type": "gene", + "text": "CONCLUSIONS : Physiologic pacing provides little benefit over ventricular pacing for the prevention of stroke or death due to cardiovascular causes .", + "entities": [] + }, + { + "id": "278", + "type": "gene", + "text": "MCh infusion caused a concentration - dependent increase in airway resistance at constant QBA .", + "entities": [] + }, + { + "id": "279", + "type": "gene", + "text": "\" In vitro \" study of dentin adhesion to adhesives made from urethane molecules with free groups of isocyanate", + "entities": [] + }, + { + "id": "280", + "type": "gene", + "text": "An examination of the properties of sequences surrounding ARS1 left open the possibility that ABFI enhances the initiation of DNA replication at ARS1 by transcriptional activation .", + "entities": [ + "ABFI" + ] + }, + { + "id": "281", + "type": "gene", + "text": "The GafChromic method has proven to be an accurate and rapid method of analysis and could be easily incorporated into a quality assurance program .", + "entities": [] + }, + { + "id": "282", + "type": "gene", + "text": "In contrast , the contractile action of arachidonic acid , via a presumed cyclooxygenase product that mediated the contractions caused by both TF and EGF , was not blocked by any of the signal pathway probe inhibitors .", + "entities": [ + "cyclooxygenase", + "TF", + "EGF" + ] + }, + { + "id": "283", + "type": "gene", + "text": "The efficacy and safety of a novel percutaneous anaesthetic preparation based on amethocaine has been investigated in the paediatric clinical environment .", + "entities": [] + }, + { + "id": "284", + "type": "gene", + "text": "The neuroprotective efficacy of the selective N - type voltage - sensitive calcium channel blocker , SNX - 111 , was evaluated in spontaneously hypertensive rats subjected to 60 min of focal cerebral ischemia by permanent ligation of the right common carotid artery and temporary occlusion of the right middle cerebral artery .", + "entities": [] + }, + { + "id": "285", + "type": "gene", + "text": "Following 20 min of steady state anaesthesia during which measurements of IOP , arterial pressure , heart rate , FIO2 , FE ' CO2 and CVP were recorded , one group of patients received atracurium 0 . 45 mg kg - 1 and the other pancuronium 0 . 1 mg kg - 1 .", + "entities": [] + }, + { + "id": "286", + "type": "gene", + "text": "1 ) CFDN , AMPC and MNZ showed a potent antimicrobial activity against H . pylori , and especially , AMPC showed a marked bactericidal activity in a short time .", + "entities": [] + }, + { + "id": "287", + "type": "gene", + "text": "Cell factor - mediated regulatory interactions are involved in regulating the restricted expression of the HCMV major immediate - early ( IE ) gene ( J .", + "entities": [ + "HCMV major immediate - early ( IE ) gene" + ] + }, + { + "id": "288", + "type": "gene", + "text": "The ratio of radioactivity in tumour compared with normal tissue ( T : N ratio ) was determined after simultaneously injecting microspheres into the portal and arterial circulation of each animal .", + "entities": [] + }, + { + "id": "289", + "type": "gene", + "text": "67 393 bp of contiguous DNA located between markers cdc18 and cdc14 on the right arm of fission yeast chromosome II has been sequenced as part of the European Union Schizosaccharomyces pombe genome sequencing project .", + "entities": [ + "cdc18", + "cdc14" + ] + }, + { + "id": "290", + "type": "gene", + "text": "Deletion of the apeA gene , either with or without deletion of other proteinases ( protease IV and aminopeptidase N ) , did not have any effect on cell growth in the various media tested .", + "entities": [ + "apeA gene", + "protease IV", + "aminopeptidase N" + ] + }, + { + "id": "291", + "type": "gene", + "text": "A new technique to create an artificial stenosis in the native LAD using a hemoclip .", + "entities": [] + }, + { + "id": "292", + "type": "gene", + "text": "Our evidence derives from three principal observations : 1 ) a transfection construct containing only 122 nucleotides ( nt ) of promoter 1 and 328 nt of the 5 ' - UTR retained full PGE2 - stimulated reporter expression ; 2 ) maximal PGE2 - driven reporter expression required the presence of nt 196 to 328 of exon 1 when tested within the context of IGF - I promoter 1 ; 3 ) cotransfection of IGF - I promoter - luciferase - reporter constructs with a plasmid encoding the alpha - isoform of the catalytic subunit of murine cAMP - dependent protein kinase ( PKA ) produced results comparable to those seen with PGE2 treatment , whereas cotransfection with a plasmid encoding a mutant regulatory subunit of PKA that cannot bind cAMP blocked PGE2 - induced reporter expression .", + "entities": [ + "IGF - I promoter 1", + "IGF - I promoter", + "luciferase", + "murine cAMP - dependent protein kinase", + "PKA", + "PKA" + ] + }, + { + "id": "293", + "type": "gene", + "text": "The motor unit viewed from above .", + "entities": [] + }, + { + "id": "294", + "type": "gene", + "text": "We describe here a Drosophila melanogaster FAK homologue , DFak56 , which maps to band 56D on the right arm of the second chromosome .", + "entities": [ + "Drosophila melanogaster FAK homologue", + "DFak56" + ] + }, + { + "id": "295", + "type": "gene", + "text": "The Dox - A2 ORF driven by the TDH3 promoter complemented the phenotype of a strain deleted for sun2 .", + "entities": [ + "Dox - A2 ORF", + "TDH3 promoter", + "sun2" + ] + }, + { + "id": "296", + "type": "gene", + "text": "Cloning and expression of two genes encoding auxin - binding proteins from tobacco .", + "entities": [ + "auxin - binding proteins" + ] + }, + { + "id": "297", + "type": "gene", + "text": "However , when a second , upstream IRE - like sequence was evaluated by EMSA , a DNA binding pattern distinct from that seen following exposure to IFN - gamma alone was observed after prolonged stimulation with both IFN - alpha and IFN - gamma .", + "entities": [ + "upstream IRE - like sequence", + "IFN - gamma", + "IFN - alpha", + "IFN - gamma" + ] + }, + { + "id": "298", + "type": "gene", + "text": "Angiographic work - up in a patient with late vaginal metastasis from a renal carcinoma .", + "entities": [] + }, + { + "id": "299", + "type": "gene", + "text": "The aim of this retrospective study was to demonstrate that in certain cases of expulsive choroidal hemorrhage ( ECH ) anatomical success and useful vision can be obtained with repeated vitreoretinal surgery .", + "entities": [] + }, + { + "id": "300", + "type": "gene", + "text": "METHODS : We studied 20 symptomatic patients with HOCM ( 12 men ) , mean age 52 + / - 17 years , before and after septal reduction using echocardiography and electrocardiogram ( ECG ) .", + "entities": [] + }, + { + "id": "301", + "type": "gene", + "text": "Nodal domains are regions where a function has definite sign .", + "entities": [] + }, + { + "id": "302", + "type": "gene", + "text": "Serum E2 concentrations increased numerically two - to threefold from d 56 to 140 in controls fed MGA , compared with controls not fed MGA .", + "entities": [] + }, + { + "id": "303", + "type": "gene", + "text": "The ADP - ribosylation factor ( ARF ) family is one of four subfamilies of the RAS superfamily of low molecular weight GTP - binding proteins ( G proteins ) .", + "entities": [ + "ADP - ribosylation factor", + "ARF", + "RAS superfamily", + "low molecular weight GTP - binding proteins", + "G proteins" + ] + }, + { + "id": "304", + "type": "gene", + "text": "INTERPRETATION : It is probable that the cognitive dissonance created by more health information on smoking after 1964 , i . e . the necessary motivation to quit , was reduced as a result of strategic changes in the amount and content of advertising .", + "entities": [] + }, + { + "id": "305", + "type": "gene", + "text": "Once ICP reaches critical values ( > 30 mm Hg ) herniation occurs , usually within 2 to 5 days .", + "entities": [] + }, + { + "id": "306", + "type": "gene", + "text": "Characterization of the 3 ' ends of the plus - strand DNA fragments reveals ( 1 ) that the upstream fragment is elongated beyond PPT2 creating a plus - strand overlap and ( 2 ) that the majority of plus - strand strong - stop DNA fragments bear a copy of the minus - strand primer binding site in agreement with the accepted model of retroviral genomic RNA reverse transcription .", + "entities": [ + "PPT2" + ] + }, + { + "id": "307", + "type": "gene", + "text": "Abundant infiltration of lymphocytes and plasma cells was also wide - spread beneath the carcinoma in situ , together with the lymphoid follicles .", + "entities": [] + }, + { + "id": "308", + "type": "gene", + "text": "Here we demonstrate that THOV NP contains a motif ( KRxxxxxxxxxKTKK ) at amino acid positions 179 - 193 that represents a classical bipartite nuclear localization signal ( NLS ) .", + "entities": [ + "THOV NP" + ] + }, + { + "id": "309", + "type": "gene", + "text": "The authors made an analysis of social - economical conditions limiting the possibilities of rendering cardiosurgical care to children .", + "entities": [] + }, + { + "id": "310", + "type": "gene", + "text": "One hundred units / kg of recombinant human erythropoietin ( rhEPO ) was given subcutaneously 3 times a week for 3 weeks .", + "entities": [ + "recombinant human erythropoietin", + "rhEPO" + ] + }, + { + "id": "311", + "type": "gene", + "text": "Using the rap1t alleles to generate wild - type cells differing only in telomere tract lengths , we also show that telomere position effects are highly sensitive to changes in the size ( or structure ) of the telomeric tract .", + "entities": [ + "rap1t alleles" + ] + }, + { + "id": "312", + "type": "gene", + "text": "CONCLUSIONS : Ketamine - induced dissociative anesthesia produces persistently elevated BIS index which is different from thiamylal and those reported with other conventional anesthetic agents .", + "entities": [] + }, + { + "id": "313", + "type": "gene", + "text": "Pharmacokinetics of Carbamazepine in man : a review .", + "entities": [] + }, + { + "id": "314", + "type": "gene", + "text": "Supershift EMSAs identified that upstream stimulatory factor - 1 and - 2 ( USF - 1 and - 2 ) were part of these complexes .", + "entities": [ + "upstream stimulatory factor - 1 and - 2", + "USF - 1 and - 2" + ] + }, + { + "id": "315", + "type": "gene", + "text": "Glucagon also induced LUC activity very strongly when the CRE1 and CRE2 sites were combined ; induction of the ( CRE1 ) 3 ( CRE2 ) 2SV40 - LUC constructs was positively modulated by the pO2 .", + "entities": [ + "Glucagon", + "LUC", + "LUC" + ] + }, + { + "id": "316", + "type": "gene", + "text": "Ectopic expression of d - axin inhibited Wingless signaling .", + "entities": [ + "d - axin", + "Wingless" + ] + }, + { + "id": "317", + "type": "gene", + "text": "In contrast , the failure of the QKTT motif and TGN46 cytoplasmic tail to induce steady - state ER localization of vesicular stomatitis virus glycoprotein ( VSVG ) chimeras in HeLa and NRK cells indicates that significant differences in early secretory trafficking also exist .", + "entities": [ + "vesicular stomatitis virus glycoprotein", + "VSVG" + ] + }, + { + "id": "318", + "type": "gene", + "text": "Here the cloning and molecular analysis of the Zm - ERabp1 , Zm - ERabp4 , and Zm - ERabp5 genes is presented .", + "entities": [ + "Zm - ERabp1", + "Zm - ERabp4", + "Zm - ERabp5 genes" + ] + }, + { + "id": "319", + "type": "gene", + "text": "The glucose areas following the ingestion of the foods were : Study 1 : glucose 11 . 7 , orange juice 7 . 3 , sucrose 5 . 2 , glucose + fructose 6 . 3 , and fructose 0 . 7 mmol X h / l ; Study 2 : glucose 14 . 6 , orange juice 7 . 3 , apples 5 . 5 , and apple juice 4 . 7 mmol X h / l ; Study 3 : glucose 12 . 6 , ice cream 8 . 1 , milk 3 . 7 , and lactose 4 . 1 mmol X h / l .", + "entities": [] + }, + { + "id": "320", + "type": "gene", + "text": "Stromelysin - 1 , matrix metalloproteinase - 3 ( MMP - 3 ) , is an important endopeptidase selectively expressed by somatic cells in organ tissues .", + "entities": [ + "Stromelysin - 1", + "matrix metalloproteinase - 3", + "MMP - 3" + ] + }, + { + "id": "321", + "type": "gene", + "text": "CONCLUSION : Intravenous diazepam administration before EGD produces a significant fall in SpO2 during the procedure , and so should be avoided ; continuous monitoring of SpO2 should be done during EGD .", + "entities": [] + }, + { + "id": "322", + "type": "gene", + "text": "The time course of RNA1 replication and RNA3 synthesis in induced yeast paralleled that in yeast transfected with natural FHV virion RNA .", + "entities": [ + "RNA1", + "RNA3" + ] + }, + { + "id": "323", + "type": "gene", + "text": "The pia mater at the site of the entry of blood vessels into the central nervous system .", + "entities": [] + }, + { + "id": "324", + "type": "gene", + "text": "A single MEF - 2 site is a major positive regulatory element required for transcription of the muscle - specific subunit of the human phosphoglycerate mutase gene in skeletal and cardiac muscle cells .", + "entities": [ + "MEF - 2 site", + "human phosphoglycerate mutase gene" + ] + }, + { + "id": "325", + "type": "gene", + "text": "Comparison of genomic sequence shows that the ph locus has been duplicated , and that it contains proximal and distal transcription units .", + "entities": [ + "ph locus" + ] + }, + { + "id": "326", + "type": "gene", + "text": "Architecture and anatomy of the genomic locus encoding the human leukemia - associated transcription factor RUNX1 / AML1 .", + "entities": [ + "RUNX1", + "AML1" + ] + }, + { + "id": "327", + "type": "gene", + "text": "We have examined reporter gene ( beta - gal ) expression directed by human heat shock transcription factors 1 and 2 ( HSF1 and HSF2 ) in HeLa cells and in yeast ( Saccharomyces cerevisiae ) .", + "entities": [ + "beta - gal", + "human heat shock transcription factors 1 and 2", + "HSF1", + "HSF2" + ] + }, + { + "id": "328", + "type": "gene", + "text": "The physicians in charge of all patients with evidence of acute Q fever ( seroconversion and / or presence of IgM ) or chronic Q fever ( prolonged disease and / or IgG antibody titer to phase I of Coxiella burnetii > or = 800 ) were asked to complete a questionnaire , which was computerized .", + "entities": [ + "IgM", + "IgG antibody" + ] + }, + { + "id": "329", + "type": "gene", + "text": "In particular , changes in intracellular Ca2 + have the potential to either inhibit or augment the ability of cAMP to stimulate transcription , depending on the presence of specific forms of Ca2 + / calmodulin - dependent protein kinases .", + "entities": [ + "Ca2 + / calmodulin - dependent protein kinases" + ] + }, + { + "id": "330", + "type": "gene", + "text": "This enzyme is designated ( 1 - - > 4 ) - beta - xylan endohydrolase isoenzyme X - I .", + "entities": [ + "( 1 - - > 4 ) - beta - xylan endohydrolase isoenzyme X - I" + ] + }, + { + "id": "331", + "type": "gene", + "text": "These results were superior to those in 24 patients with conventional end - to - end sutures on clinical testing .", + "entities": [] + }, + { + "id": "332", + "type": "gene", + "text": "Tilmicosin is a novel macrolide antibiotic developed for exclusive use in veterinary medicine .", + "entities": [] + }, + { + "id": "333", + "type": "gene", + "text": "Regulation of urokinase plasminogen activator gene transcription in the RAW264 murine macrophage cell line by macrophage colony - stimulating factor ( CSF - 1 ) is dependent upon the level of cell - surface receptor .", + "entities": [ + "urokinase plasminogen activator gene", + "macrophage colony - stimulating factor", + "CSF - 1" + ] + }, + { + "id": "334", + "type": "gene", + "text": "The human immunodeficiency virus type - 1 ( HIV - 1 ) Tat protein regulates transcription by stimulating RNA polymerase processivity .", + "entities": [ + "human immunodeficiency virus type - 1 ( HIV - 1 ) Tat protein", + "RNA polymerase" + ] + }, + { + "id": "335", + "type": "gene", + "text": "UbiA is also unique among known polyubiquitin genes in containing four cis - spliced introns within its coding sequence .", + "entities": [ + "UbiA", + "polyubiquitin genes" + ] + }, + { + "id": "336", + "type": "gene", + "text": "Epithelial nerve fiber defects included absence or distorted architecture of the basal epithelial plexus and intra - epithelial terminals .", + "entities": [] + }, + { + "id": "337", + "type": "gene", + "text": "RACK1 , a receptor for activated C kinase and a homolog of the beta subunit of G proteins , inhibits activity of src tyrosine kinases and growth of NIH 3T3 cells .", + "entities": [ + "RACK1", + "activated C kinase", + "G proteins", + "src tyrosine kinases" + ] + }, + { + "id": "338", + "type": "gene", + "text": "Female subjects , including both normal subjects and idiopathic calcium stone - formers , have higher urinary cyclic AMP levels than their male counterparts , and this difference is significant when urinary cyclic AMP is expressed in the units mumol / g of creatinine .", + "entities": [] + }, + { + "id": "339", + "type": "gene", + "text": "Only the 3 . 0 - kb transcript was detected in adult tissues , where its expression was restricted almost exclusively to the central nervous system .", + "entities": [] + }, + { + "id": "340", + "type": "gene", + "text": "The effects of systemic glucose concentration on brain metabolism following repeated brain ischemia .", + "entities": [] + }, + { + "id": "341", + "type": "gene", + "text": "The target contained between positions - 403 and - 125 acts independently of orientation , in different cell types and species , and in the context of a heterologous promoter .", + "entities": [] + }, + { + "id": "342", + "type": "gene", + "text": "We propose that refeeding may be an important mechanism for activation of certain viral infections previously suppressed by famine .", + "entities": [] + }, + { + "id": "343", + "type": "gene", + "text": "Heat - inducible CAT activity was detectable when additional sequences from the native promoter containing three CCAAT boxes and a single HSE were present in the constructions .", + "entities": [ + "CAT" + ] + }, + { + "id": "344", + "type": "gene", + "text": "This partial transection could permit vasopressin to be secreted in response to a larger rise in plasma sodium concentration .", + "entities": [ + "vasopressin" + ] + }, + { + "id": "345", + "type": "gene", + "text": "Here we have investigated the structural requirements and consequences of regulatory phosphorylation for the interaction between c - Jun and JNK in vivo .", + "entities": [ + "c - Jun", + "JNK" + ] + }, + { + "id": "346", + "type": "gene", + "text": "MZF - 1 represses CAT reporter gene expression via GAL4 binding sites in the nonhematopoietic cell lines NIH 3T3 and 293 .", + "entities": [ + "MZF - 1", + "CAT reporter gene", + "GAL4 binding sites" + ] + }, + { + "id": "347", + "type": "gene", + "text": "Regulation of the human p21 / WAF1 / Cip1 promoter in hepatic cells by functional interactions between Sp1 and Smad family members .", + "entities": [ + "p21", + "WAF1", + "Cip1", + "Sp1", + "Smad family members" + ] + }, + { + "id": "348", + "type": "gene", + "text": "Our results suggest that a sequence match between enhancers and certain promoter elements is critical .", + "entities": [] + }, + { + "id": "349", + "type": "gene", + "text": "The results strongly support the notion that the OBF1 - binding sites and the OBF1 protein are important for normal ARS function as an origin of replication .", + "entities": [ + "OBF1 - binding sites", + "OBF1 protein" + ] + }, + { + "id": "350", + "type": "gene", + "text": "Shape factor correlated well with hemodynamic data for RV / LV systolic pressure ratios ( r = 0 . 93 , p less than 0 . 001 ) for normalized interventricular pressure differences ( r = - 0 . 95 , p less than 0 . 001 ) .", + "entities": [] + }, + { + "id": "351", + "type": "gene", + "text": "The sequence of monkey opsin closely resembles the human sequence at the nucleotide and the amino acid levels , with the latter having only 7 differences out of 348 residues .", + "entities": [ + "monkey opsin" + ] + }, + { + "id": "352", + "type": "gene", + "text": "The method has been satisfactorily applied to the determination of paracetamol in pharmaceutical formulations and biological fluids .", + "entities": [] + }, + { + "id": "353", + "type": "gene", + "text": "Intron - exon structure of the porcine I kappa B alpha - encoding gene .", + "entities": [ + "porcine I kappa B alpha - encoding gene" + ] + }, + { + "id": "354", + "type": "gene", + "text": "We report here the isolation of a full - length cDNA clone coding for a hitherto undiscovered isoform of the bovine C - subunit .", + "entities": [ + "bovine C - subunit" + ] + }, + { + "id": "355", + "type": "gene", + "text": "The clinical efficacy rates evaluated in 151 cases ( KS - R1 group in 77 cases , oral group in 74 cases ) on standard criteria of committee members were 88 . 3 % for the KS - R1 group and 86 . 5 % for the oral group , respectively .", + "entities": [] + }, + { + "id": "356", + "type": "gene", + "text": "The assembly of sequence ready , high - resolution physical maps and construction of minimally overlapping contigs for the human as well as model genomes requires accurate determination of the extent of overlap between adjacent clones as well as their relative orientation .", + "entities": [] + }, + { + "id": "357", + "type": "gene", + "text": "Yeast Gal11 protein mediates the transcriptional activation signal of two different transacting factors , Gal4 and general regulatory factor I / repressor / activator site binding protein 1 / translation upstream factor .", + "entities": [ + "Yeast Gal11 protein", + "Gal4", + "general regulatory factor I", + "repressor / activator site binding protein 1", + "translation upstream factor" + ] + }, + { + "id": "358", + "type": "gene", + "text": "Hemolytic disease of African newborn .", + "entities": [] + }, + { + "id": "359", + "type": "gene", + "text": "The sequence contains an open reading frame of 1744 nt in the virus - sense strand , a 3 ' untranslated region of 1360 nt and a 3 ' poly ( A ) tail .", + "entities": [] + }, + { + "id": "360", + "type": "gene", + "text": "There was no further increase in oxygen consumption when these subjects breathed with inspiratory pressures above SIP .", + "entities": [] + }, + { + "id": "361", + "type": "gene", + "text": "A protein lacking the SH2 and RING finger domains has no activity , but a chimeric protein with the SH2 and RING finger domains of SLI - 1 replaced by the equivalent domains of c - Cbl has activity .", + "entities": [ + "SH2", + "SH2", + "SLI - 1", + "c - Cbl" + ] + }, + { + "id": "362", + "type": "gene", + "text": "Both alleles are functionally expressed and are distributed within CD4 + / CD8 + T cell subsets .", + "entities": [ + "CD4", + "CD8" + ] + }, + { + "id": "363", + "type": "gene", + "text": "Termination of induced VT on the first attempt was comparable with BV pacing ( 87 . 4 % ) versus RV pacing ( 89 . 6 % ) .", + "entities": [] + }, + { + "id": "364", + "type": "gene", + "text": "The NAUSICAA system gives a good knowledge of LET spectra for the first time in space dosimetry .", + "entities": [] + }, + { + "id": "365", + "type": "gene", + "text": "The report highlights the possible contribution of stress factors in the context of therapy resistant periodontal disease , and the results seem to be understandable within the context of a stress system disorder perspective .", + "entities": [] + }, + { + "id": "366", + "type": "gene", + "text": "We linked hypersensitivity site 2 ( HS2 ) from the locus control region ( LCR ) to a A gamma - globin gene ( A gamma * ) mutationally marked to allow its transcript to be distinguished from endogenous gamma - globin mRNA .", + "entities": [ + "A gamma - globin", + "A gamma *", + "gamma - globin" + ] + }, + { + "id": "367", + "type": "gene", + "text": "The Trx - CT fusion protein was produced less efficiently ( 20 % of total soluble cellular protein ) .", + "entities": [ + "Trx", + "CT" + ] + }, + { + "id": "368", + "type": "gene", + "text": "In Saccharomyces cerevisiae the cAMP - dependent kinases ( PKAs ) promote cytoplasmic growth and modulate the growth - regulated mechanism triggering the begin of DNA synthesis .", + "entities": [ + "cAMP - dependent kinases", + "PKAs" + ] + }, + { + "id": "369", + "type": "gene", + "text": "Technetium - 99m methylene diphosphonate scintimammography for evaluation of palpable breast masses .", + "entities": [] + }, + { + "id": "370", + "type": "gene", + "text": "In study 2 , the correlation coefficients between the ISO2 measurements obtained at the ulcer margin and at the adjacent normal mucosa , and delta ISO2 obtained by the experienced observer and one of the three learners were 0 . 94 , 0 . 97 , and 0 . 94 , respectively .", + "entities": [] + }, + { + "id": "371", + "type": "gene", + "text": "The human insulin - like growth factor II ( IGF - II ) gene contains four promoters ( P1 , P2 , P3 and P4 ) .", + "entities": [ + "human insulin - like growth factor II", + "IGF - II" + ] + }, + { + "id": "372", + "type": "gene", + "text": "The 5 ' - flanking region , from nucleotide - 837 to - 336 , contains TATA and inverted CAAT boxes as well as GATA - 1 / SP1 erythroid - specific cis - acting regulatory elements .", + "entities": [ + "GATA - 1", + "SP1" + ] + }, + { + "id": "373", + "type": "gene", + "text": "At the carboxyl terminus , deletion as far as residue 388 did not affect in vitro TRF . C assembly , although trans - activating activity was abolished .", + "entities": [ + "TRF . C" + ] + }, + { + "id": "374", + "type": "gene", + "text": "CONCLUSIONS : Translocation of bacteria or endotoxin from the gastrointestinal tract into the bloodstream has been noted in animal experiments ; however , translocation was not detected in our patients with hemorrhagic shock .", + "entities": [] + }, + { + "id": "375", + "type": "gene", + "text": "Acad .", + "entities": [] + }, + { + "id": "376", + "type": "gene", + "text": "She had been receiving MTX 7 . 5 mg / week for 2 . 5 months because of her vasculitis symptoms .", + "entities": [] + }, + { + "id": "377", + "type": "gene", + "text": "One of these SEBPs , SEBP2 , was shown to be the product of the homeotic gene fork head .", + "entities": [ + "SEBPs", + "SEBP2", + "fork head" + ] + }, + { + "id": "378", + "type": "gene", + "text": "Curing shrinkage and volumetric changes of resin - modified glass ionomer restorative materials .", + "entities": [] + }, + { + "id": "379", + "type": "gene", + "text": "Changes in dopamine receptor sensitivity in humans after heavy alcohol intake .", + "entities": [ + "dopamine receptor" + ] + }, + { + "id": "380", + "type": "gene", + "text": "In a PC12 cell mutant that is deficient in protein kinase A activity ( AB . 11 ) , all three differentiating agents were unable to down - regulate nrg - 1 mRNA .", + "entities": [ + "protein kinase A", + "nrg - 1 mRNA" + ] + }, + { + "id": "381", + "type": "gene", + "text": "Constructs were made in which an AATAAA and the GT - rich region were separated by various distances ranging from 7 to 43 bp .", + "entities": [] + }, + { + "id": "382", + "type": "gene", + "text": "To analyze the mechanism of fos / jun activation by TCDD we have used electrophoretic mobility shift and transient expression assays of reporter gene constructs containing response elements for 12 - O - tetradecanoyl - phorbol - 13 - acetate ( TRE ) , serum ( SRE ) , cAMP ( CRE ) , and aromatic hydrocarbons ( AhRE ) from the fos and jun genes fused to the firefly luciferase gene under the control of the SV40 minimal promoter .", + "entities": [ + "fos", + "jun", + "fos", + "jun genes", + "firefly luciferase gene", + "SV40 minimal promoter" + ] + }, + { + "id": "383", + "type": "gene", + "text": "Comparison of the amino acid sequences of the RPO1 polypeptides of IIV6 , LCDV , and MCV - 1 with the corresponding prokaryotic , eukaryotic , and viral proteins revealed differences in amino acid similarity and phylogenetic relationships .", + "entities": [ + "RPO1 polypeptides of IIV6 , LCDV , and MCV - 1" + ] + }, + { + "id": "384", + "type": "gene", + "text": "However , C4B proteins encoded by monomodular short genes may have relatively higher concentrations than those from long C4A genes .", + "entities": [ + "C4B proteins", + "long C4A genes" + ] + }, + { + "id": "385", + "type": "gene", + "text": "The crystal structure of the VP16 core has been determined at 2 . 1 A resolution .", + "entities": [ + "VP16 core" + ] + }, + { + "id": "386", + "type": "gene", + "text": "Cyclic loading of bone during normal daily activity leads to the formation of microcracks within the tissue matrix of compact bone .", + "entities": [] + }, + { + "id": "387", + "type": "gene", + "text": "Additionally , the mouse promoter contains 22 copies of a CT dinucleotide repeat sequence located approximately 155 bp 5 ' to exon 1 .", + "entities": [] + }, + { + "id": "388", + "type": "gene", + "text": "Sera from euthyroid post - menopausal or pregnant women yielded TSH levels within the normal range .", + "entities": [ + "TSH" + ] + }, + { + "id": "389", + "type": "gene", + "text": "FK506 is 10 - to 100 - fold more potent than cyclosporin A in preventing organ rejection and in toxicity .", + "entities": [] + }, + { + "id": "390", + "type": "gene", + "text": "The histamine H1 receptor antagonists ( antihistamines ) are an important class of medications used for the relief of common symptoms associated with hyperhistaminic conditions occurring in children and adults .", + "entities": [ + "histamine H1 receptor" + ] + }, + { + "id": "391", + "type": "gene", + "text": "One such element , 1P , was employed to clone from a rat pituitary cDNA expression library a novel 417 - amino acid WD protein , designated PREB ( PRL regulatory element binding ) protein .", + "entities": [ + "417 - amino acid WD protein", + "PREB ( PRL regulatory element binding ) protein" + ] + }, + { + "id": "392", + "type": "gene", + "text": "Pyrrolidine dithiocarbamate , a potent transcriptional inhibitor of the viral LTR , abrogated the cytokine responses in both U1 and ACH - 2 cells , suggesting a common TNF - alpha - mediated transcriptional mechanism in these cell types despite their different modes of provirus latency .", + "entities": [ + "viral LTR", + "TNF - alpha" + ] + }, + { + "id": "393", + "type": "gene", + "text": "French bean contains a small family of genes encoding PAL and two of these genes , PAL2 and PAL3 , have been shown to be differentially expressed at the mRNA level in bean tissues .", + "entities": [ + "genes encoding PAL", + "PAL2", + "PAL3" + ] + }, + { + "id": "394", + "type": "gene", + "text": "We report a patient developing factor VII inhibitor possibly as a reaction to penicillin administration ; it gave rise to fatal haemorrhage .", + "entities": [ + "factor VII inhibitor" + ] + }, + { + "id": "395", + "type": "gene", + "text": "A sequence comparison reveals two CCAAT / enhancer binding protein ( C / EBP ) consensus sequences , basic DNA binding region and leucine zippers 1 and 2 ( bZIP1 and bZIP2 ) , within this region .", + "entities": [ + "CCAAT / enhancer binding protein", + "C / EBP" + ] + }, + { + "id": "396", + "type": "gene", + "text": "The product of rat gene 33 was identified as an ErbB - 2 - interacting protein in a two - hybrid screen employing the ErbB - 2 juxtamembrane and kinase domains as bait .", + "entities": [ + "rat gene 33", + "ErbB - 2 - interacting protein", + "ErbB - 2 juxtamembrane and kinase domains" + ] + }, + { + "id": "397", + "type": "gene", + "text": "A canonical TATA box was not detected .", + "entities": [] + }, + { + "id": "398", + "type": "gene", + "text": "The correlation between PaCO2 and PtcO2 in RDS was insufficient to make clinical judgement .", + "entities": [] + }, + { + "id": "399", + "type": "gene", + "text": "We recently found that the p72syk protein tyrosine kinase is physically associated with the TCR / CD3 complex and is rapidly tyrosine phosphorylated and activated by receptor triggering also in T cells lacking p56lck .", + "entities": [ + "p72syk protein tyrosine kinase", + "TCR", + "CD3", + "p56lck" + ] + }, + { + "id": "400", + "type": "gene", + "text": "The behavior of different types of polytetrafluoroethylene ( PTFE ) prostheses in the reparative scarring process of abdominal wall defects .", + "entities": [] + }, + { + "id": "401", + "type": "gene", + "text": "Simple reaction time ( RT ) to a peripheral visual target ( S2 ) is shortened when a non - informative cue ( S1 ) is flashed at the S2 location 100 - 150 ms before target onset ( early facilitation ) .", + "entities": [] + }, + { + "id": "402", + "type": "gene", + "text": "These findings suggest that late MYO / M is more useful than washout rate to assess the effect of treatment on heart failure due to DCM .", + "entities": [] + }, + { + "id": "403", + "type": "gene", + "text": "Risk of HTLV infection in patients on haemodialysis .", + "entities": [] + }, + { + "id": "404", + "type": "gene", + "text": "The bcl - 2 gene can potentially encode 26 - and 22 - kDa proteins that differ only in their carboxyl tails because of an alternative splicing mechanism .", + "entities": [ + "bcl - 2 gene" + ] + }, + { + "id": "405", + "type": "gene", + "text": "( 1992 ) Biochemistry 31 , 3351 - 3358 ] .", + "entities": [] + }, + { + "id": "406", + "type": "gene", + "text": "Anesthesia was maintained with isoflurane ( ISO ) / N2O / O2 inhalation .", + "entities": [] + }, + { + "id": "407", + "type": "gene", + "text": "The nucleosomal response associated with immediate - early gene induction is mediated via alternative MAP kinase cascades : MSK1 as a potential histone H3 / HMG - 14 kinase .", + "entities": [ + "immediate - early gene", + "MAP kinase cascades", + "MSK1", + "histone H3", + "HMG - 14" + ] + }, + { + "id": "408", + "type": "gene", + "text": "A consensus binding site for the transcription factor SP1 was identified in intron As downstream of the proenkephalin germ cell cap site region .", + "entities": [ + "SP1", + "proenkephalin germ cell cap site region" + ] + }, + { + "id": "409", + "type": "gene", + "text": "Interestingly , a decreased transcription from the endogenous c - Myb promoter was observed in several HTLV - I transformed T - cell lines .", + "entities": [ + "c - Myb promoter" + ] + }, + { + "id": "410", + "type": "gene", + "text": "Sample treatment was optimized in order to achieve a complete extraction of labetalol diastereoisomers and to avoid racemization during extraction .", + "entities": [] + }, + { + "id": "411", + "type": "gene", + "text": "It has been calculated that 600 , 000 new cases of lung cancer occur worldwide every year , most of them due to smoking .", + "entities": [] + }, + { + "id": "412", + "type": "gene", + "text": "Restriction enzyme and heteroduplex analyses confirmed that sequences unique to FeSV ( src sequences ) are located at the center of the FeSV genome and are approximately 1 . 5 kilobase pairs in length .", + "entities": [ + "src sequences" + ] + }, + { + "id": "413", + "type": "gene", + "text": "Indium - 111 leukocyte imaging in patients with rheumatoid arthritis .", + "entities": [] + }, + { + "id": "414", + "type": "gene", + "text": "Thus , methylation of Pph21p is important for formation of PP2A trimeric and dimeric complexes , and consequently , for PP2A function .", + "entities": [ + "Pph21p", + "PP2A trimeric and dimeric complexes", + "PP2A" + ] + }, + { + "id": "415", + "type": "gene", + "text": "The in vitro activity of mecillinam and amoxicillin / clavulanic acid against Escherichia coli strains producing beta - lactamases of the TEM - 1 , Oxa - 1 and chromosomal type were studied using the broth and agar dilution technique .", + "entities": [ + "beta - lactamases", + "TEM - 1", + "Oxa - 1" + ] + }, + { + "id": "416", + "type": "gene", + "text": "Lithium - carbonate action during radiation therapy has been studied , valuing the positive effect on leukopoiesis and the consequent better clinical conditions of the patients in course of treatment .", + "entities": [] + }, + { + "id": "417", + "type": "gene", + "text": "The in vivo profile of ZFH - 2 in the larval CNS shows intriguing overlap with DDC in specific serotonin and dopamine neurons .", + "entities": [ + "ZFH - 2", + "DDC" + ] + }, + { + "id": "418", + "type": "gene", + "text": "The c - myc gene is overexpressed in a variety of tumor types and appears to play an important role in the abnormal growth of a number of cell types .", + "entities": [ + "c - myc gene" + ] + }, + { + "id": "419", + "type": "gene", + "text": "This study was carried out to analyze PRL secretion in metastatic prostate cancer patients both at basal conditions and in response to L - Dopa and metoclopramide , which represents the most classical inhibitory and stimulatory tests for PRL secretion , respectively .", + "entities": [ + "PRL", + "PRL" + ] + }, + { + "id": "420", + "type": "gene", + "text": "Pneumonia in children", + "entities": [] + }, + { + "id": "421", + "type": "gene", + "text": "When excluding children with ocular and cerebral pathology , 32 matched pairs of premature and control children remained .", + "entities": [] + }, + { + "id": "422", + "type": "gene", + "text": "Here , we describe the isolation of bovine and rat GHF - 1 cDNA clones .", + "entities": [ + "bovine and rat GHF - 1 cDNA" + ] + }, + { + "id": "423", + "type": "gene", + "text": "We also compared the sequence with the partly homologous products of the S . cerevisiae genes TPS2 and TSL1 which code for the larger subunits of the trehalose synthase complex and with a TSL1 homologue , TPS3 , of unknown function .", + "entities": [ + "TPS2", + "TSL1", + "trehalose synthase complex", + "TSL1 homologue", + "TPS3" + ] + }, + { + "id": "424", + "type": "gene", + "text": "The JTc delta among the three groups did not differ as well : JTc delta of the VT group was 70 ms + / - 30 ms , the JTc delta of the PVC group was 60 msec + / - 25 msec , and the JTc delta of the control group was 70 ms + / - 30 ms .", + "entities": [] + }, + { + "id": "425", + "type": "gene", + "text": "We previously described two alanine cluster mutations , R77 to A ( R77A ) - K79A and E192A - E194A , which selectively inactivated the triphosphatase component .", + "entities": [] + }, + { + "id": "426", + "type": "gene", + "text": "Intracellular recordings were performed on the optic tectum of the carp in vitro .", + "entities": [] + }, + { + "id": "427", + "type": "gene", + "text": "We present a case of type II hyperbetalipoproteinemia in a patient whose diagnosis had been previously unrecognized , and who had previously been misdiagnosed with rheumatoid arthritis and later gout .", + "entities": [] + }, + { + "id": "428", + "type": "gene", + "text": "In a third experiment , a Chessmaster gradually increases the number of boards he can reproduce with higher than 70 % average accuracy to nine , replacing as many as 160 pieces correctly .", + "entities": [] + }, + { + "id": "429", + "type": "gene", + "text": "The structural analysis also demonstrated that the heterogeneity of the HDC mRNA is caused by an insertion of the seventh intron sequence and alternative use of the splicing acceptor site at the 12th exon .", + "entities": [ + "HDC mRNA" + ] + }, + { + "id": "430", + "type": "gene", + "text": "Significantly , the polymerase chain reaction results demonstrated that gene IV transcripts were associated with hepatic polysome fractions , indicating their active utilization in this tissue .", + "entities": [ + "gene IV transcripts" + ] + }, + { + "id": "431", + "type": "gene", + "text": "Repression of glucocorticoid receptor - mediated transcriptional activation by unliganded thyroid hormone receptor ( TR ) is TR isoform - specific .", + "entities": [ + "glucocorticoid receptor", + "thyroid hormone receptor", + "TR", + "TR" + ] + }, + { + "id": "432", + "type": "gene", + "text": "It has been suggested that members of this protein family exhibit both prolyl isomerase and chaperone activity .", + "entities": [ + "prolyl isomerase" + ] + }, + { + "id": "433", + "type": "gene", + "text": "Avian reproductive system : daily variations in responses to hormones .", + "entities": [] + }, + { + "id": "434", + "type": "gene", + "text": "The process has been applied to the river reclamation in Yangpu District of Shanghai City , China .", + "entities": [] + }, + { + "id": "435", + "type": "gene", + "text": "Contacts between Bacillus subtilis catabolite regulatory protein CcpA and amyO target site .", + "entities": [ + "CcpA", + "amyO" + ] + }, + { + "id": "436", + "type": "gene", + "text": "Thus , the consensus sequences for phosphatase regulation are 5 ' - GCACGTGGG - 3 ' and 5 ' - GCACGTTTT - 3 ' which differ from the binding sequences for the Cpflp protein required for transcription of the genes in methionine biosynthesis and for centromere function .", + "entities": [ + "Cpflp" + ] + }, + { + "id": "437", + "type": "gene", + "text": "Similar observations have been made previously for other genes .", + "entities": [] + }, + { + "id": "438", + "type": "gene", + "text": "Conversely , the central regions are highly variable .", + "entities": [] + }, + { + "id": "439", + "type": "gene", + "text": "We previously showed that the upstream promoter element of the yeast RP39A gene consists of these identical sequence motifs .", + "entities": [ + "yeast RP39A gene" + ] + }, + { + "id": "440", + "type": "gene", + "text": "An anatomical and histochemical study has been undertaken and as a result emphasis is given to recent hypotheses that suggest there are similarities with Type IV glycogen storage disease ( Andersen ' s disease ) which , although clinically distinct , has the same enzyme defect .", + "entities": [] + }, + { + "id": "441", + "type": "gene", + "text": "Deadenylation and decay of beta - globin mRNA in K562 cells is extraordinarily slow compared with NIH 3T3 cells , suggesting that the increased stability gained by beta - globin mRNA in K562 cells is mainly controlled at the deadenylation step .", + "entities": [ + "beta - globin mRNA", + "beta - globin mRNA" + ] + }, + { + "id": "442", + "type": "gene", + "text": "The effects of social isolation on morphine - induced locomotor activity were compared in : ( i ) animals with an intact hypothalamo - pituitary - adrenal ( HPA ) axis ; ( ii ) animals in which stress - induced corticosterone secretion was blocked by adrenalectomy .", + "entities": [] + }, + { + "id": "443", + "type": "gene", + "text": "The mechanism by which large molecules , such as the diphosphonate 99mTc - labeled EHDP or 99mTc - labeled pyrophosphate , pass through capillaries in bone is by passive diffusion .", + "entities": [] + }, + { + "id": "444", + "type": "gene", + "text": "Since the - 172 / - 148 element also conferred estrogen and thyroid hormone responsiveness , it can be considered a composite hormone response element .", + "entities": [] + }, + { + "id": "445", + "type": "gene", + "text": "Moreover , we observed that the function of T3R - RXR heterodimers on response elements composed of two half - sites in a directly repeated orientation spaced by 4 nucleotides is determined in major parts by the 5 ' - flanking sequence of the upstream half - site .", + "entities": [ + "T3R", + "RXR" + ] + }, + { + "id": "446", + "type": "gene", + "text": "PLUS - 3 is a new Swedish protocol of natural speech in 3 - year - old children .", + "entities": [] + }, + { + "id": "447", + "type": "gene", + "text": "TbRAB31 behaviour was also studied during the cell cycle ; TbRAB31 always localised to a discrete structure that duplicated very early in mitosis and relocated to daughter cells in a coordinate manner with the basal body and kinetoplast , suggesting the involvement of microtubules .", + "entities": [ + "TbRAB31", + "TbRAB31" + ] + }, + { + "id": "448", + "type": "gene", + "text": "The histidine - tagged gene , rpoCHIS , was used to replace the wild - type allele in the chromosome of S . coelicolor and S . lividans .", + "entities": [ + "rpoCHIS" + ] + }, + { + "id": "449", + "type": "gene", + "text": "On the other hand , total pinealectomy in these already sympathectomized blinded rabbits always resulted in a substantial deceleration of the rhythms ( mean delta tau = + 0 . 23 h ) .", + "entities": [] + }, + { + "id": "450", + "type": "gene", + "text": "A malignant true teratoma of liver in childhood .", + "entities": [] + }, + { + "id": "451", + "type": "gene", + "text": "The enzyme activities studied are important elements in the pathophysiology of dental caries and may even be addressed as virulence factors .", + "entities": [] + }, + { + "id": "452", + "type": "gene", + "text": "Alternatively processed isoforms of cellular nucleic acid - binding protein interact with a suppressor region of the human beta - myosin heavy chain gene .", + "entities": [ + "cellular nucleic acid - binding protein", + "human beta - myosin heavy chain gene" + ] + }, + { + "id": "453", + "type": "gene", + "text": "The inhibition by the RIalpha subunit is reversed by addition of nanomolar concentrations of cAMP ( Ka = 40 nM ) , thus demonstrating that PrKX is a novel , type I cAMP - dependent protein kinase that is activated at lower cAMP concentrations than the holoenzyme with the Calpha subunit of cAMP - dependent protein kinase .", + "entities": [ + "RIalpha subunit", + "PrKX", + "type I cAMP - dependent protein kinase", + "Calpha subunit", + "cAMP - dependent protein kinase" + ] + }, + { + "id": "454", + "type": "gene", + "text": "These IgG antibodies in the babies diminished rapidly after delivery , and were detectable only in 3 cases at 2 , 3 , and 5 months of ages out of 38 babies up to 21 months .", + "entities": [ + "IgG antibodies" + ] + }, + { + "id": "455", + "type": "gene", + "text": "Dopamine neurons in subjects that received 6 - OHDA were protected by pre - treatment with GBR - 12909 .", + "entities": [] + }, + { + "id": "456", + "type": "gene", + "text": "In this study , we used footprinting and gel mobility retardation assays to reveal that bacterially synthesized Zta fusion proteins bound directly to six TGTGCAA - like motifs within DSL .", + "entities": [ + "Zta fusion proteins", + "DSL" + ] + }, + { + "id": "457", + "type": "gene", + "text": "After giving a survey on the situation of antibiotic resistance in the region of Northern Bavaria during 1973 / 74 and comparing the activity of a sulfamethoxazole ( SMZ ) trimethoprim ( TMP ) combination to other commonly used antibiotics and chemotherapeutic agents , the results of tests with the new combination of N1 - ( 4 , 5 - dimethyl - 2 - oxazolyl ) - sulfanilamide ) ( sulfamoxole ) and 2 , 4 - diamino - 5 - ( 3 , 4 , 5 - trimethoxy - benzyl ) - pyrimidine ( trimethoprim ) at a ratio of 5 : 1 ( CN 3123 ; Nevin , Supristol ) are compared to those of tests with TMP / SMZ .", + "entities": [] + }, + { + "id": "458", + "type": "gene", + "text": "Nuclear localization and protein sequence similarities suggested that the SPT2 / SIN1 protein may be related to the nonhistone chromosomal protein HMG1 .", + "entities": [ + "SPT2", + "SIN1", + "nonhistone chromosomal protein HMG1" + ] + }, + { + "id": "459", + "type": "gene", + "text": "Three cysteine and four tryptophan residues , previously identified as conserved amongst nitrous - oxide reductases , are found in the Paracoccus enzyme .", + "entities": [ + "nitrous - oxide reductases" + ] + }, + { + "id": "460", + "type": "gene", + "text": "Aberrant protein phosphorylation at tyrosine is responsible for the growth - inhibitory action of pp60v - src expressed in the yeast Saccharomyces cerevisiae .", + "entities": [ + "pp60v - src" + ] + }, + { + "id": "461", + "type": "gene", + "text": "The diagnosis of HCV arthritis in patients with positive rheumatoid factor and chronic inflammatory polyarthritis may be difficult .", + "entities": [ + "rheumatoid factor" + ] + }, + { + "id": "462", + "type": "gene", + "text": "Furthermore , the over - replication phenotype produced by this mutant p65cdc18 is resistant to increased mitotic cyclin / CDK activity , a known inhibitor of over - replication .", + "entities": [ + "mutant p65cdc18", + "cyclin", + "CDK" + ] + }, + { + "id": "463", + "type": "gene", + "text": "The lacS gene was cloned in an E . coli - Streptococcus shuttle vector and was expressed both in a lacS deletion derivative of S . thermophilus and in a pNZ63 - cured strain , L . lactis NZ6091 .", + "entities": [ + "lacS gene", + "lacS" + ] + }, + { + "id": "464", + "type": "gene", + "text": "The combination of MISO and WR - 2721 gave an intermediate response compared with either drug used alone , resulting in some sensitization with single doses and an overall protection with repeated small doses .", + "entities": [] + }, + { + "id": "465", + "type": "gene", + "text": "The insulin - induced DNA - binding complex was identified as the p50 / p65 heterodimer .", + "entities": [ + "insulin", + "p50", + "p65" + ] + }, + { + "id": "466", + "type": "gene", + "text": "Longitudinal force - length relationships of guinea pig ureter were studied in vitro in animals 3 weeks , 3 months , and 3 years of age .", + "entities": [] + }, + { + "id": "467", + "type": "gene", + "text": "A novel cDNA clone termed R2 was isolated by subtractive hybridization of a cDNA library of phytohemagglutinin ( PHA ) / phorbol myristate acetate - stimulated Jurkat cells and by rescreening a cDNA library of PHA - stimulated peripheral blood lymphocytes .", + "entities": [ + "phytohemagglutinin", + "PHA" + ] + }, + { + "id": "468", + "type": "gene", + "text": "These observed drug interactions , plus the known effect of probenecid to block secretion of PZA , have to be considered in evaluating the effect of the two drugs given together , compared to the effect of each drug given separately .", + "entities": [] + }, + { + "id": "469", + "type": "gene", + "text": "Analyses of tyrosine residue - mutated PDGF receptors show that Src homology 2 domain - containing proteins including Src family kinases , phosphatidylinositol 3 - kinase , the GTPase - activating protein of Ras , the Src homology 2 domain - containing phosphatase SHP - 2 , phospholipase C - gamma , and Crk do not play a major role in mediating the PDGF - induced activation of p38 .", + "entities": [ + "PDGF receptors", + "Src homology 2 domain - containing proteins", + "Src family kinases", + "phosphatidylinositol 3 - kinase", + "GTPase - activating protein", + "Ras", + "SHP - 2", + "phospholipase C - gamma", + "Crk", + "PDGF", + "p38" + ] + }, + { + "id": "470", + "type": "gene", + "text": "FTF is also abundantly expressed in the pancreas and may exert differentiation functions in endodermal sublineages , similar to SF - 1 in steroidogenic tissues .", + "entities": [ + "FTF", + "SF - 1" + ] + }, + { + "id": "471", + "type": "gene", + "text": "We suggest that FlgN and FliT are substrate - specific flagellar chaperones that prevent oligomerization of the HAPs by binding to their helical domains before export .", + "entities": [ + "FlgN", + "FliT", + "HAPs" + ] + }, + { + "id": "472", + "type": "gene", + "text": "Sequencing revealed one large open reading frame encoding a 39 - kDa protein .", + "entities": [] + }, + { + "id": "473", + "type": "gene", + "text": "The SCH9 protein kinase mRNA contains a long 5 ' leader with a small open reading frame .", + "entities": [ + "SCH9 protein kinase mRNA" + ] + }, + { + "id": "474", + "type": "gene", + "text": "Large interpatient variation in peak PCZ plasma levels ( 91 - 3215 ng / ml ) was seen , with the plasma half - life ( t1 / 2 alpha ) being approximately 57 min in patients given 135 - 180 mg / m2 PCZ .", + "entities": [] + }, + { + "id": "475", + "type": "gene", + "text": "Forty - eight 10 - 12 - week - old male Sprague - Dawley rats were randomized to receive , daily for 28 days : ( 1 ) CsA vehicle p . o . plus FB vehicle sc ; ( 2 ) CsA ( 15 mg / kg ) p . o . plus FB vehicle sc , ( 3 ) CsA vehicle p . o . plus FB ( 1 . 5 mg / kg ) sc ; and ( 4 ) CsA ( 15 mg / kg ) p . o . plus FB ( 1 . 5 mg / kg ) sc .", + "entities": [] + }, + { + "id": "476", + "type": "gene", + "text": "A false positive marker screen was associated with the occurrence of hand - foot syndrome even when the effect of regimen was accounted for by stratification ( p = . 01 ) .", + "entities": [] + }, + { + "id": "477", + "type": "gene", + "text": "Subcloning of DNA fragments from the 8 . 5 - kilobase ( kb ) insert of pAVO4 defined a 4 - kb DNA fragment which contained the functional FBP + gene and its regulatory region .", + "entities": [ + "functional FBP + gene" + ] + }, + { + "id": "478", + "type": "gene", + "text": "General formulae for estimating heritability in a population with related parents .", + "entities": [] + }, + { + "id": "479", + "type": "gene", + "text": "One such mutant also affects the overlapping - 10 hexamer of PR and results in reduced occupancy by both MerR and RNA polymerase , likely as a result of inefficient transcriptional initiation of merR mRNA .", + "entities": [ + "MerR", + "RNA polymerase", + "merR mRNA" + ] + }, + { + "id": "480", + "type": "gene", + "text": "LDL cholesterol decreased from 4 . 74 + / - 0 . 87 to 3 . 78 + / - 0 . 78 mmol / l after 8 weeks on simvastatin ( P < 0 . 001 ) , and apo B fell from 142 + / - 31 to 112 + / - 22 mg / dl ( P < 0 . 001 ) .", + "entities": [ + "LDL cholesterol", + "apo B" + ] + }, + { + "id": "481", + "type": "gene", + "text": "Egd1p is homologous to human BTF3b , recently identified as the beta subunit of the heterodimeric nascent - polypeptide - associated complex ( NAC ) involved in ensuring signal - sequence - specific protein sorting and translocation [ Wiedmann et al . , Nature 370 ( 1994 ) 434 - 440 ] .", + "entities": [ + "Egd1p", + "human BTF3b", + "heterodimeric nascent - polypeptide - associated complex", + "NAC" + ] + }, + { + "id": "482", + "type": "gene", + "text": "LDL cholesterol decreased from 4 . 74 + / - 0 . 87 to 3 . 78 + / - 0 . 78 mmol / l after 8 weeks on simvastatin ( P < 0 . 001 ) , and apo B fell from 142 + / - 31 to 112 + / - 22 mg / dl ( P < 0 . 001 ) .", + "entities": [ + "LDL cholesterol", + "apo B" + ] + }, + { + "id": "483", + "type": "gene", + "text": "Revascularization after anterior maxillary and mandibular osteotomy", + "entities": [] + }, + { + "id": "484", + "type": "gene", + "text": "Nuclear - encoded chloroplast ribosomal protein L12 of Nicotiana tabacum : characterization of mature protein and isolation and sequence analysis of cDNA clones encoding its cytoplasmic precursor .", + "entities": [ + "Nuclear - encoded chloroplast ribosomal protein L12 of Nicotiana tabacum" + ] + }, + { + "id": "485", + "type": "gene", + "text": "These findings indicate that autophosphorylation of Thr286 ( alpha subunit ) and Thr287 ( beta subunit ) is responsible for transition of CaM - kinase II to the Ca2 + - independent form .", + "entities": [ + "CaM - kinase II" + ] + }, + { + "id": "486", + "type": "gene", + "text": "We did not observe any changes in Bcl - 2 or Bcl - 2 - related proteins ( Bcl - x , Bax , and Bad ) in control or KCREB - transfected cells before or after treatment with Tg .", + "entities": [ + "Bcl - 2", + "Bcl - 2 - related proteins", + "Bcl - x", + "Bax", + "Bad", + "KCREB" + ] + }, + { + "id": "487", + "type": "gene", + "text": "Acute stress in 7 rats also increased the mean amount of IL - 6 released in the urine by 31 . 5 % from 775 . 9 + / - 69 . 2 to 1 , 021 . 1 + / - 93 . 3 pg . / ml .", + "entities": [ + "IL - 6" + ] + }, + { + "id": "488", + "type": "gene", + "text": "9 . 7 ( 95 % CI : 9 . 6 - 9 . 7 ) micromol / L among women ( P = 0 . 003 ) .", + "entities": [] + }, + { + "id": "489", + "type": "gene", + "text": "This study indicated that the Japanese quail was less sensitive to particulate Mn3O4 exposure than rodents treated comparably .", + "entities": [] + }, + { + "id": "490", + "type": "gene", + "text": "Analysis of human genomic DNA reveals an intronless sequence with strong homology to human G alpha q cDNA .", + "entities": [ + "human G alpha q cDNA" + ] + }, + { + "id": "491", + "type": "gene", + "text": "Observation of dipolar interactions between Pb0 defects at the ( 111 ) Si / SiO2 interface .", + "entities": [] + }, + { + "id": "492", + "type": "gene", + "text": "RESULTS : Horses with colic had significantly higher fibrinogen concentration , greater alpha 2AP and protein C activities , and longer PT and APTT than did healthy horses .", + "entities": [ + "fibrinogen", + "alpha 2AP", + "protein C" + ] + }, + { + "id": "493", + "type": "gene", + "text": "The Prolactin levels were within the physiological norms ; the responses to TRH were normal , and elevated only in a few cases .", + "entities": [ + "Prolactin", + "TRH" + ] + }, + { + "id": "494", + "type": "gene", + "text": "Skeletal muscle metaboreceptor exercise responses are attenuated in heart failure .", + "entities": [] + }, + { + "id": "495", + "type": "gene", + "text": "Recently , identical RBE sequences have been identified at other locations in the human genome .", + "entities": [ + "RBE sequences" + ] + }, + { + "id": "496", + "type": "gene", + "text": "Using Spurr ' s resin as a mounting medium , we could observe thick specimens with oil immersion objective lens without the use of coverslips , then avoid air bubbles near the specimen .", + "entities": [] + }, + { + "id": "497", + "type": "gene", + "text": "BACKGROUND : We conducted a phase I study with MDL 73 , 147EF , a new 5 hydroxytryptamine 3 ( 5 - HT3 ) receptor antagonist , in 25 patients requiring emetogenic chemotherapy .", + "entities": [ + "5 hydroxytryptamine 3 ( 5 - HT3 ) receptor" + ] + }, + { + "id": "498", + "type": "gene", + "text": "Modulation of AUUUA response element binding by heterogeneous nuclear ribonucleoprotein A1 in human T lymphocytes .", + "entities": [ + "heterogeneous nuclear ribonucleoprotein A1" + ] + }, + { + "id": "499", + "type": "gene", + "text": "The selective alteration of the genome using Cre recombinase to target the rearrangement of genes flanked by LOX recognition sequences has required the use of two separate genetic constructs in trans , one containing cre and the other containing the gene of interest flanked by LOX sites .", + "entities": [ + "Cre recombinase", + "LOX recognition sequences", + "LOX sites" + ] + }, + { + "id": "500", + "type": "gene", + "text": "The gene is separated into four exons by three short introns , and the open reading frame consists of 6660 base pairs ( bp ) capable of encoding a polypeptide of 2220 amino acid residues .", + "entities": [] + }, + { + "id": "501", + "type": "gene", + "text": "Cardiac taurine levels and sarcolemmal calcium binding activity in furazolidone - induced cardiomyopathy .", + "entities": [] + }, + { + "id": "502", + "type": "gene", + "text": "The effects of diltiazem were stereoselective , thus the potentiation induced by d - cis diltiazem was significantly greater in all cases than that induced by l - cis diltiazem , which suggests that calcium channel blockade plays a role in these interactions .", + "entities": [] + }, + { + "id": "503", + "type": "gene", + "text": "Simple models of bimolecular interaction did not fully account for the kinetic profiles obtained with the parental antibodies and the hybrids , and this complexity suggested the existence of a conformational heterogeneity in these molecules .", + "entities": [] + }, + { + "id": "504", + "type": "gene", + "text": "Electronic data processing ( EDP ) latex immunoassay using anti - human seminal acid phosphatase ( anti - HSAP ) immune serum was applied for the species and organ identification of human seminal stains .", + "entities": [ + "anti - human seminal acid phosphatase", + "anti - HSAP" + ] + }, + { + "id": "505", + "type": "gene", + "text": "DNA blot hybridization suggests that the rat genome may contain more than one gene encoding PtdIns transfer protein .", + "entities": [ + "PtdIns transfer protein" + ] + }, + { + "id": "506", + "type": "gene", + "text": "A randomized , prospective study was conducted to compare ovarian stimulation with human menopausal gonadotropin ( hMG ) and human follicle - stimulating hormone ( hFSH ) in an in vitro fertilization and embryo transfer ( IVF - ET ) program .", + "entities": [ + "human menopausal gonadotropin", + "hMG", + "human follicle - stimulating hormone", + "hFSH" + ] + }, + { + "id": "507", + "type": "gene", + "text": "The R2 between MFI of fresh and frozen muscle was 0 . 94 and 0 . 92 for lamb and pork longissimus , respectively .", + "entities": [] + }, + { + "id": "508", + "type": "gene", + "text": "Panlobular emphysema", + "entities": [] + }, + { + "id": "509", + "type": "gene", + "text": "M - Ras interacted poorly in a yeast two - hybrid assay with multiple Ras effectors , including c - Raf - 1 , A - Raf , B - Raf , phosphoinositol - 3 kinase delta , RalGDS , and Rin1 .", + "entities": [ + "M - Ras", + "Ras", + "c - Raf - 1", + "A - Raf", + "B - Raf", + "phosphoinositol - 3 kinase delta", + "RalGDS", + "Rin1" + ] + }, + { + "id": "510", + "type": "gene", + "text": "Hydrophobicity analysis indicated that the KlaA and KlaB polypeptides are likely to be soluble , whereas the KlaC polypeptide was predicted to have four potential membrane - spanning domains .", + "entities": [ + "KlaA", + "KlaB polypeptides", + "KlaC polypeptide" + ] + }, + { + "id": "511", + "type": "gene", + "text": "Comparison of the genomic DNA sequence with that of the four different mRNAs indicates that these transcripts are produced by alternative splicing of the murine pre - mRNA according to a cassette model .", + "entities": [] + }, + { + "id": "512", + "type": "gene", + "text": "Thyrotoxicosis due to amiodarone is difficult to treat and is further complicated by the pro - arrhythmic potential of thyrotoxicosis and the fading antiarrhythmic effect after amiodarone withdrawal .", + "entities": [] + }, + { + "id": "513", + "type": "gene", + "text": "Separation of ninhydrin - positive compounds in urine by the combined methods of medium - tension intophoresis and partition chromatography", + "entities": [] + }, + { + "id": "514", + "type": "gene", + "text": "Recently , we discovered that alanine substitutions of the active center cleft residues significantly impair the depurinating and ribosome inhibitory activity of PAP .", + "entities": [ + "PAP" + ] + }, + { + "id": "515", + "type": "gene", + "text": "Review : deterioration of glucose tolerance with age : the role of insulin resistance .", + "entities": [ + "insulin" + ] + }, + { + "id": "516", + "type": "gene", + "text": "The two mouse lines carrying the unfragmented Hnf3g - lacZ YAC showed tissue - specific , copy number - dependent and position - independent expression , proving that 170 kb of the Hnf3g locus contain all elements important in the regulation of Hnf3g .", + "entities": [ + "Hnf3g", + "lacZ", + "Hnf3g", + "Hnf3g" + ] + }, + { + "id": "517", + "type": "gene", + "text": "Further , the ORFs of components 3 and 5 potentially encoded proteins of about 20 kDa , the size of the BBTV coat protein .", + "entities": [ + "BBTV coat protein" + ] + }, + { + "id": "518", + "type": "gene", + "text": "CONCLUSION : Although quantitative and qualitative criteria for diagnosing fatty liver on helical CT can be determined , they are protocol - specific .", + "entities": [] + }, + { + "id": "519", + "type": "gene", + "text": "In this study , the general clinical criteria for inhalation injury - - presence of facial or oropharyngeal burns , carboxyhemoglobin levels , carbonaceous sputum , or closed space injury - - did not differentiate patients with airway injury only from those with parenchymal injury .", + "entities": [ + "carboxyhemoglobin" + ] + }, + { + "id": "520", + "type": "gene", + "text": "In turn , assembly of this complex mediates the enzymatic activation of the p21 - activated protein kinase 1 and facilitates actin polymerization .", + "entities": [ + "p21 - activated protein kinase 1", + "actin" + ] + }, + { + "id": "521", + "type": "gene", + "text": "These repressor sites are pyrimidine rich and bind avidly to the polypyrimidine tract binding protein ( PTB ) in HeLa nuclear extracts as determined by UV crosslinking / competition assays .", + "entities": [ + "polypyrimidine tract binding protein", + "PTB" + ] + }, + { + "id": "522", + "type": "gene", + "text": "Cardiac preservation .", + "entities": [] + }, + { + "id": "523", + "type": "gene", + "text": "Evaluation of thyroid function .", + "entities": [] + }, + { + "id": "524", + "type": "gene", + "text": "Analysis of the DNA from 15 cases of sporadic and familial Wilms ' tumor did not reveal any changes , indicating that the translocation breakpoint does not reside in this gene .", + "entities": [] + }, + { + "id": "525", + "type": "gene", + "text": "These two mRNA species are produced by differential polyadenylation site usage .", + "entities": [] + }, + { + "id": "526", + "type": "gene", + "text": "During ISO + AT infusion , abdominal fat blood flow was still significantly increased as compared with control values in lean and obese subjects .", + "entities": [] + }, + { + "id": "527", + "type": "gene", + "text": "Rats underwent either a 90 - 95 % JIB or a sham operation .", + "entities": [] + }, + { + "id": "528", + "type": "gene", + "text": "The recovery of labelled methoxydextrane is 98 + / - 7 % .", + "entities": [] + }, + { + "id": "529", + "type": "gene", + "text": "Our findings suggest that the mtr product causes both transcription attenuation and inhibition of translation of trpE mRNA .", + "entities": [ + "mtr product", + "trpE mRNA" + ] + }, + { + "id": "530", + "type": "gene", + "text": "In the ePTFE specimens , tissue coverage had increased .", + "entities": [] + }, + { + "id": "531", + "type": "gene", + "text": "No anisotropism was recorded in a tetrahydrofuran solution .", + "entities": [] + }, + { + "id": "532", + "type": "gene", + "text": "A method is described for detecting targeted events at the mu heavy chain gene which relies on co - conversion ( or co - exchange ) of a point mutation with a selectable marker contained on a replacement vector .", + "entities": [ + "mu heavy chain gene" + ] + }, + { + "id": "533", + "type": "gene", + "text": "The ipiO genes code for two almost identical 152 - aa proteins which do not have any homology with sequences present in data libraries .", + "entities": [ + "ipiO genes" + ] + }, + { + "id": "534", + "type": "gene", + "text": "Human expressed sequence tag clones were identified by sequence similarity to mammalian and yeast oligosaccharide - processing mannosidases , and the full - length coding region of the putative mannosidase homolog was isolated by a combination of 5 ' - rapid amplification of cDNA ends and direct polymerase chain reaction from human placental cDNA .", + "entities": [ + "mammalian and yeast oligosaccharide - processing mannosidases", + "mannosidase homolog" + ] + }, + { + "id": "535", + "type": "gene", + "text": "Urease activity of 97 % of these organisms became evident within 30 min .", + "entities": [ + "Urease" + ] + }, + { + "id": "536", + "type": "gene", + "text": "Serum levels of IgG and IgM were also raised , but contrary to the findings of other observers IgA levels were normal .", + "entities": [ + "IgG", + "IgM", + "IgA" + ] + }, + { + "id": "537", + "type": "gene", + "text": "The results indicate that the pooling requirements are task dependent .", + "entities": [] + }, + { + "id": "538", + "type": "gene", + "text": "SETTING : A division of a large tea plantation in Kandy .", + "entities": [] + }, + { + "id": "539", + "type": "gene", + "text": "Twenty - eight ( 7 . 0 % ) infants without periventricular hemorrhage were revealed as having spastic cerebral palsy by neurodevelopmental evaluation in later infancy .", + "entities": [] + }, + { + "id": "540", + "type": "gene", + "text": "These results indicate that an internal short element located at the very 5 ' terminal of L1 sequence and the nuclear factor binding to the element play a crucial role in the transcription of human L1 .", + "entities": [ + "L1 sequence", + "human L1" + ] + }, + { + "id": "541", + "type": "gene", + "text": "In the evening , the amplitude of the responses to both O2 and CO2 increased but the increase in CO2 sensitivity was proportionally more important .", + "entities": [] + }, + { + "id": "542", + "type": "gene", + "text": "This study utilizes the mammalian two - hybrid system to examine the role of ligand in the dimerization of human progesterone receptor ( hPR ) .", + "entities": [ + "human progesterone receptor", + "hPR" + ] + }, + { + "id": "543", + "type": "gene", + "text": "A more complete analysis of dose response , time and mode of Ga administration ( preinjury or postinjury ) , and availability of Ga across the blood - brain barrier is needed to further evaluate the efficacy of this compound .", + "entities": [] + }, + { + "id": "544", + "type": "gene", + "text": "The C - terminal mature region is highly conserved in other serine carboxypeptidases .", + "entities": [ + "serine carboxypeptidases" + ] + }, + { + "id": "545", + "type": "gene", + "text": "Galphaq , Galpha12 , and Galpha13 , but not Galphai , activate SRF through RhoA .", + "entities": [ + "Galphaq", + "Galpha12", + "Galpha13", + "Galphai", + "SRF", + "RhoA" + ] + }, + { + "id": "546", + "type": "gene", + "text": "The most frequent risk factor for ischaemic was hypertension .", + "entities": [] + }, + { + "id": "547", + "type": "gene", + "text": "In Saccharomyces cerevisiae , PHO85 encodes a cyclin - dependent protein kinase ( Cdk ) catalytic subunit with multiple regulatory roles thought to be specified by association with different cyclin partners ( Pcls ) .", + "entities": [ + "PHO85", + "cyclin - dependent protein kinase", + "Cdk", + "cyclin", + "Pcls" + ] + }, + { + "id": "548", + "type": "gene", + "text": "In addition , they display common features that make them strikingly related to snoRNA U14 .", + "entities": [ + "snoRNA U14" + ] + }, + { + "id": "549", + "type": "gene", + "text": "Several different oncogenes and growth factors promote G1 phase progression .", + "entities": [] + }, + { + "id": "550", + "type": "gene", + "text": "Chem .", + "entities": [] + }, + { + "id": "551", + "type": "gene", + "text": "To do this , segments of DNA from the 5 ' flank of the initiation sites for germline epsilon RNA were ligated to a luciferase reporter gene and transfected into two mouse B cell lines , one of which can be induced to switch to IgE .", + "entities": [ + "luciferase reporter gene", + "IgE" + ] + }, + { + "id": "552", + "type": "gene", + "text": "Wegener ' s granulomatosis", + "entities": [] + }, + { + "id": "553", + "type": "gene", + "text": "The ZnF20 cDNA hybridized to multiple transcripts in a thyroid cancer cell line ( 8 . 0 , 4 . 5 and 2 kb ) that increased after cycloheximide treatment and decayed < 2 h after addition of actinomycin D .", + "entities": [ + "ZnF20 cDNA" + ] + }, + { + "id": "554", + "type": "gene", + "text": "Effect of hyperglycemia on pain threshold in alloxan - diabetic rats .", + "entities": [] + }, + { + "id": "555", + "type": "gene", + "text": "Nine new naphthalene related compounds ( I , IV , V , VII - XII ) together with four known compounds ( II , III , VI , XIII ) were isolated from the root bark of Oroxylum indicum Vent .", + "entities": [] + }, + { + "id": "556", + "type": "gene", + "text": "We conclude that the beta - adrenergic agonist , isoproterenol , has little influence on vascular capacitance or liver volume of dogs , unless the hepatic outflow resistance is elevated by agents such as histamine .", + "entities": [] + }, + { + "id": "557", + "type": "gene", + "text": "Nevertheless , inactivation of the cyclin E - Cdk2 complex in response to mitogen starvation occurs normally in MEFs that have a homozygous deletion of the p27 gene .", + "entities": [ + "cyclin E", + "Cdk2", + "p27 gene" + ] + }, + { + "id": "558", + "type": "gene", + "text": "One month after the DTaP booster vaccination , both groups had 6 - to 40 - fold increases in serum antibody concentrations to all antigens tested ; the concentrations against the three pertussis antigens were higher in the DTaP - primed children ( p < 0 . 05 ) .", + "entities": [ + "pertussis antigens" + ] + }, + { + "id": "559", + "type": "gene", + "text": "On the constituents of Dryopteris polylepis", + "entities": [] + }, + { + "id": "560", + "type": "gene", + "text": "The cases included 35 de novo diffuse aggressive lymphomas ( DAL ; 19 large - cell , 4 mixed - cell , and 12 large - cell immunoblastic ) , 52 transformed aggressive lymphomas derived from follicular lymphomas ( TFL ) , 42 indolent follicular lymphomas ( FL ) , 14 mantle cell lymphomas ( MCL ) , and 27 small noncleaved cell lymphomas ( SNCL ) .", + "entities": [] + }, + { + "id": "561", + "type": "gene", + "text": "Idiopathic bilateral recurrent branch retinal arterial occlusion ( IBRBRAO ) is a rare syndrome characterized by migraine headaches , tinnitus , vertigo , hearing loss , and recurrent branch retinal artery occlusion of unknown etiology .", + "entities": [] + }, + { + "id": "562", + "type": "gene", + "text": "Such transgenic plants should enable not only the mutational analysis of sequence elements within the replication origin region , but also the construction of a new generation of vectors for gene amplification in plants , based on a minimal virus replicon .", + "entities": [] + }, + { + "id": "563", + "type": "gene", + "text": "The mysteries of geographic variability in nonmelanoma skin cancer incidence .", + "entities": [] + }, + { + "id": "564", + "type": "gene", + "text": "Only transcripts specific for TSGF - 2 are detected in ovary and testes tissues of adults as well as in puparia , while neither gene is expressed during the larval developmental stages .", + "entities": [ + "TSGF - 2" + ] + }, + { + "id": "565", + "type": "gene", + "text": "Expression of class IV ADH mRNA was detected in human stomach but not liver .", + "entities": [ + "class IV ADH mRNA" + ] + }, + { + "id": "566", + "type": "gene", + "text": "Leptinaemia does not correlate with the actual or mean blood pressure reading nor with stage of hypertension according to the WHO classification .", + "entities": [] + }, + { + "id": "567", + "type": "gene", + "text": "Next , we show that two EMS - induced mutations , previously shown to interact genetically with zipper ( Ebr ) , disrupt the RhoA locus .", + "entities": [ + "Ebr", + "RhoA locus" + ] + }, + { + "id": "568", + "type": "gene", + "text": "The presence of local abnormalities in both patients can support the hypothesis that the cortex , especially of the temporal anterior lobe , is involved in the origin of the laughing seizures .", + "entities": [] + }, + { + "id": "569", + "type": "gene", + "text": "A controlled trial of recombinant human granulocyte - macrophage colony - stimulating factor after total body irradiation , high - dose chemotherapy , and autologous bone marrow transplantation for acute lymphoblastic leukemia or malignant lymphoma .", + "entities": [ + "recombinant human granulocyte - macrophage colony - stimulating factor" + ] + }, + { + "id": "570", + "type": "gene", + "text": "T - cell receptor beta ( TCR beta ) gene rearrangements occur in a third of early B - cell acute lymphoblastic leukemias ( ALLs ) .", + "entities": [ + "T - cell receptor beta", + "TCR beta" + ] + }, + { + "id": "571", + "type": "gene", + "text": "Lung density increased in quartz - exposed , but not in volcanic - ash - exposed animals .", + "entities": [] + }, + { + "id": "572", + "type": "gene", + "text": "The morphological effects of two snake venoms , N . naja and A . piscivorus , and of the Direct Lytic Factor and Phospholipase - A , compounds purified from N . naja crude venom , were investigated on lung and cremaster vessels of rats .", + "entities": [ + "Direct Lytic Factor", + "Phospholipase - A" + ] + }, + { + "id": "573", + "type": "gene", + "text": "The IL - 8 receptor is a seven - transmembrane spanning receptor coupled to specific heterotrimeric G proteins including Gi and G16 .", + "entities": [ + "IL - 8 receptor", + "heterotrimeric G proteins", + "Gi", + "G16" + ] + }, + { + "id": "574", + "type": "gene", + "text": "Atorvastatin was the most cost - effective HMG - CoA reductase inhibitor .", + "entities": [ + "HMG - CoA reductase" + ] + }, + { + "id": "575", + "type": "gene", + "text": "Gel retardation assays combined with DNase I footprinting and diethyl pyrocarbonate interference showed that a nuclear factor from differentiated C2 myotubes and BC3H1 myocytes recognized a conserved A + T - rich sequence within the peripheral activating region .", + "entities": [ + "DNase I" + ] + }, + { + "id": "576", + "type": "gene", + "text": "The size of the mutant molecule corresponds to the unprocessed cytoplasmic precursor ( pre - super - pro - PrB ) , as detected in sec61 mutants , when translocation into the endoplasmic reticulum is blocked .", + "entities": [ + "pre - super - pro - PrB", + "sec61 mutants" + ] + }, + { + "id": "577", + "type": "gene", + "text": "OBJECTIVE : To determine the efficacy and safety of amphotericin B oral suspension ( ABOS ) for the treatment of fluconazole refractory oral candidiasis in persons with HIV infection .", + "entities": [] + }, + { + "id": "578", + "type": "gene", + "text": "In simpler organisms , the ATP sulfurylase and APS kinase reactions are catalyzed by separate enzymes encoded by two or three genes , suggesting that a fusion of separate genes during the course of evolution generated the bifunctional enzyme .", + "entities": [ + "ATP sulfurylase", + "APS kinase" + ] + }, + { + "id": "579", + "type": "gene", + "text": "Investigations using hippocampal slices maintained in vitro have demonstrated that bursts of oscillatory field potentials in the gamma frequency range ( 30 - 80 Hz ) are followed by a slower oscillation in the beta 1 range ( 12 - 20 Hz ) .", + "entities": [] + }, + { + "id": "580", + "type": "gene", + "text": "The actA gene is present as a single copy in the genome of A . chrysogenum ; and its expression level , opposite to pcbC and cefEF cephalosporin biosynthetic genes , was steady during cephalosporin fermentation , showing a single 1 . 4 - kb transcript .", + "entities": [ + "actA gene", + "pcbC", + "cefEF cephalosporin biosynthetic genes" + ] + }, + { + "id": "581", + "type": "gene", + "text": "After nerve injury , the nociceptive responses through type I neurons , which are polymodal C - fibers and drive NK1 - receptor mechanisms in spinal pain transmission , were completely lost , but without changes in type II ones , which are polymodal C - fibers and drive NMDA receptor - mechanisms , while type III ones , which are capsaicin - insensitive ( possibly A - fibers ) and drive NMDA - receptor mechanisms , were markedly enhanced .", + "entities": [ + "NK1 - receptor", + "NMDA receptor", + "NMDA - receptor" + ] + }, + { + "id": "582", + "type": "gene", + "text": "The absorbed dose was measured by combination of two integrating detectors : thermo - luminescent dosemeter of Mg2SiO4 : Tb ( TDMS ) and plastic nuclear track detector ( PNTD ) .", + "entities": [] + }, + { + "id": "583", + "type": "gene", + "text": "To compare the PAX3 and putative PAX3 - FKHR transactivation domains , we fused C - terminal test fragments to the heterologous GAL4 DNA - binding domain and tested activation of a reporter gene co - transfected into four cell types .", + "entities": [ + "PAX3", + "PAX3", + "FKHR", + "GAL4 DNA - binding domain" + ] + }, + { + "id": "584", + "type": "gene", + "text": "Viscosity experiments on the catalytic fragment kinase reaction demonstrated that the chemical ( phosphoryl transfer ) step had a reduced rate .", + "entities": [] + }, + { + "id": "585", + "type": "gene", + "text": "Excision repair at the level of the nucleotide in the Saccharomyces cerevisiae MFA2 gene : mapping of where enhanced repair in the transcribed strand begins or ends and identification of only a partial rad16 requisite for repairing upstream control sequences .", + "entities": [ + "Saccharomyces cerevisiae MFA2 gene", + "rad16" + ] + }, + { + "id": "586", + "type": "gene", + "text": "It was shown that estradiol concentrations obtained after estradiol valerate and micronized estradiol ingestion were dependent on the patient ' s age as well as on the constitutional type .", + "entities": [] + }, + { + "id": "587", + "type": "gene", + "text": "This study compared the gross and fine motor performance of 14 traumatically brain - injured children ( five to 15 years old , with loss of consciousness for at least 24 hours ) to 14 normal children group matched for age and sex .", + "entities": [] + }, + { + "id": "588", + "type": "gene", + "text": "Serum magnesium in 79 patients of gynecologic neoplasms treated with cisplatin and their controls was measured .", + "entities": [] + }, + { + "id": "589", + "type": "gene", + "text": "PURPOSE : The purposes of the present study were to assess the effects of a 12 - wk laboratory based aerobic exercise program on cardiopulmonary function , CD4 cell count , and physician - assessed health status among symptomatic pre - AIDS HIV - infected individuals ( N = 28 ) and to assess the degree to which ill health was associated with exercise relapse .", + "entities": [ + "CD4" + ] + }, + { + "id": "590", + "type": "gene", + "text": "Five women ( 15 . 6 % ) met criteria for PMS .", + "entities": [] + }, + { + "id": "591", + "type": "gene", + "text": "Described X - ray projection were performed in 70 patients .", + "entities": [] + }, + { + "id": "592", + "type": "gene", + "text": "Identification of dynein heavy chain genes expressed in human and mouse testis : chromosomal localization of an axonemal dynein gene .", + "entities": [ + "dynein heavy chain genes", + "axonemal dynein gene" + ] + }, + { + "id": "593", + "type": "gene", + "text": "In contrast , the Anabaena strain 7120 leuA gene did not complement the nifV mutation of R229I efficiently .", + "entities": [ + "leuA", + "nifV mutation" + ] + }, + { + "id": "594", + "type": "gene", + "text": "Only 17 % of all patients admitted it at all times .", + "entities": [] + }, + { + "id": "595", + "type": "gene", + "text": "There is no TATA box appropriately spaced upstream from the transcription initiation site .", + "entities": [] + }, + { + "id": "596", + "type": "gene", + "text": "Based on the comparison of the predicted amino acid sequences of 1 - sst and 1 - fft with those of other plant fructosyl transferase genes , we postulate that both plant fructan genes have evolved from plant invertase genes .", + "entities": [ + "1 - sst", + "1 - fft", + "fructosyl transferase genes", + "fructan genes", + "invertase" + ] + }, + { + "id": "597", + "type": "gene", + "text": "The present findings revealed that the rib - 2 protein was a unique alpha1 , 4 - N - acetylglucosaminyltransferase involved in the biosynthetic initiation and elongation of heparan sulfate .", + "entities": [ + "rib - 2 protein", + "alpha1 , 4 - N - acetylglucosaminyltransferase" + ] + }, + { + "id": "598", + "type": "gene", + "text": "After transfection , specific TSH beta promoter activity was evident in both TRH - responsive pituitary - derived GH3 and primary pituitary cell cultures .", + "entities": [ + "TSH beta promoter", + "TRH" + ] + }, + { + "id": "599", + "type": "gene", + "text": "Additional exonuclease III protection was observed beyond the core region on both the 5 ' and 3 ' sides , suggesting that E1 interacted with more distal sequences as well .", + "entities": [ + "exonuclease III", + "E1" + ] + }, + { + "id": "600", + "type": "gene", + "text": "The cDNA corresponding to the FPS1 gene was isolated by functional complementation of a mutant yeast strain defective in FPS activity ( Delourme , D . , Lacroute , F . , and Karst , F .", + "entities": [ + "FPS1 gene", + "FPS" + ] + }, + { + "id": "601", + "type": "gene", + "text": "Ketanserin , a hypotensive drug with 5 - HT2 receptor antagonism , when administered by topical infusion of a 0 . 25 % w / v solution by corneal and scleral applications , was found to lower intraocular pressure with four times more activity than its metabolite , ketanserinol .", + "entities": [ + "5 - HT2 receptor" + ] + }, + { + "id": "602", + "type": "gene", + "text": "The known B1 - deficiency reaches excessive high values with light exercise .", + "entities": [] + }, + { + "id": "603", + "type": "gene", + "text": "We have examined by in vitro footprinting a region located downstream of the human immunodeficiency virus , type 1 ( HIV - 1 ) promoter found to be hypersensitive to DNase I digestion in vivo .", + "entities": [ + "DNase I" + ] + }, + { + "id": "604", + "type": "gene", + "text": "Furthermore , in vivo and in vitro protein - protein interaction experiments have shown that SR33 protein interacts with itself and with SR45 protein but not with two other members ( SRZ21 and SRZ22 ) of the SR family that are known to interact with the Arabidopsis full - length U - 70K only .", + "entities": [ + "SR33 protein", + "SR45 protein", + "SRZ21", + "SRZ22", + "SR family", + "U - 70K" + ] + }, + { + "id": "605", + "type": "gene", + "text": "Furthermore , heparin lyase treatment of extracts of cells expressing recombinant YD - repeat protein releases this protein from high molecular mass aggregates .", + "entities": [ + "heparin lyase", + "recombinant YD - repeat protein" + ] + }, + { + "id": "606", + "type": "gene", + "text": "Phosphorylation and spindle pole body localization of the Cdc15p mitotic regulatory protein kinase in budding yeast .", + "entities": [ + "Cdc15p mitotic regulatory protein kinase in budding yeast" + ] + }, + { + "id": "607", + "type": "gene", + "text": "The management of the \" chronic \" patient .", + "entities": [] + }, + { + "id": "608", + "type": "gene", + "text": "These data suggest that RPF - 1 is likely to be involved in early steps in the differentiation of amacrine and ganglion cells .", + "entities": [ + "RPF - 1" + ] + }, + { + "id": "609", + "type": "gene", + "text": "Since the integrated 13h00 - 16h00 plasma cortisol estimation is cheaper and simpler than the mean 13h00 - 16h00 plasma cortisol estimation , we recommend it as an adjunct in the diagnosis of Cushing ' s syndrome .", + "entities": [] + }, + { + "id": "610", + "type": "gene", + "text": "The 4 - AP ( 4 - 20 mM ) effect resulted in a decrease of the sensory activity , which was fully restored by TEA or Ba2 + .", + "entities": [] + }, + { + "id": "611", + "type": "gene", + "text": "Disruption of microtubules did not affect the fidelity or kinetics of vacuolar protein sorting , indicating that Vps1p function is not dependent on microtubules .", + "entities": [ + "Vps1p" + ] + }, + { + "id": "612", + "type": "gene", + "text": "When comparing the barley PSI - K and PSI - G with the reported PSI - K sequence from Synechococcus vulcanus , the degree of similarity is equal , suggesting that an ancestral gene has been duplicated in a chloroplast progenitor but not in a cyanobacterial .", + "entities": [ + "barley PSI - K", + "PSI - G", + "PSI - K sequence from Synechococcus vulcanus" + ] + }, + { + "id": "613", + "type": "gene", + "text": "The RS447 human megasatellite tandem repetitive sequence encodes a novel deubiquitinating enzyme with a functional promoter .", + "entities": [ + "human megasatellite tandem repetitive sequence" + ] + }, + { + "id": "614", + "type": "gene", + "text": "Value of Normotest and antithrombin 3 in the assessment of liver function .", + "entities": [ + "antithrombin 3" + ] + }, + { + "id": "615", + "type": "gene", + "text": "RESULTS : Of the 29 patients who received concurrent chemotherapy and G - CSF , ten ( 34 % ; 95 % confidence interval [ CI ] , 17 . 9 to 54 . 3 % ) were believed to have clinically significant bleomycin toxicity .", + "entities": [ + "G - CSF" + ] + }, + { + "id": "616", + "type": "gene", + "text": "Prevention by a heparin - antithrombin III combination", + "entities": [ + "antithrombin III" + ] + }, + { + "id": "617", + "type": "gene", + "text": "However , at 18 months of age , significantly higher levels of IgG1 ( P less than 0 . 05 ) and of IgG4 ( P less than 0 . 01 ) were found in infants with an elevated IgE ( greater than or equal to 8 . 0 kU / l ) than in those with a lower level .", + "entities": [ + "IgG1", + "IgG4", + "IgE" + ] + }, + { + "id": "618", + "type": "gene", + "text": "To study the role of heavy chain motifs in substrate recognition , secreted variants of recombinant bovine proenteropeptidase were constructed by replacing the transmembrane domain with a signal peptide .", + "entities": [ + "recombinant bovine proenteropeptidase" + ] + }, + { + "id": "619", + "type": "gene", + "text": "Chem .", + "entities": [] + }, + { + "id": "620", + "type": "gene", + "text": "A third one is homologous in half of its length to the prokaryotic hydantoinase HyuA and in the other half to hydatoinase HyuB .", + "entities": [ + "HyuA", + "HyuB" + ] + }, + { + "id": "621", + "type": "gene", + "text": "Five additional copies of Lian elements were isolated , mapped by restriction digestion , and partially sequenced .", + "entities": [ + "Lian elements" + ] + }, + { + "id": "622", + "type": "gene", + "text": "Hybridization of a probe from this region to electrophoretic blots of RNAs from different human tissues showed a predominant 2 . 8 - kilobase ( kb ) message accompanied by weaker bands 4 . 1 and 2 . 1 kb in size .", + "entities": [] + }, + { + "id": "623", + "type": "gene", + "text": "Kinase - deficient erbB proteins reduced epidermal growth factor ( EGF ) - induced tyrosine phosphorylation of endogenous Shc proteins and also reduced immediate and sustained EGF - induced ERK MAPK activities in human glioblastoma cells , although basal ERK MAPK activities were unaffected .", + "entities": [ + "erbB proteins", + "epidermal growth factor", + "EGF", + "Shc proteins", + "EGF - induced ERK MAPK", + "ERK MAPK" + ] + }, + { + "id": "624", + "type": "gene", + "text": "Together , the data suggest that cAMP - dependent control of the amounts of the activator SF - 1 vs . the repressor COUP - TF could influence CRS2 - dependent transcription .", + "entities": [ + "SF - 1", + "COUP - TF" + ] + }, + { + "id": "625", + "type": "gene", + "text": "In wild - type cells , SSM1b transcripts accumulate to twice the level of SSM1a transcripts , suggesting that SSM1b is responsible for the majority of the Ssm1p pool .", + "entities": [ + "SSM1b transcripts", + "SSM1a transcripts", + "SSM1b", + "Ssm1p" + ] + }, + { + "id": "626", + "type": "gene", + "text": "This paper describes the genomic organization of mouse gC1qBP and the characterization of its 5 ' flanking region .", + "entities": [ + "gC1qBP" + ] + }, + { + "id": "627", + "type": "gene", + "text": "As a result of alternative splicing , the BGP gene is transcribed into at least seven distinct mRNA species .", + "entities": [ + "BGP gene" + ] + }, + { + "id": "628", + "type": "gene", + "text": "Although large epidemiologic studies are best able to identify the relative contributions of specific risk factors while controlling for other risk factors , new studies need to focus on important unresolved questions .", + "entities": [] + }, + { + "id": "629", + "type": "gene", + "text": "Patients were divided into two group ; Control group A in which a hot - water circulating system was used and group B in which a transtracheal heating and humidification system by ANAMED HUMITUBE was used , during gastric cancer operation .", + "entities": [] + }, + { + "id": "630", + "type": "gene", + "text": "Apart from antimicrobial properties , recent data indicate that PMN also exert anti - inflammatory effects by stimulation and release of cytokine antagonists such as interleukin - 1 receptor antagonist ( IL - 1ra ) .", + "entities": [ + "interleukin - 1 receptor antagonist", + "IL - 1ra" + ] + }, + { + "id": "631", + "type": "gene", + "text": "Incubation of the purified fusion proteins with [ gamma - 32P ] ATP in an in vitro assay showed that both proteins were capable of autophosphorylation .", + "entities": [] + }, + { + "id": "632", + "type": "gene", + "text": "Oxygen delivery and consumption and P50 in patients with acute myocardial infarction .", + "entities": [] + }, + { + "id": "633", + "type": "gene", + "text": "Metal coordination compounds of thiabendazole .", + "entities": [] + }, + { + "id": "634", + "type": "gene", + "text": "Total body water , rhodanide space and I - 131 - albumin space under the acute effect of furosemide", + "entities": [ + "I - 131 - albumin" + ] + }, + { + "id": "635", + "type": "gene", + "text": "Thus it appears that insertion of a transposable element near the 5 ' terminus of the structural gene can produce constitutive expression of a normally glucose - repressed enzyme .", + "entities": [] + }, + { + "id": "636", + "type": "gene", + "text": "Northern and RT - PCR analysis of Ube3a expression in mouse tissues from animals with segmental , paternal uniparental disomy failed to detect substantially reduced or absent expression compared to control animals , failing to provide any evidence for maternal - specific expression from this locus .", + "entities": [ + "Ube3a" + ] + }, + { + "id": "637", + "type": "gene", + "text": "Using RACE techniques we have cloned and sequenced one of the hamster liver 3 - hydroxy - hexobarbital dehydrogenases which catalyze not only cyclic alcohols but also 17beta - hydroxy - steroids and 3alpha - hydroxysteroids .", + "entities": [ + "3 - hydroxy - hexobarbital dehydrogenases" + ] + }, + { + "id": "638", + "type": "gene", + "text": "In the second case , an epidermal cyst was diagnosed .", + "entities": [] + }, + { + "id": "639", + "type": "gene", + "text": "Rats treated with 8 - OH - DPAT were not impaired in their ability to learn a visual discrimination in a water maze .", + "entities": [] + }, + { + "id": "640", + "type": "gene", + "text": "Effects of single and combined maltose tetrapalmitate immunotherapy , cyclophosphamide chemotherapy and radiotherapy on ethyl carbamate accelerated primary lung cancer in A / J mice .", + "entities": [] + }, + { + "id": "641", + "type": "gene", + "text": "GCN4 encodes a transcriptional activator of amino acid biosynthetic genes in Saccharomyces cerevisiae .", + "entities": [ + "GCN4" + ] + }, + { + "id": "642", + "type": "gene", + "text": "The frequency of previous transfusion in chronic hepatitis , cirrhosis and hepatocellular carcinoma of type NANB was 42 . 8 , 37 . 1 and 15 . 1 % , respectively , whereas the incidence of early posttransfusion hepatitis was 8 . 5 , 8 . 6 and 7 . 5 % , respectively . in chronic liver diseases with a history of jaundice and / or hepatitis , previous transfusions are more frequently associated with type NANB than with type B disease .", + "entities": [] + }, + { + "id": "643", + "type": "gene", + "text": "ArgR was shown to be a dimer of two equal subunits , each with a molecular mass of 37 , 000 Da .", + "entities": [ + "ArgR" + ] + }, + { + "id": "644", + "type": "gene", + "text": "ATP by itself also reduced polypeptide binding to Ssb1 / 2p to a level that was intermediate between that observed for the Ssa Hsp70 proteins tested and BiP and DnaK .", + "entities": [ + "Ssb1 / 2p", + "Hsp70 proteins", + "BiP", + "DnaK" + ] + }, + { + "id": "645", + "type": "gene", + "text": "This study was undertaken to evaluate how couplers and their placement affect the ALGO2 click spectral properties .", + "entities": [] + }, + { + "id": "646", + "type": "gene", + "text": "We show that c - Fos ( the c - fos protooncogene product ) , which is an intrinsically unstable nuclear protein , is metabolically highly stabilized , and greatly enhances the transforming efficiency of NIH 3T3 cells , by Mos .", + "entities": [ + "c - Fos", + "c - fos protooncogene product", + "Mos" + ] + }, + { + "id": "647", + "type": "gene", + "text": "Potential treatments include dobutamine , KATP channel activators , and 21 - aminosteroids .", + "entities": [] + }, + { + "id": "648", + "type": "gene", + "text": "The effect of ICRF - 187 on the antitumor response induced by the combination of ADR and WBH was also investigated in order to assess alterations in the therapeutic index of this combined therapeutic modality treatment .", + "entities": [] + }, + { + "id": "649", + "type": "gene", + "text": "The negative calcium balance with hyperparathyroidemia occurred after continuous oral administration of Cd and developed via increased urinary excretion of calcium .", + "entities": [] + }, + { + "id": "650", + "type": "gene", + "text": "A . , Swift , A .", + "entities": [] + }, + { + "id": "651", + "type": "gene", + "text": "The contrasting effects of dopaminergic stimulation on the motor performance and on some aspects of cognitive processing suggest the existence of complex interactions within pre - and postsynaptic brain dopamine receptors , and an intervention of segregated basal ganglia - prefrontal cortex loops in motor and cognitive behaviour .", + "entities": [ + "brain dopamine receptors" + ] + }, + { + "id": "652", + "type": "gene", + "text": "The histopathology and neovascularization did not appreciably differ between xenograft tumors derived from FGF4 over - expressing versus control transfectants .", + "entities": [ + "FGF4" + ] + }, + { + "id": "653", + "type": "gene", + "text": "Based on restriction enzyme analysis , Southern blots , polymerase chain reaction analysis and DNA sequencing , it was confirmed that the three overlapping clones isolated cover the entire cHO - 1 gene , as well as approximately 10 kb of the flanking regions on both ends .", + "entities": [ + "cHO - 1 gene" + ] + }, + { + "id": "654", + "type": "gene", + "text": "These mutant proteins retained the ability to competitively inhibit kappa B - mediated transcriptional activation of the human immunodeficiency virus long terminal repeat but failed to efficiently transform chicken lymphoid cells both in vitro and in vivo .", + "entities": [ + "kappa B", + "human immunodeficiency virus long terminal repeat" + ] + }, + { + "id": "655", + "type": "gene", + "text": "Effect of bromazepam on growth hormone and prolactin secretion in normal subjects .", + "entities": [ + "growth hormone", + "prolactin" + ] + }, + { + "id": "656", + "type": "gene", + "text": "In viral infections , G - CSF was correlated with mononuclear cells ( rs = 0 . 41 , P < 0 . 05 ) , white blood cell counts ( rs = 0 . 56 , P < 0 . 01 ) , neutrophils ( rs = 0 . 41 , P < 0 . 05 ) and CRP ( rs = 0 . 47 , P < 0 . 05 ) .", + "entities": [ + "G - CSF", + "CRP" + ] + }, + { + "id": "657", + "type": "gene", + "text": "The length scales of the turbulence were also estimated : at a Reynolds number near 4 , 000 the macroscale is about 1 . 25 mm , the Taylor microscale is about 0 . 85 mm , and the Kolmogoroff scale is near 0 . 075 mm .", + "entities": [] + }, + { + "id": "658", + "type": "gene", + "text": "METHODS : Fibrotic changes involving bone marrow were evaluated histologically semiquantitatively using reticulin fiber impregnation ( method of Gomori ) .", + "entities": [ + "reticulin" + ] + }, + { + "id": "659", + "type": "gene", + "text": "VIII in doses 2 - 3 times higher than usually used in haemophiliacs without inhibitor were successful .", + "entities": [] + }, + { + "id": "660", + "type": "gene", + "text": "As pH and Hb can also affect mixed venous CO2 content , the effect on Q was also assessed .", + "entities": [ + "Hb" + ] + }, + { + "id": "661", + "type": "gene", + "text": "A substantial fraction of Cbl was constitutively associated with Grb2 and this interaction was mediated by Grb2 SH3 domains .", + "entities": [ + "Cbl", + "Grb2", + "SH3" + ] + }, + { + "id": "662", + "type": "gene", + "text": "Activated areas have been identified by means of cross - correlation analysis .", + "entities": [] + }, + { + "id": "663", + "type": "gene", + "text": "Furthermore , the deletion of bcp from the chromosome had no effect on gcv - lacZ expression .", + "entities": [ + "bcp", + "gcv", + "lacZ" + ] + }, + { + "id": "664", + "type": "gene", + "text": "JCAHO revised interpretation", + "entities": [] + }, + { + "id": "665", + "type": "gene", + "text": "The mechanism underlying such analgesia has been suggested to involve the interaction between the two separate but interconnected motivational systems \" defense \" and \" pain . \" To determine the developmental course of defense and nociception , these processes were analyzed during early ontogeny in rats .", + "entities": [] + }, + { + "id": "666", + "type": "gene", + "text": "Location and orientation of an activating region in the Escherichia coli transcription factor , FNR .", + "entities": [ + "FNR" + ] + }, + { + "id": "667", + "type": "gene", + "text": "It was concluded , that on a given section , 75 , 7 per cent of the trabeculae were in contact with vascular cavities .", + "entities": [] + }, + { + "id": "668", + "type": "gene", + "text": "In electromobility shift assays , EWS - FLI - 1 binding to the SRE is detectable in the absence of SRF whereas the binding of FLI - 1 is not , suggesting that the interaction with DNA is the step which limits ternary complex formation by FLI - 1 .", + "entities": [ + "EWS", + "FLI - 1", + "SRF", + "FLI - 1", + "FLI - 1" + ] + }, + { + "id": "669", + "type": "gene", + "text": "A proportion of APC wild - type colon carcinomas and melanomas also contains constitutive nuclear Tcf - 4 / beta - catenin complexes as a result of dominant mutations in the N terminus of beta - catenin that render it insensitive to downregulation by APC , GSK3 beta , and Axin / Conductin .", + "entities": [ + "APC", + "Tcf - 4", + "beta - catenin", + "beta - catenin", + "APC", + "GSK3 beta", + "Axin", + "Conductin" + ] + }, + { + "id": "670", + "type": "gene", + "text": "Plasma ion changes in venous blood incubated with beta receptor blockers and subjected to tonometry in vitro .", + "entities": [ + "beta receptor" + ] + }, + { + "id": "671", + "type": "gene", + "text": "F - box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin - ligase complex .", + "entities": [ + "F - box proteins", + "ubiquitin", + "ligase" + ] + }, + { + "id": "672", + "type": "gene", + "text": "The former group did excrete less dry fecal material compared to both other groups .", + "entities": [] + }, + { + "id": "673", + "type": "gene", + "text": "The interaction of AF - 1 with proteins that regulate distinct steps of transcription may provide a mechanism for synergistic activation of gene expression by AF - 1 .", + "entities": [] + }, + { + "id": "674", + "type": "gene", + "text": "Fusion of ubiquitin to pADPRP increased the yield of pADPRP approximately 10 - fold compared to that of the unfused enzyme .", + "entities": [ + "ubiquitin", + "pADPRP", + "pADPRP" + ] + }, + { + "id": "675", + "type": "gene", + "text": "Each individual shot 25 bullets in about 5 minutes , at an intensity level calculated at 163 dB .", + "entities": [] + }, + { + "id": "676", + "type": "gene", + "text": "Symptomatic hyperventilators had a larger number of sighs and abnormally wide fluctuations in baseline for inspiratory time , expiratory time , and PETCO2 .", + "entities": [] + }, + { + "id": "677", + "type": "gene", + "text": "We determined whether the human StAR promoter is responsive to sterol regulatory element - binding proteins ( SREBPs ) .", + "entities": [ + "human StAR promoter", + "sterol regulatory element - binding proteins", + "SREBPs" + ] + }, + { + "id": "678", + "type": "gene", + "text": "We derive joint probability density distributions for three key uncertain properties of the climate system , using an optimal fingerprinting approach to compare simulations of an intermediate complexity climate model with three distinct diagnostics of recent climate observations .", + "entities": [] + }, + { + "id": "679", + "type": "gene", + "text": "To gain insight into the expression of the AtCP1 gene , northern blot analysis was carried out .", + "entities": [ + "AtCP1 gene" + ] + }, + { + "id": "680", + "type": "gene", + "text": "The model indicates that a 0 . 076 % reduction in cigarette consumption is associated with the availability of nicotine patches after 1992 .", + "entities": [] + }, + { + "id": "681", + "type": "gene", + "text": "With the human Rhotekin cDNA as a probe , Northern hybridization revealed that a 4 . 0 - kb transcript was expressed at a high level in prostate and at a middle level in 13 of 16 tissues examined , but it cannot be detected in liver and lung tissues .", + "entities": [ + "human Rhotekin cDNA" + ] + }, + { + "id": "682", + "type": "gene", + "text": "There was also a highly significant correlation between total selenium intake and liver selenium concentration ( r = 0 . 99 , p < 0 . 01 ) after 1 mo of treatment , but this time liver selenium did not change with time , and the correlation remained highly significant throughout the investigation .", + "entities": [] + }, + { + "id": "683", + "type": "gene", + "text": "Overlapping clones representing full - length cDNAs for MMI alpha were obtained from mouse brain .", + "entities": [ + "MMI alpha" + ] + }, + { + "id": "684", + "type": "gene", + "text": "Side effect including subjective and objective symptoms were strictly evaluated in 163 cases ( KS - R1 group in 83 cases , oral group in 80 cases ) , but the incidence rate which was 22 . 9 % for the KS - R1 group and 23 . 8 % for the oral group showed no significant difference .", + "entities": [] + }, + { + "id": "685", + "type": "gene", + "text": "Spores from Rhizopus stolonifer were suspended in distilled water ( 1 x 10 ( 6 ) spores / mL ) and used as starter .", + "entities": [] + }, + { + "id": "686", + "type": "gene", + "text": "This open reading frame was confirmed the correct one by direct amino - terminal sequence analysis of the overproduced msgB gene product .", + "entities": [ + "msgB gene product" + ] + }, + { + "id": "687", + "type": "gene", + "text": "The application of ultrafiltration to sample preparation in the detection and quantification of ethylene glycol in plasma by gas chromatography is described .", + "entities": [] + }, + { + "id": "688", + "type": "gene", + "text": "A total of 1060 clones were randomly selected for sequencing of one end .", + "entities": [] + }, + { + "id": "689", + "type": "gene", + "text": "Genetic alterations in elements of normal signal transduction mechanisms are known to be oncogenic events often resulting in aberrant activation of programs of gene transcription .", + "entities": [] + }, + { + "id": "690", + "type": "gene", + "text": "This inhibitory domain has been deleted in all naturally occurring AHC deletion mutants described to date .", + "entities": [ + "AHC deletion mutants" + ] + }, + { + "id": "691", + "type": "gene", + "text": "The 5 ' end of the coding region was located precisely by comparing the deduced amino acid sequence to the actual N - terminal amino acid sequence of IHF .", + "entities": [ + "IHF" + ] + }, + { + "id": "692", + "type": "gene", + "text": "Because the deletion included the TK gene , selection with gancyclovir against cells not having undergone recombination was possible .", + "entities": [ + "TK gene" + ] + }, + { + "id": "693", + "type": "gene", + "text": "The dopamine D4 receptor as well as many other catecholaminergic receptors contain several putative SH3 binding domains .", + "entities": [ + "dopamine D4 receptor", + "catecholaminergic receptors", + "SH3 binding domains" + ] + }, + { + "id": "694", + "type": "gene", + "text": "Cutaneous necrosis associated with protein S deficiency .", + "entities": [ + "protein S" + ] + }, + { + "id": "695", + "type": "gene", + "text": "Pentachlorophenol accelerates the onset of HCB porphyria , in other words it increases the total urinary porphyrin excretion and causes an earlier disturbance of the porphyrin pattern .", + "entities": [] + }, + { + "id": "696", + "type": "gene", + "text": "The hydrophobicity plot of NHE - 3 is very similar to that of NHE - 1 and NHE - 2 .", + "entities": [ + "NHE - 3", + "NHE - 1", + "NHE - 2" + ] + }, + { + "id": "697", + "type": "gene", + "text": "Until such investigations are performed , we conclude that the role for adjuvant treatment is questionable and that TME surgery is preferred as the treatment option for Stage T1 - T3 rectal cancers .", + "entities": [] + }, + { + "id": "698", + "type": "gene", + "text": "We describe here 17 dominant GCN2 mutations that lead to derepression of GCN4 expression in the absence of amino acid starvation .", + "entities": [ + "dominant GCN2 mutations", + "GCN4" + ] + }, + { + "id": "699", + "type": "gene", + "text": "In a maxicell system a protein with an approximate molecular weight of 36 , 000 was synthesized .", + "entities": [] + }, + { + "id": "700", + "type": "gene", + "text": "An activation - responsive element in single C motif - 1 / lymphotactin promoter is a site of constitutive and inducible DNA - protein interactions involving nuclear factor of activated T cell .", + "entities": [ + "single C motif - 1", + "lymphotactin" + ] + }, + { + "id": "701", + "type": "gene", + "text": "Bile bilirubin did not rise within 12 h after haem infusion a finding which warrants further investigation .", + "entities": [] + }, + { + "id": "702", + "type": "gene", + "text": "Army veterans given yellow fever vaccine contaminated with hepatitis B virus in 1942 and controls and ( b ) a case - control study comparing veterans with hepatocellular carcinoma in Veterans Affairs hospitals with matched controls with respect to receipt of contaminated vaccine in 1942 .", + "entities": [] + }, + { + "id": "703", + "type": "gene", + "text": "Engagement of human CD2 by mitogenic pairs of anti - CD2 mAb induces tyrosine phosphorylation of a number of intracellular proteins including a 120 kDa phosphoprotein that we identify as the proto - oncogene c - Cbl .", + "entities": [ + "human CD2", + "anti - CD2 mAb", + "proto - oncogene c - Cbl" + ] + }, + { + "id": "704", + "type": "gene", + "text": "The role of pharmacological profiling in safety assessment .", + "entities": [] + }, + { + "id": "705", + "type": "gene", + "text": "The dying tTG - transfected cells exhibit both cytoplasmic and nuclear changes characteristic of cells undergoing apoptosis .", + "entities": [ + "tTG" + ] + }, + { + "id": "706", + "type": "gene", + "text": "Serum PTH tended to increase in the WL group but not in the WM group ( P < 0 . 06 ) .", + "entities": [ + "Serum PTH" + ] + }, + { + "id": "707", + "type": "gene", + "text": "The ether phospholipid 1 - O - octadecyl - 2 - O - methyl - rac - glycero - 3 - phosphocholine ( ET - 18 - OCH3 ; edelfosine ) is a potent inducer of apoptosis in human tumor cells .", + "entities": [] + }, + { + "id": "708", + "type": "gene", + "text": "Removal of thick , permanently altered mucoas is recommended even in the absence of squamous epithelium .", + "entities": [] + }, + { + "id": "709", + "type": "gene", + "text": "Analysis of the entire 16 . 7 - kb mt genome determined that a MDP1 mediates cleavage of chick mtDNA in vitro at three H - and two L - strand sequence - specific target sites located within a 90 - bp A + T - rich genomic tract , theoretically capable of forming stable secondary structures , approximately 200 bases upstream from the H - strand origin ( OH ) of replication .", + "entities": [ + "MDP1" + ] + }, + { + "id": "710", + "type": "gene", + "text": "Aedes aegypti ( L . ) and Aedes albopictus ( Skuse ) in Singapore City .", + "entities": [] + }, + { + "id": "711", + "type": "gene", + "text": "We have improved our system for nuclear contour digitization and determined its theoretical limitations by digitizing standardized objects .", + "entities": [] + }, + { + "id": "712", + "type": "gene", + "text": "Site - directed mutagenesis of the R2 protein was used to provide evidence that this motif is also part of the active site of the endonuclease encoded by this element .", + "entities": [ + "R2 protein" + ] + }, + { + "id": "713", + "type": "gene", + "text": "We have determined the molecular lesions of nine Scm mutant alleles , which identify functional requirements for specific domains .", + "entities": [ + "Scm mutant alleles" + ] + }, + { + "id": "714", + "type": "gene", + "text": "The application of these microelectrodes to the measurement of rapid , transient changes in retinal [ K + ] o is presented .", + "entities": [] + }, + { + "id": "715", + "type": "gene", + "text": "Examination of the MMP - 2 RE1 sequence revealed an incomplete Y - box sequence ( CTGCTGGGCAAG ) , which specifically interacted with recombinant YB - 1 on DMS protection footprinting analysis .", + "entities": [ + "MMP - 2 RE1 sequence", + "recombinant YB - 1" + ] + }, + { + "id": "716", + "type": "gene", + "text": "MAIN OUTCOME MEASURE ( S ) : Serum levels of FSH , LH , and inhibin A and B .", + "entities": [ + "FSH", + "LH", + "inhibin A and B" + ] + }, + { + "id": "717", + "type": "gene", + "text": "Baseline measurements of forced expiratory volume in 1 s ( FEV1 ) , specific airway conductance ( SGaw ) and the provocative dose of carbachol causing a 35 % reduction in SGaw ( PD35 ) , and a 20 % reduction in FEV1 ( PD20 ) were established on entry while each subject was still smoking .", + "entities": [] + }, + { + "id": "718", + "type": "gene", + "text": "YAC and cosmid contigs spanning the Batten disease ( CLN3 ) region at 16p12 . 1 - p11 . 2 .", + "entities": [ + "Batten disease", + "CLN3" + ] + }, + { + "id": "719", + "type": "gene", + "text": "CyIIa transcription follows , and is therefore downstream of , the initial specification of these embryonic domains .", + "entities": [ + "CyIIa" + ] + }, + { + "id": "720", + "type": "gene", + "text": "RESULTS : Twenty - two ( 26 % ) patients had PHG before ( group A ) and 64 ( 74 % ) developed PHG after variceal eradication ( group B ) .", + "entities": [] + }, + { + "id": "721", + "type": "gene", + "text": "In contrast , capsid proteins derived from the P1 precursor with a valine substitution at the amino terminus of VP1 ( VP1 - G001V ) assembled empty capsid particles but were deficient in assembling RNA - containing virions .", + "entities": [ + "capsid proteins", + "P1 precursor", + "VP1", + "VP1 - G001V" + ] + }, + { + "id": "722", + "type": "gene", + "text": "These data suggest that the levels of oxygen free radicals were increased in hepatocytes and mitochondria .", + "entities": [] + }, + { + "id": "723", + "type": "gene", + "text": "Endurance training resulted in an increase of stiffness associated with a decrease of type II fibers .", + "entities": [] + }, + { + "id": "724", + "type": "gene", + "text": "The CEM receives registration updates via an HL7 message and evaluates data dependencies in rules via an interface to the relational database .", + "entities": [] + }, + { + "id": "725", + "type": "gene", + "text": "Effects of intramammary endotoxin infusion on milking - induced oxytocin release .", + "entities": [ + "oxytocin" + ] + }, + { + "id": "726", + "type": "gene", + "text": "As was observed previously for MATa cna1 cna2 double mutants , MATa cnb1 mutants were defective in their ability to recover from alpha - factor - induced growth arrest .", + "entities": [ + "cna2", + "cnb1 mutants", + "alpha - factor" + ] + }, + { + "id": "727", + "type": "gene", + "text": "Previous studies have shown [ Hisanaga , S . , Kusubata , M . , Okumura , E .", + "entities": [] + }, + { + "id": "728", + "type": "gene", + "text": "& Kishimoto , T .", + "entities": [] + }, + { + "id": "729", + "type": "gene", + "text": "Apoptosis of small cells is still observed after co - transfection of JBD and LMP1 but in addition a few apoptotic HD - MyZ cells with large fused nuclear masses are identified suggesting that specific inhibition of JNK leads also to apoptosis of LMP1 induced RS cells .", + "entities": [ + "JBD", + "LMP1", + "JNK", + "LMP1" + ] + }, + { + "id": "730", + "type": "gene", + "text": "The numerous tests demonstrate that the HDL - 2M can be extensively and successfully used for therapy of insulin - dependent diabetes mellitus in clinical practice .", + "entities": [ + "insulin" + ] + }, + { + "id": "731", + "type": "gene", + "text": "Point mutations in the third SH3 domain abolished the vinexin - Sos interaction .", + "entities": [ + "SH3 domain", + "vinexin", + "Sos" + ] + }, + { + "id": "732", + "type": "gene", + "text": "The Nmd3 protein sequence does not contain readily recognizable motifs of known function .", + "entities": [ + "Nmd3 protein sequence" + ] + }, + { + "id": "733", + "type": "gene", + "text": "Depleted and enriched U3O8 standard reference materials were used to calibrate the system .", + "entities": [] + }, + { + "id": "734", + "type": "gene", + "text": "After declamping of the aorta , there were also severe edema , local fibre necrosis , and adhesion of leucocytes , whereas muscle fibre areas became 3 , 935 . 18 micro 531 microm ( 2 ) for type I and 5 , 804 + / - 1 , 075 microm ( 2 ) for type II .", + "entities": [] + }, + { + "id": "735", + "type": "gene", + "text": "In contrast , recent evidence suggests that children with sickle - hemoglobin C disease do not develop functional asplenia before 3 to 4 years of age and thus may not benefit from penicillin prophylaxis .", + "entities": [ + "sickle - hemoglobin C" + ] + }, + { + "id": "736", + "type": "gene", + "text": "Heterogeneous nuclear ribonucleoprotein ( hnRNP ) core protein A1 is a major component of mammalian hnRNP 40 S particles .", + "entities": [ + "Heterogeneous nuclear ribonucleoprotein ( hnRNP ) core protein A1", + "mammalian hnRNP 40 S particles" + ] + }, + { + "id": "737", + "type": "gene", + "text": "[ 14C ] - beta - phenethylamine , its distribution after administration by various routes to cats , and the effects of monoamine oxidase inhibitors .", + "entities": [ + "monoamine oxidase" + ] + }, + { + "id": "738", + "type": "gene", + "text": "MSSP proteins have been identified by their binding to an upstream element of c - myc .", + "entities": [ + "MSSP proteins", + "c - myc" + ] + }, + { + "id": "739", + "type": "gene", + "text": "Diagnosis of unilateral renal artery lesions after captopril administration .", + "entities": [] + }, + { + "id": "740", + "type": "gene", + "text": "Biological evaluation of mibolerone in the female Beagle .", + "entities": [] + }, + { + "id": "741", + "type": "gene", + "text": "Two disulphide bridges , which are conserved in all spermadhesin molecules and many CUB domains , crosslink loop LA and strand beta 4 and loops LE and LG , respectively , at opposite edges of the same face of the domain .", + "entities": [] + }, + { + "id": "742", + "type": "gene", + "text": "High levels of IC coincided with relative hypocomplementemia .", + "entities": [] + }, + { + "id": "743", + "type": "gene", + "text": "However , essential contrast differences existing between the FSE sequences and their routine asymmetric dual SE counterpart can be identified .", + "entities": [] + }, + { + "id": "744", + "type": "gene", + "text": "Sex ratio at birth .", + "entities": [] + }, + { + "id": "745", + "type": "gene", + "text": "The effects of coenzyme Q10 ( CoQ ) and captopril on functional capacity , hemodynamics and survival were studied in 154 rats that recovered after experimental myocardial infarction .", + "entities": [] + }, + { + "id": "746", + "type": "gene", + "text": "This review seeks to summarize the disease , to propose pathways of carcinogenesis and to suggest ways in which the \" traditional \" risk factors may be interpreted on the basis of evolving knowledge .", + "entities": [] + }, + { + "id": "747", + "type": "gene", + "text": "Dietetics of childhood - and juvenile diabetes", + "entities": [] + }, + { + "id": "748", + "type": "gene", + "text": "The highly conserved ninth heptad , which is involved in heterodimerization , appears to participate in the receptor - inhibitor interaction , suggesting that the inhibitor is a related member of the receptor gene family .", + "entities": [] + }, + { + "id": "749", + "type": "gene", + "text": "The negative regulatory activity of the N - terminal domain was antagonized by a C - terminal segment of Pho81p supplied in trans .", + "entities": [ + "Pho81p" + ] + }, + { + "id": "750", + "type": "gene", + "text": "SUMMARY BACKGROUND DATA : Melanoma care has not changed significantly in the last 20 years , and the controversy of elective lymph node dissections in this disease continues to be discussed .", + "entities": [] + }, + { + "id": "751", + "type": "gene", + "text": "The carboxyl - terminal portion of UKLF contains three zinc fingers of the Cys2 - His2 type and binds in vitro to the CACCC motif of the beta - globin promoter and to the Sp1 recognition sequence .", + "entities": [ + "UKLF", + "beta - globin promoter", + "Sp1 recognition sequence" + ] + }, + { + "id": "752", + "type": "gene", + "text": "The protein was associated with purified vaccinia virus particles and with membranes of immature and mature virions that were visualized by electron microscopy of infected cells .", + "entities": [] + }, + { + "id": "753", + "type": "gene", + "text": "At a PaCO2 of 40 mmHg , baseline brain pHi measured 7 . 03 + / - 0 . 04 , while regional cortical blood flow was 47 . 0 + / - 4 . 3 ml . 100 g - 1 . min - 1 .", + "entities": [] + }, + { + "id": "754", + "type": "gene", + "text": "We have identified two functional elements , both located downstream from the TATA motif , that control Id4 promoter activity .", + "entities": [ + "Id4 promoter" + ] + }, + { + "id": "755", + "type": "gene", + "text": "Spasmus nutans : a syndrome of auto - arousal .", + "entities": [] + }, + { + "id": "756", + "type": "gene", + "text": "Diagnosis of prostatic carcinoma : the yield of serum prostate specific antigen , digital rectal examination and transrectal ultrasonography .", + "entities": [ + "serum prostate specific antigen" + ] + }, + { + "id": "757", + "type": "gene", + "text": "Model of spatiotemporal dynamics of stick - slip motion .", + "entities": [] + }, + { + "id": "758", + "type": "gene", + "text": "How many embryos to transfer in patients undergoing IVF ?", + "entities": [] + }, + { + "id": "759", + "type": "gene", + "text": "Thrombosis of the renal vein may be dramatic and include renal failure .", + "entities": [] + }, + { + "id": "760", + "type": "gene", + "text": "Effects of estrogen and glucocorticoids on the adrenal development of the fetus .", + "entities": [] + }, + { + "id": "761", + "type": "gene", + "text": "We also identified an alternative spliced form of Lyp RNA , Lyp2 .", + "entities": [ + "Lyp RNA", + "Lyp2" + ] + }, + { + "id": "762", + "type": "gene", + "text": "We have investigated the influence of NaFe3 + EDTA , and of increasing dietary levels of Na2EDTA , on Zn , Cu and Ca metabolism in rats fed on Zn - sufficient and Zn - deficient soya - bean - isolate - based diets .", + "entities": [] + }, + { + "id": "763", + "type": "gene", + "text": "The CT characteristics are discussed and the recent literature is reviewed .", + "entities": [] + }, + { + "id": "764", + "type": "gene", + "text": "A multi - centre evaluation of the card indirect agglutination test for trypanosomiasis ( TrypTect CIATT ) .", + "entities": [] + }, + { + "id": "765", + "type": "gene", + "text": "Opposite effects of CYP1 are observed in aerobic , heme - sufficient cells .", + "entities": [ + "CYP1" + ] + }, + { + "id": "766", + "type": "gene", + "text": "Of these patients , 46 , 164 were placed on a waiting list for transplantation , 23 , 275 of whom received a first cadaveric transplant between 1991 and 1997 .", + "entities": [] + }, + { + "id": "767", + "type": "gene", + "text": "This fragment contained the C - terminal 47 nucleotides of leuB , encoding 3 - isopropylmalate dehydrogenase ; asd , encoding aspartate - beta - semialdehyde dehydrogenase ( Asd ) ; and orfA , whose product showed similarity to the Asd proteins from Vibrio spp .", + "entities": [ + "leuB", + "3 - isopropylmalate dehydrogenase", + "asd", + "aspartate - beta - semialdehyde dehydrogenase", + "Asd", + "Asd proteins from Vibrio spp" + ] + }, + { + "id": "768", + "type": "gene", + "text": "Upon induction of SOS , viability increased 2 - 6 - fold .", + "entities": [] + }, + { + "id": "769", + "type": "gene", + "text": "Distal tubular acidification and the threshold for proximal tubular bicarbonate reabsorption were normal , as was urine concentrating capacity .", + "entities": [] + }, + { + "id": "770", + "type": "gene", + "text": "It thus appears that MAPK functions in meiotic maturation by preventing unfertilized eggs from proceeding into parthenogenetic development .", + "entities": [ + "MAPK" + ] + }, + { + "id": "771", + "type": "gene", + "text": "Ultrasound effect on the cytochrome oxidase activity", + "entities": [ + "cytochrome oxidase" + ] + }, + { + "id": "772", + "type": "gene", + "text": "APOE - epsilon4 count predicts age when prevalence of AD increases , then declines : the Cache County Study .", + "entities": [ + "APOE" + ] + }, + { + "id": "773", + "type": "gene", + "text": "We have isolated a cDNA encoding human MEKK3 .", + "entities": [ + "human MEKK3" + ] + }, + { + "id": "774", + "type": "gene", + "text": "Oculus - 500 is a group of high resolution imaging boards for use with IBM - AT and compatible computers .", + "entities": [] + }, + { + "id": "775", + "type": "gene", + "text": "The diet of migrants showed both positive ( macronutrients ) and negative ( micronutrients ) differences with the general Dutch diet .", + "entities": [] + }, + { + "id": "776", + "type": "gene", + "text": "We have cloned the single - copy gene for the trans - spliceosomal U5 snRNA from the trypanosomatid species Leptomonas seymouri , using U5 RNA affinity selection and cDNA cloning .", + "entities": [ + "trans - spliceosomal U5 snRNA", + "U5 RNA" + ] + }, + { + "id": "777", + "type": "gene", + "text": "In addition , both the exon 1 - and exon 2 - initiated forms of the c - Myc protein stimulated transcription of a Myc / Max - responsive reporter construct to a similar level .", + "entities": [ + "c - Myc protein", + "Myc", + "Max" + ] + }, + { + "id": "778", + "type": "gene", + "text": "Proposals on authorization ; by a group of nurses from psychiatric hospitals", + "entities": [] + }, + { + "id": "779", + "type": "gene", + "text": "To achieve complete dissection of the anterior vitreous , we remove even a clear lens during the first surgical intervention in selected cases .", + "entities": [] + }, + { + "id": "780", + "type": "gene", + "text": "These genetic alterations do not affect synthesis of the major c - myc protein , p64 , which is initiated from the first AUG codon in exon 2 .", + "entities": [ + "c - myc protein", + "p64" + ] + }, + { + "id": "781", + "type": "gene", + "text": "IV . combined sclerosis and resorption of the skull base ( 6 cases , 2 group I lesions and 4 group II lesions ) .", + "entities": [] + }, + { + "id": "782", + "type": "gene", + "text": "The Ogg1 protein efficiently cleaves a DNA duplex where a preformed AP site is placed opposite a cytosine ( AP / C ) .", + "entities": [ + "Ogg1 protein", + "AP site" + ] + }, + { + "id": "783", + "type": "gene", + "text": "Lauciello describes a technique for the placement of functionally generated amalgam stops as restorations within mandibular acrylic teeth .", + "entities": [] + }, + { + "id": "784", + "type": "gene", + "text": "Fibrinogen determination using the KZM - 1 meter", + "entities": [ + "Fibrinogen" + ] + }, + { + "id": "785", + "type": "gene", + "text": "Mutations truncating as many as 143 C - terminal residues from the transcriptional activator encoded by the areA gene , mediating nitrogen metabolite repression in Aspergillus nidulans , do not significantly reduce the ability of the areA product to activate expression of most genes under areA control .", + "entities": [ + "areA gene", + "areA product", + "areA" + ] + }, + { + "id": "786", + "type": "gene", + "text": "RESULTS : We identified a full - length cDNA with an open reading frame of 2883 bp corresponding to a predicted protein of 961 amino acids that shares greater than 95 % homology with the rat gamma - aminobutyric acid B ( GABAB ) receptor .", + "entities": [ + "rat gamma - aminobutyric acid B ( GABAB ) receptor" + ] + }, + { + "id": "787", + "type": "gene", + "text": "Because the hcf109 locus was mapped at a distance < 0 . 1 centimorgans from the phytochrome C gene , its molecular characterization by positional cloning is possible .", + "entities": [ + "hcf109 locus", + "phytochrome C gene" + ] + }, + { + "id": "788", + "type": "gene", + "text": "As a result , the subendocardial / subepicardial blood flow ratio ( ENDO / EPI ) increased from 0 . 44 + / - 0 . 09 during control stenosis to 0 . 85 + / - 0 . 13 after ITF 1129 ( 10 micrograms / kg / min i . v . ) and to 0 . 81 + / - 0 . 12 after NTG .", + "entities": [] + }, + { + "id": "789", + "type": "gene", + "text": "Analyses of hGMR beta subunit mutants revealed two cytoplasmic regions involved in activation of the c - myc promoter , one is essential and the other is dispensable but enhances the activity .", + "entities": [ + "hGMR beta subunit mutants", + "c - myc promoter" + ] + }, + { + "id": "790", + "type": "gene", + "text": "In the former instance , in addition to serum calcium and phosphorous ion concentrations , tissue pH , blood supply , hormones , i . e . , vitamin D , vitamin A , and various enzymes ( e . g . , alkaline phosphatase and pyrophosphatase ) may all play significant , ancillary , time - dependent , but as yet undetermined roles .", + "entities": [ + "alkaline phosphatase", + "pyrophosphatase" + ] + }, + { + "id": "791", + "type": "gene", + "text": "Urinary N - acetylglucosaminidase activity per mg creatinine did not differ significantly between groups .", + "entities": [ + "Urinary N - acetylglucosaminidase" + ] + }, + { + "id": "792", + "type": "gene", + "text": "The only predictor of response to tacrolimus was a previous response to cyclosporin and prednisone , either as a complete or partial remission ( remission rate 75 % vs 15 . 3 ; P = 0 . 036 ) .", + "entities": [] + }, + { + "id": "793", + "type": "gene", + "text": "In similar transient transfection experiments in HeLa cells , overexpression of the wt human retinoblastoma susceptibility gene product , RB , was found to repress the serum - induced IL - 6 ( - 225 to + 13 ) , c - fos ( - 711 to + 42 ) , and beta - actin ( - 3400 to + 912 ) promoters but not the PRV - induced IL - 6 ( - 110 to + 13 ) or the serum - induced MHC ( - 528 to - 38 ) promoters .", + "entities": [ + "wt human retinoblastoma susceptibility gene product", + "RB", + "IL - 6", + "c - fos", + "beta - actin", + "IL - 6", + "MHC" + ] + }, + { + "id": "794", + "type": "gene", + "text": "Immunoglobulin light chain ( IgL ) diversity is generated in the chicken by recombination between the single functional variable ( VL ) and joining ( JL ) gene segments and subsequent somatic diversification of the rearranged VL region .", + "entities": [ + "Immunoglobulin light chain", + "IgL", + "VL", + "JL", + "VL" + ] + }, + { + "id": "795", + "type": "gene", + "text": "Thus , replication fork movement near HML pauses at a silent origin which is competent for replication initiation but kept silent through Orc2p , a component of the replication initiator .", + "entities": [ + "HML", + "Orc2p" + ] + }, + { + "id": "796", + "type": "gene", + "text": "Hoeben , F . J .", + "entities": [] + }, + { + "id": "797", + "type": "gene", + "text": "The major PKC beta transcription initiation site was identified by primer extension and S1 nuclease protection .", + "entities": [ + "PKC beta", + "S1 nuclease" + ] + }, + { + "id": "798", + "type": "gene", + "text": "Taurine deficiency significantly depressed the amplitude of OP1 and OP4 .", + "entities": [] + }, + { + "id": "799", + "type": "gene", + "text": "Fluorescence in situ hybridization of metaphase spreads of chromosome 8 , containing hybrid cell line 706 - B6 clone 17 ( CL - 17 ) with cosmid c101F1 , placed the 9804 gene close to the telomere at 8q24 . 3 .", + "entities": [ + "9804 gene" + ] + }, + { + "id": "800", + "type": "gene", + "text": "Erythrocyte AA in FO + EPO - supplemented infants remained low and below breast - and placebo formula - fed levels .", + "entities": [ + "EPO" + ] + }, + { + "id": "801", + "type": "gene", + "text": "A preoperative teaching booklet for pediatric patients .", + "entities": [] + }, + { + "id": "802", + "type": "gene", + "text": "Endorphins and legal issues .", + "entities": [ + "Endorphins" + ] + }, + { + "id": "803", + "type": "gene", + "text": "The mean total white cell count increased from a baseline of 11 . 3 x 10 ( 9 ) / L ( SD 2 . 3 ) to 16 . 2 x 10 ( 9 ) / L ( SD 4 . 6 ) on day 1 , normalising thereafter .", + "entities": [] + }, + { + "id": "804", + "type": "gene", + "text": "Conversely , activation of this signaling pathway by expression of a constitutively active MKK1 mutant dramatically increased cyclin D1 promoter activity and cyclin D1 protein expression , in a growth factor - independent manner .", + "entities": [ + "MKK1 mutant", + "cyclin D1", + "cyclin D1 protein" + ] + }, + { + "id": "805", + "type": "gene", + "text": "Using bovine and murine c - myb clones , no change in the rate of c - myb gene transcription or mRNA stability was detected during the cell cycle .", + "entities": [ + "bovine and murine c - myb", + "c - myb gene" + ] + }, + { + "id": "806", + "type": "gene", + "text": "Epigenetic switching of transcriptional states : cis - and trans - acting factors affecting establishment of silencing at the HMR locus in Saccharomyces cerevisiae .", + "entities": [ + "HMR locus" + ] + }, + { + "id": "807", + "type": "gene", + "text": "Dissipation of claudication pain after walking : implications for endurance training .", + "entities": [] + }, + { + "id": "808", + "type": "gene", + "text": "Stability of pyrimethamine in a liquid dosage formulation stored for three months .", + "entities": [] + }, + { + "id": "809", + "type": "gene", + "text": "A 32P - labeled LAP DNA - binding and dimerization domain \" zipper probe \" was used to isolate a clone that encodes a new C / EBP - homologous protein : CHOP - 10 .", + "entities": [ + "LAP", + "C / EBP - homologous protein", + "CHOP - 10" + ] + }, + { + "id": "810", + "type": "gene", + "text": "Introduction of v - fms into a CSF - 1 dependent murine macrophage cell line induced factor independence and tumorigenicity by a nonautocrine mechanism .", + "entities": [ + "v - fms", + "CSF - 1" + ] + }, + { + "id": "811", + "type": "gene", + "text": "MotA also binds a DNA sequence ( a MotA box ) , centered at position - 30 .", + "entities": [ + "MotA", + "MotA box" + ] + }, + { + "id": "812", + "type": "gene", + "text": "This machinery involves a secondary structure , SECIS element , in the selenoprotein - encoding mRNA , directing selenocysteine insertion at the position of an opal ( UGA ) codon , normally conferring termination of translation .", + "entities": [ + "selenoprotein" + ] + }, + { + "id": "813", + "type": "gene", + "text": "The spectrum of histologically diagnosed malignant neoplasms in Sabah , 1983 - 1988 .", + "entities": [] + }, + { + "id": "814", + "type": "gene", + "text": "These studies point to the involvement of the MAP kinase pathway in the activation of monocytic cells during transmigration to inflammatory sites .", + "entities": [ + "MAP kinase" + ] + }, + { + "id": "815", + "type": "gene", + "text": "Using a series of mutant proteins , we have characterized domains responsible for activation or repression .", + "entities": [] + }, + { + "id": "816", + "type": "gene", + "text": "The data provide strong evidence that ThlA is involved in the metabolism of both acid and solvent formation , whereas the physiological function of ThlB has yet to be elucidated .", + "entities": [ + "ThlA", + "ThlB" + ] + }, + { + "id": "817", + "type": "gene", + "text": "Coactivation of endogenous or exogenous G ( q ) - coupled receptors with the delta - opioid receptor produced strong stimulations of PLCbeta and such responses could be partially blocked by pertussis toxin .", + "entities": [ + "G ( q ) - coupled receptors", + "delta - opioid receptor", + "PLCbeta", + "pertussis toxin" + ] + }, + { + "id": "818", + "type": "gene", + "text": "Biochemical experiments have shown that CopG co - operatively associates to its target DNA at low protein : DNA ratios , completely protecting four helical turns on the same face of the double helix in both directions from the inverted repeat that constitutes the CopG primary target .", + "entities": [ + "CopG", + "CopG" + ] + }, + { + "id": "819", + "type": "gene", + "text": "CONCLUSIONS : Use of the first method was associated with a reduction in the time patients remained in the ICU before transfer to another unit and savings in nursing time , but the two methods did not differ according to clinical outcomes .", + "entities": [] + }, + { + "id": "820", + "type": "gene", + "text": "Epstein - Barr virus nuclear protein 2 ( EBNA2 ) binds to a component of the human SNF - SWI complex , hSNF5 / Ini1 .", + "entities": [ + "Epstein - Barr virus nuclear protein 2", + "EBNA2", + "SNF", + "SWI", + "hSNF5", + "Ini1" + ] + }, + { + "id": "821", + "type": "gene", + "text": "The factor structure of \" schizotypal ' traits : a large replication study .", + "entities": [] + }, + { + "id": "822", + "type": "gene", + "text": "The quantitative determination of HBSAG - - a valuable aid in evaluating the infectiousness of hepatitis B virus carriers", + "entities": [ + "HBSAG" + ] + }, + { + "id": "823", + "type": "gene", + "text": "Gene constructs possessing the complete tat , rev ( tat + rev + ) and env genes were transiently expressed in COS - 1 cells as precursor SU - TM ( gp160 ) , SU . TM ( gp120 x 41 ) , and nucleolar rev protein .", + "entities": [ + "complete tat", + "rev", + "rev +", + "env genes", + "precursor SU - TM", + "gp160", + "SU . TM", + "gp120 x 41", + "nucleolar rev protein" + ] + }, + { + "id": "824", + "type": "gene", + "text": "Vascular endothelial cells undergo profound changes upon cellular activation including expression of a spectrum of cell activation - associated genes .", + "entities": [] + }, + { + "id": "825", + "type": "gene", + "text": "In a series of patients with neuroinfection , Lyme disease , Guillain Barre syndrome , demyelinization , partial or generalized , epilepsy , we have investigated antiphospholipid antibodies of IgG and IgM subtypes , together with anticoagulant factors , member of thrombocytes , sedimentation rate of erythrocytes .", + "entities": [ + "IgG", + "IgM" + ] + }, + { + "id": "826", + "type": "gene", + "text": "Sex selection via albumin columns : 20 years of results .", + "entities": [ + "albumin" + ] + }, + { + "id": "827", + "type": "gene", + "text": "Extramedullary relapse in childhood leukemia .", + "entities": [] + }, + { + "id": "828", + "type": "gene", + "text": "From S3 ( CBF : 79 - 60 % ) to S5 ( CBF : 39 - 0 % ) , % WTh , 1 / TPC and 1 / T were significantly decreased from those of the control levels ( all p less than 0 . 01 ) .", + "entities": [] + }, + { + "id": "829", + "type": "gene", + "text": "The authors evaluated the potential for thrombotic complications arising from implantation of a ventricular assist device ( Sarns / 3M - VAD ) in four calves .", + "entities": [] + }, + { + "id": "830", + "type": "gene", + "text": "Comparison of Tc - 99m sestamibi perfusion imaging and echocardiography using an arbutamine infusion for the detection of coronary artery disease .", + "entities": [] + }, + { + "id": "831", + "type": "gene", + "text": "The diagnosis of miliary tuberculosis should be systematically considered in ARDS of unknown origin .", + "entities": [] + }, + { + "id": "832", + "type": "gene", + "text": "We present here a detailed genomic sequencing analysis of the cytosine methylation patterns of the transposase binding sites within both Ac ends in the wx - m9 : : Ac allele , where Ac is inserted into the tenth exon of the Waxy gene .", + "entities": [ + "transposase", + "Ac", + "wx - m9", + "Ac allele", + "Ac", + "Waxy gene" + ] + }, + { + "id": "833", + "type": "gene", + "text": "Auto - and isotopy of the conjunctiva", + "entities": [] + }, + { + "id": "834", + "type": "gene", + "text": "All 62 isolates were resistant to lincomycin , colistin , nystatin , amphotericin B , trimethoprim lactate , polymyxin B , and anisomycin .", + "entities": [] + }, + { + "id": "835", + "type": "gene", + "text": "Takahashi , H .", + "entities": [] + }, + { + "id": "836", + "type": "gene", + "text": "Carbohydrate metabolism and the semen profile : glucose , insulin , and sperm studies .", + "entities": [ + "insulin" + ] + }, + { + "id": "837", + "type": "gene", + "text": "Risk factors associated with a high seroprevalence of hepatitis C virus infection in Egyptian blood donors .", + "entities": [] + }, + { + "id": "838", + "type": "gene", + "text": "The data obtained up to now only suggest the future potentiality of Bestatin treatment for these types of malignancy .", + "entities": [] + }, + { + "id": "839", + "type": "gene", + "text": "No difference in percentage of males in semen production was noted between strains , CP levels , or feeding regimens .", + "entities": [] + }, + { + "id": "840", + "type": "gene", + "text": "The percentages of recovery decreased with storage time , although the addition of dispersant ( Tris - Tween 80 ) before storage appeared to partially prevent adhesion .", + "entities": [] + }, + { + "id": "841", + "type": "gene", + "text": "Interplane coupling in the superconductor Y2Ba4Cu7O15 as revealed by NQR spin - echo double resonance .", + "entities": [] + }, + { + "id": "842", + "type": "gene", + "text": "OND 8 mg tid days 2 - 3 , and 8 mg tid prn days 4 - 5 and prednisolone 75 - 100 mg qds days 2 - 5 and 2 ) MCP 30 mg / metylprednisolone 80 mg i . v . before CT and MCP 20 mg p . r . after 4 and 8 h respectively .", + "entities": [] + }, + { + "id": "843", + "type": "gene", + "text": "Here we demonstrate that the Ras - activated Raf - MEK - extracellular signal - regulated kinase ( ERK ) signaling pathway can specifically control the expression of individual integrin subunits in a variety of human and mouse cell lines .", + "entities": [ + "Ras", + "Raf", + "MEK", + "extracellular signal - regulated kinase", + "ERK", + "integrin subunits" + ] + }, + { + "id": "844", + "type": "gene", + "text": "Plasma renin activity did not change in response to head - up tilt or isoprenaline infusion in the patients .", + "entities": [ + "renin" + ] + }, + { + "id": "845", + "type": "gene", + "text": "The collection of mutants displaying TGN sorting defects includes members with mutations in previously identified vacuolar protein sorting genes ( VPS ) , including the dynamin family member VPS1 .", + "entities": [ + "vacuolar protein sorting genes", + "VPS", + "dynamin", + "VPS1" + ] + }, + { + "id": "846", + "type": "gene", + "text": "In whole sardine , domoic acid was detected in levels exceeding sometimes the regulatory limit .", + "entities": [] + }, + { + "id": "847", + "type": "gene", + "text": "Human immunodeficiency virus type 1 ( HIV - 1 ) IN , expressed in Escherichia coli , was purified to near homogeneity .", + "entities": [ + "Human immunodeficiency virus type 1 ( HIV - 1 ) IN" + ] + }, + { + "id": "848", + "type": "gene", + "text": "Mouse Impact is a paternally expressed gene encoding an evolutionarily conserved protein of unknown function .", + "entities": [ + "Mouse Impact" + ] + }, + { + "id": "849", + "type": "gene", + "text": "Effect of separate and combined effects of plutonium - 239 , hexachlorobutadiene and tributyl phosphate on the thymus gland of rats", + "entities": [] + }, + { + "id": "850", + "type": "gene", + "text": "Here we report on the isolation of ICK2 , and show that it interacts with Cdc2aAt , but not with a second CDK from Arabidopsis , Cdc2bAt .", + "entities": [ + "ICK2", + "Cdc2aAt", + "CDK from Arabidopsis", + "Cdc2bAt" + ] + }, + { + "id": "851", + "type": "gene", + "text": "I hypothesize that white gene expression from P [ en ] is repressed by the formation of a protein complex which is initiated at the engrailed PS sites and also requires interactions with flanking genomic DNA .", + "entities": [ + "white gene", + "P [ en ]", + "engrailed PS sites" + ] + }, + { + "id": "852", + "type": "gene", + "text": "There was either no change or an improvement in renographic findings ( t1 / 2 time and / or split function ) in 40 patients ( 93 % ) .", + "entities": [] + }, + { + "id": "853", + "type": "gene", + "text": "nos - 1 and nos - 2 , two genes related to Drosophila nanos , regulate primordial germ cell development and survival in Caenorhabditis elegans .", + "entities": [ + "nos - 1", + "nos - 2", + "Drosophila nanos" + ] + }, + { + "id": "854", + "type": "gene", + "text": "A potential binding site for the dShc PTB domain is located at Tyr - 1228 of DER .", + "entities": [ + "dShc", + "DER" + ] + }, + { + "id": "855", + "type": "gene", + "text": "E47 protein levels remain high until the double positive developmental stage , at which point they drop to relatively moderate levels , and are further downregulated upon transition to the single positive stage .", + "entities": [ + "E47 protein" + ] + }, + { + "id": "856", + "type": "gene", + "text": "A p21 peptide spanning amino acids 139 - 164 was found to bind PCNA in a filter binding assay and this peptide suppressed recombinant p21 - PCNA interaction .", + "entities": [ + "p21 peptide", + "PCNA", + "p21", + "PCNA" + ] + }, + { + "id": "857", + "type": "gene", + "text": "The production of ceramide is emerging as a fixture of programmed cell death .", + "entities": [] + }, + { + "id": "858", + "type": "gene", + "text": "The first involved complementation of a nonphotosynthetic mutant of Chlamydomonas , CC - 2341 ( ac - u - g - 2 . 3 ) , which has a frameshift mutation in the psaB gene , and selection of photosynthetic transformants on minimal medium .", + "entities": [ + "psaB gene" + ] + }, + { + "id": "859", + "type": "gene", + "text": "It acts on Cdks in the G1 and S phases of the cell cycle , and also binds to proliferating cell nuclear antigen ( PCNA ) , blocking DNA replication in vitro .", + "entities": [ + "Cdks", + "proliferating cell nuclear antigen", + "PCNA" + ] + }, + { + "id": "860", + "type": "gene", + "text": "Two patients withdrew from therapy , one for personal reasons and one because a paraspinal mass developed .", + "entities": [] + }, + { + "id": "861", + "type": "gene", + "text": "This dimer interface is likely important for increasing the DNA - binding specificity and affinity of the trimeric form of HSF , as well as for increasing cooperativity between adjacent trimers .", + "entities": [ + "HSF" + ] + }, + { + "id": "862", + "type": "gene", + "text": "Characterisation of the chicken apolipoprotein A - I gene 5 ' - flanking region .", + "entities": [ + "chicken apolipoprotein A - I gene" + ] + }, + { + "id": "863", + "type": "gene", + "text": "With histology and Evans blue injections , blood - brain barrier alterations were seen as early as 4 days after a dose of 50 Gy .", + "entities": [] + }, + { + "id": "864", + "type": "gene", + "text": "From our ultrastructural and biochemical studies , it is evident that Type II pneumocytes are an early target of radiation and the release of surfactant into the alveolus shortly after exposure persists for days and weeks .", + "entities": [] + }, + { + "id": "865", + "type": "gene", + "text": "A . , Bowers , K . E , and Matthews , C .", + "entities": [] + }, + { + "id": "866", + "type": "gene", + "text": "Preferential heterodimeric parallel coiled - coil formation by synthetic Max and c - Myc leucine zippers : a description of putative electrostatic interactions responsible for the specificity of heterodimerization .", + "entities": [ + "synthetic Max", + "c - Myc leucine zippers" + ] + }, + { + "id": "867", + "type": "gene", + "text": "The mutation within the asgB480 allele was identified as an A - to - G transition that results in a threonine - to - alanine substitution in the predicted protein product .", + "entities": [ + "asgB480 allele" + ] + }, + { + "id": "868", + "type": "gene", + "text": "No previous studies have determined the pharmaco - dynamics of intravenous procainamide when administered in a dose of 15 mg / kg and at a rate of 50 mg / min , as is common practice during electropharmacologic testing .", + "entities": [] + }, + { + "id": "869", + "type": "gene", + "text": "The main causes of liver disease in the patients with HCC were hepatitis C virus ( HCV ) ( 77 % ) , alcohol abuse ( 73 % ) , and the combination of HCV and alcohol abuse ( 50 % ) .", + "entities": [] + }, + { + "id": "870", + "type": "gene", + "text": "GCR1 gene function is required for high - level glycolytic gene expression in Saccharomyces cerevisiae .", + "entities": [ + "GCR1 gene" + ] + }, + { + "id": "871", + "type": "gene", + "text": "The UV induction of c - jun is mediated by two UV response elements consisting of AP - 1 - like sequences within its 5 ' control region .", + "entities": [ + "c - jun", + "AP - 1 - like sequences" + ] + }, + { + "id": "872", + "type": "gene", + "text": "Induction of proto - oncogene fos transcription through the adenylate cyclase pathway : characterization of a cAMP - responsive element .", + "entities": [ + "proto - oncogene fos", + "adenylate cyclase" + ] + }, + { + "id": "873", + "type": "gene", + "text": "This result suggested that mutant I299 has diminished cap - binding activity .", + "entities": [] + }, + { + "id": "874", + "type": "gene", + "text": "This gene encodes a putative transcription factor with regions of homology to several other proteins including the zinc fingers and other domains of the Drosophila trithorax gene product , and the \" AT - hook \" DNA - binding motif of high mobility group proteins .", + "entities": [ + "Drosophila trithorax gene product", + "high mobility group proteins" + ] + }, + { + "id": "875", + "type": "gene", + "text": "Trial treatment of schizophrenia with des - Tyr - gamma - endorphin", + "entities": [] + }, + { + "id": "876", + "type": "gene", + "text": "Instead , some small negative effects are observed , particularly involving effects of husbands ' retirement on the marital satisfaction of employed wives .", + "entities": [] + }, + { + "id": "877", + "type": "gene", + "text": "Deletion or inactivation of CRY1 leads to 5 - to 10 - fold - increased levels of CRY2 mRNA .", + "entities": [ + "CRY1", + "CRY2 mRNA" + ] + }, + { + "id": "878", + "type": "gene", + "text": "To examine the possibility that LNNB performance of the schizophrenic groups may have been related to neuroleptic medication , analyses were completed on the relationship between medication levels and LNNB scores .", + "entities": [] + }, + { + "id": "879", + "type": "gene", + "text": "Guiding patients in the decision should involve a multidisciplinary team composed of a surgical oncologist , geneticist , pathologist , psychotherapist and plastic surgeon .", + "entities": [] + }, + { + "id": "880", + "type": "gene", + "text": "Each patient had measurable LH and FSH levels , with pulsed nocturnal secretion , and pubertal LH and FSH responses to LRH .", + "entities": [ + "LH", + "FSH", + "LH", + "FSH", + "LRH" + ] + }, + { + "id": "881", + "type": "gene", + "text": "A bacteriological relapse requiring treatment occurred by 5 years in 16 . 8 % of 113 R3 , 5 . 2 % of 97 R5 , and 20 . 0 % of 115 Z5 patients with organisms sensitive to streptomycin and isoniazid initially .", + "entities": [] + }, + { + "id": "882", + "type": "gene", + "text": "2 : The dynamic moduli of microcrystalline cellulose .", + "entities": [] + }, + { + "id": "883", + "type": "gene", + "text": "Sensory evoked field potentials were recorded from the mesencephalic reticular formation ( MRF ) , central gray ( CG ) and somatosensory cortex ( SCX ) , following incremental doses of halothane in freely - moving rats .", + "entities": [] + }, + { + "id": "884", + "type": "gene", + "text": "The results of supershift analysis using specific antibodies against transcription factors suggested that both binding complexes contained the NF - kappaB components p50 and p65 , and did not contain other NF - kappaB proteins ( p52 , c - Rel , Rel B ) , AP - 1 proteins ( c - Fos , C - Jun ) , CREB or C / EBPbeta ( NF - IL6 ) .", + "entities": [ + "NF - kappaB", + "p50", + "p65", + "NF - kappaB proteins", + "p52", + "c - Rel", + "Rel B", + "AP - 1 proteins", + "c - Fos", + "C - Jun", + "CREB", + "C / EBPbeta", + "NF - IL6" + ] + }, + { + "id": "885", + "type": "gene", + "text": "Angiotensin effect in the human kidney .", + "entities": [ + "Angiotensin" + ] + }, + { + "id": "886", + "type": "gene", + "text": "The Saccharomyces cerevisiae GAL1 and GAL10 genes are controlled in response to the availability of galactose and glucose by multiple activating and repressing proteins bound at adjacent or overlapping sites in UASG .", + "entities": [ + "Saccharomyces cerevisiae GAL1", + "GAL10 genes" + ] + }, + { + "id": "887", + "type": "gene", + "text": "Expression of GlcNAc - TI mRNA in tobacco leaves was detected using RT - PCR .", + "entities": [ + "GlcNAc - TI mRNA" + ] + }, + { + "id": "888", + "type": "gene", + "text": "These changes correlate directly with an increase in the acetylation levels of all four core histones in vivo .", + "entities": [ + "core histones" + ] + }, + { + "id": "889", + "type": "gene", + "text": "Such an interaction could be detected using a GST - POU fusion protein bound to glutathione - agarose beads .", + "entities": [ + "GST", + "POU" + ] + }, + { + "id": "890", + "type": "gene", + "text": "Hypomagnesemia was due to magnesium wasting by the kidney .", + "entities": [] + }, + { + "id": "891", + "type": "gene", + "text": "Regional CBF was determined by clearance of xenon 133 in 67 patients undergoing coronary bypass grafting procedures .", + "entities": [] + }, + { + "id": "892", + "type": "gene", + "text": "This multiple - electrode array for round window cochlear implantation is a robust , reliable system for inserting 20 mm along the scala tympani with a minimum of trauma and can provide for bipolar stimulation .", + "entities": [] + }, + { + "id": "893", + "type": "gene", + "text": "These studies suggest an additional component or cellular environment is required for SPRK activation by Cdc42 .", + "entities": [ + "SPRK", + "Cdc42" + ] + }, + { + "id": "894", + "type": "gene", + "text": "The corresponding genotype was determined with a restriction enzyme - based assay .", + "entities": [] + }, + { + "id": "895", + "type": "gene", + "text": "We describe a case of a perinephric abscess treated with amphotericin B and nephrectomy .", + "entities": [] + }, + { + "id": "896", + "type": "gene", + "text": "Finally , we demonstrate that C / EBP alpha can also active the GM - CSF receptor alpha promoter in nonmyeloid cells .", + "entities": [ + "C / EBP alpha", + "GM - CSF receptor alpha" + ] + }, + { + "id": "897", + "type": "gene", + "text": "Similar memory impairments found in medial septal - vertical diagonal band of Broca and nucleus basalis lesioned rats : are memory defects induced by nucleus basalis lesions related to the degree of non - specific subcortical cell loss ?", + "entities": [] + }, + { + "id": "898", + "type": "gene", + "text": "The function of nucleus basalis ( NB ) and medial septal - vertical diagonal band of Broca ( MS - VDBB ) in a place navigation task requiring reference memory was investigated .", + "entities": [] + }, + { + "id": "899", + "type": "gene", + "text": "UV cross - linking experiments demonstrated that HSV infection caused enhanced binding of protein factors , including the 64 - kDa component of cleavage stimulation factor ( CstF ) , to poly ( A ) site RNAs from virus genes of all temporal classes and that this enhanced binding required expression of IE63 .", + "entities": [ + "64 - kDa component of cleavage stimulation factor", + "CstF", + "IE63" + ] + }, + { + "id": "900", + "type": "gene", + "text": "As for 31 stage I - II lung cancer patients , CR has been observed in 82 . 8 % of them and PR in 13 . 8 % ; the response was always assessed with chest radiography , CT , FBS , cytology and / or histology .", + "entities": [] + }, + { + "id": "901", + "type": "gene", + "text": "Our purpose was to determine if intact perianal ( S4 - 5 ) pin sensation ( PPS ) and bulbocavernosus ( S2 - 4 ) reflex ( BCR ) shortly after spinal cord injury ( SCI ) are predictive of bladder function recovery .", + "entities": [] + }, + { + "id": "902", + "type": "gene", + "text": "The transcription factor Sp1 bound to eight sites , as demonstrated by footprinting assays and gel shift analysis with purified Sp1 .", + "entities": [ + "Sp1", + "Sp1" + ] + }, + { + "id": "903", + "type": "gene", + "text": "The P69 cell line was derived by immortalization of human primary prostate epithelial cells with simian virus - 40 T antigen and is rarely tumorigenic .", + "entities": [ + "simian virus - 40 T antigen" + ] + }, + { + "id": "904", + "type": "gene", + "text": "The inhibitory response to taps is essentially a protective reflex which probably serves to reduce the activity of the jaw - closing muscles when one bites unexpectedly on hard objects .", + "entities": [] + }, + { + "id": "905", + "type": "gene", + "text": "No effect of the intervention on depression scores was found .", + "entities": [] + }, + { + "id": "906", + "type": "gene", + "text": "The defect in these proteins was also uniformly suppressed by either Mn2 + , or the Mu B protein in the presence of ATP and target DNA .", + "entities": [ + "Mu B protein" + ] + }, + { + "id": "907", + "type": "gene", + "text": "The responses of the \" stress hormones \" cortisol , 11 - deoxycortisol , ACTH , vasopressin ( AVP ) , and corticotropin releasing factor ( CRF ) were studied in 6 normal males in response to acute cortisol deficiency induced by the 11 - beta - hydroxylase inhibitor , metyrapone .", + "entities": [ + "ACTH", + "vasopressin", + "AVP", + "corticotropin releasing factor", + "CRF", + "11 - beta - hydroxylase" + ] + }, + { + "id": "908", + "type": "gene", + "text": "Further research is recommended to identify the coping styles associated with the high EE / low EE research classification .", + "entities": [] + }, + { + "id": "909", + "type": "gene", + "text": "Gentamicin given by DPI and SVN significantly decreased the sputum Psa density ( p < 0 . 05 ) , by almost one order of magnitude .", + "entities": [] + }, + { + "id": "910", + "type": "gene", + "text": "Effect of 2 - ( p - chlorophenyl ) cyclopropylamine on 5 - hydroxyindole concentration and monoamine oxidase activity in rat brain .", + "entities": [ + "monoamine oxidase" + ] + }, + { + "id": "911", + "type": "gene", + "text": "Owing to parental attitude , a low protein diet ( 1 - 5 g / kg ) was introduced only late .", + "entities": [] + }, + { + "id": "912", + "type": "gene", + "text": "Of 115 hepatitis B patients seen at 12 months , 6 % had chronic hepatitis Bs antigenaemia , 60 % had developed anti - HBs antibodies , and 7 . 3 % still had abnormal liver function .", + "entities": [ + "anti - HBs antibodies" + ] + }, + { + "id": "913", + "type": "gene", + "text": "The regulatory region also has a sequence similar to the binding site for a liver - specific transcription factor , hepatocyte nuclear factor 1 ( HNF - 1 ) , at positions - 120 to - 132 .", + "entities": [ + "hepatocyte nuclear factor 1", + "HNF - 1" + ] + }, + { + "id": "914", + "type": "gene", + "text": "In addition , the utility of beta 2 transferrin assay in the diagnosis of cerebrospinal fluid otorrhea is presented .", + "entities": [ + "beta 2 transferrin" + ] + }, + { + "id": "915", + "type": "gene", + "text": "Fourteen patients with New York Heart Association class II congestive heart failure were enrolled in a double - blind , cross - over study .", + "entities": [] + }, + { + "id": "916", + "type": "gene", + "text": "The retinoid Z receptor beta ( RZR beta ) , an orphan receptor , is a member of the retinoic acid receptor ( RAR ) / thyroid hormone receptor ( TR ) subfamily of nuclear receptors .", + "entities": [ + "retinoid Z receptor beta", + "RZR beta", + "retinoic acid receptor", + "RAR", + "thyroid hormone receptor", + "TR" + ] + }, + { + "id": "917", + "type": "gene", + "text": "In the IA task , post - training intraperitoneal injections of picrotoxin and bicuculline induced a dose - dependent enhancement of retention measured 24 h after the training , while retention was not affected by bicuculline methiodide ( a GABA receptor antagonist that does not readily cross the blood - brain barrier ) .", + "entities": [ + "GABA receptor" + ] + }, + { + "id": "918", + "type": "gene", + "text": "METHODS : The passive and active transport of fluorescein through the BRB was quantitated by vitreous fluorometry .", + "entities": [] + }, + { + "id": "919", + "type": "gene", + "text": "2000 update of recommendations for the use of hematopoietic colony - stimulating factors : evidence - based , clinical practice guidelines .", + "entities": [ + "hematopoietic colony - stimulating factors" + ] + }, + { + "id": "920", + "type": "gene", + "text": "Gamma glutamyl transpeptidase activity was increased up to 15 times above the upper normal limit in children , who received aminopyrine for two weeks or longer .", + "entities": [ + "Gamma glutamyl transpeptidase" + ] + }, + { + "id": "921", + "type": "gene", + "text": "Another sequence , GGGXGGAG , which is repeated several times in many polyomaviruses and adenoviruses , and which is thought to play a role in DNA replication and / or transcription , is not found in the JCV sequence presented .", + "entities": [] + }, + { + "id": "922", + "type": "gene", + "text": "A stable heterologous cell line containing the mouse TRH receptor was constructed by transfection of nonexcitable 293 cells , which lack L channel activity .", + "entities": [ + "mouse TRH receptor" + ] + }, + { + "id": "923", + "type": "gene", + "text": "Two classes of Xanthomonas pathogens evading Bs2 host resistance and displaying reduced fitness were found to be specifically mutated in avrBs2 .", + "entities": [ + "avrBs2" + ] + }, + { + "id": "924", + "type": "gene", + "text": "Most eukaryotic mRNAs are translated by a \" scanning ribosome \" mechanism .", + "entities": [] + }, + { + "id": "925", + "type": "gene", + "text": "It is suggested that the use of endogenous creatinine clearance to estimate the glomerular filtration rate ( GFR ) requires caution and the recognition of the limitations of the method , and that simpler techniques ( serum creatinine or estimated endogenous creatinine clearance ) are preferable in routine practice .", + "entities": [] + }, + { + "id": "926", + "type": "gene", + "text": "All six ARF cDNAs are more similar to each other than to other approximately 20 - kDa guanine nucleotide - binding proteins .", + "entities": [ + "ARF cDNAs", + "20 - kDa guanine nucleotide - binding proteins" + ] + }, + { + "id": "927", + "type": "gene", + "text": "Overall , these findings demonstrate that mutations E768D and V804L are gain - of - function mutations that confer to the long RET isoform the capacity to exert a biological effect , although these mutations are more weakly activating than the MEN2A and MEN2B mutations .", + "entities": [ + "long RET isoform", + "MEN2A", + "MEN2B" + ] + }, + { + "id": "928", + "type": "gene", + "text": "More generally , Ets1 and Ets2 could regulate transcription of cellular genes .", + "entities": [ + "Ets1", + "Ets2" + ] + }, + { + "id": "929", + "type": "gene", + "text": "Sequencing of a 1 . 3 - kilobase fragment of the 5 ' - flanking region of the TSG6 gene identified TATA - like and CAAT sequences near the transcription start site .", + "entities": [ + "TSG6 gene" + ] + }, + { + "id": "930", + "type": "gene", + "text": "Homozygous mutation in two children led to amputation of legs due to purpura fulminans .", + "entities": [] + }, + { + "id": "931", + "type": "gene", + "text": "Ecthyma , a known disease , of which little is known", + "entities": [] + }, + { + "id": "932", + "type": "gene", + "text": "In order to provide adequate local control without compromising cosmetic outcome , the amount of breast tissue that must be excised in BCT needs to be individualized .", + "entities": [] + }, + { + "id": "933", + "type": "gene", + "text": "Genetic abnormalities that could lead to mutagenesis include chromosomal abnormalities and single - gene mutations .", + "entities": [] + }, + { + "id": "934", + "type": "gene", + "text": "These intron chimeras show that peripheral sequences and the elements that define the splice sites are adequate for self - splicing activity but that the central portions containing the catalytic cores of ai4 and bi4 are deficient ; these cores are the likely targets of the splicing proteins .", + "entities": [ + "ai4", + "bi4" + ] + }, + { + "id": "935", + "type": "gene", + "text": "Following the observation that non - organ - specific antibodies are related with pregnancy loss and preeclampsia , the role of organ - specific antibodies is currently being extensively investigated .", + "entities": [] + }, + { + "id": "936", + "type": "gene", + "text": "We propose that the reduced responsiveness of CYP3A2 is the result of preferential binding of COUP - TF at the CYP3A2 DexRE - 1 site .", + "entities": [ + "CYP3A2", + "COUP - TF", + "CYP3A2 DexRE - 1 site" + ] + }, + { + "id": "937", + "type": "gene", + "text": "In a stepwise logistic regression analysis of SPT and RAST data , the occurrence of serum IgE antibodies to P . orbiculare had the highest explanatory value for current eczema .", + "entities": [ + "serum IgE antibodies to P . orbiculare" + ] + }, + { + "id": "938", + "type": "gene", + "text": "NF - kappaB is a redox - sensitive transcription factor known to be activated by oxidative stress as well as chemical and biological reductants .", + "entities": [ + "NF - kappaB" + ] + }, + { + "id": "939", + "type": "gene", + "text": "The recombinant enzymes exist as monomers .", + "entities": [] + }, + { + "id": "940", + "type": "gene", + "text": "Renal and extrarenal arterial fibromuscular hyperplasia with hypertension .", + "entities": [] + }, + { + "id": "941", + "type": "gene", + "text": "Animal studies showed that beam equalization significantly improved fluoroscopic and angiographic image quality .", + "entities": [] + }, + { + "id": "942", + "type": "gene", + "text": "Southwestern blot analysis demonstrated that this phosphoprotein can bind the kappa B element directly and specifically .", + "entities": [ + "kappa B element" + ] + }, + { + "id": "943", + "type": "gene", + "text": "A cohort of Swedish children was monitored from 6 months to 11 years of age .", + "entities": [] + }, + { + "id": "944", + "type": "gene", + "text": "The congenital forms ( 7 cases ) all occurred in female infants and involved the mucosa overlying either the anterior ridge of the maxilla or the mandible .", + "entities": [] + }, + { + "id": "945", + "type": "gene", + "text": "Although most SH2 - pTyr interactions occur between two different types of molecules , some appear to involve only a single molecular type .", + "entities": [ + "SH2", + "pTyr" + ] + }, + { + "id": "946", + "type": "gene", + "text": "Thus , sgRNA2 has the 3 ' TE in its 5 ' UTR .", + "entities": [ + "sgRNA2" + ] + }, + { + "id": "947", + "type": "gene", + "text": "Sequence conservation is greatest for residues located near the active centers of the exo and pol domains of the E . coli DNA polymerase I structure .", + "entities": [ + "exo", + "pol domains", + "E . coli DNA polymerase I" + ] + }, + { + "id": "948", + "type": "gene", + "text": "However , it is not known whether the recently identified isoforms Vav2 and Vav3 , which are broadly expressed , can couple with similar classes of receptors , nor is it known whether all Vav isoforms possess identical functional activities .", + "entities": [ + "Vav2", + "Vav3", + "Vav isoforms" + ] + }, + { + "id": "949", + "type": "gene", + "text": "On the diagnosis of bovine leucosis and its control in southern Lower Saxony", + "entities": [] + }, + { + "id": "950", + "type": "gene", + "text": "High - pressure effects on ultrafast - relaxation kinetics of excitons in polydiacetylene 4BCMU .", + "entities": [] + }, + { + "id": "951", + "type": "gene", + "text": "Effects of verapamil and propranolol on early afterdepolarizations and ventricular arrhythmias induced by epinephrine in congenital long QT syndrome .", + "entities": [] + }, + { + "id": "952", + "type": "gene", + "text": "The aim of the present study was to examine the antimicrobial susceptibility to 10 currently used antimicrobial agents of 50 strains of P . acnes isolated from acne lesions and identified using a Rap ID ANA II panel .", + "entities": [] + }, + { + "id": "953", + "type": "gene", + "text": "Mental development is generally normal .", + "entities": [] + }, + { + "id": "954", + "type": "gene", + "text": "Sequences needed for iron - regulated expression of sid1 were localized to a 306 bp region mapping 2 . 3 and 2 . 6 kb upstream of the ATG .", + "entities": [ + "sid1" + ] + }, + { + "id": "955", + "type": "gene", + "text": "The average coefficients of correlation were 0 . 9998 and 0 . 9993 for the QMF and the QIT system , respectively .", + "entities": [] + }, + { + "id": "956", + "type": "gene", + "text": "This result supports the argument that the beta ' subunit plays an essential role in determining the progress of transcription elongation .", + "entities": [] + }, + { + "id": "957", + "type": "gene", + "text": "The E1 gene is located within the first intron of the gene for RCC1 , a protein that regulates onset of mitosis .", + "entities": [ + "E1 gene", + "RCC1" + ] + }, + { + "id": "958", + "type": "gene", + "text": "The other element bound RBP - J kappa with low affinity .", + "entities": [ + "RBP - J kappa" + ] + }, + { + "id": "959", + "type": "gene", + "text": "The role of protein kinase C signaling in activated DRA transcription .", + "entities": [ + "protein kinase C", + "DRA" + ] + }, + { + "id": "960", + "type": "gene", + "text": "An open reading frame of 2862 bp encoding a 954 amino acid protein was identified .", + "entities": [] + }, + { + "id": "961", + "type": "gene", + "text": "Ten selenocysteine residues ( deduced ) are present .", + "entities": [] + }, + { + "id": "962", + "type": "gene", + "text": "100 and 14 p .", + "entities": [] + }, + { + "id": "963", + "type": "gene", + "text": "Pneumothorax during laparoscopic dissection of the diaphragmatic hiatus .", + "entities": [] + }, + { + "id": "964", + "type": "gene", + "text": "The neuroleptic - induced increase in central DA turnover ( an indicator for the degree of DA receptor blocking ) was found to be positively correlated with the therapeutic effect of neuroleptics and the development of hypokinetic - rigid symptoms .", + "entities": [ + "DA receptor" + ] + }, + { + "id": "965", + "type": "gene", + "text": "Selective stimulation of central alpha - autoreceptors following treatment with alpha - methyldopa and FLA 136 .", + "entities": [ + "alpha - autoreceptors" + ] + }, + { + "id": "966", + "type": "gene", + "text": "The effect of calcitonin , a large amount of calcium given orally , pentagastrin and glucagon on plasma 47Ca radioactivity curves in subjects pretreated with 47Ca was examined .", + "entities": [ + "calcitonin", + "glucagon" + ] + }, + { + "id": "967", + "type": "gene", + "text": "Taken together , the results suggest that chlorphentermine may be capable of producing dual stimulus effects in animals .", + "entities": [] + }, + { + "id": "968", + "type": "gene", + "text": "The malignity of nevoid lentigo .", + "entities": [] + }, + { + "id": "969", + "type": "gene", + "text": "Tetrad analysis and mitotic recombination experiments localized the PEP4 gene proximal to GAL4 on chromosome XVI .", + "entities": [ + "PEP4 gene", + "GAL4" + ] + }, + { + "id": "970", + "type": "gene", + "text": "Two Lab 8 computer programmes for use in the study of the isometric and isotonic contractile characteristics of skeletal muscle .", + "entities": [] + }, + { + "id": "971", + "type": "gene", + "text": "Pharmacokinetics of FK 506 in transplant patients .", + "entities": [] + }, + { + "id": "972", + "type": "gene", + "text": "As the length of the fatty acid decreased , the binding affinity was reduced ; myristic acid ( 14 : 0 ) bound with a K ( d ) of 1409 + / - 423 nM , but medium - chain ( decanoic acid , 10 : 0 ) and short - chain ( octanoic acid , 8 : 0 ) lipids were not bound at all .", + "entities": [] + }, + { + "id": "973", + "type": "gene", + "text": "Persistent acantholytic dermatosis with increased light sensitivity", + "entities": [] + }, + { + "id": "974", + "type": "gene", + "text": "Magnetic resonance spectroscopy ( MRS ) and imaging ( MRI ) are now well established techniques for the study of cellular metabolism and gross structure of muscle .", + "entities": [] + }, + { + "id": "975", + "type": "gene", + "text": "However , 2 minimum alveolar concentration anesthesia did significantly decrease the calculated VE at a PCO2 of 60 mmHg ( from 7 . 4 + / - 1 . 2 to 4 . 0 + / - 0 . 6 l . min - 1 ) , indicating a rightward shift in the response relationship .", + "entities": [] + }, + { + "id": "976", + "type": "gene", + "text": "One maternal death , reduced body weight , and reduced weight gain were noted at the high dose ; confirmed pregnancy rates were 84 to 100 % for each group .", + "entities": [] + }, + { + "id": "977", + "type": "gene", + "text": "Pulmonary arterial pressure and structure in the patas monkey after prolonged administration of aminorex fumarate .", + "entities": [] + }, + { + "id": "978", + "type": "gene", + "text": "Transient overexpression of mutant EphB1 receptors ( Y594F ) blocked Nck recruitment to EphB1 , attenuated downstream JNK activation , and blocked cell attachment responses .", + "entities": [ + "mutant EphB1 receptors", + "Nck", + "EphB1", + "JNK" + ] + }, + { + "id": "979", + "type": "gene", + "text": "Overexpression of the bZip interaction domain of CBP specifically abolishes the positive cross talk between TR and p45 / NF - E2 .", + "entities": [ + "CBP", + "TR", + "p45", + "NF - E2" + ] + }, + { + "id": "980", + "type": "gene", + "text": "High - frequency electrical stimulation in the hippocampus leads to an increase in synaptic efficacy that lasts for many hours .", + "entities": [] + }, + { + "id": "981", + "type": "gene", + "text": "Drug - drug interactions are most likely to occur in patients receiving multiple medications and with drugs that have a narrow therapeutic window .", + "entities": [] + }, + { + "id": "982", + "type": "gene", + "text": "In sixteen patients with moderate essential hypertension the effects of 10 - day nifedipine treatment on serum uric acid and renal excretion of uric acid were evaluated .", + "entities": [] + }, + { + "id": "983", + "type": "gene", + "text": "Ciprofloxacin : an overview of adverse experiences .", + "entities": [] + }, + { + "id": "984", + "type": "gene", + "text": "In an ongoing study the performance of the SMSP is being compared with that of the Mini Speech Processor ( MSP ) .", + "entities": [] + }, + { + "id": "985", + "type": "gene", + "text": "The second transcriptional unit , designated UL26 . 5 , predicted to specify a protein of 329 amino acids , encodes the family 35 proteins ; it is transcribed by an mRNA which initiates at approximately nucleotide + 1000 of the UL26 transcription initiation site and is translated from the methionine initiation codon located at position + 1099 of the UL26 transcriptional unit .", + "entities": [ + "UL26 . 5", + "family 35 proteins", + "UL26", + "UL26 transcriptional unit" + ] + }, + { + "id": "986", + "type": "gene", + "text": "Taken together , these results suggest that the cooperation of transcription factors NF - kappaB and AP - 1 is essential for transactivation of IL - 8 gene by HTLV - I Tax .", + "entities": [ + "transcription factors NF - kappaB", + "AP - 1", + "IL - 8 gene", + "HTLV - I Tax" + ] + }, + { + "id": "987", + "type": "gene", + "text": "Using this reporter gene system , we previously showed that EPO - induced activation of the c - fos promoter can be detected rapidly and sensitively as an elevation of cellular luciferase activity .", + "entities": [ + "EPO", + "c - fos promoter", + "cellular luciferase" + ] + }, + { + "id": "988", + "type": "gene", + "text": "The findings are discussed in the context of known properties of cortical - bar detectors .", + "entities": [] + }, + { + "id": "989", + "type": "gene", + "text": "This observation calls for careful monitoring of calcium and alkaline phosphatase values and possible adjustments of vitamin D intake when fortifiers are used for extended periods .", + "entities": [ + "alkaline phosphatase" + ] + }, + { + "id": "990", + "type": "gene", + "text": "Morphologic variables included cancer volume , histologic grade , capsular penetration , seminal vesicle invasion , and lymph node metastasis .", + "entities": [] + }, + { + "id": "991", + "type": "gene", + "text": "From Pap to ApUp .", + "entities": [] + }, + { + "id": "992", + "type": "gene", + "text": "The susceptibility of Aspergillus fumigatus to mulundocandin , an echinocandin - like compound , and other antifungal agents was assessed by the National Committee for Clinical Laboratory Standards ( NCCLS ) M38 - P method , a 2 , 3 - bis ( 2 - methoxy - 4 - nitro - 5 - sulfophenyl ) - 5 - [ ( phenyl - amino ) carbonyl ] - 2H - tetrazolium hydroxide ( XTT ) - based colorimetric assay , and determination of morphologic alterations by microscopy .", + "entities": [] + }, + { + "id": "993", + "type": "gene", + "text": "Multiple regression analyses revealed that WAIS - R factor scores Verbal Comprehension and Freedom from Distractibility accounted for up to 42 % of the variance in WMS - R and CVLT indices .", + "entities": [] + }, + { + "id": "994", + "type": "gene", + "text": "Determination of 20 alpha - hydroxy - 9 beta , 10 alpha - pregna - 4 , 6 - dien - 3 - one in plasma by selected ion monitoring .", + "entities": [] + }, + { + "id": "995", + "type": "gene", + "text": "Our study reveals that the modular structure of the FSH receptor gene generates motifs that allows coupling to different effectors .", + "entities": [ + "FSH receptor" + ] + }, + { + "id": "996", + "type": "gene", + "text": "Homo - oligomerisation and nuclear localisation of mouse histone deacetylase 1 .", + "entities": [ + "mouse histone deacetylase 1" + ] + }, + { + "id": "997", + "type": "gene", + "text": "Ariga , Biochem .", + "entities": [] + }, + { + "id": "998", + "type": "gene", + "text": "However , mechanisms underlying HIV - 1 gene expression in the CNS are poorly understood .", + "entities": [] + }, + { + "id": "999", + "type": "gene", + "text": "Different sequence elements of both the retroviral vectors and the c - myc gene recombined during genesis of highly oncogenic retroviruses CMII , MC29 , or MH2 .", + "entities": [ + "c - myc gene" + ] + }, + { + "id": "1000", + "type": "gene", + "text": "Ten weeks after reconstruction , the regenerating nerves already resembled normal nerves .", + "entities": [] + }, + { + "id": "1001", + "type": "gene", + "text": "Of these sites , PEA3 and STAT contributed specifically to induction by v - src , whereas the remaining elements were also involved in induction by the phorbol ester phorbol myristate acetate ( PMA ) .", + "entities": [ + "PEA3", + "STAT", + "v - src" + ] + }, + { + "id": "1002", + "type": "gene", + "text": "Results from transient assays using these mutants showed that the DE1 received signals from phytochromes A and B , demonstrating that this element is indeed a light - responsive element .", + "entities": [ + "phytochromes A and B" + ] + }, + { + "id": "1003", + "type": "gene", + "text": "Gel retardation assays detected ZiaR - dependent complexes forming with the zia operator - promoter and ZiaR - DNA binding was enhanced by treatment with a metal - chelator in vitro .", + "entities": [ + "ZiaR", + "zia operator - promoter", + "ZiaR" + ] + }, + { + "id": "1004", + "type": "gene", + "text": "Consistent with a possible role in transcription , Paf1p is localized to the nucleus .", + "entities": [ + "Paf1p" + ] + }, + { + "id": "1005", + "type": "gene", + "text": "Serial levels of troponin T and the activity of CK - MB were measured 6 , 12 , 24 and 48 h after aortic unclamping .", + "entities": [ + "troponin T", + "CK - MB" + ] + }, + { + "id": "1006", + "type": "gene", + "text": "The growth of Aer . hydrophila in filter - sterilized lettuce extract was completely inhibited by 0 . 1 % ( v / v ) BMC whereas that of Ps . fluorescens was not significantly affected by 1 % ( v / v ) BMC .", + "entities": [] + }, + { + "id": "1007", + "type": "gene", + "text": "It is possible that the telomeres of the two nuclei have different functions .", + "entities": [] + }, + { + "id": "1008", + "type": "gene", + "text": "Ki - ras and p53 mutations in pancreatic ductal adenocarcinoma .", + "entities": [ + "Ki - ras", + "p53 mutations" + ] + }, + { + "id": "1009", + "type": "gene", + "text": "Perceptions of illness intrusiveness were significantly higher when both muscle cramp and headache symptoms occurred during one or more assessment intervals as compared to when muscle cramps or headaches , only , occurred .", + "entities": [] + }, + { + "id": "1010", + "type": "gene", + "text": "The maximum stress due to the hygroscopic examination of the composite was 0 . 74 kg / mm2 at equilibrium of the water absorbed of the composite .", + "entities": [] + }, + { + "id": "1011", + "type": "gene", + "text": "Transient transfection assays showed that site A is necessary and sufficient for RXR alpha - mediated transactivation of the apoAI gene basal promoter in human hepatoma HepG2 cells in the presence of RA and that this transactivation is abolished by increasing amounts of cotransfected ARP - 1 .", + "entities": [ + "RXR alpha", + "apoAI gene basal promoter", + "ARP - 1" + ] + }, + { + "id": "1012", + "type": "gene", + "text": "OBJECTIVE : To determine whether administration of misoprostol prevents gastric hemorrhage in healthy dogs treated with high doses of methylprednisolone sodium succinate ( MPSS ) .", + "entities": [] + }, + { + "id": "1013", + "type": "gene", + "text": "Tobramycin 60 mg did not show any remarkable effect , but dibecacin 100 mg produced a slight potentiating effect on the action of d - tubocurarine .", + "entities": [] + }, + { + "id": "1014", + "type": "gene", + "text": "AF showed a mixed nuclear / cytoplasmic pattern of expression in the epithelial , endothelial , and stromal component of the normal breast and benign lesions , whereas an impressive loss of AF expression was noted in in situ and invasive breast cancer and tumoral stroma .", + "entities": [ + "AF", + "AF" + ] + }, + { + "id": "1015", + "type": "gene", + "text": "For each night , the diary allowed the subjective measurement of bedtime , wake time , time in bed ( TIB ) , sleep efficiency , number of minutes of wake after sleep onset ( WASO ) , alertness on awakening , and percentage of morning needing an alarm ( or a person functioning as one ) .", + "entities": [] + }, + { + "id": "1016", + "type": "gene", + "text": "The rat incisor is an excellent model system in which to study amelgenesis .", + "entities": [] + }, + { + "id": "1017", + "type": "gene", + "text": "The measurement of the areas of fibrin , of tissue and fibrinolysis , at the above mentioned times , has been effected at standard magnification ( 15 X ) by an image analyser ( Videoplan ) scale 1 : 8 .", + "entities": [ + "fibrin" + ] + }, + { + "id": "1018", + "type": "gene", + "text": "Transcriptional regulation of the yeast PHO8 promoter in comparison to the coregulated PHO5 promoter .", + "entities": [ + "yeast PHO8 promoter", + "PHO5 promoter" + ] + }, + { + "id": "1019", + "type": "gene", + "text": "Clinical and angiographic examinations in occlusion disease of the great intestinal arteries", + "entities": [] + }, + { + "id": "1020", + "type": "gene", + "text": "Transcription from adenovirus E2 - early promoter is controlled by a unique array of four cis - acting elements which include an atypical TBP site , two E2F sites present in an inverted orientation relative to each other , and an ATF site .", + "entities": [ + "adenovirus E2 - early promoter", + "TBP site", + "E2F sites", + "ATF site" + ] + }, + { + "id": "1021", + "type": "gene", + "text": "Despite the absence of exercise - induced asthma ( EIA ) while breathing WH air , asthmatic patients still had significantly higher mean GH increments than normal subjects ( 9 . 2 vs 2 . 3 ng / ml , P less than 0 . 05 ) .", + "entities": [] + }, + { + "id": "1022", + "type": "gene", + "text": "Both EWS - FLI - 1 and FLI - 1 proteins function as transcription factors that bind specifically to ets sequences ( the ets boxes ) present in promoter elements .", + "entities": [ + "EWS", + "FLI - 1", + "FLI - 1 proteins", + "ets", + "ets" + ] + }, + { + "id": "1023", + "type": "gene", + "text": "Deletion analyses of the pCD41 ORF - A and the use of promoter constructs further mapped an internal functional promoter within the pCD41 sequence that can direct the synthesis of the trans - activating protein .", + "entities": [ + "pCD41 ORF - A", + "pCD41 sequence" + ] + }, + { + "id": "1024", + "type": "gene", + "text": "Mean + / - SD serum VEGF concentrations were significantly higher ( P < 0 . 001 ) in women with PCO and PCOS ( 3 . 4 + / - 0 . 7 and 3 . 2 + / - 0 . 66 ng / ml respectively ) compared with women with normal ovaries ( 2 . 3 + / - 0 . 5 ng / ml ) .", + "entities": [ + "serum VEGF" + ] + }, + { + "id": "1025", + "type": "gene", + "text": "CONCLUSION : TNF alpha , TGF beta , PDGF and IL - 1beta increased LDLr gene expression by increasing sterol - independent and mitogenesis - independent gene transcription .", + "entities": [ + "TNF alpha", + "TGF beta", + "PDGF", + "IL - 1beta", + "LDLr gene" + ] + }, + { + "id": "1026", + "type": "gene", + "text": "SETTING : University of Paris VII hospital . Patient ( s ) : Nine women had embolization for symptomatic myoma , with 12 pregnancies observed .", + "entities": [] + }, + { + "id": "1027", + "type": "gene", + "text": "According to Sugiura ' s classification , they consisted of Type Ia in 63 % , Type Ib in 11 % , Type II in 11 % , and Type III in 16 % .", + "entities": [] + }, + { + "id": "1028", + "type": "gene", + "text": "The deduced amino acid sequence of LvUSF2 is nearly identical to LvUSF1 except at the amino end , where they are sharply divergent .", + "entities": [ + "LvUSF2", + "LvUSF1" + ] + }, + { + "id": "1029", + "type": "gene", + "text": "Sequencing of the three pag - 3 alleles showed that two apparent null alleles encode a nonsense mutation before the zinc fingers and a missense mutation in the fourth zinc finger that changes a coordinating histidine to a tyrosine .", + "entities": [ + "pag - 3 alleles" + ] + }, + { + "id": "1030", + "type": "gene", + "text": "Both can be elevated on a single vascular pedicle based on the superficial temporal artery , the double - layered temporal fascia flap .", + "entities": [] + }, + { + "id": "1031", + "type": "gene", + "text": "Our results indicate that RA - mediated repression of the hMGP gene is due to binding of liganded RAR / RXR to a novel negative RA response element .", + "entities": [ + "hMGP gene", + "RAR", + "RXR" + ] + }, + { + "id": "1032", + "type": "gene", + "text": "The conditions for obtaining titanium dioxide from the substrates titanium tetrachloride and oxygen and applying this to a surgical stainless steel of the type 316L by the plasma assisted chemical vapour deposition method have been determined .", + "entities": [] + }, + { + "id": "1033", + "type": "gene", + "text": "Changes in stimulation levels over time in nucleus 22 cochlear implant users .", + "entities": [] + }, + { + "id": "1034", + "type": "gene", + "text": "The gonadotrope - specific and regulated expression of the GnRH receptor ( GnRH - R ) gene is dependent on multiple transcription factors that interact with the noncanonical GnRH - R activating sequence ( GRAS ) , the activator protein - 1 ( AP - 1 ) element , and the steroidogenic factor - 1 ( SF - 1 ) binding site .", + "entities": [ + "GnRH receptor", + "GnRH - R", + "noncanonical GnRH - R activating sequence", + "GRAS", + "activator protein - 1", + "AP - 1", + "steroidogenic factor - 1", + "SF - 1" + ] + }, + { + "id": "1035", + "type": "gene", + "text": "Oscilloscope triggering circuit for recording long transients at fast sweep speeds .", + "entities": [] + }, + { + "id": "1036", + "type": "gene", + "text": "SFP was significantly elevated in Hn ( s ) .", + "entities": [] + }, + { + "id": "1037", + "type": "gene", + "text": "We exploit the properties of LexA fusion proteins to study the dimerization and DNA - contacting domains of cRel .", + "entities": [ + "LexA fusion proteins", + "cRel" + ] + }, + { + "id": "1038", + "type": "gene", + "text": "The inferred amino acid sequence of the cyanobacterial HemB protein indicates a significant difference in the metal cofactor requirement from the higher - plant enzymes , which was confirmed by overexpression and biochemical analysis .", + "entities": [ + "cyanobacterial HemB protein" + ] + }, + { + "id": "1039", + "type": "gene", + "text": "Ea value was calculated as the ratio of the steady - state end - systolic aortic pressure ( ESAP ) to stroke volume ( thermodilution ) .", + "entities": [] + }, + { + "id": "1040", + "type": "gene", + "text": "We cloned and sequenced the cDNAs against genomic RNA and mRNA for phosphoprotein ( P ) of human parainfluenza type 2 virus ( PIV - 2 ) .", + "entities": [ + "phosphoprotein ( P )" + ] + }, + { + "id": "1041", + "type": "gene", + "text": "cDNA clone from genomic RNA was 1439 nucleotides in length excluding poly ( A ) and was found to have two small open reading frames encoding proteins of 233 and 249 amino acids .", + "entities": [] + }, + { + "id": "1042", + "type": "gene", + "text": "The predicted molecular weight of the polyprotein encoded by ORF1 is 33 kilodaltons ( kDa ) .", + "entities": [] + }, + { + "id": "1043", + "type": "gene", + "text": "Osteocalcin ( OC ) is a matrix calcium - binding protein expressed in osteoblasts and odontoblasts undergoing mineralization .", + "entities": [ + "Osteocalcin", + "OC", + "matrix calcium - binding protein" + ] + }, + { + "id": "1044", + "type": "gene", + "text": "Transcriptional activation of the chicken lysozyme gene by NF - kappa Bp65 ( RelA ) and c - Rel , but not by NF - kappa Bp50 .", + "entities": [ + "chicken lysozyme gene", + "NF - kappa Bp65", + "RelA", + "c - Rel", + "NF - kappa Bp50" + ] + }, + { + "id": "1045", + "type": "gene", + "text": "Incidences of nonfatal stroke , myocardial infarction , angina pectoris und left ventricular hypertrophy could also be lowered .", + "entities": [] + }, + { + "id": "1046", + "type": "gene", + "text": "Both promoters lack a TATA box , and Pint belongs to the MED - 1 class of promoters , which initiate transcription at multiple sites .", + "entities": [ + "Pint", + "MED - 1" + ] + }, + { + "id": "1047", + "type": "gene", + "text": "High plasma AVP levels observed in the two cases suggest that SSRIs stimulate AVP secretion , thereby causing SIADH .", + "entities": [ + "plasma AVP", + "AVP" + ] + }, + { + "id": "1048", + "type": "gene", + "text": "C - SP duration was significantly reduced in ALS patients compared to controls at low stimulation intensity corresponding to an MEP threshold increased by 15 % .", + "entities": [] + }, + { + "id": "1049", + "type": "gene", + "text": "Copyright 1999 Academic Press .", + "entities": [] + }, + { + "id": "1050", + "type": "gene", + "text": "Overall , our results suggest that resistant genotypes exist among the WAD goat population .", + "entities": [] + }, + { + "id": "1051", + "type": "gene", + "text": "At 60 days the amount of gangliosides was on average lower in females than in males , even if with some exception .", + "entities": [] + }, + { + "id": "1052", + "type": "gene", + "text": "Purified PLB showed optimal lyase activity at pH 10 . 0 .", + "entities": [ + "PLB", + "lyase" + ] + }, + { + "id": "1053", + "type": "gene", + "text": "Experimental pancreatitis in pigs .", + "entities": [] + }, + { + "id": "1054", + "type": "gene", + "text": "A prerequisite for the synthesis of sialylated glycoconjugates is the activated sugar - nucleotide cytidine 5 ' - monophosphate N - acetylneuraminic acid ( CMP - Neu5Ac ) , which provides a substrate for Golgi sialyltransferases .", + "entities": [ + "Golgi sialyltransferases" + ] + }, + { + "id": "1055", + "type": "gene", + "text": "Detailed mutagenesis of the element ' s rare - codon / AU - rich sequence boundary revealed that the destabilizing activity of the MATalpha1 IE is observed when the terminal codon of the element ' s rare - codon interval is translated .", + "entities": [ + "MATalpha1 IE" + ] + }, + { + "id": "1056", + "type": "gene", + "text": "Children born from chronic alcoholic mothers have shown behavioral teratogenic effects more frequently than morphological malformations .", + "entities": [] + }, + { + "id": "1057", + "type": "gene", + "text": "Functional analysis of promoter activity of the 5 ' - flanking region of cyclin D2 suggested that the region - 1 , 100 to - 805 including C / EBP , PEA3 , AP2 , NF - Y , c - Myc , and Sp1 may have a major positive regulatory activity for expression of cyclin D2 .", + "entities": [ + "cyclin D2", + "C / EBP", + "PEA3", + "AP2", + "NF - Y", + "c - Myc", + "Sp1", + "cyclin D2" + ] + }, + { + "id": "1058", + "type": "gene", + "text": "Sensitive fluorometric method of determining SH - and S - S - groups when jointly present", + "entities": [] + }, + { + "id": "1059", + "type": "gene", + "text": "Therefore , we have named this gene UBP43 .", + "entities": [ + "UBP43" + ] + }, + { + "id": "1060", + "type": "gene", + "text": "The orbitofrontal , cingulate , and anteromedial part of the dorsal premotor areas were preferentially activated by the self - initiated hand movement task ( SELF ) .", + "entities": [] + }, + { + "id": "1061", + "type": "gene", + "text": "High - mobility - group protein I can modulate binding of transcription factors to the U5 region of the human immunodeficiency virus type 1 proviral promoter .", + "entities": [ + "High - mobility - group protein I", + "U5 region", + "human immunodeficiency virus type 1 proviral promoter" + ] + }, + { + "id": "1062", + "type": "gene", + "text": "19F NMR studies in ABF4 - type layered antiferromagnets .", + "entities": [] + }, + { + "id": "1063", + "type": "gene", + "text": "A Drosophila shc gene product is implicated in signaling by the DER receptor tyrosine kinase .", + "entities": [ + "Drosophila shc gene product", + "DER receptor tyrosine kinase" + ] + }, + { + "id": "1064", + "type": "gene", + "text": "Effect of intraventricular administration of streptolysin O on the electroencephalogram of rabbits .", + "entities": [ + "streptolysin O" + ] + }, + { + "id": "1065", + "type": "gene", + "text": "In addition , carp JAK1 shows higher sequence homology to mammalian JAK1 in both the kinase - like ( JH2 ) and kinase ( JH1 ) domains ( approximately 70 % identity ) .", + "entities": [ + "carp JAK1", + "mammalian JAK1", + "JH2", + "JH1" + ] + }, + { + "id": "1066", + "type": "gene", + "text": "CSF adenosine deaminase activity ( ADA ) was measured at the same time .", + "entities": [ + "adenosine deaminase" + ] + }, + { + "id": "1067", + "type": "gene", + "text": "Symposium on presenile spongy encephalopathies .", + "entities": [] + }, + { + "id": "1068", + "type": "gene", + "text": "Conversely , activated glucocorticoid receptors suppressed the transactivation function of p53 , while transrepression by p53 was largely unaffected .", + "entities": [ + "glucocorticoid receptors", + "p53", + "p53" + ] + }, + { + "id": "1069", + "type": "gene", + "text": "To circumvent this problem , a simple two - step strategy was devised by which essential cis - acting sites like the a sequence can be readily deleted from their natural loci in large viral DNA genomes .", + "entities": [] + }, + { + "id": "1070", + "type": "gene", + "text": "Hex is expressed in the developing liver coincident with the forkhead / winged helix transcription factor , Hepatocyte Nuclear Factor 3beta ( HNF3beta ) .", + "entities": [ + "Hex", + "forkhead", + "winged helix", + "Hepatocyte Nuclear Factor 3beta", + "HNF3beta" + ] + }, + { + "id": "1071", + "type": "gene", + "text": "Plasma levels of protein C , protein S , and antithrombin III in patients with subarachnoid haemorrhage .", + "entities": [ + "protein C", + "protein S", + "antithrombin III" + ] + }, + { + "id": "1072", + "type": "gene", + "text": "Chronic graft - versus - host disease ( cGVHD ) is a major complication of allogeneic hematopoietic cell transplantation .", + "entities": [] + }, + { + "id": "1073", + "type": "gene", + "text": "Observations on saccules of rats exposed to long - term hypergravity .", + "entities": [] + }, + { + "id": "1074", + "type": "gene", + "text": "However , inhibition of both the ERK / RSK and the p38 / MAPKAP kinase 2 pathways completely abolished NGF - induced CREB Ser - 133 phosphorylation .", + "entities": [ + "ERK", + "RSK", + "p38", + "MAPKAP kinase 2", + "NGF", + "CREB" + ] + }, + { + "id": "1075", + "type": "gene", + "text": "The two methods identify the same patients only if micturitional pressures are normal ( 40 to 60 cmH2O ) to high ( over 60 cmH2O ) and the Sussett formula is used with a higher ( 95th centile ) cutoff .", + "entities": [] + }, + { + "id": "1076", + "type": "gene", + "text": "This newly described organism was difficult to identify due to discrepancies between the Vitek and API 20E identification systems .", + "entities": [] + }, + { + "id": "1077", + "type": "gene", + "text": "Total serum calcium was 7 . 8 + / - 0 . 8 mg / dl , whereas ionized calcium was 5 . 7 + / - 0 . 7 mg / dl , phosphorus 3 . 2 + / - 1 . 2 mg / dl , and alkaline phosphatase 149 + / - 48 . 6 U / liter .", + "entities": [ + "alkaline phosphatase" + ] + }, + { + "id": "1078", + "type": "gene", + "text": "Following the injection of PGF2 alpha , heifers were observed visually for signs of estrus at 0730 and 1630 ( 45 min each ) .", + "entities": [] + }, + { + "id": "1079", + "type": "gene", + "text": "Number and size of the myelin structures in the pneumocytes typ II increased simultaneously .", + "entities": [] + }, + { + "id": "1080", + "type": "gene", + "text": "In the first series of experiments , Sprague - Dawley male rats were implanted unilaterally with guide cannulas aimed at the lateral ventricle .", + "entities": [] + }, + { + "id": "1081", + "type": "gene", + "text": "Eight rabbits were exposed to 0 . 7 + / - 0 . 4 mg / m3 Co2 + as CoCl2 and 1 . 2 + / - 0 . 7 mg / m3 Cr3 + as Cr ( NO3 ) 3 ( group Co + Cr ) , eight to 0 . 6 + / - 0 . 5 mg / m3 Co2 + ( group Co ) , and eight to filtered air ( control group ) , for 4 months , 5 days / week , and 6 hr / day .", + "entities": [] + }, + { + "id": "1082", + "type": "gene", + "text": "Tyrosine phosphorylated STATs dimerize and translocate into the nucleus to activate specific genes .", + "entities": [ + "STATs" + ] + }, + { + "id": "1083", + "type": "gene", + "text": "Significant alterations in the vasectomized rats from sham rats included : testicular and epididymal hypertrophy , formation of pathologic vas deferens granulomas , decreased total serum protein , lowered alpha - globulin levels as shown by serum electrophoresis , and increased sperm agglutinin antibody titers .", + "entities": [ + "alpha - globulin", + "agglutinin" + ] + }, + { + "id": "1084", + "type": "gene", + "text": "SH2D1A protein levels are up - regulated by CD40 cross - linking and down - regulated by B cell receptor ligation .", + "entities": [ + "SH2D1A protein", + "CD40", + "B cell receptor" + ] + }, + { + "id": "1085", + "type": "gene", + "text": "EBNA - 2 and the cis - acting CD23 element increased TK - promoted mRNA and did not alter the herpes simplex virus TK promoter transcription start site .", + "entities": [ + "EBNA - 2", + "CD23 element", + "TK", + "herpes simplex virus TK promoter transcription start site" + ] + }, + { + "id": "1086", + "type": "gene", + "text": "Furthermore , our novel observation that expression of a highly activated FGFR3 kinase domain is able to morphologically transform fibroblasts suggests that dysregulation of FGFR3 has the potential to play a role in human neoplasia .", + "entities": [ + "FGFR3 kinase domain", + "FGFR3" + ] + }, + { + "id": "1087", + "type": "gene", + "text": "Clipping resulted in a serious mislocalization of the position of the peak of the epicortical potential field .", + "entities": [] + }, + { + "id": "1088", + "type": "gene", + "text": "Regional insertional mutagenesis of specific genes on the CIC5F11 / CIC2B9 locus of Arabidopsis thaliana chromosome 5 using the Ac / Ds transposon in combination with the cDNA scanning method .", + "entities": [ + "CIC5F11", + "CIC2B9", + "Ac", + "Ds" + ] + }, + { + "id": "1089", + "type": "gene", + "text": "Intron K1 cox1 . 2 is not found in S . cerevisiae and appears at an unique location in K . lactis .", + "entities": [ + "K1 cox1 . 2" + ] + }, + { + "id": "1090", + "type": "gene", + "text": "Another putative HNF3 site in close apposition to a NF1 / CTF site was localized upstream of the silencer - like element .", + "entities": [ + "HNF3 site", + "NF1", + "CTF" + ] + }, + { + "id": "1091", + "type": "gene", + "text": "Monitoring patients with acute leukemia for IL - 1 and TNF levels throughout the clinical course of disease may help clarify the causes of febrile episodes .", + "entities": [ + "IL - 1", + "TNF" + ] + }, + { + "id": "1092", + "type": "gene", + "text": "When this DNA fragment was placed upstream of the chloramphenicol acetyltransferase ( CAT ) reporter gene and transfected into a carp CF cell line , it could drive the synthesis of CAT enzyme 16 times more efficiently than the promoterless pCAT - Basic .", + "entities": [ + "chloramphenicol acetyltransferase", + "CAT", + "CAT enzyme", + "pCAT - Basic" + ] + }, + { + "id": "1093", + "type": "gene", + "text": "Handgrip dynamometry was also carried out in 249 of the patients .", + "entities": [] + }, + { + "id": "1094", + "type": "gene", + "text": "The product of the vpr open reading frame of human immunodeficiency virus type 1 ( HIV - 1 ) is a 15 - kDa , arginine - rich protein that is present in virions in molar quantities equivalent to that of Gag .", + "entities": [ + "vpr open reading frame of human immunodeficiency virus type 1 ( HIV - 1 )", + "Gag" + ] + }, + { + "id": "1095", + "type": "gene", + "text": "Molecular cloning of an amphibian insulin receptor substrate 1 - like cDNA and involvement of phosphatidylinositol 3 - kinase in insulin - induced Xenopus oocyte maturation .", + "entities": [ + "amphibian insulin receptor substrate 1 - like cDNA", + "phosphatidylinositol 3 - kinase", + "insulin" + ] + }, + { + "id": "1096", + "type": "gene", + "text": "A recombinant with a 5 ' end from src and a 3 ' end from ros , called SRC x ROS , transformed chicken embryo fibroblasts ( CEF ) to a spindle shape morphology , mimicking that of UR2 .", + "entities": [ + "src", + "ros", + "SRC", + "ROS", + "UR2" + ] + }, + { + "id": "1097", + "type": "gene", + "text": "The deduced protein sequence is characterized by a putative 16 - residue amino - terminal signal peptide that is cleaved , resulting in a 239 - residue polypeptide .", + "entities": [] + }, + { + "id": "1098", + "type": "gene", + "text": "The authors undertook a retrospective analysis of pathology with quantification of the percentage of papillary serous component ( % PSC ) and p53 expression .", + "entities": [ + "p53" + ] + }, + { + "id": "1099", + "type": "gene", + "text": "IVOX was named as an acronym for intravascular oxygenator .", + "entities": [] + }, + { + "id": "1100", + "type": "gene", + "text": "Conversely , the inactive dAK subunit is progressively activated by 1 ) association with a dGK or dCK subunit and 2 ) the conformationally driven heterotropic affect of dGuo or dCyd bound to the opposing subunit .", + "entities": [ + "dAK subunit", + "dGK", + "dCK subunit", + "dGuo", + "dCyd" + ] + }, + { + "id": "1101", + "type": "gene", + "text": "Plasma fibrinogen was measured by the turbidimetric method in timol turbidimetric units .", + "entities": [ + "fibrinogen" + ] + }, + { + "id": "1102", + "type": "gene", + "text": "Serum levels of testosterone also showed no significant changes by exposure to p , p ' - DDE under the conditions of this study .", + "entities": [] + }, + { + "id": "1103", + "type": "gene", + "text": "Because of the functional conservation of cell cycle control elements , the expression of a vertebrate wee1 or mik1 homolog would be expected to rescue such lethal mutations in yeast .", + "entities": [ + "vertebrate wee1", + "mik1 homolog" + ] + }, + { + "id": "1104", + "type": "gene", + "text": "Our results concluded that 1 ) the two inhibin / activin beta B - subunit mRNAs were transcribed from different initiation sites ; 2 ) both promoters may be controlled by up - stream negative regulatory elements ; and 3 ) neither of these promoters is responsive to cAMP and / or phorbol esters under the conditions employed .", + "entities": [ + "inhibin", + "activin" + ] + }, + { + "id": "1105", + "type": "gene", + "text": "Hisako Minowa who has worked as a psychiatric counsellor in industry for the past 20 years", + "entities": [] + }, + { + "id": "1106", + "type": "gene", + "text": "The amino - terminal region of E1A binds several high molecular weight proteins and inhibits the transcriptional coactivator function of p300 and the homologous cAMP response element ( CRE ) - binding protein .", + "entities": [ + "E1A", + "p300", + "cAMP response element ( CRE ) - binding protein" + ] + }, + { + "id": "1107", + "type": "gene", + "text": "A total of 26 BCG strains , out of them 10 Czechoslovak strains ( 2 lyophilized cultures of BCG of different batch , 6 strains isolated from abscesses of children after BCG - vaccination and 2 strains from fatal cases after BCG - vaccination ) and 16 strains obtained from foreign laboratories , were used .", + "entities": [] + }, + { + "id": "1108", + "type": "gene", + "text": "All patients in the control group showed a significant improvement in their PEFR while only 3 patients in the treated group showed an improvement .", + "entities": [] + }, + { + "id": "1109", + "type": "gene", + "text": "Expression of the src homology 3 ( SH3 ) - encoding , expressed in tumorigenic astrocytes ( SETA ) gene is associated with astrocyte transformation in culture and tumors in the adult brain .", + "entities": [ + "src homology 3", + "SH3", + "SETA" + ] + }, + { + "id": "1110", + "type": "gene", + "text": "CONCLUSION : In our animal model , blood - brain barrier disruption was a reproducible , integral finding of single - fraction , high - dose irradiation injury .", + "entities": [] + }, + { + "id": "1111", + "type": "gene", + "text": "The gene cat - 86 , specifying chloramphenicol - inducible chloramphenicol acetyltransferase , is located on the 1 . 1 - kilobase cloned DNA .", + "entities": [ + "gene cat - 86", + "chloramphenicol - inducible chloramphenicol acetyltransferase" + ] + }, + { + "id": "1112", + "type": "gene", + "text": "The Trk / Nerve Growth Factor receptor mediates the rapid activation of a number of intracellular signaling proteins , including phosphatidylinositol 3 - kinase ( PI 3 - kinase ) .", + "entities": [ + "Trk / Nerve Growth Factor receptor", + "phosphatidylinositol 3 - kinase", + "PI 3 - kinase" + ] + }, + { + "id": "1113", + "type": "gene", + "text": "Treatment was well - tolerated .", + "entities": [] + }, + { + "id": "1114", + "type": "gene", + "text": "Research was carried out on the rheumatoid factors in the serum of 917 patients by means of two tests ( one using polystyrene and one with erythrocytes ) and the results obtained were compared using a method of reference .", + "entities": [ + "rheumatoid factors" + ] + }, + { + "id": "1115", + "type": "gene", + "text": "The discordant behaviour in weakly infected mice was due to the occurrence in some animals of a second phase of more rapid increase of the parasitemia .", + "entities": [] + }, + { + "id": "1116", + "type": "gene", + "text": "Wrist measurement of blood pressure : some critical remarks to oscillometry .", + "entities": [] + }, + { + "id": "1117", + "type": "gene", + "text": "Positive correlations were seen between the measurements for protein intake ( r = . 58 , P = . 0026 ) energy intake ( r = . 78 , P < . 00001 ) , with mean differences of . 066 g / kg / d ( SD . 38 ) 2 . 04 kcal / kg / day ( SD 6 . 67 ) , respectively .", + "entities": [] + }, + { + "id": "1118", + "type": "gene", + "text": "Increase in blood NEFA was further augmented by fat plus AA supplementation , but no changes in concentrations of Lys or Met in blood were found .", + "entities": [] + }, + { + "id": "1119", + "type": "gene", + "text": "During the 2h resuscitation period , extracellular aspartate and glutamate concentrations in the cerebral striatum were higher during hypoxaemic resuscitation ( p = 0 . 044 and p = 0 . 055 , respectively ) than during resuscitation with 21 % O2 or 100 % O2 , suggesting an unfavourable accumulation of potent excitotoxins during hypoxaemic resuscitation .", + "entities": [] + }, + { + "id": "1120", + "type": "gene", + "text": "The mean ( + / - sd ) intra - vesicular pressure ( IVP ) and maximal urethral closure pressures ( MUCP ) were 10 . 3 ( + / - 1 . 7 ) and 129 . 8 ( + / - 19 . 6 ) cmH2O , respectively , and the ratio between MUCP and IVP was 13 . 2 ( + / - 2 . 5 ) .", + "entities": [] + }, + { + "id": "1121", + "type": "gene", + "text": "The results confirm and extend previous work by other researchers .", + "entities": [] + }, + { + "id": "1122", + "type": "gene", + "text": "In comparison of cDNA and genomic sequences four RNA editing events were found in both atp9 genes .", + "entities": [ + "atp9 genes" + ] + }, + { + "id": "1123", + "type": "gene", + "text": "PAI - 1 levels increased significantly in patients who received iohexol but not in those who received ioxaglate .", + "entities": [ + "PAI - 1" + ] + }, + { + "id": "1124", + "type": "gene", + "text": "The resurgence of drug - resistant malaria makes urgent the evaluation of new antimalarial agents .", + "entities": [] + }, + { + "id": "1125", + "type": "gene", + "text": "Comparison of transmembrane and cytoplasmic domains to a third cell - surface proteoglycan , 48K5 from human lung fibroblasts ( Marynen , P . , Zhang , J . , Cassiman , J . , Vanden Berghe , H . , and David , C .", + "entities": [ + "48K5" + ] + }, + { + "id": "1126", + "type": "gene", + "text": "Staining with IF MoAB alone of BAL fluid only seemed to be even more sensitive than silver methenamine staining of BAL , TBB and brushing material .", + "entities": [] + }, + { + "id": "1127", + "type": "gene", + "text": "Chlamydia trachomatis and Chlamydia psittaci were not affected by methanol fixation .", + "entities": [] + }, + { + "id": "1128", + "type": "gene", + "text": "To gain an understanding of the mGSTM2 regulation , we have also cloned and analyzed its promoter region .", + "entities": [ + "mGSTM2" + ] + }, + { + "id": "1129", + "type": "gene", + "text": "Antisense transcription of a murine FGFR - 3 psuedogene during fetal developement .", + "entities": [ + "murine FGFR - 3 psuedogene" + ] + }, + { + "id": "1130", + "type": "gene", + "text": "Here we report that the proline - rich region of CAP is recognized by the SH3 domains of several proteins , including the yeast actin - associated protein Abp1p .", + "entities": [ + "CAP", + "SH3 domains", + "yeast actin - associated protein Abp1p" + ] + }, + { + "id": "1131", + "type": "gene", + "text": "An ASIC - chip for stereoscopic depth analysis in video - real - time based on visual cortical cell behavior .", + "entities": [] + }, + { + "id": "1132", + "type": "gene", + "text": "Second report of the Norwegian Cancer Society .", + "entities": [] + }, + { + "id": "1133", + "type": "gene", + "text": "Two nuclear medicine physicians blinded to the surgical findings interpreted all available images and various Tc - 99m MIBI image combinations at 15 minutes alone ; 15 minutes and 2 hours , 15 minutes and 4 hours ; and 15 minutes and 2 and 4 hours each with and without correlative pertechnetate thyroid imaging .", + "entities": [] + }, + { + "id": "1134", + "type": "gene", + "text": "In 4 spinalized cats , the effects of afferent inputs from hindlimb cutaneous nerves ( sural cutaneous nerve : Sur ) on mono - and poly - synaptic reflex recorded from tail muscle motoneurons were studied before and after spinal lesioning at S2 - 3 level .", + "entities": [] + }, + { + "id": "1135", + "type": "gene", + "text": "Sp1 binds the CTC repeat with an affinity , KD = 0 . 37 nM , at least as high as the consensus GC box .", + "entities": [ + "Sp1" + ] + }, + { + "id": "1136", + "type": "gene", + "text": "Measurements of activity with the radioprotective chamber VA - K - 254 of the osimeter VA - J18", + "entities": [] + }, + { + "id": "1137", + "type": "gene", + "text": "DNA sequence analysis of a 3213 bp BamHI - ClaI fragment revealed that three open reading frames ( ORFs ) were encoded in the same orientation .", + "entities": [ + "BamHI", + "ClaI" + ] + }, + { + "id": "1138", + "type": "gene", + "text": "In the VA - SMV mode , the connection was made with valved conduits from the LV apex ( inflow ) to the ascending aorta ( outflow ) ( n = 11 ) or to the DAo ( n = 12 ) .", + "entities": [] + }, + { + "id": "1139", + "type": "gene", + "text": "Concurrently , we monitored weather conditions and used time - activity budget data of free - living birds and laboratory data on resting metabolic rate to construct time - activity laboratory ( TAL ) estimates of daily energy expenditure ( DEE ) and to partition the verdins ' energy budget into thermoregulatory , activity and basal components .", + "entities": [] + }, + { + "id": "1140", + "type": "gene", + "text": "Enhanced hepatic portal blood flow induced by prostaglandin E1 following liver transplantation in pigs .", + "entities": [] + }, + { + "id": "1141", + "type": "gene", + "text": "Since September 1980 to June 1983 we have treated 32 patients with ovarian cancer .", + "entities": [] + }, + { + "id": "1142", + "type": "gene", + "text": "Family environment was an important influence on interpersonal relationships , substance use , and social support .", + "entities": [] + }, + { + "id": "1143", + "type": "gene", + "text": "Although neither constitutively activated MEK ( MEK - 2E ) nor v - Src was sufficient individually to differentiate the H19 - 7 cells , coexpression of constitutively activated MEK and v - Src induced neurite outgrowth .", + "entities": [ + "MEK", + "MEK - 2E", + "v - Src", + "MEK", + "v - Src" + ] + }, + { + "id": "1144", + "type": "gene", + "text": "( 3 ) .", + "entities": [] + }, + { + "id": "1145", + "type": "gene", + "text": "Hydropathy analysis of KCC1 indicates structural homology to NKCC , including 12 transmembrane domains , a large extracellular loop with potential N - linked glycosylation sites , and cytoplasmic N - and C - terminal regions .", + "entities": [ + "KCC1", + "NKCC" + ] + }, + { + "id": "1146", + "type": "gene", + "text": "Encapsidation of poliovirus replicons encoding the complete human immunodeficiency virus type 1 gag gene by using a complementation system which provides the P1 capsid protein in trans .", + "entities": [ + "human immunodeficiency virus type 1 gag gene", + "P1 capsid protein" + ] + }, + { + "id": "1147", + "type": "gene", + "text": "The rhaB transcription start site was mapped to - 24 relative to the start of translation .", + "entities": [ + "rhaB transcription start site" + ] + }, + { + "id": "1148", + "type": "gene", + "text": "We showed that Stat3 and Stat3beta were affinity purified using phosphopeptides containing Y704 and Y744 but not by nonphosphorylated peptide analogues or by phosphopeptides containing Y729 and Y764 .", + "entities": [ + "Stat3", + "Stat3beta" + ] + }, + { + "id": "1149", + "type": "gene", + "text": "MK - 927 : a topically active ocular hypotensive carbonic anhydrase inhibitor .", + "entities": [ + "carbonic anhydrase" + ] + }, + { + "id": "1150", + "type": "gene", + "text": "Neither the reaction of monosaccharides nor the disaccharides with beta - alanine resulted in the formation of maltol .", + "entities": [] + }, + { + "id": "1151", + "type": "gene", + "text": "The treatments were 60 mg t . i . d . and 120 mg t . i . d . during 14 days ' treatment , with the last dose pulsed with 1 . 85 MBq [ 14C ] diltiazem .", + "entities": [] + }, + { + "id": "1152", + "type": "gene", + "text": "These genes were expressed in a Saccharomyces cerevisiae mutant in which the endogenous ferrochelatase gene ( HEM15 ) had been deleted , and the phenotypes of the transformants were characterized .", + "entities": [ + "endogenous ferrochelatase gene", + "HEM15" + ] + }, + { + "id": "1153", + "type": "gene", + "text": "Eleven patients tested positive for the hepatitis B surface antigen ( HBsAg ) .", + "entities": [ + "hepatitis B surface antigen", + "HBsAg" + ] + }, + { + "id": "1154", + "type": "gene", + "text": "There was a weak significant correlation between TGF beta 1 levels and normal cell radiosensitivity ( lymphocyte SF2 ) .", + "entities": [ + "TGF beta 1" + ] + }, + { + "id": "1155", + "type": "gene", + "text": "The membrane - distal cytoplasmic region of human granulocyte colony - stimulating factor receptor is required for STAT3 but not STAT1 homodimer formation .", + "entities": [ + "human granulocyte colony - stimulating factor receptor", + "STAT3", + "STAT1 homodimer" + ] + }, + { + "id": "1156", + "type": "gene", + "text": "Further studies demonstrated that the PPARalpha ligand 8 ( S ) - hydroxyeicosatetraenoic acid strongly promotes the interaction of PPARalpha with the co - activator RIP - 140 but decreases the interaction of PPARalpha with the co - repressor SMRT .", + "entities": [ + "PPARalpha", + "PPARalpha", + "RIP - 140", + "PPARalpha", + "SMRT" + ] + }, + { + "id": "1157", + "type": "gene", + "text": "They were found to be seropositive for antibodies to hepatitis C virus by second - generation testing ( RIBA 2 , Ortho Diagnostic Systems Inc , Westwood , MA ) .", + "entities": [] + }, + { + "id": "1158", + "type": "gene", + "text": "The level of the SUP4A53T61 transcript was threefold higher in the tap1 - 1 mutant than in the wild type .", + "entities": [ + "SUP4A53T61 transcript", + "tap1 - 1 mutant" + ] + }, + { + "id": "1159", + "type": "gene", + "text": "In Xenopus , BMPs act as epidermal inducers and also as negative regulators of neurogenesis .", + "entities": [ + "BMPs" + ] + }, + { + "id": "1160", + "type": "gene", + "text": "Mature tobacco L12 protein has 44 % amino acid identity with ribosomal protein L7 / L12 of Escherichia coli .", + "entities": [ + "Mature tobacco L12 protein", + "L7", + "L12" + ] + }, + { + "id": "1161", + "type": "gene", + "text": "Both P5CDh cDNA clones detect a single 3 . 2 - kb transcript on Northern blots of multiple human tissues , indicating the long cDNA containing the 3 ' - untranslated intron represents the predominant transcript .", + "entities": [ + "P5CDh cDNA" + ] + }, + { + "id": "1162", + "type": "gene", + "text": "Silicosis mortality", + "entities": [] + }, + { + "id": "1163", + "type": "gene", + "text": "Lung mesenchyme serves as a ' compleat ' inducer of lung morphogenesis by secreting soluble peptide growth factors .", + "entities": [] + }, + { + "id": "1164", + "type": "gene", + "text": "D .", + "entities": [] + }, + { + "id": "1165", + "type": "gene", + "text": "Therefore , to understand how ErbB1 / ErbB2 signaling contributes to this process , we used the ErbB kinase inhibitor AG1478in ErbB2 - dependent BT - 474 and SKBR - 3 human breast cancer cells .", + "entities": [ + "ErbB1", + "ErbB2", + "ErbB kinase", + "ErbB2" + ] + }, + { + "id": "1166", + "type": "gene", + "text": "Counter - current heat exchange in the respiratory passages : effect on water and heat balance .", + "entities": [] + }, + { + "id": "1167", + "type": "gene", + "text": "Non - complement - dependent sperm - immobilizing activity was also detected in the cervical mucus of several patients .", + "entities": [] + }, + { + "id": "1168", + "type": "gene", + "text": "Psychiatry and the skin .", + "entities": [] + }, + { + "id": "1169", + "type": "gene", + "text": "Hence , scs32 only partially suppressed the ts phenotype and was unable to suppress the Ino - phenotype of rpo26 - 31 .", + "entities": [ + "scs32", + "rpo26 - 31" + ] + }, + { + "id": "1170", + "type": "gene", + "text": "The provisional reports are based mainly upon macroscopic findings , whereas the final reports include the information provided by supplementary investigations such as microscopy , histochemistry , more rarely electron microscopy , immunohistochemistry and / or microbiology .", + "entities": [] + }, + { + "id": "1171", + "type": "gene", + "text": "These data indicate that the third intracellular loop of the rat GnRH - R is involved in receptor G ( q / 11 ) protein coupling and / or selectivity , and in the GGH ( 3 ) 1 ' cell line , this loop is also involved in signal transduction mediated through the Gs protein pathway .", + "entities": [ + "rat GnRH - R", + "receptor G ( q / 11 ) protein", + "Gs" + ] + }, + { + "id": "1172", + "type": "gene", + "text": "The Nur77 protein can act as a potent transcription activator and may function to regulate the expression of downstream genes in response to extracellular stimuli .", + "entities": [ + "Nur77 protein" + ] + }, + { + "id": "1173", + "type": "gene", + "text": "A beta2 RARE reporter construct in which the methylation - susceptible cytosines in the sense strand were replaced by thymine displayed marked loss of activity in a replicated chromatin - dependent manner .", + "entities": [ + "beta2 RARE reporter construct" + ] + }, + { + "id": "1174", + "type": "gene", + "text": "The homeobox gene ATK1 of Arabidopsis thaliana is expressed in the shoot apex of the seedling and in flowers and inflorescence stems of mature plants .", + "entities": [ + "homeobox gene ATK1" + ] + }, + { + "id": "1175", + "type": "gene", + "text": "Mutational analysis showed that the U - box , like the RING finger in other proteins , forms the physical basis for the interaction with E2 enzymes .", + "entities": [ + "E2 enzymes" + ] + }, + { + "id": "1176", + "type": "gene", + "text": "Institution of both intravenous and intracisternal administration of amphotericin B and possibly concomitant intravenous administration of dexamethasone may be warranted in situations in which the association of C . immitis with CNS vasculitis or encephalitis appears likely before serologic or cultural confirmation of C . immitis infection involving the CNS is available .", + "entities": [] + }, + { + "id": "1177", + "type": "gene", + "text": "One of these small inteins might be inactive or a \" pseudo intein . \" The results suggest a modular architecture for inteins , clarify their origin and relationship to other protein families , and extend recent experimental findings on the functional roles of intein N , C , and EN motifs .", + "entities": [ + "small inteins", + "\" pseudo intein . \"", + "inteins", + "intein N , C , and EN motifs" + ] + }, + { + "id": "1178", + "type": "gene", + "text": "Judicious use of laboratory testing , including monitoring of CD4 cell counts , is recommended .", + "entities": [ + "CD4" + ] + }, + { + "id": "1179", + "type": "gene", + "text": "The effect of Rho on AP - 1 is independent of the mitogen - activated protein kinase pathway , as a dominant - negative MEK and a MEK inhibitor ( PD98059 ) did not affect Rho - induced AP - 1 activity .", + "entities": [ + "Rho", + "AP - 1", + "mitogen - activated protein kinase", + "dominant - negative MEK", + "MEK", + "Rho", + "AP - 1" + ] + }, + { + "id": "1180", + "type": "gene", + "text": "A second , novel C subunit ( CeCAT alpha ' , 374 residues ) has a unique 56 - residue carboxyl - terminal region that is generated by the alternative splicing of the C pre - mRNA .", + "entities": [ + "CeCAT alpha '", + "C pre - mRNA" + ] + }, + { + "id": "1181", + "type": "gene", + "text": "The results demonstrate that ( i ) no intact capsids were assembled when the full - length or a truncated ( missing the C - terminal 65 amino acids ) UL80 . 5 protein was tested ; ( ii ) when the C - terminal 65 amino acids of the UL80 . 5 protein were replaced with the C - terminal 25 amino acids of the UL26 . 5 protein , intact capsids were made and direct interaction of the UL80 . 5 protein with VP5 was detected ; ( iii ) assembly of intact capsids was demonstrated when the sequence of the last 12 amino acids of the UL80 . 5 protein was changed from RRIFVA ALNKLE to RRIFVAAMMKLE ; ( iv ) self - interaction of the scaffold proteins is mediated by sequences N terminal to the maturation cleavage site ; and ( v ) the UL26 . 5 and UL80 . 5 proteins will not coassemble into scaffold structures .", + "entities": [ + "UL80 . 5 protein", + "UL80 . 5 protein", + "UL26 . 5 protein", + "UL80 . 5 protein", + "VP5", + "UL80 . 5 protein", + "UL26 . 5", + "UL80 . 5 proteins" + ] + }, + { + "id": "1182", + "type": "gene", + "text": "The applicability of laparoscopic donor nephrectomy ( LDN ) has not been assessed in the obese donor .", + "entities": [] + }, + { + "id": "1183", + "type": "gene", + "text": "Duch , and F .", + "entities": [] + }, + { + "id": "1184", + "type": "gene", + "text": "Gonadal dysfunction in patients with ataxia telangiectasia .", + "entities": [] + }, + { + "id": "1185", + "type": "gene", + "text": "We propose that two pathways regulate Stat5 serine phosphorylation , one that is prolactin - activated and PD98059 - resistant and one that is constitutively active and PD98059 - sensitive and preferentially targets Stat5a .", + "entities": [ + "Stat5", + "prolactin", + "Stat5a" + ] + }, + { + "id": "1186", + "type": "gene", + "text": "Clb2 / Cdc28 kinase is not required for the repression of MCB - binding factor transcriptional activity in G2 and M phase .", + "entities": [ + "Clb2", + "Cdc28", + "MCB - binding factor" + ] + }, + { + "id": "1187", + "type": "gene", + "text": "Parasitological post - mortem examination of all seropositive animals showed five and seven false - positive animals when E / S and CWE antigens were used , respectively .", + "entities": [ + "E / S and CWE antigens" + ] + }, + { + "id": "1188", + "type": "gene", + "text": "Our study was addressed to the synthesis of some derivatives of this sequence in order to obtain both peptide substrates suitable for the detection of the Src - like tyrosine kinase activity and active site - directed inhibitors specific for this class of enzymes .", + "entities": [ + "Src", + "tyrosine kinase" + ] + }, + { + "id": "1189", + "type": "gene", + "text": "In unc - 4 mutants , VA motor neurons assume the pattern of synaptic input normally reserved for their lineal sister cells , the VB motor neurons ; the loss of normal input to the VAs produces a distinctive backward movement defect .", + "entities": [ + "unc - 4 mutants" + ] + }, + { + "id": "1190", + "type": "gene", + "text": "Lesions were made by pressure injection of kainic acid into the SOC through a stereotaxically positioned glass micropipette .", + "entities": [] + }, + { + "id": "1191", + "type": "gene", + "text": "Furthermore , no transcripts of the same size and having the same developmental profile as those generated by the wild - type E10 fragment were identified by probes covering the remainder of the cloned region .", + "entities": [ + "wild - type E10 fragment" + ] + }, + { + "id": "1192", + "type": "gene", + "text": "To investigate the potential role of SP1 , we examined nuclear extracts from HCMV - infected cells .", + "entities": [ + "SP1" + ] + }, + { + "id": "1193", + "type": "gene", + "text": "These results were robust to changes in the baseline assumptions of the model .", + "entities": [] + }, + { + "id": "1194", + "type": "gene", + "text": "Of the six cases of malignant polyposis , none were identified using CT , and only two were diagnosed by small bowel follow - through .", + "entities": [] + }, + { + "id": "1195", + "type": "gene", + "text": "Possibilities and outlook for wrist joint endoprosthesis", + "entities": [] + }, + { + "id": "1196", + "type": "gene", + "text": "Thus , in normal intestinal epithelial goblet cells , TbetaRI and TbetaRII can respond to autocrine but not exogenous TGF - beta without the participation of TbetaRIII .", + "entities": [ + "TbetaRI", + "TbetaRII", + "TGF - beta", + "TbetaRIII" + ] + }, + { + "id": "1197", + "type": "gene", + "text": "We characterized three Arabidopsis thaliana cDNA clones that could rescue the sterile phenotype of the Schizosaccharomyces pombe pde1 mutant , which is defective in cAMP phosphodiesterase .", + "entities": [ + "Schizosaccharomyces pombe pde1 mutant", + "cAMP phosphodiesterase" + ] + }, + { + "id": "1198", + "type": "gene", + "text": "Intravenous versus oral administration of amitriptyline in patients with major depression .", + "entities": [] + }, + { + "id": "1199", + "type": "gene", + "text": "The antioxidant agent pyrrolidine dithiocarbamate ( PDTC ) has been shown to protect endothelial cells ( EC ) from pro - inflammatory - induced and pro - oxidant - induced NF - kappaB activation .", + "entities": [ + "NF - kappaB" + ] + }, + { + "id": "1200", + "type": "gene", + "text": "The differences were as follows : for overall response rate p = 0 . 004 ; power ( for p = 0 . 05 ) 85 % ; for survival p = 0 . 09 ; for grade IV granulocytopenia p = 0 . 3 ; and for febrile neutropenia p = 0 . 61 .", + "entities": [] + }, + { + "id": "1201", + "type": "gene", + "text": "We now provide evidence for physical and functional interaction between Doa4 and the proteasome .", + "entities": [ + "Doa4" + ] + }, + { + "id": "1202", + "type": "gene", + "text": "There is a national effort to begin to ask all female patients about family violence .", + "entities": [] + }, + { + "id": "1203", + "type": "gene", + "text": "By far - Western analysis and coimmunoprecipitation studies , we demonstrate that ZNF74 interacts , via its zinc finger domain , with the hyperphosphorylated largest subunit of RNA polymerase II ( pol IIo ) but not with the hypophosphorylated form .", + "entities": [ + "ZNF74", + "RNA polymerase II", + "pol IIo" + ] + }, + { + "id": "1204", + "type": "gene", + "text": "Framingham Type A behavior was positively associated with diastolic blood pressure ( r = 0 . 17 , p less than 0 . 05 ) among the women .", + "entities": [] + }, + { + "id": "1205", + "type": "gene", + "text": "The spontaneous mutation blocking pca gene expression was located in the promoter for the pca operon .", + "entities": [ + "pca gene", + "pca operon" + ] + }, + { + "id": "1206", + "type": "gene", + "text": "Desmethylferrochloroquine 1a and didesmethylferrochloroquine 2 would be more potent against schizontocides than CQ in vitro against two strains ( HB3 and Dd2 ) of Plasmodium falciparum .", + "entities": [] + }, + { + "id": "1207", + "type": "gene", + "text": "The starting point is the consideration that the conceptions underlying the ICIDH are not suitable to serve as a mainstay of a model for diagnostics in rehabilitation because they do not reflect essential characteristics of the diagnostic process which is the basis for intervention .", + "entities": [] + }, + { + "id": "1208", + "type": "gene", + "text": "Responsiveness to beta - 2 agonist therapy was retained with both agents ( p less than 0 . 05 ) .", + "entities": [] + }, + { + "id": "1209", + "type": "gene", + "text": "In most subjects , markers of bone formation and resorption were normal .", + "entities": [] + }, + { + "id": "1210", + "type": "gene", + "text": "However , changing the half - site to the consensus sequence AGGTCA ( IRper - 1 ) increased binding of AaEcR . AaUSP 10 - fold over IRhsp - 1 and , at the same time , reduced the stringency of the spacer length requirement , with IRper - 0 to IRper - 5 showing detectable binding .", + "entities": [ + "AaEcR . AaUSP" + ] + }, + { + "id": "1211", + "type": "gene", + "text": "The prevalence of hepatitis C virus ( HCV ) infection is relatively low in childhood , with anti - HCV prevalence rates of 0 . 1 - 0 . 4 % in the Western world .", + "entities": [ + "anti - HCV" + ] + }, + { + "id": "1212", + "type": "gene", + "text": "Effect of alcohol on minimal effective nCPAP pressure", + "entities": [] + }, + { + "id": "1213", + "type": "gene", + "text": "In hypertensive nephrosclerosis , therapy containing an ACEI alone or in combination significantly reduces the incidence of renal events .", + "entities": [] + }, + { + "id": "1214", + "type": "gene", + "text": "CCAAT displacement protein binds to and negatively regulates human papillomavirus type 6 E6 , E7 , and E1 promoters .", + "entities": [ + "CCAAT displacement protein", + "E6", + "E7", + "E1" + ] + }, + { + "id": "1215", + "type": "gene", + "text": "The determination of physical performance capacity was based on W170 , W85 % and on predicted VO2 max measured with continuously increasing work load on a bicycle ergometer .", + "entities": [] + }, + { + "id": "1216", + "type": "gene", + "text": "Nevertheless , antibodies directed against an epitope - tagged version of Prp42p specifically precipitate U1 snRNA from yeast extracts .", + "entities": [ + "Prp42p", + "U1 snRNA" + ] + }, + { + "id": "1217", + "type": "gene", + "text": "In the free - swimming rotatory test mice spend most of the time swimming close to the wall of the container attempting to escape from an aversive test situation .", + "entities": [] + }, + { + "id": "1218", + "type": "gene", + "text": "The major myosin - binding domain of skeletal muscle MyBP - C ( C protein ) resides in the COOH - terminal , immunoglobulin C2 motif .", + "entities": [ + "myosin - binding domain", + "skeletal muscle MyBP - C", + "C protein", + "C2 motif" + ] + }, + { + "id": "1219", + "type": "gene", + "text": "The c - myc and skeletal alpha - actin gene promoters contain YY1 binding sites thought to act either as positive or negative cis - acting elements .", + "entities": [ + "c - myc", + "skeletal alpha - actin gene promoters", + "YY1 binding sites" + ] + }, + { + "id": "1220", + "type": "gene", + "text": "Functional analysis of various PTP - deficient DT40 B cell lines stably expressing wild - type chimeric Fc gamma RIIB1 - PECAM - 1 receptor indicated that cytoplasmic Src homology 2 - domain - containing phosphatases , SHP - 1 and SHP - 2 , were both necessary and sufficient to deliver inhibitory negative regulation upon coligation of BCR complex with inhibitory receptor .", + "entities": [ + "PTP", + "Fc gamma RIIB1 - PECAM - 1 receptor", + "cytoplasmic Src homology 2 - domain - containing phosphatases", + "SHP - 1", + "SHP - 2", + "BCR complex" + ] + }, + { + "id": "1221", + "type": "gene", + "text": "The alternative exon introduces the novel carboxyl terminus and a new translation stop signal , while simultaneously converting the coding sequence for 40 carboxyl - terminal residues in CeCAT alpha into 3 ' - untranslated nucleotides .", + "entities": [ + "CeCAT alpha" + ] + }, + { + "id": "1222", + "type": "gene", + "text": "We have isolated and characterised a differentially - regulated gene family in the protozoan parasite Leishmania major .", + "entities": [] + }, + { + "id": "1223", + "type": "gene", + "text": "The authors have tested the interference of the hemoglobin by two routine methods ( Berthelot classic and Berthelot modified ) for the determination of plasmatic urea .", + "entities": [ + "hemoglobin" + ] + }, + { + "id": "1224", + "type": "gene", + "text": "The appropriate use and benefits of bile acid sequestrants , nicotinic acid , fibric acids , 3 - hydroxy - 3 - methylglutaryl coenzyme A ( HMG - CoA ) reductase inhibitors , and probucol are individually discussed , whereas nonpharmacologic approaches used in conjunction with the drugs are recommended emphatically .", + "entities": [ + "3 - hydroxy - 3 - methylglutaryl coenzyme A ( HMG - CoA ) reductase" + ] + }, + { + "id": "1225", + "type": "gene", + "text": "The single site of glycosylation is located near the C - terminus in the N - glycosylation sequon - Asn - Cys - Ser - in which Cys forms part of a disulphide bridge .", + "entities": [] + }, + { + "id": "1226", + "type": "gene", + "text": "Antileukoproteinase ( ALP ) is a low mol wt mucosal secretory protein which , in human tissues , inhibits the activities of the neutral serine lysosomal proteinases elastase and cathepsin - G .", + "entities": [ + "Antileukoproteinase", + "ALP", + "elastase", + "cathepsin - G" + ] + }, + { + "id": "1227", + "type": "gene", + "text": "The effects of L655 , 240 , a selective thromboxane and prostaglandin endoperoxide antagonist , on ischemia - and reperfusion - induced cardiac arrhythmias .", + "entities": [] + }, + { + "id": "1228", + "type": "gene", + "text": "Many of these landfill operations were undertaken in the early 1950s and 1960s , when knowledge regarding the safe and prolonged containment of the waste buried was nonexistent or minimal at best .", + "entities": [] + }, + { + "id": "1229", + "type": "gene", + "text": "Redistribution of mannosidase I was also observed in cells incubated at 15 degrees C .", + "entities": [ + "mannosidase I" + ] + }, + { + "id": "1230", + "type": "gene", + "text": "Organization of the human LU gene and molecular basis of the Lu ( a ) / Lu ( b ) blood group polymorphism .", + "entities": [ + "human LU gene", + "Lu ( a )", + "Lu ( b )" + ] + }, + { + "id": "1231", + "type": "gene", + "text": "Interestingly , virions also contained smaller proteins that reacted with antibodies specific for the accessory proteins as well as SN and CAT fusion partners .", + "entities": [ + "SN", + "CAT fusion" + ] + }, + { + "id": "1232", + "type": "gene", + "text": "MEASUREMENTS AND MAIN RESULTS : The two groups were similar on entry into the study , including mean FEV1 measurements ( 0 . 70 L atropine / 0 . 60 L metaproterenol , P greater than . 05 ) .", + "entities": [] + }, + { + "id": "1233", + "type": "gene", + "text": "In Experiment 2 scopolamine hydrobromide , 0 . 5 and 1 . 0 mg / kg i . p . , was administered 1 h before each electrical stimulation until each rat showed the stage - 3 seizure .", + "entities": [] + }, + { + "id": "1234", + "type": "gene", + "text": "So far no problems with multiply resistant strains have developed .", + "entities": [] + }, + { + "id": "1235", + "type": "gene", + "text": "Sources of noise in these signals were evaluated in preparations stained with the potentiometric probe RH - 414 .", + "entities": [] + }, + { + "id": "1236", + "type": "gene", + "text": "Two studies on the relationship between taking a commercial coaching course and performance on the Medical College Admission Test ( MCAT ) are reported .", + "entities": [] + }, + { + "id": "1237", + "type": "gene", + "text": "We further demonstrate that RU486 - PR - B interacts physically with NCoR in vitro .", + "entities": [ + "PR - B", + "NCoR" + ] + }, + { + "id": "1238", + "type": "gene", + "text": "After acclimation , resting supine and sitting DPB decreased ( P less than 0 . 05 ) by 6 and 9 mmHg , respectively .", + "entities": [] + }, + { + "id": "1239", + "type": "gene", + "text": "A system is described in which the volume flow rate of blood in a vessel is determined using transverse colour Doppler ultrasound imaging .", + "entities": [] + }, + { + "id": "1240", + "type": "gene", + "text": "Rabbit eyes were removed and held in temperature - regulated chambers and irrigated with saline .", + "entities": [] + }, + { + "id": "1241", + "type": "gene", + "text": "Significance of cytokine production and adhesion molecules in malarial immunopathology .", + "entities": [] + }, + { + "id": "1242", + "type": "gene", + "text": "In addition , double mutants with either dim1 - delta or dim2 - 1 and the endocytosis mutants end4 - 1 or act1 - 1 displayed synthetic growth defects , indicating that the DIM gene products function in a common or parallel endocytic pathway .", + "entities": [ + "dim1 - delta", + "dim2 - 1", + "mutants end4 - 1", + "act1 - 1", + "DIM gene products" + ] + }, + { + "id": "1243", + "type": "gene", + "text": "Three of the proteins involved in checkpoint signaling , Rad1 , Hus1 , and Rad9 , have been shown to interact by immunoprecipitation and yeast two - hybrid studies .", + "entities": [ + "Rad1", + "Hus1", + "Rad9" + ] + }, + { + "id": "1244", + "type": "gene", + "text": "During V - A bypass , hemodynamics were stable .", + "entities": [] + }, + { + "id": "1245", + "type": "gene", + "text": "We also show that in fusions with the DNA binding domain of GAL4 , full activity requires the entire BHV - alpha TIF , although both amino and carboxyl termini display some activity on their own .", + "entities": [ + "GAL4", + "BHV - alpha TIF" + ] + }, + { + "id": "1246", + "type": "gene", + "text": "In a randomized double - blind cross - over study , the subjects received theophylline 5 mg . kg - 1 per day with omeprazole 20 mg per day or identical placebo during two periods , each of 7 days , separated by a washout period of 7 days .", + "entities": [] + }, + { + "id": "1247", + "type": "gene", + "text": "These results suggested that NfxB negatively autoregulates the expression of nfxB itself .", + "entities": [ + "NfxB", + "nfxB" + ] + }, + { + "id": "1248", + "type": "gene", + "text": "The slower - electrophoretic - mobility form of p68 was absent in human cells in G1 / S and appeared as the cells entered G2 / M .", + "entities": [ + "p68" + ] + }, + { + "id": "1249", + "type": "gene", + "text": "The attainment of sexual maturity in terms of secondary sexual characteristics , the production of spermatozoa in the male , and the cyclical female pattern with release of ova are end - points of the developmental process .", + "entities": [] + }, + { + "id": "1250", + "type": "gene", + "text": "The method involves preliminary isolation of oxiracetam and internal standard from plasma by solid - phase extraction prior to the formation of their n - propyl carbamate derivatives .", + "entities": [] + }, + { + "id": "1251", + "type": "gene", + "text": "Tobacco mosaic virus - infected tobacco ( Nicotiana tabacum var .", + "entities": [] + }, + { + "id": "1252", + "type": "gene", + "text": "Neuronal signaling properties are largely determined by the quantity and combination of ion channels expressed .", + "entities": [] + }, + { + "id": "1253", + "type": "gene", + "text": "During an 8 - wk follow - up , parasites reappeared in 10 patients , 5 after each drug , between 1 and 7 wk after treatment .", + "entities": [] + }, + { + "id": "1254", + "type": "gene", + "text": "The experimental end points were the time required for treated tumors to reach 3 times their treatment size , the survival of stem cells in the duodenal crypts , and the breathing rate measured early ( 19 - 23 weeks ) and late ( 41 - 46 weeks ) after treatment .", + "entities": [] + }, + { + "id": "1255", + "type": "gene", + "text": "The real challenge for the future will be the management of patients who do not respond to first - line treatment .", + "entities": [] + }, + { + "id": "1256", + "type": "gene", + "text": "Through deletion mutagenesis , we identify amino acids 2003 to 2212 of CBP , which we call carboxy - terminal region 2 ( CR2 ) , as the minimal region for Tax interaction .", + "entities": [ + "CBP", + "Tax" + ] + }, + { + "id": "1257", + "type": "gene", + "text": "Pulmonary embolectomy and lung transplantation are the main indications for the use of heart - lung - machine .", + "entities": [] + }, + { + "id": "1258", + "type": "gene", + "text": "We have isolated a binding partner for the Fanconi anemia group C protein ( FANCC ) by yeast two - hybrid screening .", + "entities": [ + "Fanconi anemia group C protein", + "FANCC" + ] + }, + { + "id": "1259", + "type": "gene", + "text": "Anti - NPROSP - C also exclusively detected time - dependent appearances of 5 - 10 - kDa proSP - C forms in lamellar bodies and homogenates .", + "entities": [ + "Anti - NPROSP - C", + "5 - 10 - kDa proSP - C" + ] + }, + { + "id": "1260", + "type": "gene", + "text": "The locus encoding the XD gene ( designated Xd ) was mapped to the distal part of mouse chromosome 17 by haplotype analysis of 114 interspecific backcross mice .", + "entities": [ + "XD gene", + "Xd" + ] + }, + { + "id": "1261", + "type": "gene", + "text": "The hepatitis A virus antibody ( anti - HAV ) in chronic diffuse liver diseases", + "entities": [ + "hepatitis A virus antibody", + "anti - HAV" + ] + }, + { + "id": "1262", + "type": "gene", + "text": "Treatment with MK - 801 induced a burst suppression in the EEG and a transient drop ( 11 . 4 + / - 6 . 5 mm Hg ) in the mean arterial pressure .", + "entities": [] + }, + { + "id": "1263", + "type": "gene", + "text": "Low - grade gastric MALT lymphoma and helicobacter heilmannii ( Gastrospirillum hominis", + "entities": [] + }, + { + "id": "1264", + "type": "gene", + "text": "1 .", + "entities": [] + }, + { + "id": "1265", + "type": "gene", + "text": "Low - dose aspirin and recurrent miscarriage .", + "entities": [] + }, + { + "id": "1266", + "type": "gene", + "text": "The mean waiting time to receive the pancreas transplant was 244 days for SPK and 167 days for PAK recipients ( P = 0 . 001 ) .", + "entities": [] + }, + { + "id": "1267", + "type": "gene", + "text": "Copyright 1998 Academic Press .", + "entities": [] + }, + { + "id": "1268", + "type": "gene", + "text": "A follow - up study of 22 patients with Ebstein ' s anomaly has been performed .", + "entities": [] + }, + { + "id": "1269", + "type": "gene", + "text": "The enzymatic response of neutrophils and monocytes was similar although the magnitude of the NADPH oxidase activity was significantly higher in neutrophils than in monocytes .", + "entities": [ + "NADPH oxidase" + ] + }, + { + "id": "1270", + "type": "gene", + "text": "The region between DXS52 and Factor VIII gene in the human Xq28 chromosomal band contains a G + C - rich isochore to which many genes have been mapped .", + "entities": [ + "DXS52", + "Factor VIII gene" + ] + }, + { + "id": "1271", + "type": "gene", + "text": "Thigh girth correlated positively with HDL and HDL2 - C and mass , and with LDL particle size among women .", + "entities": [ + "HDL", + "HDL2 - C", + "LDL" + ] + }, + { + "id": "1272", + "type": "gene", + "text": "Activation mediated by Cat8p was no longer detectable in a cat1 mutant .", + "entities": [ + "Cat8p", + "cat1 mutant" + ] + }, + { + "id": "1273", + "type": "gene", + "text": "Common foot pathologies are heel pain , metatarsalgia , hammertoes and clawtoes , bunions , hallux rigidus , corns and calluses , nail pathologies , arthritis , and neuropathies .", + "entities": [] + }, + { + "id": "1274", + "type": "gene", + "text": "A deproteinization procedure was coupled with a reversed - phase HPLC separation using a 250x4 . 6 mm I . D .", + "entities": [] + }, + { + "id": "1275", + "type": "gene", + "text": "255 - 61 .", + "entities": [] + }, + { + "id": "1276", + "type": "gene", + "text": "Studies of biochemical and morphological changes ( between normal and treated animals ) show that chrysotile induces an increase in the lung free cell population and pulmonary surfactant levels .", + "entities": [] + }, + { + "id": "1277", + "type": "gene", + "text": "Characteristics of lipase activity .", + "entities": [ + "lipase" + ] + }, + { + "id": "1278", + "type": "gene", + "text": "Interestingly , PKA activity is dispensable in a strain lacking Msn2p and Msn4p activity .", + "entities": [ + "PKA", + "Msn2p", + "Msn4p" + ] + }, + { + "id": "1279", + "type": "gene", + "text": "Immunoblotting of expressed recombinant proteins with the monoclonal 08L antibody localized the 08L epitope to the carboxyl end of the protein .", + "entities": [ + "monoclonal 08L antibody", + "08L" + ] + }, + { + "id": "1280", + "type": "gene", + "text": "The results indicate that anthraquinone sennoside B and rhein are weakly genotoxic .", + "entities": [] + }, + { + "id": "1281", + "type": "gene", + "text": "The medium chains of these complexes , mu1 and mu2 , have been implicated in two types of interaction : assembly with the beta1 and beta2 chains of the corresponding complexes and recognition of tyrosine - based sorting signals .", + "entities": [ + "mu1", + "mu2", + "beta1 and beta2 chains" + ] + }, + { + "id": "1282", + "type": "gene", + "text": "We conclude from this study that Arix and NBPhox exhibit indistinguishable and independent transcriptional regulatory properties on the DBH promoter .", + "entities": [ + "Arix", + "NBPhox", + "DBH promoter" + ] + }, + { + "id": "1283", + "type": "gene", + "text": "Jkappa DNA - binding sites were not required for this activation , and a mutant EBNA - 3C protein unable to bind Jkappa activated transcription as efficiently as wild - type EBNA - 3C , indicating that EBNA - 3C can regulate transcription through a mechanism that is independent of Jkappa .", + "entities": [ + "Jkappa DNA - binding sites", + "mutant EBNA - 3C protein", + "Jkappa", + "wild - type EBNA - 3C", + "EBNA - 3C", + "Jkappa" + ] + }, + { + "id": "1284", + "type": "gene", + "text": "This family of proteins binds GC - rich motifs widely distributed in gene promoters , resulting in distinct activation or repression of transcriptional activities .", + "entities": [] + }, + { + "id": "1285", + "type": "gene", + "text": "Serum IgM and IgE concentrations , allergen - specific IgE scores , and the tumor E2R status were combined to construct a three - level risk classification that was more prognostic than any of the individual components .", + "entities": [ + "Serum IgM", + "IgE", + "allergen - specific IgE", + "E2R" + ] + }, + { + "id": "1286", + "type": "gene", + "text": "Plasma was tested before and after ( 14 + / - 7 . 5 [ SD ] days ) surgery for IgG antibodies to the complex of heparin / platelet factor 4 , using a standardized , validated enzyme - linked immunosorbent assay ( ELISA ) .", + "entities": [ + "IgG antibodies", + "heparin / platelet factor 4" + ] + }, + { + "id": "1287", + "type": "gene", + "text": "A gene homologous to the Escherichia coli dnaA gene was isolated from Pseudomonas putida and its transcription was investigated in E . coli as well as in P . putida .", + "entities": [ + "Escherichia coli dnaA gene" + ] + }, + { + "id": "1288", + "type": "gene", + "text": "Because of the operon structure of this organism , traditional methods such as insertional mutagenesis run the risk of introducing polar effects on downstream genes or creating secondary mutations elsewhere in the genome .", + "entities": [] + }, + { + "id": "1289", + "type": "gene", + "text": "Our experiments suggest that the SCL gene can be a target for the erythroid transcription factor GATA - 1 and that the SCL gene product serves as a positive regulator of erythroid differentiation .", + "entities": [ + "SCL gene", + "erythroid transcription factor GATA - 1", + "SCL gene product" + ] + }, + { + "id": "1290", + "type": "gene", + "text": "As high - speed , volumetric imaging , computed tomographic scan machines such as the Dynamic Spatial Reconstructor become available with higher density resolution , perhaps a single injection of contrast agent into the right atrium or even a peripheral vein may be adequate to obtain all these measurements .", + "entities": [] + }, + { + "id": "1291", + "type": "gene", + "text": "Endogenous RMP was immunologically detected interacting with assembled RPB5 in RNA polymerase in mammalian cells .", + "entities": [ + "RMP", + "RPB5", + "RNA polymerase" + ] + }, + { + "id": "1292", + "type": "gene", + "text": "CONCLUSIONS : AMVT is rare but a potentially lethal emergency disease .", + "entities": [] + }, + { + "id": "1293", + "type": "gene", + "text": "The protein coding region , 1 , 696 bps long , is divided by an intron into two exons .", + "entities": [] + }, + { + "id": "1294", + "type": "gene", + "text": "In the mouse , CtBP1 is expressed from embryo to adult , but CtBP2 is mainly expressed during embryogenesis .", + "entities": [ + "CtBP1", + "CtBP2" + ] + }, + { + "id": "1295", + "type": "gene", + "text": "A thermal Kubo - Martin - Schwinger condition arises due to the coupling of a computer to a strong periodic source , namely , the daily and weekly usage patterns of the system .", + "entities": [] + }, + { + "id": "1296", + "type": "gene", + "text": "These characteristics indicated the pronounced activity of collagenous fiber synthesis and the matrix of the osteoid tissue .", + "entities": [] + }, + { + "id": "1297", + "type": "gene", + "text": "Mitogen - activated protein ( MAP ) kinase phosphatase - 3 ( MKP - 3 ) is a dual specificity phosphatase that inactivates extracellular signal - regulated kinase ( ERK ) MAP kinases .", + "entities": [ + "Mitogen - activated protein ( MAP ) kinase phosphatase - 3", + "MKP - 3", + "extracellular signal - regulated kinase", + "ERK", + "MAP kinases" + ] + }, + { + "id": "1298", + "type": "gene", + "text": "Fifty six young patients ( age < 45 yr ) with doppler - proven DVT were investigated for the presence of resistance to activated protein C ( APC - R ) , lupus anticoagulant ( LA ) , anticardiolipin antibodies and deficiencies of protein C , protein S , ATIII activities .", + "entities": [ + "activated protein C", + "APC - R", + "anticardiolipin antibodies", + "protein C", + "protein S", + "ATIII" + ] + }, + { + "id": "1299", + "type": "gene", + "text": "CONCLUSIONS : Congenital horizontal tarsal kink is rare and its cause is unknown .", + "entities": [] + }, + { + "id": "1300", + "type": "gene", + "text": "( 5 ) No changes were observed in the gastric venous blood flow by continuous intravenous injection of cimetidine , but by rapid injection both the flow was augmented and the systemic blood pressure decreased transiently .", + "entities": [] + }, + { + "id": "1301", + "type": "gene", + "text": "Two of these motifs are part of a highly conserved and inducible dyad symmetry element shown previously to control a remote IL - 2 enhancer and the CD18 promoter .", + "entities": [ + "IL - 2 enhancer", + "CD18 promoter" + ] + }, + { + "id": "1302", + "type": "gene", + "text": "About 20 % of single - stranded DNA binding was observed in the presence of MgdTDP , but none was detectable in the absence of nucleotides .", + "entities": [] + }, + { + "id": "1303", + "type": "gene", + "text": "Taken together , our results indicate that the FCR1 gene behaves as a negative regulator of drug resistance in C . albicans and constitute the first evidence that FCZ resistance can result from the inactivation of a regulatory factor such as Fcr1p .", + "entities": [ + "FCR1 gene", + "Fcr1p" + ] + }, + { + "id": "1304", + "type": "gene", + "text": "Using this method , we measured absorption of low doses of vitamin A , which may provide a more physiological approach to assessment of fat malabsorption .", + "entities": [] + }, + { + "id": "1305", + "type": "gene", + "text": "Magnetically induced optical self - pulsing in a nonlinear resonator .", + "entities": [] + }, + { + "id": "1306", + "type": "gene", + "text": "In the PMR target area but not in the nontreated area an improvement in regional myocardial flow reserve occurs in wall segments with initially severely or moderately reduced stress perfusion .", + "entities": [] + }, + { + "id": "1307", + "type": "gene", + "text": "Here we show that independent of uncertainties in the models , terrestrial planets with dense atmosphere like Venus can evolve into one of only four possible rotation states .", + "entities": [] + }, + { + "id": "1308", + "type": "gene", + "text": "Monotherapy with ceftazidime was clinically and bacteriologically as effective as a combination therapy with cefazolin and tobramycin .", + "entities": [] + }, + { + "id": "1309", + "type": "gene", + "text": "Radionuclide study and endomyocardial biopsy revealed remarkable degeneration of myocardium .", + "entities": [] + }, + { + "id": "1310", + "type": "gene", + "text": "The immunosuppressant FK506 inhibits amino acid import in Saccharomyces cerevisiae .", + "entities": [] + }, + { + "id": "1311", + "type": "gene", + "text": "Labial bar .", + "entities": [] + }, + { + "id": "1312", + "type": "gene", + "text": "Multivariate predictors were concentric remodeling ( P < 0 . 0001 ; odds ratio , 13 . 5 ) , left ventricular ejection fraction > 2 SD above normal ( P < 0 . 0001 ) , and single - vessel left circumflex disease ( P < 0 . 0007 ; odds ratio , 7 . 6 ) .", + "entities": [] + }, + { + "id": "1313", + "type": "gene", + "text": "W .", + "entities": [] + }, + { + "id": "1314", + "type": "gene", + "text": "Low molecular weight heparins have stimulated much interest because of their supposedly more selective action on Xa factor .", + "entities": [ + "Xa factor" + ] + }, + { + "id": "1315", + "type": "gene", + "text": "It is concluded that CT should be routinely employed in patients with N1 - N3 neck disease to determine the proper electron - energy prescription .", + "entities": [] + }, + { + "id": "1316", + "type": "gene", + "text": "Elevation of intracellular Ca ( 2 + ) levels are also involved because treatment with receptor - associated protein , nifedipine , MK801 , removal of Ca ( 2 + ) from the medium and dantrolene all served to inhibit calcium elevation and attenuate the activation of CREB .", + "entities": [ + "CREB" + ] + }, + { + "id": "1317", + "type": "gene", + "text": "Chronic E - B virus infection terminated in malignant lymphoma : a case report", + "entities": [] + }, + { + "id": "1318", + "type": "gene", + "text": "The cdr1 sequence includes an additional 237 amino acids of the contiguous fragment and encodes a product of predicted Mr 67 , 000 .", + "entities": [ + "cdr1 sequence" + ] + }, + { + "id": "1319", + "type": "gene", + "text": "In mice , three major families of L1 elements , termed \" A , \" \" F , \" and \" V , \" have been defined on the basis of the sequence found at the 5 ' terminus .", + "entities": [] + }, + { + "id": "1320", + "type": "gene", + "text": "Cloning and characterization of human Lnk , an adaptor protein with pleckstrin homology and Src homology 2 domains that can inhibit T cell activation .", + "entities": [ + "human Lnk", + "pleckstrin", + "Src homology 2 domains" + ] + }, + { + "id": "1321", + "type": "gene", + "text": "16 women were treated with methadone to prevent withdrawal symptoms .", + "entities": [] + }, + { + "id": "1322", + "type": "gene", + "text": "In the final model , grade ( p = 0 . 0002 ) , peritoneal cytologic results ( p = 0 . 0002 ) , progesterone receptor status ( p = 0 . 004 ) , and age as a continuous variable ( p = 0 . 008 ) were most closely associated with disease - free survival .", + "entities": [ + "progesterone receptor" + ] + }, + { + "id": "1323", + "type": "gene", + "text": "The cardiac myosin light chain - 2 ( MLC - 2 ) gene promoter contains several positive and negative cis - acting sequences that are involved in the regulation of its expression .", + "entities": [ + "cardiac myosin light chain - 2", + "MLC - 2" + ] + }, + { + "id": "1324", + "type": "gene", + "text": "FAK localizes to sites of transmembrane integrin receptor clustering and facilitates intracellular signaling events .", + "entities": [ + "FAK", + "transmembrane integrin receptor" + ] + }, + { + "id": "1325", + "type": "gene", + "text": "The MCA and UA PI values showed the greatest deviation for any single - vessel parameter .", + "entities": [] + }, + { + "id": "1326", + "type": "gene", + "text": "Junctions between cells of the human enamel organ .", + "entities": [] + }, + { + "id": "1327", + "type": "gene", + "text": "An endometrial luteal phase deficiency was detected in 15 ( 30 % ) of aborting patients .", + "entities": [] + }, + { + "id": "1328", + "type": "gene", + "text": "Technique for obtaining refined ceramics with dense mass", + "entities": [] + }, + { + "id": "1329", + "type": "gene", + "text": "The distribution of cryptosporidia in the intestine and number of cryptosporidia per ileal villus on different DPI were also estimated for detailed characterization of the infection in kids as a model for experimental cryptosporidiosis .", + "entities": [] + }, + { + "id": "1330", + "type": "gene", + "text": "Northern blotting analysis indicates that expression of the genes corresponding to these clones is confined to pollen tissue .", + "entities": [] + }, + { + "id": "1331", + "type": "gene", + "text": "The first contains ATF / CRE and TBP / TATA sequence motifs within an 87 - bp region .", + "entities": [ + "ATF", + "TBP" + ] + }, + { + "id": "1332", + "type": "gene", + "text": "Both pancreatic and intestinal cell lines were found to express a number of POU ( OCT binding ) homeodomain proteins examined by electrophoretic mobility shift assay .", + "entities": [ + "POU", + "OCT" + ] + }, + { + "id": "1333", + "type": "gene", + "text": "The nucleotide sequence of the chloroplast ( cp ) DNA from maize ( Zea mays ) has been completed .", + "entities": [] + }, + { + "id": "1334", + "type": "gene", + "text": "Despite the reported detrimental effects on CNS development , a number of animal studies have shown that pretreatment with corticosteroids nevertheless protect the brain from hypoxia - ischemic injury ; however , clinically such treatment is no longer favored .", + "entities": [] + }, + { + "id": "1335", + "type": "gene", + "text": "Since CENP - B gene is conserved in mammalian species and CENP - B boxes are found also in mouse centromere satellite DNA ( minor satellite ) , this sequence - specific DNA - protein interaction may be important for some kind of common centromere function .", + "entities": [ + "CENP - B gene", + "CENP - B boxes" + ] + }, + { + "id": "1336", + "type": "gene", + "text": "Electrophoretic mobility shift assays and coimmunoprecipitation studies suggest that homo - and heterodimerization occurs between cKrox family members .", + "entities": [ + "cKrox family members" + ] + }, + { + "id": "1337", + "type": "gene", + "text": "A genetic and molecular analysis of non - inducible qutA mutants showed that all 23 mutations analysed map within the N - terminal half of the encoded QUTA protein .", + "entities": [ + "qutA mutants", + "QUTA protein" + ] + }, + { + "id": "1338", + "type": "gene", + "text": "There were 27 men and 156 women .", + "entities": [] + }, + { + "id": "1339", + "type": "gene", + "text": "The individual subunits of Ku have been difficult to isolate from human cells without denaturation and attempts to produce functional recombinant Ku have been largely unsuccessful .", + "entities": [ + "Ku", + "functional recombinant Ku" + ] + }, + { + "id": "1340", + "type": "gene", + "text": "Enhancers containing disrupted Ets - 1 binding sites were tested in transient expression assays in the murine T - cell line EL4 . E1 ; alterations in the LVb element affected constitutive enhancer activity , while mutation of either the LVb or LVc element disrupted phorbol ester - induced enhancer activity .", + "entities": [ + "Ets - 1 binding sites" + ] + }, + { + "id": "1341", + "type": "gene", + "text": "Most kinases are not significantly inhibited by roscovitine .", + "entities": [] + }, + { + "id": "1342", + "type": "gene", + "text": "cdc2 / cyclin B , cdk2 / cyclin A , cdk2 / cyclin E and cdk5 / p35 only are substantially inhibited ( IC50 values of 0 . 65 , 0 . 7 , 0 . 7 and 0 . 2 microM , respectively ) .", + "entities": [ + "cdc2", + "cyclin B", + "cdk2", + "cyclin A", + "cdk2", + "cyclin E", + "cdk5", + "p35" + ] + }, + { + "id": "1343", + "type": "gene", + "text": "cdk4 / cyclin D1 and cdk6 / cyclin D2 are very poorly inhibited by roscovitine ( IC50 > 100 microM ) .", + "entities": [ + "cdk4", + "cyclin D1", + "cdk6", + "cyclin D2" + ] + }, + { + "id": "1344", + "type": "gene", + "text": "Differential drawing size associated with unilateral brain damage .", + "entities": [] + }, + { + "id": "1345", + "type": "gene", + "text": "Analyses revealed that scale matters above and beyond the effect of quadrat area .", + "entities": [] + }, + { + "id": "1346", + "type": "gene", + "text": "Consistent with this interpretation , recombinant CREB and activating transcription factor proteins bound the junB CRE - like site , but did not interact with a mutant CRE - like site .", + "entities": [ + "recombinant CREB", + "activating transcription factor proteins", + "junB" + ] + }, + { + "id": "1347", + "type": "gene", + "text": "Efforts were made to determine the amount of time required for kidney lesions to develop and , if possible , to delineate the potential site of action of PBB .", + "entities": [] + }, + { + "id": "1348", + "type": "gene", + "text": "It could also inhibit C1q - dependent haemolysis of both IgG - and IgM - sensitized erythrocytes .", + "entities": [ + "C1q", + "IgG", + "IgM" + ] + }, + { + "id": "1349", + "type": "gene", + "text": "Similar results were seen on Western blots of Autographa californica MNPV ( AcMNPV ) - infected Spodoptera frugiperda cells .", + "entities": [] + }, + { + "id": "1350", + "type": "gene", + "text": "Effects of early monocular deprivation on development of cortico - geniculate projections in the cat .", + "entities": [] + }, + { + "id": "1351", + "type": "gene", + "text": "Cochlear microphonic potentials in patients with vestibular schwannomas .", + "entities": [] + }, + { + "id": "1352", + "type": "gene", + "text": "Snail family proteins are zinc finger transcriptional regulators first identified in Drosophila which play critical roles in cell fate determination .", + "entities": [ + "Snail family proteins" + ] + }, + { + "id": "1353", + "type": "gene", + "text": "In diethyl ether solution the main peak is that of 2 - benzylidenamio - 1 - phenylpropane , which has a retention time of 23 , 2 minutes under the condition delineated .", + "entities": [] + }, + { + "id": "1354", + "type": "gene", + "text": "Pol32Delta strains are weak antimutators and are defective for damage - induced mutagenesis .", + "entities": [ + "Pol32Delta" + ] + }, + { + "id": "1355", + "type": "gene", + "text": "RESULTS : Closure time of fistulas in patients receiving TPN + somatostatin was significantly shorter ( 13 . 86 + / - 1 . 84 versus 20 . 4 + / - 2 . 89 days ) than in those receiving TPN alone .", + "entities": [ + "somatostatin" + ] + }, + { + "id": "1356", + "type": "gene", + "text": "The effect of lithium on the osmoregulation of arginine vasopressin secretion .", + "entities": [ + "arginine vasopressin" + ] + }, + { + "id": "1357", + "type": "gene", + "text": "Paul Monagle addresses the epidemiology of neonatal thrombosis outside of the central nervous system in both arterial and venous locations , and those that occur in utero .", + "entities": [] + }, + { + "id": "1358", + "type": "gene", + "text": "Again residue Glu - 381 of beta was notably reduced and no missing residue from the epsilon peptide could be identified , but the peptide sequence limited the possible choices to Ser - 106 , Ser - 107 , or Ser - 108 .", + "entities": [] + }, + { + "id": "1359", + "type": "gene", + "text": "Ventral rhinotomy is no more difficult than dorsal rhinotomy , has less patient morbidity and fewer postoperative complications , and is more cosmetically acceptable .", + "entities": [] + }, + { + "id": "1360", + "type": "gene", + "text": "After resection of the proximal fragment , all scaphoid contact area and pressure was born by the distal scaphoid fragment .", + "entities": [] + }, + { + "id": "1361", + "type": "gene", + "text": "The results presented here show that AR1 of the promoter - proximal CAP subunit was required for papBA transcription even in the absence of the histone - like protein H - NS .", + "entities": [ + "AR1", + "CAP subunit", + "papBA", + "H - NS" + ] + }, + { + "id": "1362", + "type": "gene", + "text": "Approximately 50 % of the residues are conserved among all three sequences , yet all three viruses have retained response elements for glucocorticoids , two positionally conserved CCAAT boxes , and positionally conserved TATA boxes .", + "entities": [] + }, + { + "id": "1363", + "type": "gene", + "text": "Electrophile Response Elements ( EpREs ) , located in 5 ' - flanking sequences of both the GCSh and GCSl subunit genes , are hypothesized to at least partially mediate gene induction following xenobiotic exposure .", + "entities": [ + "GCSh", + "GCSl subunit genes" + ] + }, + { + "id": "1364", + "type": "gene", + "text": "As demonstrated by gel mobility shift analysis and supershift experiments , FIRE1 , located between - 516 and - 498 , is responsible for binding NF - Y .", + "entities": [ + "FIRE1", + "NF - Y" + ] + }, + { + "id": "1365", + "type": "gene", + "text": "Aviators from the Light Attack Wing , Pacific were surveyed and the results were categorized by aircraft type .", + "entities": [] + }, + { + "id": "1366", + "type": "gene", + "text": "Nonlocal approach to scattering in a one - dimensional problem .", + "entities": [] + }, + { + "id": "1367", + "type": "gene", + "text": "Although the risk of malformation in children born after ICSI is not increased there is an increased risk to transmit genetic abnormalities in case of NOA ( such as the rate of sex chromosome , or microdeletions of the Y chromosome ) and in case of congenital OA ( mutations of the cystic fibrosis gene ) .", + "entities": [ + "cystic fibrosis gene" + ] + }, + { + "id": "1368", + "type": "gene", + "text": "Several demographic indices of isolated populations in Uzbekistan", + "entities": [] + }, + { + "id": "1369", + "type": "gene", + "text": "METHODS : Between August 1991 and June 1994 , 198 men with clinical T2 or T3 classified ( TNM ) prostate carcinoma ( bone scan negative ) who were at high risk of lymph node involvement underwent a 111In - capromab pendetide scan prior to staging lymphadenectomy .", + "entities": [] + }, + { + "id": "1370", + "type": "gene", + "text": "The sera and nasal secretions of 142 patients , who were positive in HD or mites skin test , were subjected to a radioallergosorbent test ( RAST ) for estimating the specific IgE antibody activity to mites .", + "entities": [ + "IgE antibody" + ] + }, + { + "id": "1371", + "type": "gene", + "text": "Group 6 was given physostigmine , 0 . 1 mg / kg i . v . , known to inhibit cholinesterase degradation , 5 min before bupivacaine administration , and Group 7 received a combination of physostigmine pretreatment and electrical vagal stimulation .", + "entities": [ + "cholinesterase" + ] + }, + { + "id": "1372", + "type": "gene", + "text": "IRF - 1 acts as a transcriptional activator , while IRF - 2 acts as a repressor .", + "entities": [ + "IRF - 1", + "IRF - 2" + ] + }, + { + "id": "1373", + "type": "gene", + "text": "A single case of an adenocarcinoma , arising in a retroperitoneal enterogenous cyst and which presented as a left renal cyst , is reported .", + "entities": [] + }, + { + "id": "1374", + "type": "gene", + "text": "This 5 ' splice site sequence was required for enhanced polyadenylation and was recognized by both U1 small nuclear ribonucleoproteins ( snRNPs ) and alternative splicing factor / splicing factor 2 ( ASF / SF2 ) .", + "entities": [ + "U1 small nuclear ribonucleoproteins", + "alternative splicing factor", + "splicing factor 2", + "ASF", + "SF2" + ] + }, + { + "id": "1375", + "type": "gene", + "text": "Tests of the method indicate ( 1 ) the Mossbauer source can be placed on the basilar membrane without altering the signal - transmission properties of the cochlea , and ( 2 ) the source adheres to the basilar membrane .", + "entities": [] + }, + { + "id": "1376", + "type": "gene", + "text": "Copyright 1998 Academic Press .", + "entities": [] + }, + { + "id": "1377", + "type": "gene", + "text": "Marker rescue analysis has localized ts8 to a 910 - bp internal segment of rpoB that encodes the Rif domain .", + "entities": [ + "ts8", + "rpoB", + "Rif domain" + ] + }, + { + "id": "1378", + "type": "gene", + "text": "Children with defective vision", + "entities": [] + }, + { + "id": "1379", + "type": "gene", + "text": "Dementia is being avoided in NHS and social care .", + "entities": [] + }, + { + "id": "1380", + "type": "gene", + "text": "Neither verapamil nor nifedipine changed collateral myocardial blood flow from 0 . 10 + / - 0 . 02 in the subendocardium and 0 . 17 + / - 0 . 03 ml / min / g in the subepicardium .", + "entities": [] + }, + { + "id": "1381", + "type": "gene", + "text": "In vitro translation experiments show that human cDNA derived RNA translates into a protein with a mobility of 44 - 46 kD on SDS polyacrylamide gels .", + "entities": [] + }, + { + "id": "1382", + "type": "gene", + "text": "One hundred replicate data sets of 100 subjects each were simulated for each missing data scenario .", + "entities": [] + }, + { + "id": "1383", + "type": "gene", + "text": "Folate metabolism in the human malaria parasite Plasmodium falciparum is an essential activity for cell growth and replication , and the target of an important class of therapeutic agents in widespread use .", + "entities": [] + }, + { + "id": "1384", + "type": "gene", + "text": "For these patients the introduction of a separate category \" extended oligoarthritis at onset \" should be considered to establish comparable patient groups .", + "entities": [] + }, + { + "id": "1385", + "type": "gene", + "text": "Polysome analysis further indicated that these germ cell - specific Sp1 mRNAs are translated , albeit with a lower efficiency than the somatic transcript .", + "entities": [ + "germ cell - specific Sp1 mRNAs" + ] + }, + { + "id": "1386", + "type": "gene", + "text": "YAC and cosmid contigs spanning the BRCA1 region were used to select cDNA clones from pools of cDNAs derived from human placenta , HeLa cells , activated T cells , and fetal head .", + "entities": [ + "BRCA1 region" + ] + }, + { + "id": "1387", + "type": "gene", + "text": "A soluble 62 - kDa protein was produced without the proteolytic processing by inserting the coding sequence of amino acids 112 to 660 of ORF - 2 in a baculovirus expression vector and using the corresponding virus to infect Sf9 cells .", + "entities": [] + }, + { + "id": "1388", + "type": "gene", + "text": "In rats anaesthetized with + - chloralose the changes in extracellular pH and K + in spinal cord dorsal horn were studied using pH and K + ion - selective electrodes .", + "entities": [] + }, + { + "id": "1389", + "type": "gene", + "text": "Human AP - 2rep repressed both reporter expression from a transiently transfected AP - 2alpha promoter and the endogenous AP - 2alpha gene and inversely was negatively regulated by AP - 2alpha .", + "entities": [ + "Human AP - 2rep", + "AP - 2alpha promoter", + "AP - 2alpha gene", + "AP - 2alpha" + ] + }, + { + "id": "1390", + "type": "gene", + "text": "The presence of circulating platelet aggregates and elevated levels of fibrinopeptide A ( a cleavage product of fibrin ) suggests that platelet activation and fibrin deposition may play a role in the pathogenesis of this disorder .", + "entities": [ + "fibrinopeptide A", + "fibrin", + "fibrin" + ] + }, + { + "id": "1391", + "type": "gene", + "text": "Because the adrenergic nervous system influences cardiac arrhythmias and myocardial infarction can directly affect sympathetic innervation in the heart , we investigated the role of the sympathetic nervous system on reentry in the canine heart 4 days after infarction .", + "entities": [] + }, + { + "id": "1392", + "type": "gene", + "text": "They have not been previously reported as a reaction to i . v . contrast material .", + "entities": [] + }, + { + "id": "1393", + "type": "gene", + "text": "A 1 - base pair mismatch within the corresponding region of the CYP3A4 gene was sufficient for a differential enhancer activity .", + "entities": [ + "CYP3A4 gene" + ] + }, + { + "id": "1394", + "type": "gene", + "text": "In addition , stonin 2 binds to the C2B domains of synaptotagmins I and II .", + "entities": [ + "stonin 2", + "synaptotagmins I and II" + ] + }, + { + "id": "1395", + "type": "gene", + "text": "On the role of transferrin in the uptake of gallium by tumor cells .", + "entities": [ + "transferrin" + ] + }, + { + "id": "1396", + "type": "gene", + "text": "Laboratory studies using Ca45 labeled teeth and biologically stained teeth confirmed that the dentifrice did not decalcify enamel or bleach teeth .", + "entities": [] + }, + { + "id": "1397", + "type": "gene", + "text": "The yeast RER2 gene , identified by endoplasmic reticulum protein localization mutations , encodes cis - prenyltransferase , a key enzyme in dolichol synthesis .", + "entities": [ + "yeast RER2 gene", + "cis - prenyltransferase" + ] + }, + { + "id": "1398", + "type": "gene", + "text": "The serine / threonine kinase Raf - 1 functions downstream of Rats in a signal transduction cascade which transmits mitogenic stimuli from the plasma membrane to the nucleus .", + "entities": [ + "Raf - 1", + "Rats" + ] + }, + { + "id": "1399", + "type": "gene", + "text": "The survival in the case of these patients was studied five years later .", + "entities": [] + }, + { + "id": "1400", + "type": "gene", + "text": "In contrast , the insulin response had returned to the non - pregnant value by the second day of the puerperium .", + "entities": [ + "insulin" + ] + }, + { + "id": "1401", + "type": "gene", + "text": "These data strongly implicate the normal product of the int - 2 gene , which is related to the fibroblast growth factor family , as a contributory factor in virally induced mammary tumors .", + "entities": [ + "int - 2 gene", + "fibroblast growth factor family" + ] + }, + { + "id": "1402", + "type": "gene", + "text": "The combination of Pitx2 and another homeodomain protein , Pit - 1 , yielded a synergistic 55 - fold activation of the prolactin promoter in transfection assays .", + "entities": [ + "Pitx2", + "homeodomain protein", + "Pit - 1", + "prolactin promoter" + ] + }, + { + "id": "1403", + "type": "gene", + "text": "Reaction of human organism to exercise .", + "entities": [] + }, + { + "id": "1404", + "type": "gene", + "text": "PhoP - PhoQ homologues in Pseudomonas aeruginosa regulate expression of the outer - membrane protein OprH and polymyxin B resistance .", + "entities": [ + "PhoP", + "PhoQ", + "outer - membrane protein OprH" + ] + }, + { + "id": "1405", + "type": "gene", + "text": "By using a DNA sequence selected for its ability to bind recombinant BCL - 6 in vitro , we show here that BCL - 6 is present in DNA - binding complexes in nuclear extracts from various B - cell lines .", + "entities": [ + "recombinant BCL - 6", + "BCL - 6" + ] + }, + { + "id": "1406", + "type": "gene", + "text": "These studies have shown that the majority of tested staphylococci were resistant to penicillin G , erythromycin , and produced beta - lactamase .", + "entities": [ + "beta - lactamase" + ] + }, + { + "id": "1407", + "type": "gene", + "text": "Analysis of Msy2 mRNA expression in prepubertal and adult mouse testes , and in isolated populations of germ cells , reveals maximal expression in postmeiotic round spermatids , a cell type with abundant amounts of stored messenger ribonucleoproteins .", + "entities": [ + "Msy2 mRNA" + ] + }, + { + "id": "1408", + "type": "gene", + "text": "Radiolabeled biantennary N - glycans synthesized by Pro ( - ) 5Lec20 were proportionately less ricin - bound than similar species from parental CHO cells , and Lec20 cell extracts had a markedly reduced ability to transfer Gal to GlcNAc - terminating acceptors .", + "entities": [] + }, + { + "id": "1409", + "type": "gene", + "text": "The C - terminal region contains the PTP - like domain , whereas the N - terminal region shows no homology to any known mammalian protein .", + "entities": [ + "PTP - like domain" + ] + }, + { + "id": "1410", + "type": "gene", + "text": "These equilibrium solutions are then shown to arise from the vertices of a particular convex polyhedron .", + "entities": [] + }, + { + "id": "1411", + "type": "gene", + "text": "Co - transfection of the Sp1 expression plasmid and the - 58 promoter construct into Drosophila Schneider cells revealed that Sp1 contributed to the kinase basal promoter activity by binding to the non - consensus site in the - 58 region .", + "entities": [ + "Sp1", + "Sp1" + ] + }, + { + "id": "1412", + "type": "gene", + "text": "Several agents have been tried for treatment , often limited by toxic side effects .", + "entities": [] + }, + { + "id": "1413", + "type": "gene", + "text": "To study the origin of different fMLF - R transcripts , the genetic linkage of chemotactic receptor genes , and the regulation of fMLF - R gene expression , we determined the copy number , chromosomal location , structural organization , and 5 ' - flanking sequence of the human fMLF - R gene .", + "entities": [ + "fMLF - R transcripts", + "fMLF - R gene", + "human fMLF - R gene" + ] + }, + { + "id": "1414", + "type": "gene", + "text": "In the next week , the beta - adrenergic antagonist atenolol was added at an initial dose of 25 mg / day and titrated to 50 mg / day within 1 week .", + "entities": [] + }, + { + "id": "1415", + "type": "gene", + "text": "Three group 1 patients developed CMV disease ; 1 group 2 patient developed CMV hepatitis .", + "entities": [] + }, + { + "id": "1416", + "type": "gene", + "text": "Neomycin is fairly effective against staphylococci , less effective against streptococci , and fairly effective against gram - negative intestinal organisms .", + "entities": [] + }, + { + "id": "1417", + "type": "gene", + "text": "49 , XXXXY chromosome anomaly : an unusual variant of Klinefelter ' s syndrome .", + "entities": [] + }, + { + "id": "1418", + "type": "gene", + "text": "Plate luting , a technique that uses polymethylmethacrylate ( PMMA ) interposed between the plate and the bone , as well as between the screw heads and the plate , to improve the stability of internal fixation was tested in vitro using 20 paired equine third metacarpal bones with mid - diaphyseal osteotomies plated with six - hole broad ASIF compression plates .", + "entities": [] + }, + { + "id": "1419", + "type": "gene", + "text": "Epidemiological data are quite controversial but sudden death occurring during sporting activity is probably not a rare occurrence .", + "entities": [] + }, + { + "id": "1420", + "type": "gene", + "text": "Therapeutic action of a new antibiotic - corticoid association used for instillations in otology", + "entities": [] + }, + { + "id": "1421", + "type": "gene", + "text": "Temperature dependence of the sublattice spontaneous magnetization of YBa2Cu3O6 .", + "entities": [] + }, + { + "id": "1422", + "type": "gene", + "text": "Hypoglycemic action of \" he xiang zhuang qi gong \" and its mechanism on diabetes mellitus", + "entities": [] + }, + { + "id": "1423", + "type": "gene", + "text": "The five - drug combination of fluorouracil imidazole carboxamide dimethyl triazeno , vincristine , bis - chloroethyl nitrosourea , and prednisone ( FIVB + P ) was given to 120 women with metastatic breast cancer .", + "entities": [] + }, + { + "id": "1424", + "type": "gene", + "text": "A multivariate analysis of risk factors for relapse examined age , WBC at diagnosis , blast count at diagnosis , percentage of marrow blasts , FAB subtype , the number of remission induction courses to achieve a remission , maintenance therapy , consolidation therapy , marrow cell dose , donor - recipient sex , GVHD prophylaxis regimen and isolation and decontamination in laminar airflow rooms .", + "entities": [ + "FAB" + ] + }, + { + "id": "1425", + "type": "gene", + "text": "Rolandic spikes and cognitive function .", + "entities": [] + }, + { + "id": "1426", + "type": "gene", + "text": "We show that a protein , UBC9 , interacts specifically with TEL in vitro and in vivo .", + "entities": [ + "UBC9", + "TEL" + ] + }, + { + "id": "1427", + "type": "gene", + "text": "4 .", + "entities": [] + }, + { + "id": "1428", + "type": "gene", + "text": "With respect to effective diffusivity of platelets ( De ) and the surface reactivity constant ( K ) , less significant differences were found among artificial materials .", + "entities": [] + }, + { + "id": "1429", + "type": "gene", + "text": "The GALT - primed calves had increased serum IgG , lavage IgG and IgA and increased LNA titers in both lavage fluids and serum following the SC dose of killed bacteria .", + "entities": [ + "IgG", + "IgG", + "IgA", + "LNA" + ] + }, + { + "id": "1430", + "type": "gene", + "text": "For the present work we used water saturated with a 50 / 50 mixture of H2 and O2 gases , for which the heat defect is calculated to be - 2 . 1 % .", + "entities": [] + }, + { + "id": "1431", + "type": "gene", + "text": "Chaperones / HSPs thus play important roles within cell cycle processes .", + "entities": [ + "HSPs" + ] + }, + { + "id": "1432", + "type": "gene", + "text": "No direct repeats flank the pseudogene in the U2 / 4 locus .", + "entities": [ + "U2 / 4 locus" + ] + }, + { + "id": "1433", + "type": "gene", + "text": "CONCLUSION ( S ) : Measuring urinary LH levels is an excellent method for determining ovulation .", + "entities": [ + "LH" + ] + }, + { + "id": "1434", + "type": "gene", + "text": "The major phenotypes resulting from Fab1p kinase inactivation include temperature - sensitive growth , vacuolar acidification defects , and dramatic increases in vacuolar size .", + "entities": [ + "Fab1p kinase" + ] + }, + { + "id": "1435", + "type": "gene", + "text": "In flies , the dShc protein physically associates with the activated Drosophila epidermal growth factor receptor homolog ( DER ) and is inducibly phosphorylated on tyrosine by DER .", + "entities": [ + "dShc protein", + "Drosophila epidermal growth factor receptor homolog", + "DER", + "DER" + ] + }, + { + "id": "1436", + "type": "gene", + "text": "Constitutive activation of Rac1 and RhoA causes tumorigenic transformation of NIH 3T3 cells , and their functions may be required for full Ras transformation .", + "entities": [ + "Rac1", + "RhoA", + "Ras" + ] + }, + { + "id": "1437", + "type": "gene", + "text": "The extraction measurements were used to test for extracerebral contamination of venous outflow .", + "entities": [] + }, + { + "id": "1438", + "type": "gene", + "text": "In addition , the acetyltransferase activity of p300 was observed to be distinct from the broadly essential activation function of the CH3 domain / E1A - binding region .", + "entities": [ + "p300", + "CH3 domain", + "E1A" + ] + }, + { + "id": "1439", + "type": "gene", + "text": "The 5 ' end of the genomic RNA of rubella virus ( RUB ) contains a 14 - nucleotide ( nt ) single - stranded leader ( ss - leader ) followed by a stem - and - loop structure [ 5 ' ( + ) SL ] ( nt 15 to 65 ) , the complement of which at the 3 ' end of the minus - strand RNA [ 3 ' ( - ) SL ] has been proposed to function as a promoter for synthesis of genomic plus strands .", + "entities": [] + }, + { + "id": "1440", + "type": "gene", + "text": "After profound normovolemic hemodilution ( Hct 9 % ) superiority of LV MC and LV diastolic properties was found , when myocardial oxygenation was supported by i . v . perflubron emulsion , a temporary O2 carrier .", + "entities": [] + }, + { + "id": "1441", + "type": "gene", + "text": "The entire human teneurin - 1 ( TEN1 ) gene is contained in eight PAC clones representing part of the chromosomal locus Xq25 .", + "entities": [ + "human teneurin - 1", + "TEN1" + ] + }, + { + "id": "1442", + "type": "gene", + "text": "Marrow cell necrosis in anorexia nervosa and involuntary starvation .", + "entities": [] + }, + { + "id": "1443", + "type": "gene", + "text": "End points measured were perioperative ( 30 - day ) myocardial infarction ( MI ) rate and death .", + "entities": [] + }, + { + "id": "1444", + "type": "gene", + "text": "Elevated expression of a previously uncharacterized gene , SPP381 , efficiently suppresses the growth and splicing defects of a temperature - sensitive ( Ts ) mutant prp38 - 1 .", + "entities": [ + "SPP381", + "mutant prp38 - 1" + ] + }, + { + "id": "1445", + "type": "gene", + "text": "One member of this family , RFX1 , is a transcription factor for a variety of viral and cellular genes .", + "entities": [ + "RFX1" + ] + }, + { + "id": "1446", + "type": "gene", + "text": "On the other side , when the aortic ring was perfused with L - NNA ( NO - synthesis inhibitor ) or methylene blue ( soluble cGMPase inhibitor ) , the changes could be attenuated .", + "entities": [ + "cGMPase" + ] + }, + { + "id": "1447", + "type": "gene", + "text": "However , the range of values observed is suggestive of the need to investigate districts with contrasting values of SYPLR with respect to the inter - relationships between sociodemographic characteristics , duration of symptoms , clinical presentation and treatment efficacy .", + "entities": [] + }, + { + "id": "1448", + "type": "gene", + "text": "Before birth , there were a few perivascular adrenergic nerves and correspondingly low ovarian NE levels .", + "entities": [] + }, + { + "id": "1449", + "type": "gene", + "text": "The catalytic site has an S1 pocket lined with conserved hydrophobic residues to accommodate the pyroglutamyl residue .", + "entities": [] + }, + { + "id": "1450", + "type": "gene", + "text": "The C - terminal mutants were strongly dominant over TraR , suggesting that they can form heteromultimers with the wild - type activator .", + "entities": [ + "TraR" + ] + }, + { + "id": "1451", + "type": "gene", + "text": "Group I comprised 5 adult Collies that received at least 400 microg / kg ivermectin p . o . and were presented to the VMTH 3 hours after intoxication .", + "entities": [] + }, + { + "id": "1452", + "type": "gene", + "text": "CONCLUSION : This retrospective analysis does not confirm the efficacy of one course of simultaneous Mitomycin - C and 5 - fluorouracil , at least in association with full - dose radiotherapy incorporating Iridium - 192 boost .", + "entities": [] + }, + { + "id": "1453", + "type": "gene", + "text": "Antithrombin III ( AT III ) is a plasma protein which acts as the principal inhibitor of thrombin and is a major modulator of intravascular coagulation .", + "entities": [ + "Antithrombin III", + "AT III", + "thrombin" + ] + }, + { + "id": "1454", + "type": "gene", + "text": "Characterization of CR1 repeat random PCR markers for mapping the chicken genome .", + "entities": [ + "CR1" + ] + }, + { + "id": "1455", + "type": "gene", + "text": "Here we show that the type of tyrosine kinase receptor stimulated also participates in the nature of the cAMP effect .", + "entities": [ + "tyrosine kinase receptor" + ] + }, + { + "id": "1456", + "type": "gene", + "text": "Thus , although multiple senescence pathways are activated in response to a ras oncogene , inactivation of TGFbeta1 secretion or response is sufficient to block the senescence program .", + "entities": [ + "ras oncogene", + "TGFbeta1" + ] + }, + { + "id": "1457", + "type": "gene", + "text": "We have found that PEA2 is also required for the bipolar budding pattern and that it encodes a novel protein with a predicted coiled - coil domain .", + "entities": [ + "PEA2" + ] + }, + { + "id": "1458", + "type": "gene", + "text": "The progression of non - A , non - B hepatitis to chronic diseases , and the transformation to hepatocellular carcinoma", + "entities": [] + }, + { + "id": "1459", + "type": "gene", + "text": "Fas has been shown to require ICE ( interleukin - 1 beta - converting enzyme ) family proteases to induce apoptosis from studies utilizing the cowpox ICE inhibitor protein CrmA , the synthetic tetrapeptide ICE inhibitor YVAD - CMK , and the tripeptide pan - ICE inhibitor Z - VAD - FMK .", + "entities": [ + "Fas", + "ICE", + "interleukin - 1 beta - converting enzyme", + "CrmA", + "ICE", + "YVAD - CMK", + "ICE", + "Z - VAD - FMK" + ] + }, + { + "id": "1460", + "type": "gene", + "text": "Optima ) genomic library by hybridizing with elicitor - induced stilbene synthase cDNA as a probe .", + "entities": [ + "stilbene synthase cDNA" + ] + }, + { + "id": "1461", + "type": "gene", + "text": "In this study we have introduced mutations into the corresponding elements of two cox3 promoters and show that while the core element is essential for cox3 promoter activity , upstream element mutations have little or no effect .", + "entities": [ + "cox3 promoters", + "cox3 promoter" + ] + }, + { + "id": "1462", + "type": "gene", + "text": "Nursing education - - the computer obligation .", + "entities": [] + }, + { + "id": "1463", + "type": "gene", + "text": "Mycotoxins in feeds and foods .", + "entities": [] + }, + { + "id": "1464", + "type": "gene", + "text": "The treatment group also showed in vivo T - cell activation with an initial lymphopenia followed by a rebound lymphocytosis and upregulation of the subset markers CD25 ( interleukin 2 receptor ) and CD45RO ( T - memory cells ) .", + "entities": [ + "CD25", + "interleukin 2 receptor", + "CD45RO" + ] + }, + { + "id": "1465", + "type": "gene", + "text": "The first gene codes for a protein containing 11 cystein residues in an arrangement typical for Fe / S proteins .", + "entities": [ + "Fe / S proteins" + ] + }, + { + "id": "1466", + "type": "gene", + "text": "The rear silver liquid chamber was threefold thick to 17 MeV protons in water and it efficiently produced either 13N by the 16O ( p , alpha ) 13N reaction or [ 18F ] fluoride ion by the 18O ( p , n ) 18F reaction .", + "entities": [] + }, + { + "id": "1467", + "type": "gene", + "text": "Sleep was determined again for an additional 3 days and 6 hours .", + "entities": [] + }, + { + "id": "1468", + "type": "gene", + "text": "Investigation of the control of coronavirus subgenomic mRNA transcription by using T7 - generated negative - sense RNA transcripts .", + "entities": [] + }, + { + "id": "1469", + "type": "gene", + "text": "Perilunar luxation - - an unusual injury demanding immediate and correct treatment", + "entities": [] + }, + { + "id": "1470", + "type": "gene", + "text": "In the present study , we identified a strong positive cis - regulatory element at - 70 bp to - 75 bp in the LpS1 beta promoter with the sequence ( G ) 6 and a similar , more distal cis - element at - 721 bp to - 726 bp .", + "entities": [ + "LpS1 beta promoter" + ] + }, + { + "id": "1471", + "type": "gene", + "text": "Relaxation of catch in a molluscan smooth muscle .", + "entities": [] + }, + { + "id": "1472", + "type": "gene", + "text": "We identified a protein , termed NFIL - 1 beta A ( NF beta A ) , that binds to a highly conserved 12 - bp DNA sequence ( - 49 to - 38 ) located upstream of the TATA box motif in both the human and murine IL - 1 beta genes .", + "entities": [ + "NFIL - 1 beta A", + "NF beta A", + "human and murine IL - 1 beta genes" + ] + }, + { + "id": "1473", + "type": "gene", + "text": "Saturable spermidine transport in stk2 : : lacZ mutants had an approximately fivefold - lower affinity and twofold - lower Vmax than in the parental strain .", + "entities": [ + "stk2", + "lacZ mutants" + ] + }, + { + "id": "1474", + "type": "gene", + "text": "We show here that v - Rel specifically increased expression from a reporter plasmid containing multiple Sp1 binding sites approximately sixfold in chicken embryo fibroblasts ( CEFs ) , even though v - Rel did not bind directly to these sites .", + "entities": [ + "v - Rel", + "Sp1 binding sites", + "v - Rel" + ] + }, + { + "id": "1475", + "type": "gene", + "text": "v - Rel also increased expression from a reporter plasmid containing a human immunodeficiency virus type 1 ( HIV - 1 ) long terminal repeat ( LTR ) in which the kappa B binding sites were mutated but which still contained intact Sp1 binding sites .", + "entities": [ + "v - Rel", + "human immunodeficiency virus type 1 ( HIV - 1 ) long terminal repeat", + "kappa B binding sites", + "Sp1 binding sites" + ] + }, + { + "id": "1476", + "type": "gene", + "text": "Sixteen patients were studied within 24 hours of resuscitation and all showed depressed right ventricular ejection ( RVEF ) and / or an increased end - diastolic volume ( RVEDVI ) .", + "entities": [] + }, + { + "id": "1477", + "type": "gene", + "text": "Here we review progress to date in this area .", + "entities": [] + }, + { + "id": "1478", + "type": "gene", + "text": "DPA attenuated the increase of the intensity of the ischemic and pressure pain components with increasing ischemia duration , but only the effect on the pressure pain component was significant .", + "entities": [] + }, + { + "id": "1479", + "type": "gene", + "text": "The S229A variant can better flip modified bases but does not tightly lock the flipped base into the adenine - binding pocket , suggesting that Ser229 could form a contact to the flipped adenine .", + "entities": [] + }, + { + "id": "1480", + "type": "gene", + "text": "Therefore the prevalences of total diabetes and GDM were 1 . 19 % and 0 . 56 % , respectively .", + "entities": [] + }, + { + "id": "1481", + "type": "gene", + "text": "Thus , this study provides evidence that a novel , ubiquitous factor ( HF - 1a ) and a muscle factor ( HF - 1b / MEF - 2 ) can form a novel , E - box - independent pathway for muscle - specific expression in ventricular cardiac muscle cells .", + "entities": [ + "HF - 1a", + "HF - 1b", + "MEF - 2" + ] + }, + { + "id": "1482", + "type": "gene", + "text": "Magnetic resonance imaging ( MRI ) has enabled us to see the spinal intramedullary pathology as differences in signal intensity .", + "entities": [] + }, + { + "id": "1483", + "type": "gene", + "text": "As with the heterologous DNA binding domain , MZF - 1 represses reporter gene expression in nonhematopoietic cell lines and activates expression in hematopoietic cell lines .", + "entities": [ + "MZF - 1" + ] + }, + { + "id": "1484", + "type": "gene", + "text": "Chinese Spring ( CS ) carrying the Q gene to those of a chromosome deletion line of CS , namely , q5 , which lacks 15 % of 5AL including the Q gene .", + "entities": [ + "Q gene", + "Q gene" + ] + }, + { + "id": "1485", + "type": "gene", + "text": "Histochemical localization of GUS revealed promoter function in leaf epidermis , mesophyll and vascular bundles , in the cortex and vascular cylinder of the root .", + "entities": [ + "GUS" + ] + }, + { + "id": "1486", + "type": "gene", + "text": "Yeast U1 snRNP is considerably more complex than its metazoan counterpart , which suggests possible differences between yeast and metazoa in early splicing events .", + "entities": [ + "Yeast U1 snRNP" + ] + }, + { + "id": "1487", + "type": "gene", + "text": "Although a carboxyl - terminal HSF transcriptional activation domain is critical for the activation of CUP1 transcription in response to both heat shock stress and glucose starvation , this region is dispensable for transient heat shock activation of at least two genes encoding members of the S . cerevisiae hsp70 family .", + "entities": [ + "HSF", + "CUP1", + "hsp70 family" + ] + }, + { + "id": "1488", + "type": "gene", + "text": "Developmental toxicity of the class III antiarrhythmic agent almokalant in mice .", + "entities": [] + }, + { + "id": "1489", + "type": "gene", + "text": "When the CO2 content reached 9 Vol % the animals became apathic and lost body weight .", + "entities": [] + }, + { + "id": "1490", + "type": "gene", + "text": "The tissue specificity of gene expression was identical to that described previously for the CaMV 35S domain B enhancer element .", + "entities": [ + "CaMV 35S domain B enhancer element" + ] + }, + { + "id": "1491", + "type": "gene", + "text": "Cardiac endothelin release and infarct size , myocardial blood flow , and ventricular function in canine infarction and reperfusion .", + "entities": [ + "Cardiac endothelin" + ] + }, + { + "id": "1492", + "type": "gene", + "text": "The relationship between primary malignant lymphoma of the thyroid and chronic thyroiditis is discussed .", + "entities": [] + }, + { + "id": "1493", + "type": "gene", + "text": "In biopsies CK - MB fraction of total myocardial CPK was 37 % , the total - CPK activity of human skeletal muscles still shows a 5 % fraction of CK - MB .", + "entities": [ + "CK - MB", + "CPK", + "total - CPK", + "CK - MB" + ] + }, + { + "id": "1494", + "type": "gene", + "text": "The primers were degenerate sets of oligonucleotides derived from known amino acid sequences of the PBAN precursor .", + "entities": [ + "PBAN precursor" + ] + }, + { + "id": "1495", + "type": "gene", + "text": "Trypanosoma cruzi .", + "entities": [] + }, + { + "id": "1496", + "type": "gene", + "text": "These mutants had deletions of the extreme amino - terminal residues as far as amino acid residue 30 .", + "entities": [] + }, + { + "id": "1497", + "type": "gene", + "text": "QBMDs for a 5 % change in response ( QBMD05 ) were 6 - fold lower , on average , than the corresponding NOAEL .", + "entities": [] + }, + { + "id": "1498", + "type": "gene", + "text": "BACKGROUND : Gamma knife radiosurgery ( GKR ) is a safe and effective alternative to surgery for intracranial lesions .", + "entities": [] + }, + { + "id": "1499", + "type": "gene", + "text": "Serum leptin concentrations in women during gonadotropin stimulation cycles .", + "entities": [ + "leptin", + "gonadotropin" + ] + }, + { + "id": "1500", + "type": "gene", + "text": "C / EBP beta V > A selectively binds only the subset of C / EBP sites that are also DBP sites , both as oligonucleotides and within the natural contexts of the albumin and cholesterol hydroxylase promoters .", + "entities": [ + "C / EBP beta V", + "C / EBP sites", + "DBP sites", + "albumin", + "cholesterol hydroxylase promoters" + ] + }, + { + "id": "1501", + "type": "gene", + "text": "During the last 6 months of the study a striking change in epidemiology concerning hepatitis A was seen , apparently caused by a steep increase in the incidence of this type of hepatitis among drug addicts .", + "entities": [] + }, + { + "id": "1502", + "type": "gene", + "text": "In 11 eyes that had been selected at random 10 micrograms of recombinant tissue plasminogen activator were injected midvitreally 24 hrs later .", + "entities": [ + "recombinant tissue plasminogen activator" + ] + }, + { + "id": "1503", + "type": "gene", + "text": "Total body irradiation was delivered according to a hyperfractionated scheme of 12 fractions given three per day 5 hr apart for 4 days .", + "entities": [] + }, + { + "id": "1504", + "type": "gene", + "text": "Femoral strain adaptation after total hip replacement : a comparison of cemented and porous ingrowth components in canines .", + "entities": [] + }, + { + "id": "1505", + "type": "gene", + "text": "In addition to the protein - tyrosine kinase domain , p56lck possesses Src homology 2 and 3 ( SH2 and SH3 ) domains as well as a unique N - terminal region .", + "entities": [ + "protein - tyrosine kinase domain", + "p56lck", + "Src homology 2 and 3", + "SH2", + "SH3" + ] + }, + { + "id": "1506", + "type": "gene", + "text": "Relationships with the acquired immune deficiency syndrome .", + "entities": [] + }, + { + "id": "1507", + "type": "gene", + "text": "The determination of the double bounds in blood serum lipids by titration with ozone : the pathophysiology and diagnostic significance ] In this article the method of definition of double binders in lipids of blood serum in patients with different diseases basically atherosclerosis and ischemic heart disease , with use titration by ozone is given .", + "entities": [] + }, + { + "id": "1508", + "type": "gene", + "text": "Most smokers would prefer to quit smoking on their own .", + "entities": [] + }, + { + "id": "1509", + "type": "gene", + "text": "Dosage in both cases was 0 . 2 g / m2 .", + "entities": [] + }, + { + "id": "1510", + "type": "gene", + "text": "Thus our observations establish a functional link between the PKC and retinoid pathways , which are generally considered to have antagonistic activities on differentiation processes .", + "entities": [ + "PKC" + ] + }, + { + "id": "1511", + "type": "gene", + "text": "A 17 - mer oligodeoxynucleotide , corresponding to a region of the VtHb amino acid sequence was used as a hybridization probe to screen a Vitreoscilla genomic library constructed in broad - host - range cosmid vector pVK102 .", + "entities": [ + "VtHb amino acid sequence" + ] + }, + { + "id": "1512", + "type": "gene", + "text": "We report the successful use of electroconvulsive therapy for treatment of severe depression in a young man with adult GM2 gangliosidosis .", + "entities": [] + }, + { + "id": "1513", + "type": "gene", + "text": "The sensitivity of the vas deferens to adrenaline was also reduced in scorbutic guinea pigs , thus decreasing their fertility rate .", + "entities": [] + }, + { + "id": "1514", + "type": "gene", + "text": "In case of a pathologically convoluted internal carotid the common carotid artery was resected with an end - to - end anastomosis .", + "entities": [] + }, + { + "id": "1515", + "type": "gene", + "text": "OODG is a diagnostic method permitting assessment of ocular pulse curves and objective determination of blood pressures in the ophthalmic circulatory system ( retinal and ciliary arterial blood pressures ) simultaneously for both eyes , without dilatation of the pupils .", + "entities": [] + }, + { + "id": "1516", + "type": "gene", + "text": "Two classes of mutations were obtained : ( i ) those that altered the coding region of HOL1 , conferring the ability to take up histidinol ; and ( ii ) cis - acting mutations ( selected in a mutant HOL1 - 1 background ) that increased expression of the Hol1 protein .", + "entities": [ + "HOL1", + "HOL1 - 1", + "Hol1 protein" + ] + }, + { + "id": "1517", + "type": "gene", + "text": "Immunofluoresence data indicated that once bound to the mutant receptor , fluorescent - labeled RAP co - localized with markers of the endosomal pathway , whereas , in cells expressing the wild - type receptor , RAP fluorescence co - localized with lysosomal markers .", + "entities": [ + "RAP", + "RAP" + ] + }, + { + "id": "1518", + "type": "gene", + "text": "Therapy with dietary modification and triglyceride lowering drugs resulted in resolution of symptoms and parotid swelling in one patient .", + "entities": [] + }, + { + "id": "1519", + "type": "gene", + "text": "Evaluation of 1 , 10 - phenanthroline as a reagent for sialic acid determinations .", + "entities": [] + }, + { + "id": "1520", + "type": "gene", + "text": "Recently we have performed a detailed analysis of specific neuronal populations affected by the mutation which shed new light on the role of Krox - 20 in the segmentation and on the physiological consequences of its inactivation .", + "entities": [ + "Krox - 20" + ] + }, + { + "id": "1521", + "type": "gene", + "text": "The cut - off percentage positivity value was established using 500 brucellosis - positive and 500 brucellosis - negative serum samples , confirmed with reference to the sample data using the indirect ELISA kit .", + "entities": [] + }, + { + "id": "1522", + "type": "gene", + "text": "The requirement of PilE in pilus biogenesis was confirmed by demonstrating that chromosomal pilE insertion mutants were pilus - and twitching - motility deficient .", + "entities": [ + "PilE", + "chromosomal pilE insertion mutants" + ] + }, + { + "id": "1523", + "type": "gene", + "text": "CHAP and the Department of Veterans Affairs .", + "entities": [] + }, + { + "id": "1524", + "type": "gene", + "text": "Saccharomyces cerevisiae contains four known acyl - CoA synthetases ( fatty acid activation proteins , Faaps ) .", + "entities": [ + "acyl - CoA synthetases", + "fatty acid activation proteins", + "Faaps" + ] + }, + { + "id": "1525", + "type": "gene", + "text": "The heart rate , respiratory rate , arterial O2 and systemic vascular resistance were not significantly altered .", + "entities": [] + }, + { + "id": "1526", + "type": "gene", + "text": "PURPOSE / OBJECTIVES : To examine the question of whether an early first full - term pregnancy ( FFTP ) protects against breast cancer and whether interruption of the pregnancy with an induced abortion increases breast cancer risk .", + "entities": [] + }, + { + "id": "1527", + "type": "gene", + "text": "The products of genes ura10 and ura3 are proposed to participate in the channeling of orotidine monophosphate .", + "entities": [ + "ura10", + "ura3" + ] + }, + { + "id": "1528", + "type": "gene", + "text": "The association of clopamide and hydergine ( Brinedine ) in the treatment of the vasculo - renal syndromes of pregnancy", + "entities": [] + }, + { + "id": "1529", + "type": "gene", + "text": "STUDY DESIGN AND METHODS : A study was initiated to compare the collection of PBPCs with the new device , the AutoPBSC ( version [ V ] 6 . 0 with AutoPBSC tubing set ) , and that with the MNC ( mononuclear cell ) procedure ( V4 . 7 with white cell tubing set ) , for patients and healthy donors .", + "entities": [] + }, + { + "id": "1530", + "type": "gene", + "text": "Long - term effects of clofibrate ( Atromid - S ) on serum lipids in man .", + "entities": [] + }, + { + "id": "1531", + "type": "gene", + "text": "Nuclear protein phosphatase 2A dephosphorylates protein kinase A - phosphorylated CREB and regulates CREB transcriptional stimulation .", + "entities": [ + "Nuclear protein phosphatase 2A", + "protein kinase A", + "CREB", + "CREB" + ] + }, + { + "id": "1532", + "type": "gene", + "text": "In Rat - 1a cells the expression of human c - jun mRNA was associated with the ability to clone in soft agarose and form tumors in nude mice .", + "entities": [ + "human c - jun mRNA" + ] + }, + { + "id": "1533", + "type": "gene", + "text": "Finally , three new missense mutations , E138V , R254G , and P362R , were identified in the human AC gene from FD patients .", + "entities": [ + "human AC gene" + ] + }, + { + "id": "1534", + "type": "gene", + "text": "METHODS : Out of 171 patients receiving anticoagulation between July 1992 and December 1993 , 83 patients with hemispheric embolisms received heparin within 72 hours from onset ( activated partial thromboplastin time [ aPTT ] 1 . 5 times control value ) .", + "entities": [ + "thromboplastin" + ] + }, + { + "id": "1535", + "type": "gene", + "text": "They also interact with GTPase activating proteins encoded by IRA1 and IRA2 .", + "entities": [ + "GTPase activating proteins", + "IRA1", + "IRA2" + ] + }, + { + "id": "1536", + "type": "gene", + "text": "R . , Fleischmann , R . , Venter , J .", + "entities": [] + }, + { + "id": "1537", + "type": "gene", + "text": "Construction of a RIP1 deletion strain and isolation of temperature - sensitive mutants .", + "entities": [ + "RIP1" + ] + }, + { + "id": "1538", + "type": "gene", + "text": "Membrane - bound Steel factor induces more persistent tyrosine kinase activation and longer life span of c - kit gene - encoded protein than its soluble form .", + "entities": [ + "Steel factor", + "tyrosine kinase", + "c - kit" + ] + }, + { + "id": "1539", + "type": "gene", + "text": "Activities of hepatic cytochrome P - 450 - dependent metabolizing enzymes such as aminopyrine - and TMO N - demethylase and aniline hydroxylase activity were decreased by pretreatment of rats with cimetidine , whereas in the rats pretreated with ranitidine , these enzyme activities were not changed .", + "entities": [ + "cytochrome P - 450", + "aminopyrine - and TMO N - demethylase", + "aniline hydroxylase" + ] + }, + { + "id": "1540", + "type": "gene", + "text": "In a reconstituted human DNA repair system containing DNA polymerase beta and DNA ligase III - XRCC1 , accurate rejoining of a 3 ' mismatched base residue at a single - strand break is dependent on addition of the exonuclease .", + "entities": [ + "DNA polymerase beta", + "DNA ligase III", + "XRCC1" + ] + }, + { + "id": "1541", + "type": "gene", + "text": "The granules grew as the melted material immersed into the void space among the adhered particles .", + "entities": [] + }, + { + "id": "1542", + "type": "gene", + "text": "This was most pronounced during the initial phase of Erk activation .", + "entities": [ + "Erk" + ] + }, + { + "id": "1543", + "type": "gene", + "text": "Syndromes of abnormal fat redistribution and metabolic complications in HIV - infected patients .", + "entities": [] + }, + { + "id": "1544", + "type": "gene", + "text": "Use of the vena cava to extend the right renal vein for cadaver transplantation is controversial .", + "entities": [] + }, + { + "id": "1545", + "type": "gene", + "text": "271 : 31290 - 31295 , 1996 ) .", + "entities": [] + }, + { + "id": "1546", + "type": "gene", + "text": "Despite the presence of one additional ribonucleotide reductase , the nrdAB - encoded enzyme is essential to the aerobic growth of the cell because nrdAB - defective mutants of both species are not viable in the presence of oxygen .", + "entities": [ + "ribonucleotide reductase", + "nrdAB - encoded enzyme", + "nrdAB - defective mutants" + ] + }, + { + "id": "1547", + "type": "gene", + "text": "Electrophoretic mobility shift assays and competition experiments showed that site A is recognized by an NF1 protein .", + "entities": [ + "NF1 protein" + ] + }, + { + "id": "1548", + "type": "gene", + "text": "Under these schedules , a reinforced response run consisted of responding between eight and 12 times on one response key ( work key ) and then responding once on a second response key ( reinforced key ) .", + "entities": [] + }, + { + "id": "1549", + "type": "gene", + "text": "Conformational changes of the ferric uptake regulation protein upon metal activation and DNA binding ; first evidence of structural homologies with the diphtheria toxin repressor .", + "entities": [ + "ferric uptake regulation protein", + "diphtheria toxin repressor" + ] + }, + { + "id": "1550", + "type": "gene", + "text": "Various companies produce this type of lens .", + "entities": [] + }, + { + "id": "1551", + "type": "gene", + "text": "As a reflection of uncertainties in the estimates for individual sources , the 90th percentiles of PCDD / F releases for 1999 ranged up to 4 . 1 g I - TEQ / y .", + "entities": [] + }, + { + "id": "1552", + "type": "gene", + "text": "Human antitetanus serum : an unused wealth", + "entities": [] + }, + { + "id": "1553", + "type": "gene", + "text": "CONCLUSIONS : Lymphoscintigraphy of the cynomolgus monkey eyelids reveals discrete lymphatic drainage pathways for the upper and lower eyelids and a dual pathway for the central upper eyelid .", + "entities": [] + }, + { + "id": "1554", + "type": "gene", + "text": "Terminal deoxynucleotidyl transferase - mediated nick end labeling assays revealed that hormonal activation of the PAX3 repressors induced extensive apoptosis that correlated with down - regulation of BCL - X ( L ) expression .", + "entities": [ + "Terminal deoxynucleotidyl transferase", + "PAX3 repressors", + "BCL - X ( L )" + ] + }, + { + "id": "1555", + "type": "gene", + "text": "A given standard input function and a given value of distribution volume ( Vd ) used for the rCBF measurement of this method were calculated from the dynamic study by six normal volunteers .", + "entities": [] + }, + { + "id": "1556", + "type": "gene", + "text": "The majority of MRF units were behaviorally incongruent ; in the most frequently observed case , their activity failed to change reliably when behavior habituated .", + "entities": [] + }, + { + "id": "1557", + "type": "gene", + "text": "Zarix expected patient enrollment in Canadian clinical sites to begin in Spring 2001 [ 397955 ] , [ 405928 ] .", + "entities": [] + }, + { + "id": "1558", + "type": "gene", + "text": "Therefore , it is important to control hypertension and keep appropriate renal blood flow during living renal transplantation surgery .", + "entities": [] + }, + { + "id": "1559", + "type": "gene", + "text": "PTP - S3 differs from PTP - S4 in having a deletion of 19 amino acids corresponding to exon E1 .", + "entities": [ + "PTP - S3", + "PTP - S4" + ] + }, + { + "id": "1560", + "type": "gene", + "text": "EGF acts primarily by means of transactivation domain AF - 1 , whereas cAMP acts via transactivation domain AF - 2 of the ER .", + "entities": [ + "EGF", + "ER" + ] + }, + { + "id": "1561", + "type": "gene", + "text": "Because PET is also useful for the pretreatment and follow - up evaluation , the use of stereotactic PET in these patients can enable an accurate comparison of PET - based metabolic data with MR - based anatomical data .", + "entities": [] + }, + { + "id": "1562", + "type": "gene", + "text": "Each of these spliced mRNAs has an untranslated leader sequence of 249 bases and a single intron of approximately 540 bases which are contained entirely within TRs / IRs sequences .", + "entities": [] + }, + { + "id": "1563", + "type": "gene", + "text": "The highest decrease in mutagenic activity was observed when enzymatic bleaching was used together with chlorine .", + "entities": [] + }, + { + "id": "1564", + "type": "gene", + "text": "Effects of a booster dose of tetanus toxoid after different primary courses of vaccination : implications on the use of immune globulin .", + "entities": [ + "immune globulin" + ] + }, + { + "id": "1565", + "type": "gene", + "text": "If this is unavailable , then Supramid has a proven record for good tissue compatibility and resistance to infection .", + "entities": [] + }, + { + "id": "1566", + "type": "gene", + "text": "The cop region also harbors a region of plasmid incompatibility , inc , encompassing a stem - loop structure , the repA promoter , Prep , as well as two distinct RepA binding sites , BD - 1 and BD - 2 .", + "entities": [ + "cop region", + "inc", + "repA promoter", + "Prep", + "RepA binding sites" + ] + }, + { + "id": "1567", + "type": "gene", + "text": "PCNA mRNA has a 3 ' UTR antisense to yellow crescent RNA and is localized in ascidian eggs and embryos .", + "entities": [ + "PCNA mRNA" + ] + }, + { + "id": "1568", + "type": "gene", + "text": "Judge OKs docs ' bid for Chicago hospital .", + "entities": [] + }, + { + "id": "1569", + "type": "gene", + "text": "Other uncertainties in the dosimetry at Y - 12 and Vinca are unaltered .", + "entities": [] + }, + { + "id": "1570", + "type": "gene", + "text": "Effects of rhG - CSF on neutrophil functions and survival in sepsis induced diabetic rats .", + "entities": [ + "rhG - CSF" + ] + }, + { + "id": "1571", + "type": "gene", + "text": "Effects of posteroventral pallidotomy on Parkinson ' s disease .", + "entities": [] + }, + { + "id": "1572", + "type": "gene", + "text": "Furthermore , Rac1 activation of JNK or SRF , or induction of lamellipodia , was neither necessary nor sufficient for Rac1 transforming activity .", + "entities": [ + "Rac1", + "JNK", + "SRF", + "Rac1" + ] + }, + { + "id": "1573", + "type": "gene", + "text": "A 385 bp Glucocorticoid Response Unit ( GRU ) was identified whose glucocorticoid induction was enhanced by dibutyryl - cAMP and reduced by phorbol esters .", + "entities": [] + }, + { + "id": "1574", + "type": "gene", + "text": "These results suggest that different models of intestinal ischemia have different cytokine profiles and that the early TNF response associated with SMA occlusion model is primarily due to the laparotomy .", + "entities": [ + "TNF" + ] + }, + { + "id": "1575", + "type": "gene", + "text": "Studies on swine enteroviruses .", + "entities": [] + }, + { + "id": "1576", + "type": "gene", + "text": "Natural and induced malarias in western hemisphere monkeys .", + "entities": [] + }, + { + "id": "1577", + "type": "gene", + "text": "It was found that increase in the RH level boosts the current values by 2 - 3 orders of magnitude ; contrariwise , the voltage values rise by about three times with drop in the RH .", + "entities": [] + }, + { + "id": "1578", + "type": "gene", + "text": "73 : 658 - 666 , 1999 ) .", + "entities": [] + }, + { + "id": "1579", + "type": "gene", + "text": "In these cells , ras - induced transition is accompanied by a strong induction of AP - 1 - binding activity along with increased expression of CD44 mRNA and protein .", + "entities": [ + "ras", + "AP - 1", + "CD44 mRNA" + ] + }, + { + "id": "1580", + "type": "gene", + "text": "Binding site selection using in vitro - synthesized proteins reveals that the ROR alpha 1 and ROR alpha 2 isoforms bind DNA as monomers to hormone response elements composed of a 6 - bp AT - rich sequence preceding a half - site core motif PuGGTCA ( RORE ) .", + "entities": [ + "ROR alpha 1", + "ROR alpha 2 isoforms", + "RORE" + ] + }, + { + "id": "1581", + "type": "gene", + "text": "This study tested the hypothesis that sodium channel blocking drugs selectively prolong the late potential , or terminal low amplitude signal , portion of the signal - averaged QRS complex and that prolongation of the late potential would correlate with slowing of ventricular tachycardia .", + "entities": [] + }, + { + "id": "1582", + "type": "gene", + "text": "Proteinuria - - selected physiopathological and clinical problems", + "entities": [] + }, + { + "id": "1583", + "type": "gene", + "text": "IL - 1beta was significantly higher in endometrioma than in lesions of other localizations .", + "entities": [ + "IL - 1beta" + ] + }, + { + "id": "1584", + "type": "gene", + "text": "Soft - x - ray lasing at 32 . 6 nm in Ne - like Ti ions driven by 40 J of energy from two 650 - ps laser pulses .", + "entities": [] + }, + { + "id": "1585", + "type": "gene", + "text": "All carcasses resulted in contamination with aerobic mesophilic bacteria in the range from 6 x 10 ( 3 ) to 1 . 2 x 10 ( 6 ) CFU / ml liquid washed , and 94 % them with sporulate bacteria , the threshold being under 100 CFU / ml ( Figure 1 ) .", + "entities": [] + }, + { + "id": "1586", + "type": "gene", + "text": "Animal age and sex had no significant effects on CSF composition , but serum IgG concentration increased with age .", + "entities": [ + "IgG" + ] + }, + { + "id": "1587", + "type": "gene", + "text": "The TYAC / P1 resource , derivative STSs , and polymorphisms constitute an enabling resource to further studies of telomere structure and function and a means for physical and genetic map integration and closure .", + "entities": [] + }, + { + "id": "1588", + "type": "gene", + "text": "There were significant differences ( p < 0 . 05 ) between the fracture and nonfracture groups in the total femur BMD ( 13 % ) , trabecular BMD in the distal radius ( 4 % ) , and the fractal dimension in the radiographs ( FD2 ) ( 3 % ) .", + "entities": [] + }, + { + "id": "1589", + "type": "gene", + "text": "Transformed cell lines expressing solely E1a or E1a and E1b gene products derived from these viruses display enhanced anchorage - independent growth at 37 degrees C versus 32 degrees C and display a cytoskeletal architecture resembling untransformed fibroblastic CREF cells .", + "entities": [ + "E1a", + "E1a", + "E1b gene products" + ] + }, + { + "id": "1590", + "type": "gene", + "text": "Utility of OAE screener ( GSI 70 ) for the evaluation of distortion product otoacoustic emissions ] The purpose of this study was to investigate the ability of the OAE screener GSI 70 to evaluate of cochlea function in neonates , infants and adults .", + "entities": [] + }, + { + "id": "1591", + "type": "gene", + "text": "Evidence for such peak shifts has been found in the responses of auditory nerve fibers , cochlear microphonics , and the responses of outer hair cells and supporting cells in the cochlea , as well as in basilar membrane vibration measurements , and indirectly , in psychophysical data .", + "entities": [] + }, + { + "id": "1592", + "type": "gene", + "text": "Similar to the mouse gene , the 5 ' flanking region of human CD79 alpha lacks a TATA box ; however , unlike mouse CD79 alpha , a classical octamer motif could not be identified in the human gene .", + "entities": [ + "human CD79 alpha", + "mouse CD79 alpha" + ] + }, + { + "id": "1593", + "type": "gene", + "text": "Of 202 initially seronegative caretakers ( observed for an average of 305 days per woman ) , 19 seroconverted , for an annual seroconversion rate of 11 percent .", + "entities": [] + }, + { + "id": "1594", + "type": "gene", + "text": "Activation of a CRE - dependent junB promoter / chloramphenicol acetyltransferase ( CAT ) reporter gene by the BCR was also blocked by SB203580 .", + "entities": [ + "junB promoter", + "chloramphenicol acetyltransferase", + "CAT", + "BCR" + ] + }, + { + "id": "1595", + "type": "gene", + "text": "WA constructs afforded relaxed and positive topoisomers , and cyclization kinetics indicated slow interconversion of precursors to the two topoisomers .", + "entities": [] + }, + { + "id": "1596", + "type": "gene", + "text": "The mean serum creatinine levels were similar at one year ( SPK 1 . 8 , KTA 1 . 9 mg / d ) . ( ABSTRACT TRUNCATED AT 250 WORDS )", + "entities": [] + }, + { + "id": "1597", + "type": "gene", + "text": "Molecular characterization of the 50 - and 57 - kDa subunits of the bovine vacuolar proton pump .", + "entities": [ + "bovine vacuolar proton pump" + ] + }, + { + "id": "1598", + "type": "gene", + "text": "Protein electrophoresis showed decreased albumin levels in both groups , with lower values in G2 .", + "entities": [ + "albumin" + ] + }, + { + "id": "1599", + "type": "gene", + "text": "Induced gamma - ray spectroscopy", + "entities": [] + }, + { + "id": "1600", + "type": "gene", + "text": "Lung prostacyclin production may be related to flow .", + "entities": [] + }, + { + "id": "1601", + "type": "gene", + "text": "Electrophoretic mobility shift assays using crude extracts from FREJ4 cells revealed the binding of a member ( s ) of the Ets family of transcription factors to the P4 EBS , as well as the interaction of two members of the Sp1 family , Sp1 and Sp3 , with the adjacent GC box .", + "entities": [ + "Ets family of transcription factors", + "P4 EBS", + "Sp1 family", + "Sp1", + "Sp3" + ] + }, + { + "id": "1602", + "type": "gene", + "text": "The final predicted structure has an overall backbone deviation of 0 . 7 A from that of ras - p21 .", + "entities": [ + "ras", + "p21" + ] + }, + { + "id": "1603", + "type": "gene", + "text": "Using homology cloning techniques , we identified a mouse homologue of E ( Pc ) , termed Epc1 , a yeast protein that we name EPL1 , and as well as additional ESTs from Caenorhabditis elegans , mice and humans .", + "entities": [ + "E ( Pc )", + "Epc1", + "EPL1" + ] + }, + { + "id": "1604", + "type": "gene", + "text": "Characterization of the regulon controlled by the leucine - responsive regulatory protein in Escherichia coli .", + "entities": [ + "leucine - responsive regulatory protein" + ] + }, + { + "id": "1605", + "type": "gene", + "text": "The 3 ' region , GA2 , is necessary for maximal expression .", + "entities": [ + "GA2" + ] + }, + { + "id": "1606", + "type": "gene", + "text": "Some mutations affected Dhfr in a qualitative manner , such as by changing the startpoint of one of the major Dhfr transcripts or changing the relative abundance of the two major Dhfr transcripts .", + "entities": [ + "Dhfr", + "Dhfr transcripts", + "Dhfr transcripts" + ] + }, + { + "id": "1607", + "type": "gene", + "text": "CONCLUSION : A valve - like mechanism formed by the capsulorhexis rim partially adhered to the IOL optic can occur postoperatively .", + "entities": [] + }, + { + "id": "1608", + "type": "gene", + "text": "To investigate the effects of exogenous hyaluronic acid , the development of port - site metastasis was examined using mouse adenocarcinoma cell - line colon 26 cells .", + "entities": [] + }, + { + "id": "1609", + "type": "gene", + "text": "The effect of CBZ and DPH can be explained by interference with thyroid hormone binding to TBG combined with enzyme - induced increased metabolic clearance rate of thyroid hormones without homeostatic maintenance of premedication levels of FT4 and FT3 .", + "entities": [ + "TBG" + ] + }, + { + "id": "1610", + "type": "gene", + "text": "The gene includes three exons and two introns within 1 . 6 kilobases of DNA , and the entire open reading frame for glycoprotein IX is included within the third exon .", + "entities": [ + "glycoprotein IX" + ] + }, + { + "id": "1611", + "type": "gene", + "text": "The full - length N gene , encoded by open reading frame 7 , was cloned from the Canadian PRRS virus , PA - 8 .", + "entities": [ + "N gene" + ] + }, + { + "id": "1612", + "type": "gene", + "text": "Transformations in the morphine series .", + "entities": [] + }, + { + "id": "1613", + "type": "gene", + "text": "Dissociable effects of lidocaine inactivation of the rostral and caudal basolateral amygdala on the maintenance and reinstatement of cocaine - seeking behavior in rats .", + "entities": [] + }, + { + "id": "1614", + "type": "gene", + "text": "Even if the electrocardiographic signs are subdued , the underlying blockade of I ( Kr ) current may precipitate the occurrence of arrhythmia .", + "entities": [] + }, + { + "id": "1615", + "type": "gene", + "text": "During the past decade , different types of endogenous retroviral sequences have been defined in the human genome usually by low stringency hybridization employing DNA probes of evolutionary conserved animal retrovirus genes .", + "entities": [] + }, + { + "id": "1616", + "type": "gene", + "text": "Menetrier disease in a child .", + "entities": [] + }, + { + "id": "1617", + "type": "gene", + "text": "A stable interface depends on overall stress and microstress distribution on the bone , particularly trabecular bone .", + "entities": [] + }, + { + "id": "1618", + "type": "gene", + "text": "The 5 - year OS for stage IIIB was 30 . 9 % , compared to 7 . 8 % for stage IV .", + "entities": [] + }, + { + "id": "1619", + "type": "gene", + "text": "Comparison of the deduced amino acid sequences with protein sequences of T . pyriformis H2As showed only two and three differences respectively , in a total of 137 amino acids for H2A1 , and 132 amino acids for H2A2 , indicating the two genes arose before the divergence of these two species .", + "entities": [ + "H2As", + "H2A1", + "H2A2" + ] + }, + { + "id": "1620", + "type": "gene", + "text": "Structural changes in the C - terminus of Ca2 + - bound rat S100B ( beta beta ) upon binding to a peptide derived from the C - terminal regulatory domain of p53 .", + "entities": [ + "rat S100B", + "beta beta", + "p53" + ] + }, + { + "id": "1621", + "type": "gene", + "text": "Identification of RNase T as a high - copy suppressor of the UV sensitivity associated with single - strand DNA exonuclease deficiency in Escherichia coli .", + "entities": [ + "RNase T", + "single - strand DNA exonuclease" + ] + }, + { + "id": "1622", + "type": "gene", + "text": "Thrombolytic therapy in spontaneous coronary artery dissection .", + "entities": [] + }, + { + "id": "1623", + "type": "gene", + "text": "Thus , through a change in conformation upon repair of the 6RG lesion , MGMT switches from a DNA repair factor to a transcription regulator ( R - MGMT ) , enabling the cell to sense as well as respond to mutagens .", + "entities": [ + "MGMT", + "R - MGMT" + ] + }, + { + "id": "1624", + "type": "gene", + "text": "FK 33 - 824 , a methionine - enkephalin analogue , suppressed plasma ACTH to 85 % of basal level , while bromocriptine ( CB - 154 ) caused no significant change .", + "entities": [ + "enkephalin", + "ACTH" + ] + }, + { + "id": "1625", + "type": "gene", + "text": "Precipitating antibodies for Thermophilic actinomycetes and M . f . were negative .", + "entities": [] + }, + { + "id": "1626", + "type": "gene", + "text": "In a group of 13 patients with obliterative arteriopathies of the lower limbs the plasma levels of thrombomodulin ( TM ) , betathromboglobulin ( beta - TG ) , D - dimer ( DD ) and plasminogen activator - inhibitor ( pAI - 1 ) were measured , and compared to the values obtained from 10 healthy volunteers .", + "entities": [ + "thrombomodulin", + "TM", + "betathromboglobulin", + "beta - TG", + "plasminogen activator - inhibitor", + "pAI - 1" + ] + }, + { + "id": "1627", + "type": "gene", + "text": "J .", + "entities": [] + }, + { + "id": "1628", + "type": "gene", + "text": "The 3 ' stem - loop is highly divergent in structure among species and lies immediately upstream of the binding site for Sm proteins .", + "entities": [ + "Sm proteins" + ] + }, + { + "id": "1629", + "type": "gene", + "text": "Elimination of natural antibodies in discordant xenografts", + "entities": [] + }, + { + "id": "1630", + "type": "gene", + "text": "Thus , Esigma54 promoters are responsive to CRP , a protein unrelated to sigma54 activators , and the repression exerted is the direct result of an interaction between Esigma54 and the CRP - cAMP complex .", + "entities": [ + "Esigma54 promoters", + "CRP", + "sigma54 activators", + "Esigma54", + "CRP - cAMP complex" + ] + }, + { + "id": "1631", + "type": "gene", + "text": "The molecular mechanism by which Gle2p and the Gle2p - Nup116p interaction function in mRNA export is unknown .", + "entities": [ + "Gle2p", + "Gle2p", + "Nup116p" + ] + }, + { + "id": "1632", + "type": "gene", + "text": "The ARX2 procedure models the recorded signal as the sum of three signals : ( a ) the background EEG activity , modelled as an autoregressive process driven by a white noise ; ( b ) a filtered version of a reference signal carrying the average information contained in each sweep ; ( c ) a signal due to the ocular artefact propagation .", + "entities": [] + }, + { + "id": "1633", + "type": "gene", + "text": "A novel Drosophila A kinase anchor protein , Drosophila A kinase anchor protein 200 ( DAKAP200 ) , is predicted to be involved in routing , mediating , and integrating signals carried by cAMP , Ca ( 2 + ) , and diacylglycerol ( Li , Z . , Rossi , E .", + "entities": [ + "Drosophila A kinase anchor protein", + "Drosophila A kinase anchor protein 200", + "DAKAP200" + ] + }, + { + "id": "1634", + "type": "gene", + "text": "As the components of these complexes , at least five TRBPs ( p30 , p37 , p46 , p50 , and p56 ) showing specific binding to the TAR RNA were detected in the uv cross - linking assay .", + "entities": [ + "TRBPs", + "p30", + "p37", + "p46", + "p50", + "p56" + ] + }, + { + "id": "1635", + "type": "gene", + "text": "Aeromonas salmonicida possesses two genes encoding homologs of the major outer membrane protein , OmpA .", + "entities": [ + "major outer membrane protein", + "OmpA" + ] + }, + { + "id": "1636", + "type": "gene", + "text": "In addition , on the Cohler ' s maternal scale , Korean mothers were found to view their infants as more passive and dependent than American mothers did ( P less than 0 . 00 ) .", + "entities": [] + }, + { + "id": "1637", + "type": "gene", + "text": "Copyright 2000 The Royal College of Radiologists .", + "entities": [] + }, + { + "id": "1638", + "type": "gene", + "text": "After 24 hour incubation , total cell - associated IL - 1Ra and IL - 1 beta were measured by specific radioimmunoassay .", + "entities": [ + "IL - 1Ra", + "IL - 1 beta" + ] + }, + { + "id": "1639", + "type": "gene", + "text": "Our results suggest that the pattern of blood supply is relevant to the structural organisation of mature lamellar bone around the implant .", + "entities": [] + }, + { + "id": "1640", + "type": "gene", + "text": "SEA was recorded with bidirectional filters at 25 - 250 HZ and 40 - 250 Hz using Simson method .", + "entities": [] + }, + { + "id": "1641", + "type": "gene", + "text": "On - line angioscopic images of tissue flaps floating in the lumen , recent or structured thrombi , artery wall dissections , plaque ruptures , deep fissurations and sub - intimal haemorrhages demonstrate , in live colour , the pathophysiological mechanisms of coronary artery stenosis .", + "entities": [] + }, + { + "id": "1642", + "type": "gene", + "text": "Performance on two verbal measures - the National Adult Reading Test - Revised ( NART - R ) and the Vocabulary subtest from the Wechsler Adult Intelligence Scale - Revised ( WAIS - R ) - showed strong correlations with level of education .", + "entities": [] + }, + { + "id": "1643", + "type": "gene", + "text": "Volunteers were irradiated on their backs with suberythemal UV daily for 5 d after application of the sunscreens and their base lotion to different sites .", + "entities": [] + }, + { + "id": "1644", + "type": "gene", + "text": "The same ligands also exhibit a similar inhibitory effect on PDGF - BB - dependent [ 3H ] thymidine incorporation in PAE cells expressing the PDGF beta - receptors .", + "entities": [ + "PDGF - BB", + "PDGF beta - receptors" + ] + }, + { + "id": "1645", + "type": "gene", + "text": "In macrophages , LPS - inducible HIV - 1 gene expression is mediated in part by binding of NF - kappa B to identical tandem binding sites located within the long terminal repeat ( LTR ) .", + "entities": [ + "NF - kappa B" + ] + }, + { + "id": "1646", + "type": "gene", + "text": "For this purpose , the immediate and the final ( after swelling ) fixation strengths of two variations of the swellable bone anchor designs ( a smooth anchor and a screw anchor ) were measured in two different foams ( used to simulate bone ) with different densities .", + "entities": [] + }, + { + "id": "1647", + "type": "gene", + "text": "The domain structure of bovine LTBP - 2 is very similar to that of the human LTBP - 2 , containing 20 examples of 6 - cysteine epidermal growth factor - like repeats , 16 of which have the consensus sequence for calcium binding , together with 4 examples of 8 - cysteine motifs characteristic of fibrillins and LTBP - 1 .", + "entities": [ + "bovine LTBP - 2", + "human LTBP - 2", + "epidermal growth factor - like repeats", + "fibrillins", + "LTBP - 1" + ] + }, + { + "id": "1648", + "type": "gene", + "text": "We have isolated cDNAs for a gene coding for a G protein alpha subunit from tomato ( Lycopersicon esculentum , cv .", + "entities": [ + "G protein alpha subunit from tomato" + ] + }, + { + "id": "1649", + "type": "gene", + "text": "Natural FL protein has been purified from a stromal cell line and shown to be a 65 kD nondisulfide - linked homodimeric glycoprotein comprised of 30 kD subunits , each containing 12 kD of N - and O - linked sugars .", + "entities": [ + "FL protein" + ] + }, + { + "id": "1650", + "type": "gene", + "text": "To further our knowledge about the systemic humoral immune system response to weak hapten - syngeneic or allogeneic protein conjugates ( corrosion and wear products of metallic orthopedic devices ) , a sensitive enzyme - linked immunosorbent assay ( ELISA ) method for testing for antibody ( humoral immunity ) to metals was developed .", + "entities": [] + }, + { + "id": "1651", + "type": "gene", + "text": "The 7 - kb mRNA differs by alternative splicing such that it encodes a protein with a distinct amino terminus .", + "entities": [] + }, + { + "id": "1652", + "type": "gene", + "text": "The combination of F1 and F2 which was the best predictor of CHD in this population ( G1 ) might be interpreted as reflecting trunk adiposity mainly abdominal .", + "entities": [] + }, + { + "id": "1653", + "type": "gene", + "text": "Between acoR and acoXABC , two different types of sequences with dual rotational symmetry [ CAC - ( N11 to N18 ) - GTG and TGT - ( N10 to N14 ) - ACA ] were found ; these sequences are similar to NtrC and NifA upstream activator sequences , respectively .", + "entities": [ + "acoR", + "acoXABC", + "NtrC", + "NifA upstream activator sequences" + ] + }, + { + "id": "1654", + "type": "gene", + "text": "Analysis by cell surface immunofluorescence showed that the UL28 gene is not required for expression of viral glycoproteins on the surface of infected cells .", + "entities": [ + "UL28 gene" + ] + }, + { + "id": "1655", + "type": "gene", + "text": "By contrast , kidneys from rats with chronic metabolic acidosis produced significantly more NH3 than both these groups ( 2 . 73 + / - 0 . 29 mumol X min - 1 X g - 1 ) .", + "entities": [] + }, + { + "id": "1656", + "type": "gene", + "text": "Marinol / marijuana usage was associated with depressed CD4 + counts and elevated amylase levels within the DDI subgroup .", + "entities": [ + "CD4 +", + "amylase" + ] + }, + { + "id": "1657", + "type": "gene", + "text": "Transcription of the gene for ivanolysin O and expression of other genes of the virulence gene cluster in L . ivanovii were dependent on PrfA .", + "entities": [ + "ivanolysin O", + "virulence gene cluster in L . ivanovii", + "PrfA" + ] + }, + { + "id": "1658", + "type": "gene", + "text": "Spectroscopy of negative ions utilizing multiphoton detachment in a Raman coupling regime .", + "entities": [] + }, + { + "id": "1659", + "type": "gene", + "text": "On catabolism of aminoketones in climacteric age", + "entities": [] + }, + { + "id": "1660", + "type": "gene", + "text": "Ten - year experience with one - stage proctocolectomy and anal ileostomy .", + "entities": [] + }, + { + "id": "1661", + "type": "gene", + "text": "The minimum inhibitory concentrations ( MICs ) of ketoconazole , miconazole , itraconazole , fluconazole , and amphotericin B were significantly influenced by the inoculum size , regardless of the techniques used .", + "entities": [] + }, + { + "id": "1662", + "type": "gene", + "text": "An experiment on the return - of - fear ( ROF ) was carried out on 40 snake - or spider - phobic subjects in order to determine whether an arousing event that occurs shortly before retest influences the magnitude of the ROF .", + "entities": [] + }, + { + "id": "1663", + "type": "gene", + "text": "To begin to characterize the role of the RNA subunits in enzyme function and substrate specificity , we swapped two hairpin structures ( MRP3 and P3 ) between RNase MRP RNA and RNase P RNA of S . cerevisiae .", + "entities": [ + "RNase MRP RNA", + "RNase P RNA of S . cerevisiae" + ] + }, + { + "id": "1664", + "type": "gene", + "text": "OBJECTIVE : To evaluate the overall performance of a new oscillometric wrist blood pressure monitor ( Braun PrecisionSensor , Braun GmbH , Kronberg , Germany ) as defined by the ANSI / AAMI SP10 - 1992 guidelines , and to analyze the data for the optimized selection of the algorithm that derives the blood pressure values from the oscillometric blood pressure curves .", + "entities": [] + }, + { + "id": "1665", + "type": "gene", + "text": "The basal promoter strength of constructs that contained deletions in the U5 region of the LTR was analyzed by chloramphenicol acetyltransferase ( CAT ) assays following transfection of HeLa cells or Jurkat T - cells in the presence or absence of viral transactivator tax protein .", + "entities": [ + "U5 region", + "chloramphenicol acetyltransferase", + "CAT", + "tax" + ] + }, + { + "id": "1666", + "type": "gene", + "text": "Growth factor stimulation rapidly induces a reversible change in the electrophoretic mobility of the ternary complex , accompanied by increased phosphorylation of the Elk - 1 C - terminal region and by the activation of a 42 kd cellular Elk - 1 kinase .", + "entities": [ + "Elk - 1 C - terminal region", + "42 kd cellular Elk - 1 kinase" + ] + }, + { + "id": "1667", + "type": "gene", + "text": "Purified spleen GAP accelerated hydrolysis of GTP bound to recombinant ARF1 , ARF3 , ARF5 , and ARF6 ; no effect of NH2 - terminal myristoylation was observed .", + "entities": [ + "GAP", + "recombinant ARF1", + "ARF3", + "ARF5", + "ARF6" + ] + }, + { + "id": "1668", + "type": "gene", + "text": "Hepatitis C virus infection is a risk factor for liver failure from veno - occlusive disease after bone marrow transplantation .", + "entities": [] + }, + { + "id": "1669", + "type": "gene", + "text": "These results suggest that low concentrations of IL - 1 beta may be useful for nonsurgical treatment of human vitreous hemorrhage .", + "entities": [ + "IL - 1 beta" + ] + }, + { + "id": "1670", + "type": "gene", + "text": "Among them , 26 cases were benign and 34 malignant .", + "entities": [] + }, + { + "id": "1671", + "type": "gene", + "text": "The regulation of Myf - 5 and MyoD function by a cAMP - dependent pathway may partly explain how external signals generated by serum and certain peptide growth factors can be transduced to the nucleus and inhibit dominant - acting factors that are responsible for myoblast differentiation .", + "entities": [ + "Myf - 5", + "MyoD" + ] + }, + { + "id": "1672", + "type": "gene", + "text": "Effects of beta - adrenergic receptor blockade on airway conductance and lung volume in normal and asthmatic subjects .", + "entities": [ + "beta - adrenergic receptor" + ] + }, + { + "id": "1673", + "type": "gene", + "text": "Several Src SH3 - binding proteins were phosphorylated in Src - transformed cells .", + "entities": [ + "Src SH3 - binding proteins", + "Src" + ] + }, + { + "id": "1674", + "type": "gene", + "text": "This suggests that mechanisms other than an excessive increase in myocardial oxygen demand may be responsible for the many episodes occurring outside the hospital .", + "entities": [] + }, + { + "id": "1675", + "type": "gene", + "text": "12 : 2684 - 2697 , 1998 ) : a key step of this model is the activation of the MAPK Fus3p through the G ( betagamma ) - dependent relocalization of the Ste5p - MAPK cascade to the plasma membrane .", + "entities": [ + "MAPK Fus3p", + "G ( betagamma )", + "Ste5p", + "MAPK" + ] + }, + { + "id": "1676", + "type": "gene", + "text": "Hyperactivation of Cdc2 in fission yeast causes cells to undergo a lethal premature mitosis called mitotic catastrophe .", + "entities": [ + "Cdc2" + ] + }, + { + "id": "1677", + "type": "gene", + "text": "METHODS : P - selectin expression of nonstimulated and ADP - stimulated platelets was flow cytometrically measured before the clopidogrel loading dose and on 3 consecutive days in 52 patients with coronary artery disease : 21 patients in group 1 received 300 mg of clopidogrel after stent implantation and 11 patients in group 2 received the higher 450 - mg clopidogrel loading dose followed by a daily dose of 75 mg of clopidogrel for both groups .", + "entities": [ + "P - selectin" + ] + }, + { + "id": "1678", + "type": "gene", + "text": "In one glioblastoma cell line , a Shc - associated p190 was identified as the activated PDGFR .", + "entities": [ + "Shc", + "p190", + "PDGFR" + ] + }, + { + "id": "1679", + "type": "gene", + "text": "We screened a K562 cDNA library and identified novel transcripts , MZF1B and MZF1C .", + "entities": [ + "MZF1B", + "MZF1C" + ] + }, + { + "id": "1680", + "type": "gene", + "text": "Relapse of leukemia after prolonged remission .", + "entities": [] + }, + { + "id": "1681", + "type": "gene", + "text": "Anisotropic heat transport in the octylcyanobiphenyl ( 8CB ) liquid crystal .", + "entities": [] + }, + { + "id": "1682", + "type": "gene", + "text": "The mean marginal discrepancy of provisional restorations was compared for restorations fabricated from stone , low - viscosity poly ( vinyl siloxane ) , and medium - viscosity poly ( vinyl siloxane ) .", + "entities": [] + }, + { + "id": "1683", + "type": "gene", + "text": "Alignment of the cervical spine , vertebral abnormalities , and disc changes also were evaluated .", + "entities": [] + }, + { + "id": "1684", + "type": "gene", + "text": "Cell .", + "entities": [] + }, + { + "id": "1685", + "type": "gene", + "text": "In the studies described in this report , we have investigated the signaling pathway ( s ) that are responsible for CREB activation in normal T cells .", + "entities": [ + "CREB" + ] + }, + { + "id": "1686", + "type": "gene", + "text": "Schedule 2 , in which 2 . 4 mg / kg c - DDP was administered immediately before X - ray on 5 consecutive days produced the highest degree of enhancement of radiation effect ( expressed as dose - effect factor ) ; and the next greatest enhancement was produced by 12 mg / kg c - DDP administered 24 h before the start of fractionated daily radiotherapy .", + "entities": [] + }, + { + "id": "1687", + "type": "gene", + "text": "Interestingly , an antibody against N - SMase can abrogate Ox - LDL - and TNF - alpha - induced apoptosis and therefore may be useful for in vivo studies of apoptosis in experimental animals .", + "entities": [ + "N - SMase", + "Ox - LDL", + "TNF - alpha" + ] + }, + { + "id": "1688", + "type": "gene", + "text": "Influence of oil emulsions and diphenyl on post - harvest physiconutritional changes in Kagzi limes ( Citrus aurantifolia ) was studied .", + "entities": [] + }, + { + "id": "1689", + "type": "gene", + "text": "Furthermore , the use of zero - loss filtering in combination with exit wavefront reconstruction is considerably more effective at removing the effects of multiple elastic and inelastic scattering and microscope objective lens aberrations than either technique by itself .", + "entities": [] + }, + { + "id": "1690", + "type": "gene", + "text": "However , it is only one - half and one - third the size of the proteolipids from M . thermoautotrophicum and M . jannaschii , respectively .", + "entities": [] + }, + { + "id": "1691", + "type": "gene", + "text": "ahaK is expressed in Escherichia coli , and it is incorporated into the cytoplasmic membrane despite the different chemical natures of lipids from archaea and bacteria .", + "entities": [ + "ahaK" + ] + }, + { + "id": "1692", + "type": "gene", + "text": "In agreement with this southern blotting of mouse DNA with SmN probes reveals bands , additional to those derived from the pseudogene , which are characteristic of an intron - containing SmN gene .", + "entities": [ + "SmN", + "SmN gene" + ] + }, + { + "id": "1693", + "type": "gene", + "text": "If the haemoglobin concentration ( Hb ) was less than 12 g dL - 1 they were given a four week course of ferrous sulphate .", + "entities": [ + "haemoglobin", + "Hb" + ] + }, + { + "id": "1694", + "type": "gene", + "text": "Sustained activation of p21 expression is proposed to be a distinguishing feature of the activity of NGF that contributes to PC12 growth arrest during differentiation", + "entities": [ + "p21", + "NGF" + ] + }, + { + "id": "1695", + "type": "gene", + "text": "Viable flap areas were established following vascular pedicle ligation ( both vessels or only artery or vein ) , on the third day after flap replantation in both island and free flaps .", + "entities": [] + }, + { + "id": "1696", + "type": "gene", + "text": "This demonstrates that treatment of the graft recipient for a relatively short period during and after surgery has a favorable effect on the survival of grafted dopaminergic neurons .", + "entities": [] + }, + { + "id": "1697", + "type": "gene", + "text": "We have identified two Marek ' s Disease Virus ( MDV ) genes within the EcoRI - B fragment of MDV - GA genomic DNA .", + "entities": [ + "EcoRI - B fragment" + ] + }, + { + "id": "1698", + "type": "gene", + "text": "This report focused on the relationship between Type A behavior and eight basic emotion dimensions .", + "entities": [] + }, + { + "id": "1699", + "type": "gene", + "text": "Implications of this observation for pediatrics are discussed .", + "entities": [] + }, + { + "id": "1700", + "type": "gene", + "text": "[ 82Br ] MISO was prepared by irradiating samples of Br - MISO in a SLOWPOKE reactor for 2 h at a thermal neutron flux of 10 ( 12 ) n cm - 2 s - 1 .", + "entities": [] + }, + { + "id": "1701", + "type": "gene", + "text": "The size of the infarct was determined using the creatine kinase integral method .", + "entities": [ + "creatine kinase" + ] + }, + { + "id": "1702", + "type": "gene", + "text": "Three new aromatase inhibitors have recently completed phase III evaluation as treatment of metastatic breast cancer in post - menopausal women whose disease has progressed despite tamoxifen therapy : anastrozole ( ARIMIDEX , Zeneca ) , letrozole ( FEMARA , Novartis ) and vorozole ( RIVIZOR , Janssen ) .", + "entities": [ + "aromatase" + ] + }, + { + "id": "1703", + "type": "gene", + "text": "The most common risk factor reported for both recent and all other hepatitis C cases was a history of injecting drug use , although the proportion of cases with that history was different in NT from ACT and Queensland .", + "entities": [] + }, + { + "id": "1704", + "type": "gene", + "text": "Echocardiography revealed right ventricular diastolic collapse ( RVDC ) without physical signs of cardiac tamponade .", + "entities": [] + }, + { + "id": "1705", + "type": "gene", + "text": "It is reported that , at present , most of the MRSAs spreading in Japan are acceleratedly acquiring resistance to many drugs , and especially , they are developing high resistance against beta - lactams .", + "entities": [] + }, + { + "id": "1706", + "type": "gene", + "text": "CONCLUSIONS : These findings indicate a physical barrier of oesophageal surfactant which could offer some degree of protection against gastro - oesophageal reflux but one which is particularly prone to attack by bile .", + "entities": [] + }, + { + "id": "1707", + "type": "gene", + "text": "Functional disorders of the ureter following gynecologic surgery", + "entities": [] + }, + { + "id": "1708", + "type": "gene", + "text": "On the third occasion water ( W ) was ingested throughout the run .", + "entities": [] + }, + { + "id": "1709", + "type": "gene", + "text": "HDL - cholesterol ( + 6 % , P less than . 01 ) and apolipoprotein A - I ( + 6 % , P less than . 01 ) concentrations increased significantly only in the young .", + "entities": [ + "HDL - cholesterol", + "apolipoprotein A - I" + ] + }, + { + "id": "1710", + "type": "gene", + "text": "In 14 cases , isolates were biotyped yielding eight with biotype II , four with biotype III , and one each with biotypes IV and V .", + "entities": [] + }, + { + "id": "1711", + "type": "gene", + "text": "PM 12 or 18 mg / kg daily plus a standard dose of SB for 21 days was statistically more effective than SB in producing a final cure for patients with VL in Bihar , India .", + "entities": [] + }, + { + "id": "1712", + "type": "gene", + "text": "CONCLUSIONS : EBCT technology allows minimally invasive evaluation of intramyocardial microcirculatory function and permits assessment of microvascular BV distribution in different functional components .", + "entities": [] + }, + { + "id": "1713", + "type": "gene", + "text": "An increase in hypothalamic expression of at least two of the erbB receptors is initiated before the pubertal augmentation of gonadal steroid secretion and is completed on the day of the first preovulatory surge of gonadotropins .", + "entities": [ + "erbB receptors", + "gonadotropins" + ] + }, + { + "id": "1714", + "type": "gene", + "text": "Promoter elements include an atypical TATA box ( GTTA ) , one CCAAT box much further from the initiation site , three reverse compliments of CCAAT ( ATTGG ) , and two pyrimidine - rich nucleotide stretches .", + "entities": [] + }, + { + "id": "1715", + "type": "gene", + "text": "Comparisons of rrnB P1 - lacZ expression at different ppGpp levels is interpreted for the rpoD ( P504L ) mutant as resulting from a hypersensitivity to ppGpp .", + "entities": [ + "P1", + "lacZ", + "rpoD ( P504L ) mutant" + ] + }, + { + "id": "1716", + "type": "gene", + "text": "Measurement of SaO2 at moderate altitude can be helpful in the care of both healthy and ill newborns or infants .", + "entities": [] + }, + { + "id": "1717", + "type": "gene", + "text": "Accumulated evidence indicates that , upon stimulation with interferon - gamma ( IFN - gamma ) , three beta - type subunits , designated LMP2 , LMP7 , and PSMB10 , are incorporated into the 20S proteasome by displacing the housekeeping beta - type subunits designated PSMB6 , PSMB5 , and PSMB7 , respectively .", + "entities": [ + "interferon - gamma", + "IFN - gamma", + "LMP2", + "LMP7", + "PSMB10", + "20S proteasome", + "PSMB6", + "PSMB5", + "PSMB7" + ] + }, + { + "id": "1718", + "type": "gene", + "text": "All other ejaculate parameters ( density , motility , swelling test , penetration test ) remained unchanged , and there was only one post - therapeutic pregnancy .", + "entities": [] + }, + { + "id": "1719", + "type": "gene", + "text": "More recently , however , a number of developments such as the successful use of the inhaled steroid budesonide and oral dexamethasone have reinforced the argument for using steroids .", + "entities": [] + }, + { + "id": "1720", + "type": "gene", + "text": "Pentane and ethane , which arise during lipid peroxidation in vivo , were measured by gas chromatography in breath samples of rats fed for 8 weeks a vitamin E - deficient diet to which had been added 0 , 11 , or 40 IU vitamin E acetate per kg .", + "entities": [] + }, + { + "id": "1721", + "type": "gene", + "text": "Inhibition of Fusarium moniliforme var . subglutinans , the causal agent of pine pitch canker , by the soil bacterium Arthrobacter sp .", + "entities": [] + }, + { + "id": "1722", + "type": "gene", + "text": "With chemical shift imaging , the signal intensity decreased on the out - of - phase images in six of seven ( 86 % ) patients with APA and in eight of nine ( 89 % ) patients with BAH .", + "entities": [] + }, + { + "id": "1723", + "type": "gene", + "text": "Oncogenic capacity of the E2F1 gene .", + "entities": [ + "E2F1 gene" + ] + }, + { + "id": "1724", + "type": "gene", + "text": "Immobilization of the fracture in a collar and cuff sling was as effective as more elaborate methods .", + "entities": [] + }, + { + "id": "1725", + "type": "gene", + "text": "PCR analysis indicates that this new beta - adducin isoform is expressed in fetal brain and liver , bone marrow , and NT - 2 ( neuroepithelial ) cells , but is not detected in several other tissues .", + "entities": [ + "beta - adducin isoform" + ] + }, + { + "id": "1726", + "type": "gene", + "text": "The small GTPase Rho is implicated in physiological functions associated with actin - myosin filaments such as cytokinesis , cell motility , and smooth muscle contraction .", + "entities": [ + "Rho", + "actin", + "myosin" + ] + }, + { + "id": "1727", + "type": "gene", + "text": "Green pepper significantly inhibited N - nitrosothiazolidine - carboxylic acid formation relative to ascorbic acid alone .", + "entities": [] + }, + { + "id": "1728", + "type": "gene", + "text": "We report the molecular cloning and functional characterization of USF2 isoforms , corresponding to a 44 - kDa subunit , USF2a , and a new 38 - kDa subunit , USF2b , generated by differential splicing .", + "entities": [ + "USF2 isoforms", + "USF2a", + "USF2b" + ] + }, + { + "id": "1729", + "type": "gene", + "text": "Previous studies have demonstrated that tissue - restricted transcription factors including PU . 1 and PU . 1 interaction partner ( PIP ) function synergistically with c - Fos plus c - Jun to stimulate the kappaE3 ' - enhancer in 3T3 cells .", + "entities": [ + "PU . 1", + "PU . 1 interaction partner", + "PIP", + "c - Fos", + "c - Jun", + "kappaE3 ' - enhancer" + ] + }, + { + "id": "1730", + "type": "gene", + "text": "Sulfuric acid concentration in the catalyzed breathalyzer ampules .", + "entities": [] + }, + { + "id": "1731", + "type": "gene", + "text": "OBJECTIVE - - To assess the risk of hepatitis A in international travelers and to recommend preventive measures .", + "entities": [] + }, + { + "id": "1732", + "type": "gene", + "text": "In an earlier study ( Kimura , Y . , Kurzydlowski , K . , Tada , M . , and MacLennan , D .", + "entities": [] + }, + { + "id": "1733", + "type": "gene", + "text": "We report an odd case of marked enlargement of suprapineal recess in a patient with triventricular hydrocephalus .", + "entities": [] + }, + { + "id": "1734", + "type": "gene", + "text": "PCR - derived fragments were used as probes for the isolation of the U3 snRNA genes from a genomic library of Arabidopsis .", + "entities": [ + "U3 snRNA genes" + ] + }, + { + "id": "1735", + "type": "gene", + "text": "We emphasize that ANCA - associated vasculitis is another important complication of RA .", + "entities": [ + "ANCA" + ] + }, + { + "id": "1736", + "type": "gene", + "text": "While these results are consistent with previously reported effects of the C - terminal domain on nucleotide binding , they also demonstrate that interactions with the N - terminal domains are necessary to inhibit proton transport .", + "entities": [] + }, + { + "id": "1737", + "type": "gene", + "text": "They consist of at least two separable components , one heat stable and the other heat labile .", + "entities": [] + }, + { + "id": "1738", + "type": "gene", + "text": "The ( two - motif ) domain fold contains a pair of calcium binding sites very similar to those found in a two - domain prokaryotic betagamma - crystallin fold family member , Protein S .", + "entities": [ + "two - domain prokaryotic betagamma - crystallin fold family member", + "Protein S" + ] + }, + { + "id": "1739", + "type": "gene", + "text": "Recombination between feline leukemia virus subgroup B or C and endogenous env elements alters the in vitro biological activities of the viruses .", + "entities": [ + "env" + ] + }, + { + "id": "1740", + "type": "gene", + "text": "Antibodies made against fusion protein produced by the DP1A clone reacted specifically with DP - I and - II on immunoblots .", + "entities": [ + "DP1A", + "DP - I and - II" + ] + }, + { + "id": "1741", + "type": "gene", + "text": "From these results , CBF - A is a novel CArG box - , ssDNA - and RNA - binding protein , as well as a repressive transcriptional factor .", + "entities": [ + "CBF - A", + "ssDNA - and RNA - binding protein" + ] + }, + { + "id": "1742", + "type": "gene", + "text": "Thus , Sir proteins from K . lactis have roles in both silencing and telomere length maintenance , reflecting conserved functional themes .", + "entities": [ + "Sir proteins" + ] + }, + { + "id": "1743", + "type": "gene", + "text": "Only one ADR was related definitely to ciprofloxacin therapy .", + "entities": [] + }, + { + "id": "1744", + "type": "gene", + "text": "This machine drift , which was not associated with a rise in water phantom temperature and did not consistently correlate with estimated x - ray tube heat , could result in a significant overestimation of regional cerebral blood flow ( rCBF ) for a xenon / CT rCBF protocol involving 5 - 7 sequential scans obtained at 1 - min interscan intervals .", + "entities": [] + }, + { + "id": "1745", + "type": "gene", + "text": "Upon analysis of various deletion and point - mutated variants of the human IL - 6 gene promoter coupled to a reporter gene , we screened for possible cooperating transcription factors .", + "entities": [ + "human IL - 6 gene promoter" + ] + }, + { + "id": "1746", + "type": "gene", + "text": "However , each promoter activated by IEP86 was synergistically affected by the addition of IEP72 .", + "entities": [ + "IEP86", + "IEP72" + ] + }, + { + "id": "1747", + "type": "gene", + "text": "Patients had to have adequate liver , renal , and marrow functions .", + "entities": [] + }, + { + "id": "1748", + "type": "gene", + "text": "The high selectivity of arrestins for this particular functional form of receptor ensures their timely binding and dissociation .", + "entities": [ + "arrestins" + ] + }, + { + "id": "1749", + "type": "gene", + "text": "Regression analyses showed that SOREMP dream occurrences were significantly related to the amount of REM sleep , while NREMP dream occurrences were related to arousals from NREM sleep .", + "entities": [] + }, + { + "id": "1750", + "type": "gene", + "text": "Three of these subunits are also homologous to the dimeric POR from a mesophilic archaeon , Halobacterium halobium ( 21 % identity ) .", + "entities": [ + "POR" + ] + }, + { + "id": "1751", + "type": "gene", + "text": "At a systolic blood pressure ( BP ) of 60 mmHg , C02 responsiveness was abolished , but was maintained at higher levels of BP .", + "entities": [] + }, + { + "id": "1752", + "type": "gene", + "text": "Micro high - performance liquid chromatographic system with micro precolumn and dual electrochemical detector for direct injection analysis of catecholamines in body fluids .", + "entities": [] + }, + { + "id": "1753", + "type": "gene", + "text": "Three groups of patients who had undergone subtotal thyroidectomy for Graves ' s disease , toxic multinodular goitre , or euthyroid multinodular goitre 12 to 15 years before and in whom a normal serum thyroxine ( T - 4 ) level was found were each divided into two subgroups on the basis of a normal or a raised serum thyrotrophin concentration .", + "entities": [ + "thyrotrophin" + ] + }, + { + "id": "1754", + "type": "gene", + "text": "This core sequence , along with additional nonspecific downstream nucleotides , is sufficient for partial suppression of spliceosome assembly and splicing of BPV - 1 pre - mRNAs .", + "entities": [] + }, + { + "id": "1755", + "type": "gene", + "text": "Two cDNAs encoding casein kinase - 1 have been isolated from a yeast cDNA library and termed CKI1 and CKI2 .", + "entities": [ + "casein kinase - 1", + "CKI1", + "CKI2" + ] + }, + { + "id": "1756", + "type": "gene", + "text": "A prospectively gated 2D axial sequence with velocity encoding in the craniocaudal direction in the cervical region was set at a velocity of + / - 10 cm / s .", + "entities": [] + }, + { + "id": "1757", + "type": "gene", + "text": "Stable association of U2 snRNP with the branchpoint sequence of mammalian pre - mRNAs requires binding of a non - snRNP protein to the polypyrimidine tract .", + "entities": [ + "U2 snRNP" + ] + }, + { + "id": "1758", + "type": "gene", + "text": "A concentration of 12 . 5 ppm SO2 induced a decrease from baseline values of approximately 80 % in mean MCA and of roughly 70 % in mean CBF .", + "entities": [] + }, + { + "id": "1759", + "type": "gene", + "text": "From life - table analyses of these patients , we estimated that the incidence of secondary chondrosarcoma in patients who have Ollier disease is about 25 per cent at the age of forty years , and that malignant degeneration is almost a certainty in patients who have Maffucci syndrome .", + "entities": [] + }, + { + "id": "1760", + "type": "gene", + "text": "The concentrations of C4 and C1 - INH increased with advancing stage of disease and were above normal mean values in all stages .", + "entities": [ + "C4", + "C1 - INH" + ] + }, + { + "id": "1761", + "type": "gene", + "text": "We have isolated a cosmid containing DNA that corresponds to the site of transposon insertion in 257DH4 and have localized Tn5 on an 8 . 0 kb EcoRI fragment .", + "entities": [ + "Tn5", + "8 . 0 kb EcoRI fragment" + ] + }, + { + "id": "1762", + "type": "gene", + "text": "Role of the transcription start site core region and transcription factor YY1 in Rous sarcoma virus long terminal repeat promoter activity .", + "entities": [ + "transcription factor YY1", + "Rous sarcoma virus long terminal repeat promoter" + ] + }, + { + "id": "1763", + "type": "gene", + "text": "The specific electrical resistance of the cerebrospinal fluid was measured by means of conductometry in 14 cases of meningitis purulenta , 17 cases of meningitis serosa , 10 cases of encephalitis and in 32 control subjects .", + "entities": [] + }, + { + "id": "1764", + "type": "gene", + "text": "PCR / Southern blot analysis of human kidney cDNA using primers flanking the hKID coding sequence revealed expression of a full - length mRNA and short transcripts with partial exon 1 and partial exon 4 deletions .", + "entities": [ + "hKID coding sequence" + ] + }, + { + "id": "1765", + "type": "gene", + "text": "Alterations of the 5q23 - q31 interval are frequently observed in myelodysplasia and myeloid leukemia .", + "entities": [] + }, + { + "id": "1766", + "type": "gene", + "text": "Seventy - two of 73 negative controls and all positive blocks as seen on soft tissue radiographs ( STRs ) were correctly coded ( specificity 98 . 6 % , sensitivity 100 % ) .", + "entities": [] + }, + { + "id": "1767", + "type": "gene", + "text": "Two studies assessed two types of reliability of the student Jenkins Activity Survey ( JAS ; a questionnaire measure of Type A behavior ) .", + "entities": [] + }, + { + "id": "1768", + "type": "gene", + "text": "Osteogenesis imperfecta", + "entities": [] + }, + { + "id": "1769", + "type": "gene", + "text": "Accordingly , no Ha - ras codon 12 mutations are found in the EtNU - induced mammary tumors .", + "entities": [ + "Ha - ras codon 12" + ] + }, + { + "id": "1770", + "type": "gene", + "text": "We show that IL - 6 activates JRE - IL6 through an H7 - sensitive pathway that does not involve protein kinase C , cyclic AMP - dependent kinase , Ca ( 2 + ) - or calmodulin - dependent kinases , Ras , Raf - 1 , or NF - IL6 ( C / EBP beta ) .", + "entities": [ + "IL - 6", + "JRE - IL6", + "protein kinase C", + "cyclic AMP - dependent kinase", + "Ca ( 2 + ) - or calmodulin - dependent kinases", + "Ras", + "Raf - 1", + "NF - IL6", + "C / EBP beta" + ] + }, + { + "id": "1771", + "type": "gene", + "text": "These observations link actin plaque assembly to increased cell substrate adhesion .", + "entities": [ + "actin" + ] + }, + { + "id": "1772", + "type": "gene", + "text": "The infection rate was five times greater in patients with Hickman catheters than in those with Broviac catheters ( p = 0 . 01 ) .", + "entities": [] + }, + { + "id": "1773", + "type": "gene", + "text": "Effect of aging on respiratory skeletal muscles .", + "entities": [] + }, + { + "id": "1774", + "type": "gene", + "text": "This binary repeat contains repetitive DNA elements that include LINES , SINES , medium reiteration frequency repeats , and a transposon - like element .", + "entities": [] + }, + { + "id": "1775", + "type": "gene", + "text": "Cross - reaction between a monoclonal antibody and two alpha beta T cell receptors .", + "entities": [ + "alpha beta T cell receptors" + ] + }, + { + "id": "1776", + "type": "gene", + "text": "INO2 , a regulatory gene in yeast phospholipid biosynthesis , affects nuclear segregation and bud pattern formation .", + "entities": [ + "INO2" + ] + }, + { + "id": "1777", + "type": "gene", + "text": "We have previously reported that depletion of protein kinase C by long - term treatment of B16 mouse melanoma cells with phorbol dibutyrate ( PDBu ) prevented cell density - dependent melanogenesis .", + "entities": [ + "protein kinase C" + ] + }, + { + "id": "1778", + "type": "gene", + "text": "The STE20 gene , encoding a protein kinase required for pheromone signal transduction , has recently been identified in a genetic screen for high - gene - dosage suppressors of a partly defective G beta mutation .", + "entities": [ + "STE20 gene", + "G beta" + ] + }, + { + "id": "1779", + "type": "gene", + "text": "Using an opsonophagocytic bacterial assay and a suckling rat model of GBS sepsis , we analyzed a modified human immunoglobulin for opsonic and protective antibody .", + "entities": [ + "human immunoglobulin" + ] + }, + { + "id": "1780", + "type": "gene", + "text": "Endoscopic transthoracic sympathectomy as adjuvant treatment for critical upper - limb ischaemia .", + "entities": [] + }, + { + "id": "1781", + "type": "gene", + "text": "Allagille ' s syndrome associated with antenatal ascites", + "entities": [] + }, + { + "id": "1782", + "type": "gene", + "text": "The study goals were to isolate a full - length clone encoding CO - Ag from a bovine corneal cDNA library and to express this clone in Escherichia coli ( E . coli ) .", + "entities": [ + "CO - Ag" + ] + }, + { + "id": "1783", + "type": "gene", + "text": "In all other cases , vestibular neurectomy or chemical vestibular labyrinthectomy , by means of intratympanic low concentration gentamicin ( 20 mg / mL ) , are indicated .", + "entities": [] + }, + { + "id": "1784", + "type": "gene", + "text": "To identify some of the genes expressed in LPS - activated coelomocytes , we sequenced randomly chosen clones from a directionally constructed cDNA library to produce a set of expressed sequence tags ( ESTs ) .", + "entities": [] + }, + { + "id": "1785", + "type": "gene", + "text": "These results indicate that during pregnancy there are increases in bone formation rates contributing to the increases in skeletal mass .", + "entities": [] + }, + { + "id": "1786", + "type": "gene", + "text": "Twenty - four hours later , the animals were randomized to subretinal treatment with 2 . 5 micrograms of tissue plasminogen activator or a similar volume of physiologic saline .", + "entities": [ + "tissue plasminogen activator" + ] + }, + { + "id": "1787", + "type": "gene", + "text": "Vitrectomy in ocular traumatology", + "entities": [] + }, + { + "id": "1788", + "type": "gene", + "text": "The transit time was significantly shortened .", + "entities": [] + }, + { + "id": "1789", + "type": "gene", + "text": "The concomitant interaction of mSTI1 with hsp70 and hsp90 at its N - and C - termini respectively is mediated by the tetratricopeptide repeat ( TPR ) motifs in these regions .", + "entities": [ + "mSTI1", + "hsp70", + "hsp90" + ] + }, + { + "id": "1790", + "type": "gene", + "text": "G - CSF was started on day 3 of each cycle ( 5 microg / kg / day ) and was stopped the day before the last apheresis or when absolute neutrophil count was above 0 . 5 x 10 ( 9 ) / l .", + "entities": [ + "G - CSF" + ] + }, + { + "id": "1791", + "type": "gene", + "text": "Low - dose D ( 0 . 4 - 0 . 8 mg ) and DB ( 1 . 0 - 5 . 0 mg ) did not significantly alter any parameter from control .", + "entities": [] + }, + { + "id": "1792", + "type": "gene", + "text": "In order to screen for such cofactors , we have used a transcriptionally inactive mutant of Xenopus MEF2D in a yeast two - hybrid screen .", + "entities": [ + "Xenopus MEF2D" + ] + }, + { + "id": "1793", + "type": "gene", + "text": "The DNA helix at the tandemly repeated , 13mer sequence is thermodynamically unstable , as evidenced by hypersensitivity to single - strand - specific nuclease in a negatively supercoiled plasmid , and demonstrated by stable DNA unwinding seen after two - dimensional gel electrophoresis of topoisomers .", + "entities": [ + "single - strand - specific nuclease" + ] + }, + { + "id": "1794", + "type": "gene", + "text": "On the basis of these unique properties , the newly characterized hemagglutinin has been termed Limulus 18K agglutination - aggregation factor ( 18K - LAF ) .", + "entities": [ + "hemagglutinin", + "Limulus 18K agglutination - aggregation factor", + "18K - LAF" + ] + }, + { + "id": "1795", + "type": "gene", + "text": "It can be concluded that in normotensive subjects , uric acid and xanthine oxidase have significant association with blood pressure and thus are one of the many factors which are involved in the cause or effect of hypertension .", + "entities": [ + "xanthine oxidase" + ] + }, + { + "id": "1796", + "type": "gene", + "text": "Ras p21Val inhibits myogenesis without altering the DNA binding or transcriptional activities of the myogenic basic helix - loop - helix factors .", + "entities": [ + "Ras p21Val", + "myogenic basic helix - loop - helix factors" + ] + }, + { + "id": "1797", + "type": "gene", + "text": "However , inclusion of the neighboring CGGAAR motifs from the ICP4 promoter , which bind factors GABP alpha and beta , results in a strong synergistic activation .", + "entities": [ + "ICP4 promoter", + "GABP alpha and beta" + ] + }, + { + "id": "1798", + "type": "gene", + "text": "The toxicological evaluation of chlorofluorocarbon 22 ( CFC 22 ) .", + "entities": [] + }, + { + "id": "1799", + "type": "gene", + "text": "The consensus highlights the importance of residues other than the eight motifs that are often associated with DEAD - box RNA helicases , as well as de - emphasising the importance of the \" A \" residue within the \" DEAD \" motif .", + "entities": [ + "DEAD - box RNA helicases" + ] + }, + { + "id": "1800", + "type": "gene", + "text": "RNA polymerase bound to the + 10A promoter partially protects a 20 base - pair sequence from DNase I digestion upstream of the start site .", + "entities": [ + "RNA polymerase", + "DNase I" + ] + }, + { + "id": "1801", + "type": "gene", + "text": "A single nucleotide polymorphism ( SNP ) in exon 2 , which is tightly liked to another SNP ( GTG83 / ATG83 ) , creates an additional alternative in - frame AUG in B - type MTH1 mRNAs yielding the fourth MTH1 polypeptide , p26 that possesses an additional mitochondrial targeting signal .", + "entities": [ + "B - type MTH1 mRNAs", + "MTH1 polypeptide", + "p26" + ] + }, + { + "id": "1802", + "type": "gene", + "text": "One of these is located in the 5 ' - untranslated region , and may encode regulatory sequences .", + "entities": [] + }, + { + "id": "1803", + "type": "gene", + "text": "The euglobulin clot lysis time was slightly longer in the smokers than in the non - smokers in all three experimental situations , but the differences were not significant .", + "entities": [ + "euglobulin" + ] + }, + { + "id": "1804", + "type": "gene", + "text": "In both experiments , average daily gain and gain - to - feed ratio were similar for TR and CR .", + "entities": [] + }, + { + "id": "1805", + "type": "gene", + "text": "A 3 - week regimen of erythropoietin may help prevent the donor ' s need to receive allogeneic blood transfusion , when the initial Hb levels were below 130 milligrams .", + "entities": [ + "erythropoietin", + "Hb" + ] + }, + { + "id": "1806", + "type": "gene", + "text": "Approximately 60 % of cell bodies of primary neurons innervating the intra and perioral structures through the inferior alveolar , lingual , mental , and buccal nerves were in the range between 300 and 600 micron 2 in cross - sectional area : mean + / - SD 509 + / - 243 micron 2 , 420 + / - 181 micron 2 , 469 + / - 200 micron 2 , and 444 + / - 186 micron 2 , respectively .", + "entities": [] + }, + { + "id": "1807", + "type": "gene", + "text": "Effects of diltiazem on netilmicin - induced nephrotoxicity in rabbits .", + "entities": [] + }, + { + "id": "1808", + "type": "gene", + "text": "Molecular and genetic analysis of the yeast early meiotic recombination genes REC102 and REC107 / MER2 .", + "entities": [ + "yeast early meiotic recombination genes REC102", + "REC107", + "MER2" + ] + }, + { + "id": "1809", + "type": "gene", + "text": "Such mutations are thought to exert their dominant phenotype by sequestration of the guanine nucleotide exchange factor ( GNEF ) .", + "entities": [ + "guanine nucleotide exchange factor", + "GNEF" + ] + }, + { + "id": "1810", + "type": "gene", + "text": "Like many eukaryotic transcription factors , these proteins bind to DNA as dimers .", + "entities": [] + }, + { + "id": "1811", + "type": "gene", + "text": "One linker - peptide insertion in the RsaA C terminus ( amino acid 784 ) had no effect on S - layer biogenesis , while another ( amino acid 907 ) disrupted secretion of the protein , suggesting that RsaA possesses a secretion signal lying C terminal to amino acid 784 , near or including amino acid 907 .", + "entities": [ + "RsaA C terminus ( amino acid 784 )", + "RsaA" + ] + }, + { + "id": "1812", + "type": "gene", + "text": "In regards to the latter activity , it has been shown that S3 contains vigorous N - glycosylase activity for the removal of 8 - oxoguanine residues in DNA that leaves baseless sites in their places .", + "entities": [ + "S3", + "N - glycosylase" + ] + }, + { + "id": "1813", + "type": "gene", + "text": "Concentrations of N ( O3 - ) - N and N ( H3 - ) - N at Deoprayag varied from 0 . 30 to 0 . 50 and 0 . 02 to 0 . 12 mg / L , respectively , depending on season .", + "entities": [] + }, + { + "id": "1814", + "type": "gene", + "text": "No evidence for the presence of introns within the acvA gene has been found .", + "entities": [ + "acvA gene" + ] + }, + { + "id": "1815", + "type": "gene", + "text": "In all of these cases , expression of the implicated genes was absent .", + "entities": [] + }, + { + "id": "1816", + "type": "gene", + "text": "In SN - 48 neuronal cells that express MR , GR , and 5 - HT1A receptors , deletion or inactivation of the nGRE ( negative GRE ) eliminated negative regulation of the rat 5 - HT1A or heterologous promoters by corticosteroids , whereas its inclusion conferred corticosteroid - induced inhibition to a heterologous promoter .", + "entities": [ + "MR", + "GR", + "5 - HT1A receptors", + "rat 5 - HT1A" + ] + }, + { + "id": "1817", + "type": "gene", + "text": "The weak relationships between F and Zn to Mg clearly have no significant effect on the contents of these elements in bone .", + "entities": [] + }, + { + "id": "1818", + "type": "gene", + "text": "Similarly , supraventricular tachycaydia following resuscitative efforts appeared to be associated with a negative outcome .", + "entities": [] + }, + { + "id": "1819", + "type": "gene", + "text": "SAMPLE POPULATION : MCB from 7 racing Greyhounds euthanatized for reasons unrelated to MCB abnormalities .", + "entities": [] + }, + { + "id": "1820", + "type": "gene", + "text": "Nucleotide sequencing indicates that this E1 alpha cDNA clone is 1821 base pairs ( bp ) in length with an open reading frame of 1365 bp and a 3 ' - untranslated region of 356 bp .", + "entities": [ + "E1 alpha cDNA" + ] + }, + { + "id": "1821", + "type": "gene", + "text": "Confirming measures made by nurses and additionally , ABPM for women , seem to lessen this effect .", + "entities": [] + }, + { + "id": "1822", + "type": "gene", + "text": "Based on previous mapping of the G beta gamma binding region of beta ARK , and conserved residues within the PH domain , we have constructed a series of mutants in the carboxyl terminus of beta ARK in order to determine important residues involved in G beta gamma and PIP2 binding .", + "entities": [ + "G beta gamma binding region", + "beta ARK", + "PH domain", + "beta ARK", + "G beta gamma" + ] + }, + { + "id": "1823", + "type": "gene", + "text": "After that report , carboxypeptidase D ( CPD ) was subsequently purified from bovine pituitary and characterized as a novel carboxypeptidase E ( CPE ) - like enzyme , with many characteristics in common with duck gp180 ( Song , L . , Fricker , L . D . , 1995 .", + "entities": [ + "carboxypeptidase D", + "CPD", + "carboxypeptidase E", + "CPE", + "gp180" + ] + }, + { + "id": "1824", + "type": "gene", + "text": "An examination of the role of the carboxyl terminus in regulating NGFI - B transcriptional activity revealed that , in accordance with other nuclear receptors , mutants lacking portions of the carboxyl terminus had greatly decreased activity .", + "entities": [ + "NGFI - B" + ] + }, + { + "id": "1825", + "type": "gene", + "text": "The IE13 . 1 cell line was able to complement a recombinant virus in which both copies of the IE gene were replaced by insertion of the Escherichia coli lacZ gene .", + "entities": [ + "IE gene", + "Escherichia coli lacZ gene" + ] + }, + { + "id": "1826", + "type": "gene", + "text": "Effect of acute and chronic psychogenic stress on corticoadrenal and pituitary - thyroid hormones in male rats .", + "entities": [ + "pituitary - thyroid hormones" + ] + }, + { + "id": "1827", + "type": "gene", + "text": "CONCLUSION : Some Gulf War veterans may have delayed , chronic neurotoxic syndromes from wartime exposure to combinations of chemicals that inhibit butyrylcholinesterase and neuropathy target esterase .", + "entities": [ + "butyrylcholinesterase", + "neuropathy target esterase" + ] + }, + { + "id": "1828", + "type": "gene", + "text": "The detection ratio peaked at ages 30 to 34 and decreased heavily during the next 15 years of age .", + "entities": [] + }, + { + "id": "1829", + "type": "gene", + "text": "Constitutive phosphorylation and nuclear localization of Smad3 are correlated with increased collagen gene transcription in activated hepatic stellate cells .", + "entities": [ + "Smad3", + "collagen gene" + ] + }, + { + "id": "1830", + "type": "gene", + "text": "The unfolded protein response regulates multiple aspects of secretory and membrane protein biogenesis and endoplasmic reticulum quality control .", + "entities": [] + }, + { + "id": "1831", + "type": "gene", + "text": "Spc42p also was identified as a component of a cytoplasmic SPB subcomplex containing Spc94p / Nud1p , Cnm67p , and Spc42p .", + "entities": [ + "Spc42p", + "Spc94p", + "Nud1p", + "Cnm67p", + "Spc42p" + ] + }, + { + "id": "1832", + "type": "gene", + "text": "During conventional hemofiltration using substitution fluid with a Na + concentration of 140 mEq / L , a decrease in extracellular fluid volume was noted whereas the intracellular fluid volume was unaltered .", + "entities": [] + }, + { + "id": "1833", + "type": "gene", + "text": "High values of both retinol and beta - carotene were found in full fat cheeses and whipping cream : from 179 . 0 ( cheese , Edam - type ) to 318 . 7 micrograms / 100 g ( whipping cream ) and from 86 . 7 ( cheese , Edam - type ) to 186 . 5 micrograms / 100 g ( whipping cream ) for all - trans retinol and total beta - carotene , respectively .", + "entities": [] + }, + { + "id": "1834", + "type": "gene", + "text": "A further study on plasminogen activator release by vasoactive agents in the isolated perfused dog leg .", + "entities": [ + "plasminogen activator" + ] + }, + { + "id": "1835", + "type": "gene", + "text": "Therefore , we suggested that both proteins might belong to the PLTP family .", + "entities": [ + "PLTP family" + ] + }, + { + "id": "1836", + "type": "gene", + "text": "Pathology of neuritis caudae equinae in the horse", + "entities": [] + }, + { + "id": "1837", + "type": "gene", + "text": "We present the preliminary results obtained on 36 patients which were followed for a mean period of 12 months .", + "entities": [] + }, + { + "id": "1838", + "type": "gene", + "text": "CREB was identified as one of the protein components in several of the gel shift complexes formed with the variant CRE .", + "entities": [ + "CREB" + ] + }, + { + "id": "1839", + "type": "gene", + "text": "Molecular structure and evolutionary origin of human cardiac muscle actin gene .", + "entities": [ + "human cardiac muscle actin gene" + ] + }, + { + "id": "1840", + "type": "gene", + "text": "There was no competition between activin A and OP - 1 for availability of Smad4 , indicating that the concentration of this common signal transducer is not limiting for generating the observed biological responses .", + "entities": [ + "activin A", + "OP - 1", + "Smad4" + ] + }, + { + "id": "1841", + "type": "gene", + "text": "Molecular cloning of mouse glycolate oxidase .", + "entities": [ + "mouse glycolate oxidase" + ] + }, + { + "id": "1842", + "type": "gene", + "text": "Cytomegalovirus , Chlamydia pneumoniae , and Helicobacter pylori IgG antibodies and restenosis after stent implantation : an angiographic and intravascular ultrasound study .", + "entities": [ + "IgG antibodies" + ] + }, + { + "id": "1843", + "type": "gene", + "text": "A platelet - derived growth factor receptor ( PDGF - R ) phosphopeptide containing Tyr - 857 does not bind appreciably to the Src SH2 domain , suggesting it is not the PDGF - R binding site for Src as previously reported .", + "entities": [ + "platelet - derived growth factor receptor", + "PDGF - R", + "Src SH2 domain", + "PDGF - R", + "Src" + ] + }, + { + "id": "1844", + "type": "gene", + "text": "Losses during the complete procedure are corrected for using radioactive estrogen conjugates during the first steps and later by adding deuterated internal standards of all compounds measured ( matairesinol , enterodiol , enterolactone , daidzein , O - desmethylangolensin , equol , and genistein ) .", + "entities": [] + }, + { + "id": "1845", + "type": "gene", + "text": "The response properties of cat horizontal canal afferents ( N = 81 ) were characterized by three parameters : their long time constants ( tau ) , low frequency gain constants ( G1 ) , and middle frequency gain constants ( Gm ) .", + "entities": [] + }, + { + "id": "1846", + "type": "gene", + "text": "We propose that noi / pax2 . 1 participates in sequential signaling processes as a key integrator of midbrain - hindbrain boundary development .", + "entities": [ + "noi", + "pax2 . 1" + ] + }, + { + "id": "1847", + "type": "gene", + "text": "We conclude that grade III BGCT can be treated by modified intralesional excision provided the articular surfaces and part of the metaphysis are intact .", + "entities": [] + }, + { + "id": "1848", + "type": "gene", + "text": "10 . 0 + / - 2 . 0 pmol / 24 h , P < 0 . 01 ) and remained elevated .", + "entities": [] + }, + { + "id": "1849", + "type": "gene", + "text": "A DNA fragment carrying 1 , 100 nucleotides derived from the 5 ' - flanking region of the UGT1A1 gene was enough for MC induction .", + "entities": [ + "UGT1A1 gene" + ] + }, + { + "id": "1850", + "type": "gene", + "text": "The interferon - inducible protein kinase PKR modulates the transcriptional activation of immunoglobulin kappa gene .", + "entities": [ + "interferon", + "protein kinase PKR", + "immunoglobulin kappa gene" + ] + }, + { + "id": "1851", + "type": "gene", + "text": "Ultrasonic evaluation of renal calculi .", + "entities": [] + }, + { + "id": "1852", + "type": "gene", + "text": "Despite an overall survival rate of 43 % , survival to discharge varied greatly ( 0 to 100 % ) among the 24 diagnostic groups : tumor lysis syndrome and systemic lupus erythematosus ( 3 / 3 patients each , 100 % ) , hemolytic uremic syndrome ( 8 / 9 patients , 89 % ) .", + "entities": [] + }, + { + "id": "1853", + "type": "gene", + "text": "Our study differs from previous studies in that it is limited to one diagnostic entity , yet at the same time evaluates a broad range of social and work - related factors in disability .", + "entities": [] + }, + { + "id": "1854", + "type": "gene", + "text": "The frameshift initiated by ADEx2 is believed to alter the regular coding sequence , acting as a loss - of - function ASIP mutation .", + "entities": [ + "ASIP mutation" + ] + }, + { + "id": "1855", + "type": "gene", + "text": "This promoter could direct the constitutive expression of the reporter beta - galactosidase at high frequency in transfected colonies of transformed cells that express L - plastin constitutively ; by contrast , this promoter was virtually inactive in transfected colonies of normal fibroblasts and it exhibited a low frequency of constitutive activation in transfected colonies of in vitro SV40 - transformed fibroblasts which did not exhibit L - plastin expression .", + "entities": [ + "beta - galactosidase", + "L - plastin", + "L - plastin" + ] + }, + { + "id": "1856", + "type": "gene", + "text": "Mutation of the central Tyr497 to Phe blocks the tyrosine phosphorylation of the insulin receptor substrate 1 ( IRS1 ) and diminishes proliferation in response to IL - 4 .", + "entities": [ + "insulin receptor substrate 1", + "IRS1", + "IL - 4" + ] + }, + { + "id": "1857", + "type": "gene", + "text": "This study was aimed at assessing whether c - DDP administration immediately before radiotherapy could increase frequency and duration of objective responses , as well as survival , in patients affected with locally advanced stages of squamous carcinomas of the head and neck .", + "entities": [] + }, + { + "id": "1858", + "type": "gene", + "text": "A 2 years and 9 months old female patient , with the diagnosis of Weaver syndrome is reported .", + "entities": [] + }, + { + "id": "1859", + "type": "gene", + "text": "This indicates that recruitment of large T antigen to the rRNA promoter by SL1 constitutes a crucial step in the activation process .", + "entities": [ + "large T antigen", + "SL1" + ] + }, + { + "id": "1860", + "type": "gene", + "text": "The peptide sequences reveal that the factor consists of GABP alpha and GABP beta 1 with Ets and Notch motifs , respectively .", + "entities": [ + "GABP alpha", + "GABP beta 1", + "Ets", + "Notch motifs" + ] + }, + { + "id": "1861", + "type": "gene", + "text": "In an in vitro study , 10 / 0 nylon was found to require a significantly lower laser energy density to produce suture lysis following a single shot than either 10 / 0 Dacron or 10 / 0 prolene .", + "entities": [] + }, + { + "id": "1862", + "type": "gene", + "text": "In comparison with normal pregnant women and normal non - pregnant women , women with PIH showed an increase in heart rate , suggesting an increased peripheral sympathetic tone , and an initial derangement in renal function as shown by the increase in serum uric acid and reduction in sodium excretion and total and fractional calcium excretion at any given level of sodium excretion .", + "entities": [] + }, + { + "id": "1863", + "type": "gene", + "text": "Our results suggest that Lrp binds a central palindromic site , interacting predominantly with the major groove of its DNA target , and that additional dimers bind to flanking sites to form a nucleoprotein activation complex .", + "entities": [ + "Lrp" + ] + }, + { + "id": "1864", + "type": "gene", + "text": "Platelet aggregation and metabolic control are not affected by calcium antagonist treatment in type II diabetes mellitus .", + "entities": [] + }, + { + "id": "1865", + "type": "gene", + "text": "However , the few studies that address antimicrobial prophylaxis in bone marrow transplantation have not always shown a survival benefit .", + "entities": [] + }, + { + "id": "1866", + "type": "gene", + "text": "However , the favored , parallel beta helix model is a compact coil of ten helically arranged beta strands forming two parallel beta sheet faces .", + "entities": [] + }, + { + "id": "1867", + "type": "gene", + "text": "Study on micromelias in the mouse fetus caused by x - radiation , hypoxia , trypan blue injection of hypervitaminosis - A upon mother animals during pregnancy .", + "entities": [] + }, + { + "id": "1868", + "type": "gene", + "text": "In addition , depletion of Oct - 1 from the nuclear extract by using Oct - 1 - specific antiserum or a sequence - specific DNA affinity resin decreased in vitro transcription from the wild - type MMTV promoter to a level identical to that obtained from a promoter in which all three octamer - related sequences were mutated .", + "entities": [ + "Oct - 1", + "Oct - 1" + ] + }, + { + "id": "1869", + "type": "gene", + "text": "Expression of activated Cdc42 results in the translocation of PKClambda from the nucleus into the cytosol , and Cdc42 and PKClambda colocalize at the plasma membrane and in the cytoplasm .", + "entities": [ + "Cdc42", + "PKClambda", + "Cdc42", + "PKClambda" + ] + }, + { + "id": "1870", + "type": "gene", + "text": "Within the human enhancer , these two sites are located within the previously defined DNase I footprints , NFAT - 1 and NFIL - 2B , respectively .", + "entities": [ + "DNase I footprints", + "NFAT - 1", + "NFIL - 2B" + ] + }, + { + "id": "1871", + "type": "gene", + "text": "In order to characterize the functional elements of the promoter that in some way must respond to these regulatory signals , a number of promoter mutations were constructed , including a set of linker - scanning mutations across the entire promoter region .", + "entities": [] + }, + { + "id": "1872", + "type": "gene", + "text": "ECM disruption in Lytechinus embryos caused a relative drop in USF RNA accumulation levels to approximately 60 % of control embryos , while LpS1 RNA accumulation levels dropped to less than 5 % .", + "entities": [ + "USF RNA", + "LpS1 RNA" + ] + }, + { + "id": "1873", + "type": "gene", + "text": "In recent years , successful physiological models have been developed for a variety of volatile and nonvolatile chemicals , and their ability to perform the extrapolations needed in risk assessment has been demonstrated .", + "entities": [] + }, + { + "id": "1874", + "type": "gene", + "text": "This repression does not require the PU . 1 transactivation or PEST domains and cannot be reversed by p300 expression .", + "entities": [ + "PU . 1", + "p300" + ] + }, + { + "id": "1875", + "type": "gene", + "text": "Confocal fluorescence microscopy in modern cell biology .", + "entities": [] + }, + { + "id": "1876", + "type": "gene", + "text": "These results show that the CAAT - region is involved in upregulating the MDR1 promoter in HL60 / VCR cells .", + "entities": [ + "MDR1 promoter" + ] + }, + { + "id": "1877", + "type": "gene", + "text": "Autoimmune manipulation aids juvenile diabetes management .", + "entities": [] + }, + { + "id": "1878", + "type": "gene", + "text": "Reconstitution of Raf - 1 activity was observed only with kinase active Jak1 in both cell lines .", + "entities": [ + "Raf - 1", + "Jak1" + ] + }, + { + "id": "1879", + "type": "gene", + "text": "Biol .", + "entities": [] + }, + { + "id": "1880", + "type": "gene", + "text": "Eight of 14 infectious or inflammatory lesions could be detected in the early scan ( 4 - 6 h p . i . ) .", + "entities": [] + }, + { + "id": "1881", + "type": "gene", + "text": "Using this method , we were able to select strong enhancer - type activation domains from the immediate early regions of two herpesviruses , namely pseudorabies virus and bovine herpesvirus 1 .", + "entities": [ + "immediate early regions" + ] + }, + { + "id": "1882", + "type": "gene", + "text": "LysR proteins have been shown to regulate urease in Klebsiella aerogenes ( NAC ) , and catalase in Escherichia coli ( OxyR ) , which offers the intracellular bacterium protection from phagolysosome damage .", + "entities": [ + "LysR proteins", + "urease in Klebsiella aerogenes", + "NAC", + "catalase in Escherichia coli", + "OxyR" + ] + }, + { + "id": "1883", + "type": "gene", + "text": "PATIENTS AND METHODS : Semen analyses were performed on 58 patients with stages I - III HD before , during , and after chemotherapy and after the sperm count recovered from the effects of abdominal radiotherapy that was given after chemotherapy .", + "entities": [] + }, + { + "id": "1884", + "type": "gene", + "text": "220 , 263 - 273 ) .", + "entities": [] + }, + { + "id": "1885", + "type": "gene", + "text": "Substitution of the DR1 beta chain with H - 2E beta k led to a dramatic loss of recognition ; alpha chain substitution had a less marked effect .", + "entities": [ + "DR1 beta chain", + "H - 2E beta k" + ] + }, + { + "id": "1886", + "type": "gene", + "text": "One hundred and four ( 14 per cent ) second primary tumours were reported .", + "entities": [] + }, + { + "id": "1887", + "type": "gene", + "text": "After surgery , patients self administered one of three possible postsurgical medications , which included placebo , codeine 60 mg , and ibuprofen 400 mg , when their pain reached a moderate or severe intensity .", + "entities": [] + }, + { + "id": "1888", + "type": "gene", + "text": "Successive abdominal scintillation with 131 - I - tagged BSP - - description of the thyroid gland , kidney and spleen ( comparison with 131 - I - RB )", + "entities": [] + }, + { + "id": "1889", + "type": "gene", + "text": "VP - 16 , ifosfamide and cisplatin ( VIP ) for extensive small cell lung cancer .", + "entities": [] + }, + { + "id": "1890", + "type": "gene", + "text": "Purified Hsk1 phosphorylates the Cdc19 ( Mcm2 ) subunit of the six - member minichromosome maintenance protein complex purified from fission yeast .", + "entities": [ + "Hsk1", + "Cdc19", + "Mcm2", + "six - member minichromosome maintenance protein complex" + ] + }, + { + "id": "1891", + "type": "gene", + "text": "This distribution implies that the polycistronic precursor is imported into the nucleolus for processing to the mature snoRNAs , and that the import or processing pathway involves coiled bodies .", + "entities": [] + }, + { + "id": "1892", + "type": "gene", + "text": "A highly significant correlation was found between the presence of fibrinolytic degradation products ( FDP ) and the incidence of nephropathy and renal insufficiency , as well as between the presence of fibrin monomers ( Godal ' s ethanol - gelification test ) and the evolutive signs of the primary disease ( fever , accelerated ESR ) .", + "entities": [ + "fibrin monomers" + ] + }, + { + "id": "1893", + "type": "gene", + "text": "The kinase is essential in vivo for normal phosphorylation of the CTD and for normal growth and differentiation .", + "entities": [] + }, + { + "id": "1894", + "type": "gene", + "text": "The maintenance of increased myocardial capillary density required a similar amount of exercise , and at least 1 h of exercise once a week was necessary to maintain the enlargement of ECA . 20", + "entities": [] + }, + { + "id": "1895", + "type": "gene", + "text": "Transient co - transfection assays involving NFKB2 expression vectors and kappa B - driven reporter plasmids indicate that NFKB2 p85 has lost the transcriptional repressor functions typical of normal NFKB2 p52 .", + "entities": [ + "NFKB2", + "kappa B", + "p85", + "p52" + ] + }, + { + "id": "1896", + "type": "gene", + "text": "Relationship of CDK - activating kinase and RNA polymerase II CTD kinase TFIIH / TFIIK .", + "entities": [ + "CDK - activating kinase", + "RNA polymerase II", + "TFIIH", + "TFIIK" + ] + }, + { + "id": "1897", + "type": "gene", + "text": "Extracellular fibril formation by neuroglial cells at the vitreoretinal junction of the human eye .", + "entities": [] + }, + { + "id": "1898", + "type": "gene", + "text": "The region of plasmid pCM2 encoding the pathogenicity locus pat - 1 was mapped by deletion analysis and complementation studies to a 1 . 5 - kb Bg / II / SmaI DNA fragment .", + "entities": [ + "pathogenicity locus pat - 1", + "Bg / II", + "SmaI" + ] + }, + { + "id": "1899", + "type": "gene", + "text": "The predicted protein , Seb1p , consists of 82 amino acids and contains one potential membrane - spanning region at the C - terminus but no N - terminal signal sequence .", + "entities": [ + "Seb1p" + ] + }, + { + "id": "1900", + "type": "gene", + "text": "No significant differences were found between the TS and the PTS .", + "entities": [] + }, + { + "id": "1901", + "type": "gene", + "text": "The latency time for the lactate concentration to reach the top values was reduced by aerobic training ( T2 ) .", + "entities": [] + }, + { + "id": "1902", + "type": "gene", + "text": "The brackets were bonded to 100 freshly extracted bovine incisors , and , after storage in tap water at room temperature for 24 hours , they were subsequently tested in a shear mode using a universal testing machine .", + "entities": [] + }, + { + "id": "1903", + "type": "gene", + "text": "In three cases ( 21 . 4 % ) , the MR imaging was interpreted as negative , but microscopic tumor was shown around seroma on reexcision .", + "entities": [] + }, + { + "id": "1904", + "type": "gene", + "text": "Expression of various FAK mutants in the FAK - cells showed that FAK kinase activity , the Tyr - 397 / SH2 domain binding site , and the first proline - rich SH3 binding region in the FAK C - terminal domain were individually needed to promote full FAK - mediated FAK - cell migration to FN whereas direct paxillin binding to FAK was not required .", + "entities": [ + "FAK mutants", + "FAK", + "FAK kinase", + "Tyr - 397 / SH2 domain binding site", + "SH3 binding region", + "FAK C - terminal domain", + "FAK", + "FAK", + "FN", + "paxillin", + "FAK" + ] + }, + { + "id": "1905", + "type": "gene", + "text": "False positive PET FDG corresponded to lung infection , degenerative bone disease , and reconstruction artifact .", + "entities": [] + }, + { + "id": "1906", + "type": "gene", + "text": "Transition between P - and H - BPPV was found in 6 cases .", + "entities": [] + }, + { + "id": "1907", + "type": "gene", + "text": "The transmembrane topology of Na ( + ) / H ( + ) exchanger NHE3 has been studied using in vitro transcription / translation of two types of fusion vectors designed to test membrane insertion properties of cDNA sequences encoding putative NHE3 membrane spanning domains ( msds ) .", + "entities": [ + "NHE3", + "NHE3" + ] + }, + { + "id": "1908", + "type": "gene", + "text": "The same rhythmic structure enables a prediction to be made concerning when vowels of stressed syllables will be auditorily perceived .", + "entities": [] + }, + { + "id": "1909", + "type": "gene", + "text": "Recently , extremely high levels of endothelin - 1 ( ET - 1 ) were detected in the pericardial fluid of patients undergoing cardiac surgery .", + "entities": [ + "endothelin - 1", + "ET - 1" + ] + }, + { + "id": "1910", + "type": "gene", + "text": "Such multisensory interactions can be significant for behavior .", + "entities": [] + }, + { + "id": "1911", + "type": "gene", + "text": "In addition , IgM can be absent in children with congenital toxoplasmosis or subjects with secondary reactivation .", + "entities": [ + "IgM" + ] + }, + { + "id": "1912", + "type": "gene", + "text": "Glutamyl - tRNA synthetase and prolyl - tRNA synthetase belong to different classes of aminoacyl - tRNA synthetases that are thought to have evolved along independent evolutionary pathways .", + "entities": [ + "Glutamyl - tRNA synthetase", + "prolyl - tRNA synthetase", + "aminoacyl - tRNA synthetases" + ] + }, + { + "id": "1913", + "type": "gene", + "text": "Biol .", + "entities": [] + }, + { + "id": "1914", + "type": "gene", + "text": "Following the patients during a course of therapy with a selective vasodilator calcium antagonist , the beta - adrenergic reflex vasodilation became substantially attenuated but was preserved during a placebo course of therapy .", + "entities": [] + }, + { + "id": "1915", + "type": "gene", + "text": "Further analysis of this DNA fragment showed that four genes are present encoding proteins of 16 , 18 . 5 , 21 and 89 kDal .", + "entities": [] + }, + { + "id": "1916", + "type": "gene", + "text": "Acute type A hepatitis in three patients with chronic HBV infection .", + "entities": [] + }, + { + "id": "1917", + "type": "gene", + "text": "Its transcription has been shown to be induced 40 - 50 - fold in response to oxygen or heme deficiency , in part through relief of repression exerted by Rox1p and in part by activation mediated by an upstream activation sequence ( UAS ) .", + "entities": [ + "Rox1p" + ] + }, + { + "id": "1918", + "type": "gene", + "text": "Expression of thiamin biosynthetic genes ( thiCOGE ) and production of symbiotic terminal oxidase cbb3 in Rhizobium etli .", + "entities": [ + "thiCOGE", + "symbiotic terminal oxidase cbb3" + ] + }, + { + "id": "1919", + "type": "gene", + "text": "The results obtained are similar to those described with the previous Cremophor formulation although greater variability in induction and recovery times was noted with the emulsion formulation .", + "entities": [] + }, + { + "id": "1920", + "type": "gene", + "text": "Roux - en - Y gastroenterostomy severely disturbs emptying of the gallbladder .", + "entities": [] + }, + { + "id": "1921", + "type": "gene", + "text": "The bactericidal effect of disinfectants against biofilm cells was found to be considerably enhanced by increasing the concentrations of the disinfectants .", + "entities": [] + }, + { + "id": "1922", + "type": "gene", + "text": "To evaluate the cost and benefits of screening tests for Chlamydia trachomatis in adolescent males , we developed a decision analysis model and compared the leukocyte esterase urine dipstick test with culture , with direct - smear fluorescent antibody ( DFA ) , and with the option of no screening ( no treatment ) .", + "entities": [ + "leukocyte esterase" + ] + }, + { + "id": "1923", + "type": "gene", + "text": "There were 122 cases of tuberculosis over an average 10 . 3 yr of follow - up ( crude annual incidence , 76 . 2 / 100 , 000 ) .", + "entities": [] + }, + { + "id": "1924", + "type": "gene", + "text": "We have examined the role of two recombination - and repair - defective mutations , rad1 and rad52 , on direct repeat recombination in transcriptionally active and inactive sequences .", + "entities": [ + "rad1", + "rad52" + ] + }, + { + "id": "1925", + "type": "gene", + "text": "The Caenorhabditis elegans death susceptibility gene , ced - 3 , has a number of homologs in vertebrate species , including interleukin - 1 beta ( IL - 1 beta ) - converting enzyme ( ICE ) , Ich - 1long , and CPP32 .", + "entities": [ + "Caenorhabditis elegans death susceptibility gene", + "ced - 3", + "interleukin - 1 beta ( IL - 1 beta ) - converting enzyme", + "ICE", + "Ich - 1long", + "CPP32" + ] + }, + { + "id": "1926", + "type": "gene", + "text": "Our results establish GKLF as a sequence - specific transcription factor likely involved in regulation of expression of endogenous genes .", + "entities": [ + "GKLF" + ] + }, + { + "id": "1927", + "type": "gene", + "text": "Experiments with epitope - tagged proteins show that UEV1A is a nuclear protein , whereas both Kua and Kua - UEV localize to cytoplasmic structures , indicating that the Kua domain determines the cytoplasmic localization of Kua - UEV .", + "entities": [ + "UEV1A", + "Kua", + "Kua", + "UEV", + "Kua domain", + "Kua", + "UEV" + ] + }, + { + "id": "1928", + "type": "gene", + "text": "Mn2 + increased both the junction binding and cleaving activities of the mutant proteins .", + "entities": [] + }, + { + "id": "1929", + "type": "gene", + "text": "At the genomic level , the sequences of two members of this family are known in the rat Rattus norvegicus : the VCSA1 gene , encoding the prohormone - like polypeptide SMR1 , and the VCSB1 gene , encoding a salivary Pro - rich polypeptide .", + "entities": [ + "VCSA1 gene", + "prohormone - like polypeptide SMR1", + "VCSB1 gene" + ] + }, + { + "id": "1930", + "type": "gene", + "text": "It was not possible to study the basis for tissue - specific expression of this gene , because the beta 3 gene promoter had not been isolated previously .", + "entities": [ + "beta 3 gene promoter" + ] + }, + { + "id": "1931", + "type": "gene", + "text": "We have developed a rAAV - mediated gene transfer system for the rat preproinsulin II gene .", + "entities": [ + "rat preproinsulin II gene" + ] + }, + { + "id": "1932", + "type": "gene", + "text": "No significant differences could be seen in response rates according to the concentration of estrogen receptors or presence of progesteron receptors in this group of patients .", + "entities": [ + "estrogen receptors", + "progesteron receptors" + ] + }, + { + "id": "1933", + "type": "gene", + "text": "These results suggested the possibility that the fetus played some role in the production of E3 - 16 - G in early pregnancy .", + "entities": [] + }, + { + "id": "1934", + "type": "gene", + "text": "Serine 528 is phosphorylated in vivo in several cell lines , and substitution of serine 528 to alanine ( S528A ) resulted in an increased ability of Myb to transactivate a synthetic promoter containing five copies of the mim - 1A Myb - responsive element and a minimal herpes tk promoter .", + "entities": [ + "Myb", + "Myb", + "herpes tk promoter" + ] + }, + { + "id": "1935", + "type": "gene", + "text": "Viral cell - to - cell movement of PVX CP mutant was complemented in Nicotiana tabacum cv .", + "entities": [ + "PVX CP mutant" + ] + }, + { + "id": "1936", + "type": "gene", + "text": "Karger AG , Basel", + "entities": [] + }, + { + "id": "1937", + "type": "gene", + "text": "The MPS1 open reading frame has been fused to those that encode the LexA protein or the GST protein and both of these constructs function in yeast .", + "entities": [ + "MPS1 open reading frame", + "LexA protein", + "GST protein" + ] + }, + { + "id": "1938", + "type": "gene", + "text": "We investigated the diagnostic value of a new in vitro test , Pharmacia CAP System ( Pharmacia Diagnostics AB , Uppsala , Sweden ) , for the quantitative measurement of allergen - specific IgE antibodies by comparison with RAST in 2 groups of patients , 71 atopic and 48 non - atopic .", + "entities": [ + "allergen - specific IgE antibodies" + ] + }, + { + "id": "1939", + "type": "gene", + "text": "Identification of eotaxin - 3 will further promote our understanding of the control of eosinophil trafficking and other CCR3 - mediated biological phenomena .", + "entities": [ + "eotaxin - 3", + "CCR3" + ] + }, + { + "id": "1940", + "type": "gene", + "text": "Heating cells to 43 degrees C decreased the amount of newly synthesized rRNA to less than 5 % of the control level and led to greater than 95 % inhibition of transcription termination at a region 355 to 362 nucleotides downstream of the 3 ' end of 28S rRNA , with readthrough continuing into the next transcription unit .", + "entities": [ + "28S rRNA" + ] + }, + { + "id": "1941", + "type": "gene", + "text": "All loci have a similar organization , except for H1 . 8 that harbors two TcP2beta genes arranged in tandem and separated by a short repetitive sequence , named SIRE ( short interspersed repetitive element ) , which is also found upstream of the first gene of the tandem and downstream of the second .", + "entities": [ + "H1 . 8", + "TcP2beta genes" + ] + }, + { + "id": "1942", + "type": "gene", + "text": "Further , the ability of recombinant beta and / or gamma chains to function in defined biochemical assays of beta gamma activity was assessed for membrane extracts and supernatant fractions from infected Sf9 cells .", + "entities": [] + }, + { + "id": "1943", + "type": "gene", + "text": "Recent studies have shown the rat larynx to be an important organ in the evaluation of irritancy of inhaled materials .", + "entities": [] + }, + { + "id": "1944", + "type": "gene", + "text": "The transcription factor CHOP / GADD153 gene is induced by cellular stress and is involved in mediating apoptosis .", + "entities": [ + "CHOP", + "GADD153" + ] + }, + { + "id": "1945", + "type": "gene", + "text": "Patients with psychotropic drugs showed significantly higher PRL levels .", + "entities": [ + "PRL" + ] + }, + { + "id": "1946", + "type": "gene", + "text": "Max was constantly transcribed at a relatively low level during cell cycle progression .", + "entities": [ + "Max" + ] + }, + { + "id": "1947", + "type": "gene", + "text": "Patients with apparently minor CT abnormalities may have significant epidural disease .", + "entities": [] + }, + { + "id": "1948", + "type": "gene", + "text": "Varieties of envious experience .", + "entities": [] + }, + { + "id": "1949", + "type": "gene", + "text": "It is possible that the patch determines the proper conformation of the site and thereby contributes to recognition indirectly .", + "entities": [] + }, + { + "id": "1950", + "type": "gene", + "text": "Model predictions were in accord with the nine - year survival experience of women in the HIP trial , and , with the exception of women 40 - 44 years old , with HIP data on 18 - year survival .", + "entities": [] + }, + { + "id": "1951", + "type": "gene", + "text": "Measurements were done with a commercial haematofluorometer Buchler ZF which was calibrated to the average haematocrit value of 0 . 42 .", + "entities": [] + }, + { + "id": "1952", + "type": "gene", + "text": "Fifty - seven patients aged < 55 years with acute lymphoblastic leukemia ( ALL ) in second or third bone marrow ( BM ) relapse or refractory to first - line therapy were enrolled in an Italian cooperative study .", + "entities": [] + }, + { + "id": "1953", + "type": "gene", + "text": "Organisms were not observed in the 5 bobcats trapped in 2 other counties .", + "entities": [] + }, + { + "id": "1954", + "type": "gene", + "text": "Workers with \" sensitivity \" to toluene diisocyanate ( TDI ) studied in depth in an attempt to determine mechanisms of bronchial hyperreactivity .", + "entities": [] + }, + { + "id": "1955", + "type": "gene", + "text": "Induction requires the ACE1 gene product , which binds to specific sites in the promoter region of the CUP1 gene .", + "entities": [ + "ACE1 gene product", + "CUP1 gene" + ] + }, + { + "id": "1956", + "type": "gene", + "text": "During the 1980 ' s , quantifications of immunoserological testings , especially C reactive protein , rheumatoid factor and antistreptolysin O , progressed rapidly .", + "entities": [ + "C reactive protein", + "rheumatoid factor", + "antistreptolysin O" + ] + }, + { + "id": "1957", + "type": "gene", + "text": "D .", + "entities": [] + }, + { + "id": "1958", + "type": "gene", + "text": "Although no Rh - antibodies were demonstrable , a similar mechanism can be postulated for the Rh - system .", + "entities": [ + "Rh - antibodies" + ] + }, + { + "id": "1959", + "type": "gene", + "text": "They include genes encoding three subunits of the cytochrome oxidase ( cox1 to 3 ) , apocytochrome b ( cob ) , seven subunits of the NADH dehydrogenase complex ( nad1 to 6 , nad4L ) , two ATPase subunits ( atp6 and atp9 ) , three ribosomal RNAs ( rrn5 , srn and lrn ) , 23 tRNAs and four ribosomal proteins ( rps3 , rps11 , rps12 and rpl16 ) .", + "entities": [ + "cytochrome oxidase", + "cox1 to 3", + "apocytochrome b", + "cob", + "NADH dehydrogenase complex", + "nad1 to 6", + "nad4L", + "ATPase", + "atp6", + "atp9", + "rrn5", + "srn", + "lrn", + "rps3", + "rps11", + "rps12", + "rpl16" + ] + }, + { + "id": "1960", + "type": "gene", + "text": "Mutating the E - box in the context of the 3 ' - flanking region confirmed that it contributes to the enhancement of transcriptional activity of the alpha1 ( I ) collagen gene promoter .", + "entities": [ + "alpha1 ( I ) collagen gene promoter" + ] + }, + { + "id": "1961", + "type": "gene", + "text": "The average birth mass of these newborns was 3491 . 9 + / - 2 SD 780 . 5 g and that in the control group 3 , 767 . 5 + / - 2 SD 824 . 2 g ( P less than 0 . 05 ) .", + "entities": [] + }, + { + "id": "1962", + "type": "gene", + "text": "Further observations on resorption in guinea pigs following injections of trypan blue .", + "entities": [] + }, + { + "id": "1963", + "type": "gene", + "text": "Endotoxemia induced by gram - negative bacteria leads to endotoxic shock pathogenetically stemming from the integral component of the bacterial wall - - lipid A .", + "entities": [] + }, + { + "id": "1964", + "type": "gene", + "text": "We conclude that the conservation of nucleotides 154 to 156 is likely to be a consequence of their role as a sequence - specific recognition element for the SRP54 protein .", + "entities": [ + "SRP54 protein" + ] + }, + { + "id": "1965", + "type": "gene", + "text": "The indications for its use include every primary and secondary rhinoplasty candidate unless tip grafts are going to be under tension or if the deformity is minor .", + "entities": [] + }, + { + "id": "1966", + "type": "gene", + "text": "Cardiac output ( CO ) was significantly higher ( p less than 0 . 0005 ) in the MBBF group .", + "entities": [] + }, + { + "id": "1967", + "type": "gene", + "text": "Rabbit skeletal muscle glycogenin .", + "entities": [ + "Rabbit skeletal muscle glycogenin" + ] + }, + { + "id": "1968", + "type": "gene", + "text": "After i . v . administration of 500 mg acetazolamide and disinfection of the conjunctiva , 50 micrograms rt - PA in 0 . 1 ml ( BSS ) and 0 . 5 ml SF6 were injected intravitreally .", + "entities": [ + "rt - PA" + ] + }, + { + "id": "1969", + "type": "gene", + "text": "At least some of the difference in stability of the two kinds of complexes was due to the fact that the dissociation rate of the A stem substrate from the protein - DNA complexes was approximately fourfold faster than that of the complete TR .", + "entities": [ + "TR" + ] + }, + { + "id": "1970", + "type": "gene", + "text": "An interaction screen with the repression domain of the orphan receptor RevErb identified N - CoR , the corepressor for thyroid hormone receptor ( TR ) and retinoic acid receptor ( RAR ) .", + "entities": [ + "orphan receptor RevErb", + "N - CoR", + "thyroid hormone receptor", + "TR", + "retinoic acid receptor", + "RAR" + ] + }, + { + "id": "1971", + "type": "gene", + "text": "No homologs of other members of the Surfeit gene cluster were detected in close proximity to the D . melanogaster Surf - 3 / rpL7a gene .", + "entities": [ + "Surfeit gene cluster", + "Surf - 3", + "rpL7a" + ] + }, + { + "id": "1972", + "type": "gene", + "text": "The radial forearm flap is used most commonly , however the lateral arm flap may be the flap of choice in certain situations .", + "entities": [] + }, + { + "id": "1973", + "type": "gene", + "text": "Here , we describe the isolation of MdPin1 , a Pin1 homologue from the plant species apple ( Malus domestica ) and show that it has the same phosphorylation - specific substrate specificity and can be inhibited by juglone in vitro , as is the case for Pin1 .", + "entities": [ + "MdPin1", + "Pin1", + "Pin1" + ] + }, + { + "id": "1974", + "type": "gene", + "text": "In ICU patients , the LIS related to the postoperative rise in IL - 6 level only , even though the rise in plasma concentrations of cytokines interrelated .", + "entities": [ + "IL - 6" + ] + }, + { + "id": "1975", + "type": "gene", + "text": "As hGM - CSF receptor ( hGMR ) does not contain a consensus sequence for binding of PI 3 - kinase , hGMR must use a distinct mechanism for its association with and activation of PI 3 - kinase .", + "entities": [ + "hGM - CSF receptor", + "hGMR", + "PI 3 - kinase", + "hGMR", + "PI 3 - kinase" + ] + }, + { + "id": "1976", + "type": "gene", + "text": "Familial autoimmune hepatitis and C4 deficiency", + "entities": [ + "C4" + ] + }, + { + "id": "1977", + "type": "gene", + "text": "Administration of anticoagulants , i . e . , heparin , prostaglandin E1 and ticlopidine seems to be effective in alleviating symptoms and might prevent further deterioration .", + "entities": [] + }, + { + "id": "1978", + "type": "gene", + "text": "Furthermore , although the regional distribution of lean tissue mass in the trunk and legs remained fairly constant at different pubertal stages , the regional distribution of fat was altered significantly , becoming more central and less peripheral .", + "entities": [] + }, + { + "id": "1979", + "type": "gene", + "text": "Transcriptional activation by thyroid hormone ( T3 ) requires interactions between the T3 receptor ( TR ) and T3 response elements ( TREs ) composed of two copies of sequences related to AGGTCA .", + "entities": [ + "T3 receptor", + "TR" + ] + }, + { + "id": "1980", + "type": "gene", + "text": "Molecular cloning of human cDNA encoding a novel beta1 , 6 - N - acetylglucosaminyltransferase forming core 2 and core 4 .", + "entities": [ + "beta1 , 6 - N - acetylglucosaminyltransferase" + ] + }, + { + "id": "1981", + "type": "gene", + "text": "The calcium ratio ( mean ratio of the predicted to measured TBCa ) in men was 1 . 000 + / - 7 . 8 % and in women 0 . 996 + / - 7 . 1 % .", + "entities": [] + }, + { + "id": "1982", + "type": "gene", + "text": "The evidence presented here suggests that the p40 complex is a ribonucleoprotein complex containing L1Hs RNA ( s ) and that protein - protein interactions in which alpha - helix structures participate , for example coiled - coils , may occur in the complex .", + "entities": [ + "p40 complex", + "L1Hs RNA ( s )" + ] + }, + { + "id": "1983", + "type": "gene", + "text": "The distribution of the various repeats suggests its organization is similar to the beta - heterochromatic regions near the base of the major chromosome arms .", + "entities": [] + }, + { + "id": "1984", + "type": "gene", + "text": "Developmental follow - up at age 2 years was performed .", + "entities": [] + }, + { + "id": "1985", + "type": "gene", + "text": "FLP and Cre recombinase function in Xenopus embryos .", + "entities": [ + "FLP", + "Cre recombinase" + ] + }, + { + "id": "1986", + "type": "gene", + "text": "The deduced amino acid sequences of each of the W3A1 ETF subunits exhibit only approximately 30 % identity with the corresponding subunits of the ETF from human , rat , and Paracoccus denitrificans , which as a group are greater than 50 % identical .", + "entities": [ + "W3A1 ETF subunits", + "ETF" + ] + }, + { + "id": "1987", + "type": "gene", + "text": "Cutis aplasia .", + "entities": [] + }, + { + "id": "1988", + "type": "gene", + "text": "The deduced amino acid sequence was highly conserved across the wide range of eukaryotes ( vertebrates , invertebrates , fungi , plants and protozoa ) in which this gene has now been identified .", + "entities": [] + }, + { + "id": "1989", + "type": "gene", + "text": "The SEN1 gene corresponds to a 6 , 336 - bp open reading frame coding for a 2 , 112 - amino - acid protein ( molecular mass , 239 kDa ) .", + "entities": [ + "SEN1 gene" + ] + }, + { + "id": "1990", + "type": "gene", + "text": "Disturbance of regeneration in the above pathological condition results from the damage to tunica propria and loss of its function for the support of structural homeostasis .", + "entities": [] + }, + { + "id": "1991", + "type": "gene", + "text": "From day 10 , a significant increase in platelet count was observed in eight of the ten patients treated with heparin ( p < 0 . 05 ) , with return to the initial value after heparin cessation in six of the responders .", + "entities": [] + }, + { + "id": "1992", + "type": "gene", + "text": "Importance of determining the blood sulfhydryl groups in fractures of the long tubular bones complicated by infection", + "entities": [] + }, + { + "id": "1993", + "type": "gene", + "text": "The relationship of human umbilical arterial and venous plasma levels of corticosteroids to gestational age .", + "entities": [] + }, + { + "id": "1994", + "type": "gene", + "text": "A total number of 1628 cases were collected from 135 medical institutions .", + "entities": [] + }, + { + "id": "1995", + "type": "gene", + "text": "Ten patients with advanced , diffuse Hodgkin ' s and non - Hodgkin ' s lymphomas responding poorly to the most widely employed primary chemotherapy regimens were treated with a high - dose chemotherapy ( HDC ) followed by rescue with non - frozen autologous bone marrow infusion ( ABMT ) .", + "entities": [] + }, + { + "id": "1996", + "type": "gene", + "text": "When overexpressed in an appropriate cell line , TAN - 1C prevented kappa B - dependent transactivation in transient reporter gene assays in a fashion similar to the structurally related protein , Bcl - 3 .", + "entities": [ + "TAN - 1C", + "kappa B", + "Bcl - 3" + ] + }, + { + "id": "1997", + "type": "gene", + "text": "These results suggest that NZ - 107 may be a useful drug for the treatment of bronchial asthma by reducing late - phase airway responses and airway hyperreactivity .", + "entities": [] + }, + { + "id": "1998", + "type": "gene", + "text": "Temafloxacin 400 mg b . i . d . administered orally for 28 days represents a safe and effective treatment for chronic bacterial prostatitis .", + "entities": [] + }, + { + "id": "1999", + "type": "gene", + "text": "All 8 ( 100 % ) patients with fulminant hepatic failure who received grafts survived , including 3 who received ABO - incompatible grafts , though 2 of these subsequently required retransplantation .", + "entities": [] + }, + { + "id": "2000", + "type": "gene", + "text": "No local destruction by tumor or infection could be demonstrated apart from HIV infection .", + "entities": [] + }, + { + "id": "2001", + "type": "gene", + "text": "Hovenitin I and ( + ) - ampelopsin , both of which were principal ingredients of the active fractions from this natural medicine , were found to show an inhibitory activity on the ethanol - induced muscle relaxation in rats .", + "entities": [] + }, + { + "id": "2002", + "type": "gene", + "text": "These results indicate that inhibition of Jun kinase activation was sufficient to inhibit Ras transformation even in the presence of activated Erk - 2 .", + "entities": [ + "Jun kinase", + "Ras", + "Erk - 2" + ] + }, + { + "id": "2003", + "type": "gene", + "text": "The 10 kDa polypeptide was phosphorylated in vitro by incubating wheat etioplast membranes with [ gamma 32P ] ATP .", + "entities": [] + }, + { + "id": "2004", + "type": "gene", + "text": "Karger AG , Basel", + "entities": [] + }, + { + "id": "2005", + "type": "gene", + "text": "In contrast , H - NS negative regulation operated only in the absence of Fur .", + "entities": [ + "H - NS", + "Fur" + ] + }, + { + "id": "2006", + "type": "gene", + "text": "The intensity of the SSTEs is an order of magnitude larger than that of the MSEs and determines the signal contrast if both effects are selected simultaneously .", + "entities": [] + }, + { + "id": "2007", + "type": "gene", + "text": "Finally , we show that PhLP complexes , at least partially , with Gbetagamma in vivo .", + "entities": [ + "PhLP", + "Gbetagamma" + ] + }, + { + "id": "2008", + "type": "gene", + "text": "The Genescan program predicted an open reading frame of a novel , intron - less gene adjacent to the B236 spot that encodes a putative 493 - amino acid protein containing the SNAG repressor motif in the NH2 - terminal region and five C2H2 - type zinc finger motifs in the COOH - terminal half .", + "entities": [] + }, + { + "id": "2009", + "type": "gene", + "text": "These different observations exclude a heterozygosity of the A - - > G mutation at codon beta 77 , as well as a deletion comparable to that of Hbs Lepore or Kenya , or a beta - globin gene duplication , and point to a nontraditional inheritance of Hb Costa Rica .", + "entities": [ + "Hbs Lepore or Kenya", + "beta - globin gene", + "Hb Costa Rica" + ] + }, + { + "id": "2010", + "type": "gene", + "text": "In the first , homologous sequences were deleted from a mouse enhancer , resulting in a tissue - specific loss of activity when assayed in transgenic mice .", + "entities": [] + }, + { + "id": "2011", + "type": "gene", + "text": "Deletion of the RVH domain resulted in loss of Ca ( 2 + ) - dependent activation .", + "entities": [ + "RVH domain" + ] + }, + { + "id": "2012", + "type": "gene", + "text": "Concomitantly , p34CDC2 histone H1 kinase activity increases in the former , but not in the latter cell lines , hence suggesting a role for this protein in radiation - induced cell death .", + "entities": [ + "histone H1" + ] + }, + { + "id": "2013", + "type": "gene", + "text": "DAF is a 70 kD glycoprotein containing complement regulatory short consensus repeats ( SCRs ) ; its gene is located in the regulation of complement activation ( RCA ) gene cluster on chromosome 1 and is about 40 kb in size .", + "entities": [ + "DAF", + "regulation of complement activation", + "RCA" + ] + }, + { + "id": "2014", + "type": "gene", + "text": "In eukaryotic cells , premature termination of translation at nonsense codons has been implicated as the cause of a variety of posttranscriptional events , including rapid mRNA decay in the cytoplasm or the nucleus , altered splice site selection , and exon skipping .", + "entities": [] + }, + { + "id": "2015", + "type": "gene", + "text": "At necropsy 28 days post - inoculation , F344 rats had no gross lung lesions , even those given the maximum dose of 1 . 4 X 10 ( 9 ) colony - forming units of M . pulmonis .", + "entities": [] + }, + { + "id": "2016", + "type": "gene", + "text": "CONCLUSIONS AND CLINICAL RELEVANCE : Increased cortical thickness and geometric properties of left MCB - IV and - V of Greyhounds , together with altered turnover and orientation of osteons in the dorsal quadrants of left MCB , are site - specific adaptive responses associated with asymmetric cyclic loading as a result of racing on circular tracks .", + "entities": [] + }, + { + "id": "2017", + "type": "gene", + "text": "Are low P300 amplitudes a marker for schizophrenia .", + "entities": [] + }, + { + "id": "2018", + "type": "gene", + "text": "Northern blot analysis revealed the expression of LIMK - 1 mRNA predominantly in the brain and the expression of LIMK - 2 mRNA in various tissues in the rat .", + "entities": [ + "LIMK - 1 mRNA", + "LIMK - 2 mRNA" + ] + }, + { + "id": "2019", + "type": "gene", + "text": "However , the N63S mutation in the wild - type VP5 background increased the interaction , as judged by the beta - galactosidase activity , by a factor of 9 relative to when the PR7 mutation was present .", + "entities": [ + "wild - type VP5", + "beta - galactosidase" + ] + }, + { + "id": "2020", + "type": "gene", + "text": "A constitutive mutant form with a single substitution ( V88A ) in the amino - terminal ( response regulator ) region was used .", + "entities": [] + }, + { + "id": "2021", + "type": "gene", + "text": "Clinical trials with 1 , 3 - bis ( 2 - chloroethyl ) - 1 - nitrosourea , NSC - 409962 .", + "entities": [] + }, + { + "id": "2022", + "type": "gene", + "text": "Because chromosome X is frequently involved in structural alterations in neoplastic Syrian hamster cells transformed by chemical carcinogens and oncogenic viruses , the localization of the cph locus on this chromosome supports the notion that the cph oncogene plays a role in the malignant conversion of chemically transformed hamster fibroblasts .", + "entities": [ + "cph locus", + "cph oncogene" + ] + }, + { + "id": "2023", + "type": "gene", + "text": "In human brain , contactin was first identified by amino terminal and peptide sequencing of the lentil - lectin - binding glycoprotein Gp135 .", + "entities": [ + "contactin", + "lentil - lectin - binding glycoprotein Gp135" + ] + }, + { + "id": "2024", + "type": "gene", + "text": "The lymph nodes from two of the patients with rheumatoid arthritis contained numerous sarcoid like granulomata , further indicating a possible association between sarcoidosis and rheumatoid arthritis .", + "entities": [] + }, + { + "id": "2025", + "type": "gene", + "text": "Pharmacoeconomic assessment of HMG - CoA reductase inhibitor therapy : an analysis based on the CURVES study .", + "entities": [ + "HMG - CoA reductase" + ] + }, + { + "id": "2026", + "type": "gene", + "text": "A major mechanism by which estrogens prevent osteoporosis seems to be repression of transcription of NF - kappa B target genes , such as the osteoclast - activating cytokines interleukin - 6 and interleukin - 1 .", + "entities": [ + "NF - kappa B target genes", + "interleukin - 6", + "interleukin - 1" + ] + }, + { + "id": "2027", + "type": "gene", + "text": "It can also be used to examine various laryngeal parameters obtained from videotaped endoscopic and stroboscopic examinations .", + "entities": [] + }, + { + "id": "2028", + "type": "gene", + "text": "Arsenic contents in native copper", + "entities": [] + }, + { + "id": "2029", + "type": "gene", + "text": "Kidney length did not significantly differ between right and left , however , kidney width , cortical thickness and size did ( p < 0 . 05 ) .", + "entities": [] + }, + { + "id": "2030", + "type": "gene", + "text": "We also report that AHR interacts with COUP - TF in transfected CV - 1 cells .", + "entities": [ + "AHR", + "COUP - TF" + ] + }, + { + "id": "2031", + "type": "gene", + "text": "In vitro DNase I footprinting of the 200 - bp proximal region of the promoter with a murine Hepa 1 - 6 cell nuclear extract revealed a clear footprint of a region corresponding to - 80 to - 28 bp of the murine fVII gene , suggesting that liver factors interact with this region of the DNA .", + "entities": [ + "DNase I", + "murine fVII gene" + ] + }, + { + "id": "2032", + "type": "gene", + "text": "We couldn ' t detect any effect of n - 3 FA supplementation on total cholesterol , HDL cholesterol , LDL cholesterol , apo A1 , Lp ( a ) , HbA1C , glucose , fibrinogen , factor VIII , antithrombin III , plasminogen activator inhibitor , tissue plasminogen activator and von Willebrand factor concentration , on bleeding time or on systolic or diastolic blood pressure .", + "entities": [ + "HDL cholesterol", + "LDL cholesterol", + "apo A1", + "Lp ( a )", + "HbA1C", + "fibrinogen", + "factor VIII", + "antithrombin III", + "plasminogen activator inhibitor", + "tissue plasminogen activator", + "von Willebrand factor" + ] + }, + { + "id": "2033", + "type": "gene", + "text": "A v - erbB - related protooncogene , c - erbB - 2 , is distinct from the c - erbB - 1 / epidermal growth factor - receptor gene and is amplified in a human salivary gland adenocarcinoma .", + "entities": [ + "v - erbB - related protooncogene", + "c - erbB - 2", + "c - erbB - 1", + "epidermal growth factor - receptor" + ] + }, + { + "id": "2034", + "type": "gene", + "text": "Hypoglycemic and antidiabetic properties", + "entities": [] + }, + { + "id": "2035", + "type": "gene", + "text": "A total of 576 1 - day - old Ross broiler chicks were housed in six treatment groups [ six replicates of 16 each ; control , CLI ( 15 g kg ( - 1 ) diet ) , 50 parts per billion ( ppb ) AF , 50 ppb AF plus CLI , 100 ppb AF , 100 ppb AF plus CLI ] for 42 days .", + "entities": [ + "AF", + "AF", + "AF", + "AF" + ] + }, + { + "id": "2036", + "type": "gene", + "text": "Here , we have used specific antibody to identify and characterize the SSN6 protein .", + "entities": [ + "SSN6 protein" + ] + }, + { + "id": "2037", + "type": "gene", + "text": "86 : 3199 - 3203 ) or G1 to S phase ( Reilly , C .", + "entities": [] + }, + { + "id": "2038", + "type": "gene", + "text": "Molecules of NH3 are capable of emitting stimulated radiation ( MASER ) .", + "entities": [] + }, + { + "id": "2039", + "type": "gene", + "text": "Studies of lipogenesis by labelled precursors in the pregnant rat .", + "entities": [] + }, + { + "id": "2040", + "type": "gene", + "text": "To address these questions , a recombinant FRAP / mTOR protein and a FRAP / mTOR immunoprecipitate were utilized in in vitro kinase assays to phosphorylate 4E - BP1 .", + "entities": [ + "FRAP", + "mTOR", + "FRAP", + "mTOR", + "4E - BP1" + ] + }, + { + "id": "2041", + "type": "gene", + "text": "Amino acid sequence of one human liver clone ( HL - 14 ) was identical to the rabbit skeletal muscle phosphatase 2A cDNA ( with 97 % nucleotide identity ) .", + "entities": [ + "rabbit skeletal muscle phosphatase 2A cDNA" + ] + }, + { + "id": "2042", + "type": "gene", + "text": "The 5 ' region shows strong sequence similarity to Escherichia coli consensus promoters and ribosome - binding sequences and allows high levels of expression in E . coli .", + "entities": [] + }, + { + "id": "2043", + "type": "gene", + "text": "Synthetic ligands have been identified that reset and amplify the cycle of pulsatile GH secretion by interacting with the orphan GH - secretagogue receptor ( GHS - R ) .", + "entities": [ + "GH", + "orphan GH - secretagogue receptor", + "GHS - R" + ] + }, + { + "id": "2044", + "type": "gene", + "text": "This L - myc sequence is amplified 10 - 20 - fold in four SCLC cell line DNAs and in one SCLC tumour specimen taken directly from a patient .", + "entities": [ + "L - myc sequence" + ] + }, + { + "id": "2045", + "type": "gene", + "text": "Laryngographic changes following endotracheal intubation in adults .", + "entities": [] + }, + { + "id": "2046", + "type": "gene", + "text": "METHODS : Forty - nine cases with intrahepatic multiple nodules of HCC , by gross examination , among 184 consecutive resected HCCs were examined clinicopathologically .", + "entities": [] + }, + { + "id": "2047", + "type": "gene", + "text": "However , the truncated deer receptor lacks the most C - terminal tyrosine residue in the intracellular domain which is believed to be essential for activation of the beta - casein promoter .", + "entities": [ + "deer receptor", + "beta - casein promoter" + ] + }, + { + "id": "2048", + "type": "gene", + "text": "Although further studies are required to determine the precise role of PEBP2 in the GM - CSF promoter activity , the present findings suggested the importance of the relative ratio of different PEBP2 isoforms in regulating the levels of the promoter activity .", + "entities": [ + "PEBP2", + "GM - CSF promoter", + "PEBP2 isoforms" + ] + }, + { + "id": "2049", + "type": "gene", + "text": "NKX2 . 1 is a member of the NK2 family of homeodomain - containing transcription factors whose targeted disruption in mouse results in the absence of thyroid tissue and a severely abnormal lung phenotype .", + "entities": [ + "NKX2 . 1", + "NK2 family", + "homeodomain - containing transcription factors" + ] + }, + { + "id": "2050", + "type": "gene", + "text": "The first one is a TPA - responsive element that controls the base - line ST3 promoter activity but is not required for its activation .", + "entities": [ + "ST3 promoter" + ] + }, + { + "id": "2051", + "type": "gene", + "text": "The central globular domain is highly similar to those regions from other H1 molecules , and the carboxyl - terminal domain contains a repeating hexapeptide motif , variants of which are conserved among H1 molecules .", + "entities": [ + "H1 molecules", + "H1 molecules" + ] + }, + { + "id": "2052", + "type": "gene", + "text": "Time shifts increase growth hormone release .", + "entities": [ + "growth hormone" + ] + }, + { + "id": "2053", + "type": "gene", + "text": "The nucleotide sequence of the gene predicts a polypeptide of 215 amino acids ( 25 . 2 kDa ) with two putative membrane - spanning domains .", + "entities": [] + }, + { + "id": "2054", + "type": "gene", + "text": "Using an RNase H protection assay and specific blocking oligonucleotides , we find that recognition of the 5 ' splice - site ( 5 ' ss ) and branchpoint sequence ( BPS ) elements by U11 and U12 snRNPs , respectively , displays strong cooperativity , requiring both sites in the pre - mRNA substrate for efficient complex formation .", + "entities": [ + "RNase H", + "U11", + "U12 snRNPs" + ] + }, + { + "id": "2055", + "type": "gene", + "text": "0 . 61 + / - 0 . 04 ) .", + "entities": [] + }, + { + "id": "2056", + "type": "gene", + "text": "Expression of a dominant - negative mutant of JNK1 also suppressed glucose deprivation - induced JNK1 activation as well as HSP70 gene expression .", + "entities": [ + "JNK1", + "JNK1", + "HSP70 gene" + ] + }, + { + "id": "2057", + "type": "gene", + "text": "The mHIF - 1 alpha structural gene is composed of 15 exons .", + "entities": [ + "mHIF - 1 alpha structural gene" + ] + }, + { + "id": "2058", + "type": "gene", + "text": "The avian cellular homolog of the oncogene jun .", + "entities": [ + "oncogene jun" + ] + }, + { + "id": "2059", + "type": "gene", + "text": "It was found that the disappearance of BOD5 and NH3 - N could be approximated using first - order kinetics , but the kinetics of TP removal were unclear .", + "entities": [] + }, + { + "id": "2060", + "type": "gene", + "text": "It was found that the disappearance of BOD5 and NH3 - N could be approximated using first - order kinetics , but the kinetics of TP removal were unclear .", + "entities": [] + }, + { + "id": "2061", + "type": "gene", + "text": "Mitogen - induced lymphocyte proliferation was diminished .", + "entities": [] + }, + { + "id": "2062", + "type": "gene", + "text": "Experiments were performed in which brain - stem auditory - evoked responses ( BAERs ) were elicited by two types of pseudorandom pulse trains : maximum length sequences ( MLS ) and Legendre sequences ( LGS ) .", + "entities": [] + }, + { + "id": "2063", + "type": "gene", + "text": "A heterologous promoter construct containing three repeats of a consensus Sp1 site , cloned upstream of a single copy of the ZII ( CREB / AP1 ) element from the BZLF1 promoter linked to the beta - globin TATA box , exhibited phorbol ester inducibility .", + "entities": [ + "Sp1 site", + "ZII", + "CREB / AP1", + "BZLF1 promoter", + "beta - globin" + ] + }, + { + "id": "2064", + "type": "gene", + "text": "We conclude from these studies that CKII may act as a positive regulator of myogenesis by preventing E protein homodimers from binding to muscle gene regulatory elements .", + "entities": [ + "CKII", + "E protein homodimers" + ] + }, + { + "id": "2065", + "type": "gene", + "text": "Furthermore , direct association with D3 phosphatidylinositides seems to be essential for activation of PKB / Akt .", + "entities": [ + "PKB", + "Akt" + ] + }, + { + "id": "2066", + "type": "gene", + "text": "These results demonstrate that EKLF provides a crucial transactivation function for globin expression and further reinforce the idea that EKLF is an important regulator of CACCC element - directed transcription in erythroid cells .", + "entities": [ + "EKLF", + "globin", + "EKLF" + ] + }, + { + "id": "2067", + "type": "gene", + "text": "Effects of cisapride on upper - gastrointestinal motility and digestive hormones", + "entities": [] + }, + { + "id": "2068", + "type": "gene", + "text": "It has repeatedly been shown that HCMV IE1 / IE2 can independently transactivate HIV - 1 LTR .", + "entities": [ + "IE1", + "IE2", + "HIV - 1 LTR" + ] + }, + { + "id": "2069", + "type": "gene", + "text": "Similarly , maternal serum somatomedin A was significantly reduced in rats nursing large litters .", + "entities": [ + "maternal serum somatomedin A" + ] + }, + { + "id": "2070", + "type": "gene", + "text": "It is mainly transcribed in neural structures and in developing organs characterized by epithelial - mesenchymal interactions .", + "entities": [] + }, + { + "id": "2071", + "type": "gene", + "text": "The coordinated expression of CD4 and CD8 during T - cell development is tightly coupled with the maturation state of the T cell .", + "entities": [ + "CD4", + "CD8" + ] + }, + { + "id": "2072", + "type": "gene", + "text": "The effect of sodium 18 beta - glycyrrhetate ( SGA ) on experimental arrhythmia was investigated .", + "entities": [] + }, + { + "id": "2073", + "type": "gene", + "text": "Am .", + "entities": [] + }, + { + "id": "2074", + "type": "gene", + "text": "This interaction is mediated by the SH2 domain of Crk and can be inhibited with a phosphopeptide containing the Crk - SH2 binding motif .", + "entities": [ + "SH2 domain", + "Crk", + "Crk", + "SH2" + ] + }, + { + "id": "2075", + "type": "gene", + "text": "However , five new mutation sites ( S61 , SL1 , S29 , SL11 , SL196 and SL126 ) are unique to the nrdB intron and disrupt self - splicing .", + "entities": [ + "S61", + "SL1", + "S29", + "SL11", + "SL196", + "SL126", + "nrdB" + ] + }, + { + "id": "2076", + "type": "gene", + "text": "In conclusion , tube size estimated by Cole ' s formula tends to be smaller than practically appropriate tube size for pediatric cardiac anesthesia , and therefore we suggest new formula to estimate the tube size .", + "entities": [] + }, + { + "id": "2077", + "type": "gene", + "text": "To test whether or not SOCS - 3 also binds to the IGFIR , we cloned human SOCS - 3 by reverse transcription - polymerase chain reaction from human skeletal muscle mRNA .", + "entities": [ + "SOCS - 3", + "IGFIR", + "human SOCS - 3" + ] + }, + { + "id": "2078", + "type": "gene", + "text": "Furthermore , using transgenic mouse technology we localized independent cis - regulatory elements controlling the tissue - specific expression of Pax6 .", + "entities": [ + "Pax6" + ] + }, + { + "id": "2079", + "type": "gene", + "text": "Higher CYP3A23 basal activity appears to be due to an E - box in 3A23SiteA that interacts with USF1 , a ubiquitous bHLH / leucine zipper transcription factor .", + "entities": [ + "CYP3A23", + "3A23SiteA", + "USF1", + "bHLH / leucine zipper transcription factor" + ] + }, + { + "id": "2080", + "type": "gene", + "text": "Fragments and analogs of the hormone ACTH were previously shown to have beneficial effect on the outcome of head injury , while elevated levels of corticosterone ( CS ) exacerbate it .", + "entities": [ + "ACTH" + ] + }, + { + "id": "2081", + "type": "gene", + "text": "Salazopyrine desensitization", + "entities": [] + }, + { + "id": "2082", + "type": "gene", + "text": "Shoulder forearm support for the subluxed shoulder .", + "entities": [] + }, + { + "id": "2083", + "type": "gene", + "text": "Unitary - group approach to spin - dependent operators .", + "entities": [] + }, + { + "id": "2084", + "type": "gene", + "text": "This analysis revealed that SAP 145 , together with four other SF3a / SF3b subunits , UV cross - links to pre - mRNA in a 20 - nucleotide region upstream of the BPS .", + "entities": [ + "SAP 145", + "SF3a", + "SF3b" + ] + }, + { + "id": "2085", + "type": "gene", + "text": "Furthermore , DNA - bound LAZ3 / BCL6 recruits SMRT in vivo , and both overexpressed proteins completely colocalize in nuclear dots .", + "entities": [ + "LAZ3", + "BCL6", + "SMRT" + ] + }, + { + "id": "2086", + "type": "gene", + "text": "Sequences downstream of the two human CA genes , possibly containing homologous enhancer elements , have not yet been reported .", + "entities": [ + "human CA genes" + ] + }, + { + "id": "2087", + "type": "gene", + "text": "CONCLUSION : The training of novices using MIST - VR yields quantifiable changes in skill that are transferable to a simple real task and are similar to the results achieved with conventional training .", + "entities": [] + }, + { + "id": "2088", + "type": "gene", + "text": "Implications in biomonitoring of the observed accumulation patterns , especially in the different tissues of Posidonia oceanica , are discussed .", + "entities": [] + }, + { + "id": "2089", + "type": "gene", + "text": "This is necessary if psychiatric diagnoses are ultimately going to be refined and validated against biological criteria .", + "entities": [] + }, + { + "id": "2090", + "type": "gene", + "text": "Potential indicators were assessed for the two classifications of protein - energy malnutrition in the guidelines for integrated management of childhood illness : severe malnutrition , which requires immediate referral to hospital , and very low weight , which calls for feeding assessment , nutritional counselling and follow - up .", + "entities": [] + }, + { + "id": "2091", + "type": "gene", + "text": "An AP - 1 binding sequence is essential for regulation of the human alpha2 ( I ) collagen ( COL1A2 ) promoter activity by transforming growth factor - beta .", + "entities": [ + "AP - 1 binding sequence", + "human alpha2 ( I ) collagen", + "COL1A2", + "transforming growth factor - beta" + ] + }, + { + "id": "2092", + "type": "gene", + "text": "Altogether 46 phase III activities were recorded .", + "entities": [] + }, + { + "id": "2093", + "type": "gene", + "text": "Initial results indicate that this 23S pre - rRNA is the same as the species detected on depletion of the small nucleolar RNA - associated proteins NOP1 and GAR1 and in an snr10 mutant strain .", + "entities": [ + "23S pre - rRNA", + "NOP1", + "GAR1", + "snr10 mutant" + ] + }, + { + "id": "2094", + "type": "gene", + "text": "Cys - 757 within the ( Fe4S4 ) - siroheme - binding domain was essential for native enzyme activity .", + "entities": [] + }, + { + "id": "2095", + "type": "gene", + "text": "2 new Algerian cases", + "entities": [] + }, + { + "id": "2096", + "type": "gene", + "text": "In a previous interim report we noted more prompt resolution of dermatomal signs and symptoms with acyclovir treatment .", + "entities": [] + }, + { + "id": "2097", + "type": "gene", + "text": "Prrp can also associate with the EVH1 domain of Mena , another microfilament - associated protein .", + "entities": [ + "Prrp", + "EVH1 domain", + "Mena" + ] + }, + { + "id": "2098", + "type": "gene", + "text": "DNase I footprinting and electrophoretic mobility shift assays indicate that PBP binds to the half - site of each palindrome with the core recognition sequence TGGGAG .", + "entities": [ + "DNase I", + "PBP" + ] + }, + { + "id": "2099", + "type": "gene", + "text": "A portion of p193 is nuclear and localizes to the mitotic spindle .", + "entities": [ + "p193" + ] + }, + { + "id": "2100", + "type": "gene", + "text": "Krox - 24 is therefore a sequence - specific transcriptional activator .", + "entities": [ + "Krox - 24" + ] + }, + { + "id": "2101", + "type": "gene", + "text": "Leads from the MMWR .", + "entities": [] + }, + { + "id": "2102", + "type": "gene", + "text": "On the comparison of correlated proportions for clustered data .", + "entities": [] + }, + { + "id": "2103", + "type": "gene", + "text": "Mutations in the RP2 locus at Xp11 . 3 were found in a further 10 - 20 % of XLRP patients , as predicted from linkage studies .", + "entities": [ + "RP2 locus at Xp11 . 3" + ] + }, + { + "id": "2104", + "type": "gene", + "text": "The effects of anabolic implants on rate , composition and energetic efficiency of growth were determined in steers fed diets varying in forage and grain content .", + "entities": [] + }, + { + "id": "2105", + "type": "gene", + "text": "One of its lysine residues is modified by spermidine to form hypusine , a posttranslational modification unique to eIF - 5A .", + "entities": [ + "eIF - 5A" + ] + }, + { + "id": "2106", + "type": "gene", + "text": "After overtraining on the original discrimination , the controls showed the normal difficulty in learning the first reversal .", + "entities": [] + }, + { + "id": "2107", + "type": "gene", + "text": "Cerebral flow and resistance showed minor reductions with HD .", + "entities": [] + }, + { + "id": "2108", + "type": "gene", + "text": "The ATR - X syndrome results from mutations of the XH2 gene , located on the X chromosome ( Xq13 . 3 ) and coding for a transacting factor which regulates gene expression .", + "entities": [ + "XH2 gene" + ] + }, + { + "id": "2109", + "type": "gene", + "text": "Chemical stability tests and site - specific mutagenesis identified amino acids H219 and D63 of RegS and RegR , respectively , as the phosphorylated residues .", + "entities": [ + "RegS", + "RegR" + ] + }, + { + "id": "2110", + "type": "gene", + "text": "Thyroid disease and pregnancy .", + "entities": [] + }, + { + "id": "2111", + "type": "gene", + "text": "Fourth , sometime between 4 and 24 hours of recovery is necessary to reverse the effect of chronic hypoxia on cerebral blood flow .", + "entities": [] + }, + { + "id": "2112", + "type": "gene", + "text": "The new algorithm , called RBI - MAP , is based on the rescaled block iterative EM ( RBI - EM ) algorithm .", + "entities": [] + }, + { + "id": "2113", + "type": "gene", + "text": "Fractionation of crude nuclear extracts by heparin - agarose chromatography indicates that PCAT - 1 is more prevalent in extracts prepared from salt - stressed leaf tissue .", + "entities": [ + "PCAT - 1" + ] + }, + { + "id": "2114", + "type": "gene", + "text": "Neurofibromatosis of the breast in a patient with Morbus von Recklinghausen", + "entities": [] + }, + { + "id": "2115", + "type": "gene", + "text": "Whereas MARTA1 is clearly detectable in crude lysates , cytosolic and ribosomal salt - wash fractions , and in nuclear extracts , MARTA2 is preferentially found in the ribosomal salt - wash preparation .", + "entities": [ + "MARTA1", + "MARTA2" + ] + }, + { + "id": "2116", + "type": "gene", + "text": "We isolated a ribosomal protein L18 by interaction with PKR .", + "entities": [ + "ribosomal protein L18", + "PKR" + ] + }, + { + "id": "2117", + "type": "gene", + "text": "Wild type HA - p190 induced a phenotype of rounded cells with long , beaded extensions similar to that seen when Rho function is disrupted by ADP - ribosylation .", + "entities": [ + "HA", + "p190", + "Rho" + ] + }, + { + "id": "2118", + "type": "gene", + "text": "Lens aldose reductase in diabetic and galactosemic cataracts .", + "entities": [ + "Lens aldose reductase" + ] + }, + { + "id": "2119", + "type": "gene", + "text": "The HBP gene is composed of eight exons covering 19 . 5 kb on the short arm of chromosome 4 .", + "entities": [ + "HBP gene" + ] + }, + { + "id": "2120", + "type": "gene", + "text": "This distinction was based upon whether the diagnosis provided a straightforward range of prognoses or an ambiguous clinical implication .", + "entities": [] + }, + { + "id": "2121", + "type": "gene", + "text": "Demonstration of fine structure of the guinea pig organ of Corti after electron microscopic silver staining", + "entities": [] + }, + { + "id": "2122", + "type": "gene", + "text": "Serum relaxin levels in prostaglandin E2 induced abortions .", + "entities": [ + "Serum relaxin" + ] + }, + { + "id": "2123", + "type": "gene", + "text": "Penicillin - G degradation products inhibit in vitro granulopoiesis .", + "entities": [] + }, + { + "id": "2124", + "type": "gene", + "text": "A striking feature of the recombinant H19 allele is the occurrence of a parental imprint set on the neo replacement cassette .", + "entities": [ + "recombinant H19 allele", + "neo replacement cassette" + ] + }, + { + "id": "2125", + "type": "gene", + "text": "We propose that plasmids of the pLS1 family ( pE194 , pADB201 , and pLB4 ) share functional and structural characteristics for the regulation of their copy numbers .", + "entities": [] + }, + { + "id": "2126", + "type": "gene", + "text": "Here we show that a novel isoform of Rapl GTPase - activating protein , called rap1GAPII , binds specifically to the alpha - subunits of the G ( i ) family of heterotrimeric G - proteins .", + "entities": [ + "Rapl GTPase - activating protein", + "rap1GAPII", + "G ( i ) family", + "heterotrimeric G - proteins" + ] + }, + { + "id": "2127", + "type": "gene", + "text": "The present data also demonstrate that ectopic expression of blr1 increased JNK / SAPK activity , but JNK / SAPK activation was not needed for accelerated RA - induced differentiation and growth arrest .", + "entities": [ + "blr1", + "JNK", + "SAPK", + "JNK", + "SAPK" + ] + }, + { + "id": "2128", + "type": "gene", + "text": "Furthermore , we showed that ERSF including NF - Y and ATF6alpha and / or beta and capable of binding to ERSE is indeed formed when the cellular UPR is activated .", + "entities": [ + "ERSF", + "NF - Y", + "ATF6alpha and / or beta" + ] + }, + { + "id": "2129", + "type": "gene", + "text": "The complete circular TTV genome contained a novel sequence of 113 nt ( nt 3740 to 3852 [ = 0 ] ) in between the known 3 ' - and 5 ' - end arms , forming a 117 - nt GC - rich stretch ( GC content , 90 . 6 % at nt 3736 to 3852 ) .", + "entities": [] + }, + { + "id": "2130", + "type": "gene", + "text": "BACKGROUND : The MAZE - III is the surgical treatment of choice for medically refractory atrial fibrillation .", + "entities": [] + }, + { + "id": "2131", + "type": "gene", + "text": "Tolterodine users were 7 . 5 times more likely to have received another spasmolytic drug ( RR 7 . 5 , 95 % CI 4 . 8 to 11 . 9 ) .", + "entities": [] + }, + { + "id": "2132", + "type": "gene", + "text": "Haplotype mapping and sequence analysis of the mouse Nramp gene predict susceptibility to infection with intracellular parasites .", + "entities": [ + "Nramp gene" + ] + }, + { + "id": "2133", + "type": "gene", + "text": "Combination of 3 multiple primary malignant and benign tumors of the breasts and uterus", + "entities": [] + }, + { + "id": "2134", + "type": "gene", + "text": "These data indicate that the largest subunit of RNA polymerase II and TFIIB are important determinants of transcription start site selection in S . cerevisiae and suggest that this function might be conferred by interaction between these two proteins .", + "entities": [ + "RNA polymerase II", + "TFIIB" + ] + }, + { + "id": "2135", + "type": "gene", + "text": "Perturbation of dNTP pools also affected the frameshift fidelity of the replicative yeast DNA polymerase alpha .", + "entities": [ + "yeast DNA polymerase alpha" + ] + }, + { + "id": "2136", + "type": "gene", + "text": "Sequence determination of isolated peptides suggested that Asn120 is glycosylated , Asn65 and Asn109 glycosylated in some molecules but not in others , and Asn72 not glycosylated .", + "entities": [] + }, + { + "id": "2137", + "type": "gene", + "text": "In contrast , the CRE of the human c - fos promoter located at - 60 was weakly induced by cAMP and E1a in both HeLa and PC12 cells .", + "entities": [ + "human c - fos promoter", + "E1a" + ] + }, + { + "id": "2138", + "type": "gene", + "text": "The calculated values of lambda tb at 37 degrees C and 50 per cent haematocrit were 0 . 650 for the pulp , 0 . 674 for the tongue , 0 . 828 for the submandibular gland and 0 . 881 for the gingiva of the dog . lambda cp increased and lambda tp decreased as the temperature was reduced from 37 to 4 degrees C .", + "entities": [] + }, + { + "id": "2139", + "type": "gene", + "text": "Mutations in the alpha and sigma - 70 subunits of RNA polymerase affect expression of the mer operon .", + "entities": [ + "alpha and sigma - 70 subunits of RNA polymerase", + "mer operon" + ] + }, + { + "id": "2140", + "type": "gene", + "text": "The Drosophila insulin receptor homolog : a gene essential for embryonic development encodes two receptor isoforms with different signaling potential .", + "entities": [ + "Drosophila insulin receptor homolog" + ] + }, + { + "id": "2141", + "type": "gene", + "text": "Hypotension was produced by head up tilt .", + "entities": [] + }, + { + "id": "2142", + "type": "gene", + "text": "Sequence analysis of these regions showed a CAAT box upstream of exon 1a and high G - C content regions within both P1 and P2 .", + "entities": [] + }, + { + "id": "2143", + "type": "gene", + "text": "Regulation of pituitary vasopressin V1b receptors plays a critical role in regulating pituitary adrenocorticotropic hormone ( ACTH ) secretion during adaptation to stress .", + "entities": [ + "vasopressin V1b receptors", + "pituitary adrenocorticotropic hormone", + "ACTH" + ] + }, + { + "id": "2144", + "type": "gene", + "text": "The DNA sequence conferring AP - 1 activity was located in the proximal promoter region .", + "entities": [ + "AP - 1" + ] + }, + { + "id": "2145", + "type": "gene", + "text": "Although not consistently identified in all samples , secondary Academic , Personal Responsibility , and Community / Vocational dimensions were also identified .", + "entities": [] + }, + { + "id": "2146", + "type": "gene", + "text": "Treatment for this condition often involves use of a wax softening or dispersing agent ( cerumenolytic ) before syringing .", + "entities": [] + }, + { + "id": "2147", + "type": "gene", + "text": "The frequency of PPNG strains increased from 1 . 7 % in 1981 to 6 . 7 % in 1985 .", + "entities": [] + }, + { + "id": "2148", + "type": "gene", + "text": "In all cases the antigenemia was transient and cleared by 28th day post - vaccination .", + "entities": [] + }, + { + "id": "2149", + "type": "gene", + "text": "Second , nitrate induction of aeg - 46 . 5 operon expression is substantially enhanced in narL null strains ( M . H .", + "entities": [ + "aeg - 46 . 5 operon", + "narL" + ] + }, + { + "id": "2150", + "type": "gene", + "text": "Evidence for two distinctive clinical , epidemiological , and immunological types of infection .", + "entities": [] + }, + { + "id": "2151", + "type": "gene", + "text": "The large subfamily of receptor tyrosine kinases ( RTKs ) for which EPH is the prototype have likely roles in intercellular communication during normal mammalian development , but the biochemical signalling pathways utilised by this family are poorly characterised .", + "entities": [ + "receptor tyrosine kinases", + "RTKs", + "EPH" + ] + }, + { + "id": "2152", + "type": "gene", + "text": "Visual acuity may be decreased by transient changes in refractive error caused by sulfonamides , the antifungal agent metronidazole , thiazide diuretics , and carbonic anhydrase inhibitors .", + "entities": [ + "carbonic anhydrase" + ] + }, + { + "id": "2153", + "type": "gene", + "text": "Urine samples collected after the administration of these supplements can test positive .", + "entities": [] + }, + { + "id": "2154", + "type": "gene", + "text": "We report here that a 25 - bp promoter element previously shown to be important for the G1 - S activation of the human thymidine kinase ( htk ) promoter in growth - stimulated cells is a cellular target of cyclin A and the p33cdk2 complexes .", + "entities": [ + "human thymidine kinase", + "htk", + "cyclin A", + "p33cdk2 complexes" + ] + }, + { + "id": "2155", + "type": "gene", + "text": "By comparison , in nontumorigenic Ad5 cells , class I expression is high due to negligible binding of COUP - TF and strong binding of NF - kappaB .", + "entities": [ + "COUP - TF", + "NF - kappaB" + ] + }, + { + "id": "2156", + "type": "gene", + "text": "A randomized clinical trial in sixty - two adult patients suffering from typhoid fever , proved by blood and marrow culture , showed that amoxycillin in a dosage schedule of 1 g 8 - hourly orally for fourteen days was better than chloramphenicol with regard to clinical and temperature response and in respect of carriers and relapse rates .", + "entities": [] + }, + { + "id": "2157", + "type": "gene", + "text": "Human adenovirus type 41 contains two fibers .", + "entities": [] + }, + { + "id": "2158", + "type": "gene", + "text": "The patterns of early mRNA and protein expression in these seven mutants were examined , and it was found that mutation of the T ' ( 135 ) acceptor site resulted in the utilization of cryptic splice sites and the generation of new T ' species .", + "entities": [ + "T ' ( 135 )", + "T '" + ] + }, + { + "id": "2159", + "type": "gene", + "text": "The deduced amino acid sequence of the mouse HO - 1 gene is identical to that of p32 , initially identified as a stress - induced protein in mouse BALBc / 3T3 cells .", + "entities": [ + "mouse HO - 1 gene", + "p32" + ] + }, + { + "id": "2160", + "type": "gene", + "text": "Chem .", + "entities": [] + }, + { + "id": "2161", + "type": "gene", + "text": "The best regression model for predicting changes in the WCXR included time to first positive culture and antibody titer for Pa elastase .", + "entities": [ + "Pa elastase" + ] + }, + { + "id": "2162", + "type": "gene", + "text": "The PDH complex - encoding genes were identified by hybridization experiments and sequence analysis in two separate gene regions in the genome of Z . mobilis .", + "entities": [ + "PDH complex - encoding genes" + ] + }, + { + "id": "2163", + "type": "gene", + "text": "Of the cases with PLD , 50 % had associated renal cysts and 10 % of the cases with APCD had associated liver cysts .", + "entities": [] + }, + { + "id": "2164", + "type": "gene", + "text": "Nucleotide sequence of DNA controlling expression of genes for maltosaccharide utilization in Streptococcus pneumoniae .", + "entities": [] + }, + { + "id": "2165", + "type": "gene", + "text": "Interestingly , EGF , but not insulin , stimulated tyrosine phosphorylation of c - cbl and its association with Crk - II .", + "entities": [ + "EGF", + "insulin", + "c - cbl", + "Crk - II" + ] + }, + { + "id": "2166", + "type": "gene", + "text": "No specific subgroup of clients benefited more from URD , although a prospective study employing random assignment might be more successful in identifying such a group .", + "entities": [] + }, + { + "id": "2167", + "type": "gene", + "text": "Functional domains of c - myc promoter binding protein 1 involved in transcriptional repression and cell growth regulation .", + "entities": [ + "c - myc promoter binding protein 1" + ] + }, + { + "id": "2168", + "type": "gene", + "text": "The PAC clone with an insert size of 120kb was isolated and mapped by restriction analysis .", + "entities": [] + }, + { + "id": "2169", + "type": "gene", + "text": "We have partially sequenced the RAP74 protein from purified HeLa cells , cloned its complementary DNA and shown that its translation product can interact with RAP30 in vitro as well as in vivo .", + "entities": [ + "RAP74 protein", + "RAP30" + ] + }, + { + "id": "2170", + "type": "gene", + "text": "Many of the important genes associated with G1 regulation have been shown to play a key role in proliferation , differentiation and oncogenic transformation and programmed cell death ( apoptosis ) .", + "entities": [] + }, + { + "id": "2171", + "type": "gene", + "text": "Exploratory - motor task to evaluate right frontal lobe damage .", + "entities": [] + }, + { + "id": "2172", + "type": "gene", + "text": "Haploid cells of mating type A of the basidiomycetous yeast Rhodosporidium toruloides secrete a mating pheromone , rhodotorucine A , which is an undecapeptide containing S - farnesyl cysteine at its carboxy terminus .", + "entities": [ + "rhodotorucine A" + ] + }, + { + "id": "2173", + "type": "gene", + "text": "The current study defines the vinculin - and FAK - interaction domains on paxillin and identifies the principal paxillin focal adhesion targeting motif .", + "entities": [ + "vinculin", + "FAK - interaction domains", + "paxillin", + "paxillin" + ] + }, + { + "id": "2174", + "type": "gene", + "text": "The expression of ERV3 env mRNA was found to be differentiation - associated , with high expression detected in the late stages of monocytic development .", + "entities": [ + "ERV3 env mRNA" + ] + }, + { + "id": "2175", + "type": "gene", + "text": "USA 80 , 802 - 806 ] was used to isolate a genomic clone lambda PGK - 1 containing a portion of an autosomal locus for phosphoglycerate kinase ( PGK ) .", + "entities": [ + "PGK - 1", + "phosphoglycerate kinase", + "PGK" + ] + }, + { + "id": "2176", + "type": "gene", + "text": "To elucidate the functional significance of Fyn in the expression of viral promoters , we transfected a Fyn - expression vector together with a reporter plasmid containing the chloramphenicol acetyltransferase gene driven by HIV LTR into a human T cell line , Jurkat .", + "entities": [ + "Fyn", + "Fyn", + "chloramphenicol acetyltransferase gene", + "HIV LTR" + ] + }, + { + "id": "2177", + "type": "gene", + "text": "OBJECTIVES : The aim of the study was to analyze the clinical characteristics , treatment and outcome of 310 patients with hydatidiform mole .", + "entities": [] + }, + { + "id": "2178", + "type": "gene", + "text": "Two protease - resistant fragments spanning the N - and C - terminal halves of the nuclease were identified using different proteases which cleave the protein in the same region .", + "entities": [] + }, + { + "id": "2179", + "type": "gene", + "text": "The effect of iron intake on 59Fe absorption throughout pregnancy , and on maternal and fetal Fe status towards the end of pregnancy , was investigated in rats .", + "entities": [] + }, + { + "id": "2180", + "type": "gene", + "text": "BACKGROUND : To determine the predictors of desipramine - refractory depression , the authors examined the outcome in patients with major depression who were admitted to a general hospital and treated with desipramine adjusted to an adequate blood level .", + "entities": [] + }, + { + "id": "2181", + "type": "gene", + "text": "Wave cybernetics : A simple model of wave - controlled nonlinear and nonlocal cooperative phenomena .", + "entities": [] + }, + { + "id": "2182", + "type": "gene", + "text": "FEV1 did not fall significantly in patients without acute or chronic GVHD and recovered earlier than in patients without posttransplant pulmonary infection .", + "entities": [] + }, + { + "id": "2183", + "type": "gene", + "text": "In addition to that , she received hepatic intra - arterial infusion of levoforinate ( l - LV ) 250 mg and 5 - fluorouracil ( 5 - FU ) 500 mg for combined multiple hepatic metastases starting on postoperative day 14 , and these medications were administered over 48 hours once weekly by infuser pump .", + "entities": [] + }, + { + "id": "2184", + "type": "gene", + "text": "Shc stimulates Ras / mitogen - activated protein kinase ( MAPK ) through forming a complex with Grb2 at the phosphorylated tyrosine ( Y ) residue 317 .", + "entities": [ + "Shc", + "Ras", + "mitogen - activated protein kinase", + "MAPK", + "Grb2" + ] + }, + { + "id": "2185", + "type": "gene", + "text": "E . , Scott , J .", + "entities": [] + }, + { + "id": "2186", + "type": "gene", + "text": "Screening of asthma patients by determination of IgE and by comprehension of spectrum of allergospecific IgE antibodies", + "entities": [ + "IgE" + ] + }, + { + "id": "2187", + "type": "gene", + "text": "Comparative mapping of the Brassica S locus region and its homeolog in Arabidopsis .", + "entities": [ + "Brassica S locus region" + ] + }, + { + "id": "2188", + "type": "gene", + "text": "Significant GMBF reductions occurred in early shock in both treatment groups .", + "entities": [] + }, + { + "id": "2189", + "type": "gene", + "text": "Surprisingly , 3 full - length murine survivin cDNA clones were isolated , predicting the existence of 3 distinct survivin proteins .", + "entities": [ + "full - length murine survivin cDNA", + "survivin proteins" + ] + }, + { + "id": "2190", + "type": "gene", + "text": "35 patients with acute arterial occlusions [ 27 ] and graft thromboses [ 8 ] , responsible for severe and recent ischemia , were treated by fibrinolytic therapy ( Urokinase : 1 000 units / kg / hour , and Lys Plasminogen ) .", + "entities": [ + "Urokinase", + "Plasminogen" + ] + }, + { + "id": "2191", + "type": "gene", + "text": "Denaturation of the simian virus 40 origin of replication mediated by human replication protein A .", + "entities": [ + "human replication protein A" + ] + }, + { + "id": "2192", + "type": "gene", + "text": "Similarities between the hIGFBP - 1 and phosphoenolpyruvate kinase ( PEPCK ) promoters , including regions conferring insulin , glucocorticoid , and cyclic adenosine - monophosphate responses , are consistent with our previous hypothesis that IGFBP - 1 is involved in regulation of glucose metabolism .", + "entities": [ + "hIGFBP - 1", + "phosphoenolpyruvate kinase", + "PEPCK", + "insulin", + "IGFBP - 1" + ] + }, + { + "id": "2193", + "type": "gene", + "text": "Our results showed that compared to the primary photon fluence , the extra - focal photon fluence from the primary collimator and the flattening filter was 11 % - 16 % at the isocenter , among which 70 % was contributed by the flattening filter .", + "entities": [] + }, + { + "id": "2194", + "type": "gene", + "text": "The predicted amino acid sequence of the SGC1 gene product includes a region with substantial similarity to the basic - helix - loop - helix domain of the Myc family of DNA - binding proteins .", + "entities": [ + "SGC1 gene product", + "Myc family" + ] + }, + { + "id": "2195", + "type": "gene", + "text": "I propose that their gene products bind to the chromatin to establish or maintain a proper higher order structure as a prerequisite for a regulated gene expression .", + "entities": [] + }, + { + "id": "2196", + "type": "gene", + "text": "This complex interacts at the GTPase domain in the large subunit rRNA , overlapping the binding site of the protein L11 - like eukaryotic counterpart ( Saccharomyces cerevisiae protein L15 and mammalian protein L12 ) .", + "entities": [ + "GTPase domain", + "protein L11 - like eukaryotic counterpart", + "Saccharomyces cerevisiae protein L15", + "mammalian protein L12" + ] + }, + { + "id": "2197", + "type": "gene", + "text": "Gene 1 has been completely sequenced .", + "entities": [ + "Gene 1" + ] + }, + { + "id": "2198", + "type": "gene", + "text": "The myeloproliferative sarcoma virus ( MPSV ) was derived by passage of Moloney sarcoma virus ( Mo - MuSV ) in adult mice .", + "entities": [] + }, + { + "id": "2199", + "type": "gene", + "text": "The 1 . 7 kb cloned fragment was sequenced and shown to contain the entire fliA gene .", + "entities": [ + "fliA gene" + ] + }, + { + "id": "2200", + "type": "gene", + "text": "We have previously shown that LBP - 1 represses HIV - 1 transcription by inhibiting the binding of TFIID to the TATA box .", + "entities": [ + "LBP - 1", + "TFIID" + ] + }, + { + "id": "2201", + "type": "gene", + "text": "Instead , it contained two tandem kappaB elements and a variant activating transcription factor / cAMP response element site , which closely resembled sites in the E - selectin gene that are required for TNF - alpha - or LPS - inducible expression .", + "entities": [ + "kappaB elements", + "activating transcription factor / cAMP response element", + "E - selectin gene", + "TNF - alpha" + ] + }, + { + "id": "2202", + "type": "gene", + "text": "Among known flea larvae , the genus Anomiopsyllus ( Anomiopsyllinae , Anomiopsyllini ) is as distinctive in larval form as are the adults .", + "entities": [] + }, + { + "id": "2203", + "type": "gene", + "text": "B - myb is essential for G1 / S transition and has been shown to be phosphorylated by the cyclin A2 / cdk2 complex .", + "entities": [ + "B - myb", + "cyclin A2", + "cdk2" + ] + }, + { + "id": "2204", + "type": "gene", + "text": "( 1980 ) : Science 210 , 77 - 72 ) that stimulating the crossed olivocochlear bundle ( COCB ) can change the magnitude of the distortion product ( f2 - f1 ) in the ear - canal sound pressure .", + "entities": [] + }, + { + "id": "2205", + "type": "gene", + "text": "Mutating a potential cleavage site located N - terminal to the protease domain , Gln2526 - Asp2527 , diminished processing .", + "entities": [] + }, + { + "id": "2206", + "type": "gene", + "text": "At the time of the seizure , the patient was asked to read a test phrase aloud until it was read correctly and clearly .", + "entities": [] + }, + { + "id": "2207", + "type": "gene", + "text": "Biological activities of hematopoietic growth factors that lead to future clinical application .", + "entities": [ + "hematopoietic growth factors" + ] + }, + { + "id": "2208", + "type": "gene", + "text": "Also discussed is the possibility of a combined genetic and environmental etiology .", + "entities": [] + }, + { + "id": "2209", + "type": "gene", + "text": "Ectopic expression of the dominant mutant Lg3 allele is believed to cause the phenotype .", + "entities": [ + "dominant mutant Lg3 allele" + ] + }, + { + "id": "2210", + "type": "gene", + "text": "The genome of avian erythroblastosis virus contains two independently expressed genetic loci ( v - erbA and v - erbB ) whose activities are probably responsible for oncogenesis by the virus .", + "entities": [ + "v - erbA", + "v - erbB" + ] + }, + { + "id": "2211", + "type": "gene", + "text": "Mean rCBF increased in some patients 4 - 8 weeks after surgery on the ipsilateral side .", + "entities": [] + }, + { + "id": "2212", + "type": "gene", + "text": "The inhibition of StAR gene transcription by DAX - 1 was dose - dependent reducing transcription to 6 % of control levels .", + "entities": [ + "StAR gene", + "DAX - 1" + ] + }, + { + "id": "2213", + "type": "gene", + "text": "Furthermore , an upstream element , collagen element I ( - 370 / - 344 ) , which shares homology with the LAP binding cis - element of the albumin promoter ( 9 of 13 bp ) is described .", + "entities": [ + "collagen element I ( - 370 / - 344 )", + "LAP", + "albumin promoter" + ] + }, + { + "id": "2214", + "type": "gene", + "text": "Cellular Csk was associated with several phosphoproteins , some of which were interacting with the Csk SH2 domain .", + "entities": [ + "Cellular Csk", + "SH2 domain" + ] + }, + { + "id": "2215", + "type": "gene", + "text": "Complete nucleotide sequence of the bacteriophage K1F tail gene encoding endo - N - acylneuraminidase ( endo - N ) and comparison to an endo - N homolog in bacteriophage PK1E .", + "entities": [ + "bacteriophage K1F tail gene", + "endo - N - acylneuraminidase", + "endo - N", + "endo - N homolog" + ] + }, + { + "id": "2216", + "type": "gene", + "text": "Self - heating after deep hypothermia ( 20 degrees C ) causes a considerable increase in the brain tissues glutaminase activity at all studied incubation temperatures ( 37 , 30 , 20 and 10 degrees C ) as compared to control rats and rats under hypothermia .", + "entities": [ + "glutaminase" + ] + }, + { + "id": "2217", + "type": "gene", + "text": "Chronic renal failure patients essentially die from cardiovascular causes , and the frequency of malignant disease responsible for death is estimated to be 10 % .", + "entities": [] + }, + { + "id": "2218", + "type": "gene", + "text": "Mammalian M - Ras and a Caenorhabditis elegans orthologue exhibit conserved structural features , and these are likely to mediate activation of distinctive signaling paths that function in parallel to those downstream of p21 Ras .", + "entities": [ + "Mammalian M - Ras", + "p21 Ras" + ] + }, + { + "id": "2219", + "type": "gene", + "text": "Transient transfection analysis with these mutations revealed that only a 10 - bp region , containing precisely the Ets and proximal LyF - 1 binding sites , was needed for D ' activity .", + "entities": [ + "Ets", + "LyF - 1 binding sites" + ] + }, + { + "id": "2220", + "type": "gene", + "text": "Here we report the cloning of the protein that binds to enhancer site III .", + "entities": [] + }, + { + "id": "2221", + "type": "gene", + "text": "The transcription start point of the proximal promoter aligns to that of mouse promoter P3 and lies within a conserved region of sequence .", + "entities": [] + }, + { + "id": "2222", + "type": "gene", + "text": "The BAL - to - plasma specific activity of urea was about twice that of Na + , indicating that urea diffused into the ELF more rapidly than Na + during the 70 s that elapsed between the time the radioactive urea and Na + were injected into the circulation and the time when lavage was complete .", + "entities": [] + }, + { + "id": "2223", + "type": "gene", + "text": "Certain characteristics of eye changes in patients with pheochromocytoma including Sipple ' s syndrome", + "entities": [] + }, + { + "id": "2224", + "type": "gene", + "text": "In 10 control sheep mean plasma TXB2 concentration increased from 0 . 39 ng / ml prebypass to about 1 . 1 ng / ml at 8 and 16 min of bypass .", + "entities": [] + }, + { + "id": "2225", + "type": "gene", + "text": "Compared to white - on - white ( W - W ) perimetry , SWAP is limited clinically by : greater variability associated with the estimation of threshold , ocular media absorption , increased examination duration and an additional learning effect .", + "entities": [] + }, + { + "id": "2226", + "type": "gene", + "text": "Efficacy and safety of aspirin in the long - term management of atherothrombosis .", + "entities": [] + }, + { + "id": "2227", + "type": "gene", + "text": "However , three Hm1 mutants that were moderately deficient in stimulating PI turnover displayed normal sequestration , suggesting distinct mechanisms .", + "entities": [ + "Hm1 mutants" + ] + }, + { + "id": "2228", + "type": "gene", + "text": "When the PHT and CSA groups were compared , Hyp levels were significantly higher in the PHT - GO + group than in the CSA - GO + group .", + "entities": [] + }, + { + "id": "2229", + "type": "gene", + "text": "Erythromycin and clindamycin resistance in Corynebacterium diphtheriae from skin lesions .", + "entities": [] + }, + { + "id": "2230", + "type": "gene", + "text": "Typical configurations of psychosocial stress factors of psychiatrically conspicuous children and adolescents", + "entities": [] + }, + { + "id": "2231", + "type": "gene", + "text": "Mutations affecting only CD4 regulation mapped to residues previously shown to mediate the binding of Nef to this receptor , such as W57 and L58 , as well as to an AP - recruiting dileucine motif and to an acidic dipeptide in the C - terminal region of the protein .", + "entities": [ + "CD4", + "Nef", + "AP - recruiting dileucine motif" + ] + }, + { + "id": "2232", + "type": "gene", + "text": "Generally the differences between short gut and sham operation animals disappeared when the data were normalised for mucosal weight .", + "entities": [] + }, + { + "id": "2233", + "type": "gene", + "text": "A total of 281 patients were divided into groups according to their clinical diagnosis and were examined using capnography , spirometry and blood - gas analysis .", + "entities": [] + }, + { + "id": "2234", + "type": "gene", + "text": "A .", + "entities": [] + }, + { + "id": "2235", + "type": "gene", + "text": "The incompatibility group W plasmid pSa suppresses Agrobacterium tumefaciens oncogenicity ( J .", + "entities": [] + }, + { + "id": "2236", + "type": "gene", + "text": "Several lines of evidence demonstrate that this growth inhibition requires active PKA subunits and cAMP : ( i ) this phenotype is dependent on cAMP since it is not seen in a strain lacking adenylyl cyclase activity , but the growth rate of these transformants is slower when exogenous cAMP is added ; ( ii ) normal growth occurs when wild - type RI cDNA is replaced by a mutant RI cDNA encoding a RI protein with reduced cAMP binding ; and ( iii ) the growth - inhibited phenotype of the transformed BL21 ( DE3 ) cells requires soluble , active C alpha protein .", + "entities": [ + "PKA subunits", + "adenylyl cyclase", + "RI", + "mutant RI cDNA", + "RI protein", + "C alpha protein" + ] + }, + { + "id": "2237", + "type": "gene", + "text": "Molecular characterization of malignant melanoma of soft parts or soft tissue clear cell sarcoma which shares t ( 12 ; 22 ) chromosome translocation revealed fusion of EWS with a transcriptional factor gene ATF - 1 .", + "entities": [ + "EWS", + "gene ATF - 1" + ] + }, + { + "id": "2238", + "type": "gene", + "text": "Kinetics of the inhibition indicated that this polymerase domain can inhibit viral replication only during the preinitiation stage .", + "entities": [] + }, + { + "id": "2239", + "type": "gene", + "text": "The structural gene for copper - and topa quinone - containing monoamine oxidase ( maoA ) and an unknown amine oxidase gene have been located at 30 . 9 min on the Escherichia coli chromosome .", + "entities": [ + "copper - and topa quinone - containing monoamine oxidase", + "maoA", + "amine oxidase gene" + ] + }, + { + "id": "2240", + "type": "gene", + "text": "The natural history of these lesions , locoregional efficiency of the different treatments used , the part played by chemotherapy , survival , causes of death and therapeutic modalities used as a last measure , have been analysed .", + "entities": [] + }, + { + "id": "2241", + "type": "gene", + "text": "The effects of Codonopsis pilosula oral liquor ( CPOL ) on tissue - type plasminogen activator ( t - PA ) and plasminogen activator inhibitor ( PAI ) in the plasma of 25 patients of coronary heart disease with blood stasis were studied .", + "entities": [ + "tissue - type plasminogen activator", + "t - PA", + "plasminogen activator inhibitor", + "PAI" + ] + }, + { + "id": "2242", + "type": "gene", + "text": "Serum lipid changes during pregnancy due to oral calcium administration", + "entities": [] + }, + { + "id": "2243", + "type": "gene", + "text": "The minimal region of overlap of Langer - Giedion syndrome deletions , previously identified by analysis of 15 patients , was placed on the map by analysis of 2 patients whose deletions define the endpoints .", + "entities": [] + }, + { + "id": "2244", + "type": "gene", + "text": "ALT levels in responders were lowered by 46 % and AST levels were lowered by 35 % after 12 weeks of vitamin E treatment .", + "entities": [ + "ALT", + "AST" + ] + }, + { + "id": "2245", + "type": "gene", + "text": "The mEmBP - 1 protein can activate transcription from a truncated promoter containing a pentamer of the O2 site in yeast cells ; however , it inhibited regulated transcription of a 22 kDa zein promoter in a transient expression assay using cultured maize endosperm cells .", + "entities": [ + "mEmBP - 1 protein", + "O2 site", + "22 kDa zein promoter" + ] + }, + { + "id": "2246", + "type": "gene", + "text": "A region of the deduced protein shares extensive homology with a catalytic region of Raf kinases , a feature shared only with TFIIE among transcription factors .", + "entities": [ + "Raf kinases", + "TFIIE" + ] + }, + { + "id": "2247", + "type": "gene", + "text": "Nerve growth factor ( NGF ) and retinoic acid ( RA ) exert important actions on PC12 cells .", + "entities": [ + "Nerve growth factor", + "NGF" + ] + }, + { + "id": "2248", + "type": "gene", + "text": "In the last case , both hydroxychloroquine , carbamazepine and fluvoxamine had a common imputability which was plausible .", + "entities": [] + }, + { + "id": "2249", + "type": "gene", + "text": "Studies in mammalian cells have correlated induction of inhibitory tyrosine 15 ( Y15 ) phosphorylation on p34cdc2 with the response to DNA damage .", + "entities": [ + "p34cdc2" + ] + }, + { + "id": "2250", + "type": "gene", + "text": "The perifascicular connective tissue sheath is important in organising the contraction of the myocardium by preventing lateral spread of conduction and by permitting transmission of the impulse only at the termination of the purkinje fibre .", + "entities": [] + }, + { + "id": "2251", + "type": "gene", + "text": "Using the balloon - gas procedure with a single gas injection , a bubble was obtained that was large enough to tamponade a giant tear without prior drainage of subretinal fluid or vitrectomy .", + "entities": [] + }, + { + "id": "2252", + "type": "gene", + "text": "Suppressive therapy for thyroid nodules .", + "entities": [] + }, + { + "id": "2253", + "type": "gene", + "text": "Folded tissue and crimped collagen fibers in the tunica albuginea permit its expansion during erection .", + "entities": [ + "collagen" + ] + }, + { + "id": "2254", + "type": "gene", + "text": "This virus is not merely a South African strain of passion fruit woodiness virus ( PWV ) : the deduced CP sequence is only distantly related to CPs of other sequenced strains of PWV , although it is part of a distinct subgroup of potyviruses related to PWV .", + "entities": [ + "CP sequence", + "CPs" + ] + }, + { + "id": "2255", + "type": "gene", + "text": "Osteoadherin is a recently described bone proteoglycan containing keratan sulfate .", + "entities": [ + "Osteoadherin" + ] + }, + { + "id": "2256", + "type": "gene", + "text": "Malonate decarboxylation in Malonomonas rubra involves the formation of malonyl - S - [ acyl - carrier protein ] from acetyl - S - [ acyl - carrier protein ] and malonate , carboxyltransfer to a biotin protein and its decarboxylation that is coupled to delta mu Na + generation .", + "entities": [ + "malonyl - S - [ acyl - carrier protein ]", + "acetyl - S - [ acyl - carrier protein ]", + "biotin protein" + ] + }, + { + "id": "2257", + "type": "gene", + "text": "No patient had a history of excess alcohol intake , or prolonged intake of hepatotoxic drugs and steroids , and were not obese or malnourished .", + "entities": [] + }, + { + "id": "2258", + "type": "gene", + "text": "The results show that cognitive stimulation enhanced performance on the Boston Naming Test and a Word List Recognition Task ; physical intervention , however , did not reach statistical significance .", + "entities": [] + }, + { + "id": "2259", + "type": "gene", + "text": "The effectiveness of the haemodialysate Solcoseryl for second - intention wound healing in horses and ponies .", + "entities": [] + }, + { + "id": "2260", + "type": "gene", + "text": "The result suggests that this non - invasive TTD method is easily available and useful in monitoring the intraoperative cardiac output .", + "entities": [] + }, + { + "id": "2261", + "type": "gene", + "text": "In contrast to T cells , in fibroblasts PILOT gene expression requires only one signal ( PMA ) and is not affected by CyA .", + "entities": [ + "PILOT gene" + ] + }, + { + "id": "2262", + "type": "gene", + "text": "The interindividual variability of the parameters is taken into consideration by interactively determining the threshold levels .", + "entities": [] + }, + { + "id": "2263", + "type": "gene", + "text": "The ED30 values were 2 . 4 and 2 . 2 mg / kg and similar to the respective values of nifedipine ( ED 30 : 2 . 4 , 2 . 1 mg / kg ) .", + "entities": [] + }, + { + "id": "2264", + "type": "gene", + "text": "Together , our results show that tinman is controlled by an array of discrete enhancer elements that are activated successively by differential genetic inputs , as well as by closely linked activator and repressor binding sites within an early - acting enhancer , which restrict twist activity to specific areas within the twist expression domain .", + "entities": [ + "tinman", + "twist", + "twist expression domain" + ] + }, + { + "id": "2265", + "type": "gene", + "text": "Choice of vessel .", + "entities": [] + }, + { + "id": "2266", + "type": "gene", + "text": "The ligand for RXR , 9 - cis retinoic acid , has the opposite effect of destabilizing the heterodimeric - DNA complex .", + "entities": [ + "RXR" + ] + }, + { + "id": "2267", + "type": "gene", + "text": "The latter method adds clamping of the inferior vena cava , which results in hypotension , requiring invasive anesthetic management .", + "entities": [] + }, + { + "id": "2268", + "type": "gene", + "text": "P . , Peyron , J .", + "entities": [] + }, + { + "id": "2269", + "type": "gene", + "text": "The gene for the RNA - dependent eIF - 2 alpha protein kinase ( PKR ) was isolated from mouse genomic DNA and characterized .", + "entities": [ + "RNA - dependent eIF - 2 alpha protein kinase", + "PKR" + ] + }, + { + "id": "2270", + "type": "gene", + "text": "Expression of p130 ( Cas ) ( Cas ) , a major binding protein for the Crk SH2 - domain , also induced JNK activation , which was blocked by the SH2 - mutant of Crk .", + "entities": [ + "p130", + "Cas", + "Cas", + "SH2 - domain", + "JNK", + "SH2 - mutant", + "Crk" + ] + }, + { + "id": "2271", + "type": "gene", + "text": "Microvessels were counted in a x200 field ( 0 . 754 mm2 ) in the area of maximal angiogenesis .", + "entities": [] + }, + { + "id": "2272", + "type": "gene", + "text": "Our studies also excluded the possibility that the phosphorylation of Ser - 2 , Ser - 123 , or Ser - 210 , had roles in the trans - suppression activity of the large HDAg , in the assembly of empty virus - like HDAg particle , and in the nuclear transport of HDAgs .", + "entities": [ + "large HDAg", + "virus - like HDAg particle", + "HDAgs" + ] + }, + { + "id": "2273", + "type": "gene", + "text": "SAECG , echocardiography and thallium - 201 imaging were performed before and 1 month after attempted angioplasty .", + "entities": [] + }, + { + "id": "2274", + "type": "gene", + "text": "Activation of transcription through the AP - 1 site in Jurkat cells by JunD and / or Fra - 2 was weak .", + "entities": [ + "AP - 1 site", + "JunD", + "Fra - 2" + ] + }, + { + "id": "2275", + "type": "gene", + "text": "c - Jun , JunB , and c - Fos activation was greater , although the level was still less than that with Tax .", + "entities": [ + "c - Jun", + "JunB", + "c - Fos", + "Tax" + ] + }, + { + "id": "2276", + "type": "gene", + "text": "The decline in the activity of cytochrome oxidase , peroxidase and in the lipid content of peripheral neutrophils was followed by a decrease in the phagocytic activity .", + "entities": [ + "cytochrome oxidase", + "peroxidase" + ] + }, + { + "id": "2277", + "type": "gene", + "text": "For the first time we describe deletion and point mutations within the plasma membrane family of guanylyl cyclase receptors that result in the formation of effective dominant negative proteins .", + "entities": [ + "plasma membrane family of guanylyl cyclase receptors" + ] + }, + { + "id": "2278", + "type": "gene", + "text": "Both in vitro - synthesized S2 protein and synthetic peptides corresponding to S2 are shown to react positively with sera obtained from EIAV - infected horses , providing the first direct evidence of expression of this protein in infected animals .", + "entities": [ + "S2 protein", + "S2" + ] + }, + { + "id": "2279", + "type": "gene", + "text": "188 patients received cimetidine 400 mg q . i . d . intravenously and 1 , 000 mg daily orally in divided doses .", + "entities": [] + }, + { + "id": "2280", + "type": "gene", + "text": "A genetic screen in yeast has allowed us to identify a novel transcriptional factor binding to the GlRE , i . e . the chicken ovalbumin upstream promoter - transcription factor II ( COUP - TFII ) .", + "entities": [ + "chicken ovalbumin upstream promoter - transcription factor II", + "COUP - TFII" + ] + }, + { + "id": "2281", + "type": "gene", + "text": "A hospital - based study of the relationship between retained placenta and mastitis in dairy cows .", + "entities": [] + }, + { + "id": "2282", + "type": "gene", + "text": "The effects of intracisternal injection ( i . c . i . ) of clonidine ( 1 microgram kg - 1 ) on blood pressure and heart rate were studied in conscious rabbits with an implanted catheter in the cisterna magna .", + "entities": [] + }, + { + "id": "2283", + "type": "gene", + "text": "Copyright 2001 Academic Press .", + "entities": [] + }, + { + "id": "2284", + "type": "gene", + "text": "9 , 1498 - 1506 ) .", + "entities": [] + }, + { + "id": "2285", + "type": "gene", + "text": "These studies demonstrate that site - specific recognition of the bxd PRE by d ( GA ) ( n ) repeat binding activities mediates PcG - dependent silencing .", + "entities": [ + "bxd PRE", + "PcG" + ] + }, + { + "id": "2286", + "type": "gene", + "text": "Initial experience with the new technology indicates that SieScape is an alternative to other methods such as CT and MRI .", + "entities": [] + }, + { + "id": "2287", + "type": "gene", + "text": "BACKGROUND : In the ubiquitin - dependent proteolysis pathway , a ubiquitin ligase ( E3 ) is responsible for substrate selectivity and timing of degradation .", + "entities": [ + "ubiquitin", + "ubiquitin ligase", + "E3" + ] + }, + { + "id": "2288", + "type": "gene", + "text": "Studies using HLA - DR - B7 - 1 - LFA - 3 triple transfectants showed that the LFA - 3 - induced NF - AT DNA binding activity was negatively regulated by B7 - 1 costimulation .", + "entities": [ + "HLA - DR", + "B7 - 1", + "LFA - 3", + "LFA - 3", + "NF - AT", + "B7 - 1" + ] + }, + { + "id": "2289", + "type": "gene", + "text": "In the present study , lesions of the OPT complex ( the thalamic source of afferents to IHA and HD ) were found to have no effect on color - reversal learning performance .", + "entities": [] + }, + { + "id": "2290", + "type": "gene", + "text": "However , further analyses of the data indicate that increasing VO2 AT ( r = - 0 . 63 , P less than 0 . 05 ) rather than VO2max ( r = - 0 . 15 ) could result in improving the 10 , 000 m race performance to a larger extent , and that the absolute amount of change ( delta ) in the 10 , 000 m run time is best accounted for by a combination of delta VO2 AT and delta 5 , 000 m run time .", + "entities": [] + }, + { + "id": "2291", + "type": "gene", + "text": "By order of decreasing rate , finger flexors , jaw , crossed adductors , and triceps reflexes were less frequently elicited in both groups .", + "entities": [] + }, + { + "id": "2292", + "type": "gene", + "text": "Intravenous L - carnitine treatment increased plasma carnitine concentrations , improved patient - assessed fatigue , and may prevent the decline in peak exercise capacity in hemodialysis patients .", + "entities": [] + }, + { + "id": "2293", + "type": "gene", + "text": "The shift in the earliest activation site after administration of esmolol was compared with the shift after RFA .", + "entities": [] + }, + { + "id": "2294", + "type": "gene", + "text": "RESULTS : The heart rate at rest and in drug - free state ranged between 95 and 125 beats / min ( mean 99 + / - 14 beats / min ) .", + "entities": [] + }, + { + "id": "2295", + "type": "gene", + "text": "To evaluate the gas chromatographic electron capture detection method described earlier , 23 plasma samples have been analysed by both techniques .", + "entities": [] + }, + { + "id": "2296", + "type": "gene", + "text": "The TUP1 gene was isolated in a screen for genes that regulate mating type ( V . L .", + "entities": [ + "TUP1 gene" + ] + }, + { + "id": "2297", + "type": "gene", + "text": "Angiography was performed following the rCBF study and the degree of vasospasm was measured on the angiograms .", + "entities": [] + }, + { + "id": "2298", + "type": "gene", + "text": "A marked decrease in the type 1 insulin - like growth factor ( IGF ) receptor ( IGF - IR ) occurs in prostate epithelial cells during transformation from the benign to the metastatic state .", + "entities": [ + "type 1 insulin - like growth factor ( IGF ) receptor", + "IGF - IR" + ] + }, + { + "id": "2299", + "type": "gene", + "text": "The detection of ORF - 1 sequences in human tumors , while not proof per se , is a prerequisite for establishing its role in tumor development .", + "entities": [ + "ORF - 1" + ] + }, + { + "id": "2300", + "type": "gene", + "text": "The results revealed a hierarchy of ligand affinities that mirrored their adhesive activity ( rsVCAM - 1 > fibronectin variants containing CS1 > > other fibronectin variants ) .", + "entities": [ + "rsVCAM - 1", + "fibronectin variants", + "CS1", + "fibronectin variants" + ] + }, + { + "id": "2301", + "type": "gene", + "text": "These data suggest that proper direct binding of Nhp2p to H / ACA snoRNAs is required for the assembly of H / ACA snoRNPs and hence for the stability of some of their components .", + "entities": [ + "Nhp2p", + "H / ACA snoRNAs", + "H / ACA snoRNPs" + ] + }, + { + "id": "2302", + "type": "gene", + "text": "These results indicate that the p33 subunit of eIF3 plays an important role in the initiation phase of protein synthesis and that its RNA - binding domain is required for optimal activity .", + "entities": [ + "p33 subunit", + "eIF3" + ] + }, + { + "id": "2303", + "type": "gene", + "text": "Clinicopathologic studies in feminizing tumors of the ovary .", + "entities": [] + }, + { + "id": "2304", + "type": "gene", + "text": "In contrast , the differentiation of neoplastically transformed cells does not repress mitogenic responsiveness or junB or c - fos inducibility .", + "entities": [ + "junB", + "c - fos" + ] + }, + { + "id": "2305", + "type": "gene", + "text": "Data from the V - HeFT II show that at 2 - year follow - up , a progressive rise of plasma norepinephrine was observed in both treatment arms , suggesting that disease progresses despite treatment with either an angiotensin - converting enzyme inhibitor , enalapril , or vasodilator therapy with hydralazine / isosorbide dinitrate .", + "entities": [ + "angiotensin - converting enzyme" + ] + }, + { + "id": "2306", + "type": "gene", + "text": "Recombinant soluble pMCP that lacked transmembrane and cytoplasmic domains had factor I cofactor activity in C3b cleavage , indicating that it is functionally , as well as structurally homologous to MCP .", + "entities": [ + "Recombinant soluble pMCP", + "factor I cofactor", + "C3b", + "MCP" + ] + }, + { + "id": "2307", + "type": "gene", + "text": "All 89 participating household members were anti - HIV seronegative , and 78 who were tested were serum p24 antigen negative .", + "entities": [ + "anti - HIV", + "serum p24 antigen" + ] + }, + { + "id": "2308", + "type": "gene", + "text": "The most important finding , however , was that IMT values were related with 24 h SBP or PP standard deviation ( P < 0 . 001 ) , a measure of overall SBP or PP variability .", + "entities": [] + }, + { + "id": "2309", + "type": "gene", + "text": "One of the most relevant aspects in achieving the consistent survival of an animal undergoing the experimental implantation of a total artificial heart is obviously related to the correct anatomic placement of prosthetic ventricles inside the chest .", + "entities": [] + }, + { + "id": "2310", + "type": "gene", + "text": "Phenylephrine is a pure alpha - 1 adrenoreceptor agonist known to produce marked systemic vasoconstriction and associated hypertension with occasional profound reflex bradycardia .", + "entities": [ + "alpha - 1 adrenoreceptor" + ] + }, + { + "id": "2311", + "type": "gene", + "text": "Expression of this cDNA in vitro yields a peptide which comigrates with natural eIF - 2B alpha in SDS / polyacrylamide gels .", + "entities": [ + "natural eIF - 2B alpha" + ] + }, + { + "id": "2312", + "type": "gene", + "text": "Biological properties of sumithion .", + "entities": [] + }, + { + "id": "2313", + "type": "gene", + "text": "Analysis of the sequences with the BLAST and GRAIL programs provided additional independent evidence that 15 of these 17 clones contain coding sequences and that nine other clones are likely to contain sequences coding for portions of new genes .", + "entities": [] + }, + { + "id": "2314", + "type": "gene", + "text": "The interpretation of antibiotic disc sensitivities .", + "entities": [] + }, + { + "id": "2315", + "type": "gene", + "text": "The data presented in this work indicate that thi1 may also be involved in DNA damage tolerance in plant cells .", + "entities": [ + "thi1" + ] + }, + { + "id": "2316", + "type": "gene", + "text": "A comparative analysis of the reported MOCT - associated malignant melanomas emphasizes the singularity of our case in the amelanotic character of the melanoma , its lymphotropism and the coexistence of invasive squamous cell carcinoma .", + "entities": [] + }, + { + "id": "2317", + "type": "gene", + "text": "If this is present , such patients should be closely monitored , and any atypical lesions biopsied .", + "entities": [] + }, + { + "id": "2318", + "type": "gene", + "text": "In Group V , the salvaged tissue was primarily subepicardial with virtually no lateral zone of salvaged tissue ( ratio of salvaged subepicardium to salvaged subendocardium 14 . 8 + / - 1 . 9 to 1 ) .", + "entities": [] + }, + { + "id": "2319", + "type": "gene", + "text": "The results of this study demonstrate that strongyloidiasis was the cause of sudden death .", + "entities": [] + }, + { + "id": "2320", + "type": "gene", + "text": "In summary , the segments of C3 represented by amino acid residues 1082 - 1118 , 1117 - 1155 , 1234 - 1294 and 1312 - 1404 accommodate C3 ( D ) epitopes that are expressed by erythrocyte - bound C3 fragments , but not by the corresponding fluid - phase fragment , whereas the segments spanning residues 973 - 1026 and 1477 - 1510 contain C3 ( D ) epitopes that are exposed exclusively in denatured C3 and therefore hidden in physiological fragments of the protein .", + "entities": [ + "C3", + "C3 ( D ) epitopes", + "C3 fragments", + "C3 ( D ) epitopes", + "C3" + ] + }, + { + "id": "2321", + "type": "gene", + "text": "Effects of thromboxane synthetase inhibition on postburn mesenteric vascular resistance and the rate of bacterial translocation in a chronic porcine model .", + "entities": [ + "thromboxane synthetase" + ] + }, + { + "id": "2322", + "type": "gene", + "text": "Interleukin - 6 may possibly potentiate metastasis of cardiac myxoma .", + "entities": [ + "Interleukin - 6" + ] + }, + { + "id": "2323", + "type": "gene", + "text": "However , a > 10 - fold increase in ERK3 activity in each PKC beta transfectant was shown by immunoprecipitation with anti - ERK3 monoclonal antibody followed by either immune complex kinase assay or by in gel kinase assay .", + "entities": [ + "ERK3", + "PKC beta", + "anti - ERK3 monoclonal antibody" + ] + }, + { + "id": "2324", + "type": "gene", + "text": "This study suggests that PSP is more common than previously considered , is commonly misdiagnosed and that the majority of cases are not initially referred to neurologists .", + "entities": [] + }, + { + "id": "2325", + "type": "gene", + "text": "These data suggest that : ( a ) proSRIF cleavage is initiated in the TGN , and ( b ) this reaction requires an acidic pH which is facilitated by a Golgi - associated vacuolar - type ATPase .", + "entities": [ + "proSRIF", + "Golgi - associated vacuolar - type ATPase" + ] + }, + { + "id": "2326", + "type": "gene", + "text": "Regulated activity of the distal promoter - like element of the human corticotropin - releasing hormone gene and secondary structural features of its corresponding transcripts .", + "entities": [ + "human corticotropin - releasing hormone gene" + ] + }, + { + "id": "2327", + "type": "gene", + "text": "After one accommodation night , sleep EEG recordings were performed during three consecutive nights in ten drug - free inpatients presenting generalized anxiety disorder ( GAD ) with significant depression , compared with a age - and sex - matched group of patients with GAD and a group of primary major depressive disorder ( MDD ) patients .", + "entities": [] + }, + { + "id": "2328", + "type": "gene", + "text": "The effects of antithrombotic drugs in patients with left ventricular thrombi : assessment with indium - 111 platelet imaging and two - dimensional echocardiography .", + "entities": [] + }, + { + "id": "2329", + "type": "gene", + "text": "In this paper , an analysis of the dynamics in the closing phase of the occluder of a mechanical monoleaflet heart valve prosthesis is presented .", + "entities": [] + }, + { + "id": "2330", + "type": "gene", + "text": "The impact of social support on the relationships of gay male couples is examined .", + "entities": [] + }, + { + "id": "2331", + "type": "gene", + "text": "TPTA produced brain congestion , and hepatic and pulmonary petechial and generalized hemorrhages .", + "entities": [] + }, + { + "id": "2332", + "type": "gene", + "text": "After allowing time for absorption , participants completed a bridge simulator task .", + "entities": [] + }, + { + "id": "2333", + "type": "gene", + "text": "The validity of the FPS - R was further supported by strong positive correlations with the VAS ( r = 0 . 92 , N = 45 ) and the CAS ( r = 0 . 84 , N = 45 ) in this clinical sample .", + "entities": [] + }, + { + "id": "2334", + "type": "gene", + "text": "Skin and bowel TPO2 varied with DO2 and each other ( P < 0 . 05 ) .", + "entities": [] + }, + { + "id": "2335", + "type": "gene", + "text": "Most other end points were highly significant , and death , which was monitored across the U . S . program , was different with p < 0 . 0001 .", + "entities": [] + }, + { + "id": "2336", + "type": "gene", + "text": "Presidential address 1990 - - coming in from the cold .", + "entities": [] + }, + { + "id": "2337", + "type": "gene", + "text": "Hb levels remained adequate ( Hb = 10 . 68 + / - 0 . 77 g / dl ) after 14 . 6 + / - 7 . 64 months .", + "entities": [ + "Hb", + "Hb" + ] + }, + { + "id": "2338", + "type": "gene", + "text": "Structure and expression of a gene from Arabidopsis thaliana encoding a protein related to SNF1 protein kinase .", + "entities": [ + "SNF1" + ] + }, + { + "id": "2339", + "type": "gene", + "text": "Phase II trial of the anti - G ( D2 ) monoclonal antibody 3F8 and granulocyte - macrophage colony - stimulating factor for neuroblastoma .", + "entities": [ + "anti - G ( D2 ) monoclonal antibody 3F8", + "granulocyte - macrophage colony - stimulating factor" + ] + }, + { + "id": "2340", + "type": "gene", + "text": "The purpose of this study was to develop a reliable and culturally meaningful exercise self - efficacy questionnaire for older Mexican American women .", + "entities": [] + }, + { + "id": "2341", + "type": "gene", + "text": "Interestingly , the avirulent strain H37Ra showed weak hybridization with these two probes , suggesting that these genes might have been deleted in the avirulent strain or are present in limited copy numbers as opposed to those in the virulent strain H37Rv .", + "entities": [] + }, + { + "id": "2342", + "type": "gene", + "text": "Two out of five patients undergoing selective spinal arteriography developed transient neurological complications during the injection of Urografin 310 M .", + "entities": [] + }, + { + "id": "2343", + "type": "gene", + "text": "However , in some of them either pattern may predominate or be exclusively present .", + "entities": [] + }, + { + "id": "2344", + "type": "gene", + "text": "Albumin dialysis : effective removal of copper in a patient with fulminant Wilson disease and successful bridging to liver transplantation : a new possibility for the elimination of protein - bound toxins .", + "entities": [ + "Albumin" + ] + }, + { + "id": "2345", + "type": "gene", + "text": "Epidemiologic evidence indicates that estrogen replacement therapy after menopause increases breast cancer risk .", + "entities": [] + }, + { + "id": "2346", + "type": "gene", + "text": "Statokinesimetric recording in Huntington choreas", + "entities": [] + }, + { + "id": "2347", + "type": "gene", + "text": "The yeast MMS2 gene was cloned by its ability to complement the methyl methanesulfonate sensitivity of the mms2 - 1 mutant and was later shown to be involved in DNA post - replication repair .", + "entities": [ + "yeast MMS2 gene", + "mms2 - 1 mutant" + ] + }, + { + "id": "2348", + "type": "gene", + "text": "RESULTS : Transpulmonary passage of contrast occurred in sufficient amounts to enhance the intensity of the Doppler signal significantly , but the duration of this effect was short .", + "entities": [] + }, + { + "id": "2349", + "type": "gene", + "text": "Static orthoses for the management of microstomia .", + "entities": [] + }, + { + "id": "2350", + "type": "gene", + "text": "Caution should be exercised in the use of these dyes for lymphograms .", + "entities": [] + }, + { + "id": "2351", + "type": "gene", + "text": "The characterized Aplysia Afurin2 is a candidate PC that may play an important role in the processing of egg - laying hormone ( ELH ) - related precursors in the secretory cells of the atrial gland .", + "entities": [ + "Aplysia Afurin2", + "PC", + "egg - laying hormone", + "ELH" + ] + }, + { + "id": "2352", + "type": "gene", + "text": "Extreme potency of botulinum toxin .", + "entities": [ + "botulinum toxin" + ] + }, + { + "id": "2353", + "type": "gene", + "text": "Identification of an AfsA homologue ( BarX ) from Streptomyces virginiae as a pleiotropic regulator controlling autoregulator biosynthesis , virginiamycin biosynthesis and virginiamycin M1 resistance .", + "entities": [ + "AfsA homologue", + "BarX" + ] + }, + { + "id": "2354", + "type": "gene", + "text": "Overexpression of CDP / cut in ROS 17 / 2 . 8 osteosarcoma cells results in repression of OC promoter activity ; this repression is abrogated by mutating OC box I .", + "entities": [ + "CDP", + "cut", + "OC promoter", + "OC box I" + ] + }, + { + "id": "2355", + "type": "gene", + "text": "The amino - terminal half of 1a is a distant homolog of alphavirus nonstructural protein nsP1 , which has been implicated in capping viral RNAs .", + "entities": [ + "1a", + "homolog of alphavirus nonstructural protein nsP1" + ] + }, + { + "id": "2356", + "type": "gene", + "text": "MAIN OUTCOME MEASURES : Associations of factor analysis - derived syndromes with risk factors for chemical interactions that inhibit butyrylcholinesterase and neuropathy target esterase .", + "entities": [ + "butyrylcholinesterase", + "esterase" + ] + }, + { + "id": "2357", + "type": "gene", + "text": "We have cloned and sequenced COX12 , the nuclear gene for subunit VIb of Saccharomyces cerevisiae cytochrome c oxidase .", + "entities": [ + "COX12", + "subunit VIb", + "Saccharomyces cerevisiae cytochrome c oxidase" + ] + }, + { + "id": "2358", + "type": "gene", + "text": "Cyclin D1 could not be displaced from cdk4 in the resistant 184A1L5R cell lysates .", + "entities": [ + "Cyclin D1", + "cdk4" + ] + }, + { + "id": "2359", + "type": "gene", + "text": "First , human erythroid K562 cells stably integrated with various HS - 40 mutants cis linked to a human alpha - globin promoter - growth hormone hybrid gene were analyzed by genomic footprinting and expression analysis .", + "entities": [ + "HS - 40 mutants", + "human alpha - globin promoter", + "growth hormone" + ] + }, + { + "id": "2360", + "type": "gene", + "text": "The presence of unidentified macroscopic or microscopic clusters of neoplastic cells , lying around , more or less close to , the line of insertion of lesion , could render any attempt to gain a \" radical \" excision useless .", + "entities": [] + }, + { + "id": "2361", + "type": "gene", + "text": "By screening a Y1 cell cDNA library with the DNA - binding region of the H - 2RIIBP nuclear hormone receptor cDNA , we isolated a cDNA that is selectively expressed in steroidogenic cells .", + "entities": [ + "H - 2RIIBP nuclear hormone receptor cDNA" + ] + }, + { + "id": "2362", + "type": "gene", + "text": "Induction of B cell apoptosis by co - cross - linking CD23 and sIg involves aberrant regulation of c - myc and is inhibited by bcl - 2 .", + "entities": [ + "CD23", + "sIg", + "c - myc", + "bcl - 2" + ] + }, + { + "id": "2363", + "type": "gene", + "text": "The structure has been established by a study of its mono - and bidimensional NMR spectra and mass spectrometry .", + "entities": [] + }, + { + "id": "2364", + "type": "gene", + "text": "Increased PTHRP production by a tyrosine kinase oncogene , Tpr - Met : role of the Ras signaling pathway .", + "entities": [ + "PTHRP", + "tyrosine kinase oncogene", + "Tpr - Met", + "Ras" + ] + }, + { + "id": "2365", + "type": "gene", + "text": "It was subsequently shown that Tip60 had histone acetyltransferase ( HAT ) activity .", + "entities": [ + "Tip60", + "histone acetyltransferase", + "HAT" + ] + }, + { + "id": "2366", + "type": "gene", + "text": "The repression domain , and indeed the entire Cdc68 protein , is highly conserved , as shown by the sequence of the Cdc68 functional homolog from the yeast Kluyveromyces lactis and by database searches .", + "entities": [ + "Cdc68 protein", + "Cdc68 functional homolog" + ] + }, + { + "id": "2367", + "type": "gene", + "text": "In a retrospective analysis of data from 35 cases with malignant lymphoma from a cohort of 2017 HIV - infected patients , the stage of HIV - disease , the CD4 counts at the time of diagnosis , and the use of antineoplastic agents or radiotherapy were correlated with outcome .", + "entities": [ + "CD4" + ] + }, + { + "id": "2368", + "type": "gene", + "text": "Brain cholinesterase activity of nestling great egrets , snowy egrets and black - crowned night - herons . inhibition of brain cholinesterase ( ChE ) activity in birds is often used to diagnose exposure or death from organophosphorus or carbamate pesticides .", + "entities": [ + "Brain cholinesterase", + "brain cholinesterase", + "ChE" + ] + }, + { + "id": "2369", + "type": "gene", + "text": "Microwave hyperthermia - induced blood - brain barrier alterations .", + "entities": [] + }, + { + "id": "2370", + "type": "gene", + "text": "What to look for during a compliance review : 10 common mistakes made by SNFs .", + "entities": [] + }, + { + "id": "2371", + "type": "gene", + "text": "Is more better ?", + "entities": [] + }, + { + "id": "2372", + "type": "gene", + "text": "About dose levels of ACE inhibitors in chronic heart failure .", + "entities": [ + "ACE" + ] + }, + { + "id": "2373", + "type": "gene", + "text": "The upstream delta - alpha breakpoint is flanked by the direct repeats of the acceptor splice site , whereas the down - stream alpha - delta breakpoint is located in the adjacent intron .", + "entities": [] + }, + { + "id": "2374", + "type": "gene", + "text": "By contrast , PvirE or Plac promoter constructs yielded functional VirE2 only if virE1 was coexpressed with virE2 .", + "entities": [ + "PvirE", + "Plac promoter constructs", + "VirE2", + "virE1", + "virE2" + ] + }, + { + "id": "2375", + "type": "gene", + "text": "Ovaries of 10 animals per group from 16 studies in CD - 1 mice and 1 study each in C3H and C57BL / 6 mice were sectioned serially at 6 microm .", + "entities": [] + }, + { + "id": "2376", + "type": "gene", + "text": "Epstein - Barr virus ( EBV ) latent membrane protein 1 ( LMP1 ) is essential for EBV - mediated transformation of primary B lymphocytes .", + "entities": [ + "Epstein - Barr virus ( EBV ) latent membrane protein 1", + "LMP1" + ] + }, + { + "id": "2377", + "type": "gene", + "text": "Expression is exclusively limited to the CNS at this and later stages .", + "entities": [] + }, + { + "id": "2378", + "type": "gene", + "text": "The DRF - 2 nuclear protein has characteristics similar to those of the muscle - specific regulatory factor , MEF - 2 ( Buskin and Hauschka 1989 ; Gossett et al . , 1989 ) .", + "entities": [ + "DRF - 2 nuclear protein", + "MEF - 2" + ] + }, + { + "id": "2379", + "type": "gene", + "text": "Parathyroid hormone regulation of bone sialoprotein ( BSP ) gene transcription is mediated through a pituitary - specific transcription factor - 1 ( Pit - 1 ) motif in the rat BSP gene promoter .", + "entities": [ + "Parathyroid hormone", + "bone sialoprotein", + "BSP", + "pituitary - specific transcription factor - 1", + "Pit - 1", + "rat BSP gene promoter" + ] + }, + { + "id": "2380", + "type": "gene", + "text": "A mail survey of Georgia members of the American College of Obstetricians and Gynecologists was conducted .", + "entities": [] + }, + { + "id": "2381", + "type": "gene", + "text": "Effects of a selective monoamine oxidase ( MAO ) - - A inhibitor , clorgyline , a selective MAO - B inhibitor , deprenyl , and a non - selective MAO inhibitor , nialamide , were investigated on footshock - induced aggression ( FIA ) in paired rats .", + "entities": [ + "monoamine oxidase ( MAO ) - - A", + "MAO - B", + "MAO" + ] + }, + { + "id": "2382", + "type": "gene", + "text": "Proctoscopy and roentgenographic studies may be an important part of evaluation , especially in patients who present with perianal suppuration , masses , or anal fissures .", + "entities": [] + }, + { + "id": "2383", + "type": "gene", + "text": "Results of electron therapy of tumors in different sites", + "entities": [] + }, + { + "id": "2384", + "type": "gene", + "text": "The 96 - bp insert contained a termination signal which caused the premature termination of the protein , leading to the generation of a p53 product 9 amino acids shorter than usual .", + "entities": [ + "p53 product" + ] + }, + { + "id": "2385", + "type": "gene", + "text": "Critical residues required for repression are located within the C - terminal 27 amino acids of c - Fos , since v - Fos and C - terminal truncations of c - Fos did not down regulate .", + "entities": [ + "c - Fos", + "v - Fos", + "c - Fos" + ] + }, + { + "id": "2386", + "type": "gene", + "text": "Thus , diamide treatment of nuclear extracts strongly reduces the binding of NFI proteins , and the addition of higher concentrations of dithiothreitol to nuclear extracts from TG - treated cells restores NFI - DNA binding to levels in extracts from untreated cells .", + "entities": [ + "NFI proteins", + "TG", + "NFI - DNA" + ] + }, + { + "id": "2387", + "type": "gene", + "text": "These studies indicate that in vitro and in vivo electrical stimulation generate reactive oxygen species and affect SOD activity , which in part are responsible for decreased sperm motion and viability .", + "entities": [ + "SOD" + ] + }, + { + "id": "2388", + "type": "gene", + "text": "These REPs , or clusters of paralogous loci , are 15 - 100 kb and harbor at least four ESTs and an expressed SH3GL pseudogene .", + "entities": [ + "SH3GL pseudogene" + ] + }, + { + "id": "2389", + "type": "gene", + "text": "METHOD : 50 consecutive children aged from 6 months to 17 years were included into the study which comprised questionnaires of patient and family histories , serological screening tests for common inhalational allergens ( CAP SX1 ) , and determination of total serum immunoglobulin E ( IgE ) and of latex - specific serum IgE by solid - phase immunoassays .", + "entities": [ + "serum immunoglobulin E", + "IgE", + "serum IgE" + ] + }, + { + "id": "2390", + "type": "gene", + "text": "Effects of negative pleural pressure on left ventricular hemodynamics .", + "entities": [] + }, + { + "id": "2391", + "type": "gene", + "text": "Cross - linking the B cell Ag receptor ( BCR ) to surface Fc receptors for IgG ( Fc gamma R ) inhibits G1 - to - S progression ; the mechanism by which this occurs is not completely known .", + "entities": [ + "B cell Ag receptor", + "BCR", + "surface Fc receptors", + "IgG", + "Fc gamma R" + ] + }, + { + "id": "2392", + "type": "gene", + "text": "TE - 671 cells that were transfected with cAMP response element mutant constructs demonstrated a diminished basal activity of the GnRH - II promoter .", + "entities": [ + "GnRH - II promoter" + ] + }, + { + "id": "2393", + "type": "gene", + "text": "Acupuncture effect on deep receptors was not limited to one point but within a certain area , namely distant effect existed .", + "entities": [] + }, + { + "id": "2394", + "type": "gene", + "text": "Twenty patients aged 45 or older with the diagnosis of endogenous depression were evaluated in terms of safety and efficacy in their response to multiple monitored electroconvulsive therapy ( MMECT ) versus single electroconvulsive therapy ( SECT ) .", + "entities": [] + }, + { + "id": "2395", + "type": "gene", + "text": "In wandering stage larvae , the OBP transcript appeared to be at least 250 - fold less abundant than ribosomal RNA .", + "entities": [ + "OBP transcript" + ] + }, + { + "id": "2396", + "type": "gene", + "text": "In C . albicans , HST6 is expressed constitutively at high levels in the different cell types analysed ( yeast , hyphae , white and opaque ) , demonstrating that HST6 transcription is not repressed in this diploid yeast , unlike in diploid S . cerevisiae , and suggesting a basic biological function for the Hst6p transporter in C . albicans .", + "entities": [ + "HST6", + "HST6", + "Hst6p" + ] + }, + { + "id": "2397", + "type": "gene", + "text": "Using the yeast one - hybrid screen with integrated NRE and flanking DNA as bait , the predominant clone obtained was bovine Nrl .", + "entities": [ + "bovine Nrl" + ] + }, + { + "id": "2398", + "type": "gene", + "text": "Serial measurements of total serum IgE appears to be a useful index of disease activity in ABPA .", + "entities": [ + "IgE" + ] + }, + { + "id": "2399", + "type": "gene", + "text": "These effects were not seen with SHIP2 possessing a mutation in the SH2 domain ( R47G ) .", + "entities": [ + "SHIP2", + "SH2 domain", + "R47G" + ] + }, + { + "id": "2400", + "type": "gene", + "text": "Factors affecting the inhibition of phagocytosis by chlorpromazine .", + "entities": [] + }, + { + "id": "2401", + "type": "gene", + "text": "The roll - over test to predict toxemia in pregnancy .", + "entities": [] + }, + { + "id": "2402", + "type": "gene", + "text": "A region in the C - terminus of adenovirus 2 / 5 E1a protein is required for association with a cellular phosphoprotein and important for the negative modulation of T24 - ras mediated transformation , tumorigenesis and metastasis .", + "entities": [ + "adenovirus 2 / 5 E1a protein", + "ras" + ] + }, + { + "id": "2403", + "type": "gene", + "text": "Levels of TSG - 14 protein ( also termed PTX - 3 ) become elevated in the serum of mice and humans after injection with bacterial lipopolysaccharide , but in contrast to conventional acute phase proteins , the bulk of TSG - 14 synthesis in the intact organism occurs outside the liver .", + "entities": [ + "TSG - 14 protein", + "PTX - 3", + "TSG - 14" + ] + }, + { + "id": "2404", + "type": "gene", + "text": "The IE0 gene product also transactivated the IE1 promoter but did not affect expression from its own promoter .", + "entities": [ + "IE0 gene", + "IE1 promoter" + ] + }, + { + "id": "2405", + "type": "gene", + "text": "Methods of clinical and experimental algesimetry are described that have been used to evaluate effects of peripherally and centrally acting analgesics .", + "entities": [] + }, + { + "id": "2406", + "type": "gene", + "text": "Mutational analysis supports a role for multiple structural features in the C - terminal secretion signal of Escherichia coli haemolysin .", + "entities": [ + "Escherichia coli haemolysin" + ] + }, + { + "id": "2407", + "type": "gene", + "text": "Radioimmunoassays of pregnenolone , progesterone , dehydroepiandrosterone ( DHA ) 16 alpha - hydroxy - DHA , estriol , and cortisol were performed on a total of 0 ; 1 ml ; of fetal plasma , collected during the course of normal vaginal delivery .", + "entities": [] + }, + { + "id": "2408", + "type": "gene", + "text": "The 1489 - base pair EFIA cDNA encodes a 322 - amino acid protein which is nearly identical to two previously described human DNA binding proteins .", + "entities": [ + "EFIA" + ] + }, + { + "id": "2409", + "type": "gene", + "text": "Twenty - five patients also received PET examinations during the staging procedures .", + "entities": [] + }, + { + "id": "2410", + "type": "gene", + "text": "The beta subunit of the heterotrimeric G proteins that transduce signals across the plasma membrane is made up of an amino - terminal alpha - helical segment followed by seven repeating units called WD ( Trp - Asp ) repeats that occur in about 140 different proteins .", + "entities": [ + "heterotrimeric G proteins" + ] + }, + { + "id": "2411", + "type": "gene", + "text": "Sequence analysis of the 5 ' - flanking region of the CD69 gene revealed the presence of a potential TATA element 30 base pairs upstream of the major transcription initiation site and several putative binding sequences for inducible transcription factors ( NF - kappa B , Egr - 1 , AP - 1 ) , which might mediate the inducible expression of this gene .", + "entities": [ + "CD69 gene", + "NF - kappa B", + "Egr - 1", + "AP - 1" + ] + }, + { + "id": "2412", + "type": "gene", + "text": "The data show conclusively that phosphorylation of His - 304 is not essential for any of the known functions of A . vinelandii NifL .", + "entities": [ + "A . vinelandii NifL" + ] + }, + { + "id": "2413", + "type": "gene", + "text": "Here we show that short synthetic peptides containing the pRB - binding sequences of E1A are sufficient for interaction with p107 , cyclin A , and p130 .", + "entities": [ + "pRB - binding sequences", + "E1A", + "p107", + "cyclin A", + "p130" + ] + }, + { + "id": "2414", + "type": "gene", + "text": "Ly - 49 is a family type II transmembrane proteins encoded by a gene cluster on murine chromosome 6 .", + "entities": [ + "Ly - 49", + "family type II transmembrane proteins" + ] + }, + { + "id": "2415", + "type": "gene", + "text": "2 were nonviable , and the mutant Vp1s unexpectedly failed to localize to the nucleus though Vp2 and Vp3 did , suggesting that the mutated NLS1 acted as a dominant signal for the cytoplasmic localization of Vp1 .", + "entities": [ + "mutant Vp1s", + "Vp2", + "Vp3", + "mutated NLS1", + "Vp1" + ] + }, + { + "id": "2416", + "type": "gene", + "text": "Furthermore , the soluble forms of ATF6 and the G13 gene product are unable to bind to several point mutants of the cis - acting ER stress response element in vitro that hardly respond to ER stress in vivo .", + "entities": [ + "ATF6", + "G13 gene product" + ] + }, + { + "id": "2417", + "type": "gene", + "text": "To address mechanisms that define interactions of Site II regulatory factors with this cell cycle control element , we have investigated these determinants of transcriptional regulation at the G1 / S phase transition in FDC - P1 hematopoietic progenitor cells .", + "entities": [ + "Site II regulatory factors" + ] + }, + { + "id": "2418", + "type": "gene", + "text": "The functions of isolated portions of the insulin , IAPP , and beta GK promoters were studied by using transient expression and DNA binding assays .", + "entities": [ + "insulin", + "IAPP", + "beta GK promoters" + ] + }, + { + "id": "2419", + "type": "gene", + "text": "Bimodal cochlear response curves in rodents .", + "entities": [] + }, + { + "id": "2420", + "type": "gene", + "text": "In short - term cotransfections , a pFRTK - CAT target containing EBNA - 1 - binding sites from the EBV origin of plasmid replication , ori - P , was transactivated by a carboxy - terminal EBNA - 1 construction ( amino acids 450 to 641 ) that also carried a c - myc nuclear localization signal .", + "entities": [ + "pFRTK", + "CAT", + "EBNA - 1 - binding sites", + "ori - P", + "carboxy - terminal EBNA - 1 construction", + "c - myc nuclear localization signal" + ] + }, + { + "id": "2421", + "type": "gene", + "text": "The amino - terminal DNA - binding domain of Pip exhibits a high degree of homology to the DNA - binding domains of members of the interferon regulatory factor ( IRF ) family , which includes IRF - 1 , IRF - 2 , ICSBP , and ISGF3 gamma .", + "entities": [ + "Pip", + "interferon regulatory factor", + "IRF", + "IRF - 1", + "IRF - 2", + "ICSBP", + "ISGF3 gamma" + ] + }, + { + "id": "2422", + "type": "gene", + "text": "This structure of cucumisin suggests that it is probably synthesized as an inactive precursor .", + "entities": [ + "cucumisin" + ] + }, + { + "id": "2423", + "type": "gene", + "text": "Treatment and care of adult diabetes mellitus without coma", + "entities": [] + }, + { + "id": "2424", + "type": "gene", + "text": "By creating Pax - 6 - BSAP fusion proteins , we were able to identify a short amino acid stretch in the N - terminal part of the paired domain which is responsible for these differences in DNA - binding specificity .", + "entities": [ + "Pax - 6", + "BSAP", + "paired" + ] + }, + { + "id": "2425", + "type": "gene", + "text": "205 , 285 - 290 ] and was subsequently cloned and sequenced [ J .", + "entities": [] + }, + { + "id": "2426", + "type": "gene", + "text": "Long - range mapping of the 11q23 region involved in chromosome aberrations in human tumors by pulsed - field gel electrophoresis with a yeast artificial chromosome .", + "entities": [] + }, + { + "id": "2427", + "type": "gene", + "text": "PO2 measurements using a double barrelled recess type microelectrodes were measured in the optic nerve head of miniature pigs in normoxia and hyperoxia .", + "entities": [] + }, + { + "id": "2428", + "type": "gene", + "text": "O2 and CO2 in the tracheostomy tube were continuously monitored by mass spectrometry using a special sample - hold phase - locked sampling technique .", + "entities": [] + }, + { + "id": "2429", + "type": "gene", + "text": "Finding of Rhodnius prolixus Stal , 1859 , in babassu palm trees", + "entities": [] + }, + { + "id": "2430", + "type": "gene", + "text": "Hybridization analysis showed that the size of the mRNA is about 1 . 4 kilobases .", + "entities": [] + }, + { + "id": "2431", + "type": "gene", + "text": "The active open reading frame in the clone maps at 27 min on the E . coli chromosome and is identical in sequence to a wild type counterpart .", + "entities": [] + }, + { + "id": "2432", + "type": "gene", + "text": "Cortisol excretion , appeared to be markedly affected by the season although other factors such as social and environmental stress cannot be discounted .", + "entities": [] + }, + { + "id": "2433", + "type": "gene", + "text": "Two closely related variants of Stat5 , Stat5a and Stat5b , are encoded by distinct genes .", + "entities": [ + "Stat5", + "Stat5a", + "Stat5b" + ] + }, + { + "id": "2434", + "type": "gene", + "text": "We could demonstrate the involvement of cAMP - dependent protein kinase ( PKA ) in the phosphorylation of CDC25Mm in fibroblasts overexpressing this RasGEF as well as in mouse brain synaptosomal membranes .", + "entities": [ + "cAMP - dependent protein kinase", + "PKA", + "CDC25Mm", + "RasGEF" + ] + }, + { + "id": "2435", + "type": "gene", + "text": "2 .", + "entities": [] + }, + { + "id": "2436", + "type": "gene", + "text": "During transcript elongation , the sizes of the DNA footprint and the single - stranded transcription bubble vary markedly among transcription complexes halted at different template positions .", + "entities": [] + }, + { + "id": "2437", + "type": "gene", + "text": "Direct current polarography and differential pulse polarographic methods have been developed for the qualitative as well as quantitative analysis of vitamin B1 , B2 and B6 .", + "entities": [] + }, + { + "id": "2438", + "type": "gene", + "text": "Overexpressing the coactivator , SRC1a or GRIP1 , further enhances ERRalpha1 - induced transcriptional activity .", + "entities": [ + "SRC1a", + "GRIP1", + "ERRalpha1" + ] + }, + { + "id": "2439", + "type": "gene", + "text": "3 .", + "entities": [] + }, + { + "id": "2440", + "type": "gene", + "text": "Colorectal polyps should be removed endoscopically whenever possible .", + "entities": [] + }, + { + "id": "2441", + "type": "gene", + "text": "In contrast , transcription initiating from opuE P - 1 ( sigma A ) rose in proportion to the external osmolarity and was maintained at high levels .", + "entities": [ + "opuE P - 1", + "sigma A" + ] + }, + { + "id": "2442", + "type": "gene", + "text": "In the base - case analysis , total direct costs per patient were $ 728 for zoledronic acid and $ 776 for pamidronate .", + "entities": [] + }, + { + "id": "2443", + "type": "gene", + "text": "Cells respond to the accumulation of unfolded proteins in the endoplasmic reticulum ( ER ) by increasing the transcription of the genes encoding ER - resident chaperone proteins .", + "entities": [ + "ER - resident chaperone proteins" + ] + }, + { + "id": "2444", + "type": "gene", + "text": "CONCLUSIONS : Free protein S deficiency is common among hospitalized patients , even in the absence of a recognized predisposing condition .", + "entities": [ + "protein S" + ] + }, + { + "id": "2445", + "type": "gene", + "text": "At the basal unstimulated condition , Ren1d 5 ' flanking sequence in the sense orientation inhibited basal CAT expression from the TK promoter of pUTKAT1 , whereas the same sequence in the antisense orientation did not .", + "entities": [ + "Ren1d 5 ' flanking sequence", + "CAT", + "TK promoter" + ] + }, + { + "id": "2446", + "type": "gene", + "text": "Selection of the 22 items of the Clinical Institute Withdrawal Assessment - Benzodiazepines ( CIWA - B ) was based on statistically significant differences between baseline and critical withdrawal periods in high - dose subjects and between symptoms associated with placebo and diazepam in low - dose subjects , using contingency tables and logistic regression analysis .", + "entities": [] + }, + { + "id": "2447", + "type": "gene", + "text": "Cotransfections with ATF - 2 and HNF - 4 expression plasmids resulted in additive transactivation of the apoCIII promoter .", + "entities": [ + "ATF - 2", + "HNF - 4", + "apoCIII promoter" + ] + }, + { + "id": "2448", + "type": "gene", + "text": "Sequence analysis of the 5 ' flanking region revealed several GC boxes but no identifiable TATA box .", + "entities": [] + }, + { + "id": "2449", + "type": "gene", + "text": "The indoor radon concentration in the summer ( 1990 ) period ranged between 8 and 81 Bq m - 3 , while in the winter ( 1989 - 1990 ) it ranged between 20 and 143 Bq m - 3 for the first year of measurements or between 8 and 92 Bq m - 3 in the summer ( 1991 ) period and between 12 and 119 Bq m - 3 in the winter ( 1990 - 1991 ) for the second year of measurements .", + "entities": [] + }, + { + "id": "2450", + "type": "gene", + "text": "Clinical research of non - A , non - B post - transfusion hepatitis", + "entities": [] + }, + { + "id": "2451", + "type": "gene", + "text": "Homozygous individuals usually develop purpura fulminans as newborns ; heterozygous protein C - deficient individuals are at increased risk for venous thrombosis and pulmonary embolism .", + "entities": [ + "protein C" + ] + }, + { + "id": "2452", + "type": "gene", + "text": "This accurate and rapid method makes the MLPA test logistically feasible for large - scale screening .", + "entities": [] + }, + { + "id": "2453", + "type": "gene", + "text": "In a series of 402 consecutive autopsies , parietal pleural plaques ( PP ) were found in 68 individuals above 40 years of age .", + "entities": [] + }, + { + "id": "2454", + "type": "gene", + "text": "While the examiner observed the interior of the eye with indirect ophthalmoscopy , the point source of light from the fiberoptic light pipe was moved along the margins of the episcleral plaque .", + "entities": [] + }, + { + "id": "2455", + "type": "gene", + "text": "Respiratory adaptation to chronic hypoxia in newborn rats .", + "entities": [] + }, + { + "id": "2456", + "type": "gene", + "text": "The amplitude of detrusor contractions at 6 , 12 , and 24 hours showed no significant difference from that in the controls .", + "entities": [] + }, + { + "id": "2457", + "type": "gene", + "text": "2 .", + "entities": [] + }, + { + "id": "2458", + "type": "gene", + "text": "The functional homology of Cwg2 with Cdc43 , which has been implicated in the control of cell polarity , suggests a link between two morphogenetic events such as establishment of cell polarity and cell wall biosynthesis .", + "entities": [ + "Cwg2", + "Cdc43" + ] + }, + { + "id": "2459", + "type": "gene", + "text": "Measurements of perfusion also showed significantly higher values under active therapy .", + "entities": [] + }, + { + "id": "2460", + "type": "gene", + "text": "The dorsal nerves of the penis were anesthetized bilaterally with lidocaine .", + "entities": [] + }, + { + "id": "2461", + "type": "gene", + "text": "One form of the SBEI gene transcript in 12 - day old kernels contained the exon I + II + III combination at the 5 ' end , whereas other forms differed by inclusion of intron 1 or exclusion of exon II sequences .", + "entities": [ + "SBEI gene transcript" + ] + }, + { + "id": "2462", + "type": "gene", + "text": "Age and sex structure of the natural population of Ornithodoros tatarovski Ol .", + "entities": [] + }, + { + "id": "2463", + "type": "gene", + "text": "Their effect on the guinea pig vas deferens .", + "entities": [] + }, + { + "id": "2464", + "type": "gene", + "text": "In summary , the data establish that the previously reported human MAdCAM - 1 cDNA does indeed encode the human homologue of mouse MAdCAM - 1 , despite gross dissimilarities in the MAdCAM - 1 C - terminal structures .", + "entities": [ + "human MAdCAM - 1 cDNA", + "mouse MAdCAM - 1", + "MAdCAM - 1" + ] + }, + { + "id": "2465", + "type": "gene", + "text": "Stably transfected human kidney 293 cells expressing the wild type rat LH / CG receptor ( rLHR ) or receptors with C - terminal tails truncated at residues 653 , 631 , or 628 ( designated rLHR - t653 , rLHR - t631 , and rLHR - t628 ) were used to probe the importance of this region on the regulation of hormonal responsiveness .", + "entities": [ + "wild type rat LH / CG receptor", + "rLHR", + "rLHR - t653", + "rLHR - t631", + "rLHR - t628" + ] + }, + { + "id": "2466", + "type": "gene", + "text": "Although the RAD23 equivalents are well conserved during evolution , the mammalian genes did not express the UV - inducible phenotype of their yeast counterpart .", + "entities": [ + "RAD23" + ] + }, + { + "id": "2467", + "type": "gene", + "text": "Drosophila Menin1 gene transcripts use alternative polyadenylation sites resulting in 4 . 3 and 5 - kb messages .", + "entities": [ + "Drosophila Menin1 gene transcripts" + ] + }, + { + "id": "2468", + "type": "gene", + "text": "Frog type I ( Ft I ) and frog type II ( Ft II ) slowly adapting ( SA ) units produced spikes only at the indentation phase , and the threshold response phase ( TRP ) , i . e . . the phase of the first spike was for ca .", + "entities": [] + }, + { + "id": "2469", + "type": "gene", + "text": "Frog type I ( Ft I ) and frog type II ( Ft II ) slowly adapting ( SA ) units produced spikes only at the indentation phase , and the threshold response phase ( TRP ) , i . e . . the phase of the first spike was for ca .", + "entities": [] + }, + { + "id": "2470", + "type": "gene", + "text": "This agent , isolated from the fungus Streptomyces tsukubaensis , has a mechanism of action similar to that of cyclosporine .", + "entities": [] + }, + { + "id": "2471", + "type": "gene", + "text": "These cells averaged 17 microns in diameter and reproduced by fission , forming clusters of two or four daughter cells .", + "entities": [] + }, + { + "id": "2472", + "type": "gene", + "text": "An RME1 - independent pathway for sporulation control in Saccharomyces cerevisiae acts through IME1 transcript accumulation .", + "entities": [ + "RME1", + "IME1 transcript" + ] + }, + { + "id": "2473", + "type": "gene", + "text": "To investigate the requirements for CBF2 binding , we synthesized a series of oligonucleotides carrying double transversion mutations spanning both the conserved core sequence and outside flanking sequences .", + "entities": [ + "CBF2" + ] + }, + { + "id": "2474", + "type": "gene", + "text": "Control intact rats were age - matched to the different treated groups .", + "entities": [] + }, + { + "id": "2475", + "type": "gene", + "text": "This region constitutes the DNA - binding domain with basic - helix - loop - helix and leucine - zipper motifs , features common to the myc - related transcription factor family .", + "entities": [ + "myc - related transcription factor family" + ] + }, + { + "id": "2476", + "type": "gene", + "text": "After 90 d a subsurface , radiolucent caries - like lesion was observed in two specimens only .", + "entities": [] + }, + { + "id": "2477", + "type": "gene", + "text": "The metabolic clearance rate of progesterone was 295 + / - 49 ( S . E . ) 1 / day .", + "entities": [] + }, + { + "id": "2478", + "type": "gene", + "text": "An F222W : W21F rGST A1 - 1 double mutant provides a direct fluorescence probe of changes in the environment of the C - terminal residue .", + "entities": [ + "F222W : W21F rGST A1 - 1 double mutant" + ] + }, + { + "id": "2479", + "type": "gene", + "text": "Identical effects were obtained when inhibitors and dominant negative mutants were tested on the - 29 to + 139 bp region of the cyclin D1 promoter .", + "entities": [ + "cyclin D1 promoter" + ] + }, + { + "id": "2480", + "type": "gene", + "text": "Deltamethrin was most effective on the thatched surface and produced 100 % mortality of An . culicifacies adults up to 12 weeks , even when exposed at the lowest dose / 12 . 5 mg / m2 .", + "entities": [] + }, + { + "id": "2481", + "type": "gene", + "text": "Concerted action of three distinct domains in the DNA cleaving - joining reaction catalyzed by relaxase ( TraI ) of conjugative plasmid RP4 .", + "entities": [ + "relaxase", + "TraI" + ] + }, + { + "id": "2482", + "type": "gene", + "text": "An approximately 37 - kDa cytoplasmic protein is rapidly tyrosine - phosphorylated in the response of mouse BAC1 . 2F5 macrophages to colony stimulating factor - 1 ( CSF - 1 ) .", + "entities": [ + "colony stimulating factor - 1", + "CSF - 1" + ] + }, + { + "id": "2483", + "type": "gene", + "text": "pp37 was purified from the cytosolic fraction by anti - Tyr ( P ) affinity chromatography , size exclusion chromatography , and C4 reverse phase high pressure liquid chromatography .", + "entities": [ + "pp37", + "anti - Tyr ( P )" + ] + }, + { + "id": "2484", + "type": "gene", + "text": "Both the MVBF and the maximum EMG activity in the right masseter and the left anterior temporalis muscles were significantly decreased during muscle pain when the subjects bit on the painful side .", + "entities": [] + }, + { + "id": "2485", + "type": "gene", + "text": "Early - onset scleral necrosis after iodine I 125 plaque radiotherapy for ciliochoroidal melanoma .", + "entities": [] + }, + { + "id": "2486", + "type": "gene", + "text": "RU486 and ONO 802 in combination have been shown to be effective in early termination of pregnancy .", + "entities": [] + }, + { + "id": "2487", + "type": "gene", + "text": "A preliminary study on pyogenic arthritis .", + "entities": [] + }, + { + "id": "2488", + "type": "gene", + "text": "SAM - TR - 68 - 54 .", + "entities": [] + }, + { + "id": "2489", + "type": "gene", + "text": "A mutational analysis has resolved a region of seven amino acids ( amino acids 26 - 32 ) in the N - terminus of Bob1 that are important for contacting the DNA binding POU domain of Oct - 1 or Oct - 2 .", + "entities": [ + "Bob1", + "DNA binding POU domain", + "Oct - 1", + "Oct - 2" + ] + }, + { + "id": "2490", + "type": "gene", + "text": "High levels of C subunits are observed in several subsequent larval and adult stages of development .", + "entities": [ + "C subunits" + ] + }, + { + "id": "2491", + "type": "gene", + "text": "Thirty Class I and Class II recessions in 30 patients were treated with a modified subepithelial connective tissue graft procedure .", + "entities": [] + }, + { + "id": "2492", + "type": "gene", + "text": "While important for ligand - dependent transactivation , this interaction surface is not directly involved in transrepression of AP - 1 activity .", + "entities": [ + "AP - 1" + ] + }, + { + "id": "2493", + "type": "gene", + "text": "Collectively , these data indicate that HIP is a membrane - associated HP - binding protein expressed on the surface of normal human uterine epithelia and uterine epithelial cell lines .", + "entities": [ + "HIP", + "HP - binding protein" + ] + }, + { + "id": "2494", + "type": "gene", + "text": "Regression line slopes of IBDQ scores were significantly different in patients who deteriorated from those who remained stable ( [ b ] < 0 . 15 ; P < 0 . 0001 ) .", + "entities": [] + }, + { + "id": "2495", + "type": "gene", + "text": "Further research is required to better measure treatment effects , modification of MS natural history , and net societal costs of IFN beta - 1b in RRMS .", + "entities": [ + "IFN beta - 1b" + ] + }, + { + "id": "2496", + "type": "gene", + "text": "These data indicate that the SmSmad2 responds to the TGF - beta signals by interaction with receptor I , which phosphorylates it , whereupon it translocates into the nucleus presumably to regulate target gene transcription and consequently elicit a specific TGF - beta effect .", + "entities": [ + "SmSmad2", + "TGF - beta", + "receptor I", + "TGF - beta" + ] + }, + { + "id": "2497", + "type": "gene", + "text": "Mapping the cAMP receptor protein contact site on the alpha subunit of Escherichia coli RNA polymerase .", + "entities": [ + "cAMP receptor protein contact site", + "Escherichia coli RNA polymerase" + ] + }, + { + "id": "2498", + "type": "gene", + "text": "These temperature - and cold - sensitive strains were used to prepare extracts deficient in BRF1 activity and were tested for transcriptional activity by RNA polymerases I , II , and III in vitro .", + "entities": [ + "BRF1", + "RNA polymerases I , II , and III" + ] + }, + { + "id": "2499", + "type": "gene", + "text": "Blood glucose and plasma insulin were measured at zero time and then at 15 , 30 , 60 , 90 and 120 min after ingestion of 25 g glucose , fructose or lactose , or 30 g honey , 50 g white bread , 125 g white rice or potatoes , 150 g apples or 260 g carrots .", + "entities": [ + "insulin" + ] + }, + { + "id": "2500", + "type": "gene", + "text": "The preferential heterodimerization of USF subunits was reproduced ex vivo , while the in vitro association of cotranslated subunits , or recombinant USF proteins , appeared to be random .", + "entities": [ + "USF subunits", + "recombinant USF proteins" + ] + }, + { + "id": "2501", + "type": "gene", + "text": "Following 2 . 5 Gy , HbO2 changes were minimal .", + "entities": [ + "HbO2" + ] + }, + { + "id": "2502", + "type": "gene", + "text": "The corticosterone synthesis inhibitor metyrapone ( 75 mg / kg i . p . ) was given to attenuate the rise of corticosterone to a level typical of stressed males .", + "entities": [] + }, + { + "id": "2503", + "type": "gene", + "text": "The centromeric YAC contig , which consists of 23 overlapping YACs and orders 19 sequence - tagged sites ( STSs ) , covers a minimum of 2 . 2 Mb and spans the Ewing sarcoma breakpoint .", + "entities": [] + }, + { + "id": "2504", + "type": "gene", + "text": "c - ets 1 and Fli - 1 , two members of the ets family , have been linked within 400 kb of intervening DNA within this contig , which also comprises a polymorphic microsatellite , D11S912 ( CA ) n , which we have localized within the Fli - 1 gene .", + "entities": [ + "c - ets 1", + "Fli - 1", + "ets family", + "D11S912", + "Fli - 1 gene" + ] + }, + { + "id": "2505", + "type": "gene", + "text": "Blood variables measured at eight intervals before , during , and after operation were as follows : seven plasma proteins , free hemoglobin , formed elements , and clotting functions .", + "entities": [ + "hemoglobin" + ] + }, + { + "id": "2506", + "type": "gene", + "text": "Both antidepressants elevated the pain threshold acutely , while pretreatment with pCPA largely blocked the analgesia .", + "entities": [] + }, + { + "id": "2507", + "type": "gene", + "text": "All Cu values obtained from the organs investigated had reached a saturation level at 8 mug Cu / g diet with the exception of the values for body Cu found in the dams that were killed on the day of delivery .", + "entities": [] + }, + { + "id": "2508", + "type": "gene", + "text": "Precision measurement of the pion mass difference m pi - - m pi 0 .", + "entities": [] + }, + { + "id": "2509", + "type": "gene", + "text": "Gel electrophoresis and Western immunoblot analyses of intracellular fractions derived from infected cells revealed that large amounts of NS53 were present in the cytosol and in association with the cytoskeletal matrix .", + "entities": [ + "NS53" + ] + }, + { + "id": "2510", + "type": "gene", + "text": "The Southern technique allowed a further localization of the region of most extensive transcription to a 1 . 8 kb HindIII - EcoRI fragment .", + "entities": [ + "HindIII", + "EcoRI" + ] + }, + { + "id": "2511", + "type": "gene", + "text": "Grippers with integrated piezoresistive force sensors and with attached strain gauges have been reported .", + "entities": [] + }, + { + "id": "2512", + "type": "gene", + "text": "Streptococcal preparation ( OK - 432 ) , a new type of anti - cancer agent , was given to the patients with advanced cancer in combination with Mitomycin - C , 5 - FU and Cytosine arabinoside .", + "entities": [] + }, + { + "id": "2513", + "type": "gene", + "text": "Fifty min after release from stress , increases in plasma corticosterone levels induced by stress recovered in the biting group but remained high in the non - biting group .", + "entities": [] + }, + { + "id": "2514", + "type": "gene", + "text": "The critical mutations were likely to have been multiple and dispersed , including elongation of the TM and Nef coding sequences ; changes in RNA splice donor and acceptor sites , TATA box sites , and Sp1 sites ; multiple changes in the V2 region of SU , including a consensus neutralization epitope ; and five new N - linked glycosylation sites in SU .", + "entities": [ + "Nef coding sequences", + "Sp1 sites", + "V2", + "SU", + "SU" + ] + }, + { + "id": "2515", + "type": "gene", + "text": "\" Complex partial \" seizures .", + "entities": [] + }, + { + "id": "2516", + "type": "gene", + "text": "Retreatment of these 2 dogs resulted in a similar , but blunted , response to human immunoglobulin .", + "entities": [ + "human immunoglobulin" + ] + }, + { + "id": "2517", + "type": "gene", + "text": "Forty - one ASA physical status I or II adult patients undergoing a variety of 1 - 1 . 5 h surgical procedures were randomly allocated to receive CCA with desflurane or isoflurane with ventilation being either spontaneous or controlled .", + "entities": [] + }, + { + "id": "2518", + "type": "gene", + "text": "In MCCP functions of the source emission , surface reflection , photoacceptor sensitivity are approximated by the normal distribution curves .", + "entities": [] + }, + { + "id": "2519", + "type": "gene", + "text": "A recently described protein , metaxin 1 , serves as a component of a preprotein import complex in the outer membrane of the mammalian mitochondrion .", + "entities": [ + "metaxin 1" + ] + }, + { + "id": "2520", + "type": "gene", + "text": "The metabolism and pharmacology of 5 - fluorouracil .", + "entities": [] + }, + { + "id": "2521", + "type": "gene", + "text": "Jean Klig reviews recent literature about lower respiratory tract infection in children .", + "entities": [] + }, + { + "id": "2522", + "type": "gene", + "text": "Total PGE levels in synovial fluid remained significantly depressed in the patient group for 24 hours after the 400 - mg test dose of tolmetin on day 8 .", + "entities": [] + }, + { + "id": "2523", + "type": "gene", + "text": "However , both TPN groups showed a marked increase in activities of liver lysosomal enzymes .", + "entities": [ + "lysosomal enzymes" + ] + }, + { + "id": "2524", + "type": "gene", + "text": "Overexpression of CARP in cardiomyocytes suppresses cardiac troponin C and atrial natriuretic factor transcription .", + "entities": [ + "CARP", + "cardiac troponin C", + "atrial natriuretic factor" + ] + }, + { + "id": "2525", + "type": "gene", + "text": "This repressor is however unlikely to mediate spi 2 . 3 3 ' UTR silencer action since it was not detected in rat hepatocytes .", + "entities": [ + "spi 2 . 3 3 ' UTR silencer" + ] + }, + { + "id": "2526", + "type": "gene", + "text": "Molecular analysis of a novel schizosaccharomyces pombe gene containing two RNP consensus - sequence RNA - binding domains .", + "entities": [] + }, + { + "id": "2527", + "type": "gene", + "text": "The number of muricidal rats increased with increase in the duration of Cd administration in association with greater accumulation of Cd in the olfactory bulb than in any other region of the brain .", + "entities": [] + }, + { + "id": "2528", + "type": "gene", + "text": "The syndrome of resistance to thyroid hormone is characterized by elevated serum free thyroid hormones , failure to suppress pituitary thyrotropin secretion , and variable peripheral refractoriness to hormone action .", + "entities": [ + "pituitary thyrotropin" + ] + }, + { + "id": "2529", + "type": "gene", + "text": "Human homologue of yeast Rad23 protein A interacts with p300 / cyclic AMP - responsive element binding ( CREB ) - binding protein to down - regulate transcriptional activity of p53 .", + "entities": [ + "Human homologue of yeast Rad23 protein A", + "p300", + "cyclic AMP - responsive element binding ( CREB ) - binding protein", + "p53" + ] + }, + { + "id": "2530", + "type": "gene", + "text": "Can thyroglobulin assay really supplant radioiodine scans in patients with differentiated thyroid cancer ?", + "entities": [ + "thyroglobulin" + ] + }, + { + "id": "2531", + "type": "gene", + "text": "A receptor - like protein kinase , OsPK10 , has been cloned from rice ( Oryza sativa ) .", + "entities": [ + "receptor - like protein kinase", + "OsPK10" + ] + }, + { + "id": "2532", + "type": "gene", + "text": "Effect of triftazin and aminazin on hippocampal bioelectric activity", + "entities": [] + }, + { + "id": "2533", + "type": "gene", + "text": "Analysis of strains harboring an mds1 null mutation demonstrates that MDS1 is not essential during normal vegetative growth but appears to be required for meiosis .", + "entities": [ + "mds1 null mutation", + "MDS1" + ] + }, + { + "id": "2534", + "type": "gene", + "text": "Autoregulation enables different pathways to control CCAAT / enhancer binding protein beta ( C / EBP beta ) transcription .", + "entities": [ + "CCAAT / enhancer binding protein beta", + "C / EBP beta" + ] + }, + { + "id": "2535", + "type": "gene", + "text": "Bacterial recovery of SA from the liver / spleen and the cecal tonsil in contact poults and SG from contact chicks treated with ILK was dramatically reduced when compared to non - treated contact poults and chicks .", + "entities": [ + "ILK" + ] + }, + { + "id": "2536", + "type": "gene", + "text": "Clinical chemistry .", + "entities": [] + }, + { + "id": "2537", + "type": "gene", + "text": "Consistent with this , purified Dlk phosphorylated core histones H3 , H2A and H4 as exogenous substrates and endogenous histone H3 in kinase assays with nuclear extracts .", + "entities": [ + "Dlk", + "histones H3", + "H2A", + "H4", + "histone H3" + ] + }, + { + "id": "2538", + "type": "gene", + "text": "Transcriptional regulation of the estrogen - inducible pS2 breast cancer marker gene by the ERR family of orphan nuclear receptors .", + "entities": [ + "breast cancer marker gene", + "ERR family", + "orphan nuclear receptors" + ] + }, + { + "id": "2539", + "type": "gene", + "text": "We have developed a new method for estimation of regional CBF ( rCBF ) and cerebrovascular reserve capacity on a pixel - by - pixel basis by means of dynamic magnetic resonance imaging ( MRI ) .", + "entities": [] + }, + { + "id": "2540", + "type": "gene", + "text": "XXI .", + "entities": [] + }, + { + "id": "2541", + "type": "gene", + "text": "A preliminary study of vincristine , methotrexate , and prednisolone ( VM * P ) combination chemotherapy for advanced adult non - Hodgkin ' s lymphoma", + "entities": [] + }, + { + "id": "2542", + "type": "gene", + "text": "Seventeen of the 35 patients were randomly chosen to receive a training program ( lasting approximately 1 month ) designed to establish a systematic strategy of organizing complex visual material .", + "entities": [] + }, + { + "id": "2543", + "type": "gene", + "text": "We have thus identified the first mammalian homolog of yeast UPF1 , a protein that regulates levels of nonsense mRNA , and we tentatively name this protein human HUPF1 ( for human homolog of UPF1 ) .", + "entities": [ + "mammalian homolog of yeast UPF1", + "human HUPF1", + "human homolog of UPF1" + ] + }, + { + "id": "2544", + "type": "gene", + "text": "Pathogenetic relationships between renal tubular acidosis and sodium metabolism alterations in liver cirrhosis .", + "entities": [] + }, + { + "id": "2545", + "type": "gene", + "text": "CDK4 kinase activities were unaffected , as were the levels of the CDK inhibitor p21Cip1 present in cyclin E immunocomplexes .", + "entities": [ + "CDK4 kinase", + "CDK", + "p21Cip1", + "cyclin E immunocomplexes" + ] + }, + { + "id": "2546", + "type": "gene", + "text": "The serum insulin response cannot .", + "entities": [ + "serum insulin" + ] + }, + { + "id": "2547", + "type": "gene", + "text": "Data collection was made with a query language , and data analysis performed with an interactive knowledge - based statistical tool , MAXITAB , employing a multivariate tabular analysis technique .", + "entities": [] + }, + { + "id": "2548", + "type": "gene", + "text": "The objective of our study was to evaluate the age , sex , clinical conditions , family history , site , catheter association , means of radiologic evaluation , development of pulmonary involvement , prevalence of antithrombin III , protein C and protein S deficiencies , and lupus anticoagulants in children who suffered a thrombotic event .", + "entities": [ + "antithrombin III", + "protein C", + "protein S" + ] + }, + { + "id": "2549", + "type": "gene", + "text": "After description of his short life and an explanation of the light conductor Bozzini ' s merit is emphasized , by his invention as first physician to have made accessible to medicine endoscopic diagnostic possibilities .", + "entities": [] + }, + { + "id": "2550", + "type": "gene", + "text": "In both groups there were 5 management failure of therapy , so that alternative medication or a cesarean section lead to delivery .", + "entities": [] + }, + { + "id": "2551", + "type": "gene", + "text": "We have introduced a mutation ( Ser36 - - > Asn ) into this domain of p190 that decreased its ability to bind guanine nucleotide when expressed as a hemagglutinin ( HA ) - tagged protein in COS cells .", + "entities": [ + "p190", + "hemagglutinin", + "HA" + ] + }, + { + "id": "2552", + "type": "gene", + "text": "Laser therapy of penile carcinoma", + "entities": [] + }, + { + "id": "2553", + "type": "gene", + "text": "Type 2 genomes containing this sequence presumably more closely reflect the structure of the infectious , replication - competent retrovirus ancestors of the HERV - K family than do type 1 genomes that lack the sequence .", + "entities": [] + }, + { + "id": "2554", + "type": "gene", + "text": "DNA binding and glutathione S - transferase pull - down assays demonstrate that binding requires Elk - 1 ( 1 - 212 ) but not the C - terminal transactivation domain .", + "entities": [ + "glutathione S - transferase", + "Elk - 1 ( 1 - 212 )" + ] + }, + { + "id": "2555", + "type": "gene", + "text": "One millimolar ouabain completely inhibited net HCO3 - secretion .", + "entities": [] + }, + { + "id": "2556", + "type": "gene", + "text": "The psychological tests consisted of a free - recall task , a test for visuomotor coordination and a recognition task .", + "entities": [] + }, + { + "id": "2557", + "type": "gene", + "text": "Of the compounds tested , alpha - ( 3 - methyl - 2 - quinoxalinyl ) - N - methylnitrone 1 , 4 - dioxide ( 2 ) was the most active agent in vivo against the gram - negative and the gram - positive organisms .", + "entities": [] + }, + { + "id": "2558", + "type": "gene", + "text": "Effects of moderate hypercapnia on hypothermia induced by cold He - O2 in rats .", + "entities": [] + }, + { + "id": "2559", + "type": "gene", + "text": "The HSD3B1 and HSD3B2 genes encoding the types I and II 3 beta - HSD isoenzymes , respectively , have been previously assigned by in situ hybridization to the chromosome 1p13 . 1 region .", + "entities": [ + "HSD3B1", + "HSD3B2 genes", + "types I and II 3 beta - HSD isoenzymes" + ] + }, + { + "id": "2560", + "type": "gene", + "text": "The persistence of members of the prostigmatid families Tydeidae , Nanorchestidae and Tarsonemidae in the moisture - deficient 90 % - concentration treatments supports previous evidence of adaptations to low - water - content habitats .", + "entities": [] + }, + { + "id": "2561", + "type": "gene", + "text": "In the intact animal , postextrasystolic potentiation depended on the basic pacing interval , t0 , and the timing of the extrasystole , t1 : when t0 was held constant and t1 was increased , potentiation decreased ; when t1 was held constant and t0 was increased , potentiation increased .", + "entities": [] + }, + { + "id": "2562", + "type": "gene", + "text": "Serum beta 2 - microglobulin levels ( beta - 2 - M ) were studied in 150 drug addicts , 50 of them asymptomatic carriers of anti HIV - 1 antibodies , 50 symptomatic carriers with persistent generalized lymphadenopathy ( P . G . L . ) and 50 serum negative patients who had been living in a closed community for at least 2 years .", + "entities": [ + "Serum beta 2 - microglobulin", + "beta - 2 - M", + "anti HIV - 1 antibodies" + ] + }, + { + "id": "2563", + "type": "gene", + "text": "Using 5 ' RACE and reverse transcription - PCR ( RT - PCR ) methodologies , we cloned these sequences from brain and placenta and found this material to be composed of alternatively spliced exons using a previously reported noncoding exon ( 1A ) and a novel 97 - bp noncoding exon ( 1B ) .", + "entities": [] + }, + { + "id": "2564", + "type": "gene", + "text": "Presentation of a horse cytochrome c peptide by multiple H - 2b class I major histocompatibility complex ( MHC ) molecules to C57BL / 6 - and bm1 - derived cytotoxic T lymphocytes : presence of a single MHC anchor residue may confer efficient peptide - specific CTL recognition .", + "entities": [ + "horse cytochrome c peptide", + "H - 2b class I major histocompatibility complex", + "MHC", + "MHC anchor residue" + ] + }, + { + "id": "2565", + "type": "gene", + "text": "XYL1 was isolated as a highly expressed fusion clone from a ' lacZ translational fusion library .", + "entities": [ + "XYL1", + "' lacZ" + ] + }, + { + "id": "2566", + "type": "gene", + "text": "Seven out of 34 patients died , giving a mortality rate of 21 % .", + "entities": [] + }, + { + "id": "2567", + "type": "gene", + "text": "Phosphorylation analyses indicated that inhibition of ERK - 1 / 2 decreased okadaic acid - elevated phosphorylation of JunD and FosB .", + "entities": [ + "ERK - 1 / 2", + "JunD", + "FosB" + ] + }, + { + "id": "2568", + "type": "gene", + "text": "HL - A antibodies in polytransfused patients", + "entities": [ + "HL - A antibodies" + ] + }, + { + "id": "2569", + "type": "gene", + "text": "These observations , together with the occurrence of putative 4 ' - phosphopantetheine - attachment sites and a putative thioesterase site , are discussed with reference to the reaction sequence leading to production of the ACV tripeptide .", + "entities": [ + "thioesterase site", + "ACV tripeptide" + ] + }, + { + "id": "2570", + "type": "gene", + "text": "RESULTS AND CONCLUSIONS : Brandt ' s double cuff - tubes ( G2 ) succeed in avoiding uncontrolled increase of cuff - pressure during anaesthesia with N2O .", + "entities": [] + }, + { + "id": "2571", + "type": "gene", + "text": "Two patients were treated with both regimens .", + "entities": [] + }, + { + "id": "2572", + "type": "gene", + "text": "The two contiguous IGF2 ( human insulin - like growth factor II ) and H19 genes are reciprocally imprinted in both human and mouse .", + "entities": [ + "IGF2", + "human insulin - like growth factor II", + "H19 genes" + ] + }, + { + "id": "2573", + "type": "gene", + "text": "The complete response ( CR ) rate was 34 % in the CODE with rhG - CSF group and 23 % in the CODE alone group ; the median survival was 59 and 32 weeks , respectively , in these groups ( P = 0 . 004 ) .", + "entities": [ + "rhG - CSF" + ] + }, + { + "id": "2574", + "type": "gene", + "text": "The matrix surrounding the clusters either showed a normal morphology or a homogeneous appearance , within which faint cross striations but no distinctly fibrillar outlines could be identified .", + "entities": [] + }, + { + "id": "2575", + "type": "gene", + "text": "Sixty - nine ( 44 % ) patients were administered 250 MBq ( 7 mCi ) 99Tcm - tetrofosmin at rest followed 4 h later by 750 MBq ( 21 mCi ) during stress ( the 1 day protocol ) , whereas 88 ( 56 % ) patients had rest and stress imaging studies on two separate days , receiving a 500 MBq ( 14 mCi ) dose of 99Tcm - tetrofosmin on each occasion ( the 2 day protocol ) .", + "entities": [] + }, + { + "id": "2576", + "type": "gene", + "text": "These results indicate a possible involvement of endogenous opioid peptides in the cardiac effects due to myocardial ischaemia and reperfusion , mediated by opiate receptors through opiate antagonism .", + "entities": [ + "opiate receptors" + ] + }, + { + "id": "2577", + "type": "gene", + "text": "The effects of taloximine and aminophylline on isolated human smooth muscle .", + "entities": [] + }, + { + "id": "2578", + "type": "gene", + "text": "Selenium status of thoroughbreds in the United Kingdom .", + "entities": [] + }, + { + "id": "2579", + "type": "gene", + "text": "Because GH - induced Akt activation was completely inhibited in both cells by the same concentration of LY294002 , these findings indicate that the wortmannin sensitivity of both the IRS - 1 - independent and - dependent GH - induced MAP kinase activation may reflect the activity of another wortmannin - sensitive target ( s ) in addition to PI3K in mediation of GH - induced MAP kinase activation in these cells .", + "entities": [ + "GH", + "Akt", + "IRS - 1", + "GH", + "MAP kinase", + "PI3K", + "GH", + "MAP kinase" + ] + }, + { + "id": "2580", + "type": "gene", + "text": "Plasma glucose , immunoreactive insulin ( IRI ) , C - peptide , glucagon , and GLP - 1 levels at each time point during OGTT were measured .", + "entities": [ + "immunoreactive insulin", + "IRI", + "C - peptide", + "glucagon", + "GLP - 1" + ] + }, + { + "id": "2581", + "type": "gene", + "text": "Functional magnetic resonance imaging ( fMRI ) has been increasingly used in studying human brain function given its non - invasive feature and good spatial resolution .", + "entities": [] + }, + { + "id": "2582", + "type": "gene", + "text": "An increase in bone mineral density at the spine , total hip , and total body has been reported with raloxifene but seems to be less than that seen with estrogen or alendronate therapy .", + "entities": [] + }, + { + "id": "2583", + "type": "gene", + "text": "Transcription of the vascular cell adhesion molecule 1 ( VCAM - 1 ) gene in endothelial cells is induced by lipopolysaccharide and the inflammatory cytokines interleukin - 1 beta and tumor necrosis factor alpha ( TNF - alpha ) .", + "entities": [ + "vascular cell adhesion molecule 1", + "VCAM - 1", + "cytokines interleukin - 1 beta", + "tumor necrosis factor alpha", + "TNF - alpha" + ] + }, + { + "id": "2584", + "type": "gene", + "text": "This in turn will further enhance the role of meta - analysis in helping clinicians and policy makers answer clinical questions .", + "entities": [] + }, + { + "id": "2585", + "type": "gene", + "text": "Muscle action potential and masticatory rhythm of anterior temporal and masseter muscles in children and adults", + "entities": [] + }, + { + "id": "2586", + "type": "gene", + "text": "The pharmacokinetic parameters which helped predict these toxicities included area under the curve and peak plasma level .", + "entities": [] + }, + { + "id": "2587", + "type": "gene", + "text": "These early structural processes are assumed to be subserved by the anterior parts of the left hemisphere , as event - related brain potentials show this area to be maximally activated when phrase structure violations are processed and as circumscribed lesions in this area lead to an impairment of the on - line structural assignment .", + "entities": [] + }, + { + "id": "2588", + "type": "gene", + "text": "We present evidence that DNA polymerase delta of Saccharomyces cerevisiae , an enzyme that is essential for viability and chromosomal replication , is also required for base excision repair of exogenous DNA methylation damage .", + "entities": [ + "DNA polymerase delta of Saccharomyces cerevisiae" + ] + }, + { + "id": "2589", + "type": "gene", + "text": "Northern blot analysis demonstrated that the STORP gene has a ubiquitous pattern of expression similar to that of the PML gene .", + "entities": [ + "STORP gene", + "PML gene" + ] + }, + { + "id": "2590", + "type": "gene", + "text": "Estrogen receptor - related receptor alpha 1 interacts with coactivator and constitutively activates the estrogen response elements of the human lactoferrin gene .", + "entities": [ + "Estrogen receptor - related receptor alpha 1", + "human lactoferrin gene" + ] + }, + { + "id": "2591", + "type": "gene", + "text": "Another long insertion in the cathepsin X amino acid sequence forms a beta - hairpin pointing away from the active site .", + "entities": [ + "cathepsin X amino acid sequence" + ] + }, + { + "id": "2592", + "type": "gene", + "text": "Structure determination of an adsorbate - induced multilayer reconstruction : ( 1 x 2 ) - H / Ni ( 110 ) .", + "entities": [] + }, + { + "id": "2593", + "type": "gene", + "text": "The intron RNA consists of 2492 nucleotides which can be folded into a secondary structure with all the expected sequence motifs of subgroup - IIA1 introns ( Michel et al .", + "entities": [] + }, + { + "id": "2594", + "type": "gene", + "text": "Cleidocranial dysostosis", + "entities": [] + }, + { + "id": "2595", + "type": "gene", + "text": "Rabbits developed profound hypocalcemia , with levels falling from 15 . 5 + / - 0 . 2 to 7 . 6 + / - 0 . 4 mg / dl under the influence of TSST - 1 .", + "entities": [ + "TSST - 1" + ] + }, + { + "id": "2596", + "type": "gene", + "text": "Generally , a correlation was observed between highest concentrations of CSF immunoglobulins and degree of meningeal inflammatory response , even if this was a component of other neurological diseases .", + "entities": [ + "CSF immunoglobulins" + ] + }, + { + "id": "2597", + "type": "gene", + "text": "Citrate synthase activity was increased in the medial head ( 81 % , P < 0 . 001 ) and the red long head ( 88 % , P < 0 . 001 ) of the triceps brachii muscle in R rats but not in the white long head ( 25 % , P = 0 . 06 ) .", + "entities": [ + "Citrate synthase" + ] + }, + { + "id": "2598", + "type": "gene", + "text": "We find that BCL - 6 POZ domain mutations that disrupt the interaction with N - CoR and SMRT no longer repress transcription .", + "entities": [ + "BCL - 6", + "N - CoR", + "SMRT" + ] + }, + { + "id": "2599", + "type": "gene", + "text": "A mutant in the AAV terminal resolution site ( trs ) was defective for DNA replication in the in vitro assay .", + "entities": [] + }, + { + "id": "2600", + "type": "gene", + "text": "This slow progression through the early G1 - phase resulted in decreased phosphorylation of the RB protein and subsequent delay into the S phase transition .", + "entities": [ + "RB protein" + ] + }, + { + "id": "2601", + "type": "gene", + "text": "At this stage , the eventual high mortality of acute ischemia is established whatever the urgency of the operation or the skill with which it is performed .", + "entities": [] + }, + { + "id": "2602", + "type": "gene", + "text": "We report an example of an MDV - transformed T - lymphoblastoid cell line ( T9 ) expressing high levels of a truncated C - MYB protein as a result of RAV integration within one c - myb allele .", + "entities": [ + "truncated C - MYB protein", + "c - myb allele" + ] + }, + { + "id": "2603", + "type": "gene", + "text": "Reovirus mRNAs are efficiently translated within host cells despite the absence of 3 ' polyadenylated tails .", + "entities": [] + }, + { + "id": "2604", + "type": "gene", + "text": "Survival after development of symptomatic infection ( P - 2 ) did not differ by transmission mode .", + "entities": [] + }, + { + "id": "2605", + "type": "gene", + "text": "Pharmacological desympathization leads to the development of hyper - reactivity of the true pacemakers to noradrenaline and dopamine and triggers off changes in the regulation of the electric activity of these cells by catecholamines .", + "entities": [] + }, + { + "id": "2606", + "type": "gene", + "text": "Sequencing of the TP53 transcripts from exons 2 to 10 , however , did not reveal mutations of the remaining allele in any of these tumors .", + "entities": [ + "TP53 transcripts" + ] + }, + { + "id": "2607", + "type": "gene", + "text": "Nineteen patients with non - visualized gallbladder with OCG subsequently had Tc - 99m - PyG cholescintigraphy performed .", + "entities": [] + }, + { + "id": "2608", + "type": "gene", + "text": "Genetic and molecular data indicate that wild - type Pan and CiD compete for binding to Arm , leading to a compromised transduction of the Wg signal in heterozygous ciD / + animals and to a dramatic enhancement of the gain - of - function activity of CiD in homozygous mutants .", + "entities": [ + "wild - type Pan", + "CiD", + "Arm", + "Wg", + "ciD / +", + "CiD" + ] + }, + { + "id": "2609", + "type": "gene", + "text": "The open reading frames of rbsD , rbsA , and rbsC encode proteins of 139 , 501 , and 321 amino acid residues , respectively .", + "entities": [ + "rbsD", + "rbsA", + "rbsC" + ] + }, + { + "id": "2610", + "type": "gene", + "text": "The E6 / E7 promoter of all genital human papillomaviruses is responsible for expression of the viral transforming genes .", + "entities": [ + "E6", + "E7" + ] + }, + { + "id": "2611", + "type": "gene", + "text": "Children with ADD showed an attenuated frontal CNV - 1 amplitude and a trend towards increased CNV - 1 and CNV - 2 occipital amplitudes .", + "entities": [] + }, + { + "id": "2612", + "type": "gene", + "text": "The transcription factor E2F plays an important role in G ( 1 ) to S phase transition in the higher eukaryotic cell cycle .", + "entities": [ + "E2F" + ] + }, + { + "id": "2613", + "type": "gene", + "text": "Fortunately DDT - , HCH - and HCB - levels decreased in breast milk during the last years .", + "entities": [] + }, + { + "id": "2614", + "type": "gene", + "text": "Aneurysmectomy and the performance of CABG were not significantly associated with postoperative ECG changes , but more bypass grafts per patient grafted appeared in the group with postoperative ECG changes , suggesting that coronary artery disease may be more severe in that group .", + "entities": [] + }, + { + "id": "2615", + "type": "gene", + "text": "One complex appears to be ubiquitous but enriched in lymphoid cells and represents the binding of a potentially novel factor with an apparent molecular mass of approximately 50 kDa .", + "entities": [] + }, + { + "id": "2616", + "type": "gene", + "text": "We linked a 4 . 1 - kilobase pair HindIII DNA fragment from the region upstream of the human AP endonuclease gene ( APE ) to the chloramphenicol acetyltransferase ( CAT ) gene .", + "entities": [ + "HindIII DNA fragment", + "human AP endonuclease gene", + "APE", + "chloramphenicol acetyltransferase", + "CAT" + ] + }, + { + "id": "2617", + "type": "gene", + "text": "Transient hyperammonaemia in an adult German shepherd dog .", + "entities": [] + }, + { + "id": "2618", + "type": "gene", + "text": "Our data suggest that , at least at high temperature , a critical minimal level of Ypt protein prenylation is required for maintaining vesicle polarization .", + "entities": [ + "Ypt protein" + ] + }, + { + "id": "2619", + "type": "gene", + "text": "Stems contain distinctly less P protein mRNA and the relative level in roots is very low but still clearly detectable .", + "entities": [ + "P protein mRNA" + ] + }, + { + "id": "2620", + "type": "gene", + "text": "Interleukin - 6 ( IL - 6 ) is a pleiotropic cytokine , which is involved in inflammatory and immune responses , acute phase reactions , and hematopoiesis .", + "entities": [ + "Interleukin - 6", + "IL - 6" + ] + }, + { + "id": "2621", + "type": "gene", + "text": "Activation of alpha 4 beta 1 with TS2 / 16 inhibited the cytoplasmic protrusions and cell migration but did not affect the pattern of phosphorylation .", + "entities": [ + "alpha 4 beta 1", + "TS2 / 16" + ] + }, + { + "id": "2622", + "type": "gene", + "text": "Further , intracerebroventricular injections of KA resulted in the substantial loss of pyramidal cells in the whole CA3 field of the hippocampus .", + "entities": [] + }, + { + "id": "2623", + "type": "gene", + "text": "Despite the small number of patients , on the basis of this report , we can confirm that 1 . 5 MU / day of alpha - IFN is an adequate treatment for patients with hairy cell leukemia .", + "entities": [ + "alpha - IFN" + ] + }, + { + "id": "2624", + "type": "gene", + "text": "But the application solutions of instrument disinfectants should not be used longer than one day .", + "entities": [] + }, + { + "id": "2625", + "type": "gene", + "text": "The SCMV SNE sites contain potential overlapping core recognition binding motifs for SRF , Rel / NFkappaB , ETS , and YY1 class transcription factors but fail to respond to either serum or tumor necrosis factor alpha .", + "entities": [ + "SCMV SNE sites", + "SRF", + "Rel", + "NFkappaB", + "ETS", + "YY1 class transcription factors", + "tumor necrosis factor alpha" + ] + }, + { + "id": "2626", + "type": "gene", + "text": "Stress effects on affiliation preferences among subjects possessing the type A coronary - prone behavior pattern .", + "entities": [] + }, + { + "id": "2627", + "type": "gene", + "text": "The decay curves of chlorophyll fluorescence showed a superposition of three exponentially decaying components with time constants of T1 = 100 - 200 ps , T2 = 300 - 500 ps and T3 = 2 . 0 - 3 . 5 ns .", + "entities": [] + }, + { + "id": "2628", + "type": "gene", + "text": "The availability of sequence from multiple species has permitted us to determine that the UBE site has close similarity to motifs that bind members of the NF - 1 family of transcription factors .", + "entities": [ + "NF - 1 family of transcription factors" + ] + }, + { + "id": "2629", + "type": "gene", + "text": "The chromosomal localization on distal chromosome 7 places it in a cluster of imprinted genes , flanked by the previously described Tapa1 and Kcnq1 genes .", + "entities": [ + "Tapa1", + "Kcnq1 genes" + ] + }, + { + "id": "2630", + "type": "gene", + "text": "These results suggest that HAC1 may also be one of the meiotic genes .", + "entities": [ + "HAC1" + ] + }, + { + "id": "2631", + "type": "gene", + "text": "In order to gain deeper insight into the role of the amino - terminal domain of the p24 ( CA ) protein during viral replication , eight highly conserved proline residues known to promote turns and to terminate alpha - helices within the p24 tertiary structure were replaced by a leucine residue ( P - position - L ) .", + "entities": [ + "p24", + "CA", + "p24" + ] + }, + { + "id": "2632", + "type": "gene", + "text": "Structural organization and developmental expression pattern of the mouse WD - repeat gene DMR - N9 immediately upstream of the myotonic dystrophy locus .", + "entities": [ + "mouse WD - repeat gene DMR - N9", + "myotonic dystrophy locus" + ] + }, + { + "id": "2633", + "type": "gene", + "text": "Furthermore it was suggested that FK506 plasma levels were concerned with the appearance of side effect .", + "entities": [] + }, + { + "id": "2634", + "type": "gene", + "text": "During exercise , the Pes - Ves relation was shifted toward the left and the slope [ end - systolic elastance ( Ees ) ] increased from 7 . 7 + / - 2 . 8 to 12 . 7 + / - 4 . 2 ( SD ) mmHg / ml ( P < 0 . 05 ) .", + "entities": [] + }, + { + "id": "2635", + "type": "gene", + "text": "The IgG subclass profile of untreated coeliac disease was found to be the same as in healthy controls ( IgG1 approximately IgG2 > IgG3 > IgG4 ) , with only the magnitude of the individual subclass responses being increased in coeliac patients .", + "entities": [ + "IgG", + "IgG1", + "IgG2", + "IgG3", + "IgG4" + ] + }, + { + "id": "2636", + "type": "gene", + "text": "Furthermore , synergistic activation of ERK2 occurred in the absence of changes in intracellular Ca2 + , and was not blocked by inhibition of protein kinase C activity and represents a separate pathway by which CD19 regulates B cell function .", + "entities": [ + "ERK2", + "protein kinase C", + "CD19" + ] + }, + { + "id": "2637", + "type": "gene", + "text": "Substituting a Ser for Gly69 or a Glu for Lys 71 in the conserved TGEK tetrapeptide in finger II of TFIIIA resulted in the loss of DNA binding .", + "entities": [ + "TGEK tetrapeptide", + "TFIIIA" + ] + }, + { + "id": "2638", + "type": "gene", + "text": "Sternocleidomastoid , neck or facial muscles wasting were also found in three cases .", + "entities": [] + }, + { + "id": "2639", + "type": "gene", + "text": "Harel , E . M .", + "entities": [] + }, + { + "id": "2640", + "type": "gene", + "text": "The first 85 nt upstream of the transcription initiation site of the mouse desmin gene , which contain an E box ( E1 ) , the binding site of the helix - loop - helix myogenic regulators , are sufficient to confer low level muscle - specific expression .", + "entities": [ + "mouse desmin gene", + "helix - loop - helix myogenic regulators" + ] + }, + { + "id": "2641", + "type": "gene", + "text": "Thus , unlike other proteins reported to inhibit SRF activity , the repressor activity associated with the GC - rich element does not appear to function through direct inhibition of SRF binding .", + "entities": [ + "SRF", + "SRF" + ] + }, + { + "id": "2642", + "type": "gene", + "text": "Using backcross analysis , both exons 1 and 4 mapped to a proximal region of murine Chromosome 4 indistinguishable from the vacillans gene .", + "entities": [ + "vacillans gene" + ] + }, + { + "id": "2643", + "type": "gene", + "text": "Large and small medullary lesions inhibited the occurrence of target fibres in the tenotomized muscles , the smallest one being neurolysis of the dorsal roots .", + "entities": [] + }, + { + "id": "2644", + "type": "gene", + "text": "Pups placed into the novel environment with their mothers exhibited an intermediate level of DA turnover .", + "entities": [] + }, + { + "id": "2645", + "type": "gene", + "text": "Resources for helping patients to quit smoking .", + "entities": [] + }, + { + "id": "2646", + "type": "gene", + "text": "The results show that the structure of the decorin gene promoter is different from that of any other proteoglycan promoter characterized so far and indicate that the pur / pyr segment plays a role in the regulation of gene transcription .", + "entities": [ + "decorin gene promoter" + ] + }, + { + "id": "2647", + "type": "gene", + "text": "In this study , we have cloned the 5 ' - flanking region of the human nidogen gene .", + "entities": [ + "human nidogen gene" + ] + }, + { + "id": "2648", + "type": "gene", + "text": "None had a past history of opportunistic infections ; neither did any have lymphopenia .", + "entities": [] + }, + { + "id": "2649", + "type": "gene", + "text": "We examined the effects of long - term perfusion with pyridoxalated hemoglobin polyoxyethylene conjugate ( PHP ) solution on cardiac function of isolated rat hearts .", + "entities": [ + "hemoglobin" + ] + }, + { + "id": "2650", + "type": "gene", + "text": "Taken together , our data suggest that Rat7p / Nup159p is anchored within the NPC through its coiled - coil region and adjacent sequences .", + "entities": [ + "Rat7p", + "Nup159p" + ] + }, + { + "id": "2651", + "type": "gene", + "text": "Acoustic transmission spectra in the Penrose lattice .", + "entities": [] + }, + { + "id": "2652", + "type": "gene", + "text": "In Cd - spiked OECD soil , internal Cd levels were linearly related to external Cd concentrations , whereas the springtails maintained fixed internal levels of Cu and Zn regardless of spiked concentrations .", + "entities": [] + }, + { + "id": "2653", + "type": "gene", + "text": "Significantly , pPKR is capable of specifically phosphorylating Ser51 in a synthetic eIF - 2alpha peptide , a key characteristic of the eIF - 2alpha kinase family .", + "entities": [ + "pPKR", + "synthetic eIF - 2alpha peptide", + "eIF - 2alpha kinase family" + ] + }, + { + "id": "2654", + "type": "gene", + "text": "Many eukaryotic cell surface proteins are anchored in the lipid bilayer through glycosylphosphatidylinositol ( GPI ) .", + "entities": [] + }, + { + "id": "2655", + "type": "gene", + "text": "In general , the values obtained by the two methods were in agreement for each species of epidermal growth factor and followed the order : wild type greater than Glu24 - - - - Gly greater than Asp27 - - - - Gly much greater than Pro7 - - - - Thr greater than Tyr29 - - - - Gly greater than Leu47 - - - - His .", + "entities": [ + "epidermal growth factor" + ] + }, + { + "id": "2656", + "type": "gene", + "text": "Structure , promoter analysis and chromosomal assignment of the human APEX gene .", + "entities": [ + "human APEX gene" + ] + }, + { + "id": "2657", + "type": "gene", + "text": "Compensative justice and moral investment among Japanese , Chinese , and Koreans .", + "entities": [] + }, + { + "id": "2658", + "type": "gene", + "text": "RESULTS : Among women , the age - related decline in BMD at all non - spine skeletal sites was significantly different from zero , with the largest decline seen at the femoral neck ( - . 0038 g / cm2 / y , p < . 001 ) and the smallest at the trochanter of the hip ( - . 0023 g / cm2 / y , p = . 03 ) .", + "entities": [] + }, + { + "id": "2659", + "type": "gene", + "text": "UV cross - linking experiments show that TEP has an apparent molecular mass of approximately 65 kDa .", + "entities": [ + "TEP" + ] + }, + { + "id": "2660", + "type": "gene", + "text": "Like other members of this family , the AP - 4 HLH motif and the adjacent basic domain are necessary and sufficient to confer site - specific DNA binding .", + "entities": [ + "AP - 4" + ] + }, + { + "id": "2661", + "type": "gene", + "text": "The average backscatter coefficient was six time larger in regions of infarct studied 8 - - 10 weeks after occlusion than that in regions of infarct studied 5 - - 6 weeks after occlusion .", + "entities": [] + }, + { + "id": "2662", + "type": "gene", + "text": "Immunocytochemical analysis demonstrated the presence of DREF polypeptide in nuclei after the eighth nuclear division cycle , suggesting that nuclear accumulation of DREF is important for the coordinate zygotic expression of DNA replication - related genes carrying DRE sequences .", + "entities": [ + "DREF polypeptide", + "DREF" + ] + }, + { + "id": "2663", + "type": "gene", + "text": "In contrast the human and mouse BCNT proteins contain one repeat unit and lack the RTE - 1 - derived portion .", + "entities": [ + "mouse BCNT proteins", + "RTE - 1" + ] + }, + { + "id": "2664", + "type": "gene", + "text": "Structural analysis and characterization of tissue and hormonal responsive expression of the avian bone sialoprotein ( BSP ) gene .", + "entities": [ + "avian bone sialoprotein", + "BSP" + ] + }, + { + "id": "2665", + "type": "gene", + "text": "US - Doppler has recently gained attention as a noninvasive method for the functional evaluation of arteriovenous fistulas ( FAV ) .", + "entities": [] + }, + { + "id": "2666", + "type": "gene", + "text": "A single amino acid change in the CPY vacuolar sorting signal prevents this interaction .", + "entities": [ + "CPY vacuolar sorting signal" + ] + }, + { + "id": "2667", + "type": "gene", + "text": "The Epstein - Barr virus transactivator Zta triggers lytic gene expression and is essential for replication of the lytic origin , oriLyt .", + "entities": [ + "Epstein - Barr virus transactivator Zta" + ] + }, + { + "id": "2668", + "type": "gene", + "text": "RESULTS : Cholinergic nerves are mainly involved in the regulation of enteric nerve responses to EFS in the normal IAS .", + "entities": [] + }, + { + "id": "2669", + "type": "gene", + "text": "These data show that heterologous virus RNAs ( BSMV ) can serve as primer donors for MStV mRNA capped RNA - primed transcription in doubly infected plants .", + "entities": [] + }, + { + "id": "2670", + "type": "gene", + "text": "Furthermore , p150 suppresses actin gelation , which is induced by smooth muscle alpha - actinin .", + "entities": [ + "p150", + "actin", + "smooth muscle alpha - actinin" + ] + }, + { + "id": "2671", + "type": "gene", + "text": "It is clear that subclinical and silent CD exist in a large subgroup of the celiac population .", + "entities": [] + }, + { + "id": "2672", + "type": "gene", + "text": "Proteins immunoprecipitated from lysates of control - and VEGF - stimulated BAEC with antisera to phospholipase C - gamma ( PLC - gamma ) were fractionated by SDS - polyacrylamide gel electrophoresis and transferred to Immobilon - P .", + "entities": [ + "VEGF", + "phospholipase C - gamma", + "PLC - gamma" + ] + }, + { + "id": "2673", + "type": "gene", + "text": "In Xenopus embryos , the engineered PDGF receptor protein induced the formation of mesoderm from animal - pole explants in an FK1012 - dependent manner .", + "entities": [ + "engineered PDGF receptor protein" + ] + }, + { + "id": "2674", + "type": "gene", + "text": "Southern blotting and single strand conformation polymorphism analyses did not show tumor - specific alterations of this gene in gliomas and RT - PCR studies showed expression in glioma cell lines , suggesting that ANOVA is not the chromosome 19q glioma tumor suppressor gene .", + "entities": [ + "ANOVA" + ] + }, + { + "id": "2675", + "type": "gene", + "text": "Incidence rate ranging between 122 / 100 , 000 / year and 190 / 100 , 000 / year were found ( minimum , estimated and raw datasets ) .", + "entities": [] + }, + { + "id": "2676", + "type": "gene", + "text": "Where UMDNJ is headed .", + "entities": [] + }, + { + "id": "2677", + "type": "gene", + "text": "UGA codon position affects the efficiency of selenocysteine incorporation into glutathione peroxidase - 1 .", + "entities": [ + "glutathione peroxidase - 1" + ] + }, + { + "id": "2678", + "type": "gene", + "text": "The IC50 values for rat and dog urinary bladder were 3 . 9 x 10 ( - 6 ) M and 3 . 8 x 10 ( - 6 ) M , respectively .", + "entities": [] + }, + { + "id": "2679", + "type": "gene", + "text": "Patients with Parkinson ' s disease showed a relatively high incidence to psychoses during drug treatment ( 51 . 47 % ) .", + "entities": [] + }, + { + "id": "2680", + "type": "gene", + "text": "The deduced amino acid sequence of destrin is 165 residues long and is very similar ( 71 % identical ) to that of cofilin , a widely distributed , pH - sensitive actin - modulating protein .", + "entities": [ + "destrin", + "cofilin", + "actin" + ] + }, + { + "id": "2681", + "type": "gene", + "text": "The ANB1 locus of Saccharomyces cerevisiae encodes the protein synthesis initiation factor eIF - 4D .", + "entities": [ + "ANB1 locus", + "protein synthesis initiation factor eIF - 4D" + ] + }, + { + "id": "2682", + "type": "gene", + "text": "Site - directed mutagenesis revealed that two clusters of basic amino acids within a conserved basic region and two amphipathic helices within the adjacent HLH domain are essential for sequence - specific DNA binding and hetero - oligomerization , respectively .", + "entities": [] + }, + { + "id": "2683", + "type": "gene", + "text": "Here , we show that the zinc finger protein Gis1 acts as a dosage - dependent suppressor of the rim15Delta defect in nutrient limitation - induced transcriptional derepression of SSA3 .", + "entities": [ + "zinc finger protein Gis1", + "rim15Delta", + "SSA3" + ] + }, + { + "id": "2684", + "type": "gene", + "text": "Patients with type III SOD may have visceral hyperalgesia ; a trial of antidepressants or a therapeutic trial with botulinum toxin injection into the ampulla should be considered prior to more invasive endoscopic therapy .", + "entities": [ + "botulinum toxin" + ] + }, + { + "id": "2685", + "type": "gene", + "text": "The present study was initiated to explore the potential of a hybrid biological reactor , combining trickling filter ( TF ) and activated sludge process ( ASP ) , to treat wastewater containing trichloroethylene ( TCE ) at ambient temperature at different hydraulic retention time ( HRT ) .", + "entities": [] + }, + { + "id": "2686", + "type": "gene", + "text": "A microsporidian , Nosema algerae Vavra and undeen , was found parasitizing larvae and adults of a laboratory colony of Culex pipiens L . originated from Gharbia Governorate .", + "entities": [] + }, + { + "id": "2687", + "type": "gene", + "text": "Using an ELISA , we found that surfactant protein A ( SP - A ) was markedly elevated in the pneumonia patients .", + "entities": [ + "surfactant protein A", + "SP - A" + ] + }, + { + "id": "2688", + "type": "gene", + "text": "These findings demonstrate that signature - tagged mutagenesis is a viable approach to identify bacterial genes associated with the ability to infect the urinary tract .", + "entities": [] + }, + { + "id": "2689", + "type": "gene", + "text": "CBT is discussed in comparison with the Wisconsin Card Sorting Test as a potential cognitive activation task for functional neuroimaging of the frontal lobes .", + "entities": [] + }, + { + "id": "2690", + "type": "gene", + "text": "Their mean IOP was 15 . 3 ( SD 3 . 7 ) mmHg prior to induction of anesthesia , 13 . 5 ( SD 3 . 5 ) mmHg after loss of eyelash reflex following injection of methohexitone , 16 . 1 ( SD 2 . 4 ) mmHg after cessation of muscle fasciculations induced by suxamethonium , 19 . 2 ( SD 5 . 6 ) mmHg after cessation of convulsion and 15 . 5 ( SD 4 . 4 ) mmHg following resumption of regular spontaneous respiration .", + "entities": [] + }, + { + "id": "2691", + "type": "gene", + "text": "Similarly , co - expression of a dominant - negative mutant of p38alpha , but not of ERK1 , ERK2 , JNK1 , or JNK2 , reduces basal and cadmium - induced pE1 - luc activity .", + "entities": [ + "p38alpha", + "ERK1", + "ERK2", + "JNK1", + "JNK2", + "pE1 - luc" + ] + }, + { + "id": "2692", + "type": "gene", + "text": "Diminished forearm arteriolar dilator capacity produced by mineralocorticoid - induced salt retention in man .", + "entities": [] + }, + { + "id": "2693", + "type": "gene", + "text": "A new instrument has been designed for freeze - fracturing of biological material in ultra high vacuum .", + "entities": [] + }, + { + "id": "2694", + "type": "gene", + "text": "Surprisingly , TFIIIC alpha has no homology to any of the yeast TFIIIC subunits already cloned , suggesting a significant degree of evolutionary divergence for RNA polymerase III factors .", + "entities": [ + "TFIIIC alpha", + "yeast TFIIIC subunits", + "RNA polymerase III factors" + ] + }, + { + "id": "2695", + "type": "gene", + "text": "We found that the expression of the protein was maximum in mitosis and minimum in G1 , which correlated with the expression of its messenger RNA .", + "entities": [] + }, + { + "id": "2696", + "type": "gene", + "text": "In addition to a previously characterized promoter ( P1 ) , we now show the existence of a second promoter for the human IL - 5Ralpha gene .", + "entities": [ + "human IL - 5Ralpha gene" + ] + }, + { + "id": "2697", + "type": "gene", + "text": "In synchronized HeLa cells , expression of luciferase activity was induced at the beginning of DNA synthesis and was dependent on the presence of an E2F - binding site in the H2A . 1 promoter .", + "entities": [ + "luciferase", + "E2F - binding site", + "H2A . 1 promoter" + ] + }, + { + "id": "2698", + "type": "gene", + "text": "The influence of a high ionic strength on the resolution was clearly shown .", + "entities": [] + }, + { + "id": "2699", + "type": "gene", + "text": "Analysis of the mouse STAP gene isolated from the genomic library revealed that the STAP gene spans a region of over 11 kb and comprises eight exons .", + "entities": [ + "mouse STAP gene", + "STAP gene" + ] + }, + { + "id": "2700", + "type": "gene", + "text": "Induction of the CINC promoter by IL - 17 in IEC - 6 cells was TNF receptor - associated factor - 6 ( TRAF6 ) , but not TRAF2 , dependent .", + "entities": [ + "CINC promoter", + "IL - 17", + "TNF receptor - associated factor - 6", + "TRAF6", + "TRAF2" + ] + }, + { + "id": "2701", + "type": "gene", + "text": "Furthermore , we showed that the IL - 6 / interferon gamma ( IFN gamma ) response element in the IRF - 1 promoter ( IR / IRF - 1 ) , which contains a Stat - binding site and an adjacent CRE - like site , also makes IL - 6 - induced binding complexes similar to JRE - IL6 - BCs .", + "entities": [ + "IL - 6", + "interferon gamma", + "IFN gamma", + "IRF - 1 promoter", + "IR", + "IRF - 1", + "Stat - binding site", + "IL - 6", + "IL6" + ] + }, + { + "id": "2702", + "type": "gene", + "text": "Tumor cell lines transduced at an MOI of 8 for 3 days led to > 90 % gene transfer efficiency .", + "entities": [] + }, + { + "id": "2703", + "type": "gene", + "text": "Isoelectric focusing of tryptic peptides generated from MHC - B phosphorylated with cdc2 kinase revealed one major phosphopeptide that was purified by reverse - phase high performance liquid chromatography and sequenced .", + "entities": [ + "MHC - B", + "cdc2 kinase" + ] + }, + { + "id": "2704", + "type": "gene", + "text": "Hemodynamics changes in man during flight", + "entities": [] + }, + { + "id": "2705", + "type": "gene", + "text": "Differential regulation of the alpha / beta interferon - stimulated Jak / Stat pathway by the SH2 domain - containing tyrosine phosphatase SHPTP1 .", + "entities": [ + "alpha / beta interferon", + "Jak", + "Stat", + "SH2", + "tyrosine phosphatase SHPTP1" + ] + }, + { + "id": "2706", + "type": "gene", + "text": "No positive family history was obtained .", + "entities": [] + }, + { + "id": "2707", + "type": "gene", + "text": "Hexsyn is the Goodyear Tire and Rubber Company tradename for a polyolefin rubber synthesized from 1 - hexene with 3 - 5 % methylhexadiene as the source of residual double bonds for vulcanization .", + "entities": [] + }, + { + "id": "2708", + "type": "gene", + "text": "These results demonstrate Ras - and Raf - independent ERK MAPK activation maintains cell viability following heat shock .", + "entities": [ + "Ras", + "Raf", + "ERK" + ] + }, + { + "id": "2709", + "type": "gene", + "text": "The plant protein maintains all the functional domains found in the other proteins , including nuclear localization signal , DNA - binding domain and helicase motifs , suggesting that it might also act as part of the RNA transcription apparatus , as well as nucleotide excision repair in plant cells .", + "entities": [ + "helicase motifs" + ] + }, + { + "id": "2710", + "type": "gene", + "text": "Gluzman , EMBO J .", + "entities": [] + }, + { + "id": "2711", + "type": "gene", + "text": "The receptor for hyaluronan mediated motility ( RHAMM ) gene expression is markedly elevated in fibrosarcomas exposed to transforming growth factor - beta1 ( TGF - beta1 ) .", + "entities": [ + "( RHAMM ) gene", + "transforming growth factor - beta1", + "TGF - beta1" + ] + }, + { + "id": "2712", + "type": "gene", + "text": "Chronic endotoxemia appears to be associated with an elevated pulmonary microvascular permeability and a tendency toward a hyperdynamic circulation but with an appreciable degree of refractoriness associated with regional hemodynamics and eicosanoid biosynthesis .", + "entities": [] + }, + { + "id": "2713", + "type": "gene", + "text": "ERV1 is involved in the cell - division cycle and the maintenance of mitochondrial genomes in Saccharomyces cerevisiae .", + "entities": [ + "ERV1" + ] + }, + { + "id": "2714", + "type": "gene", + "text": "Amplification and overexpression of the c - erbB - 2 gene in 21MT - 2 and 21MT - 1 human breast carcinoma cells results in progressively elevated levels of constitutively tyrosine - phosphorylated p185erbB - 2 and is associated with progressive insulin - like growth factor ( IGF ) and combined IGF / epidermal growth factor ( EGF ) independence in culture .", + "entities": [ + "c - erbB - 2 gene", + "tyrosine - phosphorylated p185erbB - 2", + "insulin - like growth factor", + "IGF", + "IGF", + "epidermal growth factor", + "EGF" + ] + }, + { + "id": "2715", + "type": "gene", + "text": "Steroids in germfree and conventional rats .", + "entities": [] + }, + { + "id": "2716", + "type": "gene", + "text": "The results suggest that the calcium antagonist , diltiazem , may modify the effects of isoflurane on myocardial function .", + "entities": [] + }, + { + "id": "2717", + "type": "gene", + "text": "C . elegans embryogenesis begins with a stereotyped sequence of asymmetric cell divisions that are largely responsible for establishing the nematode body plan .", + "entities": [] + }, + { + "id": "2718", + "type": "gene", + "text": "SV1 has a 33 - amino acid insert in the S1 transmembrane domain that does not alter S1 overall hydrophobicity , but makes the S0 - S1 linker longer .", + "entities": [ + "SV1" + ] + }, + { + "id": "2719", + "type": "gene", + "text": "CONCLUSIONS : In our patients and within the range of treatment variables studied , age , Karnofsky index , and graft - versus - host disease are the most important factors related with early mortality .", + "entities": [] + }, + { + "id": "2720", + "type": "gene", + "text": "An outbreak of hepatitis A among homosexual men in Amsterdam , 1991 - 1993 .", + "entities": [] + }, + { + "id": "2721", + "type": "gene", + "text": "Increases in the perfusate PCO2 but not in the perfusate H + were highly correlated with decreases in both myocardial contractility and oxygen consumption ( r2 = . 88 ) .", + "entities": [] + }, + { + "id": "2722", + "type": "gene", + "text": "Truncated forms of a novel yeast protein suppress the lethality of a G protein alpha subunit deficiency by interacting with the beta subunit .", + "entities": [ + "G protein alpha subunit" + ] + }, + { + "id": "2723", + "type": "gene", + "text": "However , the same U1A peptide , when conjugated to BSA , inhibits vertebrate PAP .", + "entities": [ + "U1A peptide", + "BSA", + "vertebrate PAP" + ] + }, + { + "id": "2724", + "type": "gene", + "text": "Direct proof that the heightened renal cellular apoptosis in PKD is not occurring through p53 was obtained by successive matings between SBM and p53 ( - / - ) mice .", + "entities": [ + "p53", + "p53" + ] + }, + { + "id": "2725", + "type": "gene", + "text": "The microphthalmia - TFE ( MiT ) subfamily of basic helix - loop - helix leucine zipper ( bHLH - ZIP ) transcription factors , including TFE3 , TFEB , TFEC , and Mitf , has been implicated in the regulation of tissue - specific gene expression in several cell lineages .", + "entities": [ + "microphthalmia - TFE", + "MiT", + "basic helix - loop - helix leucine zipper ( bHLH - ZIP ) transcription factors", + "TFE3", + "TFEB", + "TFEC", + "Mitf" + ] + }, + { + "id": "2726", + "type": "gene", + "text": "Human ESP1 / CRP2 protein has two LIM domains , and each shares 35 . 1 % and 77 or 79 % identical residues with human cysteine - rich protein ( CRP ) and rat CRIP , respectively .", + "entities": [ + "ESP1", + "CRP2", + "LIM", + "human cysteine - rich protein", + "CRP", + "rat CRIP" + ] + }, + { + "id": "2727", + "type": "gene", + "text": "The effect of maternal ingestion of the reduced energy sweetener erythritol was investigated in KBL : JW strain pregnant rabbits .", + "entities": [] + }, + { + "id": "2728", + "type": "gene", + "text": "Sudomoina , A .", + "entities": [] + }, + { + "id": "2729", + "type": "gene", + "text": "To evaluate whether the human gene is also a target of thyroid hormone we have searched for T3 - responsive elements in NRGN cloned genomic fragments spanning the whole gene .", + "entities": [ + "NRGN" + ] + }, + { + "id": "2730", + "type": "gene", + "text": "Such an hemoglobin solution was shown to exhibit a high affinity for oxygen and a low Bohr effect ( assessed from the delta log Po2 / delta pH ratio ) .", + "entities": [ + "hemoglobin" + ] + }, + { + "id": "2731", + "type": "gene", + "text": "Collectively , these results suggest that components of the protein kinase A signaling pathway are recruited by mIg to induce junB transcription .", + "entities": [ + "protein kinase A", + "mIg", + "junB" + ] + }, + { + "id": "2732", + "type": "gene", + "text": "An expression library was constructed by inserting 5 ' portion - enriched cDNAs from phytohemagglutinin - stimulated peripheral blood mononuclear cells into upstream of signal sequence - deleted CD4 cDNA in an Epstein - Barr virus shuttle vector .", + "entities": [ + "phytohemagglutinin", + "signal sequence - deleted CD4 cDNA" + ] + }, + { + "id": "2733", + "type": "gene", + "text": "When differentiated G0 - arrested leaf cells were induced to resume cell division by treatment with plant hormones , cycMs4 transcription was induced before the onset of DNA synthesis .", + "entities": [ + "cycMs4" + ] + }, + { + "id": "2734", + "type": "gene", + "text": "METHODS : A total of 15 pigs were randomised to ligation of left marginal arteries ( infarction group , n = 5 ) , to TMLR of the left lateral wall using a holmium : yttrium - aluminium garnet ( Ho : YAG ) laser ( laser group , n = 5 ) , and to both ( laser - infarction group , n = 5 ) .", + "entities": [] + }, + { + "id": "2735", + "type": "gene", + "text": "The potential impact of using a rapid diagnostic test ( Strep A OIA ) on detection and treatment of group A beta - hemolytic streptococcal ( GABHS ) pharyngitis in a large - volume pediatric and adolescent clinic was examined .", + "entities": [] + }, + { + "id": "2736", + "type": "gene", + "text": "One site , PAL , occurs within the 10 bp sequence GGGGAGGAGG .", + "entities": [ + "PAL" + ] + }, + { + "id": "2737", + "type": "gene", + "text": "In contrast , rats receiving U74500A ( 2 mg / kg i . v . infusion commencing 30 min prior to revascularisation ) exhibited enhanced GMBF throughout reperfusion [ PI 10 min : 3 . 26 ( 2 . 56 - 3 . 63 ) ; 120 min : 2 . 03 ( 1 . 73 - 2 . 25 ) ; 240 min : 2 . 13 ( 1 . 75 - 2 . 44 ) , p < 0 . 01 vs . controls and normals ] with complete muscle salvage [ GMV 100 % in all reperfused muscles , p < 0 . 01 vs . controls , not significant ( NS ) vs . normals and 6 h ischaemia ] . ( ABSTRACT TRUNCATED AT 250 WORDS )", + "entities": [] + }, + { + "id": "2738", + "type": "gene", + "text": "However , if the spatial resolution is not critical and interest is to compare a pathologic area with a contralateral VOI , then the acquisition of two single - voxel spectra may be preferred .", + "entities": [] + }, + { + "id": "2739", + "type": "gene", + "text": "This experimental design was used to determine the effect of displacement of the alpha 4 - 2 binding site on the repression of alpha 4 gene transcription by ICP4 .", + "entities": [ + "alpha 4 - 2 binding site", + "alpha 4 gene", + "ICP4" + ] + }, + { + "id": "2740", + "type": "gene", + "text": "Tests showed that an overall impression of the force applied could be obtained from a laboratory simulation , but that clearing cement and testing cement were not modelled by this method .", + "entities": [] + }, + { + "id": "2741", + "type": "gene", + "text": "The diagnosis of amyloidosis was determined from a labial salivary gland biopsy .", + "entities": [] + }, + { + "id": "2742", + "type": "gene", + "text": "Altogether , the results demonstrate that the two isoforms elicit similar responses in vivo despite differences in their regulation .", + "entities": [] + }, + { + "id": "2743", + "type": "gene", + "text": "A complementary DNA was isolated from Caenorhabditis elegans that encoded a polypeptide of 1438 amino acid residues , CeGAP , which contains a domain with sequence similarity to the COOH - terminal segment ( GTPase - activating protein region ) of Bcr and other known GTPase - activating proteins of the Rho subfamily .", + "entities": [ + "CeGAP", + "COOH - terminal segment ( GTPase - activating protein region )", + "Bcr", + "GTPase - activating proteins", + "Rho subfamily" + ] + }, + { + "id": "2744", + "type": "gene", + "text": "Low - selenium diet has a human unfavourable impact .", + "entities": [] + }, + { + "id": "2745", + "type": "gene", + "text": "Analysis of the binding of Lrp to a set of circularly permuted DNA fragments from this region indicates that Lrp induces DNA bending .", + "entities": [ + "Lrp", + "Lrp" + ] + }, + { + "id": "2746", + "type": "gene", + "text": "Additional studies with new and reprocessed regenerated cellulose dialyzers comparing 450 and 220 mL / min blood flow rates at 10 minutes showed no change in BTG .", + "entities": [] + }, + { + "id": "2747", + "type": "gene", + "text": "Patients with more than 250 PVC / 24 hours were selected for distribution of PVC and CI evaluation .", + "entities": [] + }, + { + "id": "2748", + "type": "gene", + "text": "The quantity of each population ( L . bulgaricus , S . thermophilus ) was then estimated in the pellet by PyMS , and the data were analysed by artificial neural networks ( ANNs ) .", + "entities": [] + }, + { + "id": "2749", + "type": "gene", + "text": "By analyzing the RanGAP activity of a series of recombinantly expressed rna1p mutant derivatives , we show that the highly acidic sequence in the C - terminal domain of both yeast proteins is indispensable for activating Ran - mediated GTP hydrolysis .", + "entities": [ + "RanGAP", + "rna1p mutant", + "Ran" + ] + }, + { + "id": "2750", + "type": "gene", + "text": "Organisms were recovered from the conjunctiva for several weeks , and persistent genital and gastrointestinal infection also resulted from the ocular infection in some cats .", + "entities": [] + }, + { + "id": "2751", + "type": "gene", + "text": "To establish a possible association between familial dysfibrinogenemia and thrombophilia , data on cases with both affections were collected in a study within the framework of the SSC Subcommittee on Fibrinogen of the International Society on Thrombosis and Haemostasis .", + "entities": [ + "Fibrinogen" + ] + }, + { + "id": "2752", + "type": "gene", + "text": "The sequences following the X . borealis oocyte and somatic 5S genes are identical in 12 of the first 14 residues and contain two or more T clusters , as does the corresponding region of X . laevis oocyte 5S DNA .", + "entities": [ + "5S genes", + "X . laevis oocyte 5S DNA" + ] + }, + { + "id": "2753", + "type": "gene", + "text": "Using this method , VLPs were obtained in quantities sufficient for further characterization .", + "entities": [] + }, + { + "id": "2754", + "type": "gene", + "text": "The stoichiometry of the complexes formed with the dodeca - satellite C strand suggests that , in DDP1 , the 15 consecutive KH domains are organized such that they define two nucleic acid binding surfaces .", + "entities": [ + "DDP1" + ] + }, + { + "id": "2755", + "type": "gene", + "text": "The relationships among four descriptors of lactate increase : lactate threshold ( LT ) ( the VO2 at which blood lactate concentration begins to increase above the resting level during an incremental exercise test ) , LT1 ( the VO2 at which blood lactate increases 1 mM above the resting level ) , LT2 ( the VO2 at which blood lactate concentration reaches a fixed value of 2 mM ) , onset of blood lactate accumulation ( OBLA ; the VO2 at which blood lactate reaches a concentration of 4 mM ) , were compared with aerobic capacity ( VO2max ) and 12 min running performance in 19 untrained female students .", + "entities": [] + }, + { + "id": "2756", + "type": "gene", + "text": "Human immunodeficiency virus type 1 Vpr is a virion - associated , regulatory protein that is required for efficient viral replication in monocytes / macrophages .", + "entities": [ + "Human immunodeficiency virus type 1 Vpr" + ] + }, + { + "id": "2757", + "type": "gene", + "text": "Zatebradine weakly depressed the ectopic ventricular rate but not the arrhythmic ratio of the ventricular arrhythmias induced by two - stage coronary ligation 24 h after the ligation in conscious dogs .", + "entities": [] + }, + { + "id": "2758", + "type": "gene", + "text": "The syncytial microvillous projections seemed to be more numerous and longer in CNF , otherwise the structure of the trophoblastic layer of the villi and the lining of the subtrophoblastic vessels were identical in CNF and controls .", + "entities": [] + }, + { + "id": "2759", + "type": "gene", + "text": "In addition to restoring checkpoint control , overexpression of sum1 + inhibits the normal cell cycle response to osmotic stress .", + "entities": [ + "sum1 +" + ] + }, + { + "id": "2760", + "type": "gene", + "text": "CONCLUSION : These results suggest that vibration - induced neural involvement can be considered neither pure digital neuropathy , nor definite CTS , as previously described .", + "entities": [] + }, + { + "id": "2761", + "type": "gene", + "text": "We show that several heme - responsive mechanisms combine to regulate DAN / TIR gene expression .", + "entities": [ + "DAN", + "TIR" + ] + }, + { + "id": "2762", + "type": "gene", + "text": "The results strengthen the conclusion that predominantly dynamic activity increases the G4 content of mature innervated fast muscles .", + "entities": [ + "G4" + ] + }, + { + "id": "2763", + "type": "gene", + "text": "Acetoin - dependent expression of the acoABCD operon could be restored in the E . coli acoK mutants by supplying a plasmid carrying an intact acoK , suggesting a transactivating function of the gene product .", + "entities": [ + "acoABCD operon", + "E . coli acoK mutants", + "acoK" + ] + }, + { + "id": "2764", + "type": "gene", + "text": "To further characterize the structure and evolutionary synthesis of the CMT1A - REP repeat , fluorescent in situ hybridization ( FISH ) analysis and heterologous PCR - based assays were carried out for a series of primates .", + "entities": [] + }, + { + "id": "2765", + "type": "gene", + "text": "Pregnant women at term had the lowest levels of antithrombin III .", + "entities": [ + "antithrombin III" + ] + }, + { + "id": "2766", + "type": "gene", + "text": "The results indicate that a more differentiated diagnosis of the molar relationship will allow for a more causally directed correction of Class II molar relationship .", + "entities": [] + }, + { + "id": "2767", + "type": "gene", + "text": "Thus , Pet111p could play dual roles in both membrane localization and regulation of Cox2p synthesis within mitochondria .", + "entities": [ + "Pet111p", + "Cox2p" + ] + }, + { + "id": "2768", + "type": "gene", + "text": "CONCLUSION : Chronic administration of misoprostol may have caused a negative natriuretic effect in cirrhotic patients with ascites .", + "entities": [] + }, + { + "id": "2769", + "type": "gene", + "text": "DNA sequence and functions of the actVI region of the actinorhodin biosynthetic gene cluster of Streptomyces coelicolor A3 ( 2 ) .", + "entities": [ + "actVI region", + "actinorhodin biosynthetic gene cluster of Streptomyces coelicolor A3 ( 2 )" + ] + }, + { + "id": "2770", + "type": "gene", + "text": "The event rate in patients with chronic Irr - rMFP or Un - nrMFP was markedly higher than it was in those with Rev - rMFP or Sta - nrMFP .", + "entities": [] + }, + { + "id": "2771", + "type": "gene", + "text": "The study disclosed generalized atrophy and diffuse symmetric white matter hypodensities .", + "entities": [] + }, + { + "id": "2772", + "type": "gene", + "text": "In addition to targeting partially assembled Ti alpha - beta CD3 gamma delta epsilon TCR complexes to the cell surface , CD3 zeta appears to be essential for interleukin - 2 production after TCR stimulation with antigen / major histocompatibility complex .", + "entities": [ + "TCR complexes", + "CD3 zeta", + "interleukin - 2", + "TCR", + "antigen / major histocompatibility complex" + ] + }, + { + "id": "2773", + "type": "gene", + "text": "DNase I footprint analysis identified a protected region from - 37 to - 53 .", + "entities": [ + "DNase I" + ] + }, + { + "id": "2774", + "type": "gene", + "text": "The endodontal treatment need has been forming a clinical order of magnitude .", + "entities": [] + }, + { + "id": "2775", + "type": "gene", + "text": "Essentially , 2 ' - O - methyl oligoribonucleotides ( 2 ' OMeRNA ) were delivered to the nuclei of primary mdx myoblasts in culture .", + "entities": [] + }, + { + "id": "2776", + "type": "gene", + "text": "Thus , the interaction of Tat with the components of this rel / AP1 cooperative complex seems to induce quantitative and qualitative alterations of this complex as activation progresses , resulting in a decrease of IL - 2 gene transcription .", + "entities": [ + "Tat", + "rel", + "AP1", + "IL - 2 gene" + ] + }, + { + "id": "2777", + "type": "gene", + "text": "One patient only had any test abnormalities .", + "entities": [] + }, + { + "id": "2778", + "type": "gene", + "text": "The authors report a case in which stereotactic irrigation of a brain cyst was temporally associated with respiratory distress .", + "entities": [] + }, + { + "id": "2779", + "type": "gene", + "text": "The data are compatible with the idea that YLL031c transfers the ethanolaminephosphate to the inner alpha1 - 2 - linked mannose , i . e . the group that links the GPI lipid anchor to proteins , whereas Mcd4p and Gpi7p transfer ethanolaminephosphate onto the alpha1 - 4 - and alpha1 - 6 - linked mannoses of the GPI anchor , respectively .", + "entities": [ + "YLL031c", + "Mcd4p", + "Gpi7p" + ] + }, + { + "id": "2780", + "type": "gene", + "text": "RAS2val19 , a dominant activated form of Saccharomyces cerevisiae Ras2 , stimulates both filamentous growth and expression of a transcriptional reporter FG ( TyA ) : : lacZ but does not induce the mating pathway reporter FUS1 : : lacZ .", + "entities": [ + "RAS2val19", + "Saccharomyces cerevisiae Ras2", + "FG", + "TyA", + "lacZ", + "mating pathway reporter FUS1", + "lacZ" + ] + }, + { + "id": "2781", + "type": "gene", + "text": "Furthermore , expression of the promoter in embryonic Drosophila melanogaster cells that lack MyoD1 and Sp1 is strictly dependent on all three sites remaining intact and on the presence of exogenously supplied Sp1 and MyoD1 .", + "entities": [ + "MyoD1", + "Sp1", + "Sp1", + "MyoD1" + ] + }, + { + "id": "2782", + "type": "gene", + "text": "Direct superoxide scavenging activity of nonsteroidal anti - inflammatory drugs : determination by electron spin resonance using the spin trap method .", + "entities": [] + }, + { + "id": "2783", + "type": "gene", + "text": "Direct approach to the study of soliton perturbations .", + "entities": [] + }, + { + "id": "2784", + "type": "gene", + "text": "The pretransplant regimen consisted of cyclophosphamide ( 120 mg / kg ) and total body irradiation .", + "entities": [] + }, + { + "id": "2785", + "type": "gene", + "text": "It may be time to reevaluate the dichotomy between AD and VaD .", + "entities": [] + }, + { + "id": "2786", + "type": "gene", + "text": "In vitro metabolism of progesterone by the human undescended testis .", + "entities": [] + }, + { + "id": "2787", + "type": "gene", + "text": "Subtraction hybridization identified melanoma differentiation associated gene - 7 ( mda - 7 ) , as a gene induced during these physiological changes in human melanoma cells .", + "entities": [ + "melanoma differentiation associated gene - 7", + "mda - 7" + ] + }, + { + "id": "2788", + "type": "gene", + "text": "The across - fiber pattern of the responses to hypotonic NaCl solutions correlated strongly to that elicited by distilled H2O . ( ABSTRACT TRUNCATED AT 400 WORDS )", + "entities": [] + }, + { + "id": "2789", + "type": "gene", + "text": "RESULTS : Looking at the question of its benefits , we were unable to find any methodologically sound studies that have shown efficacy for EMDR in eating disorders , or , indeed , any psychiatric disorder .", + "entities": [] + }, + { + "id": "2790", + "type": "gene", + "text": "U24 has two separate 12 nt long complementarities to a highly conserved tract of 28S rRNA .", + "entities": [ + "U24", + "28S rRNA" + ] + }, + { + "id": "2791", + "type": "gene", + "text": "E2 point mutants unable to inhibit cell growth did not repress cdc25A and cdc25B expression , nor did the cell cycle inhibitors hydroxyurea and mimosine .", + "entities": [ + "E2", + "cdc25A", + "cdc25B" + ] + }, + { + "id": "2792", + "type": "gene", + "text": "The results indicate that : 1 ) the initial response to tethering varies according to previous penning and handling experience , 2 ) although the circadian rhythm of cortisol was either altered or disrupted during estrus , such disruptions were not influenced by type of penning and 3 ) tether stalls may chronically increase cortisol concentrations in gilts .", + "entities": [] + }, + { + "id": "2793", + "type": "gene", + "text": "Fifty - one patients with primary refractory or relapsed malignant lymphoma ( 47 non - Hodgkin ' s lymphoma and four Hodgkin ' s disease ) were treated with a new chemotherapeutic regimen ( cisplatinum , methyl GAG , bleomocyin , methyl prednisolon ) .", + "entities": [] + }, + { + "id": "2794", + "type": "gene", + "text": "Activation was biphasic ; peaking at 5 - 10 min and 24 h after treatment .", + "entities": [] + }, + { + "id": "2795", + "type": "gene", + "text": "( LH P < 0 . 05 , LH / FSH P < 0 . 01 ) .", + "entities": [ + "LH", + "LH", + "FSH" + ] + }, + { + "id": "2796", + "type": "gene", + "text": "Because there is great need for iron in the EPO - stimulated erythroid progenitors , it is essential that serum ferritin and transferrin saturation levels should be maintained over 300 microg / liter and 30 % , respectively .", + "entities": [ + "EPO", + "serum ferritin", + "transferrin" + ] + }, + { + "id": "2797", + "type": "gene", + "text": "The criterion was reached after two sessions and generalization to a variety of pills and capsules occurred .", + "entities": [] + }, + { + "id": "2798", + "type": "gene", + "text": "The fracture groups were significantly older and had more years since menopause than the control groups .", + "entities": [] + }, + { + "id": "2799", + "type": "gene", + "text": "We detected no effect of deleting YCL024W , either alone or in combination with deletion of GIN4 .", + "entities": [ + "YCL024W", + "GIN4" + ] + }, + { + "id": "2800", + "type": "gene", + "text": "At each level of PaO2 we obtained simultaneous measures of arterial and venous blood gases , venous lactate concentration , and changes in the relative concentrations of inorganic phosphate , phosphocreatine , and ATP measured with 31P magnetic resonance spectroscopy .", + "entities": [] + }, + { + "id": "2801", + "type": "gene", + "text": "Newcastle disease antibody titre is dependent on serum calcium concentration .", + "entities": [ + "Newcastle disease antibody" + ] + }, + { + "id": "2802", + "type": "gene", + "text": "The alpha 7A form RNA contains an additional 113 nucleotides compared to the B form , and a common coding region in the A and B form RNAs is used in alternate reading frames .", + "entities": [] + }, + { + "id": "2803", + "type": "gene", + "text": "Pathological processes in the cervix uteri", + "entities": [] + }, + { + "id": "2804", + "type": "gene", + "text": "These results suggest that the M . jannaschii as well as related archaeal 20S proteasomes require a nucleotidase complex such as PAN to mediate the energy - dependent hydrolysis of folded - substrate proteins and that the N - terminal 73 amino acid residues of PAN are not absolutely required for this reaction .", + "entities": [ + "archaeal 20S proteasomes", + "PAN", + "PAN" + ] + }, + { + "id": "2805", + "type": "gene", + "text": "The implications for estimates of cortical magnification and possible differences in the specializations of foveal and peripheral vision are discussed .", + "entities": [] + }, + { + "id": "2806", + "type": "gene", + "text": "High - affinity binding sites for both GR and AP - 1 nucleoproteins were identified at adjacent elements within the nGRE .", + "entities": [ + "GR", + "AP - 1 nucleoproteins" + ] + }, + { + "id": "2807", + "type": "gene", + "text": "Cardiac output at anaerobic threshold ( COAT ) < or = 7 . 3 L / min was the best cutoff value for identifying multivessel coronary artery disease ( relative risk , 3 . 1 ) .", + "entities": [] + }, + { + "id": "2808", + "type": "gene", + "text": "A comparison of the duplicated Vkappa genes suggests positive selection on the complementarity - determining regions of the duplicated genes by point mutations .", + "entities": [ + "Vkappa genes" + ] + }, + { + "id": "2809", + "type": "gene", + "text": "These data may also aid in the localization of other disease loci mapped to this region , including the gene for tricho - dento - osseous syndrome and a murine locus for susceptibility to ozone - induced acute lung injury .", + "entities": [] + }, + { + "id": "2810", + "type": "gene", + "text": "Mutations in three loci ( SIC1 , SWI5 , and RIC3 ) were identified .", + "entities": [ + "SIC1", + "SWI5", + "RIC3" + ] + }, + { + "id": "2811", + "type": "gene", + "text": "The deduced bovine EFIA # 1 amino acid ( aa ) sequence is 98 % identical to rat EFIA and 100 % identical to human EFIA / DbpB / YB - 1 family member DNA - binding protein B ( DbpB ) .", + "entities": [ + "EFIA # 1", + "EFIA", + "EFIA", + "DbpB", + "YB - 1", + "DNA - binding protein B", + "DbpB" + ] + }, + { + "id": "2812", + "type": "gene", + "text": "PRH75 , a new nucleus - localized member of the DEAD - box protein family from higher plants .", + "entities": [ + "PRH75", + "DEAD - box protein family" + ] + }, + { + "id": "2813", + "type": "gene", + "text": "The imprinted expression of the endogenous gene can be recapitulated in mice by using a 14 - kb transgene encompassing 4 kb of 5 ' - flanking sequence , 8 kb of 3 ' - flanking sequence , which includes the two endoderm - specific enhancers , and an internally deleted structural gene .", + "entities": [] + }, + { + "id": "2814", + "type": "gene", + "text": "At this timepoint , many leucocytes in the ME and ET mucosa had incorporated BrdU ( between 15 and 25 % within the subsets ) .", + "entities": [] + }, + { + "id": "2815", + "type": "gene", + "text": "When expressed in and purified from Escherichia coli , both full - length Fpr3 and its isolated COOH - terminal domain exhibit readily detectable PPIase activity .", + "entities": [ + "full - length Fpr3", + "PPIase" + ] + }, + { + "id": "2816", + "type": "gene", + "text": "Cluster formation of E - cadherin on the cell surface is believed to be of major importance for cell - cell adhesion .", + "entities": [ + "E - cadherin" + ] + }, + { + "id": "2817", + "type": "gene", + "text": "We concluded that Ga - fbg scintigraphy is a very simple method and sufficiently useful for detecting active left ventricular thrombi and for monitoring the effect of anticoagulant therapy .", + "entities": [] + }, + { + "id": "2818", + "type": "gene", + "text": "Northern blot analysis of RNAs from a number of mouse tissues reveals that Atp6i is expressed predominantly in osteoclasts , and this predominant expression was confirmed by reverse - transcription polymerase chain reaction ( RT - PCR ) assay and immunohistochemical analysis .", + "entities": [ + "Atp6i" + ] + }, + { + "id": "2819", + "type": "gene", + "text": "Evidence that opiate addiction is in part an immune response .", + "entities": [] + }, + { + "id": "2820", + "type": "gene", + "text": "Changes following periodontal surgery .", + "entities": [] + }, + { + "id": "2821", + "type": "gene", + "text": "The conserved ninth C - terminal heptad in thyroid hormone and retinoic acid receptors mediates diverse responses by affecting heterodimer but not homodimer formation .", + "entities": [ + "retinoic acid receptors" + ] + }, + { + "id": "2822", + "type": "gene", + "text": "Lymphocytes from all 3 species yielded maximum responses with a 48 - hour prelabel and 12 - to - 16 hour postlabel incubation period at 41 C and 1 : 20 blood dilution .", + "entities": [] + }, + { + "id": "2823", + "type": "gene", + "text": "The improved CSF outflow conductance may increase the intracranial compliance and thereby dampen a pathological ICP waveform .", + "entities": [] + }, + { + "id": "2824", + "type": "gene", + "text": "This finding represents both a potentially important mechanism by which HPV gene expression can be regulated and an interesting model for the study of transcriptional cooperativity .", + "entities": [] + }, + { + "id": "2825", + "type": "gene", + "text": "Analysis of 1 Mb of published sequence from the region of conserved synteny on human chromosome 5q31 - q33 identified 45 gene candidates , including 35 expressed genes in the human IL - 4 cytokine gene cluster .", + "entities": [ + "human IL - 4 cytokine gene cluster" + ] + }, + { + "id": "2826", + "type": "gene", + "text": "However , one CAK - phosphorylated phosphopeptide comigrates with a Cdc2 - phosphorylated phosphopeptide previously shown to be mitosis - specific , suggesting that , in vitro , CAK is able to phosphorylate at least one site that is also phosphorylated in vivo .", + "entities": [ + "CAK", + "Cdc2", + "CAK" + ] + }, + { + "id": "2827", + "type": "gene", + "text": "The topology and chain folding of the beta subunits in the artifactual beta 60 capsid are similar to the native alpha 3 beta 60 enzyme .", + "entities": [ + "native alpha 3 beta 60 enzyme" + ] + }, + { + "id": "2828", + "type": "gene", + "text": "Among 100 cases of post - transfusion hepatitis , 10 are due to the hepatitis B virus ( despite systematic search for HBs Ag ) , 89 are due to one of the non - A non - B viruses ( not detectable by specific serological tests ) and 1 to several viruses , specially CMV .", + "entities": [ + "HBs Ag" + ] + }, + { + "id": "2829", + "type": "gene", + "text": "Electronic structure of a buried NiSi2 or CoSi2 layer in bulk Si .", + "entities": [] + }, + { + "id": "2830", + "type": "gene", + "text": "The retrovesical hydatid cyst is a very rare site .", + "entities": [] + }, + { + "id": "2831", + "type": "gene", + "text": "Thin melanomas can metastasize and be lethal .", + "entities": [] + }, + { + "id": "2832", + "type": "gene", + "text": "PULSE is used to set such NMR spectroscopic parameters as the delay and duration of rf transmit and receive gates , rf phase , sampling times , and such imaging parameters as rf pulse shape and gradient waveforms .", + "entities": [] + }, + { + "id": "2833", + "type": "gene", + "text": "Abstracts .", + "entities": [] + }, + { + "id": "2834", + "type": "gene", + "text": "The MCAD nuclear receptor response element 1 ( NRRE - 1 ) interacts in vitro with ERR alpha expressed in COS - 7 cells .", + "entities": [ + "MCAD nuclear receptor response element 1", + "NRRE - 1", + "ERR alpha" + ] + }, + { + "id": "2835", + "type": "gene", + "text": "Four forms of salmonellosis were recognised in feedlots and during transport by sea : septicaemic , and acute , subacute and chronic enteric .", + "entities": [] + }, + { + "id": "2836", + "type": "gene", + "text": "Single - photon emission computed tomography ( SPECT ) with 99mTc - hexamethylpropyleneamine oxime ( HMPAO ) was used to investigate changes in cerebral blood flow in seven patients with cortical visual impairment .", + "entities": [] + }, + { + "id": "2837", + "type": "gene", + "text": "Trials of sevine activity against mosquito larvae", + "entities": [] + }, + { + "id": "2838", + "type": "gene", + "text": "These results are consistent with the well established polarity of RXR heterodimer binding to bipartite hormone response elements , with the VDR recognizing the 3 ' - half - element .", + "entities": [ + "RXR", + "VDR" + ] + }, + { + "id": "2839", + "type": "gene", + "text": "The actuarial local control rates at 10 years for the three treatment groups were as follows : subtotal excision alone , 18 % ; subtotal excision plus postoperative radiation therapy , 82 % ; and total excision alone , 77 % .", + "entities": [] + }, + { + "id": "2840", + "type": "gene", + "text": "Drug and nutrient interactions .", + "entities": [] + }, + { + "id": "2841", + "type": "gene", + "text": "Similarly , we examined whether the ELK1 , SAP1a , FLI1 , EWS - FLI1 , ETS1 , ETS2 , PEA3 and PU . 1 proteins can form ternary complexes with SRF on the Egr1 SREI and II .", + "entities": [ + "ELK1", + "SAP1a", + "FLI1", + "EWS", + "FLI1", + "ETS1", + "ETS2", + "PEA3", + "PU . 1 proteins", + "SRF", + "SREI and II" + ] + }, + { + "id": "2842", + "type": "gene", + "text": "The Tullio phenomenon , fistula test , and Hennebert ' s sign : clinical significance .", + "entities": [] + }, + { + "id": "2843", + "type": "gene", + "text": "To study the regulation of mdr2 expression , the promoter of the mdr2 gene has been isolated from a murine vinblastine - resistant cell line , J7 . V2 - 1 , and characterized .", + "entities": [ + "mdr2", + "mdr2 gene" + ] + }, + { + "id": "2844", + "type": "gene", + "text": "Histopathologic observations showed that both somatostatin and triamcinolone acetonide reduced the inflammatory signs in the joint structures , although triamcinolone acetonide appeared to be more effective .", + "entities": [ + "somatostatin" + ] + }, + { + "id": "2845", + "type": "gene", + "text": "Prenatal exposure to the fungicide dinocap causes behavioral torticollis , ballooning and cleft palate in mice , but not rats or hamsters .", + "entities": [] + }, + { + "id": "2846", + "type": "gene", + "text": "The cytogenetic expression of the folate sensitive fragile site , FRAXE , is due to the expansion of a GCC repeat in proximal Xq28 of the human X chromosome and is associated with a mild form of mental handicap .", + "entities": [ + "FRAXE" + ] + }, + { + "id": "2847", + "type": "gene", + "text": "Laboratory evaluation was normal , and neuroimaging failed to confirm obstruction of venous or lymphatic drainage .", + "entities": [] + }, + { + "id": "2848", + "type": "gene", + "text": "The spacing of the essential N - terminal domain ( END ) relative to the HFD can be changed significantly without an apparent effect on Cse4p function .", + "entities": [ + "HFD", + "Cse4p" + ] + }, + { + "id": "2849", + "type": "gene", + "text": "They were called PACE4 and PC4 .", + "entities": [ + "PACE4", + "PC4" + ] + }, + { + "id": "2850", + "type": "gene", + "text": "Histopathological examination revealed dose - related proliferation of type II pneumocytes in dams and proliferation of interstitial cells and delayed septal / capillary development in neonates . ( ABSTRACT TRUNCATED AT 250 WORDS )", + "entities": [] + }, + { + "id": "2851", + "type": "gene", + "text": "Antibodies directed against the SNM1 protein immunoprecipitated RNase MRP RNA from whole - cell extracts without precipitating the structurally and functionally related RNase P RNA .", + "entities": [ + "SNM1 protein", + "RNase MRP RNA", + "RNase P RNA" + ] + }, + { + "id": "2852", + "type": "gene", + "text": "Calcium and phosphorus metabolism in chronic uremia .", + "entities": [] + }, + { + "id": "2853", + "type": "gene", + "text": "Since 1990 the University Hospital of Tromso has provided local hospitals in northern Norway with a remote frozen section service and with access to video conferences for the review of microscopic findings and for the discussion of major diagnostic issues .", + "entities": [] + }, + { + "id": "2854", + "type": "gene", + "text": "Two hundred forty - three patients have received WR - 2721 in Phase I - II studies .", + "entities": [] + }, + { + "id": "2855", + "type": "gene", + "text": "Catha edulis , a plant that has amphetamine effects .", + "entities": [] + }, + { + "id": "2856", + "type": "gene", + "text": "Tumor - like accumulation on Tl - 201 SPECT in subacute hemorrhagic cerebral infarction .", + "entities": [] + }, + { + "id": "2857", + "type": "gene", + "text": "The effects of two levels of caffeine ingestion on excess postexercise oxygen consumption in untrained women .", + "entities": [] + }, + { + "id": "2858", + "type": "gene", + "text": "Collectively , these and previously published data suggest a model where NS1 recruits eIF4GI specifically to the 5 ' untranslated region ( 5 ' UTR ) of the viral mRNA , allowing for the preferential translation of the influenza virus messengers .", + "entities": [ + "NS1", + "eIF4GI" + ] + }, + { + "id": "2859", + "type": "gene", + "text": "Abnormalities of plasma cholecystokinin were observed only in patients with delayed gastric emptying .", + "entities": [ + "plasma cholecystokinin" + ] + }, + { + "id": "2860", + "type": "gene", + "text": "The pilE gene product of Pseudomonas aeruginosa , required for pilus biogenesis , shares amino acid sequence identity with the N - termini of type 4 prepilin proteins .", + "entities": [ + "pilE gene product of Pseudomonas aeruginosa", + "type 4 prepilin proteins" + ] + }, + { + "id": "2861", + "type": "gene", + "text": "RESULTS : During the 7 - year period , 10 , 331 symptomatic duodenal ulcer diseases were diagnosed .", + "entities": [] + }, + { + "id": "2862", + "type": "gene", + "text": "The sacT gene regulating the sacPA operon in Bacillus subtilis shares strong homology with transcriptional antiterminators .", + "entities": [ + "sacT gene", + "sacPA operon in Bacillus subtilis" + ] + }, + { + "id": "2863", + "type": "gene", + "text": "Bisoprolol was found to be an effective beta - adrenoceptor antagonist , the pA2 values determined against isoprenaline in guinea pig atria and tracheal muscle being 7 . 45 and 6 . 41 , respectively .", + "entities": [ + "beta - adrenoceptor" + ] + }, + { + "id": "2864", + "type": "gene", + "text": "The partial farm budget highlighted the importance of reducing sub - clinical lesions in a feedlot .", + "entities": [] + }, + { + "id": "2865", + "type": "gene", + "text": "Furthermore , co - expression of both p46 and p54 subunits markedly altered the subcellular distribution of p46 ; co - expressed p46 was transported into the nucleus as efficiently as p54 .", + "entities": [ + "p46", + "p54 subunits", + "p46", + "p46", + "p54" + ] + }, + { + "id": "2866", + "type": "gene", + "text": "Timing of symptoms and oocyst excretion in human cryptosporidiosis .", + "entities": [] + }, + { + "id": "2867", + "type": "gene", + "text": "The data suggest that plasminogen , alpha 2AP , and C1 - INH , should be considered equine acute - phase proteins .", + "entities": [ + "plasminogen", + "alpha 2AP", + "C1 - INH" + ] + }, + { + "id": "2868", + "type": "gene", + "text": "65 , 3829 - 3838 , 1991 ) , a truncated form of the IE polypeptide lacking IE amino acid residues 1 - 322 ( and , therefore lacks the deduced transcriptional activation domain ) , fails to transactivate the EHV - 1 tk promoter , but retains the ability to down - regulate the EHV - 1 IE promoter .", + "entities": [ + "IE polypeptide", + "IE amino acid residues 1 - 322", + "EHV - 1 tk promoter", + "EHV - 1 IE promoter" + ] + }, + { + "id": "2869", + "type": "gene", + "text": "The elevated Viso V in the RDS group suggests an increase in small airway resistance secondary to the disease or to its therapy .", + "entities": [] + }, + { + "id": "2870", + "type": "gene", + "text": "Percentages of recovery for overload and dilution tests were between 87 and 120 % .", + "entities": [] + }, + { + "id": "2871", + "type": "gene", + "text": "Commonly observed systemic toxic effects ( bone marrow , gastrointestinal tract , and heart ) were not seen in this study .", + "entities": [] + }, + { + "id": "2872", + "type": "gene", + "text": "Finally , the pathophysiological aspects of urinary acidification are discussed , focusing on renal tubular acidosis models ( induced by maleate and amphotericin B treatment ) and their cellular mechanisms , as well as the role of adrenal steroids in urinary acidification .", + "entities": [] + }, + { + "id": "2873", + "type": "gene", + "text": "Based on these results , a new model for the regulation of nif / fix gene expression in A . caulinodans is proposed .", + "entities": [ + "nif", + "fix" + ] + }, + { + "id": "2874", + "type": "gene", + "text": "Plasma concentrations of ANF ( pANF ) , aldosterone ( PAC ) and renin ( PRC ) were measured daily , as were hemodynamic parameters .", + "entities": [ + "ANF", + "pANF", + "renin", + "PRC" + ] + }, + { + "id": "2875", + "type": "gene", + "text": "We have isolated and characterized the GCD6 and GCD7 genes and shown that their products are required to repress GCN4 translation under nonstarvation conditions .", + "entities": [ + "GCD6", + "GCD7 genes", + "GCN4" + ] + }, + { + "id": "2876", + "type": "gene", + "text": "Four out of 10 patients showed clinical improvement according to Ritchie - Index , pain score , ESR and CRP .", + "entities": [ + "CRP" + ] + }, + { + "id": "2877", + "type": "gene", + "text": "Using these antibodies , we were able to define the conditions to completely solubilize the Cdc25 protein .", + "entities": [ + "Cdc25 protein" + ] + }, + { + "id": "2878", + "type": "gene", + "text": "The Escherichia coli tet - repressor ( TetR ) operator system was used to develop a variation of the yeast two - hybrid assay in which disruptions of protein - protein interactions can be identified by a positive selection .", + "entities": [ + "Escherichia coli tet - repressor", + "TetR" + ] + }, + { + "id": "2879", + "type": "gene", + "text": "Role of the 3 ' untranslated region of baculovirus p10 mRNA in high - level expression of foreign genes .", + "entities": [ + "baculovirus p10 mRNA" + ] + }, + { + "id": "2880", + "type": "gene", + "text": "Pyrethroid insecticides are widely used in agriculture and private households .", + "entities": [] + }, + { + "id": "2881", + "type": "gene", + "text": "CXCR4 is a chemokine receptor and a coreceptor for T - cell - line - tropic ( X4 ) and dual - tropic ( R5X4 ) human immunodeficiency virus type 1 ( HIV - 1 ) isolates .", + "entities": [ + "CXCR4" + ] + }, + { + "id": "2882", + "type": "gene", + "text": "Activation of T cells via the TCR and other costimulatory receptors triggers a number of signaling cascades .", + "entities": [ + "TCR" + ] + }, + { + "id": "2883", + "type": "gene", + "text": "Isomers were differentiated based on the MS - MS data of the trofluoroacetyl - biphenylol derivatives .", + "entities": [] + }, + { + "id": "2884", + "type": "gene", + "text": "Doxorubicin ( DOX ) is commonly used for the treatment of hematological and solid tumors .", + "entities": [] + }, + { + "id": "2885", + "type": "gene", + "text": "Net lift and combined drag from all 8 bearings of the 4 - bladed impeller are compared with predictions based on 2 - D theory .", + "entities": [] + }, + { + "id": "2886", + "type": "gene", + "text": "The proofreading domain of Escherichia coli DNA polymerase I and other DNA and / or RNA exonuclease domains .", + "entities": [ + "Escherichia coli DNA polymerase I", + "DNA and / or RNA exonuclease domains" + ] + }, + { + "id": "2887", + "type": "gene", + "text": "In the second experiment , a stable nickel isotope , 61Ni , was given in drinking water to 20 nickel - sensitized women and 20 age - matched controls , both groups having vesicular hand eczema of the pompholyx type .", + "entities": [] + }, + { + "id": "2888", + "type": "gene", + "text": "When cotransfected in fibroblasts with a C / EBP alpha expression vector , reporter gene expression increased 3 - fold only in the wild - type constructs .", + "entities": [ + "C / EBP alpha" + ] + }, + { + "id": "2889", + "type": "gene", + "text": "Three high mobility group - like sequences within a 48 - base pair enhancer of the Col2a1 gene are required for cartilage - specific expression in vivo .", + "entities": [ + "high mobility group - like sequences", + "Col2a1 gene" + ] + }, + { + "id": "2890", + "type": "gene", + "text": "The loop domain of heat shock transcription factor 1 dictates DNA - binding specificity and responses to heat stress .", + "entities": [ + "heat shock transcription factor 1" + ] + }, + { + "id": "2891", + "type": "gene", + "text": "A simple method for measuring urinary iron following the administration of desferrioxamine ( DF ) is described .", + "entities": [] + }, + { + "id": "2892", + "type": "gene", + "text": "Since each transcript appears to encode the same protein , this complexity may reflect the need for lineage - specific or differentiation - dependent control of expression .", + "entities": [] + }, + { + "id": "2893", + "type": "gene", + "text": "However , with the alpha1 antagonist prazosin ( 5 x 10 ( - 8 ) - 5 x 10 ( - 7 ) M ) , no relaxation occurred .", + "entities": [] + }, + { + "id": "2894", + "type": "gene", + "text": "Regarding gestational risk , 3 , 243 drugs used ( 34 % ) belonged to category A risk , 1 , 923 ( 22 . 6 % ) to category B , 3 , 798 ( 39 . 7 % ) to category C , 289 ( 3 . 0 % ) to category D , and 55 ( 0 . 6 % ) to category X .", + "entities": [] + }, + { + "id": "2895", + "type": "gene", + "text": "In a highly select group of stable hypertensive patients , we have assessed the strength of association between various blood pressure measurements ( 24 h average automated ambulatory blood pressure , 4 h automated ambulatory morning average blood pressure , multiple office visit average blood pressure , and a single office visit average blood pressure ) and various echocardiographic indices of hypertensive cardiac target organ damage ( left atrial diameter , left ventricular end diastolic diameter , posterior wall thickness , combined wall thickness , relative wall thickness , left ventricular mass and mass index , and combined wall thickness / left ventricular diastolic diameter ratio ) .", + "entities": [] + }, + { + "id": "2896", + "type": "gene", + "text": "The other is located at - 1335 , outside this highly conserved region .", + "entities": [] + }, + { + "id": "2897", + "type": "gene", + "text": "Optimal monitoring of ODA remains undefined .", + "entities": [] + }, + { + "id": "2898", + "type": "gene", + "text": "An element within the 5 ' untranslated region of human Hsp70 mRNA which acts as a general enhancer of mRNA translation .", + "entities": [ + "human Hsp70 mRNA" + ] + }, + { + "id": "2899", + "type": "gene", + "text": "Microcomputer management of chronic hepatitis B virus asymptomatic patients", + "entities": [] + }, + { + "id": "2900", + "type": "gene", + "text": "Fourteen different species ( eight Platyhelmintha , one Nematoda and five Crustacea ) have been inventorized .", + "entities": [] + }, + { + "id": "2901", + "type": "gene", + "text": "The therapeutic protocole used at the Gustave Roussy Institute for invasive epithelioma of the uterine cervix rests , for limited forms ( T1B - T2 proximal ) , on combined radiology and surgery .", + "entities": [] + }, + { + "id": "2902", + "type": "gene", + "text": "Similarity of DNA binding and transcriptional regulation by Caenorhabditis elegans MAB - 3 and Drosophila melanogaster DSX suggests conservation of sex determining mechanisms .", + "entities": [ + "Caenorhabditis elegans MAB - 3", + "Drosophila melanogaster DSX" + ] + }, + { + "id": "2903", + "type": "gene", + "text": "NGF elicits a more delayed and sustained ERK phosphorylation than EGF , consistent with previous reports .", + "entities": [ + "NGF", + "ERK", + "EGF" + ] + }, + { + "id": "2904", + "type": "gene", + "text": "GRP78 , a molecular chaperone expressed in the endoplasmic reticulum , is a \" glucose - regulated protein \" induced by stress responses that deplete glucose or intracisternal calcium or otherwise disrupt glycoprotein trafficking .", + "entities": [ + "GRP78" + ] + }, + { + "id": "2905", + "type": "gene", + "text": "Electrocardiographic right ventricular hypertrophy was seen in 4 , and biventricular hypertrophy in 5 patients .", + "entities": [] + }, + { + "id": "2906", + "type": "gene", + "text": "Evidence from a Northern hybridization indicated that jadM expression is correlated with jadomycin B synthesis .", + "entities": [ + "jadM", + "jadomycin B" + ] + }, + { + "id": "2907", + "type": "gene", + "text": "We report here on the molecular nature of an EMS - induced mutant , mn1 - 89 , a leaky semidominant allele of the Miniature1 ( Mn1 ) seed locus that encodes a seed - specific cell wall invertase , INCW2 .", + "entities": [ + "mn1 - 89", + "Miniature1", + "Mn1", + "seed - specific cell wall invertase", + "INCW2" + ] + }, + { + "id": "2908", + "type": "gene", + "text": "Practical interest of such studies is limited since the pharmacokinetic parameters are systematically evaluated in man during phase I trials .", + "entities": [] + }, + { + "id": "2909", + "type": "gene", + "text": "In vitro DNase I footprinting showed that OxyR - C199S protected Pmom from - 104 to - 46 on the top strand and produced a protection pattern characteristic of reduced wild - type OxyR .", + "entities": [ + "DNase I", + "OxyR - C199S", + "Pmom", + "reduced wild - type OxyR" + ] + }, + { + "id": "2910", + "type": "gene", + "text": "The function of the C - terminal tail in telomere maintenance is not mediated through the RAP1 interacting factor RIF1 : rap1 alleles defective in both the C - terminal tail and RIF1 interaction domains have additive effects on telomere length .", + "entities": [ + "RIF1", + "rap1 alleles", + "RIF1 interaction domains" + ] + }, + { + "id": "2911", + "type": "gene", + "text": "A reduction in blood pressure was only observed at the end of the study , from 142 + / - 17 / 86 . 6 + / - 9 . 1 to 139 + / - 13 / 82 . 9 + / - 8 . 9 mmHg ( P less than 0 . 05 for DBP ) .", + "entities": [] + }, + { + "id": "2912", + "type": "gene", + "text": "No UOxase mRNA was detected in 11 nonhepatic tissues of rat , suggesting tissue specificity of expression of this UOxase gene .", + "entities": [ + "UOxase mRNA", + "UOxase gene" + ] + }, + { + "id": "2913", + "type": "gene", + "text": "The subepicardial lymphatic capillaries were ramified and anastomosed with each other to form a relatively dense network which extended over the entire surface of both ventricles .", + "entities": [] + }, + { + "id": "2914", + "type": "gene", + "text": "This could lead to subsequent outbreaks if Babesia carrier animals were to be introduced into the herd .", + "entities": [] + }, + { + "id": "2915", + "type": "gene", + "text": "The plasmatic albumin concentration ( 3 . 5 - 4 . 5 g / dl ) represents about 60 % of the total plasma protein .", + "entities": [ + "plasmatic albumin" + ] + }, + { + "id": "2916", + "type": "gene", + "text": "It may be dependent on location of a focus ( according to EEG ) as well as on the character and manifestation of the accompanying neuropsychologic symptomatology .", + "entities": [] + }, + { + "id": "2917", + "type": "gene", + "text": "Other assays also distinguished the processive replication of pNeo . Myc - 2 . 4 from the dispersive labeling of control plasmids .", + "entities": [] + }, + { + "id": "2918", + "type": "gene", + "text": "In electrophoretic mobility shift assay ( EMSA ) , this GLUT4 repressor element ( G4RE ) generated specific bands with nuclear extracts from preadipocytes , but not from adipocytes .", + "entities": [ + "GLUT4 repressor element", + "G4RE" + ] + }, + { + "id": "2919", + "type": "gene", + "text": "Saccharomyces cerevisiae contains a genetically and biochemically proven CAK gene , CAK1 , that encodes a monomeric 44 - kDa Cak1p protein unrelated to Cdk7 .", + "entities": [ + "CAK gene", + "CAK1", + "44 - kDa Cak1p protein", + "Cdk7" + ] + }, + { + "id": "2920", + "type": "gene", + "text": "In contrast , in LL patients during ENL the ConA - induced suppressor response was markedly reduced .", + "entities": [ + "ConA" + ] + }, + { + "id": "2921", + "type": "gene", + "text": "In the presence of the in vivo reducing system ( thioredoxin , thioredoxin reductase , and NADPH ) , however , each of these mutants catalyzed the formation of only 0 . 6 - 0 . 8 dCTPs per mole of enzyme .", + "entities": [ + "thioredoxin", + "thioredoxin reductase" + ] + }, + { + "id": "2922", + "type": "gene", + "text": "The SH3 domains of Grb2 bound in vitro to specific proline - rich motifs in the HPK1 tail and functioned synergistically to direct the stable binding of Grb2 to HPK1 in transfected Cos1 cells .", + "entities": [ + "SH3 domains", + "Grb2", + "HPK1", + "Grb2", + "HPK1" + ] + }, + { + "id": "2923", + "type": "gene", + "text": "The recombinant purified protein expressed in the baculovirus system had an approximate molecular size 20 kDa with amino - terminal sequence of AVQGP .", + "entities": [] + }, + { + "id": "2924", + "type": "gene", + "text": "Cholesterol side - chain cleavage cytochrome P450 ( CYP11A ; P450scc ) gene expression is regulated by gonadotropins via cAMP in the ovary and by ACTH via cAMP in adrenal cortical cells .", + "entities": [ + "Cholesterol side - chain cleavage cytochrome P450", + "CYP11A", + "P450scc", + "gonadotropins", + "ACTH" + ] + }, + { + "id": "2925", + "type": "gene", + "text": "Efficacy was determined by responses to question 3 ( ability to achieve an erection ) and question 4 ( ability to maintain an erection ) of the 15 - item International Index of Erectile Function ( IIEF ) .", + "entities": [] + }, + { + "id": "2926", + "type": "gene", + "text": "Immunodepression was combined with the increase of glucocorticoid activity of adrenal cortex , while no significant changes in thyroid hormones were registered .", + "entities": [] + }, + { + "id": "2927", + "type": "gene", + "text": "The basal promoter elements of murine cytochrome c oxidase subunit IV gene consist of tandemly duplicated ets motifs that bind to GABP - related transcription factors .", + "entities": [ + "murine cytochrome c oxidase subunit IV gene", + "ets", + "GABP - related transcription factors" + ] + }, + { + "id": "2928", + "type": "gene", + "text": "The trk - 2h oncogene , isolated from the human breast carcinoma cell line MDA - MB 231 by genomic DNA - transfection into NIH3T3 cells , consists of the trk proto - oncogene receptor kinase domain fused to a N - terminal 41 amino acid activating sequence ( Kozma , S . C . , Redmond , S . M . S . , Xiao - Chang , F . , Saurer , S . M . , Groner , B . and Hynes , N . E .", + "entities": [ + "trk - 2h oncogene", + "trk proto - oncogene receptor kinase domain" + ] + }, + { + "id": "2929", + "type": "gene", + "text": "Repeated efforts to isolate recombinant baculoviruses containing a wild - type kinase failed , whereas recombinants expressing a nonfunctional kinase with a catalytic domain II mutation were readily isolated .", + "entities": [] + }, + { + "id": "2930", + "type": "gene", + "text": "Serum concentrations of E2 and TBOH were measured on d 0 , 1 , 3 , 5 , 7 , 13 , 21 , 28 , 42 , 56 , 84 , 112 , and 140 in finishing heifers administered the following treatments : 1 ) control ; 2 ) MGA , . 5 mg per heifer daily ; 3 ) Revalor - H ( 140 mg TBA + 14 mg E2 ) ; 4 ) Revalor - H + MGA ; 5 ) Finaplix - H ( 200 mg TBA ) ; and 6 ) Finaplix - H + MGA .", + "entities": [] + }, + { + "id": "2931", + "type": "gene", + "text": "Recombinant human TFIID supported weak basal transcription in heat - treated nuclear extracts whereas a partially purified TFIID fraction from HeLa cells reconstituted a maximal level of transcription .", + "entities": [ + "Recombinant human TFIID", + "TFIID" + ] + }, + { + "id": "2932", + "type": "gene", + "text": "Variable FHR decelerations or bradycardias were encountered on 95 nonstress tests ( 18 . 8 % ) in 80 ( 33 . 5 % ) postdate patients .", + "entities": [] + }, + { + "id": "2933", + "type": "gene", + "text": "The Fis protein regulates site - specific DNA inversion catalyzed by a family of DNA invertases when bound to a cis - acting recombinational enhancer .", + "entities": [ + "Fis protein", + "DNA invertases" + ] + }, + { + "id": "2934", + "type": "gene", + "text": "Daily and seasonal rhythmicity in the methylation of pineal indolic compounds in adult male golden hamsters , kept under natural conditions .", + "entities": [] + }, + { + "id": "2935", + "type": "gene", + "text": "When the coronary sinus pressure reached 15 torr , there was a significant decrease in cardiac index ( 3 . 60 + / - 0 . 5 to 2 . 70 + / - 0 . 6 L / min / m2 , p less than 0 . 001 ) , coronary blood flow ( 13 . 7 + / - 3 . 1 to 7 . 0 + / - 2 . 1 ml / min , p less than 0 . 001 ) , rate of rise of left ventricular pressure ( 1 , 567 + / - 275 to 1 , 331 + / - 314 , p less than 0 . 05 ) , and an increase in coronary arteriovenous difference ( 62 . 8 % + / - 9 . 3 % to 70 . 5 % + / - 5 . 4 % saturation , p less than 0 . 03 ) .", + "entities": [] + }, + { + "id": "2936", + "type": "gene", + "text": "Prevalence of rheumatoid arthritis and rheumatoid factor in women : evidence for a secular decline .", + "entities": [ + "rheumatoid factor" + ] + }, + { + "id": "2937", + "type": "gene", + "text": "New technologies in diagnosis and classification of malignancy .", + "entities": [] + }, + { + "id": "2938", + "type": "gene", + "text": "Five control subjects with COPD , who performed the same sequence of tests without breathing 30 % O2 , showed no change in flow rates or density dependence .", + "entities": [] + }, + { + "id": "2939", + "type": "gene", + "text": "Note on Slot ' s method for the specific determination of creatinine .", + "entities": [] + }, + { + "id": "2940", + "type": "gene", + "text": "Rex - 1 , a gene encoding a transcription factor expressed in the early embryo , is regulated via Oct - 3 / 4 and Oct - 6 binding to an octamer site and a novel protein , Rox - 1 , binding to an adjacent site .", + "entities": [ + "Rex - 1", + "Oct - 3 / 4", + "Oct - 6", + "Rox - 1" + ] + }, + { + "id": "2941", + "type": "gene", + "text": "Expression of herpes simplex virus beta and gamma genes integrated in mammalian cells and their induction by an alpha gene product .", + "entities": [] + }, + { + "id": "2942", + "type": "gene", + "text": "Recombinant AROM - p64 displayed high binding to single - stranded DNA and poly ( A ) homopolymers suggesting that this protein could play a role in mRNA maturation / metabolism .", + "entities": [ + "AROM", + "p64" + ] + }, + { + "id": "2943", + "type": "gene", + "text": "The P13 and N22 of ppSEPs had phase reversal relationship with the P2 and N2 recorded from the PES , respectively .", + "entities": [] + }, + { + "id": "2944", + "type": "gene", + "text": "The nit - 3 gene of the filamentous fungus Neurospora crassa encodes nitrate reductase , the enzyme which catalyzes the first step in nitrate assimilation .", + "entities": [ + "nit - 3 gene of the filamentous fungus Neurospora crassa", + "nitrate reductase" + ] + }, + { + "id": "2945", + "type": "gene", + "text": "Within a 135 - bp core homology region , the human HS12 enhancers are approximately 90 % identical to the murine homolog and include several motifs previously demonstrated to be important for function of the murine enhancer ; additional segments of high sequence conservation suggest the possibility of previously unrecognized functional motifs .", + "entities": [ + "human HS12 enhancers" + ] + }, + { + "id": "2946", + "type": "gene", + "text": "In the first group , 0 . 02 % Prazosin ( 0 . 5 mg / kg ) was administered intravenously for 1 . 5 hours before the application of Oxy - Hb or PGF2 alpha .", + "entities": [] + }, + { + "id": "2947", + "type": "gene", + "text": "Tctex - 1 binding required the first 19 amino acids of Fyn and integrity of two lysine residues within this sequence that were previously shown to be important for Fyn interactions with the immunoreceptor tyrosine - based activation motifs ( ITAMs ) of lymphocyte Ag receptors .", + "entities": [ + "Tctex - 1", + "Fyn", + "Fyn", + "lymphocyte Ag receptors" + ] + }, + { + "id": "2948", + "type": "gene", + "text": "In the present study , we sought to investigate whether constitutive NF - kappaB activity in chronically HIV - 1 - infected promonocytic U937 ( U9 - IIIB ) and myeloblastic PLB - 985 ( PLB - IIIB ) cells affects apoptotic signaling .", + "entities": [ + "NF - kappaB" + ] + }, + { + "id": "2949", + "type": "gene", + "text": "Although most SFV genes have homologs encoded by other Chordopoxvirinae , the SFV genome lacks a key gene required for the production of extracellular enveloped virus .", + "entities": [] + }, + { + "id": "2950", + "type": "gene", + "text": "Increased granulocyte - colony stimulating factor ( G - CSF ) levels in neonates with perinatal complications .", + "entities": [ + "granulocyte - colony stimulating factor", + "G - CSF" + ] + }, + { + "id": "2951", + "type": "gene", + "text": "It brings about fatigue , negative moods , and impaired health , sleep , safety , and working capacity .", + "entities": [] + }, + { + "id": "2952", + "type": "gene", + "text": "Interdomain signaling in a two - domain fragment of the human glucocorticoid receptor .", + "entities": [ + "human glucocorticoid receptor" + ] + }, + { + "id": "2953", + "type": "gene", + "text": "Basal FVR was reduced by approximately 18 % by ERT and HRT , but FVR responses to noradrenaline , angiotensin II , acetylcholine and nitroprusside were unaffected .", + "entities": [ + "angiotensin II" + ] + }, + { + "id": "2954", + "type": "gene", + "text": "Role of biocenosis in the manifestation of Shigella virulence", + "entities": [] + }, + { + "id": "2955", + "type": "gene", + "text": "The ubiquitously expressed E12 bHLH protein dimerizes with numerous cell - specific bHLH factors .", + "entities": [ + "E12 bHLH protein", + "bHLH factors" + ] + }, + { + "id": "2956", + "type": "gene", + "text": "We tried amphotericin B ( AmB ) , and remission of the tumor was obtained .", + "entities": [] + }, + { + "id": "2957", + "type": "gene", + "text": "Homozygous mutant mice , designated Cux / CDPDeltaCR1 , display a phenotype characterized by curly vibrissae and wavy hair .", + "entities": [ + "Cux", + "CDPDeltaCR1" + ] + }, + { + "id": "2958", + "type": "gene", + "text": "It is concluded that suppression of elevated prolactin levels in progressive metastatic breast cancer patients is not effective in restoring tumor sensitivity to chemotherapy .", + "entities": [ + "prolactin" + ] + }, + { + "id": "2959", + "type": "gene", + "text": "This protein can bind to a region of the promoter of an Arabidopsis light - harvesting chlorophyll a / b protein gene , Lhcb1 * 3 , which is necessary for its regulation by phytochrome .", + "entities": [ + "Arabidopsis light - harvesting chlorophyll a / b protein gene", + "Lhcb1 * 3", + "phytochrome" + ] + }, + { + "id": "2960", + "type": "gene", + "text": "12 - O - Tetradecanoylphorbol 13 - acetate was found to inhibit rapidly and potently the expression of mRNAs coding for the myogenic regulators CMD1 and myogenin .", + "entities": [ + "CMD1", + "myogenin" + ] + }, + { + "id": "2961", + "type": "gene", + "text": "Sequential cleavage by metallopeptidases and proteasomes is involved in processing HIV - 1 ENV epitope for endogenous MHC class I antigen presentation .", + "entities": [ + "metallopeptidases", + "HIV - 1 ENV epitope", + "MHC class I antigen" + ] + }, + { + "id": "2962", + "type": "gene", + "text": "Comparison with the crystal structure of Desulfovibrio gigas , Dg , Fd ( Kissinger et al . , 1991 ) reveals a very similar folding topology , although several secondary structural elements are extended in Pf relative to Dg Fd .", + "entities": [ + "Fd", + "Fd" + ] + }, + { + "id": "2963", + "type": "gene", + "text": "Unified theory of segregated - stack organic charge - transfer solids : Magnetic properties .", + "entities": [] + }, + { + "id": "2964", + "type": "gene", + "text": "Sequencing analysis has shown that each rap1t allele contains a nonsense mutation within a discrete region between amino acids 663 and 684 .", + "entities": [ + "rap1t allele" + ] + }, + { + "id": "2965", + "type": "gene", + "text": "Aluminium resin for the treatment of the hyperkalamia of renal failure .", + "entities": [] + }, + { + "id": "2966", + "type": "gene", + "text": "Selenium is an essential element for humans , animals and some species of microorganisms .", + "entities": [] + }, + { + "id": "2967", + "type": "gene", + "text": "Saccharomyces cerevisiae activates a regulatory network called \" general control \" that provides the cell with sufficient amounts of protein precursors during amino acid starvation .", + "entities": [] + }, + { + "id": "2968", + "type": "gene", + "text": "Results indicate that KNM - LU 335 differs from both human and chimpanzee M1s in relative distances ( measured in three dimensions ) between crown fissure termini .", + "entities": [] + }, + { + "id": "2969", + "type": "gene", + "text": "Bacillus cereus cross - infection in a maternity - unit .", + "entities": [] + }, + { + "id": "2970", + "type": "gene", + "text": "These results indicate that in addition to Grb2 - mediated activation of Ras , PLC - gamma1 - mediated DAG production is required for EGF - and PDGF - induced S - phase entry and gene expression , possibly through activation of PKC .", + "entities": [ + "Grb2", + "Ras", + "PLC - gamma1", + "EGF", + "PDGF", + "PKC" + ] + }, + { + "id": "2971", + "type": "gene", + "text": "Four CsA - treated patients developed persistently elevated UAER > 30 mg / 24 h ( n = 3 with microalbuminuria ) , whereas all the 17 placebo - treated patients had normal UAER ( < 30 mg / 24 h ) after 7 years of follow - up .", + "entities": [] + }, + { + "id": "2972", + "type": "gene", + "text": "Weight and height z - scores were significantly associated with BMD z - scores .", + "entities": [] + }, + { + "id": "2973", + "type": "gene", + "text": "Prophylactic lymph node dissection or radiation therapy to the nodal chain may decrease local recurrence but does not consistently affect overall survival .", + "entities": [] + }, + { + "id": "2974", + "type": "gene", + "text": "Ovarian allotransplantation in human .", + "entities": [] + }, + { + "id": "2975", + "type": "gene", + "text": "Echinococcus granulosus was diagnosed by fine - needle aspiration cytology of a lung cyst in a 6 - yr - old white female in central Missouri .", + "entities": [] + }, + { + "id": "2976", + "type": "gene", + "text": "Furthermore , in vitro decay reaction mixtures supplemented with the 20 - nt sense RNA transcript resulted in stabilization of R2 message .", + "entities": [ + "R2 message" + ] + }, + { + "id": "2977", + "type": "gene", + "text": "Thus , the nematode genes could be the homologs of Hh molecules in other phyla .", + "entities": [ + "homologs of Hh molecules" + ] + }, + { + "id": "2978", + "type": "gene", + "text": "Utilizing transient transfection studies in HepG2 cells , we have shown that deletion of the factor VIII promoter sequences distal to nucleotide - 44 results in a significant but small increase in promoter activity .", + "entities": [ + "factor VIII promoter sequences" + ] + }, + { + "id": "2979", + "type": "gene", + "text": "Teicoplanin was given most often because of persistent fever or initial Gram - positive bacteraemia and only one - third of these cases responded .", + "entities": [] + }, + { + "id": "2980", + "type": "gene", + "text": "Similarly , the DNA - binding activity of activator protein 1 ( AP - 1 ) is modified by a DNA repair enzyme , redox factor 1 ( Ref - 1 ) , which is identical to a DNA repair enzyme , AP endonuclease .", + "entities": [ + "activator protein 1", + "AP - 1", + "DNA repair enzyme", + "redox factor 1", + "Ref - 1", + "DNA repair enzyme", + "AP endonuclease" + ] + }, + { + "id": "2981", + "type": "gene", + "text": "A cdc33 - 1 strain expressing either stable Cln3p ( Cln3 - 1p ) or a hybrid UBI4 5 ' - CLN3 mRNA , whose translation displays decreased dependence on eIF4E , arrested randomly in the cell cycle .", + "entities": [ + "cdc33 - 1", + "Cln3p", + "Cln3 - 1p", + "UBI4 5 ' - CLN3", + "eIF4E" + ] + }, + { + "id": "2982", + "type": "gene", + "text": "The rate - decreasing effects of morphine and U50488 were reversed completely by a 0 . 01 and 1 . 0 mg / kg dose of naloxone , respectively .", + "entities": [] + }, + { + "id": "2983", + "type": "gene", + "text": "We have recently identified a mouse enzyme termed gamma - glutamyl leukotrienase ( GGL ) that converts leukotriene C4 ( LTC4 ) to leukotriene D4 ( LTD4 ) .", + "entities": [ + "gamma - glutamyl leukotrienase", + "GGL" + ] + }, + { + "id": "2984", + "type": "gene", + "text": "[ Diabetologia ( 2001 ) 44 [ Suppl 3 ] : B37 - B44 ]", + "entities": [] + }, + { + "id": "2985", + "type": "gene", + "text": "Effects of perceptual salience on the matrix task performance of four - and six - year - old children .", + "entities": [] + }, + { + "id": "2986", + "type": "gene", + "text": "End - tidal PO2 and the ratio of minute ventilation to oxygen consumption ( VE / VO2 ) were lower while PETCO2 was higher for Hyp ( P < or = 0 . 01 ) .", + "entities": [] + }, + { + "id": "2987", + "type": "gene", + "text": "A candidate gene for Bcg , designated natural resistance - associated macrophage protein ( Nramp ) , has been isolated and shown to encode a novel macrophage - specific membrane protein , which is altered in susceptible animals .", + "entities": [ + "Bcg", + "natural resistance - associated macrophage protein", + "Nramp" + ] + }, + { + "id": "2988", + "type": "gene", + "text": "Initiation of translation of the human hepatitis C virus ( HCV ) RNA genome occurs by internal ribosome entry into the 5 ' noncoding region ( 5 ' NCR ) in a cap - independent manner .", + "entities": [] + }, + { + "id": "2989", + "type": "gene", + "text": "An epidemic of hepatitis B virus infection among intravenous drug users in Iceland .", + "entities": [] + }, + { + "id": "2990", + "type": "gene", + "text": "These results indicate that TGF - betaf potentiates the c - fos SRE activated by PKC through the SRF binding site .", + "entities": [ + "TGF - betaf", + "c - fos", + "PKC", + "SRF binding site" + ] + }, + { + "id": "2991", + "type": "gene", + "text": "Static magnetic fields affect the diffusion of biological particles in solutions through the Lorentz force and Maxwell stress .", + "entities": [] + }, + { + "id": "2992", + "type": "gene", + "text": "In addition , the mouse ortholog ( Mharp / Smarcal1 ) was cloned , and the Caenorhabditis elegans ortholog ( CEHARP ) was identified in the GenBank database .", + "entities": [ + "Mharp", + "Smarcal1", + "CEHARP" + ] + }, + { + "id": "2993", + "type": "gene", + "text": "Since 1967 at the times of their biennial ABCC / RERF radiological examinations , all Adult Health Study ( AHS ) subjects have been interviewed to determine the exposures to medical x - rays they experienced in institutions other than RERF in order to estimate the numbers of examinations and corresponding doses which they received .", + "entities": [] + }, + { + "id": "2994", + "type": "gene", + "text": "This action is dependent on helix - loop - helix factors bound to the E1 element .", + "entities": [ + "helix - loop - helix factors", + "E1" + ] + }, + { + "id": "2995", + "type": "gene", + "text": "NuA4 has an apparent molecular mass of 1 . 3 MDa .", + "entities": [ + "NuA4" + ] + }, + { + "id": "2996", + "type": "gene", + "text": "Four full - thickness skin incisions were made in the back of 10 female pigs that treated twice a day for 14 days with 2 ml of epidermal growth factor ( 300 ng / ml ) or 2 ml of Ringer ' s lactate solution in a single - blind , randomized fashion .", + "entities": [ + "epidermal growth factor" + ] + }, + { + "id": "2997", + "type": "gene", + "text": "Recurrent acute rhinosinusitis was common in both groups of patients , but the development of chronic rhinosinusitis was only found in patients with CVID , indicating the more severe nature of this condition compared with selective IgA deficiency .", + "entities": [ + "IgA" + ] + }, + { + "id": "2998", + "type": "gene", + "text": "Propranolol ( Inderal ) administered in a dose which blocks the beta - adrenergic apparatus of the heart prevents the development of the positive inotropic effect of therapeutic doses of strophanthin K on a hypodynamic left ventricular myocardium .", + "entities": [] + }, + { + "id": "2999", + "type": "gene", + "text": "Cord swelling was observed in 2 patients who developed complete lesions .", + "entities": [] + }, + { + "id": "3000", + "type": "gene", + "text": "This report presents an analysis of the vocal repertoire of howler monkeys ( Alouatta palliata ) observed during a field study in southwestern Panama .", + "entities": [] + }, + { + "id": "3001", + "type": "gene", + "text": "Solving an age old problem .", + "entities": [] + }, + { + "id": "3002", + "type": "gene", + "text": "The enhanced cysteine formation in a pCSK4F plant responding to sulfite was also observed in leaf discs .", + "entities": [] + }, + { + "id": "3003", + "type": "gene", + "text": "Comparison was made with other neuroradiological imaging modalities including CT , myelography , CT ventriculography , and CT myelocisternography .", + "entities": [] + }, + { + "id": "3004", + "type": "gene", + "text": "Serological studies of antibodies to Epstein - Barr virus in infectious mononucleosis", + "entities": [] + }, + { + "id": "3005", + "type": "gene", + "text": "Vac1p was found to bind the Sec1p homologue Vps45p .", + "entities": [ + "Vac1p", + "Vps45p" + ] + }, + { + "id": "3006", + "type": "gene", + "text": "Competition electrophoretic mobility shift and immunoshift assays confirmed that NF1 factors present in nuclear extracts of HeLa and CV - 1 cells bind to the BKV - MLP .", + "entities": [ + "NF1 factors", + "BKV - MLP" + ] + }, + { + "id": "3007", + "type": "gene", + "text": "We analyzed an EBV B - cell clone , E29 . 1 , derived from an 11 week - old embryo , and secreting both IgM kappa and IgM lambda .", + "entities": [ + "IgM kappa", + "IgM lambda" + ] + }, + { + "id": "3008", + "type": "gene", + "text": "Calibration and a correction of blood O2 content measured by Po2 and CO saturation .", + "entities": [] + }, + { + "id": "3009", + "type": "gene", + "text": "A fusion protein composed of beta - galactosidase and full - length Ahr translocates from the cytoplasm to the nucleus in a ligand - dependent manner .", + "entities": [ + "beta - galactosidase", + "full - length Ahr" + ] + }, + { + "id": "3010", + "type": "gene", + "text": "There was no correlation between secretor status and clinical status , spirometry measurements , salivary and serum lysozyme levels or rates of respiratory tract colonization with P . aeruginosa and S . aureus .", + "entities": [ + "serum lysozyme" + ] + }, + { + "id": "3011", + "type": "gene", + "text": "There was no correlation between secretor status and clinical status , spirometry measurements , salivary and serum lysozyme levels or rates of respiratory tract colonization with P . aeruginosa and S . aureus .", + "entities": [ + "salivary and serum lysozyme" + ] + }, + { + "id": "3012", + "type": "gene", + "text": "The transposon - inactivated gene , designated pilP , is 525 bp long , potentially encoding a 19 . 1 - kDa protein precursor that contains a typical membrane lipoprotein leader sequence .", + "entities": [ + "pilP" + ] + }, + { + "id": "3013", + "type": "gene", + "text": "We can classify antibiotics into two groups based on initial bactericidal activity against P . aeruginosa ; one class is antibiotics having rapid initial killing such as AMK , IPM and PAPM , the other is CAZ , MEPM showing slow initial killing .", + "entities": [] + }, + { + "id": "3014", + "type": "gene", + "text": "Rinit reflects the Newtonian resistances and Rdiff represents the viscoelastic / inhomogeneous pressure dissipations in the system .", + "entities": [] + }, + { + "id": "3015", + "type": "gene", + "text": "NF - kappaB plays a critical role in activation of HIV - 1 gene expression by cytokines and other stimuli , but the signal transduction pathways that regulate the switch from latent to productive infection have not been defined .", + "entities": [ + "NF - kappaB" + ] + }, + { + "id": "3016", + "type": "gene", + "text": "A rabbit antiserum was raised against a synthetic peptide corresponding to a hydrophilic portion of the translated murine cDNA sequence .", + "entities": [] + }, + { + "id": "3017", + "type": "gene", + "text": "Based on these results the minimal control element ( AX 470 ) specifying the anterior boundary of Hox expression was designated as Hoxa - 7 enhancer .", + "entities": [ + "Hox", + "Hoxa - 7 enhancer" + ] + }, + { + "id": "3018", + "type": "gene", + "text": "Immediately after surgery , dialysate PGE2 and adenosine concentrations were 3 . 7 + / - 0 . 7 and 296 + / - 127 nM , respectively .", + "entities": [] + }, + { + "id": "3019", + "type": "gene", + "text": "1 in Ho Chi Minh City was studied by culture and latex agglutination of blood , cerebrospinal fluid , urine and pleural fluid .", + "entities": [] + }, + { + "id": "3020", + "type": "gene", + "text": "No other changes in hematopoietic differentiation status were observed in association with Id - SCL expression .", + "entities": [ + "Id - SCL" + ] + }, + { + "id": "3021", + "type": "gene", + "text": "These results indicate that both naturally acquired and passive ( modified immune serum globulin ) antibodies to type III group B Streptococcus antigen are partially protective against intra - amniotic infection .", + "entities": [ + "immune serum globulin", + "type III group B Streptococcus antigen" + ] + }, + { + "id": "3022", + "type": "gene", + "text": "The various forms of sickle cell disease share the common feature of an abnormal globin chain that , under certain conditions such as hypoxia , results in the sickling of red blood cells and obstruction of blood vessels .", + "entities": [ + "globin chain" + ] + }, + { + "id": "3023", + "type": "gene", + "text": "Although p48 gene induction is dependent on STAT1 and JAK1 , activated STAT1 does not bind to GATE .", + "entities": [ + "p48 gene", + "STAT1", + "JAK1", + "STAT1", + "GATE" + ] + }, + { + "id": "3024", + "type": "gene", + "text": "Competition with a putative MADS box consensus binding site from the promoter of the coordinately regulated opaque - phase - specific gene PEP1 ( SAP1 ) and the human MADS box consensus binding site for serum response factor demonstrated that one of the three complexes formed was specific to the OP4 sequence .", + "entities": [ + "MADS box", + "opaque - phase - specific gene PEP1", + "SAP1", + "human MADS box consensus binding site", + "serum response factor", + "OP4 sequence" + ] + }, + { + "id": "3025", + "type": "gene", + "text": "The ipsilateral breast tumor relapse rate was similar between the PALP and MGDET groups .", + "entities": [] + }, + { + "id": "3026", + "type": "gene", + "text": "Plants transformed with the 35S - 1 - sst construct accumulated the oligofructans 1 - kestose ( GF2 ) , 1 , 1 - nystose ( GF3 ) and 1 , 1 , 1 - fructosylnystose ( GF4 ) .", + "entities": [ + "35S", + "1 - sst" + ] + }, + { + "id": "3027", + "type": "gene", + "text": "We conclude that androgenic hormones reduce HDL - cholesterol concentrations and the HDL2 - cholesterol subfraction , possibly by enhancing hepatic triglyceride lipase activity .", + "entities": [ + "HDL - cholesterol", + "HDL2 - cholesterol", + "hepatic triglyceride lipase" + ] + }, + { + "id": "3028", + "type": "gene", + "text": "Nitrogen balance was compared , and metabolic complications were monitored by evaluating BUN , serum creatinine , creatinine clearance , serum CO2 , SGOT , SGPT , serum LDH , and serum alkaline phosphatase .", + "entities": [ + "SGOT", + "SGPT", + "serum LDH", + "serum alkaline phosphatase" + ] + }, + { + "id": "3029", + "type": "gene", + "text": "We conclude that , both in atrial myocytes and in Xenopus oocytes , beta - adrenergic stimulation potentiates the ACh - evoked GIRK channels via a pathway that involves PKA - catalyzed phosphorylation downstream from beta ( 2 ) AR .", + "entities": [ + "GIRK channels", + "PKA", + "beta ( 2 ) AR" + ] + }, + { + "id": "3030", + "type": "gene", + "text": "The glial cyst wall was lined in part by flattened or cuboidal epithelium .", + "entities": [] + }, + { + "id": "3031", + "type": "gene", + "text": "PET activation studies are performed widely to study human brain function .", + "entities": [] + }, + { + "id": "3032", + "type": "gene", + "text": "The avidin - biotin complex peroxidase ( ABC - P ) method was used to detect Mycobacterium bovis , and the results were compared with those obtained by the Ziehl - Neelsen ( ZN ) technique .", + "entities": [ + "avidin - biotin complex peroxidase", + "ABC - P" + ] + }, + { + "id": "3033", + "type": "gene", + "text": "A hypothesis .", + "entities": [] + }, + { + "id": "3034", + "type": "gene", + "text": "Yap1p is constitutively nuclear in a crm1 mutant , and Crm1p binds to a nuclear export sequence ( NES ) - like sequence in Yap1p in the presence of RanGTP .", + "entities": [ + "Yap1p", + "crm1 mutant", + "Crm1p", + "Yap1p", + "RanGTP" + ] + }, + { + "id": "3035", + "type": "gene", + "text": "A small amount of HSP81 - 1 mRNA was detected only in roots .", + "entities": [ + "HSP81 - 1 mRNA" + ] + }, + { + "id": "3036", + "type": "gene", + "text": "The pCMBS - reactive sulfhydryl groups were located exclusively in the exofacial half of the plasma membrane and , when presented in a helical model , lie along one side of the helices .", + "entities": [] + }, + { + "id": "3037", + "type": "gene", + "text": "Cyclin G2 is highly expressed in the immune system where immunologic tolerance subjects self - reactive lymphocytes to negative selection and clonal deletion via apoptosis .", + "entities": [ + "Cyclin G2" + ] + }, + { + "id": "3038", + "type": "gene", + "text": "The Dax - 1 gene encodes a protein that is structurally related to members of the orphan nuclear receptor superfamily .", + "entities": [ + "Dax - 1 gene", + "orphan nuclear receptor superfamily" + ] + }, + { + "id": "3039", + "type": "gene", + "text": "Cloning of higher plant omega - 3 fatty acid desaturases .", + "entities": [ + "higher plant omega - 3 fatty acid desaturases" + ] + }, + { + "id": "3040", + "type": "gene", + "text": "Truncation variants of peptides isolated from MHC class II molecules suggest sequence motifs .", + "entities": [ + "MHC class II molecules" + ] + }, + { + "id": "3041", + "type": "gene", + "text": "No difference in elastin peptide concentration was observed between emphysematous patients and control subjects ( mean + / - SD = 2 . 39 + / - 1 . 18 micrograms / ml in patients versus 2 . 55 + / - 1 . 34 micrograms / ml in policemen and 2 . 59 + / - 1 . 20 micrograms / ml in coal miners ) .", + "entities": [ + "elastin peptide" + ] + }, + { + "id": "3042", + "type": "gene", + "text": "Newcastle disease virus surveillance in Hong Kong on local and imported poultry .", + "entities": [] + }, + { + "id": "3043", + "type": "gene", + "text": "STUDY DESIGN : Salivary immunoglobulin A levels of each of 20 subjects were determined on 3 occasions : first , while the subject was still smoking ; second , 7 days after cessation of smoking ; third , on the 14th day after cessation .", + "entities": [ + "Salivary immunoglobulin A" + ] + }, + { + "id": "3044", + "type": "gene", + "text": "Documentation of a successful intrauterine fertilization with delivery of a term baby supports the theoretical feasibility of the EP ; however , anovulation incurred by our procedure appears to be the major drawback .", + "entities": [] + }, + { + "id": "3045", + "type": "gene", + "text": "The distinguishing features involved eight amino acid changes , including a single lysine deletion relative to a primate consensus sequence in the first complementary - determing region of V1J1 .", + "entities": [ + "V1J1" + ] + }, + { + "id": "3046", + "type": "gene", + "text": "The 3 ' terminus of the genome can be folded into a tRNA - like secondary structure that has a valine anticodon ; the tRNA - like structure lacks a pseudoknot in the aminoacyl stem , a feature common to both genera of tetraviruses .", + "entities": [] + }, + { + "id": "3047", + "type": "gene", + "text": "Jembrana disease virus ( JDV ) is a newly identified bovine lentivirus that is closely related to the bovine immunodeficiency virus ( BIV ) .", + "entities": [] + }, + { + "id": "3048", + "type": "gene", + "text": "The eating and drinking patterns of pygmy goats fed ad lib and kept on a 12 h light / 12 h dark cycle were recorded and analyzed .", + "entities": [] + }, + { + "id": "3049", + "type": "gene", + "text": "A tobacco homologue ( trolC ) of the rolC gene of the Agrobacterium rhizogenes Ri - plasmid was cloned and sequenced from Nicotiana tabacum L .", + "entities": [ + "trolC", + "rolC gene of the Agrobacterium rhizogenes Ri - plasmid" + ] + }, + { + "id": "3050", + "type": "gene", + "text": "cv .", + "entities": [] + }, + { + "id": "3051", + "type": "gene", + "text": "Recombinant unr acts synergistically with recombinant PTB to stimulate translation dependent on the rhinovirus IRES .", + "entities": [ + "unr", + "PTB" + ] + }, + { + "id": "3052", + "type": "gene", + "text": "Petko , and S .", + "entities": [] + }, + { + "id": "3053", + "type": "gene", + "text": "Studies on the pathogenicity of ECHO 9 ( HILL ) virus and its mutants for suckling mice", + "entities": [] + }, + { + "id": "3054", + "type": "gene", + "text": "In E . coli , CheW mediates the physical coupling of the receptors to the kinase CheA .", + "entities": [ + "CheW", + "CheA" + ] + }, + { + "id": "3055", + "type": "gene", + "text": "Nuclease footprinting revealed that purified glucocorticoid receptor bound at multiple discrete sites within and at the borders of the tandemly repeated sequence motif that defines Sa .", + "entities": [ + "glucocorticoid receptor", + "Sa" + ] + }, + { + "id": "3056", + "type": "gene", + "text": "The maximum induction of ACC - oxidase transcripts occurred at about 6 h after excision , while the maximum enzyme activity was observed at 24 h .", + "entities": [ + "ACC - oxidase transcripts" + ] + }, + { + "id": "3057", + "type": "gene", + "text": "A single amino acid difference in the C - terminal region influences dominant negative activity and receptor dimer formation .", + "entities": [] + }, + { + "id": "3058", + "type": "gene", + "text": "Svensson et al .", + "entities": [] + }, + { + "id": "3059", + "type": "gene", + "text": "Recording of the digital sphygmic activity in the lower extremities with the photoplethysmographic and strain - gauge methods .", + "entities": [] + }, + { + "id": "3060", + "type": "gene", + "text": "CT abnormalities noted in term babies included hemorrhage ( subarachnoid 5 . 8 % , intracerebral 11 . 6 % ) , hypodensity ( mild 23 . 2 % , moderate 11 . 6 % severe 5 . 8 % ) ; hypodensity with hemorrhage 5 . 8 % and cerebral atrophy 5 . 8 % .", + "entities": [] + }, + { + "id": "3061", + "type": "gene", + "text": "Furthermore , a p21X protein lacking the N - terminus of Rex1 was expressed at high levels ; our data indicate that p21X is translated from the 1 . 6 - kb mRNA which is derived primarily from deleted proviruses .", + "entities": [ + "p21X protein", + "Rex1", + "p21X" + ] + }, + { + "id": "3062", + "type": "gene", + "text": "Surface - coil experiments on phantoms and on human calf muscles in vivo are presented .", + "entities": [] + }, + { + "id": "3063", + "type": "gene", + "text": "NERVTRACK contains 4000 anatomical data items arranged in a tree - like manner reflecting structural and functional relationships .", + "entities": [] + }, + { + "id": "3064", + "type": "gene", + "text": "On the basis of histopathological findings , the origin of amyloid appeared to be closely related to the fibroblasts .", + "entities": [] + }, + { + "id": "3065", + "type": "gene", + "text": "Primer extension and mung bean and S1 nuclease mapping indicated multiple transcription initiation sites and were consistent with Northern analyses .", + "entities": [ + "mung bean and S1 nuclease" + ] + }, + { + "id": "3066", + "type": "gene", + "text": "Postglucose serum insulin levels showed no significant correlations with systolic or diastolic blood pressure levels in men , but in female diabetic and non - diabetic subjects significant correlations were found in particular with systolic blood pressure level .", + "entities": [ + "serum insulin" + ] + }, + { + "id": "3067", + "type": "gene", + "text": "Taking into consideration weight and seasonal changes in bone mass , total ( TBBMC ) and regional body bone mineral content were measured in 38 women treated with GnRH agonists for 6 months for endometriosis or leiomyomata .", + "entities": [ + "GnRH" + ] + }, + { + "id": "3068", + "type": "gene", + "text": "Of the patients in each regimen who reached study end points , 17 of 29 ( 59 % ) were in regimen A , 11 of 20 ( 55 % ) were in regimen B , and 28 of 43 ( 65 % ) were in regimen C met the treatment success criterion .", + "entities": [] + }, + { + "id": "3069", + "type": "gene", + "text": "An analysis of the dynamics is performed of exactly solvable models for fragile and strong glasses , exploiting the partitioning of the free - energy landscape in inherent structures .", + "entities": [] + }, + { + "id": "3070", + "type": "gene", + "text": "Antiviral agents .", + "entities": [] + }, + { + "id": "3071", + "type": "gene", + "text": "Spontaneous degradation of atracurium in plasma is the major route of elimination in man and contributes to a short elimination half - life ( approximatively 20 min ) .", + "entities": [] + }, + { + "id": "3072", + "type": "gene", + "text": "Our study cohorts consisted of 15 patients who received SC rIL - 2 at doses of 4 . 8 - 14 . 4 million IU / m2 / day on 5 days per week for a total of 8 weeks , 20 patients who received rIFN - alpha 2b at 3 . 0 - 6 . 0 million U / m2 / day thrice weekly for a total of 6 weeks , and 72 patients who were given SC rIFN - alpha 2b at 6 . 0 million U / m2 / day thrice weekly plus SC rIL - 2 at 14 . 4 - 18 . 0 million IU / m2 / day on days 1 and 2 , followed by 4 . 8 million IU / m2 / day , 5 days per week for 6 consecutive weeks .", + "entities": [ + "rIL - 2", + "rIFN - alpha 2b", + "rIFN - alpha 2b", + "rIL - 2" + ] + }, + { + "id": "3073", + "type": "gene", + "text": "Visual averaged evoked responses and platelet monoamine oxidase in patients suffering from alcoholism .", + "entities": [ + "platelet monoamine oxidase" + ] + }, + { + "id": "3074", + "type": "gene", + "text": "Dimerization of Myf - 5 with the ubiquitously expressed bHLH protein E12 not only increases the affinity for DNA but also stimulates transactivation independently of DNA binding .", + "entities": [ + "Myf - 5", + "E12" + ] + }, + { + "id": "3075", + "type": "gene", + "text": "The increase in amplitudes of the b - wave during the adaptation period was more prominent in lead - exposed subjects than in controls .", + "entities": [] + }, + { + "id": "3076", + "type": "gene", + "text": "Xenopus Ran - binding protein 1 : molecular interactions and effects on nuclear assembly in Xenopus egg extracts .", + "entities": [ + "Xenopus Ran - binding protein 1" + ] + }, + { + "id": "3077", + "type": "gene", + "text": "At rest AFF was significantly higher in UT ( 29 % ) as compared to AT ( 25 % ) and UEA ( 25 % ) .", + "entities": [] + }, + { + "id": "3078", + "type": "gene", + "text": "Chick brain actin depolymerizing factor ( ADF ) is a 19 - kDa protein that severs actin filaments and binds actin monomers .", + "entities": [ + "Chick brain actin depolymerizing factor", + "ADF", + "actin filaments", + "actin monomers" + ] + }, + { + "id": "3079", + "type": "gene", + "text": "Specialized actin tails that propel IEV particles to the periphery and virus - tipped microvilli ( both common in wild - type - infected cells ) were absent in cells infected with vA33delta .", + "entities": [ + "actin" + ] + }, + { + "id": "3080", + "type": "gene", + "text": "Combined immunochemotherapy with cyclophosphamide plus BCG gave a better enhancement of the antitumor effect of the cytostatic than that of the combination of methotrexate plus BCG and cyclophosphamide plus levamisole .", + "entities": [] + }, + { + "id": "3081", + "type": "gene", + "text": "From March 5 through October 26 , 1991 , eight persons were diagnosed with elevated blood lead levels ( BLLs ) at a local hospital and were reported to the notifiable disease surveillance system maintained by the Alabama Department of Public Health ( ADPH ) .", + "entities": [] + }, + { + "id": "3082", + "type": "gene", + "text": "Histochemistry and electron microscopy of acute liver lesions induced by Aflatoxin B1 in ducklings .", + "entities": [] + }, + { + "id": "3083", + "type": "gene", + "text": "To investigate the activity of TCF11 through this selected site , both alone and in the presence of MafG , we have used a transient transfection assay .", + "entities": [ + "TCF11", + "MafG" + ] + }, + { + "id": "3084", + "type": "gene", + "text": "A log - linear dose - response was obtained for the average increase in FEV1 up to 6 h ( AUC0 - 6 h ) and peak FEV1 across the dose range administered by Respimat .", + "entities": [] + }, + { + "id": "3085", + "type": "gene", + "text": "Circularized Ac / Ds transposons : formation , structure and fate .", + "entities": [ + "Ac", + "Ds" + ] + }, + { + "id": "3086", + "type": "gene", + "text": "The increased clearance observed in young infants is in contrast to other opioids .", + "entities": [] + }, + { + "id": "3087", + "type": "gene", + "text": "The extraordinary stability of peptide - - gp96 complexes and the plasticity of the peptide - binding pocket support the proposed relay of diverse peptides to MHC and / or other molecules via molecular recognition .", + "entities": [ + "peptide - - gp96 complexes", + "MHC" + ] + }, + { + "id": "3088", + "type": "gene", + "text": "The utilities measured in our study can be applied directly to quality - of - life determinations in clinical trials of adjuvant IFN alpha - 2b to measure the net benefit of therapy .", + "entities": [ + "IFN alpha - 2b" + ] + }, + { + "id": "3089", + "type": "gene", + "text": "Latexin , a carboxypeptidase A inhibitor , is expressed in a cell type - specific manner in both central and peripheral nervous systems in the rat .", + "entities": [ + "Latexin", + "carboxypeptidase A" + ] + }, + { + "id": "3090", + "type": "gene", + "text": "The results of this study suggest that NF - kappaB activity may be regulated by its interaction with the cell cycle regulatory protein , E2F - 1 .", + "entities": [ + "NF - kappaB", + "E2F - 1" + ] + }, + { + "id": "3091", + "type": "gene", + "text": "Nucleotide sequence analysis of the Pseudomonas putida PpG7 salicylate hydroxylase gene ( nahG ) and its 3 ' - flanking region .", + "entities": [ + "Pseudomonas putida PpG7 salicylate hydroxylase gene", + "nahG" + ] + }, + { + "id": "3092", + "type": "gene", + "text": "The relevance of these elements in conferring anaerobic induction of gpc4 gene expression is discussed .", + "entities": [ + "gpc4 gene" + ] + }, + { + "id": "3093", + "type": "gene", + "text": "A new , flexible fiberoptic ventriculoscope for observation of the ventricles and major cisterns is reported .", + "entities": [] + }, + { + "id": "3094", + "type": "gene", + "text": "Measurements in the LWS p . a .", + "entities": [] + }, + { + "id": "3095", + "type": "gene", + "text": ", LWS lat . and at Ward ' s triangle were made in a total of 100 patients .", + "entities": [] + }, + { + "id": "3096", + "type": "gene", + "text": "IST is not the RNA target ( TAR ) for Tat trans - activation ; however , because it relies entirely on cellular factors for activity , IST may serve to provide abundant RNA targets for Tat trans - activation without a requirement for full - length viral mRNA expression .", + "entities": [ + "IST", + "Tat", + "IST", + "Tat" + ] + }, + { + "id": "3097", + "type": "gene", + "text": "In this study , we have cloned a region that complements the exoenzyme S - deficient phenotype of strain 388 exs1 : : Tn1 , a chromosomal Tn1 insertional mutation .", + "entities": [ + "exoenzyme S", + "exs1", + "Tn1", + "chromosomal Tn1 insertional mutation" + ] + }, + { + "id": "3098", + "type": "gene", + "text": "Copyright 2001 Academic Press .", + "entities": [] + }, + { + "id": "3099", + "type": "gene", + "text": "Skn - 1a lacking the C - terminal region completely lost transactivation ability , irrespective of the promoter tested , and was able to block transactivation by normal Skn - 1a in competition assays .", + "entities": [ + "Skn - 1a", + "Skn - 1a" + ] + }, + { + "id": "3100", + "type": "gene", + "text": "12 healthy women ( age 18 - 38 years ) were examined using the 2 - hour ' s method of passive leg rising ( PLR ) in follicular ( FP ) and luteal ( LP ) phases of normal ovulatory cycle .", + "entities": [] + }, + { + "id": "3101", + "type": "gene", + "text": "Output of 99mTcO - 4 by the parotid gland closely mimicked fluctuations in parotid saliva flow rate .", + "entities": [] + }, + { + "id": "3102", + "type": "gene", + "text": "Addition of sucralfate or De - Nol resulted in increments of gastric HCO3 secretion , reaching about 45 % and 59 % , respectively , of the maximal HCO3 response to 16 , 16 - dimethyl PGE2 ( dmPGE2 ) .", + "entities": [] + }, + { + "id": "3103", + "type": "gene", + "text": "To facilitate the investigation of parameters that govern selective export in adenovirus - infected cells , we constructed a marked human beta - actin minigene under the control of the glucocorticoid - inducible enhancer - promoter of mouse mammary tumor virus and introduced it into the left end of the adenovirus type 5 ( Ad5 ) genome .", + "entities": [ + "beta - actin minigene", + "glucocorticoid - inducible enhancer - promoter" + ] + }, + { + "id": "3104", + "type": "gene", + "text": "Microstructure and conductivity of hierarchical laminate composites .", + "entities": [] + }, + { + "id": "3105", + "type": "gene", + "text": "In contrast , receptor / G protein coupling appeared unaffected by expression of loop 3i domains derived from two receptors coupled to G ( i / o ) proteins ( M2Ach - muscarinic and alpha2A - adrenergic receptors ) .", + "entities": [ + "receptor / G protein", + "G ( i / o ) proteins", + "M2Ach - muscarinic and alpha2A - adrenergic receptors" + ] + }, + { + "id": "3106", + "type": "gene", + "text": "This dependence , however , can be overcome to a large extent by dividing min LVdP / dt by mean aortic pressure .", + "entities": [] + }, + { + "id": "3107", + "type": "gene", + "text": "These adverse effects usually abate with time .", + "entities": [] + }, + { + "id": "3108", + "type": "gene", + "text": "These results indicate that K - glypican is a novel GPI - anchored HSPG involved in embryonic development .", + "entities": [ + "K - glypican", + "GPI - anchored HSPG" + ] + }, + { + "id": "3109", + "type": "gene", + "text": "The mean blood flow in the penile foreskin was estimated to be 15 ml / min / 100 g and it increased to 150 - 200 % after the induction of anesthesia , and then decreased to 72 % at the tip of the created parameatal foreskin flap .", + "entities": [] + }, + { + "id": "3110", + "type": "gene", + "text": "Identification and characterization of specific DNA - binding complexes containing members of the Myc / Max / Mad network of transcriptional regulators .", + "entities": [ + "Myc", + "Max", + "Mad" + ] + }, + { + "id": "3111", + "type": "gene", + "text": "We mapped two overlapping expressed sequence tag clones within a genomic contig on human chromosome 5 , band q31 .", + "entities": [] + }, + { + "id": "3112", + "type": "gene", + "text": "The sequenced cDNA predicts a 704 - amino acid protein 80 % identical to human progelatinase B .", + "entities": [ + "human progelatinase B" + ] + }, + { + "id": "3113", + "type": "gene", + "text": "These results provide direct evidence for differential susceptibility to endonuclease - mediated mRNA decay resulting from the differential affinity of a RNA - binding protein for cis - acting stability determinants .", + "entities": [] + }, + { + "id": "3114", + "type": "gene", + "text": "By using reporter gene constructs , it is shown that upstream sequences of the P1 promoter contain several regions that modulate the expression either positively or negatively .", + "entities": [] + }, + { + "id": "3115", + "type": "gene", + "text": "Analysis of viral mutants in vivo demonstrated that the NFIII / OCT - 1 binding site and a conserved ATF motif were important for efficient viral growth .", + "entities": [ + "NFIII", + "OCT - 1", + "ATF motif" + ] + }, + { + "id": "3116", + "type": "gene", + "text": "Results of a controlled study", + "entities": [] + }, + { + "id": "3117", + "type": "gene", + "text": "These genes may represent interesting targets for new therapeutic strategies .", + "entities": [] + }, + { + "id": "3118", + "type": "gene", + "text": "These HPV16 E6 / E7 cDNAs were cloned under the SV40 enhancer / promoter and the MMTV LTR to examine the activities of ras - collaborative transformation and induction of cellular DNA synthesis , both of which depend on the E7 gene product .", + "entities": [ + "E6", + "E7", + "SV40 enhancer / promoter", + "MMTV LTR", + "ras", + "E7 gene" + ] + }, + { + "id": "3119", + "type": "gene", + "text": "Constitutive protection of E2F recognition sequences in the human thymidine kinase promoter during cell cycle progression .", + "entities": [ + "E2F recognition sequences", + "human thymidine kinase promoter" + ] + }, + { + "id": "3120", + "type": "gene", + "text": "The volume of blood to the flap ranges from 1 to 2 ml / min , collateral circulation to the flap exists , but is negligible , and there is little change in the capillary blood flow as the flap ages .", + "entities": [] + }, + { + "id": "3121", + "type": "gene", + "text": "The possible benefits of LMW heparin ( reduced frequency of bleeding , alleviation of hypertriglyceridemia ) were not , however , apparent , possibly because of the short observation period and the low incidence of hemorrhagic complications in routine dialyses .", + "entities": [] + }, + { + "id": "3122", + "type": "gene", + "text": "ASL - 8123 demonstrated weak competitive beta - adrenoreceptor blocking activity in isolated guinea pig right atria with a pA2 of 3 . 73 + / - 0 . 07 ; no agonist - like activity was observed in this tissue at concentrations of ASL - 8123 from 3 X 10 ( - 5 ) to 1 X 10 ( - 2 ) M .", + "entities": [ + "beta - adrenoreceptor" + ] + }, + { + "id": "3123", + "type": "gene", + "text": "The physical characteristics of these calls vary among species of bat , and variations also exist in the timing and patterns of respiratory muscle recruitment during echolocation .", + "entities": [] + }, + { + "id": "3124", + "type": "gene", + "text": "With regard to the characteristic expression pattern of DJ protein and its conspicuous repeat units possible functional roles are discussed .", + "entities": [ + "DJ protein" + ] + }, + { + "id": "3125", + "type": "gene", + "text": "Cell lines are checked to find out whether they develop tumors in nude mice followed by an analysis of the karyotype .", + "entities": [] + }, + { + "id": "3126", + "type": "gene", + "text": "INTERVENTION ( S ) : Twenty - six hemostasis parameters evaluated repeatedly in patients undergoing IVF - ET .", + "entities": [] + }, + { + "id": "3127", + "type": "gene", + "text": "Genomic clones encompassing the human ETS1 gene were isolated and utilized to define its molecular organization .", + "entities": [ + "human ETS1 gene" + ] + }, + { + "id": "3128", + "type": "gene", + "text": "The present studies compare the biochemical characteristics , Kanagawa hemolysin reactions , and plasmid profiles of 13 patient and 221 environmental isolates of the organism .", + "entities": [ + "hemolysin" + ] + }, + { + "id": "3129", + "type": "gene", + "text": "The Drosophila suppressor of sable gene encodes a polypeptide with regions similar to those of RNA - binding proteins .", + "entities": [ + "Drosophila suppressor of sable gene" + ] + }, + { + "id": "3130", + "type": "gene", + "text": "Although the effects of the calcium supplement or calcium antagonist alone were significant , such hypotensive responses were not optimal or predictable or clearly dose - dependent .", + "entities": [] + }, + { + "id": "3131", + "type": "gene", + "text": "Also , HR21ap as well as HR21Xap are specific in their inhibition of Sp1 binding .", + "entities": [ + "HR21ap", + "HR21Xap", + "Sp1" + ] + }, + { + "id": "3132", + "type": "gene", + "text": "Deletion of both prfA and ponA resulted in extremely slow growth and a reduction in sporulation efficiency .", + "entities": [ + "prfA", + "ponA" + ] + }, + { + "id": "3133", + "type": "gene", + "text": "Does afferent loop syndrome exist ? ] It is the author ' s opinion that diagnosis of the \" adducent loop syndrome \" is unlikely to be correct in patients subjected to Billroth - II gastrectomy .", + "entities": [] + }, + { + "id": "3134", + "type": "gene", + "text": "As an initial step towards the characterization of replicative DNA polymerases of trypanosomes , we have cloned , sequenced and examined the expression of the Trypanosoma ( Trypanozoon ) brucei brucei gene that encodes the DNA polymerase alpha catalytic core ( pol alpha ) .", + "entities": [ + "DNA polymerases of trypanosomes", + "DNA polymerase alpha catalytic core", + "pol alpha" + ] + }, + { + "id": "3135", + "type": "gene", + "text": "Isoform C beta 2 , an unusual form of the bovine catalytic subunit of cAMP - dependent protein kinase .", + "entities": [ + "Isoform C beta 2", + "cAMP - dependent protein kinase" + ] + }, + { + "id": "3136", + "type": "gene", + "text": "The results are given as : flux , number of stars per cm3 , charge of the ions , comparison with other detectors ( plastics , AgCl crystals , LiF ) , energy loss , hit region in the biological objects .", + "entities": [] + }, + { + "id": "3137", + "type": "gene", + "text": "Much evidence indicates that p38 is an activator of MyoD : ( i ) p38 kinase activity is required for the expression of MyoD - responsive genes , ( ii ) enforced induction of p38 stimulates the transcriptional activity of a Gal4 - MyoD fusion protein and allows efficient activation of chromatin - integrated reporters by MyoD , and ( iii ) MyoD - dependent myogenic conversion is reduced in mouse embryonic fibroblasts derived from p38alpha ( - / - ) embryos .", + "entities": [ + "p38", + "MyoD", + "p38 kinase", + "MyoD", + "p38", + "Gal4", + "MyoD", + "MyoD", + "MyoD", + "p38alpha ( - / - )" + ] + }, + { + "id": "3138", + "type": "gene", + "text": "Signal transduction via modulation of phosphorylation after selective inhibition of protein phosphatase ( PP ) 1 and / or PP2A appears to play a role in okadaic acid ( OA ) - mediated effects .", + "entities": [ + "protein phosphatase ( PP ) 1", + "PP2A" + ] + }, + { + "id": "3139", + "type": "gene", + "text": "Although the mechanism of action of ICRF - 159 and 187 has not been clearly defined , it is evident from both preclinical and early clinical studies that these compounds are of interest .", + "entities": [] + }, + { + "id": "3140", + "type": "gene", + "text": "Sequence analysis of a 6 . 3 - kbp genomic EcoRI - fragment of Alcaligenes eutrophus , which was recently identified by using a dihydrolipoamide dehydrogenase - specific DNA probe ( A .", + "entities": [ + "EcoRI", + "dihydrolipoamide dehydrogenase" + ] + }, + { + "id": "3141", + "type": "gene", + "text": "Inhibition of RNA2 translation was selective , with no effect on general cellular translation or translation of BMV RNA1 - encoded replication factor 1a , and was independent of p20 , a cellular antagonist of DED1 function in translation .", + "entities": [ + "RNA2", + "RNA1", + "replication factor 1a", + "p20", + "DED1" + ] + }, + { + "id": "3142", + "type": "gene", + "text": "We have inactivated Krox - 20 by homologous recombination in ES cells and demonstrated that the mutation leads to the deletion of r3 and r5 .", + "entities": [ + "Krox - 20" + ] + }, + { + "id": "3143", + "type": "gene", + "text": "Allergenic activity of allergen extract Ambrosia elatior ( AE ) was tested in fifteen volunteers extremely sensitive to the allergen .", + "entities": [] + }, + { + "id": "3144", + "type": "gene", + "text": "We have studied the biokinetics of BLM labeled with indium - 111 ( In - 111 ) .", + "entities": [] + }, + { + "id": "3145", + "type": "gene", + "text": "To determine which region of SulA is essential for the inhibition of cell division , we constructed a series of N - terminal and C - terminal deletions of SulA and a series of alanine substitution mutants .", + "entities": [ + "SulA", + "SulA" + ] + }, + { + "id": "3146", + "type": "gene", + "text": "Concurrent with ligand - dependent uptake , we now show that the receptor undergoes ligand - induced ubiquitination , suggesting that receptor ubiquitination may function in the ligand - dependent endocytosis of the a - factor receptor as well as in its constitutive endocytosis .", + "entities": [ + "a - factor receptor" + ] + }, + { + "id": "3147", + "type": "gene", + "text": "Plasma Al was obtained during each baseline and drug course .", + "entities": [] + }, + { + "id": "3148", + "type": "gene", + "text": "All patients were evaluable for toxicity and 9 for response .", + "entities": [] + }, + { + "id": "3149", + "type": "gene", + "text": "Glycogen synthesis and catabolism , gluconeogenesis , glycolysis , motility , cell surface properties and adherence are modulated by csrA in Escherichia coli , while the production of several secreted virulence factors , the plant hypersensitive response elicitor HrpN ( Ecc ) and , potentially , other secondary metabolites are regulated by rsmA in Erwinia carotovora .", + "entities": [ + "csrA in Escherichia coli", + "HrpN", + "Ecc", + "rsmA in Erwinia carotovora" + ] + }, + { + "id": "3150", + "type": "gene", + "text": "The topography and trajectories of the commissural fibers of the superior temporal region ( STR ) are studied using the autoradiographic technique .", + "entities": [] + }, + { + "id": "3151", + "type": "gene", + "text": "The statistical analysis consist of the F test followed by Snedecor ' s contrast test .", + "entities": [] + }, + { + "id": "3152", + "type": "gene", + "text": "Two - Channel Kondo Lattice : An Incoherent Metal .", + "entities": [] + }, + { + "id": "3153", + "type": "gene", + "text": "Sequencing of the 16p 11 . 1 / Xq28 duplication breakpoints has revealed the presence of repetitive immunoglobulin - like CAGGG pentamer sequences at or near the paralogy boundaries .", + "entities": [ + "immunoglobulin - like CAGGG pentamer sequences" + ] + }, + { + "id": "3154", + "type": "gene", + "text": "Ultrastructural study of polyarteritis", + "entities": [] + }, + { + "id": "3155", + "type": "gene", + "text": "The Ntl1 gene is present as a unique copy in the diploid N . plumbaginifolia species .", + "entities": [ + "Ntl1 gene" + ] + }, + { + "id": "3156", + "type": "gene", + "text": "With stepwise reductions in flow , the peak ( S ) and trough ( D ) points of the maximum shifted - frequency envelope fell in parallel in a linear fashion until D reached zero .", + "entities": [] + }, + { + "id": "3157", + "type": "gene", + "text": "Thus , a critical question is how HOX proteins select the correct sets of target genes in vivo .", + "entities": [ + "HOX proteins" + ] + }, + { + "id": "3158", + "type": "gene", + "text": "On admission to the ICU , 117 patients ( 61 percent ) had hypomagnesemia ( serum Mg less than 1 . 5 mEq / dl ) , 66 patients ( 34 percent ) had normomagnesemia ( 1 . 5 to 2 . 0 mEq / dl ) , and ten patients ( 5 percent ) had hypermagnesemia ( greater than 2 . 0 mEq / dl ) .", + "entities": [] + }, + { + "id": "3159", + "type": "gene", + "text": "Induction in AP - 1 DNA binding correlates with a concomitant GH trans - activation of c - jun and c - fos genes described previously .", + "entities": [ + "AP - 1", + "GH", + "c - jun", + "c - fos genes" + ] + }, + { + "id": "3160", + "type": "gene", + "text": "Comparison of the cDNA - predicted avian TnIcardiac amino acid sequences with known TnI sequences indicated 1 ) that the presence of an N - terminal extension sequence carrying a dual protein kinase A phosphorylation target site and an adjacent proline - rich segment is an ancient cardiac - specific feature of TnI which has been conserved since the bird / mammal divergence , 2 ) that features of the near - N - terminal troponin C ( TnC ) - binding site sequence suggest isoform - specific adaptation of TnI and TnC , and 3 ) that the avian TnIcardiac internal actin / TnC - binding , actomyosin - inhibitory , domain shows significant sequence divergence from mammalian TnIcardiac sequences , including the absence of a protein kinase C target site which is a cardiac - specific feature of TnI in mammals .", + "entities": [ + "avian TnIcardiac amino acid sequences", + "TnI sequences", + "protein kinase A", + "TnI", + "troponin C", + "TnC", + "TnI", + "TnC", + "TnIcardiac", + "actin / TnC - binding , actomyosin - inhibitory , domain", + "mammalian TnIcardiac sequences", + "protein kinase C", + "TnI" + ] + }, + { + "id": "3161", + "type": "gene", + "text": "Male Japanese quail were chronically exposed to 5000 ppm manganese ( Mn ) as particulate manganese oxide ( Mn3O4 ) in their diet from hatching to 75 days of age .", + "entities": [] + }, + { + "id": "3162", + "type": "gene", + "text": "The 3 - hour test iodine ( I - 132 ) uptake by the thyroid in children with growth deficiency", + "entities": [] + }, + { + "id": "3163", + "type": "gene", + "text": "Although Pho85 is not essential for viability , Pcl1 , 2 - Pho85 kinase complexes become essential for Start in the absence of Cln1 , 2 - Cdc28 kinases .", + "entities": [ + "Pho85", + "Pcl1 , 2", + "Pho85", + "Cln1 , 2", + "Cdc28" + ] + }, + { + "id": "3164", + "type": "gene", + "text": "Correlation coefficients between the reference methods and NIT were > or = 0 . 95 for water , fat , crude protein and connective - tissue - protein frei meat protein , and > or = 0 . 86 for connective - tissue - protein .", + "entities": [] + }, + { + "id": "3165", + "type": "gene", + "text": "Applications of three - dimensional analysis to the auditory P300 .", + "entities": [] + }, + { + "id": "3166", + "type": "gene", + "text": "Human brain cDNA library screening and 5 ' rapid amplification of cDNA ends yielded full - length DENTT cDNA containing an 1899 - bp open reading frame encoding a predicted 633 - amino - acid protein with four potential nuclear localization signals ( NLSs ) and two coiled - coil regions .", + "entities": [ + "full - length DENTT cDNA" + ] + }, + { + "id": "3167", + "type": "gene", + "text": "Corticosteroid therapy is known to be hazardous in patients with occult infection but the mechanism by which the host parasite relationship is altered by steroids is not known . We have used an intestinal protozoal parasite , Giardia muris , to examine the effects of corticosteroids on the number of parasites in the intestine in the course of a primary infection .", + "entities": [] + }, + { + "id": "3168", + "type": "gene", + "text": "Transfer also correlated inversely with gastric juice pH ( r = - 0 . 619 , P < 0 . 02 ) .", + "entities": [] + }, + { + "id": "3169", + "type": "gene", + "text": "The rrd1 , 2delta mutant was partially rescued by inactivation of HOG1 or PBS2 , suggesting an interaction between the RRD genes and the Hog1p signal transduction pathway .", + "entities": [ + "rrd1 , 2delta mutant", + "HOG1", + "PBS2", + "RRD genes", + "Hog1p signal transduction pathway" + ] + }, + { + "id": "3170", + "type": "gene", + "text": "Sci .", + "entities": [] + }, + { + "id": "3171", + "type": "gene", + "text": "One chimpanzee reliably selected the larger numeral 4 during testing with a nonadjacent pair ( 2 - 4 ) , and 2 chimps showed no preference .", + "entities": [] + }, + { + "id": "3172", + "type": "gene", + "text": "At 4 wk however , tumor relapse was noted in 6 of 7 group 4 responders , 10 of 12 in group 5 , 13 of 16 in group 7 , but only 4 of 19 group 8 responders ( p less than . 001 group 8 versus 4 , 5 , 7 ) .", + "entities": [] + }, + { + "id": "3173", + "type": "gene", + "text": "Three cases of primary signet - ring cell carcinoma of the rectum are described .", + "entities": [] + }, + { + "id": "3174", + "type": "gene", + "text": "Double - blind , placebo - controlled trial .", + "entities": [] + }, + { + "id": "3175", + "type": "gene", + "text": "( GUT ) Sera of 30 montoux negative healthy adults ( age / sex matched ) were taken as control by detecting IgG anti bodies to A60 antigen .", + "entities": [ + "IgG anti bodies", + "A60 antigen" + ] + }, + { + "id": "3176", + "type": "gene", + "text": "By Caveman .", + "entities": [] + }, + { + "id": "3177", + "type": "gene", + "text": "Porcelain to dentin bond strength with a dentin adhesive .", + "entities": [] + }, + { + "id": "3178", + "type": "gene", + "text": "Minor initiation sites were found at positions - 128 , - 111 , - 91 , and - 74 .", + "entities": [] + }, + { + "id": "3179", + "type": "gene", + "text": "The RAD18 gene open reading frame encodes a protein of 487 amino acids , with a calculated molecular weight of 55 , 512 .", + "entities": [ + "RAD18 gene open reading frame" + ] + }, + { + "id": "3180", + "type": "gene", + "text": "Of the three known C / EBP family inhibitors , Ig / EBP , LIP and CHOP - 10 , only Ig / EBP is ubiquitously expressed .", + "entities": [ + "C / EBP family", + "Ig / EBP", + "LIP", + "CHOP - 10", + "Ig / EBP" + ] + }, + { + "id": "3181", + "type": "gene", + "text": "The nerve growth factor beta gene ( NGFB ) belongs to a conserved syntenic group on human chromosome 1 and mouse Chromosome 3 .", + "entities": [ + "nerve growth factor beta gene", + "NGFB" + ] + }, + { + "id": "3182", + "type": "gene", + "text": "Pharmacologic properties of serotonergic agents and antidepressant drugs .", + "entities": [] + }, + { + "id": "3183", + "type": "gene", + "text": "Sixty - one cases of cholera , all caused by V . cholerae O1 , were reported .", + "entities": [] + }, + { + "id": "3184", + "type": "gene", + "text": "Thromboxane B2 increased ( 97 + / - 105 versus 40 + / - 26 pg / ml ) and was significantly higher during heparin free hemodialysis than during hemodialysis with heparin ( p = 0 . 01 , Wilcoxon matched pairs signed rank test ) .", + "entities": [] + }, + { + "id": "3185", + "type": "gene", + "text": "Different cortical malformations were produced in rats by a single dose of X - rays ( 200 cGy ) given on different days during gestation .", + "entities": [] + }, + { + "id": "3186", + "type": "gene", + "text": "In this report we studied the role of protein - tyrosine phosphatase SHP - 2 in ErbB - mediated activation of mitogen - activated protein kinase ( MAPK ) by overexpressing SHP - 2 mutants in COS - 7 cells .", + "entities": [ + "SHP - 2", + "ErbB", + "mitogen - activated protein kinase", + "MAPK", + "SHP - 2 mutants" + ] + }, + { + "id": "3187", + "type": "gene", + "text": "To further investigate the nature of the site specificity a set of deletion mutants of the 160 bp sequence were analysed .", + "entities": [] + }, + { + "id": "3188", + "type": "gene", + "text": "Isolation and characterization of a cDNA encoding a putative cytokine which is induced by stimulation via the CD2 structure on human T lymphocytes .", + "entities": [ + "CD2 structure" + ] + }, + { + "id": "3189", + "type": "gene", + "text": "GTPase activating specificity of RGS12 and binding specificity of an alternatively spliced PDZ ( PSD - 95 / Dlg / ZO - 1 ) domain .", + "entities": [ + "GTPase", + "RGS12", + "PDZ", + "PSD - 95", + "Dlg", + "ZO - 1" + ] + }, + { + "id": "3190", + "type": "gene", + "text": "Pentobarbital ( 1 , 3 , 10 , and 17 . 5 mg / kg ) was also tested in combination with rate - decreasing doses of normeperidine ( 17 . 5 mg / kg ) , anileridine ( 10 mg / kg ) , alphaprodine ( 10 mg / kg ) , and fentanyl ( 0 . 3 mg / kg ) .", + "entities": [] + }, + { + "id": "3191", + "type": "gene", + "text": "PURPOSE : To determine the effects of hypercholesterolemia and atherosclerosis - induced chronic cavernosal arterial insufficiency on cavernosal smooth muscle tone , nitric oxide synthase ( NOS ) activity and cavernosal tissue synthesis of constrictor eicosanoids .", + "entities": [ + "nitric oxide synthase", + "NOS" + ] + }, + { + "id": "3192", + "type": "gene", + "text": "Serum ascorbic acid had an inverse and the strongest association with systolic blood pressure among the risk factors including blood pressure , total cholesterol , triglyceride , gamma - GTP and obesity .", + "entities": [ + "gamma - GTP" + ] + }, + { + "id": "3193", + "type": "gene", + "text": "Similarly , overexpression of increasing concentration of COUP - TFI , but not COUP - TFI delta35 , can squelch the silencing activity of the unliganded TRbeta .", + "entities": [ + "COUP - TFI", + "COUP - TFI delta35", + "TRbeta" + ] + }, + { + "id": "3194", + "type": "gene", + "text": "Transcervical amnioinfusion .", + "entities": [] + }, + { + "id": "3195", + "type": "gene", + "text": "Although ANP induced systemic capillary filtration , in the calf , filtration was reduced with ANP .", + "entities": [ + "ANP", + "ANP" + ] + }, + { + "id": "3196", + "type": "gene", + "text": "These findings show that EBP50 is a physiologically relevant ezrin binding protein .", + "entities": [ + "EBP50", + "ezrin binding protein" + ] + }, + { + "id": "3197", + "type": "gene", + "text": "The promoter of the rat pgp2 / mdr1b gene has a GC - rich region ( pgp2GC ) that is highly conserved in mdr genes and contains an consensus Sp1 site .", + "entities": [ + "pgp2", + "mdr1b", + "pgp2GC", + "mdr genes", + "Sp1 site" + ] + }, + { + "id": "3198", + "type": "gene", + "text": "The rate - limiting step for telomerase activity seems to be the expression of the catalytic subunit of the enzyme , encoded by the human telomerase reverse transcriptase ( hTERT ) gene .", + "entities": [ + "telomerase", + "human telomerase reverse transcriptase", + "hTERT" + ] + }, + { + "id": "3199", + "type": "gene", + "text": "Cerebral vasculitis secondary to Crohn ' s disease seems to be a very rare phenomenon .", + "entities": [] + }, + { + "id": "3200", + "type": "gene", + "text": "The predicted protein products of ORFs N2417 and N2403 present similarities with domains from proteins of other organisms : the Candida maltosa cycloheximide - resistance protein , the human interleukin enhancer - binding factor ( ILF - 2 ) .", + "entities": [ + "ORFs N2417", + "N2403", + "cycloheximide - resistance protein", + "interleukin enhancer - binding factor", + "ILF - 2" + ] + }, + { + "id": "3201", + "type": "gene", + "text": "Basal plasma AVP levels and AVP release after postural change were assessed , and plasma NPY levels were measured in the same samples .", + "entities": [ + "AVP", + "AVP", + "NPY" + ] + }, + { + "id": "3202", + "type": "gene", + "text": "SSeCKS ( pronounced essex ) encodes a major protein kinase C substrate , the expression of which is down - regulated in src - and ras - transformed rodent fibroblasts but not in raf - transformed rodent fibroblasts ( X .", + "entities": [ + "SSeCKS", + "protein kinase C", + "src", + "ras" + ] + }, + { + "id": "3203", + "type": "gene", + "text": "Aspirin causes peptic ulcers predominately by reducing gastric mucosal cyclooxygenase ( COX ) activity and prostaglandin synthesis .", + "entities": [ + "gastric mucosal cyclooxygenase", + "COX" + ] + }, + { + "id": "3204", + "type": "gene", + "text": "With current methodology beta - 2 transferrin does not appear to be a reliable clinical marker for perilymph in the operative setting .", + "entities": [ + "beta - 2 transferrin" + ] + }, + { + "id": "3205", + "type": "gene", + "text": "This is the first description , to our knowledge , of regulatory elements that control expression of a gene encoding a B7 costimulatory molecule .", + "entities": [ + "B7 costimulatory molecule" + ] + }, + { + "id": "3206", + "type": "gene", + "text": "Genitography in intersexual states .", + "entities": [] + }, + { + "id": "3207", + "type": "gene", + "text": "In each compartment O2 is removed by the tissues as a chemical reaction takes place between O2 and oxyhemoglobin ( HbO2 ) .", + "entities": [ + "oxyhemoglobin", + "HbO2" + ] + }, + { + "id": "3208", + "type": "gene", + "text": "Comparison of beta 2 - microglobulin removal using the same polysulphone membrane for haemodialysis and haemofiltration shows that beta 2 - microglobulin is more effectively removed by convection than by diffusion when both treatment modes are matched for blood flow and urea clearance .", + "entities": [ + "beta 2 - microglobulin", + "beta 2 - microglobulin" + ] + }, + { + "id": "3209", + "type": "gene", + "text": "The osmotic diuretic mannitol was administered to 21 patients .", + "entities": [] + }, + { + "id": "3210", + "type": "gene", + "text": "In patients , the effect of CCK - PZ on the movement of the terminal part of the bile duct was measured with a pressure sensor using a duodenofiberscope .", + "entities": [ + "CCK", + "PZ" + ] + }, + { + "id": "3211", + "type": "gene", + "text": "In contrast , the neu proto - oncogene did not show kinase activity or transforming properties when expressed at similar levels in NIH 3T3 cells . ( ABSTRACT TRUNCATED AT 250 WORDS )", + "entities": [ + "neu proto - oncogene" + ] + }, + { + "id": "3212", + "type": "gene", + "text": "Plasma thrombomodulin : a marker for microvascular complications in diabetes mellitus .", + "entities": [ + "thrombomodulin" + ] + }, + { + "id": "3213", + "type": "gene", + "text": "The sequence of the putative RBP1 protein contains two copies of an RNA recognition motif , two glutamine stretches , an asparagine - rich region , a methionine - rich region , and two long potential alpha - helixes .", + "entities": [ + "RBP1 protein" + ] + }, + { + "id": "3214", + "type": "gene", + "text": "During this time , the patients all had the characteristic plasma thyroid hormone changes associated with amiodarone therapy , i . e . increased T4 , free T4 , and rT3 and decreased T3 , while remaining clinically euthyroid .", + "entities": [] + }, + { + "id": "3215", + "type": "gene", + "text": "Nine strains were subtyped as Camp . jejuni subsp . jejuni biotype II and the remaining ones as biotype I .", + "entities": [] + }, + { + "id": "3216", + "type": "gene", + "text": "J .", + "entities": [] + }, + { + "id": "3217", + "type": "gene", + "text": "However , although deletion of Fp1 in the hCRBP1 gene yielded increased CAT activity , pointing toward a negative regulatory function exerted by this element , its insertion upstream of the p12 basal promoter results in an impressive positive stimulation of CAT gene expression .", + "entities": [ + "Fp1", + "hCRBP1 gene", + "CAT", + "p12 basal promoter", + "CAT gene" + ] + }, + { + "id": "3218", + "type": "gene", + "text": "The in vitro relaxivity of the complex is 16 . 24 s ( - 1 ) mM ( - 1 ) .", + "entities": [] + }, + { + "id": "3219", + "type": "gene", + "text": "Phylogenetic analyses of 19 amino acid sequences of 6 related protein types indicate that actin - associated proteins related to gelsolin are monophyletic to a common ancestor and include flightless proteins .", + "entities": [ + "actin", + "gelsolin", + "flightless proteins" + ] + }, + { + "id": "3220", + "type": "gene", + "text": "This report has reviewed some of the reasons for treatment failures and has presented a philosophy for their management .", + "entities": [] + }, + { + "id": "3221", + "type": "gene", + "text": "Specimen mass reduction increased with irradiance from 19 to 72 % of the initial mass for 9 - - 31 W / cm ( 2 ) , respectively .", + "entities": [] + }, + { + "id": "3222", + "type": "gene", + "text": "Intensive synthesis of PNA in the cells of microvascular wall evidenced of their high functional activity , and the synthesis of DNA in them showed their ability for proliferation , i . g . - - for growth .", + "entities": [ + "PNA" + ] + }, + { + "id": "3223", + "type": "gene", + "text": "Qualitatively , the results are similar for the two species : Both rhesus monkey and man have photopic and scotopic branches , which cross at approximately the same time in the dark and at approximately the same background luminance .", + "entities": [] + }, + { + "id": "3224", + "type": "gene", + "text": "There was no correlation between serum LH and chronological or bone age in this age group , which suggests that the correlation found is not due to age - related parallel phenomena .", + "entities": [ + "serum LH" + ] + }, + { + "id": "3225", + "type": "gene", + "text": "CONCLUSIONS : A comparison of the LysU crystal structure with the structures of seryl - and aspartyl - tRNA synthetases enables a conserved core to be identified .", + "entities": [ + "LysU", + "seryl - and aspartyl - tRNA synthetases" + ] + }, + { + "id": "3226", + "type": "gene", + "text": "Three patients received additional cycles of 5 - fluorouracil + / - leucovorin as maintenance chemotherapy . RESULTS : Thirty males and 21 females with a median age of 55 years ( range 31 - - 73 years ) were treated .", + "entities": [] + }, + { + "id": "3227", + "type": "gene", + "text": "Effects of activating blood circulation to remove blood stasis on barrier action of gastric wall in chronic atrophic gastritis", + "entities": [] + }, + { + "id": "3228", + "type": "gene", + "text": "Consequently , it is not known how knee loading changes following ACL transection , and how it contributes to cartilage degeneration .", + "entities": [] + }, + { + "id": "3229", + "type": "gene", + "text": "Lung and multi - system damage were early indicators of poor outcome in severe non - fatal disease .", + "entities": [] + }, + { + "id": "3230", + "type": "gene", + "text": "The experiments show that it is the micromilieu of the alveoli and the condition of the AM ( certain physiological activation states , such as phagocytic activity ) that essentially determine the degree of recovery .", + "entities": [] + }, + { + "id": "3231", + "type": "gene", + "text": "RESULTS : The introduction of the PAIP resulted in a significant ( p < 0 . 001 ) reduction in contaminating WBCs ( median , 30 , 000 ) from the numbers seen with FIP ( median , 2 , 300 , 000 ) while maintaining the separation efficacy ( 47 % ) and separation time .", + "entities": [] + }, + { + "id": "3232", + "type": "gene", + "text": "We also present evidence that human HYAL1 is identical to an uncharacterized gene positionally cloned by others from chromosome 3p21 . 3 that is homozygously deleted in several small - cell lung carcinoma cell lines .", + "entities": [ + "human HYAL1" + ] + }, + { + "id": "3233", + "type": "gene", + "text": "In these cells , E2 proteins had little or no stimulatory effect on the transcriptional activity of the HPV - 11 enhancer - SV40 promoter .", + "entities": [ + "E2 proteins", + "HPV - 11 enhancer", + "SV40 promoter" + ] + }, + { + "id": "3234", + "type": "gene", + "text": "The introduction of hARF4 to the cells maintained the balance between cytosolic and membrane - associated Sec7p pools .", + "entities": [ + "hARF4", + "Sec7p" + ] + }, + { + "id": "3235", + "type": "gene", + "text": "Determination of an RNA structure involved in splicing inhibition of a muscle - specific exon .", + "entities": [] + }, + { + "id": "3236", + "type": "gene", + "text": "Bound - exciton transfer and photoluminescence undulation spectra for acceptors in ZnTe .", + "entities": [] + }, + { + "id": "3237", + "type": "gene", + "text": "The initial inpatient experience for individuals with HIV - related TB may be pivotal to the acceptance of and participation in ongoing TB care .", + "entities": [] + }, + { + "id": "3238", + "type": "gene", + "text": "Sucrose - specific regulation of scrB was also lost upon deletion of 4 bp of a palindromic sequence ( OB ) covering positions + 6 to + 21 downstream of the scrB transcriptional start site .", + "entities": [ + "scrB", + "scrB" + ] + }, + { + "id": "3239", + "type": "gene", + "text": "Adrenergic nerve function , noradrenaline level and noradrenaline uptake in cat nictitating membrane after reserpine treatment .", + "entities": [] + }, + { + "id": "3240", + "type": "gene", + "text": "Thus , the PCE binds a Pbx dimer partner that behaves unlike Class I Hox proteins .", + "entities": [ + "PCE", + "Pbx dimer partner", + "Class I Hox proteins" + ] + }, + { + "id": "3241", + "type": "gene", + "text": "In addition to the bZIP protein Opaque2 ( O2 ) , there are other maize endosperm nuclear proteins that recognize the O2 box in 22 kDa zein gene promoters .", + "entities": [ + "bZIP protein Opaque2", + "O2", + "O2 box", + "zein" + ] + }, + { + "id": "3242", + "type": "gene", + "text": "Calcitonin simultaneously regulates both periosteal hyperostosis and trabecular osteopenia in the spinal hyperostotic mouse ( twy / twy ) in vivo .", + "entities": [ + "Calcitonin", + "twy", + "twy" + ] + }, + { + "id": "3243", + "type": "gene", + "text": "A poor correlation was found between a mildly - atypical ( inflammatory ) cytological result ( class 2 ) and a benign histological diagnosis : 48 % of class - 2 smears were diagnosed histologically as dysplasia or worse .", + "entities": [] + }, + { + "id": "3244", + "type": "gene", + "text": "DAF16 is known to be a component of a signaling pathway that has been partially dissected genetically and includes homologues of the insulin / IGF - 1 receptor , PtdIns 3 - kinase and PKB .", + "entities": [ + "DAF16", + "insulin", + "IGF - 1 receptor", + "PtdIns 3 - kinase", + "PKB" + ] + }, + { + "id": "3245", + "type": "gene", + "text": "A herpesvirus proteinase activity has been identified and partially characterized by using the cloned enzyme and substrate genes in transient transfection assays .", + "entities": [] + }, + { + "id": "3246", + "type": "gene", + "text": "Insulin - stimulated glucose transport in adipocytes is mediated by the insulin receptor .", + "entities": [ + "Insulin", + "insulin receptor" + ] + }, + { + "id": "3247", + "type": "gene", + "text": "In the work reported here , we used peptide mapping , mass spectrometry , and site - directed mutagenesis to identify two sets of pAP phosphorylation sites .", + "entities": [ + "pAP" + ] + }, + { + "id": "3248", + "type": "gene", + "text": "Structural and evolutionary studies on sterol 14 - demethylase P450 ( CYP51 ) , the most conserved P450 monooxygenase : I .", + "entities": [ + "sterol 14 - demethylase P450", + "CYP51", + "P450 monooxygenase" + ] + }, + { + "id": "3249", + "type": "gene", + "text": "All patients received VCR 1 . 0 mg / m2 weekly for 6 weeks with dose modification for neurotoxicity .", + "entities": [] + }, + { + "id": "3250", + "type": "gene", + "text": "AB004534 .", + "entities": [ + "AB004534" + ] + }, + { + "id": "3251", + "type": "gene", + "text": "SNAP - 23 plays an important role in the regulation of vesicle trafficking in mammalian cells .", + "entities": [ + "SNAP - 23" + ] + }, + { + "id": "3252", + "type": "gene", + "text": "Major clinical symptoms of the disease were defined in this group of patients .", + "entities": [] + }, + { + "id": "3253", + "type": "gene", + "text": "In the past decade , there have been enormous advances in the use of Bayesian methodology for analysis of epidemiologic data , and there are now many practical advantages to the Bayesian approach .", + "entities": [] + }, + { + "id": "3254", + "type": "gene", + "text": "In view of the short t1 / 2 , we used three doses / day .", + "entities": [] + }, + { + "id": "3255", + "type": "gene", + "text": "The mechanism of action is explored in some detail , specifically as it relates to reticuloendothelial system ( RES ) Fc receptor blockade and suppression of antiplatelet antibody synthesis .", + "entities": [ + "Fc receptor" + ] + }, + { + "id": "3256", + "type": "gene", + "text": "Sequence comparisons have shown that Aps1p is more similar to the sigma subunit of the Golgi - localized mammalian AP - 1 complex than Aps2p , which is more related to the plasma membrane AP - 2 sigma subunit .", + "entities": [ + "Aps1p", + "AP - 1 complex", + "Aps2p", + "AP - 2 sigma" + ] + }, + { + "id": "3257", + "type": "gene", + "text": "Their use established that the BrAAP activity catalyzed both a postproline and a postglutamate cleavage and therefore has a broader specificity than previously recognized .", + "entities": [] + }, + { + "id": "3258", + "type": "gene", + "text": "In addition , these cells contained one , two , or multiple nuclei indicative of a G2 / M delay in nuclear division and also a defect in cytokinesis and / or cell separation .", + "entities": [] + }, + { + "id": "3259", + "type": "gene", + "text": "When statistically analyzed in various subgroupings , the obtained average sedimentation coefficients and polydispersity profiles supported the following conclusions : ( a ) loss of proteoglycan aggregation and sedimentability is confirmed to be a primary sign of cartilage matrix degradation ; ( b ) higher S values for proteoglycans of the high weight ( HW ) - bearing areas and lower values for those of the low weight ( LW ) - bearing areas were a typical finding in normal cartilage samples ; ( c ) inversion of this pattern was indicative of matrix degradation , suggesting that the HW regions are more affected than the LW - bearing areas ; ( d ) the average S value distribution across cartilage thickness tended to resemble the corresponding proteoglycan content versus distance from articular surface ; and ( e ) the deepest cartilage layer had , in most cases , the smallest amount of aggregates while the highest average sedimentability was observed at the middle zone of the normal samples .", + "entities": [] + }, + { + "id": "3260", + "type": "gene", + "text": "The Mig1 repressor is a zinc finger protein that mediates glucose repression in yeast .", + "entities": [ + "Mig1 repressor", + "zinc finger protein" + ] + }, + { + "id": "3261", + "type": "gene", + "text": "Seventy - one supplementary doses of vecuronium were used for muscle relaxation during a 22 - h - long NLA II anaesthesia .", + "entities": [] + }, + { + "id": "3262", + "type": "gene", + "text": "The nucleotide sequences of these genes differ at only nine positions , resulting in three amino acid differences .", + "entities": [] + }, + { + "id": "3263", + "type": "gene", + "text": "In mammalian tissue culture cells , overexpression of any of the four mouse deltex homologs suppressed the transcriptional activity of E47 , a basic helix - loop - helix ( bHLH ) protein , in a manner similar to suppression by an activated form of human Notch1 or human DTX1 .", + "entities": [ + "E47", + "basic helix - loop - helix ( bHLH ) protein", + "human Notch1", + "human DTX1" + ] + }, + { + "id": "3264", + "type": "gene", + "text": "We identify the \" M region \" of the muscle - specific Xenopus cardiac actin gene promoter from - 282 to - 348 as necessary for the embryonic expression of a cardiac actin - beta - globin reporter gene injected into fertilized eggs .", + "entities": [ + "muscle - specific Xenopus cardiac actin gene promoter", + "actin", + "beta - globin" + ] + }, + { + "id": "3265", + "type": "gene", + "text": "Employing fluorescence spectroscopy and circular dichroism , we showed that the binding of Ca2 + to ALG - 2 induced significant conformational changes in both the N - terminal and C - terminal domains of the protein .", + "entities": [ + "ALG - 2" + ] + }, + { + "id": "3266", + "type": "gene", + "text": "INF - alpha therapy has been a major development in the treatment of CML .", + "entities": [ + "INF - alpha" + ] + }, + { + "id": "3267", + "type": "gene", + "text": "There was no difference in plasma concentrations of PGI2 ( figure 4 ) and TxA2 in patients with normal blood pressure , mild preeclampsia and hypotension , whereas in severe preeclampsia , the plasma concentration of PGI2 was significantly lower ( p < 0 . 001 ) and of TxA2 significantly higher ( p < 0 . 001 ) .", + "entities": [] + }, + { + "id": "3268", + "type": "gene", + "text": "This plus the reduced phosphorylation of p27 by MAPK enhanced the stability of p27 that associated with nuclear Cdk2 at high stoichiometry and inhibited its kinase activity .", + "entities": [ + "p27", + "MAPK", + "p27", + "nuclear Cdk2" + ] + }, + { + "id": "3269", + "type": "gene", + "text": "G . , and Hyde , C .", + "entities": [] + }, + { + "id": "3270", + "type": "gene", + "text": "Antenatal diagnosis of haematological disorders - - ' 1978 ' .", + "entities": [] + }, + { + "id": "3271", + "type": "gene", + "text": "Expression of a dominant negative Smad2 significantly reduces the level of luciferase reporter activity induced by nodal treatment .", + "entities": [ + "dominant negative Smad2", + "luciferase reporter" + ] + }, + { + "id": "3272", + "type": "gene", + "text": "Two hundred sixty - four patients scheduled for DCBM were randomized to receive intravenously geG 0 . 25 mg ( geG - 25 ) , or geG 0 . 5 mg ( geG - 50 ) , or HBB 20 mg as hypotonic agent .", + "entities": [] + }, + { + "id": "3273", + "type": "gene", + "text": "Retrogradely labelled neurons significantly prevailed in the ipsilateral substantia nigra pars compacta .", + "entities": [] + }, + { + "id": "3274", + "type": "gene", + "text": "Chronic hepatitis B in adopted Romanian children .", + "entities": [] + }, + { + "id": "3275", + "type": "gene", + "text": "Saunders Company .", + "entities": [] + }, + { + "id": "3276", + "type": "gene", + "text": "Regions of the translated open reading frames of cobA and the third intron of the cob gene in yeast show high amino acid homology .", + "entities": [ + "cobA", + "cob gene in yeast" + ] + }, + { + "id": "3277", + "type": "gene", + "text": "Thus , patients with metastatic melanoma are not tolerant to gp100 Ag based on the detection of CD8 + T cells specific for multiple HLA - A * 0201 - restricted , gp100 - derived epitopes .", + "entities": [ + "gp100 Ag", + "CD8 +", + "HLA - A * 0201", + "gp100" + ] + }, + { + "id": "3278", + "type": "gene", + "text": "The predicted amino acid sequence exhibited 70 % identity to that of Bacillus stearothermophilus TyrTS and 55 % identity to that of E . coli TyrTS , while identity to a second cryptic B . subtilis TyrTS gene , designated tyrZ , was only 27 % .", + "entities": [ + "Bacillus stearothermophilus TyrTS", + "E . coli TyrTS", + "B . subtilis TyrTS gene", + "tyrZ" + ] + }, + { + "id": "3279", + "type": "gene", + "text": "Investigated the reliability , validity and dimensionality of scores obtained by acute psychiatric inpatients ( N = 120 ) on the Michigan Alcoholism Screening Test adapted to assess lifetime and current symptomatology .", + "entities": [] + }, + { + "id": "3280", + "type": "gene", + "text": "Consistent with this finding , wild - type SAGA inhibits TBP binding to the HIS3 promoter in vitro , while SAGA lacking Spt3 or Spt8 is not inhibitory .", + "entities": [ + "wild - type SAGA", + "TBP", + "HIS3 promoter", + "SAGA", + "Spt3", + "Spt8" + ] + }, + { + "id": "3281", + "type": "gene", + "text": "METHODS : 109 suspected cases with SS underwent the biopsies .", + "entities": [] + }, + { + "id": "3282", + "type": "gene", + "text": "The purpose of this investigation was to describe a new formulation of silver sulfadiazine in a water soluble gel , poloxamer 188 .", + "entities": [] + }, + { + "id": "3283", + "type": "gene", + "text": "In addition , the affinities of CBF2 for binding to the LMP - 1 , LMP - 2 , and CD23 promoters were also measured .", + "entities": [ + "CBF2", + "LMP - 1", + "LMP - 2", + "CD23 promoters" + ] + }, + { + "id": "3284", + "type": "gene", + "text": "Mutations in the alpha - amanitin conserved domain of the largest subunit of yeast RNA polymerase III affect pausing , RNA cleavage and transcriptional transitions .", + "entities": [ + "alpha - amanitin", + "yeast RNA polymerase III" + ] + }, + { + "id": "3285", + "type": "gene", + "text": "Several lines of evidence presented here suggest that PKC - zeta plays a role in alpha 2 integrin gene expression .", + "entities": [ + "PKC - zeta", + "alpha 2 integrin gene" + ] + }, + { + "id": "3286", + "type": "gene", + "text": "The 319 base pair region immediately upstream of the CAP site is characterized by the lack of a proximal TATA box and the presence of sequences similar to GC boxes , CACCC boxes , CCAAT boxes , activator protein 2 ( Ap - 2 ) sites , partial glucocorticoid response elements ( GREs ) , and partial cyclic AMP response elements ( CREs ) .", + "entities": [ + "activator protein 2", + "Ap - 2" + ] + }, + { + "id": "3287", + "type": "gene", + "text": "Most of the patients had locally advanced lesions ( 63 T3 - 4 : 91 . 5 % ) according to the adopted TNM system ( Lederman - Gadeberg , Sisson - Jesse ) .", + "entities": [] + }, + { + "id": "3288", + "type": "gene", + "text": "The peak velocities of the atrial systolic waves of the transmitral and pulmonary venous flow velocities ( A and PVA , respectively ) and first systolic wave ( PVS1 ) of pulmonary venous flow , durations of both atrial systolic waves , and amplitude of interatrial septal motion during atrial systole increased significantly ten days after cardioversion compared with those measured within a day of cardioversion in all patients except the 5 patients with dilated cardiomyopathy .", + "entities": [] + }, + { + "id": "3289", + "type": "gene", + "text": "The isoform , designated HDAC9a , is 132 aa shorter at the C terminus than HDAC9 .", + "entities": [ + "HDAC9a", + "HDAC9" + ] + }, + { + "id": "3290", + "type": "gene", + "text": "Twelve out of 43 renal failure patients had troponin I 0 . 13 - 0 . 9 microg / l using Axsym method and 4 had levels of 0 . 07 - 0 . 13 microg / l using Immuno 1 .", + "entities": [ + "troponin I" + ] + }, + { + "id": "3291", + "type": "gene", + "text": "Tumor cells were focally immunoreactive for neuron - specific enolase , insulin , glucagon and VIP .", + "entities": [ + "neuron - specific enolase", + "insulin", + "glucagon", + "VIP" + ] + }, + { + "id": "3292", + "type": "gene", + "text": "Consistently , activation of c - Jun N - terminal kinase downstream of Rho family GTP - binding proteins was also enhanced when Dbl was tyrosine - phosphorylated .", + "entities": [ + "c - Jun N - terminal kinase", + "Rho family GTP - binding proteins", + "Dbl" + ] + }, + { + "id": "3293", + "type": "gene", + "text": "Expression of the wt1 gene via transient transfection in COS - 1 cells revealed a 52 kDa protein which was immunoprecipitated by both the N - terminal - and C - terminal - specific antisera .", + "entities": [ + "wt1 gene" + ] + }, + { + "id": "3294", + "type": "gene", + "text": "Lymphatics in the aorta of rats treated with a soy - bean oil extract ( lipofundin ) .", + "entities": [] + }, + { + "id": "3295", + "type": "gene", + "text": "Clicking on \" Examples and Explanations of APA Form \" provides a help system with examples of the various sections of a review article , journal article that has one experiment , or journal article that has two or more experiments .", + "entities": [] + }, + { + "id": "3296", + "type": "gene", + "text": "16 subjects were repatch tested to ethylmercury chloride ( EtHgCl ) and to solutions containing EtHgCl mixed with L - cysteine and glutathione , respectively .", + "entities": [] + }, + { + "id": "3297", + "type": "gene", + "text": "Of these proteins , five have previously been shown to be phosphorylated during mitosis ( epithelial - microtubule associated protein - 115 , Oct91 , Elongation factor 1gamma , BRG1 and Ribosomal protein L18A ) , five are related to proteins postulated to have roles in mitosis ( epithelial - microtubule associated protein - 115 , Schizosaccharomyces pombe Cdc5 , innercentrosome protein , BRG1 and the RNA helicase WM6 ) , and nine are related to transcription factors ( BRG1 , negative co - factor 2alpha , Oct91 , S . pombe Cdc5 , HoxD1 , Sox3 , Vent2 , and two isoforms of Xbr1b ) .", + "entities": [ + "epithelial - microtubule associated protein - 115", + "Oct91", + "Elongation factor 1gamma", + "BRG1", + "Ribosomal protein L18A", + "epithelial - microtubule associated protein - 115", + "Schizosaccharomyces pombe Cdc5", + "innercentrosome protein", + "BRG1", + "RNA helicase WM6", + "BRG1", + "negative co - factor 2alpha", + "Oct91", + "Cdc5", + "HoxD1", + "Sox3", + "Vent2", + "Xbr1b" + ] + }, + { + "id": "3298", + "type": "gene", + "text": "To determine if the NF ( H ) promoter can be activated in a tissue specific manner during development transgenic mice containing the promoter region linked to a beta - galactosidase reporter gene were generated .", + "entities": [ + "NF ( H ) promoter", + "beta - galactosidase reporter gene" + ] + }, + { + "id": "3299", + "type": "gene", + "text": "Tcn1p / Crz1p , a calcineurin - dependent transcription factor that differentially regulates gene expression in Saccharomyces cerevisiae .", + "entities": [ + "Tcn1p", + "Crz1p" + ] + }, + { + "id": "3300", + "type": "gene", + "text": "We show here that the protein kinase MEKK1 can induce reporter gene expression from the atrial natriuretic factor ( ANF ) promoter , a genetic marker that is activated during in vivo hypertrophy .", + "entities": [ + "MEKK1", + "atrial natriuretic factor", + "ANF" + ] + }, + { + "id": "3301", + "type": "gene", + "text": "In order to determine which sequences in the GATA - 1 promoter are crucial for activation by the ME26 viral protein , we made deletions of the promoter , cloned them into a luciferase expression vector and tested their activity in mouse fibroblasts , which do not express GATA - 1 .", + "entities": [ + "GATA - 1 promoter", + "ME26 viral protein", + "luciferase", + "GATA - 1" + ] + }, + { + "id": "3302", + "type": "gene", + "text": "New - onset angina preceding acute myocardial infarction is associated with improved contractile recovery after thrombolysis .", + "entities": [] + }, + { + "id": "3303", + "type": "gene", + "text": "Kinetics of calcium metabolism .", + "entities": [] + }, + { + "id": "3304", + "type": "gene", + "text": "Wild - type protein bound azido - ATP well , but mutants with substitutions in the consensus amino acids were unable to bind azido - ATP .", + "entities": [] + }, + { + "id": "3305", + "type": "gene", + "text": "The Penn State Worry Questionnaire for Children ( PSWQ - C ) is a 14 - item self - report questionnaire that intends to measure the tendency of children to engage in excessive , generalized , and uncontrollable worry ( Chorpita et al . , Behav .", + "entities": [] + }, + { + "id": "3306", + "type": "gene", + "text": "Erythema exsudativum multiforme induced by granulocyte colony - stimulating factor in an allogeneic peripheral blood stem cell donor .", + "entities": [ + "granulocyte colony - stimulating factor" + ] + }, + { + "id": "3307", + "type": "gene", + "text": "Fatal apneusis was observed under following conditions : ( 1 ) Persistent apnea was produced after a single KA microinjection in one side of the VRG - Apa ( 5 animals ) .", + "entities": [] + }, + { + "id": "3308", + "type": "gene", + "text": "The FinO protein of IncF plasmids binds FinP antisense RNA and its target , traJ mRNA , and promotes duplex formation .", + "entities": [ + "FinO protein", + "FinP antisense RNA", + "traJ mRNA" + ] + }, + { + "id": "3309", + "type": "gene", + "text": "Responses to the Plowright Rinderpest vaccine by 43 calves and 70 adult cattle in Uganda in 1990 , through the production of IgG antibodies , were monitored for 4 weeks using the ELISA assay .", + "entities": [ + "IgG antibodies" + ] + }, + { + "id": "3310", + "type": "gene", + "text": "The nonconsensus TATA box in promoter B plays a more important role in promoter activity than the TATA box in promoter A .", + "entities": [] + }, + { + "id": "3311", + "type": "gene", + "text": "The coding region of 2385 nucleotides corresponds to a polypeptide chain of 795 amino acids , giving a molecular weight of 91 , 555 for the hsp108 protein .", + "entities": [ + "hsp108 protein" + ] + }, + { + "id": "3312", + "type": "gene", + "text": "This is particularly intriguing because SKUT - 1B - 20 cells lack the transcription factor Pit - 1 .", + "entities": [ + "Pit - 1" + ] + }, + { + "id": "3313", + "type": "gene", + "text": "For smaller vessels up to a diameter of 0 . 5 mm , treatments at 16 and 18 J / cm2 showed good results in 60 and 82 % respectively ; for vessels up to 1 mm in 27 and 33 % .", + "entities": [] + }, + { + "id": "3314", + "type": "gene", + "text": "These techniques have been used by many people for many years and no claim is being made for any innovation in this regard .", + "entities": [] + }, + { + "id": "3315", + "type": "gene", + "text": "Hospital hit for hiring AHERF physicians .", + "entities": [] + }, + { + "id": "3316", + "type": "gene", + "text": "However , only complete DnaJ can cooperate with DnaK and a third protein , GrpE , in refolding denatured firefly luciferase .", + "entities": [ + "complete DnaJ", + "DnaK", + "GrpE", + "denatured firefly luciferase" + ] + }, + { + "id": "3317", + "type": "gene", + "text": "The former procedure is economical but complicated , whereas the latter is simple and labour - saving , but a special ultrafiltration tube is required .", + "entities": [] + }, + { + "id": "3318", + "type": "gene", + "text": "There are many different proposals for the statistical analysis of data to determine early onset of action .", + "entities": [] + }, + { + "id": "3319", + "type": "gene", + "text": "Similarly , PCDFs / PCDDs ratio in ESP ash was lower than that in boiler ash .", + "entities": [] + }, + { + "id": "3320", + "type": "gene", + "text": "A genomic clone , pTt21 , containing DNA apparently transcribed specifically in Trypanosoma cruzi trypomastigotes , was obtained by differentially screening a genomic library with trypomastigote and epimastigote cDNA .", + "entities": [] + }, + { + "id": "3321", + "type": "gene", + "text": "The program has been written in a generic BASIC in order to make the procedure user - friendly .", + "entities": [] + }, + { + "id": "3322", + "type": "gene", + "text": "Abnormal intrapulmonary shunting ( IPS ) , which was proved in 4 cases by whole - body radionuclide scanning with 99mTc - MAA , is suggested as the major cause of cyanosis in liver cirrhosis .", + "entities": [] + }, + { + "id": "3323", + "type": "gene", + "text": "These results indicate that patients who undergo postoperative irradiation for low grade spinal astrocytomas and localized spinal ependymomas achieve excellent survival .", + "entities": [] + }, + { + "id": "3324", + "type": "gene", + "text": "Thus , two very different regulatory elements are used to mediate estrogen induction of related genes in chickens and amphibians .", + "entities": [] + }, + { + "id": "3325", + "type": "gene", + "text": "The solubility of all the mutated proteins was remarkably reduced .", + "entities": [] + }, + { + "id": "3326", + "type": "gene", + "text": "Together , these data support a model in which Tax anchors CBP to the HTLV - 1 promoter , with strong transcriptional activation resulting from the CBP - associated activities of nucleosome remodeling and recruitment of the general transcription machinery .", + "entities": [ + "Tax", + "CBP", + "HTLV - 1 promoter", + "CBP" + ] + }, + { + "id": "3327", + "type": "gene", + "text": "RPM / RGL3 resembled AF - 6 and Nore1 in interacting strongly with constitutively active M - Ras and p21 Ras .", + "entities": [ + "RPM", + "RGL3", + "AF - 6", + "Nore1", + "M - Ras", + "p21 Ras" + ] + }, + { + "id": "3328", + "type": "gene", + "text": "Changes in xanthine oxidase activity in patients with circulatory failure", + "entities": [ + "xanthine oxidase" + ] + }, + { + "id": "3329", + "type": "gene", + "text": "Drug effect , measured as postural sway , was also similar in the patients with cirrhosis and control subjects ; therefore the ratio of effect area under the curve to concentration area under the curve , a measure of sensitivity , did not differ significantly between the patients with cirrhosis and the control subjects .", + "entities": [] + }, + { + "id": "3330", + "type": "gene", + "text": "Forskolin treatment ( 10 microM ) of the transfected cells for 3 - - 6 h maximally induced luciferase threefold .", + "entities": [ + "luciferase" + ] + }, + { + "id": "3331", + "type": "gene", + "text": "The behavior of suf12 - null / SUF12 + heterozygotes indicates that suf12 is co - dominantly expressed and suggests that suf12 allele - specific suppression may result from functionally distinct mutant proteins rather than variation in residual wild - type SUF12 + activity .", + "entities": [ + "suf12 - null / SUF12 + heterozygotes", + "suf12", + "suf12", + "wild - type SUF12 +" + ] + }, + { + "id": "3332", + "type": "gene", + "text": "Mean ( + / - SE ) measurements of clearance ( 24 . 5 + / - 2 . 06 v 26 . 5 + / - 2 . 05 mL / min / m2 ) , half - life ( 5 . 7 + / - 0 . 5 v 6 . 4 + / - 0 . 5 hours ) , and volume of distribution ( 12 . 4 + / - 1 . 1 v 13 . 7 + / - 1 . 6 L / m2 ) were not significantly different in patients with jaundice when compared with controls .", + "entities": [] + }, + { + "id": "3333", + "type": "gene", + "text": "This points to a specific interference with HSV - induced DNA amplification .", + "entities": [] + }, + { + "id": "3334", + "type": "gene", + "text": "Oestrogen implant overdose .", + "entities": [] + }, + { + "id": "3335", + "type": "gene", + "text": "We show that stabilization of the hairpin reduced the amount of tRNA primer that is annealed to the PBS .", + "entities": [] + }, + { + "id": "3336", + "type": "gene", + "text": "We conclude that the SIMV is useful in weaning neonates from the ventilator .", + "entities": [] + }, + { + "id": "3337", + "type": "gene", + "text": "The costs were DM 11 , 562 for a PE , DM 12 , 477 for a VR and DM 7 , 532 for a MR .", + "entities": [] + }, + { + "id": "3338", + "type": "gene", + "text": "The localization of this proteoglycan locus in the human genome and the availability of new RFLPs provide the tools for future studies of human diseases where the HSPG2 proteoglycan gene is suspected to be involved .", + "entities": [ + "HSPG2 proteoglycan gene" + ] + }, + { + "id": "3339", + "type": "gene", + "text": "Analysis of liver biopsy specimens from patients with hepatitis showed a large variation in the mean iron content of the liver ferritin molecules .", + "entities": [ + "ferritin" + ] + }, + { + "id": "3340", + "type": "gene", + "text": "A third ORF , ORF5 , shows homology with gene agrB from Staphylococcus aureus , which is involved in the mechanism of regulation of the virulence phenotype in this species .", + "entities": [ + "gene agrB" + ] + }, + { + "id": "3341", + "type": "gene", + "text": "Other properties of Hg - and Cd - spores were similar to those of control spores .", + "entities": [] + }, + { + "id": "3342", + "type": "gene", + "text": "Oncogenic Raf - 1 activates p70 S6 kinase via a mitogen - activated protein kinase - independent pathway .", + "entities": [ + "Oncogenic Raf - 1", + "p70 S6 kinase", + "mitogen - activated protein kinase" + ] + }, + { + "id": "3343", + "type": "gene", + "text": "Characterization of the 5 ' - flanking region of the human multidrug resistance protein 2 ( MRP2 ) gene and its regulation in comparison withthe multidrug resistance protein 3 ( MRP3 ) gene .", + "entities": [ + "human multidrug resistance protein 2", + "MRP2", + "multidrug resistance protein 3", + "MRP3" + ] + }, + { + "id": "3344", + "type": "gene", + "text": "Mutation of TTF - 1 - binding sites ( TBE ) 1 , 3 , and 4 in combination markedly decreased transcriptional activity of SP - A promoter - chloramphenicol acetyltransferase constructs containing SP - A gene sequences from - 256 to + 45 .", + "entities": [ + "TTF - 1 - binding sites ( TBE ) 1 , 3 , and 4", + "SP - A", + "chloramphenicol acetyltransferase", + "SP - A gene" + ] + }, + { + "id": "3345", + "type": "gene", + "text": "Infants of this sample had monocular PL visual acuities similar to those established by McDonald et al . in a laboratory setting .", + "entities": [] + }, + { + "id": "3346", + "type": "gene", + "text": "A cDNA encoding the amino - terminal 17 % of apoB ( apoB17 ) was fused to a cDNA coding for the last 37 amino acids of decay - accelerating factor ( DAF ) , which contains the signal for glycosylphosphatidylinositol anchor attachment .", + "entities": [ + "apoB", + "apoB17", + "decay - accelerating factor", + "DAF" + ] + }, + { + "id": "3347", + "type": "gene", + "text": "Two distinct Salmonella fimbrins , AgfA and SefA , comprising thin aggregative fimbriae SEF17 and SEF14 , respectively , were each genetically engineered to carry PT3 , an alpha - helical 16 - amino acid Leishmania T - cell epitope derived from the metalloprotease gp63 .", + "entities": [ + "Salmonella fimbrins", + "AgfA", + "SefA", + "SEF17", + "SEF14", + "PT3", + "gp63" + ] + }, + { + "id": "3348", + "type": "gene", + "text": "Hypercalcemia associated with elevated serum PTH concentration indicating primary hyperparathyroidism was found in 7 BC patients ( 7 % ) and in none of healthy women or patients with thyroid cancer .", + "entities": [ + "serum PTH" + ] + }, + { + "id": "3349", + "type": "gene", + "text": "The workup included skin tests ( up to 1 microgram / ml , Pharmacia ) , measurement of specific serum IgE with RAST - CAP ( Pharmacia ) , and CAST with three concentrations of bee ( Apis mellifera ) and wasp ( Vespula spec . ) venom ( Aquagen ALK ) .", + "entities": [ + "IgE" + ] + }, + { + "id": "3350", + "type": "gene", + "text": "Our data showed that activation of the raf - ERK pathway led to activation of TF expression in breast carcinoma cells and suggested that constitutive activation of this pathway leads to high TF expression in MDA - MB - 231 cells .", + "entities": [ + "raf", + "ERK", + "TF", + "TF" + ] + }, + { + "id": "3351", + "type": "gene", + "text": "Recombinant I - kappa B alpha inhibited kappa B motif binding by nuclear factor - kappa B1 , RelA , and c - Rel as indicated by studies using UV radiation - induced covalent cross - linking to a bromodeoxyuridine - substituted kappa B oligonucleotide .", + "entities": [ + "Recombinant I - kappa B alpha", + "kappa B motif", + "nuclear factor - kappa B1", + "RelA", + "c - Rel", + "kappa B oligonucleotide" + ] + }, + { + "id": "3352", + "type": "gene", + "text": "SUMMARY OF REVIEW : We discuss the criteria that make such studies comparable , drawing on the experiences of recent studies performed around the world .", + "entities": [] + }, + { + "id": "3353", + "type": "gene", + "text": "When transfected into Drosophila SL - 2 cells , pCAT plasmid containing 2 , 090 bp of 5 ' - flanking region shows a 3 . 0 - to 3 . 5 - fold increase in chloramphenicol acetyltransferase activity after induction with retinoic acid and / or 8 - bromo - cAMP .", + "entities": [ + "chloramphenicol acetyltransferase" + ] + }, + { + "id": "3354", + "type": "gene", + "text": "We analysed two regions involved in preS2 / S gene transcription of the HBV adw subtype : the diverged TATA box and a putative initiator element .", + "entities": [ + "preS2", + "S gene" + ] + }, + { + "id": "3355", + "type": "gene", + "text": "BACKGROUND : Chemicals vary considerably in their intrinsic ability to cause allergic contact dermatitis .", + "entities": [] + }, + { + "id": "3356", + "type": "gene", + "text": "Results have surprisingly revealed the presence of three U14 snRNA - homologous regions positioned within introns 5 , 6 , and 8 of the mouse cognate hsc70 heat shock gene .", + "entities": [ + "U14 snRNA - homologous regions", + "hsc70" + ] + }, + { + "id": "3357", + "type": "gene", + "text": "Change in the makeup of the blood following a short - term local action of a permanent magnetic field on the human body", + "entities": [] + }, + { + "id": "3358", + "type": "gene", + "text": "The 12 , 000 MW ( 12K ) IE polypeptide encoded by IEmRNA - 5 is translated from an 88 codon open reading frame , leaving a 1200 base 3 ' non - translated region .", + "entities": [ + "12 , 000 MW ( 12K ) IE polypeptide", + "IEmRNA - 5" + ] + }, + { + "id": "3359", + "type": "gene", + "text": "BACKGROUND : Defensins , also known as human neutrophil peptides , are antimicrobial peptides present in the azurophil granules of neutrophils .", + "entities": [ + "Defensins", + "human neutrophil peptides" + ] + }, + { + "id": "3360", + "type": "gene", + "text": "Isolation and characterization of SRF accessory proteins .", + "entities": [ + "SRF accessory proteins" + ] + }, + { + "id": "3361", + "type": "gene", + "text": "The authors evaluate the clinical efficacy of EMB AZS in recurrent ulcer after operation on the stomach caused by a high level of acid production and ulcerative gastroduodenal bleeding .", + "entities": [] + }, + { + "id": "3362", + "type": "gene", + "text": "Our findings support the view of a multifactorial genesis of the cardiac involvement in uremic patients .", + "entities": [] + }, + { + "id": "3363", + "type": "gene", + "text": "Osmotic shock stimulates GLUT4 translocation in 3T3L1 adipocytes by a novel tyrosine kinase pathway .", + "entities": [ + "GLUT4", + "tyrosine kinase" + ] + }, + { + "id": "3364", + "type": "gene", + "text": "The percentages of formed cysts and growth rates were monthly estimated and analyzed rhythmometrically by cosinor for 5 clonal cultures of Scripsiella trochoidea Stein grown for 2 years under laboratory conditions , rended as constant as possible from the view point of environmental temperature ( 24 + / - 1 degree C ) , lighting ( 25 microEin m - 2 s - 1 ) , and artificial seawater .", + "entities": [] + }, + { + "id": "3365", + "type": "gene", + "text": "Inspection of enhancer mutants suggests that trans - activation by hLEF / GAL4 is especially dependent on TCF - 2 , a distinct T - cell - enriched protein that binds to sequences flanking the hLEF - binding site in the enhancer .", + "entities": [ + "hLEF", + "GAL4", + "TCF - 2", + "hLEF - binding site" + ] + }, + { + "id": "3366", + "type": "gene", + "text": "In mammals , the Rb protein interacts specifically with D - type cyclins and regulates cell proliferation by binding and inhibiting E2F transcription factors .", + "entities": [ + "Rb protein", + "D - type cyclins", + "E2F transcription factors" + ] + }, + { + "id": "3367", + "type": "gene", + "text": "Here we show that calpeptin inhibits tyrosine phosphatases , enhancing tyrosine phosphorylation particularly of paxillin .", + "entities": [ + "calpeptin", + "tyrosine phosphatases", + "paxillin" + ] + }, + { + "id": "3368", + "type": "gene", + "text": "However , mutations in the HNF - 4 binding site on element CIIB and inhibition of HNF - 4 synthesis in HepG2 cells by antisense HNF - 4 constructs decreased the apoCII promoter activity to 25 - 40 % of the control , indicating that HNF - 4 is a positive regulator of the apoCII gene .", + "entities": [ + "HNF - 4 binding site", + "element CIIB", + "HNF - 4", + "HNF - 4 constructs", + "apoCII promoter", + "HNF - 4", + "apoCII gene" + ] + }, + { + "id": "3369", + "type": "gene", + "text": "Outflow obstruction of pancreatic juice , i . e . , \" relative stenosis of the minor papilla , \" was considered to be present in the patients with type II papilla , and , therefore , the patients with type II papilla might suffer from acute pancreatitis resulting from poor drainage of pancreatic juice and excessive pressure in the dorsal duct .", + "entities": [] + }, + { + "id": "3370", + "type": "gene", + "text": "The in vitro antibacterial potency is greatest when the 1 - substituent is 2 , 4 - difluorophenyl and the 7 - substituent is a 3 - amino - 1 - pyrrolidinyl group .", + "entities": [] + }, + { + "id": "3371", + "type": "gene", + "text": "METHODS : Sixteen pigs were assigned randomly to control and shock groups .", + "entities": [] + }, + { + "id": "3372", + "type": "gene", + "text": "Since myoglobin is co - extracted with the hemoglobin , the 2 heme pigments are separated in one portion of the extract by precipitating the hemoglobin in an 85 % ( NH4 ) 2SO4 solution .", + "entities": [ + "myoglobin", + "hemoglobin", + "hemoglobin" + ] + }, + { + "id": "3373", + "type": "gene", + "text": "The role of intraoperative echocardiography in surgery of the heart and large vessels", + "entities": [] + }, + { + "id": "3374", + "type": "gene", + "text": "PMEK1 displays 96 and 80 % identity respectively with the tobacco NTF3 and Arabidopsis ATMPK1 kinases , and only 50 % to the more distantly related plant MAP kinase MsERK1 from alfalfa .", + "entities": [ + "PMEK1", + "tobacco NTF3", + "Arabidopsis ATMPK1 kinases", + "MsERK1" + ] + }, + { + "id": "3375", + "type": "gene", + "text": "These regions contain inverted E - box palindromic or direct repeat motifs and bind SREBP - 1 with different affinities .", + "entities": [ + "SREBP - 1" + ] + }, + { + "id": "3376", + "type": "gene", + "text": "After i . v .", + "entities": [] + }, + { + "id": "3377", + "type": "gene", + "text": "Cardiac myosin - binding protein C ( MyBP - C ) : identification of protein kinase A and protein kinase C phosphorylation sites .", + "entities": [ + "Cardiac myosin - binding protein C", + "MyBP - C", + "protein kinase A", + "protein kinase C" + ] + }, + { + "id": "3378", + "type": "gene", + "text": "The most common grade 3 toxicity was neutropenia , thrombocytopenia , and parasthesias ( observed in < 10 % of cycles ) .", + "entities": [] + }, + { + "id": "3379", + "type": "gene", + "text": "We have therefore studied the molecular mechanisms of TGF - beta1 action on thyroglobulin ( TG ) gene expression by focusing our attention on TGF - beta1 regulation of thyroid - specific transcription factors .", + "entities": [ + "TGF - beta1", + "thyroglobulin", + "TG", + "TGF - beta1" + ] + }, + { + "id": "3380", + "type": "gene", + "text": "Approximately 50 % of the ribosomal DNA ( rDNA ) units of Drosophila melanogaster are inactivated by two different 28 S RNA ribosomal gene insertions ( type I and type II ) .", + "entities": [ + "28 S RNA ribosomal gene" + ] + }, + { + "id": "3381", + "type": "gene", + "text": "Receptors for interleukin ( IL ) - 10 and IL - 6 - type cytokines use similar signaling mechanisms for inducing transcription through IL - 6 response elements .", + "entities": [ + "interleukin ( IL ) - 10", + "IL - 6 - type cytokines", + "IL - 6" + ] + }, + { + "id": "3382", + "type": "gene", + "text": "Expression of thymidine kinase gene in normal human diploid cells is both cell cycle - and age - dependent and appears to be transcriptionally regulated .", + "entities": [ + "thymidine kinase gene" + ] + }, + { + "id": "3383", + "type": "gene", + "text": "It was found that intrathecal administration ( i . t . ) of D2 receptor agonist LY171555 or D1 / D2 receptor agonist apomorphine increased pain threshold and had a potentiating effect on AA .", + "entities": [ + "D2 receptor", + "D1 / D2 receptor" + ] + }, + { + "id": "3384", + "type": "gene", + "text": "This region binds two ubiquitous nuclear factors , USF / MLTF and the CAAT - binding transcription factor / nuclear factor 1 ( CTF / NF1 ) .", + "entities": [ + "USF", + "MLTF", + "CAAT - binding transcription factor", + "nuclear factor 1", + "CTF", + "NF1" + ] + }, + { + "id": "3385", + "type": "gene", + "text": "In 15 ventilator - dependent , SB , and actively expiring patients , we found that the difference PEEP ( i ) , dyn - Pga , total decay ( mean + / - SD , 5 . 7 + / - 1 . 9 cm H ( 2 ) O ) was quite similar to PEEP ( i ) , dyn ref ( 5 . 3 + / - 1 . 9 cm H ( 2 ) O ) .", + "entities": [] + }, + { + "id": "3386", + "type": "gene", + "text": "Naloxone ( 2 mg / kg bolus + 2 mg X kg - 1 X h - 1 ) was given with one of the two doses of the lipopolysaccharide .", + "entities": [] + }, + { + "id": "3387", + "type": "gene", + "text": "Finally , we show that complexes similar to the C25 , C30 and C35 complexes are formed by rat cortex nuclear extracts and the SAA element in EMSA experiments , suggesting the relevance of our in vitro observations to the in vivo functioning of the rat APP promoter .", + "entities": [ + "C25", + "C30", + "C35 complexes", + "rat APP promoter" + ] + }, + { + "id": "3388", + "type": "gene", + "text": "Nucleoprotein ( N ) expressed by both recombinant vaccinia virus and TGEV had a relative molecular mass ( Mr ) of 47 , 000 and was susceptible to degradation at the C - terminus yielding discrete breakdown products .", + "entities": [] + }, + { + "id": "3389", + "type": "gene", + "text": "PURPOSE : To evaluate the disease - free survival ( DFS ) and overall survival ( OS ) , prognostic factors , and treatment - related mortality of women with stage IIIB inflammatory breast cancer ( IBC ) treated with combined modality therapy ( CMT ) and high - dose chemotherapy ( HDCT ) with autologous stem - cell transplantation .", + "entities": [] + }, + { + "id": "3390", + "type": "gene", + "text": "Our findings further our understanding of how ZBP - 89 modulates cell proliferation and reveals a novel mechanism by which the p53 protein is stabilized .", + "entities": [ + "ZBP - 89", + "p53 protein" + ] + }, + { + "id": "3391", + "type": "gene", + "text": "Nuclear beta II PKC , like p34cdc2 kinase , may function to regulate nuclear lamina structural stability during cell cycle .", + "entities": [ + "Nuclear beta II PKC", + "p34cdc2 kinase" + ] + }, + { + "id": "3392", + "type": "gene", + "text": "The latter domain appears to be involved in targeting Num1p to the mother cell cortex .", + "entities": [ + "Num1p" + ] + }, + { + "id": "3393", + "type": "gene", + "text": "Managing vertigo and vertigo syndromes in the elderly", + "entities": [] + }, + { + "id": "3394", + "type": "gene", + "text": "Moreover , in one patient with a sarcoma who underwent a leg - sparing procedure , no sciatic nerve enlargement was seen postoperatively .", + "entities": [] + }, + { + "id": "3395", + "type": "gene", + "text": "Dermoid cyst in a free skin flap as the complication after treatment of recurring hernia", + "entities": [] + }, + { + "id": "3396", + "type": "gene", + "text": "The performance of three commonly used chemical cartridge respirators for SO2 was measured under working conditions in a copper smelter .", + "entities": [] + }, + { + "id": "3397", + "type": "gene", + "text": "The identity between hnRNPs H and H ' is 96 % , between H and F 78 % , and between H ' and F 75 % , respectively .", + "entities": [ + "hnRNPs H", + "H '", + "H", + "F", + "H '", + "F" + ] + }, + { + "id": "3398", + "type": "gene", + "text": "TCR alpha and beta gene expression may be regulated by a common set of T - cell nuclear proteins in that the T beta 2 element binding a set of cyclic AMP response element - binding proteins that are also bound by the T alpha 1 element of the human TCR alpha enhancer and the decamer element present in a large number of human and murine TCR beta promoters .", + "entities": [ + "TCR alpha and beta gene", + "T - cell nuclear proteins", + "T beta 2 element", + "cyclic AMP response element - binding proteins", + "T alpha 1 element", + "TCR alpha", + "TCR beta" + ] + }, + { + "id": "3399", + "type": "gene", + "text": "However , in TF - 1 cells grown on GM - CSF before starvation , CREB phosphorylation was observed 10 minutes after PIXY321 stimulation .", + "entities": [ + "GM - CSF", + "CREB", + "PIXY321" + ] + }, + { + "id": "3400", + "type": "gene", + "text": "When combined with serum ferritin and hemoglobin determinations , the serum transferrin receptor assay is a valuable addition in epidemiologic surveys because it provides a quantitative measure of functional iron deficiency and it distinguishes true IDA from the anemia of chronic disease .", + "entities": [ + "ferritin", + "hemoglobin", + "transferrin receptor" + ] + }, + { + "id": "3401", + "type": "gene", + "text": "The absence of H4PteGlun bound to the T protein in our experimental conditions demonstrates that H4PteGlun is not covalently linked to the T protein .", + "entities": [ + "T protein", + "T protein" + ] + }, + { + "id": "3402", + "type": "gene", + "text": "A case of a dense epidermoid cyst of the suprasellar cistern is presented .", + "entities": [] + }, + { + "id": "3403", + "type": "gene", + "text": "Resultant activation of c - Jun N - terminal kinase / stress - activated protein kinase ( JNK / SAPK ) .", + "entities": [ + "c - Jun N - terminal kinase", + "stress - activated protein kinase", + "JNK", + "SAPK" + ] + }, + { + "id": "3404", + "type": "gene", + "text": "For colostral milk there was a significant correlation of vitamin K1 to cholesterol ( r = 0 . 62 ) but not to total lipid or phospholipid suggesting a role for cholesterol in the secretion of vitamin K1 into colostral milk .", + "entities": [] + }, + { + "id": "3405", + "type": "gene", + "text": "Members of the MAPK family include the extracellular response kinases ( ERKs or p42 / 44 ( MAPK ) ) , the c - Jun amino - terminal kinases ( JNKs ) , and the p38 / Hog 1 protein kinases .", + "entities": [ + "MAPK family", + "extracellular response kinases", + "ERKs", + "p42 / 44", + "MAPK", + "c - Jun amino - terminal kinases", + "JNKs", + "p38", + "Hog 1" + ] + }, + { + "id": "3406", + "type": "gene", + "text": "Two additional cis - acting sequences , conserved in both the region 1 and 3 promoters , were identified , suggesting a role for these sequences in the coordinate regulation of transcription from these promoters .", + "entities": [] + }, + { + "id": "3407", + "type": "gene", + "text": "Diagnosis of primary sclerosing cholangitis in a blood donor with elevated serum alanine aminotransferase .", + "entities": [ + "serum alanine aminotransferase" + ] + }, + { + "id": "3408", + "type": "gene", + "text": "Mutational analysis shows that both an AP - 1 like sequence ( - 294 / - 285 , TGAATCATCA ) and an A / T - rich myocyte enhancer factor ( MEF ) - 2 like sequence ( - 310 / - 298 , TTAAAAATAAAAA ) in the 33 - bp region are necessary for the OP - 1 effect .", + "entities": [ + "AP - 1 like sequence", + "myocyte enhancer factor ( MEF ) - 2 like sequence", + "OP - 1" + ] + }, + { + "id": "3409", + "type": "gene", + "text": "The partial sequence of the 62 - kDa nuclear pore glycoprotein shows little similarity to other characterized proteins and elucidates structural features of a member of the family of nuclear pore glycoproteins .", + "entities": [ + "62 - kDa nuclear pore glycoprotein", + "nuclear pore glycoproteins" + ] + }, + { + "id": "3410", + "type": "gene", + "text": "Based on sequence homology , the genes were identified as TEF , encoding translation elongation factor - 1 alpha and RPS7 , encoding ribosomal protein S7 .", + "entities": [ + "TEF", + "translation elongation factor - 1 alpha", + "RPS7", + "S7" + ] + }, + { + "id": "3411", + "type": "gene", + "text": "In 18 % lymphography was clearly positive and CT negative .", + "entities": [] + }, + { + "id": "3412", + "type": "gene", + "text": "The results indicated that two genes ( citA and citB ) have separate promoters , and the location of the promoter for the citB gene in the Tn3411 nucleotide sequence was different from that in pMS185 .", + "entities": [ + "citA", + "citB", + "citB gene", + "Tn3411" + ] + }, + { + "id": "3413", + "type": "gene", + "text": "The oral temperature rose and the serum creatine kinase levels fell only in those patients who were actively warmed .", + "entities": [ + "serum creatine kinase" + ] + }, + { + "id": "3414", + "type": "gene", + "text": "The mechanism of peroxisome proliferation is poorly understood .", + "entities": [] + }, + { + "id": "3415", + "type": "gene", + "text": "In fact , families of polypeptides were produced by initiation of translation at AUG codons within sequences coding for VP1 and T , presumably as a result of transcription initiation events that generated 5 ' ends immediately upstream from these AUGs .", + "entities": [ + "VP1", + "T" + ] + }, + { + "id": "3416", + "type": "gene", + "text": "Comparison of sequences from - 215 to + 1 bp identified consensus binding sites for the homeodomain transcription factor thyroid transcription factor - 1 ( TTF - 1 ) .", + "entities": [ + "thyroid transcription factor - 1", + "TTF - 1" + ] + }, + { + "id": "3417", + "type": "gene", + "text": "Lac operators were introduced into several positions within the CAB promoter and operator - free plasmid was used as control .", + "entities": [ + "Lac", + "CAB promoter" + ] + }, + { + "id": "3418", + "type": "gene", + "text": "Our results indicate that Gab1 is involved in the control of egr - 1 expression regulated by insulin .", + "entities": [ + "Gab1", + "egr - 1", + "insulin" + ] + }, + { + "id": "3419", + "type": "gene", + "text": "These data demonstrate that paxillin localizes to focal adhesions independent of interactions with vinculin and / or FAK , and represents the first definitive demonstration of LIM domains functioning as a primary determinant of protein subcellular localization to focal adhesions .", + "entities": [ + "paxillin", + "vinculin", + "FAK", + "LIM domains" + ] + }, + { + "id": "3420", + "type": "gene", + "text": "It has been proposed that insulin resistance ( IR ) underlies a cluster of cardiovascular disease ( CVD ) risk factors constituting a \" metabolic syndrome . \" CVD is a leading cause of premature mortality among indigenous Australians .", + "entities": [ + "insulin" + ] + }, + { + "id": "3421", + "type": "gene", + "text": "Comparison to other coxI genes revealed a 966 - bp group I intron , which , based on homology with the related yeast coxI intron aI4 , potentially encodes a 279 - amino - acid site - specific DNA endonuclease .", + "entities": [ + "coxI genes", + "yeast coxI intron aI4", + "DNA endonuclease" + ] + }, + { + "id": "3422", + "type": "gene", + "text": "The electromyographically recorded responses consisted of an early R1 response in the orbicularis oculi muscle ipsilateral to the side of stimulation , a bilateral late response ( ipsilateral R2 and contralateral Rc ) and a third , R3 response , in the ipsilateral orbicularis oculi muscle .", + "entities": [] + }, + { + "id": "3423", + "type": "gene", + "text": "The Abbreviated Injury Scale ( AIS ) , Injury Severity Scale and TRISS methodology comprise a mathematically sound system for the analysis of injuries and injured patients .", + "entities": [] + }, + { + "id": "3424", + "type": "gene", + "text": "Platelet aggregation in response to 10 micrograms collagen / ml was decreased in parallel after treatment with ASA .", + "entities": [ + "collagen" + ] + }, + { + "id": "3425", + "type": "gene", + "text": "Cervicovaginal foetal fibronectin in the prediction of preterm labour in a low - risk population .", + "entities": [ + "foetal fibronectin" + ] + }, + { + "id": "3426", + "type": "gene", + "text": "The systolic pressure gradient ( SPG ) between the left ventricle ( LV ) and left atrium ( LA ) was obtained from high - fidelity pressure transducers .", + "entities": [] + }, + { + "id": "3427", + "type": "gene", + "text": "The main aim of the contribution , which opens an arena for discussion on the Rivista dell ' Infermiere is to critically appraise published research works focusing both on strengths and novelty and weaknesses in the hypothesis formulation , methods and instruments used , discussion of results .", + "entities": [] + }, + { + "id": "3428", + "type": "gene", + "text": "This site acts as a negative element when transferred to the thymidine kinase promoter , but does not confer inducibility .", + "entities": [ + "thymidine kinase promoter" + ] + }, + { + "id": "3429", + "type": "gene", + "text": "In conclusion , obesity , alcohol intake , and multimetabolic disorders were determined to be independent predictors for the development of hyperuricemia .", + "entities": [] + }, + { + "id": "3430", + "type": "gene", + "text": "When the 73 - bp fragment was fused to an alpha1 - globin promoter - CAT construct and cotransfected with CCAAT transcription factor 1 ( CTF1 ) / NF1 into Drosophila Schneider SL2 insect cells ( which lack NF1 - like proteins ) trans - activation of CAT activity was observed .", + "entities": [ + "alpha1 - globin", + "CAT", + "CCAAT transcription factor 1", + "CTF1", + "NF1", + "NF1 - like proteins", + "CAT" + ] + }, + { + "id": "3431", + "type": "gene", + "text": "We conclude that pancreatic polypeptide and motilin responses to a meal are different in encopretic children than in children in the control group .", + "entities": [ + "motilin" + ] + }, + { + "id": "3432", + "type": "gene", + "text": "An integrated RTC algorithm for the urban wastewater system is formulated , the parameters of which are optimized using various global optimization routines .", + "entities": [] + }, + { + "id": "3433", + "type": "gene", + "text": "Attitudes were found to be multidimensional , with similar dimensions being identified in both samples .", + "entities": [] + }, + { + "id": "3434", + "type": "gene", + "text": "Our results show that the ORF of hAMPK encodes 552 amino acids ( aa ) ( 62 . 250 kDa ) and is highly conserved with rAMPK with identities of 97 . 3 and 90 % at the aa and nt levels , respectively .", + "entities": [ + "hAMPK", + "rAMPK" + ] + }, + { + "id": "3435", + "type": "gene", + "text": "Moreover , we found that cyclin E , in contrast to cyclin D1 , was required for the G1 / S transition even in cells lacking retinoblastoma protein function .", + "entities": [ + "cyclin E", + "cyclin D1", + "retinoblastoma protein" + ] + }, + { + "id": "3436", + "type": "gene", + "text": "PaO2 threshold was determined through an indwelling O2 sensor catheter .", + "entities": [] + }, + { + "id": "3437", + "type": "gene", + "text": "The active site includes the acidic triad Asp53 ( the site of phosphorylation ) , Asp10 and Glu9 .", + "entities": [] + }, + { + "id": "3438", + "type": "gene", + "text": "Physiology and Physiopathology", + "entities": [] + }, + { + "id": "3439", + "type": "gene", + "text": "The examination must include T1 and T2 sequences and scans in three planes .", + "entities": [] + }, + { + "id": "3440", + "type": "gene", + "text": "Effects of temperature and moulting cycle on melanin synthesis in the newt , Triturus cristatus .", + "entities": [] + }, + { + "id": "3441", + "type": "gene", + "text": "To begin to examine the mechanism controlling expression of this gene during the cell - cycle , a mouse B - myb 5 ' flanking sequence was isolated from a cosmid library and shown to promote efficiently the transcription of a luciferase reporter gene when transfected into NIH3T3 fibroblasts .", + "entities": [ + "mouse B - myb 5 ' flanking sequence", + "luciferase reporter gene" + ] + }, + { + "id": "3442", + "type": "gene", + "text": "A clinically useful diagnostic method has been developed for detecting and quantitating periods of apnea in pediatric patients .", + "entities": [] + }, + { + "id": "3443", + "type": "gene", + "text": "Simultaneous determination of theophylline and its metabolites by HPLC ] A high performance liquid chromatography ( HPLC ) method has been developed for the simultaneous determination of theophylline and its metabolites , with caffeine and its metabolites .", + "entities": [] + }, + { + "id": "3444", + "type": "gene", + "text": "Greater attenuation of the N1 - P2 and baseline - P2 amplitude of the probe EPs was observed when the probe stimulus was presented to the right ear and the verbal material presented to the left ear than when the opposite stimulation arrangement was used .", + "entities": [] + }, + { + "id": "3445", + "type": "gene", + "text": "This effect and the fact that all three doses were toxic to the dams dictated that a second experiment be carried out at lower doses .", + "entities": [] + }, + { + "id": "3446", + "type": "gene", + "text": "Histological slides of one biopsy of each patient ( formalin - fixed and paraffin - embedded ) were stained with a Modified Giemsa ( MG ) , the Warthin - Starry ( WS ) , and an immunohistochemical method ( IMM ) using purified polyclonal H . pylori antiserum ( DAKO B471 ) .", + "entities": [] + }, + { + "id": "3447", + "type": "gene", + "text": "An examination was performed in 15 patients who had developed pronounced osteomalacia following gastric resection .", + "entities": [] + }, + { + "id": "3448", + "type": "gene", + "text": "Intravenous gamma globulins", + "entities": [] + }, + { + "id": "3449", + "type": "gene", + "text": "Year one of the first general practitioner medical unit in the greater Glasgow area .", + "entities": [] + }, + { + "id": "3450", + "type": "gene", + "text": "The sequenced genomic region thus accounts for essentially all of the longest known transcript ( 4 . 5 kb ) , although the precise ends of this transcript have not been defined .", + "entities": [] + }, + { + "id": "3451", + "type": "gene", + "text": "This conclusion was confirmed by Northern blotting analysis of the 5 ' - flanking region of CAD gene .", + "entities": [ + "CAD gene" + ] + }, + { + "id": "3452", + "type": "gene", + "text": "OBJECTIVES : To assess the ability of pretreatment and post - treatment prostate - specific antigen ( PSA ) measurements , clinical tumor stage , tumor grade , Gleason sum , race , age , and radiation dose to predict the recurrence of prostate cancer following external beam radiation therapy ( XRT ) since the introduction of PSA as a tumor marker at one tertiary care center .", + "entities": [ + "prostate - specific antigen", + "PSA", + "PSA" + ] + }, + { + "id": "3453", + "type": "gene", + "text": "The acfD gene encompasses 254 nt that are predicted to encode an 88 - amino - acid ( aa ) protein .", + "entities": [ + "acfD gene" + ] + }, + { + "id": "3454", + "type": "gene", + "text": "The effect of emotional - painful stress ( EPS ) on myocardial extensibility and contractility was studied on an isolated rat atrium .", + "entities": [] + }, + { + "id": "3455", + "type": "gene", + "text": "Previous experience and contextual cues are essential elements in the generation of a subjective prediction .", + "entities": [] + }, + { + "id": "3456", + "type": "gene", + "text": "Since August 1994 , the ENRP has retained 70 . 3 metric tons of TP that otherwise would have entered the Everglades .", + "entities": [] + }, + { + "id": "3457", + "type": "gene", + "text": "Molecular characterization of a large Borrelia burgdorferi motility operon which is initiated by a consensus sigma70 promoter .", + "entities": [ + "sigma70 promoter" + ] + }, + { + "id": "3458", + "type": "gene", + "text": "Interestingly , in the adult , transgene expression patterns within the cerebellum in two lines appeared to mark distinct anterior - posterior compartments .", + "entities": [] + }, + { + "id": "3459", + "type": "gene", + "text": "Furthermore , this element confers p53 induction to the otherwise nonresponsive adenovirus major late promoter .", + "entities": [ + "p53" + ] + }, + { + "id": "3460", + "type": "gene", + "text": "The elm1 kinase functions in a mitotic signaling network in budding yeast .", + "entities": [ + "elm1 kinase" + ] + }, + { + "id": "3461", + "type": "gene", + "text": "A further mechanism increasing specific activation was cooperation of receptors at multiple and weak HREs , which was accentuated in the presence of both the AR N terminus and ligand binding domain .", + "entities": [ + "AR" + ] + }, + { + "id": "3462", + "type": "gene", + "text": "3600 - fold to apparent homogeneity with a 41 % yield by affinity chromatography utilizing DNA - cellulose ; the purity of the final preparation was assessed by SDS / PAGE , lack of contamination by other nucleases and production of a monospecific antibody against the enzyme .", + "entities": [] + }, + { + "id": "3463", + "type": "gene", + "text": "Some strains of A . parasiticus produced all four aflatoxins B1 B2 G1 G2 , while the other ones produced AF B1 + G1 only , with concentrations of aflatoxins from 0 . 1 to 450 mg / kg .", + "entities": [] + }, + { + "id": "3464", + "type": "gene", + "text": "Possible roles of RAD5 putative ATPase / DNA helicase activity in DNA repair and in the maintenance of wild - type rates of instability of simple repetitive sequences are discussed .", + "entities": [ + "RAD5", + "ATPase", + "DNA helicase" + ] + }, + { + "id": "3465", + "type": "gene", + "text": "Interaction was apparently determined by the N - terminal splice region of RPDE - 6 , as the PDE4A splice variant RPDE - 39 , which differs from RPDE - 6 at the extreme N - terminus , failed to associate with v - Src - SH3 ; met26RD1 ( where RD1 is rat ' dunc - like ' PDE ) , which has the N - terminal splice region deleted , failed to associate with v - Src - SH3 , and the association of RPDE - 6 and v - Src - SH3 was blocked by a fusion protein formed from the N - terminal splice region .", + "entities": [ + "RPDE - 6", + "PDE4A", + "RPDE - 39", + "RPDE - 6", + "v - Src", + "SH3", + "met26RD1", + "RD1", + "rat ' dunc - like ' PDE", + "v - Src", + "SH3", + "RPDE - 6", + "v - Src", + "SH3" + ] + }, + { + "id": "3466", + "type": "gene", + "text": "All these processes were fully developed during the last month of pregnancy , offering the same picture as the controls .", + "entities": [] + }, + { + "id": "3467", + "type": "gene", + "text": "Vitrectomy with an alternative instrument system .", + "entities": [] + }, + { + "id": "3468", + "type": "gene", + "text": "FZD4 is homologous to FZD9 and FZD10 , and overall amino acid identity is as follows : FZD4 vs FZD9 , 51 . 6 % ; FZD4 vs FZD10 , 51 . 2 % ; FZD9 vs FZD10 , 65 . 7 % .", + "entities": [ + "FZD4", + "FZD9", + "FZD10", + "FZD4", + "FZD9", + "FZD4", + "FZD10", + "FZD9", + "FZD10" + ] + }, + { + "id": "3469", + "type": "gene", + "text": "Intracranial arachnoid cyst of the middle fossa demonstrated by positive 99mTc brainscintigraphy .", + "entities": [] + }, + { + "id": "3470", + "type": "gene", + "text": "The mean change in HbA1 , adjusted for the initial value , was - 0 . 4 % in the experimental and + 0 . 5 % in the control group ( p less than 0 . 05 ) .", + "entities": [ + "HbA1" + ] + }, + { + "id": "3471", + "type": "gene", + "text": "SECONDARY OUTCOME MEASURE - - Double - blind caffeine - withdrawal evaluation .", + "entities": [] + }, + { + "id": "3472", + "type": "gene", + "text": "Patch test results obtained with corticosteroid allergic patients tested with a large corticosteroid series validated the earlier classification of corticosteroid molecules in four groups of cross - reacting molecules : i . e . , group A ( hydrocortisone type ) , group B ( acetonides ) , group C ( betamethasone type - non esterified ) and group D ( esters ) .", + "entities": [] + }, + { + "id": "3473", + "type": "gene", + "text": "In the absence of other stabilizers , increased sucrose can provide increased thermoresistance to the virus in 2 . 5 % albumin .", + "entities": [ + "albumin" + ] + }, + { + "id": "3474", + "type": "gene", + "text": "The underlying cirrhosis was alcoholic in 11 ( 53 . 3 % ) , cryptogenic in 5 ( 23 . 8 % ) , and hepatitis B chronic infection related in 5 ( 23 . 8 % ) .", + "entities": [] + }, + { + "id": "3475", + "type": "gene", + "text": "Partial correction of anemia with recombinant human erythropoietin likely reduces left ventricular mass and volume .", + "entities": [ + "recombinant human erythropoietin" + ] + }, + { + "id": "3476", + "type": "gene", + "text": "Some of the peptide : MBP fusions were also analyzed using surface plasmon resonance .", + "entities": [ + "peptide : MBP fusions" + ] + }, + { + "id": "3477", + "type": "gene", + "text": "To discern whether these disorders of GnRH deficiency are associated with altered melatonin secretion profiles , we compared untreated young males IGD ( n = 7 ) and DP ( n = 7 ) to normal pubertal male controls ( n = 6 ) .", + "entities": [ + "GnRH" + ] + }, + { + "id": "3478", + "type": "gene", + "text": "The manifestations often include a moderate thrombocytopenia and , less commonly , hemolysis .", + "entities": [] + }, + { + "id": "3479", + "type": "gene", + "text": "Epidermal growth factor receptor transcriptionally up - regulates vascular endothelial growth factor expression in human glioblastoma cells via a pathway involving phosphatidylinositol 3 ' - kinase and distinct from that induced by hypoxia .", + "entities": [ + "Epidermal growth factor receptor", + "vascular endothelial growth factor", + "phosphatidylinositol 3 ' - kinase" + ] + }, + { + "id": "3480", + "type": "gene", + "text": "Animal experimental and clinical applications of plates , screws and spinal segmental replacement implants made of this composite material have shown good results so far .", + "entities": [] + }, + { + "id": "3481", + "type": "gene", + "text": "In the absence of enhancer sequences , the adenovirus E1A gene can not stimulate CATase synthesis .", + "entities": [ + "adenovirus E1A gene", + "CATase" + ] + }, + { + "id": "3482", + "type": "gene", + "text": "At the same time , the results indicate that p53 plays a defensive role against HBV by transcriptionally repressing the HBV core promoter through liver - specific enhancer II and HBx is required to counteract this inhibitory function of p53 .", + "entities": [ + "p53", + "HBV core promoter", + "liver - specific enhancer II", + "HBx", + "p53" + ] + }, + { + "id": "3483", + "type": "gene", + "text": "This paper brings together data , obtained from a variety of sources , on the extent of prescription and use of psychotropic drugs in the late 1960s and early 1970s .", + "entities": [] + }, + { + "id": "3484", + "type": "gene", + "text": "Our results demonstrate that cis elements positioned between the alpha 3 and beta 4 coding regions are important for establishing part of the restricted CNS patterns of beta 4 , alpha 3 , and alpha 5 gene transcription .", + "entities": [ + "alpha 3", + "beta 4", + "beta 4", + "alpha 3", + "alpha 5 gene" + ] + }, + { + "id": "3485", + "type": "gene", + "text": "In vitro translation and in vivo polysome profile analysis indicated that transcripts C and E were translated with similar translational efficiencies that are substantially greater than that of transcript D , suggesting that 5 ' - untranslated regions play a role in translational control .", + "entities": [ + "transcripts C and E", + "transcript D" + ] + }, + { + "id": "3486", + "type": "gene", + "text": "Dsh is required for two different pathways , the Wnt pathway and planar polarity pathway in Drosophila .", + "entities": [ + "Dsh", + "Wnt" + ] + }, + { + "id": "3487", + "type": "gene", + "text": "When normalized for imaging time , all parameters are significantly higher with RASE , with a C / A per unit time that was 338 % higher .", + "entities": [] + }, + { + "id": "3488", + "type": "gene", + "text": "An in vitro binding site selection procedure was used to determine DNA sequences preferentially bound by wild - type HLF and chimeric E2A - HLF proteins isolated from various t ( 17 ; 19 ) - bearing leukemias .", + "entities": [ + "wild - type HLF", + "E2A", + "HLF" + ] + }, + { + "id": "3489", + "type": "gene", + "text": "First , the finding of a monomeric Alu family repeat at the junction between nonhomology block I and homology block Y of the alpha 2 gene - containing unit in rhesus macaque suggests that the dimeric Alu family repeat , Alu 3 , at the orthologous position in human was generated by insertion of a monomeric Alu family repeat into the 3 ' end of another preexisting Alu family repeat .", + "entities": [ + "Alu", + "alpha 2 gene - containing unit in rhesus macaque", + "Alu", + "Alu 3", + "Alu", + "Alu" + ] + }, + { + "id": "3490", + "type": "gene", + "text": "An E box element is required for the expression of the ad4bp gene , a mammalian homologue of ftz - f1 gene , which is essential for adrenal and gonadal development .", + "entities": [ + "ad4bp gene", + "mammalian homologue of ftz - f1 gene" + ] + }, + { + "id": "3491", + "type": "gene", + "text": "Sequence analysis revealed that in addition to the non - spliced variant , multiple mRNA species were generated by alternative splicing resulting in the exclusion of 92 , 166 , 170 , 174 and 263 nucleotides ( nt ) , respectively , from exon 1 .", + "entities": [] + }, + { + "id": "3492", + "type": "gene", + "text": "The majority of the cases with 0 - I or 0 - III components were sm . cancer .", + "entities": [] + }, + { + "id": "3493", + "type": "gene", + "text": "The role of ascorbic acid in the prevention of bladder tumor formation .", + "entities": [] + }, + { + "id": "3494", + "type": "gene", + "text": "Using the polymerase chain reaction , we analyzed the U6 RNA genes of 52 organisms .", + "entities": [ + "U6 RNA genes" + ] + }, + { + "id": "3495", + "type": "gene", + "text": "One missense allele ( P236S ) with complete loss of function at 30 degreesC and four missense alleles ( L173F , E225K , S269L and E274K ) that conferred a temperature sensitive phenotype were identified .", + "entities": [] + }, + { + "id": "3496", + "type": "gene", + "text": "A genomic clone was isolated that contained 12 . 5 kb of the 5 ' - flanking region and the first exon of the p69 / 71 2 - 5A synthetase gene .", + "entities": [ + "p69 / 71 2 - 5A synthetase gene" + ] + }, + { + "id": "3497", + "type": "gene", + "text": "ANIMALS : Fifty dogs with naturally developing DM .", + "entities": [] + }, + { + "id": "3498", + "type": "gene", + "text": "Polyclonal antibodies against the N - terminal part ( amino acids 12 - 363 ) and the C - terminal part ( amino acids 330 - 730 ) of rainbow trout HIF - 1alpha protein recognized rainbow trout and chinook salmon HIF - 1alpha protein in Western blot analysis .", + "entities": [ + "rainbow trout HIF - 1alpha protein", + "rainbow trout and chinook salmon HIF - 1alpha protein" + ] + }, + { + "id": "3499", + "type": "gene", + "text": "CNS effects of local anesthetics only partially dependent on biogenic amine mechanisms .", + "entities": [] + }, + { + "id": "3500", + "type": "gene", + "text": "Large T antigen was coimmunoprecipitated by antibodies to epitope - tagged TBP , endogenous TBP , hTAF ( II ) 100 , hTAF ( II ) 130 , and hTAF ( II ) 250 , under conditions where holo - TFIID would be precipitated .", + "entities": [ + "Large T antigen", + "TBP", + "TBP", + "hTAF ( II ) 100", + "hTAF ( II ) 130", + "hTAF ( II ) 250", + "holo - TFIID" + ] + }, + { + "id": "3501", + "type": "gene", + "text": "Replacing residues 405 - 419 on delta419 with the conserved AF - 2 domain from the vitamin D3 receptor or the estrogen receptor results in a receptor with wild - type or low transcriptional activity , respectively .", + "entities": [ + "vitamin D3 receptor", + "estrogen receptor" + ] + }, + { + "id": "3502", + "type": "gene", + "text": "In addition , media containing F beta alpha / CG beta displayed high - affinity binding to both CG and FSH receptors .", + "entities": [ + "F beta alpha", + "CG beta", + "CG and FSH receptors" + ] + }, + { + "id": "3503", + "type": "gene", + "text": "The downstream , TATA - less promoter has high G + C content , and exon 1b predominates among abundantly expressed mRNA species .", + "entities": [] + }, + { + "id": "3504", + "type": "gene", + "text": "Ask AONE ' s experts . . . about productivity indicators .", + "entities": [] + }, + { + "id": "3505", + "type": "gene", + "text": "Polyvinyl alcohol as a solution mediator", + "entities": [] + }, + { + "id": "3506", + "type": "gene", + "text": "Paroxysmal fluctuations in observed parasitemia in Plasmodium falciparum malaria .", + "entities": [] + }, + { + "id": "3507", + "type": "gene", + "text": "The C18 : 1 : C10 value is a convenient measure of these changes and can be determined more rapidly than determining all the lower fatty acids .", + "entities": [] + }, + { + "id": "3508", + "type": "gene", + "text": "The effect of a beta - adrenoceptor antagonist , pindolol , on uterine smooth muscle in term pregnant women was studied in vitro and in vivo ( in hypertensive women ) .", + "entities": [ + "beta - adrenoceptor" + ] + }, + { + "id": "3509", + "type": "gene", + "text": "Steroidogenic factor 1 , an orphan nuclear receptor , regulates the expression of the rat aromatase gene in gonadal tissues .", + "entities": [ + "Steroidogenic factor 1", + "orphan nuclear receptor", + "rat aromatase gene" + ] + }, + { + "id": "3510", + "type": "gene", + "text": "Site - directed mutagenesis of residues in this domain ( R82A , K85A , K88A , and V89A ) resulted in proteins which failed to transactivate from the HTLV - 1 LTR in vivo .", + "entities": [ + "HTLV - 1 LTR" + ] + }, + { + "id": "3511", + "type": "gene", + "text": "The 14 . 1 ( IGLL1 ) gene is expressed in a lineage - and stage - restricted manner .", + "entities": [ + "14 . 1 ( IGLL1 ) gene" + ] + }, + { + "id": "3512", + "type": "gene", + "text": "Nasal absorption was rapid , nasal bioavailability was 43 % , and the iv and nasal elimination profiles were similar .", + "entities": [] + }, + { + "id": "3513", + "type": "gene", + "text": "The level of contamination in the wound can be determined with the rapid biopsy fixation technique .", + "entities": [] + }, + { + "id": "3514", + "type": "gene", + "text": "Regulation of mitochondrial single - stranded DNA - binding protein gene expression links nuclear and mitochondrial DNA replication in drosophila .", + "entities": [] + }, + { + "id": "3515", + "type": "gene", + "text": "The influence of Epstein - Barr virus seropositivity on the efficacy of intravenous immune globulin in children with immune thrombocytopenic purpura .", + "entities": [ + "immune globulin" + ] + }, + { + "id": "3516", + "type": "gene", + "text": "These results indicate that evaluation of exposure to S . neurona by WB analysis of serum may be misleading in young horses .", + "entities": [] + }, + { + "id": "3517", + "type": "gene", + "text": "The prevalence of malnutrition was 30 % in the 47 patients without CVD and was significantly higher ( 70 % , P < 0 . 001 ) in the 70 patients with CVD , who also had lower tHcy , SAlb , plasma IGF - 1 , serum creatinine ( SCr ) , and blood hemoglobin .", + "entities": [ + "plasma IGF - 1", + "blood hemoglobin" + ] + }, + { + "id": "3518", + "type": "gene", + "text": "We demonstrated that , under serum - starved conditions , KMS - 11 and OPM - 2 cells express appreciable levels of phosphorylated FGFR3 mutants indicating a constitutive activation of the Y373C and K650E receptors ; the addition of the aFGF ligand further increased the level of receptor phosphorylation .", + "entities": [ + "FGFR3 mutants", + "Y373C and K650E receptors", + "aFGF ligand" + ] + }, + { + "id": "3519", + "type": "gene", + "text": "Isolation of a novel TP53 target gene from a colon cancer cell line carrying a highly regulated wild - type TP53 expression system .", + "entities": [ + "TP53 target gene", + "wild - type TP53" + ] + }, + { + "id": "3520", + "type": "gene", + "text": "The presence of locus - specific residues throughout the entire promoter region strongly suggests that the various HLA class I loci are differentially regulated .", + "entities": [ + "HLA class I loci" + ] + }, + { + "id": "3521", + "type": "gene", + "text": "Treatment and staining of smears and sections for detection of microorganisms", + "entities": [] + }, + { + "id": "3522", + "type": "gene", + "text": "The first transfusion resulted in a platelet increment to 32 Gpt / l ( CCI 11 ) .", + "entities": [] + }, + { + "id": "3523", + "type": "gene", + "text": "Tyrosine 1356 forms a multisubstrate binding site for the Grb2 and Shc adaptor proteins , the p85 subunit of phosphatidylinositol 3 ' - kinase , phospholipase Cgamma , and a phosphatase , SHP2 .", + "entities": [ + "Grb2", + "Shc adaptor proteins", + "p85 subunit", + "phosphatidylinositol 3 ' - kinase", + "phospholipase Cgamma", + "SHP2" + ] + }, + { + "id": "3524", + "type": "gene", + "text": "This is in contrast to PPARgamma2 , which was previously shown to be phosphorylated at a single site in a motif that is not homologous to the sites now described in PPARalpha .", + "entities": [ + "PPARgamma2", + "PPARalpha" + ] + }, + { + "id": "3525", + "type": "gene", + "text": "Seventeen of them were on treatment with systemic steroids .", + "entities": [] + }, + { + "id": "3526", + "type": "gene", + "text": "Nocodazole arrest of DU249 cells was exploited for the detection of an M - phase - activated MBP kinase that was resolved from p41 MAP kinase by phenyl - Superose chromatography .", + "entities": [ + "MBP kinase", + "p41 MAP kinase" + ] + }, + { + "id": "3527", + "type": "gene", + "text": "Cross reactivity in theophylline RIA kit decreased .", + "entities": [] + }, + { + "id": "3528", + "type": "gene", + "text": "SIM1 and SIM2 do not form homodimers , and they do not interact with AHR .", + "entities": [ + "SIM1", + "SIM2", + "AHR" + ] + }, + { + "id": "3529", + "type": "gene", + "text": "In contrast , the action of GLP - 1 at the CRE was not blocked by cotransfection with M1 - CREB , an isoform that lacks a consensus serine residue serving as substrate for PKA - mediated phosphorylation .", + "entities": [ + "GLP - 1", + "M1 - CREB", + "PKA" + ] + }, + { + "id": "3530", + "type": "gene", + "text": "Escherichia of a single sero - anzymatic type ( 06a6b : K13 : H1 ) were isolated in a group affection .", + "entities": [] + }, + { + "id": "3531", + "type": "gene", + "text": "Toxicity during the therapeutic period was not significant in the study group compared with the historical control , treated with the same regimen without G - CSF .", + "entities": [ + "G - CSF" + ] + }, + { + "id": "3532", + "type": "gene", + "text": "Strategic change in the NHS .", + "entities": [] + }, + { + "id": "3533", + "type": "gene", + "text": "Serum response factor ( SRF ) , a member of an ancient family of DNA - binding proteins , is generally assumed to be a ubiquitous transcription factor involved in regulating growth factor - responsive genes .", + "entities": [ + "Serum response factor", + "SRF" + ] + }, + { + "id": "3534", + "type": "gene", + "text": "Comments are given on the present status of regulations concerning water in swimming pools and baths - - 1991 - - ( in connection with the KOK regulations - - 1972 - - and the Federal German standard [ DIN ] No .", + "entities": [] + }, + { + "id": "3535", + "type": "gene", + "text": "This region includes verA , a structural gene previously shown to be required for ST biosynthesis , and 24 additional closely spaced transcripts ranging in size from 0 . 6 to 7 . 2 kb that are coordinately induced only under ST - producing conditions .", + "entities": [ + "verA" + ] + }, + { + "id": "3536", + "type": "gene", + "text": "Because of the increased CPK activity found in normal newborns , screening for Duchenne - type muscular dystrophy should be postponed for a few weeks after delivery .", + "entities": [ + "CPK" + ] + }, + { + "id": "3537", + "type": "gene", + "text": "The mRNA identified in both human and rat cells with the human clathrin clone revealed transcripts of approximately 6 . 5 kb , which is consistent with the predicted 180 kDa molecular weight of the clathrin heavy chain .", + "entities": [ + "human clathrin", + "clathrin heavy chain" + ] + }, + { + "id": "3538", + "type": "gene", + "text": "Development of a provisional information - retrieval descriptor language for \" Roentgenology and Medical Radiology \" for use in the Medinform system", + "entities": [] + }, + { + "id": "3539", + "type": "gene", + "text": "33 out of 90 neurons of the cat medial geniculate body revealed the selectivity of their afterdischarges to movement of sound when velocity of the movement changed from 30 to 180 deg / s .", + "entities": [] + }, + { + "id": "3540", + "type": "gene", + "text": "We conclude that at these low levels studied , aluminum accumulates in intestinal tissue , and that this accumulation is enhanced by citrate ligand .", + "entities": [] + }, + { + "id": "3541", + "type": "gene", + "text": "In the group of asthmatics statistically significant correlation was found between PC20 PGF2 alpha and histamine values ( r = 0 . 538 , p less than 0 . 05 ) .", + "entities": [] + }, + { + "id": "3542", + "type": "gene", + "text": "Suppression of food intake in the rat by tung oil .", + "entities": [] + }, + { + "id": "3543", + "type": "gene", + "text": "A 1 . 8 - kb cDNA clone ( designed hKID , gene symbol AQP2L ) with homology to the aquaporins was isolated from a human kidney cDNA library .", + "entities": [ + "hKID", + "gene symbol AQP2L", + "aquaporins" + ] + }, + { + "id": "3544", + "type": "gene", + "text": "The protein encoded by ORF113 contains a transmembrane domain .", + "entities": [ + "ORF113" + ] + }, + { + "id": "3545", + "type": "gene", + "text": "Transcriptional regulation of fbp1 promoter constructs containing only UAS1 or UAS2 confirms that the PKA and MAPK regulation is targeted to both sites .", + "entities": [ + "fbp1 promoter constructs", + "PKA", + "MAPK" + ] + }, + { + "id": "3546", + "type": "gene", + "text": "3 cases", + "entities": [] + }, + { + "id": "3547", + "type": "gene", + "text": "Functional analysis of the mutant desmin in SW13 ( vim - ) cells showed aggregation of abnormal coarse clumps of desmin positive material dispersed throughout the cytoplasm .", + "entities": [ + "mutant desmin", + "vim", + "desmin" + ] + }, + { + "id": "3548", + "type": "gene", + "text": "The antibody titer of 202 chickens to SA - 11 rotavirus was determined by enzyme - linked immunosorbent blocking assay .", + "entities": [] + }, + { + "id": "3549", + "type": "gene", + "text": "OBJECTIVE : Our goal was to determine whether chlamydia - infected women have a higher rate of febrile complications after postpartum tubal ligation .", + "entities": [] + }, + { + "id": "3550", + "type": "gene", + "text": "To study the significance of these domains and the overall evolutionary conservation of the gene , the homolog from Drosophila melanogaster was isolated by low stringency hybridizations using two flanking probes of the human ERCC3 cDNA .", + "entities": [ + "human ERCC3 cDNA" + ] + }, + { + "id": "3551", + "type": "gene", + "text": "Results confirmed that stress produced CA3 dendritic atrophy and tianeptine prevented it .", + "entities": [] + }, + { + "id": "3552", + "type": "gene", + "text": "In 49 patients in whom gated equilibrium ventriculography and cardiac catheterization were performed within a 6 day interval , total and fractional portions of global and regional right ventricular ejection fraction ( RVEF ) were correlated with pulmonary arterial systolic pressure .", + "entities": [] + }, + { + "id": "3553", + "type": "gene", + "text": "The epitope - protected lysine ( K ) was present in a 30 - aa TPO fragment that , by N - terminal sequencing , was found to be K713 .", + "entities": [ + "30 - aa TPO fragment" + ] + }, + { + "id": "3554", + "type": "gene", + "text": "Special issues devoted to the biosynthesis of woody plant biopolymers and related substances .", + "entities": [] + }, + { + "id": "3555", + "type": "gene", + "text": "TaV particles have a buoyant density of 1 . 296 g / cm3 in CsCl and consist of two capsid proteins of 56 and 6 kDa .", + "entities": [ + "capsid proteins" + ] + }, + { + "id": "3556", + "type": "gene", + "text": "Adult H , but not R , manifested the burrowing preference whenever offered the opportunity .", + "entities": [] + }, + { + "id": "3557", + "type": "gene", + "text": "Plasma renin concentration is significantly higher in the subcapsular venous outflow , which drains the superficial cortex , than in the deep venous outflow , which drains the inner half of the cortex and medulla of the cat kidney .", + "entities": [ + "Plasma renin" + ] + }, + { + "id": "3558", + "type": "gene", + "text": "No ISREs could be identified in the mouse promoter .", + "entities": [ + "ISREs" + ] + }, + { + "id": "3559", + "type": "gene", + "text": "Papers of the Society for Clinical Vascular Surgery .", + "entities": [] + }, + { + "id": "3560", + "type": "gene", + "text": "Serum amylase became markedly elevated ( 2 , 624 CU / 100 ml ) , as did the serum FFA ( 29 . 19 mEq / liter ) .", + "entities": [ + "Serum amylase" + ] + }, + { + "id": "3561", + "type": "gene", + "text": "RESULTS : Of the 24 patients , 6 had Grade 1 pneumonitis , and 13 had Grade 2 pneumonitis .", + "entities": [] + }, + { + "id": "3562", + "type": "gene", + "text": "The human p100 protein was recently identified as a coactivator of the Epstein - Barr virus nuclear antigen 2 .", + "entities": [ + "human p100 protein", + "Epstein - Barr virus nuclear antigen 2" + ] + }, + { + "id": "3563", + "type": "gene", + "text": "There were 3 / 32 ( 9 . 4 per cent ) adverse reactions ( ADRs ) , and one case each of nausea , dizziness and increased menstrual flow .", + "entities": [] + }, + { + "id": "3564", + "type": "gene", + "text": "Ultrastructural studies of retinopathy of premature infants", + "entities": [] + }, + { + "id": "3565", + "type": "gene", + "text": "The genes encoding the transcription factor yTAFII60 , the G4p1 protein and a putative glucose transporter are contained in a 12 . 3 kb DNA fragment on the left arm of Saccharomyces cerevisiae chromosome VII .", + "entities": [ + "transcription factor yTAFII60", + "G4p1 protein" + ] + }, + { + "id": "3566", + "type": "gene", + "text": "Fetal lung volume : estimation at MR imaging - initial results .", + "entities": [] + }, + { + "id": "3567", + "type": "gene", + "text": "A constitutive allele of GPA2 could stimulate growth of a strain lacking both RAS genes .", + "entities": [ + "GPA2", + "RAS genes" + ] + }, + { + "id": "3568", + "type": "gene", + "text": "Finally , we determined that the P68 amino terminus was both necessary and sufficient for binding dsRNA as we were able to transfer dsRNA - binding properties to a reporter gene product previously unable to bind RNA .", + "entities": [ + "P68" + ] + }, + { + "id": "3569", + "type": "gene", + "text": "Urological complications are frequent during and after the treatment of gynecological malignancy .", + "entities": [] + }, + { + "id": "3570", + "type": "gene", + "text": "The following technique describes a modification to a bar superstructure that provided the advantages of convenience , security , and consistent positioning even though one implant was lost and the angulation of implants limited accuracy .", + "entities": [] + }, + { + "id": "3571", + "type": "gene", + "text": "To characterize the O7 - LPS region , the recombinant cosmids pJHCV31 and pJHCV32 were mutagenized by transposon mutagenesis with Tn3HoHo1 , which carries a promoterless lac operon and can therefore generate lacZ transcriptional fusions with target DNA sequences .", + "entities": [ + "O7 - LPS region", + "Tn3HoHo1", + "lac operon", + "lacZ" + ] + }, + { + "id": "3572", + "type": "gene", + "text": "Disulfiram and the drug - induced effects on motility .", + "entities": [] + }, + { + "id": "3573", + "type": "gene", + "text": "Tendon also shows a degree of extensibility .", + "entities": [] + }, + { + "id": "3574", + "type": "gene", + "text": "These observations have led us to conclude that an elevated VIII - ratio is a very sensitive indicator of intravascular coagulation .", + "entities": [] + }, + { + "id": "3575", + "type": "gene", + "text": "This study was undertaken to define the mechanism for the respiratory inhibition observed during high - frequency oscillatory ventilation ( HFOV ) .", + "entities": [] + }, + { + "id": "3576", + "type": "gene", + "text": "In controls , only modest differences were observed .", + "entities": [] + }, + { + "id": "3577", + "type": "gene", + "text": "Three mutants were isolated from the widely used strain , PAO1 .", + "entities": [] + }, + { + "id": "3578", + "type": "gene", + "text": "A coiled - coil related protein specific for synapsed regions of meiotic prophase chromosomes .", + "entities": [ + "coiled - coil related protein" + ] + }, + { + "id": "3579", + "type": "gene", + "text": "In group I adults both of these variables increased .", + "entities": [] + }, + { + "id": "3580", + "type": "gene", + "text": "Alignment of the selected sequences allowed us to predict a consensus sequence for binding of the individual homodimeric Rel - related proteins , and DNA - protein binding analysis of the selected DNA sequences revealed sequence specificity of the proteins .", + "entities": [ + "Rel - related proteins" + ] + }, + { + "id": "3581", + "type": "gene", + "text": "We have previously isolated a cDNA for a transcription factor referred to as Zfhep ( zinc finger homeodomain enhancer - binding protein ) containing two separate zinc finger domains , ZD1 and ZD2 , each of which binds DNA , and a homeodomain .", + "entities": [ + "Zfhep", + "zinc finger homeodomain enhancer - binding protein", + "ZD1", + "ZD2" + ] + }, + { + "id": "3582", + "type": "gene", + "text": "No apparent clinical signs indicative of systemic toxicity were observed in the F0 and F1 animals of either sex .", + "entities": [] + }, + { + "id": "3583", + "type": "gene", + "text": "Once NGF administration is proven effective it will be possible to develop alternative ways of NGF administration .", + "entities": [ + "NGF", + "NGF" + ] + }, + { + "id": "3584", + "type": "gene", + "text": "Mutating the Fcp1p - binding motif KEFGK in the RAP74 ( Tfg1p ) subunit of TFIIF to EEFGE led to both synthetic phenotypes in certain fcp1 tfg1 double mutants and a reduced ability of Fcp1p to activate transcription when it is artificially tethered to a promoter .", + "entities": [ + "Fcp1p", + "RAP74", + "Tfg1p", + "TFIIF", + "tfg1", + "Fcp1p" + ] + }, + { + "id": "3585", + "type": "gene", + "text": "We conclude that sequences outside of the hLEF HMG box mediate cell - and context - specific activation of the TCR alpha enhancer and may facilitate interactions between hLEF and other T - cell - specific factors recruited to the enhancer .", + "entities": [ + "hLEF HMG box", + "TCR alpha enhancer", + "hLEF" + ] + }, + { + "id": "3586", + "type": "gene", + "text": "Therapeutic effects of cefpirome ( HR 810 ) on experimental mixed infections with Enterococcus faecalis and Escherichia coli in mice .", + "entities": [] + }, + { + "id": "3587", + "type": "gene", + "text": "The intracellular basic region / helix - loop - helix ( bHLH ) dioxin receptor mediates signal transduction by dioxin ( 2 , 3 , 7 , 8 - tetrachlorodibenzo - p - dioxin ) and functions as a ligand - activated DNA binding protein directly interacting with target genes by binding to dioxin response elements .", + "entities": [ + "basic region / helix - loop - helix ( bHLH ) dioxin receptor" + ] + }, + { + "id": "3588", + "type": "gene", + "text": "Therefore , it was concluded that thrombotic tendency certainly existed in patients with MS compared to those with non RHD and that it was one of the causes of the significantly high incidence of thromboembolism in comparison with non RHD .", + "entities": [] + }, + { + "id": "3589", + "type": "gene", + "text": "In the matched control group the acquisition - rate of both symptomatic and asymptomatic 0acteriuria was over 12 % , a figure similar to the percentage of women present in the practice population during one year with transient , symptomatic , and persistent A . B .", + "entities": [] + }, + { + "id": "3590", + "type": "gene", + "text": "Also , the BALB / c gene contains a single substitution in a conserved octamer sequence approximately equal to 100 nucleotides upstream of the coding region , which could affect its expression .", + "entities": [ + "BALB / c gene" + ] + }, + { + "id": "3591", + "type": "gene", + "text": "The cellular part of the third chimeric clone shows significant homology to an exon of the human tyrosine phosphatase 1 gene , although oriented in the antisense direction compared to the adjacent LTR .", + "entities": [ + "human tyrosine phosphatase 1 gene" + ] + }, + { + "id": "3592", + "type": "gene", + "text": "A survey is given of the pharmacological backgrounds that are relevant for the drug treatment of essential hypertension in the elderly .", + "entities": [] + }, + { + "id": "3593", + "type": "gene", + "text": "The expression analysis of the KlHIS4 gene under phosphate starvation or high adenine supply shows that factors , such as Bas1 or Bas2 , involved in the basal control may also operate in a different way in K . lactis .", + "entities": [ + "KlHIS4 gene", + "Bas1", + "Bas2" + ] + }, + { + "id": "3594", + "type": "gene", + "text": "The method is applied to determine aberration constants of a CM300 FEG / UT microscope with correction of the three - fold astigmatism .", + "entities": [] + }, + { + "id": "3595", + "type": "gene", + "text": "The tetraphasic action of lidocaine on CNS electrical activity and behavior in cats .", + "entities": [] + }, + { + "id": "3596", + "type": "gene", + "text": "L . , Stange , G . , Markovich , D . , Biber , J . , Testar , X . , Zorzano , A . , Palacin , M . , and Murer , H .", + "entities": [] + }, + { + "id": "3597", + "type": "gene", + "text": "No significant correlations of peak VO2 were observed between the 3 tests .", + "entities": [] + }, + { + "id": "3598", + "type": "gene", + "text": "Abstracts .", + "entities": [] + }, + { + "id": "3599", + "type": "gene", + "text": "Next , to identify regions of the promoter involved , we examined a series of tenascin - C promoter constructs with 5 ' deletions and showed that denatured collagen - dependent promoter activity was retained by a 122 - base pair element , located - 43 to - 165 bp upstream of the RNA start site .", + "entities": [ + "tenascin - C promoter constructs", + "collagen - dependent promoter" + ] + }, + { + "id": "3600", + "type": "gene", + "text": "Inhibition of constitutive NF - kappaB activity results in cell death of TT cells and blocks focus formation induced by oncogenic forms of RET in NIH 3T3 cells .", + "entities": [ + "NF - kappaB", + "RET" + ] + }, + { + "id": "3601", + "type": "gene", + "text": "The MRS II meets a high methodological standard as an instrument standardized in the population .", + "entities": [] + }, + { + "id": "3602", + "type": "gene", + "text": "Doppler ultrasound studies of long - term follow - up of children with hemolytic - uremic syndrome", + "entities": [] + }, + { + "id": "3603", + "type": "gene", + "text": "Diagnosis and treatment of insulin - secreting tumours .", + "entities": [ + "insulin" + ] + }, + { + "id": "3604", + "type": "gene", + "text": "Endocytosis and vacuolar degradation of the plasma membrane - localized Pdr5 ATP - binding cassette multidrug transporter in Saccharomyces cerevisiae .", + "entities": [ + "Pdr5 ATP - binding cassette multidrug transporter" + ] + }, + { + "id": "3605", + "type": "gene", + "text": "Recent investigations have shown that Grenz rays can suppress the allergic contact dermatitis reaction completely and that Langerhans cells , identified by OKT6 antibodies and electron microscopy , disappear from the epidermis at the same time .", + "entities": [ + "OKT6 antibodies" + ] + }, + { + "id": "3606", + "type": "gene", + "text": "Mesial temporal sclerosis was characterized by severe neuronal loss accompanied by gliosis occurring in the CA1 / prosubiculum ( 27 patients , 100 % ) , focally in the dentate gyrus ( 12 patients , 44 % ) , and in the CA4 region ( 11 patients , 41 % ) .", + "entities": [] + }, + { + "id": "3607", + "type": "gene", + "text": "In the commercially available intravenous formulation of Cyclosporin A ( Sandimmun ) , polyoxyethylated castor oil ( Cremophor EL ) is used as a solubilizing agent .", + "entities": [] + }, + { + "id": "3608", + "type": "gene", + "text": "By using interleukin - 3 - dependent cells that ectopically express the three ErbB proteins or their combinations , we found that ErbB - 3 is devoid of any biological activity but both ErbB - 1 and ErbB - 2 can reconstitute its extremely potent mitogenic activity .", + "entities": [ + "interleukin - 3", + "ErbB proteins", + "ErbB - 3", + "ErbB - 1", + "ErbB - 2" + ] + }, + { + "id": "3609", + "type": "gene", + "text": "In an effort to separate domains of FadR required for DNA binding , dimerization , and ligand binding , chimeric protein fusions between the DNA binding domain of LexA and different regions of FadR were constructed .", + "entities": [ + "FadR", + "LexA", + "FadR" + ] + }, + { + "id": "3610", + "type": "gene", + "text": "After phosphorylation , STAT proteins are transported into the nucleus and exhibit transcriptional activity .", + "entities": [ + "STAT proteins" + ] + }, + { + "id": "3611", + "type": "gene", + "text": "The protein encoded by the fruA transcript is well conserved with the D . melanogaster type A protein , particularly the BTB protein - protein - binding domain , which is encoded by exons I and II and is 100 % conserved .", + "entities": [ + "fruA transcript", + "D . melanogaster type A protein", + "BTB protein" + ] + }, + { + "id": "3612", + "type": "gene", + "text": "The mortality rate and histopathological features of Nocardia asteroides and Nocardia brasiliensis infections in congenitally athymic ( nude ) mice of ICR and C3H / eB origins were quite different from what we found for Swiss white mice and other inbred mouse strains ( namely , C57 / BL / 6J , New Zealand Black , BALB / c , CBA / LAC , and C3H / eB ) .", + "entities": [] + }, + { + "id": "3613", + "type": "gene", + "text": "This E box sequence ( CACGTG ) is identical to the binding element for USF ( upstream stimulatory factor ) , a member of the helix - loop - helix family of transcription factors .", + "entities": [ + "USF", + "upstream stimulatory factor", + "helix - loop - helix family of transcription factors" + ] + }, + { + "id": "3614", + "type": "gene", + "text": "Our findings provide the first evidence that the function of WT1 can be modulated by its phosphorylation in vivo .", + "entities": [ + "WT1" + ] + }, + { + "id": "3615", + "type": "gene", + "text": "Efficacy of a three - versus a five - week alcohol treatment program .", + "entities": [] + }, + { + "id": "3616", + "type": "gene", + "text": "A transparent overlay for assessing amplitude of ECG wave forms .", + "entities": [] + }, + { + "id": "3617", + "type": "gene", + "text": "Studies using a reporter plasmid with a functionally disrupted sterol - responsive element ( SRE ) - 1 revealed a reduced stimulatory response to IL - 6 .", + "entities": [ + "IL - 6" + ] + }, + { + "id": "3618", + "type": "gene", + "text": "Interestingly , however , it is homologous to several expressed sequence tags ( EST ) of unknown function from Caenorhabditis elegans , Oryza sativa and Homo sapiens .", + "entities": [] + }, + { + "id": "3619", + "type": "gene", + "text": "Among these are : ( 1 ) Is there sufficient understanding of family pathophysiology , of the sensitivity and specificity of diagnostic techniques and of the safety and efficacy of therapeutic modalities to make true family health care possible ?", + "entities": [] + }, + { + "id": "3620", + "type": "gene", + "text": "( 2 ) If this type of care is possible , how are the needs of the family and its individual members met , or value judgements made about their relative importance ? and ( 3 ) What are the consequences for the health care delivery system of this type of care ?", + "entities": [] + }, + { + "id": "3621", + "type": "gene", + "text": "An extensive literature review is used in an attempt to answer these queries , from which questions for further study are posed .", + "entities": [] + }, + { + "id": "3622", + "type": "gene", + "text": "The short - term synthesis and infant - regulated removal of milk in lactating women .", + "entities": [] + }, + { + "id": "3623", + "type": "gene", + "text": "To explore the mechanism of RSK activation , a cloned human RSK cDNA ( RSK3 ) was used to generate and characterize several site - directed RSK mutants ; K91A ( N - Lys , NH2 - terminal ATP - binding mutant ) , K444A ( C - Lys , COOH - terminal ATP - binding mutant ) , N / C - Lys ( double ATP - binding mutant ) T570A ( C - Thr , mutant of the putative MAPK phosphorylation site in subdomain VIII of the C - domain ) , S218A ( N - Ser , mutant of the corresponding NH2 - terminal residue ) .", + "entities": [ + "RSK", + "RSK", + "RSK3", + "RSK mutants", + "MAPK" + ] + }, + { + "id": "3624", + "type": "gene", + "text": "Characterization of a Xenopus laevis CXC chemokine receptor 4 : implications for hematopoietic cell development in the vertebrate embryo .", + "entities": [ + "Xenopus laevis CXC chemokine receptor 4" + ] + }, + { + "id": "3625", + "type": "gene", + "text": "DNase I footprinting with rat liver nuclear extracts identified 7 major protein - binding domains termed P1 through P7 in a 796 base pair DNA fragment ( base pairs - 763 to + 33 ) .", + "entities": [ + "DNase I" + ] + }, + { + "id": "3626", + "type": "gene", + "text": "In some of the cases of solitary lesion , serum TSH levels , serum thyroglobulin values , and 131I protein bounded iodine ( 131I - PBI ) were measured , but there were no significant differences between successful and unsuccessful therapy .", + "entities": [ + "serum TSH", + "serum thyroglobulin" + ] + }, + { + "id": "3627", + "type": "gene", + "text": "Marked sedative activity was observed with 9 - methoxy - 5 - phenylpyrrolo [ 2 , 1 - d ] [ 1 , 5 ] benzothiazepin - 6 , 6 - dioxide ( NF19 ) and 9 - chloro - 5 - p - nitrophenylpyrrolo [ 2 , 1 - d ] [ 1 , 5 ] benzothiazepin - 6 , 6 - dioxide ( NF20 ) .", + "entities": [] + }, + { + "id": "3628", + "type": "gene", + "text": "Patients with moderate PDDAT were impaired on all serial positions for both spatial order and spatial recognition memory .", + "entities": [] + }, + { + "id": "3629", + "type": "gene", + "text": "Subdural electrodes may yield larger VEP amplitudes than skull or scalp electrodes .", + "entities": [] + }, + { + "id": "3630", + "type": "gene", + "text": "To gain insight into the possible involvement of p21 in liver cell growth , the expression and regulation of the p21 gene was evaluated in rodent models of liver regeneration and specimens of human liver diseases .", + "entities": [ + "p21", + "p21 gene" + ] + }, + { + "id": "3631", + "type": "gene", + "text": "The mature chromosome 4 FRG1 transcript is 1042 bp in length and contains nine exons which encode a putative protein of 258 amino acid residues .", + "entities": [ + "FRG1 transcript" + ] + }, + { + "id": "3632", + "type": "gene", + "text": "In untransformed cells , three major proteins coprecipitated with CRKL , identified as C3G , SOS and c - ABL .", + "entities": [ + "CRKL", + "C3G", + "SOS", + "c - ABL" + ] + }, + { + "id": "3633", + "type": "gene", + "text": "Application of different criteria of cure revealed that 19 patients ( 66 % ) had basal GH levels below 5 ng / ml , 17 patients ( 59 % ) had normal somatomedin - C values , 16 patients ( 55 % ) had complete GH suppression ( less than 1 ng / ml ) during OGTT , and 13 patients ( 45 % ) met the above - mentioned criteria with disappearance of the paradoxical GH response to TRH / GnRH test .", + "entities": [ + "GH", + "somatomedin - C", + "GH", + "GH", + "TRH", + "GnRH" + ] + }, + { + "id": "3634", + "type": "gene", + "text": "The 5 ' external transcribed spacer ( ETS ) region of the pre - rRNA in Saccharomyces cerevisiae contains a sequence with 10 bp of perfect complementarity to the U3 snoRNA .", + "entities": [ + "U3 snoRNA" + ] + }, + { + "id": "3635", + "type": "gene", + "text": "Experimental study of ta chengchi tang decoction for relieving lung injury during acute necrotizing pancreatitis ] The objectives of the study were to investigate the changes of leukocyte adhesiveness and tumor necrosis factor ( TNF ) in the early stage of acute necrotizing pancreatitis ( ANP ) , to go further into the relation of those changes to lung injury of ANP , and to evaluate the prohibitive effect of ta chengchi tang Decoction on leukocyte adhesion and TNF secretion .", + "entities": [ + "tumor necrosis factor", + "TNF", + "TNF" + ] + }, + { + "id": "3636", + "type": "gene", + "text": "The mean serum creatinine level did not change during the first 6 months after withdrawal of MMF .", + "entities": [] + }, + { + "id": "3637", + "type": "gene", + "text": "These findings suggest that a range of microenvironmental conditions exist within purified water systems , leading to variable populations of bacteria .", + "entities": [] + }, + { + "id": "3638", + "type": "gene", + "text": "I .", + "entities": [] + }, + { + "id": "3639", + "type": "gene", + "text": "Nursing of patients with gynecological diseases", + "entities": [] + }, + { + "id": "3640", + "type": "gene", + "text": "Here , we report the complete structure of the human topoisomerase IIalpha gene , which consists of 35 exons spanning 27 . 5 kb .", + "entities": [ + "human topoisomerase IIalpha gene" + ] + }, + { + "id": "3641", + "type": "gene", + "text": "METHODS : We retrospectively selected 13 TFCD patients who underwent surgery for intractable epilepsy with the aim of removing the magnetic resonance ( MR ) - detectable lesion and / or the epileptogenic zone defined by stereoelectroencephalographic recordings .", + "entities": [] + }, + { + "id": "3642", + "type": "gene", + "text": "The protein expressed by F2771 cDNA in transfected COS cells is localized in the cytoplasm .", + "entities": [ + "F2771 cDNA" + ] + }, + { + "id": "3643", + "type": "gene", + "text": "Although elevated serum levels of antibodies to the nicotinic acetylcholine receptor ( nAChR ) have been reported in neuroleptic treated patients with tardive dyskinesia , such antibodies have not been determined in comparable nondyskinetic patients .", + "entities": [ + "nicotinic acetylcholine receptor", + "nAChR" + ] + }, + { + "id": "3644", + "type": "gene", + "text": "An end - to - end pancreaticojejunostomy using a mechanical purse - string device .", + "entities": [] + }, + { + "id": "3645", + "type": "gene", + "text": "Molecular mimicry of human cytokine and cytokine response pathway genes by KSHV .", + "entities": [] + }, + { + "id": "3646", + "type": "gene", + "text": "Stimulation of the caudate nucleus ' dophamine - reactive system in dogs by means of administration of dophamine ( 60 micrograms ) and phenamine led to deterioration of conditioned and unconditioned components of feeding behaviour .", + "entities": [] + }, + { + "id": "3647", + "type": "gene", + "text": "Although the fertility decline in the black population in the Mississippi Delta between the late 1870 ' s and early 1930 ' s closely paralleled that of the national black population , it rose much more dramatically in the 1940 ' s and 1950 ' s to almost 1880 levels .", + "entities": [] + }, + { + "id": "3648", + "type": "gene", + "text": "In this report , we investigate the mechanism underlying Ras activation upon stimulation of these two types of receptors in hematopoietic cells .", + "entities": [ + "Ras" + ] + }, + { + "id": "3649", + "type": "gene", + "text": "The lengths of the complete polypeptide chain of the recombinant enzyme and its transit peptide are 388 and 53 residues , respectively .", + "entities": [] + }, + { + "id": "3650", + "type": "gene", + "text": "Immunochemotherapy with schizophyllan ( SPG ) combined with chemotherapeutic agents was evaluated in two syngeneic tumor - C3H / He mouse systems .", + "entities": [] + }, + { + "id": "3651", + "type": "gene", + "text": "HuEpo - R Ab inhibited Epo - induced parental UT - 7 cell growth , but not that of cells of clone 12 , suggesting that the muEpo - R is able to induce human UT - 7 cell proliferation .", + "entities": [ + "HuEpo - R Ab", + "Epo", + "muEpo - R" + ] + }, + { + "id": "3652", + "type": "gene", + "text": "Ligation of CD40 rescues Ramos - Burkitt lymphoma B cells from calcium ionophore - and antigen receptor - triggered apoptosis by inhibiting activation of the cysteine protease CPP32 / Yama and cleavage of its substrate PARP .", + "entities": [ + "CD40", + "CPP32", + "Yama", + "PARP" + ] + }, + { + "id": "3653", + "type": "gene", + "text": "The unique nature and arrangement of the ANT1 transcriptional control elements may account for this differential expression .", + "entities": [ + "ANT1 transcriptional control elements" + ] + }, + { + "id": "3654", + "type": "gene", + "text": "G - CSF activates multiple signaling molecules , including the JAK1 and JAK2 kinases and the STAT transcription factors .", + "entities": [ + "G - CSF", + "JAK1", + "JAK2 kinases", + "STAT" + ] + }, + { + "id": "3655", + "type": "gene", + "text": "The strategy has been used to determine 2 . 6 kilobases of nucleotide sequence in the Saccharomyces cerevisiae ADE 1 locus .", + "entities": [ + "Saccharomyces cerevisiae ADE 1 locus" + ] + }, + { + "id": "3656", + "type": "gene", + "text": "In analyses with control for multiple variables , relative risk for microalbuminuria ( urinary albumin excretion , 20 - 199 microg / min ) in men and women was 2 . 51 and 1 . 62 , respectively , with 18 mm Hg higher ( 1 SD ) systolic blood pressure ; 2 . 25 and 2 . 10 , respectively , with 1 . 0 - mmol / L ( 40 mg / dL ) higher plasma cholesterol level ; 1 . 99 and 1 . 91 , respectively , for smokers vs nonsmokers ; and 1 . 83 and 1 . 33 , respectively , with 4 kg / m2 higher body mass index .", + "entities": [ + "albumin" + ] + }, + { + "id": "3657", + "type": "gene", + "text": "Among 38 patients with inducible reentrant VTs who underwent electrophysiologic study ( EPS ) , 10 VTs of six patients were selected .", + "entities": [] + }, + { + "id": "3658", + "type": "gene", + "text": "EXERCISE IN THE TERRESTRIAL CHRISTMAS ISLAND RED CRAB GECARCOIDEA NATALIS - ENERGETICS OF LOCOMOTION", + "entities": [] + }, + { + "id": "3659", + "type": "gene", + "text": "Purification of MvaT enriched for two polypeptides of approximate molecular mass 15 kDa and 16 kDa , designated P15 and P16 .", + "entities": [ + "MvaT", + "P15", + "P16" + ] + }, + { + "id": "3660", + "type": "gene", + "text": "Immediately before surgery patients received either intravenous hydrocortisone 100 mg or placebo in random , double - blind order .", + "entities": [] + }, + { + "id": "3661", + "type": "gene", + "text": "ZK7 and HZF16 genes appear to be the splice variants transcribed from the same gene .", + "entities": [ + "ZK7", + "HZF16 genes" + ] + }, + { + "id": "3662", + "type": "gene", + "text": "This Mr is similar to those of the purified smg p25A GDI estimated by sodium dodecyl sulfate - polyacrylamide gel electrophoresis and sucrose density gradient ultracentrifugation , which are about 54 , 000 and 65 , 000 , respectively .", + "entities": [ + "purified smg p25A GDI" + ] + }, + { + "id": "3663", + "type": "gene", + "text": "Administration of growth hormone leads to faster growth , but also faster bone maturation .", + "entities": [ + "growth hormone" + ] + }, + { + "id": "3664", + "type": "gene", + "text": "Recurrent G - to - A substitution in a single codon of SREBP cleavage - activating protein causes sterol resistance in three mutant Chinese hamster ovary cell lines .", + "entities": [ + "SREBP cleavage - activating protein" + ] + }, + { + "id": "3665", + "type": "gene", + "text": "Whereas a PR55 beta transcript of about 2 . 3 kb was detected at high levels in the neuroblastoma derived cell line LA - N - 1 , the level of the mRNA was very low in the other human cell lines analyzed .", + "entities": [ + "PR55 beta transcript" + ] + }, + { + "id": "3666", + "type": "gene", + "text": "Thus , the P . aeruginosa orfX and vfr promoters are arranged in a back - to - back orientation rather than the face - to - face orientation of the dorf and crp promoters .", + "entities": [ + "vfr promoters", + "crp promoters" + ] + }, + { + "id": "3667", + "type": "gene", + "text": "The C4BP alpha gene is organized as follows : the first exon codes for the first 198 nucleotides of the 5 ' UTR .", + "entities": [ + "C4BP alpha gene" + ] + }, + { + "id": "3668", + "type": "gene", + "text": "These regions may be differentially involved in tissue - specificity , and / or circadian regulation , of the human hPer1 gene transcription .", + "entities": [ + "human hPer1 gene" + ] + }, + { + "id": "3669", + "type": "gene", + "text": "Studying intracellular signaling pathways , which may be involved in malignant transformation of Ret - 9bp expressing NIH3T3 cells , we could demonstrate Ret - 9bp dependent phosphorylation of insulin receptor substrate - 2 ( IRS - 2 ) with consecutive activation of phosphatidylinositol 3 - kinase ( PI 3 - kinase ) and protein kinase B ( PKB / AKT ) .", + "entities": [ + "Ret - 9bp", + "Ret - 9bp", + "insulin receptor substrate - 2", + "IRS - 2", + "phosphatidylinositol 3 - kinase", + "PI 3 - kinase", + "protein kinase B", + "PKB", + "AKT" + ] + }, + { + "id": "3670", + "type": "gene", + "text": "It is the human homolog of the mouse Mx protein involved in resistance to influenza virus .", + "entities": [ + "mouse Mx protein" + ] + }, + { + "id": "3671", + "type": "gene", + "text": "In the single case the restoration of a structured daily routine represents the presupposition for a cognitive therapy .", + "entities": [] + }, + { + "id": "3672", + "type": "gene", + "text": "The effect of echothiophate on the biphasic response of rabbit ocular pressure to dipivefrin .", + "entities": [] + }, + { + "id": "3673", + "type": "gene", + "text": "We have subcloned into pBR322 deoxyribonucleic acid ( DNA ) sequences mapping either in the coding region , the 5 ' spacer , or the 3 ' spacer of the H2B histone gene .", + "entities": [ + "H2B histone gene" + ] + }, + { + "id": "3674", + "type": "gene", + "text": "The role of the Vp1 DBD during infection was investigated by taking advantage of NLS phenotypic complementation ( N .", + "entities": [ + "Vp1 DBD" + ] + }, + { + "id": "3675", + "type": "gene", + "text": "In the artificial lung , like in the natural lung and peripheral tissues , gas exchanges depend on several parameters : blood inlet conditions , blood flow rate , temperature , composition of the gas mixture used for ventilation , blood tissue perfusion , O2 consumption , etc .", + "entities": [] + }, + { + "id": "3676", + "type": "gene", + "text": "Cortical dysplasias , genetics , and epileptogenesis .", + "entities": [] + }, + { + "id": "3677", + "type": "gene", + "text": "BACKGROUND / PURPOSE : Anomalous arrangement of the pancreaticobiliary duct ( AAPBD ) is closely related to congenital biliary dilatation and frequently associated with biliary tract malignancy .", + "entities": [] + }, + { + "id": "3678", + "type": "gene", + "text": "Mouse mast cell protease 9 , a novel member of the chromosome 14 family of serine proteases that is selectively expressed in uterine mast cells .", + "entities": [ + "Mouse mast cell protease 9", + "serine proteases" + ] + }, + { + "id": "3679", + "type": "gene", + "text": "The v - Src SH3 domain facilitates a cell adhesion - independent association with focal adhesion kinase .", + "entities": [ + "SH3 domain", + "focal adhesion kinase" + ] + }, + { + "id": "3680", + "type": "gene", + "text": "Co - immunoprecipitation and DNA affinity chromatography prove that Sp1 heterodimerizes with ZBP - 89 when bound to the silencer element to yield a DNA - protein complex whose mobility is indistinguishable from that displayed by HeLa nuclear extract in band shift assays .", + "entities": [ + "Sp1", + "ZBP - 89" + ] + }, + { + "id": "3681", + "type": "gene", + "text": "Mucolipidosis type IV : clinical spectrum and natural history .", + "entities": [] + }, + { + "id": "3682", + "type": "gene", + "text": "It has been proposed that the parCBA operon encodes a plasmid partitioning system ( M .", + "entities": [ + "parCBA operon" + ] + }, + { + "id": "3683", + "type": "gene", + "text": "Albumin and cyclic AMP levels in peritoneal fluids in the child", + "entities": [ + "Albumin" + ] + }, + { + "id": "3684", + "type": "gene", + "text": "A combination of comparative sequence analysis and thermodynamic methods reveals the conservation of tertiary structure elements in the 5 ' untranslated region ( UTR ) of human enteroviruses and rhinoviruses .", + "entities": [] + }, + { + "id": "3685", + "type": "gene", + "text": "No difference in the clinical acceptability could be ascertained between the two groups .", + "entities": [] + }, + { + "id": "3686", + "type": "gene", + "text": "Competition analysis by gel mobility shift electrophoresis indicates that this DNA - protein interaction is novel and not related to many transcription factors previously reported .", + "entities": [] + }, + { + "id": "3687", + "type": "gene", + "text": "The RMRI was tested for interrater reliability using three simulated and 10 actual patients .", + "entities": [] + }, + { + "id": "3688", + "type": "gene", + "text": "Replacement of residues in positions + 3 ( His128Asn ) and + 2 ( Gln155Lys ) of the reading helices of fingers 2 and 3 , respectively , prevented binding .", + "entities": [] + }, + { + "id": "3689", + "type": "gene", + "text": "BIAcore analysis gave a Kaff of 4 . 4 x 10 ( 10 ) M - 1 for the binding of N - A3 to T84 . 1 and 2 . 2 x 10 ( 10 ) M - 1 for the binding of N - A3 to T84 . 66 .", + "entities": [ + "N - A3", + "T84 . 1", + "N - A3", + "T84 . 66" + ] + }, + { + "id": "3690", + "type": "gene", + "text": "The emerging complexity of the 5 ' regulatory region of the GH receptor gene was emphasised by the observation that probes derived from exon 1B and the distal 3 ' intron boundary do not hybridise with previously cloned genomic sequences that span the liver - specific P1 promoter and exon 2 .", + "entities": [ + "GH receptor gene" + ] + }, + { + "id": "3691", + "type": "gene", + "text": "OBJECTIVE : To follow - up prospectively patients with arthritis after infection with beta - haemolytic streptococci of Lancefield group A ( beta HSA ) , with emphasis on clinical characteristics and serological features .", + "entities": [] + }, + { + "id": "3692", + "type": "gene", + "text": "Acute pancreatitis : a multisystem disease .", + "entities": [] + }, + { + "id": "3693", + "type": "gene", + "text": "The effect of ethanol on human sensorimotor reactivity was assessed by examining the acoustic startle response .", + "entities": [] + }, + { + "id": "3694", + "type": "gene", + "text": "It was found that the primary visual cortex of the rat is asymmetrical in volume , and that the asymmetry reflects side differences in the number of neurons .", + "entities": [] + }, + { + "id": "3695", + "type": "gene", + "text": "In addition , we also constructed and expressed chimeric fusion protein that contains HIV - 2 gag with V3 domains of HIV - 1IIIB , HIV - 1MN , HIV - 1SF2 and HIV - 1RF .", + "entities": [ + "HIV - 2 gag", + "V3" + ] + }, + { + "id": "3696", + "type": "gene", + "text": "The DHEAS levels in all stages of decreased BMD were significantly lower than those in the group with normal BMD .", + "entities": [] + }, + { + "id": "3697", + "type": "gene", + "text": "Nuclear receptors ( NRs ) can function as ligandinducible transregulators in both mammalian and yeast cells , indicating that important features of transcriptional control have been conserved throughout evolution .", + "entities": [] + }, + { + "id": "3698", + "type": "gene", + "text": "OUTCOME : Acetylcholine receptor antibodies and single - fibre electromyogram were useful in the diagnosis of myasthenia gravis .", + "entities": [ + "Acetylcholine receptor antibodies" + ] + }, + { + "id": "3699", + "type": "gene", + "text": "Binding of U2 small nuclear ribonucleoprotein was partially inhibited .", + "entities": [ + "U2 small nuclear ribonucleoprotein" + ] + }, + { + "id": "3700", + "type": "gene", + "text": "Paradoxically , however , the GH receptor cloned from liver exhibits no sequence similarity to receptors with known signal transduction mechanisms , including those exhibiting ligand - activated tyrosine kinase activity .", + "entities": [ + "GH receptor", + "tyrosine kinase" + ] + }, + { + "id": "3701", + "type": "gene", + "text": "Thiopentone sodium administered at 30 and 10 min before or 5 , 10 and 15 min after exposure to NOC - 5 , but not thereafter , significantly attenuated NO - induced neurotoxicity compared with controls .", + "entities": [] + }, + { + "id": "3702", + "type": "gene", + "text": "Concordance of IBDQ scores was tested in 280 stable subjects .", + "entities": [] + }, + { + "id": "3703", + "type": "gene", + "text": "HER2 overexpressing cells showed a single prominent DNase I hypersensitive site near a conserved and hitherto unrecognized ets response element ( GAGGAA ) , located 38 bases down - stream from the CAAT box and directly 5 ' of the TATA box in the human HER2 promoter .", + "entities": [ + "HER2", + "DNase I", + "ets", + "human HER2 promoter" + ] + }, + { + "id": "3704", + "type": "gene", + "text": "Underlying the clustering of these risk variables were three factors .", + "entities": [] + }, + { + "id": "3705", + "type": "gene", + "text": "Thus , the predicted CD30v protein retains most of the cytoplasmic region , but lacks the extracellular and transmembrane domains .", + "entities": [ + "CD30v protein" + ] + }, + { + "id": "3706", + "type": "gene", + "text": "The 0 . 22 - kb NheI / BglII promoter exhibited PMA inducibility in myeloid cells and contained a PMA - responsive element recognized by Sp1 and EGR - 1 transcription factors .", + "entities": [ + "NheI", + "BglII", + "Sp1", + "EGR - 1 transcription factors" + ] + }, + { + "id": "3707", + "type": "gene", + "text": "Induction of AtP5CS1 mRNA accumulation in salt - treated seedlings involves an immediate early transcriptional response regulated by ABA signalling that is not inhibited by cycloheximide , but abolished by the deficiency of ABA biosynthesis in the aba1 Arabidopsis mutant .", + "entities": [ + "AtP5CS1 mRNA", + "aba1 Arabidopsis mutant" + ] + }, + { + "id": "3708", + "type": "gene", + "text": "The eluent from the column was mixed with the chemiluminescent solution containing lucigenin and Triton X - 100 and a 0 . 28 M KOH solution by pumps and monitored by a chemiluminescence detector .", + "entities": [ + "lucigenin" + ] + }, + { + "id": "3709", + "type": "gene", + "text": "Keratoconjunctivitis sicca appears to be a common ocular complication and all children with JRA should be screened for it with a comprehensive battery of tests .", + "entities": [] + }, + { + "id": "3710", + "type": "gene", + "text": "To determine whether the excess prevalence of human immunodeficiency virus type 1 ( HIV - 1 ) infection in US black and Hispanic homosexual men relative to white men can be explained by differences in sociodemographic factors , history of sexually transmitted diseases , or sexual and drug - use behaviors , the authors conducted a cross - sectional analysis of baseline HIV - 1 seroprevalence and HIV - 1 risk factors among 4 , 475 non - Hispanic white , 234 Hispanic white , and 194 black homosexual men from four centers in the United States ( Baltimore / Washington , DC , Pittsburgh , Chicago , and Los Angeles ) .", + "entities": [] + }, + { + "id": "3711", + "type": "gene", + "text": "The yeast SSS1 gene is essential for secretory protein translocation and encodes a conserved protein of the endoplasmic reticulum .", + "entities": [ + "yeast SSS1 gene" + ] + }, + { + "id": "3712", + "type": "gene", + "text": "Slowly adapting type I mechanoreceptor discharge as a function of dynamic force versus dynamic displacement of glabrous skin of raccoon and squirrel monkey hand .", + "entities": [] + }, + { + "id": "3713", + "type": "gene", + "text": "The main advantages of Multi - MUP analysis are : ( 1 ) quick acquisition of many MUPs ; ( 2 ) simultaneous collection of several MUPs at one recording site ; ( 3 ) possibility to analyze not only low threshold MUPs ; ( 4 ) less bias in the selection of MUPs and ( 5 ) the reproducibility of the results that allow the same reference values to be used in different laboratories .", + "entities": [] + }, + { + "id": "3714", + "type": "gene", + "text": "The median preoperative best - corrected visual acuity of 0 . 08 ( range hand motions / 0 . 003 to 0 . 4 ) , improved by 5 lines to a median final postoperative best - corrected visual acuity of 0 . 25 ( range 0 . 025 - 0 . 5 ) ( P = 0 . 001 ) .", + "entities": [] + }, + { + "id": "3715", + "type": "gene", + "text": "Selection was based on expression of an integrated DNA fragment containing the con - 10 promoter - regulatory region followed by the initial segment of the con - 10 open reading frame fused in frame with the bacterial hygromycin B phosphotransferase structural gene ( con10 ' - ' hph ) .", + "entities": [ + "con - 10 promoter - regulatory region", + "con - 10 open reading frame", + "bacterial hygromycin B phosphotransferase structural gene", + "con10 ' - ' hph" + ] + }, + { + "id": "3716", + "type": "gene", + "text": "Bilateral basal arteries were measured by the transtemporal approach with a 2 MHz pulsed Doppler instrument ( TC - 2 64B EME ) .", + "entities": [] + }, + { + "id": "3717", + "type": "gene", + "text": "A diagnosis of MS was made based on subtle neurologic signs , spinal fluid gamma globulin elevations , and abnormalities in neuropsychological testing .", + "entities": [ + "gamma globulin" + ] + }, + { + "id": "3718", + "type": "gene", + "text": "A prospective trail comparing hysterectomy , hysterectomy plus vaginal radium , and uterine radium plus hysterectomy in stage I endometrial carcinoma .", + "entities": [] + }, + { + "id": "3719", + "type": "gene", + "text": "In order to delineate structural motifs regulating substrate affinity and recognition for the human dopamine transporter ( DAT ) , we assessed [ 3H ] dopamine uptake kinetics and [ 3H ] CFT binding characteristics of COS - 7 cells transiently expressing mutant DATs in which the COOH terminus was truncated or substituted .", + "entities": [ + "human dopamine transporter", + "DAT", + "mutant DATs" + ] + }, + { + "id": "3720", + "type": "gene", + "text": "A recombinant vector , p410 + , was constructed which carried the BamHI - K fragment ( nucleotides 107565 to 112625 of the B95 - 8 strain , encoding the EBV - associated nuclear antigen EBNA - 1 ) , the cis - acting sequence from the BamHI - C fragment , and a dominant selectable marker gene encoding G - 418 resistance in animal cells .", + "entities": [ + "BamHI - K fragment", + "EBNA - 1", + "BamHI - C fragment" + ] + }, + { + "id": "3721", + "type": "gene", + "text": "As well , IFN - gamma - induced expression of IRF - 1 and its binding to the IRF element is inhibited .", + "entities": [ + "IFN - gamma", + "IRF - 1", + "IRF element" + ] + }, + { + "id": "3722", + "type": "gene", + "text": "Range , variations and neoplastic potential .", + "entities": [] + }, + { + "id": "3723", + "type": "gene", + "text": "Studies on powdered preparations .", + "entities": [] + }, + { + "id": "3724", + "type": "gene", + "text": "Two new glucosidase inhibitors ( BAY m 1099 and BAY o 1248 ) were studied in volunteers and type II diabetics under various conditions .", + "entities": [ + "glucosidase" + ] + }, + { + "id": "3725", + "type": "gene", + "text": "cDNA cloning , expression analysis , and chromosomal localization of a gene with high homology to wheat eIF - ( iso ) 4F and mammalian eIF - 4G .", + "entities": [ + "wheat eIF - ( iso ) 4F", + "mammalian eIF - 4G" + ] + }, + { + "id": "3726", + "type": "gene", + "text": "Specifically , by the type of adjuvant therapy , the median disease - free interval and survival from stage IVA for 23 patients receiving Corynebacterium parvum were 6 . 9 and 19 months ; for 39 patients receiving BCG , eight months and 26 months ; for 24 patients receiving BCG + DTIC , eight and 17 . 4 months ; and for all 51 DTIC treated patients 6 . 3 and 17 . 8 months , respectively .", + "entities": [] + }, + { + "id": "3727", + "type": "gene", + "text": "We have screened the elastin gene for mutations responsible for supravalvular aortic stenosis ( SVAS ) in two large , independently collected families with isolated ( nonsyndromic ) SVAS .", + "entities": [ + "elastin gene" + ] + }, + { + "id": "3728", + "type": "gene", + "text": "Native human fibrinogen was brought to coagulation by adding thrombin .", + "entities": [ + "human fibrinogen", + "thrombin" + ] + }, + { + "id": "3729", + "type": "gene", + "text": "Ultrastructure of the tumor in 1 patient in whom transurethral resection was performed 2 weeks after alum irrigation revealed well preserved nuclear chromatin , thus , suggesting that whatever changes occur after alum irrigation are short - lived .", + "entities": [] + }, + { + "id": "3730", + "type": "gene", + "text": "Use of a dual - pulse lithotripter to generate a localized and intensified cavitation field .", + "entities": [] + }, + { + "id": "3731", + "type": "gene", + "text": "The results indicate that DNA methylation , chromatin structure , and transactivation at an Sp1 site contribute to the highly restricted expression of this myelomonocytic lineage specific gene .", + "entities": [ + "Sp1 site" + ] + }, + { + "id": "3732", + "type": "gene", + "text": "A twelfth insertion disrupts two genes , Nrk , a \" neurospecific \" receptor tyrosine kinase , and Tpp , which encodes a neuropeptidase .", + "entities": [ + "Nrk", + "\" neurospecific \" receptor tyrosine kinase", + "Tpp", + "neuropeptidase" + ] + }, + { + "id": "3733", + "type": "gene", + "text": "We tested 10 rats with electrophysiologically guided , ibotenic acid lesions of the PBN ( PBNx ) to determine whether they could acquire a LiCl - induced CTA to l - alanine ( 0 . 3 M ) or demonstrate a sodium appetite following furosemide treatment and overnight access to sodium deficient chow .", + "entities": [] + }, + { + "id": "3734", + "type": "gene", + "text": "However , the published reports consist of a small number of patients and limited data .", + "entities": [] + }, + { + "id": "3735", + "type": "gene", + "text": "Exposure to hepatitis B virus in the general population of Hisayama , Japan : significance of isolated antibody to hepatitis B surface antigen in general population .", + "entities": [ + "hepatitis B surface antigen" + ] + }, + { + "id": "3736", + "type": "gene", + "text": "This motif is similar to but distinct from the LIM domain and the RING finger family , and is reminiscent of known metal - binding regions .", + "entities": [ + "LIM domain", + "RING finger family" + ] + }, + { + "id": "3737", + "type": "gene", + "text": "Transfection and in vitro binding studies identified within HEFT1 a promoter whose basal activity required a GC box activated by Sp1 or Sp3 .", + "entities": [ + "HEFT1 a promoter", + "Sp1", + "Sp3" + ] + }, + { + "id": "3738", + "type": "gene", + "text": "Synovial cysts of the hip joint", + "entities": [] + }, + { + "id": "3739", + "type": "gene", + "text": "A protein footprint also was identified for a GC box element at nucleotides - 59 to - 45 .", + "entities": [] + }, + { + "id": "3740", + "type": "gene", + "text": "ORFA and ccdA were constitutively cotranscribed as determined by primer extension analysis .", + "entities": [ + "ccdA" + ] + }, + { + "id": "3741", + "type": "gene", + "text": "Identification of Ets - and notch - related subunits in GA binding protein .", + "entities": [ + "Ets", + "notch", + "GA binding protein" + ] + }, + { + "id": "3742", + "type": "gene", + "text": "Fourth , the 3 ' - region splice junctions of the MSRs during latent and productive infection were determined by sequencing RNA - PCR products generated with primers that flank the 3 ' splice region .", + "entities": [ + "MSRs" + ] + }, + { + "id": "3743", + "type": "gene", + "text": "Significantly greater improvement ( p < 0 . 05 ) in the sertraline group first became apparent by the end of week 3 on the Y - BOCS and the CGI Improvement scale , and by the end of weeks 6 and 8 , respectively , on the NIMH and CGI Severity scale .", + "entities": [] + }, + { + "id": "3744", + "type": "gene", + "text": "Although within normal limits , latency was high .", + "entities": [] + }, + { + "id": "3745", + "type": "gene", + "text": "Km values for ammonium , 2 - oxoglutarate , NADH , glutamate and NAD + were 6 . 5 , 3 . 5 , 0 . 06 , 37 . 1 and 0 . 046 mM , respectively .", + "entities": [] + }, + { + "id": "3746", + "type": "gene", + "text": "Chronotherapeutics in cardiovascular disease .", + "entities": [] + }, + { + "id": "3747", + "type": "gene", + "text": "In contrast , both Sp1 and ETS proteins are required to bring about full promoter activity in the Surf - 1 direction .", + "entities": [ + "Sp1", + "ETS proteins", + "Surf - 1" + ] + }, + { + "id": "3748", + "type": "gene", + "text": "Translation of the coding segment , which was designated MsPRP2 , suggested it encodes a chimeric 40 , 569 Da cell wall protein with an amino - terminal signal sequence , a repetitive proline - rich sequence , and a cysteine - rich carboxyl - terminal sequence homologous to nonspecific lipid transfer proteins .", + "entities": [ + "MsPRP2" + ] + }, + { + "id": "3749", + "type": "gene", + "text": "In patients resistant to VAD , high - dose therapies with intravenous melphalan , a CBV combination ( cyclophosphamide - BCNU - VP - 16 ) or an EDAP regimen ( VP - 16 - platinum ) produced responses in about 40 % of patients .", + "entities": [] + }, + { + "id": "3750", + "type": "gene", + "text": "These results establish that hydroquinones lead to mutagenicity and carcinogenicity .", + "entities": [] + }, + { + "id": "3751", + "type": "gene", + "text": "Calmodulin - binding peptide ( CBP ) , a peptide of 26 amino acids derived from muscle myosin light chain kinase ( MLCK ) , binds to calmodulin with nanomolar affinity .", + "entities": [ + "Calmodulin - binding peptide", + "CBP", + "muscle myosin light chain kinase", + "MLCK", + "calmodulin" + ] + }, + { + "id": "3752", + "type": "gene", + "text": "The full protocol was completed by 33 patients ( 45 % of original cohort ) .", + "entities": [] + }, + { + "id": "3753", + "type": "gene", + "text": "The effect of site - specific mutations in the mouse platelet - derived growth factor ( PDGF ) beta - receptor on activation of the Na + / H + exchanger was examined in normal murine mammary gland epithelial ( NMuMG ) and Chinese hamster ovary ( CHO ) cells .", + "entities": [ + "mouse platelet - derived growth factor ( PDGF ) beta - receptor", + "Na + / H + exchanger" + ] + }, + { + "id": "3754", + "type": "gene", + "text": "In AcMNPV - infected Sf9 cells , late transcription initiation is detected from only two upstream TAAG sites and not from three downstream TAAG sites .", + "entities": [] + }, + { + "id": "3755", + "type": "gene", + "text": "Radiogallium imaging is thus of limited use in evaluation of suspected giant cell tumors of bone .", + "entities": [] + }, + { + "id": "3756", + "type": "gene", + "text": "ACTH release is transiently suppressed in some children after exogenous ACTH treatment .", + "entities": [ + "ACTH", + "ACTH" + ] + }, + { + "id": "3757", + "type": "gene", + "text": "Finally , a chromogenic method was used , based on thrombin inhibition and the substrate S - 2238 .", + "entities": [ + "thrombin" + ] + }, + { + "id": "3758", + "type": "gene", + "text": "Cardiovascular risk factors and antihypertensive treatment .", + "entities": [] + }, + { + "id": "3759", + "type": "gene", + "text": "These results indicate that BACM has antiplaque and stronger antidegradation effects than GLCM .", + "entities": [] + }, + { + "id": "3760", + "type": "gene", + "text": "DNase I footprinting of the proximal promoter revealed four regions of protection .", + "entities": [ + "DNase I" + ] + }, + { + "id": "3761", + "type": "gene", + "text": "Thus , quantitative analysis of thallium - 201 uptake and washout provided objective evidence for improved myocardial perfusion after coronary angioplasty .", + "entities": [] + }, + { + "id": "3762", + "type": "gene", + "text": "Severe hemolysis resulted in statistically significant changes in the mean values of the above analytes in addition to the following increases : alanine aminotransferase , calcium , and serum globulins ( P < 0 . 001 ) and albumin and total protein ( P < 0 . 01 ) .", + "entities": [ + "alanine aminotransferase", + "serum globulins", + "albumin" + ] + }, + { + "id": "3763", + "type": "gene", + "text": "Theories proffered to account for the modality shift effect are critically evaluated .", + "entities": [] + }, + { + "id": "3764", + "type": "gene", + "text": "Infect .", + "entities": [] + }, + { + "id": "3765", + "type": "gene", + "text": "TB bone area ( p < 0 . 001 ) , height ( p < 0 . 01 ) , years in present colony ( p = 0 . 03 ) , and menses ( p < 0 . 01 ) predicted TB BMC .", + "entities": [] + }, + { + "id": "3766", + "type": "gene", + "text": "Current status of telepathology .", + "entities": [] + }, + { + "id": "3767", + "type": "gene", + "text": "Although noninhibitory fluid had higher mean concentrations of phosphorus and zinc , these differences did not hold after meconium - stained samples were excluded .", + "entities": [] + }, + { + "id": "3768", + "type": "gene", + "text": "The second group of homologous elements is present in the upstream region of both genes .", + "entities": [] + }, + { + "id": "3769", + "type": "gene", + "text": "Thus , blocks in the RARalpha - specific pathway of retinoid - induced differentiation may be bypassed during retinoid induction of FR - beta expression .", + "entities": [ + "RARalpha", + "FR - beta" + ] + }, + { + "id": "3770", + "type": "gene", + "text": "While the latter corresponded to a protein of 824 amino acids , an upstream open reading frame ( uORF ) within the 5 ' leader could potentially encode a 54 amino acid peptide .", + "entities": [] + }, + { + "id": "3771", + "type": "gene", + "text": "A 38 - year - old woman with ulcerative colitis subsequently developed sarcoidosis .", + "entities": [] + }, + { + "id": "3772", + "type": "gene", + "text": "Diltiazem caused significant decrease in the ventricular response without conversion to sinus rhythm .", + "entities": [] + }, + { + "id": "3773", + "type": "gene", + "text": "Several features of 10 . 24 . 6 cells suggest that the mutation disrupts normal intracellular formation of peptide / DR complexes .", + "entities": [ + "peptide / DR complexes" + ] + }, + { + "id": "3774", + "type": "gene", + "text": "cDNA clones encoding Arabidopsis thaliana and Zea mays mitochondrial chaperonin HSP60 and gene expression during seed germination and heat shock .", + "entities": [ + "HSP60" + ] + }, + { + "id": "3775", + "type": "gene", + "text": "Competitionsupershift EMSA assays revealed that multiple proteins were involved in bandshift complex formation with KCS , one of which was identified as factor Sp1 .", + "entities": [ + "KCS" + ] + }, + { + "id": "3776", + "type": "gene", + "text": "In this report , we identify and characterize two overlapping ELL functional domains that govern its interaction with RNA polymerase II and the ternary elongation complex .", + "entities": [ + "ELL functional domains", + "RNA polymerase II" + ] + }, + { + "id": "3777", + "type": "gene", + "text": "In patients who were not vented , there was overall significant depression of function ( 67 + / - 5 % of control ; range , 91 - - 45 % , p less than 0 . 01 ) .", + "entities": [] + }, + { + "id": "3778", + "type": "gene", + "text": "Sequencing analysis revealed that the 0 . 54 - and 0 . 4 - kb fragments are identical except for 150 nucleotides missing at the 5 ' region of the 0 . 4 - kb fragment .", + "entities": [] + }, + { + "id": "3779", + "type": "gene", + "text": "Furthermore , hormonal regulation of G ( 1 ) gene transcription can occur even without additional activation of the Mek - Erk1 / 2 pathway by estrogen receptors .", + "entities": [ + "Mek", + "Erk1 / 2", + "estrogen receptors" + ] + }, + { + "id": "3780", + "type": "gene", + "text": "The end - stage or involutional phase of proliferative diabetic retinopathy may result in stabilization of vision for long periods of time .", + "entities": [] + }, + { + "id": "3781", + "type": "gene", + "text": "Cerebro - oculo - facioskeletal syndrome ( Pena - Shokeir syndrome II )", + "entities": [] + }, + { + "id": "3782", + "type": "gene", + "text": "Psychological examinations in patients with chronic kidney insufficiency", + "entities": [] + }, + { + "id": "3783", + "type": "gene", + "text": "VP5 , which encodes the major capsid protein , each fused to the chloramphenicol acetyltransferase gene .", + "entities": [ + "VP5", + "major capsid protein", + "chloramphenicol acetyltransferase gene" + ] + }, + { + "id": "3784", + "type": "gene", + "text": "For the study of the transition of long to short waves ( deep - water waves ) a closed - form solution is advantageous ; this can , however , only be obtained at the cost of further simplification .", + "entities": [] + }, + { + "id": "3785", + "type": "gene", + "text": "The association of p255 with splicing complexes is suggested by the finding that mAb CC3 can inhibit in vitro splicing and immunoprecipitate pre - messenger RNA and splicing products .", + "entities": [ + "p255", + "mAb CC3" + ] + }, + { + "id": "3786", + "type": "gene", + "text": "To our knowledge , type IV renal tubular acidosis has not been reported previously in association with Alport ' s syndrome in an adult patient .", + "entities": [] + }, + { + "id": "3787", + "type": "gene", + "text": "Expression and characterization of recombinant single - chain Fv and Fv fragments derived from a set of catalytic antibodies .", + "entities": [ + "recombinant single - chain Fv", + "Fv fragments" + ] + }, + { + "id": "3788", + "type": "gene", + "text": "Retinoids participate in the onset of differentiation , apoptosis and the inhibition of growth in a wide variety of normal and cancerous cells .", + "entities": [] + }, + { + "id": "3789", + "type": "gene", + "text": "Furthermore , experiments with 32D temperature - sensitive p53 cells indicate that aberrant tal - 1 expression at the permissive temperature does not exert a proliferative effect but causes p53 - mediated apoptosis , i . e . , the tal - 1 proliferative effect depends on the integrity of the cell cycle checkpoints of the host cell , as observed for c - myc and other oncogenes .", + "entities": [ + "p53", + "tal - 1", + "p53", + "tal - 1", + "c - myc" + ] + }, + { + "id": "3790", + "type": "gene", + "text": "tal - 1 mutant experiments indicate that ectopic tal - 1 effects are mediated by both the DNA - binding and the heterodimerization domains , while the N - terminally truncated tal - 1 variant ( M3 ) expressed in T - ALL malignant cells mimics the effects of the wild - type protein .", + "entities": [ + "tal - 1 mutant", + "tal - 1", + "N - terminally truncated tal - 1 variant", + "M3" + ] + }, + { + "id": "3791", + "type": "gene", + "text": "Mobilization with cyclophosphamide and granulocyte - colony stimulating factor was effective in terms of CD34 + cell shift to peripheral blood and the good quality autograft reliably led to haematopoetic recovery after megachemotherapy .", + "entities": [ + "granulocyte - colony stimulating factor", + "CD34 +" + ] + }, + { + "id": "3792", + "type": "gene", + "text": "Experimental reproduction of malignant catarrhal fever in Bali cattle", + "entities": [] + }, + { + "id": "3793", + "type": "gene", + "text": "The corn and mineral oil emulsions were almost as effective as milk but less effective than sucrose ( 0 . 3M ) in stimulating ingestion .", + "entities": [] + }, + { + "id": "3794", + "type": "gene", + "text": "The results show that nerve and roots differ considerably both in the force they sustain before failure and in the other biomechanics they exhibit .", + "entities": [] + }, + { + "id": "3795", + "type": "gene", + "text": "In addition , the regulation of Glvr - 1 gene expression also has potential applications to gene therapy , since retroviral vectors carrying gibbon ape leukemia virus envelope proteins are used for gene delivery into different cell types .", + "entities": [ + "Glvr - 1 gene", + "gibbon ape leukemia virus envelope proteins" + ] + }, + { + "id": "3796", + "type": "gene", + "text": "Temperature measurement in microfluidic systems using a temperature - dependent fluorescent dye .", + "entities": [] + }, + { + "id": "3797", + "type": "gene", + "text": "Nucleotide sequence , transcription map , and mutation analysis of the 13q14 chromosomal region deleted in B - cell chronic lymphocytic leukemia .", + "entities": [] + }, + { + "id": "3798", + "type": "gene", + "text": "Male - enhanced antigen gene is phylogenetically conserved and expressed at late stages of spermatogenesis .", + "entities": [ + "Male - enhanced antigen gene" + ] + }, + { + "id": "3799", + "type": "gene", + "text": "The incidence of DNCB reactions was 78 per cent for Stage I and II cancers ( 37 patinets ) , 73 per cent for resectable Stage III cancer ( 22 patients ) , and 66 per cent in patients with unresectable or inoperable Stage III cancer .", + "entities": [] + }, + { + "id": "3800", + "type": "gene", + "text": "The decrements in cerebrovascular resistance induced by hexamethonium , in mm Hg ml ( - 1 ) . min ( - 1 ) , were : under control .", + "entities": [] + }, + { + "id": "3801", + "type": "gene", + "text": "Treatment of human myeloid cell lines HL - 60 and U937 with phorbol 12 - myristate 13 - acetate ( PMA ) increased within 2 h cellular levels of the RNA hybridizable to LD78 cDNA .", + "entities": [ + "LD78 cDNA" + ] + }, + { + "id": "3802", + "type": "gene", + "text": "After 6 months , definite improvement in strength occurred in 4 of 7 carnitine - treated patients and in none of 7 controls .", + "entities": [] + }, + { + "id": "3803", + "type": "gene", + "text": "Responsibility matters - - this is a scientific council", + "entities": [] + }, + { + "id": "3804", + "type": "gene", + "text": "We have utilized the human 4F2 heavy chain ( 4F2HC ) gene as a model system in studies designed to elucidate the molecular events involved in regulating inducible gene expression during normal human T - cell activation .", + "entities": [ + "human 4F2 heavy chain", + "4F2HC" + ] + }, + { + "id": "3805", + "type": "gene", + "text": "Isolation of a near full - length cDNA from a human fetal brain cDNA library revealed a protein serine - threonine phosphatase with a tetratricopeptide motif , almost identical to human PPP5C ( PP5 ) and highly homologous to rat PPT .", + "entities": [ + "protein serine - threonine phosphatase", + "human PPP5C", + "PP5", + "rat PPT" + ] + }, + { + "id": "3806", + "type": "gene", + "text": "CONCLUSION : SPT is more useful than WST in differentiating patients predisposed to aspiration .", + "entities": [] + }, + { + "id": "3807", + "type": "gene", + "text": "In vitro transcription extracts from ret1 - 1 cells terminate less efficiently at weak transcription termination signals than those from RET1 cells , using a variety of tRNA templates .", + "entities": [ + "ret1 - 1", + "RET1" + ] + }, + { + "id": "3808", + "type": "gene", + "text": "In order to better characterize the distribution of ML and MAP estimates under these conditions , we derive a point approximation to density values of the conditional distribution of such estimates .", + "entities": [] + }, + { + "id": "3809", + "type": "gene", + "text": "MAIN OUTCOME MEASURE : A positive test result for gonococcal or chlamydial infection by the ligase chain reaction assay ; secondary outcome measure was a positive test result for human immunodeficiency virus ( HIV ) .", + "entities": [ + "ligase" + ] + }, + { + "id": "3810", + "type": "gene", + "text": "Phylogenetic position of the Phacotaceae within the Chlamydophyceaeas revealed by analysis of 18S rDNA and rbcL sequences .", + "entities": [ + "18S rDNA", + "rbcL sequences" + ] + }, + { + "id": "3811", + "type": "gene", + "text": "Stress - activated protein kinase 1 ( SAPK1 ) , also called c - Jun N - terminal kinase ( JNK ) , becomes activated in vivo in response to pro - inflammatory cytokines or cellular stresses .", + "entities": [ + "Stress - activated protein kinase 1", + "SAPK1", + "c - Jun N - terminal kinase", + "JNK" + ] + }, + { + "id": "3812", + "type": "gene", + "text": "Gene constructs consisting of human growth hormone ( hGH ) gene driven by promoter / regulatory sequence of mouse metallothionein ( mMT ) , viral thymidine kinase ( vTK ) , rat cholecystokinin ( rCCK ) , or chicken beta - actin ( cBA ) gene were injected into the cytoplasm of fertilized medaka eggs via the micropyle .", + "entities": [ + "human growth hormone", + "hGH", + "mouse metallothionein", + "mMT", + "viral thymidine kinase", + "vTK", + "rat cholecystokinin", + "rCCK", + "chicken beta - actin", + "cBA" + ] + }, + { + "id": "3813", + "type": "gene", + "text": "Transient tyrosine phosphorylation of Crk in fibroblast growth factor - 2 - stimulated endothelial cells was dependent on the juxtamembrane tyrosine residue 463 in FGFR - 1 , and a Crk SH2 domain precipitated FGFR - 1 via phosphorylated Tyr - 463 , indicating direct complex formation between Crk and FGFR - 1 .", + "entities": [ + "Crk", + "fibroblast growth factor - 2", + "FGFR - 1", + "SH2 domain", + "FGFR - 1", + "Crk", + "FGFR - 1" + ] + }, + { + "id": "3814", + "type": "gene", + "text": "The perioperative mortality of all patients was 1 . 9 % , the mortality of patients older than 70 years was 4 . 3 % .", + "entities": [] + }, + { + "id": "3815", + "type": "gene", + "text": "Based on 213 determinations , the control mean serum CPK activity was 262 + / - 113 I . U . / liter .", + "entities": [ + "serum CPK" + ] + }, + { + "id": "3816", + "type": "gene", + "text": "Interestingly , the similarities with the endophilin proteins cover the entire sequence of the SH3GLB family , suggesting a common fold and presumably a common mode of action .", + "entities": [ + "endophilin proteins", + "SH3GLB family" + ] + }, + { + "id": "3817", + "type": "gene", + "text": "The plateau MO2 value was that predicted by allometric relation .", + "entities": [] + }, + { + "id": "3818", + "type": "gene", + "text": "The marker orders from the genetic and RH maps were consistent .", + "entities": [] + }, + { + "id": "3819", + "type": "gene", + "text": "Additionally , I kappa B beta , but not I kappa B alpha , also prevented the binding of Rel to the kappa B site .", + "entities": [ + "I kappa B beta", + "I kappa B alpha", + "Rel", + "kappa B site" + ] + }, + { + "id": "3820", + "type": "gene", + "text": "The phosphotransferase system ( PTS ) of Streptomyces coelicolor identification and biochemical analysis of a histidine phosphocarrier protein HPr encoded by the gene ptsH .", + "entities": [ + "HPr", + "ptsH" + ] + }, + { + "id": "3821", + "type": "gene", + "text": "Thus , the class C - Vps complex directs multiple reactions during the docking and fusion of vesicles with the vacuole , each of which contributes to the overall specificity and efficiency of this transport process .", + "entities": [ + "class C", + "Vps" + ] + }, + { + "id": "3822", + "type": "gene", + "text": "Rainbow trout were obtained from a commercial trout farm , kept in running water and feeding in experimental pellets for 4 to 8 weeks .", + "entities": [] + }, + { + "id": "3823", + "type": "gene", + "text": "The rate of decrement in DPOAE amplitude over a prescribed time period was utilized as a measure of susceptibility to the acoustic trauma .", + "entities": [] + }, + { + "id": "3824", + "type": "gene", + "text": "Most of the expressed human E3 polypeptides ( five bands ) were found in the insoluble pellet while primarily full - length mature E3 was found in the soluble fraction .", + "entities": [ + "human E3 polypeptides", + "full - length mature E3" + ] + }, + { + "id": "3825", + "type": "gene", + "text": "Molecular cloning of mouse thioredoxin reductases .", + "entities": [ + "mouse thioredoxin reductases" + ] + }, + { + "id": "3826", + "type": "gene", + "text": "The maximal effect was seen at 100 ng / ml EGF , with a time lag of about 5 h .", + "entities": [ + "EGF" + ] + }, + { + "id": "3827", + "type": "gene", + "text": "Cdc2 co - precipitates with Pch1 in S . pombe cell lysates , although Cdc2 may not be the major catalytic partner of a Pch1 kinase in vivo .", + "entities": [ + "Cdc2", + "Pch1", + "Cdc2", + "Pch1 kinase" + ] + }, + { + "id": "3828", + "type": "gene", + "text": "Sodium - taurocholate - induced acute necrotizing pancreatitis does not affect jejunal oxygenation in pigs .", + "entities": [] + }, + { + "id": "3829", + "type": "gene", + "text": "Production of C mu RNAs , unlike mu mRNAs , does not require recombination with the joining region ( JH ) locus .", + "entities": [ + "C mu RNAs", + "mu mRNAs", + "joining region", + "JH" + ] + }, + { + "id": "3830", + "type": "gene", + "text": "In addition , the time to engraftment was significantly shorter in the amifostine arm in both cohorts .", + "entities": [] + }, + { + "id": "3831", + "type": "gene", + "text": "It has also been shown that a variety of extracellular factors stimulate a pair of MAPK p44 and MAPK p42 of MAPK family members .", + "entities": [ + "p44", + "p42", + "MAPK family members" + ] + }, + { + "id": "3832", + "type": "gene", + "text": "Consistent with the in vivo result , the pseudorevertant endonucleases in the crude cell extract display site - specific partial DNA cleavage activity .", + "entities": [] + }, + { + "id": "3833", + "type": "gene", + "text": "Azithromycin is a new generation macrolide antibiotic with unusual and favorable pharmacokinetics , and seems to be a very promising agent for innovative anti - H . pylori regimens .", + "entities": [] + }, + { + "id": "3834", + "type": "gene", + "text": "The progression of acute bronchitis is associated with elevated blood concentrations of acute - phase proteins , KKS activation in the blood and high serotonin and lactic acid content in the humor condensated from the exhaled air .", + "entities": [ + "KKS" + ] + }, + { + "id": "3835", + "type": "gene", + "text": "For higher expression of lipA in S . lividans , the gene was cloned next to the strong aphII promoter .", + "entities": [ + "lipA", + "aphII promoter" + ] + }, + { + "id": "3836", + "type": "gene", + "text": "These results suggest that decreased class I enhancer activity in Ad12 - transformed cells may , at least in part , be due to the higher levels of an enhancer - specific factor , possibly acting as a repressor .", + "entities": [] + }, + { + "id": "3837", + "type": "gene", + "text": "Differential screening of mitochondrial cDNA libraries from male - fertile and cytoplasmic male - sterile sugar - beet reveals genome rearrangements at atp6 and atpA loci .", + "entities": [ + "atp6", + "atpA loci" + ] + }, + { + "id": "3838", + "type": "gene", + "text": "The results demonstrate ( i ) that the selenocysteine - specific UGA codon is readily suppressed under conditions where the homologous SelB protein is absent and ( ii ) that apart from the specificity of the SelB - mRNA interaction , a structural compatibility of the quaternary complex with the ribosome is required .", + "entities": [ + "homologous SelB protein", + "SelB - mRNA" + ] + }, + { + "id": "3839", + "type": "gene", + "text": "Rapid evolution of the DNA - binding site in LAGLIDADG homing endonucleases .", + "entities": [ + "LAGLIDADG homing endonucleases" + ] + }, + { + "id": "3840", + "type": "gene", + "text": "Adverse foetal outcome in specific IgM positive Chlamydia trachomatis infection in pregnancy .", + "entities": [ + "IgM" + ] + }, + { + "id": "3841", + "type": "gene", + "text": "This negative regulatory pathway may be important for determining cell fate or maintaining an inducible state in the ventroposterior region of the embryo .", + "entities": [] + }, + { + "id": "3842", + "type": "gene", + "text": "Here we show that for expression of snRNA genes in maize , a monocotyledonous plant , the USE and TATA elements are essential , but not sufficient , for transcription .", + "entities": [] + }, + { + "id": "3843", + "type": "gene", + "text": "The hematopoietic colony - stimulating factors ( CSF ) have been introduced into clinical practice as additional supportive measures that can reduce the incidence of infectious complications in patients with cancer and neutropenia .", + "entities": [ + "hematopoietic colony - stimulating factors", + "CSF" + ] + }, + { + "id": "3844", + "type": "gene", + "text": "ATP - dependent assembly of a ternary complex consisting of a DNA mismatch and the yeast MSH2 - MSH6 and MLH1 - PMS1 protein complexes .", + "entities": [ + "MSH2", + "MSH6", + "MLH1", + "PMS1" + ] + }, + { + "id": "3845", + "type": "gene", + "text": "Surprisingly , the Xenopus U7 gene contains two adjacent octamer - binding motifs located only 12 and 24 bp upstream from the PSE , instead of the usual location around 150 - 200 bp upstream .", + "entities": [ + "Xenopus U7 gene", + "PSE" + ] + }, + { + "id": "3846", + "type": "gene", + "text": "Mean Hg concentrations in the livers of mice at some sites in Isle Royale are not significantly lower ( P = 0 . 62 ) than Hg concentrations considered by some government agencies to be unhealthy for human consumption .", + "entities": [] + }, + { + "id": "3847", + "type": "gene", + "text": "Not even extensive pancreatic resection could prevent pancreatic remnant infection .", + "entities": [] + }, + { + "id": "3848", + "type": "gene", + "text": "The structural changes in intra - acinar artery manifested mainly by an increase in number of muscular artery resulting from muscularization of precursor cells ( pericytes and intermediate cells ) located within partially muscular and nonmuscular arterial wall to smooth muscle cell , and by the medial wall thickened due to hypertrophy and hyperplasia of smooth muscle cells as well as accumulation of a large amount of collagen , especially the type 1 collagen .", + "entities": [ + "collagen", + "type 1 collagen" + ] + }, + { + "id": "3849", + "type": "gene", + "text": "In addition , TRP1 RI Circle DNA is organized into nucleosomes whose size and spacing are indistinguishable from that of bulk yeast chromatin .", + "entities": [ + "TRP1" + ] + }, + { + "id": "3850", + "type": "gene", + "text": "We took advantage of the high degree of aa sequence homology between DAHPSs from several species to isolate ARO3 homologues from the pathogenic yeast Candida albicans .", + "entities": [ + "DAHPSs", + "ARO3 homologues" + ] + }, + { + "id": "3851", + "type": "gene", + "text": "100 of the patients who would have died survive .", + "entities": [] + }, + { + "id": "3852", + "type": "gene", + "text": "In agreement with previous in vitro data , we have shown that UmuD and UmuD ' are able to form both homodimers ( UmuD - UmuD and UmuD ' - UmuD ' ) and a heterodimer ( UmuD - UmuD ' ) .", + "entities": [ + "UmuD", + "UmuD '", + "UmuD", + "UmuD", + "UmuD '", + "UmuD '", + "UmuD", + "UmuD '" + ] + }, + { + "id": "3853", + "type": "gene", + "text": "The human pathogenic bacterium group A Streptococcus produces an extracellular cysteine protease [ streptococcal pyrogenic exotoxin B ( SpeB ) ] that is a critical virulence factor for invasive disease episodes .", + "entities": [ + "cysteine protease", + "streptococcal pyrogenic exotoxin B", + "SpeB" + ] + }, + { + "id": "3854", + "type": "gene", + "text": "According to the laboratory results , the application of neural network can solve the problem successfully .", + "entities": [] + }, + { + "id": "3855", + "type": "gene", + "text": "Comparison of patients receiving phenytoin and those who were not showed significantly lower serum folate in the sub - group receiving phenytoin , but there was no significant difference between the sub - groups with respect to vitamin B12 or behaviour problem rating .", + "entities": [] + }, + { + "id": "3856", + "type": "gene", + "text": "In contrast , we observed high concentrations in 29 of 75 patients with tumors of the central nervous system , especially in meningioma ( 6 / 9 ) , glioblastoma ( 9 / 23 ) , and neurinoma ( 5 / 5 ) .", + "entities": [] + }, + { + "id": "3857", + "type": "gene", + "text": "Endostatin treatment for 10 minutes or 24 hours induced tyrosine phosphorylation of Shb and formation of multiprotein complexes .", + "entities": [ + "Shb" + ] + }, + { + "id": "3858", + "type": "gene", + "text": "Surgical treatment of pathologic scars of myocardial infarct", + "entities": [] + }, + { + "id": "3859", + "type": "gene", + "text": "Familial juvenile nephronophthisis", + "entities": [] + }, + { + "id": "3860", + "type": "gene", + "text": "Mutation of Enh4 , an essential GT - IIC - like enhanson in the context of the intact enhancer , abolishes silencer activity , and multimerized GT - IIC enhansons mimic the intact CSEn enhancer / silencer activities in BeWo and GC cells , respectively .", + "entities": [ + "Enh4", + "GT - IIC - like enhanson", + "GT - IIC enhansons", + "CSEn enhancer / silencer" + ] + }, + { + "id": "3861", + "type": "gene", + "text": "Stable transfection of human CHOP cDNA into mammary carcinoma cells demonstrated that CHOP functioned not as a mediator of hGH - stimulated mitogenesis but rather enhanced the protection from apoptosis afforded by hGH in a p38 MAPK - dependent manner .", + "entities": [ + "human CHOP cDNA", + "CHOP", + "hGH", + "hGH", + "p38" + ] + }, + { + "id": "3862", + "type": "gene", + "text": "We previously demonstrated that acute expression of the bovine papillomavirus type 1 ( BPV1 ) E2 protein in HeLa and HT - 3 cervical carcinoma cell lines greatly reduced cellular proliferation by imposing a specific G1 / S phase growth arrest .", + "entities": [ + "E2 protein" + ] + }, + { + "id": "3863", + "type": "gene", + "text": "The penicillin binding proteins ( PBPs ) synthesize and remodel peptidoglycan , the structural component of the bacterial cell wall .", + "entities": [ + "penicillin binding proteins", + "PBPs" + ] + }, + { + "id": "3864", + "type": "gene", + "text": "A degenerate DNA transposon , Pat , was identified in the genomes of various wild - type strains of the filamentous fungus Podospora anserina .", + "entities": [ + "Pat" + ] + }, + { + "id": "3865", + "type": "gene", + "text": "Both normal and transforming PCPH proteins have guanosine diphosphatase activity but only the oncoprotein cooperates with Ras in activating extracellular signal - regulated kinase ERK1 .", + "entities": [ + "PCPH proteins", + "guanosine diphosphatase", + "Ras", + "ERK1" + ] + }, + { + "id": "3866", + "type": "gene", + "text": "On the basis of S1 nuclease protection analysis of RNA preparations from several mouse tissues , both dhfr and divergent genes showed similar levels of expression but did show some specificity in start site utilization .", + "entities": [ + "S1 nuclease", + "dhfr" + ] + }, + { + "id": "3867", + "type": "gene", + "text": "The US National Institute on Alcohol Abuse and Alcoholism ( NIAAA ) recognizes two forms of problematic drinking : ' willful alcohol abuse ' , a behavioural problem , and ' alcohol dependence ' , a true medical disorder , which includes a genetic component , that can be scientifically understood and medically treated .", + "entities": [] + }, + { + "id": "3868", + "type": "gene", + "text": "Scalp flaps can be expanded just to the point of becoming noticeable over 4 to 6 weeks followed by scalp flap transposition and easy closure of the donor site .", + "entities": [] + }, + { + "id": "3869", + "type": "gene", + "text": "HEF1 , p130 ( Cas ) , and Efs / Sin constitute a family of multidomain docking proteins that have been implicated in coordinating the regulation of cell adhesion .", + "entities": [ + "HEF1", + "p130", + "Cas", + "Efs", + "Sin" + ] + }, + { + "id": "3870", + "type": "gene", + "text": "( 1998 ) J .", + "entities": [] + }, + { + "id": "3871", + "type": "gene", + "text": "These findings suggest that there may be a relationship between the pathogenesis of MAL , narcolepsy , and OSA .", + "entities": [] + }, + { + "id": "3872", + "type": "gene", + "text": "The efficacy of a Propionibacterium acnes product for treatment of coliform mastitis was evaluated following intramammary infusion of Escherichia coli .", + "entities": [] + }, + { + "id": "3873", + "type": "gene", + "text": "Axillary nodal status , tumour progesterone receptor status , and season of tumour detection significantly influenced survival in both older ( greater than 50 yrs ) and younger ( less than 50 yrs ) patients .", + "entities": [ + "progesterone receptor" + ] + }, + { + "id": "3874", + "type": "gene", + "text": "Although the terminase apparently interacts with this gp20 portal peptide , polyclonal antibody against the portal peptide appears unable to access it in the native structure , suggesting intimate association of gp20 and gp17 possibly internalizes terminase regions within the portal in the packasome complex .", + "entities": [ + "terminase", + "gp20 portal peptide", + "gp20", + "gp17", + "terminase regions" + ] + }, + { + "id": "3875", + "type": "gene", + "text": "Intestinal adaptation ( first of two parts ) .", + "entities": [] + }, + { + "id": "3876", + "type": "gene", + "text": "The initial patients treated with AZQ and mitroxantrone experienced prolonged bone marrow suppression and , therefore , subsequent cohorts were treated with G - CSF , 5 micrograms / kg , beginning the day after completion of the third cycle of chemotherapy .", + "entities": [ + "G - CSF" + ] + }, + { + "id": "3877", + "type": "gene", + "text": "We now show that gp200 - MR6 ligation can also mimic IL - 4 and have an anti - proliferative pro - maturational influence within the immune system , causing up - regulation of co - stimulatory molecules on B lymphocytes .", + "entities": [ + "gp200", + "MR6", + "IL - 4" + ] + }, + { + "id": "3878", + "type": "gene", + "text": "CDDP is active as a single agent in non - Hodgkin ' s lymphoma .", + "entities": [] + }, + { + "id": "3879", + "type": "gene", + "text": "Evaluation of the new Gravigard IUCD inserter .", + "entities": [] + }, + { + "id": "3880", + "type": "gene", + "text": "A 3 - yr retrospective review is effective and detects 94 % of the undercalls .", + "entities": [] + }, + { + "id": "3881", + "type": "gene", + "text": "The spectrum of phenotypes caused by these mutations was strikingly different than mutations in the adaptor for the VP16 activation domain .", + "entities": [ + "VP16 activation domain" + ] + }, + { + "id": "3882", + "type": "gene", + "text": "The proliferation potential protein - related ( P2P - R ) gene with domains encoding heterogeneous nuclear ribonucleoprotein association and Rb1 binding shows repressed expression during terminal differentiation .", + "entities": [ + "proliferation potential protein - related", + "P2P - R", + "Rb1" + ] + }, + { + "id": "3883", + "type": "gene", + "text": "We report here that constitutively active Mek1 could activate p96h2bk in the absence of oncogenic Ras .", + "entities": [ + "Mek1", + "p96h2bk", + "oncogenic Ras" + ] + }, + { + "id": "3884", + "type": "gene", + "text": "The molecular mechanism of Tax - mediated trans - activation has been well investigated .", + "entities": [ + "Tax" + ] + }, + { + "id": "3885", + "type": "gene", + "text": "Embryo coculture system may contribute to understand the mechanisms underlying the decrease of fertility with aging .", + "entities": [] + }, + { + "id": "3886", + "type": "gene", + "text": "Eleven healthy , normotensive males undergoing routine restorative dental care were evaluated during treatment for possible hemodynamic alterations in response to potential sympathetic nervous system stimulation .", + "entities": [] + }, + { + "id": "3887", + "type": "gene", + "text": "Quantitative analysis of DNA using flow cytometry and immunocytochemical findings in 16 cases of cardiac myxomas", + "entities": [] + }, + { + "id": "3888", + "type": "gene", + "text": "Human bcl3 protein specifically displaces ( p50 ) 2 - DNA complexes .", + "entities": [ + "Human bcl3 protein", + "( p50 ) 2 - DNA complexes" + ] + }, + { + "id": "3889", + "type": "gene", + "text": "Anti - B . burgdorferi , anti - B . turicatae and anti - B . parkeri antibodies , tested by the indirect immunofluorescent assay ( IFA ) , were detected in 10 . 8 , 16 . 1 and 8 . 2 % of the serum samples tested , and confirmed by IFA - ABS in 1 . 3 , 1 . 3 and 1 . 0 % , respectively .", + "entities": [ + "Anti - B . burgdorferi", + "anti - B . turicatae", + "anti - B . parkeri antibodies" + ] + }, + { + "id": "3890", + "type": "gene", + "text": "Of the 153 patients studied , CK - MB results were positive in 91 ( 59 % ) patients ; ECG revealed AMI in 72 ( 47 % ) patients .", + "entities": [ + "CK - MB" + ] + }, + { + "id": "3891", + "type": "gene", + "text": "Homodimers of the three proteins specifically recognize the G - box motif , with GBF1 and GBF3 binding symmetrically to this palindromic sequence .", + "entities": [ + "GBF1", + "GBF3" + ] + }, + { + "id": "3892", + "type": "gene", + "text": "METHODS : We studied the clinical benefit of depth - dependent RR , nonuniform AC using a scanning line source , and scatter correction ( photon energy recovery [ PER ] ) compared with filtered backprojection alone .", + "entities": [] + }, + { + "id": "3893", + "type": "gene", + "text": "A cluster of basic amino acids , KKKR , generated by joining of the sequences encoded by the constitutive exon 13 and the alternative exon 16 , is necessary for the nuclear targeting of 4 . 1H , as demonstrated by site - directed mutagenesis analysis .", + "entities": [ + "4 . 1H" + ] + }, + { + "id": "3894", + "type": "gene", + "text": "Repair of a cosmetic defect of the lower leg with a myocutaneous free flap .", + "entities": [] + }, + { + "id": "3895", + "type": "gene", + "text": "The 5 ' region of ADH5 contains consensus binding sites for the transcriptional regulatory proteins , Sp1 , AP2 , LF - A1 , NF - 1 , NF - A2 , and NF - E1 .", + "entities": [ + "ADH5", + "Sp1", + "AP2", + "LF - A1", + "NF - 1", + "NF - A2", + "NF - E1" + ] + }, + { + "id": "3896", + "type": "gene", + "text": "This study describes a new MADS box gene , nmhC5 , which along with nmh7 ( J .", + "entities": [ + "MADS box gene", + "nmhC5", + "nmh7" + ] + }, + { + "id": "3897", + "type": "gene", + "text": "One of these , the origin core , is required only for DNA replication .", + "entities": [] + }, + { + "id": "3898", + "type": "gene", + "text": "Furthermore , this study demonstrates that reduced inotropy with timolol helped uniform local contraction as estimated by the increased LONG / CIRC ratio , a transition that could improve contraction efficacy .", + "entities": [] + }, + { + "id": "3899", + "type": "gene", + "text": "Eighteen patients were untreated , and 8 had been given previous treatment with depot testosterone 100 mg intramuscularly every 2 - 3 weeks for an average duration of 4 . 7 years .", + "entities": [] + }, + { + "id": "3900", + "type": "gene", + "text": "To evaluate the effects of propranolol on myocardial metabolism after coronary reperfusion , serial measurements of myocardial creatine kinase ( CK ) and calcium ( Ca ) contents and CK and lactic acid ( LA ) concentrations in coronary sinus blood were carried out in 33 open - chest dogs .", + "entities": [ + "myocardial creatine kinase", + "CK", + "CK" + ] + }, + { + "id": "3901", + "type": "gene", + "text": "GATA - 1 mRNA was present in equivalent levels in both erythroid cell lines , but at a low level in FDC - P1 cells .", + "entities": [ + "GATA - 1 mRNA" + ] + }, + { + "id": "3902", + "type": "gene", + "text": "To study the in vivo role of p16 . 7 , a phi29 mutant containing a suppressible mutation in gene 16 . 7 was constructed .", + "entities": [ + "p16 . 7", + "gene 16 . 7" + ] + }, + { + "id": "3903", + "type": "gene", + "text": "In addition , C / EBP beta and C / EBP gamma readily heterodimerize with each other as well as with C / EBP alpha .", + "entities": [ + "C / EBP beta", + "C / EBP gamma", + "C / EBP alpha" + ] + }, + { + "id": "3904", + "type": "gene", + "text": "These experiments delineate a 186 - bp , EBNA - 2 - responsive cell DNA fragment and provide firm evidence that EBNA - 2 transactivates transcription of cell genes .", + "entities": [ + "EBNA - 2", + "EBNA - 2" + ] + }, + { + "id": "3905", + "type": "gene", + "text": "The preferential serum IgA response observed in the patient population suggests that bronchial associated lymphoid tissue in the diseased lung is an important source of circulating IgA .", + "entities": [ + "serum IgA", + "IgA" + ] + }, + { + "id": "3906", + "type": "gene", + "text": "To the best of our knowledge , SNTCS is highly malignant .", + "entities": [] + }, + { + "id": "3907", + "type": "gene", + "text": "Site - directed mutagenesis of the traI structural gene and application of purified mutant TraI proteins for in vitro assays served to evaluate the functional importance of conserved amino acid residues .", + "entities": [ + "traI structural gene", + "TraI proteins" + ] + }, + { + "id": "3908", + "type": "gene", + "text": "A transcription factor exclusion assay was used to show that the PCF1 mutation affects two distinct stages in transcription : one prior to and one after stable complex formation ; and that these effects are mediated by a component of the stable complex .", + "entities": [ + "PCF1 mutation" + ] + }, + { + "id": "3909", + "type": "gene", + "text": "Changes in tissue PCO2 were less dramatic and did not vary significantly from those recorded in venous blood .", + "entities": [] + }, + { + "id": "3910", + "type": "gene", + "text": "PATIENTS AND METHODS : This study is a retrospective cohort study of all children with cancer admitted to a single institution with fever and neutropenia ( defined as an absolute neutrophil count < 500 cells / mm3 ) in a 1 - year period .", + "entities": [] + }, + { + "id": "3911", + "type": "gene", + "text": "Gel shift analysis indicates that the full - length ERM protein is able to bind specifically to an oligonucleotide containing the consensus nucleotide core sequence GGAA recognized by the Ets proteins .", + "entities": [ + "full - length ERM protein", + "Ets" + ] + }, + { + "id": "3912", + "type": "gene", + "text": "Regulation of embryonic growth and lysosomal targeting by the imprinted Igf2 / Mpr gene .", + "entities": [ + "Igf2", + "Mpr" + ] + }, + { + "id": "3913", + "type": "gene", + "text": "The mean values of protease activity were significantly higher in the test groups than in the control group at baseline .", + "entities": [] + }, + { + "id": "3914", + "type": "gene", + "text": "A human recombinant cDNA clone that encoded 253 amino acids residues of a zinc - finger protein ( THZif - 1 ) was cloned by screening a cDNA library prepared from human promyelocytic leukemia HL60 cells with synthetic oligodeoxynucleotide probes that corresponded to the amino acid sequences of tryptic peptides derived from the DNA - binding protein specific for the nuclease - hypersensitive element ( NHE ) of the human c - myc gene .", + "entities": [ + "zinc - finger protein", + "THZif - 1", + "nuclease - hypersensitive element", + "NHE", + "human c - myc gene" + ] + }, + { + "id": "3915", + "type": "gene", + "text": "According to the changes of perfusion defects between Ex , RD and ReI images , they were classified into 3 types : Type I ; perfusion defect on the RD image was identical to ReI image ( 75 % ) Type I was divided into 2 subgroups whether perfusion defect at Ex was unchanged ( Ia , 42 % ) or improved ( Ib , 33 % ) on the RD image .", + "entities": [] + }, + { + "id": "3916", + "type": "gene", + "text": "Overall prevalences of antibody were 70 per cent in cattle , 67 per cent in sheep and 76 per cent in goats as assessed by an immunodiffusion test .", + "entities": [] + }, + { + "id": "3917", + "type": "gene", + "text": "The protein sequence contains seven potential N - linked glycosylation sites and a threonine / serine - rich region which is a potential site for attachment of O - linked carbohydrate .", + "entities": [] + }, + { + "id": "3918", + "type": "gene", + "text": "Here we describe the optimization and characterization of a 140 - residue fragment , containing the Runt domain of AML1 , which is suitable for structural studies .", + "entities": [ + "Runt domain", + "AML1" + ] + }, + { + "id": "3919", + "type": "gene", + "text": "Multiple mitogen - activated protein kinase signaling pathways connect the cot oncoprotein to the c - jun promoter and to cellular transformation .", + "entities": [ + "mitogen - activated protein kinase", + "cot oncoprotein", + "c - jun promoter" + ] + }, + { + "id": "3920", + "type": "gene", + "text": "The procedure is less aggressive and painful than sternotomy .", + "entities": [] + }, + { + "id": "3921", + "type": "gene", + "text": "These data demonstrate the presence of a single binding site for vinculin , and at least two binding sites for FAK that are separated by an intervening stretch of 100 amino acids .", + "entities": [ + "vinculin", + "FAK" + ] + }, + { + "id": "3922", + "type": "gene", + "text": "This is the first report of the successful resection of a MFH originating in the renal capsular tissue and extending into the inferior vena cava .", + "entities": [] + }, + { + "id": "3923", + "type": "gene", + "text": "Age at POI and asymptote were achieved later for Line RBC2 than for Line F .", + "entities": [] + }, + { + "id": "3924", + "type": "gene", + "text": "Fewer recombination events are detected in four different B and T cell lines that do not undergo switch recombination of their endogenous genes .", + "entities": [] + }, + { + "id": "3925", + "type": "gene", + "text": "Direct binding and competition assays using 30 - mer oligonucleotide probes representing the individual CBF1 binding sites indicated that CBF1 bound less efficiently to the CD23 promoter and the EBV LMP - 1 promoter sites than to the Cp site .", + "entities": [ + "CBF1 binding sites", + "CBF1", + "CD23 promoter", + "EBV LMP - 1 promoter sites", + "Cp site" + ] + }, + { + "id": "3926", + "type": "gene", + "text": "The % SVend of HCM - I was significantly lower than the respective values of the HCM - II and Control groups .", + "entities": [] + }, + { + "id": "3927", + "type": "gene", + "text": "Hierarchy of protein tyrosine kinases in interleukin - 2 ( IL - 2 ) signaling : activation of syk depends on Jak3 ; however , neither Syk nor Lck is required for IL - 2 - mediated STAT activation .", + "entities": [ + "protein tyrosine kinases", + "interleukin - 2", + "IL - 2", + "syk", + "Jak3", + "Syk", + "Lck", + "IL - 2", + "STAT" + ] + }, + { + "id": "3928", + "type": "gene", + "text": "Mental rotation of paired figures engendered activation in the left superior parietal lobule and the right frontal medial gyrus .", + "entities": [] + }, + { + "id": "3929", + "type": "gene", + "text": "RESULTS : The bovine cDNA insert sequence was 273 nucleotides in length for the entire mRNA coding region , 212 nucleotides in the 5 ' untranslated region , 83 nucleotides in the 3 ' untranslated region and a poly ( A ) tail .", + "entities": [] + }, + { + "id": "3930", + "type": "gene", + "text": "Losartan Intervention For Endpoint .", + "entities": [] + }, + { + "id": "3931", + "type": "gene", + "text": "Management often involves beta - and calcium channel blocking drugs or type IC antiarrhythmic drugs .", + "entities": [] + }, + { + "id": "3932", + "type": "gene", + "text": "Residual urinary abnormalities were significantly more frequent in patients with type III than type I MPGN .", + "entities": [] + }, + { + "id": "3933", + "type": "gene", + "text": "It contains a 5 ' - noncoding region ( NCR ) of 73 nucleotides , five open reading frames ( ORFs 1 to 5 ) which encode proteins with M ( r ) 160 kDa RNA - dependent RNA polymerase ( ORF1 ) , 26 kDa movement protein 1 ( ORF2 ) , 13 kDa movement protein 2 ( ORF3 ) , 10 kDa movement protein 3 ( ORF4 ) , 24 kDa coat protein ( OFR5 ) , and a 3 ' NCR of 76 nucleotides .", + "entities": [ + "160 kDa RNA - dependent RNA polymerase ( ORF1 )", + "26 kDa movement protein 1 ( ORF2 )", + "13 kDa movement protein 2 ( ORF3 )", + "10 kDa movement protein 3 ( ORF4 )", + "24 kDa coat protein ( OFR5 )" + ] + }, + { + "id": "3934", + "type": "gene", + "text": "( 1988 ) J .", + "entities": [] + }, + { + "id": "3935", + "type": "gene", + "text": "We also raised a polyclonal antibody against the glutathione S - transferase fusion protein containing the NH2 - terminal 86 amino acids of human NRAMP2 .", + "entities": [ + "glutathione S - transferase fusion protein", + "human NRAMP2" + ] + }, + { + "id": "3936", + "type": "gene", + "text": "We estimate that the protease activity is at least 35 - fold greater in mature B cells than in pre - B cells .", + "entities": [] + }, + { + "id": "3937", + "type": "gene", + "text": "3D image - processing permits to analyse ultrasound data interactively in three orthogonal planes ( section mode ) or in realistic 3D views ( rendering mode ) .", + "entities": [] + }, + { + "id": "3938", + "type": "gene", + "text": "The linear plasmid pCLU1 from the yeast Kluyveromyces lactis normally replicates in the cytoplasm , with the aid of the helper linear plasmid pGKL2 , using terminal protein ( TP ) as a primer .", + "entities": [ + "terminal protein", + "TP" + ] + }, + { + "id": "3939", + "type": "gene", + "text": "Thus , although p28 may play only a limited role during the early embryonic cleavages , it may function later in development to establish a somatic type of cell cycle .", + "entities": [ + "p28" + ] + }, + { + "id": "3940", + "type": "gene", + "text": "Studies using an inhibitor or a mutant Lb proteinase indicated that stimulation of IRES - driven translation is mediated via proteolysis of some cellular component ( s ) .", + "entities": [ + "mutant Lb proteinase" + ] + }, + { + "id": "3941", + "type": "gene", + "text": "In addition , a wild - type strain containing a temperature - sensitive threonyl - tRNA synthetase mutation showed increased thr operon expression at the non - permissive temperature , whereas none of the mutants showed any change .", + "entities": [ + "temperature - sensitive threonyl - tRNA synthetase mutation", + "thr operon" + ] + }, + { + "id": "3942", + "type": "gene", + "text": "Protein tyrosine kinases ( PTKs ) are implicated in the control of cell growth by virtue of their frequent appearance as products of retroviral oncogenes , as intracellular signal transducers , and as growth factor receptors or components thereof .", + "entities": [ + "Protein tyrosine kinases", + "PTKs", + "growth factor receptors" + ] + }, + { + "id": "3943", + "type": "gene", + "text": "To determine what role eIF4E might play in c - myc expression , the c - myc 5 ' untranslated region ( UTR ) was fused in - frame to CAT reporters , and several more derivative constructs were made .", + "entities": [ + "eIF4E", + "c - myc", + "c - myc 5 ' untranslated region ( UTR )", + "CAT reporters" + ] + }, + { + "id": "3944", + "type": "gene", + "text": "When introduced into recJ + strains , srjA mutations conferred hyperrecombinational and hyper - UVr phenotypes .", + "entities": [ + "recJ +", + "srjA", + "hyper - UVr" + ] + }, + { + "id": "3945", + "type": "gene", + "text": "We report the isolation of human cDNAs homologous to the Drosophila dishevelled ( dsh ) segment - polarity gene .", + "entities": [ + "Drosophila dishevelled", + "dsh" + ] + }, + { + "id": "3946", + "type": "gene", + "text": "The regions of the tooth fracture are determined .", + "entities": [] + }, + { + "id": "3947", + "type": "gene", + "text": "Pharmacological action of eptazocine ( l - 1 , 4 - dimethyl - 10 - hydroxy - 2 , 3 , 4 , 5 , 6 , 7 - hexahydro - 1 , 6 - methano - 1H - 4 - benz azonine ) .", + "entities": [] + }, + { + "id": "3948", + "type": "gene", + "text": "Reverse transcription - PCR was then used to clone from human poly ( A ) + RNA the cDNA corresponding to the expressed homolog of psi ARF 4 , referred to as human ARF 4 .", + "entities": [ + "psi ARF 4", + "human ARF 4" + ] + }, + { + "id": "3949", + "type": "gene", + "text": "S1 nuclease analysis of RNA from chemically induced B95 - 8 cells and from Vero cells cotransfected with NotI repeat promoter - CAT and Z showed that Z transactivation increased the level of correctly initiated , stable RNA transcripts .", + "entities": [ + "S1 nuclease", + "NotI repeat promoter", + "CAT", + "Z", + "Z" + ] + }, + { + "id": "3950", + "type": "gene", + "text": "They were then subjected to whole - body heat stress ( water - perfused suits ) , and the 3 minutes of LBNP was repeated .", + "entities": [] + }, + { + "id": "3951", + "type": "gene", + "text": "This emancipation of the ability to copulate from hormonal influence makes female sexual motivation the primary regulator of mating in primates .", + "entities": [] + }, + { + "id": "3952", + "type": "gene", + "text": "In a similar experiment , simultaneous nitrofurazone administration and S . enteritidis challenge resulted in no significant differences in S . enteritidis isolation frequency .", + "entities": [] + }, + { + "id": "3953", + "type": "gene", + "text": "The effects of procedural variations on lateralized Stroop effects .", + "entities": [] + }, + { + "id": "3954", + "type": "gene", + "text": "Teratogenic effects of actinomycin D in rats", + "entities": [] + }, + { + "id": "3955", + "type": "gene", + "text": "Repair of this insertion by homologous recombination restores the activity of the hprt locus , thus confirming the site of mutation .", + "entities": [ + "hprt locus" + ] + }, + { + "id": "3956", + "type": "gene", + "text": "Comparative study on acute oral overload using tolbutamide and tolazamide in normal and diabetic subjects .", + "entities": [] + }, + { + "id": "3957", + "type": "gene", + "text": "Benefits of obtaining board certification in pharmacotherapy .", + "entities": [] + }, + { + "id": "3958", + "type": "gene", + "text": "Here we suggest that uvrA and the nucleotide excision repair pathway are involved in the repair of acid - induced DNA damage and are associated with successful adaptation of S . mutans to low pH .", + "entities": [ + "uvrA" + ] + }, + { + "id": "3959", + "type": "gene", + "text": "Administration of RIFA at 200 mg / kg / day in combination with ATO at 100 mg / kg / day resulted in a marked prolongation of survival compared with that for mice that received ATO or RIFA alone .", + "entities": [] + }, + { + "id": "3960", + "type": "gene", + "text": "Comparison of data obtained with the results of chronic treatment with the opioid antagonist permits to conclude that the chronic blockade increases the fatiguability to a great extent than chronic activation of opioid system .", + "entities": [] + }, + { + "id": "3961", + "type": "gene", + "text": "Previously , we characterized a DNA - binding protein , HS2NF5 , that bound tightly to a conserved region within hypersensitive site 2 ( HS2 ) of the human beta - globin locus control region ( LCR ) ( Lam , L .", + "entities": [ + "HS2NF5", + "human beta - globin locus control region" + ] + }, + { + "id": "3962", + "type": "gene", + "text": "The pyramidal tract and Mesencephalic Reticular Formation ( MRF ) were stimulated before and after the transection .", + "entities": [] + }, + { + "id": "3963", + "type": "gene", + "text": "RNase protection assays revealed a correlation between the levels of dorsal and ventral skin expression with pigmentation / phaeomelanin phenotypes .", + "entities": [ + "RNase" + ] + }, + { + "id": "3964", + "type": "gene", + "text": "High - resolution computed tomography in the diagnosis of miliary tuberculosis .", + "entities": [] + }, + { + "id": "3965", + "type": "gene", + "text": "The retention index of 201Tl SPECT is a useful indicator of metastatic potential , thereby facilitating the prediction of prognosis , and provides insight into the relationship between 201Tl uptake and malignancy .", + "entities": [] + }, + { + "id": "3966", + "type": "gene", + "text": "Routine psychometric screening of IHD patients may provide a cost - effective means of alerting cardiologists and internists to the relatively high levels of distress among their patients .", + "entities": [] + }, + { + "id": "3967", + "type": "gene", + "text": "II .", + "entities": [] + }, + { + "id": "3968", + "type": "gene", + "text": "Induced expression of c - myc is likely to contribute to the proliferation of Stat1 - null cells in response to IFNs .", + "entities": [ + "c - myc", + "Stat1", + "IFNs" + ] + }, + { + "id": "3969", + "type": "gene", + "text": "Insulin receptor substrate - 1 - mediated enhancement of growth hormone - induced mitogen - activated protein kinase activation .", + "entities": [ + "Insulin receptor substrate - 1", + "growth hormone", + "mitogen - activated protein kinase" + ] + }, + { + "id": "3970", + "type": "gene", + "text": "Eleven strains of Fusarium poae and F . sporotrichioides from the U . S . S . R . and 7 strains of these species and one of F . sporotrichioides var . tricinctum from U . S . A . and France have been compared as to their capacity to yield T - 2 toxin .", + "entities": [ + "T - 2 toxin" + ] + }, + { + "id": "3971", + "type": "gene", + "text": "Cell viability and lysosomal enzymes", + "entities": [] + }, + { + "id": "3972", + "type": "gene", + "text": "Spleen weight in rats during tumour growth and in homograft rejection .", + "entities": [] + }, + { + "id": "3973", + "type": "gene", + "text": "The Wilms ' tumour suppressor protein ( WT1 ) is a putative transcriptional regulatory protein with four zinc fingers , the last three of which have extensive sequence homology to the early growth response - 1 ( EGR - 1 ) protein .", + "entities": [ + "Wilms ' tumour suppressor protein", + "WT1", + "early growth response - 1", + "EGR - 1" + ] + }, + { + "id": "3974", + "type": "gene", + "text": "Our data therefore indicate that it is possible to engineer the HA envelope glycoprotein by fusing ligands to its amino - terminal end without affecting its fusion activity .", + "entities": [ + "HA envelope glycoprotein" + ] + }, + { + "id": "3975", + "type": "gene", + "text": "Very good accuracy ( r greater than 0 . 9 ) was found when except comparing H * 2 with the other machine and the reference methods , except for MCHCH and basophil count .", + "entities": [] + }, + { + "id": "3976", + "type": "gene", + "text": "Soluble FasR ligand - binding domain : high - yield production of active fusion and non - fusion recombinant proteins using the baculovirus / insect cell system .", + "entities": [ + "FasR" + ] + }, + { + "id": "3977", + "type": "gene", + "text": "To avoid misinterpretations , special reference values should be applied for preadolescents , at least with regard to FVC and FEV1 .", + "entities": [] + }, + { + "id": "3978", + "type": "gene", + "text": "Cosmid clones containing both VNTR sequences were identified , and restriction mapping showed them to be less than 15 kb apart .", + "entities": [] + }, + { + "id": "3979", + "type": "gene", + "text": "DNA from PCR was labeled and used to isolate several lambda gt11 cDNA clones , including one full - length one ( Dd kinase - 2 ) .", + "entities": [ + "Dd kinase - 2" + ] + }, + { + "id": "3980", + "type": "gene", + "text": "Letter : Is actinic ( solar ) damage the provoking cause of ' post - inflammatory elastolysis and cutis laxa ( PECL ) ' ?", + "entities": [] + }, + { + "id": "3981", + "type": "gene", + "text": "Consistent with the specificity observed for the interaction of DmCKIIalpha with these bHLH proteins , sequence alignment suggests that only m5 , m7 , and m8 contain a consensus site for phosphorylation by CKII within a subdomain unique to these three proteins .", + "entities": [ + "DmCKIIalpha", + "bHLH proteins", + "m5", + "m7", + "m8", + "CKII" + ] + }, + { + "id": "3982", + "type": "gene", + "text": "These mutations are localized in the same region where the HSV transactivator VP16 binds , but did not coincide with the VP16 contacts .", + "entities": [ + "HSV transactivator VP16", + "VP16" + ] + }, + { + "id": "3983", + "type": "gene", + "text": "Examination of the mitochondrial bc1 complex crystal structure [ Zhang , Z . , Huang , L . , Shulmeister , V .", + "entities": [ + "mitochondrial bc1 complex crystal structure" + ] + }, + { + "id": "3984", + "type": "gene", + "text": "Testing was associated with a history of nonsexual risk behavior , increased knowledge of the hepatitis C virus , and healthcare provider communication .", + "entities": [] + }, + { + "id": "3985", + "type": "gene", + "text": "In the COPD patients , the variability of Delta - inst Rrs ( 30 % ) was greater than that of FOT Rrs ( 21 % ) .", + "entities": [] + }, + { + "id": "3986", + "type": "gene", + "text": "The novel protein kinases , c - Jun NH2 - terminal kinases ( JNKs ) / stress - activated protein kinases , are also activated by TNF - alpha , IL - 1 , and CD28 costimulation .", + "entities": [ + "c - Jun NH2 - terminal kinases", + "JNKs", + "stress - activated protein kinases", + "TNF - alpha", + "IL - 1", + "CD28" + ] + }, + { + "id": "3987", + "type": "gene", + "text": "Whereas Smad2 was rapidly phosphorylated by TGF - beta and involved in the initial activation of Agc expression in confluent cells , Smad2 activation was not required for maintaining the high level of Agc expression .", + "entities": [ + "Smad2", + "TGF - beta", + "Agc", + "Smad2", + "Agc" + ] + }, + { + "id": "3988", + "type": "gene", + "text": "All pigs had significant regional LV dysfunction and reduced LV ejection fraction ( 41 + / - 11 % ) .", + "entities": [] + }, + { + "id": "3989", + "type": "gene", + "text": "Besides , we found in 3 patients increased serum immunoglobulins , chiefly IgG , as first Russe , Busey and Barbeau demonstrated in a large French - Canadian family .", + "entities": [ + "serum immunoglobulins", + "IgG" + ] + }, + { + "id": "3990", + "type": "gene", + "text": "Hepatic oxygen supply and selected blood parameters were recorded in fasted male rates given 20 - - 30 mg / kg Escherichia coli endotoxin intraperitoneally .", + "entities": [ + "Escherichia coli endotoxin" + ] + }, + { + "id": "3991", + "type": "gene", + "text": "Another segment of CRL3 ( - 296 to - 184 ) , also displaying enhancer function , contained tandem repeated sequences ( DR - A1 and DR - A2 ) .", + "entities": [ + "CRL3" + ] + }, + { + "id": "3992", + "type": "gene", + "text": "The xylose isomerase - encoding gene ( xylA ) of Clostridium thermosaccharolyticum : cloning , sequencing and phylogeny of XylA enzymes .", + "entities": [ + "xylose isomerase - encoding gene", + "xylA", + "XylA enzymes" + ] + }, + { + "id": "3993", + "type": "gene", + "text": "Rho GDP / GTP exchange inhibitor , Rho GDI , comigrated with Rac2 and RhoA , but not Rac1 .", + "entities": [ + "Rho GDP / GTP exchange inhibitor", + "Rho GDI", + "Rac2", + "RhoA", + "Rac1" + ] + }, + { + "id": "3994", + "type": "gene", + "text": "The tyrosine - phosphorylated state of CAK beta was not reduced on trypsinization , nor enhanced in response to plating 3Y1 cells onto fibronectin .", + "entities": [ + "CAK beta", + "fibronectin" + ] + }, + { + "id": "3995", + "type": "gene", + "text": "An open reading frame encoding a protein which shows significant similarity to invertases and resolvases was located immediately upstream of the Pac25I R - M operon .", + "entities": [ + "invertases", + "resolvases", + "R - M operon" + ] + }, + { + "id": "3996", + "type": "gene", + "text": "In a 112 - d feedlot trial , 105 heifers were assigned to light , medium and heavy weight blocks on five treatments : dietary MGA ( . 5 mg . hd - 1 . d - 1 ) , control ( no MGA ) or DEPO - MGA on d 1 at . 5 , 1 . 0 or 1 . 5 ml / hd ( 30 , 60 or 90 mg MGA / hd , respectively ) .", + "entities": [] + }, + { + "id": "3997", + "type": "gene", + "text": "Obesity was strongly associated with the proportions of nonprotein - bound and albumin - bound estradiol , and inversely associated with sex hormone binding globulin ( SHBG ) levels and the proportion of SHBG - bound estradiol .", + "entities": [ + "albumin", + "sex hormone binding globulin", + "SHBG", + "SHBG" + ] + }, + { + "id": "3998", + "type": "gene", + "text": "Acta 572 , 113 - 120 ] .", + "entities": [] + }, + { + "id": "3999", + "type": "gene", + "text": "The expression pattern of GL2 , as demonstrated by in situ hybridization , indicated that the gene is expressed in trichome progenitor cells and at stages associated with trichome development .", + "entities": [ + "GL2" + ] + }, + { + "id": "4000", + "type": "gene", + "text": "Radiative corrections to beta decay and the possibility of a fourth generation .", + "entities": [] + }, + { + "id": "4001", + "type": "gene", + "text": "Integrin adhesion receptors transduce signals that control complex cell functions which require the regulation of gene expression , such as proliferation , differentiation and survival .", + "entities": [ + "Integrin adhesion receptors" + ] + }, + { + "id": "4002", + "type": "gene", + "text": "Compared with normal control subjects , all 74 TOF patients had decreased systolic and diastolic myocardial velocities and a longer isovolumic relaxation time .", + "entities": [] + }, + { + "id": "4003", + "type": "gene", + "text": "In fact , SPT activity in the fly expressing epitope - tagged Lace was absorbed by epitope - specific antibody .", + "entities": [ + "SPT", + "Lace" + ] + }, + { + "id": "4004", + "type": "gene", + "text": "Per kg FFM SMR was almost restored to baseline values for the EX group , whereas the non - exercising subjects still showed depressed values ( EX 3 . 7 per cent and D + DE 15 . 8 per cent lower than before treatment ; P less than 0 . 05 ) .", + "entities": [] + }, + { + "id": "4005", + "type": "gene", + "text": "Bailey Instruments and Owen Mumford filaments were the most accurate with 100 % buckling within + / - 1 . 0 g of 10 g .", + "entities": [] + }, + { + "id": "4006", + "type": "gene", + "text": "Tributyltin and its breakdown products , mono - and di - butyltin , were determined in water birds collected from Lake Huron ( the Great Lakes ) , marine coastal United States , and the west coast of British Columbia , Canada .", + "entities": [] + }, + { + "id": "4007", + "type": "gene", + "text": "LMP2A enhances Lyn and Syk ubiquitination in vivo in a fashion that depends on the activity of Nedd4 family members and correlates with destabilization of the Lyn tyrosine kinase .", + "entities": [ + "LMP2A", + "Lyn", + "Syk", + "Nedd4", + "Lyn tyrosine kinase" + ] + }, + { + "id": "4008", + "type": "gene", + "text": "From the 15 - kb clone a 4 - kb EcoRI fragment containing the first two exons and 2 . 6 kb of the 5 ' flanking region of the opn gene was sequenced , and the transcriptional start site determined by primer extension analysis and S1 nuclease mapping .", + "entities": [ + "4 - kb EcoRI fragment", + "opn gene", + "S1 nuclease" + ] + }, + { + "id": "4009", + "type": "gene", + "text": "The effect of salmon calcitonin nasal spray in women with established osteoporosis has also been studied .", + "entities": [ + "salmon calcitonin" + ] + }, + { + "id": "4010", + "type": "gene", + "text": "Superoxide dismutase ( SOD ) activity decreased significantly in sperm subjected to direct electric current in comparison to the control or the sample incubated with electrolyzed medium .", + "entities": [ + "Superoxide dismutase", + "SOD" + ] + }, + { + "id": "4011", + "type": "gene", + "text": "The derivatives of the latter two cell lines showed increased expression of the p27Kip1 protein and inhibition of cell growth .", + "entities": [ + "p27Kip1 protein" + ] + }, + { + "id": "4012", + "type": "gene", + "text": "In all eight cases , neither FL nor DLL cells showed alterations of bcl - 2 gene sequences in the breakpoint region , suggesting high conservation of the bcl - 2 gene during both t ( 14 ; 18 ) translocation and morphologic transformation of the FL cells .", + "entities": [ + "bcl - 2 gene sequences", + "bcl - 2 gene" + ] + }, + { + "id": "4013", + "type": "gene", + "text": "The clinico - pathological data from a patient with irreversible post - partum renal failure ( IPRF ) are presented .", + "entities": [] + }, + { + "id": "4014", + "type": "gene", + "text": "The 1 . 1 - and 1 . 3 - kb mRNA species were found only in the heart , and the 2 . 6 - kb species was found in the heart , kidney and brain , but not in skeletal muscle or liver .", + "entities": [] + }, + { + "id": "4015", + "type": "gene", + "text": "Mg - chelatase of tobacco : identification of a Chl D cDNA sequence encoding a third subunit , analysis of the interaction of the three subunits with the yeast two - hybrid system , and reconstitution of the enzyme activity by co - expression of recombinant CHL D , CHL H and CHL I .", + "entities": [ + "Mg - chelatase", + "Chl D cDNA sequence", + "recombinant CHL D", + "CHL H", + "CHL I" + ] + }, + { + "id": "4016", + "type": "gene", + "text": "To study the functional differences between cutaneous HPV5 and HPV8 E7s and genital HPV16 E7 , we cloned each of the E7 open reading frames and tested their immortalizing and transforming activities , the binding ability of their products with retinoblastoma protein ( RB ) and their complementation activity of a RB - nonbinding adenovirus E1A mutant .", + "entities": [ + "E7s", + "genital HPV16 E7", + "E7", + "retinoblastoma protein", + "RB", + "RB - nonbinding adenovirus E1A mutant" + ] + }, + { + "id": "4017", + "type": "gene", + "text": "The expressed G1 - G2 bound to both hyaluronan and link protein indicating that the immunoglobulin - fold motif and proteoglycan tandem repeat loops of the G1 domain were correctly folded .", + "entities": [ + "G1", + "G2", + "link protein", + "immunoglobulin - fold motif", + "G1 domain" + ] + }, + { + "id": "4018", + "type": "gene", + "text": "Hepatitis B vaccine : still has its problems .", + "entities": [] + }, + { + "id": "4019", + "type": "gene", + "text": "High - resolution structure of the diphtheria toxin repressor complexed with cobalt and manganese reveals an SH3 - like third domain and suggests a possible role of phosphate as co - corepressor .", + "entities": [ + "diphtheria toxin repressor", + "SH3 - like" + ] + }, + { + "id": "4020", + "type": "gene", + "text": "Do overall treatment time , field size , and treatment energy influence local control of T1 - T2 squamous cell carcinomas of the glottic larynx ?", + "entities": [] + }, + { + "id": "4021", + "type": "gene", + "text": "PURPOSE : To evaluate treatment and patient related prognostic factors that may influence local control in the treatment of T1 - T2 squamous cell carcinoma of the glottic larynx .", + "entities": [] + }, + { + "id": "4022", + "type": "gene", + "text": "A review of studies published between 1983 and 1995 shows that there are some common factors as regards the psychological distress and social and functional limitations this group of patients has to deal with .", + "entities": [] + }, + { + "id": "4023", + "type": "gene", + "text": "Contagious bovine pleuropneumonia is a major threat for cattle in Africa .", + "entities": [] + }, + { + "id": "4024", + "type": "gene", + "text": "RNP1 , a new ribonucleoprotein gene of the yeast Saccharomyces cerevisiae .", + "entities": [ + "RNP1" + ] + }, + { + "id": "4025", + "type": "gene", + "text": "The yeast LPD1 gene encoding lipoamide dehydrogenase is subject to the general control of amino acid biosynthesis mediated by the GCN4 transcription factor .", + "entities": [ + "yeast LPD1 gene", + "lipoamide dehydrogenase", + "GCN4 transcription factor" + ] + }, + { + "id": "4026", + "type": "gene", + "text": "Well - visualised arteriograms of the limbs can be obtained by xeroradiography after rapid manual injection of contrast - medium into an arm vein , as demonstrated in 28 patients .", + "entities": [] + }, + { + "id": "4027", + "type": "gene", + "text": "Recent studies have shown that the Src homology - 2 ( SH2 ) domain - containing protein - tyrosine phosphatase , SHP - 2 , associates with the cytoplasmic domain of PECAM - 1 as it becomes tyrosine - phosphorylated during platelet aggregation : a process that can be mimicked in part by small synthetic phosphopeptides corresponding to the cytoplasmic domain of PECAM - 1 encompassing tyrosine residues Tyr - 663 or Tyr - 686 .", + "entities": [ + "Src homology - 2", + "SH2", + "protein - tyrosine phosphatase", + "SHP - 2", + "PECAM - 1", + "PECAM - 1" + ] + }, + { + "id": "4028", + "type": "gene", + "text": "Serum HBV - DNA , viral serology , and liver enzymes were measured sequentially ; liver histology was taken before and during treatment in 12 patients .", + "entities": [] + }, + { + "id": "4029", + "type": "gene", + "text": "NIRS was used for the quantitative measurement of muscle O ( 2 ) consumption ( mV . O ( 2 ) ) and forearm blood flow ( FBF ) in 78 healthy subjects .", + "entities": [] + }, + { + "id": "4030", + "type": "gene", + "text": "CONCLUSION : Our findings suggest that endometriosis increases soluble CD23 levels , which can be suppressed with either danazol or leuprolide acetate injection .", + "entities": [ + "CD23" + ] + }, + { + "id": "4031", + "type": "gene", + "text": "Keck , C . J .", + "entities": [] + }, + { + "id": "4032", + "type": "gene", + "text": "Data on prosthesis use are encouraging , although a follow - up study is required to determine the functional outcome for prosthesis users and non - users .", + "entities": [] + }, + { + "id": "4033", + "type": "gene", + "text": "SPP41 was cloned and sequenced and found to be essential .", + "entities": [ + "SPP41" + ] + }, + { + "id": "4034", + "type": "gene", + "text": "spp43 is allelic to the previously identified suppressor srn1 , which encodes a negative regulator of gene expression .", + "entities": [ + "spp43", + "suppressor srn1" + ] + }, + { + "id": "4035", + "type": "gene", + "text": "The RPO1 of LCDV shows the highest similarity to the RPO1 of IIV6 and significant lower similarity to the eukaryotic polymerases II and III as well as to the archaebacteral subunit .", + "entities": [ + "RPO1", + "RPO1", + "eukaryotic polymerases II and III" + ] + }, + { + "id": "4036", + "type": "gene", + "text": "The human coreceptor was as active as the simian for SIV entry .", + "entities": [] + }, + { + "id": "4037", + "type": "gene", + "text": "The N - terminal domain of approximately 70 kDa exhibits 11 imperfect amino acid repeats that show some homology to promastigote surface glycoproteins of the psa2 / gp46 complex .", + "entities": [ + "psa2", + "gp46" + ] + }, + { + "id": "4038", + "type": "gene", + "text": "Comparison of promoters repressed by c - myc reveals a weak consensus sequence of the initiator ( Inr ) element : TCA ( + 1 ) YYYNY .", + "entities": [ + "c - myc" + ] + }, + { + "id": "4039", + "type": "gene", + "text": "We have identified and characterized a vitamin D response element ( VDRE ) in the promoter of c - fos .", + "entities": [ + "c - fos" + ] + }, + { + "id": "4040", + "type": "gene", + "text": "Nine cases of GBS and five of TM reported to the active AFP surveillance were not found in the hospital searches .", + "entities": [] + }, + { + "id": "4041", + "type": "gene", + "text": "Examination of nuclear magnetic resonance ( NMR ) spectra of a series of N - terminally truncated MIP - 1 beta variants reveals that these proteins possess a range of ability to dimerize .", + "entities": [ + "N - terminally truncated MIP - 1 beta variants" + ] + }, + { + "id": "4042", + "type": "gene", + "text": "Subsequent experiments showed that motoric tasks rather than cognitive aspects of the COWA task were critical in potentiating finger - tapping performance .", + "entities": [] + }, + { + "id": "4043", + "type": "gene", + "text": "The complete exon - intron organization of the murine gene encoding M - protein , a structural protein of sarcomeric myofibrils , was determined .", + "entities": [ + "M - protein" + ] + }, + { + "id": "4044", + "type": "gene", + "text": "The low molecular mass polypeptide complex is assumed to be involved in antigen presentation , generating peptides from cytosolic protein antigens , which are subsequently presented to cytotoxic T - lymphocytes on the cell surface .", + "entities": [] + }, + { + "id": "4045", + "type": "gene", + "text": "The odds ratio for CHD was 1 . 21 ( 95 % confidence interval , 0 . 84 - 1 . 75 ) given a positive serostatus of specific IgG antibodies after adjustment for covariates .", + "entities": [ + "IgG" + ] + }, + { + "id": "4046", + "type": "gene", + "text": "The available data suggest that the NF kappa B2 nucleoprotein complex may cooperate with DNA - bound STAT6 to achieve IL - 4 - dependent activation of the human IgE germline gene .", + "entities": [ + "NF kappa B2 nucleoprotein complex", + "STAT6", + "IL - 4", + "human IgE germline gene" + ] + }, + { + "id": "4047", + "type": "gene", + "text": "Human isoforms , designated 1 to 4 , differ from each other by the start codon used .", + "entities": [] + }, + { + "id": "4048", + "type": "gene", + "text": "Effect of biliary obstruction and cholangitis on serum SPan - 1 level", + "entities": [ + "serum SPan - 1" + ] + }, + { + "id": "4049", + "type": "gene", + "text": "The microdensitometric scores and their side - to - side differences in patients correlated negatively with the serum 25 - OHD concentration and positively with the degree of paralysis .", + "entities": [] + }, + { + "id": "4050", + "type": "gene", + "text": "RESULTS : Acetabular index returned to normal gradually as the time went by and significantly within one year after the reduction of developmental dislocation of the hip .", + "entities": [] + }, + { + "id": "4051", + "type": "gene", + "text": "The paper is concerned with the data on change in the blood level of ACTH , STH , TSH , cortisol , T3 , insulin , C - peptide during a 25 - minute session of respiration using a gaseous hypoxic mixture with 10 % oxygen ( GHM - 10 ) .", + "entities": [ + "ACTH", + "STH", + "TSH", + "insulin", + "C - peptide" + ] + }, + { + "id": "4052", + "type": "gene", + "text": "Human LTBP - 1 is known to exist in different forms .", + "entities": [ + "Human LTBP - 1" + ] + }, + { + "id": "4053", + "type": "gene", + "text": "The cochlear compromise .", + "entities": [] + }, + { + "id": "4054", + "type": "gene", + "text": "Three chromosomal crsA mutations , crsA1 , crsA4 , and crsA47 , were transferred by the \" gene conversion \" process to B . subtilis plasmid pRPD11 , which consists of the entire wild - type rpoD coding sequence , encoding the major sigma 43 factor of B . subtilis RNA polymerase , and pUB110 .", + "entities": [ + "chromosomal crsA mutations", + "crsA1", + "crsA4", + "crsA47", + "wild - type rpoD coding sequence", + "major sigma 43 factor of B . subtilis RNA polymerase" + ] + }, + { + "id": "4055", + "type": "gene", + "text": "In Experiment II , as performing moderate supine cycling ( 55 % VO2 max ) for 50 minutes under several LBNP conditions in 5 sedentary women , there were correspondingly similar changing manners of the cardiovascular adjustments to each of the phases given in Experiment I .", + "entities": [] + }, + { + "id": "4056", + "type": "gene", + "text": "The RNA transcripts structurally equivalent to I ( 2 ) sgRNAs of TMV U1 and crTMV , but containing a hairpin structure ( H ) immediately upstream of IRES ( MP , 75 ) ( HIRES ( MP ) , ( 75 ) ( CR ) - MP - CP - 3 ' UTR ; HIRES ( MP , 75 ) ( U1 ) - MP - CP - 3 ' UTR ) , were able to express the MP gene in vitro .", + "entities": [ + "I ( 2 ) sgRNAs", + "TMV U1", + "IRES ( MP , 75 ) ( HIRES ( MP ) , ( 75 ) ( CR ) - MP - CP - 3 ' UTR", + "HIRES ( MP , 75 ) ( U1 ) - MP - CP - 3 ' UTR", + "MP gene" + ] + }, + { + "id": "4057", + "type": "gene", + "text": "Positive shifts of basal skin potentials during human sleep .", + "entities": [] + }, + { + "id": "4058", + "type": "gene", + "text": "GafChromic ( MD - 55 - 2 ) radiochromic film has become increasingly popular for medical applications and has proven to be useful for brachytherapy dosimetry .", + "entities": [] + }, + { + "id": "4059", + "type": "gene", + "text": "Although olfactory associative conditioning in newborn rats produces marked structural and functional changes in the olfactory bulb , recent evidence suggests that extrabulbar circuits must be involved in storing these early memories .", + "entities": [] + }, + { + "id": "4060", + "type": "gene", + "text": "CYP2C19 genotype was determined by the polymerase chain reaction - restriction fragment length polymorphism method .", + "entities": [ + "CYP2C19 genotype" + ] + }, + { + "id": "4061", + "type": "gene", + "text": "Evolutionary relationships among putative RNA - dependent RNA polymerases encoded by a mitochondrial virus - like RNA in the Dutch elm disease fungus , Ophiostoma novo - ulmi , by other viruses and virus - like RNAs and by the Arabidopsis mitochondrial genome .", + "entities": [ + "RNA - dependent RNA polymerases" + ] + }, + { + "id": "4062", + "type": "gene", + "text": "Abp1 preferentially binds to multiple sites in ARS 3002 and to the DNA polymer poly [ d ( A . T ) ] .", + "entities": [ + "Abp1", + "ARS 3002" + ] + }, + { + "id": "4063", + "type": "gene", + "text": "Both tear volume and tear flow were found to be significantly ( P less than 0 . 001 ) decreased up to 6 h after instillation , reaching a minimum 90 min after application ( tear volume : - 63 % ; tear flow : - 71 % ) .", + "entities": [] + }, + { + "id": "4064", + "type": "gene", + "text": "A population pharmacokinetic study of cyclosporin in organ transplant patients , including elderly allograft recipients up to 75 years of age , did not identify age as a covariable influencing cyclosporin pharmacokinetics .", + "entities": [] + }, + { + "id": "4065", + "type": "gene", + "text": "Primer extension analysis and RNA sequencing demonstrates that the transcription start point of rat ODC mRNA is located 303 nt upstream from the A residue in the start codon .", + "entities": [ + "rat ODC mRNA" + ] + }, + { + "id": "4066", + "type": "gene", + "text": "GRFI bound to sequences at the negative regulatory elements ( silencers ) of the silent mating type loci HML E and HMR E and to the upstream activating sequence ( UAS ) required for transcription of the MAT alpha genes .", + "entities": [ + "GRFI", + "HML E", + "HMR E", + "MAT alpha genes" + ] + }, + { + "id": "4067", + "type": "gene", + "text": "Cumulated maximum lod scores between FRDA and D9S5 and between FRDA and D9S15 are above 36 and 61 , respectively , at a recombination fraction of 0 , indicating that recombination events needed to orient the search of the gene are very difficult to identify and ascertain .", + "entities": [ + "FRDA", + "D9S5", + "FRDA", + "D9S15" + ] + }, + { + "id": "4068", + "type": "gene", + "text": "The smallest of the mini - Mu elements is only 7 . 9 kilobase pairs long , allowing the cloning of DNA fragments of up to 31 . 1 kilobase pairs , and the largest of them is 21 . 7 kilobase pairs , requiring that clones carry insertions of less than 17 . 3 kilobase pairs .", + "entities": [] + }, + { + "id": "4069", + "type": "gene", + "text": "We also mapped a 3 ' - polyadenylation site 504bp downstream of the TGA stop codon , consistent with the 2 . 5kb transcript size .", + "entities": [] + }, + { + "id": "4070", + "type": "gene", + "text": "Its early lesions were characterized by angiomatosis , vasculopathy , and proliferation of synoviocytes and fibroblasts .", + "entities": [] + }, + { + "id": "4071", + "type": "gene", + "text": "Bone and bones .", + "entities": [] + }, + { + "id": "4072", + "type": "gene", + "text": "If this is the case , identification and characterization of transcripts from the Ig loci should permit a better understanding of the gene rearrangement process .", + "entities": [ + "Ig loci" + ] + }, + { + "id": "4073", + "type": "gene", + "text": "Bandshift experiments demonstrate that BmHR3A binds specifically to RORE ( Retinoic acid - related Orphan receptor Response Element ) - like sequences in the promoters of both genes , thus suggesting a direct role for BmHR3A in regulating the expression of BmGATAbeta and ESP genes during vitellogenesis .", + "entities": [ + "BmHR3A", + "RORE", + "Retinoic acid - related Orphan receptor Response Element", + "BmHR3A", + "BmGATAbeta", + "ESP genes" + ] + }, + { + "id": "4074", + "type": "gene", + "text": "Ig heavy chain class switching is directed by cytokines inducing transcription from unrearranged CH genes .", + "entities": [ + "Ig heavy chain", + "CH genes" + ] + }, + { + "id": "4075", + "type": "gene", + "text": "In addition , these patients show both quantitative and qualitative differences in their infectious microbiological spectrum , mainly in clean - contaminated , contaminated and dirty surgical procedures .", + "entities": [] + }, + { + "id": "4076", + "type": "gene", + "text": "This finding suggested that the PI3K - Akt activation pathway plays some role in the antiapoptotic effect of EPO .", + "entities": [ + "PI3K", + "Akt", + "EPO" + ] + }, + { + "id": "4077", + "type": "gene", + "text": "The desirability function is based on the search for a global optimum [ D = f ( Y1 , Y2 , . . . , Yn ) ] by the transformation of the measured property to a dimensionless scale for each criterion .", + "entities": [] + }, + { + "id": "4078", + "type": "gene", + "text": "Both HERV - K type 1 and 2 clones were isolated .", + "entities": [] + }, + { + "id": "4079", + "type": "gene", + "text": "The use of the PLCgamma inhibitory peptide , neomycin and the calcium chelator BAPTA - AM on oocytes expressing FGFR1 or the stimulation by PDGF - BB of oocytes expressing PDGFR - FGFR1 mutated on the PLCgamma binding site , prevented GVBD and ERK2 phosphorylation .", + "entities": [ + "PLCgamma inhibitory peptide", + "FGFR1", + "PDGF - BB", + "PDGFR", + "FGFR1", + "PLCgamma binding site", + "ERK2" + ] + }, + { + "id": "4080", + "type": "gene", + "text": "Acetoin can be reused by the bacteria during stationary phase when other carbon sources have been depleted .", + "entities": [] + }, + { + "id": "4081", + "type": "gene", + "text": "The therapy time to deliver the NCS therapeutic dose of 10000 RBE - cGy , is 27 times longer when 157Gd is used instead of 10B .", + "entities": [] + }, + { + "id": "4082", + "type": "gene", + "text": "As normal B cells also present this variant , the mechanism of CD79b posttranscriptional regulation might reflect the activation stage of the normal B cell from which B - CLL derives .", + "entities": [ + "CD79b" + ] + }, + { + "id": "4083", + "type": "gene", + "text": "( 1991 ) .", + "entities": [] + }, + { + "id": "4084", + "type": "gene", + "text": "C .", + "entities": [] + }, + { + "id": "4085", + "type": "gene", + "text": "13 men with a history of recurrent genital herpes simplex virus type 2 ( HSV - 2 ) infection were followed daily for 4 weeks with samples taken from the urethra for virus isolation .", + "entities": [] + }, + { + "id": "4086", + "type": "gene", + "text": "RESULTS : The diagnostic quality of FDG images was at least as good as that of their Tl - 201 counterparts , with less liver background in all but one FDG study .", + "entities": [] + }, + { + "id": "4087", + "type": "gene", + "text": "When two determinations were performed on 12 samples of plasma taken from normal adults in October , the values were 22 . 6 + / - 4 . 8 and 21 . 0 + / - 3 . 6 ( mean + / - SD ) ng / ml , respectively .", + "entities": [] + }, + { + "id": "4088", + "type": "gene", + "text": "In this paper , such lesions in two cases were evaluated by ultrasonography .", + "entities": [] + }, + { + "id": "4089", + "type": "gene", + "text": "Cbl constitutively interacts with the SH3 domains of Grb2 , with a preference for the amino - terminal domain , and is in this way recruited to Shc upon BCR stimulation .", + "entities": [ + "Cbl", + "SH3 domains", + "Grb2", + "Shc", + "BCR" + ] + }, + { + "id": "4090", + "type": "gene", + "text": "A 1 . 5 - kb HindIII genomic fragment carrying the vspA gene from M . bovis PG45 was cloned and sequenced .", + "entities": [ + "HindIII", + "vspA" + ] + }, + { + "id": "4091", + "type": "gene", + "text": "Moreover , an in vitro pull - down assay showed that Os ; CycH ; 1 specifically bound to R2 but not to other rice CDKs .", + "entities": [ + "Os ; CycH ; 1", + "R2", + "rice CDKs" + ] + }, + { + "id": "4092", + "type": "gene", + "text": "Early cirrhosis , an early modality of the evolution of acute hepatitis .", + "entities": [] + }, + { + "id": "4093", + "type": "gene", + "text": "IL - 2 is accepted as a standard treatment used alone , or in combination with chemotherapy or biotherapy in the management of metastatic melanoma and metastatic renal cell carcinoma .", + "entities": [ + "IL - 2" + ] + }, + { + "id": "4094", + "type": "gene", + "text": "Alveolar lymphocytes were surprisingly increased in most patients with AIDS ( mean 26 . 1 + / - 21 . 9 % ; range 1 - 76 % ) and CGL ( mean 26 . 6 + / - 22 . 6 % ; range 3 - 76 % ) with criteria of activation contrasting with the blood lymphopenia .", + "entities": [] + }, + { + "id": "4095", + "type": "gene", + "text": "After peripheral administration of both CRF and TRH , ACTH levels were significantly higher on the tumor side in all patients .", + "entities": [ + "CRF", + "TRH", + "ACTH" + ] + }, + { + "id": "4096", + "type": "gene", + "text": "The presence of visna - maedi in Italy is reported for the first time .", + "entities": [] + }, + { + "id": "4097", + "type": "gene", + "text": "The subjects of the study were 10 normal subjects and 64 patients with gastroduodenal disease .", + "entities": [] + }, + { + "id": "4098", + "type": "gene", + "text": "Altogether , our results indicate that the transcriptional activity of Cut proteins is modulated by PKC .", + "entities": [ + "Cut proteins", + "PKC" + ] + }, + { + "id": "4099", + "type": "gene", + "text": "( 3 ) This effect occurs without removing TRs from the TRE .", + "entities": [ + "TRs" + ] + }, + { + "id": "4100", + "type": "gene", + "text": "Acute effects of LI 160 ( extract of Hypericum perforatum , St John ' s wort ) and two of its constituents on neuroendocrine responses in the rat .", + "entities": [] + }, + { + "id": "4101", + "type": "gene", + "text": "Greater rupture force was required in the adult pigs than in the young pigs .", + "entities": [] + }, + { + "id": "4102", + "type": "gene", + "text": "The kinase activity of PfPK6 is sensitive to CDK inhibitors such as olomoucine and roscovitine .", + "entities": [ + "PfPK6", + "CDK" + ] + }, + { + "id": "4103", + "type": "gene", + "text": "Angina haemorrhagica bullosa causing respiratory obstruction postoperatively .", + "entities": [] + }, + { + "id": "4104", + "type": "gene", + "text": "Interestingly , highly charged residues were abundantly possessed in the carboxy - terminal part of the MDV2 UL10 protein .", + "entities": [ + "MDV2 UL10 protein" + ] + }, + { + "id": "4105", + "type": "gene", + "text": "We and others have demonstrated that the c - cbl proto - oncogene product is one of the earliest targets of tyrosine phosphorylation upon T cell receptor stimulation .", + "entities": [ + "c - cbl proto - oncogene product", + "T cell receptor" + ] + }, + { + "id": "4106", + "type": "gene", + "text": "INTERVENTIONS : Subcutaneous tissue PO2 and PCO2 tensions were measured directly in patients with necrotising fasciitis and in healthy volunteers during normobaric and hyperbaric conditions .", + "entities": [] + }, + { + "id": "4107", + "type": "gene", + "text": "The platelet adhesion rate on these layers were tested concerning the valuation of the haemocompatibility of the basic - polymers polyurethane ( PUR ) , polyvinylchloride ( PVC ) , and polystyrene ( PS ) in two different worked test chambers .", + "entities": [] + }, + { + "id": "4108", + "type": "gene", + "text": "It is suggested that the observed clinical phenomena in response to morphine can be explained by differences in expression and sensitivity of some opioid receptor subtypes in migraine .", + "entities": [ + "opioid receptor" + ] + }, + { + "id": "4109", + "type": "gene", + "text": "Systemic lupus erythematosus was diagnosed .", + "entities": [] + }, + { + "id": "4110", + "type": "gene", + "text": "Parodoxical rise in urinary albumin levels after treatment of essential hypertension .", + "entities": [ + "urinary albumin" + ] + }, + { + "id": "4111", + "type": "gene", + "text": "In summary , the no - adverse - effect - level for this study was determined to be 1000 ppm , based on decreased weight gain in female rats , and on slight organ weight changes in both sexes at 3000 ppm .", + "entities": [] + }, + { + "id": "4112", + "type": "gene", + "text": "Mean intake of vitamin A amounted to 1 . 1 and 0 . 9 mg RE / day for men and women , respectively ; the contributions of meat , fats and oils , vegetables and dairy products to total intake were 35 % , 24 % , 16 % , and 16 % , respectively .", + "entities": [] + }, + { + "id": "4113", + "type": "gene", + "text": "Renal pathology and long - term outcome in childhood SLE .", + "entities": [] + }, + { + "id": "4114", + "type": "gene", + "text": "Persistence of toxaphene in treated lakes .", + "entities": [] + }, + { + "id": "4115", + "type": "gene", + "text": "Domains I and II of B \" are buried upon assembly of the TFIIIB - DNA complex , as determined by protein footprinting .", + "entities": [ + "B \"", + "TFIIIB - DNA complex" + ] + }, + { + "id": "4116", + "type": "gene", + "text": "In endemic BL , the RB2 / p130 gene is mutated in most of the cases , and the protein is restricted to the cytoplasm .", + "entities": [ + "RB2", + "p130" + ] + }, + { + "id": "4117", + "type": "gene", + "text": "2 - Chemical occlusion of vas is quite effective in producing a block in the vas deferens of dogs .", + "entities": [] + }, + { + "id": "4118", + "type": "gene", + "text": "According to pilot experiments which considered various durations of global no - flow ischemia ranging from 10 to 20 minutes , two durations were chosen for the present study : 20 minutes ( group 20 ) in which ventricular fibrillation ( VF ) was the predominant form of arrhythmias , and 18 minutes ( group 18 ) in which the prevalence of VF was markedly lower despite the small difference in the duration of ischemia .", + "entities": [] + }, + { + "id": "4119", + "type": "gene", + "text": "With only purified T antigen in the presence of topoisomerase I to unwind purified DNA , ori - auxiliary sequences strongly facilitated T - antigen - dependent DNA conformational changes consistent with melting the first 50 base pairs .", + "entities": [ + "T antigen", + "topoisomerase I", + "T - antigen" + ] + }, + { + "id": "4120", + "type": "gene", + "text": "Salivary estradiol 17 beta ( E2 - 17 beta ) and progesterone ( P ) were determined by using radioimmunoassay techniques in 30 pregnant females in the first , second and third trimesters as well as in 10 non - pregnant controls during the luteal phase of the menstrual cycle .", + "entities": [] + }, + { + "id": "4121", + "type": "gene", + "text": "Spectrophotometric microanalysis of ethylenediaminotetracetic acid in pharmaceutical preparations", + "entities": [] + }, + { + "id": "4122", + "type": "gene", + "text": "State - approved schools of nursing R . N .", + "entities": [] + }, + { + "id": "4123", + "type": "gene", + "text": "We have recently discovered that CCAAAT / enhancer - binding protein - beta ( C / EBP - beta ) induces gene transcription through a novel IFN response element called the gamma - IFN - activated transcriptional element", + "entities": [ + "CCAAAT / enhancer - binding protein - beta", + "C / EBP - beta", + "IFN response element" + ] + }, + { + "id": "4124", + "type": "gene", + "text": "Antibodies specific to rE12 and rNFIL - 6 disrupt nucleoprotein complexes with these DNA - binding sites , confirming the interaction of native in vivo factors .", + "entities": [ + "rE12", + "rNFIL - 6" + ] + }, + { + "id": "4125", + "type": "gene", + "text": "In this study , the abilities of constitutive and conditional forms of the three Raf kinases to abrogate the cytokine dependency of FDC - P1 cells were examined .", + "entities": [ + "Raf kinases" + ] + }, + { + "id": "4126", + "type": "gene", + "text": "However , when directed to the nucleosome by fusion to core histone H2A or H2B , the non - histone tail forms an MCB that appears identical to that of the endogenous protein .", + "entities": [ + "core histone H2A", + "H2B", + "histone" + ] + }, + { + "id": "4127", + "type": "gene", + "text": "In Ka13 cells , CoCl ( 2 ) stimulated expression of a luciferase reporter gene under the control of a 15 - kilobase pair mouse ho - 1 promoter ( pHO15luc ) .", + "entities": [ + "luciferase reporter gene", + "15 - kilobase pair mouse ho - 1 promoter", + "pHO15luc" + ] + }, + { + "id": "4128", + "type": "gene", + "text": "OBJECTIVE : 1998 Surveillance , Epidemiology , and End Results ( SEER ) data estimate an 83 . 1 % 5 - year survival rate for corpus uteri adenocarcinoma FIGO stage II .", + "entities": [] + }, + { + "id": "4129", + "type": "gene", + "text": "The thrombolytic effects of native tissue - type plasminogen activator ( AK - 124 ) on experimental canine coronary thrombosis .", + "entities": [ + "tissue - type plasminogen activator", + "AK - 124" + ] + }, + { + "id": "4130", + "type": "gene", + "text": "Statement on the development of guidelines for the prevention of AIDS transmission in the workplace .", + "entities": [] + }, + { + "id": "4131", + "type": "gene", + "text": "The members of the Myb family of transcription factors are defined by homology in the DNA - binding domain ; all bind the Myb - binding site ( MBS ) sequence ( YG ( A / G ) C ( A / C / G ) GTT ( G / A ) ) .", + "entities": [ + "Myb family of transcription factors", + "Myb - binding site", + "MBS" + ] + }, + { + "id": "4132", + "type": "gene", + "text": "KAR1 encodes an essential component of the yeast spindle pole body ( SPB ) that is required for karyogamy and SPB duplication .", + "entities": [ + "KAR1" + ] + }, + { + "id": "4133", + "type": "gene", + "text": "An intralobar change in temperature above or below 36 degrees C decreases only the lobar bronchial blood flow and does not influence blood flow to other nearby tissues including those vascularized by the bronchial circulation .", + "entities": [] + }, + { + "id": "4134", + "type": "gene", + "text": "This molecule , wH22xeGFP , consists of the entire humanized anti - FcgammaRI mAb H22 with eGFP genetically fused to the C - terminal end of each CH3 domain .", + "entities": [ + "wH22xeGFP", + "H22", + "eGFP", + "CH3 domain" + ] + }, + { + "id": "4135", + "type": "gene", + "text": "wH22xeGFP binds within the ligand - binding region by its Fc end , as well as outside the ligand - binding region by its Fab ends , thereby cross - linking FcgammaRI .", + "entities": [ + "wH22xeGFP", + "Fc", + "Fab", + "FcgammaRI" + ] + }, + { + "id": "4136", + "type": "gene", + "text": "Interestingly , the CYP71D20 - encoded enzyme activity was capable of converting both 5 - epi - aristolochene and 1 - deoxycapsidiol to capsidiol in vitro , consistent with the notion that this P450 enzyme catalyzes both hydroxylations of its hydrocarbon substrate .", + "entities": [ + "CYP71D20 - encoded enzyme", + "P450 enzyme" + ] + }, + { + "id": "4137", + "type": "gene", + "text": "METHODS : TBN measurements were performed in 31 female outpatients with breast carcinoma who were undergoing standard cyclophosphamide , methotrexate , and 5 - fluorouracil ( CMF ) - based chemotherapy ( median age , 48 years ; range , 26 - 77 years ) .", + "entities": [] + }, + { + "id": "4138", + "type": "gene", + "text": "Comparison with a recently described c - sis cDNA clone ( Collins et al . , Nature 316 , 748 - 750 ( 1985 ) ) revealed that the 1 . 9 kbp DNA region contained a large 5 ' c - sis exon of at least 1050 bp .", + "entities": [ + "c - sis cDNA clone", + "5 ' c - sis exon" + ] + }, + { + "id": "4139", + "type": "gene", + "text": "Members of the C / EBP family of basic - leucine zipper ( bZip ) transcription factors form heterodimers and bind to the CAAT box and other sequence - related enhancer motifs .", + "entities": [ + "C / EBP family", + "basic - leucine zipper ( bZip ) transcription factors" + ] + }, + { + "id": "4140", + "type": "gene", + "text": "In all tissues examined only transcripts positive for insert 3 , an 18 bp insertion in repeat 21 , were amplified , even under conditions in which a 30 % level of insert 3 negative transcript could be easily detected in artificially prepared control samples .", + "entities": [] + }, + { + "id": "4141", + "type": "gene", + "text": "Plasma leptin concentrations were higher in women than men , even after the adjustment for differences in fat mass ( 28 + / - 3 ng / ml for women vs .", + "entities": [ + "Plasma leptin" + ] + }, + { + "id": "4142", + "type": "gene", + "text": "Systemic impact of risk - sharing arrangements .", + "entities": [] + }, + { + "id": "4143", + "type": "gene", + "text": "A lambda gt10 cDNA library was constructed from poly ( A ) + RNA of young green leaves of spinach .", + "entities": [] + }, + { + "id": "4144", + "type": "gene", + "text": "Transduction of the human leukemic cell line K562 showed that viral MRP1 - PG13 supernatants routinely transfer the MRP1 gene to approximately 35 % of target K562 cells , of which at least one third are capable of proliferating in the presence of otherwise toxic concentrations of etoposide .", + "entities": [ + "MRP1", + "MRP1 gene" + ] + }, + { + "id": "4145", + "type": "gene", + "text": "The relative risk of graft loss after conversion to azathioprine compared with graft loss after conversion to azathioprine compared with cyclosporin maintenance was 0 . 71 ( 0 . 37 - 1 . 38 ) and the relative risk of patient death was 0 . 57 ( 0 . 23 - 1 . 41 ) .", + "entities": [] + }, + { + "id": "4146", + "type": "gene", + "text": "RESULTS : The analyzed fragment has significant activity in EpCAM positive cells , and it is regulated negatively by tumor necrosis factor alpha ( TNFalpha ) .", + "entities": [ + "EpCAM", + "tumor necrosis factor alpha", + "TNFalpha" + ] + }, + { + "id": "4147", + "type": "gene", + "text": "Surprisingly , nuclear forms of IE110 were found to move a cytoplasmic form of IE175 into nuclear punctate structures , and a cytoplasmic form of IE110 was able to retain nuclear forms of IE175 in cytoplasmic punctate structures .", + "entities": [ + "IE110", + "IE175", + "IE110", + "IE175" + ] + }, + { + "id": "4148", + "type": "gene", + "text": "These findings suggest that an intracellular WT - 1 / HSAL2 pathway may play a role in development and hematopoiesis .", + "entities": [ + "WT - 1", + "HSAL2" + ] + }, + { + "id": "4149", + "type": "gene", + "text": "Far from this being the case , however , the measurement of apo B has met every reasonable standard of laboratory precision and reliability to allow its widespread introduction in clinical laboratories .", + "entities": [ + "apo B" + ] + }, + { + "id": "4150", + "type": "gene", + "text": "A drug with ISA \" down regulates \" beta receptors ; thus , when the drug is withdrawn there is no post - beta - blocking drug hypersensitivity in contrast to agents without ISA .", + "entities": [ + "beta receptors" + ] + }, + { + "id": "4151", + "type": "gene", + "text": "Routinely collected , processed and stored breast cancer tissue blocks recovered from the archives of the Pathology laboratory in Dar es Salaam after storage of up to 3 years were analysed by a flow cytometry for DNA ploidy and S - phase fraction .", + "entities": [] + }, + { + "id": "4152", + "type": "gene", + "text": "Large - scale sequencing of two regions in human chromosome 7q22 : analysis of 650 kb of genomic sequence around the EPO and CUTL1 loci reveals 17 genes .", + "entities": [ + "EPO", + "CUTL1 loci" + ] + }, + { + "id": "4153", + "type": "gene", + "text": "Two basic patterns of locomotor behavior and corresponding torso morphology exist among extant anthropoids .", + "entities": [] + }, + { + "id": "4154", + "type": "gene", + "text": "Specific requirements for branched - chain amino acids , glutamine , and arginine are evaluated .", + "entities": [] + }, + { + "id": "4155", + "type": "gene", + "text": "The abundance of transcripts from several unrelated genes is decreased in cdc68 - 1 mutant cells after transfer to the restrictive temperature , while at least one transcript , from the HSP82 gene , persists in an aberrant fashion .", + "entities": [ + "cdc68 - 1 mutant", + "HSP82 gene" + ] + }, + { + "id": "4156", + "type": "gene", + "text": "PATIENTS AND METHODS : Between June 1991 and December 1996 , we administered the nucleoside analog 2 - chlorodeoxyadenosine ( 2 - CDA ) to 73 children with primary AML and 20 children with secondary AML or myelodysplastic syndrome ( MDS ) .", + "entities": [] + }, + { + "id": "4157", + "type": "gene", + "text": "TAR and Sp1 - independent transactivation of HIV long terminal repeat by the Tat protein in the presence of human cytomegalovirus IE1 / IE2 .", + "entities": [ + "TAR", + "Sp1", + "HIV long terminal repeat", + "Tat protein", + "IE1", + "IE2" + ] + }, + { + "id": "4158", + "type": "gene", + "text": "Ultimate strengthes seem to be reached for cast cobalt alloys , whereas titanium alloys , such as Ta 6 V , present very high fatigue limit under corrosion .", + "entities": [] + }, + { + "id": "4159", + "type": "gene", + "text": "Both groups then underwent hypnotic induction , and completed the test again ( R2 ) .", + "entities": [] + }, + { + "id": "4160", + "type": "gene", + "text": "A complementary study , showing a good agreement between surface and oesophageal EMGd seems to confirm that surface EMGd is a useful and promising tool for clinical investigation .", + "entities": [] + }, + { + "id": "4161", + "type": "gene", + "text": "We observed NP / NMP4 / CIZ expression in osteocytes , osteoblasts , and chondrocytes in rat bone .", + "entities": [ + "NP", + "NMP4", + "CIZ" + ] + }, + { + "id": "4162", + "type": "gene", + "text": "The alternative sigma factor sigmaB in Staphylococcus aureus : regulation of the sigB operon in response to growth phase and heat shock", + "entities": [ + "sigma factor sigmaB in Staphylococcus aureus", + "sigB operon" + ] + }, + { + "id": "4163", + "type": "gene", + "text": "Rearrangements of the NFKB2 gene are associated with lymphoid malignancies , but the functional significance of these alterations is not known .", + "entities": [ + "NFKB2 gene" + ] + }, + { + "id": "4164", + "type": "gene", + "text": "Sequence analysis of the 47 - kilodalton major integral membrane immunogen of Treponema pallidum .", + "entities": [ + "47 - kilodalton major integral membrane immunogen of Treponema pallidum" + ] + }, + { + "id": "4165", + "type": "gene", + "text": "A novel pleckstrin homology - related gene family defined by Ipl / Tssc3 , TDAG51 , and Tih1 : tissue - specific expression , chromosomal location , and parental imprinting .", + "entities": [ + "pleckstrin homology - related gene family", + "Ipl", + "Tssc3", + "TDAG51", + "Tih1" + ] + }, + { + "id": "4166", + "type": "gene", + "text": "Thus the present data also suggest that BP and HR measurements are influenced not only by state - dependent factors but also by at least three different factors that are each independent of the state : one leads to BP and HR values that are influenced by the cycle the animal is in and the other two influence , respectively , the ranking of the individual ' s BP and HR levels within the population .", + "entities": [] + }, + { + "id": "4167", + "type": "gene", + "text": "Most patients harboring metronidazole - and clarithromycin - resistant strains were eradicated at an equal rate by each of the three regimens .", + "entities": [] + }, + { + "id": "4168", + "type": "gene", + "text": "METHODS : The most distal muscle fibres from the deep and superficial finger flexors were measured relative to the pisiform bone in 18 cadaveric specimens .", + "entities": [] + }, + { + "id": "4169", + "type": "gene", + "text": "We found that the SOCS box interacted with Cullin - 2 and promoted ubiquitination of TEL - JAK2 .", + "entities": [ + "SOCS box", + "Cullin - 2", + "TEL", + "JAK2" + ] + }, + { + "id": "4170", + "type": "gene", + "text": "We confirmed the interaction between TLS and p65 by the pull - down assay in vitro and by a coimmunoprecipitation experiment followed by Western blot of the cultured cell in vivo .", + "entities": [ + "TLS", + "p65" + ] + }, + { + "id": "4171", + "type": "gene", + "text": "Our results suggested that the hexamer and the octamer motifs may play important role ( s ) in regulation of replication - dependent but not of replication - independent expression of the wheat histone H3 gene .", + "entities": [ + "wheat histone H3 gene" + ] + }, + { + "id": "4172", + "type": "gene", + "text": "Two distinct recessive susceptibility loci for vasculitis were mapped on chromosome ( Chr ) 4 at D4Mit89 and D4Mit147 in both progenies .", + "entities": [ + "D4Mit89", + "D4Mit147" + ] + }, + { + "id": "4173", + "type": "gene", + "text": "Restarting time was not affected by magnesium cardioplegia .", + "entities": [] + }, + { + "id": "4174", + "type": "gene", + "text": "In the mouse , both genes reside in the syntenic region 8E1 on chromosome 8 .", + "entities": [] + }, + { + "id": "4175", + "type": "gene", + "text": "Functional analysis of aryl hydrocarbon receptor nuclear translocator interactions with aryl hydrocarbon receptor in the yeast two - hybrid system .", + "entities": [ + "aryl hydrocarbon receptor nuclear translocator", + "aryl hydrocarbon receptor" + ] + }, + { + "id": "4176", + "type": "gene", + "text": "Isolation of tha avian reticuloendothelial virus ( strain T ) .", + "entities": [] + }, + { + "id": "4177", + "type": "gene", + "text": "The patients in one group had intrauterine catheters inserted and oxytocin was titrated to achieve the 75th percentile of uterine activity observed in spontaneous normal labour according to parity .", + "entities": [ + "oxytocin" + ] + }, + { + "id": "4178", + "type": "gene", + "text": "Amiodarone , seldom used as first - line treatment , appears to be the most effective drug .", + "entities": [] + }, + { + "id": "4179", + "type": "gene", + "text": "We have cloned a kinase , Nlk , that is a murine homolog of the Drosophila nemo ( nmo ) gene .", + "entities": [ + "Nlk", + "murine homolog of the Drosophila nemo", + "nmo" + ] + }, + { + "id": "4180", + "type": "gene", + "text": "MpB GroEL has extensive sequence similarity ( 92 % ) with Escherichia coli GroEL and other members of the chaperonin - 60 family .", + "entities": [ + "MpB GroEL", + "Escherichia coli GroEL", + "chaperonin - 60 family" + ] + }, + { + "id": "4181", + "type": "gene", + "text": "The patients and their families were closely questioned , and full clinical examination included a test for orthostasia .", + "entities": [] + }, + { + "id": "4182", + "type": "gene", + "text": "Like DNA binding , transcriptional enhancement required amino - terminally located basic amino acid residues but not the carboxyl - terminal portion of Hap46 known to participate in hsp70 interaction .", + "entities": [ + "Hap46", + "hsp70" + ] + }, + { + "id": "4183", + "type": "gene", + "text": "A new generation of information retrieval tools for biologists : the example of the ExPASy WWW server .", + "entities": [] + }, + { + "id": "4184", + "type": "gene", + "text": "The purified recombinant enzyme catalyzed specific phosphoryl transfer from ATP to UMP and CMP .", + "entities": [] + }, + { + "id": "4185", + "type": "gene", + "text": "Position 22 is an isoleucine in the complete SsoL12 protein sequence , coded by an AUA codon .", + "entities": [ + "complete SsoL12 protein sequence" + ] + }, + { + "id": "4186", + "type": "gene", + "text": "In doses of 0 . 03 - 0 . 3 mg / kg i . v . , SG - 75 did not significantly affect pulse pressure , heart rate , aortic blood flow , left ventricular pressure ( LVP ) and LVdP / dt max .", + "entities": [] + }, + { + "id": "4187", + "type": "gene", + "text": "It is concluded that the plasma prolactin response to 12 . 5 micrograms i . v .", + "entities": [ + "plasma prolactin" + ] + }, + { + "id": "4188", + "type": "gene", + "text": "Structural analysis of the 5 ' - regulatory region reveals that the c - met promoter lacks TATA or CAAT elements but has an extremely high G - C content and multiple Sp1 binding sites .", + "entities": [ + "c - met promoter", + "Sp1 binding sites" + ] + }, + { + "id": "4189", + "type": "gene", + "text": "Magnetic resonance imaging in coccidioidal arthritis .", + "entities": [] + }, + { + "id": "4190", + "type": "gene", + "text": "Transcriptional activation by the HIV - 1 Tat protein requires specific residues in the hexanucleotide loop and trinucleotide bulge of the TAR RNA stem - loop structure found in the 5 ' - untranslated leader of all viral transcripts .", + "entities": [ + "HIV - 1 Tat protein", + "TAR" + ] + }, + { + "id": "4191", + "type": "gene", + "text": "These transcripts contain the 5 ' ends of mature UbCRBP mRNAs ; extend through UbCRBP , across the intergenic region , and a significant distance 3 ' into the enolase gene .", + "entities": [ + "UbCRBP mRNAs", + "UbCRBP", + "enolase gene" + ] + }, + { + "id": "4192", + "type": "gene", + "text": "The Saccharomyces cerevisiae APS1 gene encodes a homolog of the small subunit of the mammalian clathrin AP - 1 complex : evidence for functional interaction with clathrin at the Golgi complex .", + "entities": [ + "Saccharomyces cerevisiae APS1 gene", + "AP - 1 complex", + "clathrin" + ] + }, + { + "id": "4193", + "type": "gene", + "text": "Finally , Cas existed mainly in cytosol and membrane cytoskeleton fractions in the resting state , and remained unchanged during platelet aggregation , when FAK translocated to the cytoskeletal fraction .", + "entities": [ + "Cas", + "FAK" + ] + }, + { + "id": "4194", + "type": "gene", + "text": "On Cox proportional hazards regression adenocarcinoma ( P = 0 . 006 ) , the development of BPF ( P = 0 . 003 ) , older age ( P = 0 . 03 ) and higher pathological stage ( P = 0 . 02 ) were independent adverse predictors of survival .", + "entities": [] + }, + { + "id": "4195", + "type": "gene", + "text": "Interestingly , following induction of stress by heat shock , high salt , or ethanol , conditions under which most mRNA export is blocked , Npl3p is still exported from the nucleus .", + "entities": [ + "Npl3p" + ] + }, + { + "id": "4196", + "type": "gene", + "text": "Many canonical TATA sequences are present upstream from these VZV transcriptional start sites but , apparently , are not used .", + "entities": [] + }, + { + "id": "4197", + "type": "gene", + "text": "When O2 therapy was controlled for , the association between RBT and RLF did not achieve statistical significance ( P = . 07 ) .", + "entities": [] + }, + { + "id": "4198", + "type": "gene", + "text": "An analysis of sequence of the mutant recN gene revealed a G : C to T : A transversion near the 3 ' end of the coding region .", + "entities": [ + "mutant recN gene" + ] + }, + { + "id": "4199", + "type": "gene", + "text": "Unexpectedly , ALK7 signaling produced a remarkable change in cell morphology characterized by cell flattening and elaboration of blunt , short cell processes .", + "entities": [ + "ALK7" + ] + }, + { + "id": "4200", + "type": "gene", + "text": "Identification and characterization of IS2404 and IS2606 : two distinct repeated sequences for detection of Mycobacterium ulcerans by PCR .", + "entities": [ + "IS2404", + "IS2606" + ] + }, + { + "id": "4201", + "type": "gene", + "text": "Regulation of HIV - 1 transcription .", + "entities": [] + }, + { + "id": "4202", + "type": "gene", + "text": "There was a statistically significant correlation between simultaneous weekly average pollen levels in Philadelphia and in Cherry Hill ( Acer , r ( p ) = 0 . 987 , Quercus , r ( p ) = 0 . 645 , Betula , r ( p ) = 0 . 896 , Pinus , r ( p ) = 0 . 732 , Cupressaceae , r ( p ) = 0 . 695 , Poaceae , r ( p ) = 0 . 950 , Ambrosia , r ( p ) = 0 . 903 , and Rumex , r ( p ) = 0 . 572 , P < 0 . 001 ) .", + "entities": [] + }, + { + "id": "4203", + "type": "gene", + "text": "REM sleep deprivation was performed using the platform technique .", + "entities": [] + }, + { + "id": "4204", + "type": "gene", + "text": "If hnRNP K is a transcription factor , then interactions with the RNA polymerase II transcription apparatus are predicted .", + "entities": [ + "hnRNP K", + "RNA polymerase II" + ] + }, + { + "id": "4205", + "type": "gene", + "text": "The degree of hypoperfusion was slightly related to decrease in FEV1 . 0 % , V25 and PaO2 and increase in circulating blood volume and peripheral red blood cell counts .", + "entities": [] + }, + { + "id": "4206", + "type": "gene", + "text": "Angionephroscintigraphy in the diagnosis of diseases of the kidney", + "entities": [] + }, + { + "id": "4207", + "type": "gene", + "text": "The TCF - 1 alpha binding site was also required for TCR alpha enhancer activity in transcriptionally active extracts from Jurkat but not HeLa cells , confirming that TCF - 1 alpha is a T - cell - specific transcription factor .", + "entities": [ + "TCF - 1 alpha binding site", + "TCR alpha enhancer", + "TCF - 1 alpha", + "T - cell - specific transcription factor" + ] + }, + { + "id": "4208", + "type": "gene", + "text": "Serum and peritoneal dialysis fluid ( PDF ) were collected for assay throughout the course of the study and for 5 days thereafter .", + "entities": [] + }, + { + "id": "4209", + "type": "gene", + "text": "[ figure : see text ] The Stille coupling reaction has been performed in 1 - butyl - 3 - methylimidazolium tetrafluoroborate ( BMIM BF4 ) , a room - temperature ionic liquid ( RTIL ) .", + "entities": [] + }, + { + "id": "4210", + "type": "gene", + "text": "SIP1 ( Smad interacting protein 1 ) and deltaEF1 ( delta - crystallin enhancer binding factor ) are structurally similar transcriptional repressors .", + "entities": [ + "SIP1", + "Smad interacting protein 1", + "deltaEF1", + "delta - crystallin enhancer binding factor" + ] + }, + { + "id": "4211", + "type": "gene", + "text": "We also studied a new parameter : the angle to maximal peak torque ( APT ) .", + "entities": [] + }, + { + "id": "4212", + "type": "gene", + "text": "A 36 - kDa protein that was localized to the membrane fraction was detected in minicells containing plasmids with the ftsN gene , confirming that FtsN was a membrane protein .", + "entities": [ + "ftsN gene", + "FtsN" + ] + }, + { + "id": "4213", + "type": "gene", + "text": "Over - expression of Azf1p in the yeast cell does not influence the expression level of the mitochondrial transcription factor Mtf1p , indicating that the influence of Azf1p on the suppression of the special mitochondrial RNA polymerase mutant is an indirect one .", + "entities": [ + "Azf1p", + "mitochondrial transcription factor Mtf1p", + "Azf1p", + "mitochondrial RNA polymerase mutant" + ] + }, + { + "id": "4214", + "type": "gene", + "text": "The activity of the transcription factor CREB is regulated by extracellular stimuli that result in its phosphorylation at a critical serine residue , Ser133 .", + "entities": [ + "transcription factor CREB" + ] + }, + { + "id": "4215", + "type": "gene", + "text": "Oligonucleotide - directed mutagenesis was used to create an NdeI restriction site at the natural ATG of the yeast R .", + "entities": [ + "NdeI restriction site" + ] + }, + { + "id": "4216", + "type": "gene", + "text": "To understand further the expression and regulation of the V1aR , we now describe the genomic characteristics , tissue expression , chromosomal localization , and regional mapping of the human V1aR gene , AVPR1A .", + "entities": [ + "V1aR", + "human V1aR gene", + "AVPR1A" + ] + }, + { + "id": "4217", + "type": "gene", + "text": "Paxillin acts as an adaptor molecule in integrin signaling .", + "entities": [ + "Paxillin", + "integrin" + ] + }, + { + "id": "4218", + "type": "gene", + "text": "Thus , hypoxia - inducible nuclear import and transactivation by recruitment of CBP can be functionally separated from one another and play critical roles in signal transduction by HIF - 1alpha .", + "entities": [ + "CBP", + "HIF - 1alpha" + ] + }, + { + "id": "4219", + "type": "gene", + "text": "Catalytic activation of mitogen - activated protein ( MAP ) kinase phosphatase - 1 by binding to p38 MAP kinase : critical role of the p38 C - terminal domain in its negative regulation .", + "entities": [ + "mitogen - activated protein ( MAP ) kinase phosphatase - 1", + "p38 MAP kinase", + "p38 C - terminal domain" + ] + }, + { + "id": "4220", + "type": "gene", + "text": "While this Saccharomyces cerevisiae SIN4 gene product is a component of a mediator complex associated with RNA polymerase II , various studies suggest the involvement of Sin4 in the alteration of higher - order chromatin structure .", + "entities": [ + "SIN4 gene product", + "RNA polymerase II", + "Sin4" + ] + }, + { + "id": "4221", + "type": "gene", + "text": "3 ' RNA boundary experiments indicate that the 5 ' structure reduces the number of ( G / U ) AG repeats required for stable TRAP - trp leader RNA association .", + "entities": [ + "TRAP", + "trp" + ] + }, + { + "id": "4222", + "type": "gene", + "text": "In this study , we investigated STAT activation in a panel of rodent fibroblast cell lines stably transformed by diverse viral oncoproteins .", + "entities": [ + "STAT" + ] + }, + { + "id": "4223", + "type": "gene", + "text": "Electrical activity was evaluated by monitoring the general electrocorticogram ( ECoG ) as well as local DC steady potential ( two sites ) .", + "entities": [] + }, + { + "id": "4224", + "type": "gene", + "text": "Further studies in T - 24 cells demonstrated that HA fragments also induced I kappa B alpha phosphorylation and degradation , kappa B - linked reporter gene expression , and ICAM - 1 promoter activity in an NF - kappa B - dependent manner .", + "entities": [ + "I kappa B alpha", + "kappa B - linked reporter gene", + "ICAM - 1 promoter", + "NF - kappa B" + ] + }, + { + "id": "4225", + "type": "gene", + "text": "Groups dicker for price breaks as anesthetic gas goes multi - source .", + "entities": [] + }, + { + "id": "4226", + "type": "gene", + "text": "We report here that microinjection of an anti - CBP antiserum into fibroblasts can inhibit transcription from a cAMP responsive promoter .", + "entities": [ + "anti - CBP antiserum" + ] + }, + { + "id": "4227", + "type": "gene", + "text": "This utilization of an intronic polyadenylation site without alternative exon usage is comparable to the mechanism whereby both secreted and membrane - bound forms of the immunoglobulin mu heavy chain are made from a single genetic locus .", + "entities": [ + "immunoglobulin mu heavy chain" + ] + }, + { + "id": "4228", + "type": "gene", + "text": "Vbeta segments are appended to DJbeta rearrangements , with little or no direct Vbeta to Jbeta joining , despite 12 / 23 compatibility of Vbeta 23 - RSSs and Jbeta12 - RSSs .", + "entities": [ + "Vbeta", + "DJbeta", + "Vbeta", + "Jbeta", + "Vbeta 23 - RSSs", + "Jbeta12 - RSSs" + ] + }, + { + "id": "4229", + "type": "gene", + "text": "The pattern for catalytic zinc sites included two ligands close in sequence , a sequence - distant ligand , and a main - chain hydrogen bond joining two ligands .", + "entities": [] + }, + { + "id": "4230", + "type": "gene", + "text": "French , M .", + "entities": [] + }, + { + "id": "4231", + "type": "gene", + "text": "The structure of the enhancer was also probed by inserting a pair of complementary synthetic oligodeoxynucleotides which represented the region between nt positions - 235 and - 215 into a truncated template which lacked the enhancer .", + "entities": [] + }, + { + "id": "4232", + "type": "gene", + "text": "In a series of 16 full - scale fire tests , investigators at the IIT Research Institute have concluded that automatic door control in the room of fire origin can significantly reduce the spread of toxic smoke and gases .", + "entities": [] + }, + { + "id": "4233", + "type": "gene", + "text": "Retroviral replication requires that a portion of the primary transcripts generated from proviral DNA be spliced to serve as mRNA for the envelope protein and in Rous sarcoma virus as src mRNA .", + "entities": [ + "envelope protein", + "src mRNA" + ] + }, + { + "id": "4234", + "type": "gene", + "text": "As in S . cerevisiae , the sequence of rhp51 + showed two MluI cell - cycle boxes and a putative DNA damage - responsive element in its upstream region .", + "entities": [ + "rhp51 +", + "MluI cell - cycle boxes" + ] + }, + { + "id": "4235", + "type": "gene", + "text": "16 , 99 - 104 ) .", + "entities": [] + }, + { + "id": "4236", + "type": "gene", + "text": "The role of saliva in sour taste perception was investigated in a series of 4 experiments .", + "entities": [] + }, + { + "id": "4237", + "type": "gene", + "text": "Recent literature has suggested that beta - 2 transferrin can also be used as a clinical marker for perilymph .", + "entities": [ + "beta - 2 transferrin" + ] + }, + { + "id": "4238", + "type": "gene", + "text": "Next , we stably overexpressed wild - type Shc or Y317F mutant Shc into HIRc cells .", + "entities": [ + "wild - type Shc", + "Y317F mutant Shc" + ] + }, + { + "id": "4239", + "type": "gene", + "text": "Continued development of the rat conditioning paradigm is especially warranted because of the ability to record sympathetic nerve activity in intact , awake subjects and the large number of readily available genetic strains , which model human pathological states .", + "entities": [] + }, + { + "id": "4240", + "type": "gene", + "text": "His HC II activity and antigen levels were 49 % and 50 % , respectively , and his daughter also showed similar low levels .", + "entities": [ + "HC II" + ] + }, + { + "id": "4241", + "type": "gene", + "text": "BACKGROUND : The Bazett - corrected QT ( QTc ) interval during exercise has been used as a marker for ischemic disease , arrhythmogenic substrate and the long QT syndrome .", + "entities": [] + }, + { + "id": "4242", + "type": "gene", + "text": "PDGF A - chain levels increase in cultured vascular smooth muscle cells ( SMCs ) exposed to ATII .", + "entities": [ + "PDGF A - chain", + "ATII" + ] + }, + { + "id": "4243", + "type": "gene", + "text": "Similarly , actuarial interpretations for the second protocols were not more frequently selected by therapists as more valid , regardless of treatment condition and elevation of the F and F - K indices on the first MMPI profile .", + "entities": [] + }, + { + "id": "4244", + "type": "gene", + "text": "Studies are necessary to assess the source of contamination and potential role of MRSA - contaminated milk in the transmission of MRSA to neonates .", + "entities": [] + }, + { + "id": "4245", + "type": "gene", + "text": "However , the ratio M / Pc provides a useful index that seems to be independent of the metabolic demand .", + "entities": [] + }, + { + "id": "4246", + "type": "gene", + "text": "Short - course amphotericin B therapy for candidemia in pediatric patients .", + "entities": [] + }, + { + "id": "4247", + "type": "gene", + "text": "An important mechanism by which the tumor suppressor p53 maintains genomic stability is to induce cell cycle arrest through activation of the cyclin - dependent kinase inhibitor p21 ( WAF1 / Cip1 ) gene .", + "entities": [ + "p53", + "cyclin - dependent kinase", + "p21", + "WAF1", + "Cip1" + ] + }, + { + "id": "4248", + "type": "gene", + "text": "SKP1 - SnRK protein kinase interactions mediate proteasomal binding of a plant SCF ubiquitin ligase .", + "entities": [ + "SKP1", + "SnRK", + "SCF ubiquitin ligase" + ] + }, + { + "id": "4249", + "type": "gene", + "text": "It contains three putative binding sites for transcription factor Sp1 as well as several short sequences that are similar to known cis - acting enhancers or binding sites for transcription factors .", + "entities": [ + "transcription factor Sp1" + ] + }, + { + "id": "4250", + "type": "gene", + "text": "Its role in these processes suggests that the function of c - Myb may be important early in the establishment of the hematopoietic lineage .", + "entities": [ + "c - Myb" + ] + }, + { + "id": "4251", + "type": "gene", + "text": "To understand the molecular regulation of these genes in thyroid cells , the effect of thyroid transcription factor 1 ( TTF - 1 ) and the paired domain - containing protein 8 ( Pax - 8 ) on the transcriptional activity of the deiodinase promoters were studied .", + "entities": [ + "thyroid transcription factor 1", + "TTF - 1", + "paired domain - containing protein 8", + "Pax - 8", + "deiodinase promoters" + ] + }, + { + "id": "4252", + "type": "gene", + "text": "The observation that beta 2m with covalently attached peptide can effectively create CTL target structures in vitro offers new possibilities for the in vivo induction of epitope - specific CTL responses by either DNA immunization or injection of the purified epitope - linked beta 2m .", + "entities": [ + "beta 2m", + "beta 2m" + ] + }, + { + "id": "4253", + "type": "gene", + "text": "Activation of ERK1 / 2 is correlated with induction of the immediate - early response genes .", + "entities": [ + "ERK1 / 2", + "immediate - early response genes" + ] + }, + { + "id": "4254", + "type": "gene", + "text": "The 1 . 9 - kb C mu RNA contains the 3 ' sequence characteristic of secreted mu chain , whereas the longer species bear that of membrane - bound mu chin .", + "entities": [ + "C mu", + "mu chain", + "mu" + ] + }, + { + "id": "4255", + "type": "gene", + "text": "These patients failed to respond to intravenous cyclophosphamide and steroids and were then changed to receive oral cyclosporine A , at a dose of 5 mg / kg / day .", + "entities": [] + }, + { + "id": "4256", + "type": "gene", + "text": "The background processes depending on the etiological factor and the character of lesion of the epithelium are divided into dyshormonal , inflammatory , and posttraumatic .", + "entities": [] + }, + { + "id": "4257", + "type": "gene", + "text": "The active state is terminated by hydrolysis of bound GTP , producing inactive ARF - GDP .", + "entities": [ + "ARF - GDP" + ] + }, + { + "id": "4258", + "type": "gene", + "text": "Elimination of ETH1 in apn1 strains also increased spontaneous mutation rates 9 - or 31 - fold compared to the wild type as determined by reversion to adenine or lysine prototrophy , respectively .", + "entities": [ + "ETH1", + "apn1" + ] + }, + { + "id": "4259", + "type": "gene", + "text": "After the meal containing potato , plasma glucose levels rose sharply , peaked at 30 - 45 min and fell below initial levels 2 to 3 h later .", + "entities": [] + }, + { + "id": "4260", + "type": "gene", + "text": "Automatic view box .", + "entities": [] + }, + { + "id": "4261", + "type": "gene", + "text": "In experiment 2 the rats had free access to two bottles , one of which contained tap water , and the other contained either an ethanol ( 6 % ) or a sucrose ( 5 % ) solution .", + "entities": [] + }, + { + "id": "4262", + "type": "gene", + "text": "Their biosynthesis proceeds via linear precursors that become branched by beta1 , 6 - GlcNAc transferases ( IGnT6 , GlcNAc to Gal ) .", + "entities": [ + "beta1 , 6 - GlcNAc transferases" + ] + }, + { + "id": "4263", + "type": "gene", + "text": "The pentafluorobenzyl derivative of clonidine yields an intense ion fragment at m / z 354 , and the lower limit of detection is 0 . 025 ng / ml for a 1 - ml plasma sample .", + "entities": [] + }, + { + "id": "4264", + "type": "gene", + "text": "Modulation of human heat shock factor trimerization by the linker domain .", + "entities": [ + "human heat shock factor" + ] + }, + { + "id": "4265", + "type": "gene", + "text": "Although it has been shown that it is possible to use orally administered testosterone to maintain se - T levels in the normal male range , the convenience to the patient must be balanced against the cost and possible side effects of the large doses required .", + "entities": [] + }, + { + "id": "4266", + "type": "gene", + "text": "The variable HMG dosage regimen was found to offer no advantages when compared with our standard daily dosage regimen .", + "entities": [ + "HMG" + ] + }, + { + "id": "4267", + "type": "gene", + "text": "The p20 - CGGBP gene is conserved among mammals but shows no homology to non - vertebrate species .", + "entities": [ + "p20 - CGGBP gene" + ] + }, + { + "id": "4268", + "type": "gene", + "text": "Promoter transcriptional activity was determined for a wide 5 ' portion of the human annexin A5 gene , from bp - 1275 to + 79 relative to the most 5 ' of several discrete transcription start points .", + "entities": [ + "annexin A5 gene" + ] + }, + { + "id": "4269", + "type": "gene", + "text": "Both TRE - like elements were capable of binding AP1 .", + "entities": [ + "AP1" + ] + }, + { + "id": "4270", + "type": "gene", + "text": "Degradation of the soybean ribulose - 1 , 5 - bisphosphate carboxylase small - subunit mRNA , SRS4 , initiates with endonucleolytic cleavage .", + "entities": [ + "soybean ribulose - 1 , 5 - bisphosphate carboxylase small - subunit mRNA", + "SRS4" + ] + }, + { + "id": "4271", + "type": "gene", + "text": "A DNA motif related to the cAMP - responsive element and an exon - located activator protein - 2 binding site in the human tissue - type plasminogen activator gene promoter cooperate in basal expression and convey activation by phorbol ester and cAMP .", + "entities": [ + "exon - located activator protein - 2 binding site", + "human tissue - type plasminogen activator gene promoter" + ] + }, + { + "id": "4272", + "type": "gene", + "text": "The percentage RFR reduction at the end of CPB showed significant correlation with 1 ) CPB duration ( r = 0 . 49 ) , 2 ) oxygen flow rate index ( OFRI ) , i . e . flow / min in the bubble oxygenator / m2 bsa ( r = 0 . 38 ) , and 3 ) blood flow rate index ( BFRI ) , i . e . average volume of blood pumped through the heart - lung machine / min CPB time / m2 bsa ( r = 0 . 51 ) .", + "entities": [] + }, + { + "id": "4273", + "type": "gene", + "text": "Cell survival by Epo did not require activation of other known signaling pathways including PI - 3 kinase , PLC - gamma , Ras or Stats .", + "entities": [ + "Epo", + "PI - 3 kinase", + "PLC - gamma", + "Ras", + "Stats" + ] + }, + { + "id": "4274", + "type": "gene", + "text": "Identity elements in tRNA for mono - and dimethylation reactions by the recombinant pfTrm1p were identified using in vitro T7 transcripts of 33 variants of tRNA ( Asp ) and tRNA ( Phe ) from yeast .", + "entities": [ + "recombinant pfTrm1p", + "tRNA ( Asp )", + "tRNA ( Phe )" + ] + }, + { + "id": "4275", + "type": "gene", + "text": "Issues of distribution of kinetic energy of traumatizing object in direct contact interaction with head during impact are discussed from position of biomechanics .", + "entities": [] + }, + { + "id": "4276", + "type": "gene", + "text": "Reciprocally , HMGI - C expression also coordinately enhances PIAS3 - mediated repression of STAT3 - dependent transactivation .", + "entities": [ + "HMGI - C", + "PIAS3", + "STAT3" + ] + }, + { + "id": "4277", + "type": "gene", + "text": "In the control group , platelet markers increased 1 h after surgery .", + "entities": [] + }, + { + "id": "4278", + "type": "gene", + "text": "Although % BF was correlated with all the BMIs ( r = 0 . 60 - 0 . 82 ) , applying objective definitions of obesity based on BMIs or % BF by densitometry often produced conflicting results .", + "entities": [] + }, + { + "id": "4279", + "type": "gene", + "text": "These case reports provide further evidence that LiCO3 can be a useful medication in the treatment of aggressive behavior and affective instability after brain injury , but that it has significant potential for neurotoxicity in this population , particularly when used in conjunction with neuroleptic agents .", + "entities": [] + }, + { + "id": "4280", + "type": "gene", + "text": "The mouse platelet - derived growth factor ( PDGF ) beta - receptor promoter contains a CCAAT motif , and NF - Y plays an essential role in its transcription .", + "entities": [ + "mouse platelet - derived growth factor ( PDGF ) beta - receptor promoter", + "NF - Y" + ] + }, + { + "id": "4281", + "type": "gene", + "text": "Other parameters of iron metabolism , including ferritin , were not found to contribute to the risk .", + "entities": [ + "ferritin" + ] + }, + { + "id": "4282", + "type": "gene", + "text": "Enhancement of the immune response by aspecific action of vaccine additives in the aerogenic immunization of swine against swine plague", + "entities": [] + }, + { + "id": "4283", + "type": "gene", + "text": "The lysozyme FEF site is immediately 5 ' to a PU .", + "entities": [ + "FEF", + "PU" + ] + }, + { + "id": "4284", + "type": "gene", + "text": "Scotchbond 2 showed the least dye penetration but not statistically less than the XR bond / Silus Plus combination .", + "entities": [] + }, + { + "id": "4285", + "type": "gene", + "text": "Successful treatment of candidiasis with transfer factor .", + "entities": [ + "transfer factor" + ] + }, + { + "id": "4286", + "type": "gene", + "text": "Adult Amblyomma lepidum ticks fed as nymphs on this goat transmitted heartwater to a Friesian ( Bos taurus ) calf .", + "entities": [] + }, + { + "id": "4287", + "type": "gene", + "text": "Molecular cloning and expression of RPE65 , a novel retinal pigment epithelium - specific microsomal protein that is post - transcriptionally regulated in vitro .", + "entities": [ + "RPE65" + ] + }, + { + "id": "4288", + "type": "gene", + "text": "Like the consensus mammalian LHbeta gene , the 5 ' - flanking region of the gpLH / CGbeta gene contains a single TATA sequence 37 bp upstream of the translation start codon .", + "entities": [ + "consensus mammalian LHbeta gene", + "gpLH", + "CGbeta" + ] + }, + { + "id": "4289", + "type": "gene", + "text": "The method also eliminates tagging of venous spins and concern about asymmetric magnetization transfer effects .", + "entities": [] + }, + { + "id": "4290", + "type": "gene", + "text": "Preservatives are an important component of ophthalmic preparations , providing antimicrobial activity in the bottle and preventing decomposition of active drug .", + "entities": [] + }, + { + "id": "4291", + "type": "gene", + "text": "Genetic experiments using mutants defective in apontic and bruno reveal a functional interaction between these genes .", + "entities": [ + "apontic", + "bruno" + ] + }, + { + "id": "4292", + "type": "gene", + "text": "This effect required ( i ) IR activation since it was abrogated by IR mutation at tyrosines 1162 and 1163 and ( ii ) NF - kappaB activation since it was abolished by overexpression of dominant - negative IkappaB - alpha ( A32 / 36 ) and mimicked by overexpression of the NF - kappaB c - Rel subunit .", + "entities": [ + "IR", + "IR", + "NF - kappaB", + "dominant - negative IkappaB - alpha ( A32 / 36 )", + "c - Rel subunit" + ] + }, + { + "id": "4293", + "type": "gene", + "text": "A study of human genes coding for U4 small nuclear RNA is presented .", + "entities": [ + "U4 small nuclear RNA" + ] + }, + { + "id": "4294", + "type": "gene", + "text": "The inner ears were exposed by microdissection , and the vestibular sensory regions were either sectioned and studied with light or electron microscopy , or prepared and studied with the surface specimen technique .", + "entities": [] + }, + { + "id": "4295", + "type": "gene", + "text": "After 6 h of reperfusion , PO2 / FlO2 ratio was significantly better after Combined Therapy ( 372 + / - 52 mm Hg ) than in the Recipient Instilled ( 117 + / - 47 mm Hg ) and Control groups ( 87 + / - 26 mm Hg ) , with intermediate values in Donor Aerosol dogs ( 232 + / - 64 mm Hg ) .", + "entities": [] + }, + { + "id": "4296", + "type": "gene", + "text": "Nearly all isolates of S . intermedius and most isolates of S . constellatus , but only 19 % of those of S . anginosus , were associated with abscess .", + "entities": [] + }, + { + "id": "4297", + "type": "gene", + "text": "The relative importance of these two mechanisms differed in a response element - specific manner .", + "entities": [] + }, + { + "id": "4298", + "type": "gene", + "text": "Effects of nitrogen ( PN2 : 5 and 14 MPa ) and helium ( PHe : 13 and 14 MPa ) were also tested .", + "entities": [] + }, + { + "id": "4299", + "type": "gene", + "text": "Histological evaluation revealed a more than twofold increase in the number of interepithelial mononuclear cells ( p less than 0 . 005 ) , while the number of epithelial cells / 100 microns of villous mucosa and the mean height of the epithelial cells were comparable in both groups .", + "entities": [] + }, + { + "id": "4300", + "type": "gene", + "text": "These results indicate that ATF4 regulates basal and CdCl ( 2 ) - induced expression of the ho - 1 gene in a cell - specific manner and possibly in a complex with Nrf2 .", + "entities": [ + "ATF4", + "ho - 1 gene", + "Nrf2" + ] + }, + { + "id": "4301", + "type": "gene", + "text": "HVH2 mRNA showed an expression pattern distinct from CL100 ( human homologue of mouse MKP1 ) and PAC1 , two previously identified MAP kinase phosphatases .", + "entities": [ + "HVH2 mRNA", + "CL100", + "human homologue of mouse MKP1", + "PAC1", + "MAP kinase phosphatases" + ] + }, + { + "id": "4302", + "type": "gene", + "text": "We report here the cloning of the human goosecoid gene ( GSC ) from a genomic library and the sequence of its encoded protein .", + "entities": [ + "human goosecoid gene", + "GSC" + ] + }, + { + "id": "4303", + "type": "gene", + "text": "( 2 ) The inappropriateness of adaptive segmentation for the isolation of spikes and sharp waves , which had been anticipated in view of the short duration of such transients in relation to the length of the window ( 1 . 2 sec ) used for the autocorrelation functions employed in the segmentation algorithm , was confirmed .", + "entities": [] + }, + { + "id": "4304", + "type": "gene", + "text": "Nhp2p is a highly basic protein that belongs to a family of putative RNA - binding proteins .", + "entities": [ + "Nhp2p" + ] + }, + { + "id": "4305", + "type": "gene", + "text": "New diagnostic strategies for lupus anticoagulants and antiphospholipid antibodies .", + "entities": [] + }, + { + "id": "4306", + "type": "gene", + "text": "The PDGFR mutants that failed to associate with PLC gamma were not able to mediate the PDGF - dependent production of inositol phosphates .", + "entities": [ + "PDGFR mutants", + "PLC gamma", + "PDGF" + ] + }, + { + "id": "4307", + "type": "gene", + "text": "In addition , we have isolated a genomic fragment containing the most distal 5 ' sequences of the major GGT mRNA in HepG2 cells .", + "entities": [ + "GGT mRNA" + ] + }, + { + "id": "4308", + "type": "gene", + "text": "C . D2 - Chr 4 congenic strains harboring DBA / 2 alleles associated with the Pctr1 locus contained DBA / 2 \" resistant \" alleles of the CDK4 / CDK6 inhibitors p16 and p15 .", + "entities": [ + "Pctr1 locus", + "CDK4", + "CDK6", + "p16", + "p15" + ] + }, + { + "id": "4309", + "type": "gene", + "text": "The ability of SMRT to associate with these transcription factors and thereby to mediate repression is strongly inhibited by activation of tyrosine kinase signaling pathways , such as that represented by the epidermal growth factor receptor .", + "entities": [ + "SMRT", + "tyrosine kinase", + "epidermal growth factor receptor" + ] + }, + { + "id": "4310", + "type": "gene", + "text": "We found strand selective repair in DNA fragments within two active genes , DHFR and an unknown gene adjacent to DHFR .", + "entities": [ + "DHFR", + "DHFR" + ] + }, + { + "id": "4311", + "type": "gene", + "text": "Significant treatment - related problems appeared during the second decade in 5 patients , including one chest wall sarcoma ; all of these patients had received at least 60 Gy to breast and regional nodal areas .", + "entities": [] + }, + { + "id": "4312", + "type": "gene", + "text": "It is shown that , for any periodic input , the map representing the relation between input phases at consecutive discharge times can be restricted to a piecewise continuous , orientation preserving circle map .", + "entities": [] + }, + { + "id": "4313", + "type": "gene", + "text": "There were gene clusters encoding photosynthesis components such as the psbB - psbH - petB - petD and the psbE - psbF clusters .", + "entities": [ + "psbB", + "psbH", + "petB", + "petD" + ] + }, + { + "id": "4314", + "type": "gene", + "text": "This last includes tissue O2 transfer ( Ft ' ) and mitochondrial O2 utilization ( Fm ' ) .", + "entities": [] + }, + { + "id": "4315", + "type": "gene", + "text": "The maximum amplitude of evoked responses in the cervical sympathetic trunk was obtained when the T2 white ramus was stimulated and decreased gradually when followed by the stimulation of T1 , T3 , T4 and T5 white rami .", + "entities": [] + }, + { + "id": "4316", + "type": "gene", + "text": "The presence of PDZ and SAM domains in the KS5 protein suggests that it may act as a molecular adaptor , promoting and relaying information in a signal transduction pathway .", + "entities": [ + "PDZ", + "KS5 protein" + ] + }, + { + "id": "4317", + "type": "gene", + "text": "Phosphatidylinositol 3 - kinase potentiates , but does not trigger , T cell proliferation mediated by the IL - 2 receptor .", + "entities": [ + "Phosphatidylinositol 3 - kinase", + "IL - 2 receptor" + ] + }, + { + "id": "4318", + "type": "gene", + "text": "CPAP reduced isotime ( defined as the last common minute of exercise ) VO2 and dyspnea in those patients with more severe lung disease , but these values tended to increase slightly in the patients with only mild lung disease .", + "entities": [] + }, + { + "id": "4319", + "type": "gene", + "text": "Genoa , Italy , 24 - 28 August 1997 .", + "entities": [] + }, + { + "id": "4320", + "type": "gene", + "text": "The site - specific DNA inversion system Cin encoded by the bacteriophage P1 consists of a recombinase , two inverted crossing - over sites and a recombinational enhancer .", + "entities": [ + "Cin", + "recombinase" + ] + }, + { + "id": "4321", + "type": "gene", + "text": "MEF and AML1B synergistically transactivated an interleukin 3 promoter reporter gene construct , yet the activating activity of MEF was abolished when MEF was coexpressed with AML1 / ETO .", + "entities": [ + "MEF", + "AML1B", + "interleukin 3 promoter reporter gene construct", + "MEF", + "MEF", + "AML1", + "ETO" + ] + }, + { + "id": "4322", + "type": "gene", + "text": "Use of prostaglandin F2 alpha ( PGF2 alpha ) in cattle breeding .", + "entities": [] + }, + { + "id": "4323", + "type": "gene", + "text": "Band structure effects of transport properties in icosahedral quasicrystals .", + "entities": [] + }, + { + "id": "4324", + "type": "gene", + "text": "Accepting arbitrarily chosen limits of maximized errors of + / - 10 % , it could be shown that the system did not work acceptably when the mean carbon dioxide concentration was below 1 . 5 vol . % within the fresh gas flow rates ( 2 . 2 - - 7 . 7 1 min - 1 ) and the range of minute ventilation ( 4 - - 10 1 min - 1 ) employed .", + "entities": [] + }, + { + "id": "4325", + "type": "gene", + "text": "This suggests that the DcuS - DcuR system responds to external substrates .", + "entities": [ + "DcuS", + "DcuR" + ] + }, + { + "id": "4326", + "type": "gene", + "text": "Replacement variant histone genes contain intervening sequences .", + "entities": [ + "Replacement variant histone genes" + ] + }, + { + "id": "4327", + "type": "gene", + "text": "10 long - term hemodialysis patients had immediate and redistribution thallium - 201 myocardial imaging performed after a course of hemodialysis .", + "entities": [] + }, + { + "id": "4328", + "type": "gene", + "text": "This sequence is very similar to the insulin response sequence found in the regulatory region of other genes negatively regulated by insulin such as those encoding phosphoenolpyruvate carboxykinase , tyrosine aminotransferase , and insulin - like growth factor - binding protein 1 .", + "entities": [ + "insulin response sequence", + "insulin", + "phosphoenolpyruvate carboxykinase", + "tyrosine aminotransferase", + "insulin - like growth factor - binding protein 1" + ] + }, + { + "id": "4329", + "type": "gene", + "text": "These studies identify several of the signal - transduction events involved in the apoptosis of malignant B cells that transpire following ligation of CD20 by anti - CD20 antibodies in the presence of Fc - receptor - expressing cells or secondary goat anti - ( mouse Ig ) antibodies and which may contribute to the tumor regressions observed in mouse models and clinical trials .", + "entities": [ + "CD20", + "anti - CD20 antibodies", + "Fc - receptor", + "anti - ( mouse Ig ) antibodies" + ] + }, + { + "id": "4330", + "type": "gene", + "text": "The nifJ and nifH promoters of Klebsiella pneumoniae are divergently transcribed sigma 54 - dependent promoters that are positively activated by the NifA protein .", + "entities": [ + "nifJ", + "nifH promoters of Klebsiella pneumoniae", + "sigma 54 - dependent promoters", + "NifA protein" + ] + }, + { + "id": "4331", + "type": "gene", + "text": "The remaining 80 patients underwent recordings of ECG , beat - to - beat arterial oxygen saturation ( SaO2 ) , and respiration during both spontaneous and controlled breathing .", + "entities": [] + }, + { + "id": "4332", + "type": "gene", + "text": "Biochemical studies revealed the expected loss of ChAT activity in the dorsal and ventral hippocampi of lesioned animals along with elevated levels of norepinephrine ( NE ) in the dorsal hippocampus of MS / HSI animals . ( ABSTRACT TRUNCATED AT 250 WORDS )", + "entities": [ + "ChAT" + ] + }, + { + "id": "4333", + "type": "gene", + "text": "When blood samples of patients with hyperbilirubinemia were analyzed , direct measurement of ZPP by this fluorimeter yielded significantly higher levels than did an alternate extraction method .", + "entities": [] + }, + { + "id": "4334", + "type": "gene", + "text": "The data indicate a three - phase reaction after B1 injection : Phase 1 - - shortly after injection there is a drop of all parameters lasting for 30 sec .", + "entities": [] + }, + { + "id": "4335", + "type": "gene", + "text": "The distribution of red rice cultivation in Sri Lanka is coincident with the HIDD villages .", + "entities": [] + }, + { + "id": "4336", + "type": "gene", + "text": "The present study sought to develop an equation to estimate VO2peak in peripheral arterial occlusive disease ( PAOD ) patients with intermittent claudication and to determine independent predictors of VO2peak in this population .", + "entities": [] + }, + { + "id": "4337", + "type": "gene", + "text": "Northern and Western blot analyses demonstrated that Graf2 is expressed in several tissues , with the highest expression in skeletal muscle .", + "entities": [ + "Graf2" + ] + }, + { + "id": "4338", + "type": "gene", + "text": "Increasing mean arterial pressure by phenylephrine infusion to levels much greater than produced by NMA and NNA caused only small reductions in cardiac output .", + "entities": [] + }, + { + "id": "4339", + "type": "gene", + "text": "Near a third ( 31 . 6 % ) of Insulin Dependent and a third ( 33 . 41 % ) for Non Insulin Dependent were of D , F , H White ' s Class .", + "entities": [ + "Insulin", + "Insulin" + ] + }, + { + "id": "4340", + "type": "gene", + "text": "The fourth dose produced favorable results ( 66 . 7 % ) in individuals with HB antibodies between 10 and 100 IU / ml and unfavorable ones ( 3 . 8 % ) where the HB antibodies were below 10 IU / ml .", + "entities": [ + "HB antibodies", + "HB antibodies" + ] + }, + { + "id": "4341", + "type": "gene", + "text": "Commutative saccadic generator is sufficient to control a 3 - D ocular plant with pulleys .", + "entities": [] + }, + { + "id": "4342", + "type": "gene", + "text": "Two phosphopeptides , identified as RS - [ 32P ] SGASGLLTSEHHSR and S - [ 32P ] SGASGLLTSEHHSR , were obtained after stoichiometric phosphorylation and trypsinization of the peptide .", + "entities": [] + }, + { + "id": "4343", + "type": "gene", + "text": "Estrus and copulative abilities of androgen - sterilized rats", + "entities": [] + }, + { + "id": "4344", + "type": "gene", + "text": "Interestingly , although E domains of these two receptors are much less conserved , replacement of this domain in rtER by its human counterpart resulted in higher estradiol sensitivity but no increase in the magnitude of transactivation .", + "entities": [ + "rtER" + ] + }, + { + "id": "4345", + "type": "gene", + "text": "Based on these data , we conclude that transcription of prgX is initiated from the Qa promoter in prgQ , and PrgX autoregulates its transcription either by mediating transcriptional readthrough or increasing mRNA stability .", + "entities": [ + "prgX", + "Qa promoter", + "prgQ", + "PrgX" + ] + }, + { + "id": "4346", + "type": "gene", + "text": "Based on the occurrence of several transcription signals in the Thermus pyr promoter region and strong amino acid sequence identities ( about 60 % ) between Thermus PyrR and the PyrR attenuation proteins of two Bacillus sp . , we propose a regulatory mechanism involving transcriptional attenuation to control pyr gene expression in Thermus .", + "entities": [ + "Thermus pyr promoter region", + "Thermus PyrR", + "PyrR attenuation proteins", + "pyr gene" + ] + }, + { + "id": "4347", + "type": "gene", + "text": "Analysis of glucocorticoid unresponsive cell variants using a mouse glucocorticoid receptor complementary DNA clone .", + "entities": [ + "mouse glucocorticoid receptor" + ] + }, + { + "id": "4348", + "type": "gene", + "text": "The method involved deproteinizing samples with two volumes of acetonitrile followed by injection of 5 microliters of deproteinized supernatant onto a C18 reversed - phase column .", + "entities": [] + }, + { + "id": "4349", + "type": "gene", + "text": "At 43 % blood pressure reduction , PCO2 fell by 0 . 53 kPa , a decrease which could not explain the observed CBF fall of 27 % .", + "entities": [] + }, + { + "id": "4350", + "type": "gene", + "text": "Treatment with amphotericin B and flucytosine led to improvement of the symptoms but did not eradicate the micro - organisms from the cerebrospinal fluid ( CSF ) .", + "entities": [] + }, + { + "id": "4351", + "type": "gene", + "text": "In addition , we found that cell - specific suppression of RA - stimulated zif268 gene expression can be attributed to a 29 base pair nucleotide sequence , located downstream of the RA - responsive region in the zif268 gene .", + "entities": [ + "zif268 gene", + "zif268 gene" + ] + }, + { + "id": "4352", + "type": "gene", + "text": "These responses were compared with others in the same subjects under the same conditions and it was concluded that the antihypertensive effect of labetalol is explained by concurrent blockade of alpha - and beta - adrenoceptors .", + "entities": [ + "alpha - and beta - adrenoceptors" + ] + }, + { + "id": "4353", + "type": "gene", + "text": "A case of Goodpasture ' s syndrome .", + "entities": [] + }, + { + "id": "4354", + "type": "gene", + "text": "Based on a morphological study of the resin - dentine interface , a broad selection of dentine adhesive systems was classified following their adhesion - strategy .", + "entities": [] + }, + { + "id": "4355", + "type": "gene", + "text": "An economic analysis using West of Scotland Coronary Prevention Study ( WOSCOPS ) findings indicates that statin treatment would have prevented 318 events per 10 , 000 patients in a population similar to that in WOSCOPS ( average 1 . 5 % annual risk of a cardiovascular event ) at a discounted cost per life - year gained of 20 , 375 pounds ( $ 31 , 818 ) .", + "entities": [ + "statin" + ] + }, + { + "id": "4356", + "type": "gene", + "text": "Thromboplastin time , partial thromboplastin time , thrombin time , heat - dependent fibrin , clot retraction , and clotting factors II , V , VIII , IX , X , and the platelet count were determined .", + "entities": [ + "Thromboplastin", + "thromboplastin", + "thrombin", + "fibrin", + "clotting factors II , V , VIII , IX , X" + ] + }, + { + "id": "4357", + "type": "gene", + "text": "During the following pregnancy ultrasonographic studies of the male fetus in the 16th week of gestation revealed severe micrognathia , short and wide thumbs , and big toes , and bowed tibiae .", + "entities": [] + }, + { + "id": "4358", + "type": "gene", + "text": "This transition is regulated positively by G1 - specific cyclin - dependent kinases ( cdks ) and negatively by the product of the retinoblastoma tumour suppressor gene , pRb .", + "entities": [ + "G1 - specific cyclin - dependent kinases", + "cdks", + "retinoblastoma tumour suppressor gene", + "pRb" + ] + }, + { + "id": "4359", + "type": "gene", + "text": "A unique leucine - proline repeat element found N - terminal to the DNA - binding domain of EmBP - 1 does not appear to play a role in DNA - binding or dimerization .", + "entities": [ + "EmBP - 1" + ] + }, + { + "id": "4360", + "type": "gene", + "text": "Mechanism of immunogenesis in vaccination with streptomycin - dependent mutants of salmonellae and shigellae .", + "entities": [] + }, + { + "id": "4361", + "type": "gene", + "text": "We previously delineated a region in the fatty - acid synthase promoter , which was responsible for obesity - related overexpression of the fatty - acid synthase ( FAS ) gene , by negatively regulating the activity of the downstream promoter in lean but not obese rat fat cells .", + "entities": [ + "fatty - acid synthase promoter", + "fatty - acid synthase", + "FAS" + ] + }, + { + "id": "4362", + "type": "gene", + "text": "We have isolated and sequenced two overlapping cDNA fragments which could encode the complete amino acid sequence of rat testis fructose - 6 - phosphate , 2 - kinase : fructose - 2 , 6 - bisphosphatase .", + "entities": [ + "rat testis fructose - 6 - phosphate , 2 - kinase", + "fructose - 2 , 6 - bisphosphatase" + ] + }, + { + "id": "4363", + "type": "gene", + "text": "It was shown that administration of immunomodulator neurotropin ( NSP ) results in more steady consolidation and retention of feeding and avoidance behavior , and some neurophysiological mechanisms of that phenomena were revealed .", + "entities": [ + "neurotropin", + "NSP" + ] + }, + { + "id": "4364", + "type": "gene", + "text": "We also observed that cell surface CD4 ( - ) CD8 ( - ) CD3 ( - ) cells with rearranged TCR genes developed from Id3 - transduced but not from control - transduced pre - T cells in an FTOC .", + "entities": [ + "CD4", + "CD8", + "CD3", + "rearranged TCR genes", + "Id3" + ] + }, + { + "id": "4365", + "type": "gene", + "text": "In patients with osteomyelitis and joint empyema ( n = 48 ) PMN elastase had a sensitivity of 77 % , which was only exceeded by that of the unspecific erythrocyte sedimentation rate ( sensitivity 89 % ) .", + "entities": [ + "PMN elastase" + ] + }, + { + "id": "4366", + "type": "gene", + "text": "In the present study , we demonstrate that expression of TD - IkappaBalpha blocked phorbol myristate acetate - phytohemagglutinin or tumor necrosis factor alpha - induced IkappaBalpha gene transcription and abolished NF - kappaB DNA binding activity , due to the continued cytoplasmic sequestration of RelA ( p65 ) by TD - IkappaBalpha .", + "entities": [ + "TD - IkappaBalpha", + "acetate - phytohemagglutinin", + "tumor necrosis factor alpha", + "IkappaBalpha gene", + "NF - kappaB", + "RelA", + "p65", + "TD - IkappaBalpha" + ] + }, + { + "id": "4367", + "type": "gene", + "text": "There was no significant difference in developmental scores at 9 or 18 months , although PDF infants had a 2 . 8 ( - 1 . 3 - 6 . 8 ) point advantage in Bayley motor score scales .", + "entities": [] + }, + { + "id": "4368", + "type": "gene", + "text": "The dual specificity kinases mitogen - activated protein kinase ( MAPK ) kinase ( MKK ) 7 and MKK4 are the only molecules known to directly activate the stress kinases stress - activated protein kinases ( SAPKs ) / c - Jun N - terminal kinases ( JNKs ) in response to environmental or mitogenic stimuli .", + "entities": [ + "mitogen - activated protein kinase ( MAPK ) kinase ( MKK ) 7", + "MKK4", + "stress - activated protein kinases", + "SAPKs", + "c - Jun N - terminal kinases", + "JNKs" + ] + }, + { + "id": "4369", + "type": "gene", + "text": "We recommend that ovarian stimulation is done only if there is a valid indication after proper assessment of the ovaries , and that women who have had ovarian stimulation are followed for longer than at present .", + "entities": [] + }, + { + "id": "4370", + "type": "gene", + "text": "The small monomeric GTP - binding proteins of the RAB subfamily are key regulatory elements of the machinery that controls membrane traffic in eukaryotic cells .", + "entities": [ + "small monomeric GTP - binding proteins", + "RAB subfamily" + ] + }, + { + "id": "4371", + "type": "gene", + "text": "Antivitamin K agents", + "entities": [] + }, + { + "id": "4372", + "type": "gene", + "text": "Electrocardiograms of the month .", + "entities": [] + }, + { + "id": "4373", + "type": "gene", + "text": "Supplementation was stopped when pl - ALB reached 2 . 0 g / dL .", + "entities": [ + "pl - ALB" + ] + }, + { + "id": "4374", + "type": "gene", + "text": "Adapromine was established to evoke a decrease of the amplitude of the dominant peak and dominant theta - activity in power spectra of the EEG in the cortex and hippocamp , with an increase of rapid wave activity in the beta 2 range in the right cortex and hippocamp .", + "entities": [] + }, + { + "id": "4375", + "type": "gene", + "text": "The negative predictive value is 92 % , vs 80 % for the NCEP I .", + "entities": [] + }, + { + "id": "4376", + "type": "gene", + "text": "The Italian Lung Cancer Task Force ( FONICAP ) .", + "entities": [] + }, + { + "id": "4377", + "type": "gene", + "text": "METHODS : Experiments testing the new catheter and comparing it to the existing catheter included : ( 1 ) measurement of the laser output beam sizes and divergences ; ( 2 ) evaluation of particulate matter generation during ablation of atherosclerotic tissue ; ( 3 ) measurement of ablation hole sizes and tissue penetration rates ; ( 4 ) histopathologic examination of laser - induced in vivo vessel wall injury .", + "entities": [] + }, + { + "id": "4378", + "type": "gene", + "text": "This study was designed to assess and compare the ability of three different forms of DSG to block EIB .", + "entities": [] + }, + { + "id": "4379", + "type": "gene", + "text": "T1 - weighted MRI on the 49th postoperative day demonstrated bilateral and symmetrical hyperintense lesions in the globus pallidus .", + "entities": [] + }, + { + "id": "4380", + "type": "gene", + "text": "In group III , patients also received their own mediastinal drainage blood , shed for 6 hours after operation , after concentration and washing in a MBRS .", + "entities": [] + }, + { + "id": "4381", + "type": "gene", + "text": "Allelic variation in HLA - B and HLA - C sequences and the evolution of the HLA - B alleles .", + "entities": [ + "HLA - B", + "HLA - C sequences", + "HLA - B alleles" + ] + }, + { + "id": "4382", + "type": "gene", + "text": "Electrocardiographic QRS complexes and vectorcardiographic QRS loop", + "entities": [] + }, + { + "id": "4383", + "type": "gene", + "text": "We further show that proteolytic targeting by calpain II and the proteasome involves different structural elements of YY1 .", + "entities": [ + "calpain II", + "YY1" + ] + }, + { + "id": "4384", + "type": "gene", + "text": "SAPK / JNK activation was completely abolished in the absence of MKK7 , even though expression of MKK4 was strongly upregulated in mkk7 ( - / - ) mast cell lines , and phosphorylation of MKK4 occurred normally in response to multiple stress stimuli .", + "entities": [ + "SAPK", + "JNK", + "MKK7", + "MKK4", + "mkk7 ( - / - )", + "MKK4" + ] + }, + { + "id": "4385", + "type": "gene", + "text": "The mean minimum steady - state concentration after the oral regimen ( 23 micrograms . l - 1 ) was 78 % of that after the intramuscular regime ( 29 micrograms . l - 1 ) .", + "entities": [] + }, + { + "id": "4386", + "type": "gene", + "text": "Low PbrO2 readings , however , could be caused by local microhemorrhages , undetectable on CT or MRI .", + "entities": [] + }, + { + "id": "4387", + "type": "gene", + "text": "The protein encoded is 114 kDa and contains eight zinc finger motifs , seven of which are present in two clusters at opposite ends of the molecule .", + "entities": [] + }, + { + "id": "4388", + "type": "gene", + "text": "The expression of the first two genes located in this unit ( c - gvpD and c - gvpE ) was also monitored by Western blot ( immunoblot ) analyses using antisera raised against these proteins synthesized in Escherichia coli .", + "entities": [ + "c - gvpD", + "c - gvpE" + ] + }, + { + "id": "4389", + "type": "gene", + "text": "Interaction of Ets - 1 and the POU - homeodomain protein GHF - 1 / Pit - 1 reconstitutes pituitary - specific gene expression .", + "entities": [ + "Ets - 1", + "GHF - 1", + "Pit - 1" + ] + }, + { + "id": "4390", + "type": "gene", + "text": "Montelukast reduces airway eosinophilic inflammation in asthma : a randomized , controlled trial .", + "entities": [] + }, + { + "id": "4391", + "type": "gene", + "text": "Vitrectomy was still a significant risk factor when macular holes were excluded .", + "entities": [] + }, + { + "id": "4392", + "type": "gene", + "text": "Significant intergroup differences are highlighted for both selected dentoskeletal and soft tissue profile variables .", + "entities": [] + }, + { + "id": "4393", + "type": "gene", + "text": "Identification of the region in actin - binding protein that binds to the cytoplasmic domain of glycoprotein IBalpha .", + "entities": [ + "actin - binding protein", + "glycoprotein IBalpha" + ] + }, + { + "id": "4394", + "type": "gene", + "text": "The terminator region supported termination of transcripts initiated by RNA polymerase I in vivo .", + "entities": [ + "RNA polymerase I" + ] + }, + { + "id": "4395", + "type": "gene", + "text": "Although upstream regulators of Tec family kinases are relatively well characterized , little is known of the downstream effectors of these enzymes .", + "entities": [ + "Tec family kinases" + ] + }, + { + "id": "4396", + "type": "gene", + "text": "In terms of sequence repetitions , seven tandemly repeated copies of the hexanucleotide ATTGTT and three flanking regions of dyad symmetry were detected , all in ORF T3C .", + "entities": [] + }, + { + "id": "4397", + "type": "gene", + "text": "The usefulness of the lambda PG15 and the lambda AD5 cloning vectors was demonstrated by constructing large Neurospora crassa cDNA libraries .", + "entities": [] + }, + { + "id": "4398", + "type": "gene", + "text": "As a sequence - specific DNA binding transcription factor , p53 specifically binds to a 20 - bp consensus motif 5 ' - PuPuPuC ( A / T ) ( T / A ) GPyPyPyPuPuPuC ( A / T ) ( T / A ) GPyPyPy - 3 ' .", + "entities": [ + "p53" + ] + }, + { + "id": "4399", + "type": "gene", + "text": "A database search has revealed as the most significative homology a match with the human mitochondrial transcription termination factor ( mTERF ) , a protein that also binds DNA as a monomer and contains three leucine zippers forming intramolecular interactions .", + "entities": [ + "human mitochondrial transcription termination factor", + "mTERF" + ] + }, + { + "id": "4400", + "type": "gene", + "text": "They are present in many kinds of living things , but their functions , especially those in humans , are unclear .", + "entities": [] + }, + { + "id": "4401", + "type": "gene", + "text": "Cramps in extrapyramidal disorders .", + "entities": [] + }, + { + "id": "4402", + "type": "gene", + "text": "The high degree of conservation between NQO2 and NQO1 gene organization and sequence confirmed that NQO2 gene encodes for a second member of the NQO gene family in human .", + "entities": [ + "NQO2", + "NQO1 gene", + "NQO2 gene", + "NQO gene family" + ] + }, + { + "id": "4403", + "type": "gene", + "text": "The smaller uptake rate and faster clearance rate resulted in the lower BCF for SWA killifish .", + "entities": [] + }, + { + "id": "4404", + "type": "gene", + "text": "The disease ran an atypical course ; with early jaundice syndrome , severe enterorrhagia and late appearance of roseola .", + "entities": [] + }, + { + "id": "4405", + "type": "gene", + "text": "In serum - free media , p50E4F accelerated E1A - induced apoptosis .", + "entities": [ + "p50E4F", + "E1A" + ] + }, + { + "id": "4406", + "type": "gene", + "text": "EUK - 8 is a novel , synthetic , low - molecular - weight salen - manganese complex that exhibits both superoxide dismutase and catalase activities in vitro .", + "entities": [ + "superoxide dismutase", + "catalase" + ] + }, + { + "id": "4407", + "type": "gene", + "text": "Selected topics in pediatric ultrasonography - - 1992 .", + "entities": [] + }, + { + "id": "4408", + "type": "gene", + "text": "Selenium ( . 1 ppm ) and E ( 50 IU / kg ) supplementation of the diet of the sow increased plasma tocopherol and Se concentrations , but did not increase plasma glutathione peroxidase ( GSH - Px ) activity .", + "entities": [ + "plasma glutathione peroxidase", + "GSH - Px" + ] + }, + { + "id": "4409", + "type": "gene", + "text": "Indeed , mutation of two of these motifs , known to be important to regulation of sid1 , altered the differential regulation of sid2 by iron .", + "entities": [ + "sid1", + "sid2" + ] + }, + { + "id": "4410", + "type": "gene", + "text": "An immunologic test using stomach and tumor antigens for screening of those at high risk for stomach cancer is suggested .", + "entities": [] + }, + { + "id": "4411", + "type": "gene", + "text": "In a man with myelomonocytic leukemia , the association of increased prostatic acid phosphatase activity in serum and the presence of typical bone lesions on roentgenography suggested the existence of disseminated prostatic carcinoma .", + "entities": [ + "prostatic acid phosphatase" + ] + }, + { + "id": "4412", + "type": "gene", + "text": "A cDNA encoding a new human lymphocyte cell surface molecule has been isolated and shown to identify a fourth member of a recently discovered family of adhesion proteins .", + "entities": [] + }, + { + "id": "4413", + "type": "gene", + "text": "Comparative study of the differential white blood cell count using three automated analyzers : Coulter STKS , Sysmex NE 8000 and Technicon H - 1 .", + "entities": [] + }, + { + "id": "4414", + "type": "gene", + "text": "The vigilance task and the measurement of attentional deficits .", + "entities": [] + }, + { + "id": "4415", + "type": "gene", + "text": "In an effort to identify the USH1C disease gene we have isolated the region between these markers in yeast artificial chromosomes ( YACs ) using a combination of STS content mapping and Alu - PCR hybridization .", + "entities": [ + "USH1C disease gene", + "Alu" + ] + }, + { + "id": "4416", + "type": "gene", + "text": "Pet - 1 can bind specifically to a PEA3 ETS DNA - binding motif and can modulate transcription of synthetic promoter constructs in a sequence - specific manner .", + "entities": [ + "Pet - 1", + "ETS" + ] + }, + { + "id": "4417", + "type": "gene", + "text": "These results may suggest involvement of peripheral enkephalins in pain modulation in patients with episodic cluster headache .", + "entities": [] + }, + { + "id": "4418", + "type": "gene", + "text": "In children unable to perform forced expiratory maneuvers ( n = 25 ) , FOT , contrary to the interrupter technique , clearly identified a subgroup of young children with high resistance values at baseline , which returned to normal after bronchodilation .", + "entities": [] + }, + { + "id": "4419", + "type": "gene", + "text": "Cholesteryl ester transfer protein and atherosclerosis in Japanese subjects : a study based on coronary angiography .", + "entities": [ + "Cholesteryl ester transfer protein" + ] + }, + { + "id": "4420", + "type": "gene", + "text": "Responses to brainstem of nuclei medialis dorsalis , lateralis posterior were of considerably longer latency .", + "entities": [] + }, + { + "id": "4421", + "type": "gene", + "text": "The catenins bind to APC and E - cadherin in a similar fashion , but APC and E - cadherin do not associate with each other either in the presence or absence of catenins .", + "entities": [ + "catenins", + "APC", + "E - cadherin", + "APC", + "E - cadherin", + "catenins" + ] + }, + { + "id": "4422", + "type": "gene", + "text": "These data suggest that these sequences located immediately 3 ' to the breakpoint of the HPFH - 3 deletion , exhibit both the structure and the function of an enhancer , and can modify the developmental specificity of the fetal gamma - globin genes , resulting in their continued expression during adult life .", + "entities": [ + "HPFH - 3 deletion", + "fetal gamma - globin genes" + ] + }, + { + "id": "4423", + "type": "gene", + "text": "Sixteen other normal subjects with 2 g of Metyrapone are best responses .", + "entities": [] + }, + { + "id": "4424", + "type": "gene", + "text": "Changes in muscarinic acetylcholine receptors in guinea - pig lung : effects of aging , inhalation of an allergen , administration of drugs , and vagotomy .", + "entities": [ + "muscarinic acetylcholine receptors" + ] + }, + { + "id": "4425", + "type": "gene", + "text": "Twelve patients without abnormalities in the PTT are assumed to harbor missense mutations , probably in TSC2 .", + "entities": [ + "TSC2" + ] + }, + { + "id": "4426", + "type": "gene", + "text": "With aging , many aspects of immune function change .", + "entities": [] + }, + { + "id": "4427", + "type": "gene", + "text": "5 ) We ' ve noticed that the mean value of the cost for episode of pnx s . in class A was more than 15 % compared to class B and the cost for patient in class A was nearly double than in class B .", + "entities": [] + }, + { + "id": "4428", + "type": "gene", + "text": "We report here the molecular cloning of a putative adhesive molecule from P . falciparum that shares both sequence and structural similarities with a sporozoite surface molecule from Plasmodium termed the thrombospondin - related anonymous protein ( TRAP ) and , to a lesser extent , with the circumsporozoite ( CS ) protein .", + "entities": [ + "thrombospondin - related anonymous protein", + "TRAP", + "circumsporozoite ( CS ) protein" + ] + }, + { + "id": "4429", + "type": "gene", + "text": "The Cox proportional hazards model was applied to the data in order to determine the prognostic factors for long - term survival .", + "entities": [] + }, + { + "id": "4430", + "type": "gene", + "text": "An interatrial communication mitigates the impairment of LV function after an acute and sustained drop of intrathoracic pressure .", + "entities": [] + }, + { + "id": "4431", + "type": "gene", + "text": "EMSA showed that nuclear proteins from PC12 but not C6 or Rat2 cells bind the CRE as a complex containing activating transcription factor ( ATF ) - 4 and CCAAT enhancer - binding protein beta , while both PC12 and C6 cell nuclear extracts were recruited by the CCAAT - box as a complex containing nuclear factor Y .", + "entities": [ + "activating transcription factor ( ATF ) - 4", + "CCAAT enhancer - binding protein beta", + "nuclear factor Y" + ] + }, + { + "id": "4432", + "type": "gene", + "text": "Tumor necrosis factor - alpha ( TNF alpha ) is one of several autocrine / paracrine factors known to exert potent inhibitory effects on bone .", + "entities": [ + "Tumor necrosis factor - alpha", + "TNF alpha" + ] + }, + { + "id": "4433", + "type": "gene", + "text": "Specific hyperimmune globulins to pathogens such as Haemophilus influenzae and Streptococcus pneumoniae have also been studied .", + "entities": [ + "hyperimmune globulins" + ] + }, + { + "id": "4434", + "type": "gene", + "text": "E1A autoactivation mediated by these sites was about twofold compared with a ninefold activation described for the complete E1A promoter .", + "entities": [ + "E1A", + "E1A promoter" + ] + }, + { + "id": "4435", + "type": "gene", + "text": "A causal analysis of secondary variables showed that the formation of FB memories was primarily associated with the level of importance attached to the event and level of affective response to the news .", + "entities": [] + }, + { + "id": "4436", + "type": "gene", + "text": "In the lattice , 23 % of the sites are occupied , 95 % of the atoms are in the lowest energy magnetic sublevel , and 37 % are in the lowest 3D vibrational state .", + "entities": [] + }, + { + "id": "4437", + "type": "gene", + "text": "The zta transactivator involved in induction of lytic cycle gene expression in Epstein - Barr virus - infected lymphocytes binds to both AP - 1 and ZRE sites in target promoter and enhancer regions .", + "entities": [ + "zta transactivator", + "AP - 1", + "ZRE sites" + ] + }, + { + "id": "4438", + "type": "gene", + "text": "A prospective trial was undertaken to determine ( 1 ) clinical characteristics of patients with chest pain ; ( 2 ) value of cardiac markers troponin T , myoglobin and CK - MB mass in differentiating cardiac and noncardiac chest pain ; ( 3 ) the proportion of patients with ACS in whom these markers provided helpful additional information on admission and afterwards .", + "entities": [ + "troponin T", + "myoglobin", + "CK", + "MB" + ] + }, + { + "id": "4439", + "type": "gene", + "text": "Delayed gallbladder visualization and reduction in ejection fraction were sensitive but nonspecific indicators of biliary disease .", + "entities": [] + }, + { + "id": "4440", + "type": "gene", + "text": "Our previous study suggested that pertussis toxin ( IAP ) - sensitive GTP - binding protein ( s ) ( G - protein ) is involved in the process of differentiation by hormones / IBMX , accompanied by c - fos induction .", + "entities": [ + "pertussis toxin", + "IAP", + "GTP - binding protein ( s )", + "G - protein", + "c - fos" + ] + }, + { + "id": "4441", + "type": "gene", + "text": "After successful subtotal parathyroidectomy , evident by the decrease of serum iPTH levels , both the CL of group 2 PMNs and the ability of group 2 sera to induce augmented CL in normal PMNs decreased ( p < 0 . 025 ) .", + "entities": [ + "iPTH" + ] + }, + { + "id": "4442", + "type": "gene", + "text": "Southern blotting analysis implied the occurrence of multiple COXVb genes in the rat genome .", + "entities": [ + "COXVb genes" + ] + }, + { + "id": "4443", + "type": "gene", + "text": "We present evidence that YY1 , a ubiquitously expressed DNA - binding protein , regulates the activity of the c - fos promoter primarily through an effect on DNA structure .", + "entities": [ + "YY1", + "c - fos promoter" + ] + }, + { + "id": "4444", + "type": "gene", + "text": "A deletion mutation analysis of the recombinant protein has shown that the N - terminal region and the two leucine zippers are necessary for the binding .", + "entities": [] + }, + { + "id": "4445", + "type": "gene", + "text": "FOG is coexpressed with GATA - 1 during embryonic development and in erythroid and megakaryocytic cells .", + "entities": [ + "FOG", + "GATA - 1" + ] + }, + { + "id": "4446", + "type": "gene", + "text": "BACKGROUND : Checkpoint pathways prevent cell - cycle progression in the event of DNA lesions .", + "entities": [] + }, + { + "id": "4447", + "type": "gene", + "text": "Two episodes of peritonitis occurred while the patient received CAPD ( 1 episode / 3 . 5 patient - months ) .", + "entities": [] + }, + { + "id": "4448", + "type": "gene", + "text": "The presence of an unusual transcript possessing IVS2C beta 1 at the 5 ' terminus suggests that cleavage of its splice acceptor is inefficient or negatively regulated .", + "entities": [ + "IVS2C beta 1" + ] + }, + { + "id": "4449", + "type": "gene", + "text": "Recurrence of bladder tumors among the original 9 cases has occurred only among the 5 whose properdin levels remained below the median .", + "entities": [ + "properdin" + ] + }, + { + "id": "4450", + "type": "gene", + "text": "Preparation of a stable phospholipid reagent for coagulation assays .", + "entities": [] + }, + { + "id": "4451", + "type": "gene", + "text": "Assuming O2 consumption of the isolated skin to be same as in situ , calculations showed that when water PO2 was high ( 150 mm Hg ) , about 40 % of total cutaneous O2 uptake was consumed by the skin .", + "entities": [] + }, + { + "id": "4452", + "type": "gene", + "text": "Intron 8 harbored a strong erythroid - specific enhancer activity which was orientation - dependent .", + "entities": [] + }, + { + "id": "4453", + "type": "gene", + "text": "Comprehensive care of the patient exposed to a human teratogen may also include discussion of prenatal diagnostic procedures and other pregnancy management options .", + "entities": [] + }, + { + "id": "4454", + "type": "gene", + "text": "In Malmo , Sweden , 17 , 181 school children born in the years 1961 - 1965 were screened for scoliosis once a year between the ages of 7 and 16 years , during 1971 - 1980 .", + "entities": [] + }, + { + "id": "4455", + "type": "gene", + "text": "A putative inhibitor ( s ) appears to co - elute in the inactive fraction that blocked the L ( alpha ) activity .", + "entities": [ + "L ( alpha )" + ] + }, + { + "id": "4456", + "type": "gene", + "text": "Biochemical analysis shows that Ssm1p is a structural protein that forms part of the largest 60S ribosomal subunit , which does not exist in a pool of free proteins .", + "entities": [ + "Ssm1p", + "60S ribosomal subunit" + ] + }, + { + "id": "4457", + "type": "gene", + "text": "We found in the control subjects rCBF increases in regions associated with the meso - striatal and meso - corticolimbic circuits in response to both monetary reward and nonmonetary reinforcement .", + "entities": [] + }, + { + "id": "4458", + "type": "gene", + "text": "All the women received 13 . 5 mg plain bupivacaine via subarachnoid injection at the L2 - 3 interspace .", + "entities": [] + }, + { + "id": "4459", + "type": "gene", + "text": "In F42A - stimulated internalization assays on forskolin - induced YT - 1 cells , the IL - 2R alpha chain is consistently endocytosed together with the IL - 2R beta subunit indicating that IL - 2R alpha is stably associated with the F42A - IL - 2R beta complex even though the alpha - subunit contributes little if any affinity to the F42A binding reaction .", + "entities": [ + "IL - 2R alpha chain", + "IL - 2R beta subunit", + "IL - 2R alpha", + "F42A - IL - 2R beta complex" + ] + }, + { + "id": "4460", + "type": "gene", + "text": "Our results implicate TGF - beta RII as a direct target of EWS - FLI1 .", + "entities": [ + "TGF - beta RII", + "EWS", + "FLI1" + ] + }, + { + "id": "4461", + "type": "gene", + "text": "Molecular cloning of a P - type ATPase gene from the cyanobacterium Synechocystis sp .", + "entities": [ + "P - type ATPase gene" + ] + }, + { + "id": "4462", + "type": "gene", + "text": "We conclude that this new measurement technique provides an easy and accurate P0 . 1 measurement using standard respiratory equipment when tested in a lung model .", + "entities": [] + }, + { + "id": "4463", + "type": "gene", + "text": "A significant herd X period interaction existed for liver TG and serum dextran precipitable cholesterol concentrations .", + "entities": [] + }, + { + "id": "4464", + "type": "gene", + "text": "A combined series of patients experienced a TOL after two or more previous cesarean deliveries ; the rate of vaginal delivery was 66 % , and there was virtually no morbidity .", + "entities": [] + }, + { + "id": "4465", + "type": "gene", + "text": "The major inserted DNA has no significant homology to published human nucleic acid sequences .", + "entities": [] + }, + { + "id": "4466", + "type": "gene", + "text": "However , there was a difference in the quality of immunity : fever and body weight loss were seen in hamsters vaccinated with the killed - toxoplasma vaccine after they were challenge exposed with T - 1 strain , whereas these changes were rarely seen in hamsters given the live - toxoplasma vaccine and then challenge exposed with RH strain .", + "entities": [] + }, + { + "id": "4467", + "type": "gene", + "text": "Heterozygous mutation in the G + 5 position of intron 33 of the pro - alpha 2 ( I ) gene ( COL1A2 ) that causes aberrant RNA splicing and lethal osteogenesis imperfecta .", + "entities": [ + "pro - alpha 2 ( I ) gene", + "COL1A2" + ] + }, + { + "id": "4468", + "type": "gene", + "text": "In a model of the ternary complex , the segment of NFAT nearest AP - 1 is the Rel insert region ( RIR ) , a feature that is notable for its hypervariability in size and in sequence amongst members of the Rel transcription factor family .", + "entities": [ + "NFAT", + "AP - 1", + "Rel", + "Rel transcription factor family" + ] + }, + { + "id": "4469", + "type": "gene", + "text": "Troglitazone also induced an endogenous PPARgamma target gene in T24 cells , adipocyte - type fatty acid binding protein ( A - FABP ) , the expression of which correlates with bladder cancer differentiation .", + "entities": [ + "endogenous PPARgamma target gene", + "adipocyte - type fatty acid binding protein", + "A - FABP" + ] + }, + { + "id": "4470", + "type": "gene", + "text": "Deletions in each of these regions abolish membrane localization of Tiam1 and membrane ruffling , suggesting that they function cooperatively .", + "entities": [ + "Tiam1" + ] + }, + { + "id": "4471", + "type": "gene", + "text": "Strikingly , this subdomain is also present in the otherwise unrelated N - terminal activating region of p58c - ets - 2 and was thus named BEC for Ets - 1 - beta / Ets - 2 - Conserved sequence .", + "entities": [ + "p58c - ets - 2", + "BEC", + "Ets - 1 - beta", + "Ets - 2 - Conserved sequence" + ] + }, + { + "id": "4472", + "type": "gene", + "text": "The E - box sequence in the SE2 fragment of the transferrin promoter was CATCTG and was similar in gel shifts to the consensus E - box elements ( CANNTG ) previously characterized .", + "entities": [ + "SE2 fragment", + "transferrin promoter" + ] + }, + { + "id": "4473", + "type": "gene", + "text": "The apparent Kd of the MetRS / CAU operator complex is one order magnitude higher than that of the ThrRS / CGU operator complex .", + "entities": [ + "MetRS / CAU operator complex", + "ThrRS / CGU operator complex" + ] + }, + { + "id": "4474", + "type": "gene", + "text": "Our findings also provide the basis for the development of assays to screen for the ligands to testis receptor 2 and hERR1 .", + "entities": [ + "testis receptor 2", + "hERR1" + ] + }, + { + "id": "4475", + "type": "gene", + "text": "These results indicate that virulence - associated genes and their overall chromosomal arrangement are relatively well conserved between B . henselae and other gram - negative bacteria such as A . tumefaciens .", + "entities": [] + }, + { + "id": "4476", + "type": "gene", + "text": "This association was independently significant for patients treated primarily ( not for recurrence ) .", + "entities": [] + }, + { + "id": "4477", + "type": "gene", + "text": "On the basis of a patient ' s report of one inaccurate Clinitemp , we undertook to investigate the accuracy of this thermometer .", + "entities": [] + }, + { + "id": "4478", + "type": "gene", + "text": "Using an audiotape cassette and headphones the duration of the hallucinations decreased significantly .", + "entities": [] + }, + { + "id": "4479", + "type": "gene", + "text": "Replicating simian virus 40 ( SV40 ) chromosomes were found to be similar to other eukaryotic chromosomes in that the rate and extent of micrococcal nuclease ( MNase ) digestion were greater with replicating than with nonreplicating mature SV40 chromatin .", + "entities": [ + "micrococcal nuclease", + "MNase" + ] + }, + { + "id": "4480", + "type": "gene", + "text": "Treatment of suppurative peritonitis", + "entities": [] + }, + { + "id": "4481", + "type": "gene", + "text": "CIITA mRNA is normally inducible by IFN - gamma in class II non - inducible , RB - defective lines , and in one line , re - expression of RB has no effect on CIITA mRNA induction levels .", + "entities": [ + "CIITA mRNA", + "IFN - gamma", + "RB", + "CIITA mRNA" + ] + }, + { + "id": "4482", + "type": "gene", + "text": "A cDNA encoding a putative RNA and / or DNA helicase has been isolated from Arabidopsis thaliana cDNA libraries .", + "entities": [ + "RNA and / or DNA helicase" + ] + }, + { + "id": "4483", + "type": "gene", + "text": "Cortisone induced bone changes and its response to lipid clearing agents .", + "entities": [] + }, + { + "id": "4484", + "type": "gene", + "text": "Of 110 previously untreated patients who had entered the study of protocol TCL821 , 96 were evaluable .", + "entities": [] + }, + { + "id": "4485", + "type": "gene", + "text": "Finally , the recovery indexes represented by the times required for T1 / T0 and T4 / T1 to rise from 25 % to 75 % respectively were studied .", + "entities": [] + }, + { + "id": "4486", + "type": "gene", + "text": "X - linked liver glycogenosis : localization and isolation of a candidate gene .", + "entities": [] + }, + { + "id": "4487", + "type": "gene", + "text": "In most cases of acute transmural infarction , the reciprocal ST segment depressions observed in contralateral leads are less marked than the primary ST segment elevations .", + "entities": [] + }, + { + "id": "4488", + "type": "gene", + "text": "Comparison of the genomes of PMTV , BNYVV , and SBWMV shows that furoviruses exhibit considerable heterogeneity in genome organization .", + "entities": [] + }, + { + "id": "4489", + "type": "gene", + "text": "The exon - intron distribution of Cdebp appears strikingly similar to that of the App gene in the regions encoding the conserved domains , with a divergent structure in the other parts .", + "entities": [ + "Cdebp", + "App gene" + ] + }, + { + "id": "4490", + "type": "gene", + "text": "Therefore , the positive cAMP control of the hypoxic SRP1 and HEM13 genes was uncoupled from the HOG pathway .", + "entities": [ + "SRP1", + "HEM13 genes", + "HOG" + ] + }, + { + "id": "4491", + "type": "gene", + "text": "These cell lines displayed methylation of the CpG island surrounding the first exon of p16INK4A and expressed abundant levels of a nontranslated mRNA containing an alternative first exon ( E1 beta ) , as did all other cell lines in which the p16INK4A locus was not deleted .", + "entities": [ + "p16INK4A", + "p16INK4A locus" + ] + }, + { + "id": "4492", + "type": "gene", + "text": "CONCLUSION : The results demonstrate that at the site of lumbar disc herniation , inflammatory cytokines such as interleukin - 1 alpha are produced , which increases prostaglandin E2 production .", + "entities": [ + "interleukin - 1 alpha" + ] + }, + { + "id": "4493", + "type": "gene", + "text": "In vitro affinity analyses demonstrated that recombinant 130 - kD protein directly interacts with ZO - 1 and the cytoplasmic domain of occludin , but not with ZO - 2 .", + "entities": [ + "ZO - 1", + "occludin", + "ZO - 2" + ] + }, + { + "id": "4494", + "type": "gene", + "text": "We now report the isolation and expression of cDNAs encoding PTF gamma and PTF delta , as well as functional studies with cognate antibodies that recognize the native PTF complex in HeLa extracts .", + "entities": [ + "PTF gamma", + "PTF delta", + "PTF complex" + ] + }, + { + "id": "4495", + "type": "gene", + "text": "These results demonstrate that endogenous N - methylation of salsolinol into N - methylsalsolinol occurs in the brain in vivo .", + "entities": [] + }, + { + "id": "4496", + "type": "gene", + "text": "Two soybean cDNA clones , SPK - 3 and SPK - 4 , encoding putative protein kinases were isolated and characterized .", + "entities": [ + "SPK - 3", + "SPK - 4" + ] + }, + { + "id": "4497", + "type": "gene", + "text": "TH - SH3 binding in vitro is abolished by specific , single amino acid substitutions within the Btk TH domain or the Fyn SH3 domain .", + "entities": [ + "TH", + "SH3", + "TH domain", + "SH3 domain" + ] + }, + { + "id": "4498", + "type": "gene", + "text": "All our patients had polyps , 23 ( 54 % ) had asthma , 12 ( 27 % ) had aspirin sensitivity , 20 ( 65 % ) had eosinophilia , and 9 ( 69 % ) had increased total IgE levels .", + "entities": [ + "IgE" + ] + }, + { + "id": "4499", + "type": "gene", + "text": "Serum ferritin concentration and bone marrow iron stores .", + "entities": [ + "ferritin" + ] + }, + { + "id": "4500", + "type": "gene", + "text": "Ammonia concentration dropped significantly in all treatments , a finding which suggests a protective effect on protein nitrogen degradation to non - protein nitrogen ( NH3 ) .", + "entities": [] + }, + { + "id": "4501", + "type": "gene", + "text": "In some cases , the aberrant methylation of CpGs within 5 ' regulatory regions has led to suppression of gene activity .", + "entities": [] + }, + { + "id": "4502", + "type": "gene", + "text": "In order to investigate how these expression patterns are established , we fused promoter regions of an acidic and a basic glucanase gene to the beta - glucuronidase ( GUS ) reporter gene and examined expression of these constructs in transgenic tobacco plants .", + "entities": [ + "glucanase gene", + "beta - glucuronidase", + "GUS" + ] + }, + { + "id": "4503", + "type": "gene", + "text": "The roles of phorbol esters and cyclic AMP in mediating the GnRH response were also investigated .", + "entities": [ + "GnRH" + ] + }, + { + "id": "4504", + "type": "gene", + "text": "The Ras guanine nucleotide - binding protein functions as a molecular switch in signalling downstream of protein - tyrosine kinases .", + "entities": [ + "Ras guanine nucleotide - binding protein", + "protein - tyrosine kinases" + ] + }, + { + "id": "4505", + "type": "gene", + "text": "Chordoma of the spinal cord in a F344 rat .", + "entities": [] + }, + { + "id": "4506", + "type": "gene", + "text": "Furthermore , the initial plasma retinol level in conjunction with RBP was found to be even lower in 12 patients ( 35 . 1 micrograms dl - 1 , 3 . 7 mg dl - 1 ) who subsequently had cancer recurrence than in those who remained free of apparent cancer ( 44 . 5 micrograms dl - 1 , 4 . 6 mg dl - 1 ) .", + "entities": [ + "RBP" + ] + }, + { + "id": "4507", + "type": "gene", + "text": "Vascular responses to reactive hyperemia ( with flow increase leading to endothelium - dependent dilation ) and to sublingual glyceryl trinitrate ( GTN ; endothelium - independent dilation ) were recorded .", + "entities": [] + }, + { + "id": "4508", + "type": "gene", + "text": "The fepA - entD and fes - entF operons in the enterobactin synthesis and transport system are divergently transcribed from overlapping promoters , and both are inhibited by the Fur repressor protein under iron - replete conditions .", + "entities": [ + "fepA", + "entD", + "fes", + "entF", + "Fur repressor protein" + ] + }, + { + "id": "4509", + "type": "gene", + "text": "Although the extracellular domain of the TSH - R is sufficient for high affinity binding of TSH , we conclude that the hyt mutation in the fourth transmembrane domain eliminates TSH binding .", + "entities": [ + "TSH - R", + "TSH", + "TSH" + ] + }, + { + "id": "4510", + "type": "gene", + "text": "Selective visual attention involves dynamic interplay between attentional control systems and sensory brain structures .", + "entities": [] + }, + { + "id": "4511", + "type": "gene", + "text": "Colorimetric determination of urinary iron , chelated with deferoxamine B , using a single reagent", + "entities": [] + }, + { + "id": "4512", + "type": "gene", + "text": "In the absence of MHC class II , purified soluble D10 TCR bound to Staphylococcus aureus enterotoxin C2 with an association rate of 1 . 69 + / - 0 . 12 x 10 ( 4 ) M ( - 1 ) sec ( - 1 ) and a dissociation rate of 1 . 9 + / - 0 . 47 x 10 ( - 2 ) sec ( - 1 ) , giving a dissociation constant of 1 . 1 microM .", + "entities": [ + "MHC class II", + "purified soluble D10 TCR", + "Staphylococcus aureus enterotoxin C2" + ] + }, + { + "id": "4513", + "type": "gene", + "text": "Routine clinical analysis revealed lower hematocrit and hemoglobin , and elevated BUN and alkaline phosphatase in the treated group .", + "entities": [ + "hemoglobin", + "alkaline phosphatase" + ] + }, + { + "id": "4514", + "type": "gene", + "text": "Two major and one minor transcription initiation sites were assigned to positions + 1 and + 24 and position + 14 , respectively , by a combination of ribonuclease protection , primer extension , and 5 ' RACE analyses .", + "entities": [] + }, + { + "id": "4515", + "type": "gene", + "text": "Previous studies have shown that the pro - inflammatory cytokines tumor necrosis factor alpha and interferon gamma reduce the expression of the cystic fibrosis transmembrane conductance regulator ( CFTR ) gene ( CFTR ) in HT - 29 and T84 cells by acting post - transcriptionally .", + "entities": [ + "tumor necrosis factor alpha", + "interferon gamma", + "cystic fibrosis transmembrane conductance regulator", + "CFTR", + "CFTR" + ] + }, + { + "id": "4516", + "type": "gene", + "text": "In Group IV dogs that received alpha - MSH only during reperfusion , BAEPs were increased approximately 10 to 14 % more than in Group II during the late reperfusion period .", + "entities": [ + "alpha - MSH" + ] + }, + { + "id": "4517", + "type": "gene", + "text": "Hepatitis B virus and hepatoma .", + "entities": [] + }, + { + "id": "4518", + "type": "gene", + "text": "Pulmonary vascular resistance was not altered , ejection fraction remained unchanged and isovolumic relaxation period was lengthened ( 119 + / - 20 . 1 to 147 . 39 + / - 21 . 15 , P less than 0 . 05 ) .", + "entities": [] + }, + { + "id": "4519", + "type": "gene", + "text": "T cells express two isoforms of S6k1 : a 70 kDa cytoplasmic kinase and an 85 kDa isoform that has a classic nuclear localisation .", + "entities": [ + "S6k1" + ] + }, + { + "id": "4520", + "type": "gene", + "text": "Disruption demonstrates that CDC14 is an essential gene .", + "entities": [ + "CDC14" + ] + }, + { + "id": "4521", + "type": "gene", + "text": "Germ - free rabbits given mouse CRF - flora showed values quite different from control animals for most parameters , indicating unsuitability of mouse CRF flora to ' normalize ' rabbits .", + "entities": [] + }, + { + "id": "4522", + "type": "gene", + "text": "However , patients with isolated office hypertension had fewer previous cardiovascular complications .", + "entities": [] + }, + { + "id": "4523", + "type": "gene", + "text": "In the treatment of opioid naive patients who underwent surgery and received opioids for acute pain , oral ADL 8 - 2698 ( 6 . 0 mg ) improved the management of postoperative ileus ( POI ) by shortening the time to achieve normal bowel function and , ultimately , hospital stay .", + "entities": [] + }, + { + "id": "4524", + "type": "gene", + "text": "Each mRNA contained five or six internal uridine residues , which were transcribed using a mixture of UTP and thio - UTP .", + "entities": [] + }, + { + "id": "4525", + "type": "gene", + "text": "In cell lines transformed by BCR / ABL , CRKL was tyrosine phosphorylated , while CRK was not .", + "entities": [ + "BCR", + "ABL", + "CRKL", + "CRK" + ] + }, + { + "id": "4526", + "type": "gene", + "text": "However , parallax measurements showed that at 150K , collapse of Epon sections does not take place .", + "entities": [] + }, + { + "id": "4527", + "type": "gene", + "text": "3 activities of the factor II molecule in the newborn infant at term", + "entities": [ + "factor II" + ] + }, + { + "id": "4528", + "type": "gene", + "text": "The General Practice Research Database ( GPRD ) is the world ' s largest computerized database of anonymized longitudinal patient records from general practice and is a unique public health research tool .", + "entities": [] + }, + { + "id": "4529", + "type": "gene", + "text": "Serum ACTH did not respond to insulin and metyrapone .", + "entities": [ + "Serum ACTH", + "insulin" + ] + }, + { + "id": "4530", + "type": "gene", + "text": "As determined in a modified yeast two - hybrid system , mIRS3 bound strongly to the p85 subunit of phosphatidylinositol 3 - kinase .", + "entities": [ + "mIRS3", + "p85 subunit", + "phosphatidylinositol 3 - kinase" + ] + }, + { + "id": "4531", + "type": "gene", + "text": "Pituitary adenylate cyclase - activating polypeptide regulates prolactin promoter activity via a protein kinase A - mediated pathway that is independent of the transcriptional pathway employed by thyrotropin - releasing hormone .", + "entities": [ + "adenylate cyclase - activating polypeptide", + "prolactin promoter", + "protein kinase A", + "thyrotropin - releasing hormone" + ] + }, + { + "id": "4532", + "type": "gene", + "text": "This suggests that alaproclate acutely increases the responsiveness of postsynaptic muscarinic and alpha 1 adrenoceptors .", + "entities": [ + "muscarinic and alpha 1 adrenoceptors" + ] + }, + { + "id": "4533", + "type": "gene", + "text": "Single photon emission computerized tomography ( SPECT ) , by providing three - dimensional representation of myocardial Tl - 201 , offers promise for improved localization of CAD .", + "entities": [] + }, + { + "id": "4534", + "type": "gene", + "text": "These data provide the molecular tools for the final identification of the MKS and the MUL genes .", + "entities": [ + "MKS", + "MUL genes" + ] + }, + { + "id": "4535", + "type": "gene", + "text": "Various treatment modalities are reviewed in the context of the psychology as well as the physiology of severe intractable pain .", + "entities": [] + }, + { + "id": "4536", + "type": "gene", + "text": "Accumulation of the U4 / U6 duplex was relieved by overexpression of wild - type Prp44p .", + "entities": [ + "U4", + "U6", + "wild - type Prp44p" + ] + }, + { + "id": "4537", + "type": "gene", + "text": "Serum lactate dehydrogenase and haptoglobin levels were normal , and total bilirubin was only slightly elevated .", + "entities": [ + "lactate dehydrogenase", + "haptoglobin" + ] + }, + { + "id": "4538", + "type": "gene", + "text": "The addition of zidovudine did not influence this transfer .", + "entities": [] + }, + { + "id": "4539", + "type": "gene", + "text": "Five different subtypes of spondyloarthropathy ( SpA ) are now recognized .", + "entities": [] + }, + { + "id": "4540", + "type": "gene", + "text": "However , limited comparisons reveal domains in the NH2 and COOH termini that have a high degree of similarity suggesting functional conservation .", + "entities": [] + }, + { + "id": "4541", + "type": "gene", + "text": "The results obtained were as follows : The mitral valve orifice area ( MVA ) was significantly smaller in patients with type III of the LVIT flow velocity pattern than in patients with type I ( p less than 0 . 001 ) .", + "entities": [] + }, + { + "id": "4542", + "type": "gene", + "text": "BACKGROUND / AIMS : Hepatitis C and nonalcoholic fatty liver disease ( NAFL ) are the two most common forms of liver disease in the United States .", + "entities": [] + }, + { + "id": "4543", + "type": "gene", + "text": "It is postulated that altered blood flow , mediated through the well - known prostaglandin synthetase inhibitory effects of ibuprofen , resulted in tubular necrosis .", + "entities": [ + "prostaglandin synthetase" + ] + }, + { + "id": "4544", + "type": "gene", + "text": "On the basis of its bZIP structural homology , meq is perhaps the only member of the jun - fos gene family completely viral in origin .", + "entities": [ + "meq", + "jun", + "fos" + ] + }, + { + "id": "4545", + "type": "gene", + "text": "Prediction of the times of sandfly development", + "entities": [] + }, + { + "id": "4546", + "type": "gene", + "text": "This effect was abolished once the EM motif in the promoter - reporter construct was mutated , thus suggesting that the synergistic transactivation function of the TEF - 1 - Max heterotypic complex is mediated through binding of the complex to the EM motif .", + "entities": [ + "TEF - 1", + "Max" + ] + }, + { + "id": "4547", + "type": "gene", + "text": "Clone 39 was a homolog of CONSTANS , which is a gene involved in controlling the flowering time in Arabidopsis .", + "entities": [ + "CONSTANS" + ] + }, + { + "id": "4548", + "type": "gene", + "text": "In general , however , this study provided little evidence of any effect of supplementation to athletic performance for athletes consuming the dietary RDIs .", + "entities": [] + }, + { + "id": "4549", + "type": "gene", + "text": "Rev - erbAalpha / beta ) , Mxi - 1 and Mad bHLH - zip proteins and the oncoproteins PLZF and LAZ3 / BCL6 is mediated by the corepressors N - CoR and SMRT .", + "entities": [ + "Rev", + "erbAalpha / beta", + "Mxi - 1", + "Mad", + "PLZF", + "LAZ3", + "BCL6", + "N - CoR", + "SMRT" + ] + }, + { + "id": "4550", + "type": "gene", + "text": "Pitfalls in the use of chromosome aberration analysis for biological radiation dosimetry .", + "entities": [] + }, + { + "id": "4551", + "type": "gene", + "text": "Substantial amounts of liposomal ampicillin were recovered from isolated Kupffer cells , the target cells of L . monocytogenes after intravenous inoculation .", + "entities": [] + }, + { + "id": "4552", + "type": "gene", + "text": "The results supported the therapeutic principle of TCM : Treating patients according to their pathophysiological patterns .", + "entities": [] + }, + { + "id": "4553", + "type": "gene", + "text": "The degree of lung destruction , reflected by interstitial hemorrhage was assessed by measuring hemoglobin content in the fluid of the lavaged lungs .", + "entities": [ + "hemoglobin" + ] + }, + { + "id": "4554", + "type": "gene", + "text": "These CTD kinases , designated CTDK1 and CTDK2 , are fractionated by chromatography on Mono Q .", + "entities": [ + "CTD kinases", + "CTDK1", + "CTDK2" + ] + }, + { + "id": "4555", + "type": "gene", + "text": "Ras2p activates invasive growth using either of two downstream signaling pathways , the filamentation MAPK ( Cdc42p / Ste20p / MAPK ) cascade or the cAMP - dependent protein kinase ( Cyr1p / cAMP / PKA ) pathway .", + "entities": [ + "Ras2p", + "MAPK", + "Cdc42p", + "Ste20p", + "MAPK", + "cAMP - dependent protein kinase", + "Cyr1p", + "PKA" + ] + }, + { + "id": "4556", + "type": "gene", + "text": "Immunolocalization of Sop1p revealed a cytoplasmic distribution and cell fractionation studies showed that a significant fraction of Sop1p was recovered in a sedimentable fraction of the cytosolic material .", + "entities": [ + "Sop1p", + "Sop1p" + ] + }, + { + "id": "4557", + "type": "gene", + "text": "Susceptibility to ischemia - induced arrhythmias was lower in 1 - week diabetics : only 42 % of diabetic hearts exhibited ventricular tachycardia ( VT ) and 16 % had short episodes of ventricular fibrillation ( VF ) as compared to VT 100 % and VF 70 % ( including sustained VF 36 % ) in the non - diabetics ( P < 0 . 05 ) .", + "entities": [] + }, + { + "id": "4558", + "type": "gene", + "text": "A synergistic effect on HCK promoter activity was observed at high concentrations of Sp1 .", + "entities": [ + "HCK promoter", + "Sp1" + ] + }, + { + "id": "4559", + "type": "gene", + "text": "A pyrazolo - quinoline compound , 6 - methoxy - 4 - [ 2 - [ ( 2 - hydroxyethoxyl ) - ethyl ] amino ] - 3 - methyl - 1M - pyrazo lo [ 3 , 4 - b ] quinoline ( SCH 51344 ) , was identified based on its ability to derepress human smooth muscle alpha - actin promoter activity in ras - transformed cells .", + "entities": [ + "alpha - actin promoter", + "ras" + ] + }, + { + "id": "4560", + "type": "gene", + "text": "The 247 - kDa complex appears to contain two distinct protein - DNA complexes of approximately 232 and 256 kDa and represents two proteins covalently cross - linked to a single DRE oligonucleotide , while the 97 , 105 , and 115 - kDa complexes represent single protein - DRE cross - links .", + "entities": [] + }, + { + "id": "4561", + "type": "gene", + "text": "Group A ( 68 . 7 + / - 2 . 7 years ) consisted of patients with 0 or 1 risk factors ; B ( 68 . 3 + / - 4 . 2 years ) those with 2 risk factors ; and C ( 69 . 2 + / - 3 . 6 years ) those with 3 or more risk factors .", + "entities": [] + }, + { + "id": "4562", + "type": "gene", + "text": "There is no correlation between C2 - C3 disk morphology and the diskographically provoked response .", + "entities": [] + }, + { + "id": "4563", + "type": "gene", + "text": "Inherent hematology of old age", + "entities": [] + }, + { + "id": "4564", + "type": "gene", + "text": "Accurate pathologic staging identifies patients who are potentially curable with radiotherapy .", + "entities": [] + }, + { + "id": "4565", + "type": "gene", + "text": "Retrograde filling consists in sealing endodontics system directly at the apical zone after surgical approach .", + "entities": [] + }, + { + "id": "4566", + "type": "gene", + "text": "The gray matter NAA / mI ratio clearly separated the two groups .", + "entities": [] + }, + { + "id": "4567", + "type": "gene", + "text": "L - canavanine , a selective inhibitor of the inducible nitric oxide synthase , increases the mean systemic filling pressure , thereby improving venous return , under these conditions .", + "entities": [ + "nitric oxide synthase" + ] + }, + { + "id": "4568", + "type": "gene", + "text": "The centromedial amygdala and gastric pathology in rats .", + "entities": [] + }, + { + "id": "4569", + "type": "gene", + "text": "Only two of the isoforms possess the N - terminal zinc finger domain that is necessary and sufficient for TdT promoter binding .", + "entities": [ + "TdT promoter" + ] + }, + { + "id": "4570", + "type": "gene", + "text": "In both cities , HTLV - I / II prevalence increased significantly with age , and the New Orleans age - and sex - adjusted HTLV - I / II prevalence was significantly higher than that of Baltimore ( P less than . 001 ) .", + "entities": [] + }, + { + "id": "4571", + "type": "gene", + "text": "Moreover , PTax expressed higher background activities than PTF , indicating that the sequence of the synthetic regulatory region can influence background levels .", + "entities": [ + "PTax", + "PTF" + ] + }, + { + "id": "4572", + "type": "gene", + "text": "These results suggest that members of the ATF family are involved in mediating the transcriptional regulation of the KGF gene in response to extracellular stimuli via a novel CRE regulatory element .", + "entities": [ + "ATF family", + "KGF gene" + ] + }, + { + "id": "4573", + "type": "gene", + "text": "Previous transactivation experiments indicated that three amino acids residing in this region , Gly , Ser and Val , appear to be critical for target - site discrimination .", + "entities": [] + }, + { + "id": "4574", + "type": "gene", + "text": "CONCLUSION : The alpha2 - adrenergic antagonist idazoxan increases glucose - induced sympathetic activity but not energy expenditure in obese subjects .", + "entities": [] + }, + { + "id": "4575", + "type": "gene", + "text": "E2F - 6 shares significant homology with E2Fs 1 - 5 , especially within the DNA binding , heterodimerization and marked box domains .", + "entities": [ + "E2F - 6", + "E2Fs 1 - 5" + ] + }, + { + "id": "4576", + "type": "gene", + "text": "Therefore , the amino - terminal sequence of the purified carA product is identical to that derived from the nucleotide sequence in both organisms , P . stutzeri having four additional amino acids .", + "entities": [ + "carA product" + ] + }, + { + "id": "4577", + "type": "gene", + "text": "However , calphostin C , a specific inhibitor of PKC , abolished the TPA - induced increase in CFI mRNA levels .", + "entities": [ + "PKC", + "CFI mRNA" + ] + }, + { + "id": "4578", + "type": "gene", + "text": "The NR2 hybrid is a powerful tool for the mapping of new probes of this region , as well as for obtaining new informative probes specific for the deletion by subtractive cloning of the region .", + "entities": [] + }, + { + "id": "4579", + "type": "gene", + "text": "Genetic and molecular complexity of the position effect variegation modifier mod ( mdg4 ) in Drosophila .", + "entities": [ + "mod", + "mdg4" + ] + }, + { + "id": "4580", + "type": "gene", + "text": "mod ( mdg4 ) , also known as E ( var ) 3 - 93D , is involved in a variety of processes , such as gene silencing in position effect variegation ( PEV ) , the control of gypsy insulator sequences , regulation of homeotic gene expression , and programmed cell death .", + "entities": [ + "mod", + "mdg4", + "E ( var ) 3 - 93D", + "gypsy insulator sequences", + "homeotic gene" + ] + }, + { + "id": "4581", + "type": "gene", + "text": "A rat cDNA that encodes eIF - 5 has been isolated and expressed in Escherichia coli to yield a catalytically active eIF - 5 protein .", + "entities": [ + "eIF - 5", + "eIF - 5 protein" + ] + }, + { + "id": "4582", + "type": "gene", + "text": "Examples are using more subjects or an improved research design , developing consensus statements or using meta - analysis .", + "entities": [] + }, + { + "id": "4583", + "type": "gene", + "text": "The antibodies inhibited specifically the transcription of DNA polymerase alpha promoter in vitro .", + "entities": [ + "DNA polymerase alpha" + ] + }, + { + "id": "4584", + "type": "gene", + "text": "The Hagen - Poiseuille equation is used to assess the effects of attached parasites in the foregut of Leishmania - infected sandflies on blood flow .", + "entities": [] + }, + { + "id": "4585", + "type": "gene", + "text": "Among the few proteins of the eukaryotic nucleolus that have been characterized , four proteins , nucleolin , fibrillarin , SSB1 and NSR1 , possess a common structural motif , the GAR domain , which is rich in glycine and arginine residues .", + "entities": [ + "nucleolin", + "fibrillarin", + "SSB1", + "NSR1" + ] + }, + { + "id": "4586", + "type": "gene", + "text": "Total cumulative doses of doxorubicin ranged from 145 to 625 mg . / m . 2 .", + "entities": [] + }, + { + "id": "4587", + "type": "gene", + "text": "Influence of diet on urinary VMA excretion .", + "entities": [] + }, + { + "id": "4588", + "type": "gene", + "text": "REV I : All vessels up to 50 % stenosed have a patent graft .", + "entities": [] + }, + { + "id": "4589", + "type": "gene", + "text": "Through transient transfection of NIH3T3 fibroblast cells and gel mobility shift assays , the functional binding site was localized to a short region ( - 318 to - 303 bp from the transcription start site ) which has a CTCCC sequence .", + "entities": [] + }, + { + "id": "4590", + "type": "gene", + "text": "The mean value of the CD79b to the CD79b internally deleted ratio was 0 . 64 + / - 0 . 20 SD in normal donors and 0 . 44 + / - 0 . 27 SD in B - CLL ( P = . 01 ) .", + "entities": [ + "CD79b", + "CD79b" + ] + }, + { + "id": "4591", + "type": "gene", + "text": "Concomitant chronic lymphocytic leukemia , acute myeloid leukemia , and thrombosis with protein C deficiency .", + "entities": [ + "protein C" + ] + }, + { + "id": "4592", + "type": "gene", + "text": "GAP - N bound constitutively to p190 in both serum - deprived and growth factor - stimulated cells .", + "entities": [ + "GAP - N", + "p190" + ] + }, + { + "id": "4593", + "type": "gene", + "text": "The technical construction of the mouth protectors is illustrated , as is the need for instrumentation and its costs and the materials required to manufacture these mouth protectors .", + "entities": [] + }, + { + "id": "4594", + "type": "gene", + "text": "First , a pet54 : : LEU2 cytoductant bearing the ' short ' mitochondrial genome that lacks both COX1 introns aI5 alpha and aI5 beta is defective only in COX3 gene expression and not in COX1 mRNA splicing or mRNA translation .", + "entities": [ + "pet54", + "LEU2", + "aI5 alpha", + "aI5 beta", + "COX3 gene", + "COX1 mRNA" + ] + }, + { + "id": "4595", + "type": "gene", + "text": "The patient ' s role , organized by the prerequisites of expressive freedom , is counter posed with the psychoanalyst ' s , which is structured to empower listening and understanding .", + "entities": [] + }, + { + "id": "4596", + "type": "gene", + "text": "A novel phosphotyrosine - binding domain in the N - terminal transforming region of Cbl interacts directly and selectively with ZAP - 70 in T cells .", + "entities": [ + "Cbl", + "ZAP - 70" + ] + }, + { + "id": "4597", + "type": "gene", + "text": "GCD10 binds RNA in vitro and we present strong biochemical evidence that it is identical to the RNA - binding subunit of yeast initiation factor - 3 ( eIF - 3 ) .", + "entities": [ + "GCD10", + "yeast initiation factor - 3", + "eIF - 3" + ] + }, + { + "id": "4598", + "type": "gene", + "text": "eIF - 3 is a multisubunit complex that stimulates translation initiation in vitro at several different steps .", + "entities": [ + "eIF - 3" + ] + }, + { + "id": "4599", + "type": "gene", + "text": "Its expression pattern is representative of many B cell - specific proteins , which are essential for B cell development and activation but are down - regulated after B cells become terminally differentiated plasma cells .", + "entities": [] + }, + { + "id": "4600", + "type": "gene", + "text": "Overexpression of SCS1 could not complement an HSP60 - null allele , indicating that suppression was not due to the bypassing of Hsp60 activity .", + "entities": [ + "SCS1", + "HSP60 - null allele", + "Hsp60" + ] + }, + { + "id": "4601", + "type": "gene", + "text": "Administration of adrenaline resulted in a large overestimation of the SaO2 in 6 of the 7 measurements .", + "entities": [] + }, + { + "id": "4602", + "type": "gene", + "text": "During challenge , rebiopsy was done when reticulin antibodies turned positive ( mean 0 . 6 years , range 0 . 2 - 2 . 0 ) or at the end of the two year study .", + "entities": [ + "reticulin antibodies" + ] + }, + { + "id": "4603", + "type": "gene", + "text": "Postdocs face hardship across mainland Europe .", + "entities": [] + }, + { + "id": "4604", + "type": "gene", + "text": "Seventy - one percent of patients treated with ticarcillin alone responded favorably .", + "entities": [] + }, + { + "id": "4605", + "type": "gene", + "text": "Significance of delta - aminolevulinic acid analysis in clinical tests", + "entities": [] + }, + { + "id": "4606", + "type": "gene", + "text": "Alternatively , loss - of - function alleles of genes that inhibit cAPK lead to the inability to undergo sexual differentiation .", + "entities": [ + "cAPK" + ] + }, + { + "id": "4607", + "type": "gene", + "text": "The effect of the Ca entry blocker nitrendipine , the antioxidant superoxide dismutase ( SOD ) , and a combination of nitrendipine and superoxide dismutase on postischemic renal function was studied in four groups ( n = 24 ) of rats .", + "entities": [ + "superoxide dismutase", + "SOD", + "superoxide dismutase" + ] + }, + { + "id": "4608", + "type": "gene", + "text": "Both domains were required for specific DNA binding to the beta - retinoic acid receptor element , producing a DNase I footprint covering predominantly one strand .", + "entities": [ + "beta - retinoic acid receptor element", + "DNase I" + ] + }, + { + "id": "4609", + "type": "gene", + "text": "In Mv1Lu lung epithelial cells , ActR - IB and T beta R - I signal a common set of growth - inhibitory and transcriptional responses in association with their corresponding ligands and type II receptors .", + "entities": [ + "ActR - IB", + "T beta R - I", + "type II receptors" + ] + }, + { + "id": "4610", + "type": "gene", + "text": "These changes may be the result of , on the one hand , an increased sensitivity of the neuromuscular transmission and / or decreased muscle contractility and , on the other hand , the result of a reduced plasma clearance during hypothermia .", + "entities": [] + }, + { + "id": "4611", + "type": "gene", + "text": "Study on the evagination of Cysticercus pisiformis .", + "entities": [] + }, + { + "id": "4612", + "type": "gene", + "text": "RESULTS : In vivo , there was a wide distribution with the coefficient of variation ( SD / mean x 100 % ) for different valve sizes ranging from 21 % to 39 % in the St Jude Medical valve and from 25 % to 33 % in the Omnicarbon valve .", + "entities": [] + }, + { + "id": "4613", + "type": "gene", + "text": "The proposed algorithm consists of several steps .", + "entities": [] + }, + { + "id": "4614", + "type": "gene", + "text": "In support of clinical antianginal studies , the vasodilator nicorandil ( NIC ) was combined with the beta - adrenergic receptor antagonists propranolol ( PRO ) and atenolol ( ATN ) and with the calcium channel blocker diltiazem ( DTZ ) to determine their cardiovascular and pharmacokinetic interactions .", + "entities": [ + "beta - adrenergic receptor" + ] + }, + { + "id": "4615", + "type": "gene", + "text": "Proceedings : Reversible complete heart block following surgery of congenital heart defects", + "entities": [] + }, + { + "id": "4616", + "type": "gene", + "text": "Although isl - 1 binds to both the insulin and amylin gene promoter elements in vitro , these sequences display marked differences in their relative transcriptional properties when ligated adjacent to a heterologous promoter and transfected into InR1 - G9 islet cells .", + "entities": [ + "isl - 1", + "insulin", + "amylin gene promoter elements" + ] + }, + { + "id": "4617", + "type": "gene", + "text": "Bacteriol .", + "entities": [] + }, + { + "id": "4618", + "type": "gene", + "text": "RESULTS : Sixty per cent of African Americans exposed in 26 community outbreaks were TST positive compared to only 40 % of whites following comparable exposures .", + "entities": [] + }, + { + "id": "4619", + "type": "gene", + "text": "Its cognate binding protein , REST / NRSF , is an essential transcription factor ; its null mutations result in embryonic lethality , and its dominant negative mutants produce aberrant expression of neuron - specific genes .", + "entities": [ + "REST", + "NRSF" + ] + }, + { + "id": "4620", + "type": "gene", + "text": "Previous studies demonstrated that the flavin - containing monooxygenases ( FMO ) are expressed in a tissue - specific manner .", + "entities": [ + "flavin - containing monooxygenases", + "FMO" + ] + }, + { + "id": "4621", + "type": "gene", + "text": "The method has been routinely used in our laboratory for 1 year and has proven to be a reliable procedure for the biological control of occupational exposure to toluene and / or xylene .", + "entities": [] + }, + { + "id": "4622", + "type": "gene", + "text": "The coating materials were poloxamine 904 , poloxamine 908 , poloxamine 1508 , poloxamer 338 , and Brij 35 .", + "entities": [] + }, + { + "id": "4623", + "type": "gene", + "text": "Several dozen HIF - 1 targets are known , including the gene encoding vascular endothelial growth factor ( VEGF ) .", + "entities": [ + "HIF - 1 targets", + "vascular endothelial growth factor", + "VEGF" + ] + }, + { + "id": "4624", + "type": "gene", + "text": "Characterization and hormonal regulation of the promoter of the rat prostaglandin endoperoxide synthase 2 gene in granulosa cells .", + "entities": [ + "rat prostaglandin endoperoxide synthase 2 gene" + ] + }, + { + "id": "4625", + "type": "gene", + "text": "Transcription of the six EBNA genes , which are expressed in EBV - immortalized primary B cells , arises from one of two promoters , Cp and Wp , located near the left end of the viral genome .", + "entities": [ + "EBNA genes", + "Cp", + "Wp" + ] + }, + { + "id": "4626", + "type": "gene", + "text": "The ZNF274 gene is mapped distal to marker RP S28 1 in the human chromosome 19qter region , by RH mapping .", + "entities": [ + "ZNF274 gene" + ] + }, + { + "id": "4627", + "type": "gene", + "text": "The status of education and training programs in speech pathology and audiology - - 1971 - 72 .", + "entities": [] + }, + { + "id": "4628", + "type": "gene", + "text": "An N - terminal arm from each subunit wraps around the dinucleotide - binding domain of an adjacent subunit , covering the adenine ring of NADP .", + "entities": [] + }, + { + "id": "4629", + "type": "gene", + "text": "Treatment also led to a significant dose dependent reduction in the sum of ST segment depression at both trough and peak concentrations .", + "entities": [] + }, + { + "id": "4630", + "type": "gene", + "text": "DNA methylation , especially of either one or both of the deoxyadenosines at the two GATC motifs ( one in the first exon and the other in the first intron of the rice CatA gene ) , appeared to be responsible for the CatA promoter activity identified in the transient assay .", + "entities": [ + "CatA gene", + "CatA promoter" + ] + }, + { + "id": "4631", + "type": "gene", + "text": "The long - term prediction is based on an algorithm for R - R interval estimation .", + "entities": [] + }, + { + "id": "4632", + "type": "gene", + "text": "In budding yeast , the protein Skp1p , the cullin - family member Cdc53p , and the F - box / WD - repeat protein Cdc4p form the SCFCdc4p ubiquitin ligase complex , which targets the cyclin - dependent kinase ( Cdk ) inhibitor Sic1p for proteolysis [ 3 ] [ 4 ] [ 5 ] [ 6 ] [ 7 ] [ 8 ] .", + "entities": [ + "Skp1p", + "Cdc53p", + "Cdc4p", + "ubiquitin ligase", + "cyclin - dependent kinase", + "Cdk", + "Sic1p" + ] + }, + { + "id": "4633", + "type": "gene", + "text": "This caused severe cortical damage and neuronal loss in hippocampus subfields CA1 , CA3 , and hilus .", + "entities": [] + }, + { + "id": "4634", + "type": "gene", + "text": "Comparison of the nucleotide sequences between the human and bovine DNA showed that the sequence similarity extended 2400 bp downstream from the coding region .", + "entities": [] + }, + { + "id": "4635", + "type": "gene", + "text": "The rad9 . 192 DNA repair mutant from the fission yeast , Schizosaccharomyces pombe , is sensitive to both UV and ionising radiation .", + "entities": [ + "rad9 . 192 DNA repair mutant from the fission yeast , Schizosaccharomyces pombe" + ] + }, + { + "id": "4636", + "type": "gene", + "text": "Measurements were obtained : ( i ) just after the traumatic exposure ( D0 ) ; ( ii ) 3 days after this first measurement ( D3 ) ; and ( iii ) 30 days after ( D30 ) .", + "entities": [] + }, + { + "id": "4637", + "type": "gene", + "text": "Northern blot analysis of LeMT ( A ) and LeMT ( B ) showed that transcripts of both MT - like genes were more abundant in leaves than roots in tomato plants grown without addition of extra metal ions , a characteristic of type II MTs .", + "entities": [ + "LeMT ( A )", + "LeMT ( B )", + "MT - like genes", + "type II MTs" + ] + }, + { + "id": "4638", + "type": "gene", + "text": "Its application in Madagascar : advantages and disadvantages", + "entities": [] + }, + { + "id": "4639", + "type": "gene", + "text": "Recombinant human serum albumin ( rHSA ) produced by cultured fermentation has been prepared in the form of microcapsules nominally 3 - 5 microns in diameter and radiolabelled with technetium - 99m following reduction with stannous chloride .", + "entities": [ + "Recombinant human serum albumin", + "rHSA" + ] + }, + { + "id": "4640", + "type": "gene", + "text": "19 - 32 .", + "entities": [] + }, + { + "id": "4641", + "type": "gene", + "text": "METHODS : 126 patients with histologically confirmed MFH were analyzed .", + "entities": [] + }, + { + "id": "4642", + "type": "gene", + "text": "Statistics for nurse managers - - 3 .", + "entities": [] + }, + { + "id": "4643", + "type": "gene", + "text": "These data demonstrate that the STR family of genes is represented in a nematode whose ancestor appeared well before the branching that gave rise to the Arthropoda and Chordata .", + "entities": [ + "STR family" + ] + }, + { + "id": "4644", + "type": "gene", + "text": "The physical linkage of the FHR2 and the factor H genes provides additional evidence for a close relatedness of complement factor H and the factor H - related proteins .", + "entities": [ + "FHR2", + "factor H genes", + "complement factor H", + "factor H - related proteins" + ] + }, + { + "id": "4645", + "type": "gene", + "text": "A patient with an infected wound or one on a primary area ( hands , feet , face , or perineum ) may have to be hospitalized to ensure proper care .", + "entities": [] + }, + { + "id": "4646", + "type": "gene", + "text": "The RFX protein family includes members from yeast to humans , which function in various biological systems , and share a DNA - binding domain and a conserved C - terminal region .", + "entities": [ + "RFX protein family" + ] + }, + { + "id": "4647", + "type": "gene", + "text": "Organization of the bovine gene encoding the endothelial nitric oxide synthase .", + "entities": [ + "endothelial nitric oxide synthase" + ] + }, + { + "id": "4648", + "type": "gene", + "text": "Autopsy demonstrated good survival of the transplanted cells with good integration with the brain of the recipient and traces of positive immunocytochemical reaction for tyrosine hydroxylase .", + "entities": [ + "tyrosine hydroxylase" + ] + }, + { + "id": "4649", + "type": "gene", + "text": "Overproduction of HrcA protein from a second copy of hrcA derived from a plasmid ( phrcA + ) in B . subtilis wild - type and delta hrcA strains prevented heat shock induction of the dnaK and groE operons at the level of transcription almost completely and strongly reduced the amounts of mRNA at a low temperature as well .", + "entities": [ + "HrcA protein", + "hrcA", + "phrcA", + "hrcA", + "dnaK", + "groE operons" + ] + }, + { + "id": "4650", + "type": "gene", + "text": "Inhibition of the Raf - 1 kinase by cyclic AMP agonists causes apoptosis of v - abl - transformed cells .", + "entities": [ + "Raf - 1 kinase", + "v - abl" + ] + }, + { + "id": "4651", + "type": "gene", + "text": "We reviewed the records of 151 patients with optic neuritis examined over an eight - year period .", + "entities": [] + }, + { + "id": "4652", + "type": "gene", + "text": "Although inactive in cells under normal conditions , the CHOP gene is markedly induced by a variety of cellular stresses , including nutrient deprivation and metabolic perturbations .", + "entities": [ + "CHOP gene" + ] + }, + { + "id": "4653", + "type": "gene", + "text": "Among blood donors in the Republic of Serbia , regardless the number of blood donations , the percentage of female donors is significantly lower compared to the percentage of male blood donors .", + "entities": [] + }, + { + "id": "4654", + "type": "gene", + "text": "The gp330 / Megalin / LRP - 2 protein belongs to the low - density lipoprotein receptor gene family and is believed to function as an endocytic receptor for the uptake of lipoproteins and many other ligands .", + "entities": [ + "gp330", + "Megalin", + "LRP - 2", + "low - density lipoprotein receptor gene family" + ] + }, + { + "id": "4655", + "type": "gene", + "text": "CONCLUSION : More than 50 % of patients with perennial rhinitis and CRS do not improve after surgery , a response that may be predicted by more cells expressing IL - 5 mRNA in the ethmoid sinuses .", + "entities": [ + "IL - 5 mRNA" + ] + }, + { + "id": "4656", + "type": "gene", + "text": "Monitoring changes in the heart rate of the premature fetus during tocolysis with the beta - adrenomimetics partusisten and Pre - par", + "entities": [] + }, + { + "id": "4657", + "type": "gene", + "text": "The 11 ; 22 chromosomal translocation specifically linked to Ewing sarcoma and primitive neuroectodermal tumor results in a chimeric molecule fusing the amino - terminal - encoding portion of the EWS gene to the carboxyl - terminal DNA - binding domain encoded by the FLI1 gene .", + "entities": [ + "EWS gene", + "FLI1 gene" + ] + }, + { + "id": "4658", + "type": "gene", + "text": "Predictors of success in pharmacy school : PCAT vs . other admission criteria .", + "entities": [] + }, + { + "id": "4659", + "type": "gene", + "text": "Myocardial interstitial edema is more likely a potential mechanism of diastolic dysfunction after DC shocks .", + "entities": [] + }, + { + "id": "4660", + "type": "gene", + "text": "Cognitive visual dysfunction in a child with cerebral damage .", + "entities": [] + }, + { + "id": "4661", + "type": "gene", + "text": "Rss1p encodes a novel essential protein of 538 amino acids , which contains an extended predicted coiled - coil domain and is located both at nuclear pore complexes ( NPCs ) and in the cytoplasm .", + "entities": [ + "Rss1p" + ] + }, + { + "id": "4662", + "type": "gene", + "text": "Rep63A ( 513 amino acids [ aa ] ) , encoded by the largest ORF , displayed strong similarity ( 40 % identity ) to the replication proteins from plasmids pAMbeta1 , pIP501 , and pSM19035 , indicating that the pAW63 replicon belongs to the pAMbeta1 family of gram - positive theta - replicating plasmids .", + "entities": [ + "Rep63A ( 513 amino acids [ aa ] )" + ] + }, + { + "id": "4663", + "type": "gene", + "text": "In addition , our results show that ERKs and PI3Ks can synergise to convert ectoderm into mesoderm .", + "entities": [ + "ERKs", + "PI3Ks" + ] + }, + { + "id": "4664", + "type": "gene", + "text": "One enigmatic aspect of GATA factor expression is that several GATA proteins , which ostensibly share the same DNA - binding site specificity , are coexpressed in erythroid cells .", + "entities": [ + "GATA factor", + "GATA proteins" + ] + }, + { + "id": "4665", + "type": "gene", + "text": "The P - wr and P - rr cDNA sequences are very similar in their 5 ' regions .", + "entities": [ + "P - wr", + "P - rr cDNA sequences" + ] + }, + { + "id": "4666", + "type": "gene", + "text": "Biochemical characterization of valosin - containing protein , a protein tyrosine kinase substrate in hematopoietic cells .", + "entities": [ + "valosin - containing protein", + "protein tyrosine kinase" + ] + }, + { + "id": "4667", + "type": "gene", + "text": "Furthermore , rhoA - mediated SRE activation was blocked by dominant negative mutants of PKC - alpha or PKC - epsilon .", + "entities": [ + "rhoA", + "PKC - alpha", + "PKC - epsilon" + ] + }, + { + "id": "4668", + "type": "gene", + "text": "Identity of GABP with NRF - 2 , a multisubunit activator of cytochrome oxidase expression , reveals a cellular role for an ETS domain activator of viral promoters .", + "entities": [ + "GABP", + "NRF - 2", + "cytochrome oxidase", + "ETS domain" + ] + }, + { + "id": "4669", + "type": "gene", + "text": "The main issues are the need to explain a number of still unknown mechanisms , to determine which \" natural diet \" carries the minimum coronary risk and whether \" new \" foods produced by modern technology are really needed to contrast this epidemic .", + "entities": [] + }, + { + "id": "4670", + "type": "gene", + "text": "Paper alert .", + "entities": [] + }, + { + "id": "4671", + "type": "gene", + "text": "Polymerase chain reaction analysis of ETS1 cDNA identified several amplified products , indicating alternative splicing .", + "entities": [ + "ETS1 cDNA" + ] + }, + { + "id": "4672", + "type": "gene", + "text": "Regional blood blow was measured by means of microspheres in predefined regions of the C6 , T11 , and L6 vertebrae .", + "entities": [] + }, + { + "id": "4673", + "type": "gene", + "text": "Eight patients with ARC and renal failure were recently evaluated .", + "entities": [] + }, + { + "id": "4674", + "type": "gene", + "text": "This conclusion is based on the observations of the immunologic changes that characterize the acute stages of illness as well as on the demonstrated association with toxin - producing bacteria in the pharynx and gastrointestinal tract .", + "entities": [] + }, + { + "id": "4675", + "type": "gene", + "text": "Copyright 2000 Academic Press .", + "entities": [] + }, + { + "id": "4676", + "type": "gene", + "text": "A model with age and weight described the best fit for TBBMD , whereas age , weight , and height described the best fit for total body TBBMC .", + "entities": [] + }, + { + "id": "4677", + "type": "gene", + "text": "The ORF was analyzed for secondary structural features , and the sequence data bases were searched for homologies .", + "entities": [] + }, + { + "id": "4678", + "type": "gene", + "text": "The intensity of myocardial uptake of Tc - 99m - PYP in patients with echocardiographic left ventricular hypertrophy and / or highly refractile myocardial echoes , so - called granular sparkling appearance ( GS ) was slightly greater than that in patients with neither myocardial hypertrophy nor GS .", + "entities": [] + }, + { + "id": "4679", + "type": "gene", + "text": "We have addressed these issues by reconstituting and characterizing the KRAB : KAP - 1 - RBCC interaction using purified components .", + "entities": [ + "KRAB", + "KAP - 1", + "RBCC" + ] + }, + { + "id": "4680", + "type": "gene", + "text": "When extracorporeal CO2 removal approximated CO2 production ( VCO2 ) , alveolar ventilation almost ceased .", + "entities": [] + }, + { + "id": "4681", + "type": "gene", + "text": "Air ion action on bacteria .", + "entities": [] + }, + { + "id": "4682", + "type": "gene", + "text": "A comprehensive neuropsychological battery was administered to 48 veterans with Gulf War Illness ( GWI ) characterized by severe fatigue ( GV - F ) and 39 healthy veterans ( GV - H ) .", + "entities": [] + }, + { + "id": "4683", + "type": "gene", + "text": "To test promotor function , chimeric genes were constructed linking fragments of chicken IGF - I 5 ' - flanking DNA to a promoterless reporter plasmid .", + "entities": [ + "IGF - I" + ] + }, + { + "id": "4684", + "type": "gene", + "text": "Taken together , differences in signaling and tissue expression suggest that the human intermediate PRLr differs from the long PRLr in physiological function .", + "entities": [ + "human intermediate PRLr", + "long PRLr" + ] + }, + { + "id": "4685", + "type": "gene", + "text": "CONCLUSIONS : A 50 - mg daily dose of bicalutamide is sufficient when given in combination with an agent , such as a LHRH - A , that lowers serum testosterone , but higher doses of bicalutamide may be needed when the drug is given as monotherapy .", + "entities": [ + "LHRH" + ] + }, + { + "id": "4686", + "type": "gene", + "text": "The \" 28 percent \" Venturi mask in obstructive airway disease .", + "entities": [] + }, + { + "id": "4687", + "type": "gene", + "text": "To elucidate the regulatory mechanism of human AM gene expression , functional elements of 5 ' - flanking region of AM gene were studied in human aortic endothelial cells ( HAEC ) .", + "entities": [ + "human AM gene", + "AM gene" + ] + }, + { + "id": "4688", + "type": "gene", + "text": "These two mAbs used the same V ( H ) and J ( H ) gene segments , but different D , Vkappa , and Jkappa genes .", + "entities": [] + }, + { + "id": "4689", + "type": "gene", + "text": "Three different site - directed mutations of the cyclic AMP response element each reduced the nerve growth factor effect by > 90 % .", + "entities": [ + "nerve growth factor" + ] + }, + { + "id": "4690", + "type": "gene", + "text": "Flurazepam thus appears to be an effective hypnotic drug with the optimum dose for use in general practice being 15 mg at night .", + "entities": [] + }, + { + "id": "4691", + "type": "gene", + "text": "Expression of the CYP11A1 gene is increased by hormones , such as adrenocorticotropin and luteinizing hormone , as well as by a number of growth factors , suggesting that its promoter may contain regulatory elements that respond to multiple signal transduction pathways .", + "entities": [ + "CYP11A1 gene", + "adrenocorticotropin", + "luteinizing hormone" + ] + }, + { + "id": "4692", + "type": "gene", + "text": "The authors concluded that ultrasonic Doppler - cardiography can be used for measuring the relative changes in the stroke volume .", + "entities": [] + }, + { + "id": "4693", + "type": "gene", + "text": "Sings which are indicative of metaplastic erythropoiesis are absent .", + "entities": [] + }, + { + "id": "4694", + "type": "gene", + "text": "We have used a full - length cDNA clone of a mouse hepatitis virus strain A59 defective interfering ( DI ) RNA , pMIDI - C , and cassette mutagenesis to study the mechanism of coronavirus subgenomic mRNA synthesis .", + "entities": [ + "pMIDI - C" + ] + }, + { + "id": "4695", + "type": "gene", + "text": "In contrast , dig1 dig2 cells constitutively invade agar medium , whereas a dig1 dig2 ste12 triple mutant does not , indicating that Dig1 and Dig2 share a role in negatively regulating the invasive growth pathway .", + "entities": [ + "dig2", + "ste12", + "Dig1", + "Dig2" + ] + }, + { + "id": "4696", + "type": "gene", + "text": "Depending on treatment exposures , this at - risk population may experience life - threatening late effects , such as cirrhosis secondary to hepatitis C or late - onset anthracycline - induced cardiomyopathy , or life - changing late effects , such as cognitive dysfunction .", + "entities": [] + }, + { + "id": "4697", + "type": "gene", + "text": "The architecture of microvasculature in these two regions was also examined by scanning electron microscopy , using the resin casting method .", + "entities": [] + }, + { + "id": "4698", + "type": "gene", + "text": "However , after repeated infections , hypobiotic larvae were numerous .", + "entities": [] + }, + { + "id": "4699", + "type": "gene", + "text": "RESULTS : Coronary mortality during the median follow - up time of 17 months was 6 - fold higher in the highest tertile for CRP and IL - 6 and 3 . 5 - fold higher in the highest tertile for fibrinogen and TNF - alpha than in the respective combined lower tertiles .", + "entities": [ + "CRP", + "IL - 6", + "fibrinogen", + "TNF - alpha" + ] + }, + { + "id": "4700", + "type": "gene", + "text": "Quinone - binding domain and amino acid residues involved in quinone binding .", + "entities": [] + }, + { + "id": "4701", + "type": "gene", + "text": "These analyses demonstrate that the dUTPase isoforms are encoded by the same gene with isoform - specific transcripts arising through the use of alternative 5 ' exons .", + "entities": [ + "dUTPase" + ] + }, + { + "id": "4702", + "type": "gene", + "text": "The gene organization of CRSV RNA - 1 is similar to those of red clover necrotic mosaic ( RCNMV ) and sweet clover necrotic mosaic ( SCNMV ) dianthoviruses with the exception that CRSV RNA - 1 contains the additional 3 ' - terminal ORF .", + "entities": [ + "CRSV RNA - 1", + "CRSV RNA - 1" + ] + }, + { + "id": "4703", + "type": "gene", + "text": "The effect of low - profile serine substitutions in the V3 loop of HIV - 1 gp120 IIIB / LAI on the immunogenicity of the envelope protein .", + "entities": [ + "V3", + "gp120 IIIB", + "LAI", + "envelope" + ] + }, + { + "id": "4704", + "type": "gene", + "text": "Hantaan virus .", + "entities": [] + }, + { + "id": "4705", + "type": "gene", + "text": "In addition , lexical priming was examined by presenting an identity prime earlier in the text .", + "entities": [] + }, + { + "id": "4706", + "type": "gene", + "text": "3 - - It is necessary to think about cosmetic consequences of the chinese flap and consider other possibilities of the flap choice .", + "entities": [] + }, + { + "id": "4707", + "type": "gene", + "text": "Expression of six genes , ipaB , ipaC , invE , invG , invJ , and invK , was apparently regulated by the positive regulator virF .", + "entities": [ + "ipaB", + "ipaC", + "invE", + "invG", + "invJ", + "invK", + "virF" + ] + }, + { + "id": "4708", + "type": "gene", + "text": "This element , termed CREsp - a ( TGACCTCA ) , differs by one nucleotide from a palindromic CRE ( CREpal , TGACGTCA ) , which is known to bind CREB as a homodimer .", + "entities": [ + "CREB" + ] + }, + { + "id": "4709", + "type": "gene", + "text": "The term osteomesopycnosis is proposed for a sclerosing bone disease with dominant inheritance that has been discovered in five members of four different families .", + "entities": [] + }, + { + "id": "4710", + "type": "gene", + "text": "Group A was treated with three or four doses of hepatitis B immune globulin ( HBIG ) in one of three different schedules .", + "entities": [ + "hepatitis B immune globulin", + "HBIG" + ] + }, + { + "id": "4711", + "type": "gene", + "text": "RNase protection experiments confirmed the presence of the GHR1 - 279 variant in IM - 9 cells and human liver .", + "entities": [ + "RNase", + "GHR1 - 279 variant" + ] + }, + { + "id": "4712", + "type": "gene", + "text": "High - affinity site - specific DNA binding by POU domain transcription factors requires both the POU - specific and the POU - homeodomain .", + "entities": [ + "POU domain transcription factors", + "POU - specific", + "POU - homeodomain" + ] + }, + { + "id": "4713", + "type": "gene", + "text": "The 65 - bp sequence contains the octameric cAMP - responsive enhancer ( CRE ) TGACGTCA ( nucleotides - 48 to - 41 ) .", + "entities": [] + }, + { + "id": "4714", + "type": "gene", + "text": "CONCLUSIONS : Pretreatment with OCs prior to pituitary suppression in the early follicular phase decreases ovarian cyst formation , without an apparent effect on subsequent follicular recruitment or pregnancy rates .", + "entities": [] + }, + { + "id": "4715", + "type": "gene", + "text": "Unfolding can be described by a two - state process since a ratio of delta Hcalorimetric to delta Hvan ' t Hoff equals 0 . 96 .", + "entities": [] + }, + { + "id": "4716", + "type": "gene", + "text": "CONCLUSION : Local control was highest with Preop in patients presenting primarily with gross disease , and with Postop in patients presenting primarily following gross total excision .", + "entities": [] + }, + { + "id": "4717", + "type": "gene", + "text": "Etiopathogenetic and therapeutic problems in acute orbital inflammation", + "entities": [] + }, + { + "id": "4718", + "type": "gene", + "text": "Bioplastique granuloma presents with irregularly shaped cystic spaces of varying size containing jagged , translucent , nonbirefringent foreign bodies whereas Artecoll granuloma shows numerous round vacuoles nearly identical in size and shape enclosing round and sharply circumscribed , translucent , nonbirefringent foreign bodies .", + "entities": [] + }, + { + "id": "4719", + "type": "gene", + "text": "Pseudocontact shifts arise from the isotropic reorientational average of the dipolar coupling between unpaired electron and nuclei , in the presence of magnetic susceptibility anisotropy .", + "entities": [] + }, + { + "id": "4720", + "type": "gene", + "text": "Histological signs of the flare - up reaction were already present at 6 hr after i . v . challenge and lasted for at least 4 days .", + "entities": [] + }, + { + "id": "4721", + "type": "gene", + "text": "In contrast to this mRNA , 90 % of alpha and beta actin mRNAs were translated in both myoblasts and myotubes .", + "entities": [ + "alpha and beta actin mRNAs" + ] + }, + { + "id": "4722", + "type": "gene", + "text": "Using Ki - ras - transformed 3T3 cells as a model system , we show that both RA and the ' dissociating ' retinoids inhibit anchorage - independent cell proliferation , suggesting that retinoid - induced growth inhibition may be related to AP1 transrepression .", + "entities": [ + "Ki - ras", + "AP1" + ] + }, + { + "id": "4723", + "type": "gene", + "text": "Independent protrudor muscle stimulation increased VI , max ( peak increase 61 % , P < 0 . 05 ) , did not change Pcrit , and decreased Rn ( peak decrease of 41 % , P < 0 . 05 ) .", + "entities": [] + }, + { + "id": "4724", + "type": "gene", + "text": "The two different phosphoforms of STAT5 have identical in vitro DNA binding specificity and reactivity with tyrosine phosphopeptides , but differ in their cellular localization .", + "entities": [ + "STAT5" + ] + }, + { + "id": "4725", + "type": "gene", + "text": "In the present study , we characterized cis - elements of the human PCI gene required for expression in the hepatoma - derived cell line , HepG2 cells , and also evaluated rat PCI mRNA expression , particularly on the effect of androgen in rat reproductive tissues .", + "entities": [ + "human PCI gene", + "rat PCI mRNA" + ] + }, + { + "id": "4726", + "type": "gene", + "text": "Members of the AP - 1 superfamily of basic - leucine zipper factors bind to the StRE .", + "entities": [ + "AP - 1 superfamily of basic - leucine zipper factors" + ] + }, + { + "id": "4727", + "type": "gene", + "text": "The sequence of the repressor locus , c , of the Streptomyces temperate phage , phi C31 , was shown previously to contain an open reading frame encoding a 74 kDa protein .", + "entities": [] + }, + { + "id": "4728", + "type": "gene", + "text": "To examine the role of this CE2 element in regulating Hoxa1 expression in vivo , transgenic mice were generated which express a Hoxa1 beta - galactosidase reporter gene that contains a mutation in the CE2 element .", + "entities": [ + "Hoxa1", + "beta - galactosidase" + ] + }, + { + "id": "4729", + "type": "gene", + "text": "Sensory kindling : implications for development of sensory prostheses .", + "entities": [] + }, + { + "id": "4730", + "type": "gene", + "text": "Histological observations on the decidua in the second half of pregnancy", + "entities": [] + }, + { + "id": "4731", + "type": "gene", + "text": "The science of tissue engineering .", + "entities": [] + }, + { + "id": "4732", + "type": "gene", + "text": "On line calculation of steroid concentrations by radioimmunoassay", + "entities": [] + }, + { + "id": "4733", + "type": "gene", + "text": "Phosphocreatine hydrolysis during submaximal exercise : the effect of FIO2 .", + "entities": [] + }, + { + "id": "4734", + "type": "gene", + "text": "The DNA sequences upstream of these termini exhibit homology to plant mitochondrial - processing sites , therefore the proximal 5 ' ends are most probably generated by RNA processing .", + "entities": [] + }, + { + "id": "4735", + "type": "gene", + "text": "Biochemical examinations of calcium - phosphorus metabolism included ions and PTH concentrations in blood serum , and the activity of bone isoenzyme of AP .", + "entities": [ + "PTH", + "AP" + ] + }, + { + "id": "4736", + "type": "gene", + "text": "Derivatives of fluorene .", + "entities": [] + }, + { + "id": "4737", + "type": "gene", + "text": "The M reading frame differed from the reported sequence by a single nucleotide corresponding to a conservative lysine to arginine amino acid substitution near the carboxy - terminus conserved among the M proteins of paramyxoviruses .", + "entities": [ + "M reading frame", + "M proteins" + ] + }, + { + "id": "4738", + "type": "gene", + "text": "Inhibition of JNK1 and ERK kinase activities either by expression of the dominant negative mutant JNK1 or by treatment with a selective chemical inhibitor of ERK ( PD098059 ) substantially abrogates the UV induction of the GADD45 promoter .", + "entities": [ + "JNK1", + "ERK", + "JNK1", + "ERK", + "GADD45 promoter" + ] + }, + { + "id": "4739", + "type": "gene", + "text": "The predicted amino acid sequence contains regions identical to the sequences of peptides derived from bovine liver eIF - 2B alpha subunit .", + "entities": [ + "bovine liver eIF - 2B alpha subunit" + ] + }, + { + "id": "4740", + "type": "gene", + "text": "Addition of Rap or KN62 after exposure of cells to progesterone agonist Org 2058 had no effect on induction of CAT activity .", + "entities": [ + "CAT" + ] + }, + { + "id": "4741", + "type": "gene", + "text": "This gene joins the group of genes whose members are rapidly transcribed in response to insulin and other mitogens .", + "entities": [ + "insulin" + ] + }, + { + "id": "4742", + "type": "gene", + "text": "The PEBP2 alpha proteins contain a 128 - amino - acid ( aa ) region highly homologous to the Drosophila melanogaster segmentation gene runt .", + "entities": [ + "PEBP2 alpha proteins", + "Drosophila melanogaster segmentation gene runt" + ] + }, + { + "id": "4743", + "type": "gene", + "text": "Together these data imply that the HFV R region acts in the nucleus to modify the cytoplasmic fate of target HFV mRNA .", + "entities": [ + "HFV R region" + ] + }, + { + "id": "4744", + "type": "gene", + "text": "The rho genes comprise an evolutionarily conserved family with significant homology to the ras oncogene family .", + "entities": [ + "rho genes", + "ras oncogene family" + ] + }, + { + "id": "4745", + "type": "gene", + "text": "The persistent fetal dispersion of nodal and Hiss bundle fragments within the ventricular septum is proposed as a possible explanation .", + "entities": [] + }, + { + "id": "4746", + "type": "gene", + "text": "Acute inhalation toxicity of T - 2 mycotoxin in mice .", + "entities": [] + }, + { + "id": "4747", + "type": "gene", + "text": "Patulin is extracted from apple butter samples with ethyl acetate and the extract is cleaned up on a silica gel column , using benzene - ethyl acetate ( 75 + 25 ) as the eluant .", + "entities": [] + }, + { + "id": "4748", + "type": "gene", + "text": "We have previously reported that expression of a tumour derived brk cDNA in mouse embryonic fibroblasts and human mammary epithelial cells supports anchorage independent growth , and in the latter potentiates the mitogenic response to epidermal growth factor .", + "entities": [ + "brk cDNA", + "epidermal growth factor" + ] + }, + { + "id": "4749", + "type": "gene", + "text": "Prostaglandins and gallstones", + "entities": [] + }, + { + "id": "4750", + "type": "gene", + "text": "Coexposure to FP also resulted in a more pronounced and sustained activation of the mitogen - activated protein kinase kinase / extracellular signal - regulated protein kinase cascade after PMA treatment , although disruption of this pathway by the mitogen - activated protein kinase kinase 1 inhibitor U0126 did not prevent potentiation of apoptosis .", + "entities": [ + "mitogen - activated protein kinase kinase", + "extracellular signal - regulated protein kinase", + "mitogen - activated protein kinase kinase 1" + ] + }, + { + "id": "4751", + "type": "gene", + "text": "Biol .", + "entities": [] + }, + { + "id": "4752", + "type": "gene", + "text": "Examination of various promoter deletion mutants indicated that SF - 1 acts through the proximal promoter region and upstream promoter sequences .", + "entities": [ + "SF - 1" + ] + }, + { + "id": "4753", + "type": "gene", + "text": "The therapeutic use of botulinum toxin ( Botox ) is increasing in popularity .", + "entities": [ + "botulinum toxin", + "Botox" + ] + }, + { + "id": "4754", + "type": "gene", + "text": "Identical components of yeast transcription factor IIIB are required and sufficient for transcription of TATA box - containing and TATA - less genes .", + "entities": [ + "transcription factor IIIB" + ] + }, + { + "id": "4755", + "type": "gene", + "text": "Expression from this element is regulated by a heteromeric protein complex containing ubiquitous ( i . e . the E2A - and HEB - encoded proteins ) and islet - enriched members of the bHLH family .", + "entities": [ + "E2A", + "HEB - encoded proteins", + "bHLH family" + ] + }, + { + "id": "4756", + "type": "gene", + "text": "Among mammalian HSFs , HSF1 has been shown to be important for regulation of the heat - induced stress gene expression , whereas the function of HSF2 in stress response is unclear .", + "entities": [ + "mammalian HSFs", + "HSF1", + "HSF2" + ] + }, + { + "id": "4757", + "type": "gene", + "text": "TPA and TGF - beta 1 did not markedly affect the activities of the 72 - kDa enzyme .", + "entities": [ + "TGF - beta 1" + ] + }, + { + "id": "4758", + "type": "gene", + "text": "The control group included 8 afterbirth samples from physiological full - term pregnancies .", + "entities": [] + }, + { + "id": "4759", + "type": "gene", + "text": "In addition , in vitro mutagenesis of both Engrailed and Pbx1 sites indicated that other unidentified sites are responsible for the transcriptional enhancement observed with the intronic fragment .", + "entities": [ + "Engrailed", + "Pbx1 sites" + ] + }, + { + "id": "4760", + "type": "gene", + "text": "In studies of many different phenotypically distinct cells , the CRE of the somatostatin gene promoter is a prototype of a highly cAMP - responsive element regulated by CREB .", + "entities": [ + "somatostatin gene promoter", + "CREB" + ] + }, + { + "id": "4761", + "type": "gene", + "text": "Forskolin significantly enhanced heregulin - stimulated expression of cyclin D and phosphorylation of the retinoblastoma gene product .", + "entities": [ + "heregulin", + "cyclin D", + "retinoblastoma gene product" + ] + }, + { + "id": "4762", + "type": "gene", + "text": "Tumour necrosis factor and adult respiratory distress syndrome .", + "entities": [ + "Tumour necrosis factor" + ] + }, + { + "id": "4763", + "type": "gene", + "text": "CONCLUSION : Vitrectomy for vitreous hemorrhage in Terson syndrome is a safe and effective procedure , offering a rapid and prolonged improvement in vision .", + "entities": [] + }, + { + "id": "4764", + "type": "gene", + "text": "Nucleotide sequence analysis of R has revealed similarities to the R1 plasmid found in some South American maize races with RU cytoplasm , to the M1 plasmid found in one source of Zea luxurians teosinte , to the atp9 mitochondrial gene and its 3 ' flanking sequence , and also to a region 3 ' to the orf221 gene .", + "entities": [ + "atp9 mitochondrial gene", + "orf221 gene" + ] + }, + { + "id": "4765", + "type": "gene", + "text": "When the downstream operator was altered , there was a fourfold reduction in reporter enzyme levels .", + "entities": [] + }, + { + "id": "4766", + "type": "gene", + "text": "Our results , when combined with previously published in vitro results , support a direct role for Prp44p in unwinding of the U4 / U6 helix .", + "entities": [ + "Prp44p", + "U4", + "U6" + ] + }, + { + "id": "4767", + "type": "gene", + "text": "We have identified a strong Tas - responsive element , designated TRE ( GP ) , near the 3 ' end of the gag gene and preceding the pol gene of SFV - 1 .", + "entities": [ + "Tas - responsive element", + "TRE", + "GP", + "gag gene", + "pol gene" + ] + }, + { + "id": "4768", + "type": "gene", + "text": "A quantitative analysis of the diffraction intensity as function of the accumulated electron dose suggests the possibility of recording up to 250 diffraction patterns with 3 . 5 A resolution from a single crotoxin complex crystal 128 A thick .", + "entities": [] + }, + { + "id": "4769", + "type": "gene", + "text": "Typical and atypical clinical features of this lacrimal sac cyst are emphasized .", + "entities": [] + }, + { + "id": "4770", + "type": "gene", + "text": "Disrupted vaccines and whole - virus vaccines containing type B antigen only did not cause significant reactivity .", + "entities": [ + "type B antigen" + ] + }, + { + "id": "4771", + "type": "gene", + "text": "Coexpression studies indicate that insulin and PKB suppress transactivation by C / EBPbeta , but not C / EBPalpha , and that N - terminal transactivation domains in C / EBPbeta are required .", + "entities": [ + "insulin", + "PKB", + "C / EBPbeta", + "C / EBPalpha", + "C / EBPbeta" + ] + }, + { + "id": "4772", + "type": "gene", + "text": "The results of a quantitative study of vasculosyncytial membranes in 123 placentas are presented .", + "entities": [] + }, + { + "id": "4773", + "type": "gene", + "text": "The growth - promoting properties of the retroviral v - erbA oncogene , a highly mutated version of the chicken thyroid hormone receptor ( TR ) alpha , have so far exclusively been linked to dominant repression of the antimitogenic roles of TR and retinoic acid receptors .", + "entities": [ + "retroviral v - erbA oncogene", + "chicken thyroid hormone receptor ( TR ) alpha", + "TR", + "retinoic acid receptors" + ] + }, + { + "id": "4774", + "type": "gene", + "text": "The genes at each locus are divergently transcribed and the coding sequences are separated by 646 base - pairs at one locus and 676 base - pairs at the other .", + "entities": [] + }, + { + "id": "4775", + "type": "gene", + "text": "Nitric oxide inhalation selectively reduces pulmonary hypertension in porcine endotoxin shock and improves arterial oxygenation and pH with a marked attenuation of sympathetic activation .", + "entities": [] + }, + { + "id": "4776", + "type": "gene", + "text": "A single N - glycosylation site present in chicken gp42 is conserved among all five of these proteins : carbohydrate analysis of gp42 revealed the presence of a complex type glycan chain at this site .", + "entities": [ + "chicken gp42", + "gp42" + ] + }, + { + "id": "4777", + "type": "gene", + "text": "The three isoforms purified with anti - FLAG antibody affinity column transferred sulfate to heparan sulfate and heparin but not to other glycosaminoglycans .", + "entities": [ + "anti - FLAG antibody" + ] + }, + { + "id": "4778", + "type": "gene", + "text": "Analysis of the deduced amino acid sequence suggests that CHIP28 protein contains six bilayer - spanning domains , two exofacial potential N - glycosylation sites , and intracellular N and C termini .", + "entities": [ + "CHIP28 protein" + ] + }, + { + "id": "4779", + "type": "gene", + "text": "Both mu and gamma 2b heavy chain genes cause this feedback inhibition of heavy chain gene rearrangement .", + "entities": [ + "mu and gamma 2b heavy chain genes" + ] + }, + { + "id": "4780", + "type": "gene", + "text": "Spinal cord representation of the micturition reflex .", + "entities": [] + }, + { + "id": "4781", + "type": "gene", + "text": "In contrast , high COUP - TFI expression impeded the neuronal differentiation of P19 cells induced with RA , resulting in cell cultures lacking neurons .", + "entities": [ + "COUP - TFI" + ] + }, + { + "id": "4782", + "type": "gene", + "text": "A further subdivision of Category pN1 into pN1a ( metastasis in single node ) and pN1b ( two or more nodes ) is recommended .", + "entities": [] + }, + { + "id": "4783", + "type": "gene", + "text": "The RING finger , B2 box , and coiled - coil region are required for oligomerization of KAP - 1 - RBCC and KRAB binding , as mutations in these domains concomitantly abolished these functions .", + "entities": [ + "KAP - 1", + "RBCC", + "KRAB" + ] + }, + { + "id": "4784", + "type": "gene", + "text": "The 5 ' - flanking region of the human lactoferrin gene was isolated from a human placental genomic library .", + "entities": [ + "human lactoferrin gene" + ] + }, + { + "id": "4785", + "type": "gene", + "text": "Northern analysis indicated differential expression by tissue with highest expression in the heart .", + "entities": [] + }, + { + "id": "4786", + "type": "gene", + "text": "Atrial fibrillation and the autonomic nervous system", + "entities": [] + }, + { + "id": "4787", + "type": "gene", + "text": "Therefore , use of presaturation is recommended for myocardial motion studies using cine PC velocity data .", + "entities": [] + }, + { + "id": "4788", + "type": "gene", + "text": "Groups of male and female Fischer 344 rats , B6C3F1 mice , and Hartley guinea pigs were exposed once for 6 hr to mean concentrations of 10 . 5 , 5 . 4 , 2 . 4 , 1 . 0 , or 0 ( control ) ppm of methyl isocyanate ( MIC ) vapor .", + "entities": [] + }, + { + "id": "4789", + "type": "gene", + "text": "In 7 of 9 cases , the enhancer is fused to the c - myc bearing sequences of chromosome 8 .", + "entities": [ + "c - myc bearing sequences" + ] + }, + { + "id": "4790", + "type": "gene", + "text": "Cerebrospinal fluid transferrin II studies in ischemic disorders of the central nervous system .", + "entities": [ + "transferrin II" + ] + }, + { + "id": "4791", + "type": "gene", + "text": "All control persons had a normal reaction to DNFB .", + "entities": [] + }, + { + "id": "4792", + "type": "gene", + "text": "In addition to the signals obtained by ligation of the TCR , T cells need additional , co - stimulatory signals to be activated .", + "entities": [ + "TCR" + ] + }, + { + "id": "4793", + "type": "gene", + "text": "To determine if signing , when established , would compete with SIB when both were reinforced , extinction was then withdrawn .", + "entities": [] + }, + { + "id": "4794", + "type": "gene", + "text": "After two successive rounds of selection by focus formation assay , a transforming ribozyme ( Rz007 ) was identified .", + "entities": [ + "Rz007" + ] + }, + { + "id": "4795", + "type": "gene", + "text": "Dry matter intake , apparent nutrient digestibilities , serum chemistry profiles , sphingolipid concentrations , and persistency of FB1 in tissues were evaluated .", + "entities": [] + }, + { + "id": "4796", + "type": "gene", + "text": "This 300 bp 5 ' - upstream sequence of K3 keratin gene , which can function in vitro as a keratinocyte - specific promoter , contains two clusters of partially overlapping motifs , one with an NFkB consensus sequence and another with a GC box .", + "entities": [ + "K3 keratin gene", + "NFkB" + ] + }, + { + "id": "4797", + "type": "gene", + "text": "Anamnestic data were obtained from case history , smoking habits were not known in collective A and C .", + "entities": [] + }, + { + "id": "4798", + "type": "gene", + "text": "Strontium - 90 was inject i . v . into pregnant rats on day 18 post conception ( p . c . ) .", + "entities": [] + }, + { + "id": "4799", + "type": "gene", + "text": "The plasma half - life of slow disposition phase t1 / 2 beta , increases from 0 . 26 hour in rabbits with normal renal function to 5 . 41 hours in rabbits with severe renal impairment .", + "entities": [] + }, + { + "id": "4800", + "type": "gene", + "text": "Analysis of one cDNA revealed an unusual splicing event involving EZH1 and a tandemly linked gene GPR2 and suggests a potential mechanism for modifying the EZH1 protein in the conserved C - terminal domain .", + "entities": [ + "EZH1", + "GPR2", + "EZH1 protein" + ] + }, + { + "id": "4801", + "type": "gene", + "text": "Northern blot analysis demonstrated the ubiquitous expression of 2 . 9 kb and 3 .", + "entities": [] + }, + { + "id": "4802", + "type": "gene", + "text": "The segmental and regional projections of the sciatic , tibial and common peroneal nerves to the substantia gelatinosa of the spinal cord in rats - - an experimental study by means of an acid phosphatase ( ACP ) method .", + "entities": [ + "acid phosphatase", + "ACP" + ] + }, + { + "id": "4803", + "type": "gene", + "text": "Insulin - like growth factor - I induces bcl - 2 promoter through the transcription factor cAMP - response element - binding protein .", + "entities": [ + "Insulin - like growth factor - I", + "bcl - 2 promoter", + "cAMP - response element - binding protein" + ] + }, + { + "id": "4804", + "type": "gene", + "text": "The p34 . 8 gene has a strong codon usage bias which is strikingly different from that of the polyhedrin gene .", + "entities": [ + "p34 . 8 gene", + "polyhedrin gene" + ] + }, + { + "id": "4805", + "type": "gene", + "text": "In the studies reported here , the 5 ' - flanking region of the human gp130 gene was isolated and the transcription initiation sites were mapped .", + "entities": [ + "human gp130 gene" + ] + }, + { + "id": "4806", + "type": "gene", + "text": "Sequence analysis indicates that RBP21 shares homology with other retinoblastoma - binding proteins in the pRb - binding motif LxCxE at the C - terminal region .", + "entities": [ + "RBP21", + "retinoblastoma - binding proteins", + "pRb - binding motif" + ] + }, + { + "id": "4807", + "type": "gene", + "text": "The promoter mutation is complemented in trans by E1A products of the heterologous helper adenovirus type 5 ( Ad5 ) .", + "entities": [ + "E1A" + ] + }, + { + "id": "4808", + "type": "gene", + "text": "In this report , almost 6 kb of DNA sequence is presented , including 1251 bp 5 ' to the gene , over 4 kb of exon and exon - intron junctions , and 583 bp 3 ' to the gene .", + "entities": [] + }, + { + "id": "4809", + "type": "gene", + "text": "Delayed or paradoxically emptying regions of the left ventricle were detected by a relatively new nuclear technique - - phase imaging .", + "entities": [] + }, + { + "id": "4810", + "type": "gene", + "text": "The potentially SLE - inducing drugs are reviewed .", + "entities": [] + }, + { + "id": "4811", + "type": "gene", + "text": "However , the relative positions of the VV genes ( genus Orthopoxvirus ) are different than those of the corresponding ORFs in SFV ( genus Leporipoxvirus ) , indicating complex rearrangements of DNA in the genome of one or both of these viruses subsequent to their divergence from a common ancestor .", + "entities": [] + }, + { + "id": "4812", + "type": "gene", + "text": "Expression of the proapoptotic protein Bax under the control of a GAL10 promoter in Saccharomyces cerevisiae resulted in galactose - inducible cell death .", + "entities": [ + "proapoptotic protein Bax", + "GAL10 promoter" + ] + }, + { + "id": "4813", + "type": "gene", + "text": "Accurate evaluation of the treatment results in unresectable lung cancer patients must take the strong prognostic factors into account .", + "entities": [] + }, + { + "id": "4814", + "type": "gene", + "text": "Body fat distribution was determined by abdominal computed tomography .", + "entities": [] + }, + { + "id": "4815", + "type": "gene", + "text": "Grasso , and A .", + "entities": [] + }, + { + "id": "4816", + "type": "gene", + "text": "The mean plasma sodium concentration which was 135 . 95 ( + / - SD 4 . 14 ) mEq / kg before diuretic treatment was significantly decreased during treatment to 129 . 19 ( + / - SD 2 . 77 ) mEq / kg , P less than 0 . 001 .", + "entities": [] + }, + { + "id": "4817", + "type": "gene", + "text": "HL 02 type oculomotor stimulator .", + "entities": [] + }, + { + "id": "4818", + "type": "gene", + "text": "Several cDNAs corresponding to the human PWP2 gene were identified and partially sequenced .", + "entities": [ + "human PWP2 gene" + ] + }, + { + "id": "4819", + "type": "gene", + "text": "After clofelin administration the autoregulation borders shifted to the right i . e . towards higher AP levels .", + "entities": [] + }, + { + "id": "4820", + "type": "gene", + "text": "Their studies have revealed a considerable increase of CSF AP activity in purulent meningitides whereas in serous meningitides it grows negligibly .", + "entities": [ + "CSF AP" + ] + }, + { + "id": "4821", + "type": "gene", + "text": "The hepatocyte nuclear factor - 3 ( HNF - 3 ) / forkhead ( fkh ) proteins consist of an extensive family of tissue - specific and developmental gene regulators which share homology within the winged helix DNA binding motif .", + "entities": [ + "hepatocyte nuclear factor - 3", + "HNF - 3", + "forkhead", + "fkh" + ] + }, + { + "id": "4822", + "type": "gene", + "text": "The solution structure of the adduct derived from the covalent bonding of the fjord region ( + ) - ( 11S , 12R , 13R , 14S ) stereoisomer of anti - 11 , 12 - dihydroxy - 13 , 14 - epoxy - 11 , 12 , 13 , 14 - tetrahydrobenzo [ g ] chrysene , ( + ) - anti - B [ g ] CDE , to the exocyclic N ( 6 ) amino group of the adenine residue dA6 , ( designated ( + ) - trans - anti - ( B [ g ] C ) dA6 ) , positioned opposite a thymine residue dT17 in the DNA sequence context d ( C1 - T2 - C3 - T4 - C5 - ( B [ g ] C ) A6 - C7 - T8 - T9 - C10 - C11 ) .", + "entities": [] + }, + { + "id": "4823", + "type": "gene", + "text": "d ( G12 - G13 - A14 - A15 - G16 - T17 - G18 - A19 - G20 + + + - A21 - G22 ) ( designated ( B [ g ] C ) dA . dT 11 - mer duplex ) , has been studied using structural information derived from NMR data in combination with molecular dynamics ( MD ) calculations .", + "entities": [] + }, + { + "id": "4824", + "type": "gene", + "text": "Atomic absorption spectrophotometry applied to bacterially expressed E1A proteins revealed that the 289 - amino acid protein binds one zinc ion , whereas the 243 - amino acid protein binds no zinc .", + "entities": [ + "E1A proteins" + ] + }, + { + "id": "4825", + "type": "gene", + "text": "Among 82 superficial lesions 34 were classified as showing CR and another 23 as showing PR , with a response rate of 69 . 5 % .", + "entities": [] + }, + { + "id": "4826", + "type": "gene", + "text": "Analysis of the 5 ' end of the mouse Elavl1 ( mHuA ) gene reveals a transcriptional regulatory element and evidence for conserved genomic organization .", + "entities": [ + "mouse Elavl1", + "mHuA" + ] + }, + { + "id": "4827", + "type": "gene", + "text": "mHuA ( Elavl1 ) belongs to a highly conserved family of genes encoding RNA - binding proteins and has been linked to cell growth and proliferation through its regulation of mRNA stability .", + "entities": [ + "mHuA", + "Elavl1" + ] + }, + { + "id": "4828", + "type": "gene", + "text": "The results also imply that the absence of perforin expression in non - cytotoxic cells may be due to the suppression of the induction of the killer - cell - specific trans - acting factor NF - P2 .", + "entities": [ + "perforin", + "NF - P2" + ] + }, + { + "id": "4829", + "type": "gene", + "text": "Cloning and sequencing revealed that dMax contains a deletion spanning the basic region and helix 1 and the loop of the helix - loop - helix region , presumably as a result of alternative splicing of max RNA .", + "entities": [ + "dMax", + "max RNA" + ] + }, + { + "id": "4830", + "type": "gene", + "text": "Intron 1 is 6 . 5 kb long , and the minimal sizes of introns 2 and 3 are estimated to be 32 kb each .", + "entities": [] + }, + { + "id": "4831", + "type": "gene", + "text": "It may also be suggested that particular care should be taken when such a trans - dominant Rev mutant is considered to be used as a genetic therapy against HIV - I infection , in individuals infected with both HIV - I and HTLV - 1 .", + "entities": [ + "Rev mutant" + ] + }, + { + "id": "4832", + "type": "gene", + "text": "Molecular cloning of the cDNA for the human U2 snRNA - specific A ' protein .", + "entities": [ + "human U2 snRNA - specific A ' protein" + ] + }, + { + "id": "4833", + "type": "gene", + "text": "Transcription readthrough into the inverted repeats has little effect on this event .", + "entities": [] + }, + { + "id": "4834", + "type": "gene", + "text": "An ASSEMBLER routine for on - line graphic display and averaging of data acquired on a personal microcomputer .", + "entities": [] + }, + { + "id": "4835", + "type": "gene", + "text": "The human RAD30B and mouse Rad30b mRNA transcripts , like many repair proteins , are highly expressed in the testis .", + "entities": [ + "human RAD30B", + "mouse Rad30b mRNA transcripts" + ] + }, + { + "id": "4836", + "type": "gene", + "text": "The experiment included 6 male and 4 female healthy subjects who , during a 24 - hour stay in the respiration chambers , performed , in the morning and afternoon , 15 min cycling with the total work of 6 , 750 kg m .", + "entities": [] + }, + { + "id": "4837", + "type": "gene", + "text": "Pronounced microangiopathy characterized by avascular fields , enlarged and tortuous capillaries and increased transcapillary diffusion of sodium fluorescein , was clearly demonstrable in the area of the nodules .", + "entities": [] + }, + { + "id": "4838", + "type": "gene", + "text": "Amino acid sequence comparisons of the E74A protein reveal a highly conserved C - terminal region that is rich in basic amino acid residues and which has been proposed to possess sequence - specific DNA binding activity .", + "entities": [ + "E74A protein" + ] + }, + { + "id": "4839", + "type": "gene", + "text": "Secondary pancreatic involvement of mycosis fungoides detected by a clinically palpable mass .", + "entities": [] + }, + { + "id": "4840", + "type": "gene", + "text": "EM analysis demonstrated that only one Rep - DNA complex was formed on ch - 19 target DNA .", + "entities": [ + "Rep - DNA complex" + ] + }, + { + "id": "4841", + "type": "gene", + "text": "Two such genes , designated hsiggll150 and hsiggll295 , were cloned and sequenced from genomic DNA .", + "entities": [ + "hsiggll150", + "hsiggll295" + ] + }, + { + "id": "4842", + "type": "gene", + "text": "Induction of CD86 expression by stimulation of U937 cells with IFN - gamma revealed the presence of two functional GAS ( gamma - interferon activation site ) elements .", + "entities": [ + "CD86", + "IFN - gamma", + "GAS", + "gamma - interferon activation site" + ] + }, + { + "id": "4843", + "type": "gene", + "text": "Residual amphotericin B was detected in the feces of the mice only while they were receiving the 0 . 3 mg / ml dose level .", + "entities": [] + }, + { + "id": "4844", + "type": "gene", + "text": "In addition , we find that E2F - 1 can cause apoptosis in p53 - / - tumour cells and further p300 , which also functions as a co - activator for the E2F / DP heterodimer , enhances the apoptotic activity of E2F - 1 .", + "entities": [ + "E2F - 1", + "p53 - / -", + "p300", + "E2F", + "DP", + "E2F - 1" + ] + }, + { + "id": "4845", + "type": "gene", + "text": "Previously , we showed that SNF2 , SNF5 , and SNF6 function interdependently in transcriptional activation , possibly forming a heteromeric complex .", + "entities": [ + "SNF2", + "SNF5", + "SNF6" + ] + }, + { + "id": "4846", + "type": "gene", + "text": "Intermediate levels of gene activity were observed for TnI enhancers containing E - boxes derived from the MCK left E - box site or from the Ig kappa E2 E - box .", + "entities": [ + "TnI enhancers", + "MCK left E - box site", + "Ig kappa E2 E - box" + ] + }, + { + "id": "4847", + "type": "gene", + "text": "Molecular cloning and characterization of OsPSK , a gene encoding a precursor for phytosulfokine - alpha , required for rice cell proliferation .", + "entities": [ + "OsPSK", + "phytosulfokine - alpha" + ] + }, + { + "id": "4848", + "type": "gene", + "text": "There was evidence of attenuated regression slopes relating recalled to observed portion sizes for 4 of the 10 food groups ; adjusted r2 values for the recalled portion sizes ranged from 0 . 02 to 0 . 94 .", + "entities": [] + }, + { + "id": "4849", + "type": "gene", + "text": "A promoter sequence ( Goldberg - Hogness or TATA box ) is situated 28 base pairs upstream from the point of initiation of transcription which was found by S1 nuclease mapping and by oligonucleotide - primed reverse transcription of rat PTH mRNA .", + "entities": [ + "S1 nuclease", + "rat PTH mRNA" + ] + }, + { + "id": "4850", + "type": "gene", + "text": "A single - case experimental ABAB multiple baseline design was employed to test for treatment effectiveness .", + "entities": [] + }, + { + "id": "4851", + "type": "gene", + "text": "Replacement of the wild - type 5 ' - regulatory region with either of the mutants ' cis - acting regulatory element resulted in the anaerobic expression of active Mn - superoxide dismutase .", + "entities": [ + "active Mn - superoxide dismutase" + ] + }, + { + "id": "4852", + "type": "gene", + "text": "We determined whether a single injection of slow - release estradiol - 17beta ( SRE2 ) would induce pseudopregnancy in gilts and whether PGF2alpha would regress the corpora lutea ( CL ) of pseudopregnancy .", + "entities": [] + }, + { + "id": "4853", + "type": "gene", + "text": "The state of the liver in generalized forms of meningococcal infection", + "entities": [] + }, + { + "id": "4854", + "type": "gene", + "text": "By analyzing 5 ' - deletion insulin promoter - reporter constructs in transient transfections of clonal INS - 1 beta - cells , we located activating Hh - responsive regions within the rat insulin I promoter that include the glucose - response elements Far ( E2 ) and Flat ( A2 / A3 ) .", + "entities": [ + "insulin promoter - reporter constructs", + "INS - 1 beta", + "Hh", + "rat insulin I promoter" + ] + }, + { + "id": "4855", + "type": "gene", + "text": "Articles addressing valvular heart disease or heart failure secondary to acute myocardial infarction or Chagas ' disease were excluded .", + "entities": [] + }, + { + "id": "4856", + "type": "gene", + "text": "During the dose - finding , two patients were temporarily withdrawn from medication and one patient was excluded because of elevated levels of liver enzymes .", + "entities": [] + }, + { + "id": "4857", + "type": "gene", + "text": "The Sp1 region , however , is converted to a functionally strong TRE by the viral tat factor .", + "entities": [ + "Sp1 region", + "viral tat factor" + ] + }, + { + "id": "4858", + "type": "gene", + "text": "Thus , NART - R performance may not be a valid estimate of baseline IQ for patients with neurologic disorders with suspected language impairment .", + "entities": [] + }, + { + "id": "4859", + "type": "gene", + "text": "Type 2 deiodinase ( D2 ) catalyzes the 5 ' - deiodination of thyroxine to form 3 , 5 , 3 ' - triiodothyronine .", + "entities": [ + "Type 2 deiodinase", + "D2" + ] + }, + { + "id": "4860", + "type": "gene", + "text": "A mutation linked to the SOC1 gene , previously defined by recessive mutations that suppress cbp1 ts alleles and stabilize many mitochondrial mRNAs , was also isolated .", + "entities": [ + "SOC1 gene", + "cbp1 ts alleles" + ] + }, + { + "id": "4861", + "type": "gene", + "text": "However , multiple alanine substitutions or proline ( helix - destabilizing ) substitutions disrupted both oligomerization and transport of GP64 EFP .", + "entities": [ + "GP64 EFP" + ] + }, + { + "id": "4862", + "type": "gene", + "text": "It is useful as an adjunct to mammography in those patients with radiographically dense breasts for the characterization of palpable masses .", + "entities": [] + }, + { + "id": "4863", + "type": "gene", + "text": "Sulfhydryl titration with iodoacetamide , monitored by quantitating the residual thiols after reaction with a maleimide derivative of biotin , revealed a striking difference in the apparent pK ( a ) values of the cysteines at the two splice junctions .", + "entities": [] + }, + { + "id": "4864", + "type": "gene", + "text": "When phencyclidine was administered alone , overall response rate decreased and percent errors increased with increasing doses .", + "entities": [] + }, + { + "id": "4865", + "type": "gene", + "text": "Constitutive function of a positively regulated promoter reveals new sequences essential for activity .", + "entities": [] + }, + { + "id": "4866", + "type": "gene", + "text": "Furthermore , ICER negatively autoregulates the alternative promoter , thus generating a feedback loop .", + "entities": [ + "ICER" + ] + }, + { + "id": "4867", + "type": "gene", + "text": "Furthermore , bone marrow - derived macrophages from LAT - deficient mice displayed reduced phagocytic efficiency in comparison to the macrophages from wild - type mice .", + "entities": [ + "LAT" + ] + }, + { + "id": "4868", + "type": "gene", + "text": "Increased p53 activity induced by OP is not due to elevated p53 mRNA nor to protein levels .", + "entities": [ + "p53", + "p53 mRNA" + ] + }, + { + "id": "4869", + "type": "gene", + "text": "MBI and MMBI showed similar Cmax values , but the former disappeared slower in the serum than the latter and resulted in its larger AUC values .", + "entities": [] + }, + { + "id": "4870", + "type": "gene", + "text": "The sequence was determined for a 4024 - base pair ( bp ) segment that extends from 149 bp 5 ' to the cap site of alpha 1 to 207 bp 3 ' to psi alpha .", + "entities": [ + "alpha 1", + "psi alpha" + ] + }, + { + "id": "4871", + "type": "gene", + "text": "A study of the comparative efficacy of diflucortolone valerate 0 . 3 % ointment and clobetasol propionate 0 . 05 % ointment .", + "entities": [] + }, + { + "id": "4872", + "type": "gene", + "text": "Therefore , recombinant human Ads that express noninfectious HIV or other microbial proteins are attractive vaccine candidates .", + "entities": [] + }, + { + "id": "4873", + "type": "gene", + "text": "Utero - placental blood flow and the effect of beta 2 - adrenoceptor stimulating drugs .", + "entities": [ + "beta 2 - adrenoceptor" + ] + }, + { + "id": "4874", + "type": "gene", + "text": "Deletion and site - directed mutagenesis localized a novel SF - 1 regulatory element ( TCA GGGCCA ; - 137 to - 129 ) adjacent to a variant cAMP - response element ( CRE ; - 120 to - 114 ) .", + "entities": [ + "SF - 1 regulatory element" + ] + }, + { + "id": "4875", + "type": "gene", + "text": "The full length cDNA sequence of a Type I transforming growth factor - beta ( TGF - beta ) receptor has been isolated from the filarial parasitic nematode Brugia pahangi .", + "entities": [ + "Type I transforming growth factor - beta ( TGF - beta ) receptor" + ] + }, + { + "id": "4876", + "type": "gene", + "text": "In 8 healthy volunteers there were no significant differences in AUC , peak plasma concentrations or time to peak concentration when OXC was administered either with or without ERY .", + "entities": [] + }, + { + "id": "4877", + "type": "gene", + "text": "Diallylnitrosamine ( DAN ) , one of the few nitrosamines tested thus far that has not induced neoplasms in rats , caused a high incidence of respiratory tract tumors in Syrian golden hamsters treated sc with single or weekly doses of the compound .", + "entities": [] + }, + { + "id": "4878", + "type": "gene", + "text": "Unlike P135gag - myb - ets and the Mr 75 , 000 translation product of c - myb ( P75c - myb ) , which are nuclear proteins , P54c - ets was found to be predominantly cytoplasmic .", + "entities": [ + "P135gag", + "myb", + "ets", + "c - myb", + "P75c - myb", + "P54c - ets" + ] + }, + { + "id": "4879", + "type": "gene", + "text": "Two of the three groups were administered dauricine , as a new calcium channel blocker , and verapamil , as a generally recognized calcium channel blocker , respectively , from 15 minutes pre - bypass to the end of the bypass procedure ( a period of 95 minutes ) .", + "entities": [] + }, + { + "id": "4880", + "type": "gene", + "text": "In particular , 71 and 69 % amino acid sequence similarities were identified with hsp70 of Escherichia coli and Bacillus megaterium , respectively .", + "entities": [ + "hsp70 of Escherichia coli and Bacillus megaterium" + ] + }, + { + "id": "4881", + "type": "gene", + "text": "Whole blood serotonin levels were investigated in a control group ( n = 35 ) and in a group of chronic renal failure patients ( n = 127 ) on various treatment regimen i . e . conservative treatment ( n = 39 ) , maintenance haemodialysis ( n = 35 ) and after renal transplantation ( n = 53 ) .", + "entities": [] + }, + { + "id": "4882", + "type": "gene", + "text": "The results indicate that rep strongly enhances the function of negative regulatory elements of the LTR .", + "entities": [ + "rep" + ] + }, + { + "id": "4883", + "type": "gene", + "text": "These differences involve specific hydrogen - bonding interactions between the protein and DNA , including guanine N7 sites in the major groove of DNA , and alterations in DNA phosphodiester conformation induced by protein binding .", + "entities": [] + }, + { + "id": "4884", + "type": "gene", + "text": "Effect of immune lymphocytes and of rabbit - anti - lymphocyte globulin ( RAMLG ) on infected macrophages exposed to increased incubation temperature in vitro .", + "entities": [ + "rabbit - anti - lymphocyte globulin", + "RAMLG" + ] + }, + { + "id": "4885", + "type": "gene", + "text": "Neurons were held at - 67 mV to equate voltage - dependent effects .", + "entities": [] + }, + { + "id": "4886", + "type": "gene", + "text": "However , when domain I and domain II were linked on the same plasmid , high levels of replication were observed .", + "entities": [] + }, + { + "id": "4887", + "type": "gene", + "text": "The gene encodes an ATP - binding cassette , ABC transporter .", + "entities": [ + "ATP - binding cassette", + "ABC transporter" + ] + }, + { + "id": "4888", + "type": "gene", + "text": "Taken together , our data suggest that prostate carcinomas with the Ras / MAPK pathway activation might have a selective growth advantage by autocrine TGF - beta1 production .", + "entities": [ + "Ras", + "MAPK", + "TGF - beta1" + ] + }, + { + "id": "4889", + "type": "gene", + "text": "Homograft response and hemagglutinin production by sensitized thymectomized irradiated adult mice .", + "entities": [ + "hemagglutinin" + ] + }, + { + "id": "4890", + "type": "gene", + "text": "In order to quantify these effects , tests were conducted in the NASA MSFC Neutral Buoyancy Simulator , in the NASA KC - 135 in parabolic flight , and in space with the EASE program during the Shuttle Atlantis mission 61 - B .", + "entities": [] + }, + { + "id": "4891", + "type": "gene", + "text": "These results suggested that the GG motifs contributed to the cell - specific transcription of the human insulin gene in association with the binding of the sequence - specific nuclear factor .", + "entities": [ + "human insulin gene" + ] + }, + { + "id": "4892", + "type": "gene", + "text": "Molecular cloning and characterization of a cDNA , CHEMR1 , encoding a chemokine receptor with a homology to the human C - C chemokine receptor , CCR - 4 .", + "entities": [ + "CHEMR1", + "human C - C chemokine receptor", + "CCR - 4" + ] + }, + { + "id": "4893", + "type": "gene", + "text": "This phenomenon may be regarded as a variant of selective individual cell death , currently referred to as apoptosis , which has not been previously reported in a case of embryonal rhabdomyosarcoma .", + "entities": [] + }, + { + "id": "4894", + "type": "gene", + "text": "Rheumatoid factor and antinuclear antibody tests were frequently positive , and reactions to gold therapy were more frequent than in other rheumatoid populations .", + "entities": [ + "Rheumatoid factor" + ] + }, + { + "id": "4895", + "type": "gene", + "text": "Specifically , they were performed to determine whether detection of envelope phase disparity was consistent with processing within a single channel in which the AM tones were simply added .", + "entities": [] + }, + { + "id": "4896", + "type": "gene", + "text": "Ten males performed both test conditions and oxygen uptake VO2 , heart rate , minute ventilation VE , perceived exertion and spinal shrinkage were recorded .", + "entities": [] + }, + { + "id": "4897", + "type": "gene", + "text": "By sequence comparison , 42 blocks of homology are defined in the 5 ' - terminal region , of which 36 appear in the CpG island and contain numerous conserved CpG dinucleotides .", + "entities": [] + }, + { + "id": "4898", + "type": "gene", + "text": "Characterization of polymorphic TNRs in novel and even known genes expressed in human spinal cord is likely to help in the identification of new candidates for genes involved in neurodegenerative disorders .", + "entities": [] + }, + { + "id": "4899", + "type": "gene", + "text": "Tumor stages were IIB ( T3 N0 ) in 52 % , IIIA in 15 % , and IIIB in 27 % of patients .", + "entities": [] + }, + { + "id": "4900", + "type": "gene", + "text": "All patients had abnormal von Willebrand factor ( vWF ) fragmentation as reflected by decreased high molecular weight and increased low molecular weight vWF multimers in the circulation .", + "entities": [ + "von Willebrand factor", + "vWF", + "vWF multimers" + ] + }, + { + "id": "4901", + "type": "gene", + "text": "Indeed , A - MuLV pseudotyped with some viruses , such as the Moloney MuLV , has been shown to be highly lymphogenic , whereas A - MuLV pseudotyped with other viruses , such as the BALB / c endogenous N - tropic MuLV , has been shown to be devoid of lymphogenic potential ( N .", + "entities": [] + }, + { + "id": "4902", + "type": "gene", + "text": "The two cysteine residues located in this additional region may be involved in the formation of a disulfide bridge associated with the activation process of the catalytic activity .", + "entities": [] + }, + { + "id": "4903", + "type": "gene", + "text": "Blood levels of melatonin , serotonin , cortisol , and prolactin in relation to the circadian rhythm of platelet serotonin uptake .", + "entities": [ + "prolactin" + ] + }, + { + "id": "4904", + "type": "gene", + "text": "Raes , P .", + "entities": [] + }, + { + "id": "4905", + "type": "gene", + "text": "One unit encodes traA , traF , and traB , while the second encodes traC , traD , and traG .", + "entities": [ + "traA", + "traF", + "traB", + "traC", + "traD", + "traG" + ] + }, + { + "id": "4906", + "type": "gene", + "text": "Thus , the B - S mutant does not mimic efficiently the chloroplastic GAPDHs , and long - range and / or second - layer effects , not easily predictable from visual inspection of three - dimensional structures , need to be taken into account for designing a true \" chloroplastic - like \" mutant of cytosolic GAPDH .", + "entities": [ + "chloroplastic GAPDHs", + "cytosolic GAPDH" + ] + }, + { + "id": "4907", + "type": "gene", + "text": "Max : functional domains and interaction with c - Myc .", + "entities": [ + "Max", + "c - Myc" + ] + }, + { + "id": "4908", + "type": "gene", + "text": "In humans , four AMP deaminase variants , termed M ( muscle ) , L ( liver ) , E1 , and E2 ( erythrocyte ) can be distinguished by a variety of biochemical and immunological criteria .", + "entities": [ + "AMP deaminase variants", + "M", + "L", + "E1", + "E2" + ] + }, + { + "id": "4909", + "type": "gene", + "text": "To assess the function ( s ) of E74 during metamorphosis , we have isolated and characterized recessive loss - of - function mutations specific to each transcription unit .", + "entities": [ + "E74" + ] + }, + { + "id": "4910", + "type": "gene", + "text": "The O2 deficit was not related to blood lactate during submaximal exercise , muscle enzyme activity ( citrate synthase , 3 - hydroxyacyl - CoA - dehydrogenase , lactate dehydrogenase ) , number of muscle capillaries , % ST fibres or muscle buffer capacity .", + "entities": [ + "citrate synthase", + "3 - hydroxyacyl - CoA - dehydrogenase", + "lactate dehydrogenase" + ] + }, + { + "id": "4911", + "type": "gene", + "text": "This study examined the role of cholesteryl ester transfer ( CET ) , cholesteryl ester transfer protein ( CETP ) activity , and phospholipid transfer protein ( PLTP ) activity in the increased prevalence of coronary artery calcification ( CAC ) in diabetic subjects compared with nondiabetic subjects and in the loss of the sex difference in CAC in diabetes .", + "entities": [ + "cholesteryl ester transfer protein", + "CETP", + "phospholipid transfer protein", + "PLTP" + ] + }, + { + "id": "4912", + "type": "gene", + "text": "Whether or not there are sequences conferring cAMP responsiveness which are common both to P - 450scc and the other steroidogenic P - 450 genes remains to be established .", + "entities": [ + "P - 450scc", + "P - 450 genes" + ] + }, + { + "id": "4913", + "type": "gene", + "text": "Decreased serum ceruloplasmin and copper levels in cervical dystonia .", + "entities": [ + "serum ceruloplasmin" + ] + }, + { + "id": "4914", + "type": "gene", + "text": "Here , we describe directional chromosome walking studies starting from D8S260 as well as D8S285 .", + "entities": [ + "D8S260", + "D8S285" + ] + }, + { + "id": "4915", + "type": "gene", + "text": "Transcription factors of the Stat family are controlled by protein kinases .", + "entities": [ + "Stat family" + ] + }, + { + "id": "4916", + "type": "gene", + "text": "Exogenous LHRH is also known to facilitate mating behavior in several species .", + "entities": [ + "LHRH" + ] + }, + { + "id": "4917", + "type": "gene", + "text": "From the Icelandic Red Cross activities", + "entities": [] + }, + { + "id": "4918", + "type": "gene", + "text": "The obvious functional necessity for editing in kinetoplastid mitochondria is the formation of translatable mRNAs .", + "entities": [] + }, + { + "id": "4919", + "type": "gene", + "text": "Chagas ' disease , visceral leishmaniasis , anti - nuclear factor , schistosomiasis , rheumatoid factor and normal controls .", + "entities": [ + "anti - nuclear factor", + "rheumatoid factor" + ] + }, + { + "id": "4920", + "type": "gene", + "text": "y .", + "entities": [] + }, + { + "id": "4921", + "type": "gene", + "text": "( 5 ) An increase in leukocyte - counts occurred on the administration of serum obtained from rabbit during phase - 2 .", + "entities": [] + }, + { + "id": "4922", + "type": "gene", + "text": "Computer assisted mapping in quantitative analysis of cerebral positron emission tomograms .", + "entities": [] + }, + { + "id": "4923", + "type": "gene", + "text": "We have isolated and analyzed human CTCF cDNA clones and show here that the ubiquitously expressed 11 - zinc - finger factor CTCF is an exceptionally highly conserved protein displaying 93 % identity between avian and human amino acid sequences .", + "entities": [ + "human CTCF cDNA", + "11 - zinc - finger factor CTCF" + ] + }, + { + "id": "4924", + "type": "gene", + "text": "To avoid complications , accurate quantitative analysis of NO and NO2 is necessary during this therapy .", + "entities": [] + }, + { + "id": "4925", + "type": "gene", + "text": "Specimens were assayed for alpha - fetoprotein , unconjugated estriol , free alpha hCG , and total hCG .", + "entities": [ + "alpha - fetoprotein", + "alpha hCG", + "hCG" + ] + }, + { + "id": "4926", + "type": "gene", + "text": "Anesthesiologists often use more than one drug in a patient to achieve a target response , such as a desired blood pressure .", + "entities": [] + }, + { + "id": "4927", + "type": "gene", + "text": "However , the history of acute severe complications from otitis media revealed a higher frequency in those individuals with alpha 1 - antitrypsin deficiency as compared to normals .", + "entities": [ + "alpha 1 - antitrypsin" + ] + }, + { + "id": "4928", + "type": "gene", + "text": "MR imaging of traumatic head injuries using FLAIR technique", + "entities": [] + }, + { + "id": "4929", + "type": "gene", + "text": "In this study , we report the isolation and characterization of the entire rat GSTA3 ( rGST Yc1 ) subunit gene .", + "entities": [ + "rat GSTA3", + "rGST Yc1" + ] + }, + { + "id": "4930", + "type": "gene", + "text": "These indications of deregulated signalling in the absence of tyrosine 118 were substantiated by sustained activation of STAT3 .", + "entities": [ + "STAT3" + ] + }, + { + "id": "4931", + "type": "gene", + "text": "DNA - STAT complexes were detected in all Bcr / Abl - transformed cell lines and they were supershifted by antibodies against STAT1 and STAT5 .", + "entities": [ + "DNA - STAT complexes", + "Bcr", + "Abl", + "STAT1", + "STAT5" + ] + }, + { + "id": "4932", + "type": "gene", + "text": "A double - blind trial of half - strength Polybactrin Soluble GU bladder irrigation in cystoscopy .", + "entities": [] + }, + { + "id": "4933", + "type": "gene", + "text": "Abnormal technetium Tc 99m medronate scans in patients with previously undiagnosed polyarthralgias suggested inflammatory arthropathy and influenced management decisions with favorable therapeutic outcomes .", + "entities": [] + }, + { + "id": "4934", + "type": "gene", + "text": "A new method for the quantitative analysis of sleep spindles during continuous overnight EEG recordings .", + "entities": [] + }, + { + "id": "4935", + "type": "gene", + "text": "To examine the biochemical basis of the end joining , nuclear extracts were prepared from a wide variety of mammalian cell lines and tested for their ability to join test plasmid substrates .", + "entities": [] + }, + { + "id": "4936", + "type": "gene", + "text": "In order to investigate to what extent this interaction might contribute to tumor induction by the virus , we have introduced two different point mutations within the putative pRb - binding sequence of large T antigen , and as a preliminary to in vivo experiments we have studied their effects in vitro on some biological activities relevant to tumor induction .", + "entities": [ + "pRb - binding sequence", + "large T antigen" + ] + }, + { + "id": "4937", + "type": "gene", + "text": "Eighty patients presenting to HGGM with non - Hodgkin ' s lymphomas between 1962 and 1986 , were reviewed .", + "entities": [] + }, + { + "id": "4938", + "type": "gene", + "text": "Transient transfection experiments revealed that Pax - 8 isoforms a and b , but not c and d , strongly stimulate transcription from a promoter containing six copies of a paired - domain recognition sequence .", + "entities": [ + "Pax - 8 isoforms a and b", + "paired - domain recognition sequence" + ] + }, + { + "id": "4939", + "type": "gene", + "text": "Blood eosinophils in patients with Taenia saginata taeniasis .", + "entities": [] + }, + { + "id": "4940", + "type": "gene", + "text": "The linear plasmid pDHL1 from Debaryomyces hansenii encodes a protein highly homologous to the pGKL1 - plasmid DNA polymerase .", + "entities": [ + "pGKL1 - plasmid DNA polymerase" + ] + }, + { + "id": "4941", + "type": "gene", + "text": "RESULTS : The overall FNF for 1992 was 12 . 3 % and was 19 . 1 % , 22 . 2 % , 3 . 8 % and 6 . 1 % per successive quarters in 1992 .", + "entities": [] + }, + { + "id": "4942", + "type": "gene", + "text": "Third , consistent with these data , N - acetylcysteine reduced the stimulatory effect of HGF on stress kinase activities , while p42 / 44 mitogen activated kinase ( MAPK ) was unmodified , suggesting an involvement of c - Jun - N - terminal kinase ( JNK ) and p38 MAPK in HIF - 1 activation .", + "entities": [ + "HGF", + "stress kinase", + "p42 / 44", + "c - Jun - N - terminal kinase", + "JNK", + "p38", + "HIF - 1" + ] + }, + { + "id": "4943", + "type": "gene", + "text": "The site of autophosphorylation is Tyr397 which corresponds to the consensus autophosphorylation site of other Src family tyrosine kinases .", + "entities": [ + "tyrosine kinases" + ] + }, + { + "id": "4944", + "type": "gene", + "text": "C . , Sun , J . , Hsu , M . - Y . , Vallejo - Ramirez , J . , Inouye , S . , and Inouye , M .", + "entities": [] + }, + { + "id": "4945", + "type": "gene", + "text": "Diagnostic value of cerebrospinal fluid immunoglobulin G ( IgG ) in pediatric neurological diseases .", + "entities": [ + "cerebrospinal fluid immunoglobulin G", + "IgG" + ] + }, + { + "id": "4946", + "type": "gene", + "text": "The cellular sequences 5 ' to the viral integration site exhibited 85 to 97 % identity to several sequences belonging to the mouse L1 family of long interspersed repetitive sequences .", + "entities": [ + "mouse L1 family" + ] + }, + { + "id": "4947", + "type": "gene", + "text": "( iv ) Although UCRBP has been previously shown to act as a transcriptional repressor , we show here that UCRBP can also act as a positive transactivator of a reporter driven by UCR elements when used in co - transfection assays .", + "entities": [ + "UCRBP", + "UCRBP" + ] + }, + { + "id": "4948", + "type": "gene", + "text": "Immunologically reactive insulin levels were determined in freely - moving normal rats offered three different test - meals .", + "entities": [ + "insulin" + ] + }, + { + "id": "4949", + "type": "gene", + "text": "There was a gradual increase in the myocyte diameter according to age in the biopsy and autopsy specimens .", + "entities": [] + }, + { + "id": "4950", + "type": "gene", + "text": "In CV - 1 cells , cotransfection of the retinoid and estrogen receptors led to mutual inhibition of the other ' s activity , while an RA - dependent inhibition of ER activity was observed in breast cancer cells .", + "entities": [ + "retinoid and estrogen receptors", + "ER" + ] + }, + { + "id": "4951", + "type": "gene", + "text": "Holliday junction resolvase in Schizosaccharomyces pombe has identical endonuclease activity to the CCE1 homologue YDC2 .", + "entities": [ + "Holliday junction resolvase", + "CCE1", + "YDC2" + ] + }, + { + "id": "4952", + "type": "gene", + "text": "Intact Flag - tagged protein products from all six were produced from genomic expression vectors , although the ORF40 / 41 transcript encoding a primase - helicase component proved to be spliced with a 127 - bp intron .", + "entities": [ + "primase", + "helicase" + ] + }, + { + "id": "4953", + "type": "gene", + "text": "Together with a considerably shortened and interrupted aromatic aa stretch in this region , these differences are discussed in terms of the peculiar affinity of cyanobacterial cytochrome oxidases for acidic c - type cytochromes .", + "entities": [ + "cyanobacterial cytochrome oxidases", + "c - type cytochromes" + ] + }, + { + "id": "4954", + "type": "gene", + "text": "Sequence analysis reveals that the DNA binding domain of ILF has strong homology to the recently described fork head DNA binding domain found in the Drosophila homeotic protein fork head and a family of hepatocyte nuclear factors , HNF - 3 .", + "entities": [ + "ILF", + "fork head DNA binding domain", + "Drosophila homeotic protein fork head", + "hepatocyte nuclear factors", + "HNF - 3" + ] + }, + { + "id": "4955", + "type": "gene", + "text": "RESULTS : Each year , on average 39 % of cases seen in Sardinia are notified ; 646 ( 40 % ) of the 1591 patients notified during the study period were never seen by regional medical centres .", + "entities": [] + }, + { + "id": "4956", + "type": "gene", + "text": "Elevation of the tissues of the face is essentially vertical and acts on the forehead , temporal region , gaze and cheekbones .", + "entities": [] + }, + { + "id": "4957", + "type": "gene", + "text": "Thus , IRF - 7 exhibits functional similarity to IRF - 3 ; however , the preferential expression of IRF - 7 in lymphoid cells ( the cell type that expresses IFNA ) suggests that IRF - 7 may play a critical role in regulating the IFNA gene expression .", + "entities": [ + "IRF - 7", + "IRF - 3", + "IRF - 7", + "IFNA", + "IRF - 7", + "IFNA gene" + ] + }, + { + "id": "4958", + "type": "gene", + "text": "Five out of eight consecutive cases with initial symptoms of a ' midline granuloma ' were identified as malignant histiocytosis ( histiocytic sarcoma ) which within 5 months to 4 years led to generalization and death .", + "entities": [] + }, + { + "id": "4959", + "type": "gene", + "text": "A technique for thermal imaging of the animal and human brain cortex using an infrared optical system is described .", + "entities": [] + }, + { + "id": "4960", + "type": "gene", + "text": "In addition , computer analysis suggests that sequences similar to the A stem element are present within the three AAV promoter regions .", + "entities": [ + "AAV promoter" + ] + }, + { + "id": "4961", + "type": "gene", + "text": "HIV infectiousness and the AIDS epidemic .", + "entities": [] + }, + { + "id": "4962", + "type": "gene", + "text": "Once HIT II is suspected , heparin ( and low - molecular - weight heparins ) should be stopped immediately .", + "entities": [] + }, + { + "id": "4963", + "type": "gene", + "text": "The HMG CoA reductase inhibitors are the most effective cholesterol - lowering agents currently available .", + "entities": [ + "HMG CoA reductase" + ] + }, + { + "id": "4964", + "type": "gene", + "text": "At the same time we obtained easily understandable EEG - information which has never previously been available to us .", + "entities": [] + }, + { + "id": "4965", + "type": "gene", + "text": "Two predominant effects were noted : ( i ) the Xaa residue in the dual phosphorylation motif Thr - Xaa - Tyr as well as the length of L12 influence p38 substrate specificity , and ( ii ) the length of L12 plays a major role in controlling autophosphorylation .", + "entities": [ + "p38" + ] + }, + { + "id": "4966", + "type": "gene", + "text": "Prolonged suspension induced a significant change in the geometric configuration of the femur middiaphysis by increasing the minimum diameter ( 12 % ) without any significant alterations in cortical area , density , mineral , and collagen concentrations .", + "entities": [ + "collagen" + ] + }, + { + "id": "4967", + "type": "gene", + "text": "A method for determining optimal development conditions by summary oxygen consumption", + "entities": [] + }, + { + "id": "4968", + "type": "gene", + "text": "High dosages of D - penicillamine in pulmonary fibroses", + "entities": [] + }, + { + "id": "4969", + "type": "gene", + "text": "Acad .", + "entities": [] + }, + { + "id": "4970", + "type": "gene", + "text": "However , the BCH group showed inferior gross motor performance on the Bruininks - Oseretsky Test of Motor Proficiency ( Bruininks 1978 ) .", + "entities": [] + }, + { + "id": "4971", + "type": "gene", + "text": "We also found an eIF - 4A intronless retroposon which , when compared to the cDNA , contains a single nucleotide difference .", + "entities": [ + "eIF - 4A" + ] + }, + { + "id": "4972", + "type": "gene", + "text": "The results of replicase assays performed with mutant VP2 containing a deletion in its RNA - binding domain suggests that the essential role for VP2 in replication is linked to the protein ' s ability to bind the mRNA template for minus - strand synthesis .", + "entities": [ + "replicase", + "mutant VP2", + "VP2" + ] + }, + { + "id": "4973", + "type": "gene", + "text": "The SH2 and SH3 domains of pp60src direct stable association with tyrosine phosphorylated proteins p130 and p110 .", + "entities": [ + "SH2", + "SH3 domains", + "pp60src", + "p130", + "p110" + ] + }, + { + "id": "4974", + "type": "gene", + "text": "In throttling valves , the aim is to correlate the effect of shear to a parameter related to the inner geometry of the valve and to operating conditions .", + "entities": [] + }, + { + "id": "4975", + "type": "gene", + "text": "Osteosarcoma caused by 3 , 4 - benzopyrene", + "entities": [] + }, + { + "id": "4976", + "type": "gene", + "text": "In this study , a common mechanism has been identified to coordinate the growth - and FC - dependent expression of caveolin .", + "entities": [ + "caveolin" + ] + }, + { + "id": "4977", + "type": "gene", + "text": "Such a change may involve increased mammary utilization of pre - formed long - chain fatty acid and increased metabolism of glucose via glycolysis .", + "entities": [] + }, + { + "id": "4978", + "type": "gene", + "text": "Each immunoprecipitate contained a complex of N1 ( deltaEC ) and CBF1 .", + "entities": [ + "N1 ( deltaEC )", + "CBF1" + ] + }, + { + "id": "4979", + "type": "gene", + "text": "Premature initiation of mitosis in yeast lacking RCC1 or an interacting GTPase .", + "entities": [ + "RCC1", + "GTPase" + ] + }, + { + "id": "4980", + "type": "gene", + "text": "Granisetron , but not saline , abolished vomiting and nausea when given as intervention after this combined emetic regimen .", + "entities": [] + }, + { + "id": "4981", + "type": "gene", + "text": "Compared to those with normal renal functions , these patients were older ( P < or = 0 . 01 ) , had significantly elevated blood pressures ( P < 0 . 01 or P = 0 . 0001 ) , and in the case of Type 1 DM , with a higher body mass index ( P = 0 . 0001 ) and waist - hip ratio ( P < 0 . 01 ) .", + "entities": [] + }, + { + "id": "4982", + "type": "gene", + "text": "We have found a satisfactory reproducibility in vitro ( T1 : 1 . 9 % ; T2 : 6 . 2 % ) , while the reproducibility was less satisfactory in vivo ( T1 : 16 . 4 % ; T2 : 13 . 4 % ) .", + "entities": [] + }, + { + "id": "4983", + "type": "gene", + "text": "We thus conclude that the NFAT RIR plays an essential dual role in DNA recognition and cooperative binding to AP - 1 family transcription factors .", + "entities": [ + "NFAT RIR", + "AP - 1 family transcription factors" + ] + }, + { + "id": "4984", + "type": "gene", + "text": "The prothrombin gene G20210A mutation is not found among Japanese patients with deep vein thrombosis and healthy individuals .", + "entities": [ + "prothrombin gene G20210A mutation" + ] + }, + { + "id": "4985", + "type": "gene", + "text": "Nonteratogenicity in rats of blighted potatoes and compounds contained in them .", + "entities": [] + }, + { + "id": "4986", + "type": "gene", + "text": "This cluster consisted of four apparently unrelated ESTs and two genes , pregnancy - associated plasma protein - A ( PAPP - A ) and a novel gene ( tentatively named EST - YD1 ) .", + "entities": [ + "pregnancy - associated plasma protein - A", + "PAPP - A", + "EST - YD1" + ] + }, + { + "id": "4987", + "type": "gene", + "text": "Although there is little evidence that diet composition plays a clinically important role in the absorption or expenditure of energy , it does appear to play a role in food intake .", + "entities": [] + }, + { + "id": "4988", + "type": "gene", + "text": "The size discrepancy is not due to glycosylation or phosphorylation of Ag35 but may result from a proline - rich sequence which occurs in this polypeptide .", + "entities": [ + "Ag35" + ] + }, + { + "id": "4989", + "type": "gene", + "text": "Thus , chronic hematocrit decrease induced by H or P resulted in a significant fall in blood pressure compared to control ( 201 + / - 3 v 175 + / - 4 , 167 + / - 4 mm Hg , respectively ; P < . 05 ) .", + "entities": [] + }, + { + "id": "4990", + "type": "gene", + "text": "Based on the estimated values of divergence of apobec1 sequences in terms of the numbers of synonymous and non - synonymous suhstitutions per site , we found that apobec1 is a fairly rapidly evolving protein .", + "entities": [ + "apobec1 sequences", + "apobec1" + ] + }, + { + "id": "4991", + "type": "gene", + "text": "The afferents ' phase of response was unmodified by electrical EVS stimulation .", + "entities": [] + }, + { + "id": "4992", + "type": "gene", + "text": "The Dox - A2 locus is within 3 . 4 to 4 . 4 kb of the Df ( 2L ) OD15 breakpoint , placing four of the vital loci within a maximum of 15 . 5 kb .", + "entities": [ + "Dox - A2 locus", + "Df ( 2L ) OD15 breakpoint" + ] + }, + { + "id": "4993", + "type": "gene", + "text": "It is concluded that haloperidol selectively reduced the animal ' s capacity to ' programme non - stimulus directed motor behaviour ' .", + "entities": [] + }, + { + "id": "4994", + "type": "gene", + "text": "These studies demonstrate that both G alpha i genes are dynamically regulated in LLC - PK1 cells by both growth , differentiation , and hormone signals .", + "entities": [ + "G alpha i genes" + ] + }, + { + "id": "4995", + "type": "gene", + "text": "A 2 . 3 - kb full - length cDNA clone of an Atlantic halibut Mx gene was isolated from a liver cDNA library .", + "entities": [ + "Atlantic halibut Mx gene" + ] + }, + { + "id": "4996", + "type": "gene", + "text": "Transient , high - level Ras - expression induces transcriptional activation of p21 mediated by a GC - rich region in p21 promoter - 83 - 54 bp relative to the transcription initiation site containing binding sites for Sp1 - family transcription factors .", + "entities": [ + "Ras", + "p21", + "p21 promoter", + "Sp1 - family transcription factors" + ] + }, + { + "id": "4997", + "type": "gene", + "text": "Normocapnic ( PACO2 = 40 mm Hg ) ventilatory drive increased significantly ( p less than 0 . 05 ) in six subjects ( Type 1 response ) and decreased substantially in the others ( Type 2 response ) ; with hypercapnia , the changes in drive were attenuated in both groups .", + "entities": [] + }, + { + "id": "4998", + "type": "gene", + "text": "Two scintigraphic methods , resting dipyridamole and exercise thallium - 201 myocardial perfusion imaging , to detect and localize coronary artery stenosis were compared in 32 patients suffering from coronary artery disease .", + "entities": [] + }, + { + "id": "4999", + "type": "gene", + "text": "The uteroglobin promoter contains a noncanonical estrogen responsive element .", + "entities": [ + "uteroglobin promoter" + ] + }, + { + "id": "5000", + "type": "gene", + "text": "The examinations were performed on two groups of 20 ( using AmF / SnF2 ) - , resp .", + "entities": [] + }, + { + "id": "5001", + "type": "gene", + "text": "Wild - type and mutant MyoD were introduced into cells using an E1 , E3 - deleted adenoviral vector .", + "entities": [ + "MyoD", + "E1", + "E3" + ] + }, + { + "id": "5002", + "type": "gene", + "text": "Consistent with its role in p53 ubiquitination , mE6 - AP was found both in the nucleus and cytosol , while Nedd - 4 was found only in the cytosol .", + "entities": [ + "p53", + "mE6 - AP", + "Nedd - 4" + ] + }, + { + "id": "5003", + "type": "gene", + "text": "However , one 3 ' splice site , located at nucleotide ( nt ) 3225 , is used for the processing of most BPV - 1 pre - mRNAs in BPV - 1 - transformed C127 cells and at early to intermediate times in productively infected warts .", + "entities": [] + }, + { + "id": "5004", + "type": "gene", + "text": "It was proposed that the synthetase - related sequences of GCN2 stimulate the activity of the kinase by interacting directly with uncharged tRNA that accumulates during amino acid limitation .", + "entities": [ + "GCN2" + ] + }, + { + "id": "5005", + "type": "gene", + "text": "The NF - kappaB responsive reporter construct , ( PRDII ) ( 4 ) - CAT , was used to explore transcription resulting from NF - kappaB activated by Tat .", + "entities": [ + "NF - kappaB", + "( PRDII ) ( 4 )", + "CAT", + "NF - kappaB", + "Tat" + ] + }, + { + "id": "5006", + "type": "gene", + "text": "MAIN OUTCOME MEASURES : Systemic and pulmonary hemodynamics , arterial blood gas determination , bronchoalveolar lavage protein and neutrophil content , neutrophil oxidant burst , lung myeloperoxidase content , and scanning electron micrographic studies .", + "entities": [ + "lung myeloperoxidase" + ] + }, + { + "id": "5007", + "type": "gene", + "text": "We find that beta II PKC phosphorylates nuclear envelope lamin B at 10 - 20 times the rate of alpha PKC , whereas both kinases phosphorylate soluble lamin B at similar rates .", + "entities": [ + "beta II PKC", + "nuclear envelope lamin B", + "alpha PKC", + "soluble lamin B" + ] + }, + { + "id": "5008", + "type": "gene", + "text": "The mechanism by which E2 - C represses E2 - dependent enhancer activity most likely involves competition with E2 for binding to a common transcriptional regulatory site . ( ABSTRACT TRUNCATED AT 400 WORDS )", + "entities": [ + "E2 - C", + "E2 - dependent enhancer", + "E2" + ] + }, + { + "id": "5009", + "type": "gene", + "text": "We have recently detected high levels of CKB mRNA in HeLa cells and , in this study , have tested whether this may be due to the extremely low amounts of p53 protein present in HeLa cells .", + "entities": [ + "CKB mRNA", + "p53 protein" + ] + }, + { + "id": "5010", + "type": "gene", + "text": "These and other data presented suggest that TAg ' re - models ' host cell transcription factors that are used early in viral infection , and thereby mimics an event that naturally occurs during transformation .", + "entities": [ + "TAg" + ] + }, + { + "id": "5011", + "type": "gene", + "text": "The expression of the pilin gene , tcpA , is dependent upon ToxR and upon ToxT .", + "entities": [ + "pilin gene", + "tcpA", + "ToxR", + "ToxT" + ] + }, + { + "id": "5012", + "type": "gene", + "text": "The sequencing of Stellate copies located along the discontinuous cluster revealed a complex pattern of diversification .", + "entities": [ + "Stellate" + ] + }, + { + "id": "5013", + "type": "gene", + "text": "Little is known about the mechanism , but the availability of rapid facile assays for monitoring immunoglobulin hypermutation would greatly aid the development of culture systems for hypermutating B cells as well as the screening for individuals deficient in the process .", + "entities": [ + "immunoglobulin" + ] + }, + { + "id": "5014", + "type": "gene", + "text": "It has come out that CAEC is between CC and CIEC and that attacks of biliary fever and high levels of alkaline phosphatase and transaminases in the serum are the helpful findings for preoperative diagnosis .", + "entities": [ + "alkaline phosphatase" + ] + }, + { + "id": "5015", + "type": "gene", + "text": "When CSF [ HCO3 - ] is shown as a function of CSF PCO2 the data of K - depleted rats are no longer displaced when compared to controls but still have a significantly greater slope ( 1 . 21 + / - 0 . 23 vs .", + "entities": [] + }, + { + "id": "5016", + "type": "gene", + "text": "Identification and estimation of monosaccharides and disaccharides in urine by gas - liquid chromatography .", + "entities": [] + }, + { + "id": "5017", + "type": "gene", + "text": "There was a positive correlation between pyridinium cross - link excretion and thyroid hormone concentrations .", + "entities": [] + }, + { + "id": "5018", + "type": "gene", + "text": "A combination of cisplatin and 5 - fluorouracil , both administered 4 days continuously as infusion , was assessed in advanced head and neck cancer .", + "entities": [] + }, + { + "id": "5019", + "type": "gene", + "text": "Furthermore , phosphatidylinositol ( 3 , 4 , 5 ) trisphosphate specifically stimulates the activity of ILK in vitro , and in addition , membrane targetted constitutively active Pi ( 3 ) K activates ILK in vivo .", + "entities": [ + "ILK", + "Pi ( 3 ) K", + "ILK" + ] + }, + { + "id": "5020", + "type": "gene", + "text": "The predicted amino acid sequence of the SAP - 1 cDNA showed that mature SAP - 1 consisted of 1093 amino acids and a transmembrane - type PTP , which possessed a single PTP - conserved domain in the cytoplasmic region .", + "entities": [ + "SAP - 1 cDNA", + "mature SAP - 1", + "transmembrane - type PTP", + "PTP - conserved domain" + ] + }, + { + "id": "5021", + "type": "gene", + "text": "Incidence correlated with the grade of oral hygiene und periodontal disease .", + "entities": [] + }, + { + "id": "5022", + "type": "gene", + "text": "Endonuclease III ( Nth ) of Escherichia coli is a DNA glycosylase essential for the removal of oxidised pyrimidine base residues from DNA .", + "entities": [ + "Endonuclease III", + "Nth", + "DNA glycosylase" + ] + }, + { + "id": "5023", + "type": "gene", + "text": "Mammalian sperm motility is regulated by a cascade of cAMP - dependent protein phosphorylation events mediated by protein kinase A .", + "entities": [ + "protein kinase A" + ] + }, + { + "id": "5024", + "type": "gene", + "text": "This approach was examined utilizing the fetal protein , HGB F .", + "entities": [ + "HGB F" + ] + }, + { + "id": "5025", + "type": "gene", + "text": "An undilated type of APBD is frequently associated with AMT and we believe , therefore , that clinicians should be aware of a possible coexistence of APBD and AMT .", + "entities": [] + }, + { + "id": "5026", + "type": "gene", + "text": "Nevertheless , we demonstrate that the entire three - component yeast capping apparatus , consisting of RNA 5 ' - triphosphatase ( Cet1p ) , RNA guanylyltransferase ( Ceg1p ) , and Abd1p could be replaced in vivo by the two - component mammalian apparatus consisting of a bifunctional triphosphatase - guanylyltransferase Mce1p and the methyltransferase Hcm1 ( 121 - 476 ) p .", + "entities": [ + "RNA 5 ' - triphosphatase", + "Cet1p", + "RNA guanylyltransferase", + "Ceg1p", + "Abd1p", + "triphosphatase - guanylyltransferase Mce1p", + "methyltransferase Hcm1 ( 121 - 476 ) p" + ] + }, + { + "id": "5027", + "type": "gene", + "text": "Evaluation of myocardial perfusion by 99mTc - tetrofosmin SPECT before and after emergent percutaneous transluminal coronary angioplasty for acute myocardial infarction", + "entities": [] + }, + { + "id": "5028", + "type": "gene", + "text": "With steady illumination , outer retinal ( photoreceptor ) QO2 decreased to 1 . 4 + / - 0 . 9 ml O2 / ( 100 g . min ) , but inner retinal QO2 remained unchanged at 3 . 7 + / - 1 . 5 ml O2 / ( 100 g . min ) ( 5 cats ) .", + "entities": [] + }, + { + "id": "5029", + "type": "gene", + "text": "The lowest culture failure rate of 0 . 2 per cent was found after EAF compared with 0 . 9 per cent among CVS .", + "entities": [] + }, + { + "id": "5030", + "type": "gene", + "text": "We conclude that class I cytologic smears with moderate to severe inflammation may be associated with findings of condylomata and cervical dysplasia .", + "entities": [] + }, + { + "id": "5031", + "type": "gene", + "text": "Physical analysis maps SAL6 to chromosome XVI between TPK2 and spt14 .", + "entities": [ + "SAL6", + "TPK2", + "spt14" + ] + }, + { + "id": "5032", + "type": "gene", + "text": "Results obtained for chloramphenicol - containing preparations are presented , and both dissolution curves and cup - plate assays demonstrate that chloramphenicol has far superior release ( and hence activity ) from creams than from ophthalmic ointments .", + "entities": [] + }, + { + "id": "5033", + "type": "gene", + "text": "However , when combined with mitomycin C given with 1 to 5 - days interval , the concurrent administration of SPG prolonged significantly the life - span of the tumor - bearing mice .", + "entities": [] + }, + { + "id": "5034", + "type": "gene", + "text": "Nipponbare as well as O . australiensis .", + "entities": [] + }, + { + "id": "5035", + "type": "gene", + "text": "Its transcription in vitro by pol III requires the same factors as the U6 gene with the major exception that the modified TATA - box of this construct only interacts with a TATA - binding protein ( TBP ) mutant ( TBP - DR2 ) but not with TBP wild - type ( TBPwt ) .", + "entities": [ + "pol III", + "U6 gene", + "TATA - binding protein", + "TBP", + "TBP - DR2", + "TBP wild - type", + "TBPwt" + ] + }, + { + "id": "5036", + "type": "gene", + "text": "Mining the diagnostic iron ore .", + "entities": [] + }, + { + "id": "5037", + "type": "gene", + "text": "OBJECTIVE : To determine the association of depressive symptoms with HIV - related mortality and decline in CD4 lymphocyte counts among women with HIV .", + "entities": [ + "CD4" + ] + }, + { + "id": "5038", + "type": "gene", + "text": "The p55 mRNA is undetectable in non - EBV - infected B - and T - cell lines or in a myelomonocytic cell line ( U937 ) .", + "entities": [ + "p55 mRNA" + ] + }, + { + "id": "5039", + "type": "gene", + "text": "GCD10 was first identified genetically as a translational repressor of GCN4 .", + "entities": [ + "GCD10", + "GCN4" + ] + }, + { + "id": "5040", + "type": "gene", + "text": "The UV absorption spectrum revealed a shoulder at 250 nm , characteristic of CysS - Cd ( II ) ligand - to - metal charge - transfer transitions , and the difference absorption coefficient after acidification ( delta epsilon 248 , 24 mM - 1 cm - 1 ) indicated the presence of a Cd ( Cys - S ) 4 center .", + "entities": [] + }, + { + "id": "5041", + "type": "gene", + "text": "It was also suggested that the biological activities of 5 - FU , ADM and MMC in FAMLIP were stable in FULIP , ADRLIP and MMCLIP .", + "entities": [] + }, + { + "id": "5042", + "type": "gene", + "text": "DNA binding assays confirmed the interference of p30 ( II ) with the assembly of CREB - Tax - p300 / CBP multiprotein complexes on 21 - bp repeat oligonucleotides in vitro .", + "entities": [ + "p30 ( II )", + "CREB", + "Tax", + "p300", + "CBP" + ] + }, + { + "id": "5043", + "type": "gene", + "text": "This stimulatory effect could also be elicited by c - Jun , which interacts with topo II , but not by c - Fos , which does not bind topo II in our in vitro assay .", + "entities": [ + "c - Jun", + "topo II", + "c - Fos", + "topo II" + ] + }, + { + "id": "5044", + "type": "gene", + "text": "Thus , MKK7 is an essential and specific regulator of stress - induced SAPK / JNK activation in mast cells and MKK7 negatively regulates growth factor and antigen receptor - driven proliferation in hematopoietic cells .", + "entities": [ + "MKK7", + "SAPK", + "JNK", + "MKK7" + ] + }, + { + "id": "5045", + "type": "gene", + "text": "These data suggest that AP - A may be potentially useful in the management of heart failure .", + "entities": [ + "AP - A" + ] + }, + { + "id": "5046", + "type": "gene", + "text": "The first hypothesis was supported in the sense that stimulus differences might affect behaviour even without their successful attentive processing in normal participants .", + "entities": [] + }, + { + "id": "5047", + "type": "gene", + "text": "Family planning continues to play a minor role , and only 25 . 3 per cent of all patients reviewed took to oral contraceptives for shorter or longer periods of time .", + "entities": [] + }, + { + "id": "5048", + "type": "gene", + "text": "- The percentages of primiparae and secundiparae in all births as well as the high percentage of multigravidity are parameters by which the approach to reproduction differs substantively from behaviour patterns in Europe .", + "entities": [] + }, + { + "id": "5049", + "type": "gene", + "text": "Element B ( - 249 / - 229 ) shows more than 80 % homology to a consensus c - myb element , but formed two specific complexes that differed from that of c - myb in the electrophoretic mobility shift assay .", + "entities": [ + "consensus c - myb element", + "c - myb" + ] + }, + { + "id": "5050", + "type": "gene", + "text": "Current clinical trials should answer the question of which of the therapeutic options impairs quality of life less .", + "entities": [] + }, + { + "id": "5051", + "type": "gene", + "text": "In the TVD - patients decreases in skin blood flow were similar compared with the healthy controls .", + "entities": [] + }, + { + "id": "5052", + "type": "gene", + "text": "The serine - threonine kinase gene is likely functional , whereas the zinc finger motif is likely nonfunctional .", + "entities": [ + "serine - threonine kinase gene" + ] + }, + { + "id": "5053", + "type": "gene", + "text": "Two putative 12 - O - tetradecanoyl - phorbol - 13 - acetate ( TPA ) response elements , that might serve as binding sites for the transcription factor AP - 1 and a consensus sequence of a transforming growth factor beta 1 ( TGF - beta 1 ) inhibitory element were found in the promoter region .", + "entities": [ + "transcription factor AP - 1", + "transforming growth factor beta 1", + "TGF - beta 1" + ] + }, + { + "id": "5054", + "type": "gene", + "text": "Fregnac , M .", + "entities": [] + }, + { + "id": "5055", + "type": "gene", + "text": "APETALA3 transcripts are first detected in a meristematic region that will give rise to the petal and stamen primordia , and expression is maintained in this region during subsequent development of these organs .", + "entities": [ + "APETALA3 transcripts" + ] + }, + { + "id": "5056", + "type": "gene", + "text": "Further support for a direct interaction of Tub4p , Spc98p and Spc97p comes from the toxicity of strong SPC97 overexpression which is suppressed by co - overexpression of TUB4 or SPC98 .", + "entities": [ + "Tub4p", + "Spc98p", + "Spc97p", + "SPC97", + "TUB4", + "SPC98" + ] + }, + { + "id": "5057", + "type": "gene", + "text": "Time - activity curves from the gastric region of interest were used , after subjection to appropriate corrective procedures , to calculate the mean gastric transit time ( MTT 90 ) and the fraction of the test meal retained in the stomach after 90 min ( F90 ) .", + "entities": [] + }, + { + "id": "5058", + "type": "gene", + "text": "Phenotypic changes induced by wild type and variant c - src genes carrying C - terminal sequence alterations .", + "entities": [ + "wild type and variant c - src genes" + ] + }, + { + "id": "5059", + "type": "gene", + "text": "Significant correlations between mental status as measured by the Mini - Mental State Examination and NA / mI , mI / Cr and NA were found .", + "entities": [] + }, + { + "id": "5060", + "type": "gene", + "text": "By site - specific mutagenesis , we also show that individual ICP27 C - terminal amino acid residues that are positionally conserved in ICP27 homologs in other herpesviruses ( D - 357 , E - 358 , H - 479 , C - 400 , C - 483 , and C - 488 ) are critical for trans - regulatory activity .", + "entities": [ + "ICP27 C - terminal amino acid residues", + "ICP27 homologs" + ] + }, + { + "id": "5061", + "type": "gene", + "text": "The role of transport by sea ice from the Kara Sea into the Arctic Ocean was assessed by a small subgroup at GEOMAR .", + "entities": [] + }, + { + "id": "5062", + "type": "gene", + "text": "Cotransfection of the coactivator CREB - binding protein relieved the transcriptional repression of PPARalphawt by PPARalphatr , suggesting that the dominant negative effect of PPARalphatr might occur through competition for essential coactivators .", + "entities": [ + "CREB - binding protein", + "PPARalphawt", + "PPARalphatr", + "PPARalphatr" + ] + }, + { + "id": "5063", + "type": "gene", + "text": "Blood serum erythropoietin level and basic hematological indices during the adaptation of healthy newborn infants", + "entities": [ + "Blood serum erythropoietin" + ] + }, + { + "id": "5064", + "type": "gene", + "text": "Objective : To evaluate endometrial thickness and the incidence of uterine bleeding in postmenopausal women using either tibolone 2 . 5 mg or continuous combined 2 mg estradiol and 1 mg norethisterone acetate ( E + NETA ) daily as hormone replacement therapy .", + "entities": [] + }, + { + "id": "5065", + "type": "gene", + "text": "Ovulation was induced in 8 ( 56 . 7 % ) patients who conceived .", + "entities": [] + }, + { + "id": "5066", + "type": "gene", + "text": "Thomas ' Hospital solution ( with 95 % O2 : 5 % CO2 ) can meet the metabolic demand of the ischaemic myocardium and thus increase the safe duration of cardiac arrest .", + "entities": [] + }, + { + "id": "5067", + "type": "gene", + "text": "Myocardial antioxidant enzymes , catalase , glutathione peroxidase and superoxide dismutase , in the MCT - treated rats were not different compared to control rats .", + "entities": [ + "catalase", + "glutathione peroxidase", + "superoxide dismutase" + ] + }, + { + "id": "5068", + "type": "gene", + "text": "New and successful steps have been made in immunodiagnostics , immunotherapy , and immunoprophylaxis of immunologically conditioned infertility .", + "entities": [] + }, + { + "id": "5069", + "type": "gene", + "text": "In 17 patients with deletions , the parental origin of deletion was determined .", + "entities": [] + }, + { + "id": "5070", + "type": "gene", + "text": "Within Stage IA , 141 patients had well differentiated tumor ( G1 ) , 20 had moderately well differentiated tumor ( G2 ) , and 12 patients had poorly differentiated ( G3 ) .", + "entities": [] + }, + { + "id": "5071", + "type": "gene", + "text": "A strong correlation exists between the numbers of CFU - GM transfused and the rate of granulocytes and platelets recovery .", + "entities": [] + }, + { + "id": "5072", + "type": "gene", + "text": "To determine the genetic basis for the differences between the cardiac and brain AE3 variants , we isolated and characterized the rat gene .", + "entities": [ + "brain AE3 variants" + ] + }, + { + "id": "5073", + "type": "gene", + "text": "High ATP / GTP ratios promoted initiation of RNA primer synthesis at 3 ' - dCTTT sites , whereas low ATP / GTP ratios promoted initiation at 3 ' - dCCC sites .", + "entities": [] + }, + { + "id": "5074", + "type": "gene", + "text": "To explore the functional relationship between c - fos and Rb , a eukaryotic expression plasmid was constructed containing the c - fos gene under control of the SV40 promoter complex .", + "entities": [ + "c - fos", + "Rb", + "c - fos gene", + "SV40 promoter" + ] + }, + { + "id": "5075", + "type": "gene", + "text": "The pexB upstream region contained 245 nucleotides within which sequences approximating the consensus for cyclic AMP receptor protein and integration host factor binding sites were discernible .", + "entities": [ + "pexB upstream region", + "cyclic AMP receptor protein", + "integration host factor" + ] + }, + { + "id": "5076", + "type": "gene", + "text": "Substitution of serine residues at the C - terminus indicated that loss of phosphorylation sites did not appear to have any effect on transcription and replication .", + "entities": [] + }, + { + "id": "5077", + "type": "gene", + "text": "The protein is composed of a central alpha - helical portion with globular domains at both NH2 and COOH termini , and the epitope to the monoclonal antibody resides in the central alpha - helical stalk .", + "entities": [] + }, + { + "id": "5078", + "type": "gene", + "text": "RBP56 protein turned out to be hTAFII68 which was isolated as a TATA - binding protein associated factor ( TAF ) from a sub - population of TFIID complexes ( Bertolotti A . , Lutz , Y . , Heard , D . J . , Chambon , P . , Tora , L . , 1996 .", + "entities": [ + "RBP56 protein", + "hTAFII68", + "TATA - binding protein associated factor", + "TAF", + "TFIID complexes" + ] + }, + { + "id": "5079", + "type": "gene", + "text": "hTAFII68 , a novel RNA / ssDNA - binding protein with homology to the proto - oncoproteins TLS / FUS and EWS is associated with both TFIID and RNA polymerase II .", + "entities": [ + "hTAFII68", + "TLS", + "FUS", + "EWS", + "TFIID", + "RNA polymerase II" + ] + }, + { + "id": "5080", + "type": "gene", + "text": "Interestingly , this activation occurred only when the regions were cloned in the same relative orientation in which they exist on wild - type pCF10 .", + "entities": [] + }, + { + "id": "5081", + "type": "gene", + "text": "Their hydropathic plots are very similar and both possess three hydrophobic segments that are likely alpha - helical transmembrane segments .", + "entities": [] + }, + { + "id": "5082", + "type": "gene", + "text": "These results illuminate a hitherto unanticipated function of U6 RNA : the modulation of a phosphorylation - dephosphorylation cycle of C1 hnRNP protein that influences the binding affinity of this protein for pre - mRNA .", + "entities": [ + "U6 RNA", + "C1 hnRNP protein" + ] + }, + { + "id": "5083", + "type": "gene", + "text": "Binding to sulphatides and the alpha - dystroglycan receptor was much stronger and required at least two LG modules .", + "entities": [ + "alpha - dystroglycan receptor", + "LG modules" + ] + }, + { + "id": "5084", + "type": "gene", + "text": "Particles resembling microbodies in normal and neoplastic perianal glands of dogs .", + "entities": [] + }, + { + "id": "5085", + "type": "gene", + "text": "The influence of a mobile pupil on the response in the DC - ERG is demonstrated .", + "entities": [] + }, + { + "id": "5086", + "type": "gene", + "text": "Interdigitated residues within a small region of VP16 interact with Oct - 1 , HCF , and DNA .", + "entities": [ + "VP16", + "Oct - 1", + "HCF" + ] + }, + { + "id": "5087", + "type": "gene", + "text": "The C - terminal end of this polypeptide harbors three types of repeated sequences .", + "entities": [] + }, + { + "id": "5088", + "type": "gene", + "text": "Study groups were control , and those treated with the alpha1 - adrenoceptor - subtype blockers WB4101 ( 0 . 5 mg / kg i . v . ) or chloroethylclonidine ( 1 . 9 mg / kg i . v . ) .", + "entities": [ + "alpha1 - adrenoceptor - subtype" + ] + }, + { + "id": "5089", + "type": "gene", + "text": "This study provides direct evidence that USF , a member of the basic helix - loop - helix leucine zipper family , binds to MLE1 , HF - 1a , and PRE B sites and suggests that it is a component of protein complexes that may coordinately control the expression of MLC - 2v and alpha - myosin heavy - chain genes .", + "entities": [ + "USF", + "basic helix - loop - helix leucine zipper family", + "MLE1", + "HF - 1a", + "PRE B sites", + "MLC - 2v", + "alpha - myosin heavy - chain genes" + ] + }, + { + "id": "5090", + "type": "gene", + "text": "Surprisingly , double mutants of the shy2 - 1D mutant with the phytochrome - deficient mutants hy2 , hy3 ( phyB - 1 ) and fre1 - 1 ( phyA - 201 ) showed reduced photomorphogenic response in darkness with a longer hypocotyl , a longer inflorescence stem , and a lower level expression of the CAB gene than the shy2 - 1D single mutant .", + "entities": [ + "shy2 - 1D mutant", + "phytochrome", + "hy2", + "hy3", + "phyB - 1", + "fre1 - 1", + "phyA - 201", + "CAB gene", + "shy2 - 1D single mutant" + ] + }, + { + "id": "5091", + "type": "gene", + "text": "The gcd2 - 503 mutation also results in polysome runoff , accumulation of inactive 80S ribosomal couples , and accumulation of at least one of the subunits of the general translation initiation factor 2 ( eIF - 2 alpha ) in 43S - 48S particles following a shift to the restrictive temperature .", + "entities": [ + "gcd2 - 503", + "80S ribosomal couples", + "general translation initiation factor 2", + "eIF - 2 alpha", + "43S", + "48S" + ] + }, + { + "id": "5092", + "type": "gene", + "text": "Auditory clicks were given at a rate of 20 s ( - 1 ) .", + "entities": [] + }, + { + "id": "5093", + "type": "gene", + "text": "Removal of beta 2 - microglobulin by hemodialysis and hemofiltration : a four year follow up .", + "entities": [ + "beta 2 - microglobulin" + ] + }, + { + "id": "5094", + "type": "gene", + "text": "However , excretion of 6 - keto - prostaglandin F1 alpha was further reduced in the smokers who used oral contraceptives ( 133 + / - 20 to 86 + / - 9 ng / gm of creatinine , p less than 0 . 05 ) .", + "entities": [] + }, + { + "id": "5095", + "type": "gene", + "text": "Disturbances of placental maturation , 2 .", + "entities": [] + }, + { + "id": "5096", + "type": "gene", + "text": "Removal of beta 2 - microglobulin by hemodialysis and hemofiltration : a four year follow up .", + "entities": [ + "beta 2 - microglobulin" + ] + }, + { + "id": "5097", + "type": "gene", + "text": "The effect of sodium saccharin in the diet on caecal microflora .", + "entities": [] + }, + { + "id": "5098", + "type": "gene", + "text": "Indium - 111 OncoScint CR / OV and F - 18 FDG in colorectal and ovarian carcinoma recurrences .", + "entities": [] + }, + { + "id": "5099", + "type": "gene", + "text": "All anti - I and anti - i CA were shown to express VH4 heavy chains , and 14 of 17 CA expressed a previously described VH4 second hypervariable region determinant , termed VH4 - HV2a .", + "entities": [ + "anti - I", + "anti - i CA", + "VH4 heavy chains", + "CA", + "VH4", + "VH4 - HV2a" + ] + }, + { + "id": "5100", + "type": "gene", + "text": "Continued absorption of amino acids by the NBB carrier ( for neutral amino acids ) , the Y + system ( for dibasic amino acids ) , and the PHE carrier were operative even during the actively purging stage of watery diarrhoea due to cholera .", + "entities": [] + }, + { + "id": "5101", + "type": "gene", + "text": "Is criticism of patient care justified and does it have educational value ?", + "entities": [] + }, + { + "id": "5102", + "type": "gene", + "text": "Patients ' criticism contributes to improved patient care", + "entities": [] + }, + { + "id": "5103", + "type": "gene", + "text": "CD7 + / CD3 - T - cell precursors exhibit V delta 2D delta 3 rearrangements .", + "entities": [ + "CD7", + "CD3", + "V delta 2D delta 3 rearrangements" + ] + }, + { + "id": "5104", + "type": "gene", + "text": "METHODS : Four hundred fifty patients with the diagnosis of squamous cell carcinoma of the oral cavity received their primary treatment at Roswell Park Cancer Center ( RPCI ) from 1971 to 1991 .", + "entities": [] + }, + { + "id": "5105", + "type": "gene", + "text": "In reperfusion B , only the diabetic group demonstrated a significant increase in IL - 8 concentrations at 1 and 15 min compared to nondiabetics .", + "entities": [ + "IL - 8" + ] + }, + { + "id": "5106", + "type": "gene", + "text": "When Hy - Vac SPF type V embryos were exposed to either 0 . 20 ml 50 % ethanol in CRS or to 0 . 20 ml CRS ( controls ) , ethanol - treated embryos showed a VSD incidence of 34 . 1 % compared with a 3 . 6 % incidence in the controls ( P = 0 . 0017 ) .", + "entities": [] + }, + { + "id": "5107", + "type": "gene", + "text": "The injection of XDRP1 protein into fertilized Xenopus eggs blocked embryonic cell division .", + "entities": [ + "XDRP1 protein" + ] + }, + { + "id": "5108", + "type": "gene", + "text": "( 1986 ) method of separation of Cryptosporidium spp . oocysts from feces by using a percoll discontinuous density gradient appeared a method of choice for obtaining large numbers of oocysts of C . parvum free of fecal contamination .", + "entities": [] + }, + { + "id": "5109", + "type": "gene", + "text": "The ARG SH2 domain exhibited relatively weak affinity for BCR and was determined to bind about 10 - fold less strongly than the ABL SH2 domain .", + "entities": [ + "SH2 domain", + "BCR", + "SH2 domain" + ] + }, + { + "id": "5110", + "type": "gene", + "text": "The pulmonary toxic events induced by acute nitrogen dioxide ( NO ) 2 exposure were studied in the rat to develop an inhalation model to investigate therapeutic measures .", + "entities": [] + }, + { + "id": "5111", + "type": "gene", + "text": "The adenovirus E1A gene encodes a protein that transcriptionally activates viral early genes .", + "entities": [ + "adenovirus E1A gene", + "viral early genes" + ] + }, + { + "id": "5112", + "type": "gene", + "text": "These results suggest that XAB1 is a novel cytoplasmic GTPase involved in nuclear localization of XPA .", + "entities": [ + "XAB1", + "cytoplasmic GTPase", + "XPA" + ] + }, + { + "id": "5113", + "type": "gene", + "text": "Using a degenerate oligodeoxyribonucleotide ( oligo ) based on the N - terminal aa sequence , plus an internal oligo homologous to a conserved region within the portion of CYP1 and CYP2 that had been deleted in the genome , a CYP3 - specific DNA fragment was generated by the polymerase chain reaction ( PCR ) using GL81 genomic DNA as a substrate .", + "entities": [ + "CYP1", + "CYP2", + "CYP3 - specific DNA fragment" + ] + }, + { + "id": "5114", + "type": "gene", + "text": "The multiple factors affecting plasma renin activity in essential hypertension .", + "entities": [ + "renin" + ] + }, + { + "id": "5115", + "type": "gene", + "text": "The smallest active FecR derivative contained 59 amino acid residues as compared to the 317 residues of wild - type FecR .", + "entities": [ + "active FecR derivative", + "wild - type FecR" + ] + }, + { + "id": "5116", + "type": "gene", + "text": "Ti exhibited a feather - like morphology .", + "entities": [] + }, + { + "id": "5117", + "type": "gene", + "text": "Utilization of alternative polyadenylation signals was previously shown to generate two sialophorin mRNAs of 1 . 9 and 4 . 3 kb , which differ in the length of their 3 ' untranslated regions .", + "entities": [ + "sialophorin mRNAs of 1 . 9 and 4 . 3 kb" + ] + }, + { + "id": "5118", + "type": "gene", + "text": "Is nisoldipine capable of reducing left ventricular preload ?", + "entities": [] + }, + { + "id": "5119", + "type": "gene", + "text": "In ten anesthetized pigs , nisoldipine ( 2 - 4 micrograms X kg - 1 X min - 1 ) , a calcium channel blocker structurally related to nifedipine , reduced left ventricular systolic pressure ( 40 % ) and systemic vascular resistance ( 35 % ) , whereas maxLVdP / dt decreased by 20 % and cardiac output was unchanged .", + "entities": [] + }, + { + "id": "5120", + "type": "gene", + "text": "With the modified fingertip - to - floor ( MFTF ) method , patients stand on a stool and forward bend so that measurements can be taken on patients who are able to touch the floor or reach beyond the level of the floor .", + "entities": [] + }, + { + "id": "5121", + "type": "gene", + "text": "An explanation explored for this lack of gene expression was that increased levels of RAR alpha or PML might suppress APL cell growth .", + "entities": [ + "RAR alpha", + "PML" + ] + }, + { + "id": "5122", + "type": "gene", + "text": "Spliced exons of adenovirus late RNAs colocalize with snRNP in a specific nuclear domain .", + "entities": [] + }, + { + "id": "5123", + "type": "gene", + "text": "Despite the existence of 30 cysteine residues , carboxymethylation prevented the formation of most if not all disulfide bonds that otherwise occurred when the cells were sonicated .", + "entities": [] + }, + { + "id": "5124", + "type": "gene", + "text": "To determine the true molecular identity of SFD , both the 50 - and 57 - kDa polypeptides were directly sequenced .", + "entities": [ + "SFD" + ] + }, + { + "id": "5125", + "type": "gene", + "text": "The lines also differed in postsynaptic , but not presynaptic , 5 - HT1A receptors .", + "entities": [ + "5 - HT1A receptors" + ] + }, + { + "id": "5126", + "type": "gene", + "text": "The C - terminal domains ( CTDs ) of the RPase beta subunit and DNA primase ( dnaG protein ) were not only strongly homologous to each other but also considerably homologous to the RPase alpha , suggesting that an alpha subunit - like enzyme must have been commonly ancestral to core enzyme subunits and primase .", + "entities": [ + "RPase beta subunit", + "DNA primase", + "dnaG protein", + "RPase alpha", + "core enzyme subunits", + "primase" + ] + }, + { + "id": "5127", + "type": "gene", + "text": "Thus , the L45 sequence between kinase subdomains IV and V specifies TGF - beta responsiveness of the type I receptor .", + "entities": [ + "TGF - beta", + "type I receptor" + ] + }, + { + "id": "5128", + "type": "gene", + "text": "Moreover , xTAK1KN could block the expression of ventral mesoderm marker genes induced by Smad1 or 5 .", + "entities": [ + "xTAK1KN", + "Smad1 or 5" + ] + }, + { + "id": "5129", + "type": "gene", + "text": "On Days 1 and 14 , most young and elderly subjects exhibited monoexponential decline in bevantolol plasma concentrations after absorption phase .", + "entities": [] + }, + { + "id": "5130", + "type": "gene", + "text": "The pp90rsk - protein kinase activity ( referred to as rsk - kinase ) is also not related to cofactor - dependent signal transducing protein kinases such as the cyclic AMP - dependent protein kinases , members of the protein kinase C family , or other Ca2 ( + ) - dependent protein kinases .", + "entities": [ + "pp90rsk - protein kinase", + "rsk - kinase", + "cyclic AMP - dependent protein kinases", + "protein kinase C family", + "Ca2 ( + ) - dependent protein kinases" + ] + }, + { + "id": "5131", + "type": "gene", + "text": "Improvement of nursing instruction to be given at the time of discharge from the ward for premature infants", + "entities": [] + }, + { + "id": "5132", + "type": "gene", + "text": "The primary structure of a 2671 bp DNA fragment between the pla gene ( encoding plasminogen activator ) and the origin of replication of the wild - type Yersinia pestis plasmid pYP358 was determined .", + "entities": [ + "pla gene", + "plasminogen activator" + ] + }, + { + "id": "5133", + "type": "gene", + "text": "Group psychometric functions for listeners with hearing loss do not show a decrease in performance at the largest values of delta f included in this study .", + "entities": [] + }, + { + "id": "5134", + "type": "gene", + "text": "To date , two such proteins , PLZF and LAZ - 3 / BCL - 6 , have been implicated in oncogenesis .", + "entities": [ + "PLZF", + "LAZ - 3", + "BCL - 6" + ] + }, + { + "id": "5135", + "type": "gene", + "text": "There is general agreement that the hepatitis C virus is efficiently transmitted parenterally , while data on viral transmission from mothers to babies or by sexual or non - sexual household contact are conflicting .", + "entities": [] + }, + { + "id": "5136", + "type": "gene", + "text": "1993 .", + "entities": [] + }, + { + "id": "5137", + "type": "gene", + "text": "APC - resistance was determined with a functional method with high sensitivity and specificity for the factor V Leiden mutation .", + "entities": [ + "APC", + "factor V Leiden mutation" + ] + }, + { + "id": "5138", + "type": "gene", + "text": "The Drosophila melanogaster Gart gene encodes three enzymatic activities in the pathway for purine de novo synthesis .", + "entities": [ + "Drosophila melanogaster Gart gene" + ] + }, + { + "id": "5139", + "type": "gene", + "text": "Lacrimal secretion in hyperthyroidism", + "entities": [] + }, + { + "id": "5140", + "type": "gene", + "text": "Conditions influencing inhibitors of the colony - stimulating factor ( CSF ) .", + "entities": [ + "colony - stimulating factor", + "CSF" + ] + }, + { + "id": "5141", + "type": "gene", + "text": "These results suggest that indoramin may have Class III antiarrhythmic activity .", + "entities": [] + }, + { + "id": "5142", + "type": "gene", + "text": "Although Micrococcus luteus UV endonuclease has been reported to be an 18 - kDa enzyme with possible homology to the 16 - kDa endonuclease V from bacteriophage T4 ( Gordon , L .", + "entities": [ + "Micrococcus luteus UV endonuclease", + "16 - kDa endonuclease V from bacteriophage T4" + ] + }, + { + "id": "5143", + "type": "gene", + "text": "Another common mutation involved amino acids that are thought to make specific contacts with DNA .", + "entities": [] + }, + { + "id": "5144", + "type": "gene", + "text": "GTRE , TRE , and CRE oligonucleotides all compete more efficiently for protein binding to their labeled congeners than for protein binding to either of the other labeled oligonucleotides , suggesting that the GTRE , TRE , and CRE oligonucleotides , suggesting that the GTRE , TRE , and CRE oligonucleotides each bind unique as well as common proteins , likely to be members of the Jun / Fos and cAMP - responsive element - binding protein / activating transcription factors ( CREB / ATF ) families of transcription factors , in chromaffin cells .", + "entities": [ + "Jun", + "Fos", + "cAMP - responsive element - binding protein", + "activating transcription factors", + "CREB", + "ATF" + ] + }, + { + "id": "5145", + "type": "gene", + "text": "To explore the functional significance of these subdomains in PRL binding and signal transduction , deletion mutants of S1 or / and S2 subdomains were constructed .", + "entities": [ + "PRL" + ] + }, + { + "id": "5146", + "type": "gene", + "text": "Interference with rheumatoid factor was only observed in the ELISA enzygnost if sera were not pretreated with latex adsorbents .", + "entities": [ + "rheumatoid factor" + ] + }, + { + "id": "5147", + "type": "gene", + "text": "Patients with low probability of having aluminum overload ( serum iron levels < 40 micrograms / L and DAI < 150 micrograms / L ) had significantly higher values of serum iron , iron transferrin saturation , and serum ferritin levels compared with those patients with a high probability of having aluminum overload ( serum aluminum levels > 40 micrograms / L and DAI > 150 micrograms / L ) .", + "entities": [ + "transferrin", + "serum ferritin" + ] + }, + { + "id": "5148", + "type": "gene", + "text": "A variety of receptor - mediated signaling pathways are controlled by both positive and negative extracellular regulators .", + "entities": [] + }, + { + "id": "5149", + "type": "gene", + "text": "The artery cuff was slightly superior to the fat wrap , particularly in having fewer adhesions and a better histological picture .", + "entities": [] + }, + { + "id": "5150", + "type": "gene", + "text": "The position , transcription orientation , and imprinted status of the genes immediately flanking Igf2r have been assessed .", + "entities": [ + "Igf2r" + ] + }, + { + "id": "5151", + "type": "gene", + "text": "Furthermore , the DNA polymerase II complex was difficult to obtain from dpb2 - 1 mutant cells , suggesting that a stable DNA polymerase II complex requires DPB2 and is essential for chromosomal replication .", + "entities": [ + "DNA polymerase II complex", + "dpb2 - 1", + "DNA polymerase II complex", + "DPB2" + ] + }, + { + "id": "5152", + "type": "gene", + "text": "A developmentally regulated 4 . 6 kb mRNA is recognized on Northern blots of oocyte RNA using the X . laevis cDNA .", + "entities": [] + }, + { + "id": "5153", + "type": "gene", + "text": "We show that stimulation of resting splenic B cells with CD40L - expressing Sf9 cells induces germ - line gamma 1 and epsilon transcripts independently of cytokines .", + "entities": [ + "CD40L" + ] + }, + { + "id": "5154", + "type": "gene", + "text": "The positive - acting global sulfur regulatory protein , CYS3 , of Neurospora crassa turns on the expression of a family of unlinked structural genes that encode enzymes of sulfur catabolism .", + "entities": [ + "CYS3" + ] + }, + { + "id": "5155", + "type": "gene", + "text": "Molecular cloning of a cysteine synthase cDNA from Citrullus vulgaris ( watermelon ) by genetic complementation in an Escherichia coli Cys - auxotroph .", + "entities": [ + "cysteine synthase cDNA" + ] + }, + { + "id": "5156", + "type": "gene", + "text": "In a randomized single - blind 3 x 3 Latin - square study with corrections for any carryover effects , 27 males and 30 females consumed supplements containing glucose or resistant starch ( RS ) from raw high - amylose cornstarch ( RS2 ) or from retrograded high - amylose cornstarch ( RS3 ) .", + "entities": [] + }, + { + "id": "5157", + "type": "gene", + "text": "The cytoprotective and antiulcer activities of the antacid magaldrate ( ES Riopan ) as well as its effects on gastric mucosal blood flow and mucus secretions , were determined in the rat .", + "entities": [] + }, + { + "id": "5158", + "type": "gene", + "text": "Antithrombin III prevents 60 min warm intestinal ischemia reperfusion injury in rats .", + "entities": [ + "Antithrombin III" + ] + }, + { + "id": "5159", + "type": "gene", + "text": "Sibling aggregation of low - and high - density lipoprotein cholesterol and apolipoproteins B and A - I levels in black and white children : the Bogalusa Heart Study .", + "entities": [ + "low - and high - density lipoprotein cholesterol", + "apolipoproteins B and A - I" + ] + }, + { + "id": "5160", + "type": "gene", + "text": "The effect of dietary zinc deficiency on the mossy fiber zinc content of the rat hippocampus .", + "entities": [] + }, + { + "id": "5161", + "type": "gene", + "text": "RNase protection and primer extension assays confirmed that the 5 ' non - coding exon is included in the DDT1 aFGF mRNA and that a major transcription start site is approximately 136 bp upstream of the 5 ' non - coding splice junction of this exon .", + "entities": [ + "RNase", + "aFGF mRNA" + ] + }, + { + "id": "5162", + "type": "gene", + "text": "Two other peptides , either partially or totally lacking the basic region , but containing the intact leucine zipper domain , readily form dimers but do not bind to the CRE .", + "entities": [] + }, + { + "id": "5163", + "type": "gene", + "text": "However , we were unable to identify a p4 molecule .", + "entities": [ + "p4" + ] + }, + { + "id": "5164", + "type": "gene", + "text": "There were minimal negative effects on hematological parameters , acid - base status , and blood gases .", + "entities": [] + }, + { + "id": "5165", + "type": "gene", + "text": "ERK MAP kinase links cytokine signals to activation of latent HIV - 1 infection by stimulating a cooperative interaction of AP - 1 and NF - kappaB .", + "entities": [ + "MAP kinase", + "AP - 1", + "NF - kappaB" + ] + }, + { + "id": "5166", + "type": "gene", + "text": "CONCLUSIONS : Two consecutive sets of transrectal ultrasound guided sextant biopsies of the prostate performed in a single office visit represent a cost - effective biopsy strategy for men presenting with an abnormal digital rectal examination and / or elevated serum PSA .", + "entities": [ + "serum PSA" + ] + }, + { + "id": "5167", + "type": "gene", + "text": "At 20 days ( D ) and at 3 months post - TBI , irradiated rats had a significantly lower percentage of avoidance than controls but no statistical difference was found at 5 months post - TBI .", + "entities": [] + }, + { + "id": "5168", + "type": "gene", + "text": "b / Two - way avoidance test : this test was performed only after TBI .", + "entities": [] + }, + { + "id": "5169", + "type": "gene", + "text": "The data normally available are insufficient and take no account of the direction of recirculation , which may be a determining factor .", + "entities": [] + }, + { + "id": "5170", + "type": "gene", + "text": "In addition , two internal promoters , PmiaA and P1hfq were identified and mapped to 201 and 837 nucleotides upstream from the respective translation start sites .", + "entities": [ + "PmiaA", + "P1hfq" + ] + }, + { + "id": "5171", + "type": "gene", + "text": "Internally oriented patients ' scores on Rotter ' s Internal - External Locus of Control Scale remained the same over treatment but those of externally oriented patients shifted toward greater internal control .", + "entities": [] + }, + { + "id": "5172", + "type": "gene", + "text": "Long - latency : locked units responded to shocks with little jitter and long latency ( 4 - 11 ms ) .", + "entities": [] + }, + { + "id": "5173", + "type": "gene", + "text": "Two new temperature - sensitive alleles of SEC3 , 1 of 10 late - acting SEC genes required for targeting or fusion of post - Golgi secretory vesicles to the plasma membrane in Saccharomyces cerevisiae , were isolated in a screen for temperature - sensitive secretory mutants that are synthetically lethal with sec4 - 8 .", + "entities": [ + "SEC3", + "SEC genes", + "sec4 - 8" + ] + }, + { + "id": "5174", + "type": "gene", + "text": "The relative tumor FDG - uptake ( Q - MRGlu ) ( tumor / contralateral cortex ) of all meningiomas was calculated with 0 . 73 + / - 0 . 37 ( 0 . 24 - 1 . 79 ) .", + "entities": [] + }, + { + "id": "5175", + "type": "gene", + "text": "Gab2 , a new pleckstrin homology domain - containing adapter protein , acts to uncouple signaling from ERK kinase to Elk - 1 .", + "entities": [ + "Gab2", + "pleckstrin", + "ERK kinase", + "Elk - 1" + ] + }, + { + "id": "5176", + "type": "gene", + "text": "In earlier studies we identified several regulatory elements that control transcriptional activation and aerobic repression of one of these genes , COX5b .", + "entities": [ + "COX5b" + ] + }, + { + "id": "5177", + "type": "gene", + "text": "Neuro - otological examinations revealed spontaneous downbeat nystagmus , bilateral gaze nystagmus and rebound nystagmus .", + "entities": [] + }, + { + "id": "5178", + "type": "gene", + "text": "Electrophoretic mobility shift assays ( EMSAs ) using purified glucocorticoid receptor DNA binding domain ( DBD ) demonstrated that both GRE - 2 and - 3 motifs interact with DBD and oligonucleotide competition experiments established that these have different affinities for DBD .", + "entities": [ + "glucocorticoid receptor DNA binding domain", + "GRE - 2 and - 3 motifs" + ] + }, + { + "id": "5179", + "type": "gene", + "text": "W .", + "entities": [] + }, + { + "id": "5180", + "type": "gene", + "text": "These modifications may improve the interlaboratory reproducibility of CD34 determinations due to the reduction in sample handling and calculation of results .", + "entities": [ + "CD34" + ] + }, + { + "id": "5181", + "type": "gene", + "text": "In group B 37 MBq in 150 microL of 99mTc - HSA nanocolloid was additionally injected intradermally 18 h before surgery ( 3 - 6 aliquots injected perilesionally ) .", + "entities": [] + }, + { + "id": "5182", + "type": "gene", + "text": "Familial glutathione reductase deficiency and disorder of glutathione synthesis in the erythrocyte", + "entities": [ + "glutathione reductase" + ] + }, + { + "id": "5183", + "type": "gene", + "text": "Homozygous protein C ( PC ) deficiency is reported in two siblings ( girl and boy ) who received their proper diagnoses at the ages of 7 4 / 12 and 1 3 / 12 years respectively .", + "entities": [ + "protein C", + "PC" + ] + }, + { + "id": "5184", + "type": "gene", + "text": "267 , 4870 - 4877 ) ) indicates an overall identity of 58 and 56 % , respectively , with a 91 and 92 % identity in the highly conserved transmembrane and cytoplasmic domains .", + "entities": [] + }, + { + "id": "5185", + "type": "gene", + "text": "Taxonomically significant colour changes in Brevibacterium linens probably associated with a carotenoid - like pigment .", + "entities": [] + }, + { + "id": "5186", + "type": "gene", + "text": "The findings demonstrate that AMPH administration induces a significant increase in the height of a major electroactive peak in the caudate nucleus of pigtail monkeys , and further that such amphetamine - induced increases can be manipulated by altering the affective and / or emotional state of the animal .", + "entities": [] + }, + { + "id": "5187", + "type": "gene", + "text": "Recently , cell - surface TRAIL has been shown to be expressed by activated human and mouse T lymphocytes , raising the possibility that TRAIL might be involved in T cell - mediated cytotoxicity and / or immune regulation .", + "entities": [ + "TRAIL", + "TRAIL" + ] + }, + { + "id": "5188", + "type": "gene", + "text": "UVA - induced melanocytic lesions .", + "entities": [] + }, + { + "id": "5189", + "type": "gene", + "text": "Contingency contracting between clients and their parents / caregivers was used to specify consequences for daily self - monitoring , reduced caloric intake , weight loss , and exercise .", + "entities": [] + }, + { + "id": "5190", + "type": "gene", + "text": "Mutations within human UTR1 modulate NRF - 1 expression by interfering with mRNA translational efficiency in transfected cells and in an in vitro translation system .", + "entities": [ + "NRF - 1" + ] + }, + { + "id": "5191", + "type": "gene", + "text": "The results suggest that the organization of functional units of the 72 - bp repeat required for transcriptional enhancement of the early promoter is different from that required for late promoter function .", + "entities": [] + }, + { + "id": "5192", + "type": "gene", + "text": "If , however , the mean temperature rise was higher ( 0 . 57 degrees C or 0 . 69 degrees C ) , such a selection practically resulted in the disappearance of ' passable ' qualifications in the triplet groups and a great predominance of ' to be rejected ' qualifications in the large groups .", + "entities": [] + }, + { + "id": "5193", + "type": "gene", + "text": "Low affinity binding of Rab6A - GTP was also observed ( K ( d ) = 16 microm ) , whereas Rab1B , - 5 , - 7 , - 8 , or - 11A did not bind .", + "entities": [ + "Rab6A - GTP", + "Rab1B , - 5 , - 7 , - 8 , or - 11A" + ] + }, + { + "id": "5194", + "type": "gene", + "text": "RESULTS : At the beginning of the QA / QI process , monitoring of blood administration practices revealed that a variance from institutional blood administration policy occurred during 50 percent of blood and component transfusions .", + "entities": [] + }, + { + "id": "5195", + "type": "gene", + "text": "The AL - R8 SI : the next generation staging container for plutonium pits at the USDOE Pantex Plant .", + "entities": [] + }, + { + "id": "5196", + "type": "gene", + "text": "Four transcription initiation sites have been identified by full - length RNA ligase - mediated rapid amplification of cDNA ends ( RLM - RACE ) between - 61 and - 32 bp from the translation initiation codon . Reverse transcription - PCR analysis revealed that PFK - A , PFK - B and PFK - C genes were expressed , in all mouse tissues tested , at varying levels .", + "entities": [ + "RNA ligase", + "PFK - A", + "PFK - B", + "PFK - C genes" + ] + }, + { + "id": "5197", + "type": "gene", + "text": "Tissue - specific expression of the diazepam - binding inhibitor in Drosophila melanogaster : cloning , structure , and localization of the gene .", + "entities": [ + "diazepam - binding inhibitor" + ] + }, + { + "id": "5198", + "type": "gene", + "text": "Since MEK acts as a cytoplasmic anchor for the ERKs , the lack of a MEK interaction resulted in the aberrant nuclear localization of ERK2 - Delta19 - 25 mutants in serum - starved cells .", + "entities": [ + "MEK", + "ERKs", + "MEK", + "ERK2", + "Delta19 - 25" + ] + }, + { + "id": "5199", + "type": "gene", + "text": "Differential signaling and immediate - early gene activation by four splice variants of the human pituitary adenylate cyclase - activating polypeptide receptor ( hPACAP - R ) .", + "entities": [ + "immediate - early gene", + "human pituitary adenylate cyclase - activating polypeptide receptor", + "hPACAP - R" + ] + }, + { + "id": "5200", + "type": "gene", + "text": "Selective bronchial intubation in the management of unilateral pulmonary interstitial emphysema .", + "entities": [] + }, + { + "id": "5201", + "type": "gene", + "text": "These results also suggest the involvement of additional elements in the UPR .", + "entities": [] + }, + { + "id": "5202", + "type": "gene", + "text": "Furthermore , unlike the case for HIS3 where only a limited subset of TATA - like sequences can activate transcription in conjunction with GCN4p , many divergent TATA - like sequences allowed GCN4p activation of TRP3 .", + "entities": [ + "HIS3", + "GCN4p", + "GCN4p", + "TRP3" + ] + }, + { + "id": "5203", + "type": "gene", + "text": "With this GH and estrogen treatment regimen , most girls with TS can grow and develop much more in conformity with their healthy peers .", + "entities": [ + "GH" + ] + }, + { + "id": "5204", + "type": "gene", + "text": "After 14 d of overfeeding , hepatic PL profiles were identical in the two breeds and similar to that in control livers ; choline - containing PL accounted for 95 % of total PL .", + "entities": [] + }, + { + "id": "5205", + "type": "gene", + "text": "Modifications of the involuntary postcontraction in diseased people .", + "entities": [] + }, + { + "id": "5206", + "type": "gene", + "text": "The cpc - 1 - encoded transcript contains three open reading frames , two of which are located in the 720 - nucleotide leader segment preceding the cpc - 1 coding region .", + "entities": [ + "cpc - 1 - encoded transcript", + "cpc - 1 coding region" + ] + }, + { + "id": "5207", + "type": "gene", + "text": "Commonly used stressors are mental arithmetics , speech tasks , the Stroop test , videogame playing , films or videotapes and interviews .", + "entities": [] + }, + { + "id": "5208", + "type": "gene", + "text": "Spatial zones for muscle coactivation and the control of postural stability .", + "entities": [] + }, + { + "id": "5209", + "type": "gene", + "text": "In strains lacking tup11 and tup12 , the atf1 - pcr1 transcriptional activator continues to play a central role in fbp1 - lacZ expression ; however , spc1 MAPK phosphorylation of atf1 is no longer essential for its activation .", + "entities": [ + "tup11", + "tup12", + "atf1", + "pcr1", + "fbp1", + "lacZ", + "spc1 MAPK", + "atf1" + ] + }, + { + "id": "5210", + "type": "gene", + "text": "As extensively examined with the myogenin promoter , presence of one or multiple copies of Me in the vectors elevated the expression activity in myotubes by 4 . 5 - to 19 - fold over those without Me , but not significantly in myoblasts .", + "entities": [ + "myogenin promoter", + "Me", + "Me" + ] + }, + { + "id": "5211", + "type": "gene", + "text": "The C - terminal Cdk2 truncations , however , were non - functional in these strains and thus dependent for activity on the pho85 coding region which remained in the mutant pho85 : : HIS3 chromosomal locus .", + "entities": [ + "C - terminal Cdk2", + "pho85 coding region", + "mutant pho85", + "HIS3 chromosomal locus" + ] + }, + { + "id": "5212", + "type": "gene", + "text": "Treatment of N18TG - 2 cells with a demethylating agent , 5 - aza - deoxycytidine , resulted in an expression of mlt 1 , indicating that the repression of mlt 1 is attributable to methylation Thus , mlt 1 is a novel target gene that is silenced by methylation during liver tumorigenesis initiated by SV40 T antigen .", + "entities": [ + "mlt 1", + "mlt 1", + "mlt 1", + "SV40 T antigen" + ] + }, + { + "id": "5213", + "type": "gene", + "text": "SPECT is an important aid in the diagnosis of AIDS dementia complex and contributes to the understanding of the pathophysiological mechanisms of this disorder .", + "entities": [] + }, + { + "id": "5214", + "type": "gene", + "text": "Studies have substantiated the involvement of numerous loci on certain chromosomes ; in excess of 10 chromosomes are thought to be involved .", + "entities": [] + }, + { + "id": "5215", + "type": "gene", + "text": "Eight CAD patients who were matched to the treated patients for age ( + / - 3 years ) , baseline low density lipoprotein ( + / - 5 mg / dL ) , and triglycerides ( + / - 50 mg / dL ) but who had never been treated with lipid - lowering drugs were selected as controls .", + "entities": [ + "low density lipoprotein" + ] + }, + { + "id": "5216", + "type": "gene", + "text": "Review of the literature and report of a case of a dermoid cyst .", + "entities": [] + }, + { + "id": "5217", + "type": "gene", + "text": "An intact 5 . 7 - kb provirus of the avian erythroblastosis virus E26 has been molecularly cloned for comparisons with avian myeloblastosis virus ( AMV ) and other avian tumor viruses .", + "entities": [] + }, + { + "id": "5218", + "type": "gene", + "text": "Thyrotropin - induced expression of a gene for a ribosomal protein related to the trk oncogene .", + "entities": [ + "Thyrotropin", + "ribosomal protein", + "trk oncogene" + ] + }, + { + "id": "5219", + "type": "gene", + "text": "These findings suggest that the F - wave may be elicited in motoneuron of different depolarization threshold but primarily in larger and faster nerve fibers , with a lower threshold of depolarization .", + "entities": [] + }, + { + "id": "5220", + "type": "gene", + "text": "The molecular weight of in vivo - labeled proteins was increased relative to that of in vitro - translated proteins , indicating that a posttranslational modification had occurred .", + "entities": [] + }, + { + "id": "5221", + "type": "gene", + "text": "Change in plasma cystyl aminopeptidase ( oxytocinase ) between 30 - 34 weeks ' gestation as a predictor of pregnancy - induced hypertension .", + "entities": [ + "plasma cystyl aminopeptidase", + "oxytocinase" + ] + }, + { + "id": "5222", + "type": "gene", + "text": "Sterol analysis of the disrupted mutant demonstrated the accumulation of ignosterol , indicating a loss of Erg24p activity .", + "entities": [ + "Erg24p" + ] + }, + { + "id": "5223", + "type": "gene", + "text": "However , ICK1 was induced by ABA , and along with ICK1 induction there was a decrease in Cdc2 - like histone H1 kinase activity .", + "entities": [ + "ICK1", + "ICK1", + "histone H1 kinase" + ] + }, + { + "id": "5224", + "type": "gene", + "text": "Light regulatory unit 1 ( LRU1 ) is necessary for and sufficient to mediate light - dependent activation of the chalcone synthase ( CHS ) minimal promoter in Petroselinum crispum .", + "entities": [ + "Light regulatory unit 1", + "LRU1", + "chalcone synthase ( CHS ) minimal promoter" + ] + }, + { + "id": "5225", + "type": "gene", + "text": "Althoug RBF tended to increase after the therapy , there was no statistically significant change in RBF , GFR and cardiac output .", + "entities": [] + }, + { + "id": "5226", + "type": "gene", + "text": "Problems remain to be resolved in the area of quantitative risk assessment .", + "entities": [] + }, + { + "id": "5227", + "type": "gene", + "text": "We propose that Mnt : Max : Sin3 complexes normally function to restrict Myc : Max activities associated with cell proliferation .", + "entities": [ + "Mnt", + "Max", + "Sin3", + "Myc", + "Max" + ] + }, + { + "id": "5228", + "type": "gene", + "text": "The variable regions of vertebrate striated TnT isoforms reflect the subsequent addition and modification of genomic sequences to give rise to members of the TnT multigene family .", + "entities": [ + "TnT isoforms", + "TnT multigene family" + ] + }, + { + "id": "5229", + "type": "gene", + "text": "METHODS : Von Willebrand factor ( vWF ) and the fibrinolytic factors tissue plasminogen activator ( tPA ) , measured as tPA capacity , and plasminogen activator inhibitor 1 ( PAI - 1 ) , platelets , fibrinogen , and inflammatory markers were measured in 74 patients with active seropositive RA .", + "entities": [ + "Von Willebrand factor", + "vWF", + "tissue plasminogen activator", + "tPA", + "tPA", + "plasminogen activator inhibitor 1", + "PAI - 1", + "fibrinogen" + ] + }, + { + "id": "5230", + "type": "gene", + "text": "DNA polymerase E , DNA ligase III and a DNA structure - specific endonuclease co - purify with the five polypeptide complex .", + "entities": [ + "DNA polymerase E", + "DNA ligase III" + ] + }, + { + "id": "5231", + "type": "gene", + "text": "In vitro , Arix and NBPhox form DNA - independent multimers and exhibit cooperative binding to the DB1 regulatory element , which contains two homeodomain recognition sites .", + "entities": [ + "Arix", + "NBPhox", + "DB1 regulatory element", + "homeodomain recognition sites" + ] + }, + { + "id": "5232", + "type": "gene", + "text": "The levels of galactosyltransferase activity in sera from normal children and patients with cystic fibrosis .", + "entities": [ + "galactosyltransferase" + ] + }, + { + "id": "5233", + "type": "gene", + "text": "Paraneoplastic rheumatic syndromes .", + "entities": [] + }, + { + "id": "5234", + "type": "gene", + "text": "The amino - terminal third of the protein contains a high - mobility - group motif characteristic of DNA - binding proteins .", + "entities": [ + "high - mobility - group motif" + ] + }, + { + "id": "5235", + "type": "gene", + "text": "We analyzed data from 56 patients with Systemic Lupus Erythematosus ( SLE ) in whom renal biopsies were done systematically .", + "entities": [] + }, + { + "id": "5236", + "type": "gene", + "text": "Computer software assisted ordering ( CSAO ) was developed to integrate PN Ca : P solubility with clinical data to improve parenteral Ca and P administration .", + "entities": [] + }, + { + "id": "5237", + "type": "gene", + "text": "Convulsive seizure during a treatment with interferon alpha for chronic viral hepatitis C", + "entities": [ + "interferon alpha" + ] + }, + { + "id": "5238", + "type": "gene", + "text": "We failed to find these data to be useful in predicting the time of onset of initial seizures after acute ischemic stroke and recurrence .", + "entities": [] + }, + { + "id": "5239", + "type": "gene", + "text": "The transcription and alternative splicing of human ORL1 and GAIP are cell - type specific .", + "entities": [ + "human ORL1", + "GAIP" + ] + }, + { + "id": "5240", + "type": "gene", + "text": "The single - stranded DNA Pur alpha recognition element disrupts these complexes .", + "entities": [ + "Pur alpha recognition element" + ] + }, + { + "id": "5241", + "type": "gene", + "text": "Of 419 persons surveyed , 207 ( 49 . 4 % ) were antigen - positive with the Og4C3 assay .", + "entities": [ + "Og4C3" + ] + }, + { + "id": "5242", + "type": "gene", + "text": "Whereas the muscle isoform consists of 997 amino acids and terminates with the sequence Ala - Ile - Leu - Glu , the second isoform is 1043 amino acids in length due to the replacement of these last 4 amino acids with a 50 - amino acid sequence that contains a potential transmembrane domain followed by a consensus sequence for an N - linked glycosylation site .", + "entities": [] + }, + { + "id": "5243", + "type": "gene", + "text": "Identification and characterization of the promoter for the cytotactin gene .", + "entities": [ + "cytotactin gene" + ] + }, + { + "id": "5244", + "type": "gene", + "text": "The double - stranded RNA binding domain ( dsRBD ) is an approximately 65 amino acid motif that is found in a variety of proteins that interact with double - stranded ( ds ) RNA , such as Escherichia coli RNase III and the dsRNA - dependent kinase , PKR .", + "entities": [ + "RNase III", + "dsRNA - dependent kinase", + "PKR" + ] + }, + { + "id": "5245", + "type": "gene", + "text": "On the basis of serum alpha1AT quantitation , newborn infants may be separated into two groups , characterized respectively by concentrations above or below 150 mg % .", + "entities": [ + "serum alpha1AT" + ] + }, + { + "id": "5246", + "type": "gene", + "text": "B cell - specific mb - 1 and B29 genes encode the alpha / beta components of the BCR - associated complex in mature sIgM + B cells .", + "entities": [ + "mb - 1", + "B29 genes", + "BCR - associated complex", + "sIgM +" + ] + }, + { + "id": "5247", + "type": "gene", + "text": "Interestingly , segment nesting differentially increases the copy number of genes encoded by segment W , suggesting that the unusual genomic organization of PDVs may be directly linked to the unique functions of this virus in its obligate mutualistic association with parasitic wasps .", + "entities": [] + }, + { + "id": "5248", + "type": "gene", + "text": "Exon - intron junctions in the human and rat AdoMet decarboxylase genes were in identical positions except that exons 6 and 7 of the human gene formed a single exon in the rat gene .", + "entities": [ + "rat AdoMet decarboxylase genes" + ] + }, + { + "id": "5249", + "type": "gene", + "text": "Dual innervation of fast fibers in trunk muscles of lamprey larvae", + "entities": [] + }, + { + "id": "5250", + "type": "gene", + "text": "Model IV : primary abutments with the lateral incisor and the second molar as secondary abutments .", + "entities": [] + }, + { + "id": "5251", + "type": "gene", + "text": "Two potential regulatory sequences for DNA binding proteins were found in the non - coding 5 ' region : a HAP2 / HAP3 consensus recognition sequence at nucleotide - 154 and a BAF1 consensus recognition sequence at nucleotide - 136 .", + "entities": [ + "HAP2", + "HAP3", + "BAF1 consensus recognition sequence" + ] + }, + { + "id": "5252", + "type": "gene", + "text": "He is well , five years after relapse .", + "entities": [] + }, + { + "id": "5253", + "type": "gene", + "text": "The absorbable perisplenic mesh is an important improvement , and in some cases it may replace other techniques for arresting splenic bleeding .", + "entities": [] + }, + { + "id": "5254", + "type": "gene", + "text": "Functional characterization of a fraction identified by its activity in a second template rescue assay .", + "entities": [] + }, + { + "id": "5255", + "type": "gene", + "text": "This fraction is resistant to digestions by DNase I and RNase T1 and disappears completely upon alkali hydrolysis .", + "entities": [ + "DNase I", + "RNase T1" + ] + }, + { + "id": "5256", + "type": "gene", + "text": "The MAP kinase cascade is highly conserved in all eukaryotes and involved in numerous cellular responses .", + "entities": [ + "MAP kinase" + ] + }, + { + "id": "5257", + "type": "gene", + "text": "A .", + "entities": [] + }, + { + "id": "5258", + "type": "gene", + "text": "The results suggest that the bulbospinal micturition reflex evoked by bladder filling and L - dopa involves a descending pathway where transmission is partly mediated by spinal alpha 1 - adrenoceptors .", + "entities": [ + "spinal alpha 1 - adrenoceptors" + ] + }, + { + "id": "5259", + "type": "gene", + "text": "The cysteine - rich region of raf - 1 kinase contains zinc , translocates to liposomes , and is adjacent to a segment that binds GTP - ras .", + "entities": [ + "raf - 1 kinase", + "GTP - ras" + ] + }, + { + "id": "5260", + "type": "gene", + "text": "A comparison of the predicted amino acid sequences of the two human PKC - delta clones with the rat and mouse homologues indicated a greater degree of sequence divergence ( 89 - 90 % homology ) compared to the high degree of sequence conservation observed with other human PKC family members and their mammalian counterparts .", + "entities": [ + "human PKC - delta", + "human PKC family members" + ] + }, + { + "id": "5261", + "type": "gene", + "text": "Studies also have alluded to a relationship between the MSMR cyst and certain signs or symptoms of disease .", + "entities": [] + }, + { + "id": "5262", + "type": "gene", + "text": "These results suggest that the phenotype of XLP may result from perturbed signaling not only through SLAM , but also other cell surface molecules that utilize SAP as a signaling adaptor protein .", + "entities": [ + "SLAM", + "SAP" + ] + }, + { + "id": "5263", + "type": "gene", + "text": "Subsequently , these coordinates must be interpreted to define particular tissues and organs .", + "entities": [] + }, + { + "id": "5264", + "type": "gene", + "text": "Most patients preferred tablets to injection both on day 1 ( 313 v 200 ) and at follow up ( 373 v 104 ) .", + "entities": [] + }, + { + "id": "5265", + "type": "gene", + "text": "The epidemic occurred in a group of 26 community members ( 23 men and 3 women , mean age , 28 . 9 - - 3 years ) living and working together , who underwent acute and convalescent serologic tests for Mycoplasma pneumoniae , Legionella pneumophila , cytomegalovirus , adenovirus , Coxiella burnetii , and Chlamydia pneumoniae .", + "entities": [] + }, + { + "id": "5266", + "type": "gene", + "text": "Transformed bacterial colonies were screened for recombinant plasmids containing cDNA coding for BiP by hybrid - selected mRNA translation .", + "entities": [ + "BiP" + ] + }, + { + "id": "5267", + "type": "gene", + "text": "Branch occlusion of Heubner ' s artery , or perforators from the proximal anterior or middle cerebral arteries were the posited mechanism of infarction .", + "entities": [] + }, + { + "id": "5268", + "type": "gene", + "text": "Similarly , the N - terminal cytoplasmic domain of the latent membrane protein 2A ( LMP2A ) of the Epstein - Barr virus ( EBV ) contains a single copy of the Tyr - X - X - Leu / Ile - containing motif which could play a critical role in B cell transformation .", + "entities": [ + "latent membrane protein 2A", + "LMP2A" + ] + }, + { + "id": "5269", + "type": "gene", + "text": "Crystal structure of an oligomer of proteolytic zymogens : detailed conformational analysis of the bovine ternary complex and implications for their activation .", + "entities": [] + }, + { + "id": "5270", + "type": "gene", + "text": "As retinoic acid and thyroid hormone are frequently involved in developmental regulatory processes , it is possible that this element may be important in the process of islet cell differentiation .", + "entities": [] + }, + { + "id": "5271", + "type": "gene", + "text": "The occurrence of multiple malignancy was studied in 674 patients with hematologic malignancies who were admitted to this department during the past 10 years .", + "entities": [] + }, + { + "id": "5272", + "type": "gene", + "text": "In two - field nodal dissection , two components are included with ( modern two - field ) or without ( traditional two - field ) nodal dissection around both recurrent laryngeal nerve chains in the upper mediastinum .", + "entities": [] + }, + { + "id": "5273", + "type": "gene", + "text": "S6K2 is highly homologous to S6K1 in the core kinase and linker regulatory domains but differs from S6K1 in the N - and C - terminal regions and is differently localized primarily to the nucleus because of a C - terminal nuclear localization signal unique to S6K2 .", + "entities": [ + "S6K2", + "S6K1", + "S6K1", + "S6K2" + ] + }, + { + "id": "5274", + "type": "gene", + "text": "The coordinate increase in cyclin D1 and p21 had the effect of decreasing the specific but not absolute activity of cyclin D1 / cdk4 .", + "entities": [ + "cyclin D1", + "p21", + "cyclin D1", + "cdk4" + ] + }, + { + "id": "5275", + "type": "gene", + "text": "p53 was not involved since CSF - 1 induction of p21 was unaffected by dominant - negative p53 expression .", + "entities": [ + "p53", + "CSF - 1", + "p21", + "dominant - negative p53" + ] + }, + { + "id": "5276", + "type": "gene", + "text": "A series of amino terminal deletion mutants ( d10 , d20 , d27 , d31 , d40 , d44 , and d73 ) were compared for processing , cell surface expression , and maintenance of their biological attributes by recombinant expression of mutant genes using a plasmid vector ( pcDL - SR alpha - 296 ) in CV - 1 and HeLa cells .", + "entities": [] + }, + { + "id": "5277", + "type": "gene", + "text": "We show that LexA - GAL4 and LexA - Bicoid fusion proteins are both dependent on SNF2 , SNF5 , and SNF6 for activation of target genes containing one or multiple lexA operators .", + "entities": [ + "LexA", + "GAL4", + "LexA", + "Bicoid", + "SNF2", + "SNF5", + "SNF6", + "lexA operators" + ] + }, + { + "id": "5278", + "type": "gene", + "text": "The mutation experiments showed that the most critical sequence for the repression of PTH was 5 ' - GGGGGAGGGGAG - 3 ' ( + 1 to + 12 ) of PTHSR .", + "entities": [ + "PTH", + "PTHSR" + ] + }, + { + "id": "5279", + "type": "gene", + "text": "Number and size of silver - stained nucleoli ( Ag - NOR clusters ) in canine seminomas : correlation with histological features and tumour behaviour .", + "entities": [] + }, + { + "id": "5280", + "type": "gene", + "text": "Factor XI deficiency is a rare hereditary bleeding disorder affecting the intrinsic pathway .", + "entities": [ + "Factor XI" + ] + }, + { + "id": "5281", + "type": "gene", + "text": "Of those injuries , 143 cases were snowboard related and 158 cases were ski related .", + "entities": [] + }, + { + "id": "5282", + "type": "gene", + "text": "These data showed : that progesterone secretion is pulsatile throughout the human luteal phase , with maximum frequency in the mid - luteal phase ; that during the mid - luteal phase most subjects had progesterone levels both above and below currently accepted ovulatory thresholds ; the use of a single measurement of progesterone in the mid - luteal phase is not always a reliable indicator of ovulation ; a threshold greater than 20 nmol / l may yield an unacceptable number of false negative results .", + "entities": [] + }, + { + "id": "5283", + "type": "gene", + "text": "This study determined the arthritogenic potential of silicone gel by either mixing it with bovine collagen II ( BII ) or by injecting silicone gel alone in DA rats .", + "entities": [ + "bovine collagen II", + "BII" + ] + }, + { + "id": "5284", + "type": "gene", + "text": "Mutations in a region located 15 to 30 bp downstream from the major transcription start site that shows good homology to a sequence in the first exon of c - fos implicated as a negative regulatory element resulted in a significant increase in basal gene expression but did not affect regulation .", + "entities": [ + "c - fos" + ] + }, + { + "id": "5285", + "type": "gene", + "text": "In a control group both common carotid arteries ( CCA ) were ligated .", + "entities": [] + }, + { + "id": "5286", + "type": "gene", + "text": "To determine the effects on the pulmonary barrier of several surface active agents , a series of metered dose inhalers ( MDIs ) was prepared and used to dose aerosolized surfactant to the airways of isolated perfused rat lungs .", + "entities": [] + }, + { + "id": "5287", + "type": "gene", + "text": "During a single LAD occlusion lasting 35 minutes ( series I , n = 10 ) 9 microns TMs were infused immediately and 30 minutes after ligation , 15 microns TMs being infused after 15 - 20 minutes .", + "entities": [] + }, + { + "id": "5288", + "type": "gene", + "text": "The results presented in this report suggest that the SV40 G - C - rich sequences can function as independent RNA polymerase II transcriptional - control elements .", + "entities": [ + "RNA polymerase II" + ] + }, + { + "id": "5289", + "type": "gene", + "text": "BACKGROUND : Mitosis is regulated by MPF ( maturation promoting factor ) , the active form of Cdc2 / 28 - cyclin B complexes .", + "entities": [ + "MPF", + "maturation promoting factor", + "Cdc2 / 28", + "cyclin B" + ] + }, + { + "id": "5290", + "type": "gene", + "text": "There was an increase in protein binding onto this element only after peptide treatment .", + "entities": [] + }, + { + "id": "5291", + "type": "gene", + "text": "Of its gene products , E6 binds to and inactivates p53 tumor suppressor protein by ubiquitin / proteasome - dependent degradation .", + "entities": [ + "E6", + "p53 tumor suppressor protein", + "ubiquitin" + ] + }, + { + "id": "5292", + "type": "gene", + "text": "Arnt3 mRNA was expressed in brain , skeletal muscle , 13 . 5 - day embryos , and P19 cells treated with retinoic acid .", + "entities": [ + "Arnt3 mRNA" + ] + }, + { + "id": "5293", + "type": "gene", + "text": "G .", + "entities": [] + }, + { + "id": "5294", + "type": "gene", + "text": "Eight of the non - acceptable inlays / onlays and five of the direct restorations were replaced , while the other ones were repaired with resin composite .", + "entities": [] + }, + { + "id": "5295", + "type": "gene", + "text": "Two - dimensional phosphotryptic analyses indicate that phosphorylation on Ser - 12 and Ser - 48 in unstimulated cells is associated with the ability of overexpressed pp60c - src to potentiate beta - adrenergic signalling .", + "entities": [ + "pp60c - src" + ] + }, + { + "id": "5296", + "type": "gene", + "text": "Importantly , in HeLa and 293 cells , endogenous and transfected I kappaB alpha coimmunoprecipitated with Myc - tagged or endogenous Dlc - 1 .", + "entities": [ + "I kappaB alpha", + "Myc", + "Dlc - 1" + ] + }, + { + "id": "5297", + "type": "gene", + "text": "Recipients with acute leukaemia in first remission or chronic myeloid leukaemia in first chronic phase were analysed as good risk , and those beyond these stages , as poor risk patients .", + "entities": [] + }, + { + "id": "5298", + "type": "gene", + "text": "In transient cotransfections E1A could induce the activity of the p53 promoter to a high level ; 12S E1A was threefold as efficient as 13S E1A in this activity , and YY1 bound to the composite element was shown to mediate 55 % of this induction .", + "entities": [ + "E1A", + "p53 promoter", + "12S E1A", + "13S E1A", + "YY1" + ] + }, + { + "id": "5299", + "type": "gene", + "text": "It suggests a sequence of surgical planning that can prevent them and also offers ways of dealing with the problems should they occur .", + "entities": [] + }, + { + "id": "5300", + "type": "gene", + "text": "The parameters of nonspecific humoral immunity - - serum immunoglobulins and immune complexes - - were evaluated in irradiated group of patients with uterine cervix carcinoma ( Stages IIB and IIIB ) , during one year follow up .", + "entities": [ + "serum immunoglobulins" + ] + }, + { + "id": "5301", + "type": "gene", + "text": "The HGF - induced cell motility was mimicked by 12 - 0 - tetradecanoyl - phorbol - 13 - acetate , a protein kinase C - activating phorbol ester , but not by Ca2 + ionophore .", + "entities": [ + "HGF", + "protein kinase C" + ] + }, + { + "id": "5302", + "type": "gene", + "text": "Group I consisted of six noncholestatic patients ; group II consisted of nine mildly cholestatic patients with mild hepatic impairment ( conjugated bilirubin , 47 mumol liter - 1 ; alkaline phosphatase , 280 IU liter - 1 ; gamma - glutamyltranspeptidase , 190 IU liter - 1 ) ; group III consisted of six benign intrahepatic cholestatic patients with high isolated conjugated hyperbilirubinemia ( 98 . 1 mumol liter - 1 ) .", + "entities": [ + "alkaline phosphatase", + "gamma - glutamyltranspeptidase" + ] + }, + { + "id": "5303", + "type": "gene", + "text": "It has a grave prognosis with > 70 % mortality in 3 months , despite mechanical ventilation .", + "entities": [] + }, + { + "id": "5304", + "type": "gene", + "text": "Mortality on the last ranch was particularly severe among certain segregated groups of turkeys that included toms , heavier birds , and birds undergoing a stressful event such as artificial insemination .", + "entities": [] + }, + { + "id": "5305", + "type": "gene", + "text": "The promoter segment was inactive when introduced into the rat glioma cell line C6B4 , the rat submandibular cell line RSMT - A5 , and the rat pancreatic beta cell line RIN - 5AH , all of which do not express the endogenous alpha2c - AR gene .", + "entities": [ + "alpha2c - AR gene" + ] + }, + { + "id": "5306", + "type": "gene", + "text": "Thus , the synergistic effects of HNF - 1beta and the GR on dexamethasone - stimulated promoter activity require that they are bound to the HNF - 1 site and the GRE , respectively , and may involve protein - protein interactions between the transcription factors , or between them and the basal transcription machinery or a steroid receptor coactivator .", + "entities": [ + "HNF - 1beta", + "GR", + "HNF - 1 site", + "steroid receptor coactivator" + ] + }, + { + "id": "5307", + "type": "gene", + "text": "These exons were identified by cloning and sequencing cDNAs obtained by polymerase chain reaction amplification of a fibroblast cDNA library .", + "entities": [] + }, + { + "id": "5308", + "type": "gene", + "text": "The kinetics of kinase activity within these complexes compared to CheA alone indicate approximately a 50 % decrease in the KM for ATP and a 100 - fold increase in the Vmax .", + "entities": [ + "CheA" + ] + }, + { + "id": "5309", + "type": "gene", + "text": "Molecular neurochemistry of addictive drugs .", + "entities": [] + }, + { + "id": "5310", + "type": "gene", + "text": "The 5 - year overall survival ( OS ) and progression - free survival ( PFS ) rates were 58 . 9 % and 55 . 4 % for arm A and 44 . 5 % and 41 . 3 % for arm B ( P = . 007 and P = . 02 ) , respectively .", + "entities": [] + }, + { + "id": "5311", + "type": "gene", + "text": "The effects of chlordiazepoxide ( 2 . 5 - 15 . 0mg / kg ) , a full benzodiazepine receptor agonist , and bretazenil ( 5 . 0 - 30 . 0mg / kg ) , a partial benzodiazepine receptor agonist , were examined in the murine elevated plus - maze paradigm .", + "entities": [ + "benzodiazepine receptor", + "benzodiazepine receptor" + ] + }, + { + "id": "5312", + "type": "gene", + "text": "Various assays demonstrate promoter activity in this sequence that reproduces the normal control of E2F2 expression during a growth stimulation .", + "entities": [ + "E2F2" + ] + }, + { + "id": "5313", + "type": "gene", + "text": "Respondents who lived with a spouse / partner only were less likely to have an unfavorable BMI status than people in the other two groups .", + "entities": [] + }, + { + "id": "5314", + "type": "gene", + "text": "This phosphorylation can be catalyzed by a break - ended double - stranded DNA - activated protein kinase activity from the sea urchin nucleus in vitro .", + "entities": [] + }, + { + "id": "5315", + "type": "gene", + "text": "Carnitine palmitoyltransferase ( CPT ) II deficiency is the most common inherited disorder of lipid metabolism affecting skeletal muscle .", + "entities": [ + "Carnitine palmitoyltransferase ( CPT ) II" + ] + }, + { + "id": "5316", + "type": "gene", + "text": "We show here that this difference is due to the presence of a Mot3 binding site in OpA .", + "entities": [ + "Mot3 binding site", + "OpA" + ] + }, + { + "id": "5317", + "type": "gene", + "text": "We studied the human vestibulo - ocular reflex ( VOR ) in response to head ' impulses ' : brief , unpredictable , passive , high - acceleration ( up to 4000 degrees / s2 ) , low - amplitude ( 20 - 30 degrees ) head rotations .", + "entities": [] + }, + { + "id": "5318", + "type": "gene", + "text": "Upstream activating sequences ( UASs ) derived from known Ste12p - dependent genes have previously been characterized to require either multiple PREs or a single PRE coupled to a binding site for a second protein .", + "entities": [ + "Ste12p" + ] + }, + { + "id": "5319", + "type": "gene", + "text": "This article will briefly review the published data on the morphology , function , and biochemistry of the normal renal medulla and the pathology associated with RPN , together with the secondary changes which give rise to cortical degeneration or epithelial carcinoma .", + "entities": [] + }, + { + "id": "5320", + "type": "gene", + "text": "The PI3K _ 68D cDNA encodes a protein of 210 kDa , which lacks sequences implicated in linking p110 PI 3 - kinases to p85 adaptor proteins , but contains an amino - terminal proline - rich sequence , which could bind to SH3 domains , and a carboxy - terminal C2 domain .", + "entities": [ + "PI3K _ 68D cDNA", + "PI 3 - kinases", + "p85 adaptor proteins", + "SH3 domains", + "C2" + ] + }, + { + "id": "5321", + "type": "gene", + "text": "The upTRE binds more T3R homodimers and less T3R - RXR heterodimers than the dnTRE , and T3 more readily facilitates heterodimer binding to the dn - than to the upTRE .", + "entities": [ + "T3R homodimers", + "T3R", + "RXR" + ] + }, + { + "id": "5322", + "type": "gene", + "text": "The prevalence of opportunistic infection among surviving AIDS patients and the probability of being in tumour response following cancer therapy conditional on being alive are two examples of such functions .", + "entities": [] + }, + { + "id": "5323", + "type": "gene", + "text": "Glutamic acid in a dose of 1 / 100 of the LD50 was injected in the form of sodium salt into male and female Wistar rats for 7 days after 8 - and 12 - day injections of dexazone .", + "entities": [] + }, + { + "id": "5324", + "type": "gene", + "text": "Foxp1 and Foxp2 are expressed at high levels in the lung as early as E12 . 5 of mouse development with Foxp2 expression restricted to the airway epithelium .", + "entities": [ + "Foxp1", + "Foxp2", + "Foxp2" + ] + }, + { + "id": "5325", + "type": "gene", + "text": "Cooperative dimerization of paired class homeo domains on DNA .", + "entities": [ + "paired" + ] + }, + { + "id": "5326", + "type": "gene", + "text": "In spite of this and other complications of corticosteroids , she made a full recovery from the fungal infection following treatment with amphotericin B and surgical excision of the lung abscess .", + "entities": [] + }, + { + "id": "5327", + "type": "gene", + "text": "Constructs designed and expressed were E2L1 ( 1 - 98 ) , E2L1 . H1 ( 1 - 128 ) , E2L2 ( 120 - 233 ) , E2H1 . L2 ( 98 - 233 ) , and E2L1 . H1 . L2 ( 1 - 233 ) , where numbers in parentheses give the amino acid sequence for the portions of the E2 component incorporated into a construct .", + "entities": [ + "E2L1 ( 1 - 98 )", + "E2L1 . H1 ( 1 - 128 )", + "E2L2 ( 120 - 233 )", + "E2H1 . L2 ( 98 - 233 )", + "E2L1 . H1 . L2 ( 1 - 233 )", + "E2" + ] + }, + { + "id": "5328", + "type": "gene", + "text": "Lipiodol was covalently conjugated with EDTB .", + "entities": [] + }, + { + "id": "5329", + "type": "gene", + "text": "After measuring baseline Vmca at a partial pressure of carbon dioxide in arterial blood ( PaCO2 ) of 37 . 7 + / - 4 . 5 mmHg ( mean + / - SD ) , measurements were repeated at a PaCO of 44 . 2 + / - 3 . 8 mmHg , and the carbon dioxide reactivity ( absolute value : cm x s ( - 1 ) x mmHg ( - 1 ) ; relative value : percentage of baseline Vmca / mmHg ) was calculated .", + "entities": [] + }, + { + "id": "5330", + "type": "gene", + "text": "GAP JUNCTIONS IN THE BRAIN : PREFACE .", + "entities": [] + }, + { + "id": "5331", + "type": "gene", + "text": "Enhanced period - peak analysis of electro - encephalograms using a fast sinc function .", + "entities": [] + }, + { + "id": "5332", + "type": "gene", + "text": "In this paper , we report a detailed study of the structure and the functional role of the MalT binding sites located in the adjacent and divergent pulAp and pulCp promoters .", + "entities": [ + "MalT binding sites", + "pulAp", + "pulCp promoters" + ] + }, + { + "id": "5333", + "type": "gene", + "text": "The standard method for calculating the composite score on the S - B IV excludes subtests with a raw score of 0 , which overestimates cognitive functioning in young biologically high risk children .", + "entities": [] + }, + { + "id": "5334", + "type": "gene", + "text": "We conclude that for mono - intronic precursors in which there is only one choice of splice sites , most of the exon sequences are not mechanistically involved in the splicing process .", + "entities": [] + }, + { + "id": "5335", + "type": "gene", + "text": "Relative to coherent control words ( e . g . , quick ) , these discourse - dependent semantic anomalies elicited a large N400 effect that began at about 200 to 250 msec after word onset .", + "entities": [] + }, + { + "id": "5336", + "type": "gene", + "text": "The gene lac - 1 , encoding the enzyme laccase , is the best characterized of a number of genes in the chestnut blight fungus , Cryphonectria parasitica , that are repressed by hypoviruses , a group of virulence - attenuating mycoviruses .", + "entities": [ + "gene lac - 1", + "laccase" + ] + }, + { + "id": "5337", + "type": "gene", + "text": "lac - 1 has also been shown to be transcriptionally activated by low concentrations of the translational inhibitor cycloheximide ( CHX ) and by the immunosuppressant cyclosporin A .", + "entities": [ + "lac - 1" + ] + }, + { + "id": "5338", + "type": "gene", + "text": "Escherichia coli JRG582 is an ampD ampE deletion derivative of strain HfrH and accordingly it is derepressed for expression of the cloned inducible beta - lactamase gene of Citrobacter freundii , carried on plasmid pNU305 .", + "entities": [ + "ampE", + "beta - lactamase gene" + ] + }, + { + "id": "5339", + "type": "gene", + "text": "Consistent with this possibility , a non - MBD region of Bin1 was sufficient to recruit a repression function to DNA that was unrelated to histone deacetylase .", + "entities": [ + "MBD", + "Bin1", + "histone deacetylase" + ] + }, + { + "id": "5340", + "type": "gene", + "text": "A haemolytic enterotoxigenic strain of E . coli ( O149 : K88 : H10 ) was regularly recovered from piglets with PWD while rotavirus was demonstrated on a number of occasions .", + "entities": [] + }, + { + "id": "5341", + "type": "gene", + "text": "Glycogen utilization was increased , but tissue levels of creatine phosphate , ATP , and lactate were similar to those in hearts receiving normal flow .", + "entities": [] + }, + { + "id": "5342", + "type": "gene", + "text": "In addition , we sought to test the hypothesis that , when equal volumes are administered intrathecally , significant differences exist in the potential to three commonly used anesthetic solutions to induce sensory impairment .", + "entities": [] + }, + { + "id": "5343", + "type": "gene", + "text": "Resolution of thermographic asymmetry and / or decrease in Delta T was demonstrated in approximately 81 % of the post - treatment population .", + "entities": [] + }, + { + "id": "5344", + "type": "gene", + "text": "Video images of the nostrils were captured and then analyzed for area , perimeter , centroid , principal axis , moments about the major and minor axes ( I11 , I22 ) , anisometry , bulkiness , lateral offset , internostril angle , and rotational angle .", + "entities": [] + }, + { + "id": "5345", + "type": "gene", + "text": "In this report we describe the isolation of a Fab fragment ( Fab A8 ) showing a high relative affinity for the receptor ( 0 . 5 nM ) .", + "entities": [ + "Fab fragment", + "Fab A8" + ] + }, + { + "id": "5346", + "type": "gene", + "text": "Reverse transcriptase - polymerase chain reaction ( RT - PCR ) was performed using eyestalk complementary DNA of the sand shrimp Metapenaeus ensis .", + "entities": [ + "Reverse transcriptase", + "RT" + ] + }, + { + "id": "5347", + "type": "gene", + "text": "We show that other cdc33 mutants also arrest in G1 .", + "entities": [ + "cdc33 mutants" + ] + }, + { + "id": "5348", + "type": "gene", + "text": "In Klinefelter ' s syndrome ( 47XXY ) , serum testosterone levels are at the lower end of the normal range and dihydrotestosterone levels are low .", + "entities": [] + }, + { + "id": "5349", + "type": "gene", + "text": "The results indicate that the carbon - perfused areas and MBF in the liver , renal cortex , spleen , and small intestinal serosa ( only MBF ) increased significantly 5 h after CLP .", + "entities": [] + }, + { + "id": "5350", + "type": "gene", + "text": "Abnormal urinary coproporphyrin levels in patients infected by hepatitis C virus with or without human immunodeficiency virus .", + "entities": [] + }, + { + "id": "5351", + "type": "gene", + "text": "These data will help us to better detail the CXCR4 structural requirements exhibited by different HIV - 1 strains and will direct further mutagenesis efforts aimed at better defining the domains in CXCR4 involved in the HIV - 1 Env - mediated fusion process .", + "entities": [ + "CXCR4", + "CXCR4", + "Env" + ] + }, + { + "id": "5352", + "type": "gene", + "text": "Displacement thresholds of peripheral sites in monocular human vision were obtained .", + "entities": [] + }, + { + "id": "5353", + "type": "gene", + "text": "This protein with a hydrophobic amino terminus appears to be a secreted protein .", + "entities": [] + }, + { + "id": "5354", + "type": "gene", + "text": "Solitary thyroid nodule .", + "entities": [] + }, + { + "id": "5355", + "type": "gene", + "text": "In this situation the convlusion threshold for the 8 substances is as follows : pethidine 20 mg . kg - 1 I . V . , piritramide 30 , morphine 180 , phenoperidine 4 , R 39 209 5 , fentanyl 4 , sufentanil 4 and R 34 995 10 mg . kg - 1 I . V .", + "entities": [] + }, + { + "id": "5356", + "type": "gene", + "text": "Positron emission tomography radioligands for dopamine transporters and studies in human and nonhuman primates .", + "entities": [ + "dopamine transporters" + ] + }, + { + "id": "5357", + "type": "gene", + "text": "After 2 min of dobutamine injection , or after 20 min of pimobendan injection , the myocardium was removed , and used for determination of the tissue levels of metabolites of energy and carbohydrate metabolism .", + "entities": [] + }, + { + "id": "5358", + "type": "gene", + "text": "In this study , we sought to identify mechanisms that could account for the antimitogenic effects of IL - 4 .", + "entities": [ + "IL - 4" + ] + }, + { + "id": "5359", + "type": "gene", + "text": "Although E2FBP1 lacks the transactivation domain , it stimulates E2F site - dependent transcription in cooperation with E2F - 1 .", + "entities": [ + "E2FBP1", + "E2F", + "E2F - 1" + ] + }, + { + "id": "5360", + "type": "gene", + "text": "In vitro transcription results indicate that this 5 ' structure functions in the attenuation mechanism , since deletion of the stem - loop caused an increase in transcription readthrough .", + "entities": [] + }, + { + "id": "5361", + "type": "gene", + "text": "Serum IgG was initially elevated in 6 patients .", + "entities": [ + "IgG" + ] + }, + { + "id": "5362", + "type": "gene", + "text": "RESULTS : Neither basal FSH level nor stimulated FSH level alone were statistically significant predictors of IVF success ; however , no patient with a day 3 FSH level > 11 . 1 mIU / ml or a stimulated day 10 FSH level > 13 . 5 mIU / ml conceived and carried a pregnancy .", + "entities": [ + "FSH", + "FSH", + "FSH", + "FSH" + ] + }, + { + "id": "5363", + "type": "gene", + "text": "Using an oligomer duplex 5 ' - A ( GGGTTA ) ( 5 ) - 3 ' / 5 ' - ( TAACCC ) ( 5 ) T - 3 ' as a template - primer , we show that both the Klenow fragment of Escherichia coli DNA polymerase I and HIV reverse transcriptase could expand telomere DNA sequences as well , giving products greater than the size of the template DNA .", + "entities": [ + "Klenow fragment of Escherichia coli DNA polymerase I", + "HIV reverse transcriptase" + ] + }, + { + "id": "5364", + "type": "gene", + "text": "The genomic structure of the human SPEC1 gene reveals complex splicing and close promoter proximity to the AF1q translocation gene .", + "entities": [ + "human SPEC1 gene", + "AF1q translocation gene" + ] + }, + { + "id": "5365", + "type": "gene", + "text": "DNA sequence analysis has confirmed that this mutation affects the C - terminal region of the alpha subunit , changing a leucine residue at position 290 to a histidine ( rpoAL290H ) .", + "entities": [ + "rpoAL290H" + ] + }, + { + "id": "5366", + "type": "gene", + "text": "202 - 8 .", + "entities": [] + }, + { + "id": "5367", + "type": "gene", + "text": "The location and approximate length of the intron are conserved in both the tomato and Arabidopsis genes , with the intron separating the ' nose ' region ( encoded by exon 1 ) from the central globular domain ( exon 2 ) .", + "entities": [] + }, + { + "id": "5368", + "type": "gene", + "text": "Binding of serum response factor to CArG box sequences is necessary but not sufficient to restrict gene expression to arterial smooth muscle cells .", + "entities": [ + "serum response factor" + ] + }, + { + "id": "5369", + "type": "gene", + "text": "These findings suggest that intraarterial neoadjuvant chemotherapy should be effective on advanced cervical cancer .", + "entities": [] + }, + { + "id": "5370", + "type": "gene", + "text": "With each of the three pairs of isolates ( case and suspicious case ) , identical IS6110 banding patterns were found suggesting identical MTB strains .", + "entities": [] + }, + { + "id": "5371", + "type": "gene", + "text": "To study a possible functional role of this putative chicken ICS , an oligonucleotide spanning the upstream sequences of the BF - IV gene ( - 174 / - 194 ) was cloned singly or in multiple copies before the herpes TK promoter controlling the chloramphenicol acetyl transferase ( CAT ) gene ( pBLCAT2 ) .", + "entities": [ + "ICS", + "BF - IV gene", + "TK promoter", + "chloramphenicol acetyl transferase", + "CAT", + "pBLCAT2" + ] + }, + { + "id": "5372", + "type": "gene", + "text": "Reye ' s syndrome : reports of 7 cases in the period 1982 - 1987", + "entities": [] + }, + { + "id": "5373", + "type": "gene", + "text": "Abnormal characteristics and verticillation in Platynothrus peltifer", + "entities": [] + }, + { + "id": "5374", + "type": "gene", + "text": "All stimulations were down - regulated with GnRH - a commenced on day 21 in a long protocol before gonadotropin stimulation .", + "entities": [ + "GnRH - a", + "gonadotropin" + ] + }, + { + "id": "5375", + "type": "gene", + "text": "Here we demonstrate that native MRCK exists in high - molecular - weight complexes .", + "entities": [ + "native MRCK" + ] + }, + { + "id": "5376", + "type": "gene", + "text": "In addition to its effect in augmenting the neutrophil response to eccentric exercise , vitamin E causes a greater increase in circulating creatine kinase activity , perhaps indicating increased skeletal muscle repair .", + "entities": [ + "creatine kinase" + ] + }, + { + "id": "5377", + "type": "gene", + "text": "Based on subcellular fractionation , the 47 - kDa P - CIP2 protein is mostly cytosolic .", + "entities": [ + "47 - kDa P - CIP2 protein" + ] + }, + { + "id": "5378", + "type": "gene", + "text": "These motifs include a Chi motif and a Chi - like element previously found in the recombination hotspot region of the Bcl - 2 proto - oncogene and close to chromosomal breakpoints in T - ALL lines .", + "entities": [ + "Bcl - 2 proto - oncogene" + ] + }, + { + "id": "5379", + "type": "gene", + "text": "The revitalization of surgery for Parkinson ' s disease ( PD ) has fueled discussion about the best methodology to define the target .", + "entities": [] + }, + { + "id": "5380", + "type": "gene", + "text": "A transformation - competent mutant , like the wild - type E5 protein , bound the receptor and induced receptor tyrosine phosphorylation and down - regulation .", + "entities": [ + "wild - type E5 protein" + ] + }, + { + "id": "5381", + "type": "gene", + "text": "We suppose that this injection speed ( 0 . 1 - 0 . 2 ml . s - 1 ) is suitable for spinal anesthesia .", + "entities": [] + }, + { + "id": "5382", + "type": "gene", + "text": "The differences in the CPIgG , CRP , and fibrinogen levels in patients who were diagnosed with ACS versus those who were not ( non - ACS ) were evaluated .", + "entities": [ + "CPIgG", + "CRP", + "fibrinogen" + ] + }, + { + "id": "5383", + "type": "gene", + "text": "The androgen receptor ( AR ) amino - terminus imposes androgen - specific regulation of AR gene expression via an exonic enhancer .", + "entities": [ + "androgen receptor", + "AR", + "AR gene" + ] + }, + { + "id": "5384", + "type": "gene", + "text": "Effect of trauma on plasma glucagon and insulin concentrations in sheep .", + "entities": [ + "plasma glucagon", + "insulin" + ] + }, + { + "id": "5385", + "type": "gene", + "text": "In addition , npm3 , which is usually coactivated with fgf8 by MMTV insertion , was not up - regulated by androgens in SC - 3 cells .", + "entities": [ + "npm3", + "fgf8" + ] + }, + { + "id": "5386", + "type": "gene", + "text": "The ratio of P - 31 NMR - S derived inorganic phosphates [ Pi ] to phosphocreatine [ PCr ] was significantly greater at rest in LVH baboons [ 0 . 53 + / - 0 . 06 versus controls = 0 . 41 + / - 0 . 17 ; P less than 0 . 05 ] .", + "entities": [] + }, + { + "id": "5387", + "type": "gene", + "text": "The importance of temporal factors on the presence and severity of ethanol withdrawal signs in the rat was quantified using rating scale , tremor , and acoustic startle paradigms .", + "entities": [] + }, + { + "id": "5388", + "type": "gene", + "text": "Using the postural and force data as input to a 3 - D biomechanical model , the lumbosacral spinal compression was calculated .", + "entities": [] + }, + { + "id": "5389", + "type": "gene", + "text": "Ultrastructure of the heart muscle in experimental myocardial infarct following physical training", + "entities": [] + }, + { + "id": "5390", + "type": "gene", + "text": "Gimpl , F .", + "entities": [] + }, + { + "id": "5391", + "type": "gene", + "text": "All radiologists using the machine found that the reporting terminal was simple to operate , but found that reporting abnormalities caused an increased effort and took a longer time .", + "entities": [] + }, + { + "id": "5392", + "type": "gene", + "text": "The titer of TSH binding inhibitor immunoglobulin ( TBII ) , which had been 8 . 6 % at initial presentation , rose to 14 . 9 % in 2 weeks .", + "entities": [ + "TSH binding inhibitor immunoglobulin", + "TBII" + ] + }, + { + "id": "5393", + "type": "gene", + "text": "We demonstrate that a VT + peptide was specifically phosphorylated by protein kinase C ( PKC ) in vitro , but not by protein kinase A ( PKA ) .", + "entities": [ + "protein kinase C", + "PKC", + "protein kinase A", + "PKA" + ] + }, + { + "id": "5394", + "type": "gene", + "text": "The ' field of stress ' of the supervisory nurse", + "entities": [] + }, + { + "id": "5395", + "type": "gene", + "text": "Body temperature and overall conductance in the cold appear to be more variable in P .", + "entities": [] + }, + { + "id": "5396", + "type": "gene", + "text": "s . campbelli than in nominative sp .", + "entities": [] + }, + { + "id": "5397", + "type": "gene", + "text": "Genomic structure and chromosomal location of the mouse pre - T - cell receptor alpha gene .", + "entities": [ + "mouse pre - T - cell receptor alpha gene" + ] + }, + { + "id": "5398", + "type": "gene", + "text": "These sequence analyses suggest that xIRS - u is a novel member of the IRS family rather than a Xenopus homolog of an existing member .", + "entities": [ + "xIRS - u", + "IRS family" + ] + }, + { + "id": "5399", + "type": "gene", + "text": "The functional mature domain of pediocin AcH ( Lys + 1 to Cys + 44 ) is targeted into the E . coli sec machinery and secreted to the periplasm in active form when fused in frame to the COOH terminus of the secretory protein maltose - binding protein ( MBP ) .", + "entities": [ + "pediocin AcH ( Lys + 1 to Cys + 44 )", + "secretory protein maltose - binding protein", + "MBP" + ] + }, + { + "id": "5400", + "type": "gene", + "text": "To search for genes that interact with the SLK1 - SLT2 pathway , a synthetic lethal suppression screen was carried out .", + "entities": [ + "SLK1", + "SLT2" + ] + }, + { + "id": "5401", + "type": "gene", + "text": "This study assesses the feasibility and toxicity of adoptive immunotherapy with tumor infiltrating lymphocytes and recombinant interleukin - 2 in 29 patients who underwent resection for stage III non - small - cell lung cancer .", + "entities": [ + "recombinant interleukin - 2" + ] + }, + { + "id": "5402", + "type": "gene", + "text": "Taken together , our results demonstrate that CAP1 is involved in multidrug resistance and oxidative stress response in C . albicans .", + "entities": [ + "CAP1" + ] + }, + { + "id": "5403", + "type": "gene", + "text": "These observations of elevated serum lipase and serum CA 19 - 9 in Sjogren ' s syndrome without evidence of malignancy may reflect pancreatic involvement in this disorder .", + "entities": [ + "serum lipase", + "CA 19 - 9" + ] + }, + { + "id": "5404", + "type": "gene", + "text": "Identification of a spliced gene from Kaposi ' s sarcoma - associated herpesvirus encoding a protein with similarities to latent membrane proteins 1 and 2A of Epstein - Barr virus .", + "entities": [ + "latent membrane proteins 1 and 2A of Epstein - Barr virus" + ] + }, + { + "id": "5405", + "type": "gene", + "text": "Mutational studies revealed that it was the homeodomain binding site II sequence that was required for this regulation .", + "entities": [ + "homeodomain binding site II sequence" + ] + }, + { + "id": "5406", + "type": "gene", + "text": "We examined Akt activation in Lyn - , Syk - and Btk - deficient DT40 cells and B cells from Lyn ( - / - ) mice .", + "entities": [ + "Akt", + "Lyn", + "Syk", + "Btk", + "Lyn ( - / - )" + ] + }, + { + "id": "5407", + "type": "gene", + "text": "The latent periods from the antral exclusion to the occurrence of anastomotic ulcers after a subtotal gastrectomy with Billroth ' s type II reconstruction varied from a few days to 19 years , with an average of 2 . 8 years .", + "entities": [] + }, + { + "id": "5408", + "type": "gene", + "text": "TFEC , a basic helix - loop - helix protein , forms heterodimers with TFE3 and inhibits TFE3 - dependent transcription activation .", + "entities": [ + "TFEC", + "basic helix - loop - helix protein", + "TFE3", + "TFE3" + ] + }, + { + "id": "5409", + "type": "gene", + "text": "Conjugated estrogens shorten bleeding time in uraemia : a possible role of serotonin ?", + "entities": [] + }, + { + "id": "5410", + "type": "gene", + "text": "Through two novel mechanisms , Arf inhibits the oncoprotein Hdm2 , a negative regulator of p53 .", + "entities": [ + "Arf", + "oncoprotein Hdm2", + "p53" + ] + }, + { + "id": "5411", + "type": "gene", + "text": "Definite JPsA ( 24 patients ) was defined as arthritis associated , but not necessarily coincident , with a typical psoriatic rash , or arthritis plus at least 3 of 4 minor criteria : dactylitis , nail pitting , psoriasis - like rash , or family history of psoriasis .", + "entities": [] + }, + { + "id": "5412", + "type": "gene", + "text": "E1 , a DNA helicase , collaborates with the HPV E2 protein in ori - dependent replication .", + "entities": [ + "E1", + "DNA helicase", + "HPV E2 protein" + ] + }, + { + "id": "5413", + "type": "gene", + "text": "Serum creatine kinase ( SCK ) was measured in ten subjects in the laboratory before and after the performance of bicycle ergometry and a lifting task .", + "entities": [ + "Serum creatine kinase", + "SCK" + ] + }, + { + "id": "5414", + "type": "gene", + "text": "However , the requirement of rev3 for the production of G . C - - > T . A transversions by the rad18 mutator , which induces only these substitutions , was similar to that for rad6 - mediated G . C - - > T . A transversion .", + "entities": [ + "rev3", + "rad18 mutator", + "rad6" + ] + }, + { + "id": "5415", + "type": "gene", + "text": "We cloned a DNA fragment encoding the N - terminal part of a protein with significant similarity to members of the LysR family of transcriptional regulators ( LTTRs ) .", + "entities": [ + "LysR family of transcriptional regulators", + "LTTRs" + ] + }, + { + "id": "5416", + "type": "gene", + "text": "The biology of Hyostrongylus ruidus .", + "entities": [] + }, + { + "id": "5417", + "type": "gene", + "text": "A limited sampling strategy was used based on a bayesian parameter estimation algorithm that is part of the ADAPT II software package .", + "entities": [] + }, + { + "id": "5418", + "type": "gene", + "text": "A P22 R17 derivative with an OcRNA site ( P22 R17 [ A ( - 10 ) U ] ) develops lytically following infection of these strains .", + "entities": [] + }, + { + "id": "5419", + "type": "gene", + "text": "Transcriptional control of a nuclear gene encoding a mitochondrial fatty acid oxidation enzyme in transgenic mice : role for nuclear receptors in cardiac and brown adipose expression .", + "entities": [] + }, + { + "id": "5420", + "type": "gene", + "text": "These data indicate that phosphorylation of M protein at the major in vivo sites is not essential for virus assembly .", + "entities": [ + "M protein" + ] + }, + { + "id": "5421", + "type": "gene", + "text": "BACKGROUND : Hepatic encephalopathy is a neuropsychiatric syndrome associated with acute liver failure , chronic parenchymal liver disease or portal systemic anastomosis .", + "entities": [] + }, + { + "id": "5422", + "type": "gene", + "text": "The reconstituted RNA polymerases containing the mutant alpha subunits were examined for their response to transcription activation by cAMP - CRP and the rrnBP1 UP element .", + "entities": [ + "RNA polymerases", + "cAMP - CRP", + "rrnBP1 UP element" + ] + }, + { + "id": "5423", + "type": "gene", + "text": "The incidence of cardiac death ( one per group ) , Q wave MI ( propofol , n = 7 ; midazolam , n = 3 ; P = 0 . 27 ) , or non Q wave MI ( propofol , n = 16 ; midazolam , n = 18 ; P = 0 . 81 ) did not differ between treatment groups .", + "entities": [] + }, + { + "id": "5424", + "type": "gene", + "text": "METHODS : All these 30 non - responders received an extra dose of the same vaccine 2 months after primary immunization and a booster dose with a yeast - derived vaccine 6 years later .", + "entities": [] + }, + { + "id": "5425", + "type": "gene", + "text": "A transgenic complementation assay was used to test whether NIa supplied in trans could rescue amplification - defective viral genomes encoding altered NIa proteins .", + "entities": [ + "NIa", + "NIa proteins" + ] + }, + { + "id": "5426", + "type": "gene", + "text": "Plasmids pAMS12 , pAMS13 and pAMS14 were transformed into a laboratory strain of Saccharomyces cerevisiae , whereas pAMS15 was stably introduced into two commercial wine yeast strains .", + "entities": [] + }, + { + "id": "5427", + "type": "gene", + "text": "The sequence analysis of both products of individual phi 80 site - specific recombination events in vivo shows that recombination with a secondary attachment ( att ) site generates several different novel joints at the mismatched position : one recombination event resulted in a single base - pair deletion and two other recombination events resulted in two different single base - pair substitutions .", + "entities": [] + }, + { + "id": "5428", + "type": "gene", + "text": "Second , plasmid - derived transgenes and gene targeting of the endogenous Hnf3g gene locus were used to demonstrate that the 3 ' - flanking region of the gene is necessary and sufficient to direct reporter gene expression in liver , pancreas , stomach and small intestine .", + "entities": [ + "endogenous Hnf3g gene locus" + ] + }, + { + "id": "5429", + "type": "gene", + "text": "High plasma concentrations of soluble E - selectin were closely associated with multiple - organ dysfunction and death .", + "entities": [ + "E - selectin" + ] + }, + { + "id": "5430", + "type": "gene", + "text": "Paralemmin is also phosphorylated , and its mRNA is differentially spliced in a tissue - specific and developmentally regulated manner .", + "entities": [ + "Paralemmin" + ] + }, + { + "id": "5431", + "type": "gene", + "text": "After hemodynamic stabilization , the goal of therapy is to diminish the chance that an ulcer will continue to bleed or will rebleed .", + "entities": [] + }, + { + "id": "5432", + "type": "gene", + "text": "8 % ( 95 % CI , 21 . 3 - 44 . 3 % ) .", + "entities": [] + }, + { + "id": "5433", + "type": "gene", + "text": "Thus , the inhibition of pepsin in human gastric juice does not appear to have a major influence on the healing of duodenal ulcer .", + "entities": [ + "pepsin" + ] + }, + { + "id": "5434", + "type": "gene", + "text": "Using purified recombinant HMG I , we have identified several high - affinity binding sites which overlap important transcription factor binding sites .", + "entities": [ + "recombinant HMG I" + ] + }, + { + "id": "5435", + "type": "gene", + "text": "Stable expression of truncated inositol 1 , 4 , 5 - trisphosphate receptor subunits in 3T3 fibroblasts .", + "entities": [ + "truncated inositol 1 , 4 , 5 - trisphosphate receptor subunits" + ] + }, + { + "id": "5436", + "type": "gene", + "text": "Therefore , vitamin D3 analogues have a substantial antipsoriatic effect .", + "entities": [] + }, + { + "id": "5437", + "type": "gene", + "text": "Mutation of KRKR to NGER retains MO15 in the cytoplasmic compartment , whilst the wild - type protein is detected exclusively in the nucleus .", + "entities": [ + "MO15" + ] + }, + { + "id": "5438", + "type": "gene", + "text": "The native enzyme purified from protease - B - deficient URA2 - transformed cells , was phosphorylated in vitro using catalytic subunits of pure cAMP - dependent protein kinase .", + "entities": [ + "protease - B", + "URA2", + "cAMP - dependent protein kinase" + ] + }, + { + "id": "5439", + "type": "gene", + "text": "INTERVENTIONS - - Patients allocated to treatment with levodopa / dopa decarboxylase inhibitor alone ( arm 1 ) , levodopa / decarboxylase inhibitor / selegiline in combination ( arm 2 ) , or bromocriptine ( arm 3 ) .", + "entities": [ + "levodopa / dopa decarboxylase", + "levodopa / decarboxylase" + ] + }, + { + "id": "5440", + "type": "gene", + "text": "The binding site for OxyR overlapped P1oxyR , reminiscent of the autoregulatory loops controlling expression of oxyR in enteric bacteria and characteristic of the LysR superfamily in general .", + "entities": [ + "OxyR", + "P1oxyR", + "oxyR", + "LysR superfamily" + ] + }, + { + "id": "5441", + "type": "gene", + "text": "A reversed - phase high - performance liquid chromatographic ( HPLC ) method for the determination of cocaine metabolites produced in vitro by serum and liver esterases is described .", + "entities": [ + "serum and liver esterases" + ] + }, + { + "id": "5442", + "type": "gene", + "text": "On the basis of this anatomic concept , the brachioplasty procedure was modified to provide secure anchoring of the arm flap to the axillary fascia along with strong superficial fascial system repair of incisions , reducing the risk of widening or migration of scars and unnatural contours .", + "entities": [] + }, + { + "id": "5443", + "type": "gene", + "text": "Hydrocortisone caused lymphopenia and inhibited the blastogenic response of peripheral blood lymphocytes to phytohemagglutinin and concanavalin A mitogens .", + "entities": [ + "phytohemagglutinin", + "concanavalin A" + ] + }, + { + "id": "5444", + "type": "gene", + "text": "RESULTS : Prevalence of obesity ( BMI SDS > 2 . 0 ) was < 2 % at diagnosis , but increased to 16 % at 3y .", + "entities": [] + }, + { + "id": "5445", + "type": "gene", + "text": "In the study on PCI mRNA expression in the reproductive organs , we first cloned rat PCI cDNA and then evaluated the effect of androgen on the PCI mRNA expression .", + "entities": [ + "PCI mRNA", + "rat PCI cDNA", + "PCI mRNA" + ] + }, + { + "id": "5446", + "type": "gene", + "text": "Two independent transgenic lines were produced , and both showed expression of the Gus gene specifically in the endosperm during mid - development ( first detected 10 - 12 d after anthesis ) .", + "entities": [ + "Gus gene" + ] + }, + { + "id": "5447", + "type": "gene", + "text": "Cognate promoter elements implicated in glucocorticoid - and cAMP - mediated regulation as well as in liver - , myeloid - , and lymphocyte - specific expression are located within the 5 ' flanking sequence .", + "entities": [] + }, + { + "id": "5448", + "type": "gene", + "text": "Transcription start sites of the plastid ACCase genes were estimated from the longest cDNA clones obtained by 5 ' - RACE ( rapid amplification of cDNA ends ) .", + "entities": [ + "ACCase genes" + ] + }, + { + "id": "5449", + "type": "gene", + "text": "We report the preliminary biochemical characterization of the T antigens encoded by three SV40 mutants , 5030 , 5031 , and 5061 , each of which have altered residues within or near the ATP binding pocket .", + "entities": [ + "T antigens" + ] + }, + { + "id": "5450", + "type": "gene", + "text": "Multiparity had a protective effect with 0 . 66 less risk ( 95 % CI 0 . 44 - 0 . 99 ) .", + "entities": [] + }, + { + "id": "5451", + "type": "gene", + "text": "The predicted DNA - binding , zinc finger domain protein sequence was strictly conserved .", + "entities": [ + "zinc finger domain protein" + ] + }, + { + "id": "5452", + "type": "gene", + "text": "Genomic Southern blot analysis and chromosome mapping showed that GPRK6 hybridizes to two closely related genes located on chromosomes 5 and 13 and are , therefore , distinct from the GPRK located near the Huntington disease locus on chromosome 4 .", + "entities": [ + "GPRK6", + "GPRK", + "Huntington disease locus" + ] + }, + { + "id": "5453", + "type": "gene", + "text": "Atopic dermatitis is an \" itch which rashes and not a rash which itches \" and therefore , any patient treatment program should address the multiplicity of potential trigger factors that provoke this itching .", + "entities": [] + }, + { + "id": "5454", + "type": "gene", + "text": "Disruption mutations have been constructed in the SLK1 gene .", + "entities": [ + "SLK1 gene" + ] + }, + { + "id": "5455", + "type": "gene", + "text": "slk1 null mutants cannot grow at 37 degrees C , but many cells can grow at 30 , 24 , and 17 degrees C .", + "entities": [ + "slk1 null mutants" + ] + }, + { + "id": "5456", + "type": "gene", + "text": "Patients subsequently returned to the clinic every 3 days to have the wounds checked and dressings changed .", + "entities": [] + }, + { + "id": "5457", + "type": "gene", + "text": "Fundus changes in ( type II ) mesangiocapillary glomerulonephritis simulating drusen : a histopathological report .", + "entities": [] + }, + { + "id": "5458", + "type": "gene", + "text": "However , experiments with S1 mapping of in vivo transcripts , gene disruptions in the alpha region , and a single - copy transcriptional fusion vector all suggested that these possible promoters were largely inactive during logarithmic growth , that the major promoter for the alpha operon lay upstream from the region cloned , and that the genes in the IF1 to L17 interval were cotranscribed .", + "entities": [ + "S1", + "IF1", + "L17" + ] + }, + { + "id": "5459", + "type": "gene", + "text": "Consistent with this similarity , the cdc28 - P8 mutant accumulates unspliced precursors at the restrictive temperature .", + "entities": [ + "cdc28" + ] + }, + { + "id": "5460", + "type": "gene", + "text": "Prostacyclin formation , reflected by the excretion rate of its stable metabolite 6 - keto - prostaglandin F1 alpha , was measured by means of radioimmunoassay in 4 - hour urine specimens obtained during a smoking - free period and after participants had inhaled smoke from four high - nicotine cigarettes .", + "entities": [] + }, + { + "id": "5461", + "type": "gene", + "text": "Stable patients have mucous hypersecretion and little evidence of acute inflammation .", + "entities": [] + }, + { + "id": "5462", + "type": "gene", + "text": "Deletions were examined in the LYS2 gene , using a set of 31 - to 156 - bp inserts that included inserts with no apparent potential for secondary structure as well as two quasipalindromes .", + "entities": [ + "LYS2 gene" + ] + }, + { + "id": "5463", + "type": "gene", + "text": "This sequence also confers VDR and vitamin D responsiveness to a heterologous promoter .", + "entities": [ + "VDR" + ] + }, + { + "id": "5464", + "type": "gene", + "text": "Myocardial infarction in patients with previous bypass surgery .", + "entities": [] + }, + { + "id": "5465", + "type": "gene", + "text": "However , the serum TNF - a concentration decreased significantly in patients receiving pentoxifylline ( basal 623 + / - 366 pg / ml ; 6th month 562 + / - 358 pg / ml , p < 0 . 01 ) , but not in the control group .", + "entities": [ + "serum TNF - a" + ] + }, + { + "id": "5466", + "type": "gene", + "text": "Conservation of function of Drosophila melanogaster abl and murine v - abl proteins in transformation of mammalian cells .", + "entities": [ + "Drosophila melanogaster abl", + "murine v - abl proteins" + ] + }, + { + "id": "5467", + "type": "gene", + "text": "Hepatitis B vaccination strategy for health - care workers in a country of intermediate hepatitis B endemicity .", + "entities": [] + }, + { + "id": "5468", + "type": "gene", + "text": "Analysis of Bcl - 2 / Bcl - 2 homodimerization using both in vitro binding assays as well as a yeast two - hybrid method provided evidence in support of a head - to - tail model for Bcl - 2 / Bcl - 2 homodimerization and revealed that sequences within the NH2 - terminal A domain interact with a structure that requires the presence of both the carboxyl B and C domains in combination .", + "entities": [ + "Bcl - 2", + "Bcl - 2", + "Bcl - 2", + "Bcl - 2" + ] + }, + { + "id": "5469", + "type": "gene", + "text": "The 5 ' untranslated and coding regions are contained within 12 exons , with the translation start site located within the first exon .", + "entities": [] + }, + { + "id": "5470", + "type": "gene", + "text": "Ninety - four percent of the EPs were tubal , and 90 % of the tubes exhibited some pathologic changes , including chronic salpingitis ( 49 . 5 % ) and follicular salpingitis ( 10 % ) , among others .", + "entities": [] + }, + { + "id": "5471", + "type": "gene", + "text": "An ion chromatographic method was used to determine Br ion in the urine of Greyhounds .", + "entities": [] + }, + { + "id": "5472", + "type": "gene", + "text": "Polyhomeotic and Posterior Sex Combs may participate in a more general transcriptional mechanism that causes modulated gene repression , whereas the inclusion of Polycomb protein in the complex at PREs leads to stable silencing .", + "entities": [ + "Polyhomeotic and Posterior Sex Combs", + "Polycomb protein", + "PREs" + ] + }, + { + "id": "5473", + "type": "gene", + "text": "This mutation no longer repressed the HPV - 11 upstream regulatory region - controlled reporter expression .", + "entities": [] + }, + { + "id": "5474", + "type": "gene", + "text": "PATIENTS OR OTHER PARTICIPANTS : Twenty children met the criteria for being learning disabled .", + "entities": [] + }, + { + "id": "5475", + "type": "gene", + "text": "A simple analytical method for l - menthol by high - performance liquid chromatography with a polarized photometric detector was established .", + "entities": [] + }, + { + "id": "5476", + "type": "gene", + "text": "Five healthy male subjects inspired air for 20 min and then 5 % CO2 / 95 % O2 for 30 min , of which the first 10 min was used to achieve a steady - state end - tidal CO2 measurement .", + "entities": [] + }, + { + "id": "5477", + "type": "gene", + "text": "Scratching during sleep in children with atopic dermatitis is associated with increased VO2 .", + "entities": [] + }, + { + "id": "5478", + "type": "gene", + "text": "Effect of chronic undernutrition on susceptibility to cold stress in young adult and aged rats .", + "entities": [] + }, + { + "id": "5479", + "type": "gene", + "text": "However , if EMPD involves the glans penis or perianal area , a search for internal malignancy is still warranted .", + "entities": [] + }, + { + "id": "5480", + "type": "gene", + "text": "The deduced amino acid sequence of CBP90 had no significant similarity to any other protein , but it had a proline - rich domain at the C - terminal region .", + "entities": [ + "CBP90" + ] + }, + { + "id": "5481", + "type": "gene", + "text": "Penicillin acylase ( PA ) from Escherichia coli ATCC11105 is a periplasmic heterodimer consisting of a 24 kDa small subunit and a 65 kDa large subunit .", + "entities": [ + "Penicillin acylase", + "PA" + ] + }, + { + "id": "5482", + "type": "gene", + "text": "To determine the genomic complexity of the deleted region shared among tumors , we assembled a physical map of the I Mbp SRO consisting predominantly of bacteriophage P1 - derived artificial chromosome ( PAC ) clones .", + "entities": [] + }, + { + "id": "5483", + "type": "gene", + "text": "The electrically induced motile responses were not suppressed in the presence of dinitrophenol or cytochalasin B .", + "entities": [] + }, + { + "id": "5484", + "type": "gene", + "text": "We previously showed that v - Rel , the oncoprotein of the avian retrovirus Rev - T , can increase expression from promoters containing binding sites for the cellular transcription factor Sp1 in chicken embryo fibroblasts ( S .", + "entities": [ + "v - Rel", + "Sp1" + ] + }, + { + "id": "5485", + "type": "gene", + "text": "The upstream promoter is located within the coding sequence of a divergent gene expressing a protein of Mr 39 kDa of unknown function .", + "entities": [] + }, + { + "id": "5486", + "type": "gene", + "text": "Using an image - processing computer , regional LV time - density curves were constructed for one cardiac cycle .", + "entities": [] + }, + { + "id": "5487", + "type": "gene", + "text": "RESULTS : Within 7 days , all groups re - acquired responding for heroin under CRF at rates similar to their pre - lesion performance .", + "entities": [] + }, + { + "id": "5488", + "type": "gene", + "text": "Demonstration of the agent was performed from the 6th to the 11th day p . i . by direct microscopic methods ( Stamp and auramine staining , fluorescent antibody technique ) ; the Coxiella content was determined by titration in embryonated hen ' s eggs .", + "entities": [] + }, + { + "id": "5489", + "type": "gene", + "text": "The concentration of alpha 2 - macroglobulin , alpha 1 - antitrypsin , plasminogen , C3 - complement , fibrinogen degradation products ( FDP ) and fibrinolytic activity , were studied in the aqueous humour and serum from nine patients with Fuchs ' endothelial dystrophy , 17 patients with uncomplicated senile cataract and in the secondary aqueous from six cataract patients .", + "entities": [ + "alpha 2 - macroglobulin", + "alpha 1 - antitrypsin", + "plasminogen", + "C3 - complement", + "fibrinogen degradation products", + "FDP" + ] + }, + { + "id": "5490", + "type": "gene", + "text": "Nutritional status in adults on an alternative or traditional diet ] BACKGROUND : Plant food lacks vitamin B12 , vitamin D and higher n - 3 polyunsaturated fatty acids .", + "entities": [] + }, + { + "id": "5491", + "type": "gene", + "text": "In this study , we purified and characterized the recombinant furin from the conditioned medium of these cells .", + "entities": [ + "recombinant furin" + ] + }, + { + "id": "5492", + "type": "gene", + "text": "After age 30 , mean hemoglobin levels for men gradually declined , while those in women rose , so that the sex difference diminished after 60 years of age .", + "entities": [ + "hemoglobin" + ] + }, + { + "id": "5493", + "type": "gene", + "text": "The prognosis of seven patients who received ABSCT was significantly better than that of 13 patients who received conventional therapy alone .", + "entities": [] + }, + { + "id": "5494", + "type": "gene", + "text": "While interactions of WT and variant TGF - alpha with the ErbBs all result in ErbB2 activation , they produce different biological consequences , suggesting that the various TGF - alpha precursors differentially modulate ErbB signaling .", + "entities": [ + "TGF - alpha", + "ErbBs", + "ErbB2", + "TGF - alpha precursors", + "ErbB" + ] + }, + { + "id": "5495", + "type": "gene", + "text": "The DSF regimen appears to have significant activity in patients who have metastatic pancreatic islet - cell carcinoma , and patient tolerance of the regimen is excellent , thus warranting further investigation .", + "entities": [] + }, + { + "id": "5496", + "type": "gene", + "text": "Cross - linking FcalphaR on wt - ITAM or IIA - ITAM cells triggered equivalent PI 3 - kinase - dependent activation of PKBalpha .", + "entities": [ + "FcalphaR", + "wt - ITAM", + "IIA - ITAM", + "PI 3 - kinase", + "PKBalpha" + ] + }, + { + "id": "5497", + "type": "gene", + "text": "Increased plasma IgE was also confirmed in the NC mice , and treatment with FK506 ointment reduced the plasma IgE level .", + "entities": [ + "IgE", + "IgE" + ] + }, + { + "id": "5498", + "type": "gene", + "text": "For this purpose , a segment of dxr was amplified from Synechococcus leopoliensis SAUG 1402 - 1 DNA via PCR using oligonucleotides for conserved regions .", + "entities": [ + "dxr" + ] + }, + { + "id": "5499", + "type": "gene", + "text": "The Fyn NH2 terminus was necessary but not sufficient for interaction with zeta and both Fyn kinase and SH2 domains were required , directing phosphorylation of zeta ITAM tyrosines and binding to zeta ITAM phosphotyrosines .", + "entities": [ + "Fyn NH2 terminus", + "Fyn kinase", + "SH2 domains", + "zeta ITAM", + "zeta ITAM" + ] + }, + { + "id": "5500", + "type": "gene", + "text": "Production costs included feed , non - feed operating , fixed , and replacement stock costs .", + "entities": [] + }, + { + "id": "5501", + "type": "gene", + "text": "Electrochemical detection of depressed circulating levels of vitamin K1 in osteoporosis .", + "entities": [] + }, + { + "id": "5502", + "type": "gene", + "text": "We conclude that the QLMI questionnaire has good potential as an instrument for assessing QL in post - AMI patients and that it can be successfully self - administered .", + "entities": [] + }, + { + "id": "5503", + "type": "gene", + "text": "HIV - 1 and hepatitis B virus infections in adolescents lodged in security institutes of Buenos Aires .", + "entities": [] + }, + { + "id": "5504", + "type": "gene", + "text": "We have investigated the role of cellular p21ras protein in insulin and insulin - like growth factor - I ( IGF - I ) signaling pathways .", + "entities": [ + "cellular p21ras protein", + "insulin", + "insulin - like growth factor - I", + "IGF - I" + ] + }, + { + "id": "5505", + "type": "gene", + "text": "With exon trapping , we could isolate five potential exons from the YAC 946E12 that spans the region , four of which could be placed in the contig in the vicinity of the breakpoints .", + "entities": [] + }, + { + "id": "5506", + "type": "gene", + "text": "Eliminating any subset of ASCUS reduces the ASCUS / SIL ratio but also significantly diminishes the sensitivity of the Papanicolaou test .", + "entities": [] + }, + { + "id": "5507", + "type": "gene", + "text": "The detectability of the defects in RCA or LAD region was 80 % in single - position scans in stress studies .", + "entities": [] + }, + { + "id": "5508", + "type": "gene", + "text": "Structural organization and expression of the mouse estrogen receptor .", + "entities": [ + "mouse estrogen receptor" + ] + }, + { + "id": "5509", + "type": "gene", + "text": "These results suggested a critical role for tyrosine residue 1229 in the regulation of L1 endocytosis .", + "entities": [ + "L1" + ] + }, + { + "id": "5510", + "type": "gene", + "text": "We suggest that MotA and AsiA may function like certain eukaryotic TAFs ( TATA binding protein ( TBP ) associated factors ) whose binding to TBP results in transcription from new core promoter sequences .", + "entities": [ + "MotA", + "AsiA", + "eukaryotic TAFs", + "TATA binding protein ( TBP ) associated factors", + "TBP" + ] + }, + { + "id": "5511", + "type": "gene", + "text": "Nuclear factor kappa B ( NF - kappaB ) is an important transcription factor for the genes of many pro - inflammatory proteins and is strongly activated by the cytokines interleukin - 1 and tumor necrosis factor ( TNF ) alpha under various pathological conditions .", + "entities": [ + "Nuclear factor kappa B", + "NF - kappaB", + "interleukin - 1", + "tumor necrosis factor ( TNF ) alpha" + ] + }, + { + "id": "5512", + "type": "gene", + "text": "A decanucleotide promoter sequence homologous to those found in humans and mice was located in the 5 ' untranslated region of one horse gene .", + "entities": [] + }, + { + "id": "5513", + "type": "gene", + "text": "In this paper , characterization is given of clinical and biochemical features of VH B course against the background of narcomania .", + "entities": [] + }, + { + "id": "5514", + "type": "gene", + "text": "To study retinoid signalling in zebrafish embryos , we developed a novel method to detect endogenous retinoids in situ in embryos , using a fusion protein of the ligand inducible transactivation domain of a retinoic acid receptor and a heterologous DNA binding domain .", + "entities": [ + "retinoic acid receptor" + ] + }, + { + "id": "5515", + "type": "gene", + "text": "The sign of Leser - Trelat : does it exist ?", + "entities": [] + }, + { + "id": "5516", + "type": "gene", + "text": "The sign of Leser - Trelat is usually regarded as a reliable cutaneous marker of internal malignancy .", + "entities": [] + }, + { + "id": "5517", + "type": "gene", + "text": "The 5 ' flanking sequence of the 3B gene is extremely A + T rich but contains five G / C rich stretches , each approximately 7bp long , which have strong sequence similarity to the G boxes found upstream of other developmentally regulated Dictyostelium genes .", + "entities": [ + "3B gene" + ] + }, + { + "id": "5518", + "type": "gene", + "text": "Removal of the carboxyl region severely reduced transcriptional activation .", + "entities": [] + }, + { + "id": "5519", + "type": "gene", + "text": "Unlike most other small G proteins which are expressed ubiquitously , TTF was transcribed only in hemopoietic cells as a 2 . 2 kb transcript .", + "entities": [ + "small G proteins", + "TTF" + ] + }, + { + "id": "5520", + "type": "gene", + "text": "Taken together , these results are consistent with the possibility that p202 protein contributes to the cell growth retardation activity of the IFNs , at least in part , by modulating p21 protein levels .", + "entities": [ + "p202 protein", + "IFNs", + "p21 protein" + ] + }, + { + "id": "5521", + "type": "gene", + "text": "Alternative splicing of CDC25B may therefore contribute to the control of cell proliferation .", + "entities": [ + "CDC25B" + ] + }, + { + "id": "5522", + "type": "gene", + "text": "Various transcripts are generated from the VCSA1 gene by alternative splicing and poly ( A ) processing in the rat submandibular gland .", + "entities": [ + "VCSA1 gene" + ] + }, + { + "id": "5523", + "type": "gene", + "text": "Differential activation of the extracellular signal - regulated kinase , Jun kinase and Janus kinase - Stat pathways by oncostatin M and basic fibroblast growth factor in AIDS - derived Kaposi ' s sarcoma cells .", + "entities": [ + "extracellular signal - regulated kinase", + "Jun kinase", + "Janus kinase", + "Stat", + "oncostatin M", + "basic fibroblast growth factor" + ] + }, + { + "id": "5524", + "type": "gene", + "text": "The complement C3a anaphylatoxin receptor ( C3aR ) is a seven - transmembrane G - protein coupled chemoattractant receptor that on binding the C3a peptide ligand mediates numerous cellular responses , including histamine release from mast cells . smooth muscle contraction , and the directed migration of eosinophils .", + "entities": [ + "complement C3a anaphylatoxin receptor", + "C3aR", + "seven - transmembrane G - protein coupled chemoattractant receptor", + "C3a peptide ligand" + ] + }, + { + "id": "5525", + "type": "gene", + "text": "IL - 1 and TNF increase AND - 34 transcript levels in thymic cortical reticular , thymic nurse , and fibroblast cell lines .", + "entities": [ + "IL - 1", + "TNF", + "AND - 34 transcript" + ] + }, + { + "id": "5526", + "type": "gene", + "text": "At baseline , serum levels of lycopene and FLOP were abnormally high and serum FLOP was correlated significantly with plasma cyclosporine levels ( r = 0 . 646 , p = 0 . 016 ) .", + "entities": [] + }, + { + "id": "5527", + "type": "gene", + "text": "The effects of tap ( TW ) or carbonated ( CW ) water on arterial pH , partial pressure of carbon dioxide ( PCO2 ) and plasma lactate were determined in heat - stressed broilers .", + "entities": [] + }, + { + "id": "5528", + "type": "gene", + "text": "Shear bond strength of a composite resin to an etched glass ionomer .", + "entities": [] + }, + { + "id": "5529", + "type": "gene", + "text": "The present study investigates whether prostaglandins \" cytoprotect \" the gastric mucosa against hemorrhage - induced stress ulceration by assessing the influence of 16 , 16 - dimethyl prostaglandin E2 ( 16 , 16 - dm PGE2 ) on gross and microscopic lesion formation , intramucosal tissue pH , H + back - diffusion , and mucosal blood flow in rat gastric mucosa exposed to luminal acid ( 100 mM HCl ) during hemorrhagic shock ( 13 ml / kg for 20 min ) .", + "entities": [] + }, + { + "id": "5530", + "type": "gene", + "text": "After cells were stably transfected with CIITA , endogenous MHC class II genes were constitutively expressed , and MHC class II promoters , delivered by transfection , were actively transcribed in CIITA - expressing cells .", + "entities": [ + "CIITA", + "MHC class II genes", + "MHC class II promoters", + "CIITA" + ] + }, + { + "id": "5531", + "type": "gene", + "text": "The reduced efficiency in the glycosylase activity is also reflected in a reduced ability of S120K MutY to prevent DNA mutations in vivo .", + "entities": [ + "glycosylase", + "S120K MutY" + ] + }, + { + "id": "5532", + "type": "gene", + "text": "Intra - articular dislocation of the patella .", + "entities": [] + }, + { + "id": "5533", + "type": "gene", + "text": "However , bilateral diffuse pulmonary infiltrations developed 21 days later .", + "entities": [] + }, + { + "id": "5534", + "type": "gene", + "text": "The present data also suggest that when compared to the systemic vascular bed , the pulmonary vascular bed is less responsive to bolus administration of ET - 1 .", + "entities": [ + "ET - 1" + ] + }, + { + "id": "5535", + "type": "gene", + "text": "Both functional analyses in undifferentiated and differentiated F9 cells and characterization of DNA - protein complexes in vitro have identified the sequence motifs GTGACT ( C ) , ATTGT , and GATA as the key transcription factor binding sites .", + "entities": [] + }, + { + "id": "5536", + "type": "gene", + "text": "Recombinant plasmids containing the entire 322 nt 5 ' UTR of exon 1 and a 1630 nt segment of 5 ' flanking sequence stimulated luciferase activity nearly 70 times higher than a promoterless control plasmid .", + "entities": [ + "luciferase" + ] + }, + { + "id": "5537", + "type": "gene", + "text": "A global response rate was 17 % ( 95 % confidence interval ( 95 % CI ) : 2 % - 32 % ) and the median overall survival was 12 months .", + "entities": [] + }, + { + "id": "5538", + "type": "gene", + "text": "Mutagenesis of the pecT regulatory region revealed the presence of two sites in which insertions reproduced the pec - 1 phenotype .", + "entities": [ + "pecT", + "pec - 1" + ] + }, + { + "id": "5539", + "type": "gene", + "text": "In control patients , baseline images presented Type I in 25 , Type II in 7 , and the Type III & IV in 0 , and the Type after loading was the same as the Type at baseline .", + "entities": [] + }, + { + "id": "5540", + "type": "gene", + "text": "The lytic cycle of KSHV , probably under the initial control of the KSHV / Rta gene , may directly contribute to tumor pathogenesis .", + "entities": [ + "KSHV / Rta gene" + ] + }, + { + "id": "5541", + "type": "gene", + "text": "The multidomain structure includes a cysteine - rich motif resembling those of protein kinase C and n - chimaerin and a putative pleckstrin homology domain .", + "entities": [ + "protein kinase C", + "n - chimaerin", + "pleckstrin homology domain" + ] + }, + { + "id": "5542", + "type": "gene", + "text": "In addition to the nine and 51 terminal amino acid forms already known , we identified a third with 43 terminal amino acids predicted to encode a novel RET protein isoform .", + "entities": [ + "RET protein isoform" + ] + }, + { + "id": "5543", + "type": "gene", + "text": "Telomeres prevent end - to - end fusions and exonucleolytic degradation , enable the end of the linear DNA molecule to replicate , and function in cell division .", + "entities": [] + }, + { + "id": "5544", + "type": "gene", + "text": "The purified recombinant protein was assayed for its enzyme activity by monitoring transfer of [ 3H ] methyl groups from the substrate DNA to the MGMT protein ; the activity was found to be stable at 90 degrees C for at least 30 min .", + "entities": [ + "MGMT protein" + ] + }, + { + "id": "5545", + "type": "gene", + "text": "A group of 66 DSM - IV paranoid schizophrenic in - patients were assessed three times using the SAPS , SANS , BPRS and PAS .", + "entities": [] + }, + { + "id": "5546", + "type": "gene", + "text": "However , in contrast with previous in vitro cell - free integration studies , alteration of the highly conserved CA dinucleotide resulted in a mutant which still retained 40 % of wild - type integration activity .", + "entities": [] + }, + { + "id": "5547", + "type": "gene", + "text": "DDP1 also localizes to heterochromatin in interphase nuclei of larval neuroblasts .", + "entities": [ + "DDP1" + ] + }, + { + "id": "5548", + "type": "gene", + "text": "Moreover , the reconstitution of eUSF and TFIID - depleted transcription complexes with purified protein fractions demonstrate that not only TFIID but also eUSF essentially participates in complex formation even on H5 promoter mutations lacking the TATA - box .", + "entities": [ + "eUSF", + "TFIID", + "TFIID", + "eUSF", + "H5 promoter" + ] + }, + { + "id": "5549", + "type": "gene", + "text": "These exons , further identified as exons 9 , 10 , and 11 , together encode the 37 amino acid residues present in alpha s1 - casein variant A but missing in variant F .", + "entities": [ + "alpha s1 - casein variant A" + ] + }, + { + "id": "5550", + "type": "gene", + "text": "We specially devised 3 types of turbo pumps , a centrifugal pump ( CFP ) , a mixed flow pump ( MFP ) , and an axial flow pump ( AFP ) , and analyzed their in vitro performance .", + "entities": [] + }, + { + "id": "5551", + "type": "gene", + "text": "With a BMI cutoff of 27 , mean cardiac NE spillover was 46 % lower in the obese subjects when compared with the lean subjects ( P = . 017 ) .", + "entities": [] + }, + { + "id": "5552", + "type": "gene", + "text": "Of the single - stranded DNA transformants , 65 % resulted from replacement of the resident met2 mutation by the exogenous wild - type allele .", + "entities": [ + "met2 mutation" + ] + }, + { + "id": "5553", + "type": "gene", + "text": "In TNF - resistant T24 bladder carcinoma cells , TNF failed to alter EGF - R tyrosine protein kinase activity although both EGF and phorbol ester were shown to modulate the enzymatic activity of the receptor in these cells .", + "entities": [ + "TNF", + "TNF", + "tyrosine protein kinase", + "EGF" + ] + }, + { + "id": "5554", + "type": "gene", + "text": "Genotoxic activity of a tobacco - specific nitrosamine .", + "entities": [] + }, + { + "id": "5555", + "type": "gene", + "text": "A multicentre study involving 9 Italian institutions was carried out to compare the efficacy and safety of ranitidine 150 mg b . i . d . and ranitidine 300 mg nocte in the treatment of reflux oesophagitis .", + "entities": [] + }, + { + "id": "5556", + "type": "gene", + "text": "Both proprioceptive and electroreceptive units showed a progression of receptive fields from anterior to posterior body in the rostral to caudal direction along the length of DGR .", + "entities": [] + }, + { + "id": "5557", + "type": "gene", + "text": "Ultrastructural and morphometric study of the myeloid parenchyma cells of mice prior and after X - ray exposure", + "entities": [] + }, + { + "id": "5558", + "type": "gene", + "text": "In nondiabetics the response of tcPO2 but not of LDF was influenced by the values at rest .", + "entities": [] + }, + { + "id": "5559", + "type": "gene", + "text": "Regulators of G protein signaling ( RGS ) proteins that contain DEP ( disheveled , EGL - 10 , pleckstrin ) and GGL ( G protein gamma subunit - like ) domains form a subfamily that includes the mammalian RGS proteins RGS6 , RGS7 , RGS9 , and RGS11 .", + "entities": [ + "G protein signaling ( RGS ) proteins", + "DEP", + "disheveled", + "EGL - 10", + "pleckstrin", + "GGL", + "G protein gamma subunit - like", + "RGS6", + "RGS7", + "RGS9", + "RGS11" + ] + }, + { + "id": "5560", + "type": "gene", + "text": "The 27 - base element interacts with a PDGF - activated serine / threonine phosphoprotein that is detected only within the nucleus of PDGF - treated 3T3 cells .", + "entities": [ + "PDGF" + ] + }, + { + "id": "5561", + "type": "gene", + "text": "The amplitudes of DPOAE also recovered to a greater extent and outer hair cell losses were less severe in the R - PIA - treated ears .", + "entities": [] + }, + { + "id": "5562", + "type": "gene", + "text": "In contrast , Y239 / 240F Shc , but not Y317F Shc , reduced the EGF - induced c - myc message .", + "entities": [ + "Y239 / 240F Shc", + "Y317F Shc", + "EGF", + "c - myc" + ] + }, + { + "id": "5563", + "type": "gene", + "text": "The most striking difference in the birch NAD ( P ) H - NR sequence in comparison to NADH - NR sequences was found at the putative pyridine nucleotide binding site .", + "entities": [ + "birch NAD ( P ) H - NR sequence", + "NADH - NR sequences" + ] + }, + { + "id": "5564", + "type": "gene", + "text": "We show here that the binding of C1F in vitro is sensitive to the concentration of calcium ions .", + "entities": [ + "C1F" + ] + }, + { + "id": "5565", + "type": "gene", + "text": "Moreover , LD50 in mice of RP - 170 ( 4 . 3 g / kg on i . v . ) was increased to 5 . 2 g / kg by oral administration .", + "entities": [] + }, + { + "id": "5566", + "type": "gene", + "text": "Whereas creatine kinase activity declined exponentially from a single peak , myoglobin appeared in multiple episodes inadequately represented by a single peak value and having no clear clinical correlation .", + "entities": [ + "creatine kinase", + "myoglobin" + ] + }, + { + "id": "5567", + "type": "gene", + "text": "Recognition mechanisms of the minus - strand origin of phage f1 by Escherichia coli RNA polymerase .", + "entities": [ + "Escherichia coli RNA polymerase" + ] + }, + { + "id": "5568", + "type": "gene", + "text": "Cranio - caudal differences in granulation tissue formation : an experimental study in the rat .", + "entities": [] + }, + { + "id": "5569", + "type": "gene", + "text": "Methoxyflurane and renal function", + "entities": [] + }, + { + "id": "5570", + "type": "gene", + "text": "Furthermore , the PH and PTB domains are highly homologous ( at least 40 % identical ) to those found in insulin receptor substrates 1 , 2 , and 3 ( IRS - 1 , IRS - 2 , and IRS - 3 ) .", + "entities": [ + "PH", + "insulin receptor substrates 1 , 2 , and 3", + "IRS - 1", + "IRS - 2", + "IRS - 3" + ] + }, + { + "id": "5571", + "type": "gene", + "text": "In DNase I footprinting protection analysis , both SFRE and ERE regions were protected by glutathione S - transferase - ERRalpha1 fusion protein .", + "entities": [ + "DNase I", + "SFRE", + "glutathione S - transferase", + "ERRalpha1" + ] + }, + { + "id": "5572", + "type": "gene", + "text": "W .", + "entities": [] + }, + { + "id": "5573", + "type": "gene", + "text": "In this study , to characterize the gene for protein Z , its organization and structure were determined by a combination of PCR amplification of leukocyte DNA and isolation of phage clones from a human genomic library .", + "entities": [ + "protein Z" + ] + }, + { + "id": "5574", + "type": "gene", + "text": "The patient was homozygous for the underlying mutation , which was found to be a G - - > T transversion within the acceptor splice site between intron e and exon 6 , abolishing normal RNA splicing .", + "entities": [] + }, + { + "id": "5575", + "type": "gene", + "text": "An in vivo ZAP - 70 substrate , SLP - 76 , implicated in Erk activation , also became rapidly tyrosine - phosphorylated in Jurkat cells , but not in P116 cells , upon treatment with H2O2 .", + "entities": [ + "ZAP - 70", + "SLP - 76", + "Erk" + ] + }, + { + "id": "5576", + "type": "gene", + "text": "By treating monkey COS cells with oligonucleotides linked to psoralen , we have generated targeted mutations in a simian virus 40 ( SV40 ) vector contained within the cells via intracellular triple helix formation .", + "entities": [] + }, + { + "id": "5577", + "type": "gene", + "text": "T antigen contains four H - 2Db - restricted cytotoxic T lymphocyte ( CTL ) recognition epitopes that are targets for CTL clones Y - 1 , Y - 2 , Y - 3 , and Y - 5 .", + "entities": [ + "T antigen" + ] + }, + { + "id": "5578", + "type": "gene", + "text": "No definite conclusions are possible because of the small number of patients involved in this phase II trial .", + "entities": [] + }, + { + "id": "5579", + "type": "gene", + "text": "Positive and significant correlations were found between the weeks of pregnancy and Se levels in kidney ( r = 0 . 433 , P = 0 . 023 ) and heart ( r = 0 . 313 , P = 0 . 030 ) .", + "entities": [] + }, + { + "id": "5580", + "type": "gene", + "text": "Cotransfection analyses of the T / EBP promoter - reporter constructs with a T / EBP expression vector into human HepG2 cells , which do not express T / EBP , suggested that autoregulation may be involved in controlling both rat and human T / EBP gene expression .", + "entities": [ + "T / EBP promoter - reporter constructs", + "T / EBP", + "T / EBP", + "human T / EBP gene" + ] + }, + { + "id": "5581", + "type": "gene", + "text": "At maximum photosensitivity the inhibitory amino acids gamma - aminobutyric acid and taurine were lower , and those of asparagine ( metabolite of the excitatory amino acid aspartate ) were higher , than when the animals were not photosensitive .", + "entities": [] + }, + { + "id": "5582", + "type": "gene", + "text": "The pseudolymphoma syndrome is a reversible reactive condition consisting of fever , lymphadenopathy and generalized rash .", + "entities": [] + }, + { + "id": "5583", + "type": "gene", + "text": "Thus , Fis acts as an accessory transcriptional activator at the mar promoter .", + "entities": [ + "Fis", + "mar promoter" + ] + }, + { + "id": "5584", + "type": "gene", + "text": "Comparison of German language versions of the QWB - SA and SF - 36 evaluating outcomes for patients with prostate disease .", + "entities": [] + }, + { + "id": "5585", + "type": "gene", + "text": "Overexpression of POG1 inhibits alpha - factor - induced G1 arrest and transcriptional repression of the CLN1 and CLN2 genes .", + "entities": [ + "POG1", + "alpha - factor", + "CLN1", + "CLN2 genes" + ] + }, + { + "id": "5586", + "type": "gene", + "text": "MVR typing of rare - length alleles indicates that they are comprised of disorganized sequences , although they usually bear a resemblance to one of the common alleles at the 5 ' - most end .", + "entities": [] + }, + { + "id": "5587", + "type": "gene", + "text": "In contrast , both C - Lys and C - Thr retained high levels of kinase activity and were capable of responding to stimulation .", + "entities": [] + }, + { + "id": "5588", + "type": "gene", + "text": "Objective responses also occurred in studies that explored sequential use of exemestane after failure of aminoglutethimide ( 26 % with exemestane 200 mg / day ) or other nonsteroidal aromatase inhibitors ( 6 . 6 % with exemestane 25 mg / day ) .", + "entities": [ + "aromatase" + ] + }, + { + "id": "5589", + "type": "gene", + "text": "Cam kinase II induces in vivo phosphorylation of Smad2 and Smad4 and , to a lesser extent , Smad3 .", + "entities": [ + "Cam kinase II", + "Smad2", + "Smad4", + "Smad3" + ] + }, + { + "id": "5590", + "type": "gene", + "text": "Chimaeric VP16 - E2 molecules suggest that the epithelial specific transcriptional activation of the BPV - 4 LCR promoter is mediated by the E2 transactivation domain .", + "entities": [ + "VP16", + "E2", + "BPV - 4 LCR promoter", + "E2 transactivation domain" + ] + }, + { + "id": "5591", + "type": "gene", + "text": "About 20 kb upstream of LAMB2 we found a gene encoding a transcribed , non - processed LAMB2 - like pseudogene ( LAMB2L ) .", + "entities": [ + "LAMB2", + "LAMB2 - like pseudogene", + "LAMB2L" + ] + }, + { + "id": "5592", + "type": "gene", + "text": "Four putative positive cDNA clones were isolated , and the largest insert ( pASB - 1 ) was sequenced in both orientations .", + "entities": [ + "pASB - 1" + ] + }, + { + "id": "5593", + "type": "gene", + "text": "The effects of high intensity light emissions , produced by a novel pulsed power energization technique ( PPET ) , on the survival of bacterial populations of verocytotoxigenic Escherichia coli ( serotype 0157 : H7 ) and Listeria monocytogenes ( serotype 4b ) were investigated .", + "entities": [] + }, + { + "id": "5594", + "type": "gene", + "text": "The pWP - 19 also encodes the AAV inverted terminal repeats for integration and replication and the herpes virus thymidine kinase promoter - driven gene for neomycin resistance ( neoR ) .", + "entities": [ + "pWP - 19", + "thymidine kinase", + "neoR" + ] + }, + { + "id": "5595", + "type": "gene", + "text": "CONCLUSION : In Cdks functioning throughout the cell cycle , tyrosine phosphorylation is inhibitory to the activation of kinase , whereas the phosphorylation of threonine in the T - loop is essential for activation .", + "entities": [ + "Cdks" + ] + }, + { + "id": "5596", + "type": "gene", + "text": "Myogenic differentiation can be inhibited by the adenovirus E1a protein in the rat L6 muscle cell line .", + "entities": [ + "E1a protein" + ] + }, + { + "id": "5597", + "type": "gene", + "text": "Primer extension and cDNA cloning were used to isolate the complete 5 ' end of the Nramp1 mRNA .", + "entities": [ + "Nramp1 mRNA" + ] + }, + { + "id": "5598", + "type": "gene", + "text": "Peripheral visual stimuli and monoaural auditory stimuli were used as targets .", + "entities": [] + }, + { + "id": "5599", + "type": "gene", + "text": "When the entire diet consisted of SBF , voluntary feed intake was reduced , indicating that SBF should not be fed to ponies as the sole dietary ingredient .", + "entities": [] + }, + { + "id": "5600", + "type": "gene", + "text": "We conducted a prospective , randomized controlled trial of metoprolol , a selective beta - blocker for prevention of gastrointestinal bleeding from portal hypertension in 29 non - selected patients with liver disease and previous gastrointestinal bleeding .", + "entities": [] + }, + { + "id": "5601", + "type": "gene", + "text": "Differences in profiles of viscosity variables between subgroups of EAD in RA patients were observed .", + "entities": [] + }, + { + "id": "5602", + "type": "gene", + "text": "Cyclophilins are cis - trans - peptidyl - prolyl isomerases that bind to and are inhibited by the immunosuppressant cyclosporin A ( CsA ) .", + "entities": [ + "Cyclophilins", + "cis - trans - peptidyl - prolyl isomerases" + ] + }, + { + "id": "5603", + "type": "gene", + "text": "Three mog - 1 alleles possess premature stop codons and are likely to be null alleles , and one is a missense mutation and is likely to retain residual activity .", + "entities": [ + "mog - 1 alleles" + ] + }, + { + "id": "5604", + "type": "gene", + "text": "mog - 1 mRNA is expressed in both germ line and somatic tissues and appears to be ubiquitous .", + "entities": [ + "mog - 1 mRNA" + ] + }, + { + "id": "5605", + "type": "gene", + "text": "During surgery bone cysts were excised and filled by bone grafts .", + "entities": [] + }, + { + "id": "5606", + "type": "gene", + "text": "The effects produced by oral administration of 500 mg / kg p - xylene or toluene lasted at least 8 hr , while the effect of inhaled p - xylene dissipated within 75 min of removal from the exposure .", + "entities": [] + }, + { + "id": "5607", + "type": "gene", + "text": "DESIGN : Prospective cohort study with a 20 y follow - up period , the First National Health and Examination Survey ( NHANES 1 ) Epidemiologic Follow - up Study ( NHEFS ) .", + "entities": [] + }, + { + "id": "5608", + "type": "gene", + "text": "This approach enables the sources of error in the calculation of nutrient utilization to be readily identified , and their effect on precision to be assessed in different nutritional and metabolic states .", + "entities": [] + }, + { + "id": "5609", + "type": "gene", + "text": "We show that in contrast to SRC1 , direct binding of CBP to the estrogen receptor is weak , suggesting that SRC1 functions primarily as an adaptor to recruit CBP and p300 .", + "entities": [ + "SRC1", + "CBP", + "estrogen receptor", + "SRC1", + "CBP", + "p300" + ] + }, + { + "id": "5610", + "type": "gene", + "text": "However , conversions of 12 mm or more from a documented negative result indicated spread of infection .", + "entities": [] + }, + { + "id": "5611", + "type": "gene", + "text": "The protein mixtures of sesame flour and soybean flour were well accepted .", + "entities": [] + }, + { + "id": "5612", + "type": "gene", + "text": "PPAR gamma mRNA levels were reduced by 95 % with 3 nM TNF alpha treatment for 24 h .", + "entities": [ + "PPAR gamma mRNA", + "TNF alpha" + ] + }, + { + "id": "5613", + "type": "gene", + "text": "Induction of Fas ligand expression by HIV involves the interaction of Nef with the T cell receptor zeta chain .", + "entities": [ + "Fas ligand", + "Nef", + "T cell receptor zeta chain" + ] + }, + { + "id": "5614", + "type": "gene", + "text": "Sodium restriction in cardiac failure .", + "entities": [] + }, + { + "id": "5615", + "type": "gene", + "text": "Moreover , a high proportion of blood samples from a random sample of the rest of the suspects tested positive for trypanosome - specific DNA by PCR ( 79 . 9 % for T . b . gambiense and 13 . 9 % for T . b . rhodesiense ) .", + "entities": [] + }, + { + "id": "5616", + "type": "gene", + "text": "Although basal vessels may constrict distal parenchymal vessels tend to dilate after SAH .", + "entities": [] + }, + { + "id": "5617", + "type": "gene", + "text": "We have used a site - directed mutagenesis approach to examine how the Xaa and hydroxy ( Ser / Thr ) amino acid residues in sequons influence core - glycosylation efficiency .", + "entities": [] + }, + { + "id": "5618", + "type": "gene", + "text": "Physical principles in therapeutic apheresis .", + "entities": [] + }, + { + "id": "5619", + "type": "gene", + "text": "Several PTPases were expressed abundantly in the 5 - FU - treated bone marrow stem cells .", + "entities": [ + "PTPases" + ] + }, + { + "id": "5620", + "type": "gene", + "text": "Sequence analysis indicates that in addition to an ATA and GC box , this region contains domains that have been implicated in the regulation of other muscle - specific genes : a CArG box at - 91 bp ; myocyte - specific enhancer - binding nuclear factor 1 binding site homologies at - 58 , - 535 , and - 583 bp ; and a muscle - CAAT consensus sequence at - 394 bp relative to the cap site .", + "entities": [ + "myocyte - specific enhancer - binding nuclear factor 1 binding site" + ] + }, + { + "id": "5621", + "type": "gene", + "text": "We have also tested Src SH2 mutants for their binding properties and have interpreted our results in light of the recent crystal structure solution for the Src SH2 domain .", + "entities": [ + "SH2", + "SH2" + ] + }, + { + "id": "5622", + "type": "gene", + "text": "Furthermore , a pTyr317 Shc phosphopeptide selectively recognized Grb2 , Sos1 , SHIP , and the p85 subunit of phosphatidylinositol 3 ' kinase from mast cells , as characterized by mass spectrometry .", + "entities": [ + "pTyr317 Shc phosphopeptide", + "Grb2", + "Sos1", + "SHIP", + "p85 subunit", + "phosphatidylinositol 3 ' kinase" + ] + }, + { + "id": "5623", + "type": "gene", + "text": "All clinical isolates were concomitantly tested by disk diffusion and agar dilution procedures as outlined by the National Committee for Clinical Laboratory Standards .", + "entities": [] + }, + { + "id": "5624", + "type": "gene", + "text": "The hydropathy plot revealed a rather hydrophilic N - terminal region and the absence of a hydrophobic signal peptide .", + "entities": [] + }, + { + "id": "5625", + "type": "gene", + "text": "But no influence was observed at lower concentrations than 1 / 4 MIC of AMK .", + "entities": [] + }, + { + "id": "5626", + "type": "gene", + "text": "Low NA and A may participate in lowering the plasma renin activity which in PA in suppressed , sometimes disproportionately to the actual body sodium content .", + "entities": [ + "plasma renin" + ] + }, + { + "id": "5627", + "type": "gene", + "text": "COUP transcription factor is a member of the steroid receptor superfamily .", + "entities": [ + "COUP transcription factor", + "steroid receptor superfamily" + ] + }, + { + "id": "5628", + "type": "gene", + "text": "The c - Ets - 1 oncoprotein is a transcription activator that specifically binds to DNA .", + "entities": [ + "c - Ets - 1 oncoprotein" + ] + }, + { + "id": "5629", + "type": "gene", + "text": "We have isolated a novel protein from Drosophila nuclear extracts which binds specifically to a site in this second region .", + "entities": [] + }, + { + "id": "5630", + "type": "gene", + "text": "Supraventricular arrhythmias - - digoxin and quinidine revisited .", + "entities": [] + }, + { + "id": "5631", + "type": "gene", + "text": "These residues , Ile244 at the extracellular end of transmembrane helix 3 , and Tyr318 at the COOH - terminal portion of extracellular loop 2 , are replaced by Leu and Ile in the PTH - 1 receptor , respectively .", + "entities": [ + "PTH - 1 receptor" + ] + }, + { + "id": "5632", + "type": "gene", + "text": "Elevated maternal alpha fetoproteins and oligoamnios : fetal prognosis", + "entities": [ + "maternal alpha fetoproteins" + ] + }, + { + "id": "5633", + "type": "gene", + "text": "Hyperprolactinaemia , moderate hypogonadism , infraclinical neuropathies , arterial stenoses and moderate venous leakages seem to play a partial role of organic starter or cofactor , the sexual consequences of which are amplified by psychological factors , partly secondary to the initial sexual failures .", + "entities": [] + }, + { + "id": "5634", + "type": "gene", + "text": "We enrolled 253 HIV - antibody positive heroin addicts without HIV - related disease ( n = 81 ) or with persistent generalized lymphadenopathy ( n = 172 ) in a prospective study to evaluate clinical progression to AIDS related complex ( ARC ) or AIDS and to identify factors of possible prognostic relevance .", + "entities": [ + "HIV - antibody" + ] + }, + { + "id": "5635", + "type": "gene", + "text": "Estradiol is known to induce expression of certain proto - oncogenes , and this led us to examine potential regulatory regions of the cellular c - fos oncogene .", + "entities": [ + "cellular c - fos oncogene" + ] + }, + { + "id": "5636", + "type": "gene", + "text": "Although it is well known that calcium channel blockers can influence contraction of vascular smooth muscle , there is less knowledge on its effect on excitation contraction coupling in the endocrine glands and more specifically on insulin and glucagon release .", + "entities": [ + "insulin", + "glucagon" + ] + }, + { + "id": "5637", + "type": "gene", + "text": "The Tax / IKKgamma interaction serves to recruit Tax to the IKK catalytic subunits , IKKalpha and IKKbeta , and this recruitment appears to be an essential mechanism by which Tax stimulates the activity of IKK .", + "entities": [ + "Tax", + "IKKgamma", + "Tax", + "IKK catalytic subunits", + "IKKalpha", + "IKKbeta", + "Tax", + "IKK" + ] + }, + { + "id": "5638", + "type": "gene", + "text": "Transcription start site mapping identified the presence of an aphidicolin - sensitive late transcript arising from a TAAG motif located at - 352 nucleotides and an aphidicolin - insensitive early transcript originating from a TTGT motif located 35 nucleotides downstream to a TATA box at - 312 nucleotides , with respect to the + 1 ATG of lef2 .", + "entities": [ + "lef2" + ] + }, + { + "id": "5639", + "type": "gene", + "text": "With constructs containing the binding site of one gene fused to the promoter of the other , we demonstrated that the positional requirements are a function of the specific binding site , not the promoter .", + "entities": [] + }, + { + "id": "5640", + "type": "gene", + "text": "To evaluate the hepatic regenerative response in patients with alcoholic liver disease , sera from 263 patients with severe alcoholic hepatitis and / or cirrhosis were analyzed for hepatocyte growth factor ( HGF ) and alpha - fetoprotein ( AFP ) .", + "entities": [ + "hepatocyte growth factor", + "HGF", + "alpha - fetoprotein", + "AFP" + ] + }, + { + "id": "5641", + "type": "gene", + "text": "Data are presented hinting that the 15 beta - hydroxy - , metabolite of CPA may actually be the biologically active agent .", + "entities": [] + }, + { + "id": "5642", + "type": "gene", + "text": "Transformation blocks differentiation - induced inhibition of serum response factor interactions with serum response elements .", + "entities": [ + "serum response factor" + ] + }, + { + "id": "5643", + "type": "gene", + "text": "This study investigated whether boron would enhance the ability of 17beta - estradiol ( E2 ) or parathyroid hormone ( PTH ) to improve bone quality in ovariectomized OVX rats .", + "entities": [ + "parathyroid hormone", + "PTH" + ] + }, + { + "id": "5644", + "type": "gene", + "text": "The results of these studies demonstrate that the rat HDL receptor SR - BI promoter contains two sterol response elements ( pSRE and dSRE ) through which SREBP - 1a can bind and activate transcription of this gene .", + "entities": [ + "SR - BI", + "SREBP - 1a" + ] + }, + { + "id": "5645", + "type": "gene", + "text": "This motif , first described for the Drosophila homeobox activator DEAF - 1 , identifies an emerging group of metazoan transcriptional modulators .", + "entities": [ + "Drosophila homeobox activator DEAF - 1" + ] + }, + { + "id": "5646", + "type": "gene", + "text": "Control of transcription of the erbB - 2 gene is an important determinant of receptor expression .", + "entities": [ + "erbB - 2 gene" + ] + }, + { + "id": "5647", + "type": "gene", + "text": "Here , the PEX5 - TPR domains from human , tobacco , and nematode were inserted into a TPR - less yeast Pex5p construct to generate Pex5p chimaeras .", + "entities": [ + "PEX5", + "Pex5p", + "Pex5p" + ] + }, + { + "id": "5648", + "type": "gene", + "text": "The sample is deproteinized and after centrifugation valproic acid in the supernatant is measured in the free form by direct injection into the gas chromatograph .", + "entities": [] + }, + { + "id": "5649", + "type": "gene", + "text": "These findings suggest that the MAP kinase activator / MAP kinase system may be the downstream components of ras signal transduction pathways .", + "entities": [ + "MAP kinase activator", + "MAP kinase", + "ras" + ] + }, + { + "id": "5650", + "type": "gene", + "text": "Evaluating dietary department management .", + "entities": [] + }, + { + "id": "5651", + "type": "gene", + "text": "Ume6p , which also controls the expression of early meiotic genes , represses CAR1 expression through a sequence called URS , as a function of nitrogen availability .", + "entities": [ + "Ume6p", + "CAR1" + ] + }, + { + "id": "5652", + "type": "gene", + "text": "A phylogenetic analysis of the reverse transcriptase domain confirms our differential genetic assessment that Cyclops from pea is a novel element with no specific relationship to the previously described Gypsy - like elements from plants .", + "entities": [ + "reverse transcriptase domain", + "Cyclops", + "Gypsy - like elements" + ] + }, + { + "id": "5653", + "type": "gene", + "text": "J .", + "entities": [] + }, + { + "id": "5654", + "type": "gene", + "text": "Exchanging the human propeptide in this chimera with either the murine MIC - 1 or TGF - beta1 propeptide resulted in secretion of the unprocessed , monomeric chimera , suggesting a specific interaction between the human MIC - 1 propeptide and mature peptide .", + "entities": [ + "murine MIC - 1", + "TGF - beta1 propeptide", + "human MIC - 1 propeptide" + ] + }, + { + "id": "5655", + "type": "gene", + "text": "Four cases of synovial chondromatosis are presented .", + "entities": [] + }, + { + "id": "5656", + "type": "gene", + "text": "Titration of the human and porcine proteins with 2 - nitro - 5 - thiosulfabenzoate indicates that membrane dipeptidase additionally possesses two intrachain disulfide bonds .", + "entities": [ + "membrane dipeptidase" + ] + }, + { + "id": "5657", + "type": "gene", + "text": "This study evaluates the feasibility of indirect mesenteric lymphangiography as a colonoscopic technique in a canine model .", + "entities": [] + }, + { + "id": "5658", + "type": "gene", + "text": "Gel - mobility shift analysis was also performed for the CCAAT motif at - 67 .", + "entities": [] + }, + { + "id": "5659", + "type": "gene", + "text": "The isolated plasmin fragments of VEGF were compared with respect to heparin binding , interaction with soluble VEGF receptors , and ability to promote endothelial cell mitogenesis .", + "entities": [ + "plasmin", + "VEGF", + "VEGF receptors" + ] + }, + { + "id": "5660", + "type": "gene", + "text": "Structure - function analysis of the Z - DNA - binding domain Zalpha of dsRNA adenosine deaminase type I reveals similarity to the ( alpha + beta ) family of helix - turn - helix proteins .", + "entities": [ + "dsRNA adenosine deaminase type I", + "( alpha + beta ) family", + "helix - turn - helix proteins" + ] + }, + { + "id": "5661", + "type": "gene", + "text": "We isolated several overlapping A - phage and cosmid clones that cover more than 100 kb of human DNA and contained the entire VDR gene .", + "entities": [ + "VDR gene" + ] + }, + { + "id": "5662", + "type": "gene", + "text": "Upon UV damage , Crb2 is transiently modified , probably phosphorylated , with a similar timing of phosphorylation in Chk1 kinase , which is reported to restrain Cdc2 activation .", + "entities": [ + "Crb2", + "Chk1 kinase", + "Cdc2" + ] + }, + { + "id": "5663", + "type": "gene", + "text": "A high reactor pH ( + / - 8 ) , a short solid retention time ( < 150 days ) , and the presence of a substantial SRB population in the inoculum may considerably reduce the time required for acetate - utilising SRB to outcompete MB .", + "entities": [] + }, + { + "id": "5664", + "type": "gene", + "text": "The human gene fragment ligated to the minimal rat liver glucokinase promoter was shown to work as an enhancer in the hepatocyte transfection system .", + "entities": [ + "glucokinase" + ] + }, + { + "id": "5665", + "type": "gene", + "text": "In insulin - responsive cells , Akt phosphorylates and inactivates the serine / threonine kinase glycogen synthase kinase - 3 ( GSK - 3 ) .", + "entities": [ + "insulin", + "Akt", + "glycogen synthase kinase - 3", + "GSK - 3" + ] + }, + { + "id": "5666", + "type": "gene", + "text": "Copyright 2000 Academic Press .", + "entities": [] + }, + { + "id": "5667", + "type": "gene", + "text": "Students , parents , teachers and hearing disorders", + "entities": [] + }, + { + "id": "5668", + "type": "gene", + "text": "Both inserts are larger than their homologues in eIF - 2alpha kinases .", + "entities": [ + "eIF - 2alpha kinases" + ] + }, + { + "id": "5669", + "type": "gene", + "text": "Both resting blood flow ( RBF ) and maximal blood flow ( NBF ) were studied by Xenon 133 clearance .", + "entities": [] + }, + { + "id": "5670", + "type": "gene", + "text": "Induction of correctly spliced germline transcripts is necessary to target a switch region for recombination and switching .", + "entities": [] + }, + { + "id": "5671", + "type": "gene", + "text": "Dynamic decision making : human control of complex systems .", + "entities": [] + }, + { + "id": "5672", + "type": "gene", + "text": "In this respect C reactive protein concentrations are superior to white cell count , erythrocyte sedimentation rate , and temperature and the concentrations of antiproteases .", + "entities": [ + "C reactive protein" + ] + }, + { + "id": "5673", + "type": "gene", + "text": "Purified P7 could be assembled onto particles lacking P7 and particles lacking both P2 ( RNA polymerase ) and P7 .", + "entities": [ + "Purified P7", + "P7", + "P2", + "RNA polymerase", + "P7" + ] + }, + { + "id": "5674", + "type": "gene", + "text": "A new set of cDNA clones spanning approximately 3 . 2 kb was isolated from a lambda - ZAP goose liver cDNA library using the 5 ' - most exon - containing fragment of the 5 ' - most genomic DNA clone .", + "entities": [] + }, + { + "id": "5675", + "type": "gene", + "text": "An experiment was carried on 133 grown up fowls and broilers from 4 industrial farms , vaccinated with spray lento and mesogenic vaccines for straining the immunity against pseodopest through RIHA and provoking pseudoplague with a pathogenic virus .", + "entities": [] + }, + { + "id": "5676", + "type": "gene", + "text": "Correlating with the previous observation that CBF binding to the 78C1 site is enhanced by EGTA and EDTA , these divalent cation chelators specifically stimulate 78C1 - directed transcription .", + "entities": [ + "CBF" + ] + }, + { + "id": "5677", + "type": "gene", + "text": "Deglycosylation with endoglycosidase H showed that the mutant receptors had mainly high - mannose oligosaccharide chains .", + "entities": [ + "endoglycosidase H" + ] + }, + { + "id": "5678", + "type": "gene", + "text": "RNase protection assays reveal that this gene , unr , is transcribed in the same direction as N - ras and that its 3 ' end is located just 130 base pairs away from the point at which N - ras transcription begins .", + "entities": [ + "RNase", + "unr", + "N - ras", + "N - ras" + ] + }, + { + "id": "5679", + "type": "gene", + "text": "Although popular this hypothesis is far from explaining all the clinical facts , namely that rigidity is equal in extensor and flexor , proximal and distal muscles .", + "entities": [] + }, + { + "id": "5680", + "type": "gene", + "text": "Five of the patients with increased L - L size had a normal A - P diameter .", + "entities": [] + }, + { + "id": "5681", + "type": "gene", + "text": "Immunohistochemical analysis of several rat organs also showed staining in epithelial cells .", + "entities": [] + }, + { + "id": "5682", + "type": "gene", + "text": "Morphine - dependent and control rats in an oral free - choice protocol were treated with gamma - vinyl GABA ( GVG ) , 60 , 120 and 240 mg / kg IP , for 3 days over three successive periods .", + "entities": [] + }, + { + "id": "5683", + "type": "gene", + "text": "Patients with types I and III MPGN did not differ in age at apparent onset , age at diagnosis , or interval from apparent onset of symptoms to diagnosis ( biopsy ) .", + "entities": [] + }, + { + "id": "5684", + "type": "gene", + "text": "Twenty - five patients ( 80 , 6 % ) with mixed neoplasms were operated on by total conservative parotidectomy ( T . C . P . ) , 3 ( 9 , 7 % ) by S . P . and 3 ( 9 , 7 % ) by En .", + "entities": [] + }, + { + "id": "5685", + "type": "gene", + "text": "The importance of selective renal vein phlebography in the evaluation of unexplained hematuria and filing defects in the excretory urogram is illustrated .", + "entities": [] + }, + { + "id": "5686", + "type": "gene", + "text": "FN - stimulated c - Src PTK activity was enhanced by wild type FAK expression , whereas FN - stimulated activation of ERK2 was blocked by expression of the c - Src binding site Phe - 397 mutant of FAK .", + "entities": [ + "FN", + "PTK", + "FAK", + "FN", + "ERK2", + "c - Src binding site Phe - 397 mutant", + "FAK" + ] + }, + { + "id": "5687", + "type": "gene", + "text": "The therapy with a H2 - receptor antagonist is less effective than the triple therapies with omeprazole or lansoprazole .", + "entities": [ + "H2 - receptor" + ] + }, + { + "id": "5688", + "type": "gene", + "text": "These findings indicate the involvement of Sp1 and an Inr in non - cell - specific regulation and a Kruppel - like transcription factor and Sp1 in the cell - specific regulation of the LTC ( 4 ) S gene .", + "entities": [ + "Sp1", + "Kruppel - like transcription factor", + "Sp1", + "LTC ( 4 ) S gene" + ] + }, + { + "id": "5689", + "type": "gene", + "text": "Beta blocking agents .", + "entities": [] + }, + { + "id": "5690", + "type": "gene", + "text": "The patient was a 78 - year - old male in whom skin lesions preceded the diagnosis of myelofibrosis .", + "entities": [] + }, + { + "id": "5691", + "type": "gene", + "text": "The changes after treatment were observed chiefly by electromyography while sensory and motor improvement were also recorded as auxiliary indicators .", + "entities": [] + }, + { + "id": "5692", + "type": "gene", + "text": "Is radical trachelectomy a safe alternative to radical hysterectomy for patients with stage IA - B carcinoma of the cervix ?", + "entities": [] + }, + { + "id": "5693", + "type": "gene", + "text": "BACKGROUND : The prognosis associated with lymph node negative , early stage carcinoma of the cervix is excellent , with 5 - year survival rates greater than 90 % .", + "entities": [] + }, + { + "id": "5694", + "type": "gene", + "text": "To study the sensitivity of some central brain structures to the action of an electromagnetic field of decimeter waves ( EMF of DW ) a dynamic investigation of single unit activity was undertaken .", + "entities": [] + }, + { + "id": "5695", + "type": "gene", + "text": "Cell adhesion and migration assays demonstrate that alpha 6 beta 1 is the major laminin receptor in undifferentiated F9 cells as well as F9 - derived PE cells .", + "entities": [ + "alpha 6 beta 1", + "laminin receptor" + ] + }, + { + "id": "5696", + "type": "gene", + "text": "Using fluorescence in situ hybridization , we mapped the chromosome - 17 breakpoint in a patient with acampomelic CMPD and sex reversal , who carries a de novo constitutional t ( 12 ; 17 ) translocation , between two known cosmid markers in the 17q24 - q25 region .", + "entities": [] + }, + { + "id": "5697", + "type": "gene", + "text": "The median levels of particles with 50 % cut - off aerodynamic diameters of 10 ( PM10 ) and 2 . 5 microm ( PM2 . 5 ) were 170 ( range 103 - 613 ) and 95 ( range 61 - 218 ) micro x m - 3 , respectively .", + "entities": [] + }, + { + "id": "5698", + "type": "gene", + "text": "The more traditional SERMS , clomiphene citrate and tamoxifen , will be reviewed along with such modern drugs as raloxifene and faslodex , with emphasis upon their actions on breast , uterus , bone and lipids .", + "entities": [] + }, + { + "id": "5699", + "type": "gene", + "text": "Biliary - enteric fistulas", + "entities": [] + }, + { + "id": "5700", + "type": "gene", + "text": "The effect of feeding patterns on fat deposition in mice .", + "entities": [] + }, + { + "id": "5701", + "type": "gene", + "text": "Drug use in trauma victims .", + "entities": [] + }, + { + "id": "5702", + "type": "gene", + "text": "In vivo , CARbeta / RXRalpha activated transcription from an HD - PPRE luciferase reporter construct .", + "entities": [ + "CARbeta", + "RXRalpha", + "HD", + "luciferase reporter construct" + ] + }, + { + "id": "5703", + "type": "gene", + "text": "We have found that mcs4 - cells are defective at activation of Spc1 in response to various forms of stress .", + "entities": [ + "mcs4", + "Spc1" + ] + }, + { + "id": "5704", + "type": "gene", + "text": "Basic fibroblast growth factor ( bFGF ) has been shown to induce angiogenesis in various animal models , but the methods of administration used experimentally are not clinically feasible .", + "entities": [ + "Basic fibroblast growth factor", + "bFGF" + ] + }, + { + "id": "5705", + "type": "gene", + "text": "The number of crystalline deposits is less in the advanced atrophic areas of the RPE - choriocapillaris complex .", + "entities": [] + }, + { + "id": "5706", + "type": "gene", + "text": "Resting VE in the luteal phase was 7 . 8 % greater than that in the follicular phase .", + "entities": [] + }, + { + "id": "5707", + "type": "gene", + "text": "Chronic administration of sodium cyanate decreases O2 extraction ratio in dogs .", + "entities": [] + }, + { + "id": "5708", + "type": "gene", + "text": "Subsequently , we show that the reexpression of the r - PTPeta gene in highly malignant rat thyroid cells transformed by retroviruses carrying the v - mos and v - ras - Ki oncogenes suppresses their malignant phenotype .", + "entities": [ + "r - PTPeta gene", + "v - mos", + "v - ras - Ki oncogenes" + ] + }, + { + "id": "5709", + "type": "gene", + "text": "The efficacy of these immunosuppressive drugs is clinical proven .", + "entities": [] + }, + { + "id": "5710", + "type": "gene", + "text": "The aim of this study was to assess the reproducibility of a number of simplified clearance methods using chromium - 51 ethylenediamine tetraacetic acid ( 51Cr - EDTA ) and to compare these with the multiple blood sample technique .", + "entities": [] + }, + { + "id": "5711", + "type": "gene", + "text": "The relatively scanty number of examples , which could be justified by the variety and complexity of combined exposure , allows to conclude that life - style factors have considerable influence on interindividual differences in susceptibility to xenobiotics toxicity .", + "entities": [] + }, + { + "id": "5712", + "type": "gene", + "text": "Studies on the intracutaneous infection of rabbits by Staphylococcus aureus .", + "entities": [] + }, + { + "id": "5713", + "type": "gene", + "text": "Despite abundant expression of NtmybAS transcripts in mature pollen , gPAL1 transcripts were not detectable in pollen .", + "entities": [ + "NtmybAS transcripts", + "gPAL1 transcripts" + ] + }, + { + "id": "5714", + "type": "gene", + "text": "Brain scan with 99mTc - labelled macroaggregated albumin ( MAA brain scan ) and computed tomography studies ( CT ) were performed on 78 patients with intracranial diseases .", + "entities": [ + "macroaggregated albumin", + "MAA" + ] + }, + { + "id": "5715", + "type": "gene", + "text": "These protective influences were observed throughout the range of filling pressures measured , from 0 to 30 mmHg .", + "entities": [] + }, + { + "id": "5716", + "type": "gene", + "text": "To account for this observation , other possible causes include increased CSF pulsation in children creating motion artifact , changes in arterial oxygen concentration intrinsic to propofol or related to the supplemental oxygen normally administered , or changes in CSF protein levels related to propofol binding to proteins for uptake into CSF .", + "entities": [] + }, + { + "id": "5717", + "type": "gene", + "text": "ISS and the acute physiology and chronic health evaluation ( APACHE II ) calculated on admission .", + "entities": [] + }, + { + "id": "5718", + "type": "gene", + "text": "CONCLUSION : The probability of cardiopulmonary complications increases significantly when patients develop class 1 HELLP syndrome .", + "entities": [] + }, + { + "id": "5719", + "type": "gene", + "text": "The combination PIP 64 micrograms - PEF 4 micrograms prevents the frequent secondary regrowth seen after 6 hours with the antibiotics used alone .", + "entities": [] + }, + { + "id": "5720", + "type": "gene", + "text": "The virus encodes a 40 - kDa protein , tax , that is important for the immortalization of T cells .", + "entities": [ + "tax" + ] + }, + { + "id": "5721", + "type": "gene", + "text": "We have obtained the human EP4 receptor gene sequence and determined its structure relative to EP4R cDNA synthesized from peripheral blood lymphocytes .", + "entities": [ + "human EP4 receptor gene sequence", + "EP4R cDNA" + ] + }, + { + "id": "5722", + "type": "gene", + "text": "Both reduced spontaneous locomotor activity in mice , protected them from death from amphetamine induced toxicity , prolonged hexobarbitone sleeping time and caused a depletion of catecholamines from various organs of the rat .", + "entities": [] + }, + { + "id": "5723", + "type": "gene", + "text": "Ectopic ACTH syndrome and medullary thyroid carcinoma .", + "entities": [ + "ACTH" + ] + }, + { + "id": "5724", + "type": "gene", + "text": "Information on conserved noncoding sequences will help in studies on the regulation of the pro alpha 1 ( II ) collagen gene .", + "entities": [ + "pro alpha 1 ( II ) collagen gene" + ] + }, + { + "id": "5725", + "type": "gene", + "text": "Follow - up controls of luteinizing hormone ( LH ) , follicle stimulating hormone ( FSH ) , prolactin ( HPRL ) , oestradiol ( E2 ) , progesterone ( P ) and testosterone ( T ) in the catabolic and healing phase of burn disease .", + "entities": [ + "luteinizing hormone", + "LH", + "follicle stimulating hormone", + "FSH", + "prolactin", + "HPRL" + ] + }, + { + "id": "5726", + "type": "gene", + "text": "Here , we report that a transfected Chinese hamster ovary ( CHO ) cell line expressing a murine CD4 fragment containing the first two N - terminal domains secretes both monomeric molecules and disulfide - linked multimers .", + "entities": [ + "murine CD4 fragment" + ] + }, + { + "id": "5727", + "type": "gene", + "text": "Dissociative anesthetics 2 - ( o - chlorophenyl ) - 2 - methyl - amino cyclohexane HCL ( CI - 581 )", + "entities": [] + }, + { + "id": "5728", + "type": "gene", + "text": "In addition , this kinase is well conserved evolutionarily , ubiquitously expressed , and its genes map to a position on human chromosome 1 frequently deleted in the late stages of tumorigenesis .", + "entities": [] + }, + { + "id": "5729", + "type": "gene", + "text": "Selective effect of pulmonary oedema on prostaglandin E2 pharmacokinetics in rat lung .", + "entities": [] + }, + { + "id": "5730", + "type": "gene", + "text": "The Man9 - mannosidase specificity of the cDNA construct was verified by the observation that all peptide sequences derived from a previously purified , catalytically active 49 - kDa fragment were found within the coding region .", + "entities": [ + "Man9 - mannosidase" + ] + }, + { + "id": "5731", + "type": "gene", + "text": "A comparison of the clinical profile of cavernous malformations with and without associated venous malformations .", + "entities": [] + }, + { + "id": "5732", + "type": "gene", + "text": "The amino acid sequences of the known largest subunits of DdRPs from different species contain highly conserved regions .", + "entities": [ + "DdRPs" + ] + }, + { + "id": "5733", + "type": "gene", + "text": "When tested with wild - type ( DBA / 2 ) p16 , both A134C and G232A BALB / c - specific variants of p16 were inefficient in their ability to inhibit the activity of cyclin D2 / CDK4 in kinase assays with retinoblastoma protein , suggesting this defective , inherited allele plays an important role in the genetic susceptibility of BALB / c mice for plasmacytoma induction and that p16 ( INK4a ) is a strong candidate for the Pctr1 locus .", + "entities": [ + "p16", + "p16", + "cyclin D2", + "CDK4", + "retinoblastoma protein", + "p16", + "INK4a", + "Pctr1 locus" + ] + }, + { + "id": "5734", + "type": "gene", + "text": "The combination of hydralazine hydrochloride and isosorbide dinitrate also improves survival , but direct comparison of both regimens provided evidence for a less favourable effect than that of the ACE inhibitors .", + "entities": [ + "ACE" + ] + }, + { + "id": "5735", + "type": "gene", + "text": "No ' TATA ' motif was identified near either the GABPalpha or ATPsynCF6 transcription start sites .", + "entities": [ + "GABPalpha", + "ATPsynCF6" + ] + }, + { + "id": "5736", + "type": "gene", + "text": "These findings suggest that direct cDNA mapping using fluorescence in situ hybridization provides an accurate and rapid approach to the definition of a transcribed map of the human genome .", + "entities": [] + }, + { + "id": "5737", + "type": "gene", + "text": "Use of serum thyroglobulin determination in the follow - up of differentiated carcinomas of the thyroid", + "entities": [ + "thyroglobulin" + ] + }, + { + "id": "5738", + "type": "gene", + "text": "The data imply that JAK / STAT signaling has a role in EBV - associated malignancies .", + "entities": [ + "JAK", + "STAT" + ] + }, + { + "id": "5739", + "type": "gene", + "text": "The high degree of sequence identity ( 96 % ) between hydrolase B and C , particularly in the 3 ' untranslated region , suggests that the genes encoding these two carboxylesterases evolved by duplication and divergence of a common ancestral gene .", + "entities": [ + "hydrolase B and C", + "carboxylesterases" + ] + }, + { + "id": "5740", + "type": "gene", + "text": "Thin - layer chromatographic methods were up - dated for pharmacokinetic studies of imipramine in plasma and urine .", + "entities": [] + }, + { + "id": "5741", + "type": "gene", + "text": "Identification of a proline - rich sequence in the CD2 cytoplasmic domain critical for regulation of integrin - mediated adhesion and activation of phosphoinositide 3 - kinase .", + "entities": [ + "CD2 cytoplasmic domain", + "integrin", + "phosphoinositide 3 - kinase" + ] + }, + { + "id": "5742", + "type": "gene", + "text": "65 - kilodalton protein phosphorylated by interleukin 2 stimulation bears two putative actin - binding sites and two calcium - binding sites .", + "entities": [ + "interleukin 2", + "actin - binding sites" + ] + }, + { + "id": "5743", + "type": "gene", + "text": "A study of the E . O . R . T . C .", + "entities": [] + }, + { + "id": "5744", + "type": "gene", + "text": "Finally , over a similar range of QO2 , oxygen extraction was greater in patients with ARDS compared to patients with non - ARDS respiratory failure ( r = - 0 . 67 and slope = - 0 . 62 vs r = - 0 . 45 and slope = - 0 . 35 ; p less than 0 . 05 ) .", + "entities": [] + }, + { + "id": "5745", + "type": "gene", + "text": "Because of a rapid development of the connective tissue scars , however , at the place of the destroyed glandular parenchyma areas , there is no normalization of the organ ' s structure and function by the 42d day .", + "entities": [] + }, + { + "id": "5746", + "type": "gene", + "text": "Alena is a nurse in Prague - - she dreams of higher wages and a trip across the ocean", + "entities": [] + }, + { + "id": "5747", + "type": "gene", + "text": "Hyperthyroidism is one of the numerous causes of infertility and recurrent abortion .", + "entities": [] + }, + { + "id": "5748", + "type": "gene", + "text": "Estrogen treatment in high doses is effective in reducing adult stature in constitutionally tall girls .", + "entities": [] + }, + { + "id": "5749", + "type": "gene", + "text": "A similar phenomenon has been reported in a few humans .", + "entities": [] + }, + { + "id": "5750", + "type": "gene", + "text": "We discuss these results with respect to the transcriptional induction of the HNF - 3 alpha gene in respiratory epithelium during embryogenesis .", + "entities": [ + "HNF - 3 alpha gene" + ] + }, + { + "id": "5751", + "type": "gene", + "text": "Moreover , glucan synthase activity , which is activated by Rho1p , was significantly reduced in the deltabem4 mutant .", + "entities": [ + "glucan synthase", + "Rho1p", + "deltabem4 mutant" + ] + }, + { + "id": "5752", + "type": "gene", + "text": "Homology was also detected between the putative transit peptide sequence of cysteine synthase C and other mitochondrion - targeting leader sequences .", + "entities": [ + "cysteine synthase C" + ] + }, + { + "id": "5753", + "type": "gene", + "text": "In vitro translation of the mTRF1 cDNA resulted in a 56 kDa protein that binds to TTAGGG repeat arrays .", + "entities": [ + "mTRF1 cDNA" + ] + }, + { + "id": "5754", + "type": "gene", + "text": "mTRF1 displayed the same sequence specificity as hTRF1 , preferring arrays of TTAGGG repeats as a binding substrate over TTAGGC and TTGGGG repeats .", + "entities": [ + "mTRF1", + "hTRF1" + ] + }, + { + "id": "5755", + "type": "gene", + "text": "CTF1alpha , expressed in Escherichia coli , showed specific binding to the palindrome 2 DNA fragment but not to palindrome 1 or mutant palindrome 2 DNA fragments , suggesting specific binding of CTF1alpha to palindrome 2 .", + "entities": [ + "CTF1alpha", + "CTF1alpha" + ] + }, + { + "id": "5756", + "type": "gene", + "text": "STUDY DESIGN : Fine needle aspiration cytologic smears from 21 cases of invasive lobular carcinoma ( ILC ) of breast were subjected to detailed cytomorphologic analysis .", + "entities": [] + }, + { + "id": "5757", + "type": "gene", + "text": "A highly hydrophobic sequence located near the carboxyl - terminal extremity of the molecule most likely constitutes the anchor to the plasma membrane .", + "entities": [] + }, + { + "id": "5758", + "type": "gene", + "text": "In order to overcome the false positive readings that are possible in sphincter manometry , we proposed to use secretin stimulated endoscopic ultrasound ( SSEUS ) to measure pancreatic ductal response as an adjunctive method to aid and supplement the diagnosis .", + "entities": [ + "secretin" + ] + }, + { + "id": "5759", + "type": "gene", + "text": "RESULTS : The medians of average daily CD34 + cell yields for patients who received paclitaxel plus CY , CE , and CEP with G - CSF were 12 . 9 , 11 . 03 , and 5 . 37 x 10 ( 6 ) / kg , respectively , compared with 2 . 02 x 10 ( 6 ) / kg in the reference group that received CY with G - CSF ( P = < . 0001 , . 002 , and . 09 , respectively ) .", + "entities": [ + "CD34 +", + "G - CSF", + "G - CSF" + ] + }, + { + "id": "5760", + "type": "gene", + "text": "The already elevated prolactin levels in nursing women were not influenced by chronic oestradiol administration .", + "entities": [ + "prolactin" + ] + }, + { + "id": "5761", + "type": "gene", + "text": "Changing and predicting doses of Cs137 irradiation", + "entities": [] + }, + { + "id": "5762", + "type": "gene", + "text": "The induction by pseudorabies virus of an IL - 6 construct containing the IL - 6 TATA box and the RNA start site ( \" initiator \" or Inr element ) but not the MRE region was also repressed by Dex in the presence of wild - type GR .", + "entities": [ + "IL - 6 construct", + "IL - 6 TATA box", + "wild - type GR" + ] + }, + { + "id": "5763", + "type": "gene", + "text": "Account was taken of noncellular and nonhuman elements in the smears ; they included mucus , Charcot - Layden crystals , pollen grains , vegetal fragments and fungi .", + "entities": [] + }, + { + "id": "5764", + "type": "gene", + "text": "The rat aldolase C gene encodes a glycolytic enzyme strongly expressed in adult brain .", + "entities": [ + "rat aldolase C gene" + ] + }, + { + "id": "5765", + "type": "gene", + "text": "In this study , we identified four distinct E2F complexes present in aged and senescent normal , human diploid fibroblasts .", + "entities": [ + "E2F complexes" + ] + }, + { + "id": "5766", + "type": "gene", + "text": "Thus , this reading frame was concluded to encode the precursor of mitochondrial fumarase .", + "entities": [ + "mitochondrial fumarase" + ] + }, + { + "id": "5767", + "type": "gene", + "text": "These contain a single 1977 - bp exon that encodes 900 bp of the 5 ' and 3 ' untranslated sequences in addition to a 1077 - bp open reading frame identical to that found in vascular smooth muscle cell AT1a receptor cDNAs .", + "entities": [ + "vascular smooth muscle cell AT1a receptor cDNAs" + ] + }, + { + "id": "5768", + "type": "gene", + "text": "In this way it is possible to simulate the growth function of the embryofetal curve of the length ' increase of man and the curve of the mass ' increase of rat .", + "entities": [] + }, + { + "id": "5769", + "type": "gene", + "text": "In serum - stimulated cells , the binding of NF - Y / CBF to TKC1 increased gradually , reaching a plateau at the S phase .", + "entities": [ + "NF - Y", + "CBF", + "TKC1" + ] + }, + { + "id": "5770", + "type": "gene", + "text": "The respiratory rate was 13 + / - 1 breaths / min with 52 + / - 4 % of the respiratory cycle spent in inspiration ; end - tidal CO2 pressure increased by 3 . 3 + / - 1 . 0 Torr during runs at SIP .", + "entities": [] + }, + { + "id": "5771", + "type": "gene", + "text": "Alveolar growth , contemporary with dental eruption , is sufficient to compensate possible hypotrophy of maxillary bone bases .", + "entities": [] + }, + { + "id": "5772", + "type": "gene", + "text": "Beg2 and Beg1 are regulated differently which may indicate variation in storage or utilization properties among the barley globulins .", + "entities": [ + "Beg2", + "Beg1", + "barley globulins" + ] + }, + { + "id": "5773", + "type": "gene", + "text": "Until now , each of these loci was considered to contain three genes ( for regulator , permease and alpha - glucosidase ) , but a fourth gene , presumably an extra alpha - glucosidase gene , was found at MAL1 adjacent to the usual cluster of three genes .", + "entities": [ + "regulator", + "permease", + "alpha - glucosidase", + "alpha - glucosidase gene", + "MAL1" + ] + }, + { + "id": "5774", + "type": "gene", + "text": "RESULTS : Statistically significant differences were obtained between group I and II concerning the number of patients in whom induced atrial fibrillation with conduction by the accessory pathway and RR < or = 250 msec was found ( 0 vs 6 , p = 0 . 0045 ) .", + "entities": [] + }, + { + "id": "5775", + "type": "gene", + "text": "These findings were reinforced by an analysis that was restricted to living donor transplants without acute rejection .", + "entities": [] + }, + { + "id": "5776", + "type": "gene", + "text": "Transcriptional regulation of the vacuolar H ( + ) - ATPase B2 subunit gene in differentiating THP - 1 cells .", + "entities": [ + "vacuolar H ( + ) - ATPase B2 subunit gene" + ] + }, + { + "id": "5777", + "type": "gene", + "text": "Alternative splicing of RNA transcripts encoded by the murine p105 NF - kappa B gene generates I kappa B gamma isoforms with different inhibitory activities .", + "entities": [ + "NF - kappa B", + "I kappa B gamma isoforms" + ] + }, + { + "id": "5778", + "type": "gene", + "text": "Mutagenesis of SNT1 ( IRS ) CX identified three classes of effector motifs within SNT critical for both sustained ERK activation and neuronal differentiation : 1 ) four phosphotyrosine motifs that mediate recruitment of Grb2 , 2 ) two phosphotyrosine motifs that mediate recruitment of Shp2 , and 3 ) a C - terminal motif that functions by helping to recruit Sos .", + "entities": [ + "SNT1", + "IRS", + "CX", + "SNT", + "ERK", + "Grb2", + "Shp2", + "Sos" + ] + }, + { + "id": "5779", + "type": "gene", + "text": "Glucocorticoid induced hypertension has been regarded as independent of sodium ( Na ) , in contrast to mineralocorticoid induced hypertension , which is Na + - dependent .", + "entities": [] + }, + { + "id": "5780", + "type": "gene", + "text": "In 26 patients with angina pectoris , the changes of LVEF , LVESV and PSP / LVESV were more sensitive for the detection of exercise - induced ischemia than the appearance of chest pain and the changes of ECG .", + "entities": [] + }, + { + "id": "5781", + "type": "gene", + "text": "Cloning of a human phosphoinositide 3 - kinase with a C2 domain that displays reduced sensitivity to the inhibitor wortmannin .", + "entities": [ + "human phosphoinositide 3 - kinase", + "C2" + ] + }, + { + "id": "5782", + "type": "gene", + "text": "Anoxia was introduced by perfusing the gill with water deprived of oxygen or by halting the water flow to the gill .", + "entities": [] + }, + { + "id": "5783", + "type": "gene", + "text": "Using an interspecific backcross panel , we localized both Gng3 and Gng3lg to the same locus on chromosome 19 .", + "entities": [ + "Gng3", + "Gng3lg" + ] + }, + { + "id": "5784", + "type": "gene", + "text": "Widening of the abdominal aortic wall on an ultrasound examination was the key to the incidental diagnosis of a clinically unsuspected type B dissection .", + "entities": [] + }, + { + "id": "5785", + "type": "gene", + "text": "Additional deletion mutations revealed a new , 67 - amino - acid functional domain within the proline - rich region of SLP - 76 , which we have termed the P - 1 domain .", + "entities": [ + "SLP - 76" + ] + }, + { + "id": "5786", + "type": "gene", + "text": "As an alternative approach to this question , we have studied the effects of ectopically expressed SHIP , SHP - 1 , or SHP - 2 SH2 - containing decoy proteins on Fc gamma RIIB1 signaling .", + "entities": [ + "SHIP", + "SHP - 1", + "SHP - 2", + "Fc gamma RIIB1" + ] + }, + { + "id": "5787", + "type": "gene", + "text": "Reperfusion caused a transient reduction in lactate production and a significant increase in LDH release .", + "entities": [ + "LDH" + ] + }, + { + "id": "5788", + "type": "gene", + "text": "The authors proposed that the highly convergent inputs to the entorhinal cortex indicate this region may be particularly important for selecting or compressing information .", + "entities": [] + }, + { + "id": "5789", + "type": "gene", + "text": "Transcriptional repression mediated by LysR - type regulator CatR bound at multiple binding sites .", + "entities": [ + "LysR - type regulator CatR" + ] + }, + { + "id": "5790", + "type": "gene", + "text": "These results suggest that beta - 1 may act as a tissue - specific , trans - acting regulator of the expression of the beta - zein gene in developing maize endosperm .", + "entities": [ + "beta - 1", + "beta - zein gene" + ] + }, + { + "id": "5791", + "type": "gene", + "text": "The splice acceptor site is ca .", + "entities": [] + }, + { + "id": "5792", + "type": "gene", + "text": "HRES has been found to be clinically useful in assessing histologic damage following pneumatic dilatation and in localizing the LES during the administration of intrasphincter botulinum toxin injection in the treatment of achalasia .", + "entities": [ + "botulinum toxin" + ] + }, + { + "id": "5793", + "type": "gene", + "text": "( anti - IIa ) and Holmer et al .", + "entities": [ + "anti - IIa" + ] + }, + { + "id": "5794", + "type": "gene", + "text": "Regulation of avian fibroblast growth factor receptor 1 ( FGFR - 1 ) gene expression during skeletal muscle differentiation .", + "entities": [ + "avian fibroblast growth factor receptor 1", + "FGFR - 1" + ] + }, + { + "id": "5795", + "type": "gene", + "text": "Similarly approximately 300 bp of sequence downstream of the translation terminator TGA of the beta - tubulin 2 ( BTU2 ) gene could substitute for the 3 ' region of the H4 - I gene .", + "entities": [ + "beta - tubulin 2", + "BTU2", + "H4 - I gene" + ] + }, + { + "id": "5796", + "type": "gene", + "text": "Results were supported by the agar diffusion method for Y . enterocolitica , whereas inhibition activity was not found for A . hydrophila .", + "entities": [] + }, + { + "id": "5797", + "type": "gene", + "text": "Two related studies conducted over a five week period measured and typed HLA - DQA1 from accumulated DNA on autopsy room and Forensic DNA Laboratory structures .", + "entities": [ + "HLA - DQA1" + ] + }, + { + "id": "5798", + "type": "gene", + "text": "After nitric oxide inhalation , the results showed moderate increases in PaO2 and SaO2 ( P > 0 . 05 ) and a significant decrease in Qs / Q tau ratio ( P < 0 . 01 ) .", + "entities": [] + }, + { + "id": "5799", + "type": "gene", + "text": "This element was used to screen an EMBL3 mouse genomic library .", + "entities": [] + }, + { + "id": "5800", + "type": "gene", + "text": "The DAP5 / p86 apoptotic form was more potent than DAP5 / p97 in these functional assays .", + "entities": [ + "DAP5", + "p86", + "DAP5", + "p97" + ] + }, + { + "id": "5801", + "type": "gene", + "text": "In contrast to the signaling triggered by surface Ig engagement in B lymphocytes , CD38 ligation did not appear to induce tyrosine phosphorylation of the src - like protein tyrosine kinases lyn , fyn , and btk , or of vav - and ras - GTPase - activating protein , nor did it induce detectable changes in cytosolic CA2 + concentrations .", + "entities": [ + "Ig", + "CD38", + "lyn", + "fyn", + "btk", + "vav - and ras - GTPase - activating protein" + ] + }, + { + "id": "5802", + "type": "gene", + "text": "Since the morphology of the lesions can mimic that of other cutaneous disorders , Bowen ' s disease is often not recognized initially .", + "entities": [] + }, + { + "id": "5803", + "type": "gene", + "text": "However the sequence surrounding the transcription start site CTCA ( + 1 ) TTCC was similar to the consensus CTCA ( + 1 ) NTCT ( N is any nucleoside ) for an initiator element found in terminal deoxynucleotidyltransferase and a number of other highly regulated genes .", + "entities": [ + "terminal deoxynucleotidyltransferase" + ] + }, + { + "id": "5804", + "type": "gene", + "text": "Three monopolar electrodes were inserted into the left and right lateral vestibulospinal tract ( LVST ) and medial vestibulospinal tract ( MVST ) of the C1 segment , to determine the pathway of axons .", + "entities": [] + }, + { + "id": "5805", + "type": "gene", + "text": "Effect of phenformin on gluconeogenesis in perfused rat liver .", + "entities": [] + }, + { + "id": "5806", + "type": "gene", + "text": "Studies on Coxsackie B Type 5 virus infections .", + "entities": [] + }, + { + "id": "5807", + "type": "gene", + "text": "An alternative method of UKM is proposed based on collecting a small fraction of spent dialysate flow for 3 consecutive dialyses .", + "entities": [] + }, + { + "id": "5808", + "type": "gene", + "text": "The patient initially attained complete remission ( CR1 ) with conventional chemotherapy and then relapsed 14 months later .", + "entities": [] + }, + { + "id": "5809", + "type": "gene", + "text": "Transfection of increasing amounts of delta5ERalpha expression vector into [ ERalpha + ] OS cells resulted in potentiation of E2 - stimulated ERELuc activity in a synergistic , dose - dependent manner .", + "entities": [ + "delta5ERalpha", + "ERalpha", + "ERELuc" + ] + }, + { + "id": "5810", + "type": "gene", + "text": "1 .", + "entities": [] + }, + { + "id": "5811", + "type": "gene", + "text": "Fentanyl , a prototypic mu - opiate receptor agonist , has been previously shown to produce a syndrome characterized by marked analgesia and locomotor stimulation as well as tachycardia , tachypnoea and behavioural arousal .", + "entities": [ + "mu - opiate receptor" + ] + }, + { + "id": "5812", + "type": "gene", + "text": "Cell 49 , 753 - 761 ] .", + "entities": [] + }, + { + "id": "5813", + "type": "gene", + "text": "An egg protein , lysozyme , is a still unlabeled additive currently used in cheese preparation .", + "entities": [ + "lysozyme" + ] + }, + { + "id": "5814", + "type": "gene", + "text": "Instead , TRPS1 potently and specifically represses transcriptional activation mediated by other GATA factors .", + "entities": [ + "TRPS1", + "GATA factors" + ] + }, + { + "id": "5815", + "type": "gene", + "text": "Transient expression of human and chicken progesterone receptors does not support alternative translational initiation from a single mRNA as the mechanism generating two receptor isoforms .", + "entities": [ + "human and chicken progesterone receptors" + ] + }, + { + "id": "5816", + "type": "gene", + "text": "The corresponding gene was identified in the GenBankTM data base by sequence alignment and termed RPS30A .", + "entities": [ + "RPS30A" + ] + }, + { + "id": "5817", + "type": "gene", + "text": "The percutaneous absorption of clindamycin was studied in healthy male volunteers , comparing two investigative clindamycin ( % w / v ) / tretinoin ( 0 . 025 % w / v ) gels , containing clindamycin phosphate ester and clindamycin HCl , respectively , relative to a clindamycin phosphate lotion ( 1 % clindamycin ; Dalacin T ) .", + "entities": [] + }, + { + "id": "5818", + "type": "gene", + "text": "Further , mutational analysis of NS5A assigned the SH3 - binding region to a proline - rich motif that is highly conserved among HCV genotypes .", + "entities": [ + "NS5A", + "SH3 - binding region" + ] + }, + { + "id": "5819", + "type": "gene", + "text": "Most of the patients presented with Transient Ischemic Attacks ( 64 % ) or Reversible Ischemic Neurologic Deficits ( 19 % ) .", + "entities": [] + }, + { + "id": "5820", + "type": "gene", + "text": "A one - week ulcer therapy with atropine and Vikalin ( Roter ) led to a significant ( p less than 0 . 01 ) reduction of the nocturnal proteolytic activity .", + "entities": [] + }, + { + "id": "5821", + "type": "gene", + "text": "Characterization of the transcription factor MTF - 1 from the Japanese pufferfish ( Fugu rubripes ) reveals evolutionary conservation of heavy metal stress response .", + "entities": [ + "transcription factor MTF - 1" + ] + }, + { + "id": "5822", + "type": "gene", + "text": "Gene expression occurs in a circadian rhythm and induced by light in leaves of dark - adapted plants .", + "entities": [] + }, + { + "id": "5823", + "type": "gene", + "text": "The temporal component lacked a mandibular fossa as well as articular eminence .", + "entities": [] + }, + { + "id": "5824", + "type": "gene", + "text": "Surprisingly , a C to G transversion at the first residue of the CAT pentanucleotide , which severely impairs the activity of both promoters , appears to increase affinity of the CAT binding protein .", + "entities": [ + "CAT pentanucleotide", + "CAT binding protein" + ] + }, + { + "id": "5825", + "type": "gene", + "text": "Immunofixation experiments of C4A and C4B demonstrate > 41 allotypes in the two classes of proteins .", + "entities": [ + "C4A", + "C4B" + ] + }, + { + "id": "5826", + "type": "gene", + "text": "Ultraviolet light - induced kinin formation in human skin .", + "entities": [ + "kinin" + ] + }, + { + "id": "5827", + "type": "gene", + "text": "Site - directed mutagenesis of binding sites for the repressor proteins BP1 and BP2 in the upstream portion of the beta globin gene flanking region led to a 4 - 6 fold increase in promoter activity .", + "entities": [ + "repressor proteins BP1", + "BP2", + "beta globin gene flanking region" + ] + }, + { + "id": "5828", + "type": "gene", + "text": "To further define the structural requirements for ZAP - 70 interaction with the TCR , we developed a binding assay using immobilized glutathione S - transferase fusion proteins containing the NH2 - and / or COOH - terminal SH2 domains of ZAP - 70 , and soluble synthetic peptides with the sequence of the cytoplasmic region of the TCR zeta chain ( TCR zeta cyt ) or individual TCR zeta and CD3 epsilon TAM motifs .", + "entities": [ + "ZAP - 70", + "TCR", + "glutathione S - transferase fusion proteins", + "COOH - terminal SH2 domains", + "ZAP - 70", + "TCR zeta chain", + "TCR zeta cyt", + "TCR zeta", + "CD3 epsilon TAM motifs" + ] + }, + { + "id": "5829", + "type": "gene", + "text": "Our results suggest that while many muscle gene E - boxes are capable of binding the previously characterized spectrum of MDF / bH - L - H heterodimers in vitro , MCK - L type E - boxes probably bind qualitatively different factors in vivo .", + "entities": [ + "MDF / bH - L - H heterodimers", + "MCK - L" + ] + }, + { + "id": "5830", + "type": "gene", + "text": "The incidence of fetal breathing movements ( 06 . 00 - 10 . 00 h ) decreased with increasing gestational age while fetal arterial concentrations of plasma PGE increased significantly over the same period of gestation .", + "entities": [] + }, + { + "id": "5831", + "type": "gene", + "text": "NIK - 244 suppressed coronary ligation - and digitalis - induced arrhythmias , and the minimum effective plasma concentrations for arrhythmias induced by 24 - h and 48 - h coronary ligation and digitalis were 0 . 41 + / - 0 . 10 ( by 1 mg / kg i . v . ) , 0 . 70 + / - 0 . 13 ( by 1 mg / kg i . v . ) , and 0 . 21 + / - 0 . 08 ( by 0 . 5 mg / kg i . v . ) microgram / ml , respectively ( mean + / - SD of the mean , n = 6 ) .", + "entities": [] + }, + { + "id": "5832", + "type": "gene", + "text": "The present study examined the effect of intensity , rate , and polarity on the spectral content of ABRs of 15 normal - hearing subjects .", + "entities": [] + }, + { + "id": "5833", + "type": "gene", + "text": "Large scale electronic structure calculations .", + "entities": [] + }, + { + "id": "5834", + "type": "gene", + "text": "Inhibition of phosphatidylinositol - 3 kinase did not have a significant effect on p53 conformation but did have a weak but significant effect on Tpo - enhanced viability .", + "entities": [ + "phosphatidylinositol - 3 kinase", + "p53", + "Tpo" + ] + }, + { + "id": "5835", + "type": "gene", + "text": "Improving fissure sealant quality : mechanical preparation and filling level .", + "entities": [] + }, + { + "id": "5836", + "type": "gene", + "text": "Transcription from the promoter containing the mutated direct repeats was increased greatly , consistent with the conclusion that these motifs functions in vivo to repress GPT gene expression .", + "entities": [ + "GPT gene" + ] + }, + { + "id": "5837", + "type": "gene", + "text": "Therefore , magnetic resonance imaging was used to determine liver volume in pediatric and adolescent patients , in whom systemic clearance of three model substrates [ lorazepam ( 0 . 03 mg / kg ) , antipyrine ( 10 mg / kg ) , and indocyanine green ( ICG ; 0 . 5 mg / kg ) ] was also determined .", + "entities": [] + }, + { + "id": "5838", + "type": "gene", + "text": "Elimination of Haemophilus influenzae type b meningitis after introduction of vaccination", + "entities": [] + }, + { + "id": "5839", + "type": "gene", + "text": "Evidence is presented that Leber ' s military aneurysm retinitis is not a separate entity but a special form of Coats ' disease .", + "entities": [] + }, + { + "id": "5840", + "type": "gene", + "text": "They also indicate that direct interactions between C / EBPs and specific Ets family members , together with GATA - 1 , are important for eosinophil lineage determination .", + "entities": [ + "C / EBPs", + "Ets", + "GATA - 1" + ] + }, + { + "id": "5841", + "type": "gene", + "text": "The nucleotide sequence of 22 , 846 bp of the left arm of chromosome IV is described .", + "entities": [] + }, + { + "id": "5842", + "type": "gene", + "text": "In retrospect , the diagnoses were reconsidered applying strict criteria .", + "entities": [] + }, + { + "id": "5843", + "type": "gene", + "text": "The MVV - value is under the predicted level in the case of 67 - 76 percent .", + "entities": [] + }, + { + "id": "5844", + "type": "gene", + "text": "Sequences required for interaction of mu2 and CTLA - 4 were localized to residues , 161TTGVY in CTLA - 4 ; this sequence is N - terminal to , but overlaps with , a previously identified SH2 binding motif , 165YVKM , involved in CTLA - 4 signaling .", + "entities": [ + "mu2", + "CTLA - 4", + "CTLA - 4", + "SH2 binding motif", + "CTLA - 4" + ] + }, + { + "id": "5845", + "type": "gene", + "text": "Use of radioactive isotopes in the chemistry of proteins", + "entities": [] + }, + { + "id": "5846", + "type": "gene", + "text": "Ca2 + decreased Zn2 + binding in S100 beta but it did not influence binding to MRP14 , suggesting that the Zn2 + binding site was distinct from and independent of the two Ca2 + binding domains .", + "entities": [ + "S100 beta", + "MRP14" + ] + }, + { + "id": "5847", + "type": "gene", + "text": "We conclude that DNA ploidy is a major objective prognostic factor and therapeutic determinant for endometrial carcinoma .", + "entities": [] + }, + { + "id": "5848", + "type": "gene", + "text": "A liquid chromatographic method is described for analysis of beta - carotene in medical food .", + "entities": [] + }, + { + "id": "5849", + "type": "gene", + "text": "DMCM also permits extension of the possibilities of obtaining and transplanting donor organs .", + "entities": [] + }, + { + "id": "5850", + "type": "gene", + "text": "Transactivation of the HIV - 1 LTR by T3R alpha and several receptor mutants revealed that the 50 - amino - acid N - terminal A / B region of T3R alpha , known to interact with the basal transcription factor TFIIB , is critical for activation of both Tat - dependent and Tat - independent responsive sequences of the LTR .", + "entities": [ + "HIV - 1 LTR", + "T3R alpha", + "T3R alpha", + "basal transcription factor TFIIB", + "Tat", + "Tat" + ] + }, + { + "id": "5851", + "type": "gene", + "text": "Substitution of bulky hydrophobic residues with charged residues within PEP1 affects the fusion activity of the S protein without affecting processing and surface expression .", + "entities": [ + "PEP1", + "S protein" + ] + }, + { + "id": "5852", + "type": "gene", + "text": "The author gives an account of antipsychotic , analgetic , myorelaxing and vasodilatating effects of some calcium antagonists , and their clinical application is discussed .", + "entities": [] + }, + { + "id": "5853", + "type": "gene", + "text": "The residue functions , R ( t ) , for C - 11 CPZ and In - 113m transferrin were plotted against time for selected areas of interest , and the CPZ area - weighted extraction , E ( t ) , was computed for the same areas every 250 msec using the formula : E ( t ) = [ RT ( t ) - RR ( t ) ] / [ 1 - RR ( t ) ] , where RT and RR are the normalized residue functions for CPZ and transferrin , respectively .", + "entities": [ + "transferrin", + "transferrin" + ] + }, + { + "id": "5854", + "type": "gene", + "text": "Dorsal foot TcpO2 was measured by using oxygen - sensing electrodes with surface temperatures of 42 degrees C and 45 degrees C ; in theory , changes in sympathetic activity should affect vasomotor tone and TcpO2 in skin beneath an electrode at 42 degrees C ( submaximal vasodilation ) , but not at 45 degrees C ( maximal vasodilation ) .", + "entities": [] + }, + { + "id": "5855", + "type": "gene", + "text": "Unrecognized amnionitis and prematurity : a preliminary report .", + "entities": [] + }, + { + "id": "5856", + "type": "gene", + "text": "CPT - 11 was administered as a 30 - minute i . v . infusion at a dose of 350 mg / m2 diluted in 250 ml normal saline every 3 weeks .", + "entities": [] + }, + { + "id": "5857", + "type": "gene", + "text": "Eucaryotic transcription factors that stimulate RNA polymerase II by increasing the efficiency of elongation of specifically or randomly initiated RNA chains have been isolated and characterized .", + "entities": [ + "RNA polymerase II" + ] + }, + { + "id": "5858", + "type": "gene", + "text": "Supplementary Phase Contraste RSE ( \" Rapid Sequential Excitation \" ) sequences were carried out in 29 patients .", + "entities": [] + }, + { + "id": "5859", + "type": "gene", + "text": "Thrombophlebitis and pulmonary embolism in congenital factor XII deficiency", + "entities": [ + "factor XII" + ] + }, + { + "id": "5860", + "type": "gene", + "text": "In this paper the tyrosine dephosphorylating enzymes , the protein - tyrosine phosphatases ( PTPs ) , are studied which can be grouped into two subfamilies , the soluble PTPs and the receptor PTPs ( RPTPs ) .", + "entities": [ + "protein - tyrosine phosphatases", + "PTPs", + "soluble PTPs", + "receptor PTPs", + "RPTPs" + ] + }, + { + "id": "5861", + "type": "gene", + "text": "The moduli of elasticity of the gray and white matter were 3 . 4 + / - 1 . 4 kPa ( mean + / - standard deviation ) and 3 . 4 + / - 0 . 9 kPa in the axial section , 3 + / - 0 . 3 kPa and 3 . 5 + / - 0 . 5 kPa in the frontal section , and 3 . 5 + / - 0 . 9 kPa and 2 . 8 + / - 0 . 4 kPa in the sagittal section , respectively .", + "entities": [] + }, + { + "id": "5862", + "type": "gene", + "text": "Hematopoietic system in streptococcal allergy .", + "entities": [] + }, + { + "id": "5863", + "type": "gene", + "text": "Collectively , our findings demonstrate that SF - 1 plays a key role in controlling the basal and cAMP - stimulated expression of the StAR gene .", + "entities": [ + "SF - 1", + "StAR gene" + ] + }, + { + "id": "5864", + "type": "gene", + "text": "Following seven days ' incubation both at 20 degrees C and 28 degrees C , Ae . vexans nip . was capable of transmitting the virus .", + "entities": [] + }, + { + "id": "5865", + "type": "gene", + "text": "Analysis of cell cycle proteins showed that 24 h of lovastatin treatment in the control cells caused an elevation in the levels of the cyclin - dependent kinase inhibitor p27 ( kip1 ) , inhibition of both cyclin E - and cyclin A - dependent kinase activity , and decreased levels of hyperphosphorylated retinoblastoma protein ( pRb ) .", + "entities": [ + "cyclin - dependent kinase", + "p27", + "kip1", + "cyclin E - and cyclin A - dependent kinase", + "retinoblastoma protein", + "pRb" + ] + }, + { + "id": "5866", + "type": "gene", + "text": "Our data , combined with those of Hershey and co - workers , suggest that mammalian eIF3 is composed of at least 10 subunits : p170 , p116 ( hPrt1 ) , p110 , p66 , p48 , p47 , p44 , p40 , p36 , and p35 .", + "entities": [ + "mammalian eIF3", + "p170", + "p116", + "hPrt1", + "p110", + "p66", + "p48", + "p47", + "p44", + "p40", + "p36", + "p35" + ] + }, + { + "id": "5867", + "type": "gene", + "text": "Using a polymerase chain reaction - based approach , we cloned a 150 - base pair fragment of a new sialymotif from human placenta mRNA , which was then used as a probe to clone the complete coding sequence of the corresponding gene from a cDNA library .", + "entities": [] + }, + { + "id": "5868", + "type": "gene", + "text": "Deletion analysis was carried out within a part of the 5 ' - flanking region showing homology to the upstream region of the yeast CYC1 gene .", + "entities": [ + "yeast CYC1 gene" + ] + }, + { + "id": "5869", + "type": "gene", + "text": "The effect of MIB on the dose - response curve of externally applied noradrenaline was also studied .", + "entities": [] + }, + { + "id": "5870", + "type": "gene", + "text": "Analysis of the rate constants indicated that the isomerization rate k12 was approximately equal to the apparent degradation rate of the delta 3 ester kdeg , and slower than the hydrolysis rate of the delta 2 ester k24 .", + "entities": [] + }, + { + "id": "5871", + "type": "gene", + "text": "Primary infection is usually managed conservatively .", + "entities": [] + }, + { + "id": "5872", + "type": "gene", + "text": "Clin .", + "entities": [] + }, + { + "id": "5873", + "type": "gene", + "text": "To assess the maximum oxygen uptake ( V ' O2 max ) of Hong Kong Chinese children and to explore its association with respiratory illnesses , we conducted the Multistage Fitness Test ( MFT ) , a 20 - m shuttle run test , in 1 , 427 schoolchildren aged between 8 - 12 years .", + "entities": [] + }, + { + "id": "5874", + "type": "gene", + "text": "When phosphorylation of exogenous peptide substrates was measured as a function of receptor self - phosphorylation , tyrosine kinase activity was found to be enhanced two to threefold at 1 - 2 mol of phosphate per mol of receptor .", + "entities": [ + "tyrosine kinase" + ] + }, + { + "id": "5875", + "type": "gene", + "text": "M . M . C . was used for 2 . 5 minutes in 44 cases ( 20 HR patients , 24 LR patients ) , and for 5 minutes in 66 cases ( 46 HR patients , 20 LR patients ) .", + "entities": [] + }, + { + "id": "5876", + "type": "gene", + "text": "Our results are reassuring and we therefore advise that in patients undergoing free jejunum flap reconstruction of the hypopharyngo - esophageal tract voice restoration should be attempted by placing a voice prosthesis through a secondary tracheo - esophageal puncture and providing intensive speech training .", + "entities": [] + }, + { + "id": "5877", + "type": "gene", + "text": "The TATA box - binding protein ( TBP ) plays an essential role in transcription by all three eukaryotic nuclear RNA polymerases , polymerases ( Pol ) I , II , and III .", + "entities": [ + "TATA box - binding protein", + "TBP", + "nuclear RNA polymerases", + "polymerases ( Pol ) I , II , and III" + ] + }, + { + "id": "5878", + "type": "gene", + "text": "In an attempt to investigate whether the intergenic region between the oleosin and a second open reading frame ( ORFII ) in Brassica napus ( L . ) is a divergent promoter , and also to characterize the ORFII , cDNA clones homologous to ORFII were isolated from a leaf cDNA library .", + "entities": [ + "oleosin", + "ORFII", + "cDNA clones homologous to ORFII" + ] + }, + { + "id": "5879", + "type": "gene", + "text": "Histiocytic panniculitis was observed in biopsy specimens with cytophagocytosis .", + "entities": [] + }, + { + "id": "5880", + "type": "gene", + "text": "A correlation coefficient was used for assessing the similarity of each map pattern with the normal mean IQRST map .", + "entities": [] + }, + { + "id": "5881", + "type": "gene", + "text": "Here , we have more closely investigated transactivation of the human HSP70 promoter by Myb proteins .", + "entities": [ + "human HSP70 promoter", + "Myb proteins" + ] + }, + { + "id": "5882", + "type": "gene", + "text": "Penicillinase production in Staphylococcus aureus strains of clinical importance .", + "entities": [ + "Penicillinase" + ] + }, + { + "id": "5883", + "type": "gene", + "text": "Northern blot analysis indicates that AHA2 mRNA relative to total cellular RNA is expressed at significantly higher levels in root tissue as compared with shoot tissue .", + "entities": [ + "AHA2 mRNA" + ] + }, + { + "id": "5884", + "type": "gene", + "text": "Sequence analyses of sos2 mutant alleles reveal that both the N - terminal catalytic domain and the C - terminal regulatory domain of SOS2 are functionally essential .", + "entities": [ + "sos2 mutant alleles", + "SOS2" + ] + }, + { + "id": "5885", + "type": "gene", + "text": "The mobility shift of both of these proteins is abolished by treatment with inhibitors of PKC or mitogen - activated protein kinase / extracellular signal - related kinase kinase .", + "entities": [ + "PKC", + "mitogen - activated protein kinase", + "extracellular signal - related kinase kinase" + ] + }, + { + "id": "5886", + "type": "gene", + "text": "Both HEF1 and Cas were found to complex with the related adhesion focal tyrosine kinase ( RAFTK ) , and when tyrosine phosphorylated , with the adapter molecule CrkL .", + "entities": [ + "HEF1", + "Cas", + "related adhesion focal tyrosine kinase", + "RAFTK", + "CrkL" + ] + }, + { + "id": "5887", + "type": "gene", + "text": "A consensus sequence indicates a highly conserved lysine residue , K120 of endonuclease III or K241 of Ogg1 , respectively .", + "entities": [ + "endonuclease III", + "Ogg1" + ] + }, + { + "id": "5888", + "type": "gene", + "text": "In contrast , AP - 2 binding activity was significantly greater in T47D cells , and Western blots confirmed increased AP - 2 protein levels in these cells .", + "entities": [ + "AP - 2", + "AP - 2 protein" + ] + }, + { + "id": "5889", + "type": "gene", + "text": "Serum gamma glutamyltransferase in the diagnosis of liver disease in cattle .", + "entities": [ + "Serum gamma glutamyltransferase" + ] + }, + { + "id": "5890", + "type": "gene", + "text": "When the E1A N - terminus is used as a competitor in squelshing experiments it abolishes CBP - induced activation of E2F1 / DP1 , whereas an E1A mutant lacking CBP binding ability fails to do so .", + "entities": [ + "E1A N - terminus", + "CBP", + "E2F1", + "DP1", + "E1A mutant", + "CBP" + ] + }, + { + "id": "5891", + "type": "gene", + "text": "Antibodies raised against a C - terminal portion of Sec31A co - precipitate Sec13 and inhibit ER - Golgi transport of temperature - arrested vesicular stomatitis G protein in a semi - intact cell assay .", + "entities": [ + "Sec31A", + "Sec13", + "stomatitis G protein" + ] + }, + { + "id": "5892", + "type": "gene", + "text": "We observed that dephosphorylation severely inhibits the DNA - binding ability of C / EBP - delta and its transactivating potential increases in the presence of cellular phosphatase inhibitors , such as okadaic acid and sodium orthovanadate .", + "entities": [ + "C / EBP - delta" + ] + }, + { + "id": "5893", + "type": "gene", + "text": "The cellular rate of anticoagulant heparan sulfate proteoglycan ( HSPGact ) generation is determined by the level of a kinetically limiting microsomal activity , HSact conversion activity , which is predominantly composed of the long sought heparan sulfate D - glucosaminyl 3 - O - sulfotransferase ( 3 - OST ) ( Shworak , N .", + "entities": [ + "anticoagulant heparan sulfate proteoglycan", + "HSPGact", + "heparan sulfate D - glucosaminyl 3 - O - sulfotransferase", + "3 - OST" + ] + }, + { + "id": "5894", + "type": "gene", + "text": "These data suggest that hypocitraturia in type I renal tubular acidosis may be due to a defect in proximal tubule function .", + "entities": [] + }, + { + "id": "5895", + "type": "gene", + "text": "On the other hand , subjects with air trapping ( residual volume ( RV ) / total lung capacity ( TLC ) > 37 % ) disclosed not only a higher n ( mit ) ( 0 . 63 + / - 0 . 17 versus 0 . 43 + / - 0 . 07 mt x microm ( - 2 ) , p < 0 . 05 ) but shorter sarcomeres ( L ( sar ) ) than subjects without this functional abnormality ( 2 . 08 + / - 0 . 16 to 2 . 27 + / - 0 . 15 microm , p < 0 . 05 ) .", + "entities": [] + }, + { + "id": "5896", + "type": "gene", + "text": "Determination of aortic distensibility and its variations in arterial hypertension .", + "entities": [] + }, + { + "id": "5897", + "type": "gene", + "text": "The incidence of tumours in young chickens .", + "entities": [] + }, + { + "id": "5898", + "type": "gene", + "text": "In a Hoosier Oncology Group randomized study involving extensive - disease SCLC patients , VIP was superior to etoposide / cisplatin with regard to median time to progression ( 6 . 6 v 5 . 8 months ) , median survival times ( 9 . 1 v 7 . 3 months ) , and 2 - and 3 - year survival rates ( 13 % v 5 % and 5 % v 0 % , respectively ) .", + "entities": [] + }, + { + "id": "5899", + "type": "gene", + "text": "In summary , DDC express receptors for a broad panel of cytokines , even receptors for cytokines whose effects on DC are still unknown ( i . e .", + "entities": [] + }, + { + "id": "5900", + "type": "gene", + "text": "Survival of 111 Indium - labelled autologous platelets was studied in 2 patients after correction of platelet count and was still found shortened .", + "entities": [] + }, + { + "id": "5901", + "type": "gene", + "text": "All corneal buttons were processed for histopathologic and electron microscopic studies .", + "entities": [] + }, + { + "id": "5902", + "type": "gene", + "text": "To identify these sites , Cdk2 - phosphorylated MARCKS was digested with lysyl endoprotease and analysed by electrospray MS .", + "entities": [ + "Cdk2", + "MARCKS", + "lysyl endoprotease" + ] + }, + { + "id": "5903", + "type": "gene", + "text": "This result suggests that phosphorylation of Thr 14 and / or Tyr 15 inhibits p34cdc2 kinase activity , in line with the location of these residues within the putative ATP binding site of the kinase .", + "entities": [ + "p34cdc2 kinase" + ] + }, + { + "id": "5904", + "type": "gene", + "text": "Three ORFs ( 9765orfR002 , 9765orfR011 and 9765orfR013 ) were found to be homologous with Schizosaccharomyces pombe polyadenylate binding protein , Escherichia coli hypothetical 38 . 1 - kDa protein in the BCR 5 ' region , and transcription regulatory protein Swi3 , respectively .", + "entities": [ + "polyadenylate binding protein", + "BCR", + "Swi3" + ] + }, + { + "id": "5905", + "type": "gene", + "text": "Enhancer activity requires both the AP - 1 site and these adjacent sequences .", + "entities": [ + "AP - 1 site" + ] + }, + { + "id": "5906", + "type": "gene", + "text": "However , F - SRC - 1 mutant lacking CBP - interacting domain still preserved enhancing activity .", + "entities": [ + "F - SRC - 1 mutant", + "CBP - interacting domain" + ] + }, + { + "id": "5907", + "type": "gene", + "text": "The present investigation has revealed that the distribution of the main fatty acids in Leptospira phospholipids is similar to their distribution in Leptospira neutral lipids with the exception of unsaturated fatty acid with 14 carbon atoms , occurring mainly in phospholipids .", + "entities": [] + }, + { + "id": "5908", + "type": "gene", + "text": "The eukaryotic cell cycle is governed in part by the periodic transcription of cyclin genes , whose protein products associate with and positively regulate the cyclin - dependent kinases .", + "entities": [ + "cyclin genes", + "cyclin - dependent kinases" + ] + }, + { + "id": "5909", + "type": "gene", + "text": "This report presents state - specific MMRs for 1987 - 1996 , focusing on persistent disparities in maternal mortality between black and white women .", + "entities": [] + }, + { + "id": "5910", + "type": "gene", + "text": "Characteristics of anesthesia and resuscitation in emergency lung surgery", + "entities": [] + }, + { + "id": "5911", + "type": "gene", + "text": "The vaccine used was known to be immunogenic for older children and adults .", + "entities": [] + }, + { + "id": "5912", + "type": "gene", + "text": "The human protein sequence exhibits a putative DNA - binding domain similar to that seen in rat HBP1 and shows homology with the activation and repressor domains previously demonstrated in the rat protein .", + "entities": [ + "rat HBP1" + ] + }, + { + "id": "5913", + "type": "gene", + "text": "To this end , we analyzed the phosphorylation status of a universal tyrosine kinase substrate , the transforming Shc adapter protein , in fibroblasts expressing the viral oncogene .", + "entities": [ + "tyrosine kinase", + "Shc adapter protein" + ] + }, + { + "id": "5914", + "type": "gene", + "text": "18F and 85Sr scintimetry in the study of primary arthropathies .", + "entities": [] + }, + { + "id": "5915", + "type": "gene", + "text": "Thus , we have identified a GRE sufficient to account for full glucocorticoid inducibility and an HNF - 1 site close to the promoter that are major determinants of transcriptional control of the Xenopus fibrinogen B beta subunit gene in cells from normal liver tissue .", + "entities": [ + "HNF - 1 site", + "Xenopus fibrinogen B beta subunit gene" + ] + }, + { + "id": "5916", + "type": "gene", + "text": "Transcripts from a second POU - domain gene , Oct - 25 , were present at low levels in oocytes and early embryos and were dramatically upregulated during early gastrulation .", + "entities": [ + "POU - domain gene", + "Oct - 25" + ] + }, + { + "id": "5917", + "type": "gene", + "text": "Lewis , N .", + "entities": [] + }, + { + "id": "5918", + "type": "gene", + "text": "Most of the phenomena of azotaemic osteodystrophy are encountered in simple vitamin D deficiency ; as in that condition , deficiency of 1 , 25 - dihydroxycholecalciferol may be of primary significance in causing secondary hyperparathyroidism in renal failure .", + "entities": [] + }, + { + "id": "5919", + "type": "gene", + "text": "However , vancomycin and fosfomycin , which revealed suboptimal in vitro bactericidal activity , proved as efficacious as penicillin G and imipenem in an experimental mode of murine gas gangrene .", + "entities": [] + }, + { + "id": "5920", + "type": "gene", + "text": "R .", + "entities": [] + }, + { + "id": "5921", + "type": "gene", + "text": "Histone acetylation levels in cells result from a dynamic equilibrium between competing histone acetylases and deacetylases .", + "entities": [ + "Histone", + "histone acetylases and deacetylases" + ] + }, + { + "id": "5922", + "type": "gene", + "text": "The design principle based on a uniform vibration mode is presented .", + "entities": [] + }, + { + "id": "5923", + "type": "gene", + "text": "The mustard chloroplast gene rps16 is split by an 887 bp group II ( or III ) intron .", + "entities": [ + "mustard chloroplast gene rps16" + ] + }, + { + "id": "5924", + "type": "gene", + "text": "With regard to nonhematologic toxicities , diarrhea , infection and elevated serum alkaline phosphatase of grade 3 or over were observed in 2 % of cycles , but were tolerable and reversible .", + "entities": [ + "serum alkaline phosphatase" + ] + }, + { + "id": "5925", + "type": "gene", + "text": "The cell cycle and transcriptional defects caused by taf17 ( slm7 - 1 ) are consistent with the role of TAF ( II ) s as modulators of transcriptional activation and may reflect a role for TAF17 in regulating activation by SBF and MBF .", + "entities": [ + "taf17", + "slm7 - 1", + "TAF ( II ) s", + "TAF17", + "SBF", + "MBF" + ] + }, + { + "id": "5926", + "type": "gene", + "text": "Giant pilomatrix carcinoma : report and review of the literature .", + "entities": [] + }, + { + "id": "5927", + "type": "gene", + "text": "Unexpectedly , Arg1 - expressing COS1 cells showed no significant proteinase activity to various synthesized substrates under neutral or acidic conditions in this study .", + "entities": [ + "Arg1" + ] + }, + { + "id": "5928", + "type": "gene", + "text": "The proteins encoded downstream of rpoN are known to negatively regulate sigma 54 activity .", + "entities": [ + "rpoN", + "sigma 54" + ] + }, + { + "id": "5929", + "type": "gene", + "text": "In rats , we examined the effect of an omentum wrapping on the vascularization of the trachea and on regeneration of the mucosal epithelium in the very early stage after free tracheal grafting .", + "entities": [] + }, + { + "id": "5930", + "type": "gene", + "text": "Remarkably , both TTD - A and XP - D defects are associated with subunits of TFIIH , a basal transcription factor with a second function in DNA repair .", + "entities": [ + "TFIIH" + ] + }, + { + "id": "5931", + "type": "gene", + "text": "Kf , c and CT ( referenced to the initial lung mass ) decreased linearly with reductions in lung mass % delta Kf , c = 1 . 26 - 0 . 98 % mass removed ( r = 0 . 90 , P less than 0 . 01 ) and % delta CT = - 3 . 99 - 0 . 98 % mass removed ( r = 0 . 82 , P less than 0 . 01 ) relationships that were not altered by blocker pretreatment . ( ABSTRACT TRUNCATED AT 250 WORDS )", + "entities": [] + }, + { + "id": "5932", + "type": "gene", + "text": "The accuracies of presence or absence of neuroblastoma were compared between 131I - MIBG imaging and several tumor markers .", + "entities": [] + }, + { + "id": "5933", + "type": "gene", + "text": "Inhibitor - 1 ( I - 1 ) and inhibitor - 2 ( I - 2 ) selectively inhibit type 1 protein serine / threonine phosphatases ( PP1 ) .", + "entities": [ + "Inhibitor - 1", + "I - 1", + "inhibitor - 2", + "I - 2", + "type 1 protein serine / threonine phosphatases", + "PP1" + ] + }, + { + "id": "5934", + "type": "gene", + "text": "Our study shows that the area of Alcoy is a medium MS risk region according to the thesis of Kurzke , although high MS areas may be found , thus confirming that MS distribution in southern Europe is not uniform .", + "entities": [] + }, + { + "id": "5935", + "type": "gene", + "text": "We speculate that mast cell degranulation may be involved in the pathogenesis of necrobiosis by altering fibroblast enzyme activity and / or producing prolonged inflammatory reactions .", + "entities": [] + }, + { + "id": "5936", + "type": "gene", + "text": "Nursing home discharges in clinical practice .", + "entities": [] + }, + { + "id": "5937", + "type": "gene", + "text": "Besides , it was considered that the NPF was a useful tool for activation of velopharyngeal activity by way of visual feed - back control .", + "entities": [] + }, + { + "id": "5938", + "type": "gene", + "text": "K .", + "entities": [] + }, + { + "id": "5939", + "type": "gene", + "text": "Alginate biosynthesis is controlled by a complex regulatory mechanism .", + "entities": [] + }, + { + "id": "5940", + "type": "gene", + "text": "Amisulpride 400 mg had several adverse effects on psychomotor and , although less severe , on cognitive performance on the fifth day only .", + "entities": [] + }, + { + "id": "5941", + "type": "gene", + "text": "Circulating thrombomodulin : current knowledge and future prospects", + "entities": [ + "thrombomodulin" + ] + }, + { + "id": "5942", + "type": "gene", + "text": "RESULTS : There is a considerable amount of variation between the results of TRA1 and TRA2 and between the results of both TRA ' s and the door - to - door survey .", + "entities": [] + }, + { + "id": "5943", + "type": "gene", + "text": "Northern analysis , to search for a pcbAB transcript , showed no distinct transcript and indicated severely degraded mRNA .", + "entities": [ + "pcbAB transcript" + ] + }, + { + "id": "5944", + "type": "gene", + "text": "We show here that the LIM domain homeobox protein isl - 1 activates the rat amylin promoter in both fibroblast and islet cell lines .", + "entities": [ + "isl - 1", + "rat amylin promoter" + ] + }, + { + "id": "5945", + "type": "gene", + "text": "The results revealed increased blood lead level associated with decreased blood haemoglobin and increased urinary excretion of delta amino levulinic acid .", + "entities": [ + "blood haemoglobin" + ] + }, + { + "id": "5946", + "type": "gene", + "text": "Multi drug regimens like C - MOPP , CHOP and BACOP led to high remission rates and in some cases probably also to a cure of the disease .", + "entities": [] + }, + { + "id": "5947", + "type": "gene", + "text": "A G22V mutant of M - Ras was constitutively active and its expression in an interleukin - 3 ( IL - 3 ) - dependent mast cell / megakaryocyte cell line resulted in increased survival in the absence of IL - 3 , increased growth in IL - 4 , and , at high expression levels , in factor - independent growth .", + "entities": [ + "G22V mutant", + "M - Ras", + "interleukin - 3", + "IL - 3", + "IL - 3", + "IL - 4" + ] + }, + { + "id": "5948", + "type": "gene", + "text": "A comparison among the 5 ' flanking regions encompassing the presumptive HS promoter of the soybean HS - protein genes demonstrated this region to be extremely homologous .", + "entities": [ + "HS promoter", + "soybean HS - protein genes" + ] + }, + { + "id": "5949", + "type": "gene", + "text": "Pharmacokinetic parameters were similar to values given in the literature for intravenous ( IV ) or intraarterial ( IA ) bolus MMC injections ( Tmax = 7 . 0 min following the beginning of MMC infusion , Vss = 0 . 57 1 / kg , C1 = 8 . 9 ml / min . kg , T1 / 2 alpha = 8 . 3 min , T1 / 2 beta = 58 . 6 min ) .", + "entities": [] + }, + { + "id": "5950", + "type": "gene", + "text": "The stimulus threshold for EER showed a less individual variation than amplitude .", + "entities": [] + }, + { + "id": "5951", + "type": "gene", + "text": "The author analyzes extensive own data based on study into particular features of cardiovascular disorders in chronic renal impairement with making use of modern diagnostic tools .", + "entities": [] + }, + { + "id": "5952", + "type": "gene", + "text": "Unlike other progenitor cells of the brain , SVZa progenitor cells have the capacity to divide even though they express a neuronal phenotype .", + "entities": [] + }, + { + "id": "5953", + "type": "gene", + "text": "No post - operative haemorrhages from the prostheses were observed .", + "entities": [] + }, + { + "id": "5954", + "type": "gene", + "text": "Time delay effects on the tensile bond strength developed by the Silicoater .", + "entities": [] + }, + { + "id": "5955", + "type": "gene", + "text": "For 228 of 425 deaths ( 54 % ) occurring among 26 100 people of known age in the Malumfashi area of northern Nigeria , data were collected on symptoms present prior to death .", + "entities": [] + }, + { + "id": "5956", + "type": "gene", + "text": "Interferon Regulatory Factor ( IRF ) - 1 has been characterized as an important growth regulatory and immunomodulatory transcription factor .", + "entities": [ + "Interferon Regulatory Factor ( IRF ) - 1" + ] + }, + { + "id": "5957", + "type": "gene", + "text": "3 ' - Methyl , 8 - methyl , and 8 - phenyl derivatives of 5 , 9 - dimethyl - 6 , 7 - benzomorphans .", + "entities": [] + }, + { + "id": "5958", + "type": "gene", + "text": "The number of bacteria in the lung , peripheral white blood cell and BAL fluid cell also decreased by the administration of FN .", + "entities": [ + "FN" + ] + }, + { + "id": "5959", + "type": "gene", + "text": "Holger v .", + "entities": [] + }, + { + "id": "5960", + "type": "gene", + "text": "An analysis of synthetic peptides revealed a minimal CTD sequence that is sufficient to bind to the second Rsp5 WW domain ( Rsp5 WW2 ) in vitro and in yeast two - hybrid assays .", + "entities": [ + "Rsp5 WW domain", + "Rsp5 WW2" + ] + }, + { + "id": "5961", + "type": "gene", + "text": "Shift - down experiments indicated that the 10 ( 4 ) - to 10 ( 5 ) - fold reduction in virus yield at the nonpermissive temperature was due to the disfunction of alpha TIF late in infection , presumably in virion maturation .", + "entities": [ + "alpha TIF" + ] + }, + { + "id": "5962", + "type": "gene", + "text": "We now show that regulation of flaN transcription in vivo depends on a sigma 54 promoter and two ftr elements located downstream of the transcription start site at + 86 ( ftr2 ) and + 120 ( ftr3 ) .", + "entities": [ + "flaN", + "sigma 54 promoter" + ] + }, + { + "id": "5963", + "type": "gene", + "text": "These cells were able to present influenza virus particles to HLA - DR1 - restricted T cell clones .", + "entities": [ + "HLA - DR1" + ] + }, + { + "id": "5964", + "type": "gene", + "text": "Expression of the human papillomavirus type 11 E5A protein from the E1E4 , E5 transcript .", + "entities": [ + "human papillomavirus type 11 E5A protein", + "E1E4 , E5 transcript" + ] + }, + { + "id": "5965", + "type": "gene", + "text": "After taking smears from lesions of the oral mucosa ( tongue , cheeks , palate ) and the contiguous denture surface by cotton wool swabs and inoculating them onto Sabouraud glucose agar and CHROMagar Candida , individual yeast species were identified by a germ tube , filamentous , and assimilation tests employing the commercial kit AuxaColor .", + "entities": [] + }, + { + "id": "5966", + "type": "gene", + "text": "Competition needs to be better studied , since in Central America and Caribean islands this kind of study has favored the biological control of planorbid species .", + "entities": [] + }, + { + "id": "5967", + "type": "gene", + "text": "Their chemical structures were elucidated as 1 alpha , 2 alpha - diacetoxy - 8 beta - isobutanoyloxy - 9 alpha - benzoyloxy - 13 - ( alpha - methyl ) butanoyloxy - 4 beta , 6 beta - dihydroxy - beta - dihydroagarofuran ( 1 ) , 1 alpha , 2 alpha - diacetoxy - 8 beta - ( beta - furancarbonyloxy ) - 9 alpha - benzoyloxy - 13 - isobutanoyloxy - 4 beta , 6 beta - dihydroxy - beta - dihydroagarofuran ( 2 ) and 1 alpha , 6 beta , 8 alpha , 13 - tetraacetoxy - 9 alpha - benzoyloxy - 2 alpha - hydroxy - beta - dihydroagarofuran ( 3 ) mainly by analyses NMR and MS spectral data .", + "entities": [] + }, + { + "id": "5968", + "type": "gene", + "text": "Pao2 increased from 15 . 5 + / - 5 . 6 kPa ( 116 + / - 42 mm Hg ) to 17 . 3 + / - 6 . 3 kPa ( 130 + / - 47 mm Hg ) ( P < 0 . 05 ) .", + "entities": [] + }, + { + "id": "5969", + "type": "gene", + "text": "Characterization of an EcR / USP heterodimer target site that mediates ecdysone responsiveness of the Drosophila Lsp - 2 gene .", + "entities": [ + "EcR", + "USP", + "Drosophila Lsp - 2 gene" + ] + }, + { + "id": "5970", + "type": "gene", + "text": "The flux rates of p - toluidine decreased as the pH value in the donor solution increased .", + "entities": [] + }, + { + "id": "5971", + "type": "gene", + "text": "2001 .", + "entities": [] + }, + { + "id": "5972", + "type": "gene", + "text": "Elevated IOP developed in 35 patients ( 44 eyes ) during the study .", + "entities": [] + }, + { + "id": "5973", + "type": "gene", + "text": "Letter : Salmonella detection", + "entities": [] + }, + { + "id": "5974", + "type": "gene", + "text": "OBJECTIVES : The objective of this review was to compare the effectiveness , safety and acceptability of the diaphragm with and without spermicide .", + "entities": [] + }, + { + "id": "5975", + "type": "gene", + "text": "This paper describes the advantages and limitations of the main study approaches used .", + "entities": [] + }, + { + "id": "5976", + "type": "gene", + "text": "Consequently functional mRNAs can be produced by endogenous RNA polymerase I .", + "entities": [ + "endogenous RNA polymerase" + ] + }, + { + "id": "5977", + "type": "gene", + "text": "The distribution of the sites of recombinational resolution is inversely correlated with that of the gradient of sequence divergence , with only approximately 7 % of the X recombinants resolved within the 3 ' third of the X blocks where two diverged Alu family repeats reside .", + "entities": [ + "Alu" + ] + }, + { + "id": "5978", + "type": "gene", + "text": "Western blot analysis of various bovine tissues with human NMT peptide antibody indicated a common prominent immunoreactive band with an apparent molecular mass of 48 . 5 - 50 kDa in all tissues .", + "entities": [ + "NMT peptide antibody" + ] + }, + { + "id": "5979", + "type": "gene", + "text": "To evaluate the effect of altitude on adolescent growth and development , three groups of healthy , well - nourished youth of similar socioeconomic status and ethnic grouping who resided at sea level ( n = 1262 subjects ) , mid - altitude ( n = 1743 subjects ) , and high altitude ( n = 1137 subjects ) were studied .", + "entities": [] + }, + { + "id": "5980", + "type": "gene", + "text": "Schnell , J .", + "entities": [] + }, + { + "id": "5981", + "type": "gene", + "text": "The backbone dynamics of residues located in the folded part of CRP2 ( LIM2 ) R122A have been characterized by proton - detected ( 15 ) N NMR spectroscopy .", + "entities": [ + "CRP2", + "LIM2", + "R122A" + ] + }, + { + "id": "5982", + "type": "gene", + "text": "State of the body in disorders of diurnal physiological rhythms and long - term hypokinesia", + "entities": [] + }, + { + "id": "5983", + "type": "gene", + "text": "RESULTS : CK - MB elevation was detected in 313 patients ( 18 . 7 % ) , with 1 - 3x in 12 . 8 % , 3 - 5x in 3 . 5 % and > 5x normal in 2 . 4 % of patients .", + "entities": [ + "CK", + "MB" + ] + }, + { + "id": "5984", + "type": "gene", + "text": "Animals that received DSP - 4 were significantly retarded in motor recovery compared with the saline group .", + "entities": [] + }, + { + "id": "5985", + "type": "gene", + "text": "To analyze the regulatory activity of Gtx , we first identified the optimal Gtx - binding sequence using an in vitro DNA - binding assay .", + "entities": [ + "Gtx", + "Gtx - binding sequence" + ] + }, + { + "id": "5986", + "type": "gene", + "text": "In reconstitution experiments , we first showed that expression in the RAW 264 . 7 cell line of C - terminal Src kinase ( Csk ) inhibited and that of a membrane - anchored , gain - of - function Csk abolished the Fc gamma R - mediated signaling that leads to phagocytosis in a kinase - dependent manner .", + "entities": [ + "C - terminal Src kinase", + "Csk", + "Csk", + "Fc gamma R" + ] + }, + { + "id": "5987", + "type": "gene", + "text": "The domains involved in superactivation appear to be a subset of those necessary to achieve synergistic activation .", + "entities": [] + }, + { + "id": "5988", + "type": "gene", + "text": "Using one of the six fragments ( CPK3 - 8 ) , we isolated a 2022 bp cDNA ( VrCDPK - 1 ) from a Vigna radiata lambda gt11 library .", + "entities": [ + "CPK3 - 8", + "2022 bp cDNA ( VrCDPK - 1 )" + ] + }, + { + "id": "5989", + "type": "gene", + "text": "51 . 9 % ( P = 0 . 0006 ) in the MMF versus the AZA groups , respectively .", + "entities": [] + }, + { + "id": "5990", + "type": "gene", + "text": "Clone pSRc200 hybrid selected an mRNA that on cell - free translation produced a 38 - kDa polypeptide .", + "entities": [] + }, + { + "id": "5991", + "type": "gene", + "text": "The detection success rate was determined for different markers using this MEK .", + "entities": [ + "MEK" + ] + }, + { + "id": "5992", + "type": "gene", + "text": "The induction of seizures in \" Papio papio \" following allylglycine alone or in combination with intermittent photic stimulation", + "entities": [] + }, + { + "id": "5993", + "type": "gene", + "text": "Argatroban may be more effective under low HC II conditions because of its potent inhibition of thrombin activity at sites of vascular wall damage .", + "entities": [ + "HC II", + "thrombin" + ] + }, + { + "id": "5994", + "type": "gene", + "text": "In previous work ( E .", + "entities": [] + }, + { + "id": "5995", + "type": "gene", + "text": "One cDNA clone designated NCoA - 62 , encoded a 62 , 000 - Da protein that is highly related to BX42 , a Drosophila melanogaster nuclear protein involved in ecdysone - stimulated gene expression .", + "entities": [ + "BX42" + ] + }, + { + "id": "5996", + "type": "gene", + "text": "The present study describes the cell volume dynamics in intact rat hearts , during ischemia and after reperfusion .", + "entities": [] + }, + { + "id": "5997", + "type": "gene", + "text": "Experience with the restoration of agglutination properties of non - agglutinating dysenterial cultures with the use of Rzhaninov ' s method", + "entities": [] + }, + { + "id": "5998", + "type": "gene", + "text": "However , the increase in biliary excretion did not compensate for the reduced elimination of bretylium and hexylsalicylic acid via the kidney .", + "entities": [] + }, + { + "id": "5999", + "type": "gene", + "text": "Up to now the number of patients examined is about 300 , additionally 6 persons who underwent binephrectomy .", + "entities": [] + }, + { + "id": "6000", + "type": "gene", + "text": "Amongst other qualities , the book ' s importance lies in the fact that it associates an elaborate theoretical construction with the empirical data , working within the possibilities provided by late 19th - century moral statistics .", + "entities": [] + }, + { + "id": "6001", + "type": "gene", + "text": "A limiting factor were disturbances in the system of energy transport ( creatine phosphate , creatine phosphokinase ) and of the calcium pump ( Ca + + - ATPase of the sarcoplasmic reticulum , SPR ) , which evidently led to a decrease of the inotropic properties of the myocardium at 70 % restriction of coronary blood flow .", + "entities": [ + "creatine phosphokinase", + "Ca + + - ATPase" + ] + }, + { + "id": "6002", + "type": "gene", + "text": "Aspirin intolerance : unaltered susceptibility of platelet cyclo - oxygenase to inhibition by aspirin in vitro .", + "entities": [ + "platelet cyclo - oxygenase" + ] + }, + { + "id": "6003", + "type": "gene", + "text": "Furthermore , addition of B - Myb - glutathionine S - transferase fusion protein inhibited complex formation .", + "entities": [ + "B - Myb", + "glutathionine S - transferase" + ] + }, + { + "id": "6004", + "type": "gene", + "text": "The minimum and essential subunits for RNA synthesis have not yet been identified .", + "entities": [] + }, + { + "id": "6005", + "type": "gene", + "text": "This article describes the collaborative care of the woman participating in maternal blood donation for intrauterine transfusion .", + "entities": [] + }, + { + "id": "6006", + "type": "gene", + "text": "SRFDelta5 acts as a naturally occurring dominant negative regulatory mutant that blocks SRF - dependent skeletal alpha - actin , cardiac alpha - actin , smooth alpha - actin , SM22alpha , and SRF promoter - luciferase reporter activities .", + "entities": [ + "SRFDelta5", + "SRF", + "skeletal alpha - actin", + "cardiac alpha - actin", + "smooth alpha - actin", + "SM22alpha", + "SRF", + "luciferase" + ] + }, + { + "id": "6007", + "type": "gene", + "text": "The failures frequently were related to patient intolerance or poor mechanical fit and occurred in the first few days or first few months after insertion .", + "entities": [] + }, + { + "id": "6008", + "type": "gene", + "text": "A neonatal alloimmune thrombocytopenia with an HPA - 3a ( Baka ) incompatibility was confirmed .", + "entities": [ + "HPA - 3a" + ] + }, + { + "id": "6009", + "type": "gene", + "text": "These results indicate that mutL , miaA , and hfq expression could be regulated by multiple mechanisms , including degree of cotranscription from upstream genes , modulation of internal promoter strength , and by RNase E activity .", + "entities": [ + "mutL", + "miaA", + "hfq", + "RNase E" + ] + }, + { + "id": "6010", + "type": "gene", + "text": "These women should not be given the current estrogen PPI , which was designed to warn women of the risks of long - term estrogen use ; a PPI should be written specifically for patients receiving short courses .", + "entities": [] + }, + { + "id": "6011", + "type": "gene", + "text": "The DNA binding domain of NirA was expressed as a fusion protein with the glutathione S - transferase of Schistosoma japonicum .", + "entities": [ + "NirA", + "glutathione S - transferase" + ] + }, + { + "id": "6012", + "type": "gene", + "text": "Mutation of either the AP - 1 or the ets component of this site also prevented promoter activity in SMCs .", + "entities": [ + "AP - 1", + "ets" + ] + }, + { + "id": "6013", + "type": "gene", + "text": "Fifty - eight RMI ' s occurred in the placebo group as compared to only twenty in the AC group ( p less than 0 . 01 ) .", + "entities": [] + }, + { + "id": "6014", + "type": "gene", + "text": "The response chain in each component was maintained by food presentation under a fixed - ratio schedule .", + "entities": [] + }, + { + "id": "6015", + "type": "gene", + "text": "To examine the basis for the apparent differences in postsegregational killing between the two E . coli strains , transformation assays were carried out to determine the relative sensitivities of the strains to the ParE toxin protein .", + "entities": [ + "ParE toxin protein" + ] + }, + { + "id": "6016", + "type": "gene", + "text": "This information , together with estimation of the size of the deglycosylated A subunit relative to a series of C - terminal truncated TSHR ectodomain variants , places cleavage Site 1 in the vicinity of , or closely upstream to , residue 317 .", + "entities": [ + "C - terminal truncated TSHR ectodomain variants" + ] + }, + { + "id": "6017", + "type": "gene", + "text": "Proximal CBD was inversely correlated with bone alkaline phosphatase ( r = - 0 . 71 , p < 0 . 01 ) and intact PTH ( r = - 0 . 59 , p < 0 . 05 ) .", + "entities": [ + "bone alkaline phosphatase", + "PTH" + ] + }, + { + "id": "6018", + "type": "gene", + "text": "Traditional surgical exploration was followed by survey with a gamma - detecting probe .", + "entities": [] + }, + { + "id": "6019", + "type": "gene", + "text": "cDNA encoding a functional feline liver / bone / kidney - type alkaline phosphatase .", + "entities": [ + "feline liver / bone / kidney - type alkaline phosphatase" + ] + }, + { + "id": "6020", + "type": "gene", + "text": "The alterations of 5 - HT and 5 - HIAA levels in several regions of the brain under the conditions examined may indicate that IDPN ' s neurotoxicity primarily affects 5 - HT - containing neurones .", + "entities": [] + }, + { + "id": "6021", + "type": "gene", + "text": "We propose that Gly84 is part of a putative \" oxyanion hole \" involved in the stabilization of the transition state similar to the C group of the esterase / lipase family .", + "entities": [ + "C group", + "esterase", + "lipase" + ] + }, + { + "id": "6022", + "type": "gene", + "text": "Finally , the stability of the nucleotide binding function of the two proteins is similar as assessed by sensitivity to urea .", + "entities": [] + }, + { + "id": "6023", + "type": "gene", + "text": "The most common types of malformations were eye defects and open coeloms .", + "entities": [] + }, + { + "id": "6024", + "type": "gene", + "text": "Ruddell , M .", + "entities": [] + }, + { + "id": "6025", + "type": "gene", + "text": "The SEB1 homologue thus isolated , SEB2 , encodes a protein 53 % identical to Seb1p .", + "entities": [ + "SEB1", + "SEB2", + "Seb1p" + ] + }, + { + "id": "6026", + "type": "gene", + "text": "We show that the 5 ' UTR characteristic of testis - specific c - mos mRNA strongly represses translation relative to the translation of transcripts that contain a 5 ' UTR derived from beta - globin mRNA , and this is mainly due to the four uORFs .", + "entities": [ + "testis - specific c - mos mRNA", + "beta - globin mRNA" + ] + }, + { + "id": "6027", + "type": "gene", + "text": "BACKGROUND : Delineation of the morphologic aspects of age - related macular degeneration ( ARMD ) is helpful in correlation with the clinical features and may contribute to understanding the pathogenesis .", + "entities": [] + }, + { + "id": "6028", + "type": "gene", + "text": "The GAC1 gene encodes the regulatory subunit for a type 1 serine / threonine phosphoprotein phosphatase , Glc7 .", + "entities": [ + "GAC1 gene", + "type 1 serine / threonine phosphoprotein phosphatase", + "Glc7" + ] + }, + { + "id": "6029", + "type": "gene", + "text": "No increased tumor - related mortality was observed after a mean follow - up of 44 months .", + "entities": [] + }, + { + "id": "6030", + "type": "gene", + "text": "The shift to the nonpermissive temperature is accompanied by the loss of guanyl nucleotide - dependent activity of adenylylcyclase in vitro .", + "entities": [ + "adenylylcyclase" + ] + }, + { + "id": "6031", + "type": "gene", + "text": "Considering that the reactor is thoroughly mixed during each discharge and that LD50 = 0 . 9 values are nearly independent of E . coli concentrations in the range of 2 x 10 ( 3 ) < or = E coli / cfu mL ( - 1 ) < or = 3 x 10 ( 6 ) , we ascribe the nonexponential Pn decay of single - strain E . coli colonies to a shielding phenomenon where inactive cells protect the successively smaller numbers of viable cells in the EHD .", + "entities": [] + }, + { + "id": "6032", + "type": "gene", + "text": "The level of subclinical infection was 75 % among seropositive dogs .", + "entities": [] + }, + { + "id": "6033", + "type": "gene", + "text": "The interaction of zf4 - 6 with full - length 5 S RNA was far more sensitive to non - specific competitor concentration than was the zf4 - 7 : 5 S RNA interaction , suggesting that finger seven contributes to both affinity and specificity in this protein : RNA interaction .", + "entities": [ + "zf4 - 6", + "full - length 5 S RNA", + "zf4 - 7", + "5 S RNA" + ] + }, + { + "id": "6034", + "type": "gene", + "text": "The extraction recovery of Amphotericin B from the cerebrospinal fluid is higher than 90 % over the entire linear range .", + "entities": [] + }, + { + "id": "6035", + "type": "gene", + "text": "CONCLUSIONS : This retrospective uncontrolled study shows that in patients with type 1 HRS , terlipressin - induced improved renal function is associated with an increase in survival .", + "entities": [] + }, + { + "id": "6036", + "type": "gene", + "text": "We analyzed the modular organization of DNA polymerase beta and found that residues making contact with DNA phosphates were localized to five modules .", + "entities": [ + "DNA polymerase beta" + ] + }, + { + "id": "6037", + "type": "gene", + "text": "Digitalis glycosides or beta - receptor antagonists are not helpful in the therapy of this form of atrial fibrillation whereas class I antiarrhythmic drugs have been shown to be more effective .", + "entities": [ + "beta - receptor" + ] + }, + { + "id": "6038", + "type": "gene", + "text": "ESS type 1 , with FT3 low and FT4 and TSH normal , is the most frequent form .", + "entities": [ + "TSH" + ] + }, + { + "id": "6039", + "type": "gene", + "text": "A total of 1459 men aged 48 to 84 years , who were diagnosed for the first time by physicians as having BPH in 1994 and who had not received treatment , participated in the study .", + "entities": [] + }, + { + "id": "6040", + "type": "gene", + "text": "Most apneic events occurred during Stages I and II , and REM , but this proportion was less during the gamma OH study ( 77 . 9 + / - 8 . 9 % ) than during the control studies ( 92 . 3 + / - 1 . 9 and 95 . 9 + / - 2 . 2 % ) , apneas occurring even during SWS with gamma OH . ( ABSTRACT TRUNCATED AT 250 WORDS )", + "entities": [] + }, + { + "id": "6041", + "type": "gene", + "text": "A data base homology search revealed that the predicted ER1 amino acid sequence contains three regions of similarity to the rat and human proteins encoded by the metastasis - associated gene , mta1 , and two regions of similarity to the Caenorhabditis elegans sequence that is similar to mta1 .", + "entities": [ + "ER1", + "mta1", + "mta1" + ] + }, + { + "id": "6042", + "type": "gene", + "text": "The homologies between RAD16 , RAD54 and SNF2 are also shared by several additional , recently isolated yeast and Drosophila genes .", + "entities": [ + "RAD16", + "RAD54", + "SNF2" + ] + }, + { + "id": "6043", + "type": "gene", + "text": "The subjects were diagnosed on the basis of DSM - IV pathological gambling criteria and completed the Turkish Version of South Oaks Gambling Screen ( SOGS ) .", + "entities": [] + }, + { + "id": "6044", + "type": "gene", + "text": "Regional cerebral blood flow was measured using N - isopropyl - 123I - iodoamphetamine with single - photon emission computed tomography ( CT ) in 16 aged patients with noninsulin - dependent diabetes mellitus ( NIDDM , average age 72 . 8 years , average fasting plasma glucose 7 . 7 mmol / L ) , and 12 nondiabetic subjects ( 71 . 6 years , 5 . 3 mmol / L ) .", + "entities": [] + }, + { + "id": "6045", + "type": "gene", + "text": "AIM : To understand the role of nutritional status in cirrhotic patients without clinical porto - systemic encephalopathy ( PSE ) . METHODS : Fifty - one non - alcoholic patients with cirrhosis without PSE were studied prospectively and compared with 20 healthy volunteers .", + "entities": [] + }, + { + "id": "6046", + "type": "gene", + "text": "This report describes the identification of a gene of related function , SMD1 , located immediately 3 ' to PRP38 .", + "entities": [ + "SMD1", + "PRP38" + ] + }, + { + "id": "6047", + "type": "gene", + "text": "Using a battery of I kappa B alpha mutants , we show that ( i ) a dimer binds a single I kappa B alpha molecule , ( ii ) the acidic C - terminal region of I kappa B alpha is not required for protein - protein binding and does not mask the nuclear localization signal of the dimer , ( iii ) the same C - terminal region is required for inhibition of DNA binding , and ( iv ) this inhibition may be accomplished by direct interaction between the PEST - like region and the DNA - binding region of one of the subunits of the dimer .", + "entities": [ + "I kappa B alpha mutants", + "I kappa B alpha molecule", + "I kappa B alpha" + ] + }, + { + "id": "6048", + "type": "gene", + "text": "The calcitonin - induced tyrosine phosphorylation of HEF1 increased in a time - and dose - dependent manner .", + "entities": [ + "calcitonin", + "HEF1" + ] + }, + { + "id": "6049", + "type": "gene", + "text": "Adrenergic system activation , indicated by metanephrine / epinephrine ratio , increased with time in losing males , except that after one month of cohabitation , turnover returned to levels that equaled those of control animals .", + "entities": [] + }, + { + "id": "6050", + "type": "gene", + "text": "Two experiments were conducted to study the vacuous jaw movements induced in rats by acute administration of the monoamine - depleting agent reserpine .", + "entities": [] + }, + { + "id": "6051", + "type": "gene", + "text": "Approximately 65 % of the total cAMP - dependent phosphotransferase activity is recovered in particulate fractions of homogenates prepared from asynchronous populations of C . elegans .", + "entities": [ + "cAMP - dependent phosphotransferase" + ] + }, + { + "id": "6052", + "type": "gene", + "text": "These show that the collagen in this tissue is modified compared with that in tendon .", + "entities": [ + "collagen" + ] + }, + { + "id": "6053", + "type": "gene", + "text": "Herceptin , which recognizes the HER - 2 / neu antigen and has similar size ( 10 nm ) to G6 - ( 1B4M - Gd ) ( 256 ) , accumulated and internalized in the WIBC - 9 tumors more quickly than in the control MC - 5 tumors that progress with normal angiogenesis .", + "entities": [ + "HER - 2", + "neu" + ] + }, + { + "id": "6054", + "type": "gene", + "text": "In this study we describe that platelet - derived growth factor ( PDGF ) , 12 - O - tetradecanoyl - phorbol - acetate ( TPA ) , and forskolin induced CREB ( cAMP - responsive element - binding protein ) Ser - 133 phosphorylation with comparable magnitude and kinetics in NIH 3T3 cells .", + "entities": [ + "platelet - derived growth factor", + "PDGF", + "CREB", + "cAMP - responsive element - binding protein" + ] + }, + { + "id": "6055", + "type": "gene", + "text": "The majority of tumors occurred in the nasal cavities , although significant incidences were also found in the larynx , trachea and stem bronchi .", + "entities": [] + }, + { + "id": "6056", + "type": "gene", + "text": "Determination of transaminases with an autoanalyzer", + "entities": [] + }, + { + "id": "6057", + "type": "gene", + "text": "With the exception of mutants that remove the membrane anchor domain , all of the mutant glycoproteins retained the ability to cause fusion of CD4 - bearing cells .", + "entities": [ + "CD4" + ] + }, + { + "id": "6058", + "type": "gene", + "text": "In conclusion , USPIO - enhanced MRI data were capable to characterize tumor microvessel properties in this breast cancer model : microvascular permeability ( determined using USPIO ) correlated significantly with tumor grade .", + "entities": [] + }, + { + "id": "6059", + "type": "gene", + "text": "Furthermore , our data also show that , in addition to TEF - 1 , another HF - 1a - related factor may be recognized by the alpha - MHC gene EM element .", + "entities": [ + "TEF - 1", + "HF - 1a - related factor", + "alpha - MHC gene" + ] + }, + { + "id": "6060", + "type": "gene", + "text": "Further , Tax - mediated apoptosis was effectively prevented by ectopic expression of the p300 coactivator .", + "entities": [ + "Tax", + "p300 coactivator" + ] + }, + { + "id": "6061", + "type": "gene", + "text": "Human thyroid stimulator ( HTS ) in thyroid diseases", + "entities": [ + "Human thyroid stimulator", + "HTS" + ] + }, + { + "id": "6062", + "type": "gene", + "text": "The encoded polypeptide is similar in sequence to the ABA - 1 allergen of Ascaris , the gp15 / 400 ' ladder ' protein of Brugia malayi , Brugia pahangi and Wuchereria bancrofti , and a 15 - kDa antigen of Dirofilaria immitis .", + "entities": [ + "ABA - 1 allergen of Ascaris", + "gp15 / 400 ' ladder ' protein of Brugia malayi , Brugia pahangi and Wuchereria bancrofti", + "15 - kDa antigen of Dirofilaria immitis" + ] + }, + { + "id": "6063", + "type": "gene", + "text": "Specifically , recombination at HMR was used to produce rings that lacked the E and I silencers .", + "entities": [ + "HMR" + ] + }, + { + "id": "6064", + "type": "gene", + "text": "These mutations , when placed in a wild - type fliF background , had no mutant phenotype .", + "entities": [ + "wild - type fliF" + ] + }, + { + "id": "6065", + "type": "gene", + "text": "We conclude that , with autonomic nervous system activity intact , carotid chemoreceptor reflex activation can elicit an absolute reflexly mediated reduction in coronary blood flow in the normal , conscious dog , despite an increase in arterial pressure .", + "entities": [] + }, + { + "id": "6066", + "type": "gene", + "text": "Within the Strep . mutans group there was a highly - significant difference between Strep .", + "entities": [] + }, + { + "id": "6067", + "type": "gene", + "text": "mutans / Strep . cricetus ( p less than 0 . 01 ) with respect to mean clump size .", + "entities": [] + }, + { + "id": "6068", + "type": "gene", + "text": "A new Onchocerca species , a parasite of domestic cattle , in Senegal", + "entities": [] + }, + { + "id": "6069", + "type": "gene", + "text": "Results from the mechanism study have revealed that YY1 is able to inhibit transactivation mediated by either AP1 or the Sp1 - related protein , and YY1 suppressive activity is DNA binding dependent .", + "entities": [ + "YY1", + "AP1", + "Sp1 - related protein", + "YY1" + ] + }, + { + "id": "6070", + "type": "gene", + "text": "Reperfusion with normal blood in the beating , working hearts caused extensive structural damage , reduced reflow , and failed to restore contractility in any instance ( - 27 % systolic shortening , p less than 0 . 05 ) .", + "entities": [] + }, + { + "id": "6071", + "type": "gene", + "text": "The primary pancreatic insult seemed to be unaffected by the treatment , because neither the rise in plasma lipase nor the development of ascites or the extension of the pancreatic necrosis were diminished .", + "entities": [ + "plasma lipase" + ] + }, + { + "id": "6072", + "type": "gene", + "text": "Hp positive relatives of gastric cancer had a markedly higher prevalence of atrophy than those with Hp negativity without cancer relatives ( 29 vs .", + "entities": [] + }, + { + "id": "6073", + "type": "gene", + "text": "Kodak XV - 2 film is wrapped around a cylindrical water - filled phantom and the dose distribution is recorded .", + "entities": [] + }, + { + "id": "6074", + "type": "gene", + "text": "In humans , three tissue - specific plastin isoforms have been identified .", + "entities": [ + "tissue - specific plastin isoforms" + ] + }, + { + "id": "6075", + "type": "gene", + "text": "Monospecific antibodies , eluted from the beta - galactosidase fusion protein of either clone reacted with the U1 snRNP - specific A antigen .", + "entities": [ + "beta - galactosidase", + "U1 snRNP", + "A antigen" + ] + }, + { + "id": "6076", + "type": "gene", + "text": "Their afterglows are brighter than supernovae and therefore are called hypernovae .", + "entities": [] + }, + { + "id": "6077", + "type": "gene", + "text": "These findings suggest a novel ankyrin - independent role for LAD - 1 related to FGFR signaling .", + "entities": [ + "ankyrin", + "LAD - 1", + "FGFR" + ] + }, + { + "id": "6078", + "type": "gene", + "text": "Delta - aminolevulinic acid in physiological conditions and some diseases in children", + "entities": [] + }, + { + "id": "6079", + "type": "gene", + "text": "The aim of this study was to investigate the effects of nebulized ipratropium in patients with acute asthma in order to determine whether it augments the bronchodilator effect of a beta agonist drug .", + "entities": [] + }, + { + "id": "6080", + "type": "gene", + "text": "Measurement of the time constant of VO2 and oxygen pulse during constant work rate exercise are useful for the objective evaluation of the training effect of patients with COPD .", + "entities": [] + }, + { + "id": "6081", + "type": "gene", + "text": "Polyprotein processing in Southampton virus : identification of 3C - like protease cleavage sites by in vitro mutagenesis .", + "entities": [ + "3C - like protease" + ] + }, + { + "id": "6082", + "type": "gene", + "text": "Response durations were short .", + "entities": [] + }, + { + "id": "6083", + "type": "gene", + "text": "A gapped search with the C - terminal region of CDED / LIOR revealed a 36 - 41 % similarity to several proteins related to signal transduction and cell replication , such as ORC1 and KSR .", + "entities": [ + "CDED", + "LIOR", + "ORC1", + "KSR" + ] + }, + { + "id": "6084", + "type": "gene", + "text": "Serum alkaline phosphatase activity , bone mass measurements , dual energy x - ray absortiometric analysis of mineral density , and mechanical testing values in vertebrae and femora of the - D Sal animals did not significantly differ from those in + D Sal animals .", + "entities": [ + "Serum alkaline phosphatase" + ] + }, + { + "id": "6085", + "type": "gene", + "text": "It is suggested that a raised hydroxykynurenine / hydroxyanthranilic acid ratio does not necessarily indicate vitamin B6 deficiency but may represent a nonspecific response of tryptophan metabolism to stress .", + "entities": [] + }, + { + "id": "6086", + "type": "gene", + "text": "Removal of each of three contiguous segments from the N - terminal half specifically inhibits the formation of 5 . 8Ss rRNA , whereas deleting part of the C - terminal region of the protein only blocks the production of 18S rRNA .", + "entities": [ + "5 . 8Ss rRNA", + "18S rRNA" + ] + }, + { + "id": "6087", + "type": "gene", + "text": "As in the other three members whose gene expression is altered during tumorigenesis , PI12 expression was found to be down - regulated in tumor brain tissues and in two brain cancer cell lines : U - 87 MG and H4 .", + "entities": [ + "PI12" + ] + }, + { + "id": "6088", + "type": "gene", + "text": "After 1 . 5 years of such photoperiodic control , all ewes were blinded by bilateral orbital enucleation .", + "entities": [] + }, + { + "id": "6089", + "type": "gene", + "text": "Among mucus - secreting cells , the gastric gland mucous cells , Brunner ' s glands , accessory glands of pancreaticobiliary tract , and pancreatic ducts exhibiting gastric metaplasia are unique in that they express class III mucin identified by paradoxical Con A staining composed of periodate oxidation , sodium borohydride reduction , Con A , and horseradish peroxidase reaction .", + "entities": [ + "class III mucin", + "Con A", + "Con A", + "horseradish peroxidase" + ] + }, + { + "id": "6090", + "type": "gene", + "text": "Here we have determined the nucleotide sequence of 3 . 5 kb from the 3 ' end of delta gag to the 3 ' end of molecularly cloned proviral MH2 DNA , in order to elucidate the genetic structure of the virus and to compare it with other mht - and myc - containing oncogenic viruses as well as with the chicken proto - myc gene .", + "entities": [ + "delta gag", + "mht", + "myc", + "chicken proto - myc gene" + ] + }, + { + "id": "6091", + "type": "gene", + "text": "Overexpression of mcl - 1 is sufficient to protect against apoptosis , while transfection of a mcl - 1 antisense plasmid causes cell death .", + "entities": [ + "mcl - 1", + "mcl - 1" + ] + }, + { + "id": "6092", + "type": "gene", + "text": "Analysis of electrically evoked response ( EER ) in relation to the central visual pathway of the cat ( 1 ) .", + "entities": [] + }, + { + "id": "6093", + "type": "gene", + "text": "Mutational analysis of mammalian translation initiation factor 5 ( eIF5 ) : role of interaction between the beta subunit of eIF2 and eIF5 in eIF5 function in vitro and in vivo .", + "entities": [ + "mammalian translation initiation factor 5", + "eIF5", + "eIF2", + "eIF5", + "eIF5" + ] + }, + { + "id": "6094", + "type": "gene", + "text": "Before this date , the drug directly inhibits fetal weight gain , whereas the sensitivity of the placenta is only transient at day 16 resulting in maximum weight decrease of this organ 24 h later .", + "entities": [] + }, + { + "id": "6095", + "type": "gene", + "text": "The order of the helicase motif and the nsP3 homology region in the RUB genome is reversed with respect to the alphavirus genome indicating that a genetic rearrangement has occurred during the evolution of these viruses .", + "entities": [ + "helicase motif", + "nsP3 homology region" + ] + }, + { + "id": "6096", + "type": "gene", + "text": "Although both transcripts share the first nine exons , exon 10 of ZIS - 2 is lacking in ZIS - 1 , and instead , exon 11 ( 10th exon ) of ZIS - 1 is larger in size , leading to the longer 3 ' - UTR .", + "entities": [ + "ZIS - 2", + "ZIS - 1", + "ZIS - 1" + ] + }, + { + "id": "6097", + "type": "gene", + "text": "Comparisons of the four operon control regions studied indicate that the NarL heptamers are arranged with diverse orientations and spacing .", + "entities": [ + "NarL heptamers" + ] + }, + { + "id": "6098", + "type": "gene", + "text": "SETTING - - Women , Infants , and Children clinics in Minneapolis , Minn .", + "entities": [] + }, + { + "id": "6099", + "type": "gene", + "text": "Serum - ferritin in diagnosis of haemochromatosis .", + "entities": [ + "ferritin" + ] + }, + { + "id": "6100", + "type": "gene", + "text": "Endocytosis and lysosomal targeting of epidermal growth factor receptors are mediated by distinct sequences independent of the tyrosine kinase domain .", + "entities": [ + "epidermal growth factor receptors", + "tyrosine kinase domain" + ] + }, + { + "id": "6101", + "type": "gene", + "text": "What young people think and do when the option for cystic fibrosis carrier testing is available .", + "entities": [] + }, + { + "id": "6102", + "type": "gene", + "text": "The POEMS syndrome ( Polyneuropathy , Organomegaly , Endocrinopathy , Monoclonal component , Skin ) .", + "entities": [] + }, + { + "id": "6103", + "type": "gene", + "text": "In patients with myalgia , Raynaud ' s syndrome , skin vasculitis and vascular diseases WFAg concentrations were higher than in patients without them .", + "entities": [ + "WFAg" + ] + }, + { + "id": "6104", + "type": "gene", + "text": "For symptomatic relief and inhibition of the growth of the metastases interferon - a and somatostatin analogues can be employed .", + "entities": [ + "interferon - a", + "somatostatin" + ] + }, + { + "id": "6105", + "type": "gene", + "text": "A total of 112 patients received anistreplase and 119 received heparin within a mean period of 188 + / - 62 min following the onset of symptoms .", + "entities": [] + }, + { + "id": "6106", + "type": "gene", + "text": "Air lead was not a significant explanatory variable .", + "entities": [] + }, + { + "id": "6107", + "type": "gene", + "text": "One of these genes , REC114 , is described here , and the data confirm that REC114 is a meiosis - specific recombination gene with no detectable function in mitosis .", + "entities": [ + "REC114", + "REC114" + ] + }, + { + "id": "6108", + "type": "gene", + "text": "CMV hyperimmunoglobulin treatment ( Cytotect , Biotest ) was started ( 2 ml / kg bw on day 1 and 3 , and 1 ml / kg on days 5 , 7 and 9 ) , which led to the eradication of the residual infiltrate and CMV - DNA in the myocardium .", + "entities": [ + "hyperimmunoglobulin" + ] + }, + { + "id": "6109", + "type": "gene", + "text": "OBJECTIVE : This meta - analysis of 67 controlled trials was performed to quantify the cholesterol - lowering effect of major dietary fibers .", + "entities": [] + }, + { + "id": "6110", + "type": "gene", + "text": "The Drosophila clathrin heavy chain gene : clathrin function is essential in a multicellular organism .", + "entities": [ + "clathrin heavy chain", + "clathrin" + ] + }, + { + "id": "6111", + "type": "gene", + "text": "The RNA aptamer contains three stems separated by a pair of two - base bulges , and adopts an unanticipated fold in which both junctional sites are anchored through base triple formation .", + "entities": [] + }, + { + "id": "6112", + "type": "gene", + "text": "Neither is it a major cause of rehydration - induced renal Na retention .", + "entities": [] + }, + { + "id": "6113", + "type": "gene", + "text": "Microdetermination of adrenocortical steroids by double isotope method .", + "entities": [] + }, + { + "id": "6114", + "type": "gene", + "text": "As an extension of our structural characterization of the exon - intron organization of the mouse Pkr gene , we now have isolated and characterized the mouse Pkr promoter region required for IFN - inducible transcription .", + "entities": [ + "mouse Pkr gene", + "mouse Pkr promoter region", + "IFN" + ] + }, + { + "id": "6115", + "type": "gene", + "text": "Corticostriatal and corticosubthalamic input zones from the presupplementary motor area in the macaque monkey : comparison with the input zones from the supplementary motor area .", + "entities": [] + }, + { + "id": "6116", + "type": "gene", + "text": "Non - poliomyelitis AFP rate had increased from 0 . 9 in 1997 to 2 . 8 in 1998 .", + "entities": [] + }, + { + "id": "6117", + "type": "gene", + "text": "Resistance training shifts the power curve in a positive direction when the measurements are determined with absolute loads , but the increased power may not be transferred to an absolute performance task like the SSP .", + "entities": [] + }, + { + "id": "6118", + "type": "gene", + "text": "This suggested that baboon liver class I ADH is of the same ancestral lineage as the human ADH - beta .", + "entities": [ + "baboon liver class I ADH", + "human ADH - beta" + ] + }, + { + "id": "6119", + "type": "gene", + "text": "The results of the ISIS - 2 trial and the data from the Antiplatelet Trialists ' Collaboration indicated that aspirin is mandatory in patients with acute myocardial infarction and for secondary prevention .", + "entities": [] + }, + { + "id": "6120", + "type": "gene", + "text": "The mammalian phosphoinositide 3 - kinases ( PI3Ks ) p110alpha , beta , and delta form heterodimers with Src homology 2 ( SH2 ) domain - containing adaptors such as p85alpha or p55 ( PIK ) .", + "entities": [ + "mammalian phosphoinositide 3 - kinases", + "PI3Ks", + "p110alpha , beta , and delta", + "Src homology 2", + "SH2", + "p85alpha", + "p55", + "PIK" + ] + }, + { + "id": "6121", + "type": "gene", + "text": "DNase I and 1 , 10 - phenanthroline - copper footprinting of MURA - Mu1 TIR complexes indicate that MURA binds to a conserved approximately 32 - bp region in the TIR of Mu1 .", + "entities": [ + "DNase I", + "MURA", + "Mu1", + "MURA", + "Mu1" + ] + }, + { + "id": "6122", + "type": "gene", + "text": "There have been five problems ( extravasation 2 , suspected sepsis 1 , and hematoma 2 ) during a total of 2 , 927 days of exposure .", + "entities": [] + }, + { + "id": "6123", + "type": "gene", + "text": "The findings suggest that ERP effects of distinct memory processes are differentially influenced by the encoding instructions .", + "entities": [] + }, + { + "id": "6124", + "type": "gene", + "text": "Update : diphtheria epidemic in the newly independent states of the former USSR , January 1995 - March 1996 .", + "entities": [] + }, + { + "id": "6125", + "type": "gene", + "text": "Mutation of the P450BM - 3 Barbie box significantly increased the expression of both P450BM - 3 and Bm3P1 ( another small gene located upstream of the P450BM - 3 gene that encodes a second putative regulatory protein ) in response to pentobarbital induction but left the basal levels unaffected .", + "entities": [ + "P450BM - 3 Barbie box", + "P450BM - 3", + "Bm3P1", + "P450BM - 3 gene" + ] + }, + { + "id": "6126", + "type": "gene", + "text": "Apropos of a case", + "entities": [] + }, + { + "id": "6127", + "type": "gene", + "text": "A cDNA clone encoding C2H2 - type zinc finger protein , SCOF - 1 , was isolated from soybean .", + "entities": [ + "C2H2 - type zinc finger protein", + "SCOF - 1" + ] + }, + { + "id": "6128", + "type": "gene", + "text": "Connector enhancer of KSR ( CNK ) is a multidomain protein required for RAS signaling .", + "entities": [ + "Connector enhancer of KSR", + "CNK", + "RAS" + ] + }, + { + "id": "6129", + "type": "gene", + "text": "Reactive lymphoid hyperplasia was found in 15 cases , 2 cases had angiofollicular lymphoid hyperplasia or Castleman ' s disease , atypical lymphoid hyperplasia suggestive of malignant lymphoma was observed in 3 cases , and malignant lymphoma was diagnosed in the remaining 4 cases .", + "entities": [] + }, + { + "id": "6130", + "type": "gene", + "text": "This survey included 3000 randomly selected Norwegians above 18 years of age who received the European Organization for Research and Treatment of Cancer Core Quality of Life Questionnaire ( EORTC QLQ - C30 ( + 3 ) by mail .", + "entities": [] + }, + { + "id": "6131", + "type": "gene", + "text": "The interferon ( IFN ) - induced double - stranded RNA ( dsRNA ) - activated Ser / Thr protein kinase ( PKR ) plays a role in the antiviral and antiproliferative effects of IFN .", + "entities": [ + "interferon", + "IFN", + "double - stranded RNA ( dsRNA ) - activated Ser / Thr protein kinase", + "PKR", + "IFN" + ] + }, + { + "id": "6132", + "type": "gene", + "text": "Antithrombin III in hip surgery", + "entities": [ + "Antithrombin III" + ] + }, + { + "id": "6133", + "type": "gene", + "text": "A further analysis has been performed using the series of maximum intensity for fixed duration ( 1 , 3 , 6 , 12 , 24 hrs ) and annual daily maxima .", + "entities": [] + }, + { + "id": "6134", + "type": "gene", + "text": "The use of primary GE cells thus provides a convenient in vitro system for further study of the endocrine , paracrine , and autocrine factors regulating endometrial gene expression during pregnancy .", + "entities": [] + }, + { + "id": "6135", + "type": "gene", + "text": "M . leprae OxyR was overproduced and purified , and its binding to the oxyR - ahpC intergenic region of M . leprae was demonstrated .", + "entities": [ + "M . leprae OxyR", + "oxyR", + "ahpC" + ] + }, + { + "id": "6136", + "type": "gene", + "text": "The N3 wave of the SSEP ' s , which has been found to correlate best with neurological recovery , returned to 65 % + / - 48 % of the preischemia amplitude in the insulin - treated animals , compared to 40 % + / - 34 % in the fasted group and 26 % + / - 24 % in the control animals .", + "entities": [ + "insulin" + ] + }, + { + "id": "6137", + "type": "gene", + "text": "It seems that the way in which drugs modify a patient ' s serum chemistry may be used to assess the efficacy with which they control the inflammatory process .", + "entities": [] + }, + { + "id": "6138", + "type": "gene", + "text": "The duration of diabetes mellitus in these patients was from 5 months to 6 years , and in all patients this was the first myocardial infarction .", + "entities": [] + }, + { + "id": "6139", + "type": "gene", + "text": "To assess the effects of alveolar hypoxia and angiotensin II infusion on distribution of blood flow to the lung we performed perfusion lung scans on anesthetized mechanically ventilated lambs .", + "entities": [ + "angiotensin II" + ] + }, + { + "id": "6140", + "type": "gene", + "text": "In contrast , tobacco GS - 2 is composed of subunits of identical size in all organs examined .", + "entities": [ + "tobacco GS - 2" + ] + }, + { + "id": "6141", + "type": "gene", + "text": "The described results show that DTD is fast , simple , and easy to automate ; requires only a small amount of sample ( approximately 50 mg ) ; and affords quantitative information about the main groups of compounds present in cheeses .", + "entities": [] + }, + { + "id": "6142", + "type": "gene", + "text": "The FCMS conditions were as follows : 2 kW maximum electrical power consumption , 800 V maximum capacitor voltage , 720 microseconds pulsewidth ( 180 microseconds rise time ) , and 5 - 30 Hz frequency .", + "entities": [] + }, + { + "id": "6143", + "type": "gene", + "text": "RESULTS : The subjects in the augmented feedback group significantly reduced their peak vertical ground reaction force in both post - test conditions ( 2 - minute post - test reduction , 0 . 85 + / - 0 . 62 ; 1 - week post - test reduction , 0 . 74 + / - 0 . 58 ) as compared to the sensory , control I , and control II feedback groups .", + "entities": [] + }, + { + "id": "6144", + "type": "gene", + "text": "These results suggest that HAPE - S - S are prone to irregular nocturnal breathing patterns at high altitude , which is associated with the development of AMS , but it was not possible to determine whether these abnormal breathing patterns are a cause or an effect of AMS .", + "entities": [] + }, + { + "id": "6145", + "type": "gene", + "text": "Optical CD , and spectral and activity analyses were used to examine reactivity of HO isozymes with NO species produced by NO donors .", + "entities": [ + "HO isozymes" + ] + }, + { + "id": "6146", + "type": "gene", + "text": "Effects of ketamine on the circulatory functions and body tissue oxygenation in dogs under normal and hypovolemic conditions .", + "entities": [] + }, + { + "id": "6147", + "type": "gene", + "text": "One of the conserved RNA subdomains , designated P3 , has previously been shown to be required for nucleolar localization .", + "entities": [ + "P3" + ] + }, + { + "id": "6148", + "type": "gene", + "text": "Selective activation of adrenaline secretion by the rat adrenal in neuroglycopenia detected via microdialysis", + "entities": [] + }, + { + "id": "6149", + "type": "gene", + "text": "PRDII - BF1 - derived cDNAs did not result in stimulation of either basal or tat - induced activated gene expression .", + "entities": [ + "PRDII - BF1 - derived cDNAs", + "tat" + ] + }, + { + "id": "6150", + "type": "gene", + "text": "In part as a result of its inability to sustain radiative loses , the BB resonator has extremely low RF power requirements .", + "entities": [] + }, + { + "id": "6151", + "type": "gene", + "text": "The general recombination at a polarizing voltage of 300 V is less than 2 % for dose - rates up to about 100 mGy min - 1 .", + "entities": [] + }, + { + "id": "6152", + "type": "gene", + "text": "CONCLUSIONS : The methodology of LHR measurement significantly influences the clinical contribution of Tl - 201 lung uptake evaluation .", + "entities": [] + }, + { + "id": "6153", + "type": "gene", + "text": "The plexiform neurofibroma and multiple localized neurofibromas are characteristic of NF1 .", + "entities": [ + "NF1" + ] + }, + { + "id": "6154", + "type": "gene", + "text": "Both the Cmax and AUC values were almost doubled with doubling the dose .", + "entities": [] + }, + { + "id": "6155", + "type": "gene", + "text": "This study shows that C / EBPbeta is the predominant C / EBP isoform found in activated stellate cells and that increased C / EBPbeta protein and C / EBPbeta binding to a proximal C / EBP binding site in the promoter mediates the activating effect of acetaldehyde .", + "entities": [ + "C / EBPbeta", + "C / EBP isoform", + "C / EBPbeta protein", + "C / EBPbeta", + "C / EBP binding site" + ] + }, + { + "id": "6156", + "type": "gene", + "text": "Interpersonal style differences among drug abusers were explored using Ryan ' s ( 1977 ) typological system of FIRO - B interpretation .", + "entities": [] + }, + { + "id": "6157", + "type": "gene", + "text": "Because the high - density lipoprotein receptor ( HDL - R ) is a key element in cholesterol homeostasis and a potential therapeutic target for hypercholesterolemic drugs , an understanding of HDL - R regulation is essential .", + "entities": [ + "high - density lipoprotein receptor", + "HDL - R", + "HDL - R" + ] + }, + { + "id": "6158", + "type": "gene", + "text": "ST elevation occurs in 5 patients ( 55 . 5 % ) of subgroup A and in no patient of the subgroup B .", + "entities": [] + }, + { + "id": "6159", + "type": "gene", + "text": "The active derivatives of the present series were also tested for their analgesic activity against aconitine - induced writhing in albino mice and ulcerogenic activity in albino rats .", + "entities": [] + }, + { + "id": "6160", + "type": "gene", + "text": "Assay of serum immunoreactive trypsin in dried blood spots and the early detection of cystic fibrosis .", + "entities": [ + "serum immunoreactive trypsin" + ] + }, + { + "id": "6161", + "type": "gene", + "text": "There was significant correlation of LVM / M2 and PWVn for pre - AVR and post AVR studies .", + "entities": [] + }, + { + "id": "6162", + "type": "gene", + "text": "All subjects were submitted to ECG and arterial blood pressure determination and were assayed for TSH , thyroid hormone , PRL , glucose , creatinine , nitrogen , glutamine transaminase , cholesterol and triglycerides plasma levels before therapy ( T0 ) , after 30 treatment days ( T30 ) and after a 15 days washout ( T45 ) .", + "entities": [ + "TSH", + "PRL", + "glutamine transaminase" + ] + }, + { + "id": "6163", + "type": "gene", + "text": "The results showed that the sensitivity of the 3 given guinea pig strains was comparable .", + "entities": [] + }, + { + "id": "6164", + "type": "gene", + "text": "Among the LE6 deletions , only one had a reduced transformation efficiency , while seven transformed cells at least as efficiently as wild - type LE6 .", + "entities": [ + "LE6", + "wild - type LE6" + ] + }, + { + "id": "6165", + "type": "gene", + "text": "Site - directed mutagenesis of CAR revealed that CAR residues Leu73 and Lys121 and / or Lys123 are critical contact residues , with Tyr80 and Tyr83 being peripherally involved in the binding interaction with the Ad5 , Ad9 , Ad12 , and Ad41L fiber knobs .", + "entities": [ + "CAR", + "CAR", + "Ad5 , Ad9 , Ad12 , and Ad41L fiber knobs" + ] + }, + { + "id": "6166", + "type": "gene", + "text": "In addition , the ketamine - treated rats had more neurons and glial cells surrounding the ventricles .", + "entities": [] + }, + { + "id": "6167", + "type": "gene", + "text": "The glomerular filtration rate did not change but lithium clearance fell by 30 % .", + "entities": [] + }, + { + "id": "6168", + "type": "gene", + "text": "Disruption of ARF2 causes no detectable phenotype .", + "entities": [ + "ARF2" + ] + }, + { + "id": "6169", + "type": "gene", + "text": "Similar data were also obtained when either dominant negative EGFR - CD533 or dominant negative Ras N17 were used to block MAPK activation .", + "entities": [ + "EGFR", + "CD533", + "dominant negative Ras N17", + "MAPK" + ] + }, + { + "id": "6170", + "type": "gene", + "text": "Proteolysis of Mbp1 and Swi4 DNA - protein complexes has revealed the extent of these sequences , and C - terminally extended molecules with substantially enhanced DNA binding activity compared to the core domains alone have been produced .", + "entities": [ + "Mbp1", + "Swi4 DNA - protein complexes" + ] + }, + { + "id": "6171", + "type": "gene", + "text": "This suggests roles for both the CE1 and CE2 elements in regulating Hoxb1 gene expression during development .", + "entities": [ + "Hoxb1 gene" + ] + }, + { + "id": "6172", + "type": "gene", + "text": "The conservation of both the G - box and H - box in different CHS promoters emphasizes their importance as regulatory motifs .", + "entities": [ + "CHS promoters" + ] + }, + { + "id": "6173", + "type": "gene", + "text": "Notably , SRF has been found to be a key regulator of members of a class of cellular response genes termed immediate - early genes ( IEGs ) , many of which are believed to be involved in regulating cell growth and differentiation .", + "entities": [ + "SRF", + "immediate - early genes", + "IEGs" + ] + }, + { + "id": "6174", + "type": "gene", + "text": "One group of six cDNA clones was derived from a 2 . 9 - kilobase early transcript encoded by the IR2 repeat element and showed restriction site polymorphism for the enzyme SmaI .", + "entities": [ + "enzyme SmaI" + ] + }, + { + "id": "6175", + "type": "gene", + "text": "Oxygen profiles calculated for the Krogh model with excentric diffusion were similar to those derived for the two models of concentric diffusion .", + "entities": [] + }, + { + "id": "6176", + "type": "gene", + "text": "Liver injuries", + "entities": [] + }, + { + "id": "6177", + "type": "gene", + "text": "Zinc fingers ( Zf ) are a common structural motif found in many nucleic acid - binding proteins .", + "entities": [] + }, + { + "id": "6178", + "type": "gene", + "text": "A new UASH consensus sequence derived from this mutational analysis closely matches a consensus Abf1 binding site .", + "entities": [ + "Abf1 binding site" + ] + }, + { + "id": "6179", + "type": "gene", + "text": "Unlike p59v - rel , which is a nuclear protein in CEF , indirect immunofluorescence showed that p68c - rel in JD214c - rel infected CEF is located exclusively in the cytoplasm of these cells , even though the sequence of p68c - rel showed that it contains a nuclear localizing sequence identical to the one previously identified in p59v - rel .", + "entities": [ + "p59v", + "rel", + "p68c", + "rel", + "p68c", + "rel", + "p59v", + "rel" + ] + }, + { + "id": "6180", + "type": "gene", + "text": "Either 20 mg mitomycin / 20 ml distilled water or 40 mg / 40 ml distilled water was locally instilled into the bladder with a catheter after emptying it and was left for about 25 - l20 min .", + "entities": [] + }, + { + "id": "6181", + "type": "gene", + "text": "Role of secondary structure in discrimination between constitutive and inducible activators .", + "entities": [] + }, + { + "id": "6182", + "type": "gene", + "text": "While fusion to the N - terminus required a linker to become surface accessible , both fusion to the N - terminus and to the C - terminus was compatible with particle assembly and preserved the native antigenicity and immunogenicity of HBcAg .", + "entities": [ + "HBcAg" + ] + }, + { + "id": "6183", + "type": "gene", + "text": "The origins of reflected light changes associated with neuronal activity ( optical signals ) were investigated in rat somatosensory cortex with optical imaging , microspectrophotometry , and laser - Doppler flowmetry , and dynamic changes in local hemoglobin concentration and oxygenation were focused on .", + "entities": [ + "hemoglobin" + ] + }, + { + "id": "6184", + "type": "gene", + "text": "The effect of L - methionine supplementation on the utilization of a soy protein isolate ( SPI ) was evaluated by short - term nitrogen balance studies in young women .", + "entities": [] + }, + { + "id": "6185", + "type": "gene", + "text": "The interleukin 2 receptor alpha - chain ( IL - 2R alpha ) gene is rapidly and potently induced in T cells in response to mitogenic stimuli .", + "entities": [ + "interleukin 2 receptor alpha - chain", + "IL - 2R alpha" + ] + }, + { + "id": "6186", + "type": "gene", + "text": "These risk factors can be divided into 2 groups : local vessel wall - related factors , and local ( focal action ) systemic factors .", + "entities": [] + }, + { + "id": "6187", + "type": "gene", + "text": "Copyright 2000 Academic Press .", + "entities": [] + }, + { + "id": "6188", + "type": "gene", + "text": "Our results support a model where both E2F - and CDE - mediated repression , acting at different stages in the cell cycle , are dependent on promoter - specific CHR elements .", + "entities": [ + "E2F" + ] + }, + { + "id": "6189", + "type": "gene", + "text": "We produced transgenic plants expressing the antisense Arabidopsis HD ( AtHD1 ) gene .", + "entities": [ + "antisense Arabidopsis HD", + "AtHD1" + ] + }, + { + "id": "6190", + "type": "gene", + "text": "Male contraception : ideas for the future .", + "entities": [] + }, + { + "id": "6191", + "type": "gene", + "text": "Growth factor allows effective dose - intensive regimen in advanced breast cancer patients .", + "entities": [] + }, + { + "id": "6192", + "type": "gene", + "text": "Advances in the management of gynecologic cancer - - radiation therapy .", + "entities": [] + }, + { + "id": "6193", + "type": "gene", + "text": "These data support the idea that the repression activity of NRSF / REST depends upon the species of promoter to which it is linked and upon the proteins that bind to those promoters .", + "entities": [ + "NRSF", + "REST" + ] + }, + { + "id": "6194", + "type": "gene", + "text": "The Cut9 subunit is likely to be a target for regulating APC / cyclosome function through protein - protein interactions and phosphorylation .", + "entities": [ + "Cut9 subunit", + "APC / cyclosome" + ] + }, + { + "id": "6195", + "type": "gene", + "text": "To address the biological effect of specific isoform expression , NIH3T3 cells were transfected with a eukaryotic expression vector containing cDNA for FGF8a , FGF8b , or FGF8e .", + "entities": [ + "FGF8a", + "FGF8b", + "FGF8e" + ] + }, + { + "id": "6196", + "type": "gene", + "text": "Editorial : Low - dose heparin and the prevention of venous thromboembolic disease .", + "entities": [] + }, + { + "id": "6197", + "type": "gene", + "text": "Time to progression was 6 months ( 5 - 7 months ) with a median survival from registration of 9 . 6 months ( 95 % CI 8 - 12 months ) .", + "entities": [] + }, + { + "id": "6198", + "type": "gene", + "text": "Replacing the aspartic acid with a lysine but not with an alanine or valine residue allowed formation of disulfide - linked dimers .", + "entities": [] + }, + { + "id": "6199", + "type": "gene", + "text": "All members are also capable of activating in vivo transcription from promoters that contain a C / EBP - binding site .", + "entities": [ + "C / EBP - binding site" + ] + }, + { + "id": "6200", + "type": "gene", + "text": "Critical study", + "entities": [] + }, + { + "id": "6201", + "type": "gene", + "text": "The N terminus of beta ( 95 kDa ) corresponds to alpha with the integrase domain attached to the C terminus ( 32 kDa ) .", + "entities": [ + "integrase domain" + ] + }, + { + "id": "6202", + "type": "gene", + "text": "Analysis of ace2Delta cells reveals that Ace2p is required for cell separation but not for polarized growth .", + "entities": [ + "Ace2p" + ] + }, + { + "id": "6203", + "type": "gene", + "text": "In the meantime , one has succeeded to establish the deammonification processes in a continuous flow moving - bed pilot plant .", + "entities": [] + }, + { + "id": "6204", + "type": "gene", + "text": "Recognition of emphysema was poor when radiographs of inadequate quality were included ( anteroposterior films or films from patients with acute or chronic lung disease ) .", + "entities": [] + }, + { + "id": "6205", + "type": "gene", + "text": "Private hospital accreditation .", + "entities": [] + }, + { + "id": "6206", + "type": "gene", + "text": "Another element necessary for augmenting the amplitude of the oscillation lies between - 178 and - 264 .", + "entities": [] + }, + { + "id": "6207", + "type": "gene", + "text": "When the coding segments , including both framework and complementarity - determining regions , of these genes and the murine probe sequences are compared by metric analysis , it is apparent that the caiman genes are only slightly more related to each other than to the mammalian sequence , consistent with significant preservation of nucleotide sequence over an extended period of phylogenetic time .", + "entities": [] + }, + { + "id": "6208", + "type": "gene", + "text": "100 years of dentistry at the Friedrich Schiller University in Jena", + "entities": [] + }, + { + "id": "6209", + "type": "gene", + "text": "Ang II - induced fibronectin mRNA was not affected by PKC inhibitors or PKC depletion , whereas specific inhibition of EGF - R function by a dominant negative EGF - R mutant and tyrphostin AG1478 abolished induction of fibronectin mRNA .", + "entities": [ + "Ang II", + "fibronectin", + "PKC", + "PKC", + "EGF - R", + "dominant negative EGF - R mutant", + "fibronectin mRNA" + ] + }, + { + "id": "6210", + "type": "gene", + "text": "Positive CRP test were seen .", + "entities": [ + "CRP" + ] + }, + { + "id": "6211", + "type": "gene", + "text": "Setting takes place through complex formation of ( NH4Mg PO4 . 6H2O ) n , excess reactants , and water .", + "entities": [] + }, + { + "id": "6212", + "type": "gene", + "text": "There has been similar improvement in treating ampullary and periampullary cancer , gallbladder cancer , or extrahepatic bile duct cancer .", + "entities": [] + }, + { + "id": "6213", + "type": "gene", + "text": "The relatively high level transcription from this gene shows that the polymorphic chromosome ends of P . falciparum , which have been proposed to be transcriptionally silent , can be active expression sites for var genes .", + "entities": [ + "var genes" + ] + }, + { + "id": "6214", + "type": "gene", + "text": "Effects of chronic metaraminol treatment on the sympathetic activity of intact and adrenal demedullated rats kept in warm or cold environments .", + "entities": [] + }, + { + "id": "6215", + "type": "gene", + "text": "This inhibition can be overcome by mutating either the exon ' s 5 ' or 3 ' splice site to make it correspond more closely to the relevant consensus sequence .", + "entities": [] + }, + { + "id": "6216", + "type": "gene", + "text": "The modalities for using reference values for individual subjects as well as for groups are then discussed and the main points of research which must be faced in the near future regarding reference values are highlighted .", + "entities": [] + }, + { + "id": "6217", + "type": "gene", + "text": "Stoichiometric phosphorylation of human p53 at Ser315 stimulates p53 - dependent transcription .", + "entities": [ + "human p53", + "p53" + ] + }, + { + "id": "6218", + "type": "gene", + "text": "p53 protein activity as a transcription factor can be activated in vivo by antibodies that target its C - terminal negative regulatory domain suggesting that cellular enzymes that target this domain may play a role in stimulating p53 - dependent gene expression .", + "entities": [ + "p53 protein", + "p53" + ] + }, + { + "id": "6219", + "type": "gene", + "text": "Nucleotide sequences of the clones revealed that one clone , cap3 , contained an open reading frame ( ORF ) that would code for a 26 - amino acid , cysteine - rich peptide with significant homology to Neurospora crassa copper metallothionein .", + "entities": [ + "cap3", + "Neurospora crassa copper metallothionein" + ] + }, + { + "id": "6220", + "type": "gene", + "text": "Human ULK1 , a novel serine / threonine kinase related to UNC - 51 kinase of Caenorhabditis elegans : cDNA cloning , expression , and chromosomal assignment .", + "entities": [ + "Human ULK1", + "serine / threonine kinase", + "UNC - 51 kinase" + ] + }, + { + "id": "6221", + "type": "gene", + "text": "The Y - type structural motif is also conserved among a number of divergent BiP mRNAs .", + "entities": [ + "BiP mRNAs" + ] + }, + { + "id": "6222", + "type": "gene", + "text": "However , in a new experiment in which the deletion task was presented as a puppet game , and with pretraining and selection on vowel deletion , a significantly higher level of success was achieved by the children working with the CVCC material .", + "entities": [] + }, + { + "id": "6223", + "type": "gene", + "text": "In one of these tumors the observed rearrangement was not due to the insertion of an intact MoMuLV provirus .", + "entities": [] + }, + { + "id": "6224", + "type": "gene", + "text": "Less antibacterial activity was shown toward the Gram - negative bacilli , i . e . , Pseudomonas , Klebsiella - Enterobacter , Shigella , Escherichia coli , Serratia marcescens and Proteus .", + "entities": [] + }, + { + "id": "6225", + "type": "gene", + "text": "Mapping features of HIV - 1 integrase near selected sites on viral and target DNA molecules in an active enzyme - DNA complex by photo - cross - linking .", + "entities": [ + "HIV - 1 integrase" + ] + }, + { + "id": "6226", + "type": "gene", + "text": "The scores are dependent in part on the reliability of faculty evaluations .", + "entities": [] + }, + { + "id": "6227", + "type": "gene", + "text": "Both variants display the seven - transmembrane topology that is typical for G protein - coupled receptors .", + "entities": [ + "G protein - coupled receptors" + ] + }, + { + "id": "6228", + "type": "gene", + "text": "However , the mouse has previously been shown to possess only three forms of ADH .", + "entities": [ + "ADH" + ] + }, + { + "id": "6229", + "type": "gene", + "text": "Electrophoretic characteriaztion of virus - induced interferon of the blood and urine in rabbits", + "entities": [ + "interferon" + ] + }, + { + "id": "6230", + "type": "gene", + "text": "One was allowed fresh drinking water ad libitum whilst the other received Aludrox in their drinking water .", + "entities": [] + }, + { + "id": "6231", + "type": "gene", + "text": "Nuclear spin of 249Bk from the hyperfine structure in its emission spectrum .", + "entities": [] + }, + { + "id": "6232", + "type": "gene", + "text": "A newly developed broad - spectrum fluoroquinolone , levofloxacin ( LVFX , DR - 3355 ) , was evaluated in vitro and in vivo in comparison with ciprofloxacin ( CPFX ) , ofloxacin ( OFLX ) and norfloxacin ( NFLX ) .", + "entities": [] + }, + { + "id": "6233", + "type": "gene", + "text": "The tissue - specific expression of DP family members suggests that the combination of DP / E2F heterodimers that constitute DRTF1 / E2F is influenced by the phenotype of the cell .", + "entities": [ + "DP family members", + "DP", + "E2F", + "DRTF1", + "E2F" + ] + }, + { + "id": "6234", + "type": "gene", + "text": "To determine whether interaction of arsenite with the hormone - binding domain results in receptor activation , COS - 1 cells were transiently cotransfected with the chimeric receptors GAL - ER , which contains the hormone - binding domain of ERalpha and the DNA - binding domain of the transcription factor GAL4 , and a GAL4 - responsive CAT reporter gene .", + "entities": [ + "chimeric receptors GAL - ER", + "ERalpha", + "GAL4", + "GAL4", + "CAT reporter gene" + ] + }, + { + "id": "6235", + "type": "gene", + "text": "Primary invasive Haemophilus influenzae type b disease : a population - based assessment of risk factors .", + "entities": [] + }, + { + "id": "6236", + "type": "gene", + "text": "Serum IgE levels in Tauranga children .", + "entities": [ + "Serum IgE" + ] + }, + { + "id": "6237", + "type": "gene", + "text": "Tracheal transsection combined with hilar ligation ( TL & PL ) effected a reduction of 19 . 9 % ( n . s . ) .", + "entities": [] + }, + { + "id": "6238", + "type": "gene", + "text": "Fifty - six semen samples were included in this study ; 18 were subnormal ( G1 ) and 38 were normal ( G2 ) based on World Health Organization criteria , except for morphology , which was evaluated according to strict criteria .", + "entities": [] + }, + { + "id": "6239", + "type": "gene", + "text": "The assay exhibits a dynamic range of 0 . 1 - 100 micrograms l - 1 using a monoclonal antibody or alternatively 10 micrograms l - 1 to 10 mg l - 1 using commercially available antiserum .", + "entities": [] + }, + { + "id": "6240", + "type": "gene", + "text": "Thus , the presence of the Cln2 PEST domain was sufficient to destabilize a heterologous protein .", + "entities": [ + "Cln2 PEST domain" + ] + }, + { + "id": "6241", + "type": "gene", + "text": "Growth curves indicated that proliferation of clone CA9 in the presence of 10 % serum was reduced by 60 % compared with clone ME10 .", + "entities": [] + }, + { + "id": "6242", + "type": "gene", + "text": "In men with BMI < 30 , the OR was 1 . 83 for postprandial TG ( P = . 041 ) and 2 . 77 for postprandial RP ( P = . 032 ) in models that included fasting TG , LDL - C , and hypertension .", + "entities": [ + "LDL - C" + ] + }, + { + "id": "6243", + "type": "gene", + "text": "OBJECTIVES : 1 ) to determine serum ACE activity in patients with COPD treated with and without continuous ambulatory oxygen therapy ( CAOT ) ; 2 ) to verify whether there is a correlation between ACE and any hematological , spirometric or gasometric parameter .", + "entities": [ + "serum ACE", + "ACE" + ] + }, + { + "id": "6244", + "type": "gene", + "text": "A 16 - year follow - up study of 69 paraplegics with complete lesions from T1 - L3 is presented .", + "entities": [] + }, + { + "id": "6245", + "type": "gene", + "text": "The case described is that of a 72 - year - old man with ochronosis who suffered a hyperextension injury to his spine in a fall , resulting in a fracture through an ankylosed L2 - L3 disk space .", + "entities": [] + }, + { + "id": "6246", + "type": "gene", + "text": "We conclude that transcription activation by LEF - 1 in vitro is a chromatin - dependent process that requires a functional trans - activation domain in addition to the HMG domain .", + "entities": [ + "LEF - 1", + "HMG domain" + ] + }, + { + "id": "6247", + "type": "gene", + "text": "Whereas cDNA hybridization to genomic DNA blots indicated a small subfamily of G0S19 genes , simple patterns of bands indicated that most cDNAs , including G0S30 cDNA , corresponded to single - copy genes .", + "entities": [ + "G0S19 genes", + "G0S30 cDNA" + ] + }, + { + "id": "6248", + "type": "gene", + "text": "By directly interacting with both Arfs and tyrosine kinases involved in regulating cell growth and cytoskeletal organization , ASAP1 could coordinate membrane remodeling events with these processes .", + "entities": [ + "Arfs", + "tyrosine kinases", + "ASAP1" + ] + }, + { + "id": "6249", + "type": "gene", + "text": "We have investigated the role of NGF in regulating gene transcription in PC12 and INS - 1 cells , in order to define if there are NGF - regulated genes per se .", + "entities": [ + "NGF", + "NGF" + ] + }, + { + "id": "6250", + "type": "gene", + "text": "Recovery was characterized by rapid improvement such that all measured parameters normalized by 1 week , except for cross - sectional cardiac area which remained dilated up to 4 weeks ( 14 + / - 3 cm2 , p less than 0 . 05 versus control ) . ( ABSTRACT TRUNCATED AT 250 WORDS )", + "entities": [] + }, + { + "id": "6251", + "type": "gene", + "text": "Late complications of catheterisation for intravenous nutrition .", + "entities": [] + }, + { + "id": "6252", + "type": "gene", + "text": "Hyperthyroidism", + "entities": [] + }, + { + "id": "6253", + "type": "gene", + "text": "Mean ROI - A / B ratio was 49 . 6 + / - 1 . 7 % in the diabetic group , significantly lower than the 57 . 9 + / - 1 . 6 % at the nondiabetic group ( p less than 0 . 005 ) .", + "entities": [] + }, + { + "id": "6254", + "type": "gene", + "text": "Transcription factor recognition surface on the RNA polymerase alpha subunit is involved in contact with the DNA enhancer element .", + "entities": [ + "RNA polymerase alpha subunit" + ] + }, + { + "id": "6255", + "type": "gene", + "text": "The three - dimensional structure of RT shows that it is a strikingly asymmetric heterodimer consisting of two differently folded subunits ( molecular weights 66 kDa and 51 kDa ) with identical amino - terminal amino acid sequences ( residues 1 - 428 ) .", + "entities": [ + "RT" + ] + }, + { + "id": "6256", + "type": "gene", + "text": "No correlation between the age of the horses and the antibody level could be found .", + "entities": [] + }, + { + "id": "6257", + "type": "gene", + "text": "As shown previously , EBNA2 transactivates the promoters of the viral latent membrane proteins .", + "entities": [ + "EBNA2", + "viral latent membrane proteins" + ] + }, + { + "id": "6258", + "type": "gene", + "text": "We conclude that the gp54 structural gene is required for initiation or amplification of the splenic erythroblast hyperplasia which characterizes the preleukemic phase of Rauscher disease .", + "entities": [ + "gp54 structural gene" + ] + }, + { + "id": "6259", + "type": "gene", + "text": "In spite of much effort , no one has succeeded in isolating and characterizing the enzyme ( s ) responsible for synthesis of cellulose , the major cell wall polymer of plants .", + "entities": [] + }, + { + "id": "6260", + "type": "gene", + "text": "The present study investigated dose dependence and time course effects of the benzodiazepine ( BDZ ) partial inverse agonist , RO19 - 4603 ( 0 . 005 - 0 . 30 mg / kg ) alone , and in combination with the BDZ receptor antagonists flumazenil , ZK 93426 , and CGS 8216 ( 20 mg / kg ) in selectively bred alcohol - preferring ( P ) rats provided a two - bottle choice test between ethanol ( EtOH ) ( 10 % v / v ) , and a palatable saccharin ( 0 . 0125 % g / v ) solution .", + "entities": [ + "BDZ receptor" + ] + }, + { + "id": "6261", + "type": "gene", + "text": "Mitochondria - lytic action of warfarin in lymphocytes .", + "entities": [] + }, + { + "id": "6262", + "type": "gene", + "text": "We have cloned and sequenced a 3574 - bp Bacillus subtilis ( Bs ) DNA fragment located between the nrdA and citB genes at about 169 degrees on the chromosome .", + "entities": [ + "nrdA", + "citB genes" + ] + }, + { + "id": "6263", + "type": "gene", + "text": "Injection of double - stranded RNA into C . elegans results in embryonic lethality ; thus , the SF1 gene is essential not only in yeast but also in at least one metazoan .", + "entities": [ + "SF1 gene" + ] + }, + { + "id": "6264", + "type": "gene", + "text": "If we apply the finding of non - visualization of the GB at 4 h post injection as the criterion for the diagnosis of AC , the diagnostic accuracy was only 40 . 7 % ( 11 / 27 ) .", + "entities": [] + }, + { + "id": "6265", + "type": "gene", + "text": "Recently , we have reported the cloning of the germ cell - specific , nuclear orphan receptor germ cell nuclear factor ( GCNF ) / RTR .", + "entities": [ + "germ cell nuclear factor", + "GCNF", + "RTR" + ] + }, + { + "id": "6266", + "type": "gene", + "text": "Both quantitative and qualitative analysis of individual cytoarchitectonic peculiarities of Meynart ' s nucleus as well as of external part of dorsomedial nucleus of thalamus was performed in mentally normal individuals .", + "entities": [] + }, + { + "id": "6267", + "type": "gene", + "text": "Structure and regulation of a nuclear gene in Saccharomyces cerevisiae that specifies MRP13 , a protein of the small subunit of the mitochondrial ribosome .", + "entities": [ + "MRP13" + ] + }, + { + "id": "6268", + "type": "gene", + "text": "At the time of the 13 latest BPVs , age ranged from three days to 13 . 1 years ( mean 5 . 7 + / - SD 4 . 8 years ) .", + "entities": [] + }, + { + "id": "6269", + "type": "gene", + "text": "One is to act within the visceral endoderm to promote proper streak morphogenesis .", + "entities": [] + }, + { + "id": "6270", + "type": "gene", + "text": "One R - EST and one Pto - like sequence each mapped to two locations .", + "entities": [ + "Pto - like sequence" + ] + }, + { + "id": "6271", + "type": "gene", + "text": "An IgG monoclonal gammopathy was present in the serum of 4 patients and Bence - Joanes proteinuria was found in 1 patient .", + "entities": [ + "IgG" + ] + }, + { + "id": "6272", + "type": "gene", + "text": "Human GATA - 3 : a lineage - restricted transcription factor that regulates the expression of the T cell receptor alpha gene .", + "entities": [ + "Human GATA - 3", + "T cell receptor alpha gene" + ] + }, + { + "id": "6273", + "type": "gene", + "text": "We have previously shown that ARNO localizes to the plasma membrane in vivo and efficiently catalyzes ARF6 nucleotide exchange in vitro .", + "entities": [ + "ARNO", + "ARF6" + ] + }, + { + "id": "6274", + "type": "gene", + "text": "Comparison of frequencies of atrial fibrillation after coronary artery bypass grafting with and without the use of cardiopulmonary bypass .", + "entities": [] + }, + { + "id": "6275", + "type": "gene", + "text": "Cbf3 contains three proteins , Cbf3a , Cbf3b and Cbf3c .", + "entities": [ + "Cbf3", + "Cbf3a", + "Cbf3b", + "Cbf3c" + ] + }, + { + "id": "6276", + "type": "gene", + "text": "Lipoprotein lipase ( LPL ) , a key enzyme in normal lipoprotein metabolism , has a complex pattern of regulation and tissue - specific expression .", + "entities": [ + "Lipoprotein lipase", + "LPL" + ] + }, + { + "id": "6277", + "type": "gene", + "text": "Initial experience with a microprocessor controlled current based defibrillator .", + "entities": [] + }, + { + "id": "6278", + "type": "gene", + "text": "The incidence of HSV - 2 positive subjects ( HSV - 2 / HSV - 1 antibody ratio > or = 1 ) was low in the Jewish Israeli population , compared to other demographic areas .", + "entities": [ + "HSV - 2 / HSV - 1 antibody" + ] + }, + { + "id": "6279", + "type": "gene", + "text": "Wnt - 1 overexpression in mammary epithelial cells induced cyclin D1 mRNA and targeted overexpression of Wnt - 1 in the mammary gland of transgenic mice increased both ILK activity and cyclin D1 levels .", + "entities": [ + "Wnt - 1", + "cyclin D1 mRNA", + "Wnt - 1", + "ILK", + "cyclin D1" + ] + }, + { + "id": "6280", + "type": "gene", + "text": "Interestingly , the positions of these introns have been conserved in comparison with the genes of two other transglutaminase - like activities described in the literature , but the TGM1 gene is by far the smallest characterized to date because its introns are relatively smaller .", + "entities": [ + "TGM1 gene" + ] + }, + { + "id": "6281", + "type": "gene", + "text": "The newly devised DCT method yields reliable data in measuring TBF .", + "entities": [] + }, + { + "id": "6282", + "type": "gene", + "text": "We conclude that common upstream signals cause activation of Ras and TC21 , but activated TC21 controls cell growth via distinct Raf - independent downstream signaling pathways .", + "entities": [ + "Ras", + "TC21", + "TC21", + "Raf" + ] + }, + { + "id": "6283", + "type": "gene", + "text": "RESULTS : Of the patients with IS , 67 % had significantly greater values of directional preponderance on the OVAR test ( a measure of otolith system imbalance ) compared with control subjects .", + "entities": [] + }, + { + "id": "6284", + "type": "gene", + "text": "The murine facilitative glucose transporter isoform 3 ( Glut 3 ) is developmentally regulated and is predominantly expressed in neurons and trophoblasts .", + "entities": [ + "murine facilitative glucose transporter isoform 3", + "Glut 3" + ] + }, + { + "id": "6285", + "type": "gene", + "text": "With the increasing use of ACE inhibitors , the incidence of rare adverse effects such as potentially lethal pancreatitis is likely to increase .", + "entities": [ + "ACE" + ] + }, + { + "id": "6286", + "type": "gene", + "text": "These results suggest KCC3 is a new member of the KCC family that is under distinct regulation from KCC1 .", + "entities": [ + "KCC3", + "KCC family", + "KCC1" + ] + }, + { + "id": "6287", + "type": "gene", + "text": "OBJECTIVE : To determine the impact of the introduction of clarithromycin and azithromycin on the treatment and survival of patients with AIDS and disseminated Mycobacterium avium complex ( DMAC ) .", + "entities": [] + }, + { + "id": "6288", + "type": "gene", + "text": "Piroximone is a new phosphodiesterase III inhibitor that combines inotropic and vasodilator properties .", + "entities": [ + "phosphodiesterase III" + ] + }, + { + "id": "6289", + "type": "gene", + "text": "Feed intake and BW gains were decreased ( P < 0 . 05 ) by dietary treatments containing M .", + "entities": [] + }, + { + "id": "6290", + "type": "gene", + "text": "The aspirate from a parathyroid cyst was watery clear and contained high amount of parathyroid hormone .", + "entities": [ + "parathyroid hormone" + ] + }, + { + "id": "6291", + "type": "gene", + "text": "These transcripts have a unique 5 ' untranslated region and NH2 - terminal sequence and encode a predicted protein of 121 kD .", + "entities": [] + }, + { + "id": "6292", + "type": "gene", + "text": "This makes these compounds attractive as vehicles for these and other gases in - vivo and in - vitro .", + "entities": [] + }, + { + "id": "6293", + "type": "gene", + "text": "This paper gives an overview of the global pattern of casualties in earthquakes which occurred during the 30 - month period from 1 September 1993 to 29 February 1996 .", + "entities": [] + }, + { + "id": "6294", + "type": "gene", + "text": "Serotonin 5 - HT2 receptor binding on blood platelets as a state dependent marker in major affective disorder .", + "entities": [ + "Serotonin 5 - HT2 receptor" + ] + }, + { + "id": "6295", + "type": "gene", + "text": "There was no evident inciting agent of the disease .", + "entities": [] + }, + { + "id": "6296", + "type": "gene", + "text": "RNase MRP is a ribonucleoprotein endoribonuclease that has been shown to have roles in both mitochondrial DNA replication and nuclear 5 . 8S rRNA processing .", + "entities": [ + "RNase MRP", + "nuclear 5 . 8S rRNA" + ] + }, + { + "id": "6297", + "type": "gene", + "text": "We found that the gene segment containing the mu m poly ( A ) signals , along with 536 bp of downstream flanking sequence , acted as a transcription terminator in both myeloma cells and L cell fibroblasts .", + "entities": [] + }, + { + "id": "6298", + "type": "gene", + "text": "Our results indicate that serum BGP is a valuable measurement of bone metabolism .", + "entities": [ + "serum BGP" + ] + }, + { + "id": "6299", + "type": "gene", + "text": "For this , cDNAs containing the 60K , 87K , 110K and 170K protein coding sequences were each provided with an ATG start codon and the cDNA containing the 60K coding sequence with a TAA stop codon immediately downstream of the coding sequence .", + "entities": [] + }, + { + "id": "6300", + "type": "gene", + "text": "We propose that epigenetic features of tissue - specific control and of the control of allelic expression are intricately linked .", + "entities": [] + }, + { + "id": "6301", + "type": "gene", + "text": "Upon serum withdrawal at the permissive temperature , p53 - mediated apoptosis was induced in 50 to 60 % of the cells .", + "entities": [ + "p53" + ] + }, + { + "id": "6302", + "type": "gene", + "text": "Here , it is shown that TAFII250 , the largest subunit of TFIID , contains two tandem bromodomain modules that bind selectively to multiply acetylated histone H4 peptides .", + "entities": [ + "TAFII250", + "TFIID", + "histone H4 peptides" + ] + }, + { + "id": "6303", + "type": "gene", + "text": "Inspired CO2 causing changes from hypo - to normocapnia has previously been shown to improve arterial O2 tension ( PaO2 ) and to reduce alveolar - arterial O2 difference .", + "entities": [] + }, + { + "id": "6304", + "type": "gene", + "text": "Genetic studies in Drosophila have led to the identification of several components of the Notch pathway .", + "entities": [ + "Notch" + ] + }, + { + "id": "6305", + "type": "gene", + "text": "To minimize reflux into the blind loop , a number of technical steps are considered indispensable : 1 ) fluted section of the jejunal stump ; 2 ) isoperistaltic construction of the anastomosis and , particularly , 3 ) the creation of a single or double valve system upstream from the anastomosis by spiral introflexion of the mucosa using seroserous stitches parallel and perpendicular to the ileal lumen .", + "entities": [] + }, + { + "id": "6306", + "type": "gene", + "text": "Sensitivity and specificity was established for the Pharmacia CAP System and the DPC AlaSTAT System by comparison with results of the skin prick test .", + "entities": [] + }, + { + "id": "6307", + "type": "gene", + "text": "Inactivation of the Neurospora crassa mitochondrial outer membrane protein TOM70 by repeat - induced point mutation ( RIP ) causes defects in mitochondrial protein import and morphology .", + "entities": [ + "Neurospora crassa mitochondrial outer membrane protein TOM70" + ] + }, + { + "id": "6308", + "type": "gene", + "text": "In memory of Magdelaine Comtesse", + "entities": [] + }, + { + "id": "6309", + "type": "gene", + "text": "A cDNA clone was isolated from a chicken embryo cDNA library employing a PCR - generated radiolabeled probe specific for the U3 region of the Rous sarcoma virus LTR .", + "entities": [ + "U3 region", + "Rous sarcoma virus LTR" + ] + }, + { + "id": "6310", + "type": "gene", + "text": "Following the results of toxicological experiments in the target animals \" Toxicological Drinking Water Standards for Animals \" can be established .", + "entities": [] + }, + { + "id": "6311", + "type": "gene", + "text": "Chlamydia and cervical cancer : a real association ?", + "entities": [] + }, + { + "id": "6312", + "type": "gene", + "text": "55 + / - 11 % ) , all other parameters showed a significant increase : RS index 5 . 4 + / - 1 . 4 mVolt to 6 . 0 + / - 1 . 7 mVolt ( p less than 0 . 01 ) ; EDD 6 . 3 + / - 0 . 7 to 6 . 8 + / - 0 . 9 cm ( p less than 0 . 001 ) ; HV 1017 + / - 151 ml to 1099 + / - 261 ml ( p less than 0 . 01 ) ; EDV 371 + / - 131 ml to 441 + / - 175 ml ( p less than 0 . 001 ) ; RBV 117 + / - 57 ml to 151 + / - 77 ml ( p less than 0 . 001 ) .", + "entities": [] + }, + { + "id": "6313", + "type": "gene", + "text": "These results confirming the high validity of NOM inhibiting test in the diagnosis of tumoural hyperprolactinemic states , reveal contradictory responses to CD / LD , LD and DOM , with sustain the existence of 2 sub - group of Prolactinomas : with or without a maintained DA central tonus supporting the possibility of different etiopathogenetical factors in inducing a tumoural hyperprolactinemic states .", + "entities": [] + }, + { + "id": "6314", + "type": "gene", + "text": "This multimodality treatment for locally advanced gynecologic tumors appears feasible with modification , and continued work exploring this approach is encouraged .", + "entities": [] + }, + { + "id": "6315", + "type": "gene", + "text": "Consanguinity and migration in the marriages of the region of Nunoa , Santiago , 1850 - 1960", + "entities": [] + }, + { + "id": "6316", + "type": "gene", + "text": "Responses of TLD Mg2SiO4 : Tb and radiophotoluminescent glass to heavy charged particles and space radiation .", + "entities": [] + }, + { + "id": "6317", + "type": "gene", + "text": "Drosophila orthodenticle ( otd ) and murine Otx genes exemplify this , both in terms of expression patterns and mutant phenotypes .", + "entities": [ + "Drosophila orthodenticle", + "otd", + "murine Otx genes" + ] + }, + { + "id": "6318", + "type": "gene", + "text": "Under halothane anesthesia , the flow pneumocardiogram ( PnCG ) and its time derivative ( acceleration pneumocardiogram or dPn / dt ) were transduced during apnea by a small high - gain pneumotachograph .", + "entities": [] + }, + { + "id": "6319", + "type": "gene", + "text": "Possible factors for the development of psychotic symptomatology during group activities and the role of group dynamics acting as stress factors precipitating functional psychoses , especially bipolar manifestations , are discussed .", + "entities": [] + }, + { + "id": "6320", + "type": "gene", + "text": "The frequency of SPs for both the moderate and severe groups was significantly higher than that in patients with a normal MMFCV ( p < . 01 ) ; of 154 arms with a normal MMFCV , only 9 ( 6 % ) had an SP .", + "entities": [] + }, + { + "id": "6321", + "type": "gene", + "text": "Patterns defined by combinations of normal and abnormal laboratory results had decreased the likelihood of PEM from an all - 2 to all - 0 pattern .", + "entities": [] + }, + { + "id": "6322", + "type": "gene", + "text": "In the current model , Wingless / Wnt signal stabilizes Armadillo / beta - catenin , which then accumulates in nuclei and binds TCF / LEF family proteins , forming bipartite transcription factors which activate transcription of Wingless / Wnt responsive genes .", + "entities": [ + "Wingless", + "Wnt", + "Armadillo", + "beta - catenin", + "TCF", + "LEF", + "Wingless", + "Wnt" + ] + }, + { + "id": "6323", + "type": "gene", + "text": "Increased levels of anticardiolipin immunoglobulin G may also cause bleeding .", + "entities": [ + "anticardiolipin immunoglobulin G" + ] + }, + { + "id": "6324", + "type": "gene", + "text": "We studied 120 male and 42 female patients with early CAD who were unrelated to each other but were from families in which at least one other sibling had early CAD .", + "entities": [] + }, + { + "id": "6325", + "type": "gene", + "text": "LMP - 1 is targeted to the plasma membrane , where it binds TRAF , TRADD , and JAK molecules to activate NF - kappaB - , AP - 1 - , and STAT - dependent pathways as does CD40 .", + "entities": [ + "LMP - 1", + "TRAF", + "TRADD", + "JAK molecules", + "NF - kappaB", + "AP - 1", + "STAT", + "CD40" + ] + }, + { + "id": "6326", + "type": "gene", + "text": "Activation of the aboral ectoderm - specific Spec2a gene in blastula - stage sea urchin embryos requires an upstream regulatory region that is part of a repetitive sequence element ( RSR ) associated with all Spec1 / Spec2 genes .", + "entities": [ + "ectoderm - specific Spec2a gene", + "Spec1", + "Spec2" + ] + }, + { + "id": "6327", + "type": "gene", + "text": "The DNA sequencing of the recombinant clones revealed the expression of RXR alpha and RXR beta .", + "entities": [ + "RXR alpha", + "RXR beta" + ] + }, + { + "id": "6328", + "type": "gene", + "text": "Biometric analysis of intraocular lens power required to produce emmetropia : results of 450 implants .", + "entities": [] + }, + { + "id": "6329", + "type": "gene", + "text": "Next , with carcinoma presenting a leather bottle ( linitis plastica type ) of the stomach itself , the II c portion of the stomach consisted of fundic glands ( undifferentiated carcinoma ) shall become the primary focus supporting Nakamura ' s theory .", + "entities": [] + }, + { + "id": "6330", + "type": "gene", + "text": "The DNA sequence of the sulfate activation locus from Escherichia coli K - 12 has been determined .", + "entities": [ + "sulfate activation locus" + ] + }, + { + "id": "6331", + "type": "gene", + "text": "Here , we report that swa5 - 1 is a new temperature - sensitive allele of the clathrin heavy chain gene ( chc1 - 5 ) , which carries a frameshift mutation near the 3 ' end of the CHC1 open reading frame .", + "entities": [ + "swa5 - 1", + "clathrin heavy chain gene", + "chc1 - 5", + "CHC1" + ] + }, + { + "id": "6332", + "type": "gene", + "text": "Mutations in genes encoding PR65 / A subunits have been identified in several different human cancers and the PP2A inhibitor , termed fostriecin , is being tested as an anticancer drug .", + "entities": [ + "PR65 / A subunits", + "PP2A" + ] + }, + { + "id": "6333", + "type": "gene", + "text": "Genomic organization of the human beta - catenin gene ( CTNNB1 ) .", + "entities": [ + "human beta - catenin gene", + "CTNNB1" + ] + }, + { + "id": "6334", + "type": "gene", + "text": "The construct was introduced into BW2001 ( xth - 11 , nfo - 2 ) strain cells of Escherichia coli .", + "entities": [] + }, + { + "id": "6335", + "type": "gene", + "text": "Interspecific complementation tests showed that the P7 proteins are unable to complement P1 parA or parB mutants , and the P1 proteins fail to complement the P7 mutations .", + "entities": [ + "P7 proteins", + "parA", + "parB mutants", + "P1 proteins", + "P7 mutations" + ] + }, + { + "id": "6336", + "type": "gene", + "text": "The oxygen uptake ( VO2 ) , carbon dioxide output ( VCO2 ) , respiratory rate ( fR ) , minute ventilation ( VE ) , alveolar ventilation ( VA ) , alveolar oxygen pressure ( PAO2 ) , and VE / VO2 ratio were higher in the cows , while the tidal volume ( VT ) and physiological dead space ( VD ) were larger in the horses .", + "entities": [] + }, + { + "id": "6337", + "type": "gene", + "text": "26 micrograms PAF or placebo was sprayed into each nasal cavity 8 h and 1 h before a nasal allergen challenge .", + "entities": [ + "PAF" + ] + }, + { + "id": "6338", + "type": "gene", + "text": "Patients and their relatives must be informed about the available effective treatment possibilities and about the right moment for their application in an individual patient .", + "entities": [] + }, + { + "id": "6339", + "type": "gene", + "text": "Mild orbital discomfort occurred in some patients .", + "entities": [] + }, + { + "id": "6340", + "type": "gene", + "text": "The Lm increased and the alveoli / mm2 and elastic recoil pressure decreased .", + "entities": [] + }, + { + "id": "6341", + "type": "gene", + "text": "The patient had developed left - sided low - frequency tremor and hemidystonia after a severe head trauma sustained at 15 years of age .", + "entities": [] + }, + { + "id": "6342", + "type": "gene", + "text": "Hybridization data indicate that 6F6 . 2 corresponds to the previously characterized m6F6 cDNA clone and that 6F6 . 1 and 6F6 . 3 , but not 6F6 . 2 , are adjacent to alpha - type genes .", + "entities": [ + "6F6 . 2", + "m6F6 cDNA clone", + "6F6 . 1", + "6F6 . 3", + "6F6 . 2", + "alpha - type genes" + ] + }, + { + "id": "6343", + "type": "gene", + "text": "Middle - latency auditory evoked potentials ( MAEPs ) were recorded in controls and patients with focal lesions in dorsolateral prefrontal cortex .", + "entities": [] + }, + { + "id": "6344", + "type": "gene", + "text": "Tissue necrosis was evaluated using triphenyltetrazolium staining and was related to two major baseline predictors of infarct size : anatomic risk zone size and coronary collateral flow .", + "entities": [] + }, + { + "id": "6345", + "type": "gene", + "text": "The human gp39 promoter .", + "entities": [ + "human gp39 promoter" + ] + }, + { + "id": "6346", + "type": "gene", + "text": "These findings suggest that the adapter Gab1 may redirect c - Met signaling through PI3K away from a c - Akt / Pak1 cell survival pathway .", + "entities": [ + "Gab1", + "c - Met", + "PI3K", + "c - Akt", + "Pak1" + ] + }, + { + "id": "6347", + "type": "gene", + "text": "The cell cycle - regulated transcription factor E2F is also known to bend DNA upon binding .", + "entities": [ + "E2F" + ] + }, + { + "id": "6348", + "type": "gene", + "text": "Carboxy - terminal Spc110p truncations lacking the calmodulin binding site can support growth and are also phosphorylated in a cell cycle - specific manner .", + "entities": [ + "Spc110p", + "calmodulin" + ] + }, + { + "id": "6349", + "type": "gene", + "text": "The organization of SPP1 genes involved in the replication , DNA packaging and phage assembly proteins resembles the organization of genes of equivalent regions of different E . coli double - stranded DNA phages .", + "entities": [ + "SPP1 genes" + ] + }, + { + "id": "6350", + "type": "gene", + "text": "To test whether Sp1 and zif268 / egr - 1 interact with this motif , gel retardation assays were performed .", + "entities": [ + "Sp1", + "zif268", + "egr - 1" + ] + }, + { + "id": "6351", + "type": "gene", + "text": "Methysergide is a serotonin antagonist and has been demonstrated to reduce wound blood flow and edema formation .", + "entities": [] + }, + { + "id": "6352", + "type": "gene", + "text": "The prevalence and incidence of human immunodeficiency virus types 1 and 2 ( HIV - 1 , HIV - 2 ) , human T - lymphotropic virus types I and II ( HTLV - I / II ) , and syphilitic infections and the association between these infections were determined in a cohort of police officers in Guinea - Bissau .", + "entities": [] + }, + { + "id": "6353", + "type": "gene", + "text": "This report presents the isolation and characterization of the 5 ' - flanking region ( 1 . 2 kb ) and exon 1 of the human RII alpha gene .", + "entities": [ + "human RII alpha gene" + ] + }, + { + "id": "6354", + "type": "gene", + "text": "Doctor Berglund warns members of union pitfalls .", + "entities": [] + }, + { + "id": "6355", + "type": "gene", + "text": "The human 2 ' , 5 ' - oligoadenylate ( 2 - 5A ) synthetases are members of a family interferon ( IFN ) - inducible anti - viral proteins .", + "entities": [ + "human 2 ' , 5 ' - oligoadenylate ( 2 - 5A ) synthetases", + "interferon", + "IFN", + "anti - viral proteins" + ] + }, + { + "id": "6356", + "type": "gene", + "text": "All problems were associated with fractured or lost screws .", + "entities": [] + }, + { + "id": "6357", + "type": "gene", + "text": "R .", + "entities": [] + }, + { + "id": "6358", + "type": "gene", + "text": "Functional and regulatory analysis of the two copies of the fixNOQP operon of Rhizobium leguminosarum strain VF39 .", + "entities": [ + "fixNOQP operon" + ] + }, + { + "id": "6359", + "type": "gene", + "text": "Albumin expression is maintained in the liver by a combination of liver - enriched transcription factors such as CAAT enhancer - binding protein ( C / EBP ) alpha and C / EBPbeta .", + "entities": [ + "CAAT enhancer - binding protein ( C / EBP ) alpha", + "C / EBPbeta" + ] + }, + { + "id": "6360", + "type": "gene", + "text": "Replacement of the CRE with a second copy of the AP - 1 site results in a level of transcriptional activity comparable with that of the wild - type sequence , but replacement of the AP - 1 site with a CRE abolishes activity .", + "entities": [ + "AP - 1 site", + "AP - 1 site" + ] + }, + { + "id": "6361", + "type": "gene", + "text": "The two - wave , 1995 - 1996 National Longitudinal Study of Adolescent Health uses a measure of depressive symptomatology across a 12 - month interval .", + "entities": [] + }, + { + "id": "6362", + "type": "gene", + "text": "Although eight contiguous genes necessary for urease activity have been cloned and sequenced , the transcriptional organization and regulation of specific genes within the Proteus gene cluster has not been investigated in detail .", + "entities": [ + "urease", + "Proteus gene cluster" + ] + }, + { + "id": "6363", + "type": "gene", + "text": "Insert2 contains repetitive non - Ig - related sequences and a small Ig - related sequence .", + "entities": [ + "Ig", + "small Ig - related sequence" + ] + }, + { + "id": "6364", + "type": "gene", + "text": "For various dog vessels in vivo , Q / Dk ranged from 0 . 15 to 47 X 10 ( 5 ) Torr / cm2 .", + "entities": [] + }, + { + "id": "6365", + "type": "gene", + "text": "Cloning and characterization of the murine beta ( 3 ) integrin gene promoter : identification of an interleukin - 4 responsive element and regulation by STAT - 6 .", + "entities": [ + "murine beta ( 3 ) integrin gene", + "interleukin - 4 responsive element", + "STAT - 6" + ] + }, + { + "id": "6366", + "type": "gene", + "text": "Isolation and characterization of a vinculin cDNA from chick - embryo fibroblasts .", + "entities": [ + "vinculin cDNA from chick - embryo fibroblasts" + ] + }, + { + "id": "6367", + "type": "gene", + "text": "To improve test efficiency , we modified our previously introduced contrast / color card test by including a patterned test stimulus and reducing the number of stimuli in both experimental phases .", + "entities": [] + }, + { + "id": "6368", + "type": "gene", + "text": "Most patients with high blood pressure ( BP ) can be managed by using one of 4 classes of compounds : a diuretic , beta blocker , converting enzyme inhibitor or calcium antagonist .", + "entities": [] + }, + { + "id": "6369", + "type": "gene", + "text": "I .", + "entities": [] + }, + { + "id": "6370", + "type": "gene", + "text": "Agranulocytosis treatment with rhGM - CSF", + "entities": [] + }, + { + "id": "6371", + "type": "gene", + "text": "Transient transfection assays using reporter gene constructs containing various lengths of the 5 ' mdr1b sequences revealed that the sequence located between - 247 to - 126 bp was important for the expression of the reporter gene in many different cell lines .", + "entities": [ + "5 ' mdr1b sequences" + ] + }, + { + "id": "6372", + "type": "gene", + "text": "Immunophenotyping in four cases , demonstrated non - B , non - T cell origin in three and pre - B cell origin in one .", + "entities": [] + }, + { + "id": "6373", + "type": "gene", + "text": "In contrast , the MAN showed a unimodal , skewed distribution , with a range from approximately 1 to 14 micron and a maximum at 3 - 4 micron .", + "entities": [] + }, + { + "id": "6374", + "type": "gene", + "text": "Treatment of ovarian neoplasms", + "entities": [] + }, + { + "id": "6375", + "type": "gene", + "text": "In rats bearing Walker - 256 - carcinosarcoma 4 - EPI was effective . ( ABSTRACT TRUNCATED AT 250 WORDS )", + "entities": [] + }, + { + "id": "6376", + "type": "gene", + "text": "DNA sequencing of the DPM1 gene revealed an open reading frame of 801 bases .", + "entities": [ + "DPM1 gene" + ] + }, + { + "id": "6377", + "type": "gene", + "text": "Unfortunately , these preservatives may also interfere with microbiological assays used to determine product sterility or bioburden levels .", + "entities": [] + }, + { + "id": "6378", + "type": "gene", + "text": "Early heparin therapy in 60 children with acute meningococcemia .", + "entities": [] + }, + { + "id": "6379", + "type": "gene", + "text": "Baseline variables associated with CD included a less frequent use of prestroke aspirin and a higher incidence of early CT changes of edema or mass effect or dense middle cerebral artery sign .", + "entities": [] + }, + { + "id": "6380", + "type": "gene", + "text": "Genetic analysis has subsequently identified subpathways of the DNA structure checkpoints , including the reversible arrest of DNA synthesis .", + "entities": [] + }, + { + "id": "6381", + "type": "gene", + "text": "Nernst - - Planck analog equations and stationary state membrane electric potentials .", + "entities": [] + }, + { + "id": "6382", + "type": "gene", + "text": "Genomic and functional characterization of the oas gene family encoding O - acetylserine ( thiol ) lyases , enzymes catalyzing the final step in cysteine biosynthesis in Arabidopsis thaliana .", + "entities": [ + "oas gene family", + "O - acetylserine ( thiol ) lyases" + ] + }, + { + "id": "6383", + "type": "gene", + "text": "A stochastic version of Kernell ' s ( 1968 , 1972 ) model with cumulative afterhyperpolarization ( AHP ) was simulated .", + "entities": [] + }, + { + "id": "6384", + "type": "gene", + "text": "He visited our hospital and left solitary renal cyst was suspected .", + "entities": [] + }, + { + "id": "6385", + "type": "gene", + "text": "Chem .", + "entities": [] + }, + { + "id": "6386", + "type": "gene", + "text": "HSF binds DNA as a trimer , and additional trimers can bind DNA co - operatively .", + "entities": [ + "HSF" + ] + }, + { + "id": "6387", + "type": "gene", + "text": "This reveals a new test for short saphenous incompetence and shows that 14 per cent of varices stem from a saphenopopliteal reflux .", + "entities": [] + }, + { + "id": "6388", + "type": "gene", + "text": "RPS14 introns 3 and 4 both contain Alu sequences .", + "entities": [ + "RPS14", + "Alu" + ] + }, + { + "id": "6389", + "type": "gene", + "text": "MPO was labeled with 1 mCi 125I by a technique of self - labeling in the presence of 10 ( - 4 ) M hydrogen peroxide .", + "entities": [ + "MPO" + ] + }, + { + "id": "6390", + "type": "gene", + "text": "Twenty - six ( 55 % ) ( 95 % CI , 41 - 69 % ) patients experienced > or = grade 3 acute toxicity ( RTOG ) .", + "entities": [] + }, + { + "id": "6391", + "type": "gene", + "text": "Of 7 patients treated with cyclophosphamide , hexamethylmelamine , adriamycin and cisplatin ( CHAP - 5 ) , 6 had measurable disease , of whom 5 yielded a response ( 2 complete responses for 19 + and 40 months and 3 partial responses for 4 , 7 and 8 months ) .", + "entities": [] + }, + { + "id": "6392", + "type": "gene", + "text": "Experimental cardiotoxicity of adriamycin", + "entities": [] + }, + { + "id": "6393", + "type": "gene", + "text": "In the rat rnu allele described here , a nonsense mutation in exon 8 of the whn gene was identified .", + "entities": [ + "rat rnu allele", + "whn gene" + ] + }, + { + "id": "6394", + "type": "gene", + "text": "The cyclins bind to and activate the CDK , which leads to phosphorylation ( and then inhibition ) of the tumor suppressor protein , pRb .", + "entities": [ + "cyclins", + "CDK", + "pRb" + ] + }, + { + "id": "6395", + "type": "gene", + "text": "pRb controls commitment to progress from the G1 to S phase , at least in part by repressing the activity of the E2F transcription factors known to promote cell proliferation .", + "entities": [ + "pRb", + "E2F transcription factors" + ] + }, + { + "id": "6396", + "type": "gene", + "text": "Clinical implication of protein levels of IL - 5 in induced sputum in asthmatic patients .", + "entities": [ + "IL - 5" + ] + }, + { + "id": "6397", + "type": "gene", + "text": "In this study , we have examined the regulation of B - Myb activity by cyclin - Cdks .", + "entities": [ + "B - Myb", + "cyclin", + "Cdks" + ] + }, + { + "id": "6398", + "type": "gene", + "text": "Scientific cooperation of CMEA member countries has been carried out since 1974 under the sponsorship of the Cancer Research Institute , Slovak Academy of Sciences ( Czechoslovakia ) within the framework of CMEA .", + "entities": [] + }, + { + "id": "6399", + "type": "gene", + "text": "National abortion laws usually do not allow abortion when a foetus is independently viable , i . e . from a gestational age of about 24 weeks .", + "entities": [] + }, + { + "id": "6400", + "type": "gene", + "text": "Antibodies raised to the expressed NS3 by immunization of mice detected both NS3 and NS3A in BTV - 10 - infected BHK cells but not in purified BTV - 10 virus particles .", + "entities": [ + "NS3", + "NS3", + "NS3A" + ] + }, + { + "id": "6401", + "type": "gene", + "text": "A hydrodynamic description of the osmotic reflection coefficient with application to the pore theory of transcapillary exchange .", + "entities": [] + }, + { + "id": "6402", + "type": "gene", + "text": "The differentiation and maintenance of a neurotransmitter phenotype is guided by the interaction of exogenous cues with intrinsic genetic machinery .", + "entities": [] + }, + { + "id": "6403", + "type": "gene", + "text": "Mutations at the suf12 locus were isolated in Saccharomyces cerevisiae as extragenic suppressors of + 1 frameshift mutations in glycine ( GGX ) and proline ( CCX ) codons , as well as UGA and UAG nonsense mutations .", + "entities": [ + "suf12 locus" + ] + }, + { + "id": "6404", + "type": "gene", + "text": "The viral LTR was used as the promoter .", + "entities": [ + "viral LTR" + ] + }, + { + "id": "6405", + "type": "gene", + "text": "An 18 - kb genomic clone including sequences encoding for the two GHS - R variants was isolated .", + "entities": [ + "GHS - R variants" + ] + }, + { + "id": "6406", + "type": "gene", + "text": "A possible mechanism is that elevated alveolar pressure and decreased cardiac output eliminate blood flow from corner vessels in nondependent high VA / Q regions .", + "entities": [] + }, + { + "id": "6407", + "type": "gene", + "text": "BACKGROUND : Diazepam , one of the benzodiazepine group of tranquilizers , is used as an adjunctive drug for sedation and for relief of anxiety in the treatment of epilepsy .", + "entities": [] + }, + { + "id": "6408", + "type": "gene", + "text": "The predictive value of a positive flag was 77 . 7 % .", + "entities": [] + }, + { + "id": "6409", + "type": "gene", + "text": "Natural Haemophilus influenzae type b capsular polysaccharide antibodies in 412 infants and children from West Africa ( Burkina - Faso ) and France : a cross - sectional serosurvey .", + "entities": [] + }, + { + "id": "6410", + "type": "gene", + "text": "A comparative study by holographic interferometry of ten porcine bioprosthetic valves ( seven Carpentier - Edwards SAV , two BioImplant and one Valcor ) with five human aortic valves before and after glutaraldehyde treatment is presented .", + "entities": [] + }, + { + "id": "6411", + "type": "gene", + "text": "Simulating the impact during human jumping by means of a 4 - degrees - of - freedom model with time - dependent properties .", + "entities": [] + }, + { + "id": "6412", + "type": "gene", + "text": "Treatment includes both medical and surgical options , with medical therapy further subclassified into pharmacologic and pneumatic dilation .", + "entities": [] + }, + { + "id": "6413", + "type": "gene", + "text": "A central finding is the identification of a GC - rich sequence in the - 99 / - 91 Cp region that is essential for oriPI - EBNA1 - independent as well as oriPI - EBNA1 - dependent activity of the promoter .", + "entities": [ + "Cp", + "EBNA1", + "EBNA1" + ] + }, + { + "id": "6414", + "type": "gene", + "text": "One possible solution is a thin radial forearm free flap .", + "entities": [] + }, + { + "id": "6415", + "type": "gene", + "text": "In vivo epiluminescence microscopy of pigmented skin lesions .", + "entities": [] + }, + { + "id": "6416", + "type": "gene", + "text": "Finally , a complementary footprinting analysis of the upstream region of the constitutively expressed HSC82 gene reveals the presence of three discrete protein complexes .", + "entities": [ + "HSC82 gene" + ] + }, + { + "id": "6417", + "type": "gene", + "text": "Ventilatory management casebook .", + "entities": [] + }, + { + "id": "6418", + "type": "gene", + "text": "European Community Huntington ' s Disease Collaborative Study Group .", + "entities": [] + }, + { + "id": "6419", + "type": "gene", + "text": "On the other hand , cells containing a PTP1C in which the catalytic site had been inactivated through mutagenesis , stably phosphorylated the phosphatase .", + "entities": [ + "PTP1C" + ] + }, + { + "id": "6420", + "type": "gene", + "text": "Heterogeneity of human serum albumin .", + "entities": [ + "human serum albumin" + ] + }, + { + "id": "6421", + "type": "gene", + "text": "There were no significant differences in graft survival between groups with early graft function ( EGF ) and DGF , either in first transplantations or retransplantations .", + "entities": [] + }, + { + "id": "6422", + "type": "gene", + "text": "Our results indicate that the expression of Cktsf1b1 , a gene associated with early development and cell transformation , is sensitive to MKK levels and may be regulated via multiple transcription factor complexes .", + "entities": [ + "Cktsf1b1", + "MKK" + ] + }, + { + "id": "6423", + "type": "gene", + "text": "Fgd3 and FGD1 share a high degree of sequence identity that spans > 560 contiguous amino acid residues .", + "entities": [ + "Fgd3", + "FGD1" + ] + }, + { + "id": "6424", + "type": "gene", + "text": "For the first 30 min following insulin administration , the rate of change in glucose levels was significantly less among the patients with major depressive disorder than among either the patients with dysthymic disorder or the normal control subjects .", + "entities": [ + "insulin" + ] + }, + { + "id": "6425", + "type": "gene", + "text": "We found that RhoA can initiate a linear kinase cascade leading to the activation of ERK6 ( p38 gamma ) , a recently identified member of the p38 family of MAPKs .", + "entities": [ + "RhoA", + "ERK6", + "p38 gamma", + "p38 family" + ] + }, + { + "id": "6426", + "type": "gene", + "text": "Hence follows Kurti ' s demand to mete out appropriate importance to the arguments .", + "entities": [] + }, + { + "id": "6427", + "type": "gene", + "text": "BCL6 encodes a POZ / Zn finger protein , a structure similar to that of many Drosophila developmental regulators and to another protein involved in a human hematopoietic malignancy , PLZF .", + "entities": [ + "BCL6", + "POZ / Zn finger protein", + "PLZF" + ] + }, + { + "id": "6428", + "type": "gene", + "text": "The efficacy of quantitative and qualitative chloride titrators in the estimation of human salt intake .", + "entities": [] + }, + { + "id": "6429", + "type": "gene", + "text": "Advances in hemophilia treatment : a hepatitis - safe factor VIII concentrate", + "entities": [ + "factor VIII" + ] + }, + { + "id": "6430", + "type": "gene", + "text": "Such knowledge could advance diagnosis and treatment of the patient and counseling of the affected family .", + "entities": [] + }, + { + "id": "6431", + "type": "gene", + "text": "The mRNAs of these genes contain respectively one ( YAP1 uORF ) and two ( YAP2 uORF1 and uORF2 ) upstream open reading frames .", + "entities": [ + "YAP1 uORF", + "YAP2 uORF1" + ] + }, + { + "id": "6432", + "type": "gene", + "text": "uORF - mediated modulation of post - termination events on the 5 ' - untranslated region ( 5 ' - UTR ) directs differential control not only of translation but also of mRNA decay .", + "entities": [] + }, + { + "id": "6433", + "type": "gene", + "text": "Sci .", + "entities": [] + }, + { + "id": "6434", + "type": "gene", + "text": "Methisergide ( 0 . 5 mg / kg , i . p . ) , a blocker of serotonin receptors , prevented the development of the antinociceptive effect of serotonin .", + "entities": [ + "serotonin receptors" + ] + }, + { + "id": "6435", + "type": "gene", + "text": "The adeno - associated virus ( AAV ) rep gene encodes four proteins ( Rep78 , Rep68 , Rep52 , and Rep40 ) required for AAV DNA replication and AAV gene regulation .", + "entities": [ + "adeno - associated virus ( AAV ) rep gene", + "Rep78", + "Rep68", + "Rep52", + "Rep40" + ] + }, + { + "id": "6436", + "type": "gene", + "text": "The N - terminal amino acid sequence of Mop has sequence homology with DNA binding proteins .", + "entities": [ + "Mop" + ] + }, + { + "id": "6437", + "type": "gene", + "text": "This article reviews recent information on the frequency , characteristics , and possible pathogenic mechanisms of the vasculitides occurring in patients with the main connective tissue diseases .", + "entities": [] + }, + { + "id": "6438", + "type": "gene", + "text": "Expression of the mouse TSH beta gene , therefore , gives rise to multiple mRNAs , each with a unique 5 ' - untranslated region .", + "entities": [ + "mouse TSH beta gene" + ] + }, + { + "id": "6439", + "type": "gene", + "text": "The course of endotoxin fever remained uninfluenced by ALS .", + "entities": [] + }, + { + "id": "6440", + "type": "gene", + "text": "Cloning and sequencing of the corresponding cDNAs indicates that , via alternative splicing , the rearranged gene codes for two proteins of 84 and 85 kD ( p84 / 85 ) which retain the DNA - binding rel domain and the first five ankyrin repeats , but have lost their carboxy - terminus including the seventh ankyrin repeat .", + "entities": [ + "p84 / 85", + "rel domain", + "ankyrin", + "ankyrin" + ] + }, + { + "id": "6441", + "type": "gene", + "text": "After 10 months of treatment with the conjugated estrogen , both his height and weight showed improvement , while his bone mineral density and bone age were increased .", + "entities": [] + }, + { + "id": "6442", + "type": "gene", + "text": "Northern blot analysis revealed multiple oIGF - I transcripts in a broad band at 800 - 1 , 100 nucleotides and other transcripts of higher molecular weight in liver .", + "entities": [ + "oIGF - I transcripts" + ] + }, + { + "id": "6443", + "type": "gene", + "text": "Here , we demonstrate that kinase - dead but not wild - type forms of Fyn , Lck , and ZAP - 70 block 70Z Cbl - mediated NFAT activation .", + "entities": [ + "Fyn", + "Lck", + "ZAP - 70", + "Cbl", + "NFAT" + ] + }, + { + "id": "6444", + "type": "gene", + "text": "The 5 ' flanking region of the mouse Met - ase - 1 gene also shares considerable regions of identity with the 5 ' flanking region of the rat Met - ase - 1 gene .", + "entities": [ + "mouse Met - ase - 1 gene", + "rat Met - ase - 1 gene" + ] + }, + { + "id": "6445", + "type": "gene", + "text": "Human neutrophil response to short - term exposure to F - 75 cobalt - based alloy .", + "entities": [] + }, + { + "id": "6446", + "type": "gene", + "text": "Both betaAPP mRNA and Abeta levels are increased in trisomy 21 .", + "entities": [ + "betaAPP mRNA", + "Abeta" + ] + }, + { + "id": "6447", + "type": "gene", + "text": "After infection of 293 cells ( which provide complementary E1a - E1b functions ) , both viruses directed equal amounts of P / C - specific mRNA transcription .", + "entities": [ + "E1a", + "E1b", + "P / C - specific mRNA" + ] + }, + { + "id": "6448", + "type": "gene", + "text": "Evolutive morphology of the olfactory bulb in man and certain non - human mammals", + "entities": [] + }, + { + "id": "6449", + "type": "gene", + "text": "In contrast to full - length E2F - 3 , which is expressed only at the G1 / S boundary , E2F - 3B is detected throughout the cell cycle with peak levels in GO where it is associated with Rb .", + "entities": [ + "full - length E2F - 3", + "E2F - 3B", + "Rb" + ] + }, + { + "id": "6450", + "type": "gene", + "text": "Molecular cloning and characterisation of the two homologous genes coding for nitrate reductase in tobacco .", + "entities": [ + "nitrate reductase in tobacco" + ] + }, + { + "id": "6451", + "type": "gene", + "text": "The MICs of this compound against 90 % of these organisms , except for methicillin - resistant S . aureus , ranged from less than or equal to 0 . 006 to 3 . 13 micrograms / ml .", + "entities": [] + }, + { + "id": "6452", + "type": "gene", + "text": "Ultrasonography provides excellent intraoperative evaluation of spinal cord injury .", + "entities": [] + }, + { + "id": "6453", + "type": "gene", + "text": "This is the first study in which mutation screening has been performed for both the EXT1 and EXT2 genes prior to any linkage analysis .", + "entities": [ + "EXT1", + "EXT2 genes" + ] + }, + { + "id": "6454", + "type": "gene", + "text": "Salivary sodium , calcium , and magnesium concentrations were significantly higher in the SLE patients with systemic lupus erythematosus , whereas potassium and total protein concentrations and amylase activity did not differ significantly from the controls .", + "entities": [ + "amylase" + ] + }, + { + "id": "6455", + "type": "gene", + "text": "A cDNA clone pCZ1 , with a 1 . 1 kb insert , was isolated from a NaCl - adapted tobacco cell cDNA library that encodes an apparently full - length 29 kDa protein ( 251 amino acids ) with a calculated pI of 5 . 7 .", + "entities": [] + }, + { + "id": "6456", + "type": "gene", + "text": "Hops , and L .", + "entities": [] + }, + { + "id": "6457", + "type": "gene", + "text": "However , the rtFc gamma R alpha cDNA clone is complementary to at least two different - sized mRNAs expressed by CRNK - 16 cells , contrasting the single Fc gamma R - related mRNA species expressed by human and mouse natural killer cells .", + "entities": [ + "rtFc gamma R alpha cDNA", + "Fc gamma R - related mRNA" + ] + }, + { + "id": "6458", + "type": "gene", + "text": "In agreement with these data , western blot experiments using an antibody directed against the carboxy - terminal portion of the mouse c - kit protein showed that a polypeptide , of the size predicted by the open reading frame of the spermatid - specific c - kit cDNA , accumulates in the latest stages of spermatogenesis and in epididymal spermatozoa .", + "entities": [ + "c - kit protein", + "spermatid - specific c - kit cDNA" + ] + }, + { + "id": "6459", + "type": "gene", + "text": "Class I alpha1 , 2 - mannosidases play an essential role in the elaboration of complex and hybrid N - glycans in mammalian cells .", + "entities": [ + "Class I alpha1 , 2 - mannosidases" + ] + }, + { + "id": "6460", + "type": "gene", + "text": "In addition to DNA - protein interactions , protein - protein interactions with partner proteins often play major roles in targeting ETS - domain proteins to specific promoters .", + "entities": [ + "ETS - domain proteins" + ] + }, + { + "id": "6461", + "type": "gene", + "text": "A cDNA , cak1At , was isolated that suppressed the CAK mutation in budding yeast , and it also complemented a fission yeast CAK mutant .", + "entities": [ + "cak1At", + "CAK mutation", + "fission yeast CAK mutant" + ] + }, + { + "id": "6462", + "type": "gene", + "text": "cak1At encodes a protein related to animal CAKs .", + "entities": [ + "cak1At", + "animal CAKs" + ] + }, + { + "id": "6463", + "type": "gene", + "text": "The region containing both serines is homologous to the N - terminal destruction box of IkappaBalpha , - beta , and - epsilon .", + "entities": [ + "IkappaBalpha , - beta , and - epsilon" + ] + }, + { + "id": "6464", + "type": "gene", + "text": "Autoionization rates and energy levels of triplet nf , v = 1 Rydberg states of H2 .", + "entities": [] + }, + { + "id": "6465", + "type": "gene", + "text": "Human and Chinese hamster S14 protein sequences deduced from the cDNAs are identical .", + "entities": [ + "Chinese hamster S14 protein sequences" + ] + }, + { + "id": "6466", + "type": "gene", + "text": "In the formalin test , however , naloxone attenuated morphine analgesia at the lower doses ( 0 . 1 and 0 . 3 mg / kg ) and potentiated morphine analgesia at the highest dose ( 10 mg / kg ) .", + "entities": [] + }, + { + "id": "6467", + "type": "gene", + "text": "Maximum number of strains ( 39 . 1 % ) were resistant in S . bareilly serotype , followed by S . typhimurium ( 21 . 7 % ) and least in S . typhi ( 17 . 4 % ) .", + "entities": [] + }, + { + "id": "6468", + "type": "gene", + "text": "An open - label , placebo - controlled , randomized , two - way crossover study was performed in 12 healthy volunteers ( between 20 and 44 years of age ) to assess the effect of orlistat , a gastrointestinal lipase inhibitor that reduces dietary fat absorption and is being developed for weight control in obesity , on the absorption of vitamins A and E .", + "entities": [ + "gastrointestinal lipase" + ] + }, + { + "id": "6469", + "type": "gene", + "text": "In Arabidopsis , the induction of a dehydration - responsive gene , rd22 , is mediated by abscisic acid ( ABA ) and requires protein biosynthesis for ABA - dependent gene expression .", + "entities": [ + "rd22" + ] + }, + { + "id": "6470", + "type": "gene", + "text": "These results indicate that residue 266 serves as a \" protein sensor \" of altered minor groove interactions and identifies which base pair interactions are altered by these lesions .", + "entities": [] + }, + { + "id": "6471", + "type": "gene", + "text": "SV increased less in SHR , mainly reflecting the reduced diastolic compliance of the hypertrophied SHR left ventricle and the consequent rightward shift of its Frank - Starling curve .", + "entities": [] + }, + { + "id": "6472", + "type": "gene", + "text": "Multiple chemical sensitivity ( MCS ) is a syndrome in which multiple symptoms reportedly occur with low - level chemical exposure .", + "entities": [] + }, + { + "id": "6473", + "type": "gene", + "text": "However , besides the kinase catalytic domain and double leucine / isoleucine zippers , there was no significant homology with known proteins .", + "entities": [] + }, + { + "id": "6474", + "type": "gene", + "text": "The protein - tyrosine kinase fer associates with signaling complexes containing insulin receptor substrate - 1 and phosphatidylinositol 3 - kinase .", + "entities": [ + "fer", + "insulin receptor substrate - 1", + "phosphatidylinositol 3 - kinase" + ] + }, + { + "id": "6475", + "type": "gene", + "text": "The cis - acting regulatory properties of an 872 bp promoter fragment of a B . napus oleosin gene were examined by analysis of beta - glucuronidase ( GUS ) expression in transgenic tobacco plants containing an oleosin promoter - GUS transcriptional fusion .", + "entities": [ + "oleosin gene", + "beta - glucuronidase", + "GUS", + "oleosin promoter", + "GUS" + ] + }, + { + "id": "6476", + "type": "gene", + "text": "Because of the probable causal relationship between constitutive p210 ( bcr / abl ) protein tyrosine kinase activity and manifestations of chronic - phase chronic myelogenous leukemia ( CML ; myeloid expansion ) , a key goal is to identify relevant p210 substrates in primary chronic - phase CML hematopoietic progenitor cells .", + "entities": [ + "p210", + "bcr", + "abl", + "protein tyrosine kinase", + "p210" + ] + }, + { + "id": "6477", + "type": "gene", + "text": "The low number of false positives indicates that our scheme would not confuse the radiologist by suggesting normal regions as suspicious .", + "entities": [] + }, + { + "id": "6478", + "type": "gene", + "text": "Recommendations to deal with these and related issues are presented .", + "entities": [] + }, + { + "id": "6479", + "type": "gene", + "text": "Influence of metoprolol treatment on sympatho - adrenal activation of fibrinolysis .", + "entities": [] + }, + { + "id": "6480", + "type": "gene", + "text": "MICs of four antifungal agents ( 5 - fluorocytosine , miconazole , ketoconazole , and amphotericin B ) for 84 clinical isolates of various Candida species were then determined with both media in agar dilution and microtiter broth dilution systems .", + "entities": [] + }, + { + "id": "6481", + "type": "gene", + "text": "This concept is supported by the identification of RH - like genes in non human primates .", + "entities": [ + "RH - like genes" + ] + }, + { + "id": "6482", + "type": "gene", + "text": "Forty - eight sequences , 30 not previously identified as IR - responsive , were significantly regulated by IR .", + "entities": [] + }, + { + "id": "6483", + "type": "gene", + "text": "Since only 58 % of our sample could be adequately classified with one diagnosis , we expect that the ASDC nosology will need to evolve further .", + "entities": [] + }, + { + "id": "6484", + "type": "gene", + "text": "E 50 , 843 ( 1994 ) ] .", + "entities": [] + }, + { + "id": "6485", + "type": "gene", + "text": "In adult tissues , it was less restricted , indicating that RAFTK expression is developmentally up - regulated .", + "entities": [ + "RAFTK" + ] + }, + { + "id": "6486", + "type": "gene", + "text": "Preventive effect of ONO - 3708 on thrombosis and vasospasms in vitro and in vivo .", + "entities": [] + }, + { + "id": "6487", + "type": "gene", + "text": "Proteasomes are the multisubunit protease involved in the generation of peptides presented by MHC class I molecules .", + "entities": [ + "MHC class I molecules" + ] + }, + { + "id": "6488", + "type": "gene", + "text": "Finally , profiling of a gcn4Delta mutant uncovered an alternative induction pathway operating at many Gcn4p target genes in histidine - starved cells .", + "entities": [ + "gcn4Delta mutant", + "Gcn4p target genes" + ] + }, + { + "id": "6489", + "type": "gene", + "text": "Collectively , these experiments demonstrate that CFTR ' s NBF1 + R region and its NBF2 domain , after folding separately as distinct units , have a strong propensity to interact and that this interaction is stable in the absence of added nucleotides or exogenously induced phosphorylation .", + "entities": [ + "CFTR ' s NBF1 + R region", + "NBF2 domain" + ] + }, + { + "id": "6490", + "type": "gene", + "text": "The standard principles of surgical management must be adhered to when using Sandostatin to treat patients with these disorders .", + "entities": [] + }, + { + "id": "6491", + "type": "gene", + "text": "Validity of immunohistology and in situ hybridization in the differential diagnosis of cytomegalovirus pneumonia and idiopathic interstitial pneumonia after allogenic bone marrow transplantation", + "entities": [] + }, + { + "id": "6492", + "type": "gene", + "text": "The monoclonal immunoglobulin products of plasma cell neoplasm can give rise to a variety of manifestations including hyperviscosity , amyloidosis , cryoglobulinemia , neuropathy , and renal failure .", + "entities": [ + "immunoglobulin" + ] + }, + { + "id": "6493", + "type": "gene", + "text": "GW Gamma approximation for electron self - energies in semiconductors and insulators .", + "entities": [] + }, + { + "id": "6494", + "type": "gene", + "text": "Current world literature .", + "entities": [] + }, + { + "id": "6495", + "type": "gene", + "text": "G - DNA is a four - stranded DNA structure with diverse putative biological roles .", + "entities": [] + }, + { + "id": "6496", + "type": "gene", + "text": "In the present study , we have investigated the functional role of the other MAP kinases in PDGF - mediated cellular responses .", + "entities": [ + "MAP kinases", + "PDGF" + ] + }, + { + "id": "6497", + "type": "gene", + "text": "An increase in the level of serum enzymes , such as aspartate transaminase , alkaline phosphatase , creatine phosphokinase , lactate dehydrogenase after D . russelli venom injection in albino rats is indicative of cell or tissue damage .", + "entities": [ + "aspartate transaminase", + "alkaline phosphatase", + "creatine phosphokinase", + "lactate dehydrogenase" + ] + }, + { + "id": "6498", + "type": "gene", + "text": "Each causative organism has a species - specific preference and requirement for temperature , salinity , pH , the basic nutrients , and growth factors , and the toxin formation is affected by these environmental factors .", + "entities": [] + }, + { + "id": "6499", + "type": "gene", + "text": "CONCLUSIONS : While INR correction may be achieved by all the above methods , that relating log reference INR to log local prothrombin time by linear regression analysis is the simplest to perform .", + "entities": [ + "prothrombin" + ] + }, + { + "id": "6500", + "type": "gene", + "text": "METHODS : We obtained maximal inspiratory and expiratory flow - volume curves in 41 unselected patients with essential tremor ( 14 males , 27 females , age 61 . 7 + / - 2 . 14 years ) .", + "entities": [] + }, + { + "id": "6501", + "type": "gene", + "text": "Courses were repeated monthly upon recovery of myelosuppression .", + "entities": [] + }, + { + "id": "6502", + "type": "gene", + "text": "In contrast , injection of a plasmid encoding simian virus 40 small t antigen , which interacts with PP2A to inhibit its activity towards several phosphoprotein substrates , had no effect on the phosphorylation state of CREB in stimulated or unstimulated NIH 3T3 cells .", + "entities": [ + "simian virus 40 small t antigen", + "PP2A", + "CREB" + ] + }, + { + "id": "6503", + "type": "gene", + "text": "To examine whether thiamine ( vitamin B1 ) deficiency is associated with recurrent aphthous stomatitis , we studied vitamin B1 levels in 70 patients with recurrent aphthous stomatitis and in 50 members of a control group .", + "entities": [] + }, + { + "id": "6504", + "type": "gene", + "text": "Genetic interactions between BCK2 and other pathway components suggested that BCK2 functions on a common pathway branch with PPZ1 and PPZ2 .", + "entities": [ + "BCK2", + "BCK2", + "PPZ1", + "PPZ2" + ] + }, + { + "id": "6505", + "type": "gene", + "text": "This region of 60 amino acids may be involved in coiled - coil interactions similar to those that facilitate the filament formation in the rod region .", + "entities": [] + }, + { + "id": "6506", + "type": "gene", + "text": "One air embolism occurred ; this was the only filter - or retrieval - related complication .", + "entities": [] + }, + { + "id": "6507", + "type": "gene", + "text": "These results suggest that Thr115 may play an important role in the regulation of MyoD function under conditions of high mitogenesis .", + "entities": [ + "MyoD" + ] + }, + { + "id": "6508", + "type": "gene", + "text": "IA - CT with cisplatin 50 mg and doxorubicin 30 mg was administered by one shot method in bilateral internal iliac arteries .", + "entities": [] + }, + { + "id": "6509", + "type": "gene", + "text": "A tyrosine - based sorting signal in the beta2 integrin cytoplasmic domain mediates its recycling to the plasma membrane and is required for ligand - supported migration .", + "entities": [ + "beta2 integrin cytoplasmic domain" + ] + }, + { + "id": "6510", + "type": "gene", + "text": "Although antisperm antibodies are associated with infertility , many hospital laboratories do not test for these antibodies .", + "entities": [] + }, + { + "id": "6511", + "type": "gene", + "text": "NSCL - 1 is expressed in a larger number of these cell lines .", + "entities": [ + "NSCL - 1" + ] + }, + { + "id": "6512", + "type": "gene", + "text": "In summary , WT1 is enriched by oligo ( dT ) chromatography , as are U2AF65 , the U5 small nuclear RNP - associated protein p116 and hnRNP A1 .", + "entities": [ + "WT1", + "U2AF65", + "p116", + "A1" + ] + }, + { + "id": "6513", + "type": "gene", + "text": "Alternative transcript of the nonselective - type endothelin receptor from rat brain .", + "entities": [ + "endothelin receptor" + ] + }, + { + "id": "6514", + "type": "gene", + "text": "At termination ( gd 20 ) , confirmed - pregnant females ( 21 to 25 per group ) were evaluated for clinical status and gestational outcome ; live fetuses were examined for external , visceral , and skeletal malformations .", + "entities": [] + }, + { + "id": "6515", + "type": "gene", + "text": "Similarly , a human but not a bovine alpha transgene was expressed in placenta in transgenic mice .", + "entities": [ + "bovine alpha transgene" + ] + }, + { + "id": "6516", + "type": "gene", + "text": "After treatment with tunicamycin , the transfectants secreted unglycosylated 18 - kDa polypeptides which could also bind IgE .", + "entities": [ + "IgE" + ] + }, + { + "id": "6517", + "type": "gene", + "text": "Once P - 450scc mRNA is induced as a consequence of the LH / hCG surge it is constitutively maintained by luteinized cells in vivo ( 0 - 4 days ) and in vitro ( 0 - 9 days ) in the absence of gonadotropins , is susceptible to modulation by prolactin and is no longer regulated by cAMP .", + "entities": [ + "P - 450scc mRNA", + "LH", + "hCG", + "gonadotropins", + "prolactin" + ] + }, + { + "id": "6518", + "type": "gene", + "text": "The dnaK operon of Bacillus subtilis is heptacistronic .", + "entities": [ + "dnaK operon of Bacillus subtilis" + ] + }, + { + "id": "6519", + "type": "gene", + "text": "OKT3 prophylaxis improves long - term renal graft survival in high - risk patients as compared to cyclosporine : combined results from the prospective , randomized Belgian and US studies .", + "entities": [ + "OKT3" + ] + }, + { + "id": "6520", + "type": "gene", + "text": "Facts on the Economic Recovery Tax Act of 1981 for speech - language pathologists and audiologists .", + "entities": [] + }, + { + "id": "6521", + "type": "gene", + "text": "Consistent with this , we show that peptides representing docking sites within the target substrates Elk - 1 and p90 ( rsk ) inhibit ERK - dependent activation of MKP - 3 .", + "entities": [ + "Elk - 1", + "p90", + "rsk", + "ERK", + "MKP - 3" + ] + }, + { + "id": "6522", + "type": "gene", + "text": "After the first 28 patients vincristine was replaced by teniposide ( VM - 26 ) due to neurotoxicity .", + "entities": [] + }, + { + "id": "6523", + "type": "gene", + "text": "The pre - mRNA splicing factor U2AF ( U2 small nuclear ribonucleoprotein particle [ snRNP ] auxiliary factor ) plays a critical role in 3 ' splice site selection .", + "entities": [ + "U2AF", + "U2 small nuclear ribonucleoprotein particle [ snRNP ] auxiliary factor" + ] + }, + { + "id": "6524", + "type": "gene", + "text": "Following extended recovery hippocampal EEG was normal despite extensive cellular loss in areas CA3 and CA4 .", + "entities": [] + }, + { + "id": "6525", + "type": "gene", + "text": "We identified telSMN mutations in 11 of these unrelated SMA - like individuals who carry a single copy of telSMN : these include two frameshift mutations ( 800ins11 and 542delGT ) and three missense mutations ( A2G , S262I , and T274I ) .", + "entities": [ + "telSMN", + "telSMN" + ] + }, + { + "id": "6526", + "type": "gene", + "text": "D - cyclin - cdk activity is required for Rb phosphorylation in v - Jun - transformed cells , since ectopic expression of the cdk4 - and cdk6 - specific inhibitor p16 ( INK4A ) inhibits both DNA synthesis and cell proliferation .", + "entities": [ + "D - cyclin", + "cdk", + "Rb", + "v - Jun", + "cdk4", + "cdk6", + "p16", + "INK4A" + ] + }, + { + "id": "6527", + "type": "gene", + "text": "Deletion analysis showed that the NF - 4FA , NF - 4FB , and AP - 1 sequences are each necessary for full enhancer activity .", + "entities": [ + "NF - 4FA", + "NF - 4FB", + "AP - 1" + ] + }, + { + "id": "6528", + "type": "gene", + "text": "A 15 . 1 kb fragment of the yeast genome was allocated to the centromeric region of chromosome XIV by genetic mapping .", + "entities": [] + }, + { + "id": "6529", + "type": "gene", + "text": "The deleted nucleotide sequence corresponded to sequences that , by analogy to the organization of the type I collagen genes , should be precisely encoded by exon 41 of the COL3A1 gene .", + "entities": [ + "type I collagen genes", + "COL3A1 gene" + ] + }, + { + "id": "6530", + "type": "gene", + "text": "The interaction does not depend on the presence of the correct amino - terminal DNA binding domain or the amino acid sequences between the DNA binding domain and the last ten amino acids .", + "entities": [] + }, + { + "id": "6531", + "type": "gene", + "text": "The COOH - terminal 46 codons of slyD encode a remarkable histidine - rich peptide sequence which is at least partly dispensable for slyD function in E - mediated lysis .", + "entities": [ + "slyD", + "slyD", + "E" + ] + }, + { + "id": "6532", + "type": "gene", + "text": "In the present study , we have determined the ICBP90 gene structure by screening of a human placenta genomic library and PCR analysis .", + "entities": [ + "ICBP90 gene" + ] + }, + { + "id": "6533", + "type": "gene", + "text": "During the cloning by reverse transcriptase - polymerase chain reaction of the human HIF - 1alpha subunit , we isolated two cDNA clones which corresponded to alternative splicing of the HIF - 1alpha gene .", + "entities": [ + "reverse transcriptase", + "human HIF - 1alpha subunit", + "HIF - 1alpha gene" + ] + }, + { + "id": "6534", + "type": "gene", + "text": "Crossover in the specific heat of dilute magnets induced by critical spin - wave dynamics .", + "entities": [] + }, + { + "id": "6535", + "type": "gene", + "text": "In this study , we examine the effects of Msx2 expression on OC promoter activation ( luciferase reporter ) by FGF2 / FSK and calcitriol in MC3T3 - E1 osteoblasts .", + "entities": [ + "Msx2", + "OC promoter", + "luciferase reporter", + "FGF2", + "FSK" + ] + }, + { + "id": "6536", + "type": "gene", + "text": "Roentgenographically , the lesion was usually a well - defined and benign appearing one , either purely lytic ( 3 cases ) or with central radiodensity ( 2 cases ) .", + "entities": [] + }, + { + "id": "6537", + "type": "gene", + "text": "Ras is not associated with the tegument .", + "entities": [ + "Ras" + ] + }, + { + "id": "6538", + "type": "gene", + "text": "Baseline electrocorticography over the surface of the temporal lobe and depth electrode recordings in the amygdala and hippocampus were obtained , followed by 10 min of recording before and after the i . v . administration of both alfentanil 50 microg / kg and fentanyl 10 microg / kg .", + "entities": [] + }, + { + "id": "6539", + "type": "gene", + "text": "Recombinant erythropoietin ( r - HuEPO ) in the treatment of anemia in multiple myeloma", + "entities": [ + "Recombinant erythropoietin", + "r - HuEPO" + ] + }, + { + "id": "6540", + "type": "gene", + "text": "Studies on the life cycle of Haplorchis pumilio ( Looss , 1896 ) Looss , 1899 with morphological redescription of larval and adult stages .", + "entities": [] + }, + { + "id": "6541", + "type": "gene", + "text": "Anti - anxiety action of diazepam after intra - amygdaloid application in the rat .", + "entities": [] + }, + { + "id": "6542", + "type": "gene", + "text": "In addition , the consensus amino acid motif for serine threonine receptor kinases was also present .", + "entities": [ + "serine threonine receptor kinases" + ] + }, + { + "id": "6543", + "type": "gene", + "text": "Lymphocyte subpopulations , serum IgE and total eosinophil counts in patients with bronchial asthma .", + "entities": [ + "serum IgE" + ] + }, + { + "id": "6544", + "type": "gene", + "text": "To understand the regulatory mechanism controlling its expression at low temperature , the promoter region has been characterized .", + "entities": [] + }, + { + "id": "6545", + "type": "gene", + "text": "The capacity to repair 8 - OxoG has been measured in cell - free extracts of wild - type and ogg1 strains using a 34mer DNA fragment containing a single 8 - OxoG residue paired with a cytosine ( 8 - OxoG / C ) as a substrate .", + "entities": [ + "ogg1" + ] + }, + { + "id": "6546", + "type": "gene", + "text": "STAT5A mutations in the Src homology 2 ( SH2 ) and SH3 domains did not alter the BTK - mediated tyrosine phosphorylation .", + "entities": [ + "STAT5A", + "Src homology 2", + "SH2", + "SH3 domains", + "BTK" + ] + }, + { + "id": "6547", + "type": "gene", + "text": "OBJECTIVE : To investigate the association between complete congenital heart block ( CCHB ) in the fetus and adult disease .", + "entities": [] + }, + { + "id": "6548", + "type": "gene", + "text": "Immunostaining of cells transfected with these constructs revealed that both the myristoylated and nonmyristoylated mutants were localized in nuclei , whereas wild - type PKC alpha was primarily cytoplasmic and perinuclear .", + "entities": [ + "wild - type PKC alpha" + ] + }, + { + "id": "6549", + "type": "gene", + "text": "The 12S E1A product does not activate a TRE sequence , but cotransfection with c - jun circumvents this lack of stimulation .", + "entities": [ + "12S E1A product", + "c - jun" + ] + }, + { + "id": "6550", + "type": "gene", + "text": "Cytogenetic studies were performed in lymphocytes from hospital workers exposed to low doses of radiation ( 1 . 6 - 42 . 71 mSv ) .", + "entities": [] + }, + { + "id": "6551", + "type": "gene", + "text": "Therefore , the molecular mechanisms of the estrogen action that govern the lactoferrin gene expression differ between mouse and human .", + "entities": [ + "lactoferrin gene" + ] + }, + { + "id": "6552", + "type": "gene", + "text": "TT cells , a human MTC cell line expressing MEN 2A type RET , display transcriptionally active RelA ( p65 ) in the nucleus .", + "entities": [ + "MEN 2A type RET", + "RelA ( p65 )" + ] + }, + { + "id": "6553", + "type": "gene", + "text": "PBSX is induced by agents which elicit the SOS response .", + "entities": [ + "PBSX" + ] + }, + { + "id": "6554", + "type": "gene", + "text": "Alignment of the amino acid sequences surrounding Tyr - 766 with corresponding regions of other FGFRs revealed conserved tyrosine residues in all known members of the FGFR family .", + "entities": [ + "FGFRs", + "FGFR family" + ] + }, + { + "id": "6555", + "type": "gene", + "text": "Human PDK1 is homologous to the Drosophila protein kinase DSTPK61 , which has been implicated in the regulation of sex differentiation , oogenesis and spermatogenesis .", + "entities": [ + "Human PDK1", + "Drosophila protein kinase DSTPK61" + ] + }, + { + "id": "6556", + "type": "gene", + "text": "Human T - cell leukemia virus type I ( HTLV - I ) Tax is a potent transcriptional regulator that can activate or repress specific cellular genes and that has been proposed to contribute to leukemogenesis in adult T - cell leukemia .", + "entities": [ + "Human T - cell leukemia virus type I ( HTLV - I ) Tax" + ] + }, + { + "id": "6557", + "type": "gene", + "text": "Persistent activation of mitogen - activated protein kinases p42 and p44 and ets - 2 phosphorylation in response to colony - stimulating factor 1 / c - fms signaling .", + "entities": [ + "mitogen - activated protein kinases p42", + "p44", + "ets - 2", + "colony - stimulating factor 1", + "c - fms" + ] + }, + { + "id": "6558", + "type": "gene", + "text": "Ethylene glycol and diethylene glycol were each administered once weekly subcutaneously to groups of 100 female NMRI mice at 3 dosages ( 30 ; 10 und 3 mg single dose per mouse ) .", + "entities": [] + }, + { + "id": "6559", + "type": "gene", + "text": "The financial impact of childhood asthma has not been assessed since Vance and Taylor reported their data in Annals of Allergy 13 years ago .", + "entities": [] + }, + { + "id": "6560", + "type": "gene", + "text": "Bulbar pouches were perfused with solutions of 0 . 9 % Na C1 , 0 . 1 N HC1 , 40 % glucose , 40 % NaC1 , and 40 % peptone or with 0 . 1 % solutions of acetylcholine chloride .", + "entities": [] + }, + { + "id": "6561", + "type": "gene", + "text": "Many children with BGC are delayed in their development , but calcifications are not directly related to specific forms of neurologic dysfunction .", + "entities": [] + }, + { + "id": "6562", + "type": "gene", + "text": "Lyn kinase immunoprecipitated from lysates of irradiated BCP as well as a full - length glutathione S - transferase ( GST ) - Lyn fusion protein - phosphorylated recombinant human p34cdc2 on tyrosine 15 .", + "entities": [ + "Lyn kinase", + "glutathione S - transferase", + "GST", + "Lyn", + "recombinant human p34cdc2" + ] + }, + { + "id": "6563", + "type": "gene", + "text": "RESULTS : In the AGA group , both fetal and maternal serum prolactin concentration increased significantly with gestation ( P < 0 . 001 and P < 0 . 01 , respectively ) .", + "entities": [ + "prolactin" + ] + }, + { + "id": "6564", + "type": "gene", + "text": "2 patients ( 11 % ) had significant morbidity 502 and 529 days respectively after transplantation .", + "entities": [] + }, + { + "id": "6565", + "type": "gene", + "text": "The cis - acting element , identified as CACGTGACCCG , is located 34 bp upstream from the transcription initiation site , and contains the core sequence of the upstream promoter sequence of Ad2MLP .", + "entities": [ + "Ad2MLP" + ] + }, + { + "id": "6566", + "type": "gene", + "text": "Ha - RasV12 and activated proteins in both the extra - cellular regulated kinase ( ERK ) and the stress - activated protein kinase ( SAPK ) or Jun N - terminal kinase ( JNK ) cascades independently stimulated PEA3 - mediated gene expression .", + "entities": [ + "Ha - RasV12", + "extra - cellular regulated kinase", + "ERK", + "stress - activated protein kinase", + "SAPK", + "Jun N - terminal kinase", + "JNK", + "PEA3" + ] + }, + { + "id": "6567", + "type": "gene", + "text": "In the ISO group , at pre - DEX , CBF increased from 86 + / - 8 to 166 + / - 19 mL . min - 1 . 100 g - 1 in response to hypercapnia ( PCO2 approximately 90 mmHg ) . ( ABSTRACT TRUNCATED AT 250 WORDS )", + "entities": [] + }, + { + "id": "6568", + "type": "gene", + "text": "Like pineal melatonin , serum melatonin was high at mid - dark and low at mid - light .", + "entities": [] + }, + { + "id": "6569", + "type": "gene", + "text": "Reporter constructs function in a parallel manner , demonstrating the key role of the AhR in constitutive as well as TCDD - induced expression of Cyp1B1 in mouse embryo fibroblasts .", + "entities": [ + "AhR", + "Cyp1B1" + ] + }, + { + "id": "6570", + "type": "gene", + "text": "It is concluded that attention to these issues can substantially improve the quality of research on AIDS related behaviors on Black communities .", + "entities": [] + }, + { + "id": "6571", + "type": "gene", + "text": "These results illustrate an important role for La in RNA production by demonstrating its ability to clear the termination sites of class III templates , thereby promoting efficient use of transcription complexes by pol III .", + "entities": [ + "La", + "pol III" + ] + }, + { + "id": "6572", + "type": "gene", + "text": "The correct termination of retroviral transcripts at the 3 ' LTR R / U5 junction is primarily dependent on the canonical AAUAAA polyadenylation signal , so we have analyzed the effect of mutating the polyadenylation signal sequences on the properties of a selectable murine retroviral vector .", + "entities": [] + }, + { + "id": "6573", + "type": "gene", + "text": "313 , 98 - 102 ) .", + "entities": [] + }, + { + "id": "6574", + "type": "gene", + "text": "For the sample of systematic reviews drawn from ACP Journal Club ( n = 103 ) , the PubMed strategy achieved a sensitivity of 97 % ( CI , 91 % to 99 % ) .", + "entities": [] + }, + { + "id": "6575", + "type": "gene", + "text": "I .", + "entities": [] + }, + { + "id": "6576", + "type": "gene", + "text": "3 - ( N - Alkyl - N - 2 - chloroethylaminomethyl ) - 5 - or 7 - halogenobenzo [ b ] thiophen hydrochlorides .", + "entities": [] + }, + { + "id": "6577", + "type": "gene", + "text": "In 30 dogs the left limb ( tail ) of the pancreas was removed but left in the abdominal cavity after cessation of blood flow to produce warm ischemia for 30 , 60 , and 120 min ( 10 dogs at each time point ) , and then was flushed with cold Ringers ' lactate and transplanted to the iliac vessels .", + "entities": [] + }, + { + "id": "6578", + "type": "gene", + "text": "The population studied comprised 4472 men and 5212 women aged 30 - 74 years , without coronary heart disease , who had CRP measurements in the Third National Health and Nutrition Examination Survey ( NHANES III ) .", + "entities": [ + "CRP" + ] + }, + { + "id": "6579", + "type": "gene", + "text": "RESULTS : Nodular opacities , mainly centrilobular in distribution , were the most common finding , seen in 21 ( 72 % ) and 15 ( 65 % ) of patients with MTB and NTMB , respectively .", + "entities": [] + }, + { + "id": "6580", + "type": "gene", + "text": "BACKGROUND : The aim of this study was to determine and compare interleukin - 6 ( IL - 6 ) levels in gingival crevicular fluid ( GCF ) and clinical periodontal findings in patients with rheumatoid arthritis ( RA ) and adult periodontitis ( AP ) .", + "entities": [ + "interleukin - 6", + "IL - 6" + ] + }, + { + "id": "6581", + "type": "gene", + "text": "The results suggest that the presence or absence per se of keratan sulfate on native G1 - G2 does not affect the activity of atrolysin C toward the two sites .", + "entities": [] + }, + { + "id": "6582", + "type": "gene", + "text": "However , it was synthesized at both temperatures after addition of A23187 .", + "entities": [] + }, + { + "id": "6583", + "type": "gene", + "text": "The ARF promoter was also found to be highly responsive to E2F1 expression , in keeping with previous results at the RNA level .", + "entities": [ + "ARF promoter", + "E2F1" + ] + }, + { + "id": "6584", + "type": "gene", + "text": "In subjects ( n = 5 ) with quadriplegia and reduced sympathetic tone secondary to cervical cord trauma , TcpO2 at 42 degrees C and vasodilation index were increased ( 45 . 0 mmHg and 0 . 61 ) ; TcpO2 at 45 degrees C did not change .", + "entities": [] + }, + { + "id": "6585", + "type": "gene", + "text": "This hypothesis was tested by introducing mutations at each of the three histidine pairs , the H382 - X2 - H385 pair , the H411 - X2 - H414 pair and the H430 - X5 - H436 pair , which constitute the histidine - rich region near the C terminus of gp17 .", + "entities": [ + "gp17" + ] + }, + { + "id": "6586", + "type": "gene", + "text": "The potential for highly reactive nanoparticles ( RNP ) to absorb destructively , i . e . to neutralize highly toxic substances such as the warfare agents GA , GB , HD and VX , has been demonstrated in the laboratory .", + "entities": [] + }, + { + "id": "6587", + "type": "gene", + "text": "The region that imparts inducibility by IL - 1 or TNF ( positions - 165 to - 58 ) contains potential binding sites for IRF - 1 and - 2 , AP - 1 , and NF - IL - 6 .", + "entities": [ + "IL - 1", + "TNF", + "IRF - 1 and - 2", + "AP - 1", + "NF - IL - 6" + ] + }, + { + "id": "6588", + "type": "gene", + "text": "Fast goal - directed voluntary movements of the human upper extremity are known to be associated with three distinct bursts of EMG activity in antagonistic muscles .", + "entities": [] + }, + { + "id": "6589", + "type": "gene", + "text": "The levels of both MAP1 - specific and MAP2 - specific mRNAs decline in the postnatal developing brain ; the level of MAP1 - specific mRNA also increases slightly in rat PC12 cells upon exposure to nerve growth factor .", + "entities": [ + "MAP1 - specific and MAP2 - specific mRNAs", + "MAP1 - specific mRNA", + "nerve growth factor" + ] + }, + { + "id": "6590", + "type": "gene", + "text": "Sequence analysis showed that the 5 ' - flanking region upstream to the ATG codon did not contain a conventional TATA box .", + "entities": [] + }, + { + "id": "6591", + "type": "gene", + "text": "Positioning this uORF , together with its accompanying Kozak sequences , between a heterologous promoter from SV40 and a CAT reporter gene resulted in marked inhibition of CAT protein production without a decrease in CAT mRNA .", + "entities": [ + "CAT reporter gene", + "CAT protein", + "CAT mRNA" + ] + }, + { + "id": "6592", + "type": "gene", + "text": "The pattern of RNase E digestion of finP305 RNA differed from FinP , and GST - FinO did not protect finP305 RNA from cleavage in vitro .", + "entities": [ + "RNase E", + "finP305 RNA", + "FinP", + "GST", + "FinO", + "finP305 RNA" + ] + }, + { + "id": "6593", + "type": "gene", + "text": "272 , 1904 ] .", + "entities": [] + }, + { + "id": "6594", + "type": "gene", + "text": "Tumor necrosis factor alpha , the cytokine that participates in the autocrine growth control of hairy cell leukemia has strong bone resorptive properties .", + "entities": [ + "Tumor necrosis factor alpha" + ] + }, + { + "id": "6595", + "type": "gene", + "text": "A partial cDNA sequence indicated that the T lymphocyte early - activation gene ( Tea ) encodes a protein related to the dual - function ecotropic retrovirus receptor / cationic amino acid transporter ( ecoR / CAT1 ) , and RNA blots suggested highest Tea expression in T lymphocytes and liver ( MacLeod , C . L . , Finley , K . , Kakuda , D .", + "entities": [ + "T lymphocyte early - activation gene", + "Tea", + "ecotropic retrovirus receptor", + "cationic amino acid transporter", + "ecoR", + "CAT1", + "Tea" + ] + }, + { + "id": "6596", + "type": "gene", + "text": "The fragments are separated and directly sized by agarose gel electrophoresis .", + "entities": [] + }, + { + "id": "6597", + "type": "gene", + "text": "Though hepatomegaly and mild elevation of enzymes can be observed in a significant proportion of patients , involvement of liver leading to acute hepatitis or liver cell necrosis is a relatively uncommon complication in P . falciparum malaria .", + "entities": [] + }, + { + "id": "6598", + "type": "gene", + "text": "LON - 72 ( 34 isolates ) , LON - 73 ( 1 ) , LON - 71 ( 2 ) and LON - 10 ( 2 ) were found at altitudes around 2000 m , 3 of them in a single village .", + "entities": [] + }, + { + "id": "6599", + "type": "gene", + "text": "In this study , we identified Sp1 and Sp3 as major factors binding to the Sp1 sites of the p21 / WAF1 / Cip1 promoter in MG63 cells through electrophoretic mobility shift assays and showed that TSA treatment did not change their binding activities .", + "entities": [ + "Sp1", + "Sp3", + "Sp1 sites", + "p21", + "WAF1", + "Cip1" + ] + }, + { + "id": "6600", + "type": "gene", + "text": "Truncated mammalian Notch1 activates CBF1 / RBPJk - repressed genes by a mechanism resembling that of Epstein - Barr virus EBNA2 .", + "entities": [ + "mammalian Notch1", + "CBF1", + "RBPJk", + "Epstein - Barr virus EBNA2" + ] + }, + { + "id": "6601", + "type": "gene", + "text": "We studied the GR in DMS - 79 cells derived from a human ACTH - secreting small cell lung cancer .", + "entities": [ + "GR", + "ACTH" + ] + }, + { + "id": "6602", + "type": "gene", + "text": "N . van Hoek , and M .", + "entities": [] + }, + { + "id": "6603", + "type": "gene", + "text": "Clones 33F and 34B encoded identical aromatase proteins of 503 amino acids , but differed in size due to alternative polyadenylation signal usage for the corresponding mRNAs .", + "entities": [ + "aromatase proteins" + ] + }, + { + "id": "6604", + "type": "gene", + "text": "Functional tests using a reporter gene , containing Stat5 - binding elements , confirmed that while the variant form was inactive by itself , it could inhibit the function of the full - length receptor .", + "entities": [ + "Stat5 - binding elements" + ] + }, + { + "id": "6605", + "type": "gene", + "text": "The \" tobacco issue \" .", + "entities": [] + }, + { + "id": "6606", + "type": "gene", + "text": "Oncostatin M stimulates c - Fos to bind a transcriptionally responsive AP - 1 element within the tissue inhibitor of metalloproteinase - 1 promoter .", + "entities": [ + "Oncostatin M", + "c - Fos", + "AP - 1 element", + "tissue inhibitor of metalloproteinase - 1 promoter" + ] + }, + { + "id": "6607", + "type": "gene", + "text": "This fragment can bind several trans - acting factors in vitro , including GATA - 1 and members of the Ets family .", + "entities": [ + "GATA - 1", + "Ets family" + ] + }, + { + "id": "6608", + "type": "gene", + "text": "These cognitive deficits were prevented in animals treated with MK - 801 during SE .", + "entities": [] + }, + { + "id": "6609", + "type": "gene", + "text": "Serum gastrin and AFP levels had the same evolution and appear to have the same interest to follow the course of the disease .", + "entities": [ + "gastrin", + "AFP" + ] + }, + { + "id": "6610", + "type": "gene", + "text": "Phenobarbital - induced alterations in the metabolism of [ 3H ] vitamin D3 by the perfused rachitic rat liver in vitro .", + "entities": [] + }, + { + "id": "6611", + "type": "gene", + "text": "Not Available", + "entities": [] + }, + { + "id": "6612", + "type": "gene", + "text": "POU - specific and POU - homeo domains of Oct3 were produced in Echerichia coli for characterization of DNA binding to the octamer sequence .", + "entities": [ + "POU", + "POU", + "Oct3" + ] + }, + { + "id": "6613", + "type": "gene", + "text": "Cytogenetic and molecular characterization of random chromosomal rearrangements activating the drug resistance gene , MDR1 / P - glycoprotein , in drug - selected cell lines and patients with drug refractory ALL .", + "entities": [ + "MDR1", + "P - glycoprotein" + ] + }, + { + "id": "6614", + "type": "gene", + "text": "A narrow zone of myelin - axonal dissociation was also observed .", + "entities": [] + }, + { + "id": "6615", + "type": "gene", + "text": "Our results show that the temperature - sensitive rad54 - 3 allele blocks mitotic recombination between tandemly repeated DYZ3 satellite sequences and significantly stabilizes a human DYZ5 satellite - containing YAC clone .", + "entities": [ + "temperature - sensitive rad54 - 3 allele", + "DYZ3 satellite sequences", + "human DYZ5" + ] + }, + { + "id": "6616", + "type": "gene", + "text": "Insulin stimulation promoted the association of mIRS3 with p85 , SHP2 , Nck , and Shc .", + "entities": [ + "Insulin", + "mIRS3", + "p85", + "SHP2", + "Nck", + "Shc" + ] + }, + { + "id": "6617", + "type": "gene", + "text": "PFK - A mRNA was more abundantly expressed in all tissues than were the PFK - B and PFK - C genes .", + "entities": [ + "PFK - A", + "PFK - B", + "PFK - C genes" + ] + }, + { + "id": "6618", + "type": "gene", + "text": "( 1998 ) FASEB J .", + "entities": [] + }, + { + "id": "6619", + "type": "gene", + "text": "Modification by this latter compound was so extensive that the amount of membrane - associated N - myristoylated protein was decreased .", + "entities": [] + }, + { + "id": "6620", + "type": "gene", + "text": "Amikacin concentrations in serum and blister fluid in healthy volunteers and in patients with renal impairment .", + "entities": [] + }, + { + "id": "6621", + "type": "gene", + "text": "The duration of reactive hyperemia decreased with aging , but the difference between males and females was not significant at any age .", + "entities": [] + }, + { + "id": "6622", + "type": "gene", + "text": "A cDNA encoding a MYC - related DNA binding protein was isolated by DNA - ligand binding screening , using the 67 - bp region as a probe , and designated rd22BP1 .", + "entities": [ + "MYC - related DNA binding protein", + "rd22BP1" + ] + }, + { + "id": "6623", + "type": "gene", + "text": "Ampicillin ( AMP ) alone or with an aminoglycoside ( AMI ) was the treatment in 9 and 16 cases , respectively .", + "entities": [] + }, + { + "id": "6624", + "type": "gene", + "text": "Brain pH following 3 h of cerebral focal ischemia changed from a normal value of 7 . 0 to 6 . 5 and 6 . 2 in animals studied under barbiturate and halothane anesthesia , respectively .", + "entities": [] + }, + { + "id": "6625", + "type": "gene", + "text": "Here we report the full - length coding cDNA sequence of the mouse homologue of MPP3 .", + "entities": [ + "mouse homologue of MPP3" + ] + }, + { + "id": "6626", + "type": "gene", + "text": "Proteomic patterns of nipple aspirate fluids obtained by SELDI - TOF : potential for new biomarkers to aid in the diagnosis of breast cancer .", + "entities": [] + }, + { + "id": "6627", + "type": "gene", + "text": "Exercise training has become increasingly important in the treatment of heart failure patients .", + "entities": [] + }, + { + "id": "6628", + "type": "gene", + "text": "Characterization of FIII / YY1 , a Xenopus laevis conserved zinc - finger protein binding to the first exon of L1 and L14 ribosomal protein genes .", + "entities": [ + "FIII", + "YY1", + "Xenopus laevis conserved zinc - finger protein", + "L1", + "L14 ribosomal protein genes" + ] + }, + { + "id": "6629", + "type": "gene", + "text": "In addition , we also show that cdk7 may phosphorylate the carboxy - terminal domain ( CTD ) of RNA pol II in the absence of promoter opening .", + "entities": [ + "cdk7", + "RNA pol II" + ] + }, + { + "id": "6630", + "type": "gene", + "text": "Sixty days after the intervention , twitch and tetanic tensions remained dependent upon the extracellular Ca2 + concentration ( [ Ca ] o ) both in groups A and B .", + "entities": [] + }, + { + "id": "6631", + "type": "gene", + "text": "Gel - mobility - shift assays confirmed that the Raji nuclear proteins that bound to W and V elements were competed with by an HLA - DRA X - box oligonucleotide .", + "entities": [ + "HLA - DRA X - box oligonucleotide" + ] + }, + { + "id": "6632", + "type": "gene", + "text": "Strategies for blood screening for the hepatitis C virus and for the human immunodeficiency virus in high risk groups .", + "entities": [] + }, + { + "id": "6633", + "type": "gene", + "text": "To understand the basis for the increased cell surface stability compared with wild - type peptide and to understand the differences in T cell recognition between I1Y and I1F , we determined the x - ray crystal structures of the two class I MHC - peptide complexes .", + "entities": [ + "I1Y", + "I1F", + "class I MHC - peptide complexes" + ] + }, + { + "id": "6634", + "type": "gene", + "text": "Variations in the 5 ' half of U3 were primarily due to insertions and deletions .", + "entities": [] + }, + { + "id": "6635", + "type": "gene", + "text": "Study of the energy metabolism of the sensomotor cortex and hippocampus by the ( 14C ) 2 - deoxyglucose method during the development of dissociated states", + "entities": [] + }, + { + "id": "6636", + "type": "gene", + "text": "All patients had the CA 125 assay performed within one week before their second - look operation .", + "entities": [ + "CA 125" + ] + }, + { + "id": "6637", + "type": "gene", + "text": "Manifest anxiety of Vietnam returnees and undergraduates .", + "entities": [] + }, + { + "id": "6638", + "type": "gene", + "text": "Substitution of either Val33 ( by Gly ) or Gly28 ( by Ser ) , two of the most conserved residues in all protein kinases , resulted in enzyme with marginally detectable activity .", + "entities": [] + }, + { + "id": "6639", + "type": "gene", + "text": "Palindromic rheumatism", + "entities": [] + }, + { + "id": "6640", + "type": "gene", + "text": "We report here the discovery of a new actin - related gene in this organism , which we have named ACT4 .", + "entities": [ + "actin - related gene", + "ACT4" + ] + }, + { + "id": "6641", + "type": "gene", + "text": "In girls prolactin levels rise at stage 2 , and are higher after menarche ; in boys there is no change in prolactin levels .", + "entities": [ + "prolactin", + "prolactin" + ] + }, + { + "id": "6642", + "type": "gene", + "text": "However , a specific ICE / caspase - 1 inhibitor called N1445 completely abolished the CK - induced apoptosis by reactivating PKB , but without affecting the CK - induced suppression of Ras transformation .", + "entities": [ + "ICE", + "caspase - 1", + "CK", + "PKB", + "CK", + "Ras" + ] + }, + { + "id": "6643", + "type": "gene", + "text": "272 , 19107 - 19110 ) .", + "entities": [] + }, + { + "id": "6644", + "type": "gene", + "text": "MOP5 contained the characteristic PAS domain and a variable C terminus ; it is possible that the cDNA contains a bHLH domain , but the entire open reading frame has yet to be completed .", + "entities": [ + "MOP5", + "PAS" + ] + }, + { + "id": "6645", + "type": "gene", + "text": "Scaling of fluctuations in one - dimensional interface and hopping models .", + "entities": [] + }, + { + "id": "6646", + "type": "gene", + "text": "We have cloned and characterized a 55 - kb region of DNA surrounding HRAS1 .", + "entities": [ + "HRAS1" + ] + }, + { + "id": "6647", + "type": "gene", + "text": "BACKGROUND : Studies in lean men show poor regulation of energy ( EB ) and fat balance ( FB ) during manipulation of dietary ratios of fat to carbohydrate .", + "entities": [] + }, + { + "id": "6648", + "type": "gene", + "text": "The 5 ' flanking regions of both pelA and pelB were translationally fused to the beta - glucuronidase gene and introduced into F . solani f .", + "entities": [ + "pelA", + "pelB", + "beta - glucuronidase gene" + ] + }, + { + "id": "6649", + "type": "gene", + "text": "sp . pisi , and beta - glucuronidase activities of the transformants were measured .", + "entities": [ + "beta - glucuronidase" + ] + }, + { + "id": "6650", + "type": "gene", + "text": "Eight induced cDNA sequences were identified and designated message up - regulated during death ( mud ) - 1 - 8 .", + "entities": [ + "( mud ) - 1 - 8" + ] + }, + { + "id": "6651", + "type": "gene", + "text": "Our results indicate that periseizure lipid accumulation is related to cortical oxygenation .", + "entities": [] + }, + { + "id": "6652", + "type": "gene", + "text": "In vitro binding studies demonstrate that eIF - 5A is required for efficient interaction of Rev - NES with CRM1 / exportin1 and that eIF - 5A interacts with the nucleoporins CAN / nup214 , nup153 , nup98 , and nup62 .", + "entities": [ + "eIF - 5A", + "Rev", + "NES", + "CRM1", + "exportin1", + "eIF - 5A", + "CAN", + "nup214", + "nup153", + "nup98", + "nup62" + ] + }, + { + "id": "6653", + "type": "gene", + "text": "METHODS AND RESULTS : We prospectively compared the automated measurements of left ventricular ejection fraction ( LVEF ) and volumes from rest - injected gated Technetium 99m ( Tc99m ) perfusion SPECT with equilibrium radionuclide angiocardiography ( ERNA ) in 62 patients and the assessment of regional function with echocardiography in 22 patients .", + "entities": [] + }, + { + "id": "6654", + "type": "gene", + "text": "The effective and low toxic dose schedules of KW - 2083 should be investigated further .", + "entities": [] + }, + { + "id": "6655", + "type": "gene", + "text": "PowerBLAST analysis identified six clusters of expressed sequence tags ( ESTs ) , two known genes ( BIR , SUR1 ) mapped previously to this region , and a previously characterized but unmapped gene NEFA ( DNA binding / EF hand / acidic amino - acid - rich ) .", + "entities": [ + "BIR", + "SUR1", + "gene NEFA", + "DNA binding / EF hand / acidic amino - acid - rich" + ] + }, + { + "id": "6656", + "type": "gene", + "text": "VirD2 is one of the key Agrobacterium tumefaciens proteins involved in T - DNA processing and transfer .", + "entities": [ + "VirD2" + ] + }, + { + "id": "6657", + "type": "gene", + "text": "The history of exposure and carboxyhemoglobin levels should alert the physician to this diagnosis .", + "entities": [ + "carboxyhemoglobin" + ] + }, + { + "id": "6658", + "type": "gene", + "text": "The steepness of the standard O2 dissociation curve becomes greater during the training period ( increase in Hill ' s n from 2 . 68 + / - 0 . 10 to 2 . 96 + / - 0 . 15 ) .", + "entities": [] + }, + { + "id": "6659", + "type": "gene", + "text": "The highest doses were found for drivers who transported large numbers of 99Mo generators .", + "entities": [] + }, + { + "id": "6660", + "type": "gene", + "text": "During the program ' s use at the RSNA meeting , the program selected the correct diagnosis in the top five 22 % of the time .", + "entities": [] + }, + { + "id": "6661", + "type": "gene", + "text": "The two most recent patients ( 35 and 132 days ) received only oral dipyridamole ( 75 mg X 3 / day ) and aspirin ( 80 mg / day ) after the early recovery period ( four - six days ) , resulting in normal prothrombin and partial thromboplastin times .", + "entities": [ + "prothrombin", + "thromboplastin" + ] + }, + { + "id": "6662", + "type": "gene", + "text": "The mitochondrial regulatory region ( mrr ) located between the tRNAPhe and tRNAPro genes of mitochondrial DNA ( mtDNA ) is essential for regulation of replication and transcription of the mitochondrial genome .", + "entities": [ + "mitochondrial regulatory region", + "mrr", + "tRNAPhe", + "tRNAPro genes" + ] + }, + { + "id": "6663", + "type": "gene", + "text": "The exploratory behaviour in normal and aggressive mice .", + "entities": [] + }, + { + "id": "6664", + "type": "gene", + "text": "Taken together , these data suggest that the Mif2 protein interacts with Cep1p at the centromere and that the yeast centromere indeed exists as a higher order protein - DNA complex .", + "entities": [ + "Mif2 protein", + "Cep1p" + ] + }, + { + "id": "6665", + "type": "gene", + "text": "During the biosynthesis of all three mutant polypeptides , the signal peptide is efficiently and accurately cleaved from the nascent protein , even though in mutants X2 and X3 the cleavage site itself has been altered .", + "entities": [] + }, + { + "id": "6666", + "type": "gene", + "text": "Activated PKR may exist as a dimer and phosphorylates the eukaryotic translation initiation factor 2 alpha subunit ( cIF - 2 alpha ) to inhibit polypeptide chain initiation .", + "entities": [ + "PKR", + "eukaryotic translation initiation factor 2 alpha subunit", + "cIF - 2 alpha" + ] + }, + { + "id": "6667", + "type": "gene", + "text": "Testing blood donors for non - A , non - B hepatitis : irrational , perhaps , but inescapable .", + "entities": [] + }, + { + "id": "6668", + "type": "gene", + "text": "The risk factors studied were male sex , hypertension , diabetes mellitus , hypercholesterolemia , cigarette smoking , sedentary life - style , and family history .", + "entities": [] + }, + { + "id": "6669", + "type": "gene", + "text": "Moreover , following a single intravenous injection of the bicistronic vector complexed to cationic liposomes into recipient mice , delivery of MDR1 and GC cDNAs was achieved in all the organs we tested .", + "entities": [ + "MDR1", + "GC cDNAs" + ] + }, + { + "id": "6670", + "type": "gene", + "text": "Three sequence elements are shown to be required for accurate and efficient transcription termination by RNA polymerase I ( pol I ) assayed both in a cell - free transcription system and in vivo after transfection of rDNA minigene constructs into 3T6 cells .", + "entities": [ + "RNA polymerase I", + "pol I" + ] + }, + { + "id": "6671", + "type": "gene", + "text": "Treatment is instituted with prednisone and cyclophosphamide .", + "entities": [] + }, + { + "id": "6672", + "type": "gene", + "text": "An intravenous drip infusion of AMK in adequate dosage would be beneficial to use against some infectious diseases of otorhinolaryngologic field .", + "entities": [] + }, + { + "id": "6673", + "type": "gene", + "text": "Potentially load - insensitive measures of ventricular performance were therefore evaluated in 10 open - and closed - chested , anesthetized rabbits .", + "entities": [] + }, + { + "id": "6674", + "type": "gene", + "text": "CONCLUSIONS : LSCC malformation , like other inner ear malformations such as large vestibular aqueduct and X - linked mixed deafness with perilymph gusher , can be associated with CHL , SNHL , or normal hearing .", + "entities": [] + }, + { + "id": "6675", + "type": "gene", + "text": "The distribution of their fibrinogen levels was Gaussian , but more wide - based than the distribution of our normal controls .", + "entities": [ + "fibrinogen" + ] + }, + { + "id": "6676", + "type": "gene", + "text": "This - 2485 / - 2458 element bound PPARalpha and PPARgamma from brown fat nuclei .", + "entities": [ + "PPARalpha", + "PPARgamma" + ] + }, + { + "id": "6677", + "type": "gene", + "text": "Moreover , the effect exerted by TIS1 appeared to be selective for the MCK promoter .", + "entities": [ + "TIS1", + "MCK promoter" + ] + }, + { + "id": "6678", + "type": "gene", + "text": "The presence of the corresponding mature mRNA transcripts ( 3 . 2 - 3 . 5 kilobase pairs ( kb ] in human fibroblasts was shown by Northern blot hybridization , S1 nuclease protection assay , and the polymerase chain reaction .", + "entities": [ + "S1 nuclease" + ] + }, + { + "id": "6679", + "type": "gene", + "text": "Toluene is the chemical most frequently present in cases involving volatile solvents .", + "entities": [] + }, + { + "id": "6680", + "type": "gene", + "text": "Insulin regulation of mitogen - activated protein kinase kinase ( MEK ) , mitogen - activated protein kinase and casein kinase in the cell nucleus : a possible role in the regulation of gene expression .", + "entities": [ + "Insulin", + "mitogen - activated protein kinase kinase", + "MEK", + "mitogen - activated protein kinase", + "casein kinase" + ] + }, + { + "id": "6681", + "type": "gene", + "text": "Adduction of the human N - ras codon 61 sequence with ( - ) - ( 7S , 8R , 9R , 10S ) - 7 , 8 - dihydroxy - 9 , 10 - epoxy - 7 , 8 , 9 , 10 - tetrahydrobenzo [ a ] pyrene : structural refinement of the intercalated SRSR ( 61 , 2 ) ( - ) - ( 7S , 8R , 9S , 10R ) - N6 - [ 10 - ( 7 , 8 , 9 , 10 - tetrahydrobenzo [ a ] pyrenyl ) ] - 2 ' - deoxyadenosyl adduct from 1H NMR .", + "entities": [ + "human N - ras codon 61 sequence" + ] + }, + { + "id": "6682", + "type": "gene", + "text": "A gas - liquid chromatographic method for the determination of p - chlorophenoxyisobutyric ( CPIB ) acid in blood plasma is described .", + "entities": [] + }, + { + "id": "6683", + "type": "gene", + "text": "As the half - life of the compound did never exceed 8 - 9 h , the data do not support any change of pidotimod administration schedule ( every 24 - 12 h ) .", + "entities": [] + }, + { + "id": "6684", + "type": "gene", + "text": "Src activation induced by FGF1 was blocked by the SH2 domain of Src and PP2 , a specific inhibitor of Src .", + "entities": [ + "Src", + "FGF1", + "SH2 domain", + "Src", + "PP2", + "Src" + ] + }, + { + "id": "6685", + "type": "gene", + "text": "AGO1 is similar to QDE - 2 required for quelling and RDE - 1 required for RNAi .", + "entities": [ + "AGO1", + "QDE - 2", + "RDE - 1" + ] + }, + { + "id": "6686", + "type": "gene", + "text": "( 2 ) Diffusion limitation in the heterogeneous model sets in at a lower O2 requirement value , and increases more gradually with increasing O2 requirement , than in the corresponding homogeneous models with the same average cylinder diameter .", + "entities": [] + }, + { + "id": "6687", + "type": "gene", + "text": "To assess the relationship between G ( q ) / G ( 11 ) function with the phosphatidylinositol 3 - kinase dependent pathway , expression of a dominant - interfering p85 regulatory subunit , as well as wortmannin treatment inhibited insulin - stimulated but not G ( q ) / Q209L - stimulated GLUT4 - EGFP translocation .", + "entities": [ + "G ( q )", + "G ( 11 )", + "phosphatidylinositol 3 - kinase", + "p85 regulatory subunit", + "insulin", + "G ( q ) / Q209L", + "GLUT4", + "EGFP" + ] + }, + { + "id": "6688", + "type": "gene", + "text": "Here , we report the characterization of an alternatively processed form of AFAP - 110 that encodes an additional 258 base pair ( bp ) of open reading frame .", + "entities": [ + "AFAP - 110" + ] + }, + { + "id": "6689", + "type": "gene", + "text": "Incidental findings in the epidermis and in the intraepidermal eccrine sweat duct units .", + "entities": [] + }, + { + "id": "6690", + "type": "gene", + "text": "Recently , the 3 . 6 - kb full - length alpha - GalNAc cDNA sequence was isolated and found to have remarkable nucleotide and predicted amino acid homology ( 55 . 8 and 46 . 9 % , respectively ) with the human alpha - galactosidase A ( alpha - Gal A ) cDNA .", + "entities": [ + "3 . 6 - kb full - length alpha - GalNAc cDNA sequence", + "human alpha - galactosidase A", + "alpha - Gal A" + ] + }, + { + "id": "6691", + "type": "gene", + "text": "This repression was mediated through binding to the E2 DNA - binding site immediately upstream of the P105 promoter TATA box and could be abrogated by preincubation of the HPV - 18 P105 promoter template with the nuclear extract allowing the formation of the preinitiation complex .", + "entities": [ + "E2 DNA - binding site", + "P105", + "HPV - 18 P105 promoter" + ] + }, + { + "id": "6692", + "type": "gene", + "text": "Modulation of 25 - hydroxyvitamin D3 - 24 - hydroxylase by aminophylline : a cytochrome P - 450 monooxygenase system .", + "entities": [ + "25 - hydroxyvitamin D3 - 24 - hydroxylase", + "cytochrome P - 450 monooxygenase" + ] + }, + { + "id": "6693", + "type": "gene", + "text": "One of these factors , IRF - 2 , was initially cloned as an antagonistic counterpart to IRF - 1 with oncogenic potential .", + "entities": [ + "IRF - 2", + "IRF - 1" + ] + }, + { + "id": "6694", + "type": "gene", + "text": "Finally , we determined the genomic organization of the human TrxR2 gene , which consists of 18 exons spanning about 67 kb , and its chromosomal localization at position 22q11 . 2 .", + "entities": [ + "human TrxR2 gene" + ] + }, + { + "id": "6695", + "type": "gene", + "text": "In conclusion , to study and overcome TI region - based expression problems it is worthwhile to start out with a versatile vector containing exhaustive mutations in the periShine - Dalgarno sequences ; as a rule the coding MTI subregion can be kept unchanged .", + "entities": [] + }, + { + "id": "6696", + "type": "gene", + "text": "Electromagnetic blood flow ( BF ) probe was applied on the left anterior descending artery ( LAD ) .", + "entities": [] + }, + { + "id": "6697", + "type": "gene", + "text": "DESIGN : A retrospective chart review of 9 , 322 patients undergoing surgical procedures in the period January 1993 to December 1998 .", + "entities": [] + }, + { + "id": "6698", + "type": "gene", + "text": "This locus maps approximately 160 kbp from the genes encoding cytadherence - associated proteins HMW1 and HMW3 , and yet insertions therein result in loss of these proteins and a hemadsorption - negative ( HA - ) phenotype , prompting the designation cytadherence - regulatory locus ( crl ) .", + "entities": [ + "HMW1", + "HMW3", + "cytadherence - regulatory locus", + "crl" + ] + }, + { + "id": "6699", + "type": "gene", + "text": "Value of determination of alkaline phosphatase isoenzymes for differential diagnosis of obstructive jaundice and biliary liver cirrhosis", + "entities": [ + "alkaline phosphatase isoenzymes" + ] + }, + { + "id": "6700", + "type": "gene", + "text": "There was however , no significant difference in the prevalence of chronic respiratory symptoms between animal food workers with positive and negative skin tests to house dust or to fish flour or among those with increased or normal IgE ( except for dyspnea ) .", + "entities": [ + "IgE" + ] + }, + { + "id": "6701", + "type": "gene", + "text": "The CANNTG motifs were found to bind MyoD and myogenin fusion proteins and to interact with proteins in nuclear extracts from cultured myotubes .", + "entities": [ + "MyoD", + "myogenin fusion proteins" + ] + }, + { + "id": "6702", + "type": "gene", + "text": "The bZP2 cDNA ( 115 - 1914 nt , 1 . 8 kb ) , excluding sequences coding for N - terminal signal sequence and C - terminal transmembranelike domain , was PCR amplified and Sac1 - Sal1 restricted fragment cloned in frame downstream of the T5 promoter under the lac operator control in a pQE - 30 vector .", + "entities": [ + "bZP2 cDNA ( 115 - 1914 nt , 1 . 8 kb )", + "Sac1", + "Sal1", + "lac operator" + ] + }, + { + "id": "6703", + "type": "gene", + "text": "Angiotensin converting enzyme inhibitors enhance the antihypertensive efficacy of diuretics and blunt or prevent adverse metabolic effects .", + "entities": [ + "Angiotensin converting enzyme" + ] + }, + { + "id": "6704", + "type": "gene", + "text": "We have earlier evolved an experimental model by means of which changes identical to the microembolism syndrome can be induced from a reproducible musculo - skeletal trauma in pigs observed under long - term anesthesia under standardized conditions .", + "entities": [] + }, + { + "id": "6705", + "type": "gene", + "text": "By using lambda gt11 expression cloning with oligonucleotides corresponding to the human immunodeficiency virus 1 TATA element , we report the identification of a cellular protein with a calculated molecular mass of 123 kDa that we designate TATA element modulatory factor ( TMF ) .", + "entities": [ + "TATA element modulatory factor", + "TMF" + ] + }, + { + "id": "6706", + "type": "gene", + "text": "Position - independent expression of a human nerve growth factor - luciferase reporter gene cloned on a yeast artificial chromosome vector .", + "entities": [ + "nerve growth factor", + "luciferase" + ] + }, + { + "id": "6707", + "type": "gene", + "text": "Antibodies raised against a bacterially produced beta gal - trk receptor kinase fusion protein recognized a 44 kd phosphoprotein phosphorylated on serine , threonine and tyrosine in extracts of trk - 2h transformed NIH3T3 cells .", + "entities": [ + "beta gal", + "trk", + "trk - 2h" + ] + }, + { + "id": "6708", + "type": "gene", + "text": "Inhibition of the Mek / Erk pathway in Rat1 / ras cells , using the Mek inhibitor , PD98059 , resulted in complete cytoskeletal recovery , indistinguishable from that induced by HR12 .", + "entities": [ + "Mek", + "Erk", + "ras", + "Mek" + ] + }, + { + "id": "6709", + "type": "gene", + "text": "To define transcriptional control elements responsible for muscle - specific expression of the human myoglobin gene , we performed mutational analysis of upstream sequences ( nucleotide positions - 373 to + 7 relative to the transcriptional start site ) linked to a firefly luciferase gene .", + "entities": [ + "human myoglobin gene", + "firefly luciferase gene" + ] + }, + { + "id": "6710", + "type": "gene", + "text": "Determinants of recurrent ischaemia and revascularisation procedures after thrombolysis with recombinant tissue plasminogen activator in primary coronary occlusion .", + "entities": [ + "tissue plasminogen activator" + ] + }, + { + "id": "6711", + "type": "gene", + "text": "The recovery value of systolic pressure was higher than diastolic pressure and pulse pressure increased .", + "entities": [] + }, + { + "id": "6712", + "type": "gene", + "text": "These issues include the use of LMWHs in patients with arterial thrombosis or myocardial infarction ( e . g . in conjunction with thrombolytic treatment ) , and in patients with pulmonary embolism .", + "entities": [] + }, + { + "id": "6713", + "type": "gene", + "text": "In the current study , the roles of two putative cis - acting elements within the - 73 to + 44 region in basal exon 2 promoter activity were evaluated using mutagenesis and nuclear protein - DNA binding assays .", + "entities": [] + }, + { + "id": "6714", + "type": "gene", + "text": "In the ileum , enterotoxin increased the luminal disappearance ( P less than 0 . 05 ) and peripheral blood appearance ( P less than 0 . 001 ) of chloroquine .", + "entities": [] + }, + { + "id": "6715", + "type": "gene", + "text": "The elements responsible for glucocorticoid stimulation of ADH gene transcription appear to reside outside of this region .", + "entities": [ + "ADH gene" + ] + }, + { + "id": "6716", + "type": "gene", + "text": "The mean day of diagnosis of periventricular echodensities was 3 + / - 2 days ( range 1 - 11 days ) , and of cystic PVL 21 + / - 8 days ( range 2 - 47 days ) .", + "entities": [] + }, + { + "id": "6717", + "type": "gene", + "text": "Inactivation of MAP kinases occurs via a specific phosphatase , MKP - 1 .", + "entities": [ + "MAP kinases", + "MKP - 1" + ] + }, + { + "id": "6718", + "type": "gene", + "text": "Development of basophilic leukemia with trisomy 8 and atypical erythroblastosis in a patient with a history of aplastic anemia 22 years earlier", + "entities": [] + }, + { + "id": "6719", + "type": "gene", + "text": "cDNA and structural organization of the gene Pole1 for the mouse DNA polymerase epsilon catalytic subunit .", + "entities": [ + "gene Pole1", + "mouse DNA polymerase epsilon catalytic subunit" + ] + }, + { + "id": "6720", + "type": "gene", + "text": "In addition , anti - phosphotyrosine antibodies immunoprecipitated 80K - H from cell lysates of FGF - stimulated but not from control fibroblasts .", + "entities": [ + "anti - phosphotyrosine antibodies", + "80K - H", + "FGF" + ] + }, + { + "id": "6721", + "type": "gene", + "text": "The results demonstrate that the Glc7 phosphatase and its Gac1 regulatory subunit play positive roles in HSF activation of CUP1 transcription .", + "entities": [ + "Glc7 phosphatase", + "Gac1", + "HSF", + "CUP1" + ] + }, + { + "id": "6722", + "type": "gene", + "text": "The core enzyme is homologous to those of bacteriophages T3 , T7 and SP6 whereas the specificity factor shows similarities with bacterial sigma factors .", + "entities": [ + "core enzyme", + "bacterial sigma factors" + ] + }, + { + "id": "6723", + "type": "gene", + "text": "ZIOS was significantly more sensitive than all subsequent methods , and Ptc , O2 was significantly more sensitive than FEV1 .", + "entities": [] + }, + { + "id": "6724", + "type": "gene", + "text": "The factor which binds to the TR promoter co - sedimented with SV40 chromosomes extracted late in infection .", + "entities": [ + "TR promoter" + ] + }, + { + "id": "6725", + "type": "gene", + "text": "These results with clozapine illustrate that LI is sensitive to antipsychotics which differ in their mode of action and furthermore emphasize the value of LI as a test model for detecting the antipsychotic potential of novel drugs .", + "entities": [] + }, + { + "id": "6726", + "type": "gene", + "text": "Urinary urate excretion , urate clearance , and fractional excretion of urate all increased significantly during water immersion , and decreased in the hour following water immersion .", + "entities": [] + }, + { + "id": "6727", + "type": "gene", + "text": "Growth factors induce the expression of the immediate early gene products MAP kinase phosphatase - 1 ( MKP - 1 ) , c - Fos and c - Jun .", + "entities": [ + "MAP kinase phosphatase - 1", + "MKP - 1", + "c - Fos", + "c - Jun" + ] + }, + { + "id": "6728", + "type": "gene", + "text": "The aims of this study were to determine and rank the frequency of self reported visual disability in daily tasks performed by glaucoma patients ; to examine the interrelation between disabilities using factor analysis ; to study the relation between perceived visual difficulty and a measure of the severity of visual field loss ; to develop a glaucoma specific subgroup of questions ; and examine the validity and reliability of this subgroup of questions .", + "entities": [] + }, + { + "id": "6729", + "type": "gene", + "text": "This report provides further evidence for the riMLF in the control of downgaze , and a synkinesis is postulated for the development of the convergence retraction nystagmus .", + "entities": [] + }, + { + "id": "6730", + "type": "gene", + "text": "Sensing with chemically and biologically modified carbon electrodes .", + "entities": [] + }, + { + "id": "6731", + "type": "gene", + "text": "All ABFI - binding sites , regardless of origin , provided weak UAS function in vivo when examined in test plasmids .", + "entities": [ + "ABFI - binding sites" + ] + }, + { + "id": "6732", + "type": "gene", + "text": "We demonstrate that the protein is a murine homologue of SAF - A which has been shown to bind selectively to MARs and is responsible for the satMa - binding activity in the chromatographic fractions .", + "entities": [ + "murine homologue of SAF - A", + "satMa" + ] + }, + { + "id": "6733", + "type": "gene", + "text": "31 , 1997 , 40 patients had died ( 35 in the ERA - II group and 5 in the ERA - III group ) , for a crude mortality rate of 8 . 0 % .", + "entities": [] + }, + { + "id": "6734", + "type": "gene", + "text": "There was no significant correlation between baseline PC40 methacholine and the maximal fall in Vp30 after either the first ( 12 micrograms ) or the second dose ( 24 micrograms ) of platelet activating factor .", + "entities": [ + "platelet activating factor" + ] + }, + { + "id": "6735", + "type": "gene", + "text": "Retrospective analyses of this death revealed a significant decrease of the left ventricular ( LV ) end - diastolic volume index ( EDVI ) of 21 ml / m2 ( 36 % of normal ) .", + "entities": [] + }, + { + "id": "6736", + "type": "gene", + "text": "The structure of the free SH2 domain has been compared to that of the SH2 complexed with a doubly phosphorylated peptide derived from polyomavirus middle T antigen ( MT ) .", + "entities": [ + "SH2 domain", + "SH2", + "polyomavirus middle T antigen", + "MT" + ] + }, + { + "id": "6737", + "type": "gene", + "text": "METHODS : Millipore ultrafiltration membranes of three different pore sizes were used as model lenticule materials . The nominal membrane pore sizes were 0 . 1 microm , 0 . 45 microm , and 3 microm ; the surface roughness increased in the same order The membranes were coated with a thin layer of collagen I and implanted in a circular pocket of the anterior cornea of adult cats , and were clinically evaluated for the extent of epithelialization and the persistence of epithelial attachment .", + "entities": [ + "collagen I" + ] + }, + { + "id": "6738", + "type": "gene", + "text": "We suggest that the ER lumenal variable domain of gp19K has a specific tertiary structure that is important for binding to the polymorphic alpha 1 and alpha 2 domains of class I heavy ( alpha ) chains .", + "entities": [ + "gp19K", + "class I heavy ( alpha ) chains" + ] + }, + { + "id": "6739", + "type": "gene", + "text": "Whereas p82 expression had no effect on ERK2 activation by p126 , p70 completely abrogated this activity .", + "entities": [ + "p82", + "ERK2", + "p126", + "p70" + ] + }, + { + "id": "6740", + "type": "gene", + "text": "However , despite its relationship to the TR , Rev - Erb bound poorly to TR binding sites .", + "entities": [ + "TR", + "Rev", + "Erb", + "TR binding sites" + ] + }, + { + "id": "6741", + "type": "gene", + "text": "To isolate this gene , a P - 1 artificial chromosome ( PAC ) library was screened with a full length UGT2B7 probe and a clone of approximately 100 kb in length was isolated .", + "entities": [ + "full length UGT2B7" + ] + }, + { + "id": "6742", + "type": "gene", + "text": "\" Let the hundred flowers bloom \" .", + "entities": [] + }, + { + "id": "6743", + "type": "gene", + "text": "Transgenic tobacco plants ( ppa - 1 ) constitutively expressing Escherichia coli pyrophosphatase behind the 35S CaMV promoter accumulate high levels of soluble sugars in their leaves [ 27 ] .", + "entities": [ + "ppa - 1", + "Escherichia coli pyrophosphatase", + "35S CaMV promoter" + ] + }, + { + "id": "6744", + "type": "gene", + "text": "Among the remaining 22 sites , six are in the promoters of known alpha - specific genes and two other sites have an alpha2 - Mcm1 - dependent role in determining the direction of mating type switching .", + "entities": [ + "alpha2", + "Mcm1" + ] + }, + { + "id": "6745", + "type": "gene", + "text": "Cataract extraction in primary glaucoma", + "entities": [] + }, + { + "id": "6746", + "type": "gene", + "text": "Azygos vein abutting the posterior wall of the right main and upper lobe bronchi : a normal CT variant .", + "entities": [] + }, + { + "id": "6747", + "type": "gene", + "text": "In this study , we investigated the molecular mechanisms underlying the inducible expression of the flt - 1 gene during the activation of THP - 1 cells .", + "entities": [ + "flt - 1 gene" + ] + }, + { + "id": "6748", + "type": "gene", + "text": "Moreover , the Rho family protein Cdc42 , a conserved morphogenetic G protein , is also a potent regulator of filamentous growth and FG ( TyA ) : : lacZ expression in S . cerevisiae .", + "entities": [ + "Cdc42", + "morphogenetic G protein", + "FG", + "TyA", + "lacZ" + ] + }, + { + "id": "6749", + "type": "gene", + "text": "In support of a role at the spindle , two - hybrid library screening with HEF1 identifies the human homolog of the G2 / M spindle - regulatory protein Dim1p as a specific interactor with a region of HEF1 encompassed in p55 ( HEF1 ) .", + "entities": [ + "HEF1", + "G2 / M spindle - regulatory protein Dim1p", + "HEF1", + "p55", + "HEF1" + ] + }, + { + "id": "6750", + "type": "gene", + "text": "At visit 5 , the isokinetic test showed impaired muscle function recovery from 23 % to 32 % , while the manual test showed almost full recovery .", + "entities": [] + }, + { + "id": "6751", + "type": "gene", + "text": "We also found that the same males , breeding in different years on the same territories , had significantly larger harems in the years they had familiar neighbors .", + "entities": [] + }, + { + "id": "6752", + "type": "gene", + "text": "Enzyme I of the phosphoenolpyruvate : sugar phosphotransferase system .", + "entities": [ + "Enzyme I", + "phosphoenolpyruvate : sugar phosphotransferase" + ] + }, + { + "id": "6753", + "type": "gene", + "text": "A total of 125 acute leukemia adult patients were autografted with bone marrow ( BM ) purged by mafosfamide ( ASTA Z ) during the period of January 1983 to January 1993 .", + "entities": [] + }, + { + "id": "6754", + "type": "gene", + "text": "The high density of tegumental spines on posterior half of the body and the distribution of type II papillae on dorsal surface are considered to be characteristic of C . armatus .", + "entities": [] + }, + { + "id": "6755", + "type": "gene", + "text": "Logistic regression analysis revealed that physicians were 3 . 6 times more likely to detect thin lesions ( < / = 0 . 75 mm ) compared with nonphysician detectors ( 95 % confidence interval [ 95 % CI ] , 2 . 1 , 6 . 5 ; P = 0 . 0001 ) .", + "entities": [] + }, + { + "id": "6756", + "type": "gene", + "text": "Sp1 ' s role in transactivation of the pgp2 / mdr1b promoter was tested in Drosophila Schneider cells .", + "entities": [ + "Sp1", + "pgp2", + "mdr1b" + ] + }, + { + "id": "6757", + "type": "gene", + "text": "A protocol is elaborated for the preparation and characterization of a quality control material ( QCM ) containing intrinsic concentration of cadmium ( Cd ) ( 0 . 8 microgram / L ) and lead ( Pb ) ( 13 . 4 micrograms / dL ) from bovine blood and an elevated QCM containing Cd ( 5 . 0 micrograms / L ) , mercury ( Hg ) ( 11 . 2 micrograms / L ) , and Pb ( 34 . 5 micrograms / dL ) from bovine blood spiked with aqueous spiking - solutions prepared with salts of Cd , Hg , and Pb .", + "entities": [] + }, + { + "id": "6758", + "type": "gene", + "text": "On histologic examination the cuboidal epithelium of the mucous membrane was found to be changed into columnar epithelium , with uneven distribution of enlarged nuclei in the vacuolized cytoplasm .", + "entities": [] + }, + { + "id": "6759", + "type": "gene", + "text": "High - affinity binding of NF - 1 to PSE - B , but not to PSE - A , was confirmed by competition of DNA - protein interactions by using NF - 1 DNA elements and antibodies .", + "entities": [ + "NF - 1", + "PSE - B", + "PSE - A", + "NF - 1" + ] + }, + { + "id": "6760", + "type": "gene", + "text": "The contribution of skin flow to the changes in 760 - 800 nm absorption was investigated by simultaneous measurement of skin flow by laser flow Doppler and NIR recordings during hot water immersion .", + "entities": [] + }, + { + "id": "6761", + "type": "gene", + "text": "However , no studies have been conducted to further investigate this potentially hazardous effect of lidocaine .", + "entities": [] + }, + { + "id": "6762", + "type": "gene", + "text": "Compensatory renal hypertrophy in parabiotic rats .", + "entities": [] + }, + { + "id": "6763", + "type": "gene", + "text": "We show here that the third SH3 domain binds to Sos , a guanine nucleotide exchange factor for Ras and Rac , both in vitro and in vivo .", + "entities": [ + "SH3 domain", + "Sos", + "guanine nucleotide exchange factor", + "Ras", + "Rac" + ] + }, + { + "id": "6764", + "type": "gene", + "text": "Mechanistically , the presence of the GRR appears to stop further degradation of p50 and to stabilize the molecule .", + "entities": [ + "p50" + ] + }, + { + "id": "6765", + "type": "gene", + "text": "Menstrual - cycle phase did not significantly affect personality variables in either group .", + "entities": [] + }, + { + "id": "6766", + "type": "gene", + "text": "Mutation of the NF - kappaB site in the Mdr1b promoter prevents its induction by TNF - alpha .", + "entities": [ + "NF - kappaB site", + "Mdr1b promoter", + "TNF - alpha" + ] + }, + { + "id": "6767", + "type": "gene", + "text": "Immunofluorescence microscopy and cell fractionation analyses showed that the 110 - kDa protein was exclusively nuclear , whereas the 150 - kDa protein was present in both the cytoplasm and nucleus of human cells .", + "entities": [] + }, + { + "id": "6768", + "type": "gene", + "text": "Method of synthesis of the rheumatoid factor in clinico - immunological studies", + "entities": [ + "rheumatoid factor" + ] + }, + { + "id": "6769", + "type": "gene", + "text": "The FAS promoter was up - regulated by insulin through the proximal insulin response sequence containing an E - box motif at the - 65 - base pair position .", + "entities": [ + "FAS promoter", + "insulin", + "insulin response sequence" + ] + }, + { + "id": "6770", + "type": "gene", + "text": "Deletion of the POR2 gene alone had no detectable phenotype , while yeasts with deletions of both the POR1 and POR2 genes were viable and able to grow on glycerol at 30 degrees C , albeit more slowly than delta por1 single mutants .", + "entities": [ + "POR2 gene", + "POR1", + "POR2 genes", + "delta por1 single mutants" + ] + }, + { + "id": "6771", + "type": "gene", + "text": "The appearance of dyskinetic movement disorders in humans following the chronic use of levodopa or amphetamine may be a manifestation of similarly increased dopamine receptor site sensitivity within the striatum .", + "entities": [ + "dopamine receptor site" + ] + }, + { + "id": "6772", + "type": "gene", + "text": "Similar mechanisms leading to deregulation of Tcf target gene activity are likely to be involved in melanoma and other forms of cancer .", + "entities": [ + "Tcf target gene" + ] + }, + { + "id": "6773", + "type": "gene", + "text": "Muscular pathology", + "entities": [] + }, + { + "id": "6774", + "type": "gene", + "text": "We have identified SWI5 ' s nuclear localization signal ( NLS ) and show that it can confer cell cycle - dependent nuclear entry to a heterologous protein .", + "entities": [ + "SWI5" + ] + }, + { + "id": "6775", + "type": "gene", + "text": "The human immunodeficiency virus type 1 ( HIV - 1 ) preferentially infects CD4 + T lymphocytes and may exist as a latent provirus within these cells for extended periods .", + "entities": [ + "CD4 +" + ] + }, + { + "id": "6776", + "type": "gene", + "text": "One of these , an AACA motif , has been shown to be a negative regulator in non - seed tissues and has a similarity to the barley gibberellin responsive element recognized by MYB - like DNA binding proteins .", + "entities": [ + "MYB - like DNA binding proteins" + ] + }, + { + "id": "6777", + "type": "gene", + "text": "Pregnant rats were exposed to one of the following : ( 1 ) 10 % O2 in N2 or 100 % O2 for 2 days beginning at day 7 , 11 , 14 , or 18 of pregnancy ; ( 2 ) 10 % O2 in N2 or 100 % O2 for 10 h / day beginning at day 7 ; or ( 3 ) 14 - 11 % O2 in N2 continuously beginning at day 14 till day 21 when they were sacrificed .", + "entities": [] + }, + { + "id": "6778", + "type": "gene", + "text": "In reviewing a number of the most intensely studied environmentally inducible promoters it becomes clear that the presence of two cis - acting elements are critical for promoter activity , one of which is the G - box ( CCACGTGG ) .", + "entities": [] + }, + { + "id": "6779", + "type": "gene", + "text": "Cleavage by the intron - encoded enzyme ( I - CreI ) occurs 5 bp and 1 bp 3 ' to the intron insertion site ( in the 3 ' - exon ) in the top ( / ) and bottom ( , ) strands , respectively , resulting in 4 - nt single - stranded overhangs with 3 ' - OH termini .", + "entities": [ + "I - CreI" + ] + }, + { + "id": "6780", + "type": "gene", + "text": "These data suggest that dopaminergic regulation of adrenal zona glomerulosa corticosteroid and renal renin secretion is absent in patients with high spinal cord transections , suggesting that intact neural pathways from the central nervous system are necessary for metoclopramide stimulation of aldosterone and renin secretion in men .", + "entities": [ + "renal renin", + "renin" + ] + }, + { + "id": "6781", + "type": "gene", + "text": "Cattaneo , and J .", + "entities": [] + }, + { + "id": "6782", + "type": "gene", + "text": "BIM 130 .", + "entities": [] + }, + { + "id": "6783", + "type": "gene", + "text": "We found that the relative strengths of the promoters were similar in different contexts .", + "entities": [] + }, + { + "id": "6784", + "type": "gene", + "text": "Isopenicillin N isomerase ( epimerase ) has been purified from Streptomyces clavuligerus , and the amino acid sequence of the N - terminus has been determined .", + "entities": [ + "Isopenicillin N isomerase", + "epimerase" + ] + }, + { + "id": "6785", + "type": "gene", + "text": "On an antithrombin unit basis , CY 216 and CY 222 were equivalent and more potent than UH .", + "entities": [ + "antithrombin" + ] + }, + { + "id": "6786", + "type": "gene", + "text": "This intracellular signaling , known as the unfolded protein response ( UPR ) , is mediated by the cis - acting ER stress response element ( ERSE ) in mammals .", + "entities": [] + }, + { + "id": "6787", + "type": "gene", + "text": "On Day 8 , the CIDR - B was removed and 500 micrograms cloprostenol injected , IM .", + "entities": [] + }, + { + "id": "6788", + "type": "gene", + "text": "The exonic sequence encodes a protein of 495 amino acids that is nearly identical to the previously reported protein sequence of human GPT - 1 .", + "entities": [ + "human GPT - 1" + ] + }, + { + "id": "6789", + "type": "gene", + "text": "BACKGROUND : The effectiveness of monoamine oxidase inhibitors ( MAOIs ) in tricyclic resistant depression has received surprisingly little systematic study .", + "entities": [ + "monoamine oxidase" + ] + }, + { + "id": "6790", + "type": "gene", + "text": "The inspiratory oxygen concentration needed ( FiO2 ) and the Horowitz quotient differed in a highly significant manner beginning on the 1st day after trauma .", + "entities": [] + }, + { + "id": "6791", + "type": "gene", + "text": "No significant differences between the two treatment groups were found , but rapid responders had a smaller mean initial platelet - associated IgG index which returned more rapidly and more permanently to normal than that of slow responders .", + "entities": [ + "platelet - associated IgG" + ] + }, + { + "id": "6792", + "type": "gene", + "text": "Further , we show that this EIA - inducible CBF / cdc2 is related to the CBF which was shown to activate the heat shock protein 70 promoter .", + "entities": [ + "EIA", + "cdc2", + "CBF", + "heat shock protein 70 promoter" + ] + }, + { + "id": "6793", + "type": "gene", + "text": "Vasopressin ( AVP ) , the antidiuretic hormone , is a cyclic nonapeptide that acts through binding to G protein - coupled specific membrane receptors pharmacologically divided into three subtypes ( V1a , V1b , and V2 ) linked to distinct second messengers .", + "entities": [ + "Vasopressin", + "AVP", + "G protein - coupled specific membrane receptors", + "V1a", + "V1b", + "V2" + ] + }, + { + "id": "6794", + "type": "gene", + "text": "In all trials , antigen challenge followed 1 h after the last treatment .", + "entities": [] + }, + { + "id": "6795", + "type": "gene", + "text": "Similarly , we observed synthetic phenotypes between mutations in MIF2 and trans - acting mutations in three known yeast centromere protein genes - CEP1 / CBF1 / CPF1 , NDC10 / CBF2 , and CEP3 / CBF3B .", + "entities": [ + "MIF2", + "CEP1", + "CBF1", + "CPF1", + "NDC10", + "CBF2", + "CEP3", + "CBF3B" + ] + }, + { + "id": "6796", + "type": "gene", + "text": "Some of the mutations obtained do not contain a copy of the Ulysses element at the mutant locus , suggesting that a different transposable element may be responsible for the mutation .", + "entities": [ + "Ulysses element" + ] + }, + { + "id": "6797", + "type": "gene", + "text": "There is growing evidence that mammalian AMP - activated protein kinase ( AMPK ) plays a role in protecting cells from stresses that cause ATP depletion by switching off ATP - consuming biosynthetic pathways .", + "entities": [ + "mammalian AMP - activated protein kinase", + "AMPK" + ] + }, + { + "id": "6798", + "type": "gene", + "text": "Two experiments ( N = 20 each ) were carried out to explore the nature of ERP negativities in a visuospatial memory task and in an auditory spatial memory task , respectively .", + "entities": [] + }, + { + "id": "6799", + "type": "gene", + "text": "Is desensitization ' for ragweed hay fever immunologically specific ?", + "entities": [] + }, + { + "id": "6800", + "type": "gene", + "text": "An ELISA procedure was developed for monitoring the specific IgE response in dogs to Dirofilaria immitis infection .", + "entities": [ + "IgE" + ] + }, + { + "id": "6801", + "type": "gene", + "text": "However , while IL - 1beta and TNF - alpha both induced nuclear binding of the Rel proteins p50 and p65 to an NF - kappaB consensus oligonucleotide in gel shift assays and caused transient degradation of inhibitor of NF - kappaB - alpha ( IkappaB - alpha ) in the cytoplasm of myofibroblasts , only IL - 1beta upregulated PDGF - Ralpha .", + "entities": [ + "IL - 1beta", + "TNF - alpha", + "p50", + "p65", + "NF - kappaB consensus oligonucleotide", + "inhibitor of NF - kappaB - alpha", + "IkappaB - alpha", + "IL - 1beta", + "PDGF - Ralpha" + ] + }, + { + "id": "6802", + "type": "gene", + "text": "The presence of AS - oligo had no further effect on the FSH - mediated activation of the EB * - mTf - CAT construct but reduced cAMP - mediated activation .", + "entities": [ + "FSH", + "mTf", + "CAT" + ] + }, + { + "id": "6803", + "type": "gene", + "text": "There were no significant differences in EF between the two studies , both at rest ( 56 . 0 + / - 13 . 8 % vs 58 . 2 + / - 11 . 7 % , p = NS ) and with exercise ( 51 . 1 + / - 17 . 6 % vs 54 . 3 + / - 17 . 6 % , p = NS ) and a highly significant correlation was shown between the two groups of values ( rest r = 0 . 90 , exercise r = 0 . 93 , p less than 0 . 001 ) .", + "entities": [] + }, + { + "id": "6804", + "type": "gene", + "text": "Here we report the complete 6 - kilobase cDNA sequence coding for a chain of 1775 amino acids , as well as the genomic structure .", + "entities": [] + }, + { + "id": "6805", + "type": "gene", + "text": "A chromosome transmission fidelity ( ctf ) mutant , s138 , of Saccharomyces cerevisiae was identified by its centromere ( CEN ) transcriptional readthrough phenotype , suggesting perturbed kinetochore integrity in vivo .", + "entities": [ + "chromosome transmission fidelity", + "ctf" + ] + }, + { + "id": "6806", + "type": "gene", + "text": "This association appears to be mediated by Src - SH2 domain , because PECAM - 1 can be precipitated by a GST - Src - SH2 affinity matrix .", + "entities": [ + "Src", + "SH2", + "PECAM - 1", + "GST", + "Src", + "SH2" + ] + }, + { + "id": "6807", + "type": "gene", + "text": "Either two or more different sequences can promote cleavage , or a single element exists which is long and diffuse .", + "entities": [] + }, + { + "id": "6808", + "type": "gene", + "text": "Platelet number and life span were determined in the last trimester of pregnancy in 22 women who were delivered of small - for - gestational age ( SGA ) infants and in 21 women with infants having normal birth weights .", + "entities": [] + }, + { + "id": "6809", + "type": "gene", + "text": "The article deals with the diagnosing and correction of reversible ischemia of the intestine .", + "entities": [] + }, + { + "id": "6810", + "type": "gene", + "text": "In assays with purified enzymes , wild - type but not PTPS - S19A was a specific substrate for the cGMP - dependent protein kinase ( cGK ) type I and II .", + "entities": [ + "PTPS", + "S19A", + "cGMP - dependent protein kinase ( cGK ) type I and II" + ] + }, + { + "id": "6811", + "type": "gene", + "text": "HA resulted in decreased ( p less than 0 . 05 ) Tre ( 0 . 4 degrees C ) and HR ( 17 b X min - 1 ) , and increased ( p less than 0 . 05 ) Msw ( 16 g X m - 2 X h - 1 ) during the saline experiments .", + "entities": [] + }, + { + "id": "6812", + "type": "gene", + "text": "In one patient with severe diarrhea the estriol concentration in serum was low until the intestinal function normalised and the estriol concentration went up exactly when the diarrhea stopped .", + "entities": [] + }, + { + "id": "6813", + "type": "gene", + "text": "Preflight , inflight , and postflight exercise response tests were conducted on the astronauts of the second Skylab mission ( Skylab 3 ) as part of an evaluation of physiological adaptation to long - term weightlessness .", + "entities": [] + }, + { + "id": "6814", + "type": "gene", + "text": "When expressed alone in test cells , Atr - I is unable to bind TGF - beta , activin , or bone morphogenetic protein 2 .", + "entities": [ + "Atr - I", + "TGF - beta", + "activin", + "bone morphogenetic protein 2" + ] + }, + { + "id": "6815", + "type": "gene", + "text": "C . elegans KLP - 11 / OSM - 3 / KAP - 1 : orthologs of the sea urchin kinesin - II , and mouse KIF3A / KIFB / KAP3 kinesin complexes .", + "entities": [ + "KLP - 11", + "OSM - 3", + "KAP - 1", + "sea urchin kinesin - II", + "KIF3A", + "KIFB", + "kinesin" + ] + }, + { + "id": "6816", + "type": "gene", + "text": "In contrast , the full mu - opioid agonists fentanyl , morphine , I - methadone and levorphanol produced 50 % fentanyl - appropriate responding at doses only 1 . 3 to 10 . 9 times smaller than those required to decrease response rates by 50 % .", + "entities": [] + }, + { + "id": "6817", + "type": "gene", + "text": "The long terminal repeat ( LTR ) of the human immunodeficiency virus ( HIV ) contains three binding sites for the transcriptional factor Sp1 .", + "entities": [ + "Sp1" + ] + }, + { + "id": "6818", + "type": "gene", + "text": "Effect of enteral nutritional products differing in carbohydrate and fat on indices of carbohydrate and lipid metabolism in patients with NIDDM .", + "entities": [] + }, + { + "id": "6819", + "type": "gene", + "text": "Letter : Perspectives in bone marrow transplantation .", + "entities": [] + }, + { + "id": "6820", + "type": "gene", + "text": "Furthermore , as in the human gene , the 3 ' end of the Cacna1f gene maps within 5 kb of the 5 ' end of the mouse synaptophysin gene in a region orthologous to Xp11 . 23 .", + "entities": [ + "Cacna1f gene", + "mouse synaptophysin gene" + ] + }, + { + "id": "6821", + "type": "gene", + "text": "A secondary spread of an imported methicillin - resistant Staphylococcus aureus strain ( MRSA ) to two other patients occurred within a Danish surgical ward in spite of isolation of a multitraumatized index - patient immediately after arrival from a hospital in the Mediterranean area .", + "entities": [] + }, + { + "id": "6822", + "type": "gene", + "text": "In the SPP2 screening test , a few plates were not seen in both groups .", + "entities": [] + }, + { + "id": "6823", + "type": "gene", + "text": "The co - existence of TE domains within modular PKSs along with physically separated , monofunctional TEs ( TE IIs ) has been reported for a number of modular polyketide and non - ribosomal peptide synthases ( NRPS ) .", + "entities": [ + "TE domains", + "PKSs", + "TEs", + "TE IIs", + "non - ribosomal peptide synthases", + "NRPS" + ] + }, + { + "id": "6824", + "type": "gene", + "text": "Cost - effectiveness of interferon beta - 1b in slowing multiple sclerosis disability progression .", + "entities": [ + "interferon beta - 1b" + ] + }, + { + "id": "6825", + "type": "gene", + "text": "The incidence of early neonatal convulsions for inborn babies was 3 . 0 / 1000 live births .", + "entities": [] + }, + { + "id": "6826", + "type": "gene", + "text": "An immunoperoxidase reaction , PAP method , with the antiserum of Factor VIII as the primary antibody , was carried out in the endometrial biopsies to detect the Factor VIII activity in the endometrial endothelium before and after insertion of LNG - IUD - 20 .", + "entities": [ + "immunoperoxidase", + "PAP", + "Factor VIII", + "Factor VIII" + ] + }, + { + "id": "6827", + "type": "gene", + "text": "HupI showed strong identity to rubredoxin and rubredoxin - like proteins from many other bacteria .", + "entities": [ + "HupI", + "rubredoxin", + "rubredoxin - like proteins" + ] + }, + { + "id": "6828", + "type": "gene", + "text": "In XO males , two her - 1 mRNAs , her - 1a and her - 1b , are transcribed from two separate promoters : P1 , located in the 5 ' - flanking region , and P2 , located in the large second intron .", + "entities": [ + "her - 1 mRNAs", + "her - 1a", + "her - 1b" + ] + }, + { + "id": "6829", + "type": "gene", + "text": "These human IFN - beta - transformed cell populations have acquired a low , constitutive production of human IFN , while replicating at a rate similar to that of untransformed cells and of cells transformed with the control vector carrying a human IFN - beta sequence encoding an inactive , mutated protein .", + "entities": [ + "IFN - beta", + "human IFN", + "human IFN - beta sequence" + ] + }, + { + "id": "6830", + "type": "gene", + "text": "The PC2 protein also shows great similarity to the incomplete NH2 - terminal sequence of the human furin gene product , a putative membrane - inserted receptor - like molecule .", + "entities": [ + "PC2 protein", + "human furin gene product" + ] + }, + { + "id": "6831", + "type": "gene", + "text": "Platelet serotonin ( 5 - HT ) and 5 - HT releasing factor in plasma of migrainous patients .", + "entities": [ + "5 - HT releasing factor" + ] + }, + { + "id": "6832", + "type": "gene", + "text": "Formation of hyphae and chlamydospores by Cryptococcus laurentii .", + "entities": [] + }, + { + "id": "6833", + "type": "gene", + "text": "Through Southern blot analyses of DNA from backcross and cogenic mice , recombinant inbred strains , and somatic cell hybrids , the genetic loci that produce the cyclin B1 - related sequences ( designated loci Cycb1 - rs1 to Cycb1 - rs9 ) were mapped on mouse chromosomes 5 , 1 , 17 , 4 , 14 , 13 , 7 , X , and 8 , respectively .", + "entities": [ + "cyclin B1 - related sequences", + "loci Cycb1 - rs1", + "Cycb1 - rs9" + ] + }, + { + "id": "6834", + "type": "gene", + "text": "Temperature - shift experiments using synchronously grown cells of a delta top1 top2 temperature - sensitive ( ts ) double mutant and its isogenic top2 ts strain show that , whereas mitotic blocks can prevent killing of the top2 ts mutant at a nonpermissive temperature , the same treatments are ineffective in preventing cell death of the delta top1 top2 ts double mutant .", + "entities": [ + "top2 temperature - sensitive ( ts ) double mutant", + "top2", + "top2 ts mutant", + "top2 ts double mutant" + ] + }, + { + "id": "6835", + "type": "gene", + "text": "To facilitate the availability of important new therapeutic agents , the Food and Drug Administration ( FDA ) in the mid - 1970s began assigning therapeutic ratings to investigational new drugs and holding end - of - phase II conferences with drug sponsors .", + "entities": [] + }, + { + "id": "6836", + "type": "gene", + "text": "Mesial temporal sclerosis .", + "entities": [] + }, + { + "id": "6837", + "type": "gene", + "text": "Furthermore , no Shine - Dalgarno sequences are present upstream of the presumed translational start codons .", + "entities": [] + }, + { + "id": "6838", + "type": "gene", + "text": "Pancreaticoduodenal lymph node enlargement , regardless of cause , has been a source of imaging confusion because of its propensity to mimic pancreatic malignancy yet not cause biliary obstruction .", + "entities": [] + }, + { + "id": "6839", + "type": "gene", + "text": "Neuregulin stimulates ErbB2 , ErbB3 , and ErbB4 , members of the ErbB family of receptor tyrosine kinases .", + "entities": [ + "Neuregulin", + "ErbB2", + "ErbB3", + "ErbB4", + "ErbB family", + "receptor tyrosine kinases" + ] + }, + { + "id": "6840", + "type": "gene", + "text": "We characterized cDNA clones specific for the extracellular matrix glycoprotein undulin .", + "entities": [ + "undulin" + ] + }, + { + "id": "6841", + "type": "gene", + "text": "Here we characterize an S . cerevisiae Swi3 homolog ( Swh3 ) and present evidence that it associates in a complex with a Snf2 homolog , Sthl .", + "entities": [ + "S . cerevisiae Swi3 homolog", + "Swh3", + "Snf2 homolog", + "Sthl" + ] + }, + { + "id": "6842", + "type": "gene", + "text": "Using various techniques , we have undertaken a systematic analysis of the natural TATA - less human DNA polymerase beta ( beta - pol ) gene promoter .", + "entities": [ + "human DNA polymerase beta", + "beta - pol" + ] + }, + { + "id": "6843", + "type": "gene", + "text": "In human proliferative cells , the NADP - dependent ME activity is poorly expressed and barely inducible by thyroid hormones .", + "entities": [ + "ME" + ] + }, + { + "id": "6844", + "type": "gene", + "text": "The T - cyt promoter , although of bacterial origin is active in planta and the 30 bp cyt - 1 element is located within a region that is essential for T - cyt promotor activity in leaf , stem and root cells of tobacco plants .", + "entities": [ + "T - cyt promoter", + "30 bp cyt - 1 element", + "T - cyt promotor" + ] + }, + { + "id": "6845", + "type": "gene", + "text": "The development and histostructural organization of intrahepatic biliary ducts were studied on a human embryofetal material 6 to 32 weeks old .", + "entities": [] + }, + { + "id": "6846", + "type": "gene", + "text": "Thus , the effects of father absence under routine conditions in relatively healthy samples may exert no significant effects independent of intervening family stressors or maternal psychopathology .", + "entities": [] + }, + { + "id": "6847", + "type": "gene", + "text": "RESULTS : Plasma AVP responses to osmotic stimulation , and non - osmotic inhibition by drinking , were normal in patients with compulsive water drinking .", + "entities": [ + "Plasma AVP" + ] + }, + { + "id": "6848", + "type": "gene", + "text": "( i ) Complete Grb10 expression from cDNA with an ecdysone - regulated transient expression system stimulated PDGF - BB - , IGF - I , and insulin - but not epidermal growth factor ( EGF ) - induced DNA synthesis in an ecdysone dose - responsive fashion .", + "entities": [ + "Grb10", + "PDGF - BB", + "IGF - I", + "insulin", + "epidermal growth factor", + "EGF" + ] + }, + { + "id": "6849", + "type": "gene", + "text": "These results indicate that the cis - regulatory elements required for developmental control of the HaG3 - A helianthinin gene are located in a 2 . 4 kb upstream region of this gene .", + "entities": [ + "HaG3 - A helianthinin gene" + ] + }, + { + "id": "6850", + "type": "gene", + "text": "This is consistent with a model proposing that SSV was generated by recombination between proviral DNA of a simian sarcoma associated virus and proto - sis and that introns were spliced out subsequently from a fused viral - sis messenger RNA .", + "entities": [ + "proto - sis", + "viral - sis messenger RNA" + ] + }, + { + "id": "6851", + "type": "gene", + "text": "In addition , mutation of the Sp1 site also significantly reduced promoter activity .", + "entities": [ + "Sp1 site" + ] + }, + { + "id": "6852", + "type": "gene", + "text": "Early treatment mechanics of the Class II division 2 malocclusion .", + "entities": [] + }, + { + "id": "6853", + "type": "gene", + "text": "Melatonin and seasonality : filling the gap .", + "entities": [] + }, + { + "id": "6854", + "type": "gene", + "text": "Clinical aspects and therapy", + "entities": [] + }, + { + "id": "6855", + "type": "gene", + "text": "Hemodynamic assessment was obtained before and following administration of digoxin 10 micrograms / kg IV or dopamine , 5 to 12 micrograms / kg / min IV .", + "entities": [] + }, + { + "id": "6856", + "type": "gene", + "text": "Additionally , deletion analysis of the UCP2 promoter - PLAP constructs indicated that the minimal region exhibiting the promoter activity was located between nt - 33 and + 100 , and that a strong enhancer was present within 601 bp of the 5 ' - promoter region .", + "entities": [ + "UCP2", + "PLAP" + ] + }, + { + "id": "6857", + "type": "gene", + "text": "The antilog transformation of pH did not improve the results .", + "entities": [] + }, + { + "id": "6858", + "type": "gene", + "text": "Epitope mapping revealed that these three clones appear to recognize an identical epitope domain present on the C - terminal RNP motif of the U1A protein .", + "entities": [ + "U1A protein" + ] + }, + { + "id": "6859", + "type": "gene", + "text": "Conversely , treatment of human protein - tyrosine phosphatase alpha - overexpressing cells with phenylarsine oxide led to a loss of the constitutive NF - kappa B activity .", + "entities": [ + "human protein - tyrosine phosphatase alpha", + "NF - kappa B" + ] + }, + { + "id": "6860", + "type": "gene", + "text": "Sequence comparison between the translated ORF and a protein database reveal between 26 . 5 and 23 . 4 % aa sequence homology to bacterial transmembrane ( TM ) proteins including those mediating chloramphenicol ( Cm ) and tetracycline ( Tc ) resistance and an arabinose - proton symport protein .", + "entities": [ + "bacterial transmembrane ( TM ) proteins" + ] + }, + { + "id": "6861", + "type": "gene", + "text": "Tightly ordered proteasomal degradation of proteins critical for cell cycle control implies a role of the proteasome in maintaining cell proliferation and cell survival .", + "entities": [] + }, + { + "id": "6862", + "type": "gene", + "text": "Two transcripts of 1 . 6 kb and 5 . 8 kb are 5 ' coterminal and may both encode the novel glycoprotein gene EUS4 .", + "entities": [ + "glycoprotein gene EUS4" + ] + }, + { + "id": "6863", + "type": "gene", + "text": "Characterization of the alpha 4 integrin gene promoter .", + "entities": [ + "alpha 4 integrin gene promoter" + ] + }, + { + "id": "6864", + "type": "gene", + "text": "XII .", + "entities": [] + }, + { + "id": "6865", + "type": "gene", + "text": "Galoyan has summarized the results of his discovery of cardioactive neurohormones .", + "entities": [] + }, + { + "id": "6866", + "type": "gene", + "text": "Interactions between the checkpoint abrogator UCN - 01 and several pharmacological inhibitors of the mitogen - activated protein kinase ( MAPK ) kinase ( MEK ) / MAPK pathway have been examined in a variety of human leukemia cell lines .", + "entities": [ + "mitogen - activated protein kinase ( MAPK ) kinase", + "MEK", + "MAPK" + ] + }, + { + "id": "6867", + "type": "gene", + "text": "A rate - decreasing dose of physostigmine , an acetylcholinesterase inhibitor , was studied in combination with the range of atropine doses .", + "entities": [ + "acetylcholinesterase" + ] + }, + { + "id": "6868", + "type": "gene", + "text": "The C - terminal peptide sequences of the human lymphocyte - specific high mobility group ( HMG ) - box transcription factor TCF - 1 are determined by alternative splice mechanisms affecting the exons VIII to X .", + "entities": [ + "human lymphocyte - specific high mobility group ( HMG ) - box transcription factor TCF - 1" + ] + }, + { + "id": "6869", + "type": "gene", + "text": "An experiment examined the effects of treatment with gonadotrophin releasing hormone ( 100 micrograms GnRH injected 24 h after progestagen sponge removal ) , season of treatment ( autumn v . spring ) , the effect of supplementary feeding with lupin grain ( in autumn only , from 12 days before until 8 days after sponge removal ) on the time of ovulation in 182 mature Merino ewes superovulated with a combination of 400 I . U . pregnant mare serum gonadotrophin ( PMSG ) and 12 mg follicle stimulating hormone ( FSH - P ) .", + "entities": [ + "gonadotrophin releasing hormone", + "GnRH", + "pregnant mare serum gonadotrophin", + "PMSG", + "follicle stimulating hormone", + "FSH - P" + ] + }, + { + "id": "6870", + "type": "gene", + "text": "Therapeutic use of continuous subcutaneous infusion of recombinant human erythropoietin in malnourished predialysis anemic patients with diabetic nephropathy .", + "entities": [ + "recombinant human erythropoietin" + ] + }, + { + "id": "6871", + "type": "gene", + "text": "The objective of this study was to examine the influence of HHCA and other serological factors upon the development of VGS .", + "entities": [] + }, + { + "id": "6872", + "type": "gene", + "text": "In this paper , a comparison between the number and shape of corneal endothelial cells has been performed in 25 patients before and 6 months after PRK .", + "entities": [] + }, + { + "id": "6873", + "type": "gene", + "text": "Serine phosphorylation of STAT3 was only apparent after somatostatin treatment and was abolished by pertussis toxin or PD 98059 , together with the associated increases in proliferation .", + "entities": [ + "STAT3", + "somatostatin", + "pertussis toxin" + ] + }, + { + "id": "6874", + "type": "gene", + "text": "Replacement of the spacer sequence between the two ARMs with a shorter stretch of sequence also reduced RNA binding in vitro .", + "entities": [] + }, + { + "id": "6875", + "type": "gene", + "text": "Similar synergistic activation was observed in the IL - 8 promoter , which also contains both NF - IL6 and NF - kappa B binding sites .", + "entities": [ + "IL - 8 promoter", + "NF - IL6", + "NF - kappa B binding sites" + ] + }, + { + "id": "6876", + "type": "gene", + "text": "Products of immune cells such as transfer factor and lymphokines form the third and possibly most important group of immune - stimulating agents .", + "entities": [ + "transfer factor" + ] + }, + { + "id": "6877", + "type": "gene", + "text": "A short history of dermatology in Lagos , Nigeria .", + "entities": [] + }, + { + "id": "6878", + "type": "gene", + "text": "Thirty seven patients ( amitriptyline n = 16 , moclobemide n = 21 ) completed the six week protocol , which was conducted under double blind conditions .", + "entities": [] + }, + { + "id": "6879", + "type": "gene", + "text": "Thus in this region of the vessel pyridinoline represents the major stabilising crosslink of collagen .", + "entities": [ + "collagen" + ] + }, + { + "id": "6880", + "type": "gene", + "text": "This region does not contain an identifiable TATA element , indicating that transcription of the glutaminase gene is driven by a TATA - less promoter .", + "entities": [ + "glutaminase gene" + ] + }, + { + "id": "6881", + "type": "gene", + "text": "The effect of anticonvulsants on sodium - potassium - activated ATPase , sodium , and potassim in cortex .", + "entities": [ + "sodium - potassium - activated ATPase" + ] + }, + { + "id": "6882", + "type": "gene", + "text": "In order to evaluate the function of the hypothalamic - pituitary - thyroid ( HPT ) - axis in unipolar depression , the authors measured basal 0800h plasma levels of free thyroxine ( FT4 ) , free triiodothyronine ( FT3 ) , and thyroid stimulating hormone ( TSH ) by means of the new , ultrasensitive assays ( TSH - IRMA ) in 69 healthy controls , 62 minor , 101 simple major , and 57 melancholic depressed subjects .", + "entities": [ + "thyroid stimulating hormone", + "TSH" + ] + }, + { + "id": "6883", + "type": "gene", + "text": "Plasma histaminase in patients of bronchial asthma and the effect of prednisolone administration on it .", + "entities": [ + "Plasma histaminase" + ] + }, + { + "id": "6884", + "type": "gene", + "text": "Strain CFN037 is an R . etli mutant induced by a single Tn5mob insertion in the promoter region of the thiCOGE gene cluster .", + "entities": [ + "Tn5mob", + "thiCOGE gene cluster" + ] + }, + { + "id": "6885", + "type": "gene", + "text": "Analysis of intron / exon boundaries of the genomic BAC clones demonstrate that junctin , junctate , and aspartyl beta - hydroxylase result from alternative splicing of the same gene .", + "entities": [ + "junctin", + "junctate", + "aspartyl beta - hydroxylase" + ] + }, + { + "id": "6886", + "type": "gene", + "text": "The maximum period of treatment was 73 ( oral ) , 73 ( intraperitoneal ) or 75 ( dermal ) weeks .", + "entities": [] + }, + { + "id": "6887", + "type": "gene", + "text": "3 Significant reductions in lying mean arterial blood pressure were observed with daily doses of 200 mg ( - 9 % ) , 400 mg ( - 10 % ) and 800 mg ( - 14 % ) , and were associated with significant decreases in heart rate and plasma renin activity .", + "entities": [ + "plasma renin" + ] + }, + { + "id": "6888", + "type": "gene", + "text": "A semiautomatic digital system ( Videoplan 2 ) was used .", + "entities": [] + }, + { + "id": "6889", + "type": "gene", + "text": "No TATA or Inr sequence was found .", + "entities": [] + }, + { + "id": "6890", + "type": "gene", + "text": "We found that virulent Ngo strains induce phosphorylation and activation of JNK but not of p38 kinase .", + "entities": [ + "JNK", + "p38" + ] + }, + { + "id": "6891", + "type": "gene", + "text": "Mis3 is needed for the formation of 18S ribosome RNA , and may hence direct the level of proteins required for the coupling .", + "entities": [ + "Mis3", + "18S ribosome RNA" + ] + }, + { + "id": "6892", + "type": "gene", + "text": "The possible mechanisms underlying differences in post - tetanic effects from muscle and cutaneous afferents in adults and neonates are discussed .", + "entities": [] + }, + { + "id": "6893", + "type": "gene", + "text": "Who says ' National Health Dis - service ' .", + "entities": [] + }, + { + "id": "6894", + "type": "gene", + "text": "Bronchial mucosa tattooing in persons exposed to different industrial aerosols did not depend on the forms of PC , DB and the diseases ' stages .", + "entities": [] + }, + { + "id": "6895", + "type": "gene", + "text": "A new intron of 476 base pairs was found in the middle of the 5 ' - untranslated leader sequence and was shown to robustly enhance the promoter activity .", + "entities": [] + }, + { + "id": "6896", + "type": "gene", + "text": "Indeed , significant level of CAT activity was observed in human lung adenocarcinoma ( A549 - 1 ) cells which had been incubated with a complex of T7 RNA polymerase , pT7 - EMC - CAT DNA and DC - chol cationic liposomes .", + "entities": [ + "CAT", + "T7 RNA polymerase", + "pT7 - EMC - CAT DNA" + ] + }, + { + "id": "6897", + "type": "gene", + "text": "Spfkh1 is transcribed in one open reading frame that contains the DNA binding domain , nuclear localization signal and transactivation domain .", + "entities": [ + "Spfkh1" + ] + }, + { + "id": "6898", + "type": "gene", + "text": "Both methods were employed for various focal - film distances , image intensifier tube modes and laser printer formats .", + "entities": [] + }, + { + "id": "6899", + "type": "gene", + "text": "We also examined the effect of proteolytic processing in the MVE nonstructural polyprotein segment mediated by the viral proteinase NS3 on antigen processing and presentation of the MVE H - 2Kk - restricted T cell determinant .", + "entities": [ + "viral proteinase NS3" + ] + }, + { + "id": "6900", + "type": "gene", + "text": "These data do not support the use of LDD to reduce risk of progression to MSOF in sepsis .", + "entities": [] + }, + { + "id": "6901", + "type": "gene", + "text": "Renal cell carcinoma in children : a single institution ' s experience .", + "entities": [] + }, + { + "id": "6902", + "type": "gene", + "text": "This suggests that cardiovascular magnetic resonance is the preferred technique for volume and ejection fraction estimation in heart failure patients , because of its 3D approach for non - symmetric ventricles and superior image quality .", + "entities": [] + }, + { + "id": "6903", + "type": "gene", + "text": "RA - treatment of these transfectants induced morphologic and immunophenotypic maturation , changes in RA - regulated genes , and a G1 cell cycle arrest in a manner similar to parental NT2 / D1 cells .", + "entities": [] + }, + { + "id": "6904", + "type": "gene", + "text": "One defective RNA with a large deletion in the p70 coding region was able to replicate efficiently , both when inoculated with the helper genome and when inoculated with a second complementing defective RNA that supplied a wild - type p70 .", + "entities": [ + "p70 coding region", + "wild - type p70" + ] + }, + { + "id": "6905", + "type": "gene", + "text": "Dynamic and static scintigrams , using 99mtechnetium methylene diphosphonate , were obtained at zero , six , and 12 weeks after fracture .", + "entities": [] + }, + { + "id": "6906", + "type": "gene", + "text": "Perceptual learning for a pattern discrimination task .", + "entities": [] + }, + { + "id": "6907", + "type": "gene", + "text": "Northern blot analyses show that the hBub1 mRNA level is abundantly expressed in tissues or cells with a high mitotic index .", + "entities": [ + "hBub1 mRNA" + ] + }, + { + "id": "6908", + "type": "gene", + "text": "Alternative splicing of the cytoplasmic tail appears to generate multiple PECAM - 1 isoforms that may regulate phosphorylation , cytoskeletal association , and affinity modulation of the mature protein .", + "entities": [ + "PECAM - 1 isoforms" + ] + }, + { + "id": "6909", + "type": "gene", + "text": "Clear and evidenced - based information should be provided to patients as to the means of prevention with special attention to individual risk groups such as IV drug abusers .", + "entities": [] + }, + { + "id": "6910", + "type": "gene", + "text": "Activation of the mitogen activated protein ( MAP ) kinase is a primary consequence of Ras activation and plays a key role in mediating Ras signal transduction .", + "entities": [ + "mitogen activated protein ( MAP ) kinase", + "Ras", + "Ras" + ] + }, + { + "id": "6911", + "type": "gene", + "text": "Using site - directed mutagenesis , we show that the RAREoct contributes to the transcriptional activation of Oct - 3 / 4 promoter in P19 cells and , most interestingly , mediates the RA - induced repression in RA - differentiated EC cells .", + "entities": [ + "RAREoct", + "Oct - 3 / 4 promoter" + ] + }, + { + "id": "6912", + "type": "gene", + "text": "In addition , narZ expression was induced approximately 20 - fold intracellularly in Madin - Darby canine kidney epithelial cells and 16 - fold in intracellular salts medium , which is believed to mimic the intracellular milieu .", + "entities": [ + "narZ" + ] + }, + { + "id": "6913", + "type": "gene", + "text": "Surprisingly , however , TCR - mediated tyrosine phosphorylation of phospholipase C gamma 1 remains intact in the Jurkat cells expressing the A2 / HCP chimera .", + "entities": [ + "TCR", + "phospholipase C gamma 1", + "A2", + "HCP" + ] + }, + { + "id": "6914", + "type": "gene", + "text": "In addition , mapping of the promoter region and the identification of putative promoter regulatory sequences should give insight into the transcriptional regulation of UCP2 expression - - in particular by anyone of the above mentioned factors - - in vitro and in vivo .", + "entities": [ + "UCP2" + ] + }, + { + "id": "6915", + "type": "gene", + "text": "The sequence has a 1092 - bp open reading frame encoding a protein of 364 amino acids .", + "entities": [] + }, + { + "id": "6916", + "type": "gene", + "text": "The subjects received a single 500 mg dose of acetaminophen i . v . and concentrations in plasma were measured for 360 minutes and in urine for 24 h in order to estimate the production of metabolites .", + "entities": [] + }, + { + "id": "6917", + "type": "gene", + "text": "Two siblings with hemolytic anemia caused by triosephosphate isomerase deficiency developed a progressive neurological syndrome featuring dystonic movements , tremor , pyramidal tract signs , and evidence of spinal motor neuron involvement .", + "entities": [ + "triosephosphate isomerase" + ] + }, + { + "id": "6918", + "type": "gene", + "text": "An inverted Alu repeat element , flanked by nonamer direct repeats , was identified within the region - 913 / - 620 , relative to the cap site .", + "entities": [ + "Alu" + ] + }, + { + "id": "6919", + "type": "gene", + "text": "Enoxacin appears to be well suited for the treatment of complicated UTI .", + "entities": [] + }, + { + "id": "6920", + "type": "gene", + "text": "In this study , the effect of acute administration of various doses of malathion via oral and dermal routes to mice and rats on serum levels of histamine was evaluated .", + "entities": [] + }, + { + "id": "6921", + "type": "gene", + "text": "When a plateau of enhancement was reached , a single lesion in each patient was imaged using five different continuous scanning modes , fundamental grey scale ( FGS ) ; fundamental colour Doppler ( FCD ) ; fundamental power Doppler ( FPD ) ; second harmonic grey scale ( HGS ) ; and pulse inversion mode ( Pim ) using an HDI5000 scanner and C5 - 2 probe ( ATL , Bothell , WA ) .", + "entities": [] + }, + { + "id": "6922", + "type": "gene", + "text": "Varicella - zoster virus ( VZV ) glycoprotein gI is a type 1 transmembrane glycoprotein which is one component of the heterodimeric gE : gI Fc receptor complex .", + "entities": [ + "Varicella - zoster virus ( VZV ) glycoprotein gI", + "type 1 transmembrane glycoprotein", + "gE", + "gI Fc receptor" + ] + }, + { + "id": "6923", + "type": "gene", + "text": "A genomic clone for the cyc07 gene , which is expressed specifically at the S phase during the cell cycle in synchronous cultures of periwinkle ( Catharanthus roseus ) cells , was isolated .", + "entities": [ + "cyc07 gene" + ] + }, + { + "id": "6924", + "type": "gene", + "text": "3 .", + "entities": [] + }, + { + "id": "6925", + "type": "gene", + "text": "NO metabolites were determined by the measurement of nitrate / nitrite ( NOx , micromol / mmol creatinine ) and cyclic guanosine monophosphate ( cGMP , nmol / mmol creatinine ) in plasma and urine .", + "entities": [] + }, + { + "id": "6926", + "type": "gene", + "text": "In this study the splenectomized captive born cynomolgus appeared to be capable of supplementing rhesus as an antimalarial drug testing model .", + "entities": [] + }, + { + "id": "6927", + "type": "gene", + "text": "Disruption of re - replication control by overexpression of human ORC1 in fission yeast .", + "entities": [ + "human ORC1" + ] + }, + { + "id": "6928", + "type": "gene", + "text": "Since high levels of immunoglobulin G were demonstrated against the surface of the NVS after immunization , passive transfer experiments were initiated .", + "entities": [ + "immunoglobulin G" + ] + }, + { + "id": "6929", + "type": "gene", + "text": "A case report with angiographic follow - up study .", + "entities": [] + }, + { + "id": "6930", + "type": "gene", + "text": "Polypeptides of the same apparent sizes are detected in spores of a cotE null mutant , on which basis we infer that the products of the cotJ operon are required for the normal formation of the inner layers of the coat or are themselves structural components of the coat .", + "entities": [ + "cotE", + "cotJ operon" + ] + }, + { + "id": "6931", + "type": "gene", + "text": "We find that 3T1 - 3T2 mixing has a pronounced effect on the line shape and radiative decay rate of emission from the 3T2 state and that the extent of mixing depends critically on the magnitude of nontetrahedral distortions .", + "entities": [] + }, + { + "id": "6932", + "type": "gene", + "text": "Moreover , Western blots demonstrated at least six types of Ypt in both Cr and Vc , suggesting that these Ypt are used for household functions responsible for vesicle transport rather than for cellular differentiation .", + "entities": [ + "Ypt", + "Ypt" + ] + }, + { + "id": "6933", + "type": "gene", + "text": "Alternatively , the similarity in apparent regulatory action of the genes may indicate allelic differences wherein the IS1112C Rf3 allele may differ from alleles of maintainer lines by the capability to regulate both orf107 and urf209 processing activities .", + "entities": [ + "Rf3 allele", + "orf107", + "urf209" + ] + }, + { + "id": "6934", + "type": "gene", + "text": "The LAMMER protein kinase encoded by the Doa locus of Drosophila is required in both somatic and germline cells and is expressed as both nuclear and cytoplasmic isoforms throughout development .", + "entities": [ + "LAMMER", + "Doa locus" + ] + }, + { + "id": "6935", + "type": "gene", + "text": "This cohort of patients was selected on the basis of clinical stage .", + "entities": [] + }, + { + "id": "6936", + "type": "gene", + "text": "Polyadenylation of B4 RNA , which occurs very early during maturation , is limited to 150 residues , and it is this number that is required for polysomal recruitment .", + "entities": [ + "B4 RNA" + ] + }, + { + "id": "6937", + "type": "gene", + "text": "The results indicate considerable flexibility in the spacing between DH regulatory sites .", + "entities": [ + "DH" + ] + }, + { + "id": "6938", + "type": "gene", + "text": "We also recovered mutations in the 60A gene which encodes another TGF - beta - related factor in Drosophila .", + "entities": [ + "60A gene", + "TGF - beta - related factor" + ] + }, + { + "id": "6939", + "type": "gene", + "text": "The standard dosage of anti - D currently given at all gestational ages is 1 ampoule containing 125 micrograms of anti - D .", + "entities": [ + "anti - D", + "anti - D" + ] + }, + { + "id": "6940", + "type": "gene", + "text": "The transcriptional unit spans a chromosomal region of about 55 kilobase pairs ( kbp ) .", + "entities": [] + }, + { + "id": "6941", + "type": "gene", + "text": "The CRE , 5 ' - TGACGTCA - 3 ' , has been described as the consensus sequence for the cis - element that directs cAMP - regulated gene expression .", + "entities": [] + }, + { + "id": "6942", + "type": "gene", + "text": "Beyond the Tower of Babel : a nomenclature for suicidology .", + "entities": [] + }, + { + "id": "6943", + "type": "gene", + "text": "1 A colonic delivery system is described to deliver orally ingested drugs to the colon and release them at that site by coating with an acrylic based resin ( Eudragit S ) .", + "entities": [] + }, + { + "id": "6944", + "type": "gene", + "text": "Keeping in mind the limited range of age and dosages , advantages and disadvantages of the drug are discussed , comparing the experimental results with those derived from the literature .", + "entities": [] + }, + { + "id": "6945", + "type": "gene", + "text": "Transcription factor binding sites downstream of the human immunodeficiency virus type 1 transcription start site are important for virus infectivity .", + "entities": [] + }, + { + "id": "6946", + "type": "gene", + "text": "We also reported the identification of three corresponding alternative first exons and an intronic promoter in the human PDE5A gene .", + "entities": [ + "human PDE5A gene" + ] + }, + { + "id": "6947", + "type": "gene", + "text": "Corneal scrapping and deep stromal biopsy were obtained and stained for microscopic evaluation with periodic acid - Schiff , Giemsa , and Gomori ' s methenamine silver stains .", + "entities": [] + }, + { + "id": "6948", + "type": "gene", + "text": "Identification of p40x - responsive regulatory sequences within the human T - cell leukemia virus type I long terminal repeat .", + "entities": [] + }, + { + "id": "6949", + "type": "gene", + "text": "Peptide sequences of the zinc finger protein Ttk and the transcription factor Adf - 1 were obtained .", + "entities": [ + "zinc finger protein Ttk", + "transcription factor Adf - 1" + ] + }, + { + "id": "6950", + "type": "gene", + "text": "The Ras - related GTPases are small , 20 - to 25 - kDa proteins which cycle between an inactive GDP - bound form and an active GTP - bound state .", + "entities": [ + "Ras - related GTPases" + ] + }, + { + "id": "6951", + "type": "gene", + "text": "An analysis of the steady state RNA levels in T - lymphoid cell lines showed that at least three different incomplete proviral transcripts and their spliced products made up the majority of expressed RD - 114 mRNA , and further demonstrated that partially deleted proviral loci have the potential to be transcriptionally vigorous in certain feline cell types .", + "entities": [ + "RD - 114 mRNA" + ] + }, + { + "id": "6952", + "type": "gene", + "text": "Demyelinating diseases involving the grey matter were very rare , but we must consider the presence of symmetrical thalamic involvement in patients with ADEM .", + "entities": [] + }, + { + "id": "6953", + "type": "gene", + "text": "Three - dimensional structural studies using electron cryomicroscopy showed that the binding of one Fab ( 8H2 / G5 ) does not affect the conformation of the capsid , and the efficiency of mRNA production is similar to that of the native subviral particle .", + "entities": [ + "Fab" + ] + }, + { + "id": "6954", + "type": "gene", + "text": "Taken together , our data suggest that PecS attenuates pelD and pelE expression rather than acting as a true repressor like KdgR .", + "entities": [ + "PecS", + "pelD", + "pelE", + "KdgR" + ] + }, + { + "id": "6955", + "type": "gene", + "text": "PATIENTS AND METHODS : Between January 1992 and June 1994 at St .", + "entities": [] + }, + { + "id": "6956", + "type": "gene", + "text": "The overall prevalence of HBV markers was higher among staff members than in the blood donors of our area .", + "entities": [] + }, + { + "id": "6957", + "type": "gene", + "text": "In several studies the RDFS has shown evidence of reliability and validity .", + "entities": [] + }, + { + "id": "6958", + "type": "gene", + "text": "The sensitivity of human neuroblastoma cells SK - N - SH to undergo apoptosis induced by thapsigargin was examined .", + "entities": [] + }, + { + "id": "6959", + "type": "gene", + "text": "Here we demonstrate that another cellular protein linked to BCR / ABL through the CRKL - SH2 domain is p130 ( CAS ) .", + "entities": [ + "BCR", + "ABL", + "CRKL", + "SH2", + "p130", + "CAS" + ] + }, + { + "id": "6960", + "type": "gene", + "text": "p130 ( CAS ) was found to be tyrosine phosphorylated and associated with CRKL in BCR / ABL expressing cell lines and in samples obtained from CML and ALL patients , but not in samples from controls .", + "entities": [ + "p130", + "CAS", + "CRKL", + "BCR", + "ABL" + ] + }, + { + "id": "6961", + "type": "gene", + "text": "Immunological and biochemical characterization of streptococcal pyrogenic exotoxins I and J ( SPE - I and SPE - J ) from Streptococcus pyogenes .", + "entities": [ + "streptococcal pyrogenic exotoxins I and J", + "SPE - I", + "SPE - J" + ] + }, + { + "id": "6962", + "type": "gene", + "text": "A number of serological tests measuring the presence of Helicobacter pylori - specific serum immunoglobulin G ( IgG ) are now commercially available .", + "entities": [ + "immunoglobulin G", + "IgG" + ] + }, + { + "id": "6963", + "type": "gene", + "text": "Slowed lysosomal enzyme release and its normalization by drugs in adjuvant - induced polyarthritis .", + "entities": [ + "lysosomal enzyme" + ] + }, + { + "id": "6964", + "type": "gene", + "text": "Among the total CDSs , 8 . 8 % match sequences of proteins found only in Bacillus subtilis and 66 . 7 % are widely conserved in comparison with the proteins of various organisms , including B . subtilis .", + "entities": [] + }, + { + "id": "6965", + "type": "gene", + "text": "The cDNA clone was used as a homologous probe to isolate a truncated genomic clone encoding H2A1 .", + "entities": [ + "H2A1" + ] + }, + { + "id": "6966", + "type": "gene", + "text": "CONCLUSION : In women who want or require conservative management of grade 4 prolapse and are unable to retain a single pessary , the placement of two pessaries often will be successful .", + "entities": [] + }, + { + "id": "6967", + "type": "gene", + "text": "Furthermore , Zelen ' s method is used to balance the number of patients allocated to the two groups within each institution ( M .", + "entities": [] + }, + { + "id": "6968", + "type": "gene", + "text": "This alternatively spliced transcript contained an open reading frame extending from the upstream J alpha 11 - 2 region to 82 nucleotides downstream of the beginning of the TCR C alpha region , and potentially encoded a 36 amino acid polypeptide .", + "entities": [ + "TCR C alpha region" + ] + }, + { + "id": "6969", + "type": "gene", + "text": "The cis - acting element mediating glucocorticoid inducibility of the chicken glutamine synthetase gene has been identified .", + "entities": [ + "chicken glutamine synthetase gene" + ] + }, + { + "id": "6970", + "type": "gene", + "text": "TREB7 and TREB36 protected all three repeats of the 21 bp , but TREB5 protected only the second repeat .", + "entities": [ + "TREB7", + "TREB36", + "TREB5" + ] + }, + { + "id": "6971", + "type": "gene", + "text": "Although the expression of the 4E - BP1 gene alone has not yet been accomplished , the gene was expressed in Escherichia coli [ BL21 ( DE3 ) ] as a fusion gene with the glutathione - S - transferase ( GST ) gene using a prokaryotic gene fusion vector ( pGEX - 4T - 2 ) , which contains a gene sequence coding the cleavage site for a specific protease , alpha - thrombin .", + "entities": [ + "4E - BP1 gene", + "glutathione - S - transferase", + "GST", + "alpha - thrombin" + ] + }, + { + "id": "6972", + "type": "gene", + "text": "Immunofluorescence microscopy revealed extensive deposition of such extracellular matrices as type IV collagen and laminin in the vascular wall .", + "entities": [ + "type IV collagen", + "laminin" + ] + }, + { + "id": "6973", + "type": "gene", + "text": "Absorption of electrolytes from the colon in cases of ulcerative colitis and in control subjects .", + "entities": [] + }, + { + "id": "6974", + "type": "gene", + "text": "Transfecting the cloned bovine PBR / IBP cDNA into COS - 7 cells resulted in an 11 - fold increase in the density of high affinity [ 3H ] PK 11195 binding sites which had only low affinity for Ro5 - 4864 .", + "entities": [ + "PBR", + "IBP" + ] + }, + { + "id": "6975", + "type": "gene", + "text": "It was also found that there is no significant difference between the prevalence of nasal carriage of S . aureus amongst the hospital staff and the patients .", + "entities": [] + }, + { + "id": "6976", + "type": "gene", + "text": "We found that TCR signaling induces AP - 1 binding to this site and regulates the fasl promoter function in a fashion dependent on NF - kappaB binding .", + "entities": [ + "TCR", + "AP - 1", + "fasl promoter", + "NF - kappaB" + ] + }, + { + "id": "6977", + "type": "gene", + "text": "The decrease in HDL - cholesterol with increasing VLDL - triglycerides was relatively much larger than the concomitant decrease in apo A - I .", + "entities": [ + "HDL - cholesterol", + "VLDL - triglycerides", + "apo A - I" + ] + }, + { + "id": "6978", + "type": "gene", + "text": "To define the number and nature of the E6 and E7 gene products expressed in BPV - 1 - transformed cells , we performed immunoprecipitation experiments with antisera raised to bacterially expressed BPV - 1 E6 and E7 fusion proteins .", + "entities": [ + "E6", + "E7 gene", + "BPV - 1 E6", + "E7 fusion proteins" + ] + }, + { + "id": "6979", + "type": "gene", + "text": "Promoter region of the transcriptional unit for human alpha 1 - chimaerin , a neuron - specific GTPase - activating protein for p21rac . alpha 1 - chimaerin is a neuron - specific GTPase - activating protein for p21rac , a protein involved in morphological events .", + "entities": [ + "human alpha 1 - chimaerin", + "neuron - specific GTPase - activating protein", + "p21rac", + "alpha 1 - chimaerin", + "neuron - specific GTPase - activating protein", + "p21rac" + ] + }, + { + "id": "6980", + "type": "gene", + "text": "We propose that Mad and Medea encode rate - limiting components integral to dpp pathways throughout development .", + "entities": [ + "Mad", + "Medea", + "dpp" + ] + }, + { + "id": "6981", + "type": "gene", + "text": "Taken together , our results indicate that thrombin - stimulated vascular smooth muscle proliferation is delayed and requires the de novo expression of one or more autocrine mitogens .", + "entities": [ + "thrombin" + ] + }, + { + "id": "6982", + "type": "gene", + "text": "Interventions aimed at these specific mediators and processes may be successful in reducing the very significant human and economic costs of vascular access dysfunction .", + "entities": [] + }, + { + "id": "6983", + "type": "gene", + "text": "An even greater inflammatory response was observed after intratracheal instillation of ufCB , but not after CB instillation .", + "entities": [] + }, + { + "id": "6984", + "type": "gene", + "text": "Using either a p50 - or p65 - selected kappa B motif , which displayed differential binding with respect to the other protein , little to no binding was observed with the heterodimeric NF - kappa B complex .", + "entities": [ + "p50", + "p65 - selected kappa B motif", + "heterodimeric NF - kappa B complex" + ] + }, + { + "id": "6985", + "type": "gene", + "text": "Poliomyelitis from a vaccine .", + "entities": [] + }, + { + "id": "6986", + "type": "gene", + "text": "The other model was a continuous exponential plus constant of the form La - = a + b [ exp ( cVO2 ) ] .", + "entities": [] + }, + { + "id": "6987", + "type": "gene", + "text": "DESIGN : Retrospective study .", + "entities": [] + }, + { + "id": "6988", + "type": "gene", + "text": "Interaction of H - 2Eb with an IAP retrotransposon in the A20 / 2J B cell lymphoma .", + "entities": [ + "H - 2Eb", + "IAP retrotransposon" + ] + }, + { + "id": "6989", + "type": "gene", + "text": "Improved methods have been developed for maintaining and breeding the neotropical short - tailed fruit bat , Carollia perspicillata , in an easily - reproduced , laboratory setting .", + "entities": [] + }, + { + "id": "6990", + "type": "gene", + "text": "In only two patients were we able to demonstrate changes suggestive of pulmonary metastases any earlier with a 99mTc - EHDP scan than with chest radiographs and one of these resolved spontaneously .", + "entities": [] + }, + { + "id": "6991", + "type": "gene", + "text": "In this study , we further investigated the regulation of the synthesis of the c - mos oncogene product , which is necessary for the activation of Cdc2 .", + "entities": [ + "c - mos oncogene product", + "Cdc2" + ] + }, + { + "id": "6992", + "type": "gene", + "text": "The kinase inhibitor staurosporine ( 1 microM ) blocks LPA - induced , but not epidermal growth factor - induced , activation of p21ras and MAP kinase , consistent with an intermediate protein kinase linking the LPA receptor to p21ras activation .", + "entities": [ + "p21ras", + "MAP kinase", + "LPA receptor", + "p21ras" + ] + }, + { + "id": "6993", + "type": "gene", + "text": "The final screening yielded a clone containing a 2 kilobase ( kb ) insert .", + "entities": [] + }, + { + "id": "6994", + "type": "gene", + "text": "Two evolutionarily conserved kinases , the cyclin B ( Clb ) / cyclin - dependent kinase ( Cdk / Cdc28p ) and Cdc7p along with its interacting factor Dbf4p , are required late in G1 to initiate DNA replication .", + "entities": [ + "cyclin B", + "Clb", + "cyclin - dependent kinase", + "Cdk", + "Cdc28p", + "Cdc7p", + "Dbf4p" + ] + }, + { + "id": "6995", + "type": "gene", + "text": "Moreover , radiolabeled EFI , NF - Y , or CBF DNAs give rise to identical gel retardation patterns in extracts from a variety of different cell types .", + "entities": [ + "EFI", + "NF - Y", + "CBF DNAs" + ] + }, + { + "id": "6996", + "type": "gene", + "text": "Laboratory aspects with particular reference to chemotherapy and control .", + "entities": [] + }, + { + "id": "6997", + "type": "gene", + "text": "When expressed per kilogram body weight , mean GIT increased in the dF group from 0 . 14 % to 0 . 16 % above RMR , with a significant decrease from 0 . 15 % to 0 . 13 % in the P group .", + "entities": [] + }, + { + "id": "6998", + "type": "gene", + "text": "However , plasmids carrying the yeast TyrRS gene could not be stably maintained in E . coli .", + "entities": [ + "yeast TyrRS gene" + ] + }, + { + "id": "6999", + "type": "gene", + "text": "Despite total tumor resection , multiple intraperitoneal tumor nodules of varying sizes were found and resected six months and one year later .", + "entities": [] + }, + { + "id": "7000", + "type": "gene", + "text": "SPECT examination of the TMJ using 99m Tc - MDP was performed in 43 patients with arthrographically proven anterior dislocation of the disc and in 30 normals .", + "entities": [] + }, + { + "id": "7001", + "type": "gene", + "text": "Thus , the induction of E2F binding to the E2F - 1 promoter by the E4 - 6 / 7 protein observed in vitro correlates with transactivation of E2F - 1 promoter activity in vivo .", + "entities": [ + "E2F", + "E2F - 1 promoter", + "E4 - 6 / 7 protein", + "E2F - 1 promoter" + ] + }, + { + "id": "7002", + "type": "gene", + "text": "The murine chromosomal locations of the five NMDA receptor channel subunits , the epsilon 1 ( Grin2a ) , epsilon 2 ( Grin2b ) , epsilon 3 ( Grin2c ) , epsilon 4 ( Grin2d ) and zeta 1 ( Grinl ) subunits , were determined using an interspecific backcross mapping panel derived from crosses of [ ( C57BL / 6JxM . spretus ) F1xC57BL / 6J ] mice .", + "entities": [ + "NMDA receptor channel subunits", + "epsilon 1", + "Grin2a", + "epsilon 2", + "Grin2b", + "epsilon 3", + "Grin2c", + "epsilon 4", + "Grin2d", + "zeta 1", + "Grinl" + ] + }, + { + "id": "7003", + "type": "gene", + "text": "Thus , our studies suggest that pV - mediated activation of HIV - 1 LTR activity is controlled by the nuclear translocation of the NF - kappaB transcription factor , which is mediated by IkappaBalpha serine phosphorylation and degradation , but also by a still undefined NF - kappaB - independent pathway .", + "entities": [ + "HIV - 1 LTR", + "NF - kappaB transcription factor", + "IkappaBalpha", + "NF - kappaB" + ] + }, + { + "id": "7004", + "type": "gene", + "text": "In situ hybridization analysis in adult rat tissue reveals good correlation with this pattern and indicates that drm mRNA is most highly expressed in nondividing and terminally differentiated cells , such as neurons , type 1 lung cells , and goblet cells .", + "entities": [ + "drm mRNA" + ] + }, + { + "id": "7005", + "type": "gene", + "text": "Because decreases in the disfluency rates of stutterers were observed during the presentation of all three stimulus words , the data failed to support the operant model .", + "entities": [] + }, + { + "id": "7006", + "type": "gene", + "text": "The films were analyzed using a scanning helium - neon laser densitometer with a small aperture of 5 - 10 microns .", + "entities": [] + }, + { + "id": "7007", + "type": "gene", + "text": "These widely expressed proteins share a C - terminal region that bears significant sequence homology to a group of GDP / GTP exchange proteins for the Rab3 family of small GTP binding proteins .", + "entities": [ + "GDP / GTP exchange proteins", + "Rab3 family", + "small GTP binding proteins" + ] + }, + { + "id": "7008", + "type": "gene", + "text": "Despite the high frequency of natural infection , the seropositive rates of JEV antibody still correlated well with the dose of vaccine received , i . e . , 67 % ( 1122 / 1664 ) , 66 % ( 65 / 97 ) , 33 % ( 4 / 12 ) and 40 % ( 19 / 47 ) for children receiving 3 , 2 , 1 , and 0 dose of JE vaccines , respectively ( P < 0 . 0001 Chi - square for trend test ) .", + "entities": [] + }, + { + "id": "7009", + "type": "gene", + "text": "Urease activity , judged as the amount of ammonia production from urea , could be measured at 25 ng per tube ( S / N = 1 . 5 ) with Jack bean meal urease .", + "entities": [ + "Urease", + "Jack bean meal urease" + ] + }, + { + "id": "7010", + "type": "gene", + "text": "The diagnostic value of blood serum and urinary amylase , lipase , and trypsin in exacerbations of chronic relapsing pancreatitis is discussed .", + "entities": [ + "urinary amylase", + "lipase", + "trypsin" + ] + }, + { + "id": "7011", + "type": "gene", + "text": "Evaluation of left ventricular function using gated planar myocardial imaging with Tc - 99m - MIBI", + "entities": [] + }, + { + "id": "7012", + "type": "gene", + "text": "Thirty percent of patients were tapered off all steroids , and the average steroid dose in the group who received steroids was 8 . 6 mg of prednisone per day .", + "entities": [] + }, + { + "id": "7013", + "type": "gene", + "text": "Codon optimization for high - level expression of human erythropoietin ( EPO ) in mammalian cells .", + "entities": [ + "human erythropoietin", + "EPO" + ] + }, + { + "id": "7014", + "type": "gene", + "text": "The invasive pattern of squamous cell carcinoma in the mandibular gingiva", + "entities": [] + }, + { + "id": "7015", + "type": "gene", + "text": "In ICE gamma , most of the propeptide ( amino acids 20 - 112 ) is deleted , which suggests that it may function as a catalyst for ICE autoprocessing in vivo .", + "entities": [ + "ICE gamma", + "ICE" + ] + }, + { + "id": "7016", + "type": "gene", + "text": "Role of c - myc in simian virus 40 large tumor antigen - induced DNA synthesis in quiescent 3T3 - L1 mouse fibroblasts .", + "entities": [ + "c - myc", + "simian virus 40 large tumor antigen" + ] + }, + { + "id": "7017", + "type": "gene", + "text": "A diagnosis of IgA lambda multiple myeloma with peritoneal involvement was made .", + "entities": [ + "IgA lambda" + ] + }, + { + "id": "7018", + "type": "gene", + "text": "Recent studies have demonstrated that the activated GH receptor can stimulate Stat1 , a cytoplasmic transcription factor that becomes tyrosine phosphorylated and translocates to the nucleus , where it can interact with specific DNA sequences to modulate gene expression .", + "entities": [ + "GH receptor", + "Stat1" + ] + }, + { + "id": "7019", + "type": "gene", + "text": "The sequence of this region shows high G + C content ( 62 % ) , which is particularly emphasized in the 200 bp upstream from the mRNA start ( 80 % G + C ) .", + "entities": [] + }, + { + "id": "7020", + "type": "gene", + "text": "Deglutition is considered to be immature in infants and to mature postnatally .", + "entities": [] + }, + { + "id": "7021", + "type": "gene", + "text": "The IPL1 gene is required for high - fidelity chromosome segregation in the budding yeast Saccharomyces cerevisiae .", + "entities": [ + "IPL1 gene" + ] + }, + { + "id": "7022", + "type": "gene", + "text": "Previous studies have suggested that moderate cooling increases the responsiveness of vascular alpha2 - adrenoceptors .", + "entities": [ + "vascular alpha2 - adrenoceptors" + ] + }, + { + "id": "7023", + "type": "gene", + "text": "Efficacy of first - generation Cavermap to verify location and function of cavernous nerves during radical prostatectomy : a multi - institutional evaluation by experienced surgeons .", + "entities": [] + }, + { + "id": "7024", + "type": "gene", + "text": "The consensus gene order deduced by combining data from both crosses is D2Mit1 - ( Dbh , Notch1 ) - ( Col5a1 , Rxra ) - Spna2 - Ab l - ( Ak1 , Fpgs ) - ( Grp78 , Pbx3 ) - ( Epb7 . 2 , Hc , Gsn ) - Acra .", + "entities": [ + "D2Mit1", + "Dbh", + "Notch1", + "Col5a1", + "Rxra", + "Spna2", + "Ab l", + "Ak1", + "Fpgs", + "Grp78", + "Pbx3", + "Epb7 . 2 , Hc , Gsn", + "Acra" + ] + }, + { + "id": "7025", + "type": "gene", + "text": "Thus , the screen for toxic p53 mutants in yeast can identify novel p53 variants that may be useful in dissecting p53 regulated cellular responses and in developing p53 - based cancer therapies .", + "entities": [ + "p53 mutants", + "p53", + "p53", + "p53" + ] + }, + { + "id": "7026", + "type": "gene", + "text": "Sixteen out of 52 seropositive MS patients ( 30 . 8 % ) showed intrathecal synthesis of C . pneumoniae - specific IgG but only one of 43 seropositive controls ( 2 . 3 % ) .", + "entities": [ + "C . pneumoniae - specific IgG" + ] + }, + { + "id": "7027", + "type": "gene", + "text": "C3 toxin completely inhibited RhoA function , partially inhibited SRE : Luc activity , but had no effect on LPA - stimulated c - Fos expression .", + "entities": [ + "C3 toxin", + "RhoA", + "Luc", + "c - Fos" + ] + }, + { + "id": "7028", + "type": "gene", + "text": "The effectiveness of NRT appears to be largely independent of the intensity of additional support provided to the smoker .", + "entities": [] + }, + { + "id": "7029", + "type": "gene", + "text": "Binding of cell type - specific nuclear proteins to the 5 ' - flanking region of maize C4 phosphoenolpyruvate carboxylase gene confers its differential transcription in mesophyll cells .", + "entities": [ + "maize C4 phosphoenolpyruvate carboxylase gene" + ] + }, + { + "id": "7030", + "type": "gene", + "text": "The MMA , DMA , and TMA methyltransferases are not homologs ; however , like the MMA methyltransferase gene , the genes encoding the DMA and TMA methyltransferases each contain a single in - frame amber codon .", + "entities": [ + "MMA , DMA , and TMA methyltransferases", + "MMA methyltransferase gene", + "DMA and TMA methyltransferases" + ] + }, + { + "id": "7031", + "type": "gene", + "text": "The first exon encodes 66 bp of the 5 ' - untranslated sequence , while exon 2 encodes the coding and 3 ' - untranslated sequences .", + "entities": [] + }, + { + "id": "7032", + "type": "gene", + "text": "The coding sequence for a 260 - amino - acid residue polypeptide was interrupted by a single short intron of 60 base pairs ( bp ) , and about 70 % of the deduced amino acid sequence of the Drosophila PCNA was identical to the rat and human PCNA polypeptides , with conserved unique repeats of leucine in the C - terminal region .", + "entities": [ + "Drosophila PCNA", + "human PCNA polypeptides" + ] + }, + { + "id": "7033", + "type": "gene", + "text": "When multiple copies of the IL - 1 beta NF - kappa B site were linked to an enhancerless simian virus 40 promoter , this element was able to mediate phorbol ester - or lipopolysaccharide - inducible gene expression .", + "entities": [ + "NF - kappa B site", + "simian virus 40 promoter" + ] + }, + { + "id": "7034", + "type": "gene", + "text": "Results of the ECAT Angina Pectoris Study Group .", + "entities": [] + }, + { + "id": "7035", + "type": "gene", + "text": "V .", + "entities": [] + }, + { + "id": "7036", + "type": "gene", + "text": "We report here the cloning of the murine p44 MAP kinase ( extracellular signal - regulated kinase 1 ) gene , the determination of its intron / exon boundaries , and the characterization of its promoter .", + "entities": [ + "MAP kinase", + "extracellular signal - regulated kinase 1" + ] + }, + { + "id": "7037", + "type": "gene", + "text": "The minimal promoter of the RII beta gene was composed of two adjacent functional elements .", + "entities": [ + "RII beta gene" + ] + }, + { + "id": "7038", + "type": "gene", + "text": "Iodine deficiency disorders in Bangladesh .", + "entities": [] + }, + { + "id": "7039", + "type": "gene", + "text": "These results indicate the presence of TATA - unified transcription systems in contemporary eukaryotes and provide insight into the residual need for TBP by all three Pols in other eukaryotes despite a lack of TATA elements in their promoters .", + "entities": [ + "TBP", + "Pols" + ] + }, + { + "id": "7040", + "type": "gene", + "text": "We showed previously that a fusion protein ( GAL4 - p40 ) containing the DNA - binding domain of GAL4 and sequences of chicken l kappa B - alpha ( p40 ) inhibits growth in the yeast Saccharomyces cerevisiae .", + "entities": [ + "GAL4", + "p40", + "GAL4", + "chicken l kappa B - alpha", + "p40" + ] + }, + { + "id": "7041", + "type": "gene", + "text": "Oral candidiasis", + "entities": [] + }, + { + "id": "7042", + "type": "gene", + "text": "Such an intervention may be of considerable use for the treatment of angiogenesis - dependent diseases involving FGF - 2 .", + "entities": [ + "FGF - 2" + ] + }, + { + "id": "7043", + "type": "gene", + "text": "The cleavage site between VPg and RNA dependent RNA polymerase was predicted to be E445 - T446 based on the amino acid sequence analysis of the polyprotein from different sobemoviruses .", + "entities": [ + "VPg", + "RNA dependent RNA polymerase" + ] + }, + { + "id": "7044", + "type": "gene", + "text": "Regional cerebral blood flow ( rCBF ) measurements and psychiatric ratings were performed on seven schizophrenic patients ( mean age = 41 . 4 years ) who had been examined 18 years previously in a study that used similar psychiatric ratings and a comparable rCBF technique .", + "entities": [] + }, + { + "id": "7045", + "type": "gene", + "text": "Analysis of the sequence identified four open reading frames ( ORFs ) which are designated UL1 , UL2 , UL3 , and UL3 . 5 based on their homology with proteins of herpes simplex virus - 1 ( HSV - 1 ) , pseudorabies virus ( PRV ) , equine herpesvirus - 1 , and varicella - zoster virus .", + "entities": [ + "UL1", + "UL2", + "UL3", + "UL3 . 5" + ] + }, + { + "id": "7046", + "type": "gene", + "text": "Consistent with the protein expression data , V beta 8 . 3 gene transcripts were found only in the transgenic lines with the wild - type promoter .", + "entities": [ + "V beta 8 . 3 gene transcripts" + ] + }, + { + "id": "7047", + "type": "gene", + "text": "Cytochrome b in human complex II ( succinate - ubiquinone oxidoreductase ) : cDNA cloning of the components in liver mitochondria and chromosome assignment of the genes for the large ( SDHC ) and small ( SDHD ) subunits to 1q21 and 11q23 .", + "entities": [ + "Cytochrome b", + "human complex II", + "succinate - ubiquinone oxidoreductase", + "SDHC", + "SDHD" + ] + }, + { + "id": "7048", + "type": "gene", + "text": "Apo A - I level was unrelated to age , but increased with ethanol consumption and decreased with adiposity .", + "entities": [ + "Apo A - I" + ] + }, + { + "id": "7049", + "type": "gene", + "text": "A great deal of information is available on the morphology of the claustrum in various animal species , as well as on its neuronal distribution and relationships with the cerebral cortex and other nuclei .", + "entities": [] + }, + { + "id": "7050", + "type": "gene", + "text": "The diabetic state was characterized by mild insulin deficiency , plasma levels being 73 % of controls , and mild hyperglycemia , with nonfasting plasma glucose levels of 1 . 5 times normal .", + "entities": [ + "insulin" + ] + }, + { + "id": "7051", + "type": "gene", + "text": "Lesion diameters of greater than 20 mm and the large sessile - type configurations were factors that were associated with incomplete removal .", + "entities": [] + }, + { + "id": "7052", + "type": "gene", + "text": "Here , the cloning and characterization of S - RNase genes from two species of Rosaceae , apple ( Malus x domestica ) and Japanese pear ( Pyrus serotina ) is described and these sequences are compared with those of other T2 - type RNases .", + "entities": [ + "S - RNase genes", + "T2 - type RNases" + ] + }, + { + "id": "7053", + "type": "gene", + "text": "In a randomised double - blind study , 46 first episode schizophrenics were given pimozide or flupenthixol for up to 5 weeks ; the mean daily dose at the end was 18 . 8 mg pimozide and 20 mg flupenthixol .", + "entities": [] + }, + { + "id": "7054", + "type": "gene", + "text": "The PDE4A - subfamily - specific linker region LR1 , which joins UCR1 and UCR2 , is encoded by two exons , whereas LR2 , which joins UCR2 to the catalytic unit , is encoded by a single exon .", + "entities": [ + "PDE4A - subfamily - specific linker region" + ] + }, + { + "id": "7055", + "type": "gene", + "text": "We have determined that several E1 mutants mapping in both the M and R regions and a single mutant of the upstream regulatory region have a higher transforming activity on mouse C127 cells than the wild - type genome does .", + "entities": [ + "E1 mutants" + ] + }, + { + "id": "7056", + "type": "gene", + "text": "Viral infections have long been suspected to be causative agents in a number of inner ear dysfunctions .", + "entities": [] + }, + { + "id": "7057", + "type": "gene", + "text": "A second even more significant match to this E . coli region was found in the retroviral ribonuclease H ( RNase H ) domain , and corresponds precisely to a region that has been aligned by previous investigators with the E . coli RNase H , suggesting that Pol I helices O and P are homologous to helices A and D of the RNase H crystal structure , respectively .", + "entities": [ + "retroviral ribonuclease H", + "RNase H", + "E . coli RNase H", + "Pol I", + "RNase H" + ] + }, + { + "id": "7058", + "type": "gene", + "text": "Demographic and clinical data were compared with a control group of 339 healthy age - matched women and with a sample of 224 women with wrist fracture .", + "entities": [] + }, + { + "id": "7059", + "type": "gene", + "text": "The pre - and postoperative haemoglobin concentrations in the autologous group were lower by 15 and 10 g / L , respectively , after primary THR and by 10 g / L in both instances after revision THR .", + "entities": [ + "haemoglobin" + ] + }, + { + "id": "7060", + "type": "gene", + "text": "The pharmacokinetic profiles of digoxin and warfarin were not altered by the simultaneous and continued administration of sevelamer .", + "entities": [] + }, + { + "id": "7061", + "type": "gene", + "text": "Oligonucleotides , designed on the basis of conserved flanking amino acid sequence segments within the catalytic domain of eukaryotic protein kinase C ( PKC ) proteins , were used as primers for polymerase chain reactions to amplify a 427 - bp chromosomal DNA fragment from the filamentous fungus Trichoderma reesei .", + "entities": [ + "eukaryotic protein kinase C", + "PKC" + ] + }, + { + "id": "7062", + "type": "gene", + "text": "Below 50 % decrease of PaO2 , NADH was reduced largely .", + "entities": [] + }, + { + "id": "7063", + "type": "gene", + "text": "These and other comparisons suggest that , during evolution , both the RNA - polymerase specificity of telomerase RNA - gene promoters and , more recently , the position of the template sequence in the telomerase RNA changed .", + "entities": [ + "RNA - polymerase", + "telomerase RNA - gene promoters", + "telomerase RNA" + ] + }, + { + "id": "7064", + "type": "gene", + "text": "In this paper , we show that , like BAP2 , the expression of the BAP3 gene in S . cerevisiae is induced by the addition of branched - chain amino acids to the medium .", + "entities": [ + "BAP2", + "BAP3 gene" + ] + }, + { + "id": "7065", + "type": "gene", + "text": "Mutations in the yeast RNA14 and RNA15 genes result in an abnormal mRNA decay rate ; sequence analysis reveals an RNA - binding domain in the RNA15 protein .", + "entities": [ + "yeast RNA14", + "RNA15 genes", + "RNA15 protein" + ] + }, + { + "id": "7066", + "type": "gene", + "text": "One gene appears ubiquitously expressed while the other is prominently expressed in muscle .", + "entities": [] + }, + { + "id": "7067", + "type": "gene", + "text": "Batch cultures of S . mutans serotype a demonstrated no growth on MSB agar .", + "entities": [] + }, + { + "id": "7068", + "type": "gene", + "text": "VaI and VaII co - immunoprecipitated with ErbB2 , but not with ErbB1 , ErbB3 , or ErbB4 .", + "entities": [ + "ErbB2", + "ErbB1", + "ErbB3", + "ErbB4" + ] + }, + { + "id": "7069", + "type": "gene", + "text": "Restriction mapping analysis localized this cDNA to the HHV - 6A ( U1102 ) genomic BamHI G fragment , at the right end of the unique long segment of the genome and to the SalI L and SalI O fragments within the left and right terminal direct repeat regions , respectively .", + "entities": [ + "HHV - 6A ( U1102 ) genomic BamHI G fragment", + "SalI L", + "SalI O fragments" + ] + }, + { + "id": "7070", + "type": "gene", + "text": "Assembly of a complex between FAK and Src kinases may serve to regulate the subcellular localization and the enzymatic activity of members of the Src family of kinases .", + "entities": [ + "FAK", + "Src kinases", + "Src family" + ] + }, + { + "id": "7071", + "type": "gene", + "text": "Adaptation of taurocholate transport maximum to increased secretory load in the rat .", + "entities": [] + }, + { + "id": "7072", + "type": "gene", + "text": "The level of carboxyl - terminal parathyroid hormone in the patients with thyroid carcinoma was higher than that in the patients without thyroid carcinoma ( P less than 0 . 05 ) .", + "entities": [ + "carboxyl - terminal parathyroid hormone" + ] + }, + { + "id": "7073", + "type": "gene", + "text": "The Euglena ribosomal protein gene cluster resembles the S - 10 ribosomal protein operon of Escherichia coli in gene organization and follows the exact linear order of the analogous genes in the tobacco and liverwort chloroplast genomes .", + "entities": [ + "Euglena ribosomal protein gene cluster", + "S - 10 ribosomal protein operon of Escherichia coli" + ] + }, + { + "id": "7074", + "type": "gene", + "text": "HTLV - 1 gene expression by defective proviruses in an infected T - cell line .", + "entities": [] + }, + { + "id": "7075", + "type": "gene", + "text": "HCV infection acquired during or after BMT caused only mild acute hepatitis C , which progressed to chronic hepatitis C in one patient surviving 10 years after BMT .", + "entities": [] + }, + { + "id": "7076", + "type": "gene", + "text": "Hepatocellular injury during preservation of human livers with UW and HTK solution .", + "entities": [] + }, + { + "id": "7077", + "type": "gene", + "text": "Sequence analysis reveals that the newly discovered oasA2 gene represents a pseudogene that is still transcribed , but is not functionally translated .", + "entities": [ + "oasA2 gene" + ] + }, + { + "id": "7078", + "type": "gene", + "text": "Moreover , in transient transfection assays , PU . 1 alone activated reporter constructs containing the JB cis - element , and the activation was shown to be dependent on a glutamine - rich sequence in the amino - terminal portion of PU . 1 .", + "entities": [ + "PU . 1", + "PU . 1" + ] + }, + { + "id": "7079", + "type": "gene", + "text": "Brucellosis - - 1990", + "entities": [] + }, + { + "id": "7080", + "type": "gene", + "text": "H - 7 , which specifically , although weakly , inhibited PKC activation , had no effect on tyrosine phosphorylation and PtdIns ( 3 , 4 ) P2 production .", + "entities": [ + "PKC" + ] + }, + { + "id": "7081", + "type": "gene", + "text": "It is also homologous to other sugar carriers from human , mouse and Escherichia coli .", + "entities": [] + }, + { + "id": "7082", + "type": "gene", + "text": "Adjustment for age , total cholesterol , HDL cholesterol , triglycerides , current smoking , and systolic pressure slightly reduced the association between fibrinogen and atherosclerosis .", + "entities": [ + "HDL cholesterol", + "fibrinogen" + ] + }, + { + "id": "7083", + "type": "gene", + "text": "Although we predicted that overexpression of the COOH - terminal domains , which were thought to be involved in the regulation of SREBP processing , would result in disruption of the SREBP - dependent transcriptional regulation of several genes , the mRNA levels for 3 - hydroxy - 3 - methylglutaryl coenzyme A ( HMG CoA ) synthase in these two cell lines were regulated in a sterol - dependent manner .", + "entities": [ + "SREBP", + "SREBP", + "3 - hydroxy - 3 - methylglutaryl coenzyme A ( HMG CoA ) synthase" + ] + }, + { + "id": "7084", + "type": "gene", + "text": "A statistically significant improvement due to the administration of Bromergon was observed in symptoms associated with overreactiveness to normal prolactin levels , i . e . abdominal tension , edema , weight gain and breast tenderness .", + "entities": [ + "prolactin" + ] + }, + { + "id": "7085", + "type": "gene", + "text": "Liver dysfunction in the presence of different adverse reactions presented with a higher activity in the blood serum of indicator liver enzymes and its impaired protein - forming function .", + "entities": [] + }, + { + "id": "7086", + "type": "gene", + "text": "However , unlike the SIN3 gene of Saccharomyces cerevisiae , pst1 ( + ) is essential for cell viability .", + "entities": [ + "SIN3 gene", + "pst1 ( + )" + ] + }, + { + "id": "7087", + "type": "gene", + "text": "Importantly , concomitant expression of constitutive activated Raf and V12N38 Ras results in almost complete loss of TTF - 1 activity .", + "entities": [ + "Raf", + "V12N38 Ras", + "TTF - 1" + ] + }, + { + "id": "7088", + "type": "gene", + "text": "The peroxisome biogenesis disorders ( PBDs ) are a set of lethal genetic diseases characterized by peroxisomal metabolic deficiencies , multisystem abnormalities , mental retardation , and premature death .", + "entities": [] + }, + { + "id": "7089", + "type": "gene", + "text": "The sub - acute inhalation toxicity of furfural was studied in Syrian golden hamsters .", + "entities": [] + }, + { + "id": "7090", + "type": "gene", + "text": "A .", + "entities": [] + }, + { + "id": "7091", + "type": "gene", + "text": "Here we report that in cultured cells from Drosophila melanogaster human Sp1 efficiently activates transcription from synthetic promoters containing TATA boxes , but not from promoters that contain an initiator instead of a TATA box .", + "entities": [ + "human Sp1" + ] + }, + { + "id": "7092", + "type": "gene", + "text": "D3S1261 is physically located at or near the MITF locus , while D3S2465 and D3S1766 are flanking the locus at about 17 . 5 cM genetic distance each side .", + "entities": [ + "D3S1261", + "MITF locus", + "D3S2465", + "D3S1766" + ] + }, + { + "id": "7093", + "type": "gene", + "text": "Altogether , these data suggest that Ypt51p , Ypt52p , and Ypt53p are required for transport in the endocytic pathway and for correct sorting of vacuolar hydrolases suggesting a possible intersection of the endocytic with the vacuolar sorting pathway .", + "entities": [ + "Ypt51p", + "Ypt52p", + "Ypt53p", + "vacuolar hydrolases" + ] + }, + { + "id": "7094", + "type": "gene", + "text": "These results indicate that both PKC alpha ( calcium dependent ) and PKC delta ( calcium independent ) may mediate the transcription of TPA - inducible genes through both AP - 1 and non - AP - 1 sequences .", + "entities": [ + "PKC alpha", + "PKC delta", + "AP - 1", + "AP - 1" + ] + }, + { + "id": "7095", + "type": "gene", + "text": "Endometrial biopsies and plasma oestradiol ( E2 ) and progesterone ( P4 ) levels in 23 patients were evaluated during 26 replacement therapy cycles for premature ovarian failure .", + "entities": [] + }, + { + "id": "7096", + "type": "gene", + "text": "Mapping of the DNA binding domain of the copper - responsive transcription factor Mac1 from Saccharomyces cerevisiae .", + "entities": [ + "Mac1 from Saccharomyces cerevisiae" + ] + }, + { + "id": "7097", + "type": "gene", + "text": "Tiaprofenic acid overdose .", + "entities": [] + }, + { + "id": "7098", + "type": "gene", + "text": "Mean weighted skin temperature ( Tsk ) was lower ( P less than 0 . 01 ) following acclimation than before , and acclimation resulted in a larger ( P less than 0 . 02 ) Tre - to - Tsk gradient .", + "entities": [] + }, + { + "id": "7099", + "type": "gene", + "text": "In addition , we identified a novel type of inhibitory domain in the N - terminal 60 amino acids of IRF - 1 which strongly inhibits its transcriptional activity .", + "entities": [ + "IRF - 1" + ] + }, + { + "id": "7100", + "type": "gene", + "text": "Several free 2nd - generation schizonts , which varied in diameter from 11 to 21 . 6 micrometer , were found on the epithelial surface of the cecum .", + "entities": [] + }, + { + "id": "7101", + "type": "gene", + "text": "A new echocardiographic technique is described with a conventional M mode , digitalised 2D and tissular Doppler which has a comparable ability to identify the anomalous pathways of electric conduction using a non - invasive method .", + "entities": [] + }, + { + "id": "7102", + "type": "gene", + "text": "In the Center for Human Genetics in Leuven , predictive DNA - testing for Huntington ' s disease is available as a clinical service since November 1987 , initially by DNA - linkage and since mid 1993 by direct mutation analysis .", + "entities": [] + }, + { + "id": "7103", + "type": "gene", + "text": "Contrary to the observation made with other S . pombe genes transcribed in the budding yeast , the heterologous actin gene transcript is initiated 39 nucleotides upstream of the initiation start site used in the homologous yeast .", + "entities": [ + "actin gene transcript" + ] + }, + { + "id": "7104", + "type": "gene", + "text": "Calcifications in the thoracic aorta at the level of the 11th and the 12th thoracic vertebrae in 592 men and 333 women were studied using computed tomography .", + "entities": [] + }, + { + "id": "7105", + "type": "gene", + "text": "Inactivation of Ulp2 also suppresses several ulp1 ( ts ) defects , and the double mutant accumulates far fewer Smt3 - protein conjugates than either single mutant .", + "entities": [ + "Ulp2", + "ulp1 ( ts )", + "Smt3 - protein" + ] + }, + { + "id": "7106", + "type": "gene", + "text": "In order to study the structural and functional organization of the eukaryotic nucleolus , we have started to isolate and characterize nucleolar components of the yeast Saccharomyces cerevisiae .", + "entities": [] + }, + { + "id": "7107", + "type": "gene", + "text": "Two variant PRP - precursor alleles occur which slightly differ in the number of repeats in domain C .", + "entities": [ + "PRP - precursor alleles" + ] + }, + { + "id": "7108", + "type": "gene", + "text": "Elledge , P .", + "entities": [] + }, + { + "id": "7109", + "type": "gene", + "text": "Against 200 strains of methicillin - resistant Staphylococcus aureus ( MRSA ) isolated from 1990 to 1991 , minimum inhibitory concentrations ( MICs ) of a total of 15 antibacterial agents including arbekacin ( ABK ) were determined .", + "entities": [] + }, + { + "id": "7110", + "type": "gene", + "text": "Dr .", + "entities": [] + }, + { + "id": "7111", + "type": "gene", + "text": "Epithelial damage was not observed in any controls but was in all tissues exposed to SO2 .", + "entities": [] + }, + { + "id": "7112", + "type": "gene", + "text": "The mobility of the upper and lower premolars under load was investigated in relation to the interproximal contact and occlusal facets .", + "entities": [] + }, + { + "id": "7113", + "type": "gene", + "text": "Binding specificity and modulation of the ApoA - I promoter activity by homo - and heterodimers of nuclear receptors .", + "entities": [ + "ApoA - I promoter" + ] + }, + { + "id": "7114", + "type": "gene", + "text": "Paleoceanographic data from the Laurentian Fan , used as a proxy for sea surface temperature , reveal that surface slope waters north of the Gulf Stream experienced warming during the Little Ice Age of the 16th to 19th centuries and support the notion of an NAO - driven coupled system .", + "entities": [] + }, + { + "id": "7115", + "type": "gene", + "text": "The Aa - Pri2 gene , specifically expressed during basidiocarp differentiation of the mushroom Agrocybe aegerita , was cloned .", + "entities": [ + "Aa - Pri2 gene" + ] + }, + { + "id": "7116", + "type": "gene", + "text": "A long follow - up study revealed that convalescent stage children still have the potency to have an immediate type hypersensitivity reaction on exposure to mite antigen , with a high titer of mite specific IgE in their sera , but they are free from asthmatic attacks because of the reduction in the amount of mite antigen in the body , as shown by the reduction in the amount of mite specific IgG .", + "entities": [ + "mite specific IgE", + "mite specific IgG" + ] + }, + { + "id": "7117", + "type": "gene", + "text": "Previous studies characterized a cytokine - inducible , functional nuclear factor ( NF ) - kappaB consensus element in the immediate 5 ' regulatory region of the MGSA / GRO - alpha gene at - 78 bp .", + "entities": [ + "nuclear factor ( NF ) - kappaB consensus element", + "MGSA", + "GRO - alpha" + ] + }, + { + "id": "7118", + "type": "gene", + "text": "Rapamycin ( FRAP / mTOR inhibitor ) blocked 4E - BP1 phosphorylation causing a predominance of the alpha ( hypophosphorylated ) band .", + "entities": [ + "FRAP", + "mTOR", + "4E - BP1" + ] + }, + { + "id": "7119", + "type": "gene", + "text": "The metabolic events occurring at or near that structure and involving cyclin D3 cause the translocation of ICP0 to the cytoplasm .", + "entities": [ + "cyclin D3", + "ICP0" + ] + }, + { + "id": "7120", + "type": "gene", + "text": "The Menopause - Rating - Scale ( MRS I ) was used in clinical practice since 1992 .", + "entities": [] + }, + { + "id": "7121", + "type": "gene", + "text": "Transcription of the metH gene in Salmonella typhimurium and Escherichia coli is positively regulated by the metR gene product , a DNA binding protein .", + "entities": [ + "metH gene in Salmonella typhimurium and Escherichia coli", + "metR gene product" + ] + }, + { + "id": "7122", + "type": "gene", + "text": "A distinct staining pattern for the N - utrophin was not detectable , although it was expected to localise at the actin stress fibers .", + "entities": [ + "N - utrophin", + "actin" + ] + }, + { + "id": "7123", + "type": "gene", + "text": "Moreover , the major site of transcriptional initiation , which was localized by primer extension 250 bp upstream of the 5 ' end of the Ets - 1 cDNA clone , was shown to be identical in normal cells and tumors carrying a provirus in the Tpl - 1 locus .", + "entities": [ + "Ets - 1 cDNA clone", + "Tpl - 1 locus" + ] + }, + { + "id": "7124", + "type": "gene", + "text": "Neurospora crassa CYT - 18 , can rescue the exonic trap and intron mutants which cause a structural defect .", + "entities": [ + "CYT - 18" + ] + }, + { + "id": "7125", + "type": "gene", + "text": "Animals may be immunized by oral vaccination , but natural mechanisms that also can terminate outbreaks are discussed .", + "entities": [] + }, + { + "id": "7126", + "type": "gene", + "text": "Likewise , at 150 degrees C with 2 % APS the surface density of NH2 groups reached a maximum at 24 hr and remained relatively constant up to 96 hr .", + "entities": [] + }, + { + "id": "7127", + "type": "gene", + "text": "Long - range comparison of human and mouse SCL loci : localized regions of sensitivity to restriction endonucleases correspond precisely with peaks of conserved noncoding sequences .", + "entities": [ + "human and mouse SCL loci" + ] + }, + { + "id": "7128", + "type": "gene", + "text": "Because of its great reliability , conventional arteriography occupies a place of choice among the medical imaging techniques .", + "entities": [] + }, + { + "id": "7129", + "type": "gene", + "text": "To investigate the regulation of Spec gene activity , the region around the Spec1 transcriptional initiation site was analyzed for sites of protein - DNA interaction .", + "entities": [ + "Spec gene", + "Spec1 transcriptional initiation site" + ] + }, + { + "id": "7130", + "type": "gene", + "text": "Phosphoamino acid analysis of radiolabeled ASGPR subunits identified Ser ( P ) as the predominant ( approximately 95 % ) and Thr ( P ) as a minor ( approximately 5 % ) phosphoamino acid in each polypeptide and confirmed the presence of Tyr ( P ) ( approximately 1 % ) in RHL1 .", + "entities": [ + "ASGPR subunits", + "RHL1" + ] + }, + { + "id": "7131", + "type": "gene", + "text": "Neonatal lupus erythematosus is most often associated with autoantibodies against Ro and La antigens .", + "entities": [ + "Ro", + "La" + ] + }, + { + "id": "7132", + "type": "gene", + "text": "Two sterol regulatory element - like sequences mediate up - regulation of caveolin gene transcription in response to low density lipoprotein free cholesterol .", + "entities": [ + "caveolin gene", + "low density lipoprotein" + ] + }, + { + "id": "7133", + "type": "gene", + "text": "In the face of the outbreak , there was a delay before vaccination was able to stop deaths .", + "entities": [] + }, + { + "id": "7134", + "type": "gene", + "text": "Myocardial SPET imaging with 99Tcm - tetrofosmin in clinical practice : comparison of a 1 day and a 2 day imaging protocol .", + "entities": [] + }, + { + "id": "7135", + "type": "gene", + "text": "The amino acid changes D206A and D208A abolish singly or in combination the exonuclease activity in vivo .", + "entities": [] + }, + { + "id": "7136", + "type": "gene", + "text": "Subcutaneous administration of the somatostatin analogue , octreotide , 100 micrograms thrice daily , resulted in a sustained improvement in diarrhoea and disappearance of faecal incontinence without reducing calcitonin levels .", + "entities": [ + "somatostatin", + "calcitonin" + ] + }, + { + "id": "7137", + "type": "gene", + "text": "Human cytomegalovirus immediate - early protein IE2 tethers a transcriptional repression domain to p53 .", + "entities": [ + "Human cytomegalovirus immediate - early protein IE2", + "p53" + ] + }, + { + "id": "7138", + "type": "gene", + "text": "Epileptiform activity recorded from superficial laminae bordering layer 4 , and into which layer 4 ' s primary projections terminate , is suppressed preferentially by phenytoin .", + "entities": [] + }, + { + "id": "7139", + "type": "gene", + "text": "Antibodies raised against GST mSH2 - B identified a cellular protein of 92 kDa that was not found to be phosphorylated on Tyr .", + "entities": [ + "GST mSH2 - B" + ] + }, + { + "id": "7140", + "type": "gene", + "text": "Transactivation domain is located downstream of the 128 - amino - acid runt homology region , referred to as the Runt domain .", + "entities": [ + "128 - amino - acid runt homology region", + "Runt domain" + ] + }, + { + "id": "7141", + "type": "gene", + "text": "In cerebrospinal fluid , an ADA catalytic concentration above 0 . 15 mu kat / L strongly suggests tuberculous meningitis in patients older than 7 years ( sensitivity 1 . 00 , specificity 0 . 99 and efficiency 0 . 99 ) .", + "entities": [ + "ADA" + ] + }, + { + "id": "7142", + "type": "gene", + "text": "Studies of lipoproteins should , however , be made in children from families known to have FH or early coronary heart disease .", + "entities": [] + }, + { + "id": "7143", + "type": "gene", + "text": "Their circadian responses to both photic and non - photic cues were then tested .", + "entities": [] + }, + { + "id": "7144", + "type": "gene", + "text": "Beta 1 integrin - and proteoglycan - mediated stimulation of T lymphoma cell adhesion and mitogen - activated protein kinase signaling by thrombospondin - 1 and thrombospondin - 1 peptides .", + "entities": [ + "Beta 1 integrin", + "mitogen - activated protein kinase", + "thrombospondin - 1", + "thrombospondin - 1 peptides" + ] + }, + { + "id": "7145", + "type": "gene", + "text": "Most of the prepeptide portion of the precursor polypeptide is encoded by the next three exons , and the mature form of IL - 1 alpha is encoded by the remaining three exons .", + "entities": [ + "IL - 1 alpha" + ] + }, + { + "id": "7146", + "type": "gene", + "text": "Many studies have pointed out the possibility of \" masked \" organic factors in erectile impotence , detectable only by means of laboratory investigations : mild hypogonadism , hyperprolactinemia , occlusions selectively located at the site of the sexual arteries , venous incompetence , subclinical neuropathies .", + "entities": [] + }, + { + "id": "7147", + "type": "gene", + "text": "Consumption of 4 % sucrose was not affected by excitotoxic lesions of the PPTg , but PPTg lesioned rats consumed significantly more 12 % and 20 % sucrose than sham controls .", + "entities": [] + }, + { + "id": "7148", + "type": "gene", + "text": "Eleven biopsy specimens ( five papules and six dusky or crusted lesions ) from four patients with pityriasis lichenoides et varioliformis acuta ( PLEVA ) were studied by direct immunofluorescence and immunoperoxidase technics .", + "entities": [ + "immunoperoxidase" + ] + }, + { + "id": "7149", + "type": "gene", + "text": "Both the intact A1 protein and its proteolytic fragment , the UP1 protein , can be cleaved by Staphylococcus aureus V - 8 protease to produce two polypeptides of 92 amino acids .", + "entities": [ + "intact A1 protein", + "UP1 protein", + "Staphylococcus aureus V - 8 protease" + ] + }, + { + "id": "7150", + "type": "gene", + "text": "The second and third responded similarly to either a combined cyclophosphamide + antilymphocyte globulin ( ALG ) treatment or to ALG administration preceded by a small dosage of cyclophosphamide , which had proved ineffective when administered alone .", + "entities": [ + "antilymphocyte globulin", + "ALG", + "ALG" + ] + }, + { + "id": "7151", + "type": "gene", + "text": "Blocked shift / supershift analysis indicates that Fos family member proteins especially Fra - 1 and Fra - 2 are related to progression and no changes found in the Jun family member proteins although they are present in the AP - 1 / DNA binding complex .", + "entities": [ + "Fos family", + "Fra - 1", + "Fra - 2", + "Jun family", + "AP - 1 / DNA binding complex" + ] + }, + { + "id": "7152", + "type": "gene", + "text": "Having an LRR domain and an SH3 - binding domain , Acan125 and the C . elegans homologue define a novel family of bifunctional binding proteins .", + "entities": [ + "LRR domain", + "SH3 - binding domain", + "Acan125" + ] + }, + { + "id": "7153", + "type": "gene", + "text": "Structure of the gene encoding the human cyclin - dependent kinase inhibitor p18 and mutational analysis in breast cancer .", + "entities": [ + "cyclin - dependent kinase", + "p18" + ] + }, + { + "id": "7154", + "type": "gene", + "text": "ICA in the reference solution was characterised by LC and time - of - flight ( TOF ) MS and quantified by LC chemiluminescent nitrogen detection ( LC - CLND ) .", + "entities": [] + }, + { + "id": "7155", + "type": "gene", + "text": "In most cases , DR4 - homozygous , DRB1 - heterozygous individuals could be genotyped with the panel of probes .", + "entities": [ + "DR4", + "DRB1" + ] + }, + { + "id": "7156", + "type": "gene", + "text": "A total of 117 EVS treatments were performed on 34 patients .", + "entities": [] + }, + { + "id": "7157", + "type": "gene", + "text": "Ang II significantly induced Ang2 mRNA accumulations without affecting Ang1 or Tie2 expression , which was inhibited by protein kinase C inhibitors and by intracellular Ca ( 2 + ) chelating agents .", + "entities": [ + "Ang II", + "Ang2 mRNA", + "Ang1", + "Tie2", + "protein kinase C" + ] + }, + { + "id": "7158", + "type": "gene", + "text": "Northern blotting showed that MDMX , like MDM2 , is expressed in all tissues tested , and that several mRNAs for MDMX can be detected .", + "entities": [ + "MDMX", + "MDM2", + "MDMX" + ] + }, + { + "id": "7159", + "type": "gene", + "text": "The nucleotide sequence alignment between mouse and human CA IV shows 69 % identity in the coding region and all of the exon - intron boundaries are conserved , as are the sizes of the introns .", + "entities": [ + "human CA IV" + ] + }, + { + "id": "7160", + "type": "gene", + "text": "Out of these families 74 , 3 % planned next pregnancy ( table IX ) , 57 , 6 % wanted to have prenatal diagnosis ( table VI ) .", + "entities": [] + }, + { + "id": "7161", + "type": "gene", + "text": "A major pool of Dsg - plakoglobin complexes sedimented at 8S and exhibited a 1 : 1 stoichiometry .", + "entities": [ + "Dsg", + "plakoglobin" + ] + }, + { + "id": "7162", + "type": "gene", + "text": "Videonystagmoscopy has been used to subjectively observe the responses of the vestibular system in a population of patients with vestibular deficits .", + "entities": [] + }, + { + "id": "7163", + "type": "gene", + "text": "Pretreatment of cells with the mitogen - activated protein - extracellular signal - regulated kinase kinase ( MEK ) inhibitor U0126 inhibited S6K2 activation to a greater extent than S6K1 .", + "entities": [ + "mitogen - activated protein - extracellular signal - regulated kinase kinase", + "MEK", + "S6K2", + "S6K1" + ] + }, + { + "id": "7164", + "type": "gene", + "text": "Can survival be prolonged for patients with hormone - resistant prostate cancer ?", + "entities": [] + }, + { + "id": "7165", + "type": "gene", + "text": "Here we have tested the hypothesis that the short transcripts , or proteins translated from the short transcripts , are also required for respiration .", + "entities": [] + }, + { + "id": "7166", + "type": "gene", + "text": "Radionuclide angiography and static whole body imaging performed with technetium - 99m - labeled particulates can clearly demonstrate differential shunting in patients with patent ductus arteriosus ( PDA ) with Eisenmenger physiology .", + "entities": [] + }, + { + "id": "7167", + "type": "gene", + "text": "In contrast , peak filling rate ( PFR ) , normalized to end diastolic volume ( EDV ) , or stroke volume ( SV ) , or expressed as the ratio of PFR - to - PER was reduced ( p < 0 . 01 ) , time to PFR ( TPFR ) was prolonged ( p < 0 . 01 ) , and echocardiographic left ventricular mass index was higher ( p < 0 . 001 ) in patients with acromegaly compared to normals .", + "entities": [] + }, + { + "id": "7168", + "type": "gene", + "text": "With a GC content of 45 % the one segment would correspond to \" isochore H1 \" and the other segment ( 39 % GC in human , 40 % GC in mouse ) to \" isochore L1 / L2 \" .", + "entities": [ + "\" isochore H1 \"", + "L1", + "L2" + ] + }, + { + "id": "7169", + "type": "gene", + "text": "Some users will willingly comply with management measures , other users will comply in response to education , but there will be another group who will only respond to enforcement activities .", + "entities": [] + }, + { + "id": "7170", + "type": "gene", + "text": "Second , the transcription factor Gal - ER was rendered more potent and less susceptible to cell type - specific variation by fusing the strong activating domain of the herpesvirus protein VP16 onto its C terminus .", + "entities": [ + "transcription factor Gal - ER", + "herpesvirus protein VP16" + ] + }, + { + "id": "7171", + "type": "gene", + "text": "All tumors proved histologically to be neuroendocrine in origin .", + "entities": [] + }, + { + "id": "7172", + "type": "gene", + "text": "Epithelial cytotoxicity of combined antibiotics was additive , with no evidence of competition or synergism .", + "entities": [] + }, + { + "id": "7173", + "type": "gene", + "text": "In addition , the transcription of c - IAP2 promoter was strongly up - regulated when CD40 or Epstein - Barr virus latent membrane protein 1 was overexpressed .", + "entities": [ + "c - IAP2 promoter", + "CD40", + "Epstein - Barr virus latent membrane protein 1" + ] + }, + { + "id": "7174", + "type": "gene", + "text": "Sequence requirements for premature transcription arrest within the first intron of the mouse c - fos gene .", + "entities": [ + "mouse c - fos gene" + ] + }, + { + "id": "7175", + "type": "gene", + "text": "The retention of 75SeHCAT was low .", + "entities": [] + }, + { + "id": "7176", + "type": "gene", + "text": "To evaluate the effects of HRT on those factors in end - stage renal disease ( ESRD ) patients , we evaluated the changes of lipid profile , coagulation and fibrinolysis markers , and plasma homocysteine levels after treatment .", + "entities": [] + }, + { + "id": "7177", + "type": "gene", + "text": "Vibrio cholerae O139 in Calcutta .", + "entities": [] + }, + { + "id": "7178", + "type": "gene", + "text": "RESULT ( S ) : In patients with elevated FSH levels on cycle day 3 , a low oocyte yield was achieved ( 7 versus 11 ) and a high number of ampules of hMG was necessary ( 56 versus 33 ) .", + "entities": [ + "FSH", + "hMG" + ] + }, + { + "id": "7179", + "type": "gene", + "text": "A panel of pharmacologic inhibitors was used to investigate the signal transduction pathways involved in TRAIL gene induction following T lymphocyte activation .", + "entities": [ + "TRAIL gene" + ] + }, + { + "id": "7180", + "type": "gene", + "text": "Retention behavior of steroids in gas chromatography with a series of combination columns .", + "entities": [] + }, + { + "id": "7181", + "type": "gene", + "text": "We studied the effect of skinfold thickness on the correlation between serum total bilirubin level and transcutaneous bilirubin ( TcB ) readings .", + "entities": [] + }, + { + "id": "7182", + "type": "gene", + "text": "The rates of total energy use ( mean + / - SD = 39 . 3 + / - 1 . 2 vs 35 . 7 + / - 1 . 3 kJ X min - 1 ; P less than 0 . 05 ) were significantly higher at - 10 degrees C than at 22 degrees C .", + "entities": [] + }, + { + "id": "7183", + "type": "gene", + "text": "The availability of cryoprecipitate and DDAVP offers an alternative and effective treatment for the temporary reversal of uremic bleeding in patients who require urgent invasive procedures .", + "entities": [] + }, + { + "id": "7184", + "type": "gene", + "text": "CONCLUSIONS : Under current immunization practices , the authors estimate that nearly 13 , 000 Asian and Pacific Islander children living in the United States today will become infected with HBV in the future , resulting in more than 600 liver carcinoma deaths .", + "entities": [] + }, + { + "id": "7185", + "type": "gene", + "text": "Hodgkin ' s disease .", + "entities": [] + }, + { + "id": "7186", + "type": "gene", + "text": "There was no evidence of linkage disequilibrium between the polymorphic site in the B cell specific promoter and those in the 3 ' UTR .", + "entities": [] + }, + { + "id": "7187", + "type": "gene", + "text": "Measurements were compared with two computerised treatment planning systems - - Theraplan VO5B and ADAC Pinnacle3 V4 . 0b .", + "entities": [] + }, + { + "id": "7188", + "type": "gene", + "text": "To gain further insight into the pathogenesis of the adult respiratory distress syndrome ( ARDS ) , the authors studied possible relationships among the activation status of circulating polymorphonuclear neutrophils ( PMN ) , cytokine levels , and the severity of lung injury in 31 patients : 15 with ARDS , 9 with severe pneumonia uncomplicated by ARDS , and 7 mechanically ventilated patients with neither ARDS nor pneumonia .", + "entities": [] + }, + { + "id": "7189", + "type": "gene", + "text": "For 85Sr , larger - than - expected distribution coefficients were obtained in the desorption experiments , an indication of the irreversible formation of metal - oxyhydroxides during a slow reaction .", + "entities": [] + }, + { + "id": "7190", + "type": "gene", + "text": "There were 5 treatments : control ( C ) ; a wooden surround in one rear corner of the cage ( S ) ; a fiberglass rollaway hollow in one rear corner of the cage ( H ) ; a hollow and a surround ( H / S ) ; a nest box attached to the back of the cage , containing a hollow ( N ) .", + "entities": [] + }, + { + "id": "7191", + "type": "gene", + "text": "Pharmacologic doses of vitamin B6 administered to lactating women have been reported to suppress plasma prolactin .", + "entities": [ + "plasma prolactin" + ] + }, + { + "id": "7192", + "type": "gene", + "text": "METHODS : In the current study the authors reported on PPB cases from a national retrospective search performed in 18 Italian Associations for Pediatric Hematology and Oncology centers .", + "entities": [] + }, + { + "id": "7193", + "type": "gene", + "text": "Univariate statistical analysis based on Kaplan - Meier - estimates and Log - Rank - Test showed the following prognostically beneficial factors : Limited disease stage ( p = 0 . 009 ) , NSE serum level less than 25 micrograms / l ( p = 0 . 016 ) , serum alkaline phosphatase less than 200 U / l ( p = 0 . 035 ) , normal serum albumin ( p = 0 . 003 ) and activity index of minimum of 70 ( p < 0 . 001 ) .", + "entities": [ + "NSE", + "alkaline phosphatase", + "albumin" + ] + }, + { + "id": "7194", + "type": "gene", + "text": "A rather similar pattern of results was obtained with respect to LMP2B mRNA expression , such transcripts being detectable only in a subset of tumors , and then at apparently low levels .", + "entities": [ + "LMP2B mRNA" + ] + }, + { + "id": "7195", + "type": "gene", + "text": "The ORF3 mutant produced reduced levels of tabtoxin , indicating that ORF3 may have a role in T beta L biosynthesis .", + "entities": [ + "tabtoxin", + "T beta L" + ] + }, + { + "id": "7196", + "type": "gene", + "text": "While daily food intake was almost constant regardless of the dietary protein level , water intake and urine volume increased with increasing the dietary protein .", + "entities": [] + }, + { + "id": "7197", + "type": "gene", + "text": "On the other hand , lack of conservation of the membrane attachment sequence arginine - glycine - aspartic acid argues against its functional importance in CgA .", + "entities": [ + "CgA" + ] + }, + { + "id": "7198", + "type": "gene", + "text": "Radioligand binding was indistinguishable for both transiently expressed constructs .", + "entities": [] + }, + { + "id": "7199", + "type": "gene", + "text": "Exons III to VIII , which cover the coding region and the 3 ' untranslated region , are almost identical in all types of PST or AST cDNAs .", + "entities": [ + "PST", + "AST cDNAs" + ] + }, + { + "id": "7200", + "type": "gene", + "text": "Simple method for determination of the cephalosporin DQ - 2556 in biological fluids by high - performance liquid chromatography .", + "entities": [] + }, + { + "id": "7201", + "type": "gene", + "text": "Viral RNA , molecularly cloned proviral DNA , and virus - specific protein of avian retrovirus MH2 were analyzed .", + "entities": [] + }, + { + "id": "7202", + "type": "gene", + "text": "Diagnosis of FHCS has been weighed upon laparoscopic findings .", + "entities": [] + }, + { + "id": "7203", + "type": "gene", + "text": "We critically assess current systematic uncertainties and determine the primordial Li abundance within new , much tighter limits : & amp ; parl0 ; Li & amp ; solm0 ; H & amp ; parr0 ; p = 1 . 23 + 0 . 68 - 0 . 32x10 - 10 .", + "entities": [] + }, + { + "id": "7204", + "type": "gene", + "text": "Deletion mapping studies revealed that the upstream DNA sequences up to - 86 were sufficient for the optimal basal level transcription in HeLa cells and also for the EIA - induced transcription .", + "entities": [ + "EIA" + ] + }, + { + "id": "7205", + "type": "gene", + "text": "Influence of different methods of chemical disinfection on the physical properties of type IV and V gypsum dies ] Several instruments and materials frequently used in prosthodontics - - such as stone casts , dental impressions , interocclusal records - - are classified , by the dental literature , as vehicles of transmission of infectious diseases to those who handle them .", + "entities": [] + }, + { + "id": "7206", + "type": "gene", + "text": "The purpose of this study was to analyze the temporal characteristics and the spatial mapping of the independent components identified by ICA when the subject performs a finger - tapping task .", + "entities": [] + }, + { + "id": "7207", + "type": "gene", + "text": "A transcript of about 2 kb is expected for each PPO .", + "entities": [ + "PPO" + ] + }, + { + "id": "7208", + "type": "gene", + "text": "No therapy exists for halting the progression of the disease with the possible exception of laser photocoagulation treatment used to ablate subretinal neovascular membranes in an attempt to avoid complications of subretinal hemorrhages .", + "entities": [] + }, + { + "id": "7209", + "type": "gene", + "text": "The nucleotide sequence consists of 48 bp of 5 ' - end non - coding region , 1695 bp of coding region and 212 bp of 3 ' - end non - coding region including a 20 bp poly ( A ) tail .", + "entities": [] + }, + { + "id": "7210", + "type": "gene", + "text": "The population of between 75 , 000 and 100 , 000 was largely unstable , and cost per capita was $ 0 . 95 to $ 1 . 21 .", + "entities": [] + }, + { + "id": "7211", + "type": "gene", + "text": "We recently found that 17 beta - estradiol ( E2 ) not only suppresses bone resorption but also stimulates bone formation in the cancellous bone of female rats .", + "entities": [] + }, + { + "id": "7212", + "type": "gene", + "text": "Some of the PCR products contained mutations in ATG1 and / or ATG2 .", + "entities": [ + "ATG1", + "ATG2" + ] + }, + { + "id": "7213", + "type": "gene", + "text": "CONCLUSIONS : The surgical or multimodality treatment of MSGT has provided a good locoregional control ( 78 % ) and 68 % 10 - year survival in a series of patients treated at the oncology department of a general hospital in Quito , Ecuador .", + "entities": [] + }, + { + "id": "7214", + "type": "gene", + "text": "To those of us who are not satisfied with the present outlook there is much to be investigated and much to be contributed .", + "entities": [] + }, + { + "id": "7215", + "type": "gene", + "text": "Riboflavin did not affect the percentage of aflatoxin - treated animals with abnormal urinary excretion patterns , but did increase the magnitude of the disturbances in elimination of kynurenic and xanthurenic acids .", + "entities": [] + }, + { + "id": "7216", + "type": "gene", + "text": "Treatment of 2 patients with pseudohypoparathyroidism type I with vitamin - D - 3 and 1 alpha - Hydroxycholecalciferol consecutively resulted in a nonuniform response with regard to the normalisation of serum - calcium .", + "entities": [] + }, + { + "id": "7217", + "type": "gene", + "text": "Our results indicate that D ( 4 ) and D ( 2L ) receptors activate the ERK kinase cascade by first mobilizing signaling by the PDGF receptor , followed by the subsequent activation of ERK1 / 2 by pathways associated with this receptor tyrosine kinase .", + "entities": [ + "ERK kinase", + "PDGF receptor", + "ERK1 / 2", + "receptor tyrosine kinase" + ] + }, + { + "id": "7218", + "type": "gene", + "text": "Body weight reduction increases insulin sensitivity and improves both blood glucose and blood pressure control .", + "entities": [ + "insulin" + ] + }, + { + "id": "7219", + "type": "gene", + "text": "No consistent correlation between blood pressure change and SCR - change was seen .", + "entities": [] + }, + { + "id": "7220", + "type": "gene", + "text": "Salient applications of PB - PK modeling to toxicological problems are illustrated with examples .", + "entities": [] + }, + { + "id": "7221", + "type": "gene", + "text": "The TIMP ( - 59 / - 53 ) AP1 site is a promiscuous motif that binds c - Fos / c - Jun AP1 translated in vitro and is an effective competitor for binding of nuclear AP1 factors to the consensus TRE , but in addition it binds factors that do not associate with the consensus TRE .", + "entities": [ + "TIMP", + "AP1", + "c - Fos", + "AP1", + "nuclear AP1 factors" + ] + }, + { + "id": "7222", + "type": "gene", + "text": "In protocol 2 , eight different subjects performed Con and Ecc arm curls to fatigue , followed by postexercise muscle ischemia , by using the same resistance as in protocol 1 .", + "entities": [] + }, + { + "id": "7223", + "type": "gene", + "text": "Liver regional blood volume ( LRBV ) is altered by several disease states and various drugs .", + "entities": [] + }, + { + "id": "7224", + "type": "gene", + "text": "In the tissues tested , except brain , the message for CLIP - 170 was more abundant than that for Restin .", + "entities": [ + "CLIP - 170", + "Restin" + ] + }, + { + "id": "7225", + "type": "gene", + "text": "To identify factors that may modify the heterosexual transmission of human T cell leukemia / lymphoma virus type I ( HTLV - I ) , 534 married couples enrolled in the Miyazaki Cohort Study between November 1984 and April 1989 were studied : 95 husband HTLV - I - seropositive ( H + ) / wife seropositive ( W + ) , 33 H + / W - , 64 H - / W + , and 342 H - / W - .", + "entities": [] + }, + { + "id": "7226", + "type": "gene", + "text": "Lack of sufficient data on vibration measurements and employment durations add to the uncertainty , as do variations in tool conditions ( grinder wheels , etc ) and inherent difficulties in measurement .", + "entities": [] + }, + { + "id": "7227", + "type": "gene", + "text": "The prominent lesions were confined to the cerebral surface layer and leptomeningeal tissue including the arachnoid vessels , which were all bathed in the cerebrospinal fluid , suggesting that some necrotizing toxins had been secreted into the fluid by the B . cereus .", + "entities": [] + }, + { + "id": "7228", + "type": "gene", + "text": "Effect of succimer on the intensity of tricarboxylic acid dehydrogenase reactions in the brain of rats poisoned with mercuric chloride", + "entities": [ + "tricarboxylic acid dehydrogenase" + ] + }, + { + "id": "7229", + "type": "gene", + "text": "The antihypertensive effect of Estulic has been examined over a 12 - month period in 101 hypertensive patients .", + "entities": [] + }, + { + "id": "7230", + "type": "gene", + "text": "During this period , administration of additional exogenous PRL did not stimulate further activation ( binding ) of the Stat factors .", + "entities": [ + "exogenous PRL", + "Stat factors" + ] + }, + { + "id": "7231", + "type": "gene", + "text": "This study analyzed whether the localization of an accessory pathway could be predicted by using the polarity of the QRS complex during sinus rhythm on the surface ECG , instead of the delta wave polarity as used in many reports .", + "entities": [] + }, + { + "id": "7232", + "type": "gene", + "text": "Moreover , increasing the dosage of wild - type Fus3 intensifies the inhibition of both Ty1 transposition and invasive growth .", + "entities": [ + "wild - type Fus3", + "Ty1" + ] + }, + { + "id": "7233", + "type": "gene", + "text": "After recovery , a hypertonic saline challenge was performed .", + "entities": [] + }, + { + "id": "7234", + "type": "gene", + "text": "Acoust .", + "entities": [] + }, + { + "id": "7235", + "type": "gene", + "text": "Considering these sources of error some of the variability in the present investigation might be avoided by systematic instructions .", + "entities": [] + }, + { + "id": "7236", + "type": "gene", + "text": "We have mutated to cysteine , one at a time , 21 consecutive residues in the fourth TMS ( TM4 ) .", + "entities": [] + }, + { + "id": "7237", + "type": "gene", + "text": "No case of SMF demonstrated expansive tumorous growth .", + "entities": [] + }, + { + "id": "7238", + "type": "gene", + "text": "Mutants lacking the 3 ' stem - loop exhibited a 75 % reduction in the level of psaB mRNA .", + "entities": [ + "psaB" + ] + }, + { + "id": "7239", + "type": "gene", + "text": "Fulminant hepatitis A in chronic HBV carrier .", + "entities": [] + }, + { + "id": "7240", + "type": "gene", + "text": "The major RNase E cleavage product ( denoted pSok - 6 ) is rapidly degraded by polynucleotide phosphorylase ( PNPase ) .", + "entities": [ + "RNase E", + "pSok - 6", + "polynucleotide phosphorylase", + "PNPase" + ] + }, + { + "id": "7241", + "type": "gene", + "text": "No symptoms other than hot flush showed such significant correlation with plasma epinephrine or norepinephrine levels .", + "entities": [] + }, + { + "id": "7242", + "type": "gene", + "text": "The 5 ' flanking region is highly GC rich , with multiple CpG doublets , and contains multiple binding sites for Sp1 .", + "entities": [ + "Sp1" + ] + }, + { + "id": "7243", + "type": "gene", + "text": "We have cloned a novel mouse protein , TAF ( II ) 140 , containing an HFD and a plant homeodomain ( PHD ) finger , which we demonstrated by immunoprecipitation to be a mammalian TFIID component .", + "entities": [ + "TAF ( II ) 140", + "HFD", + "plant homeodomain", + "PHD", + "mammalian TFIID component" + ] + }, + { + "id": "7244", + "type": "gene", + "text": "However , addition of core DNA polymerase III to preinitiation complex , fully reconstituting holoenzyme resulted in replacement of gamma by alpha at the primer terminus .", + "entities": [ + "core DNA polymerase III" + ] + }, + { + "id": "7245", + "type": "gene", + "text": "We have isolated a new human RING - finger gene ( RNF4 ) that encodes a 190 - amino - acid protein .", + "entities": [ + "human RING - finger gene", + "RNF4" + ] + }, + { + "id": "7246", + "type": "gene", + "text": "Measurement of gastric acid secretion by conductivity .", + "entities": [] + }, + { + "id": "7247", + "type": "gene", + "text": "M . , and D .", + "entities": [] + }, + { + "id": "7248", + "type": "gene", + "text": "Kinetic coupling and requirement for ATP hydrolysis .", + "entities": [] + }, + { + "id": "7249", + "type": "gene", + "text": "Standard reference sources indicate that an able - bodied 11 - year - old child of comparable height requires 1 , 493 kcal / d for support of basal metabolic functions .", + "entities": [] + }, + { + "id": "7250", + "type": "gene", + "text": "The response of the plasma fibrinogen level to the subucutaneous injection of turpentine and to the intravenous injection of endotoxin was measured in normal rabbits and in rabbits made granulocytopenic and thrombocytopenic with busulfan .", + "entities": [ + "plasma fibrinogen" + ] + }, + { + "id": "7251", + "type": "gene", + "text": "A 9 . 5 - kb KpnI - SalI fragment , where all the DNA changes associated with su ( Hw ) mutations were mapped , was able to rescue the su ( Hw ) mutant phenotype after P - element - mediated germ - line transformation .", + "entities": [ + "KpnI", + "SalI", + "su ( Hw ) mutations", + "su ( Hw ) mutant" + ] + }, + { + "id": "7252", + "type": "gene", + "text": "We generated transformed B lymphoblast cell lines from controls , from four patients with p47 - phox - deficient chronic granulomatous disease , and from three parents .", + "entities": [ + "p47", + "phox" + ] + }, + { + "id": "7253", + "type": "gene", + "text": "Thus , these studies on rat Std promoter function indicate that ( i ) HNF1 and C / EBP are responsible for liver specificity of the rat Std gene ; ( ii ) androgenic repression of the gene requires the presence of all of the OCT - 1 and C / EBP elements between positions - 231 and - 292 ; and ( iii ) AR may exert its negative regulatory effect indirectly through transcriptional interference of OCT - 1 and C / EBP rather than through a direct DNA - AR interaction .", + "entities": [ + "rat Std promoter", + "HNF1", + "C / EBP", + "rat Std gene", + "OCT - 1", + "C / EBP elements", + "AR", + "OCT - 1", + "C / EBP", + "DNA - AR" + ] + }, + { + "id": "7254", + "type": "gene", + "text": "They observed depressed protein C activity that significantly ( p < 0 . 005 ) increased and became normal immediately after hemodialysis while factor X and factor VII increased ( p < 0 . 01 ; p < 0 . 05 ) despite heparinization together with amount of serum lipoprotein ( a ) .", + "entities": [ + "protein C", + "factor X", + "factor VII", + "serum lipoprotein ( a )" + ] + }, + { + "id": "7255", + "type": "gene", + "text": "In 10 pentobarbitalized dogs , plasma viscosity ( Ep ) was raised fourfold while apparent blood viscosity ( Ea ) increased about twofold by two steps of exchange transfusion of 200 ml of plasma with plasma containing high molecular weight dextran ( mol wt 500 , 000 , 20 % wt / vol ) .", + "entities": [] + }, + { + "id": "7256", + "type": "gene", + "text": "Because of differences in patient characteristics , control measurements were obtained from normal muscle in all patients .", + "entities": [] + }, + { + "id": "7257", + "type": "gene", + "text": "Analysis of cell cycle regulation in the budding yeast Saccharomyces cerevisiae has shown that a central regulatory protein kinase , Cdc28 , undergoes changes in activity through the cell cycle by associating with distinct groups of cyclins that accumulate at different times .", + "entities": [ + "Cdc28", + "cyclins" + ] + }, + { + "id": "7258", + "type": "gene", + "text": "By comparing the abundances of many yeast transcripts in isogenic wild - type and paf1 mutant strains , we have identified genes whose expression is affected by PAF1 .", + "entities": [ + "paf1 mutant", + "PAF1" + ] + }, + { + "id": "7259", + "type": "gene", + "text": "Fenfluramine ( in doses ranging from 0 . 0625 - 4 . 0 mg / kg / infusion ) did not maintain self - administration behavior at or above the minimum requirement ( FR 30 ) .", + "entities": [] + }, + { + "id": "7260", + "type": "gene", + "text": "Novel 8 - base pair sequence ( Drosophila DNA replication - related element ) and specific binding factor involved in the expression of Drosophila genes for DNA polymerase alpha and proliferating cell nuclear antigen .", + "entities": [ + "DNA polymerase alpha", + "proliferating cell nuclear antigen" + ] + }, + { + "id": "7261", + "type": "gene", + "text": "Isolation of a temperature - sensitive mutant with an altered tRNA nucleotidyltransferase and cloning of the gene encoding tRNA nucleotidyltransferase in the yeast Saccharomyces cerevisiae .", + "entities": [ + "tRNA nucleotidyltransferase", + "gene encoding tRNA nucleotidyltransferase in the yeast Saccharomyces cerevisiae" + ] + }, + { + "id": "7262", + "type": "gene", + "text": "The responsive region of the alpha 2 ( V ) collagen gene was localized to a fragment including 100 bp of basal promoter and 150 bp of exon 1 sequences , which contained two CRE - like elements .", + "entities": [ + "alpha 2 ( V ) collagen gene" + ] + }, + { + "id": "7263", + "type": "gene", + "text": "PIP2 , when incorporated into phosphatidylcholine carrier vesicles , binds tightly to the guanine nucleotide - depleted form of Cdc42Hs and weakly to the GDP - bound form of the GTP - binding protein but does not bind to GTP - bound Cdc42Hs , similar to what was observed for the Dbl oncoprotein .", + "entities": [ + "Cdc42Hs", + "GTP - binding protein", + "Cdc42Hs", + "Dbl oncoprotein" + ] + }, + { + "id": "7264", + "type": "gene", + "text": "Comparison of sequences of ovine and bovine , rat and guinea - pig alpha s1 - casein mRNAs has revealed a greater homology in the 3 ' and especially 5 ' non coding regions .", + "entities": [ + "guinea - pig alpha s1 - casein mRNAs" + ] + }, + { + "id": "7265", + "type": "gene", + "text": "The optimal sequence for interaction with mu 2 and with AP - 2 has tyrosine as an anchor and prefers arginine at position Y + 2 and leucine at position Y + 3 .", + "entities": [ + "mu 2", + "AP - 2" + ] + }, + { + "id": "7266", + "type": "gene", + "text": "The induction of RNKP - 1 expression in the Con A - cultured spleen cells is accompanied by increases in both NK and lymphokine - activated killer lymphocyte activities .", + "entities": [ + "RNKP - 1", + "Con A" + ] + }, + { + "id": "7267", + "type": "gene", + "text": "Alpha - 1 antitrypsin and Indian childhood cirrhosis .", + "entities": [ + "Alpha - 1 antitrypsin" + ] + }, + { + "id": "7268", + "type": "gene", + "text": "The RNA genome of rabbit hemorrhagic disease virus ( RHDV ) was molecularly cloned .", + "entities": [] + }, + { + "id": "7269", + "type": "gene", + "text": "To assess the functional importance of these NBS in the overall drug resistance phenotype conferred by mdr1 , we introduced amino acid substitutions in the core consensus sequence for nucleotide binding , GXGKST .", + "entities": [ + "mdr1" + ] + }, + { + "id": "7270", + "type": "gene", + "text": "The hit1 - 1 mutation caused a defect in synthesis of a 74 - kD heat shock protein .", + "entities": [ + "hit1 - 1", + "74 - kD heat shock protein" + ] + }, + { + "id": "7271", + "type": "gene", + "text": "All other changes at the 3 - , 5 - , and 6 - positions , as well as the replacement of the phenyl group at position 2 , caused a marked decrease of activity .", + "entities": [] + }, + { + "id": "7272", + "type": "gene", + "text": "The levels of transactivation are correlated with the respective binding affinities of the response elements ( IRper - 1 > DR - 4 > IRhsp - 1 ) .", + "entities": [] + }, + { + "id": "7273", + "type": "gene", + "text": "An anchored AFLP - and retrotransposon - based map of diploid Avena .", + "entities": [] + }, + { + "id": "7274", + "type": "gene", + "text": "These data confirm the existence of hyperlipemic abdominal crisis as a distinct entity and testify to the importance of recognizing this syndrome in order to avoid the occurrence of acute pancreatitis and the performance of unnecessary and potentially harmful surgery .", + "entities": [] + }, + { + "id": "7275", + "type": "gene", + "text": "The Siglecs are a subfamily of I - type lectins ( immunoglobulin superfamily proteins that bind sugars ) that specifically recognize sialic acids .", + "entities": [ + "Siglecs", + "I - type lectins", + "immunoglobulin superfamily proteins" + ] + }, + { + "id": "7276", + "type": "gene", + "text": "Information about immunologic drug interactions is needed by pharmacists to make rational drug - use decisions .", + "entities": [] + }, + { + "id": "7277", + "type": "gene", + "text": "The sympathetic neuroeffector influence on the myocardium with ATCI depends to a large measure on the intensity of the neurotransmitter biosynthesis and function of cardiomyocyte adrenoreceptors .", + "entities": [] + }, + { + "id": "7278", + "type": "gene", + "text": "Urinary LTE4 increased after both challenges the rise being higher following oral as compared to inhalation provocation ( p = 0 . 0001 ) .", + "entities": [] + }, + { + "id": "7279", + "type": "gene", + "text": "Digestion of NF - IL6 with endoprotease Asp - N produced a domain smaller than the TCD ( NF - IL6 bZIP domains ( NFBD ) ( 272 - 345 ) ) , a domain identified either in the absence or the presence of DNA .", + "entities": [ + "NF - IL6", + "endoprotease Asp - N", + "TCD", + "NF - IL6 bZIP domains", + "NFBD" + ] + }, + { + "id": "7280", + "type": "gene", + "text": "Thus , as expected , trans - splicing depends on the integrity of U2 , U4 , and U6 snRNAs .", + "entities": [ + "U2", + "U4", + "U6 snRNAs" + ] + }, + { + "id": "7281", + "type": "gene", + "text": "Pit - 1 is a tissue - specific POU domain factor obligatory for the appearance of three cell phenotypes in the anterior pituitary gland .", + "entities": [ + "Pit - 1", + "POU domain factor" + ] + }, + { + "id": "7282", + "type": "gene", + "text": "Based on the sequence of the conRTRE , we located a putative RTRE , referred to as P2 - RE , in the 5 ' promoter - flanking region of the mouse protamine 2 gene , which is induced during the same stage of spermatogenesis as RTR .", + "entities": [ + "conRTRE", + "RTRE", + "P2 - RE", + "mouse protamine 2 gene", + "RTR" + ] + }, + { + "id": "7283", + "type": "gene", + "text": "The bHLH proteins function as potent transcriptional activators of tissue - specific genes by forming heterodimers between ubiquitous and cell - restricted family members .", + "entities": [ + "bHLH proteins" + ] + }, + { + "id": "7284", + "type": "gene", + "text": "The determination of immunoglobulin E ( IgE ) antibodies by one of several laboratory tests , by skin - prick tests or by appropriate challenge procedures is useful either to identify atopic individuals or as outcome predictors in wheezy children .", + "entities": [ + "immunoglobulin E", + "IgE" + ] + }, + { + "id": "7285", + "type": "gene", + "text": "These results provide the first demonstration that an SR protein can influence splicing of specific pre - mRNAs in vivo .", + "entities": [ + "SR protein" + ] + }, + { + "id": "7286", + "type": "gene", + "text": "Only after a pretreatment aimed at increasing its oxide surface layer was titanium powder found to accelerate the precipitation from solutions containing 2 mmol / L CaCl2 , 2 mmol / L KH2PO4 , 50 mmol / L Hepes , pH 7 . 2 , and to induce precipitation from metastable solutions containing 1 . 2 mmol / L CaCl2 , 1 . 2 mmol / L KH2PO4 , 50 mmol / L Hepes , pH 7 . 2 , at 37 degrees C .", + "entities": [] + }, + { + "id": "7287", + "type": "gene", + "text": "Audiological findings in pregnancy .", + "entities": [] + }, + { + "id": "7288", + "type": "gene", + "text": "Irradiation of human blood platelets with UV - A in vitro impairs their ability to aggregate after challenge with collagen .", + "entities": [ + "collagen" + ] + }, + { + "id": "7289", + "type": "gene", + "text": "National certification : a vital component of quality assurance .", + "entities": [] + }, + { + "id": "7290", + "type": "gene", + "text": "One skull does not a species make .", + "entities": [] + }, + { + "id": "7291", + "type": "gene", + "text": "Purple photosynthetic bacteria are capable of generating cellular energy from several sources , including photosynthesis , respiration , and H ( 2 ) oxidation .", + "entities": [] + }, + { + "id": "7292", + "type": "gene", + "text": "The cDNA sequence has an 813 - bp open reading frame ( ORF ) whose predicted amino acid sequence is 97 . 6 % identical to the 272 carboxy - terminal amino acids of the human ets - 1 protein .", + "entities": [ + "human ets - 1 protein" + ] + }, + { + "id": "7293", + "type": "gene", + "text": "The new FIGO definition of cervical cancer stage IA : a critique .", + "entities": [] + }, + { + "id": "7294", + "type": "gene", + "text": "Recurrence of oxalate deposition in a renal transplant during ciclosporin A therapy .", + "entities": [] + }, + { + "id": "7295", + "type": "gene", + "text": "Self - emasculation is the end result of an unusual psychiatric disorder , which initially requires surgical treatment .", + "entities": [] + }, + { + "id": "7296", + "type": "gene", + "text": "The site - directed mutation of the kappa B motif in IL - 6 / CAT plasmid resulted in the complete abrogation of IL - 6 promoter activity in these cells .", + "entities": [ + "kappa B motif", + "IL - 6", + "CAT", + "IL - 6 promoter" + ] + }, + { + "id": "7297", + "type": "gene", + "text": "Crohn ' s disease in prolonged remission : should one augment protein - calorie intake as compared to healthy subjects ? ] The aim of our two year prospective study was to evaluate whether adult Crohn ' s disease patients in prolonged remission ( CDAI < 150 ) , in order to maintain their body weight as close as possible to the ideal one , need a protein - calorie intake higher than the predicted one and that of healthy controls .", + "entities": [] + }, + { + "id": "7298", + "type": "gene", + "text": "Stroop interference : aging effects assessed with the Stroop Color - Word Test .", + "entities": [] + }, + { + "id": "7299", + "type": "gene", + "text": "In contrast to MPc3 , data indicate that the Pc protein M33 does not interact with AF9 .", + "entities": [ + "MPc3", + "M33", + "AF9" + ] + }, + { + "id": "7300", + "type": "gene", + "text": "RESULTS : At latest examination , mean UPDRS II and III scores had improved by 30 % ( on stimulation , off therapy ) with mean 50 % reduction in daily off time .", + "entities": [] + }, + { + "id": "7301", + "type": "gene", + "text": "Western analyses with antisera raised against Lu - ECAM - 1 peptides show that the N - terminal region of the predicted open reading frame is present only in the larger size proteins ( i . e .", + "entities": [ + "Lu - ECAM - 1 peptides" + ] + }, + { + "id": "7302", + "type": "gene", + "text": "These introns belong to the class of nuclear pre - mRNA introns and contain typical 5 ' - and 3 ' - consensus sequences , as well as unique features .", + "entities": [] + }, + { + "id": "7303", + "type": "gene", + "text": "Endorphins at the approach of death .", + "entities": [ + "Endorphins" + ] + }, + { + "id": "7304", + "type": "gene", + "text": "In these vectors the chimeric long terminal repeat ( chLTR ) drives the expression of the chloramphenicol acetyl transferase ( CAT ) reporter gene that is followed by an internal SV40 virus early region promoter linked to the neomycin phosphotransferase II ( NEO ) gene .", + "entities": [ + "chimeric long terminal repeat", + "chLTR", + "chloramphenicol acetyl transferase", + "CAT", + "SV40 virus early region promoter", + "neomycin phosphotransferase II", + "NEO" + ] + }, + { + "id": "7305", + "type": "gene", + "text": "Of 600 mediastinoscopies carried out from 1966 to 1973 , 479 were performed to assess the operability of a pulmonary carcinoma .", + "entities": [] + }, + { + "id": "7306", + "type": "gene", + "text": "This philosophy was instituted for the compound RP 73401 , a specific phosphodiesterase IV inhibitor , that was being developed simultaneously for delivery by both oral and pulmonary routes of administration .", + "entities": [ + "phosphodiesterase IV" + ] + }, + { + "id": "7307", + "type": "gene", + "text": "The 3ASubE cells expressing CXCR2 with mutation of Ser - 346 , - 347 , and - 348 to alanine , or with mutation of only one serine in this domain , continue to be phosphorylated in response to ligand and are 60 - 70 % desensitized following the initial ligand challenge .", + "entities": [ + "CXCR2" + ] + }, + { + "id": "7308", + "type": "gene", + "text": "OBJECTIVE : Although the preponderance of findings offer support for transient ( where is it ? ) as opposed to sustained ( what is it ? ) deficit , a need remains for specific depiction of the deficit .", + "entities": [] + }, + { + "id": "7309", + "type": "gene", + "text": "A value of 1 . 1 l / kg was used for V in calculating all single sample estimates of clearance ( CL ) , and a value of 4 . 3 l / kg was used to calculate single sample estimates of clearance of plasma unbound drug ( CLunb ) .", + "entities": [] + }, + { + "id": "7310", + "type": "gene", + "text": "The effect of crude oil spillage on growth , productivity and nutrient uptake of maize ( Zea mays L . ) was assessed in a pot experiment using an Evwreni manifold sample of a petroleum development company , which had a specific gravity of 0 . 8778 .", + "entities": [] + }, + { + "id": "7311", + "type": "gene", + "text": "Also in the spectrum of mutants with TGN sorting defects are isolates with mutations in the following : RIC1 , encoding a product originally proposed to participate in ribosome biogenesis ; LUV1 , encoding a product potentially involved in vacuole and microtubule organization ; and INP53 , encoding a synaptojanin - like inositol polyphosphate 5 - phosphatase .", + "entities": [ + "RIC1", + "LUV1", + "INP53", + "synaptojanin - like inositol polyphosphate 5 - phosphatase" + ] + }, + { + "id": "7312", + "type": "gene", + "text": "HIV - 1 infection in rural Africa : is there a difference in median time to AIDS and survival compared with that in industrialized countries ?", + "entities": [] + }, + { + "id": "7313", + "type": "gene", + "text": "OBJECTIVES : To describe the progression times of HIV - 1 infection from seroconversion to AIDS and to death , and time from first developing AIDS to death in rural Uganda .", + "entities": [] + }, + { + "id": "7314", + "type": "gene", + "text": "A decrease in insulin - induced receptor kinase activity was observed for solubilized chimeric receptors .", + "entities": [ + "insulin" + ] + }, + { + "id": "7315", + "type": "gene", + "text": "Similar waves were seen on cross - correlating a motor unit with an electronic oscillator , confirming that their occurrence does not necessarily demonstrate the existence of active neural interactions .", + "entities": [] + }, + { + "id": "7316", + "type": "gene", + "text": "Since the early 1980s there has been increasing awareness of the importance of quantifying health - related quality of life ( HRQL ) in patients with chronic respiratory disorders included in clinical trials .", + "entities": [] + }, + { + "id": "7317", + "type": "gene", + "text": "We found that the amplitude of the cortical evoked potentials ( amplitude of the N2 / P2 peak ) increased from 5 . 1 + / - 0 . 7 microV at 5 mA to 16 . 3 + / - 1 . 1 microV at 20 mA .", + "entities": [] + }, + { + "id": "7318", + "type": "gene", + "text": "Karger AG , Basel", + "entities": [] + }, + { + "id": "7319", + "type": "gene", + "text": "In addition a significant Treatment X Strain interaction was due to the larger defecation numbers displayed by the taurine - injected MR rats relative to the saline - injected MR rats .", + "entities": [] + }, + { + "id": "7320", + "type": "gene", + "text": "The SUP44 suppressor mutation occurs near a region of the protein that corresponds to the known positions of alterations in E . coli S5 ram mutations .", + "entities": [ + "SUP44 suppressor mutation", + "E . coli S5 ram mutations" + ] + }, + { + "id": "7321", + "type": "gene", + "text": "Interferon - alpha may exacerbate cryoblobulinemia - related ischemic manifestations : an adverse effect potentially related to its anti - angiogenic activity .", + "entities": [ + "Interferon - alpha" + ] + }, + { + "id": "7322", + "type": "gene", + "text": "Interferon - alpha may exacerbate cryoblobulinemia - related ischemic manifestations : an adverse effect potentially related to its anti - angiogenic activity .", + "entities": [ + "Interferon - alpha" + ] + }, + { + "id": "7323", + "type": "gene", + "text": "The December armed revolt in Moscow and the paramedical personnel", + "entities": [] + }, + { + "id": "7324", + "type": "gene", + "text": "By negatively regulating GRK - mediated receptor phosphorylation , beta - arrestin - mediated processes such as Src recruitment and clathrin - mediated internalization , which are required for GPCR - mediated ERK activation , are inhibited , thus dampening further ERK activation .", + "entities": [ + "GRK", + "beta - arrestin", + "Src", + "clathrin", + "GPCR", + "ERK", + "ERK" + ] + }, + { + "id": "7325", + "type": "gene", + "text": "GnRH treatment was found to increase the phosphorylation of tyrosine residues of MAPK and to increase MAPK activity , as determined by an immune complex kinase assay .", + "entities": [ + "GnRH", + "MAPK", + "MAPK" + ] + }, + { + "id": "7326", + "type": "gene", + "text": "In this paper we describe properties of the cdc10 - C4 mutant of the fission yeast Schizosaccharomyces pombe .", + "entities": [ + "cdc10" + ] + }, + { + "id": "7327", + "type": "gene", + "text": "Glutathione S - transferase ( GST ) - E2F and GST - DP fusion proteins were found to cooperate in binding to the three E2F sites in the DNA polymerase alpha gene promoter in vitro .", + "entities": [ + "Glutathione S - transferase", + "GST", + "E2F", + "GST", + "DP", + "E2F sites", + "DNA polymerase alpha gene promoter" + ] + }, + { + "id": "7328", + "type": "gene", + "text": "The complete exon - intron structure of the 156 - kb human gene NFKB1 , which encodes the p105 and p50 proteins of transcription factors NF - kappa B and I kappa B - gamma : implications for NF - kappa B - mediated signal transduction .", + "entities": [ + "156 - kb human gene NFKB1", + "p105", + "p50 proteins", + "NF - kappa B", + "I kappa B - gamma", + "NF - kappa B" + ] + }, + { + "id": "7329", + "type": "gene", + "text": "The risk factors for hematuria in patients with renal hypouricemia are the elevation of urinary urate concentration and the subtypes of Post and Secretion .", + "entities": [] + }, + { + "id": "7330", + "type": "gene", + "text": "The effects of oral vanadyl sulfate ( VOSO4 ) ( 0 . 5 mg / kg / day ) on anthropometry , body composition , and performance were investigated in a 12 - week , double - blind , placebo - controlled trial involving weight - training volunteers .", + "entities": [] + }, + { + "id": "7331", + "type": "gene", + "text": "Molecular cloning of a cDNA encoding rat NADH - cytochrome b5 reductase and the corresponding gene .", + "entities": [ + "rat NADH - cytochrome b5 reductase" + ] + }, + { + "id": "7332", + "type": "gene", + "text": "This gene spans 23 kb and is composed of five exons and four introns .", + "entities": [] + }, + { + "id": "7333", + "type": "gene", + "text": "Identification of five new genes , closely related to the interleukin - 1beta converting enzyme gene , that do not encode functional proteases .", + "entities": [ + "interleukin - 1beta converting enzyme gene" + ] + }, + { + "id": "7334", + "type": "gene", + "text": "These overall results indicate that there is generally one PERV copy per integration site .", + "entities": [] + }, + { + "id": "7335", + "type": "gene", + "text": "Clinical method for the treatment of Class II occlusal anomalies with open bite", + "entities": [] + }, + { + "id": "7336", + "type": "gene", + "text": "However , unlike Bcl - 2 and the E1B 19K proteins , which completely block apoptosis but not p53 - dependent growth arrest , H - ras expression permitted DNA synthesis and cell proliferation in the presence of high levels of wild - type p53 .", + "entities": [ + "Bcl - 2", + "E1B 19K proteins", + "p53", + "H - ras", + "wild - type p53" + ] + }, + { + "id": "7337", + "type": "gene", + "text": "Dynamic imaging of nuclear wave functions with ultrashort UV laser pulses .", + "entities": [] + }, + { + "id": "7338", + "type": "gene", + "text": "Three separate activation subdomains , and one negative - acting region , which function in yeast were located in the carboxyl - terminal region of NIT4 .", + "entities": [ + "NIT4" + ] + }, + { + "id": "7339", + "type": "gene", + "text": "Polyglactin 910 suture absorption and the role of cellular enzymes .", + "entities": [] + }, + { + "id": "7340", + "type": "gene", + "text": "These data provide evidence that the 2 . 0 - kb LAT is an intron of the mLAT pre - mRNA with a unique branch point .", + "entities": [ + "2 . 0 - kb LAT", + "mLAT pre - mRNA" + ] + }, + { + "id": "7341", + "type": "gene", + "text": "All subsequent patients were treated at the maximal tolerated dose of EDXR ( 35 mg / m2 / day ) .", + "entities": [] + }, + { + "id": "7342", + "type": "gene", + "text": "The primer is generated by a cleavage that occurs between bases 11 and 12 of the Tf1 mRNA .", + "entities": [ + "Tf1 mRNA" + ] + }, + { + "id": "7343", + "type": "gene", + "text": "An exaggerated tissue response adjacent to the cyanoacrylate site suggested a potential toxic chemical or thermal reaction , or both , to the tissue adhesive , but there was no evidence of any distant ocular effects .", + "entities": [] + }, + { + "id": "7344", + "type": "gene", + "text": "The activation of the HIV promoter required the nuclear localization of c - Abl and could be correlated with increased tyrosine phosphorylation of RNA polymerase II .", + "entities": [ + "c - Abl", + "RNA polymerase II" + ] + }, + { + "id": "7345", + "type": "gene", + "text": "The purpose of this study was to evaluate simplified methods for estimation of Technetium Tc 99m ( 99mTc ) - pentetate and orthoiodohippurate I 131 ( 131I - OIH ) plasma clearance in dogs and cats with 1 and 2 blood samples .", + "entities": [] + }, + { + "id": "7346", + "type": "gene", + "text": "Intracellular pH , H ion flux and H ion permeability coefficient in bullfrog toe muscle .", + "entities": [] + }, + { + "id": "7347", + "type": "gene", + "text": "These results indicate that CSFHU can increase neutrophil counts by increasing the number and maturity of the marrow neutrophil precursors in some types of childhood chronic neutropenia .", + "entities": [ + "CSFHU" + ] + }, + { + "id": "7348", + "type": "gene", + "text": "In the Rett syndrome we , therefore , suspect there are disturbances in the brain stem functions especially in the ascending reticular activating system which is related to elevation of the conscious level .", + "entities": [] + }, + { + "id": "7349", + "type": "gene", + "text": "The JS78 mutation changes Gln243 in gp0 . 7 to an amber codon , which explains the production of the truncated , 30 - kDa gp0 . 7 - related polypeptide , and implicates the 11 - kDa C - terminal domain in host transcription shut - off .", + "entities": [ + "30 - kDa gp0 . 7 - related polypeptide" + ] + }, + { + "id": "7350", + "type": "gene", + "text": "In contrast , we did not detect a significant correlation between plasma TNFalpha and radiation pneumonitis .", + "entities": [ + "plasma TNFalpha" + ] + }, + { + "id": "7351", + "type": "gene", + "text": "Value of the EMG in the diagnosis of a cardiomyopathy associated with a myotonic myopathy .", + "entities": [] + }, + { + "id": "7352", + "type": "gene", + "text": "Cost - effectiveness analysis provides a rational means of allocating limited health care resources by allowing the comparison of the costs of lipid - lowering therapy , in particular , therapy with beta - hydroxy - beta - methylglutaryl - CoA ( coenzyme A ) reductase inhibitors ( statins ) , with the costs of atherosclerosis that could be prevented by lowering cholesterol .", + "entities": [ + "beta - hydroxy - beta - methylglutaryl - CoA ( coenzyme A ) reductase" + ] + }, + { + "id": "7353", + "type": "gene", + "text": "Copper treatments were assigned to simulate the different levels of copper intake that might result from differences in daily feed intake similar to the practice followed with commercial industry .", + "entities": [] + }, + { + "id": "7354", + "type": "gene", + "text": "Functional analysis of the sGTH alpha subunit promoter by the transient transfection of several sGTH alpha / CAT chimeric plasmids into rainbow trout pituitary cells suggests that its pituitary - specific expression is GSE - dependent .", + "entities": [ + "sGTH alpha subunit promoter", + "sGTH alpha", + "CAT", + "GSE" + ] + }, + { + "id": "7355", + "type": "gene", + "text": "Transfection studies also showed that 3 ' - deletion of sequences downstream of the transcriptional start site ( + 1 / + 47 ) markedly reduced OSM - fold induction .", + "entities": [ + "OSM" + ] + }, + { + "id": "7356", + "type": "gene", + "text": "Intrathecal acetyl cholinesterase inhibitors produce analgesia that is synergistic with morphine and clonidine in rats .", + "entities": [ + "acetyl cholinesterase" + ] + }, + { + "id": "7357", + "type": "gene", + "text": "The murine int - 6 locus , identified as a frequent integration site of mouse mammary tumor viruses , encodes the 48 - kDa eIF3e subunit of translation initiation factor eIF3 .", + "entities": [ + "murine int - 6 locus", + "48 - kDa eIF3e subunit of translation initiation factor eIF3" + ] + }, + { + "id": "7358", + "type": "gene", + "text": "We examined the binding of purified T3 receptor alpha ( T3R alpha ) , overexpressed in Escherichia coli , to wild - type and up and down mutations of the rGH T3RE to evaluate whether transcriptional potency correlates with changes in T3R binding .", + "entities": [ + "T3 receptor alpha", + "T3R alpha", + "T3RE", + "T3R" + ] + }, + { + "id": "7359", + "type": "gene", + "text": "RESULTS : The LV maximum brightness and area under the curve showed significant negative correlations ( p = < 0 . 004 ) with the FIO2 , while the minimum brightness showed a significant positive correlation ( p = < 0 . 002 ) .", + "entities": [] + }, + { + "id": "7360", + "type": "gene", + "text": "Herein PPARgamma , liganded by either natural ( 15d - PGJ ( 2 ) and PGD ( 2 ) ) or synthetic ligands ( BRL49653 and troglitazone ) , selectively inhibited expression of the cyclin D1 gene .", + "entities": [ + "PPARgamma", + "cyclin D1 gene" + ] + }, + { + "id": "7361", + "type": "gene", + "text": "Therefore , the strD and strE genes could serve as universal probes indicative of the presence of biosynthetic capacity for 6 - deoxyhexose moieties .", + "entities": [ + "strD", + "strE genes" + ] + }, + { + "id": "7362", + "type": "gene", + "text": "In the region Walgau with mixed industrial - rural population an iodine deficiency I was found in 81 % and an iodine deficiency II in 45 % .", + "entities": [] + }, + { + "id": "7363", + "type": "gene", + "text": "CONCLUSIONS : In healthy individuals , whole body insulin sensitivity is related , or \" coupled , \" to the anaerobic threshold .", + "entities": [ + "insulin" + ] + }, + { + "id": "7364", + "type": "gene", + "text": "DATA SYNTHESIS : Intracoronary ultrasound has been shown to improve upon demonstrated weaknesses of coronary angiography .", + "entities": [] + }, + { + "id": "7365", + "type": "gene", + "text": "ATX , like PC - 1 , was found to hydrolyze the type I phosphodiesterase substrate p - nitrophenyl thymidine - 5 ' - monophosphate .", + "entities": [ + "ATX", + "PC - 1", + "type I phosphodiesterase" + ] + }, + { + "id": "7366", + "type": "gene", + "text": "An alternatively spliced MAdCAM - 1 variant was identified that lacks exon 4 encoding the mucin domain , and may mediate leukocyte adhesion to LPAM - 1 without adhesion to the alternate receptor , L - selectin .", + "entities": [ + "MAdCAM - 1", + "mucin", + "LPAM - 1", + "L - selectin" + ] + }, + { + "id": "7367", + "type": "gene", + "text": "MKK3 autophosphorylation and activation of p38 was also observed following coexpression of MKK3 with MEKK3 , but not with MEKK2 .", + "entities": [ + "MKK3", + "p38", + "MKK3", + "MEKK3", + "MEKK2" + ] + }, + { + "id": "7368", + "type": "gene", + "text": "Assay of urea by immobilized urease coupled to a differential pH - meter .", + "entities": [ + "urease" + ] + }, + { + "id": "7369", + "type": "gene", + "text": "Observers with brain injury and control participants performed a vigilance task during which they received periodic whiffs of unscented air or air scented with peppermint .", + "entities": [] + }, + { + "id": "7370", + "type": "gene", + "text": "An electrophoretic mobility shift assay was performed to characterize the binding property of TR2 and its truncated isoform .", + "entities": [ + "TR2" + ] + }, + { + "id": "7371", + "type": "gene", + "text": "Nonreplicating vaccinia vector efficiently expresses recombinant genes .", + "entities": [] + }, + { + "id": "7372", + "type": "gene", + "text": "Recurrent arterial thrombotic disease on young onset and protein S deficiency .", + "entities": [ + "protein S" + ] + }, + { + "id": "7373", + "type": "gene", + "text": "The distal portion of the rat insulin I gene 5 ' - flanking DNA contains two sequence elements , the Far and FLAT elements , that can function in combination , but not separately , as a beta - cell - specific transcriptional enhancer .", + "entities": [ + "rat insulin I gene 5 ' - flanking DNA" + ] + }, + { + "id": "7374", + "type": "gene", + "text": "These studies suggest that MAPK acts by stimulating AP - 1 and a subsequent physical and functional interaction of AP - 1 with NF - kappaB , resulting in a complex that synergistically transactivates the HIV - 1 LTR .", + "entities": [ + "MAPK", + "AP - 1", + "AP - 1", + "NF - kappaB", + "HIV - 1 LTR" + ] + }, + { + "id": "7375", + "type": "gene", + "text": "Analysis of the intact hGH gene or hGH 5 ' - flanking DNA ( 5 ' - FR ) coupled to the hGh cDNA or chloramphenicol acetyltransferase or luciferase genes , indicated that cAMP primarily stimulated hGH promoter activity .", + "entities": [ + "hGH gene", + "hGH 5 ' - flanking DNA ( 5 ' - FR )", + "hGh cDNA", + "chloramphenicol acetyltransferase", + "luciferase genes", + "hGH promoter" + ] + }, + { + "id": "7376", + "type": "gene", + "text": "The availability of potent regulatory DNA cassettes harboring the murine D1A gene promoter could aid testing the neuronal - specific expression of transgenes in vivo .", + "entities": [ + "murine D1A gene promoter" + ] + }, + { + "id": "7377", + "type": "gene", + "text": "The data indicate that Bmp2 is directly regulated by retinoic acid - bound receptors and Sp1 .", + "entities": [ + "Bmp2", + "Sp1" + ] + }, + { + "id": "7378", + "type": "gene", + "text": "Oleate induced steady - state levels of M - CPT I mRNA 4 . 5 - fold .", + "entities": [ + "M - CPT I mRNA" + ] + }, + { + "id": "7379", + "type": "gene", + "text": "Additional education and research is needed to provide further direction for intervention and incorporation into practice .", + "entities": [] + }, + { + "id": "7380", + "type": "gene", + "text": "These studies serve as the basis for the further characterization of the regulatory mechanism of aromatase expression in human breast cancer and ASCs .", + "entities": [ + "aromatase" + ] + }, + { + "id": "7381", + "type": "gene", + "text": "Promoter activity was dose - dependently inhibited by cotransfection with either ras or mos oncogenes , but oncogene inhibition was reversed and the overall activity increased when cells were treated with the MAP kinase kinase ( MKK ) inhibitor PD98059 .", + "entities": [ + "ras", + "mos oncogenes", + "MAP kinase kinase", + "MKK" + ] + }, + { + "id": "7382", + "type": "gene", + "text": "These fusions are contained on plasmids which have both yeast and E . coli replication origins and selectable markers and , therefore , can be used to transform either yeast or E . coli cells .", + "entities": [] + }, + { + "id": "7383", + "type": "gene", + "text": "During chronic treatment , when plasma concentrations fluctuated between 23 . 5 ng . ml - 1 at 8 h and 14 ng . ml - 1 at 24 h post - dosing , ST segment depression at an individually comparable workload was significantly decreased by 28 % compared with placebo ( P < 0 . 005 ) at both points in time .", + "entities": [] + }, + { + "id": "7384", + "type": "gene", + "text": "Feed intake was not affected by dietary KCl or NaHCO3 supplementation , but average daily gain increased with increased K and tended to be reduced by dietary NaHCO3 .", + "entities": [] + }, + { + "id": "7385", + "type": "gene", + "text": "Each expressed domain , as well as FKBP - 33 itself , possesses peptidyl - prolyl cis - trans isomerase activity , though with much lower specific activities than FKBP - 12 .", + "entities": [ + "FKBP - 33", + "peptidyl - prolyl cis - trans isomerase", + "FKBP - 12" + ] + }, + { + "id": "7386", + "type": "gene", + "text": "We conclude that the ' morning dip ' observed in asthmatic patients cannot simply be explained by changes in cell receptor number or affinity , as our results suggest that both groups have intact beta - adrenoceptor function .", + "entities": [ + "beta - adrenoceptor" + ] + }, + { + "id": "7387", + "type": "gene", + "text": "Mono - ADP - ribosylation is a reversible modification of proteins , with NAD : arginine ADP - ribosyltransferases ( EC 2 . 4 . 2 . 31 ) and ADP - ribosylarginine hydrolases ( EC 3 . 2 . 2 . 19 ) catalyzing the opposing reactions in an ADP - ribosylation cycle .", + "entities": [ + "arginine ADP - ribosyltransferases", + "EC 2 . 4 . 2 . 31", + "ADP - ribosylarginine hydrolases", + "EC 3 . 2 . 2 . 19" + ] + }, + { + "id": "7388", + "type": "gene", + "text": "These children were grouped into four diagnostic categories : 1 ) idiopathic GH deficiency ( n = 10 ) ; 2 ) organic hypopituitarism ( n = 7 ) ; 3 ) intrauterine growth retardation ( n = 5 ) ; and 4 ) constitutional delay of growth and / or familial short stature ( n = 18 ) , by standard clinical criteria and physiological and pharmacological tests of GH reserve .", + "entities": [ + "GH", + "GH" + ] + }, + { + "id": "7389", + "type": "gene", + "text": "After dopamine infusion in women with polycystic ovary syndrome and in matched controls , steady state levels of plasma dopamine , norepinephrine , and the ratio of dopamine / norepinephrine were similar in the two groups .", + "entities": [] + }, + { + "id": "7390", + "type": "gene", + "text": "Three missense mutants in subunit a of the Escherichia coli F1F0 - ATPase were isolated and characterized after hydroxylamine mutagenesis of a plasmid carrying the uncB ( subunit a ) gene .", + "entities": [ + "Escherichia coli F1F0 - ATPase", + "uncB ( subunit a ) gene" + ] + }, + { + "id": "7391", + "type": "gene", + "text": "Thus , despite the potential for common regulatory mechanisms , the available evidence indicates that the Mtx minimal promoter does not significantly affect Thbs3 gene expression .", + "entities": [ + "Mtx minimal promoter", + "Thbs3 gene" + ] + }, + { + "id": "7392", + "type": "gene", + "text": "We have isolated a new , larger rat B - myc genomic clone .", + "entities": [ + "rat B - myc genomic clone" + ] + }, + { + "id": "7393", + "type": "gene", + "text": "On d 112 , progesterone was higher ( P less than . 05 ) in hysterectomized heifers than in other treatment groups .", + "entities": [] + }, + { + "id": "7394", + "type": "gene", + "text": "39 - 47 .", + "entities": [] + }, + { + "id": "7395", + "type": "gene", + "text": "The SV40 enhancer augmented replication 1 . 5 - 10 fold .", + "entities": [ + "SV40 enhancer" + ] + }, + { + "id": "7396", + "type": "gene", + "text": "Such a concept is crucial to our understanding of the pathology of ageing in general .", + "entities": [] + }, + { + "id": "7397", + "type": "gene", + "text": "Rapid detection of this mutation is achieved by restriction digestion of PCR - amplified genomic DNA ; a mismatch primer combined with the point mutation creates a Tru9I restriction site .", + "entities": [ + "Tru9I restriction site" + ] + }, + { + "id": "7398", + "type": "gene", + "text": "Differences in the clinical presentation and the gross appearance of the two cases are described , and similarities in the microscopic features are discussed .", + "entities": [] + }, + { + "id": "7399", + "type": "gene", + "text": "Histopathology and pathogenesis of exanthematous viroses", + "entities": [] + }, + { + "id": "7400", + "type": "gene", + "text": "By contrast , d ( T2AG3T ) and d ( T2G4T ) form only the G - quadruplex monomer structures independent of K cation concentration as reported previously [ Sen , D . , & Gilbert , W .", + "entities": [ + "d ( T2AG3T )", + "d ( T2G4T )" + ] + }, + { + "id": "7401", + "type": "gene", + "text": "Refractory periods of the AV junction were altered in a comparable fashion to conduction through the AV node .", + "entities": [] + }, + { + "id": "7402", + "type": "gene", + "text": "We have designated the protein \" cellular NBP \" ( CNBP ) .", + "entities": [ + "\" cellular NBP \"", + "CNBP" + ] + }, + { + "id": "7403", + "type": "gene", + "text": "Helicobacter pylori and stomach diseases : from clinical point of view", + "entities": [] + }, + { + "id": "7404", + "type": "gene", + "text": "Our results suggest that protein binding to the E2F - like sequences may act to reduce expression .", + "entities": [ + "E2F - like sequences" + ] + }, + { + "id": "7405", + "type": "gene", + "text": "To explore the functional properties of the protein encoded by neu , we created a fusion gene that joins the cytoplasmic domain of neu to the extracellular portion of an immunoglobulin heavy chain .", + "entities": [ + "neu", + "neu", + "immunoglobulin heavy chain" + ] + }, + { + "id": "7406", + "type": "gene", + "text": "Range behavior of Hereford , Hereford x Holstein and Holstein non - lactating heifers .", + "entities": [] + }, + { + "id": "7407", + "type": "gene", + "text": "Yang and H .", + "entities": [] + }, + { + "id": "7408", + "type": "gene", + "text": "The non - homologous sequences in the 5 ' untranslated regions might be acquired at or after transcription during retrotransposition of the ATLN elements .", + "entities": [] + }, + { + "id": "7409", + "type": "gene", + "text": "A leucine zipper domain of the suppressor of Hairy - wing protein mediates its repressive effect on enhancer function .", + "entities": [ + "suppressor of Hairy - wing protein" + ] + }, + { + "id": "7410", + "type": "gene", + "text": "Like humans , the PITSLRE PK genes in chickens must be closely linked , based on fluorescent in situ hybridization ( FISH ) localization of these genes to a single chicken microchromosome .", + "entities": [ + "PITSLRE PK genes in chickens" + ] + }, + { + "id": "7411", + "type": "gene", + "text": "On a separate occasion the T1 weighted and T2 weighted sagittal and T2 weighted axial sequences were reported blind in relation to the initial assessment .", + "entities": [] + }, + { + "id": "7412", + "type": "gene", + "text": "This prospective study compared the measured energy expenditures of 30 patients using indirect calorimetry with their predicted basal energy expenditure according to the Harris - Benedict equation , or their calculated energy expenditure derived from basal energy expenditure times , an activity factor , and a stress factor .", + "entities": [] + }, + { + "id": "7413", + "type": "gene", + "text": "Sequence comparison of cytochromes bd and their homologs from various organisms demonstrates that the proteins can be classified into two subfamilies , a proteobacterial type including E . coli bd and a more widely distributed type including the B . stearothermophilus enzyme , suggesting that the latter type is evolutionarily older .", + "entities": [ + "cytochromes bd", + "E . coli bd" + ] + }, + { + "id": "7414", + "type": "gene", + "text": "Apparent loss of differentiation markers characterizes advanced malignant neoplasms .", + "entities": [] + }, + { + "id": "7415", + "type": "gene", + "text": "In 10 patients with subacute cardiac tamponade , pulmonary wedge pressure ( PWP ) , RAP , and IPP were measured along with indexes of systolic function .", + "entities": [] + }, + { + "id": "7416", + "type": "gene", + "text": "In conclusion , NF - Y and Sp1 binding sites play a decisive role in the basal expression of the rat mrp2 gene , while the human MRP2 gene is regulated differently .", + "entities": [ + "NF - Y", + "Sp1", + "rat mrp2 gene", + "human MRP2 gene" + ] + }, + { + "id": "7417", + "type": "gene", + "text": "Re - examination of the ED01 study .", + "entities": [] + }, + { + "id": "7418", + "type": "gene", + "text": "Diary .", + "entities": [] + }, + { + "id": "7419", + "type": "gene", + "text": "Effect of thrombotic and antithrombotic drugs on the surface charge characteristics of canine blood vessels : in vivo and in vitro studies .", + "entities": [] + }, + { + "id": "7420", + "type": "gene", + "text": "The mechanisms that govern the activation or suppression of the CD8 gene are likely to be central to the T cell development program .", + "entities": [ + "CD8 gene" + ] + }, + { + "id": "7421", + "type": "gene", + "text": "It was shown by transient expression assay that HS - 40 behaved as an authentic enhancer for high - level zeta 2 globin promoter activity in K562 cells , an erythroid cell line of embryonic and / or fetal origin .", + "entities": [ + "HS - 40", + "zeta 2 globin promoter" + ] + }, + { + "id": "7422", + "type": "gene", + "text": "Since very recent scanning - deletion analysis indicates that there is a critical region for activity near Cys - 118 and that Cys - 118 is necessary for maximal activity , we conclude that the Cys - 118 residue is necessary for proper glycosylation and maximal biologic activity of GM - CSF .", + "entities": [ + "GM - CSF" + ] + }, + { + "id": "7423", + "type": "gene", + "text": "A prospective trial was carried out in 156 unselected patients ( 41 men , mean age 67 . 5 years , 115 women , mean age 71 . 4 years ) who had undergone total hip joint replacement because of degenerative or inflammatory arthritis or fracture of the neck of the femur .", + "entities": [] + }, + { + "id": "7424", + "type": "gene", + "text": "In contrast , a Maf - related protein , Nrl , completely mimicked c - Maf actions .", + "entities": [ + "Maf - related protein", + "Nrl", + "c - Maf" + ] + }, + { + "id": "7425", + "type": "gene", + "text": "Blood platelets , coagulation factors and morphologic organ changes following scalding shock in rhesus monkeys", + "entities": [] + }, + { + "id": "7426", + "type": "gene", + "text": "Managing dysphagia in a chronic care setting : an introduction .", + "entities": [] + }, + { + "id": "7427", + "type": "gene", + "text": "The C2C - Prx is encoded as a preprotein of 273 amino acids containing a putative chloroplast - targeting signal of 65 amino acids at its N - terminus .", + "entities": [ + "C2C", + "Prx" + ] + }, + { + "id": "7428", + "type": "gene", + "text": "A major mechanism whereby steroid hydroxylase gene transcription is regulated in the adrenal cortex requires the pituitary peptide hormone , ACTH , which acts via cAMP .", + "entities": [ + "steroid hydroxylase gene", + "ACTH" + ] + }, + { + "id": "7429", + "type": "gene", + "text": "Insulin - like growth factor II ( IGFII ) is a mitogenic polypeptide , the mRNAs of which are present in multiple forms , despite derivation from a single gene .", + "entities": [ + "Insulin - like growth factor II", + "IGFII" + ] + }, + { + "id": "7430", + "type": "gene", + "text": "HS inducibility required the HSE which was bound by HS transcription factor - 1 ( HSF - 1 ) present in extracts prepared from cells exposed to HS .", + "entities": [ + "HS transcription factor - 1", + "HSF - 1" + ] + }, + { + "id": "7431", + "type": "gene", + "text": "The deduced protein sequence was 88 % homologous to that of hNUC I , isolated from human osteosarcoma cells .", + "entities": [ + "hNUC I" + ] + }, + { + "id": "7432", + "type": "gene", + "text": "An additional advantage is that the resin can be removed and the immunoperoxidase technique carried out on thin sections .", + "entities": [ + "immunoperoxidase" + ] + }, + { + "id": "7433", + "type": "gene", + "text": "COGLAB includes measures of preattentional , attentional , conceptual , and psychomotor performance .", + "entities": [] + }, + { + "id": "7434", + "type": "gene", + "text": "We isolated a complementary DNA ( cDNA ) clone from an RL95 - 2 expression library that encodes the C1 site - binding protein .", + "entities": [ + "C1 site - binding protein" + ] + }, + { + "id": "7435", + "type": "gene", + "text": "Here , we evidence that the developmental functions of the family of transcription factors characterized by the POU DNA binding motif exerts roles in mammalian development .", + "entities": [ + "POU DNA binding motif" + ] + }, + { + "id": "7436", + "type": "gene", + "text": "The expression of the gene encoding the enzyme ( CYP19 ) is regulated , in part , by tissue - specific promoters through the use of alternative - splicing mechanisms .", + "entities": [ + "CYP19" + ] + }, + { + "id": "7437", + "type": "gene", + "text": "Under these conditions , transfections with cDNAs of the NF - kappa B p50 and serum response factor ( SRF ) produced a factor ( s ) that mediated Tax binding to the NF - kappa B site and the CArG box respectively .", + "entities": [ + "p50", + "serum response factor", + "SRF", + "Tax", + "NF - kappa B site" + ] + }, + { + "id": "7438", + "type": "gene", + "text": "In addition , 5 ' deletions removing all but 34 bp upstream of the transcription start point retained greater than 90 % promoter activity , suggesting that the - 35 hexamer was not essential for promoter activity .", + "entities": [] + }, + { + "id": "7439", + "type": "gene", + "text": "Patients enrolled in the Integrilin to Minimize Platelet Aggregation and Coronary Thrombosis - II ( IMPACT - II ) trial were analyzed .", + "entities": [] + }, + { + "id": "7440", + "type": "gene", + "text": "Four patients ( group 1 ) had type I basement membrane nephropathy , characterized by marked thickening and lamellation of the basement membrane in a pattern resembling that of Alport ' s syndrome .", + "entities": [] + }, + { + "id": "7441", + "type": "gene", + "text": "With the exception of virus assay and quantitation , these methods are simple and inexpensive enough to be done in typical shellfish microbiology laboratories .", + "entities": [] + }, + { + "id": "7442", + "type": "gene", + "text": "The beta subunit of the Fc epsilon R1 is a 33 - kDa tyrosine phosphoprotein , but the p33 Grb2 - binding protein described in the present report is not the Fc epsilon R1 beta chain and its identity is unknown .", + "entities": [ + "Fc epsilon R1", + "Grb2 - binding protein", + "Fc epsilon R1 beta chain" + ] + }, + { + "id": "7443", + "type": "gene", + "text": "A Y . lipolytica Kar2p mutant was isolated that restored interaction with an Sls1p mutant , suggesting that the interaction with Sls1p could be nucleotide and / or conformation dependent .", + "entities": [ + "Y . lipolytica Kar2p mutant", + "Sls1p mutant", + "Sls1p" + ] + }, + { + "id": "7444", + "type": "gene", + "text": "Retinoid - dependent activation of the tissue transglutaminase promoter depends on both a proximal regulatory region containing sequences highly conserved between the human and the mouse tissue transglutaminase promoters and a distal region that includes a 30 - base pair retinoid response element ( mTGRRE1 ) .", + "entities": [ + "tissue transglutaminase promoter", + "mouse tissue transglutaminase promoters" + ] + }, + { + "id": "7445", + "type": "gene", + "text": "mTGRRE1 contains three hexanucleotide half - sites ( two canonical and one non - canonical ) in a DR7 / DR5 motif that bind both RAR * RXR heterodimers and RXR homodimers .", + "entities": [ + "DR7", + "DR5", + "RAR", + "RXR", + "RXR homodimers" + ] + }, + { + "id": "7446", + "type": "gene", + "text": "The arginyl peptide bonds that are cleaved in the conversion of human factor IX to factor IXa by factor XIa were identified as Arg145 - Ala146 and Arg180 - Val181 .", + "entities": [ + "human factor IX", + "factor IXa", + "factor XIa" + ] + }, + { + "id": "7447", + "type": "gene", + "text": "Four short nucleotide sequences ( boxes I to IV ) contribute to the light responsiveness of the parsley chalcone synthase promoter .", + "entities": [ + "parsley chalcone synthase promoter" + ] + }, + { + "id": "7448", + "type": "gene", + "text": "CONCLUSION : Monitoring SpO2 at the nasal septum site is more reliable than monitoring it at the finger site in hypothermic patients .", + "entities": [] + }, + { + "id": "7449", + "type": "gene", + "text": "The swa2 - 1 allele recovered from the original screen carries a point mutation in its tetratricopeptide repeat ( TPR ) domain , a motif not found in auxilin but known in other proteins to mediate interaction with heat - shock proteins .", + "entities": [ + "swa2 - 1 allele", + "auxilin", + "heat - shock proteins" + ] + }, + { + "id": "7450", + "type": "gene", + "text": "The Community Adjustment Scale provided outcome data related to the subjects ' degree of productivity , ability to maintain close relationships , and presence / absence of symptomatology an average of 32 years after initial admission .", + "entities": [] + }, + { + "id": "7451", + "type": "gene", + "text": "Further studies established that the Ep - induced increase in beta - globin mRNA could be inhibited by the tyrosine kinase inhibitor genistein and the protein kinase C inhibitor Compound 3 . ( ABSTRACT TRUNCATED AT 250 WORDS )", + "entities": [ + "Ep", + "beta - globin mRNA", + "tyrosine kinase", + "protein kinase C" + ] + }, + { + "id": "7452", + "type": "gene", + "text": "B cell antigen receptor ( BCR ) - induced apoptosis in the WEHI - 231 B lymphoma cell line can be prevented by engaging CD40 .", + "entities": [ + "B cell antigen receptor", + "BCR", + "CD40" + ] + }, + { + "id": "7453", + "type": "gene", + "text": "Five of these have ocular or oculocutaneous albinism .", + "entities": [] + }, + { + "id": "7454", + "type": "gene", + "text": "This structure interconnects specific triplets of the basal bodies with the microtubular bundles that emerge from the basal apparatus .", + "entities": [] + }, + { + "id": "7455", + "type": "gene", + "text": "A sharp outbreak of influenza A occurred on the base during February that was due to an A / Texas / 1 / 77 - like virus , a variant of the A / Victoria / 3 / 75 prototpye .", + "entities": [] + }, + { + "id": "7456", + "type": "gene", + "text": "Here we present evidence that major IE proteins IE86 , IE72 , and IE55 are capable of trans - activating the HIV LTR in a T - cell line , HUT - 78 .", + "entities": [ + "IE86", + "IE72", + "IE55", + "HIV LTR" + ] + }, + { + "id": "7457", + "type": "gene", + "text": "Closure of an open high below - knee guillotine amputation wound using a skin - stretching device .", + "entities": [] + }, + { + "id": "7458", + "type": "gene", + "text": "Application of the 2 - deoxy - D - glucose method to the coupling of cerebral metabolism and blood flow .", + "entities": [] + }, + { + "id": "7459", + "type": "gene", + "text": "Morphological features of Jat dentition .", + "entities": [] + }, + { + "id": "7460", + "type": "gene", + "text": "In addition , the overall chance that a patient would undergo ET was greater in a cycle in which more than one follicle 20 mm or larger was developing than in a cycle in which a single large follicle was developing .", + "entities": [] + }, + { + "id": "7461", + "type": "gene", + "text": "This correlated with reduced levels of secreted hepatitis B e antigen and increased intracellular levels of core and Pol proteins and replicative HBV DNA intermediates .", + "entities": [ + "hepatitis B e antigen", + "core", + "Pol proteins" + ] + }, + { + "id": "7462", + "type": "gene", + "text": "These striations were caused by contact between the sharp edge of the upper canine and the P3 during honing ( canine / premolar complex ) .", + "entities": [] + }, + { + "id": "7463", + "type": "gene", + "text": "Molecular characterization of type - specific capsular polysaccharide biosynthesis genes of Streptococcus agalactiae type Ia .", + "entities": [] + }, + { + "id": "7464", + "type": "gene", + "text": "With 0 . 5 vol . - % , the corresponding values were 345 mumol / 1 ( 5 . 72 mg / 100 ml ) and 137 mumol / 1 ( 2 . 25 mg / 100 ml ) respectively .", + "entities": [] + }, + { + "id": "7465", + "type": "gene", + "text": "T cell leukemia - associated human Notch / translocation - associated Notch homologue has I kappa B - like activity and physically interacts with nuclear factor - kappa B proteins in T cells .", + "entities": [ + "Notch", + "Notch", + "I kappa B", + "nuclear factor - kappa B" + ] + }, + { + "id": "7466", + "type": "gene", + "text": "CONCLUSIONS : The special clinical presentation of our case of possible Gardner ' s syndrome is discussed .", + "entities": [] + }, + { + "id": "7467", + "type": "gene", + "text": "Ischemia and reperfusion markedly increased the release of 6 - keto - PGF1 alpha and TXB2 .", + "entities": [] + }, + { + "id": "7468", + "type": "gene", + "text": "Estimated daily intakes ( EDIs ) per person were 0 . 56 microgram for total HCH , 0 . 20 microgram for gamma - HCH , 0 . 09 microgram for dieldrin , 1 . 42 micrograms for total DDT , and 0 . 15 microgram for HCB .", + "entities": [] + }, + { + "id": "7469", + "type": "gene", + "text": "The cryptococcal antigen test was positive at 1 : 125 by latex agglutination .", + "entities": [ + "cryptococcal antigen" + ] + }, + { + "id": "7470", + "type": "gene", + "text": "Six tandem repeats of the P element linked to the SV40 promoter responded to phorbol 12 - myristate 13 - acetate , while that of other elements did not .", + "entities": [ + "P element", + "SV40 promoter" + ] + }, + { + "id": "7471", + "type": "gene", + "text": "A significant degree of homology was also found among these genes and the Mtase gene of related phage SPR , which codes for an enzyme with different modification specificity .", + "entities": [ + "Mtase gene" + ] + }, + { + "id": "7472", + "type": "gene", + "text": "NMR of diffusing atoms in a periodic porous medium in the presence of a nonuniform magnetic field .", + "entities": [] + }, + { + "id": "7473", + "type": "gene", + "text": "Expression , cellular localization and in vitro transcription studies establish that cloned hUBF encodes a nucleolar factor that binds specifically to the upstream control element and core of the rRNA gene promoter to activate transcription in a binding site - dependent manner .", + "entities": [ + "cloned hUBF" + ] + }, + { + "id": "7474", + "type": "gene", + "text": "Additionally , putative CF1 / USP and Broad Complex Z2 transcription factor elements were found in the upstream regions of MIH and MO - IH genes respectively .", + "entities": [ + "CF1", + "USP", + "Broad Complex Z2", + "MIH", + "MO - IH" + ] + }, + { + "id": "7475", + "type": "gene", + "text": "The envelope glycoproteins of Rous sarcoma virus ( RSV ) , gp85 and gp37 , are anchored in the membrane by a 27 - amino acid , hydrophobic domain that lies adjacent to a 22 - amino acid , cytoplasmic domain at the carboxy terminus of gp37 .", + "entities": [ + "envelope glycoproteins of Rous sarcoma virus ( RSV )", + "gp85", + "gp37", + "gp37" + ] + }, + { + "id": "7476", + "type": "gene", + "text": "The encoded protein has a leader sequence of 27 amino acids .", + "entities": [] + }, + { + "id": "7477", + "type": "gene", + "text": "Radiation decreased the levels of T4 and T3 6 h and 72 h in group C , in group A at 72 h , in group B at 24 h postexposure .", + "entities": [] + }, + { + "id": "7478", + "type": "gene", + "text": "Here we show that PKC and p44 / p42MAPK signalings are required for the HBx - induced Sp1 - mediated IGF - II P4 transcriptional activity since ( i ) PKC activation by PMA or PKC expression vector increases Sp1 phosphorylation and P4 activity in HBx - transfected HepG2 cells ; ( ii ) PKC inhibition by PKC inhibitor Go6976 reduces Sp1 phosphorylation , P4 activity , and IGF - II mRNA in HBx - transfected HepG2 cells ; and ( iii ) the inhibition of MEK activation by U0126 reduces Sp1 phosphorylation , P4 activity and IGF - II mRNA in HBx - transfected HepG2 cells .", + "entities": [ + "PKC", + "p44", + "p42MAPK", + "HBx", + "Sp1", + "IGF - II P4", + "PKC", + "PKC", + "Sp1", + "P4", + "HBx", + "PKC", + "PKC", + "Sp1", + "P4", + "IGF - II mRNA", + "HBx", + "MEK", + "Sp1", + "P4", + "IGF - II mRNA", + "HBx" + ] + }, + { + "id": "7479", + "type": "gene", + "text": "Addition of soluble recombinant human SLF to SI4 - h220 cultures enhanced reduction of cell - surface c - kit expression and its protein degradation .", + "entities": [ + "recombinant human SLF", + "c - kit" + ] + }, + { + "id": "7480", + "type": "gene", + "text": "This study confirms , although individual reaction is remarkably different , transportation as a potent stressor for Beagle dogs .", + "entities": [] + }, + { + "id": "7481", + "type": "gene", + "text": "Among the v - myc codons , the first 5 are derived from the noncoding 5 ' terminus of the second c - myc exon , and 412 codons correspond to the c - myc coding region .", + "entities": [ + "v - myc", + "c - myc", + "c - myc" + ] + }, + { + "id": "7482", + "type": "gene", + "text": "The Aie1 locus was mapped to mouse chromosome 7A2 - A3 by fluorescent in situ hybridization .", + "entities": [ + "Aie1 locus" + ] + }, + { + "id": "7483", + "type": "gene", + "text": "The pigment intensity of both melanized colonies and appressoria of CAL transformants was weaker than that of the wild type .", + "entities": [] + }, + { + "id": "7484", + "type": "gene", + "text": "Expression was cell cycle controlled , with steady - state RNA levels significantly higher in growth - arrested than in growth - stimulated cells .", + "entities": [] + }, + { + "id": "7485", + "type": "gene", + "text": "Although the gene is substantially smaller than the human genes for other mitochondrial enzymes , its intron / exon organization is very similar , especially to that of P450scc .", + "entities": [ + "P450scc" + ] + }, + { + "id": "7486", + "type": "gene", + "text": "Disruption of RB / E2F - 1 interaction by single point mutations in E2F - 1 enhances S - phase entry and apoptosis .", + "entities": [ + "RB", + "E2F - 1", + "E2F - 1" + ] + }, + { + "id": "7487", + "type": "gene", + "text": "Dual roles of p82 , the clam CPEB homolog , in cytoplasmic polyadenylation and translational masking .", + "entities": [ + "p82", + "CPEB homolog" + ] + }, + { + "id": "7488", + "type": "gene", + "text": "Distribution and correlations of serum uric - acid in two French adult populations : 13 , 885 men and 6 , 861 women", + "entities": [] + }, + { + "id": "7489", + "type": "gene", + "text": "Patterns of connections underlying cross - modality integration were studied by injecting distinguishable , retrograde tracers ( Fluoro - Gold and diamidino yellow ) in pairwise manner into different sensory representations ( visual , somatosensory , and auditory ) in the cerebral cortex of the rat .", + "entities": [] + }, + { + "id": "7490", + "type": "gene", + "text": "Bacterially expressed protein , as well as the in vitro reticulocyte lysate translation product , comigrated with the purified 37 - kDa protein on sodium dodecyl sulfate - polyacrylamide gels .", + "entities": [] + }, + { + "id": "7491", + "type": "gene", + "text": "Induction of both potential transcripts follows heat shock in vivo .", + "entities": [] + }, + { + "id": "7492", + "type": "gene", + "text": "On the transport of mucus and its rheologic simulants in ciliated systems .", + "entities": [] + }, + { + "id": "7493", + "type": "gene", + "text": "Survey on antibody against egg drop syndrome - 1976 virus among chicken flocks in Japan .", + "entities": [] + }, + { + "id": "7494", + "type": "gene", + "text": "This is the first determination of the complete secondary structure of an RNA spliced in a spliceosome .", + "entities": [] + }, + { + "id": "7495", + "type": "gene", + "text": "Furthermore , both rhHR23 proteins function in a defined NER system reconstituted with purified proteins , indicating direct involvement of hHR23 proteins in the DNA repair reaction via interaction with XPC .", + "entities": [ + "rhHR23 proteins", + "hHR23 proteins", + "XPC" + ] + }, + { + "id": "7496", + "type": "gene", + "text": "Influence of compression therapy on symptoms following soft tissue injury from maximal eccentric exercise .", + "entities": [] + }, + { + "id": "7497", + "type": "gene", + "text": "The predicted amino acid sequence is 78 . 0 % identical to the cytoplasmic dynein heavy chain of Neurospora crassa , 70 . 2 % identical to that of Aspergillus nidulans and 24 . 8 % identical to that of Saccharomyces cerevisiae .", + "entities": [ + "cytoplasmic dynein heavy chain of Neurospora crassa" + ] + }, + { + "id": "7498", + "type": "gene", + "text": "The SH2 - containing adapter protein GRB10 interacts with BCR - ABL .", + "entities": [ + "GRB10", + "BCR", + "ABL" + ] + }, + { + "id": "7499", + "type": "gene", + "text": "Identification and nucleotide sequence of Rhizobium meliloti insertion sequence ISRm3 : similarity between the putative transposase encoded by ISRm3 and those encoded by Staphylococcus aureus IS256 and Thiobacillus ferrooxidans IST2 .", + "entities": [ + "Rhizobium meliloti insertion sequence ISRm3", + "transposase", + "ISRm3", + "Staphylococcus aureus IS256", + "Thiobacillus ferrooxidans IST2" + ] + }, + { + "id": "7500", + "type": "gene", + "text": "The requirement for proteolytic activity of both FVIIa and FXa suggests that protease - activated receptors may be involved .", + "entities": [ + "FVIIa", + "FXa" + ] + }, + { + "id": "7501", + "type": "gene", + "text": "Cowpox virus contains two copies of an early gene encoding a soluble secreted form of the type II TNF receptor .", + "entities": [ + "early gene", + "type II TNF receptor" + ] + }, + { + "id": "7502", + "type": "gene", + "text": "Multivariate Cox survival analysis identified baseline EF < or = 30 % , presence of significant mitral regurgitation ( > 2 + ) before ablation , and failure to exhibit improved cardiac performance by 1 month after ablation as the only independent predictors of death .", + "entities": [] + }, + { + "id": "7503", + "type": "gene", + "text": "The 4 patients with carboxyhemoglobin levels in excess of 10 % may represent occult carbon monoxide poisoning in this population .", + "entities": [ + "carboxyhemoglobin" + ] + }, + { + "id": "7504", + "type": "gene", + "text": "Possibilities of needleless administration of various substances to animals", + "entities": [] + }, + { + "id": "7505", + "type": "gene", + "text": "Inductively coupled plasma atomic emission spectroscopy was employed to obtain the tissue silicon measurements .", + "entities": [] + }, + { + "id": "7506", + "type": "gene", + "text": "Previous studies have indicated that a hamster cell line ( ts13 ) with a point mutation in the TAF ( II ) 250 / CCG1 ( TAF ( II ) 250 ) gene shows temperature - sensitive expression of a subset of genes and arrests in late G1 at 39 . 5 degrees C .", + "entities": [ + "TAF ( II ) 250", + "CCG1", + "TAF ( II ) 250" + ] + }, + { + "id": "7507", + "type": "gene", + "text": "Determination of lead in blood .", + "entities": [] + }, + { + "id": "7508", + "type": "gene", + "text": "DNA sequence analysis reveals that the gene encodes a protein highly homologous to rat CRP1 .", + "entities": [ + "rat CRP1" + ] + }, + { + "id": "7509", + "type": "gene", + "text": "Radiosensitive nature of paravascular infiltrate - producing potential of parental spleen cells .", + "entities": [] + }, + { + "id": "7510", + "type": "gene", + "text": "The weak base ketoconazole showed complete dissolution from a tablet formulation in Simulated Gastric Fluid without pepsin ( SGFsp ) within 30 minutes , 70 % dissolution in 2 hours under fed state simulated upper jejunal conditions but only 6 % dissolution in 2 hours under fasted state conditions .", + "entities": [ + "pepsin" + ] + }, + { + "id": "7511", + "type": "gene", + "text": "Within 12 hours after MR tomography the patients were surgically explored , biopsied and if necessary orchiectomised .", + "entities": [] + }, + { + "id": "7512", + "type": "gene", + "text": "Using an RNase H - mediated mapping technique , we show that the 64 - kDa subunit of CstF can be photo cross - linked to pre - mRNAs at U - rich regions located downstream of the cleavage site of the simian virus 40 late and adenovirus L3 pre - mRNAs .", + "entities": [ + "RNase H", + "CstF", + "adenovirus L3 pre - mRNAs" + ] + }, + { + "id": "7513", + "type": "gene", + "text": "Dopamine caused a prominent potassium efflux measured as 86Rb + efflux from control glands , but was without effect in denervated glands .", + "entities": [] + }, + { + "id": "7514", + "type": "gene", + "text": "Two specific DNA - protein complexes were identified in gel retardation assays using HeLa cell nuclear extracts and an oligonucleotide probe spanning the footprinted region .", + "entities": [] + }, + { + "id": "7515", + "type": "gene", + "text": "The R . meliloti nifH promoter but not the K . pneumoniae nifH promoter showed sigma 54 - dependent methylation protection of guanine residues at - 14 , - 25 and - 26 , the most conserved nucleotides characteristic of sigma 54 - dependent promoters .", + "entities": [ + "R . meliloti nifH promoter", + "K . pneumoniae nifH promoter", + "sigma 54", + "sigma 54 - dependent promoters" + ] + }, + { + "id": "7516", + "type": "gene", + "text": "A previous report described that a 548 - bp BglII - SmaI fragment has an SSO activity ( ori2 ; Kataoka et al . , Mol .", + "entities": [ + "BglII", + "SmaI" + ] + }, + { + "id": "7517", + "type": "gene", + "text": "None of the five proprotein processing proteases tested were capable of cleaving human pro - LPH , strongly suggesting that they are not involved in the maturation of this enzyme .", + "entities": [ + "human pro - LPH" + ] + }, + { + "id": "7518", + "type": "gene", + "text": "This combined intravenous anaesthetic regimen gave good anaesthesia and analgesia to pigs for up to 2 h as monitored by clinical signs .", + "entities": [] + }, + { + "id": "7519", + "type": "gene", + "text": "For wild type MutT and its E53D and E44D mutants , plots of log ( k ( cat ) ) versus pH exhibited a limiting slope of 1 on the ascending limb and then a hump , i . e . , a sharply defined maximum near pH 8 followed by a plateau , yielding apparent pK ( a ) values of 7 . 6 + / - 0 . 3 and 8 . 4 + / - 0 . 4 for an essential base and a nonessential acid catalyst , respectively , in the active quaternary MutT - Mg ( 2 + ) - dGTP - Mg ( 2 + ) complex .", + "entities": [ + "MutT", + "E53D", + "E44D mutants", + "MutT" + ] + }, + { + "id": "7520", + "type": "gene", + "text": "It is concluded that the unique suppository formulation of CZX - S is useful in the treatment of infections in children with heavy psychophysiologic disorders and in children who cannot take oral drugs because of severe vomiting .", + "entities": [] + }, + { + "id": "7521", + "type": "gene", + "text": "In calves receiving milk - substitute diets containing 80 - 260 g DM / kg , milk intakes were reduced by up to 30 % on the 1st day that calves were fed once daily instead of twice daily .", + "entities": [] + }, + { + "id": "7522", + "type": "gene", + "text": "Thus , BALB / c mice appear to be the most appropriate strain of mice to perform studies on the possible connection between infection with T . canis and allergic asthma .", + "entities": [] + }, + { + "id": "7523", + "type": "gene", + "text": "Two alternatively spliced 5 ' UTRs , designated type I and type II , of 222 and 115 bp , respectively , were found associated with PFP .", + "entities": [ + "PFP" + ] + }, + { + "id": "7524", + "type": "gene", + "text": "Cotransfection with the ie1 gene resulted in a dramatic increase in the amount of the two enzymes expressed in the transfected cells .", + "entities": [ + "ie1 gene" + ] + }, + { + "id": "7525", + "type": "gene", + "text": "Moreover , by complementation of the WA fyuA mutant by the cloned fyuA gene , yersiniabactin uptake and mouse virulence were restored .", + "entities": [ + "WA fyuA mutant", + "fyuA gene" + ] + }, + { + "id": "7526", + "type": "gene", + "text": "However , Southern blot and karyotype analyses did not reveal any significant changes in copy number or gross rearrangements of the p53 gene in any of the p53 - cell lines .", + "entities": [ + "p53 gene", + "p53 -" + ] + }, + { + "id": "7527", + "type": "gene", + "text": "A murine expressed sequence tag ( EST ) showing homology with erythropoietin receptor ( EPOR ) was identified in the EST database .", + "entities": [ + "erythropoietin receptor", + "EPOR" + ] + }, + { + "id": "7528", + "type": "gene", + "text": "The distribution and organization of projections from the spinal cervical enlargement to subnucleus reticularis dorsalis ( SRD ) and the neighbouring Cuneate nucleus ( Cu ) area was studied in the rat by using microinjections of Phaseolus vulgaris leucoagglutinin ( PHA - L ) into different laminae around the C7 level .", + "entities": [ + "Phaseolus vulgaris leucoagglutinin", + "PHA - L" + ] + }, + { + "id": "7529", + "type": "gene", + "text": "Ritanserin is a new substance with highly selective blocking activity on S2 receptors for 5 - HT in the central nervous system .", + "entities": [ + "S2 receptors" + ] + }, + { + "id": "7530", + "type": "gene", + "text": "The generally adopted criteria enabling to classify the examined persons into the following 3 groups have been used : ( a ) diseased of BEN ; ( b ) suspect to be diseased of BEN , and ( c ) individuals without signs of a renal disease .", + "entities": [] + }, + { + "id": "7531", + "type": "gene", + "text": "Protease activities in cultures of the streptococcal strains were associated with species of different molecular masses ranging from 130 to 200 kDa , suggesting posttranslational processing possibly as a result of autoproteolysis at post - proline peptide bonds in the N - terminal parts of the molecules .", + "entities": [] + }, + { + "id": "7532", + "type": "gene", + "text": "Despite this DNA binding activity , AP - 1 reporter activity was suppressed in these cells .", + "entities": [ + "AP - 1 reporter" + ] + }, + { + "id": "7533", + "type": "gene", + "text": "The exon : intron structure of chicken IL8 corresponds almost exactly to that of human IL8 and differs from those of other known mammalian CXC chemokine genes .", + "entities": [ + "chicken IL8", + "human IL8", + "mammalian CXC chemokine genes" + ] + }, + { + "id": "7534", + "type": "gene", + "text": "In slightly older embryos , the expression was skewed to one side of the embryo and by E6 . 5 , at the onset of gastrulation , expression was seen in the epiblast , visceral endoderm , nascent mesoderm , and the primitive streak .", + "entities": [] + }, + { + "id": "7535", + "type": "gene", + "text": "The CBF1 site within HS2 resides near sites for hematopoietic regulators such as GATA - 1 , NF - E2 , and TAL1 .", + "entities": [ + "CBF1 site", + "GATA - 1", + "NF - E2", + "TAL1" + ] + }, + { + "id": "7536", + "type": "gene", + "text": "Reverse transcription - PCR analysis of mRNA from patients shows that each of these five mutations results in aberrant splicing .", + "entities": [] + }, + { + "id": "7537", + "type": "gene", + "text": "Conversely , E1A binding to only p300 / CBP results in an increase in PARP enzyme activity and consequently in cell death susceptibility to irradiation , which is effectively counteracted by the PARP chemical inhibitor 3 - aminobenzamide .", + "entities": [ + "E1A", + "p300", + "CBP", + "PARP enzyme", + "PARP" + ] + }, + { + "id": "7538", + "type": "gene", + "text": "The FFA levels were not affected ( P greater than . 1 ) by meal interval .", + "entities": [] + }, + { + "id": "7539", + "type": "gene", + "text": "In addition to the previously identified and characterized attenuator 1 situated 93 nucleotides downstream from the major late transcription start site , a second attenuator , attenuator 2 , situated 55 nucleotides downstream from it , has been identified .", + "entities": [ + "attenuator 1", + "attenuator 2" + ] + }, + { + "id": "7540", + "type": "gene", + "text": "Toward absolute methods in clinical chemistry : application of mass fragmentography to high - accuracy analyses .", + "entities": [] + }, + { + "id": "7541", + "type": "gene", + "text": "George T .", + "entities": [] + }, + { + "id": "7542", + "type": "gene", + "text": "We previously showed that the N - terminal portion common to various chimeric MLL products , as well as to MLL - LTG9 and MLL - LTG19 , localizes in the nuclei , and therefore suggested that it might play an important role in leukemogenesis .", + "entities": [ + "chimeric MLL products", + "MLL - LTG9", + "MLL - LTG19" + ] + }, + { + "id": "7543", + "type": "gene", + "text": "The IDF standard method for the detection of penicillin in milk is not suitable for the detection of sulphonamide residues in milk .", + "entities": [] + }, + { + "id": "7544", + "type": "gene", + "text": "However , D8 binding was observed by nuclease protection with lactotroph - as well as somatotroph - like cell nuclear protein .", + "entities": [ + "D8", + "lactotroph - as well as somatotroph - like cell nuclear protein" + ] + }, + { + "id": "7545", + "type": "gene", + "text": "Substitutions of region I with synthetic sequences showed that no specific sequence but rather repeats of three or more consecutive adenines or thymines , without interruption by guanine or cytosine , are required for the ARS activity .", + "entities": [] + }, + { + "id": "7546", + "type": "gene", + "text": "Several distinct apoptotic stimuli induce the expression and caspase - dependent cleavage of hTAF ( II ) 80 delta .", + "entities": [ + "caspase", + "hTAF ( II ) 80 delta" + ] + }, + { + "id": "7547", + "type": "gene", + "text": "hTAF ( II ) 80 delta , unlike hTAF ( II ) 80 , forms a TFIID - like complex lacking hTAF ( II ) 31 .", + "entities": [ + "hTAF ( II ) 80 delta", + "hTAF ( II ) 80", + "TFIID - like complex", + "hTAF ( II ) 31" + ] + }, + { + "id": "7548", + "type": "gene", + "text": "The American Burkitt Lymphoma Registry : a progress report .", + "entities": [] + }, + { + "id": "7549", + "type": "gene", + "text": "A third series of mice were given a single injection of 5 - OH - DA , sacrificed , and prepared for ultrastructural study .", + "entities": [] + }, + { + "id": "7550", + "type": "gene", + "text": "The selective 5 - HT3 receptor antagonists ramosetron ( YM060 ) , YM114 ( KAE - 393 ) , granisetron and ondansetron , and the substituted benzamides ( 5 - HT4 receptor agonist / 5 - HT3 receptor antagonists ) cisapride mosapride and SC - 53116 dose - dependently enhanced gastric emptying in normal rats .", + "entities": [ + "5 - HT3 receptor", + "5 - HT4 receptor", + "5 - HT3 receptor" + ] + }, + { + "id": "7551", + "type": "gene", + "text": "To determine whether food and / or water in the gastrointestinal tract affects restitution of blood volume and plasma protein after hemorrhage , fed and 24 - h - fasted awake rats received a 20 ml . kg - 1 x 3 min - 1 hemorrhage , and restitution of blood volume was measured by Evans blue dye and dilution of hematocrit .", + "entities": [] + }, + { + "id": "7552", + "type": "gene", + "text": "We compared previously the methylation status between normal liver and liver tumors in SV40 T / t antigen transgenic mice ( MT - D2 mice ) using Restriction Landmark Genomic Scanning for Methylation ( RLGS - M ) and identified several loci / spots that appeared to be methylated frequently in liver tumors .", + "entities": [ + "SV40 T / t antigen" + ] + }, + { + "id": "7553", + "type": "gene", + "text": "Biochemical analysis demonstrates that the BJ1 protein is associated with nucleosomes and is released from chromatin by agents which intercalate into DNA , as previously shown for the high mobility group proteins ( HMGs ) .", + "entities": [ + "BJ1 protein", + "high mobility group proteins", + "HMGs" + ] + }, + { + "id": "7554", + "type": "gene", + "text": "Cryoglobulinemia in Raynaud ' s syndrome", + "entities": [] + }, + { + "id": "7555", + "type": "gene", + "text": "U4 / U6 snRNP is one of four essential small nuclear ribonucleoprotein ( snRNP ) particles ( U1 , U2 , U5 and U4 / U6 ) present in the spliceosome .", + "entities": [ + "U4", + "U6", + "U1", + "U2", + "U5", + "U4", + "U6" + ] + }, + { + "id": "7556", + "type": "gene", + "text": "However , there is still a subset of tumors that displayed no changes in these genes .", + "entities": [] + }, + { + "id": "7557", + "type": "gene", + "text": "PrpB showed homology to carboxyphosphonoenolpyruvate phosphonomutase of Streptomyces hygroscopicus and to its homolog in the carnation Dianthus caryophyllus ; PrpC was homologous to both archaeal and bacterial citrate synthases ; PrpD showed homology to yeast and Bacillus subtilis proteins of unknown function ; PrpE showed homology to acetyl coenzyme A synthetases .", + "entities": [ + "PrpB", + "carboxyphosphonoenolpyruvate phosphonomutase of Streptomyces hygroscopicus", + "PrpC", + "archaeal and bacterial citrate synthases", + "PrpD", + "PrpE", + "acetyl coenzyme A synthetases" + ] + }, + { + "id": "7558", + "type": "gene", + "text": "This brief hypercapnic challenge induced a rapid increase in CBF in the absence of any change in MABP .", + "entities": [] + }, + { + "id": "7559", + "type": "gene", + "text": "We show that the en stripes expand anteriorly in slp mutant embryos and that slp activity is an absolute requirement for maintenance of wg expression at the same time that wg transcription is dependent on hh .", + "entities": [ + "en", + "slp", + "slp", + "wg", + "wg", + "hh" + ] + }, + { + "id": "7560", + "type": "gene", + "text": "In nine patients with renal failure routine haemodialysis was accompanied by a 30 per cent reduction in plasma ANP concentration .", + "entities": [ + "ANP" + ] + }, + { + "id": "7561", + "type": "gene", + "text": "The most common characteristics of VRE patients were recent prior vancomycin use , recent prior susceptible enterococcal infection , coinfection with other microbial pathogens , and concurrent fungal infection .", + "entities": [] + }, + { + "id": "7562", + "type": "gene", + "text": "METHODS : 9 cases of conventional intermittent tissue expansion ( CITE ) and 9 cases of continuous pressure - controlled tissue expansion ( CPTE ) were chosen for the study .", + "entities": [] + }, + { + "id": "7563", + "type": "gene", + "text": "Descriptions of this locus would allow comparison with functionally relevant molecular genetic features of other species ' homologous loci including the single - copy equid LH / CGbeta gene and the primate LHbeta - CGbeta gene cluster locus .", + "entities": [ + "LH", + "CGbeta", + "LHbeta", + "CGbeta" + ] + }, + { + "id": "7564", + "type": "gene", + "text": "Under resting conditions , activity levels of cardiac vagal and sympathetic outflows are not related across young , healthy human subjects and peripheral interaction is not manifest between the autonomic divisions .", + "entities": [] + }, + { + "id": "7565", + "type": "gene", + "text": "Assessment of the carcinogenicity of non - nutritive sweetners II : Cyclamates and cyclohexylamine .", + "entities": [] + }, + { + "id": "7566", + "type": "gene", + "text": "The genome of Thogoto virus comprises six segments of single - stranded , negative sense RNA .", + "entities": [] + }, + { + "id": "7567", + "type": "gene", + "text": "The range of serum concentrations , mean values , median values , and standard deviations for each analyte are reported for males and females and for three age groups ( 25 - 44 , 45 - 59 , 60 - 70 ) .", + "entities": [] + }, + { + "id": "7568", + "type": "gene", + "text": "The two genes code for polypeptides of 420 amino acids ( M . HgiCI ) and 345 amino acids ( R . HgiCI ) .", + "entities": [ + "polypeptides of 420 amino acids ( M . HgiCI )", + "345 amino acids ( R . HgiCI )" + ] + }, + { + "id": "7569", + "type": "gene", + "text": "In contrast , COUP - TF alone had no effect on repCRS2 - dependent reporter gene activity .", + "entities": [ + "COUP - TF" + ] + }, + { + "id": "7570", + "type": "gene", + "text": "Nip7p - depleted cells exhibited the same defects as Nop8p - depleted cells , except that they accumulated 27S precursors .", + "entities": [ + "Nip7p", + "Nop8p", + "27S precursors" + ] + }, + { + "id": "7571", + "type": "gene", + "text": "Partial sequencing of the region downstream of ORF - Pto revealed homology to the ru / AB genes , involved in UV resistance , from plasmid pPSR1 .", + "entities": [ + "ORF - Pto", + "ru / AB genes" + ] + }, + { + "id": "7572", + "type": "gene", + "text": "It is exclusively observed in smooth muscle cells by Northern blotting and immunohistochemical analysis and therefore designated \" smoothelin . \" A human smooth muscle cDNA library was screened with the monoclonal antibody R4A , and a full - size cDNA of the protein was selected .", + "entities": [ + "\" smoothelin . \"", + "monoclonal antibody R4A" + ] + }, + { + "id": "7573", + "type": "gene", + "text": "GETS - 1 is expressed in many tissues , but is enriched in retina and brain .", + "entities": [ + "GETS - 1" + ] + }, + { + "id": "7574", + "type": "gene", + "text": "Methylation at both cytosine residues in the E2F element ( ( m ) CG ( m ) CG ) generated a new methylcytosine - specific DNA - protein complex .", + "entities": [ + "E2F" + ] + }, + { + "id": "7575", + "type": "gene", + "text": "CONCLUSION : Presence of APOE epsilon4 / * seems to increase the risk for dementia and AD independently of its effect on dyslipidemia and atherogenesis .", + "entities": [ + "APOE epsilon4 / *" + ] + }, + { + "id": "7576", + "type": "gene", + "text": "How plants respond to attack by the range of herbivores and pathogens that confront them in the field is the subject of considerable research by both molecular biologists and ecologists .", + "entities": [] + }, + { + "id": "7577", + "type": "gene", + "text": "Mapping of the human Voltage - Dependent Anion Channel isoforms 1 and 2 reconsidered .", + "entities": [ + "human Voltage - Dependent Anion Channel isoforms 1 and 2" + ] + }, + { + "id": "7578", + "type": "gene", + "text": "The observed incidence rates were compared to expected rates in the general population .", + "entities": [] + }, + { + "id": "7579", + "type": "gene", + "text": "In transient assays , using rice suspension - cultured cells transformed by particle bombardment , we showed previously that Oshox1 can transcriptionally repress the activity of reporter gene constructs with upstream HD - Zip binding sites .", + "entities": [ + "Oshox1", + "HD - Zip" + ] + }, + { + "id": "7580", + "type": "gene", + "text": "The other inhibitor was a single TAR decoy , driven by the U6 small nuclear RNA promoter ( U6 - P ) .", + "entities": [ + "TAR", + "U6 small nuclear RNA promoter", + "U6 - P" + ] + }, + { + "id": "7581", + "type": "gene", + "text": "Therefore more active and tolerable salvage regimens are needed .", + "entities": [] + }, + { + "id": "7582", + "type": "gene", + "text": "Here , we report theoretical models for the Gla and EGF - 1 modules of human PS constructed using prothrombin and factor X experimental structures .", + "entities": [ + "EGF - 1 modules", + "human PS", + "prothrombin", + "factor X" + ] + }, + { + "id": "7583", + "type": "gene", + "text": "Furthermore , we demonstrate that transcription from the MMTV 5 ' LTR is highly active in the absence of Stat5a , a transcription factor that had been shown previously to be required for transcription from the MMTV LTR .", + "entities": [ + "MMTV 5 ' LTR", + "Stat5a", + "MMTV LTR" + ] + }, + { + "id": "7584", + "type": "gene", + "text": "There was a significant but similar elevation of mean O2 uptake during 40 min postexercise by 13 . 6 % in both the fasted ( p less than 0 . 001 ) and fed state ( p less than 0 . 001 ) .", + "entities": [] + }, + { + "id": "7585", + "type": "gene", + "text": "Prostate - specific antigen ( PSA ) promoter - driven androgen - inducible expression of sodium iodide symporter in prostate cancer cell lines .", + "entities": [ + "Prostate - specific antigen", + "PSA", + "sodium iodide symporter" + ] + }, + { + "id": "7586", + "type": "gene", + "text": "Pigs were switched from the growing to the finishing diet at 57 and 61 kg in Exp .", + "entities": [] + }, + { + "id": "7587", + "type": "gene", + "text": "Prostaglandins F ( PGF ) were measured in uterine vein , ovarian artery , and jugular vein plasma and in the endometrial tissues at various times during the bovine estrous cycle , and were compared to peripheral plasma progesterone levels .", + "entities": [] + }, + { + "id": "7588", + "type": "gene", + "text": "They also occur in similar locations in the promoters of several other ribosomal protein genes .", + "entities": [ + "ribosomal protein genes" + ] + }, + { + "id": "7589", + "type": "gene", + "text": "An automated method for the quantitative analysis of the polyamines putrescine , spermidine and spermine in cerebrospinal fluid ( CSF ) was used to analyze CSF samples from 37 patients with central nervous system ( CNS ) tumors and from 13 patients without tumors .", + "entities": [] + }, + { + "id": "7590", + "type": "gene", + "text": "Chimeras containing IE1 peptides dramatically activated transcription of the basal promoter only when lac operator sequences were present .", + "entities": [ + "IE1 peptides", + "lac operator sequences" + ] + }, + { + "id": "7591", + "type": "gene", + "text": "These findings indicate that the t ( 4 ; 14 ) ( p16 . 3 ; q32 ) represents a novel , recurrent chromosomal translocation in MM , and suggest that the FGFR3 gene may be the target of this abnormality and thus contribute to tumorigenesis in MM .", + "entities": [ + "FGFR3 gene" + ] + }, + { + "id": "7592", + "type": "gene", + "text": "What ' s new in gynecologic and obstetrical surgery .", + "entities": [] + }, + { + "id": "7593", + "type": "gene", + "text": "This study demonstrates secretion of bicarbonate by the human stomach in vivo at a rate equivalent to 10 - - 20 % of basal acid secretion .", + "entities": [] + }, + { + "id": "7594", + "type": "gene", + "text": "Long - term results with MACOP - B and radiation therapy for aggressive lymphomas ] BACKGROUND : Long - term results are needed to evaluate chemotherapy regimens and prognostic factors in non - Hodgkin ' s lymphomas ( NHL ) .", + "entities": [] + }, + { + "id": "7595", + "type": "gene", + "text": "Mutagenesis of the CDE / CHR elements and Sp1 sites in this region , alone or in combination , reduced transcriptional activity by 40 - 60 % in asynchronously growing cells and abolished cell cycle periodicity in G2 - M - synchronized cells .", + "entities": [ + "Sp1 sites" + ] + }, + { + "id": "7596", + "type": "gene", + "text": "The transcriptional activities of the full - length promoter ( - 295 to + 85 ) and of three deletion constructs ( - 197 , - 154 and - 74 to + 85 ) were significantly down - regulated in resistant cells .", + "entities": [] + }, + { + "id": "7597", + "type": "gene", + "text": "Our data indicate that SIP1 is required to confine XBra gene expression to the mesoderm .", + "entities": [ + "SIP1", + "XBra gene" + ] + }, + { + "id": "7598", + "type": "gene", + "text": "After determining isoflurane MAC in triplicate , birds were given a mu - opioid agonist ( morphine , n = 9 ) or a kappa - opioid agonist ( U50488H , n = 9 ) .", + "entities": [] + }, + { + "id": "7599", + "type": "gene", + "text": "Respiratory chain enzyme activity was normal .", + "entities": [] + }, + { + "id": "7600", + "type": "gene", + "text": "Reporting of adverse events occurring during clinical trials of investigational drugs is a complex and controversial issue .", + "entities": [] + }, + { + "id": "7601", + "type": "gene", + "text": "Thus , SAG appears to control cell cycle progression in yeast by promoting ubiquitination and degradation of cell cycle regulatory proteins .", + "entities": [ + "SAG" + ] + }, + { + "id": "7602", + "type": "gene", + "text": "Vitiligo in diabetes mellitus .", + "entities": [] + }, + { + "id": "7603", + "type": "gene", + "text": "Previous studies indicated that the 20S proteasome is a catalytic core of the 26S proteolytic complex that possesses a latent multicatalytic proteinase activity and catalyzes an ATP - dependent , selective breakdown of proteins ligated to ubiquitin .", + "entities": [ + "20S proteasome", + "26S proteolytic complex", + "ubiquitin" + ] + }, + { + "id": "7604", + "type": "gene", + "text": "Subsequent cloning and nucleotide sequence analysis of the S . pombe adenylate kinase gene , adk1 , revealed a coding region of 660 nucleotides .", + "entities": [ + "S . pombe adenylate kinase gene", + "adk1" + ] + }, + { + "id": "7605", + "type": "gene", + "text": "For HeLa , 293 , U937 , and A549 cells , participation of E2F - 1 , DP - 1 , cyclin A , and RB was involved in formation of some complexes only , assuming participation of factors different from E2F - 1 or DP - 1 in others .", + "entities": [ + "E2F - 1", + "DP - 1", + "cyclin A", + "RB", + "E2F - 1", + "DP - 1" + ] + }, + { + "id": "7606", + "type": "gene", + "text": "The activity of serum lipase and amylase distinctly increased at 3 h and went up to the maximum at 12 h after injection of Na - Tc .", + "entities": [ + "serum lipase", + "amylase" + ] + }, + { + "id": "7607", + "type": "gene", + "text": "Because of the potential implications of these findings in human physiology , we cloned the hPACAP - R gene .", + "entities": [ + "hPACAP - R gene" + ] + }, + { + "id": "7608", + "type": "gene", + "text": "However , the elderly group showed significantly longer mean residence times ( MRTs ) and lower plasma clearance of lidocaine during the period compared with the adult group ( P < . 05 ) .", + "entities": [] + }, + { + "id": "7609", + "type": "gene", + "text": "Members of the mitogen activated protein ( MAP ) kinase family , extracellular signal - regulated kinase , stress - activated protein kinase - 1 / c - Jun NH2 - terminal kinase , and p38 , are central elements that transduce the signal generated by growth factors , cytokines , and stressing agents .", + "entities": [ + "mitogen activated protein ( MAP ) kinase family", + "extracellular signal - regulated kinase", + "stress - activated protein kinase - 1", + "c - Jun NH2 - terminal kinase", + "p38" + ] + }, + { + "id": "7610", + "type": "gene", + "text": "Diltiazem resulted in a significant increase in epicardial diameter ( + 10 % ; p = 0 . 001 ) and in coronary blood flow ( CBF ) ( + 30 % ; p = 0 . 0001 ) .", + "entities": [] + }, + { + "id": "7611", + "type": "gene", + "text": "Clinical and haematological signs are not specific in this setting , and the diagnosis relies on histological features , mainly bone marrow examination .", + "entities": [] + }, + { + "id": "7612", + "type": "gene", + "text": "Here we show that phosphorylation - induced loss of the protein kinase activity of DNA - PK is restored by the addition of the purified catalytic subunit of either protein phosphatase 1 or protein phosphatase 2A ( PP2A ) and that this reactivation is blocked by the potent protein phosphatase inhibitor , microcystin .", + "entities": [ + "DNA - PK", + "protein phosphatase 1", + "protein phosphatase 2A", + "PP2A" + ] + }, + { + "id": "7613", + "type": "gene", + "text": "Therefore the procedure of Lich - Gregoir is not to be recommended in adults .", + "entities": [] + }, + { + "id": "7614", + "type": "gene", + "text": "The remaining six patients had slightly decreased ( n = 3 ) or normal ( n = 3 ) seminal parameters .", + "entities": [] + }, + { + "id": "7615", + "type": "gene", + "text": "The Saccharomyces cerevisiae RAD30 gene , a homologue of Escherichia coli dinB and umuC , is DNA damage inducible and functions in a novel error - free postreplication repair mechanism .", + "entities": [ + "Saccharomyces cerevisiae RAD30 gene", + "homologue of Escherichia coli dinB", + "umuC" + ] + }, + { + "id": "7616", + "type": "gene", + "text": "Despite the activation of these intracellular signaling molecules , PDGF beta receptor activation elicited no detectable effect on cell proliferation or differentiation .", + "entities": [ + "PDGF beta receptor" + ] + }, + { + "id": "7617", + "type": "gene", + "text": "The mapping was completed with Southern blotting and restriction analysis .", + "entities": [] + }, + { + "id": "7618", + "type": "gene", + "text": "And the natural barriers ?", + "entities": [] + }, + { + "id": "7619", + "type": "gene", + "text": "Dual radionuclide subtraction imaging of the spleen using 67Ga citrate and 99mTc is useful in further delineating lesions that are identified on either a routine radiogallium survey or on a conventional sulfur colloid liver - spleen image .", + "entities": [] + }, + { + "id": "7620", + "type": "gene", + "text": "Genesis of foam cells : study in rats after administration of Cloforex .", + "entities": [] + }, + { + "id": "7621", + "type": "gene", + "text": "Sip1 was initially identified by virtue of its interaction with SC35 , a splicing factor of the SR family .", + "entities": [ + "Sip1", + "SC35", + "SR family" + ] + }, + { + "id": "7622", + "type": "gene", + "text": "Histopathologically , a cystic lymphangioma was diagnosed because of the morphological features and the immunohistochemical stainings of CD34 and Factor VIII related antigen which were observed positive reactions in endothelial cells of the cysts .", + "entities": [ + "CD34", + "Factor VIII related antigen" + ] + }, + { + "id": "7623", + "type": "gene", + "text": "Toxicity was mild , mainly consisting of emesis ( 81 % of the patients ; 66 % of the courses ) , leukopenia of World Health Organization ( WHO ) grade 1 to 2 ( 47 % of the patients ; 18 % of the courses ) , and thrombocytopenia ( 12 % of the patients ; 3 % of the courses ) .", + "entities": [] + }, + { + "id": "7624", + "type": "gene", + "text": "This function requires not only the kinase domain of Csk , but also its Src homology 3 ( SH3 ) and SH2 regions .", + "entities": [ + "Csk", + "Src homology 3", + "SH3", + "SH2" + ] + }, + { + "id": "7625", + "type": "gene", + "text": "Complete recovery of liver function after this surgery tended to be slow .", + "entities": [] + }, + { + "id": "7626", + "type": "gene", + "text": "These synergistic effects were strongly Jem - 1 dose - dependent .", + "entities": [ + "Jem - 1" + ] + }, + { + "id": "7627", + "type": "gene", + "text": "The initial phase of increased vascular permeability in the peritoneal cavity and LTB4 production was dose dependently inhibited by the 5 - LO inhibitors phenidone , BW A4C , A63162 , and ICI 207 968 but not by dexamethasone or colchicine .", + "entities": [] + }, + { + "id": "7628", + "type": "gene", + "text": "CsA alone resulted in elevated bone turnover .", + "entities": [] + }, + { + "id": "7629", + "type": "gene", + "text": "The sample includes all the HIV - infected - patients continuously referred to the Outpatient Service of the Infectious Diseases dept . of Bologna ' s \" Ospedale Maggiore \" General Hospital during some five days ( 19 - 23rd , July 1993 ) .", + "entities": [] + }, + { + "id": "7630", + "type": "gene", + "text": "Benztropine for venlafaxine - induced night sweats .", + "entities": [] + }, + { + "id": "7631", + "type": "gene", + "text": "Sequential MR examinations of the nasal cavity and paranasal sinuses were performed within a 6 - 8 h period in five normal volunteers .", + "entities": [] + }, + { + "id": "7632", + "type": "gene", + "text": "Analysis in 3 groups of patients suffering from simple acute and pernicious malarial flare - ups", + "entities": [] + }, + { + "id": "7633", + "type": "gene", + "text": "Moreover , unlike control rats operated animals did not show aversion to the highest concentrations of saccharin solutions .", + "entities": [] + }, + { + "id": "7634", + "type": "gene", + "text": "In this paper , we have analyzed the structure of human gene for Gx alpha , which spans more than 60 kilobases .", + "entities": [ + "Gx alpha" + ] + }, + { + "id": "7635", + "type": "gene", + "text": "ICP4 has been shown to form tripartite complexes cooperatively with the TATA box - binding protein and TFIIB on DNA containing an ICP4 binding site and a TATA box ( C .", + "entities": [ + "ICP4", + "TATA box - binding protein", + "TFIIB", + "ICP4 binding site" + ] + }, + { + "id": "7636", + "type": "gene", + "text": "This differential sensitivity to DB , as measured by a lower concentration of DB which caused loss of righting in LS , was accompanied by an equal rate of water - soluble barbiturate brain distribution and elimination in the two lines .", + "entities": [] + }, + { + "id": "7637", + "type": "gene", + "text": "NF - HB ( BSAP ) is a repressor of the murine immunoglobulin heavy - chain 3 ' alpha enhancer at early stages of B - cell differentiation .", + "entities": [ + "NF - HB", + "BSAP", + "murine immunoglobulin heavy - chain 3 ' alpha enhancer" + ] + }, + { + "id": "7638", + "type": "gene", + "text": "The NIT2 protein is localised in nuclei and could not be detected in the cytoplasmic fraction of cells subjected to nitrogen derepression or nitrogen repression , indicating that the nuclear import of NIT2 is not regulated .", + "entities": [ + "NIT2 protein", + "NIT2" + ] + }, + { + "id": "7639", + "type": "gene", + "text": "After 7 days , a spontaneous regression of the morphologic alterations caused by caerulein - induced acute pancreatitis occurs ; however , recovery of the secretory function of the pancreas was only reached after this period of time when L - 364 , 718 was administered therapeutically ( 0 . 1 mg / kg / day ) .", + "entities": [] + }, + { + "id": "7640", + "type": "gene", + "text": "Using a previously published two - frequency ( AC excitation ) three - electrode method , the admittance locus plot ( ALP ) in the low - frequency region ( < 1000 Hz ) has been shown to be very well approximated by a straight line and can be described with frequency - independent parameters ; phase angle alpha pi / 2 , conductance at extrapolated zero frequency G0 = 1 / R0 , and ion relaxation time tau .", + "entities": [] + }, + { + "id": "7641", + "type": "gene", + "text": "This motif has been shown to mediate protein interactions in the case of ankyrin as well as several other repeat - bearing proteins .", + "entities": [ + "ankyrin" + ] + }, + { + "id": "7642", + "type": "gene", + "text": "To examine transcriptional regulation of the rat eIF4E gene , 2 . 1 kB of the rat eIF4E promoter region was cloned and the contribution of specific elements in regulating transcription was determined in primary cultures of rat cardiocytes and in a murine C ( 2 ) C ( 12 ) myoblast cell line .", + "entities": [ + "rat eIF4E gene", + "rat eIF4E promoter region" + ] + }, + { + "id": "7643", + "type": "gene", + "text": "Therefore , Mxi1 and Mad might antagonize Myc function and are candidate tumor suppressor genes .", + "entities": [ + "Mxi1", + "Mad", + "Myc" + ] + }, + { + "id": "7644", + "type": "gene", + "text": "The clinical application of the antibody - targeted Phthalocyanine was performed in 3 patients suffering from an advanced ovarian carcinoma ( FIGO III ) .", + "entities": [] + }, + { + "id": "7645", + "type": "gene", + "text": "Recent target BP goals promulgated by the Sixth Report from the Joint National Committee ( JNC VI ) are based on the premise that the intensity of treatment directly corresponds to the magnitude of pretreatment risk .", + "entities": [] + }, + { + "id": "7646", + "type": "gene", + "text": "We describe a novel zinc finger protein , dsRBP - ZFa , isolated by screening an expression library with dsRNA .", + "entities": [ + "zinc finger protein", + "dsRBP - ZFa" + ] + }, + { + "id": "7647", + "type": "gene", + "text": "NPT II synthesis , measured by agar plate assays of kanamycin resistance and by immunoprecipitation of the NPT II protein , was repressed in the presence of cysteine and derepressed in its absence .", + "entities": [ + "NPT II", + "NPT II protein" + ] + }, + { + "id": "7648", + "type": "gene", + "text": "Young fish ( Oreochromis mossambicus ) were exposed to microgravity ( micro g ) for 9 to 10 days during space missions STS - 55 and STS - 84 , or to hypergravity ( hg ) for 9 days .", + "entities": [] + }, + { + "id": "7649", + "type": "gene", + "text": "Neither RD19 nor RD21 mRNA synthesis was responsive to cold or to heat stress .", + "entities": [ + "RD19", + "RD21 mRNA" + ] + }, + { + "id": "7650", + "type": "gene", + "text": "Studies on immunoglobulin E : the impact of a sojourn with Professor Dan H .", + "entities": [ + "immunoglobulin E" + ] + }, + { + "id": "7651", + "type": "gene", + "text": "More mRNA corresponding to nagB and nagA is detected than that corresponding to the distal genes , nagC and nagD .", + "entities": [ + "nagB", + "nagA", + "nagC", + "nagD" + ] + }, + { + "id": "7652", + "type": "gene", + "text": "Correlation of skin disorders with CD4 lymphocyte counts in patients with HIV / AIDS .", + "entities": [ + "CD4" + ] + }, + { + "id": "7653", + "type": "gene", + "text": "Identification of a new gene in the streptococcal plasmid pLS1 : the rnaI gene .", + "entities": [ + "rnaI gene" + ] + }, + { + "id": "7654", + "type": "gene", + "text": "So far 15 children have been studied .", + "entities": [] + }, + { + "id": "7655", + "type": "gene", + "text": "Waves N1 , P3 and CNV were recorded during a CNV paradigm in a simple reaction time task with a constant interstimulus interval ( ISI ) of 1 sec .", + "entities": [] + }, + { + "id": "7656", + "type": "gene", + "text": "Preface .", + "entities": [] + }, + { + "id": "7657", + "type": "gene", + "text": "In the former cells , ets - 2 was a CSF - 1 immediate - early response gene , and phosphorylated ets - 2 was detected after 2 to 4 h , coincident with expression of ets - 2 protein .", + "entities": [ + "ets - 2", + "CSF - 1", + "ets - 2", + "ets - 2 protein" + ] + }, + { + "id": "7658", + "type": "gene", + "text": "These results would suggest that a high UV sensitivity is associated with high phaeomelanin and low eumelanin levels , and point to the eumelanin / phaeomelanin ratio as a novel chemical parameter that could be used for predicting individuals at high risk for skin cancer and melanoma .", + "entities": [] + }, + { + "id": "7659", + "type": "gene", + "text": "Rhizobium meliloti large plasmid pRmeGR4b carries the nodulation competitiveness locus nfe responsible for the nodulation efficiency and competitive ability of strain GR4 on alfalfa roots .", + "entities": [ + "nfe" + ] + }, + { + "id": "7660", + "type": "gene", + "text": "A computerized method of determining the focal point of electrical activity in the pallidum of parkinsonian patients was developed using on - line quantitative physiological data analysis .", + "entities": [] + }, + { + "id": "7661", + "type": "gene", + "text": "The radiation burden associated with the majority of examinations in nuclear medicine expressed as the effective dose is comparable with the radiation burden of radiodiagnostic examinations , only after administration of preparations with 131I , 201Tl , 67Ga and 111In it is markedly higher .", + "entities": [] + }, + { + "id": "7662", + "type": "gene", + "text": "These cells produce a low level of IL - 5 when stimulated with PMA alone ; however , N6 , O2 - dibutyryl cAMP ( Bt2cAMP ) , in combination with PMA , augmented by more than tenfold the IL - 5 production at the mRNA and the protein levels .", + "entities": [ + "IL - 5", + "IL - 5" + ] + }, + { + "id": "7663", + "type": "gene", + "text": "Specialist in family practice - - prototype of a doctor .", + "entities": [] + }, + { + "id": "7664", + "type": "gene", + "text": "In addition , a 21 - mer subrepeat structure is also present in each unit .", + "entities": [] + }, + { + "id": "7665", + "type": "gene", + "text": "It is concluded that fludarabine is a highly useful agent in CLL .", + "entities": [] + }, + { + "id": "7666", + "type": "gene", + "text": "Interferon - alpha - induced gene expression : evidence for a selective effect of ouabain on activation of the ISGF3 transcription complex .", + "entities": [ + "Interferon - alpha", + "ISGF3 transcription complex" + ] + }, + { + "id": "7667", + "type": "gene", + "text": "The DNA sequence immediately upstream from the - 10 hexamer contained the TGn motif described as an extended - 10 region in prokaryotic promoters .", + "entities": [] + }, + { + "id": "7668", + "type": "gene", + "text": "The transcription factor CHOP ( C / EBP homologous protein 10 ) is a bZIP protein induced by a variety of stimuli that evoke cellular stress responses and has been shown to arrest cell growth and to promote programmed cell death .", + "entities": [ + "transcription factor CHOP", + "C / EBP homologous protein 10", + "bZIP protein" + ] + }, + { + "id": "7669", + "type": "gene", + "text": "Open reading frames in a 4556 nucleotide sequence within MDV - 1 BamHI - D DNA fragment : evidence for splicing of mRNA from a new viral glycoprotein gene .", + "entities": [ + "MDV - 1 BamHI - D DNA fragment" + ] + }, + { + "id": "7670", + "type": "gene", + "text": "The systolic peak of pulmonary vein was higher than the diastolic peak in 45 out of 56 cases .", + "entities": [] + }, + { + "id": "7671", + "type": "gene", + "text": "To identify critical regions mediating growth signal transduction by hG - CSFR , deletions or site - directed amino acid substitutions were introduced into the cytoplasmic domain of hG - CSFR , and the mutant cDNAs were transfected into the murine interleukin - 3 ( IL - 3 ) - dependent Ba / F3 and FDCP cell lines .", + "entities": [ + "hG - CSFR", + "hG - CSFR", + "murine interleukin - 3", + "IL - 3" + ] + }, + { + "id": "7672", + "type": "gene", + "text": "Structural organization of the gene encoding the human lipocalin tear prealbumin and synthesis of the recombinant protein in Escherichia coli .", + "entities": [ + "human lipocalin tear prealbumin" + ] + }, + { + "id": "7673", + "type": "gene", + "text": "CONCLUSIONS .", + "entities": [] + }, + { + "id": "7674", + "type": "gene", + "text": "Since the latter is very small for physiological flows , the result is that alpha < 1 even at relatively high values of the Reynolds number ( i . e . , for non - negligible inertia ) and we validate our perturbation theory results by comparison with a numerical integration of the full model .", + "entities": [] + }, + { + "id": "7675", + "type": "gene", + "text": "Twenty - two of the 24 patients had a rise in the total serum amylase following ERCP .", + "entities": [ + "amylase" + ] + }, + { + "id": "7676", + "type": "gene", + "text": "X - ray crystallographic data show that the PLZF BTB / POZ domain forms an obligate homodimer via an extensive interface .", + "entities": [ + "BTB" + ] + }, + { + "id": "7677", + "type": "gene", + "text": "Letter : Aryl hydrocarbon hydroxylase and smoking .", + "entities": [ + "Aryl hydrocarbon hydroxylase" + ] + }, + { + "id": "7678", + "type": "gene", + "text": "( 1992 ) Genomics 12 , 58 - 62 ) .", + "entities": [] + }, + { + "id": "7679", + "type": "gene", + "text": "Rad6 mutants display a remarkably pleiotropic phenotype , implicating the protein in DNA damage - induced mutagenesis , postreplication repair , repression of retrotransposition , and sporulation .", + "entities": [ + "Rad6 mutants" + ] + }, + { + "id": "7680", + "type": "gene", + "text": "DNA sequencing and Southern blot analyses established that the cDNA clones are derived from two different genes .", + "entities": [] + }, + { + "id": "7681", + "type": "gene", + "text": "Postprandial plasma enteroglucagon concentration after 90 minutes in untreated patients correlated positively to the faecal fat excretion ( r = 0 . 58 , p less than 0 . 02 ) .", + "entities": [ + "plasma enteroglucagon" + ] + }, + { + "id": "7682", + "type": "gene", + "text": "The 5 ' - nontranslated sequences and parts of the coding sequences of various yeast genes have been cloned into representative lacZ fusion vectors .", + "entities": [ + "lacZ" + ] + }, + { + "id": "7683", + "type": "gene", + "text": "Here we show that epidermal growth factor or platelet - derived growth factor stimulation of intact human or murine cells leads to phosphorylation of Nck protein on tyrosine , serine , and threonine residues .", + "entities": [ + "epidermal growth factor", + "platelet - derived growth factor", + "Nck protein" + ] + }, + { + "id": "7684", + "type": "gene", + "text": "It has been established that preoperative irradiation in the form of the fractionation of a single focal dose of 6 Gy every other day , the summary dose of 24 Gy within 8 - 10 days followed by surgery 1 - 3 days after irradiation does not either complicate its performance or the course of the postoperative period , and by the short - and long - term results it is no worse than the routine dose fractionation .", + "entities": [] + }, + { + "id": "7685", + "type": "gene", + "text": "This region , however , contains a CCAATC box in the reverse complement and several GC boxes that are recognition sites for SP1 .", + "entities": [ + "SP1" + ] + }, + { + "id": "7686", + "type": "gene", + "text": "One hundred twenty units of deglycerolized red blood cells , some with glycerol added so as to exceed an acceptable 1 % glycerol content , had measurements made of the post - wash supernatant fluid by refractive index and osmometry .", + "entities": [] + }, + { + "id": "7687", + "type": "gene", + "text": "Analysis of intragenic revertants shows that this function depends on the amino acid preceding the first cysteine residue of the DNA - binding domain of Hap1p .", + "entities": [ + "Hap1p" + ] + }, + { + "id": "7688", + "type": "gene", + "text": "This sequence possessed homology with a methylation - sensitive promoter element , Enh2 , present in the LTR of mouse intractisternal A - particles .", + "entities": [] + }, + { + "id": "7689", + "type": "gene", + "text": "Cis - acting CCAAT elements are frequently found in eukaryotic promoter regions .", + "entities": [] + }, + { + "id": "7690", + "type": "gene", + "text": "METHODS : Fifty - eight patients who underwent a curative hepatic resection for HCC and whose preoperative AFP levels were > 100 ng / ml , were selected for this study .", + "entities": [ + "AFP" + ] + }, + { + "id": "7691", + "type": "gene", + "text": "Tobramycin - loaded SLN administered i . v . showed a prolonged circulation time compared to the i . v . administered tobramycin solution .", + "entities": [] + }, + { + "id": "7692", + "type": "gene", + "text": "The future of research with interferon may be divided into three areas : Efforts must be made to determine how best to translate the in vitro synergy into clinically meaningful terms ; in order to exploit the fullest potential of IFN , research is moving toward using this agent earlier in disease either as an adjuvant after tumor debulking or after initial diagnosis ; the medical community must rethink the natural history of some diseases , because the fullest potential of the biologic agents will most likely manifest itself when these agents are used together .", + "entities": [ + "interferon", + "IFN" + ] + }, + { + "id": "7693", + "type": "gene", + "text": "We used a rev - and RRE - defective HIV type 1 ( HIV - 1 ) molecular clone in complementation experiments to establish a method for the rapid isolation of posttranscriptional regulatory elements from the mammalian genome by selecting for rescue of virus replication .", + "entities": [ + "rev", + "RRE" + ] + }, + { + "id": "7694", + "type": "gene", + "text": "This sequence similarity raises the possibility that GCN1 interacts with ribosomes or tRNA molecules and functions in conjunction with GCN2 in monitoring uncharged tRNA levels during the process of translation elongation .", + "entities": [ + "GCN1", + "GCN2" + ] + }, + { + "id": "7695", + "type": "gene", + "text": "The combination of ifosfamide , epirubicin and etoposide ( IEV ) is an effective salvage regimen for lymphoproliferative disease .", + "entities": [] + }, + { + "id": "7696", + "type": "gene", + "text": "RNase protection analyses indicate that either 61 - kDa CaM PDE mRNA or structurally related transcripts encoding different CaM PDE isoforms are expressed in a tissue - specific manner .", + "entities": [ + "RNase", + "61 - kDa CaM PDE mRNA", + "CaM PDE isoforms" + ] + }, + { + "id": "7697", + "type": "gene", + "text": "Plasma lipid and lipoprotein profiles were compared in elderly female runners ( RU : n = 15 , aged 66 + / - 5 years , body fat 20 + / - 4 % , training distance 35 + / - 15 km week - 1 , VO2max 36 + / - 4 ml kg - 1 min - 1 , mean + / - SD ) and age - matched untrained women ( UT : n = 28 , 66 + / - 4 years , body fat 26 + / - 6 % , VO2max 26 + / - 3 ml kg - 1 min - 1 ) .", + "entities": [] + }, + { + "id": "7698", + "type": "gene", + "text": "Since glutathione peroxidase ( GPX ) and superoxide dismutase ( SOD ) play a significant role in erythrocyte antioxidative defence , it is very important to determine their activity in occupationally exposed workers .", + "entities": [ + "glutathione peroxidase", + "GPX", + "superoxide dismutase", + "SOD" + ] + }, + { + "id": "7699", + "type": "gene", + "text": "The mMIWC1 promoter was identified and contained TATA , CAAT , GATA , and AP - 2 elements ; primer extension revealed mMIWC transcription initiation at 621 bp upstream from the mMIWC1 translational initiation site .", + "entities": [ + "mMIWC1 promoter", + "AP - 2 elements", + "mMIWC", + "mMIWC1" + ] + }, + { + "id": "7700", + "type": "gene", + "text": "We therefore applied a radiolabelled serumalbumin method to determine blood volume after haemodilution with crosslinked or conjugated haemoglobin , in comparison with a reference solution of hydroxyethyl starch ( HES ) .", + "entities": [ + "serumalbumin", + "haemoglobin" + ] + }, + { + "id": "7701", + "type": "gene", + "text": "Moreover , expression of CBF1 in yeast was found to activate transcription of reporter genes containing the C - repeat / DRE as an upstream activator sequence but not mutant versions of the DNA element .", + "entities": [ + "CBF1" + ] + }, + { + "id": "7702", + "type": "gene", + "text": "At some sites , % T is greatly increased by Cl - concentrations up to 1 M , while at other sites % T is reduced or unaffected by these conditions .", + "entities": [] + }, + { + "id": "7703", + "type": "gene", + "text": "Retroviral nucleocapsid proteins ( NCPs ) are CCHC - type zinc finger proteins that mediate virion RNA binding activities associated with retrovirus assembly and genomic RNA encapsidation .", + "entities": [ + "Retroviral nucleocapsid proteins", + "NCPs", + "CCHC - type zinc finger proteins" + ] + }, + { + "id": "7704", + "type": "gene", + "text": "They correspond to nucleotides equivalent to base - pair C1 - G72 and discriminator base A73 in the amino acid - acceptor branch of the molecule .", + "entities": [] + }, + { + "id": "7705", + "type": "gene", + "text": "The protein expressed from the cloned cDNA is secreted into the culture medium and yields of up to 40 mg per litre have been obtained .", + "entities": [] + }, + { + "id": "7706", + "type": "gene", + "text": "Small Maf proteins interact with the human transcription factor TCF11 / Nrf1 / LCR - F1 .", + "entities": [ + "Maf proteins", + "TCF11", + "Nrf1", + "LCR - F1" + ] + }, + { + "id": "7707", + "type": "gene", + "text": "Antithrombin III deficiency : when substitute , when heparin ?", + "entities": [ + "Antithrombin III" + ] + }, + { + "id": "7708", + "type": "gene", + "text": "Thrombosis ABC , 3 : The role of antithrombin III", + "entities": [] + }, + { + "id": "7709", + "type": "gene", + "text": "Although no statistical significance was achieved , it is remarkable that there was a clear trend for the superiority of Galphimia D6 while the Galphimia dilution 10 ( - 6 ) was about equally effective compared with placebo .", + "entities": [] + }, + { + "id": "7710", + "type": "gene", + "text": "We report here the identification of a cDNA that encodes a new member of the GTPase - activating protein ( GAP ) family of GTPase regulators .", + "entities": [ + "GTPase - activating protein", + "GAP", + "GTPase" + ] + }, + { + "id": "7711", + "type": "gene", + "text": "The partial ORF was found to be identical to the C terminus of HrpJ2 .", + "entities": [ + "HrpJ2" + ] + }, + { + "id": "7712", + "type": "gene", + "text": "The partial ORF was found to be identical to the C terminus of HrpJ2 .", + "entities": [ + "HrpJ2" + ] + }, + { + "id": "7713", + "type": "gene", + "text": "The treatment of hydronephrosis in children", + "entities": [] + }, + { + "id": "7714", + "type": "gene", + "text": "By adapting a method for DNA - footprinting using impure extracts of ner overproducing cells , we were able to determine that the ner - binding sites are located between nucleotides 1026 and 1058 from the Mu left end .", + "entities": [ + "ner", + "ner - binding sites" + ] + }, + { + "id": "7715", + "type": "gene", + "text": "The effects of glutaraldehyde on dimensions and ultrastructure of microvascular beds in rat mesentery were studied in two kinds of experiment , administering the fixative by intra - arterial perfusion at a pressure of 80 mm Hg and by superfusion of the exteriorized mesenteric membrane .", + "entities": [] + }, + { + "id": "7716", + "type": "gene", + "text": "A surgical technique for correcting this problem is described .", + "entities": [] + }, + { + "id": "7717", + "type": "gene", + "text": "Drosophila 230 - kD TFIID subunit , a functional homolog of the human cell cycle gene product , negatively regulates DNA binding of the TATA box - binding subunit of TFIID .", + "entities": [ + "TFIID", + "TATA box - binding subunit of TFIID" + ] + }, + { + "id": "7718", + "type": "gene", + "text": "In HeLa cells , the JNKK2 - JNK1 fusion protein showed significant JNK activity , which was comparable with that of JNK1 activated by many stimuli and activators , including EGF , TNF - alpha , anisomycin , UV irradiation , MEKK1 , and small GTP binding proteins Rac1 and Cdc42Hs .", + "entities": [ + "JNKK2", + "JNK1", + "JNK", + "JNK1", + "EGF", + "TNF - alpha", + "MEKK1", + "small GTP binding proteins Rac1", + "Cdc42Hs" + ] + }, + { + "id": "7719", + "type": "gene", + "text": "Incorporation of the polyene antibiotic amphotericin B ( AMB ) in liposomes results in a marked reduction in drug toxicity with no loss of antifungal potency .", + "entities": [] + }, + { + "id": "7720", + "type": "gene", + "text": "Pathways linking the olfactory bulbs with the medial preoptic anterior hypothalamus are important for intermale aggression in mice .", + "entities": [] + }, + { + "id": "7721", + "type": "gene", + "text": "There were 18 patients with Group II ( a ) tumors ; although tumor biopsy was attempted on eight of these , pathological diagnosis at the time of surgery was made in only one case .", + "entities": [] + }, + { + "id": "7722", + "type": "gene", + "text": "The high conservation of the 3 ' terminus suggests that this region directs the assembly of proteins required for the initiation of RNA replication .", + "entities": [] + }, + { + "id": "7723", + "type": "gene", + "text": "Vector stocks containing envelope proteins from three different SIVmac clones , namely , SIVmac239 ( T - lymphocyte tropic [ T - tropic ] ) , SIVmac316 ( macrophage tropic [ M - tropic ] ) , and SIVmac1A11 ( dualtropic ) , were tested .", + "entities": [ + "envelope proteins" + ] + }, + { + "id": "7724", + "type": "gene", + "text": "The weight - bearing surface of the PE head became smoother with time after THA , and the friction coefficient did not differ significantly from that of an unused PE head .", + "entities": [] + }, + { + "id": "7725", + "type": "gene", + "text": "The goal of the present study was to determine the feasibility of retrovirus mediated expression of rp47phox in the HL60 and U937 human hematopoietic cell lines , and in an Epstein - Barr virus transformed B - lymphocyte cell line ( EBV - BCL ) derived from a p47phox - deficient CGD patient .", + "entities": [ + "rp47phox", + "p47phox" + ] + }, + { + "id": "7726", + "type": "gene", + "text": "With respect to the distribution of active MREs over the promoter region , the hMT - IIA gene is largely different from the mouse metallothionein - I gene , suggesting that MRE arrangement is not an important factor for metal regulation .", + "entities": [ + "hMT - IIA gene", + "metallothionein - I gene" + ] + }, + { + "id": "7727", + "type": "gene", + "text": "Re : A modified method for the in vivo labeling of red blood cells with Tc - 99m .", + "entities": [] + }, + { + "id": "7728", + "type": "gene", + "text": "Object relations , affect management , and psychic structure formation .", + "entities": [] + }, + { + "id": "7729", + "type": "gene", + "text": "Atheroma appears as a very low signal intensity area on 2 - dimensional time - of - flight ( TOF ) magnetic resonance ( MR ) images , and its components have various signal intensities on spin - echo ( SE ) images .", + "entities": [] + }, + { + "id": "7730", + "type": "gene", + "text": "The yeast silent information regulator Sir4p anchors and partitions plasmids .", + "entities": [ + "silent information regulator Sir4p" + ] + }, + { + "id": "7731", + "type": "gene", + "text": "The zona pellucida ( ZP ) , the extracellular glycocalyx that surrounds the oocyte , is well known to mediate homologous gamete interaction .", + "entities": [] + }, + { + "id": "7732", + "type": "gene", + "text": "However , C3 toxin alone or in combination with growth factors did not stimulate AP - 1 : Luc activity and actually antagonized the synergistic activation of AP - 1 : Luc observed in response to co - stimulation with growth factors and Ro - 31 - 8220 .", + "entities": [ + "C3 toxin", + "AP - 1", + "Luc", + "AP - 1", + "Luc" + ] + }, + { + "id": "7733", + "type": "gene", + "text": "This indicates that the mechanism by which CX blocks rapid degradation of tubulin mRNA in vivo is not simply by preventing its translation and suggests the involvement of an altered trans - factor .", + "entities": [ + "tubulin mRNA" + ] + }, + { + "id": "7734", + "type": "gene", + "text": "Metabolism of calcium and vitamin D3 in patients with acute tubulointerstitial nephritis : a study of 41 patients with nephropathia epidemica .", + "entities": [] + }, + { + "id": "7735", + "type": "gene", + "text": "Eliminating any subset of ASCUS reduces the ASCUS / SIL ratio but also significantly diminishes the sensitivity of the Papanicolaou test .", + "entities": [] + }, + { + "id": "7736", + "type": "gene", + "text": "The other patients continued the trial with single daily doses of monotherapy .", + "entities": [] + }, + { + "id": "7737", + "type": "gene", + "text": "Thirty - five strains of Legionnaires ' disease bacteria were shown to belong in four distinct serologic groups on the basis of findings obtained with direct fluorescent antibody testing .", + "entities": [] + }, + { + "id": "7738", + "type": "gene", + "text": "Mapping of RNA - temperature - sensitive mutants of Sindbis virus : complementation group F mutants have lesions in nsP4 .", + "entities": [ + "temperature - sensitive mutants of Sindbis virus : complementation group F mutants", + "nsP4" + ] + }, + { + "id": "7739", + "type": "gene", + "text": "Interestingly , this amino - terminal determinant appears not to reside in the HSV - alpha TIF , which displays no independent amino - terminal activity .", + "entities": [ + "alpha TIF" + ] + }, + { + "id": "7740", + "type": "gene", + "text": "A comparison of the nucleotide sequence of the p54 gene carried by two virulent ASFV strains ( E70 and E75 ) with that obtained from virus Ba71V showed 100 % similarity .", + "entities": [ + "p54 gene" + ] + }, + { + "id": "7741", + "type": "gene", + "text": "The fibrinogen , serum proteins , sodium heparin and membrane contributed to Cm by 20 % , 14 % , 2 % and 64 % , respectively .", + "entities": [ + "fibrinogen" + ] + }, + { + "id": "7742", + "type": "gene", + "text": "A MEK - specific inhibitor ( PD098059 ) ( Dudley , D .", + "entities": [ + "MEK" + ] + }, + { + "id": "7743", + "type": "gene", + "text": "These data indicate that the interaction of eIF4A with the middle region of eIF4GI is necessary for translation , whereas the interaction of eIF4A with the C - terminal region plays a modulatory role .", + "entities": [ + "eIF4A", + "eIF4GI", + "eIF4A" + ] + }, + { + "id": "7744", + "type": "gene", + "text": "Marked elevation of creatine kinase was observed while serum albumin , immunoglobulin , and complement were decreased .", + "entities": [ + "creatine kinase", + "albumin", + "immunoglobulin" + ] + }, + { + "id": "7745", + "type": "gene", + "text": "Plasma secretin levels also augmented after the administration of ethanol solutions , with a delay of about one hour after the onset of acid secretion .", + "entities": [ + "Plasma secretin" + ] + }, + { + "id": "7746", + "type": "gene", + "text": "Characterization of these R subunits by their 8 - azido - cAMP photoaffinity labeling and immunoreactivity , as well as by a phosphorylation - dependent mobility shift on sodium dodecyl sulfate - polyacrylamide gel electrophoresis ( SDS - PAGE ) , indicated subunit sizes of RII beta ( 53 kDa ) greater than RII alpha dephosphoform ( 51 kDa ) greater than RI alpha ( 49 kDa ) .", + "entities": [ + "RII beta", + "RII alpha", + "RI alpha" + ] + }, + { + "id": "7747", + "type": "gene", + "text": "Platelet activating factor was given in six doses at 15 minute intervals and airway response measured as change in partial expiratory flow at 30 % of vital capacity ( Vp30 ) .", + "entities": [ + "Platelet activating factor" + ] + }, + { + "id": "7748", + "type": "gene", + "text": "The CNXA domain is similar at the amino acid level to the Escherichia coli moaA gene product , while CNXC is similar to the E . coli moaC product , with both E . coli products encoded by different cistrons .", + "entities": [ + "Escherichia coli moaA gene product", + "E . coli moaC product" + ] + }, + { + "id": "7749", + "type": "gene", + "text": "However , a cosmid clone containing the entire mouse alpha 1 ( I ) gene , including 3 . 7 kb of 5 ' - and 4 kb of 3 ' - flanking DNA , was expressed at reduced levels in fibroblasts overexpressing oncogenic ras .", + "entities": [ + "mouse alpha 1 ( I ) gene", + "oncogenic ras" + ] + }, + { + "id": "7750", + "type": "gene", + "text": "The tramtrack ( ttk ) gene of Drosophila encodes 69 - kDa and 88 - kDa proteins through alternative splicing of the primary ttk transcript .", + "entities": [ + "tramtrack", + "ttk", + "ttk transcript" + ] + }, + { + "id": "7751", + "type": "gene", + "text": "The optimum technique for the pathological examination of sentinel lymph nodes ( SLNs ) is still under debate .", + "entities": [] + }, + { + "id": "7752", + "type": "gene", + "text": "RESULTS : Auditory thresholds collected during audiometric tests increased gradually in proportion with age , especially in the hypertensive group ( p < 0 . 05 ) .", + "entities": [] + }, + { + "id": "7753", + "type": "gene", + "text": "Investigation on the exchange of Ca45 in intact and burned rats by the kinetic analysis method", + "entities": [] + }, + { + "id": "7754", + "type": "gene", + "text": "Osteocalcin ( and urinary hydroxyproline ) were not elevated in isolated hyperphosphatasaemia , indicating that mechanisms other than increased bone turnover may account for the markedly elevated serum alkaline phosphatase activity in these subjects .", + "entities": [ + "Osteocalcin", + "serum alkaline phosphatase" + ] + }, + { + "id": "7755", + "type": "gene", + "text": "Space limitations prevent an exhaustive review of all biologic pharmaceuticals , such as tissue plasminogen activating substance , hormones ( e . g . , thyroid , insulin , growth hormone , erythropoietin ) , clotting factors , and blood products .", + "entities": [ + "tissue plasminogen activating substance", + "insulin", + "growth hormone", + "erythropoietin" + ] + }, + { + "id": "7756", + "type": "gene", + "text": "Critique of \" Interactive Effects of Test Anxiety and Credit / No Credit or A - F Grade Condition upon Short - term and Long - term Recall of Course Information .", + "entities": [] + }, + { + "id": "7757", + "type": "gene", + "text": "Acquired bile duct blockage : entry of hepatobiliary agent into an intrahepatic abscess .", + "entities": [] + }, + { + "id": "7758", + "type": "gene", + "text": "Reduced NK activity correlates with active disease in HIV - patients with multidrug - resistant pulmonary tuberculosis .", + "entities": [] + }, + { + "id": "7759", + "type": "gene", + "text": "A cytosolic variant of the protein underwent efficient transphosphorylation , yet failed to activate appreciably either p70 ( S6k ) or MAP kinase following treatment with FK1012 .", + "entities": [ + "p70", + "S6k", + "MAP kinase" + ] + }, + { + "id": "7760", + "type": "gene", + "text": "Using the polymerase chain reaction , Whipple - specific DNA fragments of 284 base pairs from the genome of the Whipple bacterium ( Tropheryma whippelii ) were demonstrated .", + "entities": [] + }, + { + "id": "7761", + "type": "gene", + "text": "Haemodynamic responses to antagonism of bocurarine block with atropine - neostigmine mixture in children .", + "entities": [] + }, + { + "id": "7762", + "type": "gene", + "text": "His carnitine palmitoyltransferase ( CPT ) I and II activities were 0 . 06 and 0 . 12 nmol / min / mg protein , as compared with a mean value of 0 . 22 + / - 0 . 14 and 0 . 27 + / - 0 . 07 nmol / min / mg protein , respectively , in control subjects .", + "entities": [ + "carnitine palmitoyltransferase ( CPT ) I and II" + ] + }, + { + "id": "7763", + "type": "gene", + "text": "This study represents the first published long - term follow - up regarding this mode of treatment in patients with alveolar hypoventilation .", + "entities": [] + }, + { + "id": "7764", + "type": "gene", + "text": "The relationships between the partial pressures of O2 and CO2 as well as between their gradients , become stronger with the increase of the ventilation - perfusion ratio .", + "entities": [] + }, + { + "id": "7765", + "type": "gene", + "text": "We have recently shown that the tissue - specific expression of the RAR beta 2 gene in mouse embryos is regulated at the translational level by short upstream open reading frames ( uORFs ) In the 5 ' - untranslated region ( Zimmer , A . , A . M .", + "entities": [ + "RAR beta 2 gene in mouse embryos" + ] + }, + { + "id": "7766", + "type": "gene", + "text": "The presence of type I hypersensitivity in a subgroup of aspergillomas suggests an immunoallergic component to this disease which could contribute to a chronic inflammatory response to Aspergillus in some aspergillomas .", + "entities": [] + }, + { + "id": "7767", + "type": "gene", + "text": "Angiography of aneurysmal bone cyst .", + "entities": [] + }, + { + "id": "7768", + "type": "gene", + "text": "Although Grice ' s operation has been used all over the world , no systematic account of it has been found in the literature ( including publications dealing with technique ) , which presents it in terms related to the basic \" classical \" principles on which the operation was conceived .", + "entities": [] + }, + { + "id": "7769", + "type": "gene", + "text": "Chernoff , submitted for publication ) .", + "entities": [] + }, + { + "id": "7770", + "type": "gene", + "text": "Testing for serum IgM binding to GM1 ganglioside in clinical practice .", + "entities": [ + "serum IgM" + ] + }, + { + "id": "7771", + "type": "gene", + "text": "Breast cancer risk assessment : Who holds the magic crystal ball ?", + "entities": [] + }, + { + "id": "7772", + "type": "gene", + "text": "This study demonstrated that the PFA - 100 analyzer can accurately assess vWF - dependent platelet function and detect other platelet defects under high shear stress in complex patient populations .", + "entities": [ + "vWF" + ] + }, + { + "id": "7773", + "type": "gene", + "text": "However , after PRK at 5 weeks of age , partial retreatment may be necessary due to regression of the PRK effect .", + "entities": [] + }, + { + "id": "7774", + "type": "gene", + "text": "Invertases are responsible for the breakdown of sucrose to fructose and glucose .", + "entities": [ + "Invertases" + ] + }, + { + "id": "7775", + "type": "gene", + "text": "Clinical evaluation of the Allergan Humphrey 500 autorefractor and the Nidek AR - 1000 autorefractor .", + "entities": [] + }, + { + "id": "7776", + "type": "gene", + "text": "Rhesus macaques and BALB / c mice inoculated with the Mengo virus SIV recombinants failed to develop CTL responses against the SIV gene products , while one of the HIV - Nef recombinants induced a weak CTL response in mice directed to an HIV1 Nef peptide spanning positions 182 - 198 .", + "entities": [ + "HIV - Nef recombinants", + "HIV1 Nef peptide" + ] + }, + { + "id": "7777", + "type": "gene", + "text": "In contrast , mutations affecting the other two Nim1p - related kinases in S . cerevisiae , Hsl1p and Kcc4p , produce no detectable effect on septin organization .", + "entities": [ + "Nim1p - related kinases", + "Hsl1p", + "Kcc4p", + "septin" + ] + }, + { + "id": "7778", + "type": "gene", + "text": "Triton - disrupted cells retained capacity for activation of the pathway by both peptide growth factors and by addition of GTP - loaded p21 rasVal12 .", + "entities": [ + "rasVal12" + ] + }, + { + "id": "7779", + "type": "gene", + "text": "A miracle cure and its solution", + "entities": [] + }, + { + "id": "7780", + "type": "gene", + "text": "In a prospective randomized study , 287 patients with advanced non - small cell lung cancer ( NSCLC ) stage IIIb or IV with ECOG performance status ( PS ) 0 - 1 or 2 were randomly assigned to receive either best supportive care ( BSC ) or supportive care plus combination chemotherapy ( IEP regimen : ifosfamide 3 gm / m2 IV with mesna uroprotection , epirubicin 60 mg / m2 IV on day 1 and cisplatin 60 mg / m2 IV on day 2 ; or MVP regimen : mitomycin - C 8 mg / m2 , cisplatin 100 mg / m2 IV on day 1 , vinblastine 4 mg / m2 IV on days 1 and 15 ) .", + "entities": [] + }, + { + "id": "7781", + "type": "gene", + "text": "Online teaching : design and techniques .", + "entities": [] + }, + { + "id": "7782", + "type": "gene", + "text": "In myometrial SMC , both isoforms of the progesterone receptor , PR - B and PR - A , caused a ligand - dependent activation of PGDH - 2368 / luc3 .", + "entities": [ + "progesterone receptor", + "PR - B", + "PR - A", + "PGDH - 2368", + "luc3" + ] + }, + { + "id": "7783", + "type": "gene", + "text": "Carcinoembryonic antigen ( CEA ) procedures and clinical evaluation .", + "entities": [ + "Carcinoembryonic antigen", + "CEA" + ] + }, + { + "id": "7784", + "type": "gene", + "text": "Comparative studies of the antithrombin III level and plasminogen activator activity in patients with thrombophlebitis", + "entities": [ + "antithrombin III", + "plasminogen activator" + ] + }, + { + "id": "7785", + "type": "gene", + "text": "Human rIL - 3 expressed in COS7 cells has multipotential CSF activity in semisolid cultures of bone marrow cells , and selectively induced the proliferation of My - 10 + marrow or cord blood cells in liquid cultures .", + "entities": [ + "Human rIL - 3", + "CSF" + ] + }, + { + "id": "7786", + "type": "gene", + "text": "The plasmid shuffle technique was used to replace the wild - type gene with the mutant form , resulting in failure of the yeast cells to grow .", + "entities": [] + }, + { + "id": "7787", + "type": "gene", + "text": "Increased urinary riboflavin excretion resulting from boric acid ingestion .", + "entities": [] + }, + { + "id": "7788", + "type": "gene", + "text": "The VirR response regulator from Clostridium perfringens binds independently to two imperfect direct repeats located upstream of the pfoA promoter .", + "entities": [ + "VirR response regulator", + "pfoA promoter" + ] + }, + { + "id": "7789", + "type": "gene", + "text": "Grade 3 - 4 mucositis was present in 13 % of the cycles .", + "entities": [] + }, + { + "id": "7790", + "type": "gene", + "text": "Similarly , expression of a transiently transfected wild - type prothymosin alpha gene as the reporter was not affected by a repertoire of myc - derived genes , including myc itself and dominant or recessive negative myc mutants .", + "entities": [ + "wild - type prothymosin alpha gene", + "myc - derived genes", + "myc", + "myc mutants" + ] + }, + { + "id": "7791", + "type": "gene", + "text": "Transabdominal repair of type IV thoraco - abdominal aortic aneurysms .", + "entities": [] + }, + { + "id": "7792", + "type": "gene", + "text": "Although L - threo - dihydroxyphenylserine ( DOPS ) , an artificial norepinephrine ( NE ) precursor , did not change immobility in intact mice , DOPS significantly reduced immobility in mice pretreated with the selective NE neurotoxin DSP4 .", + "entities": [] + }, + { + "id": "7793", + "type": "gene", + "text": "It consists of 2185 amino acid residues encoded by a 9 - kilobase pair mRNA ; several splice variants have been detected in human and rat cDNA libraries .", + "entities": [] + }, + { + "id": "7794", + "type": "gene", + "text": "This animal model of dystonia appears to be a model of NAD in man from the viewpoint of treatment - response .", + "entities": [] + }, + { + "id": "7795", + "type": "gene", + "text": "Fibrin gels and their possible implication for surface hemorheology in health and disease .", + "entities": [ + "Fibrin" + ] + }, + { + "id": "7796", + "type": "gene", + "text": "A mutant form of Vps1p lacking the entire GTP - binding domain interfered with vacuolar protein sorting in wild - type cells .", + "entities": [ + "Vps1p" + ] + }, + { + "id": "7797", + "type": "gene", + "text": "In budding yeast , this latter checkpoint response involves the proteins Mad1 , 2 , 3 , Bub1 and Bub3 , whose vertebrate counterparts localize to unattached kinetochores .", + "entities": [ + "Mad1 , 2 , 3", + "Bub1", + "Bub3" + ] + }, + { + "id": "7798", + "type": "gene", + "text": "Sequence comparisons of prokaryotic RCR initiators has revealed a set of three common motifs , two of which , a putative metal coordination site and a downstream active - site tyrosine motif , could be tentatively identified in parvoviral replicator proteins .", + "entities": [ + "prokaryotic RCR initiators", + "parvoviral replicator proteins" + ] + }, + { + "id": "7799", + "type": "gene", + "text": "This investigation was undertaken to determine whether consuming several small feedings of preexercise carbohydrate ( CHO ) , rather than a single bolus , would affect blood glucose and insulin responses during rest and exercise .", + "entities": [ + "insulin" + ] + }, + { + "id": "7800", + "type": "gene", + "text": "Using the two - hybrid system , we show that nonprenylated Rac1 interacts very weakly with Rho - GDI , pointing to the predominant role of protein - isoprene interaction in complex formation .", + "entities": [ + "Rac1", + "Rho - GDI" + ] + }, + { + "id": "7801", + "type": "gene", + "text": "Thus , SOX8 is a good candidate gene contributing to the mental retardation phenotype seen in ATR - 16 patients .", + "entities": [ + "SOX8" + ] + }, + { + "id": "7802", + "type": "gene", + "text": "Among eight graminaceous species tested , Ids3 expression was observed only in Fe - deficient roots of H . vulgare and Secale cereale . which not only secrete 2 ' - deoxymugineic acid ( DMA ) , but also mugineic acid ( MA ) and 3 - epihydroxymugineic acid ( epiHMA , H . vulgare ) , and 3 - hydroxymugineic acid ( HMA , S . cereale ) .", + "entities": [ + "Ids3" + ] + }, + { + "id": "7803", + "type": "gene", + "text": "To elucidate whether potential endocrine changes resulted from acute hypoxaemia alone , the underlying disease , or unspecific influences connected with the ICU setting , all measurements were compared to those of a completely healthy reference group ( REF ) with comparable acute experimental hypoxaemia .", + "entities": [] + }, + { + "id": "7804", + "type": "gene", + "text": "Coexpression of mouse PKR ( 1 - 515 ) WT as a Gal4 DNA - binding domain fusion with either the catalytic - deficient human PKR ( 1 - 551 ) K296R mutant , the RNA - binding - deficient human PKR ( 1 - 551 ) K64E / K296R double mutant , or wild - type mouse PKR ( 1 - 515 ) WT as full - length PKR - Gal4 activation domain fusions resulted in activation of the HIS3 and lacZ reporters .", + "entities": [ + "PKR ( 1 - 515 ) WT", + "Gal4", + "PKR ( 1 - 551 )", + "PKR ( 1 - 551 ) K64E / K296R", + "PKR ( 1 - 515 ) WT", + "PKR", + "Gal4", + "HIS3", + "lacZ" + ] + }, + { + "id": "7805", + "type": "gene", + "text": "Fraction 2 contains 1 , 25 ( OH ) 2 - vitamin D3 , vitamin D3 , 25 ( OH ) - vitamin D3 and 1 , 24 , 25 ( OH ) 3 - vitamin D3 .", + "entities": [] + }, + { + "id": "7806", + "type": "gene", + "text": "While TGF - beta1 does not alter the mitogen - induced expression and abundance of G1 phase cyclin D1 and cdks 4 and 2 in MCs , it inhibits cyclin E - cdk 2 activity , thus preventing mitogen - elicited phosphorylation and inactivation of pRb in G1 phase and transition to S phase .", + "entities": [ + "TGF - beta1", + "cyclin D1", + "cdks 4 and 2", + "cyclin E", + "cdk 2", + "pRb" + ] + }, + { + "id": "7807", + "type": "gene", + "text": "A human SPT3 - TAFII31 - GCN5 - L acetylase complex distinct from transcription factor IID .", + "entities": [ + "SPT3", + "TAFII31", + "GCN5", + "L acetylase", + "transcription factor IID" + ] + }, + { + "id": "7808", + "type": "gene", + "text": "Rep - Rep protein interaction was confirmed in vitro through coimmunoprecipitation experiments with a bacterially expressed maltose - binding protein - Rep78 fusion protein in combination with [ 35S ] methionine - labeled Rep78 synthesized in a coupled in vitro transcription - translation system .", + "entities": [ + "Rep", + "Rep", + "maltose - binding protein", + "Rep78", + "Rep78" + ] + }, + { + "id": "7809", + "type": "gene", + "text": "We argue that this is the general property of QSAR models developed using LOO cross - validation .", + "entities": [] + }, + { + "id": "7810", + "type": "gene", + "text": "Steal is a pathophysiological process in which increased blood flow through a low - resistance vascular bed is sufficient to divert flow away from a region of the central nervous system .", + "entities": [] + }, + { + "id": "7811", + "type": "gene", + "text": "Together , our data suggest that the TR2 orphan receptor may be a master regulator in modulating the activation of two key HREs , RARE beta and CRBPIIp , involved in the retinoic acid signal transduction pathway .", + "entities": [ + "TR2 orphan receptor" + ] + }, + { + "id": "7812", + "type": "gene", + "text": "Amounts of glucose infused during the last 20 min of each 2 hour insulin infusion were ( at 1 and 10 m / kg / min respectively ) : before treatment ( K + = 2 . 7 mmol / l ) : 2 . 4 and 8 . 4 mg / kg / min ; after spironolactone ( K + = 3 . 9 mmol / l ) : 3 . 3 and 15 . 4 mg / kg / min ; after indomethacine ( K + = 3 . 7 mmol / l ) : 5 and 19 mg / kg / min after stopping drugs ( K + = 2 . 9 mmol / l ) : 2 . 5 and 5 . 3 mg / kg / min .", + "entities": [ + "insulin" + ] + }, + { + "id": "7813", + "type": "gene", + "text": "Frozen / thawed extensor digitorum longus muscle tendon units had significantly lower values for load to failure ( p < 0 . 01 ) , energy absorbed to failure ( p < 0 . 01 ) , and strain at failure ( p < 0 . 01 ) , and they tended to fail at a different anatomic location ( p < 0 . 01 ) ( broadly at the fascia - muscle interface as compared with horizontally at the musculotendinous junction ) than fresh units .", + "entities": [] + }, + { + "id": "7814", + "type": "gene", + "text": "Our results demonstrate the importance of phosphate and calcium in influencing the secretion of PTH and CT in uremia .", + "entities": [ + "PTH", + "CT" + ] + }, + { + "id": "7815", + "type": "gene", + "text": "We conclude that cAMP , acting through PKA , is an essential regulator of basal CFTR gene expression and may mediate an induction of CFTR in responsive cell types .", + "entities": [ + "PKA", + "CFTR gene", + "CFTR" + ] + }, + { + "id": "7816", + "type": "gene", + "text": "Erythrocyte delta - aminolevulinic acid dehydratase ( ALAD ) activity , erythrocyte zinc protoporphyrin ( ZPP ) / heme ratio , and urinary coproporphyrin ( UC ) concentration have been employed as biological indicators of moderate - to high - level lead exposure , corresponding to blood levels in excess of 50 micrograms / dl , in human subjects .", + "entities": [ + "Erythrocyte delta - aminolevulinic acid dehydratase", + "ALAD" + ] + }, + { + "id": "7817", + "type": "gene", + "text": "Disruption of any one of the four genes encoding the newly identified SRP proteins results in slow cell growth and inefficient protein translocation across the ER membrane .", + "entities": [ + "SRP proteins" + ] + }, + { + "id": "7818", + "type": "gene", + "text": "Stimulation with MCh produced a Ca - dependent transient elevation of cGMP level from 10 to 80 fmol / gland , peaking at 1 - 2 min but returning to the basal level by 5 min .", + "entities": [] + }, + { + "id": "7819", + "type": "gene", + "text": "Catecholamines and aversive learning : a review .", + "entities": [] + }, + { + "id": "7820", + "type": "gene", + "text": "Determination of diquat in biological materials by electron spin resonance spectroscopy .", + "entities": [] + }, + { + "id": "7821", + "type": "gene", + "text": "The effect of desipramine probably represents inhibition of neuronal uptake and that of amitriptyline and mianserin blockade of neuronal uptake and prejunctional alpha 2 - adrenoreceptors .", + "entities": [ + "alpha 2 - adrenoreceptors" + ] + }, + { + "id": "7822", + "type": "gene", + "text": "Rac causes uncapping of actin filaments ( F - actin ) at the plus - ends , through phosphatidylinositol 4 , 5 bisphosphate ( PIP2 ) , and eventually induces membrane ruffling .", + "entities": [ + "Rac", + "actin filaments", + "F - actin" + ] + }, + { + "id": "7823", + "type": "gene", + "text": "We now describe the identification of DEK as this 43 - kDa pets factor .", + "entities": [ + "DEK", + "43 - kDa pets factor" + ] + }, + { + "id": "7824", + "type": "gene", + "text": "The activity of 6 - fluoroquinolones and their nonfluorinated derivatives is compared in general .", + "entities": [] + }, + { + "id": "7825", + "type": "gene", + "text": "An apparent N - terminal transit peptide in the coding region and a 3 ' poly ( A ) tail exist in the cDNA clone indicated that this chloroplast protein as nuclear encoded .", + "entities": [] + }, + { + "id": "7826", + "type": "gene", + "text": "It is considered that the recurrent annular erythema is a specific skin manifestation of SjS with anti SS - A / SS - B antibodies .", + "entities": [ + "anti SS - A", + "SS - B antibodies" + ] + }, + { + "id": "7827", + "type": "gene", + "text": "Several highly conserved regions were identified at the near N terminus , middle and C terminus .", + "entities": [] + }, + { + "id": "7828", + "type": "gene", + "text": "Standard curve correlation coefficients of 0 . 995 or greater were obtained during validation experiments and analysis of study samples .", + "entities": [] + }, + { + "id": "7829", + "type": "gene", + "text": "Cardiac disease was not detected with M - mode , 2 - dimensional real - time or pulsed - wave Doppler echocardiography .", + "entities": [] + }, + { + "id": "7830", + "type": "gene", + "text": "Recent developments in drugs antagonistic to factors causing peptic ulcer - - clinical efficacy and problems ; gastrin receptor blockaders", + "entities": [ + "gastrin receptor" + ] + }, + { + "id": "7831", + "type": "gene", + "text": "With a sample of mothers of healthy infants , all three subscales of the revised instrument , WPL - R , had acceptable levels of internal consistency at 7 , 30 , and 90 days postpartum , and stability across administrations .", + "entities": [] + }, + { + "id": "7832", + "type": "gene", + "text": "Stringent hybridization of EHS - 1 back to primate genomic DNA indicates two distinct EHS - 1 loci in normal human DNA , an identical band pattern in chimpanzee DNA , and a single locus in rhesus monkey DNA .", + "entities": [ + "EHS - 1", + "EHS - 1 loci" + ] + }, + { + "id": "7833", + "type": "gene", + "text": "This article reports the design and development of an ECG simulator intended for use in the testing , calibration and maintenance of electrocardiographic equipment .", + "entities": [] + }, + { + "id": "7834", + "type": "gene", + "text": "The spectrum of age - associated brain abnormalities : their measurement and histopathological correlates .", + "entities": [] + }, + { + "id": "7835", + "type": "gene", + "text": "On the basis of size , the CRS sequence to which it binds , and its tentative identification as a zinc finger protein , Adx factor has been identified as a Kruppel - like zinc finger protein ( a mouse ZBP - 89 homologue ) .", + "entities": [ + "zinc finger protein", + "Adx factor", + "Kruppel - like zinc finger protein", + "mouse ZBP - 89 homologue" + ] + }, + { + "id": "7836", + "type": "gene", + "text": "Phenazone potentiates the local anaesthetic effect of lidocaine in mice .", + "entities": [] + }, + { + "id": "7837", + "type": "gene", + "text": "Although the molecular mechanisms involved in this regulation are currently being elucidated , very little is known about the trans - acting factors that allow expression of the nitrate and nitrite reductase genes which code for the first enzymes in the pathway .", + "entities": [ + "nitrate and nitrite reductase genes" + ] + }, + { + "id": "7838", + "type": "gene", + "text": "As with the murine and human mb - 1 genes , the 5 ' region of the bovine mb - 1 gene lacked a TATA box .", + "entities": [ + "murine and human mb - 1 genes", + "bovine mb - 1 gene" + ] + }, + { + "id": "7839", + "type": "gene", + "text": "H19 and Igf2 monoallelic expression is regulated in two distinct ways by a shared cis acting regulatory region upstream of H19 .", + "entities": [ + "H19", + "Igf2", + "H19" + ] + }, + { + "id": "7840", + "type": "gene", + "text": "A role for the small GTPase Rac in polyomavirus middle - T antigen - mediated activation of the serum response element and in cell transformation .", + "entities": [ + "small GTPase Rac", + "polyomavirus middle - T antigen" + ] + }, + { + "id": "7841", + "type": "gene", + "text": "The predominant binding activity was not Ets - 1 but rather two independent DNA - protein complexes that comigrated in mobility shift assays .", + "entities": [ + "Ets - 1" + ] + }, + { + "id": "7842", + "type": "gene", + "text": "Blood flow and velocity ( measured using Doppler ultrasound ) gradually decreased during diastole and ultimately reversed in direction as cotyledon resistance was increased up to 14 fold .", + "entities": [] + }, + { + "id": "7843", + "type": "gene", + "text": "In contrast , the deduced amino acid sequence of a second family ( ART5 ) of transferases , cloned from murine lymphoma cells and expressed in high abundance in testis , displays a hydrophobic amino terminus , consistent with a signal sequence , but lacks a hydrophobic signal sequence at its carboxyl terminus , suggesting that the protein is destined for export .", + "entities": [ + "ART5" + ] + }, + { + "id": "7844", + "type": "gene", + "text": "The hp55 gamma protein interacts strongly with the activated IGFIR but not with the kinase - negative mutant receptor .", + "entities": [ + "hp55 gamma protein", + "IGFIR" + ] + }, + { + "id": "7845", + "type": "gene", + "text": "hp55 gamma also interacts with the insulin receptor ( IR ) in the yeast two - hybrid system .", + "entities": [ + "hp55 gamma", + "insulin receptor", + "IR" + ] + }, + { + "id": "7846", + "type": "gene", + "text": "This vector transfected into the yeast Saccharomyces cerevisiae directs expression of a secreted mature protein at levels up to 200 mg of LAPP / liter of culture medium .", + "entities": [] + }, + { + "id": "7847", + "type": "gene", + "text": "Regulation of parathyroid hormone - related protein ( PTHrP ) gene expression .", + "entities": [ + "parathyroid hormone - related protein", + "PTHrP" + ] + }, + { + "id": "7848", + "type": "gene", + "text": "The nucleotide sequence of the region upstream from M . voltae ORFtrpA was determined and revealed the presence of an ORF of 1227 nucleotides ( ORFtrpB ) encoding a 409 amino acid polypeptide of mol .", + "entities": [ + "M . voltae ORFtrpA", + "ORFtrpB" + ] + }, + { + "id": "7849", + "type": "gene", + "text": "wt .", + "entities": [] + }, + { + "id": "7850", + "type": "gene", + "text": "Specific binding of the protein factors to the sites , possibly to the three Mt sequences , may play an important role in the coordinate regulation of the transcription of nuclear genes encoding subunits responsible for mitochondrial oxidative phosphorylation .", + "entities": [] + }, + { + "id": "7851", + "type": "gene", + "text": "Use of the immunofluorescence method for identification of enteroviruses in cell cultures", + "entities": [] + }, + { + "id": "7852", + "type": "gene", + "text": "With a view to identifying other important U14 interactions , a stem - loop domain required for activity of Saccharomyces cerevisiae U14 RNAs ( the Y domain ) was first subjected to detailed mutational analysis .", + "entities": [ + "U14", + "Saccharomyces cerevisiae U14 RNAs" + ] + }, + { + "id": "7853", + "type": "gene", + "text": "This study investigated the degree to which racial identity influences Mexican - Americans ' performance on the L , K , and MF scales of the MMPI - 2 .", + "entities": [] + }, + { + "id": "7854", + "type": "gene", + "text": "Auditory - visual interaction in the generation of saccades in man .", + "entities": [] + }, + { + "id": "7855", + "type": "gene", + "text": "Acute feasibility and safety of a smoking reduction strategy for smokers with schizophrenia .", + "entities": [] + }, + { + "id": "7856", + "type": "gene", + "text": "Propafenone is well tolerated in the majority of young patients .", + "entities": [] + }, + { + "id": "7857", + "type": "gene", + "text": "Binding affinities of these recombinant phages as determined by the retention of these phages by a His - tag immobilized gp17 column , and by co - immunoprecipitation with purified terminase supported the specific nature of the portal protein and terminase interaction sites .", + "entities": [ + "gp17", + "terminase", + "portal protein", + "terminase interaction sites" + ] + }, + { + "id": "7858", + "type": "gene", + "text": "Effect of indoramin in small doses on the central vasomotor loci has been studied in chloralose anesthetized cats by localizing it to the central sites .", + "entities": [] + }, + { + "id": "7859", + "type": "gene", + "text": "Their function is not only to recruit Pho2 to the promoter but to allow cooperative binding of Pho4 together with Pho2 .", + "entities": [ + "Pho2", + "Pho4", + "Pho2" + ] + }, + { + "id": "7860", + "type": "gene", + "text": "Furthermore , microinjection of dominant negative forms of Rac and Cdc42 or of the Rho inhibitor C3 transferase blocked serum - induced DNA synthesis .", + "entities": [ + "Rac", + "Cdc42", + "Rho", + "C3 transferase" + ] + }, + { + "id": "7861", + "type": "gene", + "text": "The mass of UO2 in the extrapulmonary bronchi and first bifurcation decreased more slowly over 0 - - 8 d after inhalation than the corresponding mass on the trachea .", + "entities": [] + }, + { + "id": "7862", + "type": "gene", + "text": "Analysis of proteins synthesized by plasmids containing deleted forms of the trfA region indicates that the A2 protein is the essential trfA - encoded replication protein of plasmid RK2 .", + "entities": [ + "trfA region", + "A2 protein", + "trfA - encoded replication protein" + ] + }, + { + "id": "7863", + "type": "gene", + "text": "4 .", + "entities": [] + }, + { + "id": "7864", + "type": "gene", + "text": "Western blot analyses detect anti - E - specific immunoreactivity in affinity - purified extracts derived from the bacterial expression of a truncated AMPD3 cDNA .", + "entities": [ + "anti - E", + "truncated AMPD3 cDNA" + ] + }, + { + "id": "7865", + "type": "gene", + "text": "In the infected neonates serum alpha - amylase value , as determined by the blue starch method , was only 40 % that of healthy controls ; the mean value of 175 . 1 + / - 64 . 9 IU / l for healthy neonates was significantly higher ( p less than 0 . 0010 ) than the value of 82 . 8 + / - 44 . 4 IU / l for the infected neonates .", + "entities": [ + "alpha - amylase" + ] + }, + { + "id": "7866", + "type": "gene", + "text": "The p73pct1 / p85cdc10 complex binds both in vitro and in vivo to MCB but not SCB or E2F sites .", + "entities": [ + "p73pct1", + "p85cdc10", + "MCB", + "SCB", + "E2F sites" + ] + }, + { + "id": "7867", + "type": "gene", + "text": "Role of estrogen receptor ligand and estrogen response element sequence on interaction with chicken ovalbumin upstream promoter transcription factor ( COUP - TF ) .", + "entities": [ + "estrogen receptor", + "chicken ovalbumin upstream promoter transcription factor", + "COUP - TF" + ] + }, + { + "id": "7868", + "type": "gene", + "text": "Heart rate ( HR ) , rectal temperature ( Tre ) , blood pressure , temperature and relative humidity changes inside clothing were measured on 18 professional firemen ( mean age 29 . 4 + / - 7 . 4 yr , VO2 max 41 . 4 + 8 . 8 ml kg - 1 min - 1 ) wearing fire fighter ' s uniforms ( SU ) or aluminized , fire resistant , impermeable clothing with self contained breathing apparatus ( FE ) .", + "entities": [] + }, + { + "id": "7869", + "type": "gene", + "text": "Amikacin was used in the treatment of 56 serious gram - negative infections in 54 patients of whom 47 survived .", + "entities": [] + }, + { + "id": "7870", + "type": "gene", + "text": "A mixture of human albumin 5 % and hydroxy - ethyl - starch was used as a solution for dilution .", + "entities": [ + "human albumin" + ] + }, + { + "id": "7871", + "type": "gene", + "text": "Response was extremely poor in African Americans and those with HCV genotype 1 .", + "entities": [] + }, + { + "id": "7872", + "type": "gene", + "text": "During early neurogenesis , Vnd protein is restricted to ventral column neuroectoderm and neuroblasts ; later it is detected in a complex pattern of neurons .", + "entities": [ + "Vnd protein" + ] + }, + { + "id": "7873", + "type": "gene", + "text": "Here we present genetic evidence suggesting that PP2A functions downstream of Ras1 in the Sevenless receptor tyrosine kinase ( RTK ) signal transduction pathway that specifies R7 photoreceptor cell fate in the developing Drosophila eye .", + "entities": [ + "PP2A", + "Ras1", + "receptor tyrosine kinase", + "RTK" + ] + }, + { + "id": "7874", + "type": "gene", + "text": "This interaction is reciprocal , since C / EBP dimer binding to a strong C / EBP site leads to enhanced CREB - 1 recruitment to ATF / CREB sites that are weakly bound by CREB .", + "entities": [ + "C / EBP dimer", + "C / EBP site", + "CREB - 1", + "ATF", + "CREB", + "CREB" + ] + }, + { + "id": "7875", + "type": "gene", + "text": "Epitopes of adhesion - perturbing monoclonal antibodies map within a predicted alpha - helical domain of the integrin beta 1 subunit .", + "entities": [ + "integrin beta 1 subunit" + ] + }, + { + "id": "7876", + "type": "gene", + "text": "The transcriptional activity of PPARgamma is positively modulated by ligand binding and negatively regulated by phosphorylation mediated by the MEK / ERK signaling pathway .", + "entities": [ + "PPARgamma", + "MEK", + "ERK" + ] + }, + { + "id": "7877", + "type": "gene", + "text": "An InlC deletion mutant shows reduced virulence when tested in an intravenous mouse model , but intracellular replication of the mutant in Caco - 2 and J774 cells appears to be comparable with that of the wild - type strain .", + "entities": [ + "InlC deletion mutant" + ] + }, + { + "id": "7878", + "type": "gene", + "text": "BACKGROUND : It is generally accepted that smoking increases blood pressure and inhibits muscle sympathetic nerve activity ( SNA ) .", + "entities": [] + }, + { + "id": "7879", + "type": "gene", + "text": "Lowering of the renal blood flow alters the glomerular and tubular excretion processes .", + "entities": [] + }, + { + "id": "7880", + "type": "gene", + "text": "Direct and inverted repeat elements of 10 , 11 , 16 , 19 , and 22 nucleotides ( nt ) flank the promoter site .", + "entities": [] + }, + { + "id": "7881", + "type": "gene", + "text": "CONCLUSIONS : Fission yeast SCF is composed of Pop1 and Pop2 , two structurally related but functionally independent F - box / WD - repeat proteins .", + "entities": [ + "Fission yeast SCF", + "Pop1", + "Pop2", + "F - box / WD - repeat proteins" + ] + }, + { + "id": "7882", + "type": "gene", + "text": "IFI16 consists of ten exons and nine intervening introns spanning at least 28 kilobases ( kb ) of DNA .", + "entities": [ + "IFI16" + ] + }, + { + "id": "7883", + "type": "gene", + "text": "Differential expression of the \" B \" subunit of the vacuolar H ( + ) - ATPase in bovine tissues .", + "entities": [ + "vacuolar H ( + ) - ATPase" + ] + }, + { + "id": "7884", + "type": "gene", + "text": "Treatment of recurrent FSGS has included high - dose steroids , high - dose cyclosporine ( CSA ) , plasmapheresis , and ACE inhibitors with mixed results .", + "entities": [ + "ACE" + ] + }, + { + "id": "7885", + "type": "gene", + "text": "Seventy - two hours after administration of vitamin K1 , plasma concentrations of the vitamin were not different from normal .", + "entities": [] + }, + { + "id": "7886", + "type": "gene", + "text": "The Schizosaccharomyces pombe rad1 + cell cycle checkpoint control gene is required for S - phase and G2 / M arrest in response to both DNA damage and incomplete DNA replication .", + "entities": [ + "Schizosaccharomyces pombe rad1 + cell cycle checkpoint control gene" + ] + }, + { + "id": "7887", + "type": "gene", + "text": "Specifically , I use molecular markers that identify particular neuroectodermal domains , all neuroblasts or individual neuroblasts , to show that in DER mutant embryos ( 1 ) intermediate column neuroblasts do not form , ( 2 ) medial column neuroblasts often acquire identities inappropriate for their position , while ( 3 ) lateral neuroblasts develop normally .", + "entities": [ + "DER mutant" + ] + }, + { + "id": "7888", + "type": "gene", + "text": "Both receptors utilize protein tyrosine kinases ( PTKs ) for the phosphorylation of various signaling molecules , a process that is critical for the function of both receptors .", + "entities": [ + "protein tyrosine kinases", + "PTKs" + ] + }, + { + "id": "7889", + "type": "gene", + "text": "Copper and ceruloplasmin content in pregnant women and in women with certain gynecological diseases", + "entities": [ + "ceruloplasmin" + ] + }, + { + "id": "7890", + "type": "gene", + "text": "We previously described the purification of an 83 - kDa phosphatidic acid phosphatase ( PAP ) from the porcine thymus membranes ( Kanoh , H . , Imai , S . - i . , Yamada , K . and Sakane , F . ( 1992 ) J .", + "entities": [ + "83 - kDa phosphatidic acid phosphatase", + "PAP" + ] + }, + { + "id": "7891", + "type": "gene", + "text": "The records from 1948 through 1967 of 344 previously untreated patients with squamous cell carcinoma of the oral cavity , oropharynx , supraglottic larynx and hypopharynx who had clinically positive cervical lymph node metastases staged N1 , N2A , or N2B , and whose initial neck treatment consisted of external radiation therapy alone were reviewed .", + "entities": [] + }, + { + "id": "7892", + "type": "gene", + "text": "Testing gravity to second post - Newtonian order : A field - theory approach .", + "entities": [] + }, + { + "id": "7893", + "type": "gene", + "text": "This shows that in situations of separated breaks , NHEJ deficiency leads to genomic rearrangements , in agreement with chromosomal studies .", + "entities": [] + }, + { + "id": "7894", + "type": "gene", + "text": "An exon that prevents transport of a mature mRNA .", + "entities": [] + }, + { + "id": "7895", + "type": "gene", + "text": "Oligosynaptic EPSP components were consistently modulated only in the superficial peroneal responses in flexor motoneurons , which exhibited enhanced amplitude during the flexion phase .", + "entities": [] + }, + { + "id": "7896", + "type": "gene", + "text": "Silencing can be restored by creation of a telomere at 13 kb from the reporter construct , or by insertion of 340 bp of yeast telomeric repeat sequence at this site without chromosomal truncation .", + "entities": [] + }, + { + "id": "7897", + "type": "gene", + "text": "The pharmacokinetic patterns of estradiol ( CAS 50 - 28 - 2 ) and of estrone ( CAS 53 - 16 - 7 ) were investigated in 18 women in natural or surgical menopause during the application of a new estradiol transdermal patch with active matrix and without absorption enhancers designed for epicutaneous applications of 7 days ( hereinafter called \" patch 7D \" ) .", + "entities": [] + }, + { + "id": "7898", + "type": "gene", + "text": "Cooperative roles of Bozozok / Dharma and Nodal - related proteins in the formation of the dorsal organizer in zebrafish .", + "entities": [ + "Bozozok", + "Dharma", + "Nodal - related proteins" + ] + }, + { + "id": "7899", + "type": "gene", + "text": "At the end of each day of migration the pulmonary hemolymph PO2 decreased by 1 - 2 . 5 kPa , but the hemocyanin remained saturated with O2 and the venous reserve was largely unchanged ( O2 > 0 . 4 mmol x l ( - 1 ) ) .", + "entities": [] + }, + { + "id": "7900", + "type": "gene", + "text": "Endovascular aneurysm repair with the AneuRx stent - graft is safe , but is it effective ?", + "entities": [] + }, + { + "id": "7901", + "type": "gene", + "text": "Uracil DNA glycosylase catalyzes the initial step in the repair pathway that removes potentially mutagenic uracil from duplex DNA .", + "entities": [ + "Uracil DNA glycosylase" + ] + }, + { + "id": "7902", + "type": "gene", + "text": "The concentration of mite allergen was very low ( mean 0 . 18 micrograms Der p milligrams sieved house dust ) , whereas that of cat allergen was high in homes with a cat ( 80 . 8 micrograms Fel d milligrams ) but also in homes with no cat ( 3 . 2 micrograms Fel d milligrams ) .", + "entities": [] + }, + { + "id": "7903", + "type": "gene", + "text": "The Cr . psbA - 4 ORF contains an H - N - H motif , and possibly a GIY - YIG motif .", + "entities": [ + "Cr . psbA - 4 ORF" + ] + }, + { + "id": "7904", + "type": "gene", + "text": "Isolation of T . gambiense strains in Zaire and their adaptation to laboratory animals", + "entities": [] + }, + { + "id": "7905", + "type": "gene", + "text": "A patient of Group B had severe athetoid CP with spasticity , being unable to right his trunk and neck .", + "entities": [] + }, + { + "id": "7906", + "type": "gene", + "text": "The subgroup innervating the medial rectus lies exclusively along the medial face of the oculomotor nucleus , with no aberrant neurons in the medial longitudinal fasciculus , as have been found in other mammals .", + "entities": [] + }, + { + "id": "7907", + "type": "gene", + "text": "The use of highly active antiretroviral therapy ( HAART ) has resulted in significant improvements in the treatment of HIV infection , including a decrease in the incidence and severity of several acquired immune deficiency syndrome ( AIDS ) - related malignancies .", + "entities": [] + }, + { + "id": "7908", + "type": "gene", + "text": "Hepatitis B and liver transplantation .", + "entities": [] + }, + { + "id": "7909", + "type": "gene", + "text": "Combined therapy with MK - 801 and nimodipine for protection of ischemic brain damage .", + "entities": [] + }, + { + "id": "7910", + "type": "gene", + "text": "The students who had abnormal urine screening results at the first time received a second urine analysis 10 to 15 days later to confirm the abnormal urine analysis .", + "entities": [] + }, + { + "id": "7911", + "type": "gene", + "text": "These losses account for the resistance of EDS - IV collagen to cyanogen bromide and mammalian collagenase digestion .", + "entities": [ + "collagen", + "mammalian collagenase" + ] + }, + { + "id": "7912", + "type": "gene", + "text": "Heterodimers of myogenin and E12 ( or MyoD and E12 ) specifically bound a restriction fragment extending from - 200 to - 103 relative to the start of cardiac alpha - actin transcription .", + "entities": [ + "myogenin", + "E12", + "MyoD", + "E12", + "cardiac alpha - actin" + ] + }, + { + "id": "7913", + "type": "gene", + "text": "To define the minimal VDRE binding domain for human VDR ( hVDR ) , a series of C - terminally truncated hVDR mutants ( Delta134 , Delta113 , Delta102 , Delta90 , Delta84 , Delta80 , and Delta60 ) was generated and expressed in bacteria .", + "entities": [ + "human VDR", + "hVDR", + "hVDR mutants" + ] + }, + { + "id": "7914", + "type": "gene", + "text": "We identify considerable spatio - temporal similarities between reported expression patterns of Ypr10 genes and ribonuclease genes , which , together with the significant sequence similarity to the ginseng ribonuclease , support the hypothesis of a ribonuclease function for PR - 10 proteins and allow the prediction of possible biological roles .", + "entities": [ + "Ypr10 genes", + "ginseng ribonuclease", + "PR - 10 proteins" + ] + }, + { + "id": "7915", + "type": "gene", + "text": "The mean body mass index ( BMI ) was 31 . 8 + / - 6 . 3 kg / m2 and 28 . 5 + / - 6 . 3 kg / m2 in women and men , respectively .", + "entities": [] + }, + { + "id": "7916", + "type": "gene", + "text": "1st data on the immunosuppressive therapy of scleroderma", + "entities": [] + }, + { + "id": "7917", + "type": "gene", + "text": "To measure the enhancer activity of DR60 , a reporter plasmid was constructed that contained DR60 cloned upstream of the reporter chloramphenicol acetyltransferase gene under the control of the delayed - early 39K promoter .", + "entities": [ + "DR60", + "DR60", + "chloramphenicol acetyltransferase gene" + ] + }, + { + "id": "7918", + "type": "gene", + "text": "Partial engorgement was higher in the treatments .", + "entities": [] + }, + { + "id": "7919", + "type": "gene", + "text": "IL - 12 production was correlated with C3a concentration measured at the outlet of hemodialyzer after 15 min of dialysis ( r = 0 . 69 , P < 0 . 01 ) .", + "entities": [ + "IL - 12" + ] + }, + { + "id": "7920", + "type": "gene", + "text": "PRL receptor also activates SHP - 2 , a cytosolic tyrosine phosphatase .", + "entities": [ + "PRL receptor", + "SHP - 2", + "cytosolic tyrosine phosphatase" + ] + }, + { + "id": "7921", + "type": "gene", + "text": "In a second series of experiments , the efficacy of PDC / HDC Ac was evaluated in both single and multiple dose regiments .", + "entities": [] + }, + { + "id": "7922", + "type": "gene", + "text": "The ultrastructural findings , as well as the urinary C - peptide excretion , confirmed that the glycemic effects should not be thought to be due to a direct action of the drugs used on the endocrine pancreas .", + "entities": [ + "C - peptide" + ] + }, + { + "id": "7923", + "type": "gene", + "text": "Expression of the human heat shock protein 70 gene ( hsp70 ) is induced by various kinds of stress and by oncogenes .", + "entities": [ + "human heat shock protein 70 gene", + "hsp70" + ] + }, + { + "id": "7924", + "type": "gene", + "text": "Those radiological aspects were distributed in two categories : 1 ) type I - presenting variable sinusoidal filling .", + "entities": [] + }, + { + "id": "7925", + "type": "gene", + "text": "This unique work needs to be edited critically and afterwards translated into Urdu and other languages for the benefit of the present day students and scholars .", + "entities": [] + }, + { + "id": "7926", + "type": "gene", + "text": "We conclude that c - Abl activates c - myc transcription indirectly with no requirement for DNA binding by c - Abl .", + "entities": [ + "c - Abl", + "c - myc", + "c - Abl" + ] + }, + { + "id": "7927", + "type": "gene", + "text": "After an initial titration period and adjustment of the therapeutic dose , the individual doses were from 21 to 500 micrograms / 24 hrs ( mean 160 micrograms / 24 hrs ) .", + "entities": [] + }, + { + "id": "7928", + "type": "gene", + "text": "HNF - 3 beta amino - terminal sequences defined by conserved region IV also contributed to transactivation , but region IV activity required the participation of the region II - III domain .", + "entities": [ + "HNF - 3 beta amino - terminal sequences" + ] + }, + { + "id": "7929", + "type": "gene", + "text": "The ability of spt2 mutations to suppress the transcriptional interference caused by the delta promoter insertion his - 4 - 912 delta correlates with an increase in wild - type HIS4 mRNA levels .", + "entities": [ + "spt2 mutations", + "delta promoter insertion his - 4 - 912 delta", + "wild - type HIS4 mRNA" + ] + }, + { + "id": "7930", + "type": "gene", + "text": "Epidemiology and prevention of hospital infections in the Local Health Unit of Sassari : profile of bacterial resistance and antimicrobial agents of large usage .", + "entities": [] + }, + { + "id": "7931", + "type": "gene", + "text": "Inhibition of the apolipoprotein B mRNA editing enzyme - complex by hnRNP C1 protein and 40S hnRNP complexes .", + "entities": [ + "apolipoprotein B mRNA", + "hnRNP C1 protein", + "40S hnRNP complexes" + ] + }, + { + "id": "7932", + "type": "gene", + "text": "NiCl ( 2 ) - induced MCP - 1 synthesis required activation of NF - kappaB since mutation of NF - kappaB - binding sites in the promoter resulted in complete loss of inducible promoter activity .", + "entities": [ + "MCP - 1", + "NF - kappaB", + "NF - kappaB - binding sites" + ] + }, + { + "id": "7933", + "type": "gene", + "text": "Thirty cadaver brains were examined under X 6 to 16 magnification in order to define the microsurgical anatomy of the pineal region , particularly the relationship of the pineal body , posterior cerebral artery , superior cerebellar artery , vein of Galen , basal vein of Rosenthal , internal cerebral vein , straight sinus , bridging vein , the size of the tentorial notch , and the third and the fourth cranial nerves .", + "entities": [] + }, + { + "id": "7934", + "type": "gene", + "text": "Another mutant , T255A , lost the ability to bind E4orf6 , but unexpectedly , viral late - gene expression was not affected .", + "entities": [ + "E4orf6" + ] + }, + { + "id": "7935", + "type": "gene", + "text": "The ORFII gene product is targeted to the chloroplast , which is consistent with previous data indicating the presence of PMSR activity in the chloroplast .", + "entities": [ + "ORFII gene product", + "PMSR" + ] + }, + { + "id": "7936", + "type": "gene", + "text": "Bacterial meningitis secondary to abscess of the nasal septum .", + "entities": [] + }, + { + "id": "7937", + "type": "gene", + "text": "Heterogeneous electron transfer of cytochrome c facilitated by polypyrrole and methylene blue polypyrrole film modified electrodes .", + "entities": [ + "cytochrome c" + ] + }, + { + "id": "7938", + "type": "gene", + "text": "The pathophysiology and clinical management of acute brain injury in infancy and childhood are presented using acute traumatic brain injury as a model .", + "entities": [] + }, + { + "id": "7939", + "type": "gene", + "text": "The relative toxicity of nickel oxide ( NiO ) , nickel sulfate hexahydrate ( NiSO4 . 6H2O ) , and nickel subsulfide ( Ni3S2 ) was studied in F344 / N rats and B6C3F1 mice after inhalation exposure for 6 hr / day , 5 days / week , for 13 weeks .", + "entities": [] + }, + { + "id": "7940", + "type": "gene", + "text": "When BFDS was taken as the reference , W / A Z scores showed consistent positive increments , from birth in girls and 1 mo in boys .", + "entities": [] + }, + { + "id": "7941", + "type": "gene", + "text": "We measured basal plasma prolactin concentrations ( in samples obtained during the early follicular phase ) in 25 normal ( control ) women and in a similar group of 40 patients with a long - standing history of infertility .", + "entities": [ + "prolactin" + ] + }, + { + "id": "7942", + "type": "gene", + "text": "Antibodies affinity - purified using the bacterially expressed recombinant protein recognized the 56K autoantigen in a HeLa cell extract .", + "entities": [ + "56K autoantigen" + ] + }, + { + "id": "7943", + "type": "gene", + "text": "cDNA sequencing revealed that the 56K cDNA shares a high degree of homology in both nucleotide ( 87 % ) and amino acid sequence ( 92 . 5 % ) with bovine annexin XI , indicating that the 56K cDNA encodes the human homologue of annexin XI , a member of the Ca ( 2 + ) - dependent phospholipid binding protein family .", + "entities": [ + "56K cDNA", + "bovine annexin XI", + "56K cDNA", + "human homologue of annexin XI", + "Ca ( 2 + ) - dependent phospholipid binding protein family" + ] + }, + { + "id": "7944", + "type": "gene", + "text": "In addition to its elongation activity , ELL contains a novel type of RNA polymerase II interaction domain that is capable of repressing polymerase activity in promoter - specific transcription .", + "entities": [ + "ELL", + "RNA polymerase II interaction domain" + ] + }, + { + "id": "7945", + "type": "gene", + "text": "Studies suggest that the DGOR without acid reflux may result in symptoms but unless acid reflux is present simultaneously , it does not cause oesophagitis .", + "entities": [] + }, + { + "id": "7946", + "type": "gene", + "text": "Acquired antithrombin deficiency in sepsis .", + "entities": [ + "antithrombin" + ] + }, + { + "id": "7947", + "type": "gene", + "text": "59 cases of surgically resectable cancers ( T1 , T2 , T3 , N0 , N1 ) had a minimum followup of two years ( average 4 years + / - 3 months ) .", + "entities": [] + }, + { + "id": "7948", + "type": "gene", + "text": "This rapid and extensive penetration of intrathecally administered chemotherapy may offer insight into the myelopathy observed with these treatments .", + "entities": [] + }, + { + "id": "7949", + "type": "gene", + "text": "The evaluation of amniotic fluid delta OD450 is considered to be the cornerstone of clinical management .", + "entities": [] + }, + { + "id": "7950", + "type": "gene", + "text": "Dotarizine produced arterial dilation in both systemic and pulmonary circulation : the total peripheral resistance dropped , and femoral artery flow rose ; aortic and pulmonary artery mean and diastolic pressures declined , and systolic pressures remained almost stable .", + "entities": [] + }, + { + "id": "7951", + "type": "gene", + "text": "Patients received either diltiazem CD 180 mg or placebo once / day in combination with existing antianginal therapy .", + "entities": [] + }, + { + "id": "7952", + "type": "gene", + "text": "When combined with independent activating mutations in the c - abl kinase domain or NH2 - terminus , the G128R mutation blocked transformation by the double mutant , suggesting that the G128R mutant was unable to transform cells for trivial reasons .", + "entities": [ + "c - abl kinase domain", + "G128R", + "G128R mutant" + ] + }, + { + "id": "7953", + "type": "gene", + "text": "Transactivation of naturally occurring HIV - 1 long terminal repeats by the JNK signaling pathway .", + "entities": [ + "HIV - 1 long terminal repeats", + "JNK" + ] + }, + { + "id": "7954", + "type": "gene", + "text": "Three pyridoxine derivatives have been isolated from the fresh stem bark of Albizzia julibrissin DURAZZ . .", + "entities": [] + }, + { + "id": "7955", + "type": "gene", + "text": "Growth hormone and insulin - like growth factor I receptors in the temporomandibular joint of the rat .", + "entities": [ + "Growth hormone", + "insulin - like growth factor I receptors" + ] + }, + { + "id": "7956", + "type": "gene", + "text": "Isolation of Proteus vulgaris MC - 63 from carcinoma 63 and its antitumor effect on Crocker sarcoma 180 and Ehrlich carcinoma .", + "entities": [] + }, + { + "id": "7957", + "type": "gene", + "text": "When the first twitch of TOF spontaneously recovered to 10 % of control value , neostigmine was injected ( 40 micrograms / kg in adults , 30 micrograms / kg in infants and children ) .", + "entities": [] + }, + { + "id": "7958", + "type": "gene", + "text": "We cloned a complete cDNA ( 2 . 9 kb ) for HET from an MCF - 7 cDNA library .", + "entities": [ + "HET" + ] + }, + { + "id": "7959", + "type": "gene", + "text": "Likewise , whether or not the hypotensive action of converting enzyme inhibitors is age - related is as yet unknown .", + "entities": [] + }, + { + "id": "7960", + "type": "gene", + "text": "Thyreoliberin VUFB in thyroid gammagraphy", + "entities": [ + "Thyreoliberin" + ] + }, + { + "id": "7961", + "type": "gene", + "text": "This R - domain may modulate the interaction with SRF , providing a mechanism that would be unique to FLI1 and EWS - FLI1 , thus implicating a novel function for these ETS transcription factors in the regulation of the Egr1 gene .", + "entities": [ + "SRF", + "FLI1", + "EWS", + "FLI1", + "ETS transcription factors", + "Egr1 gene" + ] + }, + { + "id": "7962", + "type": "gene", + "text": "Cyclins are one of the pivotal determinants regulating cell cycle progression .", + "entities": [ + "Cyclins" + ] + }, + { + "id": "7963", + "type": "gene", + "text": "Analysis of RAR alpha mutants in transfection studies reveals that the DNA binding domain is sufficient for inhibition of BZLF1 activity .", + "entities": [ + "RAR alpha mutants", + "BZLF1" + ] + }, + { + "id": "7964", + "type": "gene", + "text": "Simian parainfluenza virus 5 ( SV5 ) is a prototype of the Paramyxoviridae family of nonsegmented negative - sense RNA viruses .", + "entities": [] + }, + { + "id": "7965", + "type": "gene", + "text": "A DNA fragment encoding the DNA - binding domain ( amino acids 1 - 60 ) of the Escherichia coli fru transcriptional regulator was cloned into the pGEX - KT vector and expressed in frame with the fused gene encoding glutathione S - transferase .", + "entities": [ + "Escherichia coli fru transcriptional regulator", + "glutathione S - transferase" + ] + }, + { + "id": "7966", + "type": "gene", + "text": "A hybridoma clone ( 7H1 ) resulting from the fusion between CEMLAI / NP and human embryonic fibroblasts MRC5 cells produced very large amounts of P47 that was purified using Jacalin lectin ( specific for O - glycans ) and microsequenced .", + "entities": [ + "P47", + "Jacalin lectin" + ] + }, + { + "id": "7967", + "type": "gene", + "text": "In the course of Hepatitis A HBs - and HBe - antigen as well as HBc ( IgM and IgG ) - , HBs - and HBe - antibodies can be detected .", + "entities": [ + "Hepatitis A HBs - and HBe - antigen", + "HBc ( IgM and IgG ) - , HBs - and HBe - antibodies" + ] + }, + { + "id": "7968", + "type": "gene", + "text": "Mutational analysis of the L1 binding site of 23S rRNA in Escherichia coli .", + "entities": [ + "L1 binding site", + "23S rRNA in Escherichia coli" + ] + }, + { + "id": "7969", + "type": "gene", + "text": "Seventy - five percent of children who received a second transplant for HCV hepatitis had early histologic recurrence that led to liver failure and death .", + "entities": [] + }, + { + "id": "7970", + "type": "gene", + "text": "A human Raf - responsive zinc - finger protein that binds to divergent sequences .", + "entities": [ + "human Raf - responsive zinc - finger protein" + ] + }, + { + "id": "7971", + "type": "gene", + "text": "Tissue samples were obtained either from rats that had been exposed to opiate withdrawal following a seven day morphine infusion or sham treated control subjects .", + "entities": [] + }, + { + "id": "7972", + "type": "gene", + "text": "Together , these results indicate that IL - 1 beta induces VEGF gene expression at both transcriptional and post - transcriptional levels , and IL - 1 beta evokes p38 MAPK and JNK signalings , which in turn stimulate the transcription of the VEGF gene through Sp1 - binding sites .", + "entities": [ + "IL - 1 beta", + "VEGF gene", + "IL - 1 beta", + "p38", + "JNK", + "VEGF gene", + "Sp1 - binding sites" + ] + }, + { + "id": "7973", + "type": "gene", + "text": "The rhabdomyosarcoma R1H growing on the right flank of male WAG / Rij rats was clamped for 2 or 4 h at 20 degrees C or 37 degrees C .", + "entities": [] + }, + { + "id": "7974", + "type": "gene", + "text": "The IA4 mAb was identified among a series of antibodies raised in BALB / c mice after immunization against a HLA class I - deficient , lymphokine - activated killer ( LAK ) - susceptible EBV - B lymphocyte line .", + "entities": [ + "IA4 mAb", + "HLA" + ] + }, + { + "id": "7975", + "type": "gene", + "text": "Thus , while the genomic organization of mHuA is similar to the neural - restricted members of the Elav family , the promoter element differs substantially both by sequence analysis and transcriptional activity in non - neural cell types .", + "entities": [ + "mHuA", + "Elav family" + ] + }, + { + "id": "7976", + "type": "gene", + "text": "Four of these five subjects also performed mixed sequences under conditional control of the words ( e . g . , A1 - - - - B2 - - - - A3 - - - - B4 - - - - A5 and its reversal ) , verifying that the stimuli which occupied the same position in each sequence were members of the same class .", + "entities": [] + }, + { + "id": "7977", + "type": "gene", + "text": "L3 - L4 compressive load was calculated using a model of the anatomy of the trunk musculoskeletal system .", + "entities": [] + }, + { + "id": "7978", + "type": "gene", + "text": "A sequence representing about 50 % of the expected complete sequence was obtained by translation of the two open reading frames present on a 1 . 6 kb DNA genomic fragment .", + "entities": [] + }, + { + "id": "7979", + "type": "gene", + "text": "McCann III , F .", + "entities": [] + }, + { + "id": "7980", + "type": "gene", + "text": "The relationships among blood concentrations of thyroid hormones and selenium , zinc , retinol , and alpha - tocopherol were studied in 44 healthy Northern Italian oldest - old subjects ( age range , 90 - 107 yr ) , selected by the criteria of the SENIEUR protocol .", + "entities": [] + }, + { + "id": "7981", + "type": "gene", + "text": "Eight highly trained male kayakers were studied to determine the relationship between critical power ( CP ) and the onset of blood lactate accumulation ( OBLA ) .", + "entities": [] + }, + { + "id": "7982", + "type": "gene", + "text": "Mutant enzyme forms were prepared to eliminate the initial autoprocessing site and thus form an active single - chain protein for structure - function studies .", + "entities": [] + }, + { + "id": "7983", + "type": "gene", + "text": "The COOH - terminus of this new isoform , which we designate beta 4 , lacks a 22 amino acid lysine - rich sequence common to both the human red cell alpha - and beta - adducin subunits and homologous to a highly conserved region in MARCKS , a filamentous actin - cross linking protein regulated by protein kinase C and calcium / calmodulin . beta 4 - adducin preserves a previously identified calmodulin binding domain .", + "entities": [ + "beta 4", + "human red cell alpha - and beta - adducin subunits", + "MARCKS", + "actin", + "protein kinase C", + "calmodulin", + "beta 4 - adducin", + "calmodulin binding domain" + ] + }, + { + "id": "7984", + "type": "gene", + "text": "Covalent modification of the transactivator protein IE2 - p86 of human cytomegalovirus by conjugation to the ubiquitin - homologous proteins SUMO - 1 and hSMT3b .", + "entities": [ + "IE2", + "p86", + "SUMO - 1", + "hSMT3b" + ] + }, + { + "id": "7985", + "type": "gene", + "text": "The BAL concentrations of the nine cytokines evaluated for the more and less affected lungs were compared : interleukin - 6 ( IL - 6 ) , IL - 8 , IL - 12 , tumor necrosis factor - alpha ( TNF - alpha ) , and interferon gamma ( IFN - gamma ) showed significant differences ( p ranged between 0 .", + "entities": [ + "interleukin - 6", + "IL - 6", + "IL - 8", + "IL - 12", + "tumor necrosis factor - alpha", + "TNF - alpha", + "interferon gamma", + "IFN - gamma" + ] + }, + { + "id": "7986", + "type": "gene", + "text": "These are the long terminal repeat ( LTR ) promoter , which regulates expression of the viral structural proteins , and a second internal promoter , located towards the 3 ' end of the env gene , that directs expression of the viral auxiliary proteins .", + "entities": [ + "env gene" + ] + }, + { + "id": "7987", + "type": "gene", + "text": "No reflow occurred in approximately 30 percent of the muscle microvasculature upon reperfusion .", + "entities": [] + }, + { + "id": "7988", + "type": "gene", + "text": "When desipramine was injected 16 hrs after fluoxetine injection , brain levels of desipramine were no longer elevated .", + "entities": [] + }, + { + "id": "7989", + "type": "gene", + "text": "Catheter transit slows the response to a step increase in concentration by about 0 . 13 s ( from 10 per cent - 90 per cent ) and prolongs the transit time through the catheter for a volatile anesthetic by about 0 . 04 s more than N2 .", + "entities": [] + }, + { + "id": "7990", + "type": "gene", + "text": "The range of eosinophils was 22 - 56 % of the number of peripheral white blood cells ( mean nadir 33 % ) .", + "entities": [] + }, + { + "id": "7991", + "type": "gene", + "text": "The reduction in saturated fatty acids intake led to modest ( but in group 1 significant ) 0 . 15 mmol / l ( 2 . 5 % ) reduction in total serum cholesterol level .", + "entities": [] + }, + { + "id": "7992", + "type": "gene", + "text": "Environmental factors were more important in the older cohorts ( perhaps because of less reliable recall ) .", + "entities": [] + }, + { + "id": "7993", + "type": "gene", + "text": "For signal durations less than 10 ms , however , the SoNo and S pi No threshold functions converged and the masking - level difference decreased .", + "entities": [] + }, + { + "id": "7994", + "type": "gene", + "text": "Recent molecular analysis has revealed that the S locus is highly polymorphic and contains several genes , i . e . , SLG , SRK , the as - yet - unidentified pollen S gene ( s ) , and other linked genes .", + "entities": [ + "S locus", + "SLG", + "SRK", + "pollen S gene ( s )" + ] + }, + { + "id": "7995", + "type": "gene", + "text": "But , as Theriault explains , improvements in assessing exposure have not yet translated into clear and consistent findings .", + "entities": [] + }, + { + "id": "7996", + "type": "gene", + "text": "We suggest that sensitivity to photoperiod in pallid bats , as in several other mammals , is mediated by the pineal gland .", + "entities": [] + }, + { + "id": "7997", + "type": "gene", + "text": "Our results indicate that V3 peptides from all major clades of HIV - 1 carried by HIV - 2 gag can be used as a potential HIV / AIDS vaccine .", + "entities": [ + "V3", + "HIV - 2 gag" + ] + }, + { + "id": "7998", + "type": "gene", + "text": "Studies on alcoholic liver injury .", + "entities": [] + }, + { + "id": "7999", + "type": "gene", + "text": "The murine mutation dominant white spotting ( W ) is in the proto - oncogene , c - kit .", + "entities": [ + "murine mutation dominant white spotting", + "W", + "c - kit" + ] + }, + { + "id": "8000", + "type": "gene", + "text": "The first involved measurements of the steady state levels of mRNAs for subunit 5 of cytochrome oxidase and the beta subunit of F1 ATPase in wild type and in a hem2 mutant .", + "entities": [ + "cytochrome oxidase", + "F1 ATPase", + "hem2 mutant" + ] + }, + { + "id": "8001", + "type": "gene", + "text": "Capsular antigens of Staphylococcus aureus", + "entities": [] + }, + { + "id": "8002", + "type": "gene", + "text": "Localization of the cytokine response element by 5 ' - deletion analysis and site - directed mutagenesis revealed a cis - acting binding site for activated STAT complexes .", + "entities": [ + "STAT" + ] + }, + { + "id": "8003", + "type": "gene", + "text": "Using in organello footprint analysis , we demonstrate that within human placental mitochondria there is a high level of protein - DNA binding at regularly phased intervals throughout a 500 - bp region encompassing the D - loop DNA origins and two promoter regions .", + "entities": [] + }, + { + "id": "8004", + "type": "gene", + "text": "The sequence up to - 267 bp relative to the transcription start site was sufficient to enhance reporter gene expression depending on the mesodermal differentiation of P19 cells .", + "entities": [] + }, + { + "id": "8005", + "type": "gene", + "text": "17 volunteer deaf Ss were compared with 18 volunteer hearing Ss on the Stanford Hypnotic Clinical Scale ( SHCS ) of Morgan and J .", + "entities": [] + }, + { + "id": "8006", + "type": "gene", + "text": "There were no instances of major flap necrosis although two flaps showed tip ischaemia .", + "entities": [] + }, + { + "id": "8007", + "type": "gene", + "text": "CDC31 is required for SPB duplication and encodes a calmodulin - like protein that is most closely related to caltractin / centrin , a protein associated with the Chlamydomonas basal body .", + "entities": [ + "CDC31", + "calmodulin - like protein", + "caltractin", + "centrin" + ] + }, + { + "id": "8008", + "type": "gene", + "text": "The decrease in left ventricular ( LV ) stroke volume during positive end - expiratory pressure ( PEEP ) has been attributed to reduced LV filling and a decreased contractile state .", + "entities": [] + }, + { + "id": "8009", + "type": "gene", + "text": "When a tumour is present nipple discharge is of little importance for the diagnosis and treatment .", + "entities": [] + }, + { + "id": "8010", + "type": "gene", + "text": "Constantly rectilinear pressure curves without uterine activities are interpreted as characteristic tocographic criteria of an advanced ectopic gravidity .", + "entities": [] + }, + { + "id": "8011", + "type": "gene", + "text": "Syndecan - 4 is a focal adhesion component , and this interaction may both localize PKC and amplify its activity at sites of forming adhesions .", + "entities": [ + "Syndecan - 4", + "PKC" + ] + }, + { + "id": "8012", + "type": "gene", + "text": "Tolerance to ADAL - 2 was similar to that of Vicryl suture and tolerance to ADAL - 2 was superior to that to Tisuacryl .", + "entities": [] + }, + { + "id": "8013", + "type": "gene", + "text": "RNA of GBV - C was detected in 14 ( 18 % ) patients before BMT .", + "entities": [] + }, + { + "id": "8014", + "type": "gene", + "text": "No symptomatic abnormality has been noted in the neonatal period except periventricular calcifications .", + "entities": [] + }, + { + "id": "8015", + "type": "gene", + "text": "Liquid chromatographic separation was achieved on a Zorbax RX C8 analytical column using gradient elution .", + "entities": [] + }, + { + "id": "8016", + "type": "gene", + "text": "The scr regulon of pUR400 and the chromosomally encoded scr regulon of Klebsiella pneumoniae KAY2026 are both negatively controlled by a specific repressor ( ScrR ) .", + "entities": [ + "scr regulon", + "chromosomally encoded scr regulon of Klebsiella pneumoniae KAY2026", + "ScrR" + ] + }, + { + "id": "8017", + "type": "gene", + "text": "Mutations in the small subunit of ribulosebisphosphate carboxylase affect subunit binding and catalysis .", + "entities": [ + "ribulosebisphosphate carboxylase" + ] + }, + { + "id": "8018", + "type": "gene", + "text": "These results suggest that the negative inotropic action of nicorandil is caused by inhibition of Ca influx and intracellular mobilization of Ca .", + "entities": [] + }, + { + "id": "8019", + "type": "gene", + "text": "Sexually conditioned incentives : attenuation of motivational impact during dopamine receptor antagonism .", + "entities": [ + "dopamine receptor" + ] + }, + { + "id": "8020", + "type": "gene", + "text": "Mechanism of the t ( 14 ; 18 ) chromosomal translocation : structural analysis of both derivative 14 and 18 reciprocal partners .", + "entities": [] + }, + { + "id": "8021", + "type": "gene", + "text": "We then studied four unrelated Japanese families with GSD - Ib , and found three novel mutations : a four - base deletion / two - base insertion , a point mutation within a consensus splicing donor site , and a missense mutation ( W118R ) .", + "entities": [] + }, + { + "id": "8022", + "type": "gene", + "text": "At different times of the surgical procedures ( thorax opening and closure , period of cardiopulmonary bypass ) 67 to 100 % of the patients in group 1 had vancomycin concentrations in the studied tissues above the MIC 90 for Staphylococcus aureus ( 1 microgram / g ) and Staphylococcus epidermidis ( 2 micrograms / g ) .", + "entities": [] + }, + { + "id": "8023", + "type": "gene", + "text": "This study was performed to assess the role of additional diagnostic laparoscopy in the preoperative staging of patients with adenocarcinoma of the esophagus , gastric cancer and pancreatic cancer prior to intended curative surgery .", + "entities": [] + }, + { + "id": "8024", + "type": "gene", + "text": "In insects , arylalkylamine N - acetyltransferases ( AANATs ) have been implicated in several physiological processes , including sclerotization , inactivation of certain neurotransmitters , and , similar to the function in vertebrates , catalysis of the rate - limiting step in melatonin biosynthesis .", + "entities": [ + "arylalkylamine N - acetyltransferases", + "AANATs" + ] + }, + { + "id": "8025", + "type": "gene", + "text": "The flow rate of phosphate buffered saline through dermis was measured as a function of applied pressure .", + "entities": [] + }, + { + "id": "8026", + "type": "gene", + "text": "Processivity of DNA synthesis by the mutant holoenzyme containing pcna - 79 was unaffected on poly ( dA ) x oligo ( dT ) but was dramatically reduced on a natural template with secondary structure .", + "entities": [ + "pcna - 79" + ] + }, + { + "id": "8027", + "type": "gene", + "text": "The effect of the fatty acid cyclo - oxygenase inhibitor indomethacin on cerebral blood flow ( CBF ) and the metabolic rate for oxygen ( CMRO2 ) was studied in paralyzed and artificially ventilated rats .", + "entities": [ + "fatty acid cyclo - oxygenase" + ] + }, + { + "id": "8028", + "type": "gene", + "text": "We evaluated regional right ventricular wall motion during systole in patients with surgically repaired tetralogy of Fallot ( TOF ) using color kinesis imaging .", + "entities": [] + }, + { + "id": "8029", + "type": "gene", + "text": "In contrast , deletion of the upstream portion of the delta promoter led to a 10 fold decrease in expression .", + "entities": [] + }, + { + "id": "8030", + "type": "gene", + "text": "METHODS AND RESULTS : Palmaz - Schatz stents were dip - coated with paclitaxel ( 0 , 0 . 2 , 15 , or 187 microgram / stent ) by immersion in ethanolic paclitaxel and evaporation of the solvent .", + "entities": [] + }, + { + "id": "8031", + "type": "gene", + "text": "The effect of diffusion limitation was quantified in terms of the ratio O2 uptake / O2 requirement ( = fraction of cross - sectional area supplied with O2 ) , assuming local O2 requirement per unit volume to be constant and independent of PO2 at PO2 greater than 0 .", + "entities": [] + }, + { + "id": "8032", + "type": "gene", + "text": "Sequence analysis of this region revealed three eight - bp repetitive elements , the deletion of which restored wild - type levels of luciferase activity to the - 916 - bp reporter plasmid .", + "entities": [ + "luciferase" + ] + }, + { + "id": "8033", + "type": "gene", + "text": "The introduction of an acidic residue at the second site was essential for suppression of the Asn - 285 mutation because Lys - 220 and Gln - 220 second - site mutants of the Asn - 285 mutant showed very low tetracycline resistance . ( ABSTRACT TRUNCATED AT 250 WORDS )", + "entities": [] + }, + { + "id": "8034", + "type": "gene", + "text": "Moreover , the mass estimated with the QCM response through the Sauerbrey equation and the mass which can be measured thanks to other analytical techniques , in our case an enzymatic assay , are different : the deposited mass is generally overestimated by the QCM .", + "entities": [] + }, + { + "id": "8035", + "type": "gene", + "text": "These included HNF - 3 beta , HFH - 1 , HFH - 2 , HFH - 3 , C / EBP , and C / EBP beta , all of which are consistent with the tissue - specific expression profiles of the gene .", + "entities": [ + "HNF - 3 beta", + "HFH - 1", + "HFH - 2", + "HFH - 3", + "C / EBP", + "C / EBP beta" + ] + }, + { + "id": "8036", + "type": "gene", + "text": "The promoter activity was measured by a transient expression of a chloramphenicol acetyltransferase ( CAT ) gene connected with various 5 ' - deletion mutants of the 5 ' - flanking region .", + "entities": [ + "chloramphenicol acetyltransferase", + "CAT" + ] + }, + { + "id": "8037", + "type": "gene", + "text": "Taken together , these data indicate that the VirD2 omega domain is important for efficient T - DNA integration .", + "entities": [ + "VirD2 omega domain" + ] + }, + { + "id": "8038", + "type": "gene", + "text": "In addition , and in support of a mediating role of STATs in the activation of the p21 promoter , overexpression of Stat3 potentiated the cytokine effect on the p21 promoter ; whereas a dominant negative Stat3 , or a mutation of the STAT response element on the promoter , significantly reduced the cytokine effect .", + "entities": [ + "STATs", + "p21 promoter", + "Stat3", + "p21 promoter", + "dominant negative Stat3", + "STAT response element" + ] + }, + { + "id": "8039", + "type": "gene", + "text": "The major type involves activator proteins that bind to DNA adjacent to where the RNA polymerase ( RNAP ) holoenzyme binds , usually assisting in recruitment of the RNAP to the promoter .", + "entities": [ + "RNA polymerase", + "RNAP", + "RNAP" + ] + }, + { + "id": "8040", + "type": "gene", + "text": "CONCLUSIONS : Our meta - analysis of randomized controlled trials of HRT noted a statistically significant reduction in nonvertebral fractures .", + "entities": [] + }, + { + "id": "8041", + "type": "gene", + "text": "Analysis of mCTR mRNAs has revealed that the three alternative promoters give rise to at least seven mCTR isoforms in the 5 ' region of the gene and generate 5 ' - untranslated regions of very different lengths .", + "entities": [ + "mCTR mRNAs", + "mCTR isoforms" + ] + }, + { + "id": "8042", + "type": "gene", + "text": "An int6 deletion ( int6Delta ) mutant was viable but grew slowly in minimal medium .", + "entities": [ + "int6 deletion", + "int6Delta" + ] + }, + { + "id": "8043", + "type": "gene", + "text": "Pmt2 is a member of a six - protein family in yeast that catalyzes the first step in O mannosylation of target proteins .", + "entities": [ + "Pmt2" + ] + }, + { + "id": "8044", + "type": "gene", + "text": "There was a close correlation between plasma clearance of NT by 10 - hydroxylation and the D metabolic ratio ( D / 4 - OH - D in urine ) in the Ghanaians ( rs = - 0 . 95 ; P less than 0 . 01 ) and Swedes ( rs = - 0 . 84 ; P less than 0 . 01 ) .", + "entities": [] + }, + { + "id": "8045", + "type": "gene", + "text": "A high mean intensity of CLTPA ( standardized multivariate regression coefficient beta - 0 . 059 , p = 0 . 020 ) and a high maximal oxygen uptake ( beta - 0 . 163 , p < 0 . 001 ) were associated with reduced plasma fibrinogen when adjusting for the strongest covariates .", + "entities": [ + "plasma fibrinogen" + ] + }, + { + "id": "8046", + "type": "gene", + "text": "The deduced 96 - residue amino acid coding sequence of the murine HMG - I ( Y ) cDNA is very similar to the reported amino acid sequence of human HMG - I , except that it lacks 11 internal amino acids reported in the human protein .", + "entities": [ + "HMG - I ( Y )", + "HMG - I" + ] + }, + { + "id": "8047", + "type": "gene", + "text": "Disorders of platelet function in chronic myeloid leukemias", + "entities": [] + }, + { + "id": "8048", + "type": "gene", + "text": "To derive quantitative concentration changes from measurements of light attenuation , the optical path length must be known .", + "entities": [] + }, + { + "id": "8049", + "type": "gene", + "text": "Double - staining confirmed that there were separate populations of CD68 - positive macrophages and XIIIa - positive dendrocytes .", + "entities": [ + "CD68", + "XIIIa" + ] + }, + { + "id": "8050", + "type": "gene", + "text": "These findings suggest that both in the early stages ( 0T , 0N ) and in more severe stages of VWF ( stages 1 - 2 ) cold induced hyperreactivity in the digital vessels and Raynaud ' s syndrome are vascular disorders of functional origin occurring without any prethrombotic alterations .", + "entities": [] + }, + { + "id": "8051", + "type": "gene", + "text": "The activation and injury of endothelial cells induced by TNF and other proinflammatory cytokines may underlie the local effects of these mediators in vivo .", + "entities": [ + "TNF" + ] + }, + { + "id": "8052", + "type": "gene", + "text": "The alpha inhibin promoter containing a mutated CRE was not regulated by forskolin in granulosa cells and did not bind the CREB protein .", + "entities": [ + "alpha inhibin promoter", + "CREB protein" + ] + }, + { + "id": "8053", + "type": "gene", + "text": "However , overexpression of both the STE4 and STE18 proteins did not generate a stronger pheromone response than overexpression of STE4 in the presence of wild - type levels of STE18 .", + "entities": [ + "STE4", + "STE18 proteins", + "STE4", + "STE18" + ] + }, + { + "id": "8054", + "type": "gene", + "text": "S1 nuclease analysis of RNA prepared after transfection of these HIV constructs into HeLa cells infected with wild - type adenovirus indicated that the enhancer , SP1 , TATA , and a portion of the transactivation - responsive element were each required for complete E1A / E1B - mediated activation of the HIV LTR .", + "entities": [ + "S1 nuclease", + "SP1", + "E1A", + "E1B", + "HIV LTR" + ] + }, + { + "id": "8055", + "type": "gene", + "text": "Transcripts for both ODV - E18 and ODV - EC27 initiate from conserved TAAG motifs , and transcripts are detected from 16 through 72 hr p . i .", + "entities": [ + "ODV - E18", + "ODV - EC27" + ] + }, + { + "id": "8056", + "type": "gene", + "text": "In DNA strand exchange reactions using oligonucleotides , we found that Rec2 exhibited a pairing bias that is opposite that of RecA .", + "entities": [ + "Rec2", + "RecA" + ] + }, + { + "id": "8057", + "type": "gene", + "text": "During BH the ventilator was disconnected and a bias flow of 50 % O2 at 4 - 5 l / min was delivered through the side ports of a small catheter whose tip was positioned 1 cm cephalad of the carina .", + "entities": [] + }, + { + "id": "8058", + "type": "gene", + "text": "In cells limited for His , increased expression of arg - 2 and cpc - 1 , and decreased expression of cox - 5 , also had translational and transcriptional components .", + "entities": [ + "arg - 2", + "cpc - 1", + "cox - 5" + ] + }, + { + "id": "8059", + "type": "gene", + "text": "We speculate that the human papillomavirus late mRNAs , produced from several hundred copies of the virus genome present in infected cells , compete with the c - fos mRNAs for destabilizing cellular factors and that this may lead to elevated Fos protein levels in human papillomavirus infected cells .", + "entities": [ + "c - fos mRNAs", + "Fos protein" + ] + }, + { + "id": "8060", + "type": "gene", + "text": "The csbA fusion was maximally expressed during early stationary phase in cells grown in Luria broth containing 5 % glucose and 0 . 2 % glutamine .", + "entities": [ + "csbA fusion" + ] + }, + { + "id": "8061", + "type": "gene", + "text": "We conclude that CPET is a useful investigation in the management of patients with cardiopulmonary disease and complements the various other investigations offered by a pulmonary function laboratory .", + "entities": [] + }, + { + "id": "8062", + "type": "gene", + "text": "We have also found that the in vitro interaction between the SV40 octamer motif and the lymphoid cell - specific protein oct - B2 was negatively modulated by a component present in the nuclear extracts from several lymphoid cell lines .", + "entities": [ + "lymphoid cell - specific protein oct - B2" + ] + }, + { + "id": "8063", + "type": "gene", + "text": "The protein kinase domains of LIMK1 and LIMK2 are unique in that they contain an unusual sequence motif Asp - Leu - Asn - Ser - His - Asn in subdomain VIB and a highly basic insert between subdomains VII and VIII .", + "entities": [ + "LIMK1", + "LIMK2" + ] + }, + { + "id": "8064", + "type": "gene", + "text": "The diagnosis of metachromatic leukodystrophy ( MLD ) was confirmed by the finding of low arylsulfatase A ( ASA ) levels in cultured fibroblasts in both sisters .", + "entities": [ + "arylsulfatase A", + "ASA" + ] + }, + { + "id": "8065", + "type": "gene", + "text": "This interaction involved the SH3 region of p50 ( csk ) and a proline - rich region ( PPPLPERTPESFVLADM ) outside the catalytic region of PTP - PEST .", + "entities": [ + "SH3 region", + "p50", + "csk", + "PTP" + ] + }, + { + "id": "8066", + "type": "gene", + "text": "IFN - stimulated gene factor - 3 and STAT1 homodimers formed and bound an IFN - stimulated response element ( ISRE ) and gamma - activated sequence ( GAS ) element , respectively .", + "entities": [ + "IFN - stimulated gene factor - 3", + "STAT1 homodimers", + "IFN - stimulated response element", + "ISRE", + "gamma - activated sequence", + "GAS" + ] + }, + { + "id": "8067", + "type": "gene", + "text": "Multidrug resistance in Saccharomyces cerevisiae mainly results from the overexpression of genes coding for the membrane efflux pumps , the major facilitators and the ABC binding cassette transporters , under the control of key transcription regulators encoded by the PDR1 and PDR3 genes .", + "entities": [ + "ABC binding cassette transporters", + "PDR1", + "PDR3 genes" + ] + }, + { + "id": "8068", + "type": "gene", + "text": "Immunogenicity of various mycobacteria and the corresponding levels of cross - protection developed between species .", + "entities": [] + }, + { + "id": "8069", + "type": "gene", + "text": "The exogenous fos gene was rapidly induced to maximal levels within 1 - 2 hr of estrogen addition .", + "entities": [ + "fos gene" + ] + }, + { + "id": "8070", + "type": "gene", + "text": "The importin alpha . beta heterodimer mediates nuclear import of proteins containing classical nuclear localization signals .", + "entities": [ + "importin alpha . beta heterodimer" + ] + }, + { + "id": "8071", + "type": "gene", + "text": "A reduced matrix distribution and enhanced cell density were observed as the biofilm aged .", + "entities": [] + }, + { + "id": "8072", + "type": "gene", + "text": "The Myc LZ was found to prevent homodimeric interactions , thus explaining Myc inability to homodimerize efficiently .", + "entities": [ + "Myc LZ", + "Myc" + ] + }, + { + "id": "8073", + "type": "gene", + "text": "However , division of the chest wall muscles , usually with diathermy , contributes to prolonged pain and morbidity .", + "entities": [] + }, + { + "id": "8074", + "type": "gene", + "text": "Results from in vitro transcription - translation analysis and maxicell experiments suggested that the 447 - bp ORF was the one being actively expressed .", + "entities": [] + }, + { + "id": "8075", + "type": "gene", + "text": "DNA sequence analysis showed that the gene was 525 bp long and encoded a 175 - amino - acid protein with a molecular weight of 19 , 094 containing a 21 - residue typical lipoprotein signal peptide and consensus prolipoprotein processing site .", + "entities": [] + }, + { + "id": "8076", + "type": "gene", + "text": "According to the results of assays obtained with the use of assay systems ORTHO ELISA and ABBOTT HCV EIA ( USA ) , the detection rate of anti - HCV - C100 - 3 among primary blood donors in Moscow was 1 . 37 % and was not different from that among HBsAg carriers ( 1 . 8 % ) and among donors with anti - HCV - C100 - 3 in the blood ( 1 . 6 % ) ( p < 0 . 01 ) .", + "entities": [ + "anti - HCV - C100 - 3", + "HBsAg", + "anti - HCV - C100 - 3" + ] + }, + { + "id": "8077", + "type": "gene", + "text": "For this purpose , the writhing test , capsaicin and formalin induced - pain in mice were used .", + "entities": [] + }, + { + "id": "8078", + "type": "gene", + "text": "Standardized gastric wall specimens from the area of grossly healed ulcers were obtained , processed , and evaluated by light microscopy and by transmission electron microscopy .", + "entities": [] + }, + { + "id": "8079", + "type": "gene", + "text": "The GT - foreign - pictures showed that the judgment of other subjects changed toward hedonic and permeability directions .", + "entities": [] + }, + { + "id": "8080", + "type": "gene", + "text": "Myelomatous pleural effusion as presentation form of multiple myeloma", + "entities": [] + }, + { + "id": "8081", + "type": "gene", + "text": "Examination of the sequence of the Punta Toro M gene product reveals the presence of multiple hydrophobic sequences including a 19 - amino acid , carboxy - proximal , hydrophobic region ( G2 ) .", + "entities": [ + "Punta Toro M gene product" + ] + }, + { + "id": "8082", + "type": "gene", + "text": "In addition to the significant reduction in blood pressure , the angiotensin converting enzyme ( ACE ) inhibitor ramipril caused a significant regression of pathologic left ventricular hypertrophy demonstrated by magnetic resonance imaging and echocardiography .", + "entities": [ + "angiotensin converting enzyme", + "ACE" + ] + }, + { + "id": "8083", + "type": "gene", + "text": "Although linker regions in transcription factors are known to modulate DNA binding specificity , our studies suggest that the human HSF1 linker plays no role in determining HSF1 binding preferences in vivo but is a critical determinant in regulating the HSF1 monomer - trimer equilibrium .", + "entities": [ + "human HSF1", + "HSF1", + "HSF1 monomer - trimer" + ] + }, + { + "id": "8084", + "type": "gene", + "text": "Multiple regression analysis performed between these long - term abiotic factors and nymphal abundance in positive sites showed high relationship ( R2 coefficients ) for every habitat category and explained > 50 % of the variation in tick abundance .", + "entities": [] + }, + { + "id": "8085", + "type": "gene", + "text": "Twenty - nine days after injection of 5 . 8 mCi of Tc - 99m , which gives 28 rads to the testis , the number of sperm hads decreased to 70 % of control .", + "entities": [] + }, + { + "id": "8086", + "type": "gene", + "text": "The unilateral vestibular hypofunction .", + "entities": [] + }, + { + "id": "8087", + "type": "gene", + "text": "A new physiopathological treatment of HBV - related polyarteritis inspired by advances in the treatment of chronic active hepatitis B was tested in 7 patients .", + "entities": [] + }, + { + "id": "8088", + "type": "gene", + "text": "Most yeast peroxisomal matrix proteins contain a type 1C - terminal peroxisomal targeting signal ( PTS1 ) consisting of the tripeptide SKL or a conservative variant thereof .", + "entities": [ + "yeast peroxisomal matrix proteins" + ] + }, + { + "id": "8089", + "type": "gene", + "text": "Moxidectin ( at 3 times the therapeutic dose ) did not have deleterious effects on cow reproductive performance as examined ( eg , at folliculogenesis , ovulation , and the early embryonic phase of development ) .", + "entities": [] + }, + { + "id": "8090", + "type": "gene", + "text": "We conclude that , in AIDS patients with cryptococcosis , tolerance to ILd - AmB was acceptable when the daily dosage did not exceed 1 mg / kg , but the higher 1 . 5 mg / kg daily dosage was associated with an unacceptable rate of nephrotoxicity .", + "entities": [] + }, + { + "id": "8091", + "type": "gene", + "text": "The frequency of integrations that led to transcription of the lacZ gene was estimated to be 0 . 5 % of all integrations , of which 14 % were downregulated on differentiation of 32D cells towards neutrophils .", + "entities": [ + "lacZ gene" + ] + }, + { + "id": "8092", + "type": "gene", + "text": "We report the use of a new technetium - 99m - albumin colloid white blood cell ( TAC - WBC ) scan in the evaluation of appendicitis .", + "entities": [ + "albumin" + ] + }, + { + "id": "8093", + "type": "gene", + "text": "Dietary supplement with fish oil and related n - 3 EFAs has been used to study their antihypertensive property in animals and humans with borderline and essential hypertension .", + "entities": [] + }, + { + "id": "8094", + "type": "gene", + "text": "The comparisons revealed that female homicide - suicide perpetrators were more likely than female homicide - suicide victims to live in mobile homes , kill their lover or ex - lover , have their crime accidentally discovered , leave a suicide note , kill on a weekend , and be depressed , but are less likely than female homicide - suicide victims to live with a spouse .", + "entities": [] + }, + { + "id": "8095", + "type": "gene", + "text": "This study reports the isolation of a P . hybrida gene , jaf13 , encoding a basic helix - loop - helix protein that , on the basis of sequence homology and intron / exon structure , represents the P . hybrida orthologue of the Z . mays r genes .", + "entities": [ + "jaf13", + "basic helix - loop - helix protein", + "Z . mays r genes" + ] + }, + { + "id": "8096", + "type": "gene", + "text": "[ Clinical and epidemiological characteristics of squamous cell carcinoma of the oral cavity in women ] BACKGROUND : Squamous cell carcinoma ( SCC ) of the oral cavity occurs mainly in the male population .", + "entities": [] + }, + { + "id": "8097", + "type": "gene", + "text": "5 - ( Dimethylaminopropyl ) - 19 , 11 - dihydro - 5H - benzo [ 2 , 3 ] pyrido [ 6 , 7 - b ] azepine .", + "entities": [] + }, + { + "id": "8098", + "type": "gene", + "text": "According to their functional properties the latter neurons were subdivided into : ( a ) neurons responding to stimuli near the eyes ; ( b ) neurons triggered by complex visual stimuli ; ( c ) neurons inhibited by visual stimuli .", + "entities": [] + }, + { + "id": "8099", + "type": "gene", + "text": "To determine the function of VZV gK in virus growth , a series of gK deletion mutants were constructed with VZV cosmid DNA derived from the Oka strain .", + "entities": [ + "VZV gK", + "gK deletion mutants" + ] + }, + { + "id": "8100", + "type": "gene", + "text": "Contributions from pairs of source and target volume elements are summed for the S values between the tumor and itself , between the remaining healthy host organ and itself , and between the tumor and the remaining healthy host organ , with the reciprocity theorem assumed for the last .", + "entities": [] + }, + { + "id": "8101", + "type": "gene", + "text": "This protein is present in both HeLa nuclear extracts and S100 extracts but absent from SR protein preparations , suggesting that it is not a classical SR protein .", + "entities": [ + "S100", + "SR protein", + "SR protein" + ] + }, + { + "id": "8102", + "type": "gene", + "text": "The transcript was initially identified as a partial cDNA sequence in the course of constructing a transcript map of the region between markers D11S1765 and uteroglobin known to encompass the gene causing Best disease .", + "entities": [ + "D11S1765", + "uteroglobin" + ] + }, + { + "id": "8103", + "type": "gene", + "text": "The 26S rRNA binding ribosomal protein equivalent to bacterial protein L11 is encoded by unspliced duplicated genes in Saccharomyces cerevisiae .", + "entities": [ + "26S rRNA binding ribosomal protein", + "bacterial protein L11" + ] + }, + { + "id": "8104", + "type": "gene", + "text": "We conclude that administration of the calcium antagonist Verapamil is of no additional value in tocolytic treatment with beta - mimetics .", + "entities": [] + }, + { + "id": "8105", + "type": "gene", + "text": "It encodes a protein with three zinc fingers similar to those of the transcription factor Sp1 .", + "entities": [ + "transcription factor Sp1" + ] + }, + { + "id": "8106", + "type": "gene", + "text": "In vitro transcription assays demonstrate that the TCA - cycle intermediate , fumarate , directly and specifically inhibits the formation of the clcA transcript .", + "entities": [ + "clcA transcript" + ] + }, + { + "id": "8107", + "type": "gene", + "text": "Addition of synthetic tyrosine - phosphorylated peptides derived from betac cytoplasmic tyrosines prior to GM - CSF stimulation inhibited the in vitro activation of STAT5 .", + "entities": [ + "GM - CSF", + "STAT5" + ] + }, + { + "id": "8108", + "type": "gene", + "text": "METHODS : We determined an odds ratio ( OR ) , as a measure of the relative risk of being exposed to a potential interaction , comparing the use of the H2 - receptor antagonist , cimetidine , with that of the noninteracting agents ranitidine , famotidine and nizatidine in users and nonusers of warfarin , phenytoin and theophylline .", + "entities": [ + "H2 - receptor" + ] + }, + { + "id": "8109", + "type": "gene", + "text": "However these search engines respond with such cumbersome results that domain specific experts can not tolerate .", + "entities": [] + }, + { + "id": "8110", + "type": "gene", + "text": "Expression of herpes simplex virus type 2 US3 affects the Cdc42 / Rac pathway and attenuates c - Jun N - terminal kinase activation .", + "entities": [ + "herpes simplex virus type 2 US3", + "Cdc42", + "Rac", + "c - Jun N - terminal kinase" + ] + }, + { + "id": "8111", + "type": "gene", + "text": "Pathol .", + "entities": [] + }, + { + "id": "8112", + "type": "gene", + "text": "Results support the hypothesis that endogenous corticotropin - releasing factor , perhaps acting at a peripheral binding site , suppresses the active behavioral response characteristic of pups during the early phase of isolation in novel surroundings .", + "entities": [ + "endogenous corticotropin - releasing factor" + ] + }, + { + "id": "8113", + "type": "gene", + "text": "Localization of the intronless gene coding for calmodulin - like protein CLP to human chromosome 10p13 - ter .", + "entities": [ + "CLP" + ] + }, + { + "id": "8114", + "type": "gene", + "text": "A local , high - density , single - nucleotide polymorphism map used to clone Caenorhabditis elegans cdf - 1 .", + "entities": [ + "Caenorhabditis elegans cdf - 1" + ] + }, + { + "id": "8115", + "type": "gene", + "text": "EGV had no detectable effect on PP secretion under basal or stimulated conditions .", + "entities": [ + "PP" + ] + }, + { + "id": "8116", + "type": "gene", + "text": "Late mRNA selected by a cDNA homologous to the HindIII - P / EcoRI - B region of the AcNPV map directed the synthesis of 31K and 30K proteins which comigrated with the 31K and 30K proteins translated from RNA selected by the HindIII - A / EcoRI - C / SstI - G cDNA .", + "entities": [ + "HindIII - P", + "EcoRI - B", + "HindIII - A", + "EcoRI - C", + "SstI - G" + ] + }, + { + "id": "8117", + "type": "gene", + "text": "The COP - PAWP gradient was markedly decreased in both shock and non - shock patients with pulmonary edema .", + "entities": [] + }, + { + "id": "8118", + "type": "gene", + "text": "Based on our observations , we propose a model whereby inactive precursor molecules produced from the PEP4 gene self - activate within the yeast vacuole and subsequently activate other vacuolar hydrolases .", + "entities": [ + "PEP4 gene", + "vacuolar hydrolases" + ] + }, + { + "id": "8119", + "type": "gene", + "text": "No significant correlation was found between LVM or wall thickness and body surface area , age , blood pressure , heart rate , cardiac output , total peripheral resistance and left ventricular systolic wall stress , whereas CD25 was correlated with urinary catecholamines only in hypertensive patients ( r = 0 . 606 , p less than 0 . 001 ) .", + "entities": [] + }, + { + "id": "8120", + "type": "gene", + "text": "Although human infections with bacteraemia due to Pasteurella multocida are not uncommon , endocarditis associated with P . haemolytica is rare .", + "entities": [] + }, + { + "id": "8121", + "type": "gene", + "text": "Cytoplasmic dynein is a multisubunit , microtubule - dependent mechanochemical enzyme that has been proposed to function in a variety of intracellular movements , including minus - end - directed transport of organelles .", + "entities": [ + "Cytoplasmic dynein" + ] + }, + { + "id": "8122", + "type": "gene", + "text": "Despite its requirement for enhancer - dependent splicing activity in vitro , the dU2AF38 RS domain was also inessential in vivo .", + "entities": [ + "dU2AF38 RS domain" + ] + }, + { + "id": "8123", + "type": "gene", + "text": "This repression was reversed agonists of either receptor demonstrating a functional interaction between NCoR and PPARalpha . RXRalpha heterodimeric complexes in mammalian cells .", + "entities": [ + "NCoR", + "PPARalpha", + "RXRalpha" + ] + }, + { + "id": "8124", + "type": "gene", + "text": "16 percent , P < 0 . 001 ) , and sustained normalization of serum alanine aminotransferase levels ( 41 percent vs .", + "entities": [ + "serum alanine aminotransferase" + ] + }, + { + "id": "8125", + "type": "gene", + "text": "A simplified thin - layer chromatographic determination of hippuric acid and methylhippuric acids .", + "entities": [] + }, + { + "id": "8126", + "type": "gene", + "text": "Modern studies , conducted with Delta - 9 - THC , in healthy voluntaries , again suggest the comparison or even the identity of the modifications caused by cannabis with sleep and dream .", + "entities": [] + }, + { + "id": "8127", + "type": "gene", + "text": "Characterization of the promoter for the human 85 kDa cytosolic phospholipase A2 gene .", + "entities": [ + "human 85 kDa cytosolic phospholipase A2 gene" + ] + }, + { + "id": "8128", + "type": "gene", + "text": "We further studied the effects of SIE - 1 hypermethylation on p21WAF1 induction by STAT activation .", + "entities": [ + "SIE - 1", + "p21WAF1", + "STAT" + ] + }, + { + "id": "8129", + "type": "gene", + "text": "RNA polymerase II inhibition increased the binding of ARE ( AUBP activity ) and poly ( U ) - Sepharose by cytoplasmic hnRNP A1 , while nuclear hnRNP A1 binding was unaffected .", + "entities": [ + "RNA polymerase II", + "cytoplasmic hnRNP A1", + "nuclear hnRNP A1" + ] + }, + { + "id": "8130", + "type": "gene", + "text": "A 38 - bp poly ( dA - dT ) region was found to be a positive regulator of Act1 promoter activity .", + "entities": [ + "Act1 promoter" + ] + }, + { + "id": "8131", + "type": "gene", + "text": "The results support earlier reports that collagenase inhibitors are useful in controlling blister formation in recessive dystrophic epidermolysis bullosa .", + "entities": [ + "collagenase" + ] + }, + { + "id": "8132", + "type": "gene", + "text": "RESULTS : Total IgE levels showed a tendency to diminish .", + "entities": [ + "IgE" + ] + }, + { + "id": "8133", + "type": "gene", + "text": "The concentrations of plasma ACTH and cortisol increased by 40 % and 60 % after MPTP treatment , respectively .", + "entities": [ + "ACTH" + ] + }, + { + "id": "8134", + "type": "gene", + "text": "The role of calcitonin , and other agonists which activate the cAMP pathway , in regulating transcription of the human parathyroid hormone - related protein ( PTHrP ) gene was investigated in a human lung cancer cell line ( BEN ) .", + "entities": [ + "calcitonin", + "human parathyroid hormone - related protein", + "PTHrP" + ] + }, + { + "id": "8135", + "type": "gene", + "text": "67 393 bp of contiguous DNA located between markers cdc18 and cdc14 on the right arm of fission yeast chromosome II has been sequenced as part of the European Union Schizosaccharomyces pombe genome sequencing project .", + "entities": [ + "cdc18", + "cdc14" + ] + }, + { + "id": "8136", + "type": "gene", + "text": "Resistance to thyroid hormone : implications for neurodevelopmental research on the effects of thyroid hormone disruptors .", + "entities": [] + }, + { + "id": "8137", + "type": "gene", + "text": "Substitutions introduced at bases surrounding the ICR2 motif yielded levels of pRNA replication that differed , depending on the maintenance of a putative 5 ' stem - loop structure in the positive strand of the viral genome .", + "entities": [ + "ICR2 motif" + ] + }, + { + "id": "8138", + "type": "gene", + "text": "Individuals attending the GUM Department in the Royal Infirmary of Edinburgh between 1990 and 1994 with the diagnosis of HIV infection , genital warts , genital herpes , non - specific genital infection ( NSGI ) , gonorrhoea and syphilis were included in the study .", + "entities": [] + }, + { + "id": "8139", + "type": "gene", + "text": "Prominent findings were chronic pancreatitis with acinar and ductal plugs , granulomatous and necrotizing peripancreatic steatitis , degenerative myopathy , testicular atrophy , candidiasis and bacterial necrotizing glossitis .", + "entities": [] + }, + { + "id": "8140", + "type": "gene", + "text": "The most likely explanation for this is that gold principally accumulates in the Kupffer cells and renal cortex and these cells do not express Type I deiodinase .", + "entities": [ + "Type I deiodinase" + ] + }, + { + "id": "8141", + "type": "gene", + "text": "It has been previously shown that genes transcribed by RNA polymerase II ( RNAP II ) are subject to position effect variegation when located near yeast telomeres .", + "entities": [ + "RNA polymerase II", + "RNAP II" + ] + }, + { + "id": "8142", + "type": "gene", + "text": "RESULTS : In an 18 moth period and out of a total of 284 positive blood cultures ( 154 significant isolations ) 14 episodes of bacteremia by M . tuberculosis were studied in 12 prison patients coinfected by the human immunodeficiency virus with associated severe immunosuppression ( mean of CD4 = 0 . 068 x 10 ( 9 ) / l ) .", + "entities": [ + "CD4" + ] + }, + { + "id": "8143", + "type": "gene", + "text": "Such a mechanism may allow acceleration of degenerative joint conditions , and may account for the increased prevalence of such conditions seen with HMS subjects .", + "entities": [] + }, + { + "id": "8144", + "type": "gene", + "text": "Identification of a cis - acting element in the class I major histocompatibility complex gene promoter responsive to activation by retroviral sequences .", + "entities": [ + "class I major histocompatibility complex gene promoter" + ] + }, + { + "id": "8145", + "type": "gene", + "text": "In this report , we demonstrate that hGCN5 is also an HAT and has the same substrate specificity as yGCN5 .", + "entities": [ + "hGCN5", + "HAT", + "yGCN5" + ] + }, + { + "id": "8146", + "type": "gene", + "text": "A normal systemic response was obtained after IF , indicating that rhG - CSF retains activity in the solid state .", + "entities": [ + "rhG - CSF" + ] + }, + { + "id": "8147", + "type": "gene", + "text": "Among the H / ACA snoRNAs associated with Gar1p , one can distinguish a large group of snoRNAs that are not essential in yeast and serve as guides for pseudouridine synthesis onto the pre - rRNA molecule .", + "entities": [ + "H / ACA snoRNAs", + "Gar1p" + ] + }, + { + "id": "8148", + "type": "gene", + "text": "The decrease of TNF receptors by IL - 4 was accompanied by down - regulation of TNF - induced activities , including cytotoxicity , caspase - 3 activation , NF - kappaB and AP - 1 activation , and c - Jun N - terminal kinase induction .", + "entities": [ + "TNF receptors", + "IL - 4", + "TNF", + "caspase - 3", + "NF - kappaB", + "AP - 1", + "c - Jun N - terminal kinase" + ] + }, + { + "id": "8149", + "type": "gene", + "text": "Overall agreement between rest / postnitroglycerin technetium - 99m tetrofosmin SPET studies and rest / redistribution or rest / reinjection thallium - 201 SPET studies , regarding the presence of myocardial viability , was 87 % and 90 % , respectively .", + "entities": [] + }, + { + "id": "8150", + "type": "gene", + "text": "These data show that the spv virulence genes belong simultaneously to several regulons in the cell , raising the possibility that spv expression can be fine - tuned in response to multiple environmental inputs .", + "entities": [ + "spv virulence genes", + "spv" + ] + }, + { + "id": "8151", + "type": "gene", + "text": "These data indicate that activation of these enzymes is not sufficient for the acute stimulation of glucose transport .", + "entities": [] + }, + { + "id": "8152", + "type": "gene", + "text": "The infected cell protein no . 0 ( ICP0 ) of herpes simplex virus 1 is a promiscuous transactivator shown to enhance the expression of genes introducted into cells by infection or transfection .", + "entities": [ + "infected cell protein no . 0", + "ICP0" + ] + }, + { + "id": "8153", + "type": "gene", + "text": "Herein , we show that Smad3 physically interacts with the HMG box domain of LEF1 and that TGFbeta and Wnt pathways synergize to activate transcription of the Xenopus homeobox gene twin ( Xtwn ) .", + "entities": [ + "Smad3", + "HMG", + "LEF1", + "TGFbeta", + "Wnt", + "twin", + "Xtwn" + ] + }, + { + "id": "8154", + "type": "gene", + "text": "Our results indicate that the binding of CBF / NF - Y to the inverted CCAAT box is responsible for transcriptional activation of the nTPH gene .", + "entities": [ + "CBF", + "NF - Y", + "nTPH gene" + ] + }, + { + "id": "8155", + "type": "gene", + "text": "These results demonstrate that dopamine receptor stimulation by different dopamine agonists produces a different pattern of effects on the characteristics of the reaction time response .", + "entities": [ + "dopamine receptor" + ] + }, + { + "id": "8156", + "type": "gene", + "text": "In contrast to some results previously published for a very close sequence variant ( see ref .", + "entities": [] + }, + { + "id": "8157", + "type": "gene", + "text": "Thus analysis indicated no reliable evidence that conscious presleep suggestions become incorporated into dream content .", + "entities": [] + }, + { + "id": "8158", + "type": "gene", + "text": "Collaborative study of Japanese Pharmacopoeia Heparin Sodium Reference Standard", + "entities": [] + }, + { + "id": "8159", + "type": "gene", + "text": "Topoisomerase II is a major target of the protein kinase casein kinase 2 ( PK CK2 ) in vivo .", + "entities": [ + "Topoisomerase II", + "protein kinase casein kinase 2", + "PK CK2" + ] + }, + { + "id": "8160", + "type": "gene", + "text": "EMBO J .", + "entities": [] + }, + { + "id": "8161", + "type": "gene", + "text": "One hundred fifty patients were reviewed at 1 year after arthroplasty .", + "entities": [] + }, + { + "id": "8162", + "type": "gene", + "text": "When given the choice between an estrous female and a sexually active male in the AOF , flutamide females , as well as controls , preferred the male partner .", + "entities": [] + }, + { + "id": "8163", + "type": "gene", + "text": "Studies of lipoprotein - X ( LP - X ) and bile acids in familial LCAT deficiency .", + "entities": [ + "lipoprotein - X", + "LP - X", + "LCAT" + ] + }, + { + "id": "8164", + "type": "gene", + "text": "To further understand the role of cis - acting elements in these regulatory mechanisms , we have characterized a transcriptional promoter that drives germline expression of TCR beta gene segments in vivo .", + "entities": [ + "TCR beta gene segments" + ] + }, + { + "id": "8165", + "type": "gene", + "text": "CONCLUSION : MMF ( 2 - 3 g / day ) is unable to control the signs of mucocutaneous Adamantiades - Behcet ' s disease .", + "entities": [] + }, + { + "id": "8166", + "type": "gene", + "text": "Immunoprecipitation experiments using DokR - specific antibodies revealed an interaction between endogenous DokR and a 150 - kDa protein that is tyrosine - phosphorylated in EGF - stimulated BaF / 3 cells .", + "entities": [ + "DokR - specific antibodies", + "endogenous DokR", + "EGF" + ] + }, + { + "id": "8167", + "type": "gene", + "text": "A retrospective epidemiological study is reported concerning burn injuries in 775 children hospitalized at the unit of burn care of Casablanca between 1985 and 1993 .", + "entities": [] + }, + { + "id": "8168", + "type": "gene", + "text": "Interestingly , dTFIIA - L / S is also able to significantly enhance transcriptional activation by upstream transcription factors including Sp1 , VP16 , and NTF - 1 .", + "entities": [ + "dTFIIA - L / S", + "Sp1", + "VP16", + "NTF - 1" + ] + }, + { + "id": "8169", + "type": "gene", + "text": "The computer - programmed cytocentrifuge is currently most popular .", + "entities": [] + }, + { + "id": "8170", + "type": "gene", + "text": "The effects of cardioselective beta - 1 adrenergic agonist , 1 - ( 4 - hydroxyphenoxy ) - isopropylamino - 2 - propanol ) , i . e . , prenalterol , were examined on direct and continuous measurements of left ventricular ( LV ) pressure , diameter , dP / dt , velocity of shortening , arterial pressure , iliac blood flow and heart rate in 10 conscious dogs .", + "entities": [] + }, + { + "id": "8171", + "type": "gene", + "text": "Analysis of homologous DNA sequences within the first intron of the mouse and human mts1 genes : kB - like site and microsatellite DNA", + "entities": [ + "mouse and human mts1 genes", + "kB - like site" + ] + }, + { + "id": "8172", + "type": "gene", + "text": "When the l - methadone - sensitive , opioid receptor is blocked by naloxone or tolerance has developed , than l - methadone can produce behavioral effects by a nonopioid mechanism .", + "entities": [ + "opioid receptor" + ] + }, + { + "id": "8173", + "type": "gene", + "text": "Filter and cytocentrifuge preparations of the urine were studied and all cases displayed numerous scattered aggregates or single tumor cells in an inflammatory background .", + "entities": [] + }, + { + "id": "8174", + "type": "gene", + "text": "Only one of these bands was supershifted by antibody to p50 , whereas antibodies to p65 or other NF - kappaB proteins had no effect .", + "entities": [ + "p50", + "p65", + "NF - kappaB proteins" + ] + }, + { + "id": "8175", + "type": "gene", + "text": "Temporal control of GUS expression was found to involve two negative regulatory sequences , NRS1 ( - 391 to - 295 ) and NRS2 ( - 518 to - 418 ) , as well as the positive domain UAS1 .", + "entities": [ + "GUS" + ] + }, + { + "id": "8176", + "type": "gene", + "text": "Partial characterization of the active site human platelet cAMP phosphodiesterase , PDE3A , by site - directed mutagenesis .", + "entities": [ + "human platelet cAMP phosphodiesterase", + "PDE3A" + ] + }, + { + "id": "8177", + "type": "gene", + "text": "In this report , we focus on the genetics of the region of the 17 hep syn gB gene that conferred both the syncytial and pathogenic phenotypes to 17 syn + .", + "entities": [ + "17 hep syn gB gene", + "17 syn +" + ] + }, + { + "id": "8178", + "type": "gene", + "text": "These latter results showed that the ABFI protein , like the RAP1 protein , bound sequences required for positive as well as negative regulation of gene expression .", + "entities": [ + "ABFI protein", + "RAP1 protein" + ] + }, + { + "id": "8179", + "type": "gene", + "text": "The MABP and MCBFV signals were bandpass filtered in the very low - frequency range ( VLF , 0 . 015 - 0 . 07 Hz ) , low - frequency range ( LF , 0 . 07 - 0 . 15 Hz ) and high - frequency range ( HF , 0 . 15 - 0 . 40 Hz ) before applying CCF for the purpose of studying the effect of different bandwidths on the resulting mean CCFs .", + "entities": [] + }, + { + "id": "8180", + "type": "gene", + "text": "Thus , the characterization of the promoter region should help to define regulatory elements that control neuron - specific and developmental expression of the MAP1B gene .", + "entities": [ + "MAP1B gene" + ] + }, + { + "id": "8181", + "type": "gene", + "text": "Strikingly , stoichiometric association of p107 or p130 with either cyclin E - cdk2 or cyclin A - cdk2 negated the activities of these kinases .", + "entities": [ + "p107", + "p130", + "cyclin E", + "cdk2", + "cyclin A", + "cdk2" + ] + }, + { + "id": "8182", + "type": "gene", + "text": "However , the presence of Tax I increased the extent and altered the profile of proteins binding TRE - 2 in vivo .", + "entities": [ + "Tax I", + "TRE - 2" + ] + }, + { + "id": "8183", + "type": "gene", + "text": "In Schizosaccharomyces pombe , the activity of the M - phase - inducing Cdc2 / Cdc13 cyclin - dependent kinase is inhibited by Wee1 and Mik1 tyrosine kinases , and activated by Cdc25 and Pyp3 tyrosine phosphatases .", + "entities": [ + "Cdc2", + "Cdc13", + "Wee1", + "tyrosine kinases", + "Cdc25", + "tyrosine phosphatases" + ] + }, + { + "id": "8184", + "type": "gene", + "text": "Vestibular adaptation exercises and recovery : acute stage after acoustic neuroma resection .", + "entities": [] + }, + { + "id": "8185", + "type": "gene", + "text": "The histologic grade for the same anatomic site varied among hearts and among different anatomic sites in the same heart .", + "entities": [] + }, + { + "id": "8186", + "type": "gene", + "text": "We have identified amino acid sequences in mammalian and Xenopus NeuroD1 / BETA2 that are necessary for insulin gene expression and ectopic neurogenesis .", + "entities": [ + "NeuroD1", + "BETA2", + "insulin gene" + ] + }, + { + "id": "8187", + "type": "gene", + "text": "Orientation of the nuclear spin system by optical pumping causes an Overhauser shift of the excitonic energy levels proportional to the degree of nuclear orientation .", + "entities": [] + }, + { + "id": "8188", + "type": "gene", + "text": "Corticosteroid - mediated transcriptional inhibition was greater for MR / GR in combination than for MR or GR alone .", + "entities": [ + "MR", + "GR", + "MR", + "GR" + ] + }, + { + "id": "8189", + "type": "gene", + "text": "Hepatitis A infected food handler at an Edmonton , Alberta retail food facility : public health protection strategies .", + "entities": [] + }, + { + "id": "8190", + "type": "gene", + "text": "In this study we have investigated the role of C / EBP beta in initiating the adipogenic program by overexpressing C / EBP beta in multipotential NIH - 3T3 fibroblasts .", + "entities": [ + "C / EBP beta", + "C / EBP beta" + ] + }, + { + "id": "8191", + "type": "gene", + "text": "Fasting plasma and lipoprotein lipid concentrations , adipose tissue lipoprotein lipase activity , anthropometric data , alcohol consumption , smoking habits , weekly mileage run and performance on a bicycle ergometer were recorded before and after the training period .", + "entities": [ + "adipose tissue lipoprotein lipase" + ] + }, + { + "id": "8192", + "type": "gene", + "text": "Intravenous administration ( 25 mg / kg ) of carbonic anhydrase inhibitors ( acetazolamide , methazolamide , dichlorphenamide , sulthiame ) induced an early important rise of cortical p O2 , which is not dependent on increase of p O2 and p CO2 and decrease of pH in arterial blood .", + "entities": [ + "carbonic anhydrase" + ] + }, + { + "id": "8193", + "type": "gene", + "text": "Although stone - formers were not found to display any features of magnesium metabolism that were different from those in the control group , their lower urinary excretion of magnesium in relation to calcium may be a factor in their increased stone - forming propensity .", + "entities": [] + }, + { + "id": "8194", + "type": "gene", + "text": "The baroreflex latency ( from the ECG R - wave to the integrated MSNA burst peak ) was constant at approximately 1 . 20 s during sleep , suggesting that pulse - synchronicity was maintained .", + "entities": [] + }, + { + "id": "8195", + "type": "gene", + "text": "The duration and the amplitude of the negative potential were greatest for completely regenerating ears with overgrowth , smaller for partially regenerating ears , and smallest for the nonregenerating ears .", + "entities": [] + }, + { + "id": "8196", + "type": "gene", + "text": "Protein kinase C ( PKC ) , a widely - distributed enzyme implicated in the regulation of many physiological processes , consists of a family of at least twelve isoenzymes which differ in tissue distribution , subcellular localization , regulatory properties , etc .", + "entities": [ + "Protein kinase C", + "PKC" + ] + }, + { + "id": "8197", + "type": "gene", + "text": "Further investigation on the chemotactic influence of thymic hormone on lymphocytes", + "entities": [ + "thymic hormone" + ] + }, + { + "id": "8198", + "type": "gene", + "text": "Coliphage 186 B is a 72 - amino acid protein belonging to the Ogr family of analogous transcription factors present in P2 - like phage , which contain a Cys - X2 - Cys - X22 - Cys - X4 - Cys presumptive zinc - finger motif .", + "entities": [ + "Coliphage 186 B", + "Ogr" + ] + }, + { + "id": "8199", + "type": "gene", + "text": "The reduced rate of F absorption and slower rise in plasma F concentration accompanying delayed gastric emptying indicate that passage of F into the small intestine is the major factor in rapid F absorption .", + "entities": [] + }, + { + "id": "8200", + "type": "gene", + "text": "The juxtamembrane region of the insulin receptor ( IR ) beta - subunit contains an unphosphorylated tyrosyl residue ( Tyr960 ) that is essential for insulin - stimulated tyrosyl phosphorylation of some endogenous substrates and certain biological responses ( White , M . F . , Livingston , J . N . , Backer , J . M . , Lauris , V . , Dull , T . J . , Ullrich , A . , and Kahn , C . R .", + "entities": [ + "insulin receptor ( IR ) beta - subunit", + "insulin" + ] + }, + { + "id": "8201", + "type": "gene", + "text": "The products of the Saccharomyces cerevisiae CIN1 , CIN2 and CIN4 genes participate in a nonessential pathway required for normal microtubule function .", + "entities": [ + "Saccharomyces cerevisiae CIN1", + "CIN2", + "CIN4 genes" + ] + }, + { + "id": "8202", + "type": "gene", + "text": "Investigation of the structural basis of the interaction between human Igs and gp120 shows that the viral gp120 SAg can interact only with a subset of human V ( H ) 3 + Igs .", + "entities": [ + "human Igs", + "gp120", + "viral gp120 SAg", + "human V ( H ) 3 + Igs" + ] + }, + { + "id": "8203", + "type": "gene", + "text": "This failure to execute regulated G1 / S arrest is correlated with enhanced thermosensitivity of colony - forming ability .", + "entities": [] + }, + { + "id": "8204", + "type": "gene", + "text": "DESIGN : Comparison of number of women with PKU aged 15 - 44 years on the NSW PKU database ( observed number ) with expected number derived from population data .", + "entities": [] + }, + { + "id": "8205", + "type": "gene", + "text": "Northern blot and reverse transcription - PCR analyses of human mRNA samples demonstrate that RNR is expressed exclusively in the retina , with transcripts of approximately 7 . 5 kb , approximately 3 . 0 kb , and approximately 2 . 3 kb by Northern blot analysis .", + "entities": [ + "RNR" + ] + }, + { + "id": "8206", + "type": "gene", + "text": "Results of the long - term observation and treatment of patients with arterial hypertension", + "entities": [] + }, + { + "id": "8207", + "type": "gene", + "text": "62 : 2491 - 2499 , 1987 ) .", + "entities": [] + }, + { + "id": "8208", + "type": "gene", + "text": "The mechanism whereby zeta PKC regulates NF - kappa B most probably involves the activation of a putative I kappa B kinase of molecular mass approximately 50 kDa , which phosphorylates and inactivates I kappa B .", + "entities": [ + "zeta PKC", + "NF - kappa B", + "I kappa B kinase", + "I kappa B" + ] + }, + { + "id": "8209", + "type": "gene", + "text": "Serum gastrin levels did not change in either group ; however , background serum gastrin concentrations were significantly greater for V & P patients than V & A patients throughout the study .", + "entities": [ + "gastrin", + "gastrin" + ] + }, + { + "id": "8210", + "type": "gene", + "text": "KRN2391 and cromakalim produced a dose - dependent increase in aortic and coronary blood flow .", + "entities": [] + }, + { + "id": "8211", + "type": "gene", + "text": "Clinical differentiation of patients with mild diplegic cerebral palsy ( CP ) and idiopathic toe walking ( ITW ) can be difficult .", + "entities": [] + }, + { + "id": "8212", + "type": "gene", + "text": "An overexpression of the betaAPP gene in certain areas of the AD brain has been suggested to be an important factor in the neuropathology of AD .", + "entities": [ + "betaAPP gene" + ] + }, + { + "id": "8213", + "type": "gene", + "text": "The primary structure of each of the three proteins has about 70 % homology with that of mouse contrapsin , in contrast to 43 - 46 % homology with that of rat alpha 1 - protease inhibitor .", + "entities": [ + "mouse contrapsin", + "rat alpha 1 - protease" + ] + }, + { + "id": "8214", + "type": "gene", + "text": "Subacute diencephalic angioencephalopathy ( SDAE ) is a rare and fatal disease of unknown etiology that involves the thalami bilaterally .", + "entities": [] + }, + { + "id": "8215", + "type": "gene", + "text": "Consistent with this interpretation , a mutant form of XRN1 , which encodes a 5 ' - 3 ' exonuclease , was identified as an extragenic suppressor that increases the half - life of rhis4 mRNA , leading to a 10 - fold increase in steady - state mRNA levels compared to the wild - type HIS4 mRNA level .", + "entities": [ + "XRN1", + "rhis4 mRNA", + "wild - type HIS4 mRNA" + ] + }, + { + "id": "8216", + "type": "gene", + "text": "BYV , citrus tristeza virus ( CTV ) , beet yellow stunt virus ( BYSV ) and carnation necrotic fleck virus templates produced 1 kb amplification products , which were shown by sequencing to represent fragments of the respective HSP70 genes .", + "entities": [ + "HSP70 genes" + ] + }, + { + "id": "8217", + "type": "gene", + "text": "Further investigations are necessary to elucidate the biochemical and physiological properties of DLIS .", + "entities": [] + }, + { + "id": "8218", + "type": "gene", + "text": "These findings demonstrate that haemodialysis patients with chronic hepatitis C respond well to interferon treatment and that a long - term response is achieved in a high proportion of patients .", + "entities": [ + "interferon" + ] + }, + { + "id": "8219", + "type": "gene", + "text": "We found that total PSA can be detected in all cyst fluids and in about 75 % of female sera .", + "entities": [ + "PSA" + ] + }, + { + "id": "8220", + "type": "gene", + "text": "The investigation was thereafter continued in an open fashion by administering a single 10 mg dose of the MAO - B inhibitor deprenyl to the same subjects .", + "entities": [ + "MAO - B" + ] + }, + { + "id": "8221", + "type": "gene", + "text": "Paf1p may therefore be required for both positive and negative regulation of subsets of yeast genes .", + "entities": [ + "Paf1p" + ] + }, + { + "id": "8222", + "type": "gene", + "text": "BACKGROUND : Measurement of stereoacuity at varying distances , by real or simulated depth stereoacuity tests , is helpful in the evaluation of patients with binocular imbalance or strabismus .", + "entities": [] + }, + { + "id": "8223", + "type": "gene", + "text": "The immunophilin , which can be of the FK506 - or cyclosporin A - binding class , binds to hsp90 via its tetratricopeptide repeat ( TPR ) domain , and different receptor heterocomplexes exist depending upon which immunophilin occupies the TPR - binding region of hsp90 .", + "entities": [ + "immunophilin", + "hsp90", + "immunophilin", + "hsp90" + ] + }, + { + "id": "8224", + "type": "gene", + "text": "We report a case of vasculitis ( cutaneous and neurologic ) which led to the discovery of a selective immunodeficit towards EBV , similar to Purtilo ' s syndrome .", + "entities": [] + }, + { + "id": "8225", + "type": "gene", + "text": "The structural similarity between Vav and other guanine nucleotide exchange factors for small GTP - binding proteins , together with the recent identification of biochemical routes specific for members of the Ras and Rho family of GTPases , prompted us to explore whether MAPK or JNK are downstream components of the Vav signaling pathways .", + "entities": [ + "Vav", + "guanine nucleotide exchange factors", + "small GTP - binding proteins", + "Ras", + "Rho family", + "GTPases", + "MAPK", + "JNK", + "Vav" + ] + }, + { + "id": "8226", + "type": "gene", + "text": "Further characterization of these putative Hoxa - 1 target genes will aid in delineating the functions of the Hoxa - 1 protein in the differentiation processes which occur during embryogenesis .", + "entities": [ + "Hoxa - 1 target genes", + "Hoxa - 1 protein" + ] + }, + { + "id": "8227", + "type": "gene", + "text": "The observation of late effects after irradiations or after space flights show the difficulties encountered in assessing radiative risks during long duration space flights .", + "entities": [] + }, + { + "id": "8228", + "type": "gene", + "text": "High fibrinogen levels could thus be a risk for perioperative thrombosis .", + "entities": [ + "fibrinogen" + ] + }, + { + "id": "8229", + "type": "gene", + "text": "Evidence suggests that PHACES syndrome is not a random association but a true phakomatosis ; further studies are awaited to shed light on a possible genetic background .", + "entities": [] + }, + { + "id": "8230", + "type": "gene", + "text": "Its C - terminal catalytic domain was found to be highly conserved in the homologues p140 ( ras - GRF ) and Sos .", + "entities": [ + "p140", + "ras", + "GRF", + "Sos" + ] + }, + { + "id": "8231", + "type": "gene", + "text": "Eight hours after the administration of colchicine , the serum ceruloplasmin level began to rise again in female rats , but not in male rats .", + "entities": [ + "serum ceruloplasmin" + ] + }, + { + "id": "8232", + "type": "gene", + "text": "Looming detectors in the human visual pathway .", + "entities": [] + }, + { + "id": "8233", + "type": "gene", + "text": "Six patients with human T - cell lymphotropic virus type I ( HTLV - I ) - associated myelopathy ( HAM ) were studied by electrophysiologic methods .", + "entities": [] + }, + { + "id": "8234", + "type": "gene", + "text": "There is a cysteine clustering region in an N - terminal region of the c - raf ( - 1 ) product deduced from the nucleotide sequence , and this cysteine clustering region was found to be highly homologous to that present in an N - terminal region of protein kinase C , although , in the latter cysteine clusters are present in duplicate .", + "entities": [ + "c - raf ( - 1 ) product", + "protein kinase C" + ] + }, + { + "id": "8235", + "type": "gene", + "text": "Normal rates of weight gain were seen once absorbed energy intakes reached 100 - 110 % of requirements .", + "entities": [] + }, + { + "id": "8236", + "type": "gene", + "text": "CASE REPORT : Referred because of a right corneal perforation with cellular reaction in anterior chamber , a patient was sutured and treated with a single intravitreal injection of 0 . 2 ml ( 1 mg ) Amikacin and 0 . 2 ml ( 1 mg ) Vancomycin .", + "entities": [] + }, + { + "id": "8237", + "type": "gene", + "text": "The phosphorylation efficiency is improved by increasing the number of N - terminal arginine residues and by moving the arginyl cluster one residue further away from the serine , the nonapeptide ( Arg ) 4 - Ala - Ala - Ser - Val - Ala being the best substrate among all the short peptides tested ( Km = 15 microM ) .", + "entities": [] + }, + { + "id": "8238", + "type": "gene", + "text": "Overexpression of MDR1 has been demonstrated in many cancers , both in patient tumors and in cell lines selected with a variety of chemotherapeutic agents .", + "entities": [ + "MDR1" + ] + }, + { + "id": "8239", + "type": "gene", + "text": "However , neu differentiation factor - induced heterodimers of ErbB2 and ErbB4 activated Stat5 .", + "entities": [ + "neu", + "ErbB2", + "ErbB4", + "Stat5" + ] + }, + { + "id": "8240", + "type": "gene", + "text": "We have mapped the human STAG3 gene to the 7q22 region of chromosome 7 ; six human STAG3 - related genes have also been mapped : two at 7q22 near the functional gene , one at 7q11 . 22 , and three at 7q11 . 23 , two of them flanking the breakpoints commonly associated with the Williams - Beuren syndrome ( WBS ) deletion .", + "entities": [ + "human STAG3 gene", + "human STAG3 - related genes", + "Williams - Beuren syndrome ( WBS ) deletion" + ] + }, + { + "id": "8241", + "type": "gene", + "text": "TPO by itself did not activate ERK1 , ERK2 and protein kinase C ( PKC ) , whereas TPO directly enhanced the PKC - dependent activation of ERKs induced by other agonists including thrombin and phorbol esters , without affecting the PKC activation by those agonists .", + "entities": [ + "TPO", + "ERK1", + "ERK2", + "protein kinase C", + "PKC", + "TPO", + "PKC", + "ERKs", + "thrombin", + "PKC" + ] + }, + { + "id": "8242", + "type": "gene", + "text": "Sequencing the gene for an imipenem - cefoxitin - hydrolyzing enzyme ( CfiA ) from Bacteroides fragilis TAL2480 reveals strong similarity between CfiA and Bacillus cereus beta - lactamase II .", + "entities": [ + "CfiA", + "CfiA", + "Bacillus cereus beta - lactamase II" + ] + }, + { + "id": "8243", + "type": "gene", + "text": "In mouse , Mmip1 ( Mad member interacting protein 1 ) and Smc3 share 99 % sequence identity and are products of the same gene .", + "entities": [ + "Mmip1", + "Mad member interacting protein 1", + "Smc3" + ] + }, + { + "id": "8244", + "type": "gene", + "text": "NGF , but not EGF , enhances the upper bands , corresponding to phosphorylated Fra - 2 .", + "entities": [ + "NGF", + "EGF", + "phosphorylated Fra - 2" + ] + }, + { + "id": "8245", + "type": "gene", + "text": "Renal response to captopril in severe heart failure : role of furosemide in natriuresis and reversal of hyponatremia .", + "entities": [] + }, + { + "id": "8246", + "type": "gene", + "text": "High trough serum TOB concentrations were associated with death and very low levels with recovery .", + "entities": [] + }, + { + "id": "8247", + "type": "gene", + "text": "2 .", + "entities": [] + }, + { + "id": "8248", + "type": "gene", + "text": "The acids were obtained by hydrolysis of the corresponding esters , and their anti - inflammatory activity was tested .", + "entities": [] + }, + { + "id": "8249", + "type": "gene", + "text": "Constrictive pericarditis and pleuropulmonary disease linked to ergot dopamine agonist therapy ( cabergoline ) for Parkinson ' s disease .", + "entities": [] + }, + { + "id": "8250", + "type": "gene", + "text": "The aim of this study was to find out whether it was possible to detect normal lymph nodes by high - resolution mediastinal US .", + "entities": [] + }, + { + "id": "8251", + "type": "gene", + "text": "The [ 18F ] FMISO TMRR is a simple and clinically useful index for detecting tumour hypoxia in NPC .", + "entities": [] + }, + { + "id": "8252", + "type": "gene", + "text": "The characterization of the promoter region indicated that three distinct regulatory elements corresponding to an AP - 1 binding site ( or TRE ) , a PRDII / kappaB domain , and a CAAT box are involved in the activation by pp60 ( v - ) src .", + "entities": [ + "AP - 1 binding site", + "PRDII", + "kappaB", + "( v - ) src" + ] + }, + { + "id": "8253", + "type": "gene", + "text": "The Mean was 74 , 3 + / - 53 , 6 micrograms J / g Cr , the Median 61 micrograms J / g Cr .", + "entities": [] + }, + { + "id": "8254", + "type": "gene", + "text": "Records of 31 children with AIDS or AIDS - related complex admitted to the pediatric intensive care unit for acute respiratory failure throughout a 46 - month period were reviewed .", + "entities": [] + }, + { + "id": "8255", + "type": "gene", + "text": "And , most importantly , reconstitution of a consensus CRE , within the 21 - bp enhancers increases binding of CREB / ATF proteins but abrogates basal repression of LTR - directed transcription in vitro .", + "entities": [ + "CREB", + "ATF" + ] + }, + { + "id": "8256", + "type": "gene", + "text": "A 22K polypeptide was detected as a translation product of late RNA that hybridized to this DNA fragment .", + "entities": [] + }, + { + "id": "8257", + "type": "gene", + "text": "Analysis of the consensus binding sequence and the DNA - binding domain of ZF5 .", + "entities": [ + "ZF5" + ] + }, + { + "id": "8258", + "type": "gene", + "text": "This would have had the effect of positioning the genes currently on the long arm adjacent to the centromeric heterochromatin , perhaps resulting in a \" position effect \" on transcription of these genes .", + "entities": [] + }, + { + "id": "8259", + "type": "gene", + "text": "Retransformation of uvsH77 mutants with the rescued cosmids from the MMS - resistant transformants resulted in restoration of both UV and MMS resistance to wild - type levels .", + "entities": [ + "uvsH77 mutants" + ] + }, + { + "id": "8260", + "type": "gene", + "text": "Multiparous women presented higher BMI ( P = 0 . 01 ) and PBF ( P = 0 . 03 ) compared with primi - and nulliparous groups .", + "entities": [] + }, + { + "id": "8261", + "type": "gene", + "text": "The significance of structural integrity of lymphoid tissue for antibody production in culture in vivo", + "entities": [] + }, + { + "id": "8262", + "type": "gene", + "text": "METHODS : We retrospectively reviewed 242 adult cadaveric renal transplant recipients treated between 11 / 91 and 5 / 97 .", + "entities": [] + }, + { + "id": "8263", + "type": "gene", + "text": "The effect of these cell cycle regulators is not specific to the rap1s or hmr delta A mutation , since swi6 , swi4 , and clb5 mutations also suppress mutations in SIR1 , another gene implicated in the establishment of silencing .", + "entities": [ + "rap1s", + "hmr delta A mutation", + "swi6", + "swi4", + "clb5 mutations", + "SIR1" + ] + }, + { + "id": "8264", + "type": "gene", + "text": "Successful interaction of ARF and PKC - alpha with PLD1 was not achieved , but a C - terminal fragment of human PLD1 ( denoted \" D4 \" ) interacted with the active mutant of RhoA , RhoAVal - 14 .", + "entities": [ + "ARF", + "PKC - alpha", + "PLD1", + "human PLD1", + "RhoA", + "RhoAVal - 14" + ] + }, + { + "id": "8265", + "type": "gene", + "text": "In the multivariate analysis , six variables were independently correlated with survival : blood urea nitrogen level , serum aspartate aminotransferase level , community - acquired vs . hospital - acquired peritonitis , age , Child - Pugh score and ileus .", + "entities": [ + "serum aspartate aminotransferase" + ] + }, + { + "id": "8266", + "type": "gene", + "text": "Genomic libraries were stored as frozen cultures in a 96 - well format , each well containing approximately 300 - 600 colonies ( 12 plates for small library , four for medium - size library and four for large library ) .", + "entities": [] + }, + { + "id": "8267", + "type": "gene", + "text": "Efferent projections of the ventral portion of the putamen to the frontal , parietal and temporal regions of the cat cerebral cortex", + "entities": [] + }, + { + "id": "8268", + "type": "gene", + "text": "Productive growth of phage P22 in wild - type Salmonella typhimurium correlates with the presence of Abc2 , but is independent of the absolute level of ATP - dependent nuclease activity , suggesting a qualitative change in the nature of Abc2 - modified RecBCD nuclease activity relative to the native enzyme .", + "entities": [ + "Abc2", + "ATP - dependent nuclease", + "Abc2", + "RecBCD nuclease" + ] + }, + { + "id": "8269", + "type": "gene", + "text": "These results indicate that significant pulmonary metabolism of 5 - HT followed by efflux of 5 - HIAA into venous output occurs during single - pass circulation .", + "entities": [] + }, + { + "id": "8270", + "type": "gene", + "text": "Quantitative predictions are confirmed for the positive responses , but not for the negatives , suggesting that the SSTS model is incorrect .", + "entities": [] + }, + { + "id": "8271", + "type": "gene", + "text": "Among three isoforms , the beta isoform has the greatest Vmax value for the PtdIns ( 4 ) P kinase activity and the gamma isoform is most markedly stimulated by phosphatidic acid .", + "entities": [ + "PtdIns ( 4 ) P kinase" + ] + }, + { + "id": "8272", + "type": "gene", + "text": "Clinical and anatomical considerations", + "entities": [] + }, + { + "id": "8273", + "type": "gene", + "text": "In these experiments we begin to study the potential functions of the alpha 7 cytoplasmic domain by analyzing homologies between the rat and human sequences , by immunologic studies using an anti - cytoplasmic domain antiserum , and by identifying two alternate forms .", + "entities": [ + "alpha 7 cytoplasmic domain" + ] + }, + { + "id": "8274", + "type": "gene", + "text": "These results show that targeting of Ras - GAP could represent a novel anticancer approach .", + "entities": [ + "Ras", + "GAP" + ] + }, + { + "id": "8275", + "type": "gene", + "text": "Multiresistant strains isolated from humans in enteral toxico - infections kill orally infected mice more frequently than strains isolated in hospital infections .", + "entities": [] + }, + { + "id": "8276", + "type": "gene", + "text": "One phage clone contains a junction between alpha satellite DNA and a novel low - copy repeated sequence .", + "entities": [] + }, + { + "id": "8277", + "type": "gene", + "text": "An abundant 1 . 1 - kb virion - sense polyadenylated RNA and four complementary - sense polyadenylated RNAs of 1 . 7 , 1 . 5 , 1 . 3 , and 0 . 7 kb have been identified by northern blot hybridization , confirming the bidirectional transcription strategy implied by the arrangement of ORFs .", + "entities": [] + }, + { + "id": "8278", + "type": "gene", + "text": "A variety of professional and self - applied fluoride products are available and new fluoride delivery systems have recently entered the market .", + "entities": [] + }, + { + "id": "8279", + "type": "gene", + "text": "The p53 tumor suppressor gene product , a sequence - specific DNA - binding protein , has been shown to act as a transcriptional activator and repressor both in vitro and in vivo .", + "entities": [ + "p53 tumor suppressor gene product" + ] + }, + { + "id": "8280", + "type": "gene", + "text": "Twenty - three sequence - tagged sites ( STSs ) were mapped within the contig , a density of approximately 1 per 200 kb .", + "entities": [] + }, + { + "id": "8281", + "type": "gene", + "text": "Granulocyte colony - stimulating factor ( G - CSF ) administration in vivo has been shown to improve the defence mechanisms against infection by different microbes .", + "entities": [ + "Granulocyte colony - stimulating factor", + "G - CSF" + ] + }, + { + "id": "8282", + "type": "gene", + "text": "No homology was found between the 36K protein and known structures of proteins .", + "entities": [] + }, + { + "id": "8283", + "type": "gene", + "text": "Differentiating among renal stones .", + "entities": [] + }, + { + "id": "8284", + "type": "gene", + "text": "RESULTS : Fournier ' s gangrene occurs worldwide .", + "entities": [] + }, + { + "id": "8285", + "type": "gene", + "text": "Wnt - 1 ( int - 1 ) is a cellular oncogene often activated by insertion of proviral DNA of the mouse mammary tumor virus .", + "entities": [ + "Wnt - 1", + "int - 1" + ] + }, + { + "id": "8286", + "type": "gene", + "text": "These results suggest that N - nitroso compounds can be formed in vivo in the infected bladder , which could explain the association between urinary - tract infections and increased risk for bladder cancer .", + "entities": [] + }, + { + "id": "8287", + "type": "gene", + "text": "We describe 49 cases with papillary tumor < 1 cm .", + "entities": [] + }, + { + "id": "8288", + "type": "gene", + "text": "In a blind controlled trial , 15 patients with COCM ( NYHA II - III ) with sinus rhythm and a left ventricular ejection fraction ( LV - EF ) of 34 . 5 + / - 2 . 6 % received consecutively D ( 0 . 25 - 0 . 5 mg / d ) , placebo ( PLAC ) , P ( slow releases = SR ) ( 80 mg / d SR ) and both drugs combined in respective doses .", + "entities": [] + }, + { + "id": "8289", + "type": "gene", + "text": "We discuss the need to use animals older than 3 months for the study of ' adult ' regeneration phenomena since 3 - month - old rats may be somewhat immature .", + "entities": [] + }, + { + "id": "8290", + "type": "gene", + "text": "Hematocrit and PaO2 did not change .", + "entities": [] + }, + { + "id": "8291", + "type": "gene", + "text": "Overexpression of H411 cDNA in the RAW 264 . 7 macrophage cell line promoted an increased growth rate , suggesting that expression of H411 is part of the proliferative cell response to LPS .", + "entities": [ + "H411 cDNA", + "H411" + ] + }, + { + "id": "8292", + "type": "gene", + "text": "Peripheral polyneuropathy associated with multiple myeloma .", + "entities": [] + }, + { + "id": "8293", + "type": "gene", + "text": "Molecular cloning of the human homolog of a striatum - enriched phosphatase ( STEP ) gene and chromosomal mapping of the human and murine loci .", + "entities": [ + "( STEP ) gene" + ] + }, + { + "id": "8294", + "type": "gene", + "text": "Ten days of cefadroxil therapy was used to treat 44 children with urinary tract infection and CRP values greater than or equal to 28 microgram / ml ( CRP - positive group ) .", + "entities": [ + "CRP", + "CRP" + ] + }, + { + "id": "8295", + "type": "gene", + "text": "Among the patients grades 1 - 2 - 3 , 81 % had a good out come without any neurological abnormality , among the patients graded 4 - 5 , only 27 % had a fair out come .", + "entities": [] + }, + { + "id": "8296", + "type": "gene", + "text": "Structure of the EMAPII domain of human aminoacyl - tRNA synthetase complex reveals evolutionary dimer mimicry .", + "entities": [ + "EMAPII domain", + "human aminoacyl - tRNA synthetase complex" + ] + }, + { + "id": "8297", + "type": "gene", + "text": "Phase II study of VP - 16 ( capsule ) in solid tumors .", + "entities": [] + }, + { + "id": "8298", + "type": "gene", + "text": "Quantitative evaluation of magneto - optical parameters is necessary in order to apply scanning near - field optical microscope ( SNOM ) technology to the study of magnetism on the mesoscopic scale .", + "entities": [] + }, + { + "id": "8299", + "type": "gene", + "text": "Interestingly , the activity of IkappaB kinase ( IKK - beta ) , which plays an essential role in NF - kappaB activation through IkappaB phosphorylation , was largely enhanced in paclitaxel - treated cells , detected as IkappaBalpha phosphorylation .", + "entities": [ + "IkappaB kinase", + "IKK - beta", + "NF - kappaB", + "IkappaB", + "IkappaBalpha" + ] + }, + { + "id": "8300", + "type": "gene", + "text": "During a disease remission there was an increase in GAG secretion with urine , linked with hyperheparinuria ( 13 . 1 - fold , P less than 0 . 001 ) .", + "entities": [] + }, + { + "id": "8301", + "type": "gene", + "text": "The ubiquitous transcription factor Oct - 1 forms complexes with an octamer motif present within FPIV by gel shift analysis with liver and kidney extracts , making Oct - 1 an intriguing candidate for partnership in androgen regulation .", + "entities": [ + "Oct - 1", + "Oct - 1" + ] + }, + { + "id": "8302", + "type": "gene", + "text": "Renal clearance fell from 19 . 0 + / - 4 . 9 ml / min / 1 . 73 m2 ( group I ) to 1 . 0 + / - 0 . 4 ml / min / 1 . 73 m2 ( group IV ) .", + "entities": [] + }, + { + "id": "8303", + "type": "gene", + "text": "At the end of the experiment the urinary porphyrin excretion and the porphyrin content in lijver and skin were diminished in HCB - CQ - treated animals by about 50 % compared to the HCB controls .", + "entities": [] + }, + { + "id": "8304", + "type": "gene", + "text": "A second hydrophobic domain , bordered by two hydrophilic regions strongly suggests a transmembrane region .", + "entities": [] + }, + { + "id": "8305", + "type": "gene", + "text": "The data indicates the presence of 5 - HT2 serotonergic receptors in the bronchial artery of these species .", + "entities": [ + "5 - HT2 serotonergic receptors" + ] + }, + { + "id": "8306", + "type": "gene", + "text": "Our results indicate that the retroplasmid reverse transcriptase is uniquely adapted to initiate cDNA synthesis by recognizing a 3 ' CCA sequence .", + "entities": [ + "reverse transcriptase" + ] + }, + { + "id": "8307", + "type": "gene", + "text": "Thrombocyte function was impaired in all patients , characterized by a diminished platelet shape change .", + "entities": [] + }, + { + "id": "8308", + "type": "gene", + "text": "These single mutational defects in the eRF1 - eRF3 interaction became evident when either truncated protein eRF3C or C - terminally altered eRF1 proteins were used for the authentic protein , providing further support for the presence of a C - terminal interaction .", + "entities": [ + "eRF1", + "eRF3", + "eRF3C", + "eRF1" + ] + }, + { + "id": "8309", + "type": "gene", + "text": "Lck has been postulated to dimerize through the SH2 and SH3 domains .", + "entities": [ + "Lck", + "SH2", + "SH3 domains" + ] + }, + { + "id": "8310", + "type": "gene", + "text": "For pressure greater than 121 atm abs , an increased excitability of the tadpoles made it difficult to distinguish the righting reflex from involuntary movements .", + "entities": [] + }, + { + "id": "8311", + "type": "gene", + "text": "It appears that the pulmonary gas exchange parenchyma of these smallest mammals is well suited to supply the organism with the comparatively high levels of O2 required by the high metabolic rates , exhibiting a structural adaptation of the lung to higher VO2 .", + "entities": [] + }, + { + "id": "8312", + "type": "gene", + "text": "Renin secretion in essential and accelerated hypertension .", + "entities": [ + "Renin" + ] + }, + { + "id": "8313", + "type": "gene", + "text": "Atopic allergy and other hypersensitivities .", + "entities": [] + }, + { + "id": "8314", + "type": "gene", + "text": "Isolation and characterization of a TATA - less promoter for the human beta 3 integrin gene .", + "entities": [ + "human beta 3 integrin gene" + ] + }, + { + "id": "8315", + "type": "gene", + "text": "Preliminary experiments demonstrated that it was possible to produce fasD mutants , whose products remain functional for fimbrial export and assembly .", + "entities": [ + "fasD mutants" + ] + }, + { + "id": "8316", + "type": "gene", + "text": "AF154055 .", + "entities": [ + "AF154055" + ] + }, + { + "id": "8317", + "type": "gene", + "text": "Vivid visual hallucinations without other psychopathology have been reported for several hundred years .", + "entities": [] + }, + { + "id": "8318", + "type": "gene", + "text": "One of the sequelae of the antiphospholipid - antibodies is an impaired uteroplacental circulation .", + "entities": [] + }, + { + "id": "8319", + "type": "gene", + "text": "Furthermore , SB203580 inhibited LPS - induced activation of Sp1 , as well as the promoter activity in cells transfected with a plasmid containing the Sp1 consensus sequence .", + "entities": [ + "Sp1", + "Sp1" + ] + }, + { + "id": "8320", + "type": "gene", + "text": "Pb foil ( 0 . 55 gcm - 2 ) provided the best overall improvement .", + "entities": [] + }, + { + "id": "8321", + "type": "gene", + "text": "Finally , we compared the differential screening techniques in terms of sensitivity , efficiency and occurrence of false positives .", + "entities": [] + }, + { + "id": "8322", + "type": "gene", + "text": "Only two patients ( 0 . 3 % ) had a CA 125 response at the time of clinical progression .", + "entities": [ + "CA 125" + ] + }, + { + "id": "8323", + "type": "gene", + "text": "In 1990 , an International Commission for the Certification of Eradication of Poliomyelitis Eradication ( ICCPE ) was established by the Pan American Health Organization to eventually determine if transmission was interrupted .", + "entities": [] + }, + { + "id": "8324", + "type": "gene", + "text": "A split motor domain in a cytoplasmic dynein .", + "entities": [ + "cytoplasmic dynein" + ] + }, + { + "id": "8325", + "type": "gene", + "text": "The present research evaluated the possibility that polyethylene glycol 400 ( PEG 400 ) might be efficacious , toxic , or both .", + "entities": [] + }, + { + "id": "8326", + "type": "gene", + "text": "We found 14 protein binding sites that were occupied in vivo .", + "entities": [] + }, + { + "id": "8327", + "type": "gene", + "text": "The binary and tertiary combinations of plant - derived molluscicides Azadirachta indica and Cedrus deodara oil with synergists MGK - 264 , piperonyl butoxide ( PB ) and fruit powder of Embelia ribes were used against the Lymnaea acuminata .", + "entities": [] + }, + { + "id": "8328", + "type": "gene", + "text": "Overall least - squares means for uncooked and cooked longissimus muscle and subcutaneous fat were 63 . 32 , 80 . 27 and 98 . 90 mg of cholesterol / 100 g of tissue , respectively .", + "entities": [] + }, + { + "id": "8329", + "type": "gene", + "text": "Poor response when laboratory recommended range for serum lithium is changed .", + "entities": [] + }, + { + "id": "8330", + "type": "gene", + "text": "We found sequences related to this insertion in wild - type strains of N . crassa and other Neurospora species .", + "entities": [] + }, + { + "id": "8331", + "type": "gene", + "text": "Other hemostatic values evaluated were activated partial thromboplastin times , prothrombin times , thrombin times , fibrinogen , platelet counts , and fibrin / fibrinogen degradation products .", + "entities": [ + "thromboplastin", + "prothrombin", + "thrombin", + "fibrinogen", + "fibrin", + "fibrinogen" + ] + }, + { + "id": "8332", + "type": "gene", + "text": "Basal promoter activity is enhanced by a functional M1 domain in LHR - expressing mouse Leydig tumor cells ( MLTC ) but not in non - expressing CHO cells .", + "entities": [ + "LHR" + ] + }, + { + "id": "8333", + "type": "gene", + "text": "Number of patients infected with nontuberculous mycobacteria ( NTM ) is increasing world - wide in recent years .", + "entities": [] + }, + { + "id": "8334", + "type": "gene", + "text": "The operation recommended is excision of 3 mm of central slip followed by end - to - end repair of the tendon .", + "entities": [] + }, + { + "id": "8335", + "type": "gene", + "text": "Those dosages that inhibited mean NTE activity in spinal cord greater than or equal to 72 % and brain greater than or equal to 66 % of control values within 44 hr postexposure produced marked spinal cord pathology 14 days postexposure in greater than or equal to 90 % of similarly dosed animals .", + "entities": [ + "NTE" + ] + }, + { + "id": "8336", + "type": "gene", + "text": "Specific IgG , specific IgE and total IgE immunoglobulins against Toxocara canis excretory / secretory antigens ( TES ) were detected by using ELISA technique .", + "entities": [ + "IgG", + "IgE", + "IgE immunoglobulins", + "Toxocara canis excretory / secretory antigens", + "TES" + ] + }, + { + "id": "8337", + "type": "gene", + "text": "Two of seven initiation sites were flanked by a sequence homologous to the consensus promoter motif that includes the CRTA motif ( where R is A or G ) of the rice mitochondrion .", + "entities": [] + }, + { + "id": "8338", + "type": "gene", + "text": "Changes in ionic content of the mucous suggest that cholinergic mechanisms affect pressure in the excretory duct of the gland .", + "entities": [] + }, + { + "id": "8339", + "type": "gene", + "text": "To quantify any mechanical inhibitory effect of nasal intermittent positive pressure ventilation ( IPPV ) on inspiratory activity of the diaphragm we ventilated five conscious relaxed subjects on two occasions at respiratory rates similar to quiet breathing ( QB ) and at three levels of applied pressure ( Pappl ) - - 6 , 9 and 12 cmH2O , each during hypocapnia ( P ( CO2 ) allowed to decrease ) and eucapnia ( CO2 added to inspired gas ) .", + "entities": [] + }, + { + "id": "8340", + "type": "gene", + "text": "Therefore , in a large animal model of permanent focal ischemia in which transfusion starts 30 min after ischemia , tetrameric cross - linked hemoglobin transfusion can augment oxygen transport to the ischemic cortex , but the increase can be delayed and not necessarily provide protection .", + "entities": [ + "hemoglobin" + ] + }, + { + "id": "8341", + "type": "gene", + "text": "Furthermore , 45Ca - binding assays revealed that CCaMK directly binds Ca2 + .", + "entities": [ + "CCaMK" + ] + }, + { + "id": "8342", + "type": "gene", + "text": "Constipation is not a risk factor for hemorrhoids : a case - control study of potential etiological agents .", + "entities": [] + }, + { + "id": "8343", + "type": "gene", + "text": "The test was not performed in 3923 patients because of contraindications .", + "entities": [] + }, + { + "id": "8344", + "type": "gene", + "text": "In addition , the gcd1 - 101 mutation suppressed the low translational efficiency of GCN4 - lacZ mRNA observed in gcn2 - and gcn3 - cells .", + "entities": [ + "gcd1 - 101 mutation", + "GCN4", + "lacZ", + "gcn2 -", + "gcn3 -" + ] + }, + { + "id": "8345", + "type": "gene", + "text": "The skin site , 6 - cm - distal and - proximal subcutaneous segments of the catheter , exudates , and blood were cultured .", + "entities": [] + }, + { + "id": "8346", + "type": "gene", + "text": "It then merged with right ventricular wavefronts ending along the right ventricular anterior atrioventricular groove and outflow tract .", + "entities": [] + }, + { + "id": "8347", + "type": "gene", + "text": "These mutants were tested for ability to bind each of the Site II cognate proteins , and subsequently evaluated for ability to confer H4 transcriptional activity using chimeric H4 promoter / CAT fusion constructs in different cell types .", + "entities": [ + "Site II cognate proteins", + "H4", + "H4", + "CAT" + ] + }, + { + "id": "8348", + "type": "gene", + "text": "PNT , ADD and BSS in the initial stage of kindling , kindling rate for the stage - 3 and - 5 seizures , seizure parameters at the first stage - 3 and - 5 were recorded and compared to the values of saline - treated , control group .", + "entities": [] + }, + { + "id": "8349", + "type": "gene", + "text": "Moreover , elderly men with bioavailable estradiol levels below the median [ 40 pmol / liter ( 11 pg / ml ) ] had significantly higher rates of bone loss and levels of bone resorption markers than men with bioavailable estradiol levels above 40 pmol / liter .", + "entities": [] + }, + { + "id": "8350", + "type": "gene", + "text": "Primer extension experiments showed that there are two transcription initiation sites 16 bp apart in the mouse type 2 receptor gene .", + "entities": [ + "mouse type 2 receptor gene" + ] + }, + { + "id": "8351", + "type": "gene", + "text": "The procedure facilitated the retention of a mandibular molar with a Class III FI in a manner acceptable to both the patient and the clinician .", + "entities": [] + }, + { + "id": "8352", + "type": "gene", + "text": "By contrast , deletion of this Ras - binding site did not diminish activation of Raf - 1 kinase by Src , implying that Src and Ras can activate Raf - 1 through independent mechanisms .", + "entities": [ + "Ras - binding site", + "Raf - 1 kinase", + "Src", + "Src", + "Ras", + "Raf - 1" + ] + }, + { + "id": "8353", + "type": "gene", + "text": "The major neurological manifestations of brain injury in these babies are spastic motor deficits .", + "entities": [] + }, + { + "id": "8354", + "type": "gene", + "text": "Translational fusions of the aroF regulatory regions to lacZ were constructed and then introduced in single copy into the E . coli chromosome .", + "entities": [ + "aroF regulatory regions", + "lacZ" + ] + }, + { + "id": "8355", + "type": "gene", + "text": "beta - Galactosidase assays for tyrR - mediated regulation of aroF - lacZ expression revealed that the E . coli TyrR repressor apparently recognizes the operators of both organisms with about equal efficiency .", + "entities": [ + "beta - Galactosidase", + "aroF", + "lacZ", + "E . coli TyrR repressor" + ] + }, + { + "id": "8356", + "type": "gene", + "text": "Cyclin D1 promoter activity was stimulated by overexpression of mitogen - activated protein kinase ( p41MAPK ) or c - Ets - 2 through the proximal 22 base pairs .", + "entities": [ + "Cyclin D1 promoter", + "mitogen - activated protein kinase", + "p41MAPK", + "c - Ets - 2" + ] + }, + { + "id": "8357", + "type": "gene", + "text": "The ESEM differs from conventional SEM in that no sample preparation is needed , eliminating artifactual changes .", + "entities": [] + }, + { + "id": "8358", + "type": "gene", + "text": "Crisis of the therapeutic community in Great Britain", + "entities": [] + }, + { + "id": "8359", + "type": "gene", + "text": "A cDNA cloning vector that permits expression of cDNA inserts in mammalian cells .", + "entities": [] + }, + { + "id": "8360", + "type": "gene", + "text": "Facioscapulohumeral muscular dystrophy ( FSHD ) is an autosomal dominant , neuromuscular disorder characterized by progressive weakness of muscles in the face , shoulder and upper arm .", + "entities": [] + }, + { + "id": "8361", + "type": "gene", + "text": "Experiment 3 showed that the long - term analgesic reaction could also be reduced by administration of naltrexone prior to reexposure to shock .", + "entities": [] + }, + { + "id": "8362", + "type": "gene", + "text": "New alkaloids from bark of Erythrophleum ivorense .", + "entities": [] + }, + { + "id": "8363", + "type": "gene", + "text": "The DNA binding activities of the three repressor preparations were studied using fragments containing CIRs ( CIR3 - CIR6 ) from the essential early region as templates for DNase I footprinting .", + "entities": [ + "DNase I" + ] + }, + { + "id": "8364", + "type": "gene", + "text": "The mass - specific resting minute ventilation ( E ) and the ventilatory equivalent ( VE / ( O ( 2 ) ) ) were approximately the same at the two ages , with a breathing pattern significantly deeper and slower at day 1 .", + "entities": [] + }, + { + "id": "8365", + "type": "gene", + "text": "At all time - points , most patients ( > / = 87 % ) were receiving irbesartan / HCTZ alone .", + "entities": [] + }, + { + "id": "8366", + "type": "gene", + "text": "SCL prolonged promptly after verapamil , and sinus arrest developed in two of 10 group 2 and two of five group 3 animals .", + "entities": [] + }, + { + "id": "8367", + "type": "gene", + "text": "A randomized , multicenter study comparing the efficacy and tolerability of tropisetron , a new 5 - HT3 receptor antagonist , with a metoclopramide - containing antiemetic cocktail in the prevention of cisplatin - induced emesis .", + "entities": [ + "5 - HT3 receptor" + ] + }, + { + "id": "8368", + "type": "gene", + "text": "Adenyl cyclase activity of gastric mucosa in patients with duodenal ulcer before and after treatment", + "entities": [ + "Adenyl cyclase" + ] + }, + { + "id": "8369", + "type": "gene", + "text": "A high - efficiency cross - flow micronebulizer interface for capillary electrophoresis and inductively coupled plasma mass spectrometry .", + "entities": [] + }, + { + "id": "8370", + "type": "gene", + "text": "The data indicate that the minimal catalytic domain of Nmt1p is located between Ile59 - - > Phe96 and Gly451 - - > Leu455 .", + "entities": [ + "Nmt1p" + ] + }, + { + "id": "8371", + "type": "gene", + "text": "This negative element may , at least in part , be responsible for the cell type - specific expression of the DGK gene .", + "entities": [ + "DGK gene" + ] + }, + { + "id": "8372", + "type": "gene", + "text": "Horseradish peroxidase as a permeability marker in injured rat caudal and iliac arteries .", + "entities": [ + "Horseradish peroxidase" + ] + }, + { + "id": "8373", + "type": "gene", + "text": "Reaction time ( RT ) and P300 were collected simultaneously .", + "entities": [] + }, + { + "id": "8374", + "type": "gene", + "text": "Following treatment , serum estradiol levels were higher in groups E + T and E than in group C .", + "entities": [] + }, + { + "id": "8375", + "type": "gene", + "text": "Northern blot analysis revealed that mlt 1 is normally expressed in brain , spleen , stom ach , and liver .", + "entities": [ + "mlt 1" + ] + }, + { + "id": "8376", + "type": "gene", + "text": "Inhibition of erythromycin synthesis by disruption of malonyl - coenzyme A decarboxylase gene eryM in Saccharopolyspora erythraea .", + "entities": [ + "eryM" + ] + }, + { + "id": "8377", + "type": "gene", + "text": "In addition , the DNA - binding experiments show that either one of the two MADS domains of a dimer can be sufficient to confer a particular DNA - binding specificity to the complex and that sequences outside the amino - terminal basic region of the MADS domain can , in some cases , contribute to the DNA - binding specificity of the proteins .", + "entities": [ + "MADS domains", + "MADS" + ] + }, + { + "id": "8378", + "type": "gene", + "text": "The integration at the VIP CyRE of the Jak - Stat and AP - 1 signaling pathways with other pre - existing proteins provides a cellular mechanism for cell - and cytokine - specific signaling .", + "entities": [ + "CyRE", + "Jak", + "Stat", + "AP - 1" + ] + }, + { + "id": "8379", + "type": "gene", + "text": "All 13 patients showed endoscopic evidence of oesophagitis , moderate in 4 and severe in 9 .", + "entities": [] + }, + { + "id": "8380", + "type": "gene", + "text": "Therefore , both the Chilean and the Japanese samples collected in high - risk areas showed higher mutagenic rates than the Japanese ones in a low - risk area , with a statistical significance ( p < 0 . 001 ) , chi - square test ) .", + "entities": [] + }, + { + "id": "8381", + "type": "gene", + "text": "The substrates for glycan synthesis in the lumen of the Golgi are nucleotide sugars that must be transported from the cytosol by specific membrane - bound transporters .", + "entities": [] + }, + { + "id": "8382", + "type": "gene", + "text": "The hexanucleotide 5 ' - TGTCCT - 3 ' , thought to be important for GRE activity , not only was found in this sequence and in the 5 ' - flanking region , but also was present twice in the 3 ' end of the gene that did not show specific receptor binding .", + "entities": [] + }, + { + "id": "8383", + "type": "gene", + "text": "It is concluded that opiate receptors bordering the fourth cerebral ventricle mediate the cardiovascular and hypnotic action of fentanyl .", + "entities": [ + "opiate receptors" + ] + }, + { + "id": "8384", + "type": "gene", + "text": "Association of human Pur alpha with the retinoblastoma protein , Rb , regulates binding to the single - stranded DNA Pur alpha recognition element .", + "entities": [ + "human Pur alpha", + "retinoblastoma protein", + "Rb", + "Pur alpha recognition element" + ] + }, + { + "id": "8385", + "type": "gene", + "text": "Here we investigate the role of c - Cbl in development and homeostasis in mice by targeted disruption of the c - Cbl locus .", + "entities": [ + "c - Cbl", + "c - Cbl locus" + ] + }, + { + "id": "8386", + "type": "gene", + "text": "c - Cbl - deficient mice were viable , fertile , and outwardly normal in appearance .", + "entities": [ + "c - Cbl" + ] + }, + { + "id": "8387", + "type": "gene", + "text": "It is possible that cyclic variations in heme turnover are related to changes in erythrocyte characteristics during the progesterone phase .", + "entities": [] + }, + { + "id": "8388", + "type": "gene", + "text": "A total of 90 patients were randomly allocated either to an MY - 1 treated or an untreated group .", + "entities": [] + }, + { + "id": "8389", + "type": "gene", + "text": "The molecular associations dictating INCENP behavior during mitosis are currently unknown .", + "entities": [ + "INCENP" + ] + }, + { + "id": "8390", + "type": "gene", + "text": "For comparison conventional heparin was used during 18 dialyses in the same patients .", + "entities": [] + }, + { + "id": "8391", + "type": "gene", + "text": "Electrophoretic mobility shift assays demonstrated specific nuclear protein binding to - 85 / - 64 , and single point mutations suggested important binding nucleotides between - 79 / - 68 with five critical bases between - 74 / - 70 ( 5 ' - CTCCT - 3 ' ) .", + "entities": [] + }, + { + "id": "8392", + "type": "gene", + "text": "To study the structure - function of the gene 5 product , wild - type and mutant forms of NS53 were produced by using a recombinant baculovirus expression system and a recombinant vaccinia virus / T7 ( vTF7 - 3 ) expression system .", + "entities": [ + "gene 5 product", + "NS53" + ] + }, + { + "id": "8393", + "type": "gene", + "text": "Notice of retraction .", + "entities": [] + }, + { + "id": "8394", + "type": "gene", + "text": "The difference of hardness over time of composite specimens was measured using Knoop hardness measurements taken at the top and bottom surfaces of resin specimens made in a Teflon mold the same dimensions as the cavity prepared in dentin .", + "entities": [] + }, + { + "id": "8395", + "type": "gene", + "text": "Using 16 strains of C . trachomatis in triplicate assays , we found the RT - PCR method consistently more sensitive than the conventional technique for all eight antimicrobials tested , with resultant MICs determined by RT - PCR ranging from 1 . 6 - fold higher ( erythromycin ) to > / = 195 - fold higher ( amoxicillin ) .", + "entities": [] + }, + { + "id": "8396", + "type": "gene", + "text": "Suggestive evidence was obtained that cstA is involved in peptide utilization .", + "entities": [ + "cstA" + ] + }, + { + "id": "8397", + "type": "gene", + "text": "These data suggest that combined lesions of cholinergic and serotonergic neurons in the rat brain do not alter olfactory perception or olfactory short - term memory .", + "entities": [] + }, + { + "id": "8398", + "type": "gene", + "text": "The gene contains six exons separated by 1 . 1 - 5 . 8 kb introns and has been localized to the murine chromosome 2 by linkage analysis .", + "entities": [] + }, + { + "id": "8399", + "type": "gene", + "text": "Characterization of LRP , a leucine - rich repeat ( LRR ) protein from tomato plants that is processed during pathogenesis .", + "entities": [ + "LRP", + "leucine - rich repeat ( LRR ) protein from tomato plants" + ] + }, + { + "id": "8400", + "type": "gene", + "text": "The 5 ' flanking region of the CD1 gene contained the binding motifs for two cytokine - inducible transcription factors , NF - IL2 - A and NF - IL6 .", + "entities": [ + "CD1 gene", + "NF - IL2 - A", + "NF - IL6" + ] + }, + { + "id": "8401", + "type": "gene", + "text": "HexA71 negatively affects RpoS , as the levels of this alternative sigma factor are higher in the HexA - mutant than in the HexA + strain .", + "entities": [ + "HexA71", + "RpoS", + "sigma factor", + "HexA - mutant", + "HexA +" + ] + }, + { + "id": "8402", + "type": "gene", + "text": "Each parent interacted with their 4 - or 5 - year - old son or daughter in each of two conversations - - unstructured ( social conversation ) and structured ( task activity ) .", + "entities": [] + }, + { + "id": "8403", + "type": "gene", + "text": "The nucleotide sequence of 3874 bp of cloned R . sphaeroides chromosomal DNA , including the three structural genes fbcF , fbcB and fbcC has been determined .", + "entities": [ + "fbcF", + "fbcB", + "fbcC" + ] + }, + { + "id": "8404", + "type": "gene", + "text": "Our findings confirm the high frequency of proximal nerve lesions in early GBS and CIDP , not all of which are associated with distal motor conduction abnormalities , and suggest that assessment of multiple F wave parameters , in particular chronodispersion , mean latency and mean amplitude ( in addition to absence and minimum latency ) , increases the yield of F wave studies .", + "entities": [] + }, + { + "id": "8405", + "type": "gene", + "text": "The structural genes encoding glyceraldehyde - 3 - phosphate dehydrogenase ( GAPDH ) , 3 - phosphoglycerate kinase ( PGK ) and the N - terminal part of triosephosphate isomerase ( TIM ) from mesophilic Bacillus megaterium DSM319 have been cloned as a gene cluster ( gap operon ) by complementation of an Escherichia coli gap amber mutant .", + "entities": [ + "glyceraldehyde - 3 - phosphate dehydrogenase", + "GAPDH", + "3 - phosphoglycerate kinase", + "PGK", + "triosephosphate isomerase", + "TIM", + "gap operon", + "gap amber mutant" + ] + }, + { + "id": "8406", + "type": "gene", + "text": "Moreover , moderate overexpression of Chk1 suppresses the phenotypes of cut5 and crb2 mutants .", + "entities": [ + "Chk1", + "cut5", + "crb2 mutants" + ] + }, + { + "id": "8407", + "type": "gene", + "text": "Requirements for the nuclear - cytoplasmic translocation of infected - cell protein 0 of herpes simplex virus 1 .", + "entities": [ + "infected - cell protein 0" + ] + }, + { + "id": "8408", + "type": "gene", + "text": "The methylation of nuclear and chloroplast DNAs has been examined in relation to the known differential expression of C4 photosynthesis genes in the bundle sheath and mesophyll cells of etiolated , greening , and fully green maize leaves .", + "entities": [ + "C4 photosynthesis genes" + ] + }, + { + "id": "8409", + "type": "gene", + "text": "The mature protein also contains a cysteine - rich , highly hydrophilic region homologous to the ovomucoid serine protease inhibitors ( residues 76 - 132 ) .", + "entities": [ + "ovomucoid serine protease inhibitors" + ] + }, + { + "id": "8410", + "type": "gene", + "text": "The amino acid sequence of the protein in the region of the specificity pocket is similar to that of S . griseus proteases A , B , and C .", + "entities": [ + "S . griseus proteases A , B , and C" + ] + }, + { + "id": "8411", + "type": "gene", + "text": "State - approved schools of nursing - - R . N . , 1972 .", + "entities": [] + }, + { + "id": "8412", + "type": "gene", + "text": "The complete cDNA sequence of human betaV spectrin is available from GenBank ( TM ) as accession number .", + "entities": [ + "human betaV spectrin" + ] + }, + { + "id": "8413", + "type": "gene", + "text": "The results show that ROS production by viable spermatozoa is highly correlated with the concentration of PMN elastase and the number of both peroxidase - positive and round cells .", + "entities": [ + "PMN elastase", + "peroxidase" + ] + }, + { + "id": "8414", + "type": "gene", + "text": "Orthop .", + "entities": [] + }, + { + "id": "8415", + "type": "gene", + "text": "Deletion of a 53 - bp early promoter region containing the transcription start site and a putative TATA box completely abolishes the ability of upstream elements to drive transcription of the luciferase cDNA .", + "entities": [ + "luciferase cDNA" + ] + }, + { + "id": "8416", + "type": "gene", + "text": "The corresponding inhibition of acid phosphatase activity in control male and female guinea pigs was 15 . 91 % and 20 . 33 % respectively .", + "entities": [ + "acid phosphatase" + ] + }, + { + "id": "8417", + "type": "gene", + "text": "Natl .", + "entities": [] + }, + { + "id": "8418", + "type": "gene", + "text": "We also present evidence for a negative regulatory element in the 5 ' flanking region of the Mlu I upstream activation sequence .", + "entities": [ + "Mlu I upstream activation sequence" + ] + }, + { + "id": "8419", + "type": "gene", + "text": "The requirement of Tyr - 19 dephosphorylation for spindle assembly is also observed under conditions in which spindle formation is independent of mitosis , suggesting that the involvement of Cdc28 / Clb kinase in SPB separation is direct .", + "entities": [ + "Cdc28", + "Clb" + ] + }, + { + "id": "8420", + "type": "gene", + "text": "Light microscopical and routine immunohistochemical studies of a cervical neoplasm in a 32 year old woman initially suggested a histiocytic lymphoma , but histochemical staining for chloroacetate esterase established the correct diagnosis .", + "entities": [ + "chloroacetate esterase" + ] + }, + { + "id": "8421", + "type": "gene", + "text": "Km and Vmax for two substrates , src - related peptide and poly ( Glu , Tyr ) ( 4 : 1 ) , were 2 . 4 mM and 2 . 5 mumol min - 1 mg - 1 and 0 . 26 mM and 1 . 2 mumol min - 1 mg - 1 , respectively .", + "entities": [ + "src - related peptide" + ] + }, + { + "id": "8422", + "type": "gene", + "text": "A single i . p . injection of d , l - baclofen 10 mg / kg both reduced noradrenaline ( NA ) biosynthesis in vivo ( 31 % ) and the endogenous concentration of normetanephrine ( NMN ) ( 32 % ) and increased NA levels ( 28 % ) .", + "entities": [] + }, + { + "id": "8423", + "type": "gene", + "text": "Distribution and changing morphological course", + "entities": [] + }, + { + "id": "8424", + "type": "gene", + "text": "Molecular cloning , expression pattern , and chromosomal localization of human CDKN2D / INK4d , an inhibitor of cyclin D - dependent kinases .", + "entities": [ + "CDKN2D", + "INK4d", + "cyclin D - dependent kinases" + ] + }, + { + "id": "8425", + "type": "gene", + "text": "TCZ provides quick , inexpensive , noninvasive indication of tissue necrosis , moderate - to - severe intracranial hemorrhage , and delayed brain maturation .", + "entities": [] + }, + { + "id": "8426", + "type": "gene", + "text": "These results demonstrate that N - glycans flanking the receptor - binding site of the HA molecule are potent regulators of influenza virus growth , with the glycan at Asn149 being dominant and that at Asn123 being less effective .", + "entities": [ + "HA molecule" + ] + }, + { + "id": "8427", + "type": "gene", + "text": "Impaction of gastrostomy tube in the abdominal wall .", + "entities": [] + }, + { + "id": "8428", + "type": "gene", + "text": "A genetic complementation system was developed in which tobacco etch virus ( TEV ) polymerase ( NIb ) - expressing transgenic plants or protoplasts were inoculated with NIb - defective TEV mutants .", + "entities": [ + "tobacco etch virus ( TEV ) polymerase", + "NIb", + "NIb", + "TEV mutants" + ] + }, + { + "id": "8429", + "type": "gene", + "text": "Purified CarP binds in vitro to the carAB control region and protects against DNase I two approximately 25 bp long stretches , one of which is located just downstream of the GATC sequence .", + "entities": [ + "CarP", + "carAB control region", + "DNase I" + ] + }, + { + "id": "8430", + "type": "gene", + "text": "Lysosomal enzymes that degrade cartilage are released .", + "entities": [] + }, + { + "id": "8431", + "type": "gene", + "text": "UPMC is not the only organization pursuing controlled NHBC organ procurement , however .", + "entities": [] + }, + { + "id": "8432", + "type": "gene", + "text": "Here we report that expression of the I - POU / tI - POU message is maximal late in the embryonic phase of Drosophila development , and I - POU is the preferred splice variant .", + "entities": [ + "I - POU", + "tI - POU", + "I - POU" + ] + }, + { + "id": "8433", + "type": "gene", + "text": "In some cases , factor - induced Rac activation results in Rho activation , and factor - induced Cdc42 activation leads to Rac activation , as determined by specific morphological changes .", + "entities": [ + "Rac", + "Rho", + "Cdc42", + "Rac" + ] + }, + { + "id": "8434", + "type": "gene", + "text": "According to out field research , the tick fauna was very rich throughout that area , and it was permissible enough to determine ticks as the vectors , based on arising of anti - SF group rickettsiae ( SFGR ) antibody in mice inoculated with some tick emulsions , findings of rickettsiae reactive to patient sera or a species - specific monoclonal antibody to JSFR in the hemolymph cells of some ticks , and electron microscopical observations of SFGR in various internal organs including the salivary gland of ticks .", + "entities": [ + "anti - SF group rickettsiae", + "SFGR", + "JSFR", + "SFGR" + ] + }, + { + "id": "8435", + "type": "gene", + "text": "An unusual complication in an unsuitable patient .", + "entities": [] + }, + { + "id": "8436", + "type": "gene", + "text": "We conclude that cephalothin clearance of S . aureus from a site accessible to phagocytes was delayed when compared to a phagocyte - inaccessible site .", + "entities": [] + }, + { + "id": "8437", + "type": "gene", + "text": "Despite resolution of the solid portion of the tumor , serial MRI showed enlargement of a bilobar tumor cyst 3 years after the original diagnosis .", + "entities": [] + }, + { + "id": "8438", + "type": "gene", + "text": "The protein predicted by the sequence of the human pim - 1 proto - oncogene shares extensive homology with known serine / threonine protein kinases , and yet the human Pim - 1 enzyme has previously been reported to exhibit protein tyrosine kinase activity both in vitro and in vivo .", + "entities": [ + "human pim - 1 proto - oncogene", + "serine / threonine protein kinases", + "human Pim - 1 enzyme", + "protein tyrosine kinase" + ] + }, + { + "id": "8439", + "type": "gene", + "text": "Controlled versus uncontrolled reperfusion of ischemic myocardium after experimental coronary artery occlusion was studied to determine the effect on regional ventricular wall motion and associated biochemical alterations .", + "entities": [] + }, + { + "id": "8440", + "type": "gene", + "text": "These results strongly suggest that locally - applied TTC in combination with FDBA enhances new bone formation in experimental alveolar bone defects .", + "entities": [] + }, + { + "id": "8441", + "type": "gene", + "text": "Morphine injected into the lateral ventricle of the rat produced unilateral analgesia in the formalin test , which involves continuous , moderate pain .", + "entities": [] + }, + { + "id": "8442", + "type": "gene", + "text": "Molecular cloning and characterization of two genes encoding gp138 , a cell surface glycoprotein involved in the sexual cell fusion of Dictyostelium discoideum .", + "entities": [ + "genes encoding gp138" + ] + }, + { + "id": "8443", + "type": "gene", + "text": "As a consequence of dark rearing , the numerical density of cortical neurons in area 17 amounted to about double of the value observed in normally reared kittens and was also significantly higher in area 18 .", + "entities": [] + }, + { + "id": "8444", + "type": "gene", + "text": "Synchronous extracts showed no significant migration inhibition in allogeneic assays .", + "entities": [] + }, + { + "id": "8445", + "type": "gene", + "text": "This interaction occurs over a wide range of both parameters ; for charge density from at least 10 to 800 microC / cm2 and , for charge per phase , from at least 0 . 05 to 5 . 0 microC per phase .", + "entities": [] + }, + { + "id": "8446", + "type": "gene", + "text": "Evidence forthe electroosmosis theory of transport in the phloem .", + "entities": [] + }, + { + "id": "8447", + "type": "gene", + "text": "The first algorithm , FOREPROJ , is a fast - forward projection algorithm that allows calculation of the 3 - D attenuation correction factors ( ACF ' s ) directly from a two - dimensional ( 2 - D ) transmission scan , without first reconstructing the attenuation map and then performing a 3 - D forward projection .", + "entities": [] + }, + { + "id": "8448", + "type": "gene", + "text": "The rCBF ratio was mainly reduced in frontal lobes ( 65 % ) .", + "entities": [] + }, + { + "id": "8449", + "type": "gene", + "text": "Platelet function and platelet - polymorphonuclear - neutrophil interaction in patients with deficient platelet lipoxygenase activity .", + "entities": [ + "platelet lipoxygenase" + ] + }, + { + "id": "8450", + "type": "gene", + "text": "The clinical and laboratory features of 72 children with Henoch - Schonlein purpura ( HSP ) were examined to determine if there were associations between the laboratory indices - - including white blood cell ( WBC ) counts , serum C - reactive protein ( CRP ) levels , platelet ( PLT ) counts - - and the clinical manifestations of acute HSP .", + "entities": [ + "serum C - reactive protein", + "CRP" + ] + }, + { + "id": "8451", + "type": "gene", + "text": "The sequences showed extensive homologies with squalene synthase genes and enzymes from a number of other organisms and extreme amino acid conservation within the binding and catalytic domains .", + "entities": [ + "squalene synthase genes" + ] + }, + { + "id": "8452", + "type": "gene", + "text": "We introduced the gel technique as a routine assay for antibody detection and identification in 1993 .", + "entities": [] + }, + { + "id": "8453", + "type": "gene", + "text": "Selection using SC EPD was more effective than phenotypic selection in reducing age at puberty in daughters .", + "entities": [] + }, + { + "id": "8454", + "type": "gene", + "text": "Materials science studies on the soldering of different orthodontic wires", + "entities": [] + }, + { + "id": "8455", + "type": "gene", + "text": "In contrast , the loss of MAD2 staining in meiosis was not correlated with initial microtubule attachment but was correlated with a measure of tension : the distance between homologous or sister kinetochores ( in meiosis I and II , respectively ) .", + "entities": [ + "MAD2" + ] + }, + { + "id": "8456", + "type": "gene", + "text": "The uterine response to prostaglandin E2 ( PGE2 ) and prostaglandin F2alpha ( administered by intravenous and intrauterine routes ) was evaluated during different phases of the menstrual cycle in five functionally infertile women .", + "entities": [] + }, + { + "id": "8457", + "type": "gene", + "text": "AIMS : To establish a baseline and intraindividual fluctuations of the tumour markers CEA , CA 50 and CA 242 in patients cured from colorectal cancer , and to test the hypothesis that serum concentrations and intraindividual fluctuations do not differ from the concentrations in cancer - free individuals .", + "entities": [ + "CEA", + "CA 50", + "CA 242" + ] + }, + { + "id": "8458", + "type": "gene", + "text": "ROS x SRC ( R ) contains a 16 - amino - acid deletion that includes the 3 ' half of the transmembrane domain of ros .", + "entities": [ + "ROS", + "SRC", + "R", + "ros" + ] + }, + { + "id": "8459", + "type": "gene", + "text": "Phosphate glucose dehydrogenase deficiency causing hyperbilirubinemia in the newborn", + "entities": [ + "Phosphate glucose dehydrogenase" + ] + }, + { + "id": "8460", + "type": "gene", + "text": "Survival rates for the original treatment group were 84 . 5 % and 57 . 6 % at 12 and 21 months , respectively ; for the delayed treatment group , 78 . 8 % and 64 . 6 % at 12 and 21 months , respectively , and 78 . 8 % and 47 . 5 % at 12 and 21 months , respectively , for 77 subjects with AIDS and 93 . 0 % and 71 . 8 % , respectively , for 50 subjects with AIDS - related complex in the original treatment group .", + "entities": [] + }, + { + "id": "8461", + "type": "gene", + "text": "Interspecific mouse back - cross analysis identified the loci for mouse 3Ost genes and syntenic assignments of corresponding human isologs were confirmed by the identification of mapped sequence - tagged site markers .", + "entities": [ + "mouse 3Ost genes" + ] + }, + { + "id": "8462", + "type": "gene", + "text": "We speculate that these tumors may represent congenital hamartomatous growths .", + "entities": [] + }, + { + "id": "8463", + "type": "gene", + "text": "To lower the current high incidence of NANB - induced PTH , in 1986 , the American Association of Blood Banks ( AABB ) recommended testing for these PTH - associated \" surrogate \" markers on all donated units of blood .", + "entities": [] + }, + { + "id": "8464", + "type": "gene", + "text": "Isolation of Aeromonas from faeces .", + "entities": [] + }, + { + "id": "8465", + "type": "gene", + "text": "The uptake of fluorine - 18 fluorodeoxyglucose ( F - 18 FDG ) by a malignant tumor depends on the blood glucose level .", + "entities": [] + }, + { + "id": "8466", + "type": "gene", + "text": "Fine analysis at the nucleotide level of the early events in the digestion with nuclease S1 shows that the enzyme attacks preferentially the sequence ( G - A ) 12 on the message complementary strand .", + "entities": [ + "nuclease S1" + ] + }, + { + "id": "8467", + "type": "gene", + "text": "Renal excretion of sulphadimidine in normal and uraemic subjects .", + "entities": [] + }, + { + "id": "8468", + "type": "gene", + "text": "Mean corpuscular hemoglobin concentrations remained normal for 48 h and then decreased in both groups , the CO2 group showing the larger decrease .", + "entities": [ + "corpuscular hemoglobin" + ] + }, + { + "id": "8469", + "type": "gene", + "text": "A total of 174 primer pairs gave interpretable banding patterns , 137 ( 79 % ) of which revealed at least two alleles on native polyacrylamide gels .", + "entities": [] + }, + { + "id": "8470", + "type": "gene", + "text": "CONCLUSIONS : Adding MMF , a potent topical corticosteroid , to an emollient cream is statistically significantly more effective than emollient cream alone in reducing acute radiation dermatitis .", + "entities": [] + }, + { + "id": "8471", + "type": "gene", + "text": "In invertebrates , Fhit is encoded as a fusion protein with Nit , a member of the nitrilase superfamily .", + "entities": [ + "Fhit", + "Nit", + "nitrilase superfamily" + ] + }, + { + "id": "8472", + "type": "gene", + "text": "In one mechanism , a specialized ubiquitin - dependent proteolytic system ( called the APC - dependent proteolysis machinery ) degrades the mitotic ( Clb ) cyclin subunit .", + "entities": [ + "ubiquitin", + "Clb", + "cyclin subunit" + ] + }, + { + "id": "8473", + "type": "gene", + "text": "However , the promoter region contains several potential cis - regulatory elements such as Sp1 , early growth response - 1 , activator protein - 2 , MyoD , p300 , nuclear factor - kappaB , myeloid zinc finger protein - 1 , caudal - related homeobox ( Cdx ) gene A , and Cdx protein - 2 binding sites .", + "entities": [ + "Sp1", + "early growth response - 1", + "activator protein - 2", + "MyoD", + "p300", + "nuclear factor - kappaB", + "myeloid zinc finger protein - 1", + "caudal - related homeobox ( Cdx ) gene A", + "Cdx protein - 2 binding sites" + ] + }, + { + "id": "8474", + "type": "gene", + "text": "Smoking was regarded as the major contribution to pulmonary dysfunction .", + "entities": [] + }, + { + "id": "8475", + "type": "gene", + "text": "SGPT , SGOT , and alkaline phosphatase concentrations were essentially normal in all subjects .", + "entities": [ + "SGPT", + "SGOT", + "alkaline phosphatase" + ] + }, + { + "id": "8476", + "type": "gene", + "text": "Deformities of the tip of the olecranon and of the coronoid process are also described ( De Palma 1956 , Jordan 1958 , Ahlberg 1965 , Weseloh 1973 ) .", + "entities": [] + }, + { + "id": "8477", + "type": "gene", + "text": "Antidromic invasion of impulses and recurrent collateral inhibition in pyramidal tract neurones .", + "entities": [] + }, + { + "id": "8478", + "type": "gene", + "text": "IFI 16 mRNA was found to be constitutively expressed in lymphoid cells and in cell lines of both the T and B lineages .", + "entities": [ + "IFI 16 mRNA" + ] + }, + { + "id": "8479", + "type": "gene", + "text": "JNK is additionally regulated by the Ras - related G proteins Rac and Cdc42 .", + "entities": [ + "JNK", + "Ras", + "Rac", + "Cdc42" + ] + }, + { + "id": "8480", + "type": "gene", + "text": "Interestingly , addition of purified CBP to the nuclear extracts of T47D cells markedly stimulated progesterone - and PR - dependent transcription from a nucleosome - free , progesterone response element ( PRE ) - linked reporter DNA template .", + "entities": [ + "CBP", + "PR" + ] + }, + { + "id": "8481", + "type": "gene", + "text": "The data indicate that calcitonin induced a beta - endorphin increase independent of enhanced corticotrophin - cortisol release .", + "entities": [ + "calcitonin", + "beta - endorphin", + "corticotrophin" + ] + }, + { + "id": "8482", + "type": "gene", + "text": "LA - 3848 - MS .", + "entities": [] + }, + { + "id": "8483", + "type": "gene", + "text": "Two experiments investigating the effects of short - term spaceflight on cancellous bone turnover were carried out : Physiological Systems Experiment - 1 ( PSE - 1 ) ( a 4 - d orbital spaceflight ) and PSE - 2 ( a 10 - d flight ) .", + "entities": [] + }, + { + "id": "8484", + "type": "gene", + "text": "However , the presence of effacement seems to be a more reliable and practical parameter that will be preferred in that prediction .", + "entities": [] + }, + { + "id": "8485", + "type": "gene", + "text": "Cloning and expression of a specific human alpha 1 , 2 - mannosidase that trims Man9GlcNAc2 to Man8GlcNAc2 isomer B during N - glycan biosynthesis .", + "entities": [ + "human alpha 1 , 2 - mannosidase" + ] + }, + { + "id": "8486", + "type": "gene", + "text": "In vivo , selective activation of SAPKs stimulates formation of the ternary complex containing Elk - 1 , serum response factor and the serum response element , and enhances Elk - 1 - dependent transcription .", + "entities": [ + "SAPKs", + "Elk - 1", + "serum response factor", + "Elk - 1" + ] + }, + { + "id": "8487", + "type": "gene", + "text": "A phylogenetic tree of members of the T2 / S - RNase superfamily in plants was obtained .", + "entities": [ + "T2 / S - RNase superfamily" + ] + }, + { + "id": "8488", + "type": "gene", + "text": "The plasma growth hormone concentration of the foetal lamb .", + "entities": [ + "plasma growth hormone" + ] + }, + { + "id": "8489", + "type": "gene", + "text": "Deletion of the potential initiator element does not affect repression of the p21 promoter by c - Myc .", + "entities": [ + "p21 promoter", + "c - Myc" + ] + }, + { + "id": "8490", + "type": "gene", + "text": "Complexes containing wild - type and either his175 or his273 mutant p53 proteins are completely unable to bind to the RGC DNA sequence .", + "entities": [ + "his175 or his273 mutant p53 proteins", + "RGC DNA sequence" + ] + }, + { + "id": "8491", + "type": "gene", + "text": "In particular , the S1 ' specificity site is a deep and highly hydrophobic cavity .", + "entities": [ + "S1 ' specificity site" + ] + }, + { + "id": "8492", + "type": "gene", + "text": "Ab - MLV strains expressing P70 / S2 failed to transform NIH 3T3 cells and demonstrated a greatly reduced capacity to mediate signaling events associated with the Ras - dependent mitogen - activated protein ( MAP ) kinase pathway .", + "entities": [ + "P70", + "S2", + "Ras", + "mitogen - activated protein ( MAP ) kinase" + ] + }, + { + "id": "8493", + "type": "gene", + "text": "Courses were repeated every four weeks .", + "entities": [] + }, + { + "id": "8494", + "type": "gene", + "text": "A triple - mutant TBP ( R231E + R235E + R239S ) had greatly reduced activity for yeast U6 snRNA gene transcription while remaining active for Pol II basal transcription .", + "entities": [ + "triple - mutant TBP", + "yeast U6 snRNA gene", + "Pol II" + ] + }, + { + "id": "8495", + "type": "gene", + "text": "In the present experiments , we investigate the role played by the temporal pattern of neural activity during the ontogeny of frequency tuning in the mouse central auditory system .", + "entities": [] + }, + { + "id": "8496", + "type": "gene", + "text": "In all experimental eyes , there was a marked reduction , but never a complete absence of adrenergic nerves in the iris .", + "entities": [] + }, + { + "id": "8497", + "type": "gene", + "text": "The protector doubled the estimated fall distance for fracture of the trochanter .", + "entities": [] + }, + { + "id": "8498", + "type": "gene", + "text": "The role of supercritical fluid chromatography ( SFC ) as a viable technique for analyzing agricultural products has been investigated using packed and capillary column methodology .", + "entities": [] + }, + { + "id": "8499", + "type": "gene", + "text": "Large genomic constructs integrate at the endogenous locus by homologous recombination , but cDNA - derived sequences lacking long stretches of contiguous genomic DNA ( due to intron excision ) typically integrate into chromosomal DNA by nonhomologous recombination .", + "entities": [] + }, + { + "id": "8500", + "type": "gene", + "text": "Surprisingly , the CSF1R / IRDelta960 was as effective as the CSF1R / IR in mediating CSF - 1 protection of cells from staurosporine - induced apoptosis .", + "entities": [ + "CSF1R", + "IRDelta960", + "CSF1R", + "IR", + "CSF - 1" + ] + }, + { + "id": "8501", + "type": "gene", + "text": "Oxfendazole , which was active for the shortest time ( about 65 days ) from the start of grazing ( May 1 ) , produced a 78 . 1 per cent reduction in Ostertagia species and an 84 . 4 per cent reduction in D viviparus .", + "entities": [] + }, + { + "id": "8502", + "type": "gene", + "text": "Recently , a human transcription elongation factor P - TEFb , consisting of CDK9 kinase , cyclin T and other associated factors , has been shown to interact with Tat to restore Tat activation in HeLa nuclear extract depleted of P - TEFb .", + "entities": [ + "human transcription elongation factor P - TEFb", + "CDK9 kinase", + "cyclin T", + "Tat", + "Tat", + "P - TEFb" + ] + }, + { + "id": "8503", + "type": "gene", + "text": "Open head - brain injuries", + "entities": [] + }, + { + "id": "8504", + "type": "gene", + "text": "NUP145 was previously identified by using a genetic synthetic lethal screen ( E .", + "entities": [ + "NUP145" + ] + }, + { + "id": "8505", + "type": "gene", + "text": "Linear extrapolation is used below the experimental data range to establish an upper bound on carcinogenic risk at low doses .", + "entities": [] + }, + { + "id": "8506", + "type": "gene", + "text": "Plots of RV , LV + S and 2A weight vs real hematocrit showed sharp upward inflections at real hematocrit 65 % , suggesting a possible role of increased viscosity in CO cardiomegaly at the higher hematocrit .", + "entities": [] + }, + { + "id": "8507", + "type": "gene", + "text": "Multiple dosing four times daily for 7 days of indoprofen 200 mg , a non - steroidal anti - inflammatory drug with a short half - life ( t1 / 2 ) , revealed drug accumulation in eight elderly subjects .", + "entities": [] + }, + { + "id": "8508", + "type": "gene", + "text": "In a prospective , randomized clinical trial we compared the efficacy of subcutaneously ( SC ) administered ( every 8 h ) calcium heparin to intravenous ( IV ) sodium heparin in the treatment of proximal deep - vein thrombosis ( DVT ) .", + "entities": [] + }, + { + "id": "8509", + "type": "gene", + "text": "A 330 - kb YAC , A148A7 , spanned from the HLA - DQA1 locus through the Y3 / Ring 4 locus and extended at least 130 kb centromeric of YAC B1D12 .", + "entities": [ + "HLA", + "DQA1", + "Y3", + "Ring 4" + ] + }, + { + "id": "8510", + "type": "gene", + "text": "The present study highlights the improvement in sputum amoxycillin ( amoxy ) levels when a combination tablet , amoxy 500 mg plus bromhexeine 8 mg , is administered as compared to plain amoxy 500 mg .", + "entities": [] + }, + { + "id": "8511", + "type": "gene", + "text": "High - level gains ( HLGs ) indicative of gene amplifications were identified at 11q13 in two cases , and in one case each at 2q33 - 34 , 3q25 - 29 , 5p15 . 1 - 15 . 2 , 7q21 - 22 , 11p11 . 2 , 12p11 . 2 - 12 , and 13q34 .", + "entities": [] + }, + { + "id": "8512", + "type": "gene", + "text": "Band - shift assays were performed using the LPS - and IL - 1 - responsive element ( LILRE ) oligonucleotide , a gamma interferon activation site - like site that is present in the human IL - 1beta promoter .", + "entities": [ + "LPS - and IL - 1 - responsive element", + "LILRE", + "gamma interferon activation site - like site", + "human IL - 1beta promoter" + ] + }, + { + "id": "8513", + "type": "gene", + "text": "Interestingly , Csx / Nkx2 .", + "entities": [ + "Csx", + "Nkx2" + ] + }, + { + "id": "8514", + "type": "gene", + "text": "A flow rate of at least 5 mL / h is required through the receptor ( volume , 0 . 4 mL ) for accurate results .", + "entities": [] + }, + { + "id": "8515", + "type": "gene", + "text": "Data were obtained from 2 undergraduate student samples , a self - report group ( n = 132 ) who provided NEO - PI - R self - ratings on 2 occasions separated by a 7 - to 14 - day interval and an informant group ( n = 109 ) who provided ratings of well - known friends or relatives on 2 occasions separated by a 6 month interval .", + "entities": [] + }, + { + "id": "8516", + "type": "gene", + "text": "The rci gene was fused with lacZ and its gene product was identified by Western blot analysis .", + "entities": [ + "rci gene", + "lacZ" + ] + }, + { + "id": "8517", + "type": "gene", + "text": "This analysis supports the use of fluticasone propionate 88 microg twice daily as first - line treatment in patients with persistent asthma previously treated with short - acting beta2 - agonist alone .", + "entities": [ + "beta2" + ] + }, + { + "id": "8518", + "type": "gene", + "text": "The application of these instruments allows occlusion of the ascending aorta traversed by the perfusion cannula inserted directly or through the apex of the heart as well as simultaneous left ventricular venting .", + "entities": [] + }, + { + "id": "8519", + "type": "gene", + "text": "Because of this latter phenomenon , we were able to identify a particular cysteine motif that was repeated multiple times in Dfurin2 but present only twice in mammalian furin .", + "entities": [ + "Dfurin2", + "mammalian furin" + ] + }, + { + "id": "8520", + "type": "gene", + "text": "Comprising a 126 - nucleotide 5 ' untranscribed genomic sequence and a 466 - nucleotide 5 ' noncoding cDNA sequence , the 592 - nucleotide 5 ' CpG island lacked TATA and CAAT boxes but displayed a high G + C content , was enriched for CpG dinucleotides , and contained a potential Sp1 - binding site , i . e . , features compatible with a housekeeping gene .", + "entities": [ + "Sp1 - binding site" + ] + }, + { + "id": "8521", + "type": "gene", + "text": "They were checked for anti - HCV ( anti - C100 - 3 ) with HCV EIA kit ( Abbott Lab . , North Chicago , IL ) .", + "entities": [ + "anti - HCV", + "anti - C100 - 3" + ] + }, + { + "id": "8522", + "type": "gene", + "text": "We isolated the human FGF - BP promoter and determined by deletion analysis that TPA regulatory elements were all contained in the first 118 base pairs upstream of the transcription start site .", + "entities": [ + "human FGF - BP promoter" + ] + }, + { + "id": "8523", + "type": "gene", + "text": "Type IV splice pattern , containing exon U3 and S was found both in kidney and ovary .", + "entities": [] + }, + { + "id": "8524", + "type": "gene", + "text": "Using himA mutants , we confirmed that IHF plays a role in the molybdate - dependent regulation of dmsA - lacZ expression in vivo .", + "entities": [ + "himA mutants", + "IHF", + "dmsA", + "lacZ" + ] + }, + { + "id": "8525", + "type": "gene", + "text": "Nonsynonymous substitution in abalone sperm fertilization genes exceeds substitution in introns and mitochondrial DNA .", + "entities": [] + }, + { + "id": "8526", + "type": "gene", + "text": "Kinetic experiments revealed that within 10 min this radiolabeled precursor protein was converted in HL - 60 cells into an Mr approximately 150 , 000 chondroitin sulfate proteoglycan intermediate .", + "entities": [] + }, + { + "id": "8527", + "type": "gene", + "text": "Dose standardisation of botulinum toxin .", + "entities": [ + "botulinum toxin" + ] + }, + { + "id": "8528", + "type": "gene", + "text": "Diuresis was induced by scheduled drinking of tea ( 150 ml / h ) .", + "entities": [] + }, + { + "id": "8529", + "type": "gene", + "text": "Specific clotting factor assays showed an isolated deficiency of factor X ranging from 7 to 12 per cent on three determinations .", + "entities": [ + "factor X" + ] + }, + { + "id": "8530", + "type": "gene", + "text": "Although a great deal is understood about how bHLH factors activate gene transcription via E - box DNA consensus sequences , studies of bHLH factor function in higher eukaryotes often have been hindered by the presence of multiple family members .", + "entities": [ + "bHLH factors", + "bHLH factor" + ] + }, + { + "id": "8531", + "type": "gene", + "text": "To determine if CYC2 is found in a complex with previously identified trypanosome cdc2 - related kinases ( CRKs ) , the CYC2 gene was fused to the TY epitope tag , integrated into the trypanosome genome , and expressed under inducible control .", + "entities": [ + "CYC2", + "trypanosome cdc2 - related kinases", + "CRKs", + "CYC2 gene", + "TY epitope" + ] + }, + { + "id": "8532", + "type": "gene", + "text": "This region is required for activation of DNA binding of MyoD and E12 homodimers and E12 / MyoD heterodimers .", + "entities": [ + "MyoD", + "E12 homodimers", + "E12", + "MyoD" + ] + }, + { + "id": "8533", + "type": "gene", + "text": "Administration of a second dose of vaccine during the outbreak was not protective .", + "entities": [] + }, + { + "id": "8534", + "type": "gene", + "text": "By contrast , their basal adrenal androgen levels were significantly decreased compared to those in normal subjects on both the day on and the day off prednisone ( P less than 0 . 05 ) .", + "entities": [] + }, + { + "id": "8535", + "type": "gene", + "text": "Using immunolocalization , we observe that ACE3 , a 440 - bp chorion element that contains information sufficient to drive amplification , directs DmORC localization in follicle cells .", + "entities": [ + "ACE3", + "DmORC" + ] + }, + { + "id": "8536", + "type": "gene", + "text": "S . , K .", + "entities": [] + }, + { + "id": "8537", + "type": "gene", + "text": "DNA - binding activity was not increased by the addition of forskolin to thecal or luteal cells .", + "entities": [] + }, + { + "id": "8538", + "type": "gene", + "text": "( Emeritus ) John Henri Roosegaarde Bisschop", + "entities": [] + }, + { + "id": "8539", + "type": "gene", + "text": "Legionella , microbial ecology , and inconspicuous consumption .", + "entities": [] + }, + { + "id": "8540", + "type": "gene", + "text": "In this report , we present two lines of evidence that all ribosomes which synthesize GCN4 have previously translated uORF1 , resumed scanning , and reinitiated at the GCN4 start site .", + "entities": [ + "GCN4", + "GCN4" + ] + }, + { + "id": "8541", + "type": "gene", + "text": "Whole bowel irrigation is a recently described technique to enhance the passage of drugs already beyond the pylorus .", + "entities": [] + }, + { + "id": "8542", + "type": "gene", + "text": "This suggests that helicase - like genes may be involved in the biosynthesis of nucleic acids and proteins , and that the genes can be transcriptionally activated by heat shock to compensate for the repressed synthesis of mRNA and protein .", + "entities": [ + "helicase - like genes" + ] + }, + { + "id": "8543", + "type": "gene", + "text": "Hybridization of plasmid - transformed Escherichia coli RR1 colonies with 32P - labeled viral genome RNAs demonstrated the presence of DNA clones representative of each of the 10 reovirus RNAs and 10 of the 11 constituent segments of the rotavirus genome .", + "entities": [] + }, + { + "id": "8544", + "type": "gene", + "text": "Two related cDNAs were isolated that encode proteins that recognize the XMyoDa TATA motif .", + "entities": [ + "XMyoDa TATA motif" + ] + }, + { + "id": "8545", + "type": "gene", + "text": "In a similar fashion to adipose stromal cells , serum potentiated the response to dexamethasone but had no effect on phorbol ester - stimulated activity .", + "entities": [] + }, + { + "id": "8546", + "type": "gene", + "text": "The mouse beta 2 - syntrophin gene ( > 33 kilobases ) contains seven exons , all of which have homologues at the corresponding position in the alpha 1 - syntrophin gene .", + "entities": [ + "mouse beta 2 - syntrophin gene", + "alpha 1 - syntrophin gene" + ] + }, + { + "id": "8547", + "type": "gene", + "text": "Problems in the determination of the antigenic content of influenza vaccines .", + "entities": [] + }, + { + "id": "8548", + "type": "gene", + "text": "Re - evaluation of the biopsy specimen from the right hip taken at the time of the initial operation showed areas of chondrosarcoma arising in the background of synovial chondromatosis .", + "entities": [] + }, + { + "id": "8549", + "type": "gene", + "text": "The hcKrox gene family regulates multiple extracellular matrix genes .", + "entities": [ + "hcKrox" + ] + }, + { + "id": "8550", + "type": "gene", + "text": "This exon , here named exon 0 , contained the entire 5 ' untranslated region and the N - terminal signal sequence of the polypeptide .", + "entities": [] + }, + { + "id": "8551", + "type": "gene", + "text": "Atmospheric benzene , urinary muconic acid ( tt - MA ) and leukocyte alkaline phosphatase activity ( LAPA ) were evaluated among 66 car mechanics , 34 road tanker drivers , and 28 nonexposed workers .", + "entities": [ + "leukocyte alkaline phosphatase" + ] + }, + { + "id": "8552", + "type": "gene", + "text": "Deletion analyses of the construct revealed that the transcription of BOXF1 gene is regulated by BOX DNA , preferentially in undifferentiated EC cells versus differentiated cells .", + "entities": [ + "BOXF1 gene" + ] + }, + { + "id": "8553", + "type": "gene", + "text": "A .", + "entities": [] + }, + { + "id": "8554", + "type": "gene", + "text": "KFC , a Ste20 - like kinase with mitogenic potential and capability to activate the SAPK / JNK pathway .", + "entities": [ + "KFC", + "Ste20 - like kinase", + "SAPK", + "JNK" + ] + }, + { + "id": "8555", + "type": "gene", + "text": "Cytoprotection with amifostine in radiotherapy or radio - chemotherapy of head and neck tumors", + "entities": [] + }, + { + "id": "8556", + "type": "gene", + "text": "Exons A1a and A1b are separated from each other by a 124 - nucleotide intron .", + "entities": [] + }, + { + "id": "8557", + "type": "gene", + "text": "The half - life of the serum - induced CBP / tk binding activity was estimated to be less than 1 h . ( ABSTRACT TRUNCATED AT 400 WORDS )", + "entities": [ + "CBP", + "tk" + ] + }, + { + "id": "8558", + "type": "gene", + "text": "Measurement of open - loop responses to electrical stimulation in olfactory bulb of cat .", + "entities": [] + }, + { + "id": "8559", + "type": "gene", + "text": "The dynamic properties of this protein fragment were measured and analyzed using both isotropic and anisotropic models of molecular motion .", + "entities": [] + }, + { + "id": "8560", + "type": "gene", + "text": "Franz Schubert - - his life , music and diseases", + "entities": [] + }, + { + "id": "8561", + "type": "gene", + "text": "This suggested that delta 6 and delta 5 desaturation activities are normal in these conditions with this C18 : 2w6 supply .", + "entities": [] + }, + { + "id": "8562", + "type": "gene", + "text": "Biopsies of the jejunal mucosa have shown abnormal enzyme activity or deficiencies in transport mechanisms .", + "entities": [] + }, + { + "id": "8563", + "type": "gene", + "text": "Thus , these studies indicate that the 104 - kDa isoform is required for normal proliferation of female germline cells and perhaps for oocyte differentiation .", + "entities": [] + }, + { + "id": "8564", + "type": "gene", + "text": "Oligodeoxynucleotides antisense to the predicted translation initiation regions of ICP4 and pp38 mRNAs inhibited proliferation of MSB1 cells but not MDCC - CU91 ( CU91 ) reticuloendotheliosis virus - transformed cells .", + "entities": [ + "ICP4", + "pp38 mRNAs" + ] + }, + { + "id": "8565", + "type": "gene", + "text": "A second aim was to determine whether the decrease in muscle - tendon unit rest length produced by prolonged immobilisation in a shortened position is mediated primarily by adaptations of the muscle or tendon .", + "entities": [] + }, + { + "id": "8566", + "type": "gene", + "text": "Inhibition appears to result from titration of general transcription factors because MDM2 overexpression inhibits c - fos as well as other promoters in vivo and basal transcription in vitro .", + "entities": [ + "MDM2", + "c - fos" + ] + }, + { + "id": "8567", + "type": "gene", + "text": "Cases of lung cancer with intramedullary metastasis are rare , especially those diagnosed before death .", + "entities": [] + }, + { + "id": "8568", + "type": "gene", + "text": "Seven patients ( 8 . 3 percent ) had latent hypothyroidism only discovered by hormonal determinations .", + "entities": [] + }, + { + "id": "8569", + "type": "gene", + "text": "Furthermore , MOM - 4 and TAK1 bind related proteins that promote their kinase activities .", + "entities": [ + "MOM - 4", + "TAK1" + ] + }, + { + "id": "8570", + "type": "gene", + "text": "DNase I footprinting analysis indicated that DREF binds to the 24 - bp DRE region of the DNA polymerase alpha gene in which 8 - bp palindromic sequences are centered .", + "entities": [ + "DNase I", + "DREF", + "DNA polymerase alpha gene" + ] + }, + { + "id": "8571", + "type": "gene", + "text": "Both PPC - 1 and ALVA - 31 cells display tumorigenesis and invasiveness in nude mice , whereas LNCap cells exhibit a less malignant phenotype , suggesting a correlation between CD44 variant ( CD44v ) expression and aggressive prostate tumor behavior .", + "entities": [ + "CD44 variant", + "CD44v" + ] + }, + { + "id": "8572", + "type": "gene", + "text": "Doxorubicin , dacarbazine , vincristine , and cyclophosphamide in the treatment of advanced gastrointestinal leiomyosarcoma .", + "entities": [] + }, + { + "id": "8573", + "type": "gene", + "text": "Multizone PRK has been suggested to increase the predictability of higher myopic corrections .", + "entities": [] + }, + { + "id": "8574", + "type": "gene", + "text": "Dorsal root ganglia neuron - specific promoter activity of the rabbit beta - galactoside alpha1 , 2 - fucosyltransferase gene .", + "entities": [ + "rabbit beta - galactoside alpha1 , 2 - fucosyltransferase gene" + ] + }, + { + "id": "8575", + "type": "gene", + "text": "DATA SOURCES : Epidemiologic studies , research studies , review articles , and government reports pertaining to epidemiology of lung cancer .", + "entities": [] + }, + { + "id": "8576", + "type": "gene", + "text": "Similar results were also obtained with a HepG2 hepatoblastoma cell line carrying wt p53 .", + "entities": [ + "wt p53" + ] + }, + { + "id": "8577", + "type": "gene", + "text": "Vitamin D3 and calcium absorption in the chick .", + "entities": [] + }, + { + "id": "8578", + "type": "gene", + "text": "Furthermore , the identification of a Dr1 - like protein in A . thaliana strongly argues for the ubiquity of this protein among eukaryotic genera and for a conserved mechanism to regulate transcription initiation that involves Dr1 .", + "entities": [ + "Dr1 - like protein", + "Dr1" + ] + }, + { + "id": "8579", + "type": "gene", + "text": "The exodomain alone has the high affinity hormone binding site but is not capable of generating hormonal signal .", + "entities": [] + }, + { + "id": "8580", + "type": "gene", + "text": "The accumulated products of ancient duplication events can be readily observed among the genes encoding voltage - dependent Ca ( 2 + ) ion channels .", + "entities": [] + }, + { + "id": "8581", + "type": "gene", + "text": "It was possible to classify the animals into high and low responders according to the pattern of humoral immune response .", + "entities": [] + }, + { + "id": "8582", + "type": "gene", + "text": "We report the isolation of genomic and cDNA clones of the light - independent Sn : bol3 allele .", + "entities": [ + "Sn : bol3 allele" + ] + }, + { + "id": "8583", + "type": "gene", + "text": "Of 848 patients , 819 cases with complete description of patient ' s background were evaluable : Group A ( surgery + MMC + 5 - FU : chemotherapy ) 253 cases , group B ( surgery + MMC + 5 - FU + OK - 432 or PSK : immunochemotherapy ) 282 and group C ( surgery alone ) 284 .", + "entities": [] + }, + { + "id": "8584", + "type": "gene", + "text": "This gave rise to RNA molecules with 3 ' - untranslated regions of roughly 375 , 655 , and 945 base pairs .", + "entities": [] + }, + { + "id": "8585", + "type": "gene", + "text": "Serodiagnosis of trypanosomiasis in dromedary camels using a card agglutination test set ( Testryp CATT ) .", + "entities": [] + }, + { + "id": "8586", + "type": "gene", + "text": "Pyk2 phosphorylation increased upon adherence of FLG 29 . 1 cells to fibronectin and to ST2 stromal cells .", + "entities": [ + "Pyk2", + "fibronectin" + ] + }, + { + "id": "8587", + "type": "gene", + "text": "No significant differences were found in relation to Type A behaviour and beta - adrenoceptor blockade .", + "entities": [ + "beta - adrenoceptor" + ] + }, + { + "id": "8588", + "type": "gene", + "text": "Electronic structure of delta - plutonium and of single Al , Ga , and Sc impurities in delta - plutonium .", + "entities": [] + }, + { + "id": "8589", + "type": "gene", + "text": "The cloned genes were identified in genetic libraries by hybridization screening using four deoxyoligonucleotide probes which corresponded to the partial amino acid sequence of the purified enzyme .", + "entities": [] + }, + { + "id": "8590", + "type": "gene", + "text": "Ex vivo MAO inhibition data indicated DPGPEA to be an inhibitor of MAO - B , although the effect was much weaker than seen with tranylcypromine or pargyline .", + "entities": [ + "MAO", + "MAO - B" + ] + }, + { + "id": "8591", + "type": "gene", + "text": "Multifunctional protein kinase ( MFPK ) phosphorylates ATP - citrate lyase on peptide B on two sites , BT and BS , on threonine and serine , respectively , inhibitor 2 on a threonyl residue , and glycogen synthase at sites 2 and 3 .", + "entities": [ + "Multifunctional protein kinase", + "MFPK", + "ATP - citrate lyase", + "peptide B", + "inhibitor 2", + "glycogen synthase" + ] + }, + { + "id": "8592", + "type": "gene", + "text": "This distribution parallels that of the neurotransmitters glutamate and aspartate ; however , neither of these excitatory amino acids is a substrate for transport .", + "entities": [] + }, + { + "id": "8593", + "type": "gene", + "text": "Domain switch experiments reveal that C / EBP beta proteins containing either the leucine zipper or the activation domain of C / EBP alpha are unable to stimulate the 2D5 promoter yet are fully capable of transactivating an artificial promoter bearing a high - affinity C / EBP site .", + "entities": [ + "C / EBP beta proteins", + "C / EBP alpha", + "2D5 promoter", + "C / EBP site" + ] + }, + { + "id": "8594", + "type": "gene", + "text": "These \" nucleocapsid - like \" structures were readily purified by density gradient centrifugation .", + "entities": [] + }, + { + "id": "8595", + "type": "gene", + "text": "A total of 7 ( 4 males and 3 females ) patients were included in this retrospective study to determine the sensitivity of radioimmunoscintigraphy with I - 131 labeled anti CEA / CA 19 - 9 monoclonal antibodies .", + "entities": [ + "anti CEA", + "CA 19 - 9" + ] + }, + { + "id": "8596", + "type": "gene", + "text": "Poly ( dT ) and denatured calf thymus DNA were more effective than were other polynucleotides tested in promoting accumulation of 19 HDP * ; ( dT ) 8 was as effective as were longer molecules of ( dT ) n , but ( dT ) 4 and ( dT ) 6 were much less effective , indicating that the binding site involved in 19 HDP * accumulation covered between 6 and 8 residues of ( dT ) n .", + "entities": [ + "HDP *", + "HDP *" + ] + }, + { + "id": "8597", + "type": "gene", + "text": "The human papillomavirus type 16 E7 protein complements adenovirus type 5 E1A amino - terminus - dependent transactivation of adenovirus type 5 early genes and increases ATF and Oct - 1 DNA binding activity .", + "entities": [ + "human papillomavirus type 16 E7 protein", + "adenovirus type 5 E1A", + "adenovirus type 5 early genes", + "ATF", + "Oct - 1" + ] + }, + { + "id": "8598", + "type": "gene", + "text": "The heterogeneity of bovine IgG2 - - VIII .", + "entities": [ + "bovine IgG2 - - VIII" + ] + }, + { + "id": "8599", + "type": "gene", + "text": "These results suggest that FK 506 is a useful immunosuppressive agent in kidney transplantation .", + "entities": [] + }, + { + "id": "8600", + "type": "gene", + "text": "These results indicate that T . C . , LDL - C . , HDL - C . , HDL2 - C . , apo B , apo A - I / B ratio and apo A - II / B ratio are predictive risk factors of the coronary heart disease .", + "entities": [ + "LDL - C", + "HDL - C", + "HDL2 - C", + "apo B", + "apo A - I / B", + "apo A - II / B" + ] + }, + { + "id": "8601", + "type": "gene", + "text": "In particular , the highly expressed ADH1 gene is represented in this database by no less than 20 EST sequences .", + "entities": [ + "ADH1 gene" + ] + }, + { + "id": "8602", + "type": "gene", + "text": "Using transgenic Xenopus embryos , we demonstrate that the integrity of these two sequences is necessary for correct spatial expression of a Xbra2 promoter - driven reporter gene .", + "entities": [ + "Xbra2 promoter - driven reporter gene" + ] + }, + { + "id": "8603", + "type": "gene", + "text": "Peripheral vitreochorioretinal dystrophies in myopia patients", + "entities": [] + }, + { + "id": "8604", + "type": "gene", + "text": "Characterization of the 5 ' end of the growth - regulated Syrian hamster CAD gene .", + "entities": [ + "Syrian hamster CAD gene" + ] + }, + { + "id": "8605", + "type": "gene", + "text": "Recombinant FVIIa was stable in the infusion pump for several days at room temperature and for 24 h at body temperature .", + "entities": [ + "Recombinant FVIIa" + ] + }, + { + "id": "8606", + "type": "gene", + "text": "IV .", + "entities": [] + }, + { + "id": "8607", + "type": "gene", + "text": "Like their yeast counterpart , the mouse GCN2 isoforms contain HisRS - related sequences juxtaposed to the kinase catalytic domain .", + "entities": [ + "GCN2", + "HisRS - related sequences" + ] + }, + { + "id": "8608", + "type": "gene", + "text": "The highest postoperative CK - MB level was less after BC ( BC , 31 + / - 17 U / L ; CC , 56 + / - 13 U / L ; p less than 0 . 05 ) .", + "entities": [ + "CK - MB" + ] + }, + { + "id": "8609", + "type": "gene", + "text": "Quantitative assays in which the activity of the synthetic alpha s - 1 was compared to that of native purified human erythrocyte type - 1 Gs , indicated that the two products are equipotent within a 2 - fold margin of error .", + "entities": [ + "synthetic alpha s - 1", + "human erythrocyte type - 1 Gs" + ] + }, + { + "id": "8610", + "type": "gene", + "text": "High concentrations of tumor - associated trypsin inhibitor in hemodialyzed patients .", + "entities": [ + "trypsin" + ] + }, + { + "id": "8611", + "type": "gene", + "text": "Thirty isolates of Haemophilus influenzae type b were obtained during an outbreak of invasive H . influenzae type b disease and were classified by the electrophoretic profile of their lipopolysaccharide ( LPS ) .", + "entities": [] + }, + { + "id": "8612", + "type": "gene", + "text": "A progressive growth of blood erythrocyte membrane injury has been demonstrated after rats were exposed to gamma - irradiaton at a dose of 100 to 500 Gy .", + "entities": [] + }, + { + "id": "8613", + "type": "gene", + "text": "Sixty months after the initial vaccination , all vaccinees who received annual follow - up still had protective levels of anti - HAV .", + "entities": [ + "anti - HAV" + ] + }, + { + "id": "8614", + "type": "gene", + "text": "The mucosal defence capacity against proteolytic leukocyte enzymes .", + "entities": [] + }, + { + "id": "8615", + "type": "gene", + "text": "Mutations in either gene block some crucial late step in assembly of F1 , causing the alpha and beta subunits to accumulate in mitochondria as inactive aggregates ( Ackerman , S .", + "entities": [ + "F1" + ] + }, + { + "id": "8616", + "type": "gene", + "text": "Hybrid - selection experiments against total PB - inducible RNA were performed with plasmid DNA derived from clones enriched in PB - inducible information .", + "entities": [] + }, + { + "id": "8617", + "type": "gene", + "text": "Secondary cleavage of RT at Trp - 595 - Tyr - 596 of Pol yields a truncated form lacking the C - terminal RNase H domain .", + "entities": [ + "RT", + "Pol", + "C - terminal RNase H domain" + ] + }, + { + "id": "8618", + "type": "gene", + "text": "The experimentally mapped regions of RPB5 involved in these interactions correspond to distinct and surface - exposed alpha - helical structures .", + "entities": [ + "RPB5" + ] + }, + { + "id": "8619", + "type": "gene", + "text": "A method is described for the simultaneous determination of 1 , alpha - acetylmethadol ( LAAM ) and five active metabolites - - noracetylmethadol , dinoracetylmethadol , methadol , normethadol , and dinormethadol - - in biofluids by high - performance liquid chromatography using a normal - phase column and a UV detector at 218 nm .", + "entities": [] + }, + { + "id": "8620", + "type": "gene", + "text": "During IC breaths and following EC and VC breaths at rest , end - tidal CO2 pressure ( PET , CO2 ) fell by 7 . 5 , 8 . 5 and 9 . 5 mmHg , respectively .", + "entities": [] + }, + { + "id": "8621", + "type": "gene", + "text": "All patients had elevated levels of serum IgE antibodies to the crude soybean extract ; binding values ranged from 2 . 3 to 28 . 1 times that of a negative control serum .", + "entities": [ + "serum IgE antibodies" + ] + }, + { + "id": "8622", + "type": "gene", + "text": "This study examines the effects of hypovolemia on the extracellular ptO2 and ptH distributions at multiple tissue sites using a recently developed multipoint microelectrode , that provides simultaneous measurements of ptO2 and ptH .", + "entities": [] + }, + { + "id": "8623", + "type": "gene", + "text": "A subset of patients ( n = 30 ) underwent multichannel pressure flow studies , which demonstrated that transrectal HIFU reduces bladder outflow obstruction .", + "entities": [] + }, + { + "id": "8624", + "type": "gene", + "text": "These effects were abrogated by co - expression of kinase - deficient PKC zeta and inhibition of phosphatidylinositol 3 - kinase p85alpha - p110 by wortmannin , LY294002 and a dominant - negative mutant of p85alpha .", + "entities": [ + "kinase - deficient PKC zeta", + "p85alpha", + "p110", + "p85alpha" + ] + }, + { + "id": "8625", + "type": "gene", + "text": "Innervation of the ventral diaphragm of the locust ( Locusta migratoria ) .", + "entities": [] + }, + { + "id": "8626", + "type": "gene", + "text": "ECP and tryptase levels in serum were measured before and after the last oral challenge .", + "entities": [ + "ECP", + "tryptase" + ] + }, + { + "id": "8627", + "type": "gene", + "text": "Sodium polystyrene sulfonate treatment for lithium toxicity : effects on serum potassium concentrations .", + "entities": [] + }, + { + "id": "8628", + "type": "gene", + "text": "Gap1 ( IP4BP ) , one of a member of Ras GTPase - activating proteins , has been identified as a specific inositol 1 , 3 , 4 , 5 - tetrakisphosphate ( IP4 ) - binding protein ( Cullen , P .", + "entities": [ + "Gap1 ( IP4BP )", + "Ras GTPase - activating proteins", + "inositol 1 , 3 , 4 , 5 - tetrakisphosphate ( IP4 ) - binding protein" + ] + }, + { + "id": "8629", + "type": "gene", + "text": "Site - directed mutagenesis showed that two adjacent SP1 sites proximal to exon 1 were equally important in sustaining basal promoter activity .", + "entities": [ + "SP1 sites" + ] + }, + { + "id": "8630", + "type": "gene", + "text": "RESULTS : The target dose was comparable in the 3D - CRT and IMRT plans , although improvements were seen when seven and nine IMRT fields were used .", + "entities": [] + }, + { + "id": "8631", + "type": "gene", + "text": "Diacylglycerol kinase ( DGK ) attenuates levels of second messenger diacylglycerol in cells and produces another ( putative ) messenger , phosphatidic acid .", + "entities": [ + "Diacylglycerol kinase", + "DGK" + ] + }, + { + "id": "8632", + "type": "gene", + "text": "Characterization of the regulatory regions of the human aromatase ( P450arom ) gene involved in placenta - specific expression .", + "entities": [ + "human aromatase", + "P450arom" + ] + }, + { + "id": "8633", + "type": "gene", + "text": "Intravenous injections of SG - 75 ( 0 . 03 - 1 mg / kg ) decreased systemic blood pressure ( SBP ) and increased peripheral ( coronary , renal , mesenteric and femoral ) blood flow ( PBF ) dose - dependently .", + "entities": [] + }, + { + "id": "8634", + "type": "gene", + "text": "Basal FSH and LH levels were significantly lower in addicts ; after GnRH stimulation the addicts ' FSH and LH values increased but not significantly compared to controls .", + "entities": [ + "FSH", + "LH", + "GnRH", + "FSH", + "LH" + ] + }, + { + "id": "8635", + "type": "gene", + "text": "The transforming gene of the avian sarcoma virus CT10 encodes a fusion protein ( p47gag - crk or v - Crk ) containing viral Gag sequences fused to cellular sequences consisting primarily of Src homology regions 2 and 3 ( SH2 and SH3 sequences ) .", + "entities": [ + "avian sarcoma virus CT10", + "p47gag", + "crk", + "v - Crk", + "viral Gag sequences", + "Src homology regions 2 and 3", + "SH2", + "SH3 sequences" + ] + }, + { + "id": "8636", + "type": "gene", + "text": "Comparison of three different preparations of disodium cromoglycate in the prevention of exercise - induced bronchospasm : a double - blind study .", + "entities": [] + }, + { + "id": "8637", + "type": "gene", + "text": "The effect of water deprivation for 19 h on renal Na excretion of conscious adrenalectomized ( ADX ) sheep maintained on a constant intravenous infusion of aldosterone and cortisol ( ADX - constant steroid sheep ) was investigated .", + "entities": [] + }, + { + "id": "8638", + "type": "gene", + "text": "Similar to Hp140 , isolated Hp55 binds DNA with moderate strength and was a specificity for double - stranded primer - template DNA .", + "entities": [ + "Hp140", + "Hp55" + ] + }, + { + "id": "8639", + "type": "gene", + "text": "BRCA1 protein contains an amino - terminal zinc finger motif and a carboxy - terminal acidic region .", + "entities": [ + "BRCA1 protein" + ] + }, + { + "id": "8640", + "type": "gene", + "text": "Since we have observed effects of growth factors and cAMP as well as estradiol ( E2 ) on regulation of expression of some genes stimulated by the estrogen receptor ( ER ) , we have undertaken studies to examine directly whether activators of protein kinases can modulate transcriptional activity of the ER .", + "entities": [ + "estrogen receptor", + "ER", + "ER" + ] + }, + { + "id": "8641", + "type": "gene", + "text": "During the aftermath of excitation of the skin sympathetic nerve by mental arithmetics , 3 / 12 A delta units were turned to the active state with decreased mechanical threshold .", + "entities": [] + }, + { + "id": "8642", + "type": "gene", + "text": "CONCLUSION : Extrusion cooking is effective for the inactivation of DON but is of limited value for AFB1 , even if metabisulphite is added .", + "entities": [ + "AFB1" + ] + }, + { + "id": "8643", + "type": "gene", + "text": "Significant correlations existed between FEV1 and the corresponding values of Raw , MEF50 and MEF25 , although there were considerable individual differences between test results .", + "entities": [] + }, + { + "id": "8644", + "type": "gene", + "text": "The pathogenicity of Achromobacter puntatum for cold blooded and warm blooded animals", + "entities": [] + }, + { + "id": "8645", + "type": "gene", + "text": "Effect of corticosteroid - containing antirheumatic combination drugs on endogenous ACTH and cortisol production .", + "entities": [ + "ACTH" + ] + }, + { + "id": "8646", + "type": "gene", + "text": "Chaotic electron dynamics around a single elliptically shaped antidot .", + "entities": [] + }, + { + "id": "8647", + "type": "gene", + "text": "We have determined that the mutants define two complementation groups , designated cgs1 + and cgs2 + ( continues to grow in stationary ) .", + "entities": [ + "cgs1 +", + "cgs2 +" + ] + }, + { + "id": "8648", + "type": "gene", + "text": "81 milk samples collected from 35 donors 3 days to 7 months after delivery were examined for the occurrence of cytomegalovirus ( CMV ) .", + "entities": [] + }, + { + "id": "8649", + "type": "gene", + "text": "Reaction times to tachistoscopically presented stimuli in diabetics", + "entities": [] + }, + { + "id": "8650", + "type": "gene", + "text": "Dermal toxicity and carcinogenicity of 4 - vinyl - 1 - cyclohexene diepoxide in Fischer rats and B6C3F1 mice .", + "entities": [] + }, + { + "id": "8651", + "type": "gene", + "text": "We have found out that one - year - old carps are extremely sensitive to ichthiomycin in concentrations between 25 - 125 micrograms / dm3 .", + "entities": [] + }, + { + "id": "8652", + "type": "gene", + "text": "The factor designated B formed a complex centered on the sequence TGTGGT , a core motif recognized by members of the AML / CBFalpha transcription factor family .", + "entities": [ + "AML / CBFalpha transcription factor family" + ] + }, + { + "id": "8653", + "type": "gene", + "text": "Linking continuous community - based morbidity recording of influenza - like illness ( ILI ) with virological sampling has consistently proved its value as one of the earliest indicators of circulating influenza activity .", + "entities": [] + }, + { + "id": "8654", + "type": "gene", + "text": "By 150 minutes after Cr2O3 inhalation , FEV1 . 0 had decreased by 32 % .", + "entities": [] + }, + { + "id": "8655", + "type": "gene", + "text": "The Og4C3 enzyme - linked immunosorbent assay ( ELISA ) to detect circulating Wuchereria bancrofti antigen uses 50 microL of serum .", + "entities": [ + "Og4C3", + "Wuchereria bancrofti antigen" + ] + }, + { + "id": "8656", + "type": "gene", + "text": "Using a v - erbA probe , we obtained a cDNA which encodes a novel 445 - amino - acid protein , RLD - 1 , that contains the characteristic domains of nuclear receptors .", + "entities": [ + "v - erbA", + "RLD - 1" + ] + }, + { + "id": "8657", + "type": "gene", + "text": "In the posthospital phase of AMI , as well as in CCHD , the occurrence of high - grade VPBs usually indicates more advanced degrees of both coronary and left ventricular disease as well as the possibility of cardiac and / or sudden death .", + "entities": [] + }, + { + "id": "8658", + "type": "gene", + "text": "These sites are also potential keratan sulfate attachment sites .", + "entities": [] + }, + { + "id": "8659", + "type": "gene", + "text": "Upstream from the transcription start point ( tsp ) , a nucleotide sequence highly homologous to the consensus sequence motif for the sigma 35 - recognized promoters was found .", + "entities": [ + "consensus sequence motif for the sigma 35 - recognized promoters" + ] + }, + { + "id": "8660", + "type": "gene", + "text": "Molecular and functional characterization of the promoter of ETS2 , the human c - ets - 2 gene .", + "entities": [ + "ETS2", + "c - ets - 2" + ] + }, + { + "id": "8661", + "type": "gene", + "text": "Chlorambucil and interferon for low grade non - Hodgkin ' s lymphoma .", + "entities": [ + "interferon" + ] + }, + { + "id": "8662", + "type": "gene", + "text": "Thus , the multidomained ROK alpha appears to be involved in reorganization of the cytoskeleton , with the N and C termini acting as positive and negative regulators , respectively , of the kinase domain whose activity is crucial for formation of stress fibers and focal adhesion complexes .", + "entities": [ + "ROK alpha" + ] + }, + { + "id": "8663", + "type": "gene", + "text": "Autotransplantation of a vein segment with valve in the treatment of deep vein valvular insufficiency of the lower extremity", + "entities": [] + }, + { + "id": "8664", + "type": "gene", + "text": "In the DNA recognition helix of finger II , the conserved Arg at position 62 ( N - terminal side of the first zinc - coordinating histidine ) was changed to a Leu or Gln .", + "entities": [] + }, + { + "id": "8665", + "type": "gene", + "text": "One of its unique features appears to be the unusually short 5 ' - untranslated regions ( UTR ) ( 1 - 6 nucleotides ( nts ) ) and the apparent absence of 5 ' - cap structures from its mRNAs .", + "entities": [] + }, + { + "id": "8666", + "type": "gene", + "text": "With a population of 853 million there should be 51 , 204 patients with hemophilia A in India assuming a prevalence of 6 / 100 , 000 population .", + "entities": [] + }, + { + "id": "8667", + "type": "gene", + "text": "The stereoselectivity of drug action .", + "entities": [] + }, + { + "id": "8668", + "type": "gene", + "text": "Both 4 , 8 - DiMeIQx and A alpha C were found at < 1 p . p . b .", + "entities": [] + }, + { + "id": "8669", + "type": "gene", + "text": "To identify the DNA sequences that cis - regulate the expression of the rat liver pyruvate kinase ( L - PK ) genes , a series of constructs in which the chloramphenicol acetyltransferase reporter genes is driven by various deleted fragments of the 3200 base pairs ( bp ) upstream of the L - PK gene cap site have been assayed for transient expression after introduction into hepatoma HepG2 cells , rat hepatocytes in primary culture , fibroblast LTK - cells , myogenic C2C12 cells , and CHO cells .", + "entities": [ + "rat liver pyruvate kinase", + "L - PK", + "chloramphenicol acetyltransferase reporter genes", + "L - PK gene cap site" + ] + }, + { + "id": "8670", + "type": "gene", + "text": "Defective provirus genomes of human T - cell leukemia virus type I are frequently detected in lymphocytes from infected individuals and in infected cell lines .", + "entities": [] + }, + { + "id": "8671", + "type": "gene", + "text": "Following chondroitinase AC and ABC digestion , staining reactions suggested that the highest levels of dermatan sulfate were in the diabetes resistant group ( p less than 0 . 001 compared to diabetic , p less than 0 . 001 compared to diabetes prone ) and the highest levels of chondroitin sulfates were in the diabetes prone group ( p less than 0 . 001 ) .", + "entities": [ + "chondroitinase AC and ABC" + ] + }, + { + "id": "8672", + "type": "gene", + "text": "During heat exposure , chicks that had been subjected to early 60 % restriction with non - metyrapone - treated food had lower H / L ratios and improved resistance to marble spleen disease infection .", + "entities": [] + }, + { + "id": "8673", + "type": "gene", + "text": "The ubiquitously expressed hypoxia - inducible factor - 1 ( HIF - 1 ) is involved in expression of a large number of oxygen - regulated genes .", + "entities": [ + "hypoxia - inducible factor - 1", + "HIF - 1" + ] + }, + { + "id": "8674", + "type": "gene", + "text": "Competitive reverse transcription - polymerase chain reaction and HPLC analysis showed that RUSH - 1alpha is the progesterone - dependent splice variant .", + "entities": [ + "RUSH - 1alpha" + ] + }, + { + "id": "8675", + "type": "gene", + "text": "We inserted genes or gene segments , that code for the bacterial chloramphenicol acetyltransferase , the bacterial gene conferring resistance against hygromycin , and the ORF E7 of the human papillomavirus type 18 into these vectors .", + "entities": [ + "bacterial chloramphenicol acetyltransferase", + "E7" + ] + }, + { + "id": "8676", + "type": "gene", + "text": "In conclusion , primary chemotherapy based on high dose MTX and ara - C is highly efficient in PCNSL .", + "entities": [] + }, + { + "id": "8677", + "type": "gene", + "text": "Western blot analysis showed a rapid corresponding increase in p21WAF1 / CIP1 protein , whereas protein levels of another member of the cyclin - dependent kinase inhibitor family , p27kip1 , were unchanged .", + "entities": [ + "p21WAF1", + "CIP1", + "cyclin - dependent kinase inhibitor family", + "p27kip1" + ] + }, + { + "id": "8678", + "type": "gene", + "text": "We report here that , for a constant amount of transfected DNA , the level of chloramphenicol acetyltransferase ( CAT ) mRNA is increased in Vpr - expressing cells using either HIV - 1 or a murine leukemia virus ( MLV ) SL3 - 3 LTR - CAT reporter construct .", + "entities": [ + "chloramphenicol acetyltransferase", + "CAT", + "Vpr", + "leukemia virus ( MLV ) SL3 - 3 LTR", + "CAT" + ] + }, + { + "id": "8679", + "type": "gene", + "text": "Relation between mixing ratio of raw materials and composition of products in the synthesis of aluminosilicates", + "entities": [] + }, + { + "id": "8680", + "type": "gene", + "text": "A brief discussion of color deficiencies .", + "entities": [] + }, + { + "id": "8681", + "type": "gene", + "text": "Transcriptional regulation of SUP35 and SUP45 in Saccharomyces cerevisiae .", + "entities": [ + "SUP35", + "SUP45 in Saccharomyces cerevisiae" + ] + }, + { + "id": "8682", + "type": "gene", + "text": "METHODS : Humphrey Field Analyzer model 630 ( HFA I , program 30 - 2 with a rectangular 6 degrees x 6 degrees grid ) was used as the conventional perimetric method .", + "entities": [] + }, + { + "id": "8683", + "type": "gene", + "text": "Salzburg , 9 - 12 September 1987 .", + "entities": [] + }, + { + "id": "8684", + "type": "gene", + "text": "Risks of chronicity following acute hepatitis B virus infection : a review .", + "entities": [] + }, + { + "id": "8685", + "type": "gene", + "text": "Therefore , we have developed a system to study nuclear targeting in plants and have established that the nuclear transport machinery is similar in monocots and dicots .", + "entities": [] + }, + { + "id": "8686", + "type": "gene", + "text": "AIMS / METHODS : Reticuloendothelial system function , as assessed by clearance of radiolabelled bacteria , was evaluated in acute liver injury induced by D - galactosamine in rats , and compared with that after 70 % liver resection model .", + "entities": [] + }, + { + "id": "8687", + "type": "gene", + "text": "The corresponding differences in FVIIa and PAI - 1 were not statistically significant .", + "entities": [ + "FVIIa", + "PAI - 1" + ] + }, + { + "id": "8688", + "type": "gene", + "text": "Hybrid female mice ( C57BL x CBA ) were paired with breeder males ( CD - 1 ) and LNG pellets were implanted on day 0 , the day on which copulation plugs were found , or on day 2 or day 3 in the postcoital period .", + "entities": [] + }, + { + "id": "8689", + "type": "gene", + "text": "The sequence upstream of the rhlA promoter contains two inverted repeats which define putative binding sites for the RhlR regulator .", + "entities": [ + "rhlA promoter", + "RhlR regulator" + ] + }, + { + "id": "8690", + "type": "gene", + "text": "Indeed , ERM and c - Jun synergistically activated the EBS - CRE without making an apparent ternary complex .", + "entities": [ + "ERM", + "c - Jun" + ] + }, + { + "id": "8691", + "type": "gene", + "text": "We have examined the regulation of the FGFR - 1 gene ( cek - 1 ) in avian myogenic cultures by immunocytochemistry and Northern blot analysis .", + "entities": [ + "FGFR - 1 gene", + "cek - 1" + ] + }, + { + "id": "8692", + "type": "gene", + "text": "In the 37 patients without lung disease respiratory muscle weakness was accompanied by significant decreases in vital capacity , total lung capacity , and maximum voluntary ventilation ; by significant increases in residual volume and arterial carbon dioxide tension ( PaCO2 ) ; and greater likelihood of dependence on ventilators , atelectasis , and pneumonia .", + "entities": [] + }, + { + "id": "8693", + "type": "gene", + "text": "Clinical accuracy of updated version of the Phadebas RAST test .", + "entities": [] + }, + { + "id": "8694", + "type": "gene", + "text": "Solution structure of the IRF - 2 DNA - binding domain : a novel subgroup of the winged helix - turn - helix family .", + "entities": [ + "IRF - 2 DNA - binding domain", + "winged helix - turn - helix family" + ] + }, + { + "id": "8695", + "type": "gene", + "text": "Post - transcriptional regulation of ribosomal protein gene expression during development in Dictyostelium discoideum .", + "entities": [ + "ribosomal protein gene" + ] + }, + { + "id": "8696", + "type": "gene", + "text": "These results imply that the GCN3 product can promote either repression or activation of GCN4 expression depending on amino acid availability .", + "entities": [ + "GCN3 product", + "GCN4" + ] + }, + { + "id": "8697", + "type": "gene", + "text": "The CD4 count at which remission occurs may reflect severe immunodeficiency such that risk for AIDS - related infection is high .", + "entities": [ + "CD4" + ] + }, + { + "id": "8698", + "type": "gene", + "text": "The results point to the effectiveness of the educational intervention .", + "entities": [] + }, + { + "id": "8699", + "type": "gene", + "text": "In patients with complete or partial remission of the tumor , the neopterine excretion dropped to normal values .", + "entities": [] + }, + { + "id": "8700", + "type": "gene", + "text": "Thus , both YY1 and CDP appear to be negative regulators of the differentiation - induced HPV - 6 E1 promoter and thereby the HPV life cycle .", + "entities": [ + "YY1", + "CDP", + "HPV - 6 E1 promoter" + ] + }, + { + "id": "8701", + "type": "gene", + "text": "Cholinesterase", + "entities": [] + }, + { + "id": "8702", + "type": "gene", + "text": "In this study , we describe a mammalian cell - free transcription system reconstituted with only recombinant proteins and epitope - tagged multiprotein complexes .", + "entities": [] + }, + { + "id": "8703", + "type": "gene", + "text": "Occupational asthma and rhinoconjunctivitis from inhalation of crystalline bovine serum albumin powder .", + "entities": [ + "bovine serum albumin" + ] + }, + { + "id": "8704", + "type": "gene", + "text": "This and previous results suggest that the CRE and Sp1 site may synergistically activate TH transcription in a promoter context - dependent manner .", + "entities": [ + "Sp1 site", + "TH" + ] + }, + { + "id": "8705", + "type": "gene", + "text": "A dose of 3 and 6 micrograms / kg / day GM - CSF reduces the severity of neutropenia and thrombocytopenia after carboplatin - cyclophosphamide chemotherapy , which may lead to more effective chemotherapy for ovarian cancer in the future .", + "entities": [ + "GM - CSF" + ] + }, + { + "id": "8706", + "type": "gene", + "text": "HFA 134a had a greater tendency to take up moisture from the environment than did HFA 227 .", + "entities": [] + }, + { + "id": "8707", + "type": "gene", + "text": "Comparative analysis of various techniques of prostatic drainage in patients with chronic obstructive prostatitis ] The efficacy of prostatic drainage using transurethral vacuum aspiration ( Introl - 4 unit ) and transrectal pneumovibromassage ( PVM - R - 01 ) was compared in 1511 patients with chronic obstructive prostatitis .", + "entities": [] + }, + { + "id": "8708", + "type": "gene", + "text": "Serial US images were obtained before and 20 , 30 , 40 , 50 , 60 , 90 , 120 , 150 , 180 , 240 , and 300 s after intravenous injection of 2 g of contrast agent using conventional and harmonic PD US .", + "entities": [] + }, + { + "id": "8709", + "type": "gene", + "text": "Results showed that the mean bond strength of H . T . V . specimens ranged from 9 . 6 to 13 . 12 kg / cm2 , while the mean bond strength of R . T . V . specimens ranged from 0 . 36 to 1 . 75 kg / cm2 .", + "entities": [] + }, + { + "id": "8710", + "type": "gene", + "text": "The pulmonary effects observed , became more pronounced with increasing NO2 concentrations ( 0 , 25 , 75 , 125 , 175 or 200 ppm , 1 ppm NO2 = 1 . 88 mg m - 3 NO2 ) and exposure times ( 5 , 10 , 20 or 30 min ) .", + "entities": [] + }, + { + "id": "8711", + "type": "gene", + "text": "Transient transfections of a construct expressing the RNA transcript defined by clone B1 . 1 into D17 cells led to the expression of an Env / Mlvi - 4 fusion protein with an apparent molecular mass of 33 kDa .", + "entities": [ + "Env", + "Mlvi - 4" + ] + }, + { + "id": "8712", + "type": "gene", + "text": "The front ( F ) interaction occurs ahead of the growing end of RNA .", + "entities": [] + }, + { + "id": "8713", + "type": "gene", + "text": "Lack of cyclin D - Cdk complexes in Rb - negative cells correlates with high levels of p16INK4 / MTS1 tumour suppressor gene product .", + "entities": [ + "cyclin D", + "Cdk", + "Rb", + "p16INK4", + "MTS1" + ] + }, + { + "id": "8714", + "type": "gene", + "text": "The number of elements and their sizes relative to the configuration were varied in a series of five experiments .", + "entities": [] + }, + { + "id": "8715", + "type": "gene", + "text": "In a randomized study on 150 patients ( ASA 1 ) undergoing induction of anaesthesia , the effects of Fentanyl ( 0 . 1 mg ) , the combination of Fentanyl ( 0 . 1 mg ) and Droperidol ( 5 mg ) ( Innovar , Thalamonal ) and Atropine ( 0 . 01 mg / kg b . w . ) alone on cardiocirculatory parameters were studied .", + "entities": [] + }, + { + "id": "8716", + "type": "gene", + "text": "Vaccinia virus ( VV ) is a potent immunogen , but the nature of VV proteins involved in the activation of the immune response of the host is not yet known .", + "entities": [] + }, + { + "id": "8717", + "type": "gene", + "text": "Measurement of anti - HCV IgM antibodies with an experimental kit", + "entities": [ + "anti - HCV IgM antibodies" + ] + }, + { + "id": "8718", + "type": "gene", + "text": "EIAV LTR sequence variability is confined mostly to a small portion of the enhancer within the U3 segment of the LTR .", + "entities": [ + "EIAV LTR sequence" + ] + }, + { + "id": "8719", + "type": "gene", + "text": "In transformed E . coli , constitutive CAT expression is maintained when as little as 0 . 3 kilobase of DNA from the 3 ' end of the 1 . 6 - kilobase segment is inserted in the correct orientation in front of the CAT gene .", + "entities": [ + "constitutive CAT", + "CAT gene" + ] + }, + { + "id": "8720", + "type": "gene", + "text": "Mutational analysis of the - 84 / - 55 DNA showed that JEG - 3 nuclear proteins bound to a site containing , but not identical to , the SF - 1 sequence .", + "entities": [ + "SF - 1 sequence" + ] + }, + { + "id": "8721", + "type": "gene", + "text": "Dentalplaque was controlled by the oral higienic index of the whole dentition daily , after staining with 1 per cent alkaline fuxin .", + "entities": [] + }, + { + "id": "8722", + "type": "gene", + "text": "Reproductive period affects water intake in heat - stressed dehydrated goats .", + "entities": [] + }, + { + "id": "8723", + "type": "gene", + "text": "This protein - protein interaction does not require the simultaneous binding of Oct proteins to DNA , and high resolution footprinting of the Oct - DNA interaction reveals that binding of BOB . 1 / OBF . 1 to Oct1 or Oct2 does not alter the interaction with DNA .", + "entities": [ + "Oct proteins", + "Oct - DNA", + "BOB . 1", + "OBF . 1", + "Oct1", + "Oct2" + ] + }, + { + "id": "8724", + "type": "gene", + "text": "The observed sequence variation disrupts the first ORF in many Y ' s while most of the second ORF including the putative helicase region is unaffected .", + "entities": [ + "Y", + "helicase region" + ] + }, + { + "id": "8725", + "type": "gene", + "text": "Significant immunoglobulinuria developed prior to the development of azotemia , significantly decreased creatinine clearance , significant proteinuria ( greater than or equal to 3 + dipstick or greater than or equal to 5 gm per 24 - hour urine collection ) , or oliguria .", + "entities": [] + }, + { + "id": "8726", + "type": "gene", + "text": "Chemotherapy was administered without altering the course of the disorder .", + "entities": [] + }, + { + "id": "8727", + "type": "gene", + "text": "Quantum - statistical theory of high - field transport phenomena .", + "entities": [] + }, + { + "id": "8728", + "type": "gene", + "text": "Gestational trophoblastic diseases : recent advances in the understanding of cytogenetics , histopathology , and natural history .", + "entities": [] + }, + { + "id": "8729", + "type": "gene", + "text": "Fast continuous expansion .", + "entities": [] + }, + { + "id": "8730", + "type": "gene", + "text": "Serum concentrations of bone specific alkaline phosphatase ( BALP ) and osteocalcin ( bone Gla protein , BGP ) , urinary levels of pyridinoline ( Pyr ) and deoxypyridinoline ( Dpyr ) and computed tomography ( CT ) measurements of the cross - sectional areas of the vertebrae and the femurs , the apparent density of cancellous bone in the vertebrae , and the volume and the material density of cortical bone in the femurs were determined in 126 boys and 143 girls , ages 7 - 18 years .", + "entities": [ + "bone specific alkaline phosphatase", + "BALP", + "osteocalcin", + "bone Gla protein", + "BGP" + ] + }, + { + "id": "8731", + "type": "gene", + "text": "PPD - specific IgG subclass responses were evident to all four IgG subclasses .", + "entities": [ + "PPD", + "IgG", + "IgG" + ] + }, + { + "id": "8732", + "type": "gene", + "text": "Cyclin A expression is repressed in quiescent cells by E2F acting in conjunction with its pocket protein partners Rb , p107 , and p130 ; however , v - Jun overrides this control , causing phosphorylated Rb and proliferation - specific E2F - p107 complexes to persist after mitogen withdrawal .", + "entities": [ + "Cyclin A", + "E2F", + "Rb", + "p107", + "p130", + "v - Jun", + "Rb", + "E2F", + "p107" + ] + }, + { + "id": "8733", + "type": "gene", + "text": "The Jenkins Activity Survey and the CPI - revised : further evidence of adaptive and maladaptive type A traits .", + "entities": [] + }, + { + "id": "8734", + "type": "gene", + "text": "However , subcutaneously administered pneumococci gave a lower mortality than pneumococci given intravenously or intraperitoneally .", + "entities": [] + }, + { + "id": "8735", + "type": "gene", + "text": "Chronic nutritional diseases of infectious origin : an assessment of a nascent field .", + "entities": [] + }, + { + "id": "8736", + "type": "gene", + "text": "7 .", + "entities": [] + }, + { + "id": "8737", + "type": "gene", + "text": "This study examines the cooperative effects of a human estrogen receptor - alpha ( ERalpha ) isoform on estrogen ( E2 ) - mediated gene activation in U2 - OS osteosarcoma cells .", + "entities": [ + "estrogen receptor - alpha", + "ERalpha" + ] + }, + { + "id": "8738", + "type": "gene", + "text": "Val - - > Ala mutations selectively alter helix - helix packing in the transmembrane segment of phage M13 coat protein .", + "entities": [ + "phage M13 coat protein" + ] + }, + { + "id": "8739", + "type": "gene", + "text": "Furthermore , the insertion of the ColE1 cer site into the RK2 plasmid deleted for the par region failed to stabilize the plasmid in the MC1061K strain , indicating that the multimer resolution activity encoded by parCBA is not by itself responsible for the stabilization activity observed for this operon .", + "entities": [ + "ColE1 cer site", + "parCBA" + ] + }, + { + "id": "8740", + "type": "gene", + "text": "We show that CBF - A and CBF - C interact with each other to form a CBF - A - CBF - C complex and that CBF - B does not interact with CBF - A or CBF - C individually but that it associates with the CBF - A - CBF - C complex .", + "entities": [ + "CBF - A", + "CBF - C", + "CBF - A", + "CBF - C", + "CBF - B", + "CBF - A", + "CBF - C", + "CBF - A", + "CBF - C" + ] + }, + { + "id": "8741", + "type": "gene", + "text": "In on - going screening programmes , the Haemoccult test consists of six slides and a test is considered positive if at least one slide is coloured .", + "entities": [] + }, + { + "id": "8742", + "type": "gene", + "text": "Fission yeast mal2 + is required for chromosome segregation .", + "entities": [ + "Fission yeast mal2 +" + ] + }, + { + "id": "8743", + "type": "gene", + "text": "The eluting solvent was methanol - chloroform ( 10 + 90 ) at a flow rate of 2 . 0 ml / min .", + "entities": [] + }, + { + "id": "8744", + "type": "gene", + "text": "Viral genomic RNA for these reactions was obtained directly from fecal specimens of infected infant rats .", + "entities": [] + }, + { + "id": "8745", + "type": "gene", + "text": "In summary , at equianesthetic concentrations , desflurane and isoflurane produced similar hemodynamic effects ; however , in the absence of drugs that inhibit autonomic reflexes , desflurane had less negative inotropic activity and produced less decrease in arterial pressure .", + "entities": [] + }, + { + "id": "8746", + "type": "gene", + "text": "A stretch of 16 nucleotides just upstream of the IL - 4RE contributed to IL - 4 inducibility and formed nucleoprotein complexes with constitutive factors .", + "entities": [ + "IL - 4RE", + "IL - 4" + ] + }, + { + "id": "8747", + "type": "gene", + "text": "In two experiments , neonatal female BALB / cCrgl or BALB / cfC3HCrgl mice were given subcutaneous injections of 5 micrograms 17 beta - estradiol or sesame oil for the first 3 days of life and were ovariectomized at 60 days of age , at which time vaginal concretions ( Experiments I and II ) or silica ( Experiment II ) were implanted intravaginally .", + "entities": [] + }, + { + "id": "8748", + "type": "gene", + "text": "Post - translational modifications such as glycosylation and phosphorylation could be excluded as potential explanations for the protein heterogeneity .", + "entities": [] + }, + { + "id": "8749", + "type": "gene", + "text": "Recovery of radiolabelled BA through urine ( 28 % ) and faeces ( 22 % ) up to 96 hrs averaged 50 % , whereas residual radioactivity in liver and testis experienced a recovery of 29 % in scorbutic animals .", + "entities": [] + }, + { + "id": "8750", + "type": "gene", + "text": "During the febrile period , pleocytosis was associated with high levels of IgG , IL - 6 , TNF - alpha , and PGE2 in the cerebrospinal fluid .", + "entities": [ + "IgG", + "IL - 6", + "TNF - alpha" + ] + }, + { + "id": "8751", + "type": "gene", + "text": "Observations on the flight activities of Chrysops caecutiens L .", + "entities": [] + }, + { + "id": "8752", + "type": "gene", + "text": "A cDNA library of tumour cells was screened with an interleukin 2 gene - specific probe .", + "entities": [ + "interleukin 2" + ] + }, + { + "id": "8753", + "type": "gene", + "text": "The microcirculatory dynamics of prostaglandin E1 and / or nicardipine and their different reactions in the hyper - and hypodynamic state of septic shock in a rat model", + "entities": [] + }, + { + "id": "8754", + "type": "gene", + "text": "The effect of pure natural porcine secretin on endocrine and exocrine pancreatic secretion was studied in the totally isolated perfused porcine pancreas .", + "entities": [ + "porcine secretin" + ] + }, + { + "id": "8755", + "type": "gene", + "text": "Candidate tumor suppressor genes , Mts1 ( p16INK4a ) and Mts2 ( p15INK4b ) , have been mapped to this region , but by Southern blot analysis , no homozygous deletions were detected in either gene .", + "entities": [ + "Mts1", + "p16INK4a", + "Mts2", + "p15INK4b" + ] + }, + { + "id": "8756", + "type": "gene", + "text": "The pen can heal .", + "entities": [] + }, + { + "id": "8757", + "type": "gene", + "text": "Furthermore , analysis of deletion promoter - reporter constructs found that the basal activity of P2 resided in the proximal region of P2 .", + "entities": [] + }, + { + "id": "8758", + "type": "gene", + "text": "We used deletion analysis and transfection assays with reporter gene constructs to examine the transcription control elements in the 5 ' flanking region of the human EpoR gene .", + "entities": [ + "human EpoR gene" + ] + }, + { + "id": "8759", + "type": "gene", + "text": "The disturbance of pulmonary gas exchange , as revealed by the high value of AaDO2 , existed without left ventricular dysfunction , and AaDO2 had no significant relationship with any of the hemodynamic parameters including the difference between plasma colloid osmotic pressure and PCW .", + "entities": [] + }, + { + "id": "8760", + "type": "gene", + "text": "The addition of an equimolar complex of the fourth and seventh largest subunits , purified from pol II holoenzyme by ion - exchange chromatography in the presence of urea , restored promoter - directed initiation activity to pol II delta 4 / 7 .", + "entities": [ + "pol II holoenzyme", + "pol II delta 4 / 7" + ] + }, + { + "id": "8761", + "type": "gene", + "text": "Since the 5 ' - flanking region of this gene is likely involved in hormonal regulation of its expression , we have isolated and partially characterized an avian fatty acid synthase gene .", + "entities": [ + "fatty acid synthase" + ] + }, + { + "id": "8762", + "type": "gene", + "text": "Behind the ATPase cluster , two open reading frames were detected that are not homologous to any known chloroplast gene .", + "entities": [ + "ATPase cluster" + ] + }, + { + "id": "8763", + "type": "gene", + "text": "These data indicate that expansion of the dodecamer repeat located in the proximal promoter of CSTB severely disrupts the function of the promoter and thereby reduces transcription of CSTB .", + "entities": [ + "CSTB", + "CSTB" + ] + }, + { + "id": "8764", + "type": "gene", + "text": "We have screened the mouse cDNA library of an MIN6 cell line , derived from pancreatic beta cells , for its novel isoform and have identified a cDNA encoding a 593 - amino acid protein having 63 , 53 , and 30 % identity with munc - 18 / n - Sec1 / rbSec1 , Caenorhabditis elegans unc18 , and Saccharomyces cerevisiae Sec1p , respectively .", + "entities": [ + "munc - 18 / n - Sec1 / rbSec1", + "Caenorhabditis elegans unc18", + "Saccharomyces cerevisiae Sec1p" + ] + }, + { + "id": "8765", + "type": "gene", + "text": "The importance of this new epidemiological profile of schistosomiasis in the State of Pernambuco relies on the fact that it can be related with the drastic human interference on the environment .", + "entities": [] + }, + { + "id": "8766", + "type": "gene", + "text": "Of 208 eligible subjects , 82 received supervised IPT at a dose of 900 mg twice weekly for 6 mo ( Regimen A ) , 73 received unsupervised IPT 900 mg twice weekly for 6 mo ( Regimen B ) , and 53 received unsupervised IPT 300 mg daily for 6 mo ( Regimen C ) .", + "entities": [] + }, + { + "id": "8767", + "type": "gene", + "text": "Other therapies are also available , including hypertonic saline solution , THAM ( Tris - hydroxy - methyl - aminomethane ) buffer , and high - dose barbiturates .", + "entities": [] + }, + { + "id": "8768", + "type": "gene", + "text": "Effects of estradiol on worm burden and peripheral leukocytes in Parastrongylus malaysiensis - infected rats .", + "entities": [] + }, + { + "id": "8769", + "type": "gene", + "text": "In contrast , resensitization of a sequestration - impaired beta2AR mutant ( Y326A ) was reestablished following the overexpression of either GRK2 or beta - arrestin 1 .", + "entities": [ + "beta2AR", + "GRK2", + "beta - arrestin 1" + ] + }, + { + "id": "8770", + "type": "gene", + "text": "For sputum interleukin - 8 there was an estimated true treatment median difference of 142 pg / ml ( 95 % confidence interval ( CI ) 8 to 2866 pg / ml ) in favour of placebo ; while for maximal expiratory flow at 25 % ( MEF25 % ) remaining forced vital capacity predicted for sex and height there was a 15 percentage points ( pp ) ( 95 % CI 4 to 26 pp ) mean treatment difference in favour of placebo .", + "entities": [ + "sputum interleukin - 8" + ] + }, + { + "id": "8771", + "type": "gene", + "text": "The Psc2 cDNA contained an open reading frame homologous to CP2 family proteins .", + "entities": [ + "Psc2 cDNA", + "CP2 family proteins" + ] + }, + { + "id": "8772", + "type": "gene", + "text": "The technique of the TEE visualization of the proximal coronary arteries is described .", + "entities": [] + }, + { + "id": "8773", + "type": "gene", + "text": "The C - terminal approximately 50 amino acids of Bel - 1 are shown to be essential for Bel - 1 activity but can be effectively substituted by the C - terminal activation domain of VP16 .", + "entities": [ + "Bel - 1", + "Bel - 1", + "VP16" + ] + }, + { + "id": "8774", + "type": "gene", + "text": "The importance of posttranslational regulation of p15INK4B by TGF - beta is underlined by the observation that in TGF - beta - resistant 184A1L5R , although the p15 transcript increased , p15INK4B protein was not stabilized and did not accumulate , and cyclin D1 - cdk association and kinase activation were not inhibited .", + "entities": [ + "p15INK4B", + "TGF - beta", + "TGF - beta", + "p15 transcript", + "p15INK4B protein", + "cyclin D1", + "cdk" + ] + }, + { + "id": "8775", + "type": "gene", + "text": "The binding specificity of this protein was compared to that of human E2F using a number of mutant E2F sites as competitors .", + "entities": [ + "human E2F", + "mutant E2F sites" + ] + }, + { + "id": "8776", + "type": "gene", + "text": "Northern blot analyses demonstrate that 3 . 9 - and 5 - kilobase mRNAs corresponding to the cDNA were present in all tissues examined , suggesting that the protein it encodes performs a housekeeping function .", + "entities": [] + }, + { + "id": "8777", + "type": "gene", + "text": "The case for neutrinos from SN 1987A .", + "entities": [] + }, + { + "id": "8778", + "type": "gene", + "text": "Somatostatin gene expression in pancreatic islet cells is directed by cell - specific DNA control elements and DNA - binding proteins .", + "entities": [ + "Somatostatin gene" + ] + }, + { + "id": "8779", + "type": "gene", + "text": "( 1995 ) J .", + "entities": [] + }, + { + "id": "8780", + "type": "gene", + "text": "A bovine abomasum lambda gt11 cDNA library was screened with a monoclonal antibody raised against the rabbit H , K - ATPase beta subunit .", + "entities": [ + "rabbit H , K - ATPase beta subunit" + ] + }, + { + "id": "8781", + "type": "gene", + "text": "The data further indicate that the IL - 7R alpha chains are directly involved in the activation of JAKs and STATs and have a major role in proliferative signaling in precursor B cells .", + "entities": [ + "IL - 7R alpha chains", + "JAKs", + "STATs" + ] + }, + { + "id": "8782", + "type": "gene", + "text": "TSC1 mutations include two nonsense mutations , four insertions , and three splice mutations .", + "entities": [ + "TSC1 mutations" + ] + }, + { + "id": "8783", + "type": "gene", + "text": "PROCEDURE : Cannulas were surgically positioned in the abomasal body and pyloric antrum of each calf .", + "entities": [] + }, + { + "id": "8784", + "type": "gene", + "text": "Effect of ingestion of Norbiogest during the quiescent period of the genital organs", + "entities": [] + }, + { + "id": "8785", + "type": "gene", + "text": "Expression in established LCLs , occurring irrespective of virus producer status , was not a consequence of continued in vitro passage ; thus , appropriately spliced BamHI - A transcripts could be amplified from normal B cells within 1 day of their experimental infection in vitro , along with BamHI - C / W promoter - initiated but not BamHI - F promoter - initiated mRNAs .", + "entities": [ + "BamHI - A transcripts", + "BamHI - C / W", + "BamHI - F promoter - initiated mRNAs" + ] + }, + { + "id": "8786", + "type": "gene", + "text": "Effect of proteolytic enzymes and polypeptides on the antacid activity of almagate and other antacids .", + "entities": [] + }, + { + "id": "8787", + "type": "gene", + "text": "Characterization of fus1 of Schizosaccharomyces pombe : a developmentally controlled function needed for conjugation .", + "entities": [ + "fus1" + ] + }, + { + "id": "8788", + "type": "gene", + "text": "IgE levels showed higher values compared to normal individuals and IgE levels were higher in children groups than in adults regardless of the intensity of infection .", + "entities": [ + "IgE", + "IgE" + ] + }, + { + "id": "8789", + "type": "gene", + "text": "The nature of the process formed by the successive occurrences of this arrhythmia was studied in 8 patients with a history of symptomatic paroxysmal AF .", + "entities": [] + }, + { + "id": "8790", + "type": "gene", + "text": "This effect was not seen in conjunction with oxycodone , a morphine - like mu - receptor agonist .", + "entities": [ + "morphine - like mu - receptor" + ] + }, + { + "id": "8791", + "type": "gene", + "text": "RNAs are not only essential components of both ribosomal subunits but also transiently interacting factors during particle formation .", + "entities": [] + }, + { + "id": "8792", + "type": "gene", + "text": "We found a direct correlation between the levels of transcription of the acc genes and the rate of cellular growth .", + "entities": [ + "acc genes" + ] + }, + { + "id": "8793", + "type": "gene", + "text": "This tendency is likely due to the biased nucleotide composition of the asparagus genome , rather than to the translational selection for specific codons .", + "entities": [] + }, + { + "id": "8794", + "type": "gene", + "text": "A role for RalGDS and a novel Ras effector in the Ras - mediated inhibition of skeletal myogenesis .", + "entities": [ + "RalGDS", + "Ras", + "Ras" + ] + }, + { + "id": "8795", + "type": "gene", + "text": "Icterus and beta - thalassemia in Congolese children in Brazzaville", + "entities": [] + }, + { + "id": "8796", + "type": "gene", + "text": "In the pRb ( - ) SAOS - 2 cell line transiently transfected with a reporter plasmid containing six tal - 1 binding site , pRb enhances the transcriptional activity of tal - 1 - E12 - Lmo2 and tal - 1 - E12 - Lmo2 - Ldb1 complexes but not that of a tal - 1 - E12 heterodimer .", + "entities": [ + "pRb ( - )", + "tal - 1 binding site", + "pRb", + "tal - 1", + "E12", + "Lmo2", + "tal - 1", + "E12", + "Lmo2", + "Ldb1", + "tal - 1", + "E12" + ] + }, + { + "id": "8797", + "type": "gene", + "text": "Increasing the phosphorus content of the diet improved the reabsorption of calcium and magnesium .", + "entities": [] + }, + { + "id": "8798", + "type": "gene", + "text": "Comparison with the bovine gene showed that the 5 ' - flanking region of the hATP1 gene has an unconserved guanine - cytosine ( GC ) rich region , including several binding motifs of transcriptional factors , such as Sp1 , AP - 2 , and GCF .", + "entities": [ + "hATP1 gene", + "Sp1", + "AP - 2", + "GCF" + ] + }, + { + "id": "8799", + "type": "gene", + "text": "IGF I and insulin receptors are homologous proteins that function in distinct physiological pathways .", + "entities": [ + "IGF I", + "insulin receptors" + ] + }, + { + "id": "8800", + "type": "gene", + "text": "Drugs that are transformed via phase II reactions usually do not require dosage adjustment .", + "entities": [] + }, + { + "id": "8801", + "type": "gene", + "text": "PNRC : a proline - rich nuclear receptor coregulatory protein that modulates transcriptional activation of multiple nuclear receptors including orphan receptors SF1 ( steroidogenic factor 1 ) and ERRalpha1 ( estrogen related receptor alpha - 1 ) .", + "entities": [ + "PNRC", + "SF1", + "steroidogenic factor 1", + "ERRalpha1", + "estrogen related receptor alpha - 1" + ] + }, + { + "id": "8802", + "type": "gene", + "text": "Research on ethylene glycol and diethylene glycol for carcinogenic effects", + "entities": [] + }, + { + "id": "8803", + "type": "gene", + "text": "Carbon catabolite repression of the gnt operon of Bacillus subtilis is mediated by the catabolite control protein CcpA and by HPr , a phosphocarrier protein of the phosphotransferase system .", + "entities": [ + "gnt operon of Bacillus subtilis", + "CcpA", + "HPr" + ] + }, + { + "id": "8804", + "type": "gene", + "text": "The need for including forensic medical expertise in the list of urgent criminal investigative actions", + "entities": [] + }, + { + "id": "8805", + "type": "gene", + "text": "Patients with acute myocardial infarction had higher plasma concentrations of neutrophil elastase and the non - peroxide diene conjugated isomer of linoleic acid than normal volunteers or patients with stable ischaemic heart disease .", + "entities": [ + "neutrophil elastase" + ] + }, + { + "id": "8806", + "type": "gene", + "text": "Each binding site , however , was different in its preference for binding partners .", + "entities": [] + }, + { + "id": "8807", + "type": "gene", + "text": "The TEA1 ( Ty enhancer activator ) gene sequence predicts a protein of 86 . 9 kDa whose N terminus contains a zinc cluster and dimerization motif typical of the Gal4 - type family of DNA - binding proteins .", + "entities": [ + "TEA1", + "Ty enhancer activator", + "Gal4 - type family" + ] + }, + { + "id": "8808", + "type": "gene", + "text": "Chemical uptake into human stratum corneum in vivo from volatile and non - volatile solvents .", + "entities": [] + }, + { + "id": "8809", + "type": "gene", + "text": "On the trail of Dr .", + "entities": [] + }, + { + "id": "8810", + "type": "gene", + "text": "We have cloned a novel protein kinase , termed hematopoietic progenitor kinase 1 ( HPK1 ) , that is expressed predominantly in hematopoietic cells , including early progenitor cells .", + "entities": [ + "hematopoietic progenitor kinase 1", + "HPK1" + ] + }, + { + "id": "8811", + "type": "gene", + "text": "Histological analysis showed that the neuronal loss in the DHED - treated group was notably reduced in the hippocampal area ( CA1 ) of ischemic rats and in the dentate gyrus and hippocampal area ( CA1 and CA3 ) of EC - lesioned rats compared with the nontreated group .", + "entities": [] + }, + { + "id": "8812", + "type": "gene", + "text": "These well - characterized brain regions may provide a basis for future studies of RPTP - kappa function .", + "entities": [ + "RPTP - kappa" + ] + }, + { + "id": "8813", + "type": "gene", + "text": "From May 1985 to May 1989 , 126 necropsies were performed at the Sao Paulo City Morgue on cadavers of individuals AIDS victims whose unnatural deaths had prompted police investigations .", + "entities": [] + }, + { + "id": "8814", + "type": "gene", + "text": "In a longitudinal study , 14 low - risk fetuses were studied at 2 - week intervals from 32 weeks of gestation onward .", + "entities": [] + }, + { + "id": "8815", + "type": "gene", + "text": "Our results also indicate the existence of sequences downstream of - 0 . 11 kb which can influence the pattern of tissue - specific expression of the HLA - B7 gene and the ability of this gene to respond to gamma interferon .", + "entities": [ + "HLA - B7 gene", + "gamma interferon" + ] + }, + { + "id": "8816", + "type": "gene", + "text": "The astronaut crew operates the payload and documents its operation .", + "entities": [] + }, + { + "id": "8817", + "type": "gene", + "text": "The human T cell leukemia / lymphotropic virus type 1 Tax protein represses MyoD - dependent transcription by inhibiting MyoD - binding to the KIX domain of p300 .", + "entities": [ + "human T cell leukemia / lymphotropic virus type 1 Tax protein", + "MyoD", + "MyoD", + "KIX domain", + "p300" + ] + }, + { + "id": "8818", + "type": "gene", + "text": "Our results demonstrate that the promoter and enhancer regions identified here are essential for maintaining the efficient promoter activity of the human activin betaA subunit gene .", + "entities": [ + "human activin betaA subunit gene" + ] + }, + { + "id": "8819", + "type": "gene", + "text": "None of the patients was obese .", + "entities": [] + }, + { + "id": "8820", + "type": "gene", + "text": "The bases of this comparison are reviewed and discussed .", + "entities": [] + }, + { + "id": "8821", + "type": "gene", + "text": "Point mutations of the five tyrosine residues in the cytoplasmic domain of the receptor were subsequently used to confirm our conclusions .", + "entities": [] + }, + { + "id": "8822", + "type": "gene", + "text": "A range of normal ventricular measurements for the EMI scan is suggested .", + "entities": [] + }, + { + "id": "8823", + "type": "gene", + "text": "Sequence analysis identified some of these cDNA clones as Dlc - 1 , a sequence encoding a small , 9 - kDa human homolog of the outer - arm dynein light - chain protein .", + "entities": [ + "Dlc - 1", + "9 - kDa human homolog of the outer - arm dynein light - chain" + ] + }, + { + "id": "8824", + "type": "gene", + "text": "Increasing the extracellular calcium concentration enhanced detrusor contractility in a dose - dependent manner in both control and obstructed bladders .", + "entities": [] + }, + { + "id": "8825", + "type": "gene", + "text": "With this bisected diastolic driving , the abnormal echo disappeared completely .", + "entities": [] + }, + { + "id": "8826", + "type": "gene", + "text": "Effect of nitrous oxide ( N2O ) on the somatosympathetic A - and C - reflexes was investigated using artificially ventilated rats anesthetized with alpha - chloralose and urethane .", + "entities": [] + }, + { + "id": "8827", + "type": "gene", + "text": "Mean longitudinal extension of the epidural lesion was 2 . 6 vertebral segments .", + "entities": [] + }, + { + "id": "8828", + "type": "gene", + "text": "Sensitivities of thromboplastins to factor VII deficiency .", + "entities": [ + "thromboplastins", + "factor VII" + ] + }, + { + "id": "8829", + "type": "gene", + "text": "Since the RINX gene is likely an ortholog of the goldfish Vsx1 gene , it has been named VSX1 by the Human Gene Nomenclature Committee .", + "entities": [ + "RINX gene", + "goldfish Vsx1 gene", + "VSX1" + ] + }, + { + "id": "8830", + "type": "gene", + "text": "These changes weren ' t so significant in the group of obese children who didn ' t lose weight .", + "entities": [] + }, + { + "id": "8831", + "type": "gene", + "text": "Thus , VF resistant to defibrillation is not necessarily associated with both toxic plasma drug level and remarkably decreased conduction .", + "entities": [] + }, + { + "id": "8832", + "type": "gene", + "text": "Antibiotic effect of the mud from heviz", + "entities": [] + }, + { + "id": "8833", + "type": "gene", + "text": "Promoter recognition algorithms identified divergent promoter elements within the CpG island , which lies between the ATM and E14 / NPAT genes , and provide evidence for a putative second ATM promoter located within intron 3 , immediately upstream of the first coding exon .", + "entities": [ + "ATM", + "E14", + "NPAT", + "ATM promoter" + ] + }, + { + "id": "8834", + "type": "gene", + "text": "The amount of these factors was reduced in GEO cells in which the u - PAR gene is only weakly transcriptionally activated .", + "entities": [ + "u - PAR gene" + ] + }, + { + "id": "8835", + "type": "gene", + "text": "It contains three putative TATA boxes far upstream of the main start sites region , one AP - 1 box , one AP - 2 box , one Malt box , one GAGA box , one half serum - responsive element , and putative binding sites for Sp1 ( five ) , GC - rich binding factor ( five ) , CTF - NF1 ( one ) , Myb ( one ) , p53 ( two ) , Ets - 1 ( one ) , NF - IL6 ( two ) , MyoD ( two ) , Zeste ( one ) , and hepatocyte nuclear factor - 5 ( one ) .", + "entities": [ + "AP - 1 box", + "AP - 2 box", + "Malt box", + "Sp1", + "GC - rich binding factor", + "CTF - NF1", + "Myb", + "p53", + "Ets - 1", + "NF - IL6", + "MyoD", + "Zeste", + "hepatocyte nuclear factor - 5" + ] + }, + { + "id": "8836", + "type": "gene", + "text": "Cross - linking the B cell Ag receptor ( BCR ) to surface Fc receptors for IgG ( Fc gamma R ) inhibits G1 - to - S progression ; the mechanism by which this occurs is not completely known .", + "entities": [ + "B cell Ag receptor", + "BCR", + "surface Fc receptors", + "IgG", + "Fc gamma R" + ] + }, + { + "id": "8837", + "type": "gene", + "text": "Terazosin , a structural analog of prazosin , also inhibits alpha 1 adrenoceptors and is recommended as once or twice - daily therapy .", + "entities": [ + "alpha 1 adrenoceptors" + ] + }, + { + "id": "8838", + "type": "gene", + "text": "Rip1p is inessential , associated with nuclear pore complexes , and structurally related to the FG - nucleoporin family of pore proteins .", + "entities": [ + "Rip1p", + "FG - nucleoporin family" + ] + }, + { + "id": "8839", + "type": "gene", + "text": "BCR - ABL and v - abl oncogenes induce distinct patterns of thymic lymphoma involving different lymphocyte subsets .", + "entities": [ + "BCR", + "ABL", + "v - abl oncogenes" + ] + }, + { + "id": "8840", + "type": "gene", + "text": "Chenodeoxycholic acid ( cheno ) and ursodeoxycholic acid ( urso ) dissolve cholesterol gallstones in man .", + "entities": [] + }, + { + "id": "8841", + "type": "gene", + "text": "TIEG expression in hFOB cells was highly induced by TGF - beta and bone morphogenetic protein - 2 ( BMP - 2 ) , with a moderate induction by epidermal growth factor ( EGF ) , but no induction by other growth factors / cytokines was observed .", + "entities": [ + "TIEG", + "TGF - beta", + "bone morphogenetic protein - 2", + "BMP - 2", + "epidermal growth factor", + "EGF" + ] + }, + { + "id": "8842", + "type": "gene", + "text": "Concussion of the spinal cord", + "entities": [] + }, + { + "id": "8843", + "type": "gene", + "text": "T2 cancers should not be excluded from the benefit of preoperative irradiation .", + "entities": [] + }, + { + "id": "8844", + "type": "gene", + "text": "Lethal Tachmalcor ( 4 - ( 3 ' - diethylamino - 2 ' - hydroxypropyl ) - ajmaline ) poisoning in childhood", + "entities": [] + }, + { + "id": "8845", + "type": "gene", + "text": "Unusual two - domain arginine kinases ( AKs ) arose independently at least two times during molecular evolution of phosphagen kinases : AKs from the primitive sea anemone Anthopleurura japonicus and from the clam Pseudocardium sachalinensis .", + "entities": [ + "two - domain arginine kinases", + "AKs", + "phosphagen kinases", + "AKs" + ] + }, + { + "id": "8846", + "type": "gene", + "text": "In broken L - cell membranes expressing wild type or mutant M6P / IGF II receptors , 30 nM IGF II also failed to affect the pertussis toxin substrate activity .", + "entities": [ + "mutant M6P / IGF II receptors", + "IGF II", + "pertussis toxin" + ] + }, + { + "id": "8847", + "type": "gene", + "text": "The mRNA from this gene , termed HES1 , is ubiquitously expressed , but strongly so in heart and skeletal muscle .", + "entities": [ + "HES1" + ] + }, + { + "id": "8848", + "type": "gene", + "text": "Molecular characterization and expression of the Erwinia carotovora hrpNEcc gene , which encodes an elicitor of the hypersensitive reaction .", + "entities": [ + "Erwinia carotovora hrpNEcc gene" + ] + }, + { + "id": "8849", + "type": "gene", + "text": "Static and dynamic compliance was measured after induction of anesthesia , before and immediately after filtration in the operating theater , 1 hour after return to the pediatric intensive care unit , and 24 hours after the operation .", + "entities": [] + }, + { + "id": "8850", + "type": "gene", + "text": "When used subcutaneously or intravenously in maximum tolerated doses the antibiotic inhibited the development of lymphadenosis NK / Li by 90 and 70 per cent respectively .", + "entities": [] + }, + { + "id": "8851", + "type": "gene", + "text": "HYPOTHESIS : The aim of this study was to investigate the oxidative susceptibility of apolipoprotein B - containing lipoproteins and antioxidant status in patients with acute coronary syndromes and chronic stable angina pectoris .", + "entities": [ + "apolipoprotein B - containing lipoproteins" + ] + }, + { + "id": "8852", + "type": "gene", + "text": "The clinical stage was I ( T1N0M0 ) , and S2 sleeve segmentectomy with lymph node dissection ( R 2 b ) was performed .", + "entities": [] + }, + { + "id": "8853", + "type": "gene", + "text": "As expected , glycosylation of Env produced from mutants was affected but , irrespective of the glycosylation phenotype , ( i ) similar quantities of Env were synthesized , ( ii ) the immunoreactivity of V3 was similar , ( iii ) gp160 was efficiently cleaved into gp120 and gp41 , ( vi ) Env was exposed at the cell membrane , ( v ) secreted gp120 bound CD4 , and ( vi ) membrane gp41 was able to induce membrane fusion with CD4 + cells .", + "entities": [ + "Env", + "Env", + "V3", + "gp160", + "gp120", + "gp41", + "Env", + "gp120", + "CD4", + "gp41", + "CD4 +" + ] + }, + { + "id": "8854", + "type": "gene", + "text": "By screening a cDNA library with a probe derived from sequences downstream of the p53p2 start site , we have cloned and characterized a cDNA that represents a mRNA that appears to have been initiated from the p53p2 promoter .", + "entities": [ + "p53p2", + "p53p2 promoter" + ] + }, + { + "id": "8855", + "type": "gene", + "text": "GLRaV - 2 is the only closterovirus , so far , that matches the genome organization of the type member of the group , BYV , and thus can be unambiguously classified as a definitive member of the genus Closterovirus .", + "entities": [] + }, + { + "id": "8856", + "type": "gene", + "text": "The requirement of different essential fatty acids in patients with total parenteral nutrition after heavy injury is of special interest with respect to the development and prognosis of shock , sepsis or adult respiratory distress syndrome .", + "entities": [] + }, + { + "id": "8857", + "type": "gene", + "text": "A comparative study of the effects of carbamazepine and the NMDA receptor antagonist remacemide on road tracking and car - following performance in actual traffic .", + "entities": [ + "NMDA receptor" + ] + }, + { + "id": "8858", + "type": "gene", + "text": "Both inhaled and superfused isoflurane dilated the baseline vein diameter before stimulation .", + "entities": [] + }, + { + "id": "8859", + "type": "gene", + "text": "The Gap69C is a single - copy gene producing a major 2 . 1 - kb mRNA throughout development , but its amount is decreased in larvae .", + "entities": [ + "Gap69C" + ] + }, + { + "id": "8860", + "type": "gene", + "text": "Mutants lacking any tyrosine residues in the cytoplasmic domain maintain their ability to activate STAT5 and STAT1 but cannot activate STAT3 , implying that STAT5 and STAT1 activation does not require receptor tyrosine phosphorylation .", + "entities": [ + "STAT5", + "STAT1", + "STAT3", + "STAT5", + "STAT1" + ] + }, + { + "id": "8861", + "type": "gene", + "text": "Because RNase III host mutants are defective in sib regulation , processing of the PL mRNA at sib by this endoribonuclease may cause int mRNA decay and decrease int synthesis .", + "entities": [ + "RNase III host mutants", + "sib", + "PL mRNA", + "sib", + "int mRNA", + "int" + ] + }, + { + "id": "8862", + "type": "gene", + "text": "The tumorigenic E1A + cHa - ras cells are characterized by high and constitutive DNA binding activities of AP - 1 , in contrast to nontransformed cells and the E1A cells .", + "entities": [ + "E1A", + "cHa - ras", + "AP - 1", + "E1A" + ] + }, + { + "id": "8863", + "type": "gene", + "text": "RESULTS : For E1 , itraconazole plasma drug concentration extrapolated to time zero ( IV dose ) was 5 . 2 + / - 1 . 4 micrograms / ml , and mean residence time ( MRT ) was 37 + / - 16 hours .", + "entities": [] + }, + { + "id": "8864", + "type": "gene", + "text": "HLA - A and B phenotypes of 105 patients suffering from malignant melanomas were determined , with special regard for metastatic form or relapse .", + "entities": [ + "HLA - A and B" + ] + }, + { + "id": "8865", + "type": "gene", + "text": "Although there was a high correlation between sap flux densities registered by the old and new sensors , significant differences in sap flux densities between the duplicated sensors were detected .", + "entities": [] + }, + { + "id": "8866", + "type": "gene", + "text": "CONCLUSIONS : Although the levels of oxLDL antibodies might be modified in early hypertension , once advanced coronary artery disease has developed the presence of hypertension does not affect anti - oxLDL levels .", + "entities": [ + "oxLDL antibodies", + "anti - oxLDL" + ] + }, + { + "id": "8867", + "type": "gene", + "text": "Comparison of the sequences of the xFxFG repeat regions of p62 and Nsplp indicated that NTF2 was probably interacting with the phenylalanine - containing core of these repeats and not the intervening hydrophilic linkers .", + "entities": [ + "p62", + "Nsplp", + "NTF2" + ] + }, + { + "id": "8868", + "type": "gene", + "text": "In addition , SLK displays high homology to microtubule and nuclear associated protein ( M - NAP ) and AT1 - 46 , both of unknown function .", + "entities": [ + "SLK", + "microtubule and nuclear associated protein", + "M - NAP", + "AT1 - 46" + ] + }, + { + "id": "8869", + "type": "gene", + "text": "Synergistic transactivation of the BMRF1 promoter by the Z / c - myb combination appears to involve direct binding by the Z protein but not the c - myb protein .", + "entities": [ + "BMRF1 promoter", + "Z", + "c - myb", + "Z protein", + "c - myb protein" + ] + }, + { + "id": "8870", + "type": "gene", + "text": "Wild type and mutant Epo cDNAs were transiently expressed at high levels in COS1 and COS7 cells .", + "entities": [ + "Wild type and mutant Epo cDNAs" + ] + }, + { + "id": "8871", + "type": "gene", + "text": "Evaluation of human and bovine modified - hemoglobin solution as oxygen - carrying fluid for blood volume replacement .", + "entities": [ + "hemoglobin" + ] + }, + { + "id": "8872", + "type": "gene", + "text": "Rather , usp is required in late third instar larvae for appropriate developmental and transcriptional responses to the ecdysone pulse that triggers puparium formation .", + "entities": [ + "usp" + ] + }, + { + "id": "8873", + "type": "gene", + "text": "The influenza virus NS1 protein is a unique posttranscriptional regulator that has two activities : inhibition of the nuclear export of poly A - containing mRNAs and inhibition of pre - mRNA splicing .", + "entities": [ + "NS1" + ] + }, + { + "id": "8874", + "type": "gene", + "text": "This last region contains two sites that bind Ets - related proteins present in liver nuclear extracts as well as recombinant purified Ets - 1 protein .", + "entities": [ + "Ets - related proteins", + "recombinant purified Ets - 1 protein" + ] + }, + { + "id": "8875", + "type": "gene", + "text": "These results indicate that cynomolgus monkeys are either less sensitive or respond differently than rhesus monkeys to some of the pharmacological effects of norcocaine .", + "entities": [] + }, + { + "id": "8876", + "type": "gene", + "text": "Thus , in stress - induced arrhythmic disease as well as in ischemic heart disease , the main pathogenetic links are outside the heart , but they differ from those observed in ischemia .", + "entities": [] + }, + { + "id": "8877", + "type": "gene", + "text": "Thus , a negative test is compatible with low disease activity and / or efficacy of calcium antagonist treatment .", + "entities": [] + }, + { + "id": "8878", + "type": "gene", + "text": "Thus , a negative test is compatible with low disease activity and / or efficacy of calcium antagonist treatment .", + "entities": [] + }, + { + "id": "8879", + "type": "gene", + "text": "Right LHR ( R - LHR ) provided the best interobserver and intraobserver reproducibility .", + "entities": [] + }, + { + "id": "8880", + "type": "gene", + "text": "One member of this multigene family , GATA - 3 , is most abundantly expressed in T lymphocytes , a cellular target for human immunodeficiency virus type 1 ( HIV - 1 ) infection and replication .", + "entities": [ + "GATA - 3" + ] + }, + { + "id": "8881", + "type": "gene", + "text": "We also discovered a V lambda pseudogene , called psi V lambda 1 , 3 kb upstream of the U266 lambda gene .", + "entities": [ + "V lambda pseudogene", + "psi V lambda 1", + "U266 lambda gene" + ] + }, + { + "id": "8882", + "type": "gene", + "text": "The influence of p53 on cytokine - triggered Janus kinase - STAT signaling was investigated in human hepatoma Hep3B cell lines engineered to constitutively express the temperature - sensitive Val135 mutant of p53 .", + "entities": [ + "p53", + "Janus kinase", + "STAT", + "Val135 mutant of p53" + ] + }, + { + "id": "8883", + "type": "gene", + "text": "We have visualized DNA - protein complexes by electron microscopy and a high - affinity binding site of WDV Rep protein within the core element has been mapped to approximately 144 + / - 18 bp upstream from the initiation site , between the start site for complementary - sense transcription and the TATA box .", + "entities": [ + "WDV Rep protein" + ] + }, + { + "id": "8884", + "type": "gene", + "text": "Additional studies revealed that bovine brain Galpha ( q / 11 ) could also bind to an N - terminal construct of GRK2 , while no binding of Galpha ( q / 11 ) , Galpha ( s ) , Galpha ( i ) , or Galpha ( 12 / 13 ) to comparable constructs of GRK5 or GRK6 was observed .", + "entities": [ + "bovine brain Galpha ( q / 11 )", + "GRK2", + "Galpha ( q / 11 )", + "Galpha ( s )", + "Galpha ( i )", + "Galpha ( 12 / 13 )", + "GRK5", + "GRK6" + ] + }, + { + "id": "8885", + "type": "gene", + "text": "RESULTS : The standardised mortality ratio ( SMR ) for all malignant neoplasms was 94 ( 95 % CI 74 to 118 ) .", + "entities": [] + }, + { + "id": "8886", + "type": "gene", + "text": "We find that our response function is well approximated by the GSER only within a particular frequency range determined by the material parameters of both the bead and the network .", + "entities": [] + }, + { + "id": "8887", + "type": "gene", + "text": "Multiple copies of rsmB + DNA , on the other hand , stimulate exoenzyme production by relieving the negative effects of a chromosomal copy of hexA + .", + "entities": [ + "rsmB + DNA", + "hexA +" + ] + }, + { + "id": "8888", + "type": "gene", + "text": "Reverse transcription ( RT ) - PCR products were synthesized with two degenerate primers derived from the conserved motifs of various tyrosine kinases .", + "entities": [ + "tyrosine kinases" + ] + }, + { + "id": "8889", + "type": "gene", + "text": "A catalytic domain of eukaryotic DNA topoisomerase I .", + "entities": [ + "eukaryotic DNA topoisomerase I" + ] + }, + { + "id": "8890", + "type": "gene", + "text": "Thus , VDR acts selectively on the two components required for activation of this promoter / enhancer : it competes with NFAT1 for binding to the composite site , positioning itself adjacent to Jun - Fos on the DNA .", + "entities": [ + "VDR", + "NFAT1", + "Jun", + "Fos" + ] + }, + { + "id": "8891", + "type": "gene", + "text": "Our studies extend these findings and show that the E2 transactivation gene is expressed from multiple promoters .", + "entities": [ + "E2 transactivation gene" + ] + }, + { + "id": "8892", + "type": "gene", + "text": "Mobility and supershift assays demonstrated that upstream stimulatory factor ( USF ) and Sp1 bind to the former elements and competition experiments confirmed that CREB / ATF and AP - 1 bind to the CRE / TRE element .", + "entities": [ + "upstream stimulatory factor", + "USF", + "Sp1", + "CREB", + "ATF", + "AP - 1" + ] + }, + { + "id": "8893", + "type": "gene", + "text": "Using a novel method combining chromatin immunoprecipitation and genomic array hybridization , we have identified a 460 - kb CENP - A - binding DNA domain of a neocentromere derived from the 20p12 region of an invdup ( 20p ) human marker chromosome .", + "entities": [ + "460 - kb CENP - A - binding DNA domain" + ] + }, + { + "id": "8894", + "type": "gene", + "text": "It contains binding sites for several transcription factors , for example : ( i ) a well - characterized binding site for rel / NF - kappaB transcription factors in its 3 ' - end ( the H2TF1 or kappaB1 element ) , ( ii ) a second kappaB site ( the kappaB2 element ) , which is located immediately adjacent 5 ' to the H2TF1 element and which is recognized by p65 / relA in the human HLA system , and ( iii ) an AP - 1 / ATF recognition sequence in the 5 ' end ( EnA - TRE ) .", + "entities": [ + "rel", + "NF - kappaB", + "H2TF1", + "kappaB1 element", + "kappaB site", + "kappaB2 element", + "H2TF1 element", + "p65", + "relA", + "human HLA", + "AP - 1", + "ATF", + "EnA - TRE" + ] + }, + { + "id": "8895", + "type": "gene", + "text": "A rare case of primary group A streptococcal peritonitis .", + "entities": [] + }, + { + "id": "8896", + "type": "gene", + "text": "Reagent strips are frequently used in the practice of laboratory medicine as well as outside the professional laboratories .", + "entities": [] + }, + { + "id": "8897", + "type": "gene", + "text": "A complete drug history was compiled , specifying the amount and duration of VGB medication .", + "entities": [] + }, + { + "id": "8898", + "type": "gene", + "text": "Protein S levels were virtually undetectable at the time of admission and failed to respond to infusions of fresh frozen plasma , despite correction of other procoagulant and anticoagulant factors .", + "entities": [ + "Protein S" + ] + }, + { + "id": "8899", + "type": "gene", + "text": "The newly defined region contains an intron that may be alternatively spliced and seven polyadenylation signal sequences .", + "entities": [] + }, + { + "id": "8900", + "type": "gene", + "text": "These combined observations define a promoter and an enhancer for the chicken L - CAM gene .", + "entities": [ + "chicken L - CAM gene" + ] + }, + { + "id": "8901", + "type": "gene", + "text": "We have also isolated and analyzed the 5 ' flanking region of the pea 33RNP gene .", + "entities": [ + "33RNP gene" + ] + }, + { + "id": "8902", + "type": "gene", + "text": "GLUT5 mRNA is expressed at highest levels in small intestine and at much lower levels in kidney , skeletal muscle , and adipose tissue .", + "entities": [ + "GLUT5 mRNA" + ] + }, + { + "id": "8903", + "type": "gene", + "text": "A novel potential effector of M - Ras and p21 Ras negatively regulates p21 Ras - mediated gene induction and cell growth .", + "entities": [ + "M - Ras", + "p21 Ras", + "p21 Ras" + ] + }, + { + "id": "8904", + "type": "gene", + "text": "NH2 - and COOH - terminal deletion analysis revealed that both the PH and putative guanine nucleotide exchange factor domains are required , but the zinc butterfly is dispensable , for transformation .", + "entities": [ + "PH", + "guanine nucleotide exchange factor domains" + ] + }, + { + "id": "8905", + "type": "gene", + "text": "The FMN moiety but not the [ 3Fe - 4S ] cluster of the subunit appears to participate in this reaction .", + "entities": [] + }, + { + "id": "8906", + "type": "gene", + "text": "We propose that the ambiguous discrimination required a greater time for simulus evaluation and that this was reflected in the delayed P3 latencies .", + "entities": [] + }, + { + "id": "8907", + "type": "gene", + "text": "We have isolated a novel human cyclin , cyclin E2 , that contains significant homology to cyclin E .", + "entities": [ + "human cyclin", + "cyclin E2", + "cyclin E" + ] + }, + { + "id": "8908", + "type": "gene", + "text": "Identification of a novel E2F3 product suggests a mechanism for determining specificity of repression by Rb proteins .", + "entities": [ + "E2F3 product", + "Rb proteins" + ] + }, + { + "id": "8909", + "type": "gene", + "text": "The alpha 4 gene 5 ' flanking region acted as a promoter in transfection assays .", + "entities": [ + "alpha 4 gene" + ] + }, + { + "id": "8910", + "type": "gene", + "text": "Mae West and the doctor shortage .", + "entities": [] + }, + { + "id": "8911", + "type": "gene", + "text": "Ion injection .", + "entities": [] + }, + { + "id": "8912", + "type": "gene", + "text": "195mPt - labeled cisplatin was administered iv and ip to control mice and to mice bearing Sarcoma 180 .", + "entities": [] + }, + { + "id": "8913", + "type": "gene", + "text": "Gamma glutamyl transpeptidase ( GGTP ) activity in the seminal fluid", + "entities": [ + "Gamma glutamyl transpeptidase", + "GGTP" + ] + }, + { + "id": "8914", + "type": "gene", + "text": "A cDNA encoding the NF - 4FB enhancer binding protein has been cloned by screening a lambda gt11 cDNA library with a rabiolabelled oligonucleotide corresponding to the NF - 4FB recognition sequence .", + "entities": [ + "NF - 4FB enhancer binding protein", + "NF - 4FB recognition sequence" + ] + }, + { + "id": "8915", + "type": "gene", + "text": "Over - expression of the cofactor p300 , which functions as a coactivator of myoD - mediated transcription , alleviated repression by COUP - TF II .", + "entities": [ + "p300", + "myoD", + "COUP - TF II" + ] + }, + { + "id": "8916", + "type": "gene", + "text": "II .", + "entities": [] + }, + { + "id": "8917", + "type": "gene", + "text": "The prevalence of CPAF was similar in type 1 and type 2 diabetes , was greater in women than in men , and was significantly greater after repeated administrations than after one single administration of chlorpropamide .", + "entities": [] + }, + { + "id": "8918", + "type": "gene", + "text": "Nuclear factor III ( NFIII ) is a protein from HeLa cells that stimulates the initiation of adenovirus type 2 ( Ad2 ) DNA replication by binding to a specific nucleotide sequence in the origin , adjacent to the nuclear factor I recognition site .", + "entities": [ + "Nuclear factor III", + "NFIII", + "nuclear factor I recognition site" + ] + }, + { + "id": "8919", + "type": "gene", + "text": "The RMR was measured twice in each phase and found to be similar ( F ( 1 , 18 ) = 0 . 863 ) across the follicular ( 5018 kJ / 24 h ) and the luteal ( 5098 kJ / 24 h ) phases .", + "entities": [] + }, + { + "id": "8920", + "type": "gene", + "text": "Through a stretch of 56 amino acids , constituting the MADS domain , the two proteins are identical except for two conservative amino acid substitutions .", + "entities": [ + "MADS domain" + ] + }, + { + "id": "8921", + "type": "gene", + "text": "Using the sequence data obtained from the human TCRAC / TCRDC region , we have extended a polymerase chain reaction - based assay to test for the expression of the individual TCRAJ gene segments .", + "entities": [ + "TCRAC", + "TCRDC", + "TCRAJ gene segments" + ] + }, + { + "id": "8922", + "type": "gene", + "text": "We have previously reported that high level human desmin expression depends on a 280 - base pair muscle - specific enhancer which can function not only in myotubes , but can also activate gene expression in myoblasts .", + "entities": [ + "human desmin" + ] + }, + { + "id": "8923", + "type": "gene", + "text": "Exchange of the LPL and HL lids resulted in a reversal of the phospholipase / neutral lipase ratio , establishing the important role of this region in mediating substrate specificity .", + "entities": [ + "LPL", + "HL", + "phospholipase", + "lipase" + ] + }, + { + "id": "8924", + "type": "gene", + "text": "Far Western blot analysis suggested that the tandem SH2 domains of SHP2 bind to Gab1 in a specific orientation , in which the N - SH2 domain binds to phosphotyrosine ( Tyr ( P ) ) - 627 and the C - SH2 domain binds to Tyr ( P ) - 659 .", + "entities": [ + "SH2 domains", + "SHP2", + "Gab1", + "N - SH2 domain", + "C - SH2 domain" + ] + }, + { + "id": "8925", + "type": "gene", + "text": "Lastly , there are multiple instances in which short oligonucleotide direct repeats flank a region absent from either variola or vaccinia virus .", + "entities": [] + }, + { + "id": "8926", + "type": "gene", + "text": "However , during our work with a replication - deficient virus expressing the ASF / SF2 splicing factor from a progesterone antagonist - inducible gene cassette , we discovered that ASF / SF2 was expressed at a significant level in the 293 producer cell line , even in the absence of inducer .", + "entities": [ + "ASF", + "SF2", + "ASF", + "SF2" + ] + }, + { + "id": "8927", + "type": "gene", + "text": "Five patients with type III musculoskeletal infection from nongonococcal Neisseria species were examined during a 13 - month period .", + "entities": [] + }, + { + "id": "8928", + "type": "gene", + "text": "On transition from high to low voltage there was a significant fall in arterial pressure ( 7 % ) and an increase in flow ( 19 - 38 % ) to areas of the brain corresponding to the arborization of the reticular formation , i . e . excluding the cerebrum and cerebellum .", + "entities": [] + }, + { + "id": "8929", + "type": "gene", + "text": "We also report here the complete structural organization of the goat alpha s1 - casein transcription unit , deduced from polymerase chain reaction experiments .", + "entities": [ + "goat alpha s1 - casein transcription unit" + ] + }, + { + "id": "8930", + "type": "gene", + "text": "Gonadotropin levels in mothers who have had two sets of DZ twins .", + "entities": [ + "Gonadotropin" + ] + }, + { + "id": "8931", + "type": "gene", + "text": "No TATA box was found in the putative promoter region , but multiple GC boxes were found around the cap sites , supporting the previously inferred housekeeping nature of CYP51 gene and the existence of the multiple transcription initiation sites .", + "entities": [ + "CYP51 gene" + ] + }, + { + "id": "8932", + "type": "gene", + "text": "It is concluded that stereotypy can be evoked also in the case when the striatal dopaminergic tone is normal or even below normal : it is the equilibrium of the striatal cholinergic - dopaminergic systems which must be shifted towards dopamine , which is necessary for the development of this behavioral manifestation .", + "entities": [] + }, + { + "id": "8933", + "type": "gene", + "text": "The relationship of the factor V Leiden mutation or the deletion - deletion polymorphism of the angiotensin converting enzyme to postoperative thromboembolic events following total joint arthroplasty .", + "entities": [ + "factor V Leiden mutation", + "angiotensin converting enzyme" + ] + }, + { + "id": "8934", + "type": "gene", + "text": "Spontaneous burst firing in cat primary auditory cortex : age and depth dependence and its effect on neural interaction measures .", + "entities": [] + }, + { + "id": "8935", + "type": "gene", + "text": "Studies on the hereditary nature of sole prints - - with special reference to interdigital and triradii", + "entities": [] + }, + { + "id": "8936", + "type": "gene", + "text": "Thyroid function tests were performed on 300 admissions , leaving 707 untested .", + "entities": [] + }, + { + "id": "8937", + "type": "gene", + "text": "Maize rbcS promoter activity depends on sequence elements not found in dicot rbcS promoters .", + "entities": [ + "Maize rbcS promoter", + "dicot rbcS promoters" + ] + }, + { + "id": "8938", + "type": "gene", + "text": "Cyclin D1 - associated kinase activity and protein levels were increased in mammary tumors from murine mammary tumor virus - pp60 ( c - src527F ) transgenic mice .", + "entities": [ + "Cyclin D1 - associated kinase", + "pp60", + "c - src527F" + ] + }, + { + "id": "8939", + "type": "gene", + "text": "CONCLUSIONS : The myocardial uptake of 99mTc sestamibi in normal subjects and patients with coronary artery disease is comparable after exercise , dipyridamole , and adenosine stress .", + "entities": [] + }, + { + "id": "8940", + "type": "gene", + "text": "Our mapping results did not suggest involvement of this gene in previously mapped genetic disorders or in known neoplasia - associated translocation breakpoints .", + "entities": [] + }, + { + "id": "8941", + "type": "gene", + "text": "We examined the hypothesis that the coronary vasomotor responses to etomidate ( ETO ) , propofol ( PRO ) , and sodium thiopental ( STP ) are mediated through contrasting effects on the resting nitric oxide ( NO ) - dependent vasodilator tone that opposes adrenergic vasoconstrictor activity in the intact dog .", + "entities": [] + }, + { + "id": "8942", + "type": "gene", + "text": "In gel mobility shift assays , low binding activity of CBF to the wild - type AtpC promoter sequence was observed with nuclear extracts from tissue with low AtpC expression levels , i . e . extracts from etiolated and photobleached seedlings , whereas high binding activity was detectable with extracts from tissues with high AtpC expression levels , i . e . extracts from light - grown seedlings and etiolated seedlings treated with cytokinin .", + "entities": [ + "CBF", + "wild - type AtpC promoter sequence", + "AtpC", + "AtpC", + "cytokinin" + ] + }, + { + "id": "8943", + "type": "gene", + "text": "Deletion mapping experiments determined that the sequences required for full activity in MSC - 1 cells were included within 619 bp of the start site and identified several regions that demonstrated increased luciferase activity : the - 583 bp to - 564 bp , - 503 bp to - 484 bp , and - 114 bp to - 65 regions .", + "entities": [ + "luciferase" + ] + }, + { + "id": "8944", + "type": "gene", + "text": "Before turnout , a morantel sustained release bolus ( MSRB ) was administered to each animal in the \" treated \" category .", + "entities": [] + }, + { + "id": "8945", + "type": "gene", + "text": "Ceftazidime shows promise as single - agent therapy for serious gram - negative bacillary infections .", + "entities": [] + }, + { + "id": "8946", + "type": "gene", + "text": "Liu , B .", + "entities": [] + }, + { + "id": "8947", + "type": "gene", + "text": "To clarify whether seizure - offset patterns are reliable in predicting seizure outcome , we studied SEEG / ECoG in a similar group of patients with temporal lobe epilepsy ( TLE ) .", + "entities": [] + }, + { + "id": "8948", + "type": "gene", + "text": "Mutation of nucleotides adjacent to the AP - 1 cis - response elements had no effect on trans - activation .", + "entities": [ + "AP - 1 cis - response elements" + ] + }, + { + "id": "8949", + "type": "gene", + "text": "All lambs with B breeding had significantly higher Hb levels at the end of the experiment than did NB lambs .", + "entities": [ + "Hb" + ] + }, + { + "id": "8950", + "type": "gene", + "text": "b and S x B lambs had higher ( P < . 05 ) Hb levels than the D x B lambs , and B lambs had the highest ( P < . 05 ) mean corpuscular hemoglobin concentrations .", + "entities": [ + "Hb", + "hemoglobin" + ] + }, + { + "id": "8951", + "type": "gene", + "text": "Additionally , observations that patients with mitral versus aortic regurgitation respond differently to valve replacement suggest that differences exist preoperatively between these two types of volume overload .", + "entities": [] + }, + { + "id": "8952", + "type": "gene", + "text": "All injections of CSF were given after the initiation of neutropenia and continued until the occurrence of an absolute neutrophil recovery .", + "entities": [ + "CSF" + ] + }, + { + "id": "8953", + "type": "gene", + "text": "rHu GM - CSF and rHu G - CSF , administered once daily at the 250 microg m ( - 2 ) day ( - 1 ) and 5 microg kg ( - 1 ) day ( - 1 ) level , were effective in increasing the absolute neutrophil count and neutrophil function , as measured by an automated chemiluminescence system .", + "entities": [ + "rHu GM - CSF", + "rHu G - CSF" + ] + }, + { + "id": "8954", + "type": "gene", + "text": "Gains increased 3 . 5 % ( P less than . 10 ) and feed conversion improved 5 . 9 % ( P less than . 07 ) in steers fed . 28 % AS - VFA compared with gain and feed conversion of the control steers .", + "entities": [] + }, + { + "id": "8955", + "type": "gene", + "text": "By contrast , mTRAP100 coprecipitates in vivo with another component of the TRAP complex ( TRAP220 ) , which directly contacts TR and the vitamin D receptor in a ligand - dependent manner .", + "entities": [ + "mTRAP100", + "TRAP complex", + "TRAP220", + "TR", + "vitamin D receptor" + ] + }, + { + "id": "8956", + "type": "gene", + "text": "This test should provide another practical means to study leprosy .", + "entities": [] + }, + { + "id": "8957", + "type": "gene", + "text": "In 12 cases ( 3 . 1 % ) , a change in stage resulted .", + "entities": [] + }, + { + "id": "8958", + "type": "gene", + "text": "In the context of the ADH2 upstream regulatory region , including UAS1 , working in concert with the ADH2 basal promoter elements , UAS2 - dependent gene activation was dependent on orientation , copy number , and helix phase .", + "entities": [ + "ADH2 upstream regulatory region", + "ADH2 basal promoter elements" + ] + }, + { + "id": "8959", + "type": "gene", + "text": "The ability of chronic UM - 272 ( dimethylpropranolol ) treatment to prevent the induction of reentrant ventricular tachyarrhythmias was assessed in the conscious dog subjected to serial programmed electrical stimulation on days 3 - - 5 after myocardial infarction .", + "entities": [] + }, + { + "id": "8960", + "type": "gene", + "text": "Therefore , in our in vitro model , the localization of the mutation in the K - ras gene predisposes to a different level of aggressiveness in the transforming phenotype .", + "entities": [ + "K - ras gene" + ] + }, + { + "id": "8961", + "type": "gene", + "text": "Patients underwent pretreatment cystoscopy and detailed tumor mapping , and were treated with 75 mg .", + "entities": [] + }, + { + "id": "8962", + "type": "gene", + "text": "/ m . 2 cisplatin on day 1 and 1 gm . / m . 2 daily , 5 - fluorouracil on days 1 to 4 and definitive radiotherapy .", + "entities": [] + }, + { + "id": "8963", + "type": "gene", + "text": "The results of these studies support a model in which VirB4 dimers or homomultimers contribute structural information for the assembly of a transenvelope channel competent for bidirectional DNA transfer , whereas an ATP - dependent activity is required for configuring this channel as a dedicated export machine .", + "entities": [ + "VirB4 dimers" + ] + }, + { + "id": "8964", + "type": "gene", + "text": "Regulation of the Raf kinase in T cells differs from findings with a variety of cell lines that the catalytic domain of Raf ( Raf ( delta26 - 303 ) ) shows no activity .", + "entities": [ + "Raf kinase", + "catalytic domain of Raf", + "Raf" + ] + }, + { + "id": "8965", + "type": "gene", + "text": "These results demonstrate a specific association of SIV and HIV - 2 nef , but not HIV - 1 nef , with TCRzeta .", + "entities": [ + "HIV - 2 nef", + "HIV - 1 nef", + "TCRzeta" + ] + }, + { + "id": "8966", + "type": "gene", + "text": "Randomly selected 300 children aged 3 months - 3 yr were analysed over a period of one year for estimating prevalence of nutritional anaemia .", + "entities": [] + }, + { + "id": "8967", + "type": "gene", + "text": "Comparison with alkaline phosphatases and 5 - nucleotidase", + "entities": [ + "alkaline phosphatases" + ] + }, + { + "id": "8968", + "type": "gene", + "text": "Their numbers have regularly increased since the mid - 1970s .", + "entities": [] + }, + { + "id": "8969", + "type": "gene", + "text": "We show here that RA and E1A induce phosphorylation of the E1A - associated 300 kDa protein ( p300 ) during the differentiation of F9 cells .", + "entities": [ + "E1A", + "E1A - associated 300 kDa protein", + "p300" + ] + }, + { + "id": "8970", + "type": "gene", + "text": "Mammalian ABPs and SHBGs bind sex steroids with high affinity , but some binding properties differ among species .", + "entities": [ + "Mammalian ABPs", + "SHBGs" + ] + }, + { + "id": "8971", + "type": "gene", + "text": "Subunit composition and domain structure of the Spo0A sporulation transcription factor of Bacillus subtilis .", + "entities": [ + "Spo0A sporulation transcription factor of Bacillus subtilis" + ] + }, + { + "id": "8972", + "type": "gene", + "text": "A method of three - station three - dimensional magnetic resonance ( MR ) angiography of the lower extremities with segmented volume acquisition is presented .", + "entities": [] + }, + { + "id": "8973", + "type": "gene", + "text": "The value of different sources of nitrogen in diets for the early - weaned calf .", + "entities": [] + }, + { + "id": "8974", + "type": "gene", + "text": "Vesicles could be induced only with multiple exposures to UVA .", + "entities": [] + }, + { + "id": "8975", + "type": "gene", + "text": "The pet56 and his3 genes are transcribed divergently from initiation sites that are separated by only 192 bp .", + "entities": [ + "pet56", + "his3 genes" + ] + }, + { + "id": "8976", + "type": "gene", + "text": "Neural - specific expression , genomic structure , and chromosomal localization of the gene encoding the zinc - finger transcription factor NGFI - C .", + "entities": [ + "zinc - finger transcription factor NGFI - C" + ] + }, + { + "id": "8977", + "type": "gene", + "text": "Modern cancer therapy has included surgery , radiotherapy , chemotherapy , and most recently , immunotherapy and hyperthermia .", + "entities": [] + }, + { + "id": "8978", + "type": "gene", + "text": "In several cell lines , mTOR or its downstream targets can be regulated by phosphatidylinositol ( PI ) 3 - kinase ; protein kinases A , B , and C ; heterotrimeric G - proteins ; a PD98059 - sensitive kinase or calcium ; as well as by amino acids .", + "entities": [ + "mTOR", + "phosphatidylinositol ( PI ) 3 - kinase", + "protein kinases A , B , and C", + "heterotrimeric G - proteins" + ] + }, + { + "id": "8979", + "type": "gene", + "text": "Pharmacodynamic studies on the cardiovascular system of spontaneously hypertensive rats .", + "entities": [] + }, + { + "id": "8980", + "type": "gene", + "text": "As pleural thickening is seen commonly in asbestosis and may influence lung volumes and the ratio of transfer factor to effective alveolar volume , the results of these measurements were compared only in the cases showing absent or minimal pleural thickening .", + "entities": [ + "transfer factor" + ] + }, + { + "id": "8981", + "type": "gene", + "text": "To determine the relationship of these viruses , the complete DNA sequence of KV consisting of 4754 bp was determined .", + "entities": [] + }, + { + "id": "8982", + "type": "gene", + "text": "The data support the notion that suppression of images during binocular rivalry is independent in both eyes .", + "entities": [] + }, + { + "id": "8983", + "type": "gene", + "text": "METHODS : Total muscle paralysis was induced under general anesthesia in a group of obese persons ( n = 9 ; body mass index , 32 + / - 3 kg [ - 2 ] ) and in a group of nonobese persons ( n = 9 ; body mas index , 21 + / - 2 kg [ - 2 ] ) .", + "entities": [] + }, + { + "id": "8984", + "type": "gene", + "text": "L - 735 , 524 free base or sulfate salt was administered orally as suspension , solution or in solid dosage forms to fasted or fed Beagle dogs .", + "entities": [] + }, + { + "id": "8985", + "type": "gene", + "text": "The concentration of PGI2 on the newly - formed luminal surface remained low .", + "entities": [] + }, + { + "id": "8986", + "type": "gene", + "text": "This GAP activity was observed in 3T3 - L1 adipocyte lysates , and was able to accelerate the hydrolysis of the [ alpha - 32P ] GTP bound to GST - Rab4 into [ alpha - 32P ] GDP .", + "entities": [ + "GAP", + "GST", + "Rab4" + ] + }, + { + "id": "8987", + "type": "gene", + "text": "The recommendation is made that specific sub - groups of attempters need to be identified and may warrant specialized intervention strategies .", + "entities": [] + }, + { + "id": "8988", + "type": "gene", + "text": "Protamine and heparin doses , their sum ( Sigma - dose ) and differential ( Delta - dose ) doses , and activated clotting times were tabulated .", + "entities": [ + "Protamine" + ] + }, + { + "id": "8989", + "type": "gene", + "text": "The Oct - 3 / 4 gene product , which belongs to the POU family of transcription factors , is a good candidate for regulating initial differentiation decisions .", + "entities": [ + "Oct - 3 / 4 gene product", + "POU family of transcription factors" + ] + }, + { + "id": "8990", + "type": "gene", + "text": "Mutation analyses identified the cobalt - responsive sequences as the stress - response elements ( StREs ) .", + "entities": [] + }, + { + "id": "8991", + "type": "gene", + "text": "An extensive inverted repeat is present 3 ' of rpeA ; inverted repeats are found downstream of all PE operons sequenced to date , although the sequence is not conserved .", + "entities": [ + "rpeA", + "PE operons" + ] + }, + { + "id": "8992", + "type": "gene", + "text": "To define the mechanism responsible for the loss of transcription elongation blockage and resulting c - myc deregulation in Burkitt ' s lymphoma , we analyzed transcription patterns after transfer of normal and Burkitt ' s lymphoma c - myc alleles into murine cells and Xenopus oocyte germinal vesicles .", + "entities": [ + "c - myc", + "c - myc" + ] + }, + { + "id": "8993", + "type": "gene", + "text": "Bilateral Charnley arthroplasty as a single procedure .", + "entities": [] + }, + { + "id": "8994", + "type": "gene", + "text": "The first exon ( exon 1A ) that corresponded to the 5 ' - untranslated region of the GHR 1A mRNA was 15 , 250 bp upstream from exon 2 in the GHR gene .", + "entities": [ + "GHR 1A mRNA", + "GHR gene" + ] + }, + { + "id": "8995", + "type": "gene", + "text": "A case of chronic hepatitis C with primary hypothyroidism manifested during interferon treatment", + "entities": [ + "interferon" + ] + }, + { + "id": "8996", + "type": "gene", + "text": "The promoter activity of the gene encoding Alzheimer beta - amyloid precursor protein ( APP ) is regulated by two blocks of upstream sequences .", + "entities": [ + "gene encoding Alzheimer beta - amyloid precursor protein", + "APP" + ] + }, + { + "id": "8997", + "type": "gene", + "text": "Frequency of seeing curves were examined for the method most similar to FDT .", + "entities": [] + }, + { + "id": "8998", + "type": "gene", + "text": "SPP also induced transient tyrosine phosphorylation of focal adhesion kinase ( p125 ( FAK ) ) , a cytosolic tyrosine kinase that localizes in focal adhesions , and of the cytoskeleton - associated protein paxillin .", + "entities": [ + "SPP", + "focal adhesion kinase", + "p125", + "FAK", + "cytosolic tyrosine kinase", + "cytoskeleton - associated protein paxillin" + ] + }, + { + "id": "8999", + "type": "gene", + "text": "Therefore , with a biopsy from the stoma site there is a risk of missing early rejection .", + "entities": [] + }, + { + "id": "9000", + "type": "gene", + "text": "Variables evaluated were number of weekly anginal events , data from ergometric exercise testing with simultaneous electrocardiographic registration , semiquantitative evaluation of Tc - 99m 2 - methoxy isobutyl isonitrile ( MIBI ) scans and rheologic variables .", + "entities": [] + }, + { + "id": "9001", + "type": "gene", + "text": "L / H > 0 . 61 ( chi ( 2 ) = 10 . 8 ; P : < 0 . 001 ) and a restrictive filling pattern ( chi ( 2 ) = 3 . 6 ; P : < 0 . 05 ) were independent predictors of events .", + "entities": [] + }, + { + "id": "9002", + "type": "gene", + "text": "This work , therefore , also emphasizes the importance of careful choice of oligonucleotide and cDNA probes to study PKC zeta mRNA .", + "entities": [ + "PKC zeta mRNA" + ] + }, + { + "id": "9003", + "type": "gene", + "text": "Its neuromuscular effects are similar to a single ED90 dose of vecuronium .", + "entities": [] + }, + { + "id": "9004", + "type": "gene", + "text": "The 95 % confidence values ( 2SD ) for the change in Ros required to exclude natural variability were 0 . 39 , 0 . 50 and 0 . 53 cmH2O l - 1 s , respectively .", + "entities": [] + }, + { + "id": "9005", + "type": "gene", + "text": "Thioredoxin ( TR ) is a small ubiquitous dithiol - reductase enzyme first identified in bacteria and plants .", + "entities": [ + "Thioredoxin", + "TR", + "dithiol - reductase enzyme" + ] + }, + { + "id": "9006", + "type": "gene", + "text": "We determined how DNA repair is affected by TFA1 conditional mutations .", + "entities": [ + "TFA1" + ] + }, + { + "id": "9007", + "type": "gene", + "text": "To accomplish this , actin cables and patches are redistributed during the cell cycle to direct secretory components to appropriate sites for cell growth .", + "entities": [ + "actin" + ] + }, + { + "id": "9008", + "type": "gene", + "text": "Because of its wide spectrum of activity particularly against ampicillin resistant strains of H . influenzae and because of its good tolerance Cefaclor is very useful in treatment of respiratory tract infections in children .", + "entities": [] + }, + { + "id": "9009", + "type": "gene", + "text": "Six healthy male subjects received single oral doses of regular release ( RR ) quinidine sulfate , sustained release ( SR ) quinidine bisulfate and the same dose of the SR product with food ( SR - F ) .", + "entities": [] + }, + { + "id": "9010", + "type": "gene", + "text": "Lysozyme activity was evidently increased as well in undiluted as in diluted sera in all our tested patients .", + "entities": [ + "Lysozyme" + ] + }, + { + "id": "9011", + "type": "gene", + "text": "Klebsiella oxytoca can assimilate nitrate and nitrite by using enzymes encoded by the nasFEDCBA operon .", + "entities": [ + "nasFEDCBA operon" + ] + }, + { + "id": "9012", + "type": "gene", + "text": "Interaction of the Fur repressor with a 150 - bp fragment encompassing the pvdS promoter was demonstrated in vivo by the Fur titration assay and confirmed in vitro by gel retardation experiments with a partially purified Fur preparation .", + "entities": [ + "Fur repressor", + "pvdS promoter", + "Fur", + "Fur" + ] + }, + { + "id": "9013", + "type": "gene", + "text": "In the unclipped group arterial pressure decreased 50 mmHg to normal by 24 h and was associated with increased diuresis and a small decrease in blood volume ( 9 . 8 % ) .", + "entities": [] + }, + { + "id": "9014", + "type": "gene", + "text": "A 13 base - pair oligonucleotide spanning nucleotides + 80 to + 92 of the 5 S RNA gene retained specific and high - affinity binding , although the latter was reduced sixfold relative to longer DNA fragments .", + "entities": [ + "5 S RNA gene" + ] + }, + { + "id": "9015", + "type": "gene", + "text": "Pulmonary vein varix in association with bilateral pulmonary vein stenosis .", + "entities": [] + }, + { + "id": "9016", + "type": "gene", + "text": "The cAMP - dependent mitogenic pathway is unique as it is independent of mitogen - activated protein kinase activation and differs from growth factor - dependent pathways at the level of the expression of several protooncogenes / transcription factors .", + "entities": [ + "mitogen - activated protein kinase" + ] + }, + { + "id": "9017", + "type": "gene", + "text": "Also , the anti - inflammatory activities of an aqueous extract of Buddleia cordata and its principal glycoside linarin were evaluated .", + "entities": [] + }, + { + "id": "9018", + "type": "gene", + "text": "These findings indicate that hypergastrinemia induced by surgical removal of acid - producing mucosa in the rat has the same effects on oxyntical mucosal HDC activity , histamine concentration and ECL cell density as hypergastrinemia induced by continuous gastrin infusion or by long - term treatment with effective antisecretagogues .", + "entities": [ + "mucosal HDC", + "gastrin" + ] + }, + { + "id": "9019", + "type": "gene", + "text": "Induction of the urokinase promoter by HGF / SF via the Met receptor was blocked by co - expression of a dominant - negative Grb2 and Sos1 expression construct .", + "entities": [ + "urokinase promoter", + "HGF", + "SF", + "Met receptor", + "Grb2", + "Sos1" + ] + }, + { + "id": "9020", + "type": "gene", + "text": "Improvement of the CRT display of an averager .", + "entities": [] + }, + { + "id": "9021", + "type": "gene", + "text": "Several authors have recently reported interference in theophylline analysis by paraxanthine ( 1 , 7 - dimethylxanthine ) , an important metabolite of caffeine .", + "entities": [] + }, + { + "id": "9022", + "type": "gene", + "text": "Susceptibilities of 540 anaerobic gram - negative bacilli to amoxicillin , amoxicillin - BRL 42715 , amoxicillin - clavulanate , temafloxacin , and clindamycin .", + "entities": [] + }, + { + "id": "9023", + "type": "gene", + "text": "Of these 179 samples , Mobiluncus SP was observed in 35 ( 19 . 6 % ) using Gram staining and in 18 ( 10 . 1 % ) this microorganism was isolated in agar RLK and anaerobic atmosphere .", + "entities": [] + }, + { + "id": "9024", + "type": "gene", + "text": "Local graft irradiation as an adjunct to pharmacologic immunosuppression .", + "entities": [] + }, + { + "id": "9025", + "type": "gene", + "text": "Copyright 2000 Academic Press .", + "entities": [] + }, + { + "id": "9026", + "type": "gene", + "text": "Supershift assays , using Jun and Fos family member - specific antibodies , showed that protein complexes formed by AtT - 20 cell nuclear extracts bound to the c - jun AP - 1 site were comprised of Jun family members , JunD , JunB , and cJun .", + "entities": [ + "Jun and Fos family member - specific antibodies", + "AP - 1 site", + "Jun", + "JunD", + "JunB", + "cJun" + ] + }, + { + "id": "9027", + "type": "gene", + "text": "Thus , our studies define Rac / Cdc42 / Pak as a module upstream of Raf - 1 during its activation by microtubule disruption .", + "entities": [ + "Rac", + "Cdc42", + "Pak", + "Raf - 1" + ] + }, + { + "id": "9028", + "type": "gene", + "text": "Blood sampling procedures were videotaped .", + "entities": [] + }, + { + "id": "9029", + "type": "gene", + "text": "The priming activity of DNA incised by either of the Drosophila enzymes can be enhanced , however , by an additional incubation with E . coli endonuclease IV , which is known to cleave depurinated DNA on the 5 ' - side of an apurinic site .", + "entities": [ + "E . coli endonuclease IV" + ] + }, + { + "id": "9030", + "type": "gene", + "text": "Ki - ras4BVal - 12 transfectant cells expressed 2 - fold elevated protein levels of the lysosomal cysteine protease cathepsin B but did not up - regulate cathepsin B mRNA expression .", + "entities": [ + "Ki - ras4BVal - 12", + "cathepsin B", + "cathepsin B mRNA" + ] + }, + { + "id": "9031", + "type": "gene", + "text": "Forty - five patients with pleural lesions identified on CT scans were subsequently examined by MR imaging at 0 . 5 T .", + "entities": [] + }, + { + "id": "9032", + "type": "gene", + "text": "These elements comprise a binding site for Krox proteins , one for nuclear factor 1 , an octamer motif that binds POU - homeodomain proteins , and a novel TN control element .", + "entities": [ + "Krox proteins", + "nuclear factor 1", + "POU - homeodomain proteins", + "TN control element" + ] + }, + { + "id": "9033", + "type": "gene", + "text": "According to the biochemical tests , high activity ( over 200 U / l ) of alkaline phosphatase was recorded exclusively in patients with the lymphogranulomatosis - induced liver damage .", + "entities": [ + "alkaline phosphatase" + ] + }, + { + "id": "9034", + "type": "gene", + "text": "Currently , the clinical use of 5 - aminolaevulinic acid ( ALA ) induced protoporphyrin IX ( PPIX ) for photodynamic therapy ( PDT ) is limited by the maximum tolerated oral ALA dose ( 60 mg / kg ) .", + "entities": [ + "protoporphyrin IX", + "PPIX" + ] + }, + { + "id": "9035", + "type": "gene", + "text": "A second domain , located in the C - terminal 437 amino acids of IE1 , is required for inhibitory and DNA - binding activities .", + "entities": [ + "IE1" + ] + }, + { + "id": "9036", + "type": "gene", + "text": "The term endovascular papillary haemangioma is suggested .", + "entities": [] + }, + { + "id": "9037", + "type": "gene", + "text": "In HeLa x fibroblast cell hybrids its expression correlates with tumorigenicity .", + "entities": [] + }, + { + "id": "9038", + "type": "gene", + "text": "Mutational analysis of yeast CEG1 demonstrated that four of the five conserved motifs are essential for capping enzyme function in vivo .", + "entities": [ + "yeast CEG1", + "capping enzyme" + ] + }, + { + "id": "9039", + "type": "gene", + "text": "More importantly , this fusion converted a less effective vaccine into one with significant potency against established E7 - expressing metastatic tumors .", + "entities": [ + "E7" + ] + }, + { + "id": "9040", + "type": "gene", + "text": "Iron and folate deficiency in pregnancy", + "entities": [] + }, + { + "id": "9041", + "type": "gene", + "text": "The fission yeast dsk1 + gene , a multicopy suppressor for cold - sensitive dis1 mutants , encodes a novel 61 - kd protein kinase .", + "entities": [ + "fission yeast dsk1 + gene", + "dis1 mutants" + ] + }, + { + "id": "9042", + "type": "gene", + "text": "Taken together , our data indicate that multiple survival pathways are triggered via this receptor , whereas NF - kappaB / Rel and PI - 3K are crucial for CD40 - induced proliferation .", + "entities": [ + "NF - kappaB", + "Rel", + "PI - 3K", + "CD40" + ] + }, + { + "id": "9043", + "type": "gene", + "text": "Coimmunoprecipitation experiments performed in transfected cells showed that BCMA associates with TNFR - associated factor ( TRAF ) 1 , TRAF2 , and TRAF3 adaptor proteins .", + "entities": [ + "BCMA", + "TNFR - associated factor ( TRAF ) 1", + "TRAF2", + "TRAF3 adaptor proteins" + ] + }, + { + "id": "9044", + "type": "gene", + "text": "Gastrin secretion during food stimulation in digestive system diseases", + "entities": [ + "Gastrin" + ] + }, + { + "id": "9045", + "type": "gene", + "text": "For E2 , each cat was given either 5 ( group [ G ] 1 ) or 10 ( G2 ) mg of itraconazole / kg ( capsules ) twice daily for 6 weeks .", + "entities": [] + }, + { + "id": "9046", + "type": "gene", + "text": "Phylogenetic analysis gave evidence for a close evolutionary relationship between PhHV - 1 and members of the Varicellovirus genus of the alpha - Herpesvirinae and canid herpesvirus in particular .", + "entities": [] + }, + { + "id": "9047", + "type": "gene", + "text": "11 - Aminoundecanoyl - SK - NH2 and 11 - aminoundecanoyl - SH - NH2 establish that a simple alkyl backbone can maintain an appropriate distance between three elements critical for recognition by the fungal enzyme ' s peptide - binding site : a simple omega - terminal amino group , a beta - hydroxyl , and an epsilon - amino group or an imidazole .", + "entities": [] + }, + { + "id": "9048", + "type": "gene", + "text": "B cell antigen receptor ( BCR ) - mediated formation of a SHP - 2 - pp120 complex and its inhibition by Fc gamma RIIB1 - BCR coligation .", + "entities": [ + "B cell antigen receptor", + "BCR", + "SHP - 2", + "pp120", + "Fc gamma RIIB1", + "BCR" + ] + }, + { + "id": "9049", + "type": "gene", + "text": "Anti - HBc production of PBMC was enhanced remarkably in this case .", + "entities": [ + "Anti - HBc" + ] + }, + { + "id": "9050", + "type": "gene", + "text": "Separate experiments measured AIB and 86RbCl uptake in 36B - 10 cells in vitro 1 and 2 days following 20 Gy irradiation to assess whether this radiation dose reduced the capacity of tumor cells to trap AIB or Rb + .", + "entities": [] + }, + { + "id": "9051", + "type": "gene", + "text": "An 8 - bp sequence ( ATTTCAAA ) within the protected region shares significant homology with promoter sequences required for ethylene responsiveness from the tomato fruit - ripening E4 gene .", + "entities": [ + "E4 gene" + ] + }, + { + "id": "9052", + "type": "gene", + "text": "The effect of independent predictors on survival was examined in a Cox regression model with adjustment for existing illnesses .", + "entities": [] + }, + { + "id": "9053", + "type": "gene", + "text": "Growth factor stimulation of cells causes the phosphorylation of the c - Myc transcriptional activation domain at Ser62 within a proline - rich region that is highly conserved among members of the Myc family ( Alvarez , E . , Northwood , I . C . , Gonzalez , F .", + "entities": [ + "c - Myc transcriptional activation domain", + "Myc family" + ] + }, + { + "id": "9054", + "type": "gene", + "text": "The translation products of both clones are highly homologous to APS1 ( 66 and 86 % identity , respectively ) over their entire lengths , including amino terminal sequences resembling transit peptides for plastid localization .", + "entities": [ + "APS1" + ] + }, + { + "id": "9055", + "type": "gene", + "text": "These results continue to support the hypothesis that HS2 , HS3 , and HS4 act as a single , integral unit to regulate human globin gene transcription as a holocomplex , but they can also be interpreted to say that formation of a DNase I hypersensitive holocomplex alone is not sufficient for mediating high - level globin gene transcription .", + "entities": [ + "human globin gene", + "DNase I", + "globin gene" + ] + }, + { + "id": "9056", + "type": "gene", + "text": "Interestingly , the RXRalphaF318A constitutive activity generated within heterodimers in the presence of BMS614 requires the integrity of both RXR and RAR AF - 2 domains .", + "entities": [ + "RXRalphaF318A", + "RXR", + "RAR" + ] + }, + { + "id": "9057", + "type": "gene", + "text": "Serum antibodies were detected in at least 95 % of the infected guinea pigs between 4 - 30 WPI and rats between 3 - 16 WPI .", + "entities": [] + }, + { + "id": "9058", + "type": "gene", + "text": "The addition of diatrizoate to the IPRK led to a dose - dependent biphasic change in RPF and GFR characterized by an initial transient increase followed by a marked and sustained decrease .", + "entities": [] + }, + { + "id": "9059", + "type": "gene", + "text": "The patient was treated with benzathine penicillin , 2 , 400 , 000 U weekly for three weeks .", + "entities": [] + }, + { + "id": "9060", + "type": "gene", + "text": "In contrast , the xtRNA ( Sec ) gene needs the binding of the seven Staf zinc fingers , but not Oct - 1 , for optimal transcriptional capacity .", + "entities": [ + "xtRNA", + "Sec", + "Staf zinc fingers", + "Oct - 1" + ] + }, + { + "id": "9061", + "type": "gene", + "text": "The levels of fibrinogen as well as antithrombin III ( ATIII ) and heparin cofactor II ( HCII ) activities were steadily increased in loop - bearing animals .", + "entities": [ + "fibrinogen", + "antithrombin III", + "ATIII", + "heparin cofactor II", + "HCII" + ] + }, + { + "id": "9062", + "type": "gene", + "text": "In contrast with the previously reported HMGR1 mRNA ( HMGR1S mRNA ) , which is detected at high levels in all tissues of the plant , HMGR1L mRNA is present at relatively low levels and its expression is restricted mostly to seedlings , roots and inflorescences .", + "entities": [ + "HMGR1 mRNA", + "HMGR1S mRNA", + "HMGR1L mRNA" + ] + }, + { + "id": "9063", + "type": "gene", + "text": "Smoking history and awake oxygen saturation ( SaO2 ) was recorded in all of them .", + "entities": [] + }, + { + "id": "9064", + "type": "gene", + "text": "NF - kappaB pathway activation occurs during transformation induced by a number of classical oncogenes , including Bcr / Abl , Ras and Rac , and is necessary for full transforming potential .", + "entities": [ + "NF - kappaB", + "Bcr", + "Abl", + "Ras", + "Rac" + ] + }, + { + "id": "9065", + "type": "gene", + "text": "Imposed angular displacements of monkey ' s wrist produce three major peaks of activity ( terms M1 , M2 , and M3 peaks ) in the averaged gross EMG activity ot the stretched muscles .", + "entities": [] + }, + { + "id": "9066", + "type": "gene", + "text": "These results indicate that both N - and C - terminal mutations are required to inhibit transrepression by FBR protein and that multiple structural mutations accompanied by posttranslational protein modification alter gene regulation by FBR protein .", + "entities": [ + "FBR protein", + "FBR protein" + ] + }, + { + "id": "9067", + "type": "gene", + "text": "The proportion of the biopsies found to be seropositive for HBs antigen was 27 . 9 % , and these showed either MGN or MPGN pattern .", + "entities": [ + "HBs antigen" + ] + }, + { + "id": "9068", + "type": "gene", + "text": "Nephrotoxicity after orthotopic liver transplantation in cyclosporin A and FK 506 - treated patients .", + "entities": [] + }, + { + "id": "9069", + "type": "gene", + "text": "LPO and SOD levels were measured at five points before and during the operation .", + "entities": [ + "SOD" + ] + }, + { + "id": "9070", + "type": "gene", + "text": "The participants were homosexual men in hepatitis B vaccine trials in Amsterdam ( n = 74 ) , New York City ( n = 120 ) , and San Francisco ( n = 168 ) .", + "entities": [] + }, + { + "id": "9071", + "type": "gene", + "text": "Whereas the mutant enzymes terminate normally at the late terminator in T7 DNA ( T ( phi ) ) and rrnB T2 , they fail to terminate at one of the termination sites of rrnB T1 , and also fail to recognize the PTH and CJ signals .", + "entities": [ + "rrnB", + "rrnB", + "PTH" + ] + }, + { + "id": "9072", + "type": "gene", + "text": "The asymmetric methylation was associated with tissue - specific disruption of H19 genomic imprinting in fetal brain .", + "entities": [ + "H19" + ] + }, + { + "id": "9073", + "type": "gene", + "text": "The median durations for response and survival time in the late phase II trial were 2 . 3 months and 5 . 8 months , respectively .", + "entities": [] + }, + { + "id": "9074", + "type": "gene", + "text": "Recent application of recombinant canarypox ALVAC / HIV - 1 vectors as vaccine immunogens in HIV - 1 , - noninfected volunteers has produced CTL responses in a significant number of vaccinees .", + "entities": [] + }, + { + "id": "9075", + "type": "gene", + "text": "Martin Luther and his physicians .", + "entities": [] + }, + { + "id": "9076", + "type": "gene", + "text": "Structural changes in the kinetically more damaged E44D mutant detected in ( 1 ) H - ( 15 ) N HSQC spectra were largely limited to the loop I - helix I motif , suggesting that Glu - 44 stabilizes the active site region .", + "entities": [] + }, + { + "id": "9077", + "type": "gene", + "text": "Point mutations that suppressed the in vitro binding of NF - Y to the internal palindromic arm reduced the activity of the resident P4 promoter , while those preventing complex formation with USF did not , as determined by transient expression assays using the luciferase reporter gene .", + "entities": [ + "NF - Y", + "USF", + "luciferase" + ] + }, + { + "id": "9078", + "type": "gene", + "text": "The effect of antilymphocyte sera on formation of transplantation and anti - infection immunity in mice", + "entities": [] + }, + { + "id": "9079", + "type": "gene", + "text": "Recombinant , bacterially expressed PIP5KIalpha possessed PIP5K activity and was immunoreactive with erythroid PIP5KI antibodies .", + "entities": [ + "PIP5KIalpha", + "PIP5K", + "erythroid PIP5KI antibodies" + ] + }, + { + "id": "9080", + "type": "gene", + "text": "To explore the function of human SINA - homologous ( Siah ) proteins , expression plasmids encoding Siah - 1A were transiently transfected into 293 epithelial cells and GM701 fibroblast cells , resulting in growth arrest without induction of apoptosis .", + "entities": [ + "SINA - homologous ( Siah ) proteins", + "Siah - 1A" + ] + }, + { + "id": "9081", + "type": "gene", + "text": "This experiment was conducted to determine if the sex or actual egg production was the important factor . ( ABSTRACT TRUNCATED AT 250 WORDS )", + "entities": [] + }, + { + "id": "9082", + "type": "gene", + "text": "Our data provide a biochemical explanation for the similarity in phenotype between A - T and NBS .", + "entities": [] + }, + { + "id": "9083", + "type": "gene", + "text": "Velocity sedimentation , cross - linking , and immunoprecipitation analyses of detergent - solubilized rat brain revealed that the 32 and 34 kDa polypeptides reside within heterotetramers .", + "entities": [] + }, + { + "id": "9084", + "type": "gene", + "text": "In the TLE patients the NAA : Cr ratios were reduced in the seizure focus , while in the FLE patients they were not always reduced in the seizure focus .", + "entities": [] + }, + { + "id": "9085", + "type": "gene", + "text": "For Al , the exposure to 1 . 36 mg / m3 during the shift corresponded to a urinary concentration at the end of the shift of 200 microgram / g creatinine .", + "entities": [] + }, + { + "id": "9086", + "type": "gene", + "text": "Initial experience with a serotonin agonist .", + "entities": [] + }, + { + "id": "9087", + "type": "gene", + "text": "PKC - gamma , which is not present in keratinocytes , also induces involucrin gene expression in a TPA - independent manner , when introduced into SVHK cells .", + "entities": [ + "PKC - gamma", + "involucrin gene" + ] + }, + { + "id": "9088", + "type": "gene", + "text": "Recombinant human erythropoietin ( epoetin ) is approved to be administered by the intravenous ( i . v . ) or subcutaneous ( SC ) route .", + "entities": [ + "Recombinant human erythropoietin", + "epoetin" + ] + }, + { + "id": "9089", + "type": "gene", + "text": "The sixth nucleotide was bulged out to allow stacking of this U . G pair on the adjacent helical region .", + "entities": [] + }, + { + "id": "9090", + "type": "gene", + "text": "Decreased levels of alpha2 - antiplasmin were also observed in the mediastinum ( 0 . 50 versus 0 . 61 U / mL ; p < 0 . 05 ) .", + "entities": [ + "alpha2 - antiplasmin" + ] + }, + { + "id": "9091", + "type": "gene", + "text": "JPEG 53 , resulting in a compression ratio of 1 : 21 , does not compromise the diagnostic performance in general .", + "entities": [] + }, + { + "id": "9092", + "type": "gene", + "text": "Our results demonstrate that distinct cytoplasmic domains of these cytokine receptors elicit convergent signaling pathways and provide evidence that beta c and IL - 2R beta function as a complete signal transducer .", + "entities": [ + "beta c", + "IL - 2R beta" + ] + }, + { + "id": "9093", + "type": "gene", + "text": "A crucial transcription factor in this process is STAT6 , which binds to a specific DNA element upon cytokine activation .", + "entities": [ + "STAT6" + ] + }, + { + "id": "9094", + "type": "gene", + "text": "Linkage studies have shown locus heterogeneity with one TSC gene mapped to chromosome 9q34 and a second to 16p13 . 3 .", + "entities": [ + "TSC gene" + ] + }, + { + "id": "9095", + "type": "gene", + "text": "Six of them , NUC1 , PRP21 ( also called SPP91 ) , CDC6 , CRY2 , the gene encoding the ribosomal protein S24 and the gene coding for a hypothetical protein of 599 amino acids , have been sequenced previously .", + "entities": [ + "NUC1", + "PRP21", + "SPP91", + "CDC6", + "CRY2", + "ribosomal protein S24" + ] + }, + { + "id": "9096", + "type": "gene", + "text": "Cortical afferents to the entorhinal cortex of the Rhesus monkey .", + "entities": [] + }, + { + "id": "9097", + "type": "gene", + "text": "Intraoperatively the complement factor C3c decreased by 20 % , while alpha 1 - antitrypsin showed postoperatively an increase by 30 % .", + "entities": [ + "complement factor C3c", + "alpha 1 - antitrypsin" + ] + }, + { + "id": "9098", + "type": "gene", + "text": "The response of serum GH to arginine infusion was normal , while that to insulin - induced hypoglycemia was poor .", + "entities": [ + "serum GH", + "insulin" + ] + }, + { + "id": "9099", + "type": "gene", + "text": "As stands shifted in dominance from pine to fir with age , subalpine fir appeared to maintain gradually increasing rates of whole - forest productivity until stands were approximately 400 years old .", + "entities": [] + }, + { + "id": "9100", + "type": "gene", + "text": "A clinical , serological and prognostic study", + "entities": [] + }, + { + "id": "9101", + "type": "gene", + "text": "In epithelial cells , the PH domain of Akt / PKB localised to sites of cell - cell and cell - matrix contact , distinct from focal contacts , even in the absence of serum .", + "entities": [ + "PH domain", + "Akt", + "PKB" + ] + }, + { + "id": "9102", + "type": "gene", + "text": "Gemfibrozil in hyperlipidaemic patients with peripheral arterial disease : some undiscovered actions .", + "entities": [] + }, + { + "id": "9103", + "type": "gene", + "text": "A - tracts functioned best when positioned close to the - 35 hexamer rather than one helical turn farther upstream , similar to the positioning optimal for UP element function .", + "entities": [] + }, + { + "id": "9104", + "type": "gene", + "text": "We have isolated cDNA clones from rat brain and human liver encoding a putative isoform of the Na , K - ATPase beta subunit .", + "entities": [ + "Na , K - ATPase beta subunit" + ] + }, + { + "id": "9105", + "type": "gene", + "text": "The symptoms and objective findings were caused by a malignant lymphoma , and the diagnosis was established from a drill biopsy .", + "entities": [] + }, + { + "id": "9106", + "type": "gene", + "text": "SSG1 , a gene encoding a sporulation - specific 1 , 3 - beta - glucanase in Saccharomyces cerevisiae .", + "entities": [ + "SSG1", + "sporulation - specific 1 , 3 - beta - glucanase" + ] + }, + { + "id": "9107", + "type": "gene", + "text": "Thus , cibenzoline is an effective antiarrhythmic agent with a favourable pharmacokinetic profile that may be considered with other class I drugs in patients requiring therapy for high risk arrhythmias .", + "entities": [] + }, + { + "id": "9108", + "type": "gene", + "text": "Optimal activation of T cells requires at least two signals .", + "entities": [] + }, + { + "id": "9109", + "type": "gene", + "text": "Sequence analysis of the zebrafish egr1 coding region revealed a high level of homology to the mouse , rat , and human Egr1 genes with the notable exception of a polymorphic , triplet nucleotide repeat sequence in the region coding for the amino terminus of the Egr1 protein .", + "entities": [ + "zebrafish egr1 coding region", + "human Egr1 genes", + "Egr1 protein" + ] + }, + { + "id": "9110", + "type": "gene", + "text": "A striking finding in all of the studies was a positive correlation between PI ACTH and MSH contents .", + "entities": [ + "ACTH", + "MSH" + ] + }, + { + "id": "9111", + "type": "gene", + "text": "A randomised , controlled trial was undertaken in 40 patients with active Crohn ' s disease to evaluate clinical and nutritional outcomes after an amino acid based diet containing 3 % fat was given by a feeding tube compared with a peptide based diet containing 33 % fat .", + "entities": [] + }, + { + "id": "9112", + "type": "gene", + "text": "In the absence of Swi4 and Swi6 cell viability is lost , but can be regained by ectopic expression of the G1 cyclin encoding genes , CLN1 or CLN2 .", + "entities": [ + "Swi4", + "Swi6", + "G1 cyclin encoding genes", + "CLN1", + "CLN2" + ] + }, + { + "id": "9113", + "type": "gene", + "text": "Cardiovascular and adrenal medullo - sympathetic reactions to acute tobacco poisoning", + "entities": [] + }, + { + "id": "9114", + "type": "gene", + "text": "If no reply was received , telephone contact or home visits were made .", + "entities": [] + }, + { + "id": "9115", + "type": "gene", + "text": "A mutation in the 5 ' C2U4 repeat causes underaccumulation of snR13F , whereas mutations in the 3 ' C2U4 repeat cause the accumulation of two novel RNAs that migrate in the 500 - nt range .", + "entities": [ + "snR13F" + ] + }, + { + "id": "9116", + "type": "gene", + "text": "In conclusion , the disposition of venlafaxine and O - desmethylvenlafaxine is markedly altered in renal disease ; therefore dosage adjustment is warranted for patients with creatinine clearance values below 30 ml / min .", + "entities": [] + }, + { + "id": "9117", + "type": "gene", + "text": "A polymorphic dinucleotide ( GT / CA ) n repeat contained in the NHE5 cosmid was identified and developed into a microsatellite PCR marker .", + "entities": [] + }, + { + "id": "9118", + "type": "gene", + "text": "Study on re - establishment of ovulation after termination of sex - steroidal treatment - - compared with re - appearance of ovulation after abortion and premature delivery .", + "entities": [] + }, + { + "id": "9119", + "type": "gene", + "text": "This Tbx6 - subfamily gene is likely to participate in paraxial mesoderm formation and somitogenesis in human embryo .", + "entities": [ + "Tbx6 - subfamily gene" + ] + }, + { + "id": "9120", + "type": "gene", + "text": "Thus , in T47D breast carcinoma cells , IL - 6 acts in synergy with EGF receptor autocrine activity to signal through the MAPK / PI3K pathways .", + "entities": [ + "IL - 6", + "EGF receptor", + "MAPK", + "PI3K" + ] + }, + { + "id": "9121", + "type": "gene", + "text": "Also , small , sense and antisense approximately 22 nt RNAs , derived from the satRNA , were associated with the replicating satellite .", + "entities": [] + }, + { + "id": "9122", + "type": "gene", + "text": "The first gene , NSR1 , a previously identified gene , encodes a protein involved in ribosomal RNA maturation and possibly in transport of proteins into the nucleus .", + "entities": [ + "NSR1" + ] + }, + { + "id": "9123", + "type": "gene", + "text": "Mechanism in the sequential control of cell morphology and S phase entry by epidermal growth factor involves distinct MEK / ERK activations .", + "entities": [ + "epidermal growth factor", + "MEK", + "ERK" + ] + }, + { + "id": "9124", + "type": "gene", + "text": "Mycobacterium avium - intracellulare complex infections in the acquired immunodeficiency syndrome .", + "entities": [] + }, + { + "id": "9125", + "type": "gene", + "text": "EMSA showed that nuclear proteins from PC12 but not C6 or Rat2 cells bind the CRE as a complex containing activating transcription factor ( ATF ) - 4 and CCAAT enhancer - binding protein beta , while both PC12 and C6 cell nuclear extracts were recruited by the CCAAT - box as a complex containing nuclear factor Y .", + "entities": [ + "activating transcription factor ( ATF ) - 4", + "CCAAT enhancer - binding protein beta", + "nuclear factor Y" + ] + }, + { + "id": "9126", + "type": "gene", + "text": "Expression of Msp was toxic to E . coli when the entire msp gene was present .", + "entities": [ + "Msp", + "msp gene" + ] + }, + { + "id": "9127", + "type": "gene", + "text": "All nuclear receptors have several well - characterized structural domains , including a conserved DNA - binding domain , and a ligand binding domain at the carboxyl terminus of the receptor .", + "entities": [] + }, + { + "id": "9128", + "type": "gene", + "text": "Substrates include the p21 ( ras ) proteins , nuclear lamins , and a series of retinal proteins .", + "entities": [ + "p21", + "ras", + "nuclear lamins" + ] + }, + { + "id": "9129", + "type": "gene", + "text": "1 - ( m - Chlorophenyl ) piperazine ( mCPP , 0 . 1 - 3 . 0 mg / kg ) and 1 - ( m - trifluoromethylphenyl ) piperazine ( TFMPP , 0 . 1 - 3 . 0 mg / kg ) , both thought to act primarily at 5 - HT1 sites , also decreased responding and this effect was blocked by methysergide and by 1 - NP , but not by ketanserin .", + "entities": [ + "5 - HT1 sites" + ] + }, + { + "id": "9130", + "type": "gene", + "text": "Isolated Systolic Hypertension : An Update .", + "entities": [] + }, + { + "id": "9131", + "type": "gene", + "text": "The less - polar mycolic acid - containing Rhodococcus species showed chromatographic patterns that partially overlapped ( in elution times ) the patterns of Nocardia asteroides , N . otitidiscaviarum , and N . brasiliensis , but the larger number of peaks in the last species made separation between the genera possible .", + "entities": [] + }, + { + "id": "9132", + "type": "gene", + "text": "Transfection of HepG2 and SK - N - MC cells with constructs deleted of additional 5 ' - flanking fragments permitted the definition of a minimal 200 bp promoter fragment containing the pseudo - TATA box and two putative SP1 - binding sites .", + "entities": [ + "SP1 - binding sites" + ] + }, + { + "id": "9133", + "type": "gene", + "text": "The control group revealed significantly higher levels of coagulation factors II , V and VIII , compared to the index group .", + "entities": [ + "coagulation factors II , V and VIII" + ] + }, + { + "id": "9134", + "type": "gene", + "text": "Gastritis score was significantly lower in nod - / CagA - children than in nod + / CagA - ( p = . 004 ) , nod - / CagA + ( p = . 002 ) and nod + / CagA + ( p < . 001 ) , both in the antrum and corpus .", + "entities": [ + "CagA", + "CagA", + "CagA", + "CagA" + ] + }, + { + "id": "9135", + "type": "gene", + "text": "Transcriptional blockade was reversed by co - transfections of a wild - type SRF expression vector , but was not rescued by the expression of other myogenic factors , such as MyoD and Mef - 2C .", + "entities": [ + "wild - type SRF", + "MyoD", + "Mef - 2C" + ] + }, + { + "id": "9136", + "type": "gene", + "text": "In conclusion , changes in carotid sinus stimulation alters blood flow to the hindlimb through changes in both Pcrit and Ra .", + "entities": [] + }, + { + "id": "9137", + "type": "gene", + "text": "Gel - shift assays with nuclear extracts and oligonucleotide sequences spanning the 0 . 125 - kb promoter region detected an ETS - immunoreactive complex , present most abundantly in cells overexpressing HER2 , whose high - affinity binding depended on the GAGGAA response element .", + "entities": [ + "ETS", + "HER2" + ] + }, + { + "id": "9138", + "type": "gene", + "text": "The genes encoding ( 2Fe - 2S ) plant - like ferredoxins were studied in the widely used cyanobacterium Synechocystis PCC6803 .", + "entities": [ + "( 2Fe - 2S ) plant - like ferredoxins" + ] + }, + { + "id": "9139", + "type": "gene", + "text": "Of 49 receptors which fired in phase with ventilation , 13 behaved like mammalian rapidly adapting pulmonary stretch receptors , 19 like mammalian slowly adapting pulmonary stretch receptors ( PSR ) , and 17 like avian intrapulmonary CO2 - sensitive chemoreceptors ( IPC ) .", + "entities": [] + }, + { + "id": "9140", + "type": "gene", + "text": "Preheparin LPL mass level did not significantly differ in individuals from 19 to 70 years old , for both men and women .", + "entities": [ + "LPL" + ] + }, + { + "id": "9141", + "type": "gene", + "text": "In summary , p56 ( lck ) activity stimulates G1 / S transition in immature thymoblasts and maintains cell viability via transduction of constitutive activation signals downstream to components of the Ras / Raf / MAPK pathway .", + "entities": [ + "p56", + "lck", + "Ras", + "Raf", + "MAPK" + ] + }, + { + "id": "9142", + "type": "gene", + "text": "However , its participation in collagen binding has not been shown .", + "entities": [ + "collagen" + ] + }, + { + "id": "9143", + "type": "gene", + "text": "TOR2 is part of two related signaling pathways coordinating cell growth in Saccharomyces cerevisiae .", + "entities": [ + "TOR2" + ] + }, + { + "id": "9144", + "type": "gene", + "text": "In mammals , the transcriptional repressors in the Wnt pathway are not well defined .", + "entities": [ + "Wnt" + ] + }, + { + "id": "9145", + "type": "gene", + "text": "Furthermore , the validity of this new subset of questions was shown to be significant ( r = 0 . 037 , p < 0 . 05 ) for the correlation between a measure of the severity of binocular visual field loss and the mean score of the variables used in the glaucoma specific subgroup of questions .", + "entities": [] + }, + { + "id": "9146", + "type": "gene", + "text": "The same - sized EBNA protein ( approximately 78 , 000 ) was made after transfection with BamHI - K ( 5 . 2 kilobase pairs [ kbp ] ) or the I1f subfragment ( 2 . 9 kbp ) .", + "entities": [ + "EBNA protein ( approximately 78 , 000 )", + "BamHI - K ( 5 . 2 kilobase pairs [ kbp ] )" + ] + }, + { + "id": "9147", + "type": "gene", + "text": "The PCr resynthesis rate ( P < 0 . 01 ) and the effective maximal rate of mitochondrial ATP synthesis ( P < 0 . 05 ) also improved .", + "entities": [] + }, + { + "id": "9148", + "type": "gene", + "text": "IdB 1031 was first extracted by liquid - solid partition and the extracts were evaporated and analysed on a reversed - phase column under isocratic conditions , using either an electrochemical or a UV detector .", + "entities": [] + }, + { + "id": "9149", + "type": "gene", + "text": "Treatment of PCC4 . aza1R cells with an RAR - selective agonist also repressed the expression of EC - 1 mRNA while treatment with an RXR - selective agonist reduced EC - 1 expression slightly .", + "entities": [ + "RAR", + "EC - 1 mRNA", + "RXR", + "EC - 1" + ] + }, + { + "id": "9150", + "type": "gene", + "text": "Efficient phosphorylation of BRDG1 by Tec required the PH and SH2 domains as well as the kinase domain of the latter .", + "entities": [ + "BRDG1", + "Tec", + "PH", + "SH2 domains" + ] + }, + { + "id": "9151", + "type": "gene", + "text": "We show , by injection of synthetic mRNAs , that the cis - acting sequences responsible for repression of cyclin B1 mRNA reside within its 3 ' UTR .", + "entities": [ + "cyclin B1 mRNA" + ] + }, + { + "id": "9152", + "type": "gene", + "text": "Since the stability of TF1 resides in its primary structure , we cloned a gene coding for TF1 , and the primary structure of the beta subunit was deduced from the nucleotide sequence of the gene to compare the sequence with those of beta ' s of three major categories of F1 ' s ; prokaryotic membranes , chloroplasts , and mitochondria .", + "entities": [ + "TF1", + "TF1", + "F1" + ] + }, + { + "id": "9153", + "type": "gene", + "text": "A short open reading frame ( ORF2 ) , of unknown function , is present in all FIV isolates .", + "entities": [] + }, + { + "id": "9154", + "type": "gene", + "text": "Valuing families : social work practice with families from a strengths perspective .", + "entities": [] + }, + { + "id": "9155", + "type": "gene", + "text": "Prospects for controlled - delivery systems .", + "entities": [] + }, + { + "id": "9156", + "type": "gene", + "text": "The role of neuroplasticity in the response to drugs .", + "entities": [] + }, + { + "id": "9157", + "type": "gene", + "text": "However , in those studies due to the presence of thiol agents in the PKC preparations , the sensitive reaction of BPO with redox - active cysteine residues in PKC was not observed .", + "entities": [ + "PKC", + "PKC" + ] + }, + { + "id": "9158", + "type": "gene", + "text": "From these results , we concluded that this ORF is the FRDS gene .", + "entities": [ + "FRDS gene" + ] + }, + { + "id": "9159", + "type": "gene", + "text": "Recessive lethal mutations were isolated based upon failure to complement the recessive lethality of Df ( 3L ) RR2 , a deletion of the DRE region that removes 16 - 18 polytene chromosome bands .", + "entities": [] + }, + { + "id": "9160", + "type": "gene", + "text": "To identify the important cis - DNA regulatory element ( s ) involved in the tissue - , region - , and cell - specific expression of the mE - RABP gene , the 5 - kb DNA fragment was sequenced .", + "entities": [ + "mE - RABP gene" + ] + }, + { + "id": "9161", + "type": "gene", + "text": "Endosonography accurately assessed tumor extension in two T2 tumors , 14 T3 tumors , and seven T4 tumors .", + "entities": [] + }, + { + "id": "9162", + "type": "gene", + "text": "The sequence of the pMxL1 plasmid containing the invertible region contains a perfect tandem repeat of 19 bp in the orientation 1 nonexpressed pilin gene at the middle of the recombination junction site .", + "entities": [ + "pilin gene" + ] + }, + { + "id": "9163", + "type": "gene", + "text": "The nucleosomal arrays detected by MPE X Fe ( II ) were characterized by a considerable loss of detail and significantly enhanced accessibility , the extent of which probably reflected the relative transcription rate of each gene .", + "entities": [] + }, + { + "id": "9164", + "type": "gene", + "text": "Rat liver catalase is sorted to peroxisomes by its C - terminal tripeptide Ala - Asn - Leu , not by the internal Ser - Lys - Leu motif .", + "entities": [ + "Rat liver catalase" + ] + }, + { + "id": "9165", + "type": "gene", + "text": "N - terminal sequence analysis and NMR measurements revealed that this fragment originates from the C - terminal 80 residues of MBF1 and form a well structured C - terminal domain of MBF1 , MBF1CTD .", + "entities": [ + "MBF1", + "MBF1", + "MBF1CTD" + ] + }, + { + "id": "9166", + "type": "gene", + "text": "Twenty food products were contaminated with V . cholerae O1 , Ogawa , toxigenic and not toxigenic strains : yoghurt , cream cheese , apricot marmelade , hip rose marmelade , mayonnaise , italian pasta for \" empanadas \" , \" dulce de leche \" , meat sausage , meat and spinach ravioli , margarine , milk dessert ( made with cocoa , milk confiture , starch and additives ) , lettuce , tuna fish , ricotta and sterilized milk .", + "entities": [] + }, + { + "id": "9167", + "type": "gene", + "text": "Bullous keratopathy was usually aphakic in origin in 1982 , but after 1983 pseudophakic bullous keratopathy ( PBK ) was the most common cause of bullous keratopathy .", + "entities": [] + }, + { + "id": "9168", + "type": "gene", + "text": "The por gene has been expressed , for the first time , in anaerobically grown Escherichia coli behind the isopropyl - beta - D - thiogalactopyranoside - inducible tac promoter , resulting in the production of POR in its active form .", + "entities": [ + "por gene", + "tac promoter", + "POR" + ] + }, + { + "id": "9169", + "type": "gene", + "text": "The interaction of caffeine , theophylline and theobromine with monoamine oxidase inhibitors .", + "entities": [ + "monoamine oxidase" + ] + }, + { + "id": "9170", + "type": "gene", + "text": "In the whole group of infected children , an age - specific z score < - 2 for weight and for FFM was significantly associated with an increased risk of death [ relative risk ( 95 % CI ) = 11 . 4 ( 3 . 1 , 41 . 0 ) and 5 . 1 ( 1 . 5 , 18 . 2 ) , respectively ] ; when only children with more severe disease were considered , only z score for weight was significantly associated with an increased risk [ 4 . 6 ( 1 . 4 , 14 . 9 ) ] .", + "entities": [] + }, + { + "id": "9171", + "type": "gene", + "text": "1972 .", + "entities": [] + }, + { + "id": "9172", + "type": "gene", + "text": "Two rare novel mutations , D811N in exon 20 and R835C in exon 21 , were identified in the first nucleotide - binding fold ( NBF ) , a functionally important region of SUR1 , in one patient each , both heterozygotes .", + "entities": [ + "SUR1" + ] + }, + { + "id": "9173", + "type": "gene", + "text": "There were 15 deaths , seven of which were felt to be avoidable .", + "entities": [] + }, + { + "id": "9174", + "type": "gene", + "text": "Since 1948 , the use of saline - washed red cells ( WRBCs ) has been advocated to minimize hemolysis after transfusion to patients with PNH .", + "entities": [] + }, + { + "id": "9175", + "type": "gene", + "text": "The alternative splice sites for the smallest adducin isoform , beta - 3 , are alternative donor and acceptor sites within exons 7 and 12 .", + "entities": [ + "adducin", + "beta - 3" + ] + }, + { + "id": "9176", + "type": "gene", + "text": "The ratio of the activity of arogenate dehydrogenase to that of prephenate dehydrogenase ( approximately 3 : 1 ) remained constant throughout purification , and the two activities were therefore inseparable .", + "entities": [ + "arogenate dehydrogenase", + "prephenate dehydrogenase" + ] + }, + { + "id": "9177", + "type": "gene", + "text": "Deletion analysis of the ICL1 promoter led to the identification of an upstream activating sequence element , UASICL1 ( 5 ' CATTCATCCG 3 ' ) , necessary and sufficient for conferring carbon source - dependent regulation on a heterologous reporter gene .", + "entities": [ + "ICL1 promoter" + ] + }, + { + "id": "9178", + "type": "gene", + "text": "Pneumothorax complicated by chronic steroid treatment .", + "entities": [] + }, + { + "id": "9179", + "type": "gene", + "text": "Elements that are fundamental to the safety evaluation of flavor ingredients include exposure , structural analogy , metabolism , pharmacokinetics and toxicology .", + "entities": [] + }, + { + "id": "9180", + "type": "gene", + "text": "A 7 - day treatment of amphotericin B ( 5 mg / kg / day i . p . ) significantly reduced the glomerular filtration rate ( GFR ) measured as inuline clearance and creatinine clearance ( 0 . 74 + / - 0 . 29 and 0 . 16 + / - 0 . 04 ml / min , respectively ) in comparison to vehicle - treated rats ( 2 . 04 + / - 0 . 23 and 1 . 29 + / - 0 . 19 ml / min , respectively ) .", + "entities": [] + }, + { + "id": "9181", + "type": "gene", + "text": "Taken together , they uphold the emerging concern that women with ER ( + ) cancers may not benefit significantly from endocrine treatment if the tumors also overexpress HER - 2 .", + "entities": [ + "ER ( + )", + "HER - 2" + ] + }, + { + "id": "9182", + "type": "gene", + "text": "The effect of Vpu on class I biogenesis was analyzed in more detail using a Vpu - expressing recombinant vaccinia virus ( VV ) .", + "entities": [ + "Vpu", + "Vpu" + ] + }, + { + "id": "9183", + "type": "gene", + "text": "The extent of the fbpA operator sequence ( 42 bp ) , as defined by our footprinting analysis , would suggest the binding of two Fur repressor dimers .", + "entities": [ + "fbpA operator sequence ( 42 bp )", + "Fur repressor dimers" + ] + }, + { + "id": "9184", + "type": "gene", + "text": "Liposomal Amphotericin - B failed in 6 / 7 patients with culture - proven mycosis who died from infection with Aspergillus ( n = 2 ) and Candida ( n = 4 ) , respectively .", + "entities": [] + }, + { + "id": "9185", + "type": "gene", + "text": "Lack of association between Kawasaki syndrome and infection with Rickettsia conorii , Rickettsia typhi , Coxiella burnetii or Ehrlichia phagocytophila group .", + "entities": [] + }, + { + "id": "9186", + "type": "gene", + "text": "Comparisons with the available amino acid residue ( aa ) sequence information from the complete CPMV RNA 1 sequence and the partial sequence of red clover mottle virus RNA 1 suggest that CPSMV RNA 1 specifies the expected set of five mature proteins : 32K proteinase cofactor , 58K presumed helicase , VPg 5 ' - linked protein of the genomic RNAs , 24K proteinase , and 87K presumed polymerase , separated by four cleavage sites .", + "entities": [ + "CPMV RNA 1 sequence", + "red clover mottle virus RNA 1", + "CPSMV RNA 1", + "32K proteinase cofactor", + "58K presumed helicase", + "VPg 5 ' - linked protein", + "24K proteinase", + "87K presumed polymerase" + ] + }, + { + "id": "9187", + "type": "gene", + "text": "The structural gene for hydrogenase encodes a protein product of molecular mass 45820 Da .", + "entities": [ + "hydrogenase" + ] + }, + { + "id": "9188", + "type": "gene", + "text": "Probable progressive multifocal leukoencephalopathy ( PML ) was diagnosed on the basis of clinical picture and magnetic resonance imaging in a 63 - year - old man with a complete remission of a non - Hodgkin ' s lymphoma .", + "entities": [] + }, + { + "id": "9189", + "type": "gene", + "text": "Cotransfection of the helicase - primase proteins , one of which was fused to a heterologous activation domain , led to Zta - dependent superactivation of CAT expression .", + "entities": [ + "helicase", + "primase", + "Zta", + "CAT" + ] + }, + { + "id": "9190", + "type": "gene", + "text": "Recently , an electrical - mechanical analog model of heat flow within the brain has been developed from which an expression for CBF has been derived : CBF = Cb / ( tau rho c ) where tau is the thermal decay constant , rho is the density of blood , and c is its specific heat .", + "entities": [] + }, + { + "id": "9191", + "type": "gene", + "text": "Plasma concentrations of atracurium and laudanosine were 0 . 73 - 3 . 11 micrograms ml - 1 and 0 . 48 - 8 . 65 micrograms ml - 1 , respectively ; CSF concentration of laudanosine was 70 - 440 ng ml - 1 .", + "entities": [] + }, + { + "id": "9192", + "type": "gene", + "text": "Subcellular localizations of the wild - type CBFbeta and the CBFbeta - SMMHC fusion protein were determined by immunofluorescence of NIH 3T3 cells that overexpress wild - type or fusion protein .", + "entities": [ + "wild - type CBFbeta", + "CBFbeta", + "SMMHC" + ] + }, + { + "id": "9193", + "type": "gene", + "text": "Prognosis in Bowen ' s disease localized to the ano - genital region .", + "entities": [] + }, + { + "id": "9194", + "type": "gene", + "text": "Chronic dose effects of methyl parathion on nuthatches : cholinesterase and ptilochronology .", + "entities": [ + "cholinesterase" + ] + }, + { + "id": "9195", + "type": "gene", + "text": "The data indicate that the five different ( and partially overlapping ) sry messenger RNAs detectable in early embryos are initiated at three separate sites , each directly upstream from one of the three protein - coding regions , designated ( in 5 ' to 3 ' order ) beta , alpha and delta .", + "entities": [ + "sry messenger RNAs" + ] + }, + { + "id": "9196", + "type": "gene", + "text": "Significance of thin glomerular basement membranes in hematuric children .", + "entities": [] + }, + { + "id": "9197", + "type": "gene", + "text": "Interestingly , one IRF binding site was found within the IRF - 2 promoter , and expression of the IRF - 2 gene was affected by both transient and stable IRF - 1 expression .", + "entities": [ + "IRF binding site", + "IRF - 2 promoter", + "IRF - 2 gene", + "IRF - 1" + ] + }, + { + "id": "9198", + "type": "gene", + "text": "Our laboratory and others have shown alternative splicing of up to ten exons at a discrete extracellular site to be primarily responsible for the generation of CD44 variant ( CD44v ) isoforms .", + "entities": [ + "CD44 variant", + "CD44v" + ] + }, + { + "id": "9199", + "type": "gene", + "text": "In visible tumours the best results were obtained with FB ( 85 % ) while TBN was positive in 65 % .", + "entities": [] + }, + { + "id": "9200", + "type": "gene", + "text": "Use of Medi - Jector EZ dermojet for anesthesia in minor surgery", + "entities": [] + }, + { + "id": "9201", + "type": "gene", + "text": "The second part of this paper shows some medical applications of these two aspects of NMR , with help of some examples , taken from the literature , according to what is concerned with endocrinology .", + "entities": [] + }, + { + "id": "9202", + "type": "gene", + "text": "The mRNA expression of RFX1 , RFX2 , and RFX3 was detected ubiquitously , but in transient - transfection assays , multimerized RFX binding sites in front of a basal promoter efficiently functioned in a tissue - and lineage - specific manner .", + "entities": [ + "RFX1", + "RFX2", + "RFX3", + "multimerized RFX binding sites" + ] + }, + { + "id": "9203", + "type": "gene", + "text": "A probe evoked potentials procedure was used to assess the relative engagement of both cerebral hemispheres during a language task in the following four groups of dextral adults : left hemisphere ( LH ) - damaged aphasics recovering from stroke , dysarthrics , right hemisphere ( RH ) - damaged nonaphasic patients , and normal control subjects .", + "entities": [] + }, + { + "id": "9204", + "type": "gene", + "text": "Preceptorship of CNS students : an exploratory study .", + "entities": [] + }, + { + "id": "9205", + "type": "gene", + "text": "The patients undergoing VTLB had significantly shorter operative times ( VTLB , 100 . 2 + / - 27 . 2 min . vs OLB , 119 . 8 + / - 42 . 6 min ; p < 0 . 01 ) and less blood loss ( VTLB , 4 . 7 + / - 14 . 6 ml vs OLB , 65 . 7 + / - 77 . 0 ml ; p < 0 . 001 ) .", + "entities": [] + }, + { + "id": "9206", + "type": "gene", + "text": "The relation between VE / VO2 and Q / VO2 showed a significant negative correlation ( r = - 0 . 93 , p less than 0 . 01 ) .", + "entities": [] + }, + { + "id": "9207", + "type": "gene", + "text": "Refined Cox models using a CD4 count of 150 / microL rather than 200 / microL to distinguish I0 and I1 yielded a simplified model with better fit to the observed data .", + "entities": [ + "CD4" + ] + }, + { + "id": "9208", + "type": "gene", + "text": "The only isolate of Aeromonas hydrophila produced cytotoxic enterotoxin and was invasive .", + "entities": [] + }, + { + "id": "9209", + "type": "gene", + "text": "The amount of drained effusion was measured , and fluid was sent for diagnostic assessment .", + "entities": [] + }, + { + "id": "9210", + "type": "gene", + "text": "Ischemia - induced biphasic arrhythmias were suppressed in both zatebradine and propranolol groups .", + "entities": [] + }, + { + "id": "9211", + "type": "gene", + "text": "The sequence was determined of 6493 nucleotides encompassing the bet genes of Escherichia coli which encode the osmoregulatory choline - glycine betaine pathway .", + "entities": [ + "bet genes of Escherichia coli" + ] + }, + { + "id": "9212", + "type": "gene", + "text": "Association with HL - A W - 27 .", + "entities": [ + "HL - A W - 27" + ] + }, + { + "id": "9213", + "type": "gene", + "text": "Experimental ischemic heart disease induced by thromboxane A2 in rabbits .", + "entities": [] + }, + { + "id": "9214", + "type": "gene", + "text": "This study demonstrates that inducible expression in response to either PMA or TPO is mediated through the Ets site in the proximal promoter of GPIX and is dependent upon the upstream activation of MAPK / extracellular signal - regulated kinase .", + "entities": [ + "TPO", + "Ets site", + "GPIX", + "MAPK", + "extracellular signal - regulated kinase" + ] + }, + { + "id": "9215", + "type": "gene", + "text": "Four p53 DNA - binding domain peptides bind natural p53 - response elements and bend the DNA .", + "entities": [ + "p53 DNA - binding domain peptides", + "p53 - response elements" + ] + }, + { + "id": "9216", + "type": "gene", + "text": "In the B6 - derived Db mutant B6 . CH - 2bm13 ( bm13 ) strain , part of the class I Db antigen - presenting groove is shaped by a class I Kb - encoded sequence .", + "entities": [ + "Db mutant B6 . CH - 2bm13 ( bm13 )", + "class I Db antigen - presenting groove", + "class I Kb - encoded sequence" + ] + }, + { + "id": "9217", + "type": "gene", + "text": "These data suggest that the combined treatment with a thromboxane synthetase inhibitor and a thromboxane receptor antagonist provides a better protection against digoxin intoxication than with either agent alone .", + "entities": [ + "thromboxane synthetase", + "thromboxane receptor" + ] + }, + { + "id": "9218", + "type": "gene", + "text": "The high level of transformation - associated deletions in the human YACs was reduced over 10 - fold when the host was a recombination - deficient strain deleted for the RAD52 gene .", + "entities": [ + "RAD52 gene" + ] + }, + { + "id": "9219", + "type": "gene", + "text": "ZEBRA and cellular AP - 1 bZip activators , such as c - Fos , have homologous DNA - binding domains , and their DNA - binding specificities overlap .", + "entities": [ + "ZEBRA", + "AP - 1 bZip activators", + "c - Fos" + ] + }, + { + "id": "9220", + "type": "gene", + "text": "Comparison of elastase - 1 with amylase , lipase , and trypsin - like immunoreactivity in the diagnosis of acute pancreatitis .", + "entities": [ + "elastase - 1", + "amylase", + "lipase", + "trypsin" + ] + }, + { + "id": "9221", + "type": "gene", + "text": "Analysis of several Tat mutants indicated that both the cysteine - rich and the core domains of this transactivator are necessary and sufficient to activate transcription when TBP is overexpressed .", + "entities": [ + "Tat mutants", + "TBP" + ] + }, + { + "id": "9222", + "type": "gene", + "text": "Here we show that IIIa pre - mRNA splicing is activated more than 200 - fold in nuclear extracts prepared from late adenovirus - infected cells ( Ad - NE ) compared to uninfected HeLa cell nuclear extracts ( HeLa - NE ) .", + "entities": [] + }, + { + "id": "9223", + "type": "gene", + "text": "We investigated the production of hyaluronan ( HA ) and its effect on cell motility in cells expressing the v - src mutants .", + "entities": [ + "v - src mutants" + ] + }, + { + "id": "9224", + "type": "gene", + "text": "Copyright 2002 American Cancer Society . DOI 10 . 1002 / cncr . 10318", + "entities": [] + }, + { + "id": "9225", + "type": "gene", + "text": "Two homologues of the rhombotin gene have now been isolated .", + "entities": [ + "rhombotin gene" + ] + }, + { + "id": "9226", + "type": "gene", + "text": "Previously , we identified a 51 - bp promoter fragment , oligo31 / 32 , which conferred heat shock inducibility on the heterologous CYC1 - lacZ reporter gene in S . cerevisiae ( N .", + "entities": [ + "CYC1", + "lacZ" + ] + }, + { + "id": "9227", + "type": "gene", + "text": "Its interaction with RFX5 and RFXAP is essential for binding of the RFX complex to MHC - II promoters .", + "entities": [ + "RFX5", + "RFXAP", + "RFX complex", + "MHC - II promoters" + ] + }, + { + "id": "9228", + "type": "gene", + "text": "No significant differences between the substituted and wild type peptides were observed , suggesting that this substitution in the intact protein may cause disruption of global rather than local structures .", + "entities": [] + }, + { + "id": "9229", + "type": "gene", + "text": "In 6 of 24 infants studied ( 27th - 40th weeks of gestation ) , acquired and congenital structural anomalies of the airways were detected with an ultrathin flexible fiberscope ( Olympus PF18 S , 1 . 8 mm ) .", + "entities": [] + }, + { + "id": "9230", + "type": "gene", + "text": "Expression , nucleotide sequence and mutational analysis of two open reading frames in the nif gene region of Anabaena sp . strain PCC7120 .", + "entities": [ + "nif gene region of Anabaena sp . strain PCC7120" + ] + }, + { + "id": "9231", + "type": "gene", + "text": "In literature , the HBE has been displayed by application of the averaging method .", + "entities": [] + }, + { + "id": "9232", + "type": "gene", + "text": "The Asian mouse Mus castaneus is resistant to infection by the polytropic mink cell focus - inducing ( MCF ) subgroup of murine leukemia viruses ( MuLVs ) .", + "entities": [] + }, + { + "id": "9233", + "type": "gene", + "text": "Ribonuclease protection assays revealed that hmg1 and hmg2 are differentially expressed in a developmentally - and spatially - modulated manner during morphogenesis of specialized terpenoid - containing pigment glands in embryos .", + "entities": [ + "hmg1", + "hmg2" + ] + }, + { + "id": "9234", + "type": "gene", + "text": "On the other hand , knowledge of the epidemiology of Parkinson ' s disease is necessary in creating etiological hypotheses , since only hypotheses consistent with the epidemiological profile deserve careful testing .", + "entities": [] + }, + { + "id": "9235", + "type": "gene", + "text": "We purified a Ca2 + / calmodulin ( CaM ) - dependent protein kinase ( CaM kinase ) from the yeast Saccharomyces cerevisiae with properties similar to mammalian type II CaM kinases .", + "entities": [ + "Ca2 + / calmodulin ( CaM ) - dependent protein kinase", + "CaM kinase", + "mammalian type II CaM kinases" + ] + }, + { + "id": "9236", + "type": "gene", + "text": "Members of the JAK / Tyk family of tyrosine kinases mediate phosphorylation of STAT3 at Tyr705 during CNTF signaling ; however , the kinase responsible for phosphorylation at STAT3 Tyr727 appears to depend on both the extracellular stimulus and the cellular context .", + "entities": [ + "JAK", + "Tyk", + "tyrosine kinases", + "STAT3", + "CNTF", + "STAT3" + ] + }, + { + "id": "9237", + "type": "gene", + "text": "Baseline data were obtained from 10 adults .", + "entities": [] + }, + { + "id": "9238", + "type": "gene", + "text": "Maternal p , p ' DDE and beta - HCH levels were also associated with newborn levels , but levels of PCBs were not .", + "entities": [] + }, + { + "id": "9239", + "type": "gene", + "text": "D . melanogaster HeT - A coding sequences have a polymorphic region with insertions / deletions of 1 - 31 codons and many nucleotide changes .", + "entities": [ + "HeT - A" + ] + }, + { + "id": "9240", + "type": "gene", + "text": "CD3 cross - linking induced tyrosine phosphorylation of Sam68 in uninfected T cells .", + "entities": [ + "CD3", + "Sam68" + ] + }, + { + "id": "9241", + "type": "gene", + "text": "Endoscopic examinations , peripheral white blood cell ( WBC ) counts , and assays of myeloperoxidase activity ( MPO ) in homogenates of colon mucosa were performed after one week ( 4 % DSS model ) and eight weeks ( 1 % DSS model ) .", + "entities": [ + "myeloperoxidase", + "MPO" + ] + }, + { + "id": "9242", + "type": "gene", + "text": "The protooncogene c - myb encodes a nuclear transcription factor that binds to DNA in a sequence - specific manner and transactivates transcription of several viral and cellular genes .", + "entities": [ + "c - myb" + ] + }, + { + "id": "9243", + "type": "gene", + "text": "PKNbeta had high sequence homology with PKNalpha , originally isolated PKN , especially in the repeats of charged amino acid - rich region with leucine - zipper like sequences ( CZ region / HR1 ) , in the carboxyl - terminal catalytic domain , and in approximately 130 amino acid stretch ( D region / HR2 ) , located between CZ region / HR1 and the catalytic domain .", + "entities": [ + "PKNbeta", + "PKNalpha", + "PKN" + ] + }, + { + "id": "9244", + "type": "gene", + "text": "We compare the results of this algorithm with the results obtained with two other algorithms , the optimal algorithm for monochannel nonoverlapping noise and the optimal algorithm for multichannel additive noise , and we show that in both cases improvement can be obtained .", + "entities": [] + }, + { + "id": "9245", + "type": "gene", + "text": "1 .", + "entities": [] + }, + { + "id": "9246", + "type": "gene", + "text": "Activation of c - fos gene expression by a kinase - deficient epidermal growth factor receptor .", + "entities": [ + "c - fos gene", + "epidermal growth factor receptor" + ] + }, + { + "id": "9247", + "type": "gene", + "text": "Indoor concentrations were only weakly correlated with outdoor concentrations , however , and personal exposures were even more poorly correlated with outdoor concentrations .", + "entities": [] + }, + { + "id": "9248", + "type": "gene", + "text": "This may result in more reabsorption and hence reduced renal clearance .", + "entities": [] + }, + { + "id": "9249", + "type": "gene", + "text": "Structural studies have shown that class I major histocompatibility complex ( MHC ) - restricted peptide - specific T cell receptor ( TCR ) - alpha / betas make multiple contacts with the alpha1 and alpha2 helices of the MHC , but it is unclear which or how many of these interactions contribute to functional binding .", + "entities": [ + "class I major histocompatibility complex", + "MHC", + "T cell receptor ( TCR ) - alpha / betas", + "MHC" + ] + }, + { + "id": "9250", + "type": "gene", + "text": "Greek classicism in living structure ?", + "entities": [] + }, + { + "id": "9251", + "type": "gene", + "text": "Some deductive pathways in animal morphology .", + "entities": [] + }, + { + "id": "9252", + "type": "gene", + "text": "SM is also shown to be associated in vivo with other components of the CRM 1 export pathway , including the small GTPase Ran and the nucleoporin CAN / Nup214 .", + "entities": [ + "SM", + "CRM 1", + "small GTPase Ran", + "CAN", + "Nup214" + ] + }, + { + "id": "9253", + "type": "gene", + "text": "The structure of digiprogenin .", + "entities": [] + }, + { + "id": "9254", + "type": "gene", + "text": "The PC - based RTPS is designed to run in the Microsoft Windows 3 . 11 environment ( and later versions ) , for computers equipped with 486 or Pentium processors .", + "entities": [] + }, + { + "id": "9255", + "type": "gene", + "text": "The QT interval was related to various components of the insulin resistance syndrome , including BP and insulin sensitivity .", + "entities": [ + "insulin", + "insulin" + ] + }, + { + "id": "9256", + "type": "gene", + "text": "Our results indicate that interaction between Jak2 and PRLR requires a proline - rich sequence in the membrane proximal region of the receptor , which is conserved among the different members of the cytokine receptor superfamily .", + "entities": [ + "Jak2", + "PRLR", + "cytokine receptor superfamily" + ] + }, + { + "id": "9257", + "type": "gene", + "text": "Necrosis appears 6 h after TA infusion , being 5 . 77 % in extent after 12 h , 14 . 9 % after 24 h and animals die with an area of 29 . 5 % necrosis .", + "entities": [] + }, + { + "id": "9258", + "type": "gene", + "text": "For SMX at pH 7 . 0 , a 1 : 1 complex is formed , but at pH 7 . 5 HPCD has little effect on the solubility of the highly ionized SMX , presumably since only un - ionized molecules can form inclusion complexes with the HPCD .", + "entities": [] + }, + { + "id": "9259", + "type": "gene", + "text": "Here we demonstrate that AML1a , which solely has no effects as a transcriptional regulator , dominantly suppresses transcriptional activation by AML1b , and that AML1a exhibits the higher affinity for DNA - binding than AML1b .", + "entities": [ + "AML1a", + "AML1b", + "AML1a", + "AML1b" + ] + }, + { + "id": "9260", + "type": "gene", + "text": "Control experiments showed that each fusion protein had a high affinity binding site for estradiol - 17 beta and could transactivate an ERE - LacZ reporter gene in yeast similar to the wild type ER .", + "entities": [ + "LacZ", + "wild type ER" + ] + }, + { + "id": "9261", + "type": "gene", + "text": "Lactation of baboons fed a low protein maintenance diet .", + "entities": [] + }, + { + "id": "9262", + "type": "gene", + "text": "Management of hypertension in the elderly .", + "entities": [] + }, + { + "id": "9263", + "type": "gene", + "text": "The Laser Scanning Ophthalmoscope enables a fundus - based examination and therefore allows exact comparison between morphologic appearance and corresponding function .", + "entities": [] + }, + { + "id": "9264", + "type": "gene", + "text": "In addition to protein binding at sequences known to be involved in the regulation of transcription , genomic footprinting of the entire promoter region also showed that a protein factor is constitutively bound to the first intron of the rep3 gene .", + "entities": [ + "rep3 gene" + ] + }, + { + "id": "9265", + "type": "gene", + "text": "On the character of changes in the enzyme activity in the brain tissue during reflex epilepsy", + "entities": [] + }, + { + "id": "9266", + "type": "gene", + "text": "Depth - controlled grazing - incidence diffraction of synchrotron x radiation .", + "entities": [] + }, + { + "id": "9267", + "type": "gene", + "text": "RESULTS : A novel gene was cloned .", + "entities": [] + }, + { + "id": "9268", + "type": "gene", + "text": "Total cholesterol was measured in amniotic fluids collected at different stages of gestation .", + "entities": [] + }, + { + "id": "9269", + "type": "gene", + "text": "This laser provided sufficient power in an amniotic fluid medium to occlude placental vessels as large as 7 mm in diameter within 6 seconds at a power density of 2000 W / cm2 .", + "entities": [] + }, + { + "id": "9270", + "type": "gene", + "text": "They generated ca .", + "entities": [] + }, + { + "id": "9271", + "type": "gene", + "text": "Voluntary wheel running did not significantly increase estimated alanine or pyruvate Gneo or absolute glycerol Ra .", + "entities": [] + }, + { + "id": "9272", + "type": "gene", + "text": "Dialyzable transfer factor .", + "entities": [ + "transfer factor" + ] + }, + { + "id": "9273", + "type": "gene", + "text": "From day 30 after turnout , the PFB - group had significantly lower serum pepsinogen levels , which reflects the low degree of abomasal damage in these animals .", + "entities": [ + "serum pepsinogen" + ] + }, + { + "id": "9274", + "type": "gene", + "text": "A medical - geographical review", + "entities": [] + }, + { + "id": "9275", + "type": "gene", + "text": "Telomerase is a ribonucleoprotein complex that synthesizes telomeric DNA onto chromosomes using its RNA component as template .", + "entities": [ + "Telomerase" + ] + }, + { + "id": "9276", + "type": "gene", + "text": "Fufang wuzi yanzong pills have strong leukogenic effect on cyclophosphamide induced leukopenia in mice .", + "entities": [] + }, + { + "id": "9277", + "type": "gene", + "text": "Activity of acid hydrolases of peripheral blood leukocytes in focal and segmental pneumonia in children", + "entities": [ + "acid hydrolases" + ] + }, + { + "id": "9278", + "type": "gene", + "text": "Forty - five cases were surgically by direct approach to the tumour , while two cases were treated only with a shunt .", + "entities": [] + }, + { + "id": "9279", + "type": "gene", + "text": "The incidence of second malignant neoplasms was lower ( 1 . 3 % ) in the group treated with 5 - fluorouracil , doxorubicin , and cyclophosphamide than in the historical control group ( 4 . 8 % ) .", + "entities": [] + }, + { + "id": "9280", + "type": "gene", + "text": "Because all PDGFbetaR fusions described thus far result in splicing to a common exon of this gene , we performed 5 ' - rapid amplification of cDNA ends PCR on patient RNA .", + "entities": [ + "PDGFbetaR fusions" + ] + }, + { + "id": "9281", + "type": "gene", + "text": "The characteristics of the VirD1 / VirD2 - mediated cleavage reaction strongly resemble those observed with relaxosomes of IncP plasmids involved in initiation of transfer DNA replication during bacterial conjugation .", + "entities": [ + "VirD1", + "VirD2" + ] + }, + { + "id": "9282", + "type": "gene", + "text": "Sestamibi scintigraphy , performed in 70 patients , was less sensitive than ultrasonography ( 80 % ) .", + "entities": [] + }, + { + "id": "9283", + "type": "gene", + "text": "A specific distal promoter controls gamma - glutamyl transpeptidase gene expression in undifferentiated rat transformed liver cells .", + "entities": [ + "gamma - glutamyl transpeptidase gene" + ] + }, + { + "id": "9284", + "type": "gene", + "text": "The UBA domains of RAD23 and DDI1 are required for these interactions .", + "entities": [ + "UBA domains", + "RAD23", + "DDI1" + ] + }, + { + "id": "9285", + "type": "gene", + "text": "This protein , designated p532 based on its predicted molecular weight ( EMBO J 15 : 5738 , 1996 ) , contains multiple structural domains including two regions of seven internal repeats highly related to the cell cycle regulator RCC1 , a guanine nucleotide exchange factor for the small GTP - binding protein Ran , seven beta - repeat domains characteristic of the beta subunit of heterotrimeric G proteins , three putative SH3 binding sites , a putative leucine - zipper and a carboxy - terminal HECT domain characteristic of E3 ubiquitin - protein ligases .", + "entities": [ + "p532", + "RCC1", + "guanine nucleotide exchange factor", + "Ran", + "heterotrimeric G proteins", + "SH3 binding sites", + "carboxy - terminal HECT domain", + "E3 ubiquitin - protein ligases" + ] + }, + { + "id": "9286", + "type": "gene", + "text": "In the control group the histological picture resembled osteoarthritis .", + "entities": [] + }, + { + "id": "9287", + "type": "gene", + "text": "Among 953 infants in 22 neonatal care units studied , 23 % ( median value , range 0 - 78 ) were found to be faecally colonized with one of 21 distinct nosocomial strains of Escherichia coli , Klebsiella or Enterobacter spp .", + "entities": [] + }, + { + "id": "9288", + "type": "gene", + "text": "Osteocalcin ( serum bone - Gla protein , sBGP ) , serum alkaline phosphatase ( sAP ) and urinary hydroxyproline / creatinine ratio ( uOH - Prol / creatinine ) have been measured in 21 patients with primary hyperparathyroidism ( PHPT ) and in nine patients with hypercalcaemia of malignancy ( HM ) .", + "entities": [ + "Osteocalcin", + "serum bone - Gla protein", + "sBGP", + "serum alkaline phosphatase", + "sAP" + ] + }, + { + "id": "9289", + "type": "gene", + "text": "The cDNAs cross - hybridize with genomic sequences in rat , human , and chicken DNA , but not with DNA from frog , Drosophila , or sea urchin .", + "entities": [] + }, + { + "id": "9290", + "type": "gene", + "text": "Nucleotide sequence and transcriptional analysis of the polyhedrin gene of Spodoptera exigua nuclear polyhedrosis virus .", + "entities": [ + "polyhedrin gene" + ] + }, + { + "id": "9291", + "type": "gene", + "text": "The iterative method proposed by Bengtsson [ Appl .", + "entities": [] + }, + { + "id": "9292", + "type": "gene", + "text": "Behcet ' s syndrome", + "entities": [] + }, + { + "id": "9293", + "type": "gene", + "text": "Changes of the DB sequence without affecting the postulated stem structure led to drastic losses of translation efficiency .", + "entities": [] + }, + { + "id": "9294", + "type": "gene", + "text": "The junctions between viral and cellular sequences were determined by DNA sequence analysis to be 517 nucleotides into the p30 sequence and 1 , 920 nucleotides into the polymerase sequence .", + "entities": [ + "p30 sequence" + ] + }, + { + "id": "9295", + "type": "gene", + "text": "The cause of death is often quite apparent from the pathological and toxicological findings ; however , the manner of death often gives the examining official some difficulty .", + "entities": [] + }, + { + "id": "9296", + "type": "gene", + "text": "There was a significant effect of hematocrit on the General Health scale on the SF - 36 ( P = 0 . 03 ) .", + "entities": [] + }, + { + "id": "9297", + "type": "gene", + "text": "Multiple single - stranded cis elements are associated with activated chromatin of the human c - myc gene in vivo .", + "entities": [ + "human c - myc gene" + ] + }, + { + "id": "9298", + "type": "gene", + "text": "Radiation therapy was effective in controlling symptomatic metastasis in all three patients .", + "entities": [] + }, + { + "id": "9299", + "type": "gene", + "text": "Evidence for the promoting role of the intra - uterine kinin release in the development of late hypertonic saline - induced abortion .", + "entities": [ + "intra - uterine kinin" + ] + }, + { + "id": "9300", + "type": "gene", + "text": "The 13 , 14 - dihydro - 15 - keto - metabolites of PGE2 and PGF2 alpha had no statistically significant antiarrhythmic effect .", + "entities": [] + }, + { + "id": "9301", + "type": "gene", + "text": "Twenty - one ELISA - positive sera were tested and confirmed positive by plaque reduction neutralization testing .", + "entities": [] + }, + { + "id": "9302", + "type": "gene", + "text": "Coronary arteries - - old and new .", + "entities": [] + }, + { + "id": "9303", + "type": "gene", + "text": "In this study , we tested this notion by using ligation - mediated PCR to assess the formation of recombination - activating gene ( RAG ) - dependent double - strand breaks ( DSBs ) at RSSs 3 ' of Ddelta3 and 5 ' of Jdelta1 .", + "entities": [ + "recombination - activating gene", + "RAG", + "Ddelta3", + "Jdelta1" + ] + }, + { + "id": "9304", + "type": "gene", + "text": "Bone marrow transplantation - 1979 .", + "entities": [] + }, + { + "id": "9305", + "type": "gene", + "text": "A cAMP - responsive element - like ( CRE - like , TGACGTGA ) promoter sequence and a protein kinase A signaling pathway are involved in this induction , and activation of both CRE binding protein ( CREB ) and activating transcription factor - 2 ( ATF - 2 ) is required in the above process .", + "entities": [ + "protein kinase A", + "CRE binding protein", + "CREB", + "activating transcription factor - 2", + "ATF - 2" + ] + }, + { + "id": "9306", + "type": "gene", + "text": "These results confirmed that cleavage of the leader peptide is the last step in nisin maturation and is necessary to generate a biologically active peptide .", + "entities": [ + "nisin" + ] + }, + { + "id": "9307", + "type": "gene", + "text": "After tilting , systolic blood pressure fell an average of 17 % in patients who cramped infrequently ( p = 0 . 0031 ) but only 10 % in frequently cramping patients .", + "entities": [] + }, + { + "id": "9308", + "type": "gene", + "text": "Primers for subsequent rounds of RACE were designed from the 5 ' - ends of amplified RACE products .", + "entities": [] + }, + { + "id": "9309", + "type": "gene", + "text": "The RET / PTC3 rearrangement is formed by fusion of the ELE1 and RET genes , and is highly prevalent in radiation - induced post - Chernobyl papillary thyroid carcinomas .", + "entities": [ + "RET", + "PTC3", + "ELE1", + "RET genes" + ] + }, + { + "id": "9310", + "type": "gene", + "text": "The C5 alpha - chain was encoded by 49 kilobases containing 26 exons ; the beta - chain was encoded by 29 kilobases containing 16 exons .", + "entities": [ + "C5 alpha - chain" + ] + }, + { + "id": "9311", + "type": "gene", + "text": "Detection of hemophilia A carriers .", + "entities": [] + }, + { + "id": "9312", + "type": "gene", + "text": "The intranodal mesothelial cells occupied the sinusoids of the lymph nodes and were initially suspected of being metastatic from the ovarian tumor in each case .", + "entities": [] + }, + { + "id": "9313", + "type": "gene", + "text": "In comparison with the 16 introns reported in AHA3 , AHA2 is missing one intron in the 5 ' - untranslated region and a second intron in the C - terminal coding region .", + "entities": [ + "AHA3", + "AHA2" + ] + }, + { + "id": "9314", + "type": "gene", + "text": "Functional studies which introduced a mutation in the AP2 core binding region as well as cotransfection experiments using an AP2 expression vector revealed that AP2 exerts a repressive role on the HGF gene promoter activity .", + "entities": [ + "AP2 core binding region", + "AP2", + "AP2", + "HGF gene promoter" + ] + }, + { + "id": "9315", + "type": "gene", + "text": "The mechanistic implications of aromatic non - responsiveness of autonomously expressed A - domain , despite its demonstrated ability to bind phenol , are discussed .", + "entities": [] + }, + { + "id": "9316", + "type": "gene", + "text": "Sprague - Dawley newborn rats ( n = 85 ) breathed 100 % oxygen ( O2 ) or room air ( RA ) during the first 8 days of life , and then RA .", + "entities": [] + }, + { + "id": "9317", + "type": "gene", + "text": "These results suggest that ULK2 is involved in a previously uncharacterized signaling pathway in mammalian cells .", + "entities": [ + "ULK2" + ] + }, + { + "id": "9318", + "type": "gene", + "text": "I .", + "entities": [] + }, + { + "id": "9319", + "type": "gene", + "text": "The LMW FGF - 2 up - regulated the PKC epsilon levels by 1 . 6 - fold ; by contrast the HMW isoform down - regulated the level of this PKC isotype by about 3 - fold and increased the amount of PKC delta by 1 . 7 - fold .", + "entities": [ + "LMW FGF - 2", + "PKC epsilon", + "HMW isoform", + "PKC isotype", + "PKC delta" + ] + }, + { + "id": "9320", + "type": "gene", + "text": "Mitomycin - C can cause severe necrosis and ulceration when extravasated inadvertently into skin and soft tissues following IV drug administration .", + "entities": [] + }, + { + "id": "9321", + "type": "gene", + "text": "HTLV - 1 decreases Th2 type of immune response in patients with strongyloidiasis .", + "entities": [] + }, + { + "id": "9322", + "type": "gene", + "text": "Spontaneous recovery occurs within 30 min to 2 hrs .", + "entities": [] + }, + { + "id": "9323", + "type": "gene", + "text": "We have generated a computer model of the C - terminal domain of the 434 repressor based on the crystal structure of the homologous UmuD ' protein .", + "entities": [ + "homologous UmuD ' protein" + ] + }, + { + "id": "9324", + "type": "gene", + "text": "This indicates that lipid peroxidation may be involved in the development of senile cataract and , as a direct consequence of retinal damage , also in the pathogenesis of cataract in diabetes and in severe myopia .", + "entities": [] + }, + { + "id": "9325", + "type": "gene", + "text": "We performed dipole estimation of spikes and SEP components in identical patients .", + "entities": [] + }, + { + "id": "9326", + "type": "gene", + "text": "Senior systems - - 45 ; Mental health and illness in old age - - 3 .", + "entities": [] + }, + { + "id": "9327", + "type": "gene", + "text": "e .", + "entities": [] + }, + { + "id": "9328", + "type": "gene", + "text": "Thus RV O2 demand fell when RC O2 supply was reduced , although a flow reserve was available .", + "entities": [] + }, + { + "id": "9329", + "type": "gene", + "text": "NDRF / NeuroD2 was co - precipitated with PKN from the lysate of COS - 7 cells transfected with both expression constructs for NDRF / NeuroD2 and PKN .", + "entities": [ + "NDRF", + "NeuroD2", + "PKN", + "NDRF", + "NeuroD2", + "PKN" + ] + }, + { + "id": "9330", + "type": "gene", + "text": "Our data suggest that trans - activation from the prothymosin intron enhancer is a faithful reflection of the transforming properties of the Myc protein .", + "entities": [ + "prothymosin intron enhancer", + "Myc protein" + ] + }, + { + "id": "9331", + "type": "gene", + "text": "Protein tyrosine phosphatases ( PTPs ) , together with protein tyrosine kinases ( PTKs ) , are involved in the regulation of cell activation , growth , and differentiation .", + "entities": [ + "Protein tyrosine phosphatases", + "PTPs", + "protein tyrosine kinases", + "PTKs" + ] + }, + { + "id": "9332", + "type": "gene", + "text": "This interaction inhibits the histone acetyltransferase activity of p300 , resulting in drastic reduction of nucleosomal histone acetylation and alteration of chromatin structure .", + "entities": [ + "histone acetyltransferase", + "p300", + "histone" + ] + }, + { + "id": "9333", + "type": "gene", + "text": "As a complement to genome - wide mapping and sequencing efforts , it is often important to generate detailed maps and sequence data for specific regions of interest .", + "entities": [] + }, + { + "id": "9334", + "type": "gene", + "text": "Most , however , would tell the spouse the full truth about both diagnosis and prognosis .", + "entities": [] + }, + { + "id": "9335", + "type": "gene", + "text": "Central venous catheter used for recording intracardiac electrocardiogram .", + "entities": [] + }, + { + "id": "9336", + "type": "gene", + "text": "Animals received a dose of dexamethasone ( 10 mg / kg i . p . ) prior to the protein - free surfactant preparation Exosurf ( pure phospholipids containing surfactant , Wellcome GmbH , Burgwedel , Germany ) and a rSP - C based surfactant , respectively .", + "entities": [] + }, + { + "id": "9337", + "type": "gene", + "text": "Although a wide range of cognitive functions had been tested , all but one seizure occurred during assessment of memory performance .", + "entities": [] + }, + { + "id": "9338", + "type": "gene", + "text": "In conclusion , marmoset monkey LHR seems to lack the sequence corresponding to exon 10 of the LHR gene in other mammalian species .", + "entities": [ + "marmoset monkey LHR", + "LHR gene" + ] + }, + { + "id": "9339", + "type": "gene", + "text": "Methyllevamisole was used as the internal standard .", + "entities": [] + }, + { + "id": "9340", + "type": "gene", + "text": "Raman investigation of YBa2 - xLaxCu3O7 ceramics .", + "entities": [] + }, + { + "id": "9341", + "type": "gene", + "text": "Our study was designed to investigate the effect of MMF on in vivo bone mineral metabolism .", + "entities": [] + }, + { + "id": "9342", + "type": "gene", + "text": "PURPOSE : To evaluate the kinetics of erythropoietin ( EPO ) production and address the pathogenesis of anemia of prematurity , we measured EPO levels in infants during the first year of life .", + "entities": [ + "erythropoietin", + "EPO", + "EPO" + ] + }, + { + "id": "9343", + "type": "gene", + "text": "Strains bearing the drs2 mutation process the 20S precursor of the mature 18S rRNA slowly and are deficient in 40S ribosomal subunits .", + "entities": [ + "drs2 mutation", + "20S precursor", + "mature 18S rRNA", + "40S ribosomal subunits" + ] + }, + { + "id": "9344", + "type": "gene", + "text": "The TB incidence in the \" AIRIN \" area , where about 20 % TB patients are homeless , shows highest rate of above 1 , 000 / 100 , 000 .", + "entities": [] + }, + { + "id": "9345", + "type": "gene", + "text": "The influence of patient - related factors on inter - observer variability in the evaluation of neurological signs was investigated .", + "entities": [] + }, + { + "id": "9346", + "type": "gene", + "text": "Anesthesia with M / K was reversed after 41 . 6 min of immobilization with atipamezole .", + "entities": [] + }, + { + "id": "9347", + "type": "gene", + "text": "Involvement of AP1 and PEA3 binding sites in the regulation of murine tissue inhibitor of metalloproteinases - 1 ( TIMP - 1 ) transcription .", + "entities": [ + "AP1", + "PEA3 binding sites", + "murine tissue inhibitor of metalloproteinases - 1", + "TIMP - 1" + ] + }, + { + "id": "9348", + "type": "gene", + "text": "We show that the surfaces of tracheal cartilage matrix are collagen - rich and surround a proteoglycan - rich core .", + "entities": [ + "collagen" + ] + }, + { + "id": "9349", + "type": "gene", + "text": "The hsp70 gene family of Neurospora crassa : cloning , sequence analysis , expression , and genetic mapping of the major stress - inducible member .", + "entities": [ + "hsp70 gene family" + ] + }, + { + "id": "9350", + "type": "gene", + "text": "The relations among various negative emotional and behavioral characteristics ( e . g . , aggression , anxiety , undercompliance , depressive mood ) and adjustment were examined through use of data from the 31 - year - old New York Longitudinal Study .", + "entities": [] + }, + { + "id": "9351", + "type": "gene", + "text": "There are regions with long runs of up to 45 % C or 35 % G residues .", + "entities": [] + }, + { + "id": "9352", + "type": "gene", + "text": "The amplification was achieved using two primers which correspond to TRH progenitor sequence ( Lys / Arg - Arg - Gln - His - Pro - Gly - Lys / Arg - Arg ) .", + "entities": [ + "TRH progenitor sequence" + ] + }, + { + "id": "9353", + "type": "gene", + "text": "In a prospective , multicentre trial the efficacy of an Vitex agnus castus L extract Ze 440 was investigated in 50 patients with pre - menstrual syndrome ( PMS ) .", + "entities": [] + }, + { + "id": "9354", + "type": "gene", + "text": "Evaluation of antiepileptic drug effect on membrane fluidity .", + "entities": [] + }, + { + "id": "9355", + "type": "gene", + "text": "METHODS - - 16 volunteered for spirometry with methacholine provocation test including a test for small airways function by volume of trapped gas ( VTG ) .", + "entities": [] + }, + { + "id": "9356", + "type": "gene", + "text": "In contrast , when the isoform containing the C epsilon4 domain joined directly to the M2 exon ( IgE grande ) is expressed in the J558L cell line , it is degraded intracellularly , suggesting a cell line - dependent regulation of secretion .", + "entities": [ + "IgE grande" + ] + }, + { + "id": "9357", + "type": "gene", + "text": "The authors found that except for fear and pugnacity all husband - wife trait correlations were positive , in contrast to Winch ' s principle of type I complementarity .", + "entities": [] + }, + { + "id": "9358", + "type": "gene", + "text": "A positive correlation between serum myoglobin and CA III concentrations ( rs = 0 . 933 , P < 0 . 001 ) was observed in hemodialyzed patients with chronic renal failure .", + "entities": [ + "serum myoglobin", + "CA III" + ] + }, + { + "id": "9359", + "type": "gene", + "text": "Behavioral and electrographic expression of natural sleep and wakefulness in reptiles", + "entities": [] + }, + { + "id": "9360", + "type": "gene", + "text": "The RAD6 / UBC2 gene from Saccharomyces cerevisiae encodes a ubiquitin - conjugating enzyme involved in DNA repair , induced mutagenesis , and sporulation .", + "entities": [ + "RAD6", + "UBC2", + "ubiquitin - conjugating enzyme" + ] + }, + { + "id": "9361", + "type": "gene", + "text": "Two new flavone glucosides , nevadensin 5 - O - beta - D - glucoside and nevadensin 5 - O - beta - D - glucosyl ( 1 - - > 6 ) beta - D - glucoside , have been isolated from the aerial parts of Lysionotus pauciflorus .", + "entities": [] + }, + { + "id": "9362", + "type": "gene", + "text": "Role of g2 in relating the Schwinger and Gerasimov - Drell - Hearn sum rules .", + "entities": [] + }, + { + "id": "9363", + "type": "gene", + "text": "Increased blood pressure during CyA treatment was independent of circulating ET - 1 levels .", + "entities": [ + "ET - 1" + ] + }, + { + "id": "9364", + "type": "gene", + "text": "There are no introns within the gene , which contains a 9360 - bp open reading frame and encodes a 377 - kDa protein .", + "entities": [] + }, + { + "id": "9365", + "type": "gene", + "text": "All four of the genes have a similar structure , with the receptor protein encoded in a single exon .", + "entities": [] + }, + { + "id": "9366", + "type": "gene", + "text": "A decamer sequence , 5 ' - CGA - CCCCUCC - 3 ' , complementary to a conserved sequence adjacent to the enzymatic cleavage site on the mitochondrial RNA substrate , is present in the RNAase MRP RNA .", + "entities": [ + "RNAase MRP RNA" + ] + }, + { + "id": "9367", + "type": "gene", + "text": "Malaria , anaemia , and HIV - 1 transmission in central Africa .", + "entities": [] + }, + { + "id": "9368", + "type": "gene", + "text": "A single rectal dose of 25 mg / kg will obtain this lower concentration within 1 h of administration and maintain it for up to 6 h .", + "entities": [] + }, + { + "id": "9369", + "type": "gene", + "text": "No relevant changes in heart rate , body weight , and plasma levels of renin activity and aldosterone concentration were observed .", + "entities": [ + "renin" + ] + }, + { + "id": "9370", + "type": "gene", + "text": "Immediate - early transcription from the channel catfish virus genome : characterization of two immediate - early transcripts .", + "entities": [ + "immediate - early transcripts" + ] + }, + { + "id": "9371", + "type": "gene", + "text": "The maps of Case 2 showed that a maximum first appeared on the upper right back and then moved down the right side of the posterior thorax .", + "entities": [] + }, + { + "id": "9372", + "type": "gene", + "text": "The ' Newcastle ' model , which is based on Hotelling ' s T2 statistic , proved to be more sensitive and diagnosed a systematic displacement for three prostate patients .", + "entities": [] + }, + { + "id": "9373", + "type": "gene", + "text": "Phase II study of paclitaxel and oral etoposide in patients with locally advanced or metastatic non - small cell lung cancer .", + "entities": [] + }, + { + "id": "9374", + "type": "gene", + "text": "Assessment of nutrient media in the diagnosis of diptheria", + "entities": [] + }, + { + "id": "9375", + "type": "gene", + "text": "Compared to its counterpart in the GPB gene , exon 3 of the GPE gene contains several point mutations , an insertion of 24 bp , and a stop codon which shortens the reading frame .", + "entities": [ + "GPB gene", + "GPE gene" + ] + }, + { + "id": "9376", + "type": "gene", + "text": "With a cutoff level for TSST - 1 of less than 100 pg / ml , 28 samples obtained from 12 patients were positive for TSST - 1 .", + "entities": [ + "TSST - 1", + "TSST - 1" + ] + }, + { + "id": "9377", + "type": "gene", + "text": "Both groups rejected pops with added SOA , decreasing mouthing times as SOA concentration increased .", + "entities": [] + }, + { + "id": "9378", + "type": "gene", + "text": "A three - phased analysis of treatment plans for 45 patients was undertaken .", + "entities": [] + }, + { + "id": "9379", + "type": "gene", + "text": "( iii ) In these cells , PKCbeta plays a unique Ras - independent role in mediating insulin but not EGF or other growth factor mitogenic signals .", + "entities": [ + "PKCbeta", + "Ras", + "insulin", + "EGF" + ] + }, + { + "id": "9380", + "type": "gene", + "text": "Thyroid lymphoma and its management .", + "entities": [] + }, + { + "id": "9381", + "type": "gene", + "text": "There were no significant changes in either the fatty acid composition of biliary lecithin or in the bile acid composition of bile .", + "entities": [] + }, + { + "id": "9382", + "type": "gene", + "text": "Uroflowmetry can detect dysuria , which may be poorly perceived or even unknown to the subjects themselves .", + "entities": [] + }, + { + "id": "9383", + "type": "gene", + "text": "Antituberculosis agents .", + "entities": [] + }, + { + "id": "9384", + "type": "gene", + "text": "Enzyme - linked immunosorbent assay for screening aflatoxin B1 in cottonseed products and mixed feed : collaborative study .", + "entities": [] + }, + { + "id": "9385", + "type": "gene", + "text": "It is now well established that progression through the eukaryotic cell cycle is controlled by oscillations in the activity of cyclin - dependent kinases ( CDKs ) .", + "entities": [ + "cyclin - dependent kinases", + "CDKs" + ] + }, + { + "id": "9386", + "type": "gene", + "text": "The RanQ69L preincubation leads to accumulation of CRM1 at the cytoplasmic periphery of the nuclear pore complex ( NPC ) in association with the p62 complex and Can / Nup214 .", + "entities": [ + "RanQ69L", + "CRM1", + "p62 complex", + "Can", + "Nup214" + ] + }, + { + "id": "9387", + "type": "gene", + "text": "MEK itself is activated via serine phosphorylation by upstream activator kinases , including c - raf , mos and MEK kinase .", + "entities": [ + "MEK", + "upstream activator kinases", + "c - raf", + "mos", + "MEK kinase" + ] + }, + { + "id": "9388", + "type": "gene", + "text": "In summary , Ca ( 2 + ) - dependent activation of NO production mediates apoptosis after TG exposure in JT / Neo cells .", + "entities": [ + "TG" + ] + }, + { + "id": "9389", + "type": "gene", + "text": "Sustained ventricular tachycardia and its successful prophylaxis during high - dose bolus interleukin - 2 therapy for metastatic renal cell carcinoma .", + "entities": [ + "interleukin - 2" + ] + }, + { + "id": "9390", + "type": "gene", + "text": "On the basis of these relations , a risk factor - selection scale ( RFSS ) ( range , 0 to 10 ) was developed by computing appropriate weights for each risk factor .", + "entities": [] + }, + { + "id": "9391", + "type": "gene", + "text": "Effects of a new antihypertensive agent , SGB - 1534 , on rat platelet aggregation .", + "entities": [] + }, + { + "id": "9392", + "type": "gene", + "text": "Dopamine receptor blockade and the neuroleptics , a crystallographic study .", + "entities": [ + "Dopamine receptor" + ] + }, + { + "id": "9393", + "type": "gene", + "text": "The expression of this clone in a wee1 / mik1 - deficient mutant causes an elongated cell phenotype under non - permissive growth conditions .", + "entities": [ + "wee1", + "mik1" + ] + }, + { + "id": "9394", + "type": "gene", + "text": "The structural gene encoding the novel lantibiotic epilancin K7 from Staphylococcus epidermidis K7 was cloned and its nucleotide sequence was determined .", + "entities": [ + "epilancin K7" + ] + }, + { + "id": "9395", + "type": "gene", + "text": "Diet and atopic eczema .", + "entities": [] + }, + { + "id": "9396", + "type": "gene", + "text": "Induced expression of Rnd3 is associated with transformation of polarized epithelial cells by the Raf - MEK - extracellular signal - regulated kinase pathway .", + "entities": [ + "Rnd3", + "Raf", + "MEK" + ] + }, + { + "id": "9397", + "type": "gene", + "text": "Mg2 + and Mn2 + compete for binding sites , with the former having lower affinity .", + "entities": [] + }, + { + "id": "9398", + "type": "gene", + "text": "Here we demonstrate that the mechanism of activation of HIF - 1alpha is a multi - step process which includes hypoxia - dependent nuclear import and activation ( derepression ) of the transactivation domain , resulting in recruitment of the CREB - binding protein ( CBP ) / p300 coactivator .", + "entities": [ + "HIF - 1alpha", + "CREB - binding protein", + "CBP", + "p300 coactivator" + ] + }, + { + "id": "9399", + "type": "gene", + "text": "The T - box motif is present in a family of genes whose structural features and expression patterns support their involvement in developmental gene regulation .", + "entities": [] + }, + { + "id": "9400", + "type": "gene", + "text": "Cp is normally the main promoter for EBNA mRNA initiation , so it appears that EBNA3C contributes to a negative autoregulatory control loop .", + "entities": [ + "Cp", + "EBNA mRNA", + "EBNA3C" + ] + }, + { + "id": "9401", + "type": "gene", + "text": "Fibular dimelia with deficiency of the tibia .", + "entities": [] + }, + { + "id": "9402", + "type": "gene", + "text": "When the promoter region was linked with a heterologous reporter gene , we found that the promoter region is inducible by both interferons ( interferon - alpha and - gamma ) and interferon regulatory factor 1 .", + "entities": [ + "interferons", + "interferon - alpha and - gamma", + "interferon regulatory factor 1" + ] + }, + { + "id": "9403", + "type": "gene", + "text": "Today there is no doubt that elevated plasma cholesterol levels should be lowered first by dietary modification even in early childhood , beginning at the age of two years .", + "entities": [] + }, + { + "id": "9404", + "type": "gene", + "text": "Percent identities of the mouse PP2 to mouse Y1 , mouse Y4 / PP1 and human Y2 receptors are 53 , 42 , and 31 , respectively .", + "entities": [ + "mouse PP2", + "mouse Y1", + "Y4", + "PP1", + "human Y2 receptors" + ] + }, + { + "id": "9405", + "type": "gene", + "text": "To identify cis - acting elements that target c - myc mRNA for downregulation during myogenesis , we stably transfected C2C12 cells with mutant myc genes or chimeric genes in which various myc sequences were fused to the human beta - globin gene or to the bacterial chloramphenicol acetyltransferase ( CAT ) gene .", + "entities": [ + "c - myc mRNA", + "mutant myc genes", + "myc sequences", + "human beta - globin gene", + "bacterial chloramphenicol acetyltransferase", + "CAT" + ] + }, + { + "id": "9406", + "type": "gene", + "text": "A new hemagglutination test for the on - slide assay of rheumatoid factor", + "entities": [] + }, + { + "id": "9407", + "type": "gene", + "text": "Recent work in this laboratory has shown that the gene coding for acetate kinase ( ackA ) in Sinorhizobium meliloti is up - regulated in response to phosphate limitation .", + "entities": [ + "acetate kinase", + "ackA" + ] + }, + { + "id": "9408", + "type": "gene", + "text": "Quantitative computed tomography for measuring vertebral bone mineral content offers high sensitivity and reproducibility .", + "entities": [] + }, + { + "id": "9409", + "type": "gene", + "text": "Biol .", + "entities": [] + }, + { + "id": "9410", + "type": "gene", + "text": "Mutations of the AP - 1 site of the TIMP - 1 promoter that prevented formation of HMAP - 1 caused a 70 % loss of activity in transfected activated HSCs .", + "entities": [ + "AP - 1 site", + "TIMP - 1 promoter", + "HMAP - 1" + ] + }, + { + "id": "9411", + "type": "gene", + "text": "Mnt : Max complexes also efficiently suppress Myc - dependent activation from the same promoter .", + "entities": [ + "Mnt", + "Max", + "Myc" + ] + }, + { + "id": "9412", + "type": "gene", + "text": "Activation of the SH2 - containing protein tyrosine phosphatase , SH - PTP2 , by phosphotyrosine - containing peptides derived from insulin receptor substrate - 1 .", + "entities": [ + "SH2 - containing protein tyrosine phosphatase", + "SH - PTP2", + "insulin receptor substrate - 1" + ] + }, + { + "id": "9413", + "type": "gene", + "text": "Besides the characterization and discussion of the experimental setup used , the rate constants obtained are discussed and compared with estimated values .", + "entities": [] + }, + { + "id": "9414", + "type": "gene", + "text": "For patients with recurrent or metastatic disease , the data suggest that I - 131 MIBG scintigraphy is the examination of choice .", + "entities": [] + }, + { + "id": "9415", + "type": "gene", + "text": "CONCLUSIONS : We obtained normal EPO levels for mothers and newborns for our area , similarly to the previously described ones .", + "entities": [ + "EPO" + ] + }, + { + "id": "9416", + "type": "gene", + "text": "Evoked electromyographic response to indirect supramaximal stimulation at 1 Hz was monitored in ten adult goats under thiopentone - halothane anaesthesia .", + "entities": [] + }, + { + "id": "9417", + "type": "gene", + "text": "The yeast retrotransposon Ty5 preferentially integrates into regions of silent chromatin .", + "entities": [ + "retrotransposon Ty5" + ] + }, + { + "id": "9418", + "type": "gene", + "text": "During pentobarbital anesthesia , the basal VO2 was 5 . 26 ml / kg / min and was increased by epinephrine in a dose dependent manner at plasma concentrations between 3 . 9 ng / ml ( VO2 = 5 . 68 ml / kg / min ) and 36 . 5 ng / ml ( VO2 = 6 . 47 ml / kg / min ) .", + "entities": [] + }, + { + "id": "9419", + "type": "gene", + "text": "In conclusion , these observations demonstrated that stratification of acute MI patients by plasma ANF level is a useful non - invasive method for predicting prognosis and for identifying individuals at high risk of cardiac death .", + "entities": [ + "ANF" + ] + }, + { + "id": "9420", + "type": "gene", + "text": "The YccA protein was found to be degraded in an FtsH - dependent manner in vivo and in vitro , whereas the YccA11 mutant protein , lacking eight amino acid residues within the amino - terminal cytoplasmic domain , was refractory to the degradation .", + "entities": [ + "YccA protein", + "FtsH", + "YccA11 mutant protein" + ] + }, + { + "id": "9421", + "type": "gene", + "text": "LCBF in normal and hypoxic puppies was correlated with local cerebral glucose utilization ( LCGU ) obtained under the same experimental conditions ( Duffy et al , 1982 ) .", + "entities": [] + }, + { + "id": "9422", + "type": "gene", + "text": "To test the feasibility of using liposomes to deliver therapeutic agents to the lungs , the effect of liposome - encapsulated superoxide dismutase ( SOD ) or catalase on pulmonary oxygen toxicity was studied in rats .", + "entities": [ + "superoxide dismutase", + "SOD", + "catalase" + ] + }, + { + "id": "9423", + "type": "gene", + "text": "Foveating saccades , therefore , can be distinguished from other FEMs on the basis of speed .", + "entities": [] + }, + { + "id": "9424", + "type": "gene", + "text": "In eight groups of subjects operating various hand - held vibrating tools and aged from 30 to 59 years , the prevalence rates of vibration - induced white finger ( VWF ) and numbness , pain , or stiffness in the upper and lower extremities were investigated .", + "entities": [] + }, + { + "id": "9425", + "type": "gene", + "text": "Colorimetric method of determining glycerin in the blood", + "entities": [] + }, + { + "id": "9426", + "type": "gene", + "text": "Convulsive status epilepticus after infusion of cisplatin", + "entities": [] + }, + { + "id": "9427", + "type": "gene", + "text": "Functional effects following subacute administration .", + "entities": [] + }, + { + "id": "9428", + "type": "gene", + "text": "ORF M1 has striking homology to poxvirus serpins , while ORF M11 encodes a potential homolog of Bcl - 2 - like molecules encoded by other gammaherpesviruses ( gene 16 of HVS and KSHV and the BHRF1 gene of EBV ) .", + "entities": [ + "serpins", + "Bcl - 2 - like molecules", + "gene 16", + "BHRF1 gene" + ] + }, + { + "id": "9429", + "type": "gene", + "text": "These results suggest that gluconeogenic genes are derepressed upon binding of Cat8p , whose synthesis depends on the release of Cat4p ( Mig1p ) from the CAT8 promoter .", + "entities": [ + "Cat8p", + "Cat4p", + "Mig1p", + "CAT8 promoter" + ] + }, + { + "id": "9430", + "type": "gene", + "text": "Asthmatic patients showed greater responses of both parameters to adrenaline than controls indicating that long - term corticosteroid treatment enhances the acute responses of plasminogen activator and clotting factor VIII to adrenaline infusion .", + "entities": [ + "plasminogen activator", + "clotting factor VIII" + ] + }, + { + "id": "9431", + "type": "gene", + "text": "METHODS : A structured interview was undertaken at the time of initial consultation and at subsequent 1 - year intervals regarding type of BHS , frequency of spells , associated phenomenon , sequelae , family history , and age at termination of spells .", + "entities": [] + }, + { + "id": "9432", + "type": "gene", + "text": "Atherosclerosis", + "entities": [] + }, + { + "id": "9433", + "type": "gene", + "text": "Cholangiography was performed in all cases and classified by a scoring system specifically developed for pediatric patients .", + "entities": [] + }, + { + "id": "9434", + "type": "gene", + "text": "Patients with lesions affecting the PRC but sparing the PHC , and patients with lesions affecting both PRC and PHC , performed an oculomotor delayed response task with unpredictably varied memory delays of up to 30 s .", + "entities": [] + }, + { + "id": "9435", + "type": "gene", + "text": "The finding that the chimeric TdT : : Pol beta protein possessed significant template - dependent polymerase activity suggests that aa 1 - 60 of Pol beta are involved in template utilization during the polymerization reaction , as suggested by the previous finding that the 8 - kDa N - terminal domain of Pol beta possesses ssDNA - binding activity [ Kumar et al . , J .", + "entities": [ + "chimeric TdT", + "Pol beta protein", + "Pol beta", + "Pol beta" + ] + }, + { + "id": "9436", + "type": "gene", + "text": "Cyclic AMP - dependent protein kinase binding to A - kinase anchoring proteins in living cells by fluorescence resonance energy transfer of green fluorescent protein fusion proteins .", + "entities": [ + "Cyclic AMP - dependent protein kinase", + "A - kinase", + "green fluorescent protein" + ] + }, + { + "id": "9437", + "type": "gene", + "text": "The pharmacokinetics of each tetracycline in serum and dermal , suction blister fluid were determined after oral doses of 300 mg lymecycline or 100 mg doxycycline on the 3rd day .", + "entities": [] + }, + { + "id": "9438", + "type": "gene", + "text": "The following aspects were assessed : ( 1 ) The effect on the cardiovascular system in terms of brachial arterial pressure , pulse rate , and oxygen consumption ( VO2 ) during exercise in 5 health volunteers ; ( 2 ) emg activity of the tibialis anterior and gastrocnemius muscles during exercise in the same 5 volunteers ; and ( 3 ) postexercise ankle pressure changes in 10 subjects with angiographically proven occlusive arterial diseases of the lower extremities .", + "entities": [] + }, + { + "id": "9439", + "type": "gene", + "text": "The 52 - protein subunit of T4 DNA topoisomerase is homologous to the gyrA - protein of gyrase .", + "entities": [ + "T4 DNA topoisomerase", + "gyrA - protein", + "gyrase" + ] + }, + { + "id": "9440", + "type": "gene", + "text": "The patients are two healthy adult males .", + "entities": [] + }, + { + "id": "9441", + "type": "gene", + "text": "Pargyline , a monoamine oxidase inhibitor , reduces peak 3 transiently ( max .", + "entities": [ + "monoamine oxidase" + ] + }, + { + "id": "9442", + "type": "gene", + "text": "The timing of fla gene expression in the cell cycle is determined by specialized forms of RNA polymerase and the appearance and / or activation of regulatory proteins .", + "entities": [ + "fla gene", + "RNA polymerase" + ] + }, + { + "id": "9443", + "type": "gene", + "text": "Potscoital test", + "entities": [] + }, + { + "id": "9444", + "type": "gene", + "text": "Exposure of endothelium to pulsatile shear stresses that followed a tape recording of physiological flow waveforms ( electromagnetic flowmeter ) did not cause gross injury or denudation even when peak shear exceeded 1500 dyne / cm2 .", + "entities": [] + }, + { + "id": "9445", + "type": "gene", + "text": "Furthermore , interactions were identified between endogenous E - cadherin and the chimera containing the E - cadherin extracellular domain and the desmoglein 1 intracellular domain providing in vivo evidence for previously predicted lateral interactions of E - cadherin extracellular domains .", + "entities": [ + "endogenous E - cadherin", + "E - cadherin extracellular domain", + "desmoglein 1 intracellular domain", + "E - cadherin extracellular domains" + ] + }, + { + "id": "9446", + "type": "gene", + "text": "CONCLUSION : The study demonstrates that transvaginal ultrasonography has an efficiency of 88 % in differentiating endometriomas from other ovarian masses with a specificity of 90 % .", + "entities": [] + }, + { + "id": "9447", + "type": "gene", + "text": "4 ) PU and PD lacked the canonical TATA or CAAT motifs , and are AT - rich .", + "entities": [ + "PU", + "PD" + ] + }, + { + "id": "9448", + "type": "gene", + "text": "A total of 57 patients with Hodgkin ' s disease limited to above the diaphragm ( Stages I and II , A and B ) were treated with radiation therapy alone at the University of Florida between 1964 and 1974 .", + "entities": [] + }, + { + "id": "9449", + "type": "gene", + "text": "Multistage models and the A - bomb survivor data : implications for carcinogenic mechanisms ?", + "entities": [] + }, + { + "id": "9450", + "type": "gene", + "text": "Here we report the cloning and characterization of Xenopus Pax - 5 and Pax - 8 , two orthologues of the Pax - 2 / 5 / 8 gene family .", + "entities": [ + "Xenopus Pax - 5", + "Pax - 8", + "Pax - 2 / 5 / 8 gene family" + ] + }, + { + "id": "9451", + "type": "gene", + "text": "Alternating proline / alanine sequence of beta B1 subunit originates from a repetitive DNA sequence .", + "entities": [ + "beta B1 subunit" + ] + }, + { + "id": "9452", + "type": "gene", + "text": "In gel mobility shift assays , we found no evidence for VDR - TR heterodimer interaction with any tested element .", + "entities": [ + "VDR", + "TR" + ] + }, + { + "id": "9453", + "type": "gene", + "text": "In vitro precipitation with a glutathione - S - transferase - fusion protein containing the C - terminal transactivation domain of STAT5a showed GH - regulated association of ERK1 / 2 with the fusion protein , while this was not seen when serine 780 in STAT5a was changed to alanine .", + "entities": [ + "glutathione - S - transferase - fusion protein", + "STAT5a", + "GH", + "ERK1 / 2", + "STAT5a" + ] + }, + { + "id": "9454", + "type": "gene", + "text": "In ferrets naturally infected with H . mustelae , a single dose ( 50 mg / kg , per os ) of fluorofamide completely inhibited bacterial urease .", + "entities": [ + "bacterial urease" + ] + }, + { + "id": "9455", + "type": "gene", + "text": "A reassessment of the prevalence data was carried out in the southern province of Uusimaa and in the western province of Vaasa , the prevalence day being January 1 , 1979 .", + "entities": [] + }, + { + "id": "9456", + "type": "gene", + "text": "Elementary visual hallucinations in migraine and epilepsy .", + "entities": [] + }, + { + "id": "9457", + "type": "gene", + "text": "We have previously mapped the defect in RIIIS / J to distal mouse Chr 11 , distinct from the Vwf locus on Chr 6 .", + "entities": [ + "Vwf locus" + ] + }, + { + "id": "9458", + "type": "gene", + "text": "CONCLUSION : We were unable to identify features of disease likely to be associated with a clinically useful response to inhaled NO therapy using the parameters studied .", + "entities": [] + }, + { + "id": "9459", + "type": "gene", + "text": "In group I , Paw , delta V , PaO2 , Vinj and VT significantly decreased whereas operating pressure and E significantly increased when the internal diameter of the injector cannula was reduced .", + "entities": [] + }, + { + "id": "9460", + "type": "gene", + "text": "Ig - alpha and Ig - beta contain extended cytoplasmic structure ( 61 and 48 amino acids , respectively ) and associate with cytoplasmic effectors indicating that they are directly involved in signal transduction .", + "entities": [ + "Ig - alpha", + "Ig - beta" + ] + }, + { + "id": "9461", + "type": "gene", + "text": "PATIENTS AND METHODS : In 807 consecutive patients from the Chilean National Registry of Acute Myocardial Infarction we analyzed the resolution of chest pain and ST segment elevation over 50 % within the first 90 min , abrupt CK rise within 8 h and T wave inversion in infarct related EKG leads within the first 24 h after thrombolysis .", + "entities": [ + "CK" + ] + }, + { + "id": "9462", + "type": "gene", + "text": "Since one group of adolescents more difficult to influence are those whose parents smoke , parental involvement in smoking prevention may be a powerful enhancer .", + "entities": [] + }, + { + "id": "9463", + "type": "gene", + "text": "All numbers refer to nucleotide positions on the wild - type HIV - 1 transcript .", + "entities": [] + }, + { + "id": "9464", + "type": "gene", + "text": "Overproduction , purification and characterization of M . HinfI methyltransferase and its deletion mutant .", + "entities": [ + "M . HinfI methyltransferase" + ] + }, + { + "id": "9465", + "type": "gene", + "text": "Overexpression of Sed5p allowed growth in the absence of Vti1p .", + "entities": [ + "Sed5p", + "Vti1p" + ] + }, + { + "id": "9466", + "type": "gene", + "text": "On physical examination a mild symmetrical polyarthritis of small and large joints was seen .", + "entities": [] + }, + { + "id": "9467", + "type": "gene", + "text": "A neuropsychological test battery was used that contained the Wisconsin card sorting test , Street completion test , Stroop test , a dichotic memory listening test , and a facial recognition test .", + "entities": [] + }, + { + "id": "9468", + "type": "gene", + "text": "However , the use of cyclosporin A is associated with an increased prevalence of hypertension in kidney transplant recipients .", + "entities": [] + }, + { + "id": "9469", + "type": "gene", + "text": "Synthetic enantiomers of drugs", + "entities": [] + }, + { + "id": "9470", + "type": "gene", + "text": "Successful treatment with nasal continuous positive airway pressure ( 8 . 3 + / - 1 . 5 cmH2O ) for 3 days caused a significant decrease in mean blood pressure in OSAS .", + "entities": [] + }, + { + "id": "9471", + "type": "gene", + "text": "This subfamily of genes all have a single ATP - binding domain at the N - terminus and a single C - terminal set of transmembrane segments .", + "entities": [] + }, + { + "id": "9472", + "type": "gene", + "text": "Within this sequence the MSAS gene was identified as a 5322 - bp - long open reading frame coding for a protein of 1774 amino acids and 190 , 731 Da molecular mass .", + "entities": [ + "MSAS gene" + ] + }, + { + "id": "9473", + "type": "gene", + "text": "A site - directed R618K mutation in the Stat5 SH2 domain abolished the phosphorylation by Jak2 , while deletion of the C terminus led to Stat5 hyperphosphorylation .", + "entities": [ + "SH2 domain", + "Jak2", + "Stat5" + ] + }, + { + "id": "9474", + "type": "gene", + "text": "Circulating oxytocin in male guinea pigs affected by the female cohabitation and reproductive condition .", + "entities": [ + "oxytocin" + ] + }, + { + "id": "9475", + "type": "gene", + "text": "Methanesulfonyl fluoride ( MSF ) : a double - blind , placebo - controlled study of safety and efficacy in the treatment of senile dementia of the Alzheimer type .", + "entities": [] + }, + { + "id": "9476", + "type": "gene", + "text": "Using the yeast two - hybrid system to screen for proteins which interact with Tax1 , we isolated the B subunit of the CCAAT binding protein NF - Y from a HeLa cDNA library .", + "entities": [ + "Tax1", + "NF - Y" + ] + }, + { + "id": "9477", + "type": "gene", + "text": "Data were processed with a semi - automatic computer program which develops an averaged - volume curve from an assigned LV region - of - interest .", + "entities": [] + }, + { + "id": "9478", + "type": "gene", + "text": "In infected mammalian cells , the ARV G and GNS genes are transcribed primarily as a polycistronic mRNA which appears to extend from the consensus sequence ( AACAG ) at the start of the G gene to the next recognized polyadenylation signal ( CATG [ A ] 7 ) located 697 nucleotides downstream of the GNS protein termination codon .", + "entities": [ + "ARV G", + "GNS genes", + "G gene", + "GNS protein" + ] + }, + { + "id": "9479", + "type": "gene", + "text": "Each group received 15 ml / kg of either 6 % pentafraction , 6 % pentastarch , or plasma followed two hours later by 1 . 5 micrograms / kg / 0 . 5 hr E .", + "entities": [] + }, + { + "id": "9480", + "type": "gene", + "text": "SRC - 1 can relieve the NF - kappaB - mediated repression of GR activity .", + "entities": [ + "SRC - 1", + "NF - kappaB", + "GR" + ] + }, + { + "id": "9481", + "type": "gene", + "text": "It is related to a variety of mammalian Golgi - associated proteins and to the yeast Uso1p , an essential protein involved in docking of endoplasmic reticulum - derived vesicles to the cis - Golgi .", + "entities": [ + "Uso1p" + ] + }, + { + "id": "9482", + "type": "gene", + "text": "Of 270 patients with well - defined drug reactions , 190 ( 70 per cent ) gave a positive response to the mast cell test .", + "entities": [] + }, + { + "id": "9483", + "type": "gene", + "text": "OBJECTIVE : The purpose of this article is to review balance instruments developed within the past 10 years that can be used in the clinic or home environment .", + "entities": [] + }, + { + "id": "9484", + "type": "gene", + "text": "In the icosahaedral MVMi capsid , this sequence forms the carboxy end of the amphipathic beta - strand I ( betaI ) , and all its basic residues are contiguously positioned at the face that in the unassembled subunit would be exposed to solvent .", + "entities": [] + }, + { + "id": "9485", + "type": "gene", + "text": "Instead , affective flattening was associated with both dopamine receptor sensitivity and psychomotor slowing .", + "entities": [ + "dopamine receptor" + ] + }, + { + "id": "9486", + "type": "gene", + "text": "Since considerable variations in length and primary sequence in the CDR3 ( complementarity determining region ) peptides of all the H - chains are evident , conservation of the D - region structure does not appear to be necessary for effective hapten binding .", + "entities": [ + "CDR3", + "complementarity determining region", + "H - chains", + "D - region" + ] + }, + { + "id": "9487", + "type": "gene", + "text": "Asthma was significantly more often associated with ASA group ( 91 % ) vs 46 % at AT and in only 16 % at INTR group .", + "entities": [] + }, + { + "id": "9488", + "type": "gene", + "text": "They also reported that E mu pim - 1 transgenic mice show greatly accelerated lymphoma development when infected with wild - type M - MuLV at birth .", + "entities": [ + "E mu pim - 1" + ] + }, + { + "id": "9489", + "type": "gene", + "text": "Adriamycin : comparison of a 5 - week schedule with a 3 - week schedule in the treatment of breast cancer .", + "entities": [] + }, + { + "id": "9490", + "type": "gene", + "text": "Human MN / CA9 gene , a novel member of the carbonic anhydrase family : structure and exon to protein domain relationships .", + "entities": [ + "Human MN / CA9 gene", + "carbonic anhydrase family" + ] + }, + { + "id": "9491", + "type": "gene", + "text": "99Tcm - DMP - HSA showed an almost identical behaviour to in vitro labelled red blood cells ( RBCs ) , which are generally considered the reference standard for blood pool agents .", + "entities": [] + }, + { + "id": "9492", + "type": "gene", + "text": "Halothane is metabolized by an oxidative pathway to stable , nonvolatile end products , trifluoroacetic acid ( TFAA ) and bromide ( Br - ) , and by reductive pathways to Br - and inorganic fluoride ( F - ) .", + "entities": [] + }, + { + "id": "9493", + "type": "gene", + "text": "In the case of the unspliceable intron , repression of luciferase expression likely involved two AUF1 - binding sequences , since luciferase expression was increased by deletion of these sites .", + "entities": [ + "luciferase", + "AUF1 - binding sequences", + "luciferase" + ] + }, + { + "id": "9494", + "type": "gene", + "text": "Surface spin waves in a Heisenberg ferrimagnet with a single - ion anisotropy ( uniaxial and nonuniaxial ) .", + "entities": [] + }, + { + "id": "9495", + "type": "gene", + "text": "Different doses of 15 - methyl - PGF2 alpha ( 0 . 125 - 10 mg ) were used to induce luteolysis and oestrus in 7 heifers with 28 treatments on day 8 - 12 of the oestrous cycle .", + "entities": [] + }, + { + "id": "9496", + "type": "gene", + "text": "The CDC7 gene has two in - frame AUG codons as possible translation start sites , which would produce 58 - and 56 - kDa proteins , respectively .", + "entities": [ + "CDC7 gene" + ] + }, + { + "id": "9497", + "type": "gene", + "text": "Six patients with glomerulonephritis in association with a ventriculovascular shunt were treated with three basic modes of therapy .", + "entities": [] + }, + { + "id": "9498", + "type": "gene", + "text": "Radiotherapy and early orchiectomy in stage D1 prostatic carcinoma", + "entities": [] + }, + { + "id": "9499", + "type": "gene", + "text": "In vitro assessment of the biocompatibility of dental materials - - the millipore filter method .", + "entities": [] + }, + { + "id": "9500", + "type": "gene", + "text": "These findings and the differential tissue distribution of p54 suggest that this novel SR protein may participate in regulation of alternative splicing in a tissue - and substrate - dependent manner .", + "entities": [ + "p54", + "SR protein" + ] + }, + { + "id": "9501", + "type": "gene", + "text": "Isolation and identification of genes activating UAS2 - dependent ADH2 expression in Saccharomyces cerevisiae .", + "entities": [ + "UAS2 - dependent ADH2" + ] + }, + { + "id": "9502", + "type": "gene", + "text": "When data were expressed in a cumulative manner , the response to intravenous adenosine 3 mg , 6 mg , 9 mg and 12 mg in the 24 episodes of PSVT were 5 episodes ( 21 % ) , 16 episodes ( 67 % ) , 20 episodes ( 83 % ) and 20 episodes ( 83 % ) respectively .", + "entities": [] + }, + { + "id": "9503", + "type": "gene", + "text": "SPA from PAG sites was associated with aversion .", + "entities": [] + }, + { + "id": "9504", + "type": "gene", + "text": "Molecular cloning of rat SH2 - containing inositol phosphatase 2 ( SHIP2 ) and its role in the regulation of insulin signaling .", + "entities": [ + "rat SH2 - containing inositol phosphatase 2", + "SHIP2", + "insulin" + ] + }, + { + "id": "9505", + "type": "gene", + "text": "2 cases of toxic lymphomononucleosis", + "entities": [] + }, + { + "id": "9506", + "type": "gene", + "text": "Incorporation of 0 . 1 or 0 . 2 M sodium dihydrogen phosphate in the sugar solutions resulted in a decrease in the shelf - life of diltiazem .", + "entities": [] + }, + { + "id": "9507", + "type": "gene", + "text": "This mechanism is not due to the observed grain boundary precipitates .", + "entities": [] + }, + { + "id": "9508", + "type": "gene", + "text": "Thus , Xlim - 1 not only contains a unique tyrosine - rich activation domain but also contains a negative regulatory domain in CT239 - 403 , suggesting a complex regulatory mechanism underlying the transcriptional activity of Xlim - 1 in the organizer .", + "entities": [ + "Xlim - 1", + "Xlim - 1" + ] + }, + { + "id": "9509", + "type": "gene", + "text": "In this paper , the current status of the understanding of the interaction mechanisms of ultrasound with biological media and the factors that govern different biological effects are surveyed .", + "entities": [] + }, + { + "id": "9510", + "type": "gene", + "text": "The recessive hos1 mutation causes enhanced induction of the CBF transcription factors by low temperature as well as of their downstream cold - responsive genes .", + "entities": [ + "hos1", + "CBF transcription factors" + ] + }, + { + "id": "9511", + "type": "gene", + "text": "Differentiation was not observed after cellular expression of GTPase - deficient forms of alpha i2 or alpha 0 , indicating selectivity for the Gq family of G proteins .", + "entities": [ + "GTPase", + "alpha i2", + "alpha 0", + "Gq family", + "G proteins" + ] + }, + { + "id": "9512", + "type": "gene", + "text": "The test for alpha - naphthyl esterase and quantitation of macrophages ( absolute number ) per infiltration area unit adjacent to the abscess suggest a direct correlation between the absolute number of macrophages and the width of the capsule .", + "entities": [ + "alpha - naphthyl esterase" + ] + }, + { + "id": "9513", + "type": "gene", + "text": "GAL4 - VP16 - mediated antirepression required an auxiliary factor , denoted as a co - antirepressor , which was partially purified from Drosophila embryos .", + "entities": [ + "GAL4", + "VP16" + ] + }, + { + "id": "9514", + "type": "gene", + "text": "Roizman , J .", + "entities": [] + }, + { + "id": "9515", + "type": "gene", + "text": "40 patients with chronic osteomyelitis were treated per os with the bactericidal beta - lactam - antibiotic cephalexin during 3 to 60 weeks .", + "entities": [] + }, + { + "id": "9516", + "type": "gene", + "text": "The CHARGE association is a collection of multisystem congenital anomalies including choanal atresia .", + "entities": [] + }, + { + "id": "9517", + "type": "gene", + "text": "A stratified random sample of 20 active employees from a cohort of phenoxy herbicide workers was selected in 1995 for determining PCDD and PCDF congeners in blood lipids to assess the extent of past PCDD and PCDF exposure in this cohort and whether that exposure might explain site - specific cancer findings in the total cohort .", + "entities": [] + }, + { + "id": "9518", + "type": "gene", + "text": "Biological action and kinetics of the elimination of tritium oxide in dogs", + "entities": [] + }, + { + "id": "9519", + "type": "gene", + "text": "The Ig - related , typical metazoan , module is classified to the disulphide lacking Ig members and represents the phylogenetic earliest member of this group .", + "entities": [ + "Ig", + "Ig members" + ] + }, + { + "id": "9520", + "type": "gene", + "text": "We demonstrate that both R and Z activate the cellular stress mitogen - activated protein ( MAP ) kinases , p38 and JNK , resulting in phosphorylation ( and activation ) of the cellular transcription factor ATF2 .", + "entities": [ + "R", + "Z", + "mitogen - activated protein ( MAP ) kinases", + "p38", + "JNK", + "cellular transcription factor ATF2" + ] + }, + { + "id": "9521", + "type": "gene", + "text": "The data suggest that like in yeast , in plants a certain subfamily of UBC is specifically involved in the proteolytic degradation of abnormal proteins as result of stress .", + "entities": [ + "UBC" + ] + }, + { + "id": "9522", + "type": "gene", + "text": "The human purH cDNA is 1776 base pairs in length encoding for a 591 - amino acid polypeptic ( Mr = 64 , 425 ) .", + "entities": [ + "human purH cDNA" + ] + }, + { + "id": "9523", + "type": "gene", + "text": "These findings suggest that fodrin proteolysis in vivo may reflect the activity of multiple ICE / Ced - 3 proteases whose partial sensitivity to DEVD - CHO reflects a limited contribution from CPP32 , or an ICE / Ced - 3 protease less sensitive than CPP32 to DEVD - CHO inhibition .", + "entities": [ + "fodrin", + "ICE", + "Ced - 3", + "CPP32", + "ICE", + "Ced - 3", + "CPP32" + ] + }, + { + "id": "9524", + "type": "gene", + "text": "Since GAGs are the components of cartilage matrix , the depletion of which is associated with osteoarthrosis , a method for measuring sulphated GAG synthesis in culture has been investigated .", + "entities": [] + }, + { + "id": "9525", + "type": "gene", + "text": "The clinical picture and laboratory parameters were consistent with a serum sickness reaction .", + "entities": [] + }, + { + "id": "9526", + "type": "gene", + "text": "This DNA motif represents a novel protein - binding sequence .", + "entities": [] + }, + { + "id": "9527", + "type": "gene", + "text": "Human synovial fluid : detection of a new component .", + "entities": [] + }, + { + "id": "9528", + "type": "gene", + "text": "Here , we alter the dimerization specificity of Fos by precisely replacing its leucine zipper with that from GCN4 .", + "entities": [ + "Fos", + "GCN4" + ] + }, + { + "id": "9529", + "type": "gene", + "text": "Drosophila UbcD1 encodes a highly conserved ubiquitin - conjugating enzyme involved in selective protein degradation .", + "entities": [ + "Drosophila UbcD1", + "ubiquitin" + ] + }, + { + "id": "9530", + "type": "gene", + "text": "To investigate the effects of isotretinoin on HDL , we measured HDL - C , HDL phospholipids ( HDL - PL ) , apoprotein A1 ( apo A - 1 ) , and HDL - C subfractions ( HDL2 - C and HDL3 - C ) in 24 healthy , male patients receiving a 16 - week course of isotretinoin ( 1 . 0 mg / kg / day ) for treatment of severe acne vulgaris .", + "entities": [ + "HDL", + "HDL - C", + "HDL", + "HDL - PL", + "apoprotein A1", + "apo A - 1", + "HDL - C", + "HDL2 - C", + "HDL3 - C" + ] + }, + { + "id": "9531", + "type": "gene", + "text": "The wavenumbers corresponding to the normal modes of vibration were calculated using the DFT ( B3LYP / 6 - 31G * * ) approximation and their agreement with the measured values improved after scaling of the associated force field .", + "entities": [] + }, + { + "id": "9532", + "type": "gene", + "text": "Subhuman primates appear to be more sensitive to reproductive and other adverse effects of PCBs than humans .", + "entities": [] + }, + { + "id": "9533", + "type": "gene", + "text": "In the absence of Mg2 + , a hydrophobic exonuclease site dominates over the polymerase site for possession of the primer terminus .", + "entities": [] + }, + { + "id": "9534", + "type": "gene", + "text": "It is shown that the displacement distribution measured by q - space MRI in both the large displacement ( i . e . , large r ) and the long - wavelength ( i . e . , small q ) limits is the same 3D Gaussian displacement distribution assumed in DT - MRI .", + "entities": [] + }, + { + "id": "9535", + "type": "gene", + "text": "When both lesions were complete lateral hemisections in weanling operates , little behavioral recovery was observed , similar to complete spinal cord transection ( N = 3 ) .", + "entities": [] + }, + { + "id": "9536", + "type": "gene", + "text": "The significance of these palindromic domains in this ORF is unclear but the coincidence of the end of one larger palindrome with the end of the translated protein sequence that has homology with the B chain of insulin suggests that the palindromes may divide the T2 protein into several functional units .", + "entities": [ + "insulin", + "T2 protein" + ] + }, + { + "id": "9537", + "type": "gene", + "text": "Picture the smell .", + "entities": [] + }, + { + "id": "9538", + "type": "gene", + "text": "Comparison of the proportion of nonsynonymous ( pN ) and synonymous ( pS ) substitutions occurring per site within tamarin variable region genes demonstrated a reduction in pN in the framework regions compared with pN in the presumed MHC contact regions ( CDR1 and CDR2 ) .", + "entities": [ + "tamarin variable region genes", + "MHC contact regions", + "CDR1", + "CDR2" + ] + }, + { + "id": "9539", + "type": "gene", + "text": "Absorption varied between 65 and 95 per cent , with a mean absorption of 80 per cent , in both pregnant and non - pregnant subjects .", + "entities": [] + }, + { + "id": "9540", + "type": "gene", + "text": "We have carried out a comprehensive and systematic mutagenesis of the Cse4p N terminus to analyze its function .", + "entities": [ + "Cse4p N terminus" + ] + }, + { + "id": "9541", + "type": "gene", + "text": "In 14 patients whose PaCO2 was greater than or equal to 39 torr ( range 39 to 58 torr ) and clinical asthma score was 6 or greater , PaCO2 decreased a mean of 11 . 7 torr during a mean of 8 . 1 hours .", + "entities": [] + }, + { + "id": "9542", + "type": "gene", + "text": "Several secondary structure elements were identified .", + "entities": [] + }, + { + "id": "9543", + "type": "gene", + "text": "The effects of loading the respiratory pumps on the oxygen consumption of Callionymus lyra .", + "entities": [] + }, + { + "id": "9544", + "type": "gene", + "text": "The mean thickness of the visceral peritoneum was comparable in both groups of animals , but , macroscopically , more severe fibrosis was found in the peritoneum of rats exposed to CAPD 3 as compared with animals treated with CAPD 3 Balance ( p < 0 . 05 ) .", + "entities": [] + }, + { + "id": "9545", + "type": "gene", + "text": "All 33 subjects were given psychometric instruments for measuring various components of anger and anxiety : Spielberger ' s State - Trait Personality Inventory , the Anger Expression Scale , and the State Anger Reaction Scale .", + "entities": [] + }, + { + "id": "9546", + "type": "gene", + "text": "However , at lower temperature the positive staircase was not clear and rather negative staircase appeared ( 1 - - 3 Hz ) .", + "entities": [] + }, + { + "id": "9547", + "type": "gene", + "text": "Detailed molecular organization of the coding and upstream regulatory regions of the murine homeodomain - containing gene , Msx - 1 , is reported .", + "entities": [ + "homeodomain - containing gene", + "Msx - 1" + ] + }, + { + "id": "9548", + "type": "gene", + "text": "Two overlapping clones contained the complete Adh - 2 gene composed of nine exons in a 12 - kb region , with the placement of introns matching that observed in other mammalian ADH genes .", + "entities": [ + "Adh - 2 gene", + "mammalian ADH genes" + ] + }, + { + "id": "9549", + "type": "gene", + "text": "Mutation of the presumptive phosphorylated tyrosine and threonine residues of Mpk1p individually to phenylalanine and alanine , respectively , severely impaired Mpk1p function .", + "entities": [ + "Mpk1p", + "Mpk1p" + ] + }, + { + "id": "9550", + "type": "gene", + "text": "Isolation and genomic structure of a human homolog of the yeast periodic tryptophan protein 2 ( PWP2 ) gene mapping to 21q22 . 3 .", + "entities": [ + "yeast periodic tryptophan protein 2", + "PWP2" + ] + }, + { + "id": "9551", + "type": "gene", + "text": "Oncological , clinical and psychological aspects are evaluated according to experience accumulated in recent years , with immediate and delayed reconstruction , carried out in the most diverse specialized centers .", + "entities": [] + }, + { + "id": "9552", + "type": "gene", + "text": "Treatment of Paget ' s disease .", + "entities": [] + }, + { + "id": "9553", + "type": "gene", + "text": "Plasma membranes of cultured cells contain high affinity receptors for high density lipoprotein ( HDL ) that appear to mediate removal of excess intracellular cholesterol .", + "entities": [ + "high density lipoprotein", + "HDL" + ] + }, + { + "id": "9554", + "type": "gene", + "text": "Hair and blood samples were taken before vitamin C or placebo supplementation was started and at monthly intervals thereafter for three months .", + "entities": [] + }, + { + "id": "9555", + "type": "gene", + "text": "Nine animals served as control animals , whereas 20 animals received a focal arachnoid scar at C1 - C2 , which was produced by placement of a kaolin - soaked fibrin sponge on the posterior surface of the spinal cord .", + "entities": [ + "fibrin" + ] + }, + { + "id": "9556", + "type": "gene", + "text": "These results show that the neonate differs from the adult in respect of both the nature of effects of the drug and sensitivity to it .", + "entities": [] + }, + { + "id": "9557", + "type": "gene", + "text": "Of the 53 units tested during sinusoidal motion at 0 . 05 Hz ( 9 . 1 cm / s ) , 1 ( 1 . 9 % ) was responsive to the otolith input only , 13 ( 24 . 5 % ) were influenced by the visual input only and 23 ( 43 . 4 % ) responded to both modalities .", + "entities": [] + }, + { + "id": "9558", + "type": "gene", + "text": "The nucleotide ( nt ) sequences of the exons , exon / intron boundaries and 5 ' - and 3 ' - untranslated regions were determined .", + "entities": [] + }, + { + "id": "9559", + "type": "gene", + "text": "Using GST - PKR fusion chromatography , direct physical interaction between the mouse and human PKR homologs was established .", + "entities": [ + "GST", + "PKR", + "human PKR homologs" + ] + }, + { + "id": "9560", + "type": "gene", + "text": "For an unsupervised program , the costs were estimated at $ 311 for the first year and $ 73 for all additional years .", + "entities": [] + }, + { + "id": "9561", + "type": "gene", + "text": "A case of manifest latent nystagmus of late onset in a 13 - year - old girl is reported .", + "entities": [] + }, + { + "id": "9562", + "type": "gene", + "text": "Normal alpha1 ( I ) collagen mRNA showed no significant reduction when AR or IR was expressed from the pHbetaAPr - 1 - neo vector and a small ( 10 - 20 % ) but significant reduction when either ribozyme was expressed from the pCI . neo vector .", + "entities": [ + "alpha1 ( I ) collagen mRNA" + ] + }, + { + "id": "9563", + "type": "gene", + "text": "Based on mutational data and possible mRNA structure , we hypothesized about the effect of mRNA structure on translation of the two major C / EBPepsilon isoforms : p32 and p30 .", + "entities": [ + "C / EBPepsilon isoforms", + "p32", + "p30" + ] + }, + { + "id": "9564", + "type": "gene", + "text": "Second , when the NBF1 + R protein , the NBF2 protein , and a mixture of the two proteins were folded separately and analyzed by molecular sieve chomatography , the mixture was found to elute prior to either NBF1 + R or NBF2 .", + "entities": [ + "NBF1 + R protein", + "NBF2 protein", + "NBF1 + R", + "NBF2" + ] + }, + { + "id": "9565", + "type": "gene", + "text": "Analysis of the sequence upstream of this initiation codon reveals the presence of a promotor sequence .", + "entities": [] + }, + { + "id": "9566", + "type": "gene", + "text": "Hemolytic jaundice due to G6PD deficiency causing kernicterus in a female newborn .", + "entities": [ + "G6PD" + ] + }, + { + "id": "9567", + "type": "gene", + "text": "A new bioencapsulation technology for microbial inoculants .", + "entities": [] + }, + { + "id": "9568", + "type": "gene", + "text": "The human cDNA clone NFBD1 ( previously designated KIAA0170 ) encodes a novel protein ( 2089 amino acids in length ; calculated molecular mass 226 , 440 D ) with possible BRCT domains at its carboxy terminus ( amino acid residues 1894 - 2089 ) .", + "entities": [ + "BRCT domains" + ] + }, + { + "id": "9569", + "type": "gene", + "text": "Moreover , a severe decrease of antithrombin activity became evident during both experiments ( eg , in experiment 2 from 95 . 6 + / - 4 . 8 to 59 . 2 + / - 6 . 6 % ) .", + "entities": [ + "antithrombin" + ] + }, + { + "id": "9570", + "type": "gene", + "text": "RNA in situ hybridization on brain sections of normal human embryos revealed a strong labeling in restricted areas of the cerebral cortex .", + "entities": [] + }, + { + "id": "9571", + "type": "gene", + "text": "Recently , a distantly related UmuC - homolog , DinB , has also been identified in E . coli .", + "entities": [ + "UmuC - homolog", + "DinB" + ] + }, + { + "id": "9572", + "type": "gene", + "text": "In this case the degree of promoter methylation , which could extend beyond the T - DNA borders , was not correlated with the reduction in steady - state poly ( A ) + mRNA levels , the silenced state was transmitted through meiosis and reactivation lasted several generations .", + "entities": [] + }, + { + "id": "9573", + "type": "gene", + "text": "Cystatin A , a cysteine proteinase inhibitor , is one of the precursor proteins of cornified cell envelope of keratinocytes and is expressed during the late stage of keratinocyte differentiation .", + "entities": [ + "Cystatin A", + "cysteine proteinase", + "cornified cell envelope" + ] + }, + { + "id": "9574", + "type": "gene", + "text": "The identification of viable myocardium with both 99mTc - tetrofosmin and 201Tl can be greatly enhanced to a similar degree if the severity of reduction in activity within nonreversible defects is considered .", + "entities": [] + }, + { + "id": "9575", + "type": "gene", + "text": "Structural features of the minimal DNA binding domain ( M98 - F219 ) of human nucleotide excision repair protein XPA .", + "entities": [ + "human nucleotide excision repair protein XPA" + ] + }, + { + "id": "9576", + "type": "gene", + "text": "Cleavage and DNA joining reactions , carried out by human immunodeficiency virus type 1 ( HIV - 1 ) integrase , are necessary to effect the covalent insertion of HIV - 1 DNA into the host genome .", + "entities": [ + "human immunodeficiency virus type 1 ( HIV - 1 ) integrase" + ] + }, + { + "id": "9577", + "type": "gene", + "text": "The murine Htf9 - a / RanBP1 and Htf9 - c genes are divergently transcribed from a shared TATA - less promoter .", + "entities": [ + "Htf9 - a", + "RanBP1", + "Htf9 - c genes" + ] + }, + { + "id": "9578", + "type": "gene", + "text": "Temporal relationships and the development phase affected .", + "entities": [] + }, + { + "id": "9579", + "type": "gene", + "text": "Selenium , as a constituent of glutathione peroxidase , plays a role in the antioxidant defense systems of the body , but other metabolic roles for selenium may yet be discovered .", + "entities": [ + "glutathione peroxidase" + ] + }, + { + "id": "9580", + "type": "gene", + "text": "Transfection of cDNAs for three mutant enzymes into FPGS - null Chinese hamster ovary cells restored a reduced level of clonal growth , whereas a T339I mutant supported growth at a level comparable to that of the wild - type enzyme .", + "entities": [ + "FPGS" + ] + }, + { + "id": "9581", + "type": "gene", + "text": "Lack of controlled prospective studies of sleep electroencephalograms ( EEG ) , and the use of medication , in children with developmental dysphasia , may deny appropriate treatment strategies to children with severe developmental speech and language disorders .", + "entities": [] + }, + { + "id": "9582", + "type": "gene", + "text": "Type I cysts ( with a high K + / Na + ratio ) tend to have higher total PSA than Type II cysts .", + "entities": [ + "PSA" + ] + }, + { + "id": "9583", + "type": "gene", + "text": "Just before inserting on the anterior margin and apex of the iliac crest it widens , assuming the aspect of a small cone .", + "entities": [] + }, + { + "id": "9584", + "type": "gene", + "text": "Histological changes , including cortical cell involution and hemorrhage occurring during the neonatal period , would seem to have crucial relevance to the remodeling of the adrenal vasculature .", + "entities": [] + }, + { + "id": "9585", + "type": "gene", + "text": "Localization of the insertion locus in the yeast genome and complementation studies with the temperature - sensitive mutant indicate that the two mutations are allelic .", + "entities": [] + }, + { + "id": "9586", + "type": "gene", + "text": "Gal4 - Eed fusion protein represses transcription of a reporter gene driven by a promoter that contains Gal4 - binding DNA elements .", + "entities": [ + "Gal4", + "Eed", + "Gal4 - binding DNA elements" + ] + }, + { + "id": "9587", + "type": "gene", + "text": "Subsequent to their secretion , the IGF - II in xz97 and G11 cells accumulated in the conditioned medium mostly as two partially processed species with appMr , of 17K and 14K , respectively .", + "entities": [ + "IGF - II" + ] + }, + { + "id": "9588", + "type": "gene", + "text": "Some of them produce gigantic sperm several times the total male body length .", + "entities": [] + }, + { + "id": "9589", + "type": "gene", + "text": "A single base change ( A8G ) in either sequence reduces hnRNP A2 binding and , in the case of A2RE - 2 , inhibits RNA transport .", + "entities": [ + "hnRNP A2", + "A2RE - 2" + ] + }, + { + "id": "9590", + "type": "gene", + "text": "Fisher ' s exact test or Pearson ' s chi2 test were used for statistical analysis .", + "entities": [] + }, + { + "id": "9591", + "type": "gene", + "text": "An intact neurovascular supply is essential for the viability of a muscle flap .", + "entities": [] + }, + { + "id": "9592", + "type": "gene", + "text": "Simian immunodeficiency virus ( SIV ) is a lentivirus with morphological and antigenic similarities to human immunodeficiency virus , the causative agent of acquired immunodeficiency syndrome ( AIDS ) of humans .", + "entities": [] + }, + { + "id": "9593", + "type": "gene", + "text": "Both fusion proteins form stable specific complexes with a short DNA duplex harboring the CTGT ( at ) 4ACAG consensus sequence of the LexA repressor .", + "entities": [ + "LexA repressor" + ] + }, + { + "id": "9594", + "type": "gene", + "text": "The specificity of action of C / EBP family members may be derived from the characteristics of each factor , including the expression profiles , the DNA binding affinities , the cofactors , and so on , in addition to the DNA binding specificities .", + "entities": [ + "C / EBP family members" + ] + }, + { + "id": "9595", + "type": "gene", + "text": "As is deduced from the nucleotide sequence of the cDNA , CBS - 1 contains an open reading frame consisting of 182 amino acids , with a molecular weight of 19 . 5kDa .", + "entities": [ + "CBS - 1" + ] + }, + { + "id": "9596", + "type": "gene", + "text": "These components both had a median R2 of 0 . 84 , compared to median R2s ranging from 0 . 37 to 0 . 83 for five commonly used ad hoc EEG components .", + "entities": [] + }, + { + "id": "9597", + "type": "gene", + "text": "The human SHBG proximal promoter was analyzed by DNase I footprinting , and the functional significance of 6 footprinted regions ( FP1 - FP6 ) within the proximal promoter was studied in human HepG2 hepatoblastoma cells .", + "entities": [ + "human SHBG proximal promoter", + "DNase I" + ] + }, + { + "id": "9598", + "type": "gene", + "text": "To characterize the expression of this DNA repair enzyme , we have isolated the corresponding genomic clone .", + "entities": [ + "DNA repair enzyme" + ] + }, + { + "id": "9599", + "type": "gene", + "text": "Biol .", + "entities": [] + }, + { + "id": "9600", + "type": "gene", + "text": "The high sequence homology , similar genomic structure , and identical chromosomal loci of hKID , MIP , and AQP - 2 suggest a MIP family gene cluster at chromosome locus 12q13 .", + "entities": [ + "hKID", + "MIP", + "AQP - 2", + "MIP family gene cluster" + ] + }, + { + "id": "9601", + "type": "gene", + "text": "Phylogenetic analysis showed that the ToLCV isolates from Bangalore constitute a group of viruses separated from those of Northern India .", + "entities": [] + }, + { + "id": "9602", + "type": "gene", + "text": "A segmental analysis of the key regions of HLA - DR1 that control T cell allorecognition was performed by using a series of transfected cell lines expressing the products of recombinant DRB / H - 2Eb genes , paired with either DR alpha or H - 2E alpha .", + "entities": [ + "HLA - DR1", + "DRB", + "H - 2Eb", + "DR alpha", + "H - 2E alpha" + ] + }, + { + "id": "9603", + "type": "gene", + "text": "Little or no protection was detected using adrenal cortex , adrenal medulla , liver , kidney cortex , spleen , or T - lymphocyte total RNA .", + "entities": [] + }, + { + "id": "9604", + "type": "gene", + "text": "Despite this there was no difference in the intubating conditions at one minute with 25 excellent / 5 good in the suxamethonium group and 27 excellent / 3 good in the rocuronium group .", + "entities": [] + }, + { + "id": "9605", + "type": "gene", + "text": "A rapid fluorimetric procedure for the determination of the fungicide 5 - fluorocytosine in serum is described .", + "entities": [] + }, + { + "id": "9606", + "type": "gene", + "text": "The presence of an additional sequence of nucleotides 145 - 165 from the 3 ' end of RNA3 enhanced template recognition by RdRp in vitro and accumulation of RNA3 in vivo to wild - type levels .", + "entities": [ + "RNA3", + "RdRp", + "RNA3" + ] + }, + { + "id": "9607", + "type": "gene", + "text": "The drug packets contained acetyl aspirin , acetaminophen and chloramphenicol .", + "entities": [] + }, + { + "id": "9608", + "type": "gene", + "text": "Surprisingly , the full - deletion mutant showed a strong block in virus release , suggesting that NC is involved in virus assembly .", + "entities": [ + "NC" + ] + }, + { + "id": "9609", + "type": "gene", + "text": "The authors report the results of a series of toxicological tests conducted on plastic materials ( polyethylene ) activated with tetraphenylbutadiene ( TPB ) an additive recently proposed as a sensitizer capable of photodegrading plastic materials .", + "entities": [] + }, + { + "id": "9610", + "type": "gene", + "text": "The interaction between U ( L ) 3 .", + "entities": [] + }, + { + "id": "9611", + "type": "gene", + "text": "Mutations in seven other lts genes do not result in the mak - phenotype .", + "entities": [ + "lts genes", + "mak - phenotype" + ] + }, + { + "id": "9612", + "type": "gene", + "text": "Expression of this protein in E . coli demonstrated that tyrosine was incorporated during suppression and that yeast cytoplasmic TyrRS activity was produced .", + "entities": [ + "yeast cytoplasmic TyrRS" + ] + }, + { + "id": "9613", + "type": "gene", + "text": "Of major concern to food processors is the inadvertent cross - contact of food products with allergenic residues , which could result in potentially life - threatening reactions in those with a food allergy .", + "entities": [] + }, + { + "id": "9614", + "type": "gene", + "text": "Mutations that alter photoreceptor cell structure and development were isolated that fail to complement these deletions .", + "entities": [] + }, + { + "id": "9615", + "type": "gene", + "text": "Additional information including echocardiographic sequences , perioperative video sequences , x - ray analysis , angiograms , etc .", + "entities": [] + }, + { + "id": "9616", + "type": "gene", + "text": "is represented in the program .", + "entities": [] + }, + { + "id": "9617", + "type": "gene", + "text": "In ten other experiments ( 5 experimental and 5 control rats ) 99mTc - sulfur colloid was injected intravenously .", + "entities": [] + }, + { + "id": "9618", + "type": "gene", + "text": "The method described may prove useful in studying the physiology of the nasal cycle .", + "entities": [] + }, + { + "id": "9619", + "type": "gene", + "text": "The yeast C - type cyclin Ume3p / Srb11p and its cyclin - dependent kinase ( Cdk ) Ume5p are required for the full repression of genes involved in the stress response or meiosis .", + "entities": [ + "Ume3p", + "Srb11p", + "cyclin - dependent kinase", + "Cdk", + "Ume5p" + ] + }, + { + "id": "9620", + "type": "gene", + "text": "A DNase I - hypersensitive site has also been mapped in the 258 - base pair enhancer region .", + "entities": [ + "DNase I - hypersensitive site" + ] + }, + { + "id": "9621", + "type": "gene", + "text": "The cloned HindIII fragment , which was shown by DNA sequence analysis to encode the N - terminal half of the B . subtilis IF2 protein and 0 . 2 kb of upstream flanking sequence , was utilized as a homologous probe to clone an overlapping 2 . 76 - kb ClaI chromosomal fragment containing the entire IF2 structural gene .", + "entities": [ + "HindIII fragment", + "B . subtilis IF2 protein", + "2 . 76 - kb ClaI chromosomal fragment", + "entire IF2 structural gene" + ] + }, + { + "id": "9622", + "type": "gene", + "text": "A 73 bp fragment ( X1 region ) of the PRB - 1b promoter , located between positions - 213 and - 141 , was sufficient to confer ethylene responsiveness to the reporter gene .", + "entities": [ + "PRB - 1b promoter" + ] + }, + { + "id": "9623", + "type": "gene", + "text": "Thus , hGRbeta potentially functions as a dominant negative inhibitor of hGRalpha activity .", + "entities": [ + "hGRbeta", + "hGRalpha" + ] + }, + { + "id": "9624", + "type": "gene", + "text": "The orf61 gene product , when expressed from an exogenous promoter , inhibited int - mediated integration at the chromosomal attB site .", + "entities": [ + "orf61 gene product", + "int", + "chromosomal attB site" + ] + }, + { + "id": "9625", + "type": "gene", + "text": "Radiolabeled recombinant TARC specifically bound to T cell lines and peripheral T cells but not to monocytes or granulocytes .", + "entities": [ + "recombinant TARC" + ] + }, + { + "id": "9626", + "type": "gene", + "text": "RESULTS : Basal plasma IGF - I levels as well as body mass index ( BMI ) were lower in amenorrheic patients than in healthy controls .", + "entities": [ + "plasma IGF - I" + ] + }, + { + "id": "9627", + "type": "gene", + "text": "Postoperative serum ACTH levels were normal .", + "entities": [ + "ACTH" + ] + }, + { + "id": "9628", + "type": "gene", + "text": "Unilateral naris occlusion and the rat accessory olfactory bulb .", + "entities": [] + }, + { + "id": "9629", + "type": "gene", + "text": "Cyclosporine treatment for intractable polymyositis .", + "entities": [] + }, + { + "id": "9630", + "type": "gene", + "text": "Kindling of the primary visual cortex ( VC ) was compared with that of the amygdala in cats .", + "entities": [] + }, + { + "id": "9631", + "type": "gene", + "text": "Immunelectrophoretic pattern of Wassermann reagin and comparison of the appearance time between RPCF and FTA antibodies", + "entities": [ + "RPCF" + ] + }, + { + "id": "9632", + "type": "gene", + "text": "GH deficiency may be absolute , but often is not and the diagnosis may be complicated by a constellation of physical and hormonal findings that are along a spectrum from low normal GH sufficiency to absent GH secretion .", + "entities": [ + "GH", + "GH", + "GH" + ] + }, + { + "id": "9633", + "type": "gene", + "text": "Restoration of impaired immune functions in aging animals .", + "entities": [] + }, + { + "id": "9634", + "type": "gene", + "text": "This mode of ternary complex formation is in contrast to the one seen in the promoter of the c - fos protooncogene , where formation of the ternary complex is dependent on the prior assembly of the serum response factor - DNA binary complex .", + "entities": [ + "c - fos protooncogene", + "serum response factor - DNA binary complex" + ] + }, + { + "id": "9635", + "type": "gene", + "text": "The logistic regression analysis of the manual method ( percentage normal morphology ) and IVOS indicated that both were predictors of fertilization .", + "entities": [] + }, + { + "id": "9636", + "type": "gene", + "text": "Encouraged by a Dutch study using etidronate / fluoride in corticoid - induced osteoporosis , we performed a pilot study in 33 men with severe established primary osteoporosis giving cyclically etidronate for 14 days followed by fluoride plus calcium / vitamin D for 76 days .", + "entities": [] + }, + { + "id": "9637", + "type": "gene", + "text": "The same trend was noted between YG 4 . 5 heifers and YG 5 . 5 steers , indicating a sex - related deposition of seam fat in fed cattle .", + "entities": [] + }, + { + "id": "9638", + "type": "gene", + "text": "The Oct - 2 glutamine - rich and proline - rich activation domains can synergize with each other or duplicates of themselves to activate transcription .", + "entities": [ + "Oct - 2" + ] + }, + { + "id": "9639", + "type": "gene", + "text": "T - cell hybridomas , thymocytes , and T cells can be induced to undergo apoptotic cell death by activation through the T - cell receptor .", + "entities": [ + "T - cell receptor" + ] + }, + { + "id": "9640", + "type": "gene", + "text": "Effect of heat treatments on the meltability of cheeses .", + "entities": [] + }, + { + "id": "9641", + "type": "gene", + "text": "Consciousness is connected with attention , working memory and perception .", + "entities": [] + }, + { + "id": "9642", + "type": "gene", + "text": "To determine whether mononuclear cell secretory products contribute to the changes in bone turnover that characterize the development of postmenopausal osteoporosis , we evaluated the effects of oophorectomy and subsequent estrogen replacement on the spontaneous secretion of interleukin 1 ( IL - 1 ) and tumor necrosis factor alpha ( TNF - alpha ) and on the phytohemagglutinin A - induced secretion of granulocyte - macrophage colony - stimulating factor ( GM - CSF ) from peripheral blood mononuclear cells .", + "entities": [ + "interleukin 1", + "IL - 1", + "tumor necrosis factor alpha", + "TNF - alpha", + "phytohemagglutinin A", + "granulocyte - macrophage colony - stimulating factor", + "GM - CSF" + ] + }, + { + "id": "9643", + "type": "gene", + "text": "Alternative processing of the tryptophanyl - tRNA synthetase mRNA from interferon - treated human cells .", + "entities": [ + "tryptophanyl - tRNA synthetase mRNA", + "interferon" + ] + }, + { + "id": "9644", + "type": "gene", + "text": "Another ORF , dda . 2 located between modA and dda , shares sequence similarity with sigma70 , and we call it srd .", + "entities": [ + "dda . 2", + "modA", + "dda", + "sigma70", + "srd" + ] + }, + { + "id": "9645", + "type": "gene", + "text": "Intriguingly , three hypomorphic Scm mutations , which map within an mbt repeat , interact with PcG mutations more strongly than do Scm null alleles .", + "entities": [ + "Scm", + "mbt repeat", + "PcG mutations", + "Scm" + ] + }, + { + "id": "9646", + "type": "gene", + "text": "Clone 4c ( 2681 bp ) had a coding region identical to that of clone 22c but it included a putative intron of 959 bp .", + "entities": [] + }, + { + "id": "9647", + "type": "gene", + "text": "However , when , where and how the DSPP is cleaved into DSP and DPP is not clear .", + "entities": [ + "DSPP", + "DSP", + "DPP" + ] + }, + { + "id": "9648", + "type": "gene", + "text": "This is the first example of a eukaryotic transcription factor complex containing both a MADS - box and a forkhead protein , and it has important implications for the regulation of mammalian gene expression .", + "entities": [ + "MADS - box", + "forkhead protein" + ] + }, + { + "id": "9649", + "type": "gene", + "text": "Ophthalmosonographic evaluation of blood flow velocity in arteriocavernous fistula", + "entities": [] + }, + { + "id": "9650", + "type": "gene", + "text": "We show here that , despite their structural and functional similarities , the pop1 and pop2 genes fail to complement each other ' s deletion phenotypes , indicating that they perform non - redundant , but potentially interdependent , functions in proteolysis .", + "entities": [ + "pop1", + "pop2 genes" + ] + }, + { + "id": "9651", + "type": "gene", + "text": "Carbonic anhydrase V ( CA V ) is expressed in mitochondrial matrix in liver and several other tissues .", + "entities": [ + "Carbonic anhydrase V", + "CA V" + ] + }, + { + "id": "9652", + "type": "gene", + "text": "Thus it appears that the management of blood , including washing is of great importance .", + "entities": [] + }, + { + "id": "9653", + "type": "gene", + "text": "Anastrozole is the first aromatase inhibitor to show a significant survival advantage over megestrol acetate in post - menopausal women with advanced breast cancer .", + "entities": [ + "aromatase" + ] + }, + { + "id": "9654", + "type": "gene", + "text": "Immunological testing was performed on all brewery workers and some control volunteers using skin prick testing with hops , barley , and yeast antigens as well as other nonoccupational allergens , and by determining total serum IgE levels .", + "entities": [ + "serum IgE" + ] + }, + { + "id": "9655", + "type": "gene", + "text": "A . , Slatkin , D .", + "entities": [] + }, + { + "id": "9656", + "type": "gene", + "text": "Prognostic value of a treadmill exercise score in symptomatic patients with nonspecific ST - T abnormalities on resting ECG .", + "entities": [] + }, + { + "id": "9657", + "type": "gene", + "text": "Fluid ( AVLF ) 31 .", + "entities": [] + }, + { + "id": "9658", + "type": "gene", + "text": "Estrogen replacement , either as 17 beta - estradiol or beta - estradiol - 3 - benzoate via subcutaneous Silastic capsules , was associated with elevated rates of heat production and dry heat loss relative to untreated ovariectomized controls .", + "entities": [] + }, + { + "id": "9659", + "type": "gene", + "text": "Bifunctionality of the AcMNPV homologous region sequence ( hr1 ) : enhancer and ori functions have different sequence requirements .", + "entities": [ + "AcMNPV homologous region sequence", + "hr1" + ] + }, + { + "id": "9660", + "type": "gene", + "text": "The values were consistently lower ( P less than 0 . 01 ) during summer ( 3 . 79 + / - 0 . 13 micrograms / 100 ml ) , as compared to winter ( 5 . 06 + / - 0 . 27 ) .", + "entities": [] + }, + { + "id": "9661", + "type": "gene", + "text": "Using mutated IL2R alpha promoter constructs in transient transfection and DNA binding assays , we now demonstrate that sequences located immediately upstream and downstream of the kappa B enhancer also contribute to the regulation of IL2R alpha gene expression .", + "entities": [ + "mutated IL2R alpha promoter constructs", + "kappa B enhancer", + "IL2R alpha gene" + ] + }, + { + "id": "9662", + "type": "gene", + "text": "The importance of hepatitis C virus ( HCV ) infection as a cause of chronic liver disease has become clear with the introduction of serologic detection methods .", + "entities": [] + }, + { + "id": "9663", + "type": "gene", + "text": "Among unusual features , we report numerous large G + C - rich conserved sequences located in the first intron .", + "entities": [] + }, + { + "id": "9664", + "type": "gene", + "text": "Moreover , it also discusses the effects of antihypertensive drugs currently regarded as first - choice agents , i . e . calcium antagonists and the angiotensin converting enzyme inhibitors , on intrarenal hemodynamics .", + "entities": [ + "angiotensin converting enzyme" + ] + }, + { + "id": "9665", + "type": "gene", + "text": "The progress of morphological research on the parabrachial nucleus", + "entities": [] + }, + { + "id": "9666", + "type": "gene", + "text": "Recombinant Leishmania surface glycoprotein GP63 is secreted in the baculovirus expression system as a latent metalloproteinase .", + "entities": [ + "Recombinant Leishmania surface glycoprotein GP63", + "metalloproteinase" + ] + }, + { + "id": "9667", + "type": "gene", + "text": "Female but not male mortalities were significantly higher for cake - fed rats than for those fed diet 41B .", + "entities": [] + }, + { + "id": "9668", + "type": "gene", + "text": "Examination of neurohumoral factors revealed a hyperactive sympathetic nervous system and an increase in plasma renin activity .", + "entities": [ + "renin" + ] + }, + { + "id": "9669", + "type": "gene", + "text": "In addition , the hGCSFR gene was chromosomally localized by Southern blot analysis of its segregation pattern in a panel of rodent - human hybrid DNAs using the radiolabeled cDNA probe .", + "entities": [ + "hGCSFR gene" + ] + }, + { + "id": "9670", + "type": "gene", + "text": "The 4 days dexamethasone suppression test showed more than 80 % suppression of dehydroepiandrosterone - sulphate and a variable ( 40 - 60 % ) reduction of testosterone and androstenedione levels .", + "entities": [] + }, + { + "id": "9671", + "type": "gene", + "text": "Identification of the plakoglobin - binding domain in desmoglein and its role in plaque assembly and intermediate filament anchorage .", + "entities": [ + "plakoglobin", + "desmoglein" + ] + }, + { + "id": "9672", + "type": "gene", + "text": "E2F is a heterodimeric complex consisting of E2F family members ( 1 - 5 ) and DP proteins ( 1 - 3 ) .", + "entities": [ + "E2F", + "E2F family members ( 1 - 5 )", + "DP proteins ( 1 - 3 )" + ] + }, + { + "id": "9673", + "type": "gene", + "text": "The side - to - side difference was statistically significant at EXT 30 degrees / s and 60 degrees / s ( p < 0 . 05 ) .", + "entities": [] + }, + { + "id": "9674", + "type": "gene", + "text": "To map this regulatory serine phosphorylation site we developed a baculovirus - mediated expression system for wild - type annexin II and for a series of annexin II mutants which contained substitutions in one or more serine residues present in the N - terminal domain .", + "entities": [ + "wild - type annexin II", + "annexin II mutants" + ] + }, + { + "id": "9675", + "type": "gene", + "text": "Five of 10 scars studied decreased at least 50 % in linear dimensions .", + "entities": [] + }, + { + "id": "9676", + "type": "gene", + "text": "Expression of ME31B cDNA in S . pombe suppresses the ste13 mutation .", + "entities": [ + "ME31B cDNA", + "ste13" + ] + }, + { + "id": "9677", + "type": "gene", + "text": "An endogenous mammalian regulator of this process , named Usurpin , has been identified ( aliases for Usurpin include CASH , Casper , CLARP , FLAME - 1 , FLIP , I - FLICE and MRIT ) .", + "entities": [ + "Usurpin", + "Usurpin", + "CASH", + "Casper", + "CLARP", + "FLAME - 1", + "FLIP", + "I - FLICE", + "MRIT" + ] + }, + { + "id": "9678", + "type": "gene", + "text": "A second large group of disorders in pregnancy is caused by effects of infections of the mother without pathogens being transmitted to the embryo or the placenta .", + "entities": [] + }, + { + "id": "9679", + "type": "gene", + "text": "Childhood misbehavior and the risk of injecting drug use .", + "entities": [] + }, + { + "id": "9680", + "type": "gene", + "text": "In the DNAs of all Ph1 - positive chronic myelocytic leukemia patients studied to date , a breakpoint on chromosome 22 ( the Ph1 chromosome ) can be demonstrated with a probe from the bcr ( breakpoint cluster region ) .", + "entities": [ + "bcr", + "breakpoint cluster region" + ] + }, + { + "id": "9681", + "type": "gene", + "text": "Eukaryotic initiation factor 3 ( eIF3 ) is a large multisubunit complex that stabilizes the ternary complex , eIF2 x GTP x tRNA ( Met ) i and promotes mRNA binding to the 40 S ribosomal subunit .", + "entities": [ + "Eukaryotic initiation factor 3", + "eIF3", + "eIF2", + "tRNA ( Met ) i", + "40 S ribosomal subunit" + ] + }, + { + "id": "9682", + "type": "gene", + "text": "eIF3 also functions as a ribosome subunit anti - association factor .", + "entities": [ + "eIF3" + ] + }, + { + "id": "9683", + "type": "gene", + "text": "Cells lacking p116 exhibit a striking defect in the formation of these macropinocytic structures , a concomitant reduction in the rate of fluid phase pinocytosis , a significant decrease in the efficiency of chemotactic aggregation , and a decrease in cellular F - actin content .", + "entities": [ + "p116", + "F - actin" + ] + }, + { + "id": "9684", + "type": "gene", + "text": "Analysis of nucleotide sequence of the rightmost 43 kbp of herpesvirus saimiri ( HVS ) L - DNA : general conservation of genetic organization between HVS and Epstein - Barr virus .", + "entities": [] + }, + { + "id": "9685", + "type": "gene", + "text": "Pigmentary rhythms as indicators of neurosecretion .", + "entities": [] + }, + { + "id": "9686", + "type": "gene", + "text": "In vitro expression levels of the different plasmids differed by as much as tenfold .", + "entities": [] + }, + { + "id": "9687", + "type": "gene", + "text": "When mixed with aqueous solutions of TMT - 55 , aqueous solutions of either reagent - grade zinc , cadmium , or lead salts precipitate crystalline \" Zn - TMT \" , amorphous or crystalline \" Cd - TMT \" or amorphous \" Pb - TMT \" ( M3 [ S3C3N3 ] 2 . nH2O , where M = Cd2 + , Pb2 + , and Zn2 + and n > or = 0 ) that may eventually crystallize if stored in air .", + "entities": [] + }, + { + "id": "9688", + "type": "gene", + "text": "In addition , CaMig1 formed specific complexes with the URS1 region of the S . cerevisiae FBP1 gene .", + "entities": [ + "CaMig1", + "S . cerevisiae FBP1 gene" + ] + }, + { + "id": "9689", + "type": "gene", + "text": "These studies support the view that HMG I ( Y ) is an important cofactor for HLA - DRA gene activation by Oct - 2A and provide insights into its mechanism of action .", + "entities": [ + "HMG I ( Y )", + "HLA - DRA gene", + "Oct - 2A" + ] + }, + { + "id": "9690", + "type": "gene", + "text": "Catch - up growth and craniofacial dimensions following administration of the antineoplastic agent vincristine to young rats .", + "entities": [] + }, + { + "id": "9691", + "type": "gene", + "text": "When the high affinity hnRNP A1 binding site was inserted into the beta - globin reporter , Rev was able to increase the cytoplasmic levels of unspliced mRNAs to 14 % .", + "entities": [ + "hnRNP A1 binding site", + "beta - globin reporter", + "Rev" + ] + }, + { + "id": "9692", + "type": "gene", + "text": "We report the results of a detailed policy analysis comparing 2 CJD - related decisions : a 1995 recall of blood from a donor with classic CJD and the 1999 decision to defer donations from individuals with a 6 - month travel history to the UK between 1980 and 1996 due to concerns related to variant CJD .", + "entities": [] + }, + { + "id": "9693", + "type": "gene", + "text": "GGS1 is the same gene as TPS1 which was identified as encoding a subunit of the trehalose - 6 - phosphate synthase / phosphatase complex and it is allelic to the fdp1 , byp1 , glc6 and cif1 mutations .", + "entities": [ + "GGS1", + "TPS1", + "trehalose - 6 - phosphate synthase / phosphatase complex", + "fdp1", + "byp1", + "glc6" + ] + }, + { + "id": "9694", + "type": "gene", + "text": "Interferon type I in protective body reactions in an experimental Klebsiella infection", + "entities": [ + "Interferon type I" + ] + }, + { + "id": "9695", + "type": "gene", + "text": "The following markers were looked for in the serum , skin and liver of all patients with chronic hepatitis : HBV ( HBs Ag and HBe Ag , anti - HBs , anti - HBe and anti - HBc in the serum , HBs and HBc Ag in the liver ) ; non - A non - B ( non - A , non - B Ag and antibody , anti non - A non - Bc in the serum , non - A , non - Bc Ag in the liver ) .", + "entities": [ + "HBs Ag", + "HBe Ag", + "anti - HBs", + "anti - HBe", + "anti - HBc", + "HBs and HBc Ag", + "non - A non - B", + "non - A , non - B Ag and antibody", + "anti non - A non - Bc", + "non - A , non - Bc Ag" + ] + }, + { + "id": "9696", + "type": "gene", + "text": "Cloning and sequence analyses revealed a second cDNA with a 95 - nt deletion in the region coding for the putative second intracellular loop and the fourth transmembrane domain of the 5 - HT2C - R .", + "entities": [ + "5 - HT2C - R" + ] + }, + { + "id": "9697", + "type": "gene", + "text": "METHODS : T2 * - weighted , three - dimensional gradient - echo images were acquired by exploiting the magnetic susceptibility difference between oxygenated and deoxygenated hemoglobin in the vasculature and microvasculature .", + "entities": [ + "hemoglobin" + ] + }, + { + "id": "9698", + "type": "gene", + "text": "These fusion proteins also allowed the localization of the transcriptional activation and DNA binding domains of the ToxR protein to its cytoplasmically located N - terminal portion .", + "entities": [ + "ToxR protein" + ] + }, + { + "id": "9699", + "type": "gene", + "text": "Second , the wild - type m8 3 ' UTR strongly reduces accumulation of heterologous transcripts in vivo , an activity that requires its K box sequences .", + "entities": [ + "wild - type m8 3 ' UTR" + ] + }, + { + "id": "9700", + "type": "gene", + "text": "Technetium - 99m stannous pyrophosphate myocardial scintigrams were obtained in 138 clinically stable patients 32 . 7 + / - 47 . 3 weeks ( range 6 to 260 ) after acute myocardial infarction .", + "entities": [] + }, + { + "id": "9701", + "type": "gene", + "text": "In view of these results , simultaneous pancreas - kidney transplantation appears to be the treatment of choice for Type I diabetic patients .", + "entities": [] + }, + { + "id": "9702", + "type": "gene", + "text": "Molecular dissection of the multimeric CD3 - TCR complex revealed that at least two associated polypeptides , CD3 zeta and CD3 epsilon , autonomously couple antigenic recognition event to early and late events of the intracytoplasmic activation cascade .", + "entities": [ + "CD3", + "TCR", + "CD3 zeta", + "CD3 epsilon" + ] + }, + { + "id": "9703", + "type": "gene", + "text": "Single tooth replacement with the aid of the ITI ( International Team fur Implantologie ) type F hollow - cylinder implant", + "entities": [] + }, + { + "id": "9704", + "type": "gene", + "text": "Existence and uniqueness of solutions of the appropriate boundary value problems are established , in the case of small permeability coefficients and transport rates , or large diffusion coefficients and small resistance to flow constants .", + "entities": [] + }, + { + "id": "9705", + "type": "gene", + "text": "This study was undertaken to assess the effects of hypothermia and chemical cardioplegia on the functional recovery of hypertrophied non - failing rat hearts subjected to an extended period of global ischaemia .", + "entities": [] + }, + { + "id": "9706", + "type": "gene", + "text": "Therefore , we have identified a cis - acting element , the E1 E - box , located in the GAP - 43 promoter region that modulates either positively or negatively the expression of the GAP - 43 gene depending on which E - box - binding proteins occupy this site .", + "entities": [ + "GAP - 43", + "GAP - 43 gene", + "E - box - binding proteins" + ] + }, + { + "id": "9707", + "type": "gene", + "text": "We have examined the ability of various NF - kappa B subunits to bind to , and activate transcription from , the IL - 8 promoter .", + "entities": [ + "NF - kappa B subunits", + "IL - 8 promoter" + ] + }, + { + "id": "9708", + "type": "gene", + "text": "Resting plasma norepinephrine ( NE ) and epinephrine ( E ) levels were lower during active therapy than 2 wk after withdrawal ( guanfacine and control : plasma NE , 0 . 27 + / - 0 . 03 / 0 . 64 + / - 0 . 13 ng / ml ; plasma E , 0 . 09 + / - 0 . 02 / 0 . 17 + / - 0 . 05 ng / ml ) .", + "entities": [] + }, + { + "id": "9709", + "type": "gene", + "text": "The clinical relevance of these findings is strengthened by the observation that similar results were obtained when P . HCl was given by the intravenous route .", + "entities": [] + }, + { + "id": "9710", + "type": "gene", + "text": "Intraperitoneal administration of L - 5 - hydroxytryptophan ( L - 5 - HTP ) at doses of 25 to 100 mg / kg dramatically increase defecation in mice .", + "entities": [] + }, + { + "id": "9711", + "type": "gene", + "text": "Alignment of different cDNAs of the NR5A2 ( hB1F ) gene with the genomic sequence facilitated the delineation of its structural organization , which spans over 150 kb and consists of eight exons interrupted by seven introns .", + "entities": [ + "NR5A2", + "hB1F" + ] + }, + { + "id": "9712", + "type": "gene", + "text": "Chicken sterol carrier protein 2 / sterol carrier protein x : cDNA cloning reveals evolutionary conservation of structure and regulated expression .", + "entities": [ + "sterol carrier protein 2", + "sterol carrier protein x" + ] + }, + { + "id": "9713", + "type": "gene", + "text": "Its clearance has been found to be decreased ( typically by around 25 % , but often by far more ) by erythromycin , troleandomycin ( triacetyloleandomycin ) , roxithromycin , enoxacin , ciprofloxacin , pefloxacin , norfloxacin , ofloxacin , fluoroquinolone T - 3262 , pipemidic acid , cimetidine , etintidine , propranolol , verapamil , diltiazem , nifedipine , furosemide ( frusemide ) , at least some anovulent agents , viloxazine , allopurinol , ticlopidine , idrocilamide , thiabendazole , disulfiram , influenza - and BCG - vaccination , interferon , and caffeine ( half - life increase ) .", + "entities": [ + "interferon" + ] + }, + { + "id": "9714", + "type": "gene", + "text": "Breitbart , L .", + "entities": [] + }, + { + "id": "9715", + "type": "gene", + "text": "The mean percentage of linoleic acid in the triglycerides of the subcutaneous adipose tissue ( PLASAT ) of these subjects was substantially higher than that in a similar group examined in 1975 - 1976 .", + "entities": [] + }, + { + "id": "9716", + "type": "gene", + "text": "The phi AP3 factor is a nuclear phosphoprotein ; the extent of its phosphorylation is regulated during the cell cycle .", + "entities": [ + "phi AP3 factor" + ] + }, + { + "id": "9717", + "type": "gene", + "text": "Previously , we reported the sequence of the gene encoding human K14 ( D .", + "entities": [ + "gene encoding human K14" + ] + }, + { + "id": "9718", + "type": "gene", + "text": "Distinguishing roles of the membrane - cytoskeleton and cadherin mediated cell - cell adhesion in generating different Na + , K ( + ) - ATPase distributions in polarized epithelia .", + "entities": [ + "cadherin", + "Na + , K ( + ) - ATPase" + ] + }, + { + "id": "9719", + "type": "gene", + "text": "Consistent with our model , CTCF binding is abolished by DNA methylation .", + "entities": [ + "CTCF" + ] + }, + { + "id": "9720", + "type": "gene", + "text": "The correcting action of tropatepine hydrochloride upon the extrapyramidal effects induced by neuroleptics has been studied in 32 acute psychotic states .", + "entities": [] + }, + { + "id": "9721", + "type": "gene", + "text": "The neural mechanism of parkinsonian motor symptoms , i . e . , rigidity , tremor and akinesia , which are the result of nigrostriatal dopamine deficiency , is interpreted from long - term observations on the effect of surgical and pharmacological treatment of the disease in relation to the neuropathological findings within the substantia nigra zona compacta ( SNc ) .", + "entities": [] + }, + { + "id": "9722", + "type": "gene", + "text": "In addition , we found differences in the binding of nuclear factors from shoots versus from roots , in agreement with the different activities of the promoter in these two organs .", + "entities": [] + }, + { + "id": "9723", + "type": "gene", + "text": "The ns2 gene comprises an open reading frame ( ORF ) encoding a putative nonstructural ( ns ) protein of 279 amino acids with a predicted molecular mass of 32 - kDa .", + "entities": [ + "ns2 gene" + ] + }, + { + "id": "9724", + "type": "gene", + "text": "However , a correlation was observed between SF levels of IL - 8 with those of lactate , LDH , beta 2 - microglobulin and glucose .", + "entities": [ + "IL - 8", + "LDH", + "beta 2 - microglobulin" + ] + }, + { + "id": "9725", + "type": "gene", + "text": "We describe a total of 39 DEAH helicases in these four species .", + "entities": [ + "DEAH helicases" + ] + }, + { + "id": "9726", + "type": "gene", + "text": "Our analysis of nonsense mutations indicates that the C terminus of eIF2Bepsilon ( residues 518 to 712 ) is required for both catalytic activity and interaction with eIF2 .", + "entities": [ + "eIF2Bepsilon ( residues 518 to 712 )", + "eIF2" + ] + }, + { + "id": "9727", + "type": "gene", + "text": "Experiments on 23 white rats and 10 guinea pigs have shown that preliminarily indomethacin - induced inhibition of prostaglandins synthesis prevented development of pulmonary oedema , evoked by heterologous serum in rats and by vagotomy in guinea pigs .", + "entities": [] + }, + { + "id": "9728", + "type": "gene", + "text": "OBJECTIVE : To evaluate the accuracy of working casts for crown and bridge restorations made from twin mix putty / wash silicone elastomeric impression materials using different types of stock tray .", + "entities": [] + }, + { + "id": "9729", + "type": "gene", + "text": "Thus , SPECT was not as sensitive as PET in this activation task .", + "entities": [] + }, + { + "id": "9730", + "type": "gene", + "text": "A .", + "entities": [] + }, + { + "id": "9731", + "type": "gene", + "text": "This mutant was identified by screening with a TGF - beta - inducible vector a series of mink lung epithelial cell clones that have normal TGF - beta binding activity but have lost antiproliferative and transcriptional responses to TGF - beta .", + "entities": [ + "TGF - beta", + "TGF - beta", + "TGF - beta" + ] + }, + { + "id": "9732", + "type": "gene", + "text": "Regulation at 37 degrees C , therefore , involves the action of three protein kinase cascades that repress HSF1 through phosphorylation of serine residues 303 , 307 , and 363 and may promote growth by suppressing the heat shock response .", + "entities": [ + "HSF1" + ] + }, + { + "id": "9733", + "type": "gene", + "text": "To characterize the gene products , the cvaA gene was subcloned and expressed under the control of T7 RNA polymerase promoter .", + "entities": [ + "cvaA gene", + "T7 RNA polymerase promoter" + ] + }, + { + "id": "9734", + "type": "gene", + "text": "We have now located the 5 ' ends of the two remaining late mRNAs .", + "entities": [] + }, + { + "id": "9735", + "type": "gene", + "text": "In about one third of the cases this operation results in tonal and vocal improvement for patients suffering from progressive perceptive deafness .", + "entities": [] + }, + { + "id": "9736", + "type": "gene", + "text": "In the duodenum a small part of the administered dose was transformed to 3H - alpha - acetyldigoxin .", + "entities": [] + }, + { + "id": "9737", + "type": "gene", + "text": "Estimation of renin secretion rate and renal plasma flow from peripheral and renal vein renin levels .", + "entities": [ + "renin", + "renal vein renin" + ] + }, + { + "id": "9738", + "type": "gene", + "text": "By stepwise linear multiple regression analysis , ionized magnesium was significantly related to cyclosporin trough level and total cholesterol but not to serum creatinine , time after transplant or the dose of cyclosporin .", + "entities": [] + }, + { + "id": "9739", + "type": "gene", + "text": "In an attempt to reduce the incidence of NSAID - induced gastrointestinal lesions , the following approaches have been proposed : ( i ) use of the prostaglandin analogue misoprostol , which is an antiulcer drug which has been proven to be as effective in the prevention of NSAID - induced gastric and duodenal ulcers as in the reduction of serious upper gastrointestinal complications ; ( ii ) histamine H2 receptor antagonists ( H2 antagonists ) , e . g . ranitidine , cimetidine and famotidine , which are useful in the prevention of NSAID - induced duodenal ulcers during long term treatment , but not in the prevention of NSAID - induced gastric ulcers ; ( iii ) proton pump inhibitors , e . g omeprazole , and pantoprazole , whose efficacy in preventing NSAID - associated ulcers has been recently demonstrated ; and ( iv ) barrier agents , e . g . sucralfate , which cannot be recommended as prophylactic agents to prevent NSAID - induced gastropathy .", + "entities": [ + "histamine H2 receptor" + ] + }, + { + "id": "9740", + "type": "gene", + "text": "UAS1 is the binding site for the transcriptional regulator Adr1p .", + "entities": [ + "Adr1p" + ] + }, + { + "id": "9741", + "type": "gene", + "text": "Further studies on a \" new \" human isoprecipitin system ( Australia antigen ) .", + "entities": [ + "isoprecipitin" + ] + }, + { + "id": "9742", + "type": "gene", + "text": "Forced expression of BZAP45 strongly stimulates H4 promoter ( nt - 215 to - 1 ) / CAT reporter gene activity .", + "entities": [ + "BZAP45", + "H4 promoter", + "CAT" + ] + }, + { + "id": "9743", + "type": "gene", + "text": "Focused beams of classical light ablate elements of the cell division machinery and switch the beating of hearts on a cellular basis .", + "entities": [] + }, + { + "id": "9744", + "type": "gene", + "text": "Comparison of the sequences of attP , attB and bacteria - prophage junctions attL and attR showed a 26 bp common core sequence , where recombination takes place , near the 5 ' end of the integrase gene .", + "entities": [ + "attP", + "attB", + "attL", + "attR", + "integrase gene" + ] + }, + { + "id": "9745", + "type": "gene", + "text": "We report here the identification of HSF in the fission yeast Schizosaccharomyces pombe .", + "entities": [ + "HSF" + ] + }, + { + "id": "9746", + "type": "gene", + "text": "This compares favorably to results of similarly sized melanomas treated by enucleation .", + "entities": [] + }, + { + "id": "9747", + "type": "gene", + "text": "Furthermore , the amount of tRNA ( 3Lys ) that was placed onto viral RNA in mutated viruses was significantly less than that placed in the wild - type virus .", + "entities": [ + "tRNA ( 3Lys )" + ] + }, + { + "id": "9748", + "type": "gene", + "text": "Prazosin alone was effective in volume responsive patients at a dose of 5 + / - 1 . 0 mg daily .", + "entities": [] + }, + { + "id": "9749", + "type": "gene", + "text": "BRCA1 , a familial breast and ovarian cancer susceptibility gene encodes nuclear phosphoproteins that function as tumor suppressors in human breast cancer cells .", + "entities": [ + "BRCA1" + ] + }, + { + "id": "9750", + "type": "gene", + "text": "Anatomy of the RNA and gene products of MC29 and MH2 , two defective avian tumor viruses causing acute leukemia and carcinoma : evidence for a new class of transforming genes .", + "entities": [] + }, + { + "id": "9751", + "type": "gene", + "text": "Patients receiving VPA showed differences in attention , visuomotor performance , verbal span and sensory discrimination tasks at T1 , in visuomotor performance at T2 and in spatial span at T3 , whereas no differences were detected at T4 .", + "entities": [] + }, + { + "id": "9752", + "type": "gene", + "text": "We studied GSH - Px enzyme activity in serum after acute myocardial infarction ( AMI ) and unstable angina pectoris ( UAP ) .", + "entities": [] + }, + { + "id": "9753", + "type": "gene", + "text": "Finally , a role for NF - kappaB in preventing apoptosis induced by ER calcium release was demonstrated by data showing that sAPPalpha prevents thapsigargin - induced apoptosis , an effect blocked by kappaB decoy DNA .", + "entities": [ + "NF - kappaB", + "sAPPalpha", + "kappaB" + ] + }, + { + "id": "9754", + "type": "gene", + "text": "All three genes have been mapped precisely to a small region on human chromosome 16p12 . 1 - p11 . 2 ( homologous to mouse chromosome 7 ) , using somatic cell hybrids and cosmid clones .", + "entities": [] + }, + { + "id": "9755", + "type": "gene", + "text": "Significance of the biopsy site of the latissimus dorsi muscle for fiber typing .", + "entities": [] + }, + { + "id": "9756", + "type": "gene", + "text": "As an application of reverse genetics , we introduced one nucleotide change ( UCU to ACU ) to immediate downstream of the RNA - editing site of the V gene in the full - length hPIV2 cDNA and were able to obtain infectious viruses [ rPIV2V ( - ) ] from the cDNA .", + "entities": [ + "V gene" + ] + }, + { + "id": "9757", + "type": "gene", + "text": "Roles of the Candida albicans mitogen - activated protein kinase homolog , Cek1p , in hyphal development and systemic candidiasis .", + "entities": [ + "Candida albicans mitogen - activated protein kinase homolog", + "Cek1p" + ] + }, + { + "id": "9758", + "type": "gene", + "text": "Deletion mapping of the human presenilin - 1 ( PS1 ) promoter delineated the most active fragment from - 118 to + 178 in relation to the transcription start site mapped in this study , in both human neuroblastoma SK - N - SH and hepatoma HepG2 cells .", + "entities": [ + "human presenilin - 1", + "PS1" + ] + }, + { + "id": "9759", + "type": "gene", + "text": "In about 770 bp upstream region of Spam1 that has been cloned and sequenced , multiple transcription factor binding sites including a CRE ( cAMP - responsive element ) were found .", + "entities": [ + "Spam1" + ] + }, + { + "id": "9760", + "type": "gene", + "text": "Vaccinia virus - expressed , purified full - length HPV - 16 and BPV - 1 E2 proteins bound a consensus E2 site with high specific affinities ( Kd = approximately 10 ( - 9 ) M ) and stimulated in vitro transcription up to six - to eightfold .", + "entities": [ + "full - length HPV - 16 and BPV - 1 E2 proteins", + "E2 site" + ] + }, + { + "id": "9761", + "type": "gene", + "text": "5 ) Before and ten days after DOTC infusion , laboratory tests for liver and renal functions and blood were performed .", + "entities": [] + }, + { + "id": "9762", + "type": "gene", + "text": "Clinical aspects of early increase in serum gamma - glutamyl transferase in cerebral infarction .", + "entities": [ + "gamma - glutamyl transferase" + ] + }, + { + "id": "9763", + "type": "gene", + "text": "The P mRNA also contains a third ORF for the V protein , although it is unclear how or whether this ORF is accessed .", + "entities": [ + "P mRNA", + "V protein" + ] + }, + { + "id": "9764", + "type": "gene", + "text": "Thereafter , the aggregation rose to the initial 100 % value 4 h after drug application and remained at this level during the observation period . ( ABSTRACT TRUNCATED AT 250 WORDS )", + "entities": [] + }, + { + "id": "9765", + "type": "gene", + "text": "RESULTS : The bilinear model provided a significantly better fit to the acuity outcome data .", + "entities": [] + }, + { + "id": "9766", + "type": "gene", + "text": "We have used these modified assay conditions to extend studies on the transposition pathway .", + "entities": [] + }, + { + "id": "9767", + "type": "gene", + "text": "The p36 gene is at least 22 kb in length and has a coding sequence of approximately 1 kb , representing only 4 . 5 % of the gene . ( ABSTRACT TRUNCATED AT 250 WORDS )", + "entities": [ + "p36 gene" + ] + }, + { + "id": "9768", + "type": "gene", + "text": "Sequence analysis of these genes and their surrounding sequences are presented and compared with other known tRNA genes from plant mitochondria .", + "entities": [] + }, + { + "id": "9769", + "type": "gene", + "text": "Analysis of the E2F1 gene promoter showed that the - 146 to - 54 region was required for E2 - responsiveness in transient transfection assays , and subsequent deletion / mutation analysis showed that a single upstream GC - rich and two downstream CCAAT - binding sites were required for transactivation by E2 .", + "entities": [ + "E2F1 gene promoter", + "E2", + "E2" + ] + }, + { + "id": "9770", + "type": "gene", + "text": "Five experiments examined the influence of opiate antagonists on both the short - term analgesic reaction resulting 30 min after exposure to inescapable shock and the long - term analgesic reaction resulting after reexposure to shock 24 hr after inescapable shock exposure .", + "entities": [] + }, + { + "id": "9771", + "type": "gene", + "text": "The overexpressed His6 - tagged GrsA derivatives were affinity - purified , and the catalytic properties of the deletion mutants were examined by biochemical studies including ATP - dependent amino acid activation , carboxyl thioester formation , and the ability to racemize the covalently bound phenylalanine from L - to the D - isomer .", + "entities": [ + "His6 - tagged GrsA derivatives" + ] + }, + { + "id": "9772", + "type": "gene", + "text": "None of these organic manifestations was discovered by scintigraphic means .", + "entities": [] + }, + { + "id": "9773", + "type": "gene", + "text": "This supports previous arguments for the improbability of biological effects at UHF frequencies unless a mechanism can be found for accumulating energy over time and space and focussing it .", + "entities": [] + }, + { + "id": "9774", + "type": "gene", + "text": "The transcription initiation site was determined to occur 66 bp upstream of the initiating Met .", + "entities": [] + }, + { + "id": "9775", + "type": "gene", + "text": "Myosin light chain kinase functions downstream of Ras / ERK to promote migration of urokinase - type plasminogen activator - stimulated cells in an integrin - selective manner .", + "entities": [ + "Myosin light chain kinase", + "Ras", + "ERK", + "urokinase - type plasminogen activator", + "integrin" + ] + }, + { + "id": "9776", + "type": "gene", + "text": "Second , the membrane expression of alpha and beta subunits was mimicked by cholesterol and 17 - ketocholesterol , both of which inhibit HMG - CoA reductase .", + "entities": [ + "HMG - CoA reductase" + ] + }, + { + "id": "9777", + "type": "gene", + "text": "Transcriptional control signals of a herpes simplex virus type 1 late ( gamma 2 ) gene lie within bases - 34 to + 124 relative to the 5 ' terminus of the mRNA .", + "entities": [ + "herpes simplex virus type 1 late ( gamma 2 ) gene" + ] + }, + { + "id": "9778", + "type": "gene", + "text": "Deletion analysis showed that the - 321 / + 41 sequence was sufficient for both the constitutive promoter activity and auto - activation and electrophoretic mobility shift assays identified the interaction of C / EBPs and Sp1 to this region .", + "entities": [ + "C / EBPs", + "Sp1" + ] + }, + { + "id": "9779", + "type": "gene", + "text": "Regulation of ASN1 and ASN2 expression was studied using lacZ fusions and both genes were found to be several times less expressed in the absence of the transcription activator Gcn4p .", + "entities": [ + "ASN1", + "ASN2", + "lacZ fusions", + "Gcn4p" + ] + }, + { + "id": "9780", + "type": "gene", + "text": "Hand - held , continuous - wave Doppler probes , coupled with sound spectral analysis , can successfully predict carotid artery stenosis .", + "entities": [] + }, + { + "id": "9781", + "type": "gene", + "text": "The complete gene organization was obtained by combining the results of the sequence of these clones and those of the characterization of polymerase chain reaction - amplified genomic segments .", + "entities": [] + }, + { + "id": "9782", + "type": "gene", + "text": "The position of the analyst as expert : yesterday and today .", + "entities": [] + }, + { + "id": "9783", + "type": "gene", + "text": "The encoded amino acid sequences in the full - length bovine and porcine cDNAs were identical , consisting of 209 amino acid residues , and were nearly the same as the published sequence determined by Edman degradation .", + "entities": [] + }, + { + "id": "9784", + "type": "gene", + "text": "In 3Y1 and 3Y1 v - crk - transformed fibroblasts , almost all of the total PTP1B and about 40 % of total p130 ( Cas ) co - sediment with membranes composed primarily of endoplasmic reticulum .", + "entities": [ + "v - crk", + "PTP1B", + "p130", + "Cas" + ] + }, + { + "id": "9785", + "type": "gene", + "text": "Green fluorescent protein - tagged UNC - 49B and UNC - 49C subunits are coexpressed in muscle cells and are colocalized to synaptic regions .", + "entities": [ + "UNC - 49B", + "UNC - 49C subunits" + ] + }, + { + "id": "9786", + "type": "gene", + "text": "Treatment of hypertension with a combination of the adrenergic beta receptor blockader , obsidan , and the vasodilator , apressin", + "entities": [ + "adrenergic beta receptor" + ] + }, + { + "id": "9787", + "type": "gene", + "text": "Lower limits ( to 10 micrograms / kg ) were detectable , but with lower reliability ( 60 % ) .", + "entities": [] + }, + { + "id": "9788", + "type": "gene", + "text": "How do graduates of different types of programs perform on state boards ?", + "entities": [] + }, + { + "id": "9789", + "type": "gene", + "text": "In a third experiment , crossover AM between dissimilar textures was investigated , and it was found that the more salient textures carried the AM .", + "entities": [] + }, + { + "id": "9790", + "type": "gene", + "text": "The hypBFCDE operon from Rhizobium leguminosarum biovar viciae is expressed from an Fnr - type promoter that escapes mutagenesis of the fnrN gene .", + "entities": [ + "hypBFCDE operon", + "Fnr - type promoter", + "fnrN gene" + ] + }, + { + "id": "9791", + "type": "gene", + "text": "Experience with xylene - free sections since 1995 at the Vrinnevi Hospital is favorable .", + "entities": [] + }, + { + "id": "9792", + "type": "gene", + "text": "The remaining RAD + cells progressed to form microcolonies ( < 30 cells ) containing aberrantly shaped inviable cells .", + "entities": [ + "RAD +" + ] + }, + { + "id": "9793", + "type": "gene", + "text": "We have previously reported reduced levels of choline acetyltransferase activity in the cerebral cortex of patients who died after a head injury , demonstrating that there is a loss of cortical cholinergic innervation .", + "entities": [ + "choline acetyltransferase" + ] + }, + { + "id": "9794", + "type": "gene", + "text": "CONCLUSION : Rheumatic fever in the Nazareth area is still manifest .", + "entities": [] + }, + { + "id": "9795", + "type": "gene", + "text": "Interferon stimulated gene factor 3 ( ISGF3 ) is a trimeric transcription factor activated on treatment of cells with interferon - alpha and beta ( type I IFNs ) .", + "entities": [ + "Interferon stimulated gene factor 3", + "ISGF3", + "interferon - alpha and beta", + "type I IFNs" + ] + }, + { + "id": "9796", + "type": "gene", + "text": "All were tested for serum ferritin ( SF ) , hemoglobin ( Hb ) level and asked for detailed histories of donations and iron supplementation .", + "entities": [ + "ferritin", + "SF", + "hemoglobin", + "Hb" + ] + }, + { + "id": "9797", + "type": "gene", + "text": "DNase I footprinting and electrophoretic mobility shift analyses revealed two hepatocyte nuclear factor - 1 ( HNF1 ) , three CCAAT / enhancer - binding protein ( C / EBP ) , and one consensus palindromic thyroid hormone response elements within the first 215 base pairs ( bp ) of the promoter sequence of rat Std .", + "entities": [ + "DNase I", + "hepatocyte nuclear factor - 1", + "HNF1", + "CCAAT / enhancer - binding protein", + "C / EBP", + "rat Std" + ] + }, + { + "id": "9798", + "type": "gene", + "text": "Influence of cigarette smoking on some blood coagulation tests .", + "entities": [] + }, + { + "id": "9799", + "type": "gene", + "text": "Synthetic oligonucleotides representing the 19 bp repeat unit strongly reduced the activity of the IE1 / 2 enhancer / promoter in cotransfection assays after transient expression .", + "entities": [ + "IE1 / 2 enhancer / promoter" + ] + }, + { + "id": "9800", + "type": "gene", + "text": "The femoroarterial coronary sinus difference in lactate turned negative , and pH , PCO2 and potassium differences increased in group 2 during pacing .", + "entities": [] + }, + { + "id": "9801", + "type": "gene", + "text": "The pathogenesis of Limited Joint Mobility ( LJM ) in diabetes is unknown , but the abnormality is said to be associated with an increased incidence of microangiopathy .", + "entities": [] + }, + { + "id": "9802", + "type": "gene", + "text": "Moreover , when added to the osteoclast cultures , mrIhh - N markedly stimulated the formation of resorption pits on dentine slices .", + "entities": [ + "mrIhh - N" + ] + }, + { + "id": "9803", + "type": "gene", + "text": "Cytosolic extracts from a variety of mammalian cell lines ( monkey Cos7 , several mouse fibrosarcomas and human HeLa S3 ) demonstrated similar TGF - beta 1 dependent RNA - protein band shifts as cell extract from BALB / c 3T3 mouse fibroblasts .", + "entities": [ + "TGF - beta 1" + ] + }, + { + "id": "9804", + "type": "gene", + "text": "The protein is composed of two major domains separated by a hydrophobic linker region of 20 amino acid residues .", + "entities": [] + }, + { + "id": "9805", + "type": "gene", + "text": "Finally , nonphotosynthetic mutants , including the tscA - lacking photosystem I mutant , H13 , did not show evidence of light - stimulated RNA processing .", + "entities": [ + "tscA - lacking photosystem I mutant" + ] + }, + { + "id": "9806", + "type": "gene", + "text": "The gene encoding human tissue - type plasminogen activator ( t - PA ) is regulated in a cell - type - specific manner .", + "entities": [ + "gene encoding human tissue - type plasminogen activator", + "t - PA" + ] + }, + { + "id": "9807", + "type": "gene", + "text": "Blood pressure also was increased by lidocaine ( 6 mg kg - 1 ) .", + "entities": [] + }, + { + "id": "9808", + "type": "gene", + "text": "Thus , the bovine PEDF cDNA isolated here codes for a functional soluble secreted PEDF glycoprotein .", + "entities": [ + "bovine PEDF cDNA", + "secreted PEDF glycoprotein" + ] + }, + { + "id": "9809", + "type": "gene", + "text": "The mature AP - 2 mRNA is spliced from 7 exons distributed over a region of 18 kb genomic DNA .", + "entities": [ + "AP - 2 mRNA" + ] + }, + { + "id": "9810", + "type": "gene", + "text": "These studies show that UCRBP binds to various target motifs that are distinct from the UCR motif : the adeno - associated virus P5 promoter and elements in the immunoglobulin light - and heavy - chain genes , as well as elements in ribosomal protein genes .", + "entities": [ + "UCRBP", + "adeno - associated virus P5 promoter", + "immunoglobulin light - and heavy - chain", + "ribosomal protein genes" + ] + }, + { + "id": "9811", + "type": "gene", + "text": "However , little was understood about the normal function of CREB - 2 in mammalian development or organ physiology .", + "entities": [ + "CREB - 2" + ] + }, + { + "id": "9812", + "type": "gene", + "text": "Thus , depending on their location , psoralen cross - links affected different steps in the initiation process .", + "entities": [] + }, + { + "id": "9813", + "type": "gene", + "text": "As it had been previously reported that the 18 - bp palindrome contains sufficient nucleotide sequence information for E1 binding , we speculate that a minimal E1 recognition motif is presented in each half site .", + "entities": [ + "E1", + "E1" + ] + }, + { + "id": "9814", + "type": "gene", + "text": "This is predicted to encode a 315 - residue protein containing seven hydrophobic helical regions and a 17 amino acid motif characteristic of the R7G family of G - protein coupled membrane - bound receptors .", + "entities": [ + "R7G family", + "G - protein coupled membrane - bound receptors" + ] + }, + { + "id": "9815", + "type": "gene", + "text": "The second primary mutant contained a proline - to - leucine change at position 243 ( P243L ) .", + "entities": [] + }, + { + "id": "9816", + "type": "gene", + "text": "The genomic fragments were fused upstream of the luciferase reporter gene .", + "entities": [ + "luciferase reporter gene" + ] + }, + { + "id": "9817", + "type": "gene", + "text": "The mean jitter and the fiber density did not change significantly from day 0 ( 30 . 1 + / - 3 . 6 microseconds ; 1 . 4 + / - 0 . 07 ) to day 30 ( 34 . 5 + / - 2 . 7 microseconds ; 1 . 6 + / - 0 . 13 ) .", + "entities": [] + }, + { + "id": "9818", + "type": "gene", + "text": "In this report we describe for the first time the complete primary structure of type X collagen , based on cloning and sequencing of cDNA and genomic DNA .", + "entities": [ + "type X collagen" + ] + }, + { + "id": "9819", + "type": "gene", + "text": "Patients with antibody peaks , defined as fivefold or higher increase in antibody titer compared to the lowest antibody titer over the course of GBS , had higher disability scores during the first two weeks of GBS and a worse clinical outcome ( anti - GM1 IgG and anti - GD1a IgM antibody peaks ) and axonal damage ( anti - GD1a IgM antibody peaks ) , compared to patients without peak antibody titers .", + "entities": [ + "anti - GM1 IgG", + "anti - GD1a IgM antibody", + "anti - GD1a IgM antibody" + ] + }, + { + "id": "9820", + "type": "gene", + "text": "Airway pressure and air flow were measured at the endotracheal tube in 13 children on a variety of ventilators .", + "entities": [] + }, + { + "id": "9821", + "type": "gene", + "text": "A potential outcome of these biochemical effects may include the limited responsiveness of infected T cells to antigenic stimulation observed during HIV - 1 infection .", + "entities": [] + }, + { + "id": "9822", + "type": "gene", + "text": "Results of two - hybrid assays and electrophoretic mobility shift assays strongly suggest that all HD - Zip proteins of families I and II can form homodimers and also heterodimers with all HD - Zip proteins of the same family .", + "entities": [ + "HD - Zip proteins", + "HD - Zip proteins" + ] + }, + { + "id": "9823", + "type": "gene", + "text": "When the blood pressure increase in response to smoking was blunted by nitroprusside infusion , there was a striking increase in muscle SNA .", + "entities": [] + }, + { + "id": "9824", + "type": "gene", + "text": "Vascular endothelial growth factor ( VEGF ) , a potent agonist secreted by virtually all cells , controls migration and division of vascular endothelial cells .", + "entities": [ + "Vascular endothelial growth factor", + "VEGF" + ] + }, + { + "id": "9825", + "type": "gene", + "text": "A second peptide ( amino acids 58 - 77 ) also antagonized p21 - activity , but this peptide did not affect the ability of p21 to interact with cyclin E / Cdk2 .", + "entities": [ + "p21", + "p21", + "cyclin E", + "Cdk2" + ] + }, + { + "id": "9826", + "type": "gene", + "text": "RESULTS : During the stabilization period , PaCO2 ( mean + / - SD ) was 33 + / - 5 mm Hg , and arrhythmias were not detected .", + "entities": [] + }, + { + "id": "9827", + "type": "gene", + "text": "Three cDNAs encoding basic leucine zipper ( bZIP ) - type ABRE - binding proteins were isolated by using the yeast one - hybrid system and were designated AREB1 , AREB2 , and AREB3 ( ABA - responsive element binding protein ) .", + "entities": [ + "basic leucine zipper ( bZIP ) - type ABRE - binding proteins", + "AREB1", + "AREB2", + "AREB3", + "ABA - responsive element binding protein" + ] + }, + { + "id": "9828", + "type": "gene", + "text": "This study reports the effects of a preparation with 50 micrograms ethinyl estradiol and 2 mg cyproterone acetate on gonadotropins , prolactin , testosterone , sex hormone binding globulin ( SHBG ) , androstenedione , and calculated free testosterone index before and after six months of treatment .", + "entities": [ + "gonadotropins", + "prolactin", + "sex hormone binding globulin", + "SHBG" + ] + }, + { + "id": "9829", + "type": "gene", + "text": "Current status of zinc deficiency in the pathogenesis of neurological , dermatological and musculoskeletal disorders .", + "entities": [] + }, + { + "id": "9830", + "type": "gene", + "text": "As predicted by the Wing and Kristofferson model , the durations of successive ISIs tended to be negatively correlated .", + "entities": [] + }, + { + "id": "9831", + "type": "gene", + "text": "Common history and prospects in surgical gynecology of the Charite and the Vienna University Clinic", + "entities": [] + }, + { + "id": "9832", + "type": "gene", + "text": "Polypeptide growth factors and cytokines mediate their biochemical functions through their responsive receptors .", + "entities": [] + }, + { + "id": "9833", + "type": "gene", + "text": "No systematic L - R differences were observed .", + "entities": [] + }, + { + "id": "9834", + "type": "gene", + "text": "Ent - kaurene synthase from the fungus Phaeosphaeria sp .", + "entities": [ + "Ent - kaurene synthase from the fungus Phaeosphaeria" + ] + }, + { + "id": "9835", + "type": "gene", + "text": "Dose of 20 ig were administered within a scheme from 0 . 1 to 6 months in order to study its immunogenicity , which was evaluated at 2 , 7 , and 12 months after the first dose .", + "entities": [] + }, + { + "id": "9836", + "type": "gene", + "text": "Six out of ten hearts from macerated stillborn infants showed varying degrees of positive staining .", + "entities": [] + }, + { + "id": "9837", + "type": "gene", + "text": "Transient transfections showed that a single mutation ( 556M ) decreased TBLV enhancer activity at least 20 - fold in two different T - cell lines .", + "entities": [ + "TBLV enhancer" + ] + }, + { + "id": "9838", + "type": "gene", + "text": "In EEG only single slow waves above left temporal region were revealed .", + "entities": [] + }, + { + "id": "9839", + "type": "gene", + "text": "Changes induced in the gills of milkfish ( Chanos chanos Forsskal ) fingerlings after acute exposure to nifurpirinol ( Furanace ; P - 7138 ) .", + "entities": [] + }, + { + "id": "9840", + "type": "gene", + "text": "Gag protein sequence motifs of the NC domain of primate foamy viruses assumed to be involved in genome encapsidation are not conserved in FeFV .", + "entities": [ + "Gag", + "NC domain" + ] + }, + { + "id": "9841", + "type": "gene", + "text": "3 ) and one distal ( - 11 . 8 / - 10 . 9 ) , presented an enhancer activity in pituitary cells when placed upstream of the SV40 promoter .", + "entities": [ + "SV40 promoter" + ] + }, + { + "id": "9842", + "type": "gene", + "text": "REM dream content was scored for categories suggesting the predominant influence of the left hemisphere , e . g . , good ego functioning , verbalization , or the right hemisphere , e . g . , music , spatial salience , bizarreness .", + "entities": [] + }, + { + "id": "9843", + "type": "gene", + "text": "The same IL - 4 - inducible reporter gene is also synergistically activated by the endogenous Stat6 and NF - kappaB proteins in IL - 4 - stimulated I . 29mu B lymphoma cells .", + "entities": [ + "IL - 4", + "endogenous Stat6", + "NF - kappaB proteins", + "IL - 4" + ] + }, + { + "id": "9844", + "type": "gene", + "text": "The role of daunorubicin in induction therapy for adult acute myeloid leukemia", + "entities": [] + }, + { + "id": "9845", + "type": "gene", + "text": "Enantiomer separation of venlafaxine and O - desmethylvenlafaxine in human plasma .", + "entities": [] + }, + { + "id": "9846", + "type": "gene", + "text": "Closeup : a resource for nurses who smoke .", + "entities": [] + }, + { + "id": "9847", + "type": "gene", + "text": "The results of our ten - fold cross - validation experiments show that , on the average , the system increases the specificity from 0 . 19 ( 0 . 35 ) to 0 . 69 ( 0 . 74 ) at a sensitivity level of 1 . 0 ( 0 . 95 ) .", + "entities": [] + }, + { + "id": "9848", + "type": "gene", + "text": "Selected topics in laboratory animal medicine .", + "entities": [] + }, + { + "id": "9849", + "type": "gene", + "text": "Study of bacterial motility and rate of movement using a closed circuit television", + "entities": [] + }, + { + "id": "9850", + "type": "gene", + "text": "The statistical significance of the prognosis factors was studied by uni - and multivariative methods , according to the model of Cox , with the help of an IMB computer .", + "entities": [] + }, + { + "id": "9851", + "type": "gene", + "text": "Spore inocula ( approximately 10 ( 6 ) / coupon ) were dried onto 0 . 5 - in .", + "entities": [] + }, + { + "id": "9852", + "type": "gene", + "text": "GlcNAc - and GlcNAc2 - PP - Dolichol biosynthesis could be shown with isolated S . cerevisiae membranes from cells harboring the recombinant plasmid and grown on glucose thus suppressing transcription of the endogenous gene .", + "entities": [] + }, + { + "id": "9853", + "type": "gene", + "text": "These analyses re - open the question whether all the CesA genes encode cellulose synthases or whether some of the sub - class members may encode other non - cellulosic ( 1 - - > 4 ) beta - glycan synthases in plants .", + "entities": [ + "CesA genes", + "cellulose synthases", + "non - cellulosic ( 1 - - > 4 ) beta - glycan synthases" + ] + }, + { + "id": "9854", + "type": "gene", + "text": "In a second patient the VT became nonsustained .", + "entities": [] + }, + { + "id": "9855", + "type": "gene", + "text": "A pharmacokinetic study of apalcillin was performed in 12 patients in an intensive - care unit .", + "entities": [] + }, + { + "id": "9856", + "type": "gene", + "text": "These articles both report the results of multi - institutional , randomized , phase 3 trials for the treatment of patients with localized ( T1 - 3 N0 - 1 M0 ) esophageal squamous cell carcinoma ( SCC ) or esophageal adenocarcinoma .", + "entities": [] + }, + { + "id": "9857", + "type": "gene", + "text": "In contrast to previously characterized proteophosphoglycans , the ppg1 gene product is predominantly membrane - associated and it is expressed on the promastigote cell surface .", + "entities": [ + "ppg1" + ] + }, + { + "id": "9858", + "type": "gene", + "text": "These results indicate that Rb protein is interacting with some component ( s ) of the cell cycle - regulatory machinery during G2 phase .", + "entities": [ + "Rb protein" + ] + }, + { + "id": "9859", + "type": "gene", + "text": "Effect of tracheal insufflation of deferoxamine on acute ozone toxicity in rats .", + "entities": [] + }, + { + "id": "9860", + "type": "gene", + "text": "Fundamental and clinical evaluation of equilibrium dialysis - - radioimmunoassay system for measurement of serum free thyroxine", + "entities": [] + }, + { + "id": "9861", + "type": "gene", + "text": "The cycle length of induced VT ( n = 10 VTs ) was 380 + / - 41 msec .", + "entities": [] + }, + { + "id": "9862", + "type": "gene", + "text": "Our data show also that phagocytic killing of meningococci is probably a more consistent assay than antibody titer levels for antimeningococcal immunity , especially in LCC - deficient patients .", + "entities": [] + }, + { + "id": "9863", + "type": "gene", + "text": "Female patients with breast cancer diagnosed between 1982 and 1991 at Roswell Park Cancer Institute ( RPCI ) in Buffalo , New York , who provided information on their cigarette smoking history at the time of their diagnosis were included .", + "entities": [] + }, + { + "id": "9864", + "type": "gene", + "text": "An association was demonstrated between the expression of aberrantly and / or alternatively spliced mdm2 mRNAs and a lack of progesterone receptor .", + "entities": [ + "mdm2 mRNAs", + "progesterone receptor" + ] + }, + { + "id": "9865", + "type": "gene", + "text": "A full - length PRL receptor ( PRLR ) complementary DNA from pigeons was obtained by screening pigeon crop sac libraries and by reverse transcription coupled with polymerase chain reaction .", + "entities": [ + "full - length PRL receptor", + "PRLR" + ] + }, + { + "id": "9866", + "type": "gene", + "text": "Ficat and Bizou ' s condylar depth index and the condylar - joint surface angle of Brattstrom are recommended as especially suitable methods of measurement .", + "entities": [] + }, + { + "id": "9867", + "type": "gene", + "text": "We suggest that ventriculopleural shunting should be considered as the preferred alternative to peritoneal drainage in children with intra - abdominal adhesions or with a history of recent peritoneal infection .", + "entities": [] + }, + { + "id": "9868", + "type": "gene", + "text": "Significance of the pulmonary gas exchange reaction to physical loading in evaluating the effectiveness of mitral commissurotomy", + "entities": [] + }, + { + "id": "9869", + "type": "gene", + "text": "Polymerization of neurofilament L protein in vitro was inhibited by phosphorylation of neurofilament L protein by PKN .", + "entities": [ + "neurofilament L protein", + "neurofilament L protein", + "PKN" + ] + }, + { + "id": "9870", + "type": "gene", + "text": "Magnetotherapy of hepatitis A and B in children", + "entities": [] + }, + { + "id": "9871", + "type": "gene", + "text": "In Wnt signaling , beta - catenin and plakoglobin transduce signals to the nucleus through interactions with TCF - type transcription factors .", + "entities": [ + "Wnt", + "beta - catenin", + "plakoglobin", + "TCF - type transcription factors" + ] + }, + { + "id": "9872", + "type": "gene", + "text": "These rearrangements result in the formation of chimeric genes showing the tyrosine kinase domain of ret fused with the 5 ' end sequences of different genes .", + "entities": [ + "tyrosine kinase domain", + "ret" + ] + }, + { + "id": "9873", + "type": "gene", + "text": "One extract with the lowest PCA content was non - carcinogenic .", + "entities": [] + }, + { + "id": "9874", + "type": "gene", + "text": "RPA190 encodes a polypeptide chain of 186 , 270 daltons in a large uninterrupted reading frame .", + "entities": [ + "RPA190" + ] + }, + { + "id": "9875", + "type": "gene", + "text": "In contrast , no change was detected in the phenotype of ' unstressed ' clones , with respect to any of the following parameters : proliferation rate in monolayer , serum - dependence for proliferation or survival , tumorigenicity , cellular morphology , or tissue - specific differentiation markers .", + "entities": [] + }, + { + "id": "9876", + "type": "gene", + "text": "Hydrallazine also caused a slight increase in plasma renin activity and urinary excretion of noradrenaline .", + "entities": [ + "plasma renin" + ] + }, + { + "id": "9877", + "type": "gene", + "text": "CXC chemokines bind to unique sets of selectivity determinants that can function independently and are broadly distributed on multiple domains of human interleukin - 8 receptor B .", + "entities": [ + "interleukin - 8 receptor B" + ] + }, + { + "id": "9878", + "type": "gene", + "text": "Progression after first - line chemotherapy was associated with significantly worse survival for patients with metastasis .", + "entities": [] + }, + { + "id": "9879", + "type": "gene", + "text": "To test the hypothesis that progestin - mediated increases in resting core temperature and the core temperature threshold for sweating onset are counteracted by estrogen , we studied eight women ( 24 + / - 2 yr ) at 27 degrees C rest , during 20 min of passive heating ( 35 degrees C ) , and during 40 min of exercise at 35 degrees C .", + "entities": [] + }, + { + "id": "9880", + "type": "gene", + "text": "The other hypoglycaemic patient showed an exaggerated insulin release in response to tolbutamide .", + "entities": [ + "insulin" + ] + }, + { + "id": "9881", + "type": "gene", + "text": "For replication reporter constructs where E1 and E2 are supplied in trans by the respective expression vectors , distance between the half sites seems to play a major role , yet the phasing relationships are measurable .", + "entities": [ + "E1", + "E2" + ] + }, + { + "id": "9882", + "type": "gene", + "text": "Diclofenac sodium - chlormezanone poisoning .", + "entities": [] + }, + { + "id": "9883", + "type": "gene", + "text": "Troubled CareNetwork gets pact from largest teacher union in Wis .", + "entities": [] + }, + { + "id": "9884", + "type": "gene", + "text": "TNF - alpha exposure markedly increased activity of several RNA - binding proteins , especially a novel Mr 50 , 000 - 55 , 000 RNA - binding protein .", + "entities": [ + "TNF - alpha" + ] + }, + { + "id": "9885", + "type": "gene", + "text": "A case observed in Saigon", + "entities": [] + }, + { + "id": "9886", + "type": "gene", + "text": "Cut - off levels that define abnormality are rather arbitrary and this decreases the specificity of the test in apparently healthy patients .", + "entities": [] + }, + { + "id": "9887", + "type": "gene", + "text": "Endocardial fibro - elastosis , mitral incompetence , and coarctation of abdominal aorta .", + "entities": [] + }, + { + "id": "9888", + "type": "gene", + "text": "These results suggest that less antidopaminergic activity of RHAL in this neuroleptic test might be explained by the lesser conversion of RHAL to HAL .", + "entities": [] + }, + { + "id": "9889", + "type": "gene", + "text": "Ime1 plays a pivotal role in the initiation of meiosis in a / alpha diploid cells of Saccharomyces cerevisiae .", + "entities": [ + "Ime1" + ] + }, + { + "id": "9890", + "type": "gene", + "text": "The COD and color removals were both more than 90 % when FeCl3 was used as the coagulation ( dosages of two - step coagulation were 0 . 031 and 0 . 012 mol / L respectively ) after a ferrous hydrogen peroxide oxidation pretreatment at a H2O2 dosage of 0 . 06 mol / L .", + "entities": [] + }, + { + "id": "9891", + "type": "gene", + "text": "EBER1 mRNA , a consistent marker of viral latency , was positive in all PEL cases , although at lower levels than in the non - PEL controls due to EBER1 expression by only a variable subset of lymphoma cells .", + "entities": [ + "EBER1 mRNA", + "EBER1" + ] + }, + { + "id": "9892", + "type": "gene", + "text": "Receptor protein tyrosine phosphatases ( RPTPs ) comprise a family of proteins that feature intracellular phosphatase domains and an ectodomain with putative ligand - binding motifs .", + "entities": [ + "Receptor protein tyrosine phosphatases", + "RPTPs" + ] + }, + { + "id": "9893", + "type": "gene", + "text": "The rate of resectability is low and 5 - year survival is very poor .", + "entities": [] + }, + { + "id": "9894", + "type": "gene", + "text": "Tyrosine kinase oncogenes abrogate interleukin - 3 dependence of murine myeloid cells through signaling pathways involving c - myc : conditional regulation of c - myc transcription by temperature - sensitive v - abl .", + "entities": [ + "Tyrosine kinase", + "interleukin - 3", + "c - myc", + "c - myc", + "v - abl" + ] + }, + { + "id": "9895", + "type": "gene", + "text": "Effect of indomethacin on coronary circulation : effect on ECG tracing", + "entities": [] + }, + { + "id": "9896", + "type": "gene", + "text": "In the Oct - 1 crystal , the POU - specific domain recognizes a GCAT half - site , while the corresponding sequence recognized by the Pit - 1 POU - specific domain , GTAT , is on the opposing strand .", + "entities": [ + "Oct - 1", + "POU - specific domain", + "POU" + ] + }, + { + "id": "9897", + "type": "gene", + "text": "We analyzed serial biopsy specimens from eight patients with FL for secondary alterations of the rearranged bcl - 2 gene in the breakpoint and open reading frame ( ORF ) regions .", + "entities": [ + "rearranged bcl - 2 gene" + ] + }, + { + "id": "9898", + "type": "gene", + "text": "Practical use and interpretation of viral hepatitis B markers and hepatic biopsy in HBs Ag carriers and at the chronic hepatitis stage", + "entities": [ + "HBs Ag" + ] + }, + { + "id": "9899", + "type": "gene", + "text": "Distal lower motor neuron syndrome with high - titer serum IgM anti - GM1 antibodies : improvement following immunotherapy with monthly plasma exchange and intravenous cyclophosphamide .", + "entities": [ + "serum IgM anti - GM1 antibodies" + ] + }, + { + "id": "9900", + "type": "gene", + "text": "A cDNA clone was identified encoding a second GHS - R - related gene ( GPR39 ) .", + "entities": [ + "GHS - R - related gene", + "GPR39" + ] + }, + { + "id": "9901", + "type": "gene", + "text": "Procion yellow dye was injected intracellularly into large auditory fibers of goldfish to investigate the relationship between the response type of these fibers and their site of termination in the saccular macula .", + "entities": [] + }, + { + "id": "9902", + "type": "gene", + "text": "The amino acid sequence was determined to be residues 716 - 724 and hence lysine residue 721 is located within the ATP - binding site .", + "entities": [] + }, + { + "id": "9903", + "type": "gene", + "text": "Compound 1 is either 21 - O - angeloyl , 22 - O - tigloyl R1 - barrigenol , or 21 - O - tigloyl , 22 - O - angeloyl R1 - barrigenol .", + "entities": [] + }, + { + "id": "9904", + "type": "gene", + "text": "The associations between sex - hormone - binding globulin capacity ( SHBG ) , age , body mass index ( BMI ) , and physical fitness have been studied in 34 men and 36 women .", + "entities": [ + "sex - hormone - binding globulin", + "SHBG" + ] + }, + { + "id": "9905", + "type": "gene", + "text": "The same response occurs whether acrylamide is given immediately after nerve ligation or 1 week later .", + "entities": [] + }, + { + "id": "9906", + "type": "gene", + "text": "Tissue - specific expression of the tmy - 1 gene was determined by microinjection of a promoter / lacZ fusion gene and with immunohistochemistry by using affinity - purified tissue - specific anti - tropomyosins .", + "entities": [ + "tmy - 1 gene", + "promoter / lacZ fusion gene", + "tissue - specific anti - tropomyosins" + ] + }, + { + "id": "9907", + "type": "gene", + "text": "Mechanical ventilation in control lungs produced a 47 % decrease in chord compliance , an increase in lung lavage levels of tumor necrosis factor ( TNF ) - alpha ( 722 + / - 306 pg / ml ) , interleukin ( IL ) - 1beta ( 902 + / - 322 pg / ml ) , and macrophage inflammatory protein - 2 ( MIP - 2 ) ( 363 + / - 104 pg / ml ) as compared with low levels of cytokines detected in preventilation data , and no change in percentage of surfactant large aggregates ( LA ) .", + "entities": [ + "tumor necrosis factor ( TNF ) - alpha", + "interleukin ( IL ) - 1beta", + "macrophage inflammatory protein - 2", + "MIP - 2" + ] + }, + { + "id": "9908", + "type": "gene", + "text": "Envelope - function matching conditions for GaAs / ( Al , Ga ) As heterojunctions .", + "entities": [] + }, + { + "id": "9909", + "type": "gene", + "text": "Managing HIV .", + "entities": [] + }, + { + "id": "9910", + "type": "gene", + "text": "Letter : Lactose tolerance tests as a predictor of milk tolerance .", + "entities": [] + }, + { + "id": "9911", + "type": "gene", + "text": "Herpes virus infection was characterized by inversion of the T4 / T8 ratio below 1 . 0 ( sensitivity 90 % , specificity 88 % ) , caused by proliferation of the T8 subpopulation , which - - compared with the findings in patients with rejection crises - - was significantly raised ( P less than 0 . 001 ) .", + "entities": [] + }, + { + "id": "9912", + "type": "gene", + "text": "An essential role of c - Jun and c - Fos in basal and PMA - stimulated transcription of the PAI - 1 gene is demonstrated by our finding that antisense c - jun and c - fos oligodeoxynucleotides both strongly reduced basal and PMA - stimulated PAI - 1 synthesis .", + "entities": [ + "c - Jun", + "c - Fos", + "PAI - 1 gene", + "c - jun", + "c - fos", + "PAI - 1" + ] + }, + { + "id": "9913", + "type": "gene", + "text": "Furthermore , binding of recombinant Myb and Ets - 2 protein to these fragments could be competed with an excess of double stranded oligodeoxynucleotides containing canonical , but not mutated , Myb - or Ets - binding sites .", + "entities": [ + "recombinant Myb", + "Ets - 2 protein", + "Myb", + "Ets - binding sites" + ] + }, + { + "id": "9914", + "type": "gene", + "text": "The alcoholic patient , his work and the subjectivity of the period", + "entities": [] + }, + { + "id": "9915", + "type": "gene", + "text": "Protein sequence analysis reveals that MAN1 shares a conserved globular domain of approximately 40 amino acids , which we term the LEM module , with inner nuclear membrane proteins lamina - associated polypeptide 2 and emerin .", + "entities": [ + "MAN1", + "LEM module", + "lamina - associated polypeptide 2", + "emerin" + ] + }, + { + "id": "9916", + "type": "gene", + "text": "No hypotension was noted in patients with toxemia and only 2 ran a fever above 37 . 5 degrees C .", + "entities": [] + }, + { + "id": "9917", + "type": "gene", + "text": "PATIENTS AND METHODS : Immediately before radical prostatectomy , bone marrow aspirates from both sides of the iliac crest were taken from 287 patients .", + "entities": [] + }, + { + "id": "9918", + "type": "gene", + "text": "MAIN OUTCOME MEASURES : Percentage change in the apnea - hypopnea index ( AHI ; apnea events + hypopnea events per hour of sleep ) and odds of developing moderate - to - severe SDB ( defined by an AHI > or = 15 events per hour of sleep ) , with respect to change in weight .", + "entities": [] + }, + { + "id": "9919", + "type": "gene", + "text": "Cocaine - treated rats acquired a preference for cocaine - associated contextual stimuli ( CS ) relative to saline - injected control rats .", + "entities": [] + }, + { + "id": "9920", + "type": "gene", + "text": "Strengthening the biological weapons convention and implications on the pharmaceutical and biotechnology industry .", + "entities": [] + }, + { + "id": "9921", + "type": "gene", + "text": "The simultaneous recording of electrical activity from the surface electrocardiogram , right ventricular apex , His bundle , high right atrium , coronary sinus , with or without a roving mapping catheter , enables us to precisely map the electrical activation sequence in the heart .", + "entities": [] + }, + { + "id": "9922", + "type": "gene", + "text": "Cells differentiate in response to various extracellular stimuli .", + "entities": [] + }, + { + "id": "9923", + "type": "gene", + "text": "Influence of neural regulation on anti - arrhythmic effects of GABA in rats", + "entities": [] + }, + { + "id": "9924", + "type": "gene", + "text": "They were randomly allocated to receive either 625 mg of calcium carbonate ( 250 mg of elemental calcium ) at the end of a meal three times a day ( group A , n = 26 ) or calcium carbonate in the same manner plus 0 . 625 mg / day of conjugated equine estrogen and 5 mg medrogestone acetate from day 1 - 12 each month ( group B , n = 30 ) .", + "entities": [] + }, + { + "id": "9925", + "type": "gene", + "text": "For oral administration , AUC0 - infinity was 58 . 47 + / - 16 . 37 microg x h / ml , t1 / 2beta was 18 . 39 + / - 0 . 06 hours , maximum concentration ( Cmax ) was 2 . 12 + / - 00 . 51 microg / ml , time to Cmax was 2 . 20 + / - 2 . 17 hours , mean absorption time was 2 . 09 + / - 0 . 51 hours , and bioavailability was 42 + / - 0 . 42 % .", + "entities": [] + }, + { + "id": "9926", + "type": "gene", + "text": "The mei4 + gene of the fission yeast Schizosaccharomyces pombe was cloned by functional complementation .", + "entities": [ + "mei4 + gene" + ] + }, + { + "id": "9927", + "type": "gene", + "text": "The approach derives from a recently described strategy for making recombinants from five overlapping EBV cosmid - cloned DNAs ( B .", + "entities": [] + }, + { + "id": "9928", + "type": "gene", + "text": "A TATA - less promoter containing binding sites for ubiquitous transcription factors mediates cell type - specific regulation of the gene for transcription enhancer factor - 1 ( TEF - 1 ) .", + "entities": [ + "transcription enhancer factor - 1", + "TEF - 1" + ] + }, + { + "id": "9929", + "type": "gene", + "text": "Recent studies have suggested that SHP - 1 regulates the function of Jak family tyrosine kinases , as shown by its constitutive association with the Tyk2 kinase and the hyperphosphorylation of Jak kinases in the motheaten cells that lack functional SHP - 1 .", + "entities": [ + "SHP - 1", + "Jak", + "tyrosine kinases", + "Tyk2 kinase", + "Jak kinases", + "SHP - 1" + ] + }, + { + "id": "9930", + "type": "gene", + "text": "Subsets of patients were performed according to the severity of trauma ( ISS < 9 ; 9 - 17 ; 18 - 31 ; > 32 ) , based on the different injury pattern , and survivors versus nonsurvivors as well .", + "entities": [] + }, + { + "id": "9931", + "type": "gene", + "text": "Detailed analysis of alpha1 , 3GT transcripts revealed two major alternative splicing patterns in the 5 ' - untranslated region ( 5 ' - UTR ) and evidence for minor splicing activity that occurs in a tissue - specific manner .", + "entities": [ + "alpha1 , 3GT transcripts" + ] + }, + { + "id": "9932", + "type": "gene", + "text": "Synaptic targeting of the postsynaptic density protein PSD - 95 mediated by a tyrosine - based trafficking signal .", + "entities": [ + "postsynaptic density protein PSD - 95" + ] + }, + { + "id": "9933", + "type": "gene", + "text": "Primary amenorrhoea in a phenotypically female individual with a karyotype 46 , xy and bilateral gonadoblastoma", + "entities": [] + }, + { + "id": "9934", + "type": "gene", + "text": "Dissociation and complexation of the fluoroquinolone antimicrobials - - an update .", + "entities": [] + }, + { + "id": "9935", + "type": "gene", + "text": "Its clinical and histopathologic characteristics .", + "entities": [] + }, + { + "id": "9936", + "type": "gene", + "text": "Cloning , sequencing and expression of the 3 - phosphoglycerate kinase gene of Pyrococcus woesei in Escherichia coli and characterization of the protein .", + "entities": [ + "3 - phosphoglycerate kinase gene" + ] + }, + { + "id": "9937", + "type": "gene", + "text": "J .", + "entities": [] + }, + { + "id": "9938", + "type": "gene", + "text": "The Harleco apparatus is a simple , useful , cost - effective adjunct to the diagnosis and treatment of this life - threatening condition .", + "entities": [] + }, + { + "id": "9939", + "type": "gene", + "text": "Schizosaccharomyces pombe cells respond to nutrient deprivation by altering G2 / M cell size control .", + "entities": [] + }, + { + "id": "9940", + "type": "gene", + "text": "Comparative DNA sequence analysis showed the Genethon microsatellite D19S596 lies 2 . 2 kb downstream of the coding region of FUT1 , indicating that the cluster comprising the closely linked FUT1 and FUT2 genes is located 4 cM distal to D19S412 ( lod score 13 . 7 ) and 9 cM proximal to D19S571 ( lod score 11 . 7 ) .", + "entities": [ + "microsatellite D19S596", + "FUT1", + "FUT1", + "FUT2 genes", + "D19S412", + "D19S571" + ] + }, + { + "id": "9941", + "type": "gene", + "text": "These results are the first to demonstrate the structural organization of a vertebrate gene encoding an integral membrane protein of the nuclear envelope that may be a member of a family of polypeptides conserved in evolution .", + "entities": [] + }, + { + "id": "9942", + "type": "gene", + "text": "Administration of dexamethasone was associated with progressive rises in plasma 17 alpha OH progesterone , 11 beta - desoxycortisol , DHEA sulphate , androstenedione and testosterone , together with increased urinary excretion of androsterone , 11 beta OH androsterone , etiocholanolone , DHEA , and 16 alpha OH DHEA .", + "entities": [] + }, + { + "id": "9943", + "type": "gene", + "text": "The ultrastructure of retinal vessels was examined in three eyes from diabetic patients and two eyes from control subjects .", + "entities": [] + }, + { + "id": "9944", + "type": "gene", + "text": "Oxidative degradation of adrenaline solutions : study of the intermediate stages and their analytic value for the control of this solute", + "entities": [] + }, + { + "id": "9945", + "type": "gene", + "text": "A significant direct relationship was observed between the percent area density of smooth muscle and the percent change in peak urinary flow rate .", + "entities": [] + }, + { + "id": "9946", + "type": "gene", + "text": "In Exp .", + "entities": [] + }, + { + "id": "9947", + "type": "gene", + "text": "To facilitate manipulation of large genomic sequences , we developed a method of converting Escherichia coli P1 artificial chromosomes ( PACs ) into yeast artificial chromosomes ( YACs ) .", + "entities": [] + }, + { + "id": "9948", + "type": "gene", + "text": "In angiodysplasia , ectatic vessels in the mucosa appeared to contain less collagen type IV than similarly sized vessels in the submucosa , and perforating vessels appeared in many cases to lose staining at the level of the muscularis mucosae .", + "entities": [ + "collagen type IV" + ] + }, + { + "id": "9949", + "type": "gene", + "text": "Marked hemolysis significantly increased plasma values of potassium , phosphorus , total protein , and aspartate aminotransferase .", + "entities": [ + "aspartate aminotransferase" + ] + }, + { + "id": "9950", + "type": "gene", + "text": "This coat protein consists of Sar1p , the Sec23p protein complex containing Sec23p and Sec24p , and the Sec13p protein complex containing Sec13p and a novel 150 - kDa protein , p150 .", + "entities": [ + "coat protein", + "Sar1p", + "Sec23p protein complex", + "Sec23p", + "Sec24p", + "Sec13p protein complex", + "Sec13p", + "150 - kDa protein , p150" + ] + }, + { + "id": "9951", + "type": "gene", + "text": "Examination of ANCA is not only a significant contribution towards a more accurate diagnosis of renal vasculitis , but also an indicator of the activity of the disease and thus of the effectiveness of immunosuppressive treatment .", + "entities": [ + "ANCA" + ] + }, + { + "id": "9952", + "type": "gene", + "text": "Linearized overall infection rates ( events / 100 patient - days ) were 2 . 05 + / - 0 . 33 ( heart - lung ) and 2 . 34 + / - 0 . 34 ( double - lung ; P = NS ) at 3 months .", + "entities": [] + }, + { + "id": "9953", + "type": "gene", + "text": "According to symptoms , signs , imaging features , operation findings , the original places and the expansive directions of the tumor , they were divided into four clinical types : sellar , clival , occipito - temporal and extent .", + "entities": [] + }, + { + "id": "9954", + "type": "gene", + "text": "Schooling is found to be related to good health even after controlling for differences in observable health inputs .", + "entities": [] + }, + { + "id": "9955", + "type": "gene", + "text": "Statistical analysis of the degrees of secondary spinal cord compression was performed in group - 1 dogs by measuring and comparing ratios of the vertical to the horizontal diameters of the transverse spinal cord sections from locations within ( T12 to L1 ) and out of ( T11 , T11 - 12 , L1 - 2 , and L2 ) the region of surgical intervention .", + "entities": [] + }, + { + "id": "9956", + "type": "gene", + "text": "Inhibition of the Raf - 1 target ERK kinase ( MEK ) either attenuated or abolished Rp - cAMPS - and PKI - induced ERK activation , caldesmon phosphorylation , and stress fiber formation .", + "entities": [ + "ERK kinase", + "MEK", + "PKI", + "ERK", + "caldesmon" + ] + }, + { + "id": "9957", + "type": "gene", + "text": "Vitamin D3 plus nicotine treatment produced parallel increases in cardiac mass and elastic modulus , with a significant correlation between the two .", + "entities": [] + }, + { + "id": "9958", + "type": "gene", + "text": "Genomic organization of the human phosphodiesterase PDE11A gene .", + "entities": [ + "phosphodiesterase PDE11A gene" + ] + }, + { + "id": "9959", + "type": "gene", + "text": "This paper reports the results of a laboratory study on aldicarb and its main metabolites , aldicarb sulfone and aldicarb sulfoxide .", + "entities": [] + }, + { + "id": "9960", + "type": "gene", + "text": "Together , these results identify HPK1 as a new component of TCR signaling .", + "entities": [ + "HPK1", + "TCR" + ] + }, + { + "id": "9961", + "type": "gene", + "text": "Thus , Hex expression marks the earliest unequivocal molecular anteroposterior asymmetry in the mouse embryo and indicates that the anteroposterior axis of the embryo develops from conversion of a proximodistal asymmetry established in the primitive endoderm lineage .", + "entities": [ + "Hex" + ] + }, + { + "id": "9962", + "type": "gene", + "text": "The system consisted of the intact canine heart connected to a microcomputer that operated as the modulated parasystolic pacemaker .", + "entities": [] + }, + { + "id": "9963", + "type": "gene", + "text": "Six ( four FAP ; two primary amyloidosis ) also had diffusely positive myocardial uptakes , but the intensity was less than that of the sternum .", + "entities": [] + }, + { + "id": "9964", + "type": "gene", + "text": "In Experiments 1 and 2 , infants , like adults , initially categorized novel objects on the basis of physical appearance , but only if trained with multiple exemplars , after delays of 1 and 7 days .", + "entities": [] + }, + { + "id": "9965", + "type": "gene", + "text": "The patient with a prolonged fever caused by dissecting aneurysm of the aorta in whom pleuropneumonia masked the real diseases has been presented .", + "entities": [] + }, + { + "id": "9966", + "type": "gene", + "text": "Within the compartment or dimension of severity of depression a subscale of the Hamilton Depression Scale ( or the Melancholia Scale ) was shown to have reached an instrumental perfection , e . g . as an outcome measure of antidepressant treatment .", + "entities": [] + }, + { + "id": "9967", + "type": "gene", + "text": "A low aspirin esterase activity may be a contributory factor in precipitating these aspirin sensitive reactions .", + "entities": [ + "aspirin esterase" + ] + }, + { + "id": "9968", + "type": "gene", + "text": "STK / RON - expressing Ba / F3 pro - B cells ( BaF / STK ) exhibited MSP - dependent growth , whereas STK / RON - expressing mouse erythroleukaemia cells ( MEL / STK ) displayed MSP - induced apoptosis .", + "entities": [ + "STK", + "RON", + "STK", + "MSP", + "STK", + "RON", + "STK", + "MSP" + ] + }, + { + "id": "9969", + "type": "gene", + "text": "Williams , 2 August 1977 .", + "entities": [] + }, + { + "id": "9970", + "type": "gene", + "text": "Effect of single base substitutions at glycine - 870 codon of gramicidin S synthetase 2 gene on proline activation .", + "entities": [ + "gramicidin S synthetase 2 gene" + ] + }, + { + "id": "9971", + "type": "gene", + "text": "METHODS : Ten influenza A ( H3N2 ) viruses isolated during the outbreaks were examined for resistance to amantadine and rimantadine by means of an enzyme immunoassay and by sequencing of the viral nucleic acid that encodes the transmembrane domain of the M2 protein .", + "entities": [ + "M2 protein" + ] + }, + { + "id": "9972", + "type": "gene", + "text": "Identification of an immediate - early gene in the Marek ' s disease virus long internal repeat region which encodes a unique 14 - kilodalton polypeptide .", + "entities": [ + "immediate - early gene" + ] + }, + { + "id": "9973", + "type": "gene", + "text": "Whereas both MAP and MSNA increase during SHG , the transition from SHG to PHI is characterized by a transient reduction in MAP but sustained elevation in MSNA , facilitating separation of these factors in vivo .", + "entities": [] + }, + { + "id": "9974", + "type": "gene", + "text": "The sense of self .", + "entities": [] + }, + { + "id": "9975", + "type": "gene", + "text": "Mutational analysis of potential activating phosphorylation sites found in NIMA , NIM - 1 , and related protein kinases was performed on NIMA .", + "entities": [ + "NIMA", + "NIM - 1", + "NIMA" + ] + }, + { + "id": "9976", + "type": "gene", + "text": "In rubella patients with serologic confirmation by HI , the IF test detected significant rises in 219 ( 99 . 1 % ) of 221 patients and the PHA test detected antibody conversion in 68 ( 93 % ) of 73 patients .", + "entities": [ + "PHA" + ] + }, + { + "id": "9977", + "type": "gene", + "text": "On admission to our department in September , 1987 , the patient was alert and had spastic paraparesis , the impairment of all sensory modalities below the level of Th 10 and urinary disturbance .", + "entities": [] + }, + { + "id": "9978", + "type": "gene", + "text": "The insulin therapy regimen did not affect the evolution of the patients and no significant relationship existed between the age at diagnosis , duration of diabetes , daily insulin dosage or metabolic control and height or BMI .", + "entities": [ + "insulin", + "insulin" + ] + }, + { + "id": "9979", + "type": "gene", + "text": "Validation of automated systems - - system definition .", + "entities": [] + }, + { + "id": "9980", + "type": "gene", + "text": "Deletion of fdsR revealed a dual regulatory effect of FdsR on the fds operon by acting as transcriptional activator in the presence of formate or as repressor in the absence of formate .", + "entities": [ + "fdsR", + "FdsR", + "fds operon" + ] + }, + { + "id": "9981", + "type": "gene", + "text": "Regulation of RhoA is required to maintain adhesion in stationary cells , but is also critical for cell spreading and migration [ 3 ] .", + "entities": [ + "RhoA" + ] + }, + { + "id": "9982", + "type": "gene", + "text": "A newly synthesized anti - inflammatory agent , Y - 8004 demonstrated a greater inhibition than did indomethacin ( IM ) . on inflammatory response such as ultraviolet erythema in guinea pigs , carrageenin edema , evans blue and carrageenin - induced pleuritis and acetic acid - induced peritonitis in rats .", + "entities": [] + }, + { + "id": "9983", + "type": "gene", + "text": "When 10 fields were analysed , a strong relationship was found between the presence of bacteria on Gram staining and the final diagnosis of VAP ( for PSB and PTC respectively : sensitivity 74 and 81 % , specificity 94 and 100 % , positive predictive value 91 and 100 % , negative predictive value 82 and 88 % ) .", + "entities": [] + }, + { + "id": "9984", + "type": "gene", + "text": "This is concluded from the isolation of cDNAs from spinach ( Spinacia oleracea ) and barley ( Hordeum vulgare cv .", + "entities": [] + }, + { + "id": "9985", + "type": "gene", + "text": "The following data were recorded at arrival in the intensive care unit 6 , 12 , 24 , and 48 hours after termination of CPB : heart rate , blood pressure , left atrial pressure , central - peripheral temperature difference , arterial - central venous oxygen saturation difference , urine output , serum creatinine , lactate and neutrophil elastase levels , the Doppler echocardiographic factors shortening fraction and preejection period / left - ventricular ejection time , and cumulative doses of catecholamines ( epinephrine ) , enoximone , and furosemide .", + "entities": [ + "neutrophil elastase" + ] + }, + { + "id": "9986", + "type": "gene", + "text": "Using varying conditions , three distinct complexes were shown to interact specifically with the NIP region , although only one correlates with repressor activity .", + "entities": [ + "NIP region" + ] + }, + { + "id": "9987", + "type": "gene", + "text": "It was established that intrathecal or intraperitoneal PTFL , elevated the nociceptive threshold for mechanical stimuli in the formalin test in rats .", + "entities": [] + }, + { + "id": "9988", + "type": "gene", + "text": "These same regions showed remarkable homology to two invertebrate proteins , CNC and skin - 1 , postulated to regulate embryonic development in Drosophila melanogaster and Caenorhabditis elegans , respectively .", + "entities": [ + "CNC", + "skin - 1" + ] + }, + { + "id": "9989", + "type": "gene", + "text": "The peptide sequence contains a region of 80 amino acids that shows similarity to bcl - 2 and to the recently described bcl - 2 - related gene , MCL1 .", + "entities": [ + "bcl - 2", + "bcl - 2 - related gene", + "MCL1" + ] + }, + { + "id": "9990", + "type": "gene", + "text": "1 - ( 1 - Naphthyl ) piperazine ( 1 - NP ) has been reported to have serotonin antagonist properties at the 5 - HT2 subtype of receptor , and it has been suggested that it may have agonist actions at the 5 - HT1 site .", + "entities": [ + "5 - HT2 subtype", + "5 - HT1 site" + ] + }, + { + "id": "9991", + "type": "gene", + "text": "Piroxicam produced a lower incidence of gastric ulcers than equivalent doses of indomethacin .", + "entities": [] + }, + { + "id": "9992", + "type": "gene", + "text": "However , Cbf5p was found to be nucleolar and is highly homologous to the rat nucleolar protein NAP57 , which coimmunoprecipitates with Nopp140 and which is postulated to be involved in nucleolar - cytoplasmic shuttling ( U .", + "entities": [ + "Cbf5p", + "rat nucleolar protein NAP57", + "Nopp140" + ] + }, + { + "id": "9993", + "type": "gene", + "text": "In yeast , the products of the UPF1 and UPF3 genes are required for this decay pathway , and in this report we focus on the identification and characterization of additional factors required for rapid decay of nonsense - containing mRNAs .", + "entities": [ + "UPF1", + "UPF3 genes" + ] + }, + { + "id": "9994", + "type": "gene", + "text": "Zn ( II ) coordination domain mutants of T4 gene 32 protein .", + "entities": [ + "gene 32" + ] + }, + { + "id": "9995", + "type": "gene", + "text": "Zn ( II ) coordination domain mutants of T4 gene 32 protein .", + "entities": [ + "T4 gene 32 protein" + ] + }, + { + "id": "9996", + "type": "gene", + "text": "The daily administration of betamethasone for three weeks markedly reduced the absorption of calcium and phosphate as well as the growth rate .", + "entities": [] + }, + { + "id": "9997", + "type": "gene", + "text": "A simple registration as an incentive for improvement", + "entities": [] + }, + { + "id": "9998", + "type": "gene", + "text": "E2F activity is regulated in part by the retinoblastoma family of tumor suppressor proteins .", + "entities": [ + "E2F", + "retinoblastoma family of tumor suppressor proteins" + ] + }, + { + "id": "9999", + "type": "gene", + "text": "Different thermoluminescent detectors ( TLD ) have been used to measure the contribution of the low linear energy transfer component ( LET < 10 keV / micrometer ) and plastic nuclear track detectors ( PNTD ) for the high linear energy tranfer ( LET ) component .", + "entities": [] + }, + { + "id": "10000", + "type": "gene", + "text": "An industry - wide retrospective cohort mortality study was conducted on 6 , 152 chemical workers ( 2 , 460 exposed and 3 , 692 nonexposed ) engaged in chloromethyl ether manufacture at 7 major U . S . companies between 1948 and 1980 .", + "entities": [] + }, + { + "id": "10001", + "type": "gene", + "text": "A minimal ER3 sequence of DNA was further demonstrated to function as a FXR HRE and was bound in vitro by FXR - expressing yeast extracts .", + "entities": [ + "FXR HRE", + "FXR" + ] + }, + { + "id": "10002", + "type": "gene", + "text": "The FBF questionnaire did not highlight a characteristic basic symptoms profile of schizoaffective disorder , when compared with bipolar affective disorder and schizophrenia .", + "entities": [] + }, + { + "id": "10003", + "type": "gene", + "text": "In Saccharomyces cerevisiae , entry into mitosis requires activation of the cyclin - dependent kinase Cdc28 in its cyclin B ( Clb ) - associated form .", + "entities": [ + "Cdc28", + "cyclin B", + "Clb" + ] + }, + { + "id": "10004", + "type": "gene", + "text": "The carcinoma was restricted within the epithelium in one , the mucosal layer in five , and the submucosal layer in two .", + "entities": [] + }, + { + "id": "10005", + "type": "gene", + "text": "Role of histoclinical studies in the prophylaxis of spontaneous abortions", + "entities": [] + }, + { + "id": "10006", + "type": "gene", + "text": "The core of this enhancer contains two evolutionarily conserved binding sites for the homeodomain protein Tinman ( Tin ) , expressed in developing cardiac , somatic , and visceral muscle lineages .", + "entities": [ + "Tinman", + "Tin" + ] + }, + { + "id": "10007", + "type": "gene", + "text": "Altogether , we confirm that all genes of the Rad52 recombinational repair pathway are required for the survival of rad27 Delta strains at both permissive ( 23 degrees C ) and semipermissive ( 30 degrees C ) temperatures for growth .", + "entities": [ + "Rad52", + "rad27 Delta" + ] + }, + { + "id": "10008", + "type": "gene", + "text": "In gel retardation assays , an RCS cell - specific protein and another closely related protein expressed only in RCS cells and primary chondrocytes bound to a 10 - bp sequence within the 18 - mer .", + "entities": [] + }, + { + "id": "10009", + "type": "gene", + "text": "We investigate the reaction kinetics of small spherical particles with inertia , obeying coalescence type of reaction , B + B - - > B , and being advected by hydrodynamical flows with time - periodic forcing .", + "entities": [] + }, + { + "id": "10010", + "type": "gene", + "text": "The examination was focused on assessment of different types of drusen , on evaluation of the development and incidence of risk factors leading to complications and loss of central vision .", + "entities": [] + }, + { + "id": "10011", + "type": "gene", + "text": "Depletion of dopamine in the nucleus accumbens led to a dramatic shift in behavior in which there was a significant decrease in lever pressing but a significant increase in consumption of lab chow .", + "entities": [] + }, + { + "id": "10012", + "type": "gene", + "text": "Transforming growth factor - beta1 ( TGF - beta1 ) can act as a tumor suppressor or a tumor promoter depending on the characteristics of the malignant cell .", + "entities": [ + "Transforming growth factor - beta1", + "TGF - beta1" + ] + }, + { + "id": "10013", + "type": "gene", + "text": "Drag reduction in turbulent flows by polymers .", + "entities": [] + }, + { + "id": "10014", + "type": "gene", + "text": "The major 49 - kDa core protein in the liver HSPG preparation was found to be reactive to an antibody that specifically recognizes the cytoplasmic domain of fibroglycan .", + "entities": [ + "major 49 - kDa core protein", + "HSPG", + "fibroglycan" + ] + }, + { + "id": "10015", + "type": "gene", + "text": "The effects of several opioid agonists and the opioid antagonist naloxone were examined in rats responding under a fixed - consecutive - number ( FCN ) schedule .", + "entities": [] + }, + { + "id": "10016", + "type": "gene", + "text": "Based on the hypothesis that evolutionarily conserved regions are functionally important and likely to interact with coactivators , we compared the amino acid sequence of C / EBPalpha from different species ( frog to human ) and identified four highly conserved regions ( CR1 - CR4 ) within the transactivation domain .", + "entities": [ + "C / EBPalpha" + ] + }, + { + "id": "10017", + "type": "gene", + "text": "With NEU overexpression , nodal control decreased from 72 % to 34 % ( p = . 008 ) .", + "entities": [ + "NEU" + ] + }, + { + "id": "10018", + "type": "gene", + "text": "Co - transfection of expression vectors for CCAAT / enhancer binding protein ( C / EBP ) alpha and C / EBP beta trans - activated the rat uncoupling protein gene promoter due to sequences in the 5 ' proximal region .", + "entities": [ + "CCAAT / enhancer binding protein ( C / EBP ) alpha", + "C / EBP beta", + "rat uncoupling protein gene promoter" + ] + }, + { + "id": "10019", + "type": "gene", + "text": "Secondly , an ethanol repression autoregulation ( ERA ) / twelve - fold TA repeat ( TAB ) repressor element was identified within the promoter region of the GLK1 gene .", + "entities": [ + "GLK1 gene" + ] + }, + { + "id": "10020", + "type": "gene", + "text": "Variety of cows and sires according to types of dermatoglyphics ( patterns ) of the nose - labial mirror of cattle", + "entities": [] + }, + { + "id": "10021", + "type": "gene", + "text": "Additionally , although c - fos and egr - 1 mRNAs are expressed at elevated levels in stimulated liver cells , fos - B , fra - 1 , and egr - 2 are not , which suggests that factors in addition to the serum response factor participate in the regulation of immediate - early gene induction .", + "entities": [ + "c - fos", + "egr - 1 mRNAs", + "fos - B", + "fra - 1", + "egr - 2", + "serum response factor", + "immediate - early gene" + ] + }, + { + "id": "10022", + "type": "gene", + "text": "( 1994 , Hum .", + "entities": [] + }, + { + "id": "10023", + "type": "gene", + "text": "All adults attending the outpatient clinics of a dermatological hospital on predetermined days were given the 12 - item General Health Questionnaire .", + "entities": [] + }, + { + "id": "10024", + "type": "gene", + "text": "A high degree of correlation in the sense of the classic conception of brain localization of neuropsychological syndromes was found .", + "entities": [] + }, + { + "id": "10025", + "type": "gene", + "text": "The characteristic feature of liver and spleen MP function in patients with VHA associated with HBsAg carriership consisted in the lack of the compensatory reaction on the part of spleen MP , which was likely to be connected with overstrain of long standing and depletion of the MP system due to permanent antigenic stimulation of HBsAg .", + "entities": [ + "HBsAg", + "HBsAg" + ] + }, + { + "id": "10026", + "type": "gene", + "text": "The wild - type and altered forms of the F protein were expressed in BHK - 21 and HeLa T4 cells by use of the recombinant vaccinia virus - encoding T7 polymerase system .", + "entities": [ + "F protein", + "recombinant vaccinia virus - encoding T7 polymerase" + ] + }, + { + "id": "10027", + "type": "gene", + "text": "Very small deletions within the conserved region completely abolished transforming activity of dbl , while extensive deletion outside of this region had no effect .", + "entities": [ + "dbl" + ] + }, + { + "id": "10028", + "type": "gene", + "text": "The abscess was debrided and the septum was patched with a single layer of autologous pericardium .", + "entities": [] + }, + { + "id": "10029", + "type": "gene", + "text": "In experiment 2 , no difference in gastric emptying of 40 % peptone or 25 % glucose was found between rats receiving TPN and those receiving intragastric nutrition for 10 to 12 days .", + "entities": [] + }, + { + "id": "10030", + "type": "gene", + "text": "The analysis of the prevalence values shows clearly that the global MS - frequency is closer related to the geomagnetic than to the geographic latitude .", + "entities": [] + }, + { + "id": "10031", + "type": "gene", + "text": "The expression of the putative operon bglPH of Bacillus subtilis was studied by using bglP ' - lacZ transcriptional fusions .", + "entities": [ + "bglPH", + "bglP '", + "lacZ" + ] + }, + { + "id": "10032", + "type": "gene", + "text": "Harmful effects in animals and man may result from both deficient or excessive amounts of intake .", + "entities": [] + }, + { + "id": "10033", + "type": "gene", + "text": "The differences among subgenera of the genus Dermacentor are more significant .", + "entities": [] + }, + { + "id": "10034", + "type": "gene", + "text": "Only fully processed Pra ( N0 and Nb ) and ICP35 ( ICP35 e , f ) are present in B capsids , which are believed to be precursors of mature virions .", + "entities": [ + "Pra", + "ICP35", + "ICP35 e , f" + ] + }, + { + "id": "10035", + "type": "gene", + "text": "Similarly , comparison of percentage reductions of heart rate at supine , sitting and exercise by repeated measure analysis showed the Malays to have significantly higher change compared to the Chinese ( p = 0 . 040 ) .", + "entities": [] + }, + { + "id": "10036", + "type": "gene", + "text": "Regionalization of drug delivery is a potential method to avoid this problem .", + "entities": [] + }, + { + "id": "10037", + "type": "gene", + "text": "Among non - cirrhotics , lack of portal vein visualisation had a 90 % sensitivity , 88 % specificity , 94 % negative predictive value , and 83 % positive predictive value in the diagnosis of pre - sinusoidal portal hypertension .", + "entities": [] + }, + { + "id": "10038", + "type": "gene", + "text": "A511 is a broad - host - range , virulent myovirus for Listeria monocytogenes .", + "entities": [] + }, + { + "id": "10039", + "type": "gene", + "text": "The stability of isoniazid solutions increases markedly with increasing NTA or EDTA concentration up to 1 mmol / l .", + "entities": [] + }, + { + "id": "10040", + "type": "gene", + "text": "This effect was observed in the absence of de novo protein synthesis and was independent of histone deacetylase activity .", + "entities": [ + "histone deacetylase" + ] + }, + { + "id": "10041", + "type": "gene", + "text": "Thus , endemic cumlations of hepatitis A diseases are possible .", + "entities": [] + }, + { + "id": "10042", + "type": "gene", + "text": "Similar experiments with TR support the high affinity of RIP140 to the RXR subunit and also suggest that either partner in the TR / RXR heterodimer can independently respond to ligand .", + "entities": [ + "TR", + "RIP140", + "RXR subunit", + "TR", + "RXR" + ] + }, + { + "id": "10043", + "type": "gene", + "text": "Commun .", + "entities": [] + }, + { + "id": "10044", + "type": "gene", + "text": "Amino acid residues 147 - 167 of the previously reported sequence are replaced by new residues 147 to 150 .", + "entities": [] + }, + { + "id": "10045", + "type": "gene", + "text": "Raf is a key serine - threonine protein kinase which participates in the transmission of growth , anti - apoptotic and differentiation messages .", + "entities": [ + "Raf", + "serine - threonine protein kinase" + ] + }, + { + "id": "10046", + "type": "gene", + "text": "These properties indicate that Gle1 is an RNA - export factor and that Rev may mediate viral RNA export by mimicking the function of Gle1 .", + "entities": [ + "Gle1", + "Rev", + "Gle1" + ] + }, + { + "id": "10047", + "type": "gene", + "text": "Many cells were negative for endothelial - cell markers , and they reacted with a monoclonal antibody against muscle actin .", + "entities": [ + "actin" + ] + }, + { + "id": "10048", + "type": "gene", + "text": "BACKGROUND : There is increasing interest on the part of investigators and the public at large in finding ways to study and improve treatments for the seriously mentally ill without exposing such individuals to unnecessary risks .", + "entities": [] + }, + { + "id": "10049", + "type": "gene", + "text": "The DNA sequence adjacent to the lacZ gene has been determined for 91 vegetative fusion genes whose products have been localized and for 43 meiotically induced fusions .", + "entities": [ + "lacZ gene" + ] + }, + { + "id": "10050", + "type": "gene", + "text": "Furthermore , the striking ability of polyoma middle T antigens to promote retinoic acid - induced differentiation appears to utilize ERK , but not JNK / SPK or p38 signaling .", + "entities": [ + "polyoma middle T antigens", + "ERK", + "JNK", + "SPK", + "p38" + ] + }, + { + "id": "10051", + "type": "gene", + "text": "Possibility of a TSH - Screening method for detection of hypothyroidism in the newborn", + "entities": [ + "TSH" + ] + }, + { + "id": "10052", + "type": "gene", + "text": "We conclude that TA caused a specific decrease in AGD on GD 20 that was largely reversed by PCD 23 .", + "entities": [] + }, + { + "id": "10053", + "type": "gene", + "text": "Analysis of a Mac1p mutant , refractile for copper - dependent repression of the Cu ( I ) transport genes , showed an aberrant pattern of CUP1 expression and copper sensitivity .", + "entities": [ + "Mac1p mutant", + "Cu ( I ) transport genes", + "CUP1" + ] + }, + { + "id": "10054", + "type": "gene", + "text": "The presence of cutaneous xanthomas with normal serum lipid levels is due to the antibetalipoproteic activity of the monoclonal immunoglobulin .", + "entities": [ + "monoclonal immunoglobulin" + ] + }, + { + "id": "10055", + "type": "gene", + "text": "Binding of SSP to the stage selector element ( SSE ) in the proximal gamma - globin promoter is integral to the competitive silencing of a linked beta - promoter in embryonic / fetal stage erythroleukemia ( K562 ) cells .", + "entities": [ + "SSP", + "stage selector element", + "SSE", + "gamma - globin promoter", + "beta - promoter" + ] + }, + { + "id": "10056", + "type": "gene", + "text": "Because of serious infections ( fever larger than or equal to 101 degrees F . granulocytes less than 1 , 000 / mm , 3 and hospitalization ) and 1 drug death in the first 4 patients , oral calcium leucovorin , 20 to 30 mg / m2 orally , was given 2 days after methotrexate in subsequent treatment cycles .", + "entities": [] + }, + { + "id": "10057", + "type": "gene", + "text": "The rat branched - chain - 2 - oxo - acid dehydrogenase ( BCOD ) kinase mRNA is transcribed from a TATA - less promoter that has GC - rich sequences and two putative Sp1 binding sites near the transcription start site .", + "entities": [ + "rat branched - chain - 2 - oxo - acid dehydrogenase ( BCOD ) kinase mRNA", + "Sp1 binding sites" + ] + }, + { + "id": "10058", + "type": "gene", + "text": "These results suggest that 5 KE X 3 / W may be the optimal regimen to augment the antitumor immunity of RNL .", + "entities": [] + }, + { + "id": "10059", + "type": "gene", + "text": "In vitro antimalarial activity of neem ( Azadirachta indica A .", + "entities": [] + }, + { + "id": "10060", + "type": "gene", + "text": "The existence of threshold concentrations , above which certain phenomena may occur , strengthens the role of sentinels .", + "entities": [] + }, + { + "id": "10061", + "type": "gene", + "text": "To study the mechanisms as well as magnitude of the transmembrane transfer of bacterial products from the dialysate , we developed a computerized in vitro dialysis model which provides continuous pressure recording from the arterial , venous , dialysate inflow and outflow ports .", + "entities": [] + }, + { + "id": "10062", + "type": "gene", + "text": "At cross purposes .", + "entities": [] + }, + { + "id": "10063", + "type": "gene", + "text": "Histamine metabolism in hemorrhagic - hypotensive shock", + "entities": [] + }, + { + "id": "10064", + "type": "gene", + "text": "These data indicate that although 218leu retains normal transactivation activity on a p53 promoter in yeast at physiological temperatures , it is not capable of normal p53 function in the presence of a 248trp allele in SNU - C5 cells .", + "entities": [ + "p53 promoter", + "p53", + "248trp allele" + ] + }, + { + "id": "10065", + "type": "gene", + "text": "The close proximity of the two neuropeptide Y receptor genes suggests that they have evolved from a gene duplication event with the small intron interrupting the coding sequence of the y1 gene being converted into a functional sequence within the y5 gene , while the reverse complementary sequence was utilized as an alternatively spliced 5 ' exon for the y1 gene .", + "entities": [ + "neuropeptide Y receptor genes", + "y1 gene", + "y5 gene", + "y1 gene" + ] + }, + { + "id": "10066", + "type": "gene", + "text": "Overexpression of PTTG in transfected NIH 3T3 cells also stimulated expression and secretion of basic fibroblast growth factor , a human pituitary tumor growth - regulating factor .", + "entities": [ + "PTTG", + "basic fibroblast growth factor", + "human pituitary tumor growth - regulating factor" + ] + }, + { + "id": "10067", + "type": "gene", + "text": "MDBP from HeLa and Raji cells formed DNA - protein complexes with X - box oligonucleotides that coelectrophoresed with those containing standard MDBP sites .", + "entities": [ + "MDBP", + "MDBP sites" + ] + }, + { + "id": "10068", + "type": "gene", + "text": "A careful , radiolabelled tissue - distribution study is warranted to elucidate the complicated metabolic fate of perhexiline .", + "entities": [] + }, + { + "id": "10069", + "type": "gene", + "text": "Merr . ) embryo library .", + "entities": [] + }, + { + "id": "10070", + "type": "gene", + "text": "The strategies by which hepatitis B and hepatitis D can be diminished and eventually eliminated are : immunization , measures to prevent exposure to infective blood or blood derivatives and education ( in particular awareness that hepatitis B is a sexually transmitted disease ) .", + "entities": [] + }, + { + "id": "10071", + "type": "gene", + "text": "Invited editorial on \" Acute and chronic effects of exercise on leptin levels in humans \" .", + "entities": [ + "leptin" + ] + }, + { + "id": "10072", + "type": "gene", + "text": "Chronic hypophosphatemia is the most common type of \" resistant \" rickets .", + "entities": [] + }, + { + "id": "10073", + "type": "gene", + "text": "This indicates that under certain experimental conditions cdc2 / p58 and cdc2 / p62 may express some differences in their catalytic activity .", + "entities": [ + "cdc2", + "p58", + "cdc2", + "p62" + ] + }, + { + "id": "10074", + "type": "gene", + "text": "Interferon - alpha treatment of posttransplant lymphoproliferative disorder in recipients of solid organ transplants .", + "entities": [ + "Interferon - alpha" + ] + }, + { + "id": "10075", + "type": "gene", + "text": "Stress - inducible protein kinases capable of activating c - jun expression include stress - activated protein kinase / c - Jun N - terminal protein kinase ( SAPK / JNK ) and p38 members of the mitogen - activated protein kinase ( MAPK ) superfamily of signaling molecules .", + "entities": [ + "Stress - inducible protein kinases", + "c - jun", + "stress - activated protein kinase", + "c - Jun N - terminal protein kinase", + "SAPK", + "JNK", + "p38", + "mitogen - activated protein kinase", + "MAPK" + ] + }, + { + "id": "10076", + "type": "gene", + "text": "False positive amniotic fluid alpha fetoprotein levels resulting from contamination with fetal blood : results of an experiment .", + "entities": [ + "amniotic fluid alpha fetoprotein" + ] + }, + { + "id": "10077", + "type": "gene", + "text": "A new variant of the EMG - BFB method ( multichannel ) is offered which has made it possible to use the method not only for training weakened muscles and reducing spasticity in their antagonists but also for improving motor coordination .", + "entities": [] + }, + { + "id": "10078", + "type": "gene", + "text": "HIV - 1 C subtype in IDUs accounted for 61 . 3 % .", + "entities": [] + }, + { + "id": "10079", + "type": "gene", + "text": "Phagocytosis of tubercle bacilli by macrophages .", + "entities": [] + }, + { + "id": "10080", + "type": "gene", + "text": "Identification of pulmonary vein stenosis after radiofrequency ablation for atrial fibrillation using MRI .", + "entities": [] + }, + { + "id": "10081", + "type": "gene", + "text": "In addition , there was a significant increase in postdexamethasone cortical concentrations with age ( p less than 0 . 01 ; r = 0 . 31 ) .", + "entities": [] + }, + { + "id": "10082", + "type": "gene", + "text": "Diagnosis and differential diagnosis", + "entities": [] + }, + { + "id": "10083", + "type": "gene", + "text": "Effect of noise on CO - induced increases of LAP and GPT activity in the plasma of rats", + "entities": [ + "LAP", + "GPT" + ] + }, + { + "id": "10084", + "type": "gene", + "text": "Their use resulted in a sensitivity of 73 % and a specificity of 74 % with regard to predictability of ALT levels increasing during the trial .", + "entities": [ + "ALT" + ] + }, + { + "id": "10085", + "type": "gene", + "text": "Structural characteristics of the erythrocyte membrane , peroxidation processes and antioxidant function in children with diffuse glomerulonephritis", + "entities": [] + }, + { + "id": "10086", + "type": "gene", + "text": "After selection and conversion to adipocytes , the level of EGFR expression was retained in infectant adipocytes ( 150 , 000 and 250 , 000 / cell , respectively ) , but not in the parental 3T3 - L1 adipocytes ( < 5000 / cell ) .", + "entities": [ + "EGFR" + ] + }, + { + "id": "10087", + "type": "gene", + "text": "DESIGN AND METHODS : Case study .", + "entities": [] + }, + { + "id": "10088", + "type": "gene", + "text": "Evidence - based care : a new formula for an old problem ?", + "entities": [] + }, + { + "id": "10089", + "type": "gene", + "text": "Co - existence of these regulatory elements with other elements , such as the AP - 2 element or CCAAT box , was also found .", + "entities": [ + "AP - 2 element" + ] + }, + { + "id": "10090", + "type": "gene", + "text": "We have shown previously that GH3 cells transfected with the rat GnRH receptor cDNA ( GGH3 - 1 ' cells ) support the expression of a cotransfected fusion gene composed of 797 base pairs of rat LHbeta gene 5 ' - flanking sequence and the first 5 base pairs of the 5 ' - untranslated region fused to a luciferase reporter ( - 797 / + 5LHbetaLUC ) and respond to a GnRH agonist with a 10 - fold stimulation of activity .", + "entities": [ + "rat GnRH receptor cDNA", + "rat LHbeta gene 5 ' - flanking sequence", + "luciferase reporter ( - 797 / + 5LHbetaLUC )", + "GnRH" + ] + }, + { + "id": "10091", + "type": "gene", + "text": "Identification , purification , and molecular cloning of autonomously replicating sequence - binding protein 1 from fission yeast Schizosaccharomyces pombe .", + "entities": [ + "autonomously replicating sequence - binding protein 1 from fission yeast Schizosaccharomyces pombe" + ] + }, + { + "id": "10092", + "type": "gene", + "text": "The femoral artery / vein and the soleus and gastrocnemius muscles were examined in healthy human male volunteers .", + "entities": [] + }, + { + "id": "10093", + "type": "gene", + "text": "All groups were tested in a Hebb - Williams maze at 100 approximately 10 days of age .", + "entities": [] + }, + { + "id": "10094", + "type": "gene", + "text": "The various muscles of the pelvic floor region could be reflexly activated either individually or as a mass unit depending on the intensity of stimulation .", + "entities": [] + }, + { + "id": "10095", + "type": "gene", + "text": "Two copies of the 72 - bp repeat provided efficient activation of gene expression .", + "entities": [] + }, + { + "id": "10096", + "type": "gene", + "text": "The presence of such a putative RNA - binding domain suggests a mechanism for the observed autoregulation of bacteriophage T4 DNA polymerase synthesis by binding to its own mRNA .", + "entities": [ + "T4 DNA polymerase" + ] + }, + { + "id": "10097", + "type": "gene", + "text": "The lack of the C2 domain of the Ca ( 2 + ) - dependent PKCs and the presence of a unique NH2 - terminal sequence with a potential signal peptide and a transmembrane domain suggest that PKC mu is a novel member of the subgroup of atypical PKCs .", + "entities": [ + "C2", + "Ca ( 2 + ) - dependent PKCs", + "PKC mu", + "PKCs" + ] + }, + { + "id": "10098", + "type": "gene", + "text": "Clones that expressed DBD exhibited a dominant negative phenotype and did not elicit antiviral activity against vesicular stomatitis virus ( VSV ) infection upon IFN treatment .", + "entities": [ + "IFN" + ] + }, + { + "id": "10099", + "type": "gene", + "text": "Post and core fabrication for divergent canals with a cast post and core and a prefabricated dowel .", + "entities": [] + }, + { + "id": "10100", + "type": "gene", + "text": "The six commonest causes of death varied in the three ethnic groups .", + "entities": [] + }, + { + "id": "10101", + "type": "gene", + "text": "Surveillance for preeclampsia was conducted by personnel unaware of treatment - group assignments , using standardized measurements of blood pressure and urinary protein excretion at uniformly scheduled prenatal visits , protocols for monitoring these measurements during the hospitalization for delivery , and reviews of medical records of unscheduled outpatient visits and all hospitalizations .", + "entities": [] + }, + { + "id": "10102", + "type": "gene", + "text": "The Bacillus subtilis phage phi 105 repressor , a lambda repressor - like transcriptional regulatory protein , was overproduced in Escherichia coli and purified to near homogeneity in order to examine its in vitro DNA - binding properties .", + "entities": [ + "Bacillus subtilis phage phi 105 repressor", + "lambda repressor" + ] + }, + { + "id": "10103", + "type": "gene", + "text": "All patients with deterioriation in mental status showed a marked increase in liver enzymes ( aspartate and alanine aminotransaminases ) and severe coagulopathy .", + "entities": [ + "aspartate and alanine aminotransaminases" + ] + }, + { + "id": "10104", + "type": "gene", + "text": "RNA transcripts that hybridize to the introduced foreign gene have been identified .", + "entities": [] + }, + { + "id": "10105", + "type": "gene", + "text": "Deterministic effects .", + "entities": [] + }, + { + "id": "10106", + "type": "gene", + "text": "They are subdivided into two types that activate transduction pathways via different cell surface receptors .", + "entities": [] + }, + { + "id": "10107", + "type": "gene", + "text": "Bupropion to aid smoking cessation .", + "entities": [] + }, + { + "id": "10108", + "type": "gene", + "text": "To prepare for analyses with the family variables , we next present descriptive data based on separate principal components analysis ( PCA ) and multidimensional scaling analysis ( MDS ) of 14 self - reported health scores for husbands and for wives .", + "entities": [] + }, + { + "id": "10109", + "type": "gene", + "text": "Morphofunctional status of the formed elements of the blood in rats subjected to different variants of combined and isolated exposure to BR - 1 benzene", + "entities": [] + }, + { + "id": "10110", + "type": "gene", + "text": "This work unravels a new model for the ets - 1 / ets - 2 gene ' s evolution , based for the first time on both structural and functional evidences .", + "entities": [ + "ets - 1", + "ets - 2 gene" + ] + }, + { + "id": "10111", + "type": "gene", + "text": "We also demonstrate that the spo20 ( + ) gene product is structurally homologous to Saccharomyces cerevisiae Sec14 , the major phosphatidylinositol transfer protein of budding yeast .", + "entities": [ + "spo20 ( + ) gene product", + "Saccharomyces cerevisiae Sec14" + ] + }, + { + "id": "10112", + "type": "gene", + "text": "Using the presented categorical structure as domain model a prototype DSS for dipslide urine cultures has been developed .", + "entities": [] + }, + { + "id": "10113", + "type": "gene", + "text": "CodY does not have any homologues in the data - bases .", + "entities": [ + "CodY" + ] + }, + { + "id": "10114", + "type": "gene", + "text": "The murine MHC class I genes , H - 2Dq and H - 2Lq , are strikingly homologous to each other , H - 2Ld , and two genes reported to encode tumor - specific antigens .", + "entities": [ + "murine MHC class I genes", + "H - 2Dq", + "H - 2Lq", + "H - 2Ld" + ] + }, + { + "id": "10115", + "type": "gene", + "text": "Rind et al . ' s study ' s main conclusions were not supported by the original data .", + "entities": [] + }, + { + "id": "10116", + "type": "gene", + "text": "The proteins are more than 90 % identical to each other within the protein kinase domain but only 51 - 59 % identical to other casein kinase I isoforms within this region .", + "entities": [ + "casein kinase I isoforms" + ] + }, + { + "id": "10117", + "type": "gene", + "text": "CASE REPORT : We observed a congenital skin defect located exclusively on the trunk .", + "entities": [] + }, + { + "id": "10118", + "type": "gene", + "text": "MDS1 / EVI1 , located on chromosome 3 band q26 , encodes a zinc - finger DNA - binding transcription activator not detected in normal hematopoietic cells but expressed in several normal tissues .", + "entities": [ + "MDS1", + "EVI1", + "zinc - finger DNA - binding transcription activator" + ] + }, + { + "id": "10119", + "type": "gene", + "text": "Subretinal fluid was punctured on the poorer eye in 19 eyes ( 52 . 7 % ) and on the better eye in 7 eyes ( 19 . 4 % ) .", + "entities": [] + }, + { + "id": "10120", + "type": "gene", + "text": "According to the literature , second malignant epithelial tumours are , in contrast to mesenchymal tumours such as osteosarcoma , very rare in retinoblastoma survivors .", + "entities": [] + }, + { + "id": "10121", + "type": "gene", + "text": "CREST syndrome ; a changing clinical significance", + "entities": [] + }, + { + "id": "10122", + "type": "gene", + "text": "Recently , studies of agents that disrupt collagen synthesis and deposition have yielded several new angiogenesis inhibitors .", + "entities": [ + "collagen" + ] + }, + { + "id": "10123", + "type": "gene", + "text": "A mutation which abrogates the binding of these factors reduces Wp reporter activity specifically in B cell lines , whereas a mutation which converts the site to a consensus CREB - binding sequence maintains wild - type promoter function .", + "entities": [ + "Wp reporter", + "CREB - binding sequence" + ] + }, + { + "id": "10124", + "type": "gene", + "text": "We also identify several regulatory domain mutants in which Cd ( 2 + ) tolerance of the mutant strain and transport activity of the protein are dissociated .", + "entities": [] + }, + { + "id": "10125", + "type": "gene", + "text": "Aortic diameters in infants and young children : normative angiographic data .", + "entities": [] + }, + { + "id": "10126", + "type": "gene", + "text": "Results demonstrated that the presence of myofibroblasts varied considerably from case to case and was always related to smooth muscle cell dispersion , which occurred around medium - sized damaged portal vein branches .", + "entities": [] + }, + { + "id": "10127", + "type": "gene", + "text": "The carboxy terminus of Mbp1 is sufficient for interaction with Swi6 , and the carboxy terminus of Swi6 is required for interaction with Mbp1 .", + "entities": [ + "Mbp1", + "Swi6", + "Swi6", + "Mbp1" + ] + }, + { + "id": "10128", + "type": "gene", + "text": "Our results suggest that the crucial role of the mutations activating v - erbA as an oncogene is to ' freeze ' c - ErbA / TRalpha in its non - liganded , repressive conformation and to facilitate its overexpression .", + "entities": [ + "v - erbA", + "c - ErbA", + "TRalpha" + ] + }, + { + "id": "10129", + "type": "gene", + "text": "Analysis of SRE oligonucleotide gel mobility shift assays with nuclear extracts from Sertoli cells demonstrated the presence of both the SRF and the ubiquitously expressed bHLH protein E12 / E47 .", + "entities": [ + "SRF", + "E12", + "E47" + ] + }, + { + "id": "10130", + "type": "gene", + "text": "Drug and personnel costs were reduced when batch manufacturing with 40 - mL multidose vials was compared with extemporaneous compounding with unit - dose vials .", + "entities": [] + }, + { + "id": "10131", + "type": "gene", + "text": "These data suggest that mammalian erythroid alpha - spectrin evolved by duplication and rapid divergence from an ancestral alpha - fodrin - like gene .", + "entities": [ + "alpha - spectrin", + "alpha - fodrin - like gene" + ] + }, + { + "id": "10132", + "type": "gene", + "text": "Disruption of the HOG1 and PBS2 genes leads to a dramatic decrease of the HSP12 inducibility in osmostressed cells , whereas overproduction of Hog1 produces a fivefold increase in wild - type induced levels upon a shift to a high salt concentration .", + "entities": [ + "HOG1", + "PBS2 genes", + "HSP12", + "Hog1" + ] + }, + { + "id": "10133", + "type": "gene", + "text": "Differential expression of AP - 2alpha and AP - 2beta in the developing chick retina : repression of R - FABP promoter activity by AP - 2 .", + "entities": [ + "AP - 2alpha", + "AP - 2beta", + "R - FABP promoter", + "AP - 2" + ] + }, + { + "id": "10134", + "type": "gene", + "text": "Electrophoretic mobility shift assays with each of these sequences demonstrated complexes with mobilities identical to those of the NF - kappa B site from the kappa light - chain gene .", + "entities": [ + "NF - kappa B site", + "kappa light - chain gene" + ] + }, + { + "id": "10135", + "type": "gene", + "text": "At cuticular positions exhibiting the Brd bristle loss phenotype , we have found that the progeny of the multiplied SOPs develop aberrantly , in that neurons and thecogen ( sheath ) cells appear but not trichogen ( shaft ) and tormogen ( socket ) cells .", + "entities": [ + "Brd bristle loss phenotype" + ] + }, + { + "id": "10136", + "type": "gene", + "text": "The pea rps10 intron is homologous to introns in rrn26 and cox3 in the Marchantia mitochondrial genome , while the Marchantia rps10 gene lacks an intron .", + "entities": [ + "pea rps10 intron", + "rrn26", + "cox3", + "Marchantia rps10 gene" + ] + }, + { + "id": "10137", + "type": "gene", + "text": "Mutational analyses showed that in - frame stop codons introduced into five of seven RNA 2 ORFs did not affect accumulation of progeny LIYV RNA 1 or RNA 2 , confirming that RNA 2 does not encode proteins necessary for LIYV RNA replication .", + "entities": [ + "RNA 2 ORFs", + "LIYV RNA 1", + "RNA 2", + "RNA 2" + ] + }, + { + "id": "10138", + "type": "gene", + "text": "Appl .", + "entities": [] + }, + { + "id": "10139", + "type": "gene", + "text": "However , a zinc - depleted enzyme was obtained after prolonged dialysis against the specific chelating agent 1 , 10 - phenanthroline .", + "entities": [] + }, + { + "id": "10140", + "type": "gene", + "text": "High ADR1 gene dosage increased the transcription of genes encoding peroxisomal proteins as compared to one copy of the ADR1 gene .", + "entities": [ + "ADR1 gene", + "ADR1 gene" + ] + }, + { + "id": "10141", + "type": "gene", + "text": "It is suggested that these results may raise the interesting possibility of providing a means of identifying greater or lesser susceptibility to the coronary effects of Type A behavior .", + "entities": [] + }, + { + "id": "10142", + "type": "gene", + "text": "We have initiated studies to identify candidate signal transducers that associate with the cytosolic domain ( cd ) of the IL - 1R .", + "entities": [ + "IL - 1R" + ] + }, + { + "id": "10143", + "type": "gene", + "text": "Low - grade glioma .", + "entities": [] + }, + { + "id": "10144", + "type": "gene", + "text": "Factor V Leiden is a genetic disorder associated with an increased risk of venous thrombosis .", + "entities": [] + }, + { + "id": "10145", + "type": "gene", + "text": "Landsberg ( La - O ) and cv .", + "entities": [] + }, + { + "id": "10146", + "type": "gene", + "text": "Further , the osteo - retentive ability of the hydroxyapatite in the sockets was seen to be close to significance ( after six months width differences , in the canine region : P = 0 . 059 , LHS , and P = 0 . 065 , RHS ) .", + "entities": [] + }, + { + "id": "10147", + "type": "gene", + "text": "Using a high - copy suppression strategy , we have identified a yeast gene ( UBS1 ) whose elevated expression suppresses the conditional cell cycle defects associated with cdc34 mutations .", + "entities": [ + "UBS1", + "cdc34" + ] + }, + { + "id": "10148", + "type": "gene", + "text": "The 17 - kDa protein is required for the systemic infection of plants .", + "entities": [] + }, + { + "id": "10149", + "type": "gene", + "text": "Mutational analysis of the major homology region of Mason - Pfizer monkey virus by use of saturation mutagenesis .", + "entities": [] + }, + { + "id": "10150", + "type": "gene", + "text": "When expressed in COS - 7 cells , MKP - 4 blocks activation of MAP kinases with the selectivity ERK > p38 = JNK / SAPK .", + "entities": [ + "MKP - 4", + "MAP kinases", + "ERK", + "p38", + "JNK", + "SAPK" + ] + }, + { + "id": "10151", + "type": "gene", + "text": "Out of 40 patients , who initially did not show eye complications due to leprosy , 37 patients were essentially the same 10 years later .", + "entities": [] + }, + { + "id": "10152", + "type": "gene", + "text": "In order to investigate the blood compatibility of autogenous vein graft ( AVG ) , changes in prostacyclin ( PGI2 ) production following harvesting and arterial implantation were studied experimentally .", + "entities": [] + }, + { + "id": "10153", + "type": "gene", + "text": "We studied the role of prostaglandins in acid - induced esophagitis and the associated LES hypotension by simultaneous treatment of some animals with indomethacin ( 150 micrograms / kg intravenous ) , a specific inhibitor of prostaglandin synthesis , either during production of esophagitis or during recovery .", + "entities": [] + }, + { + "id": "10154", + "type": "gene", + "text": "The hIGF - I gene has two promoters , P1 and P2 .", + "entities": [ + "hIGF - I gene" + ] + }, + { + "id": "10155", + "type": "gene", + "text": "Five families of Ashkenazi Jewish descent carried the 185delAG mutation and shared the same haplotype at eight polymorphic markers spanning approximately 850 kb at BRCA1 .", + "entities": [ + "BRCA1" + ] + }, + { + "id": "10156", + "type": "gene", + "text": "All patients then received suxamethonium 1 . 5 mg kg - 1 i . v .", + "entities": [] + }, + { + "id": "10157", + "type": "gene", + "text": "Data on the line spread function ( LSF ) were obtained from the image of a 0 . 2 mm wide slit between tungsten blocks that were positioned at the isocentre in front of a polystyrene phantom .", + "entities": [] + }, + { + "id": "10158", + "type": "gene", + "text": "Point mutations of the site that suppressed Pit - 1 binding in vitro restored full tiGH promoter activity .", + "entities": [ + "Pit - 1", + "tiGH promoter" + ] + }, + { + "id": "10159", + "type": "gene", + "text": "OBJECTIVE : To perform a cost - effectiveness analysis ( CEA ) between a standard antiemetic regimen - chlorpromazine + dexamethasone ( CPM - DEX ) - and a 5 - HT3 receptor antagonist - tropisetron ( TROP ) - - in the control of acute emesis induced by highly emetogenic chemotherapy in children , considering two analytic perspectives : hospital and patients .", + "entities": [ + "5 - HT3 receptor" + ] + }, + { + "id": "10160", + "type": "gene", + "text": "This emphasizes the conclusion that CDF - 1 is not an E2F family member and points to profound differences in the cell cycle regulation of CDF - 1 and E2F .", + "entities": [ + "CDF - 1", + "E2F family member", + "CDF - 1", + "E2F" + ] + }, + { + "id": "10161", + "type": "gene", + "text": "During most of the cell cycle , separase is kept inactive by binding to an inhibitory protein called securin .", + "entities": [ + "separase", + "securin" + ] + }, + { + "id": "10162", + "type": "gene", + "text": "In PB mice , there was only a small deficit in the number of the hippocampal pyramidal neurons compared to controls ( 15 % , p less than 0 . 01 ) , and no deficit in the granule cells .", + "entities": [] + }, + { + "id": "10163", + "type": "gene", + "text": "Weaned rats were fed a normal diet or a low - protein , low - energy diet , and injected with saline or thyroxine ( 5 micrograms / 100 g BW ) for 22 days .", + "entities": [] + }, + { + "id": "10164", + "type": "gene", + "text": "Four possible isoforms ( hGli2 alpha , beta , gamma , and delta ) are formed by combinations of two independent alternative splicings , and all the isoforms could bind to a DNA motif , TRE2S , in the LTR .", + "entities": [ + "hGli2 alpha , beta , gamma , and delta" + ] + }, + { + "id": "10165", + "type": "gene", + "text": "The psaD , psaF , psaH , and psaL products have two isoforms each that are distinguished by different mobilities in polyacrylamide gel electrophoresis , and the psaE product has four isoforms .", + "entities": [ + "psaD", + "psaF", + "psaH", + "psaL products", + "psaE product" + ] + }, + { + "id": "10166", + "type": "gene", + "text": "Calcimimetic agents directly inhibit PTH secretion by activating the calcium - sensing receptor in the parathyroid glands , but clinical experience with them is limited .", + "entities": [ + "PTH" + ] + }, + { + "id": "10167", + "type": "gene", + "text": "For the 2 . 5 to 4 ng / mL model , the AUC of the ANN ROC curve was significantly higher than the AUCs for percentage of free PSA ( P = . 0239 ) , PSA - TZ ( P = . 0204 ) , and PSA density and total prostate volume ( P < . 01 for both ) .", + "entities": [ + "PSA", + "PSA" + ] + }, + { + "id": "10168", + "type": "gene", + "text": "Failures of colorimetric additivity under these experimental conditions are discussed .", + "entities": [] + }, + { + "id": "10169", + "type": "gene", + "text": "Active complexes eluted at a higher molecular weight than inactive complexes , were relatively deficient in both p21 and p27 , and contained Cdk2 with increased threonine 160 phosphorylation , consistent with a mechanism of activation of cyclin E - Cdk2 involving both reduced CDK inhibitor association and CDK - activating kinase - mediated phosphorylation of Cdk2 .", + "entities": [ + "p21", + "p27", + "Cdk2", + "cyclin E", + "Cdk2", + "CDK", + "CDK - activating kinase", + "Cdk2" + ] + }, + { + "id": "10170", + "type": "gene", + "text": "Coronary T1 and T2 weighted images were obtained .", + "entities": [] + }, + { + "id": "10171", + "type": "gene", + "text": "Constitutive phosphorylation of the CD30v protein was demonstrated by in vitro labeling with [ 32P ] .", + "entities": [ + "CD30v protein" + ] + }, + { + "id": "10172", + "type": "gene", + "text": "Preliminary report .", + "entities": [] + }, + { + "id": "10173", + "type": "gene", + "text": "We have isolated and sequenced the gene encoding the human U1 - 70K snRNP protein .", + "entities": [ + "human U1 - 70K snRNP protein" + ] + }, + { + "id": "10174", + "type": "gene", + "text": "We studied the functional interaction between human embryonic zeta 2 globin promoter and the alpha globin regulatory element ( HS - 40 ) located 40 kb upstream of the zeta 2 globin gene .", + "entities": [ + "zeta 2 globin", + "alpha globin regulatory element", + "HS - 40", + "zeta 2 globin gene" + ] + }, + { + "id": "10175", + "type": "gene", + "text": "No patient in group 2 developed HAT ( P = 0 . 006 versus group 1 ) .", + "entities": [] + }, + { + "id": "10176", + "type": "gene", + "text": "The Scm and ph proteins share a homology domain with 38 % identity over a length of 65 amino acids , termed the SPM domain , that is located at their respective C termini .", + "entities": [ + "Scm", + "ph" + ] + }, + { + "id": "10177", + "type": "gene", + "text": "The Novacor Left Ventricular Assist System ( LVAS ) ( Novacor Corp , Oakland , CA ) was initially console - based and has been available since 1993 in a wearable configuration .", + "entities": [] + }, + { + "id": "10178", + "type": "gene", + "text": "Two members of the Cbl family have since been defined in mammals ( c - Cbl and Cbl - b ) , one in C . elegans ( Sli - 1 ) and one in Drosophila ( D - Cbl ) .", + "entities": [ + "Cbl family", + "c - Cbl", + "Cbl - b", + "Sli - 1", + "D - Cbl" + ] + }, + { + "id": "10179", + "type": "gene", + "text": "Replication of bovine papillomavirus - 1 ( BPV - 1 ) DNA requires two viral gene products , the E1 protein and the full - length E2 protein .", + "entities": [ + "E1 protein", + "full - length E2 protein" + ] + }, + { + "id": "10180", + "type": "gene", + "text": "Low MAO subjects showed a pattern of higher scores in KSP Impulsiveness , EPQ Neuroticism , and KSP Somatic Anxiety and Irritability and lower scores in KSP Socialization , in line with personality profiles found in alcoholics , psychopaths , and suicide attempters who also tend to have low platelet MAO activity .", + "entities": [ + "MAO", + "MAO" + ] + }, + { + "id": "10181", + "type": "gene", + "text": "The protein ELT - 1 , encoded by a single - copy gene homologous to the GATA family of vertebrate transcription factors , is potentially capable of interacting with this element .", + "entities": [ + "protein ELT - 1", + "GATA family of vertebrate transcription factors" + ] + }, + { + "id": "10182", + "type": "gene", + "text": "The C - terminal region of the 150 - kDa protein contains an NTP - binding helicase motif and the readthrough region , an RNA polymerase motif , indicating that these two overlapping proteins may form an RNA replication complex similar to those of tobamo - and tobraviruses .", + "entities": [ + "helicase motif", + "RNA polymerase motif" + ] + }, + { + "id": "10183", + "type": "gene", + "text": "5 microU / l thyrotropin : 75 % ( 1974 ) , 45 % ( 1977 ) and 20 % ( 1980 ) .", + "entities": [ + "thyrotropin" + ] + }, + { + "id": "10184", + "type": "gene", + "text": "Considerably high levels of IgE antibodies was also established while other pollens did not show such correspondence .", + "entities": [ + "IgE antibodies" + ] + }, + { + "id": "10185", + "type": "gene", + "text": "All runners drank a total of 1 . 4 L of water during the race .", + "entities": [] + }, + { + "id": "10186", + "type": "gene", + "text": "Partial N - terminal amino acid sequence analysis showed that the 43K and 42K T antigens contain methionine at residues 1 and 5 , as predicted from the DNA sequence , whereas no methionine was released from the 39K T antigen during the first six cycles of Edman degradation .", + "entities": [ + "43K and 42K T antigens", + "39K T antigen" + ] + }, + { + "id": "10187", + "type": "gene", + "text": "This activation was then blocked by CGS 12066A .", + "entities": [] + }, + { + "id": "10188", + "type": "gene", + "text": "IX .", + "entities": [] + }, + { + "id": "10189", + "type": "gene", + "text": "Hydrocoele is common in men in Wuchereria bancrofti - endemic areas , the treatment for which is currently surgical intervention .", + "entities": [] + }, + { + "id": "10190", + "type": "gene", + "text": "We have isolated three mutant alleles of CDC4 ( cdc4 - 10 , cdc4 - 11 , and cdc4 - 16 ) which suppress the nuclear division defect of cdc20 - 1 cells .", + "entities": [ + "CDC4", + "cdc4 - 10", + "cdc4 - 11", + "cdc4 - 16", + "cdc20 - 1" + ] + }, + { + "id": "10191", + "type": "gene", + "text": "All four doubly tyrosine phosphorylated TAM peptides cross - compete with each other for binding to the tandem SH2 domains of ZAP - 70 .", + "entities": [ + "SH2 domains", + "ZAP - 70" + ] + }, + { + "id": "10192", + "type": "gene", + "text": "Estrogen replacement therapy and risk of breast cancer : results of two meta - analyses .", + "entities": [] + }, + { + "id": "10193", + "type": "gene", + "text": "Moreover , the second RCC1 - like motif located at the amino - terminus of p619 stimulates guanine nucleotide exchange on ARF1 and on members of the related Rab proteins , but not on other small GTP binding proteins such as Ran or R - Ras2 / TC21 .", + "entities": [ + "RCC1 - like motif", + "p619", + "ARF1", + "Rab proteins", + "small GTP binding proteins", + "Ran", + "R - Ras2", + "TC21" + ] + }, + { + "id": "10194", + "type": "gene", + "text": "Drug inhibition of whole blood aspirin esterase .", + "entities": [ + "aspirin esterase" + ] + }, + { + "id": "10195", + "type": "gene", + "text": "A needs assessment of these families was also done .", + "entities": [] + }, + { + "id": "10196", + "type": "gene", + "text": "Following intravenous administration , the myocardial concentration of tracer thallium - 201 , potassium - 43 , and rubidium - 81 were determined in mice ; thallium was present in the greatest concentration in the myocardium ( 2 . 08 % compared 1 . 25 % for potassium and 1 . 15 % for rubidium at 10 minutes ) .", + "entities": [] + }, + { + "id": "10197", + "type": "gene", + "text": "Human SRF - related proteins : DNA - binding properties and potential regulatory targets .", + "entities": [ + "SRF - related proteins" + ] + }, + { + "id": "10198", + "type": "gene", + "text": "These tumors were classified into three broad groups : I , cystadenoma ; II , cystadenocarcinoma ; and III , adenocarcinoma with mucin production or an associated cyst .", + "entities": [ + "mucin" + ] + }, + { + "id": "10199", + "type": "gene", + "text": "Stable transfection of the truncated reduced folate carrier cDNA into mouse L1210 leukemia cells : increased folate accumulation , decreased their leucovorin and folic acid growth requirements , and increased their sensitivity to methotrexate .", + "entities": [ + "reduced folate carrier cDNA" + ] + }, + { + "id": "10200", + "type": "gene", + "text": "The prophylactic use of new medication for patients between the first and second cycle of chemotherapy , in agreement with the estimates calculated , does not save health care costs but may improve the quality of life in these patients and permit the continuation of a therapeutic schedule without interruption which may improve the life expectancy of the patient .", + "entities": [] + }, + { + "id": "10201", + "type": "gene", + "text": "Extraction procedure for the measurement of butyltin compounds in biological tissues using toluene , HBr , and tropolone .", + "entities": [] + }, + { + "id": "10202", + "type": "gene", + "text": "These data demonstrate that DMVA does not cause more myocardial trauma than CPB when used to provide resuscitative circulatory support .", + "entities": [] + }, + { + "id": "10203", + "type": "gene", + "text": "Homologous recombination between the Autographa californica nuclear polyhedrosis virus ( AcNPV ) genome and a 0 . 6 - kbp - long DNA fragment derived from the putative DNA helicase gene of Bombyx mori nuclear polyhedrosis virus generates eh2 - AcNPV , an expanded - host - range AcNPV mutant ( S .", + "entities": [ + "DNA helicase gene of Bombyx mori nuclear polyhedrosis virus" + ] + }, + { + "id": "10204", + "type": "gene", + "text": "Regulation of laminin beta2 chain gene expression in human cancer cell lines .", + "entities": [ + "laminin beta2 chain gene" + ] + }, + { + "id": "10205", + "type": "gene", + "text": "Blood pressure in children .", + "entities": [] + }, + { + "id": "10206", + "type": "gene", + "text": "The consequences of intensive swine production on the environment and possible solutions by means of nutrition are outlined .", + "entities": [] + }, + { + "id": "10207", + "type": "gene", + "text": "Ovarian tumors in pregnancy .", + "entities": [] + }, + { + "id": "10208", + "type": "gene", + "text": "Molecular cloning , genomic mapping , and expression of two secretor blood group alpha ( 1 , 2 ) fucosyltransferase genes differentially regulated in mouse uterine epithelium and gastrointestinal tract .", + "entities": [ + "secretor blood group alpha ( 1 , 2 ) fucosyltransferase genes" + ] + }, + { + "id": "10209", + "type": "gene", + "text": "Within each lobe , the PA dispersion was up to 10 cmH2O at CFV of 90 l / min ; when flow decreased , PA at all sites decreased , as did the intralobar dispersion .", + "entities": [] + }, + { + "id": "10210", + "type": "gene", + "text": "Glutathione peroxidase in human red cells in health and disease .", + "entities": [ + "Glutathione peroxidase" + ] + }, + { + "id": "10211", + "type": "gene", + "text": "On the other hand , phosphatidyl inositol 4 , 5 bisphosphate ( PIP2 ) hydrolysis requires direct phosphorylation at tyrosine residue of the PLC - gamma1 isozyme .", + "entities": [ + "PLC - gamma1 isozyme" + ] + }, + { + "id": "10212", + "type": "gene", + "text": "The ability of U6 - U57 mutants to influence the fidelity of both branch site and 3 ' splice site recognition suggests that this nucleotide may participate in the formation of the active site ( s ) of the spliceosome .", + "entities": [ + "U6", + "U57" + ] + }, + { + "id": "10213", + "type": "gene", + "text": "One antibody , mAb1C2 , and a synthetic peptide comprising its epitope selectively inhibited in vitro transcription from TATA - containing , but not from TATA - less promoters , irrespective of whether they were transcribed by Pol II or Pol III .", + "entities": [ + "mAb1C2", + "Pol II", + "Pol III" + ] + }, + { + "id": "10214", + "type": "gene", + "text": "The nuclear proteins encoded by the c - fos and c - jun protooncogenes are expressed during the proliferation period of osteoblast phenotype development .", + "entities": [ + "c - fos", + "c - jun protooncogenes" + ] + }, + { + "id": "10215", + "type": "gene", + "text": "The cDNA of cpm7 encodes a closely related protein of 36 . 8 kDa .", + "entities": [ + "cpm7" + ] + }, + { + "id": "10216", + "type": "gene", + "text": "Studies carried out with the Glossina morsitans colony of Lisbon .", + "entities": [] + }, + { + "id": "10217", + "type": "gene", + "text": "Thus , CHOP not only is a negative or a positive regulator of C / EBP target genes but also , when tethered to AP - 1 factors , can activate AP - 1 target genes .", + "entities": [ + "CHOP", + "C / EBP", + "AP - 1 factors", + "AP - 1" + ] + }, + { + "id": "10218", + "type": "gene", + "text": "Inducible VT was suppressed entirely in one patient .", + "entities": [] + }, + { + "id": "10219", + "type": "gene", + "text": "In contrast to hemodynamic and histopathological predictors of survival , vWF : Ag does not require invasive techniques to be determined .", + "entities": [ + "vWF" + ] + }, + { + "id": "10220", + "type": "gene", + "text": "To study the retinal surface in the human eye in normal and diseased states we used laser scanning tomography .", + "entities": [] + }, + { + "id": "10221", + "type": "gene", + "text": "Nature 398 , 828 - 830 ) that the amino acid sequences of peptide fragments obtained from a polypeptide found in a complex of proteins that alters chromatin structure ( ARC ) are identical to portions of the deduced open reading frame of TIG - 1 mRNA .", + "entities": [ + "ARC", + "TIG - 1 mRNA" + ] + }, + { + "id": "10222", + "type": "gene", + "text": "The routine administration of fat - soluble vitamins appears unnecessary but it is prudent to measure prothrombin time and serum vitamins A and E at intervals .", + "entities": [ + "prothrombin" + ] + }, + { + "id": "10223", + "type": "gene", + "text": "Also , except in one patient who developed gallstones following institution of colestipol , saturation of gallbladder bile with cholesterol was not markedly increased by this drug alone .", + "entities": [] + }, + { + "id": "10224", + "type": "gene", + "text": "Because of concerns regarding blood transfusion - related communicable disease ( eg , acquired immune deficiency syndrome and non - A , non - B hepatitis ) , there has been increasing research effort into postoperative hemorrhage related to cardiopulmonary bypass with extracorporeal circulation .", + "entities": [] + }, + { + "id": "10225", + "type": "gene", + "text": "These defects no doubt impair the folding and configuration necessary for normal processing of the AVP gene precursor .", + "entities": [ + "AVP gene precursor" + ] + }, + { + "id": "10226", + "type": "gene", + "text": "4 Five patients died within one month of captopril and five between four and seven months , three of whom had improved to class IIM and one to IIS before death .", + "entities": [] + }, + { + "id": "10227", + "type": "gene", + "text": "It is likely that other pathways involve alternate signal transduction events ( e . g . , calcium mobilization ) and promoter response elements ( e . g . , SRE ) .", + "entities": [] + }, + { + "id": "10228", + "type": "gene", + "text": "The patients were divided into 4 groups receiving NLA II with or without nalorphine , morphine or Micoren .", + "entities": [] + }, + { + "id": "10229", + "type": "gene", + "text": "A single protease - resistant structure formed by the entirety of both PDZ repeats 1 and 2 ( PDZ1 - 2 ) contains the protein 4 . 1 - binding site .", + "entities": [ + "PDZ repeats 1 and 2", + "PDZ1 - 2", + "protein 4 . 1 - binding site" + ] + }, + { + "id": "10230", + "type": "gene", + "text": "High radial r values with small standard deviations were observed in normal LV ( 0 . 972 + / - 0 . 016 ) and in non - MI regions ( 0 . 964 + / - 0 . 018 ) , indicating temporally homogeneous radial shortening .", + "entities": [] + }, + { + "id": "10231", + "type": "gene", + "text": "These include NPF repeats , a leucine heptad repeat enriched in charged residues , and a proline - rich SH3 - like and / or WW domain - binding site in the N - terminal domain , which is followed by a membrane core containing four putative transmembrane spans and three amphiphilic segments that are the most highly conserved structural elements .", + "entities": [ + "SH3 - like" + ] + }, + { + "id": "10232", + "type": "gene", + "text": "Hypoxic ventilatory responses were - 1 . 99 + / - 0 . 37 L / min / % SaO2 in the relatives and - 1 . 54 + / - 0 . 25 L / min / % SaO2 in the control subjects . ( ABSTRACT TRUNCATED AT 250 WORDS )", + "entities": [] + }, + { + "id": "10233", + "type": "gene", + "text": "Molecular cloning of Elk - 3 , a new member of the Ets family expressed during mouse embryogenesis and analysis of its transcriptional repression activity .", + "entities": [ + "Elk - 3", + "Ets family" + ] + }, + { + "id": "10234", + "type": "gene", + "text": "Adhesion , phagocytosis , chemotactic and random migration , nitroblue tetrazolium dye reduction of peritoneal exudate neutrophils and macrophages , fibrinogen level , gelation of soluble fibrin and serial dilution protamine sulfate test were investigated in 115 New Zealand white rabbits with experimentally induced Shwartzman phenomenon in the colon , and in control animals .", + "entities": [ + "fibrinogen", + "fibrin" + ] + }, + { + "id": "10235", + "type": "gene", + "text": "We have previously identified mouse and human cDNAs encoding UNC - 51 - like kinase ( ULK1 ) .", + "entities": [ + "mouse and human cDNAs encoding UNC - 51 - like kinase", + "ULK1" + ] + }, + { + "id": "10236", + "type": "gene", + "text": "In vitro expression of four different naturally occurring nonsense and missense mutations revealed a dramatically altered subcellular location of the protein in cultured cells .", + "entities": [] + }, + { + "id": "10237", + "type": "gene", + "text": "Splice - junction elements and intronic sequences regulate alternative splicing of the Drosophila myosin heavy chain gene transcript .", + "entities": [ + "myosin heavy chain gene" + ] + }, + { + "id": "10238", + "type": "gene", + "text": "20 % of total HSL transcripts in human subcutaneous adipocytes .", + "entities": [ + "HSL transcripts" + ] + }, + { + "id": "10239", + "type": "gene", + "text": "Northern analysis revealed no detectable expression of the transcript in diapause - or nondiapause - programmed wandering larvae , and only trace expression in nondiapausing pupae .", + "entities": [] + }, + { + "id": "10240", + "type": "gene", + "text": "Decreased cardiac glycogen following phenformin injection in hyperglycemic , hyperinsulinemic anaesthetized rats .", + "entities": [] + }, + { + "id": "10241", + "type": "gene", + "text": "Failure of stapedius reflexometry in the diagnosis of myasthenia gravis .", + "entities": [] + }, + { + "id": "10242", + "type": "gene", + "text": "Human alpha - galactosidase A : nucleotide sequence of a cDNA clone encoding the mature enzyme .", + "entities": [ + "Human alpha - galactosidase A" + ] + }, + { + "id": "10243", + "type": "gene", + "text": "Furthermore , the 3 ' - untranslated regions of pmGT10 display a marked degree of homology to the 3 ' region of the rat Yb1 gene , while this region of pmGT2 displays marked homology to the corresponding region of the rat Yb2 gene .", + "entities": [ + "pmGT10", + "rat Yb1 gene", + "pmGT2", + "rat Yb2 gene" + ] + }, + { + "id": "10244", + "type": "gene", + "text": "Mutation analysis implicated multiple segments of the 5 ' untranslated region as contributing to the inhibitory effect .", + "entities": [] + }, + { + "id": "10245", + "type": "gene", + "text": "Downstream of the G - A anastomosis , the RD , CC , E ( p ) and loop areas were significantly different from REF , but significantly different from A - A .", + "entities": [] + }, + { + "id": "10246", + "type": "gene", + "text": "Movement programming depends on understanding of behavioral requirements .", + "entities": [] + }, + { + "id": "10247", + "type": "gene", + "text": "The investigation was apt at studying the relationship between urinary metabolites of serotonin and catecholamine ( 5 - HIAA and VMA ) , T - cells ( OKT3 + ) , T - helper ( OKT4 + ) , T - suppressor ( OKT8 + ) and B - cells ( EAC - rosette forming cells ) in normal ( 10 subjects , 1 female , 9 male , age 21 + / - 5 years ) and stress administered subjects ( 20 subjects , 3 female , 17 male , age 20 + / - 4 years ) .", + "entities": [ + "OKT3 +", + "OKT4 +", + "OKT8 +" + ] + }, + { + "id": "10248", + "type": "gene", + "text": "Competition EMSA established that constitutively expressed nuclear proteins bound the KCS element selectively ; KCS protein binding activity correlated with promoter activity in the transient transfection reporter assay .", + "entities": [ + "KCS element", + "KCS protein" + ] + }, + { + "id": "10249", + "type": "gene", + "text": "Based on this analysis , we propose that the interactions of Sos with the switch 1 and switch 2 regions of Ras have distinct functional consequences : the interaction with switch 2 mediates the anchoring of Ras to Sos , whereas the interaction with switch 1 leads to disruption of the nucleotide - binding site and GDP dissociation .", + "entities": [ + "Sos", + "Ras", + "Ras", + "Sos" + ] + }, + { + "id": "10250", + "type": "gene", + "text": "Effects of chronic descending tractotomy on the response patterns of neurons in the trigeminal nuclei principalis and oralis .", + "entities": [] + }, + { + "id": "10251", + "type": "gene", + "text": "While blood pressure and noradrenergic activity , assessed as changes in the plasma levels and urinary excretion of norepinephrine , remained unaffected in the Pl group , a significant drop in the supine systolic and diastolic blood pressures , as well as in the resting venous norepinephrine level and in urinary norepinephrine excretion was found after the first month of dF administration .", + "entities": [] + }, + { + "id": "10252", + "type": "gene", + "text": "Two XPG regions with putative NLS [ amino acid ( AA ) coordinates : NLS - B ( AA 1057 - 1074 ) and NLS - C ( AA 1171 - 1185 ) ] were each shown to independently localize the beta - gal extensively ( > 80 % ) to the nucleus of HeLa cells .", + "entities": [ + "XPG regions", + "beta - gal" + ] + }, + { + "id": "10253", + "type": "gene", + "text": "These results suggest that Rho1p regulates cytoskeletal reorganization at least through Bni1p and Pkc1p .", + "entities": [ + "Rho1p", + "Bni1p", + "Pkc1p" + ] + }, + { + "id": "10254", + "type": "gene", + "text": "Esophageal brush cytological screening was undertaken and blood concentrations of micronutrients ( vitamin A , E , B12 , folic acid and methionine ) determined from adults at risk for esophageal carcinoma ( EC ) in Transkei and Ciskei , Southern Africa .", + "entities": [] + }, + { + "id": "10255", + "type": "gene", + "text": "In addition , insulin induced AP - 1 DNA binding activity , this effect being totally prevented in the presence of MEK - 1 inhibitor .", + "entities": [ + "insulin", + "AP - 1", + "MEK - 1" + ] + }, + { + "id": "10256", + "type": "gene", + "text": "The latter was determined as follows : Type I - solid tumor tissue without significant peripheral isolated tumor cells ; Type II - solid tumor tissue associated with peripheral isolated tumor cells ; Type III - isolated tumor cells only .", + "entities": [] + }, + { + "id": "10257", + "type": "gene", + "text": "The relations between type A behavior , clinically relevant behavior , academic achievement , and IQ in children .", + "entities": [] + }, + { + "id": "10258", + "type": "gene", + "text": "Conclusion : The Lp ( a ) levels in these children were the lower ever reported .", + "entities": [ + "Lp ( a )" + ] + }, + { + "id": "10259", + "type": "gene", + "text": "Similar results were obtained with xylitol , an activator of the pentose phosphate pathway .", + "entities": [] + }, + { + "id": "10260", + "type": "gene", + "text": "On the other hand , neither phosphate buffered saline injection into the ES nor primary KLH challenges of the ES were capable of elevating the threshold level and changing the latency .", + "entities": [ + "KLH" + ] + }, + { + "id": "10261", + "type": "gene", + "text": "A 5 ' RNA stem - loop participates in the transcription attenuation mechanism that controls expression of the Bacillus subtilis trpEDCFBA operon .", + "entities": [ + "Bacillus subtilis trpEDCFBA operon" + ] + }, + { + "id": "10262", + "type": "gene", + "text": "The nm23 - H1 / nm23 - H2 gene transcriptional activity ratio varied depending on the cell line .", + "entities": [ + "nm23 - H1", + "nm23 - H2" + ] + }, + { + "id": "10263", + "type": "gene", + "text": "Structural basis for activation of human lymphocyte kinase Lck upon tyrosine phosphorylation .", + "entities": [ + "Lck" + ] + }, + { + "id": "10264", + "type": "gene", + "text": "Regulatory motifs for gene expression such as nuclear - factor - kappaB - binding - site - like sequence ( kappaB site ) and nuclear - factor - interleukin - 6 - binding - site - like sequence ( NF - IL - 6 site ) were found in the 5 ' - upstream regulatory region .", + "entities": [ + "nuclear - factor - kappaB - binding - site - like sequence", + "kappaB site", + "nuclear - factor - interleukin - 6 - binding - site - like sequence", + "NF - IL - 6 site" + ] + }, + { + "id": "10265", + "type": "gene", + "text": "Chimeric phage - plasmid expression vectors were constructed from pUC18 / 19 plasmids by cloning a single - stranded DNA ( ssDNA ) origin of replication from bacteriophage f1 and inserting a bacteriophage T7 promoter within the beta - galactosidase gene .", + "entities": [ + "beta - galactosidase gene" + ] + }, + { + "id": "10266", + "type": "gene", + "text": "Thus , it was confirmed that the sodium lauryl sulfate method of estimating hemoglobin concentration is an appropriate alternative to the cyanmethemoglobin method and avoids the generation of toxic wastes .", + "entities": [ + "hemoglobin", + "cyanmethemoglobin" + ] + }, + { + "id": "10267", + "type": "gene", + "text": "Among a population of 18 , 175 children below 7 years of age in medium sized towns and rural areas in south - western Germany 552 ( 3 . 03 % ) cases of croup were registered during a 12 months period in 1984 - 85 by their physicians .", + "entities": [] + }, + { + "id": "10268", + "type": "gene", + "text": "In vitro evaluation of the mucolytic action of urea .", + "entities": [] + }, + { + "id": "10269", + "type": "gene", + "text": "Evidence that therapeutic alterations of a circadian rhythm for gastric emptying response may be possible .", + "entities": [] + }, + { + "id": "10270", + "type": "gene", + "text": "i .", + "entities": [] + }, + { + "id": "10271", + "type": "gene", + "text": "It contained seven extra amino acids of FVVLNLQ ; this short stretch of extra sequence was found between Gln ( 421 ) and Phe ( 422 ) within the SET ( Suvar3 - 9 , Enhancer - of - zeste , Trithorax ) interacting domain ( SID ) of rMTM .", + "entities": [ + "SET", + "Suvar3 - 9", + "Enhancer - of - zeste", + "Trithorax", + "rMTM" + ] + }, + { + "id": "10272", + "type": "gene", + "text": "A high efficacy of the combined use of nontoxic doses of two pharmaceuticals : cystamine ( 50 mg / kg ) and mexamine ( 25 mg / kg ) under the conditions of short - term exogenous hypoxia ( 7 . 5 % O2 ) was found in ( CBA X C57Bl ) F1 mice .", + "entities": [] + }, + { + "id": "10273", + "type": "gene", + "text": "155 aa , shares 78 % identity with the analogous region of Xenopus laevis FGF3 and 72 % identity with the product of the more distantly related human gene .", + "entities": [ + "FGF3" + ] + }, + { + "id": "10274", + "type": "gene", + "text": "In a retrospective analysis of first - time total colonoscopies in 685 patients , we investigated the relationship between hyperplastic and adenomatous polyps .", + "entities": [] + }, + { + "id": "10275", + "type": "gene", + "text": "METHODS : Twenty - two patients were grouped according to their etiology based on the study of antiadrenal antibodies at diagnosis of the disease : 7 were positive ( autoimmune etiology or EAA ) , 11 were negative ( tuberculous etiology or EAT ) and in four serologic study was not available ( undetermined etiology or EAI ) .", + "entities": [] + }, + { + "id": "10276", + "type": "gene", + "text": "Taken together , we provide evidence for the existence of an activator , NFE , which in combination with the p50 and c - Rel proteins , are part of the transcription factor machinery that regulates 3 ' enhancer activity , and thus the control of the IgH locus in late B lymphocyte development .", + "entities": [ + "NFE", + "p50", + "c - Rel proteins", + "IgH locus" + ] + }, + { + "id": "10277", + "type": "gene", + "text": "As measured by the PDQ - 39 , STN - DBS significantly improves important aspects of QoL in patients with advanced PD .", + "entities": [] + }, + { + "id": "10278", + "type": "gene", + "text": "Functional analysis of DNase - I hypersensitive sites at the mouse porphobilinogen deaminase gene locus .", + "entities": [ + "DNase - I", + "mouse porphobilinogen deaminase gene locus" + ] + }, + { + "id": "10279", + "type": "gene", + "text": "Treatment of keratinocytes expressing a normal epidermal growth factor receptor ( EGFR ) with TGFalpha or epidermal growth factor for 5 min induced PKCdelta tyrosine phosphorylation .", + "entities": [ + "epidermal growth factor receptor", + "EGFR", + "TGFalpha", + "epidermal growth factor", + "PKCdelta" + ] + }, + { + "id": "10280", + "type": "gene", + "text": "Tranilast in the Therapy of Coronary Artery Disease .", + "entities": [] + }, + { + "id": "10281", + "type": "gene", + "text": "Oral supplementation of L - arginine significantly increased plasma L - citrulline , which indicated enhancement of NO production .", + "entities": [] + }, + { + "id": "10282", + "type": "gene", + "text": "The administration of the GnRH agonist reduced the bone mineral density in the whole femur to 91 . 0 % of that in the control group .", + "entities": [ + "GnRH" + ] + }, + { + "id": "10283", + "type": "gene", + "text": "Transcripts characterized include ( i ) abundant monocistronic L11e and tricistronic L1e - L10e - L12e transcripts ; ( ii ) less abundant bicistronic NAB - L11e and monocistronic NAB transcripts and ( iii ) a very rare ORF monocistronic transcript .", + "entities": [ + "L11e", + "L1e", + "L10e", + "L12e", + "NAB", + "L11e", + "NAB transcripts" + ] + }, + { + "id": "10284", + "type": "gene", + "text": "The nucleolin gene extends over 9000 base - pairs and is split into 14 exons that encode the 706 amino acid residues of the protein .", + "entities": [ + "nucleolin gene" + ] + }, + { + "id": "10285", + "type": "gene", + "text": "[ 18F ] ( + ) - 4 - fluorobenzyltrozamicol ( FBT ) , which selectively binds to the vesicular acetylcholine transporter in the presynaptic cholinergic neuron , has previously been shown to be a useful ligand for the study of cholinergic terminal density in the basal ganglia with PET .", + "entities": [ + "acetylcholine transporter" + ] + }, + { + "id": "10286", + "type": "gene", + "text": "On the basis of a global assessment patients showed a highly significant preference for imipramine compared with placebo as adjunctive therapy .", + "entities": [] + }, + { + "id": "10287", + "type": "gene", + "text": "Effects of 3 ' terminus modifications on mRNA functional decay during in vitro protein synthesis .", + "entities": [] + }, + { + "id": "10288", + "type": "gene", + "text": "We have explored the mechanism of action of the fibronectin splicing enhancer and found that the SE element is required for efficient assembly of early splicing complexes , allowing a more efficient interaction of the U2 snRNP with branch site sequences .", + "entities": [ + "fibronectin splicing enhancer", + "U2 snRNP" + ] + }, + { + "id": "10289", + "type": "gene", + "text": "The subunit protein of curli was highly homologous at its amino terminus to SEF - 17 , the subunit protein of thin , aggregative fimbriae of Salmonella enteritidis 27655 strain 3b , suggesting that these fibres form a novel class of surface organelles on enterobacteria .", + "entities": [ + "curli", + "SEF - 17" + ] + }, + { + "id": "10290", + "type": "gene", + "text": "Polyclonal antiserum generated to the fusion protein was capable of detecting 42 - and 46 - kilodalton polypeptides from virus particles ; both polypeptides were also shown to contain HBsAg determinants .", + "entities": [ + "HBsAg determinants" + ] + }, + { + "id": "10291", + "type": "gene", + "text": "A novel growth - related nuclear protein binds and inhibits rat aldolase B gene promoter .", + "entities": [ + "aldolase B gene" + ] + }, + { + "id": "10292", + "type": "gene", + "text": "All mutant JCV T antigens bound to JCV and SV40 origins of DNA replication .", + "entities": [ + "mutant JCV T antigens" + ] + }, + { + "id": "10293", + "type": "gene", + "text": "Nine cats received PMEA at a dosage of 10 mg / kg body weight , nine cats received FPMPA at a dosage of 25 mg / kg body weight .", + "entities": [] + }, + { + "id": "10294", + "type": "gene", + "text": "TNF - alpha induced a dose - and time - dependent increase in cyclooxygenase - 2 ( COX - 2 ) expression and PGE2 formation in human NCI - H292 epithelial cells .", + "entities": [ + "TNF - alpha", + "cyclooxygenase - 2", + "COX - 2" + ] + }, + { + "id": "10295", + "type": "gene", + "text": "Primer extension experiments revealed a strong transcription initiation site 102 bp upstream of the translational start site .", + "entities": [] + }, + { + "id": "10296", + "type": "gene", + "text": "Baseline BMD values were significantly lower in the oligo - amenorrheic group than in the two others at the level of lumbar spine ( anteroposterior view : 0 . 941 + / - 0 . 039 in oligo - amenorrheic vs 1 . 077 + / - 0 . 029 or 1 . 051 + / - 0 . 017 g x cm ( - 2 ) , P < 0 . 005 , in the eumenorrheic and contraceptive user groups , respectively ) but not in weight - bearing bone such as proximal and midshaft femur .", + "entities": [] + }, + { + "id": "10297", + "type": "gene", + "text": "In none of the 44 type I attacks and 29 type II attacks which were recorded did circulatory changes ; the latter were different in the two groups .", + "entities": [] + }, + { + "id": "10298", + "type": "gene", + "text": "Interestingly , this mutant cell line lacks expression of the IKK regulatory protein , IKKgamma .", + "entities": [ + "IKK regulatory protein", + "IKKgamma" + ] + }, + { + "id": "10299", + "type": "gene", + "text": "Drugs suppressed > or = 75 % of the total premature ventricular contractions in all patients who had both use - dependent QRS prolongation and reverse use - dependent QT prolongation , in 79 % of patients with use - dependent QRS prolongation alone , in 70 % with reverse use - dependent QT prolongation alone , and in 11 % with neither use - dependent QRS prolongation nor reverse use - dependent QT prolongation .", + "entities": [] + }, + { + "id": "10300", + "type": "gene", + "text": "The resulting clone pKB11 , which has a 1369 - base pair ( bp ) cDNA insert , overlapping pCAD142 by 781 bp , was identified by hybridization methods and sequence analysis and found to contain the entire cDNA sequence for the amino end of the CAD polypeptide .", + "entities": [ + "pKB11", + "pCAD142", + "CAD polypeptide" + ] + }, + { + "id": "10301", + "type": "gene", + "text": "Trinipatch is a small , transparent , matricial , monolayer patch with an absorption promoter , marketed in two dose - strengths ( 5 mg / 24 h and 10 mg / 24 h ) by Laboratoires Synthelabo .", + "entities": [] + }, + { + "id": "10302", + "type": "gene", + "text": "The signalling molecules Wnt1 and Sonic hedgehog , implicated in the activation of Myf5 in myogenic progenitor cells in the somite , are also produced in the viscinity of the Myf5 expression domain in the mesencephalon .", + "entities": [ + "Wnt1", + "Sonic hedgehog", + "Myf5", + "Myf5 expression domain" + ] + }, + { + "id": "10303", + "type": "gene", + "text": "SRF - deficient embryos ( Srf - / - ) have a severe gastrulation defect and do not develop to term .", + "entities": [ + "SRF", + "Srf" + ] + }, + { + "id": "10304", + "type": "gene", + "text": "The transcripts were equally active with or without a 5 ' methylated capstructure as expected , since EMCV - RNA is one of the mRNAs capable of internal initiation .", + "entities": [] + }, + { + "id": "10305", + "type": "gene", + "text": "In contrast , despite external radiation therapy , brain metastases proved fatal .", + "entities": [] + }, + { + "id": "10306", + "type": "gene", + "text": "From the National Institutes of Health .", + "entities": [] + }, + { + "id": "10307", + "type": "gene", + "text": "Interestingly , internal and 5 ' deletions revealed tha the distal promoter was not required for full transcriptional activity and that the first 631 base pairs of WNT - 5A harbored the strongest promoter activity .", + "entities": [ + "WNT - 5A" + ] + }, + { + "id": "10308", + "type": "gene", + "text": "RESULTS : We isolated a C . elegans cDNA that encoded a protein which was similar to , but not exactly homologous with mammalian p120 Ras - GAP .", + "entities": [ + "Ras", + "GAP" + ] + }, + { + "id": "10309", + "type": "gene", + "text": "After gamma - irradiation , the majority of F9 cells undergo apoptosis implying that wt - p53 likely triggers pro - apoptotic gene expression in DNA damaged cells .", + "entities": [ + "wt - p53" + ] + }, + { + "id": "10310", + "type": "gene", + "text": "Using avidin - biotin complex DNA binding assays , a series of overlapping alpha promoter DNA sequences between - 170 to 29 basepairs were tested , but each failed to bind GR , whereas a control GRE avidly bound receptor .", + "entities": [ + "avidin - biotin", + "alpha promoter DNA sequences", + "GR" + ] + }, + { + "id": "10311", + "type": "gene", + "text": "The recovery index ( T25 - T75 ) after the infusion stopped was similar in patients who received mivacurium and those who received suxamethonium .", + "entities": [] + }, + { + "id": "10312", + "type": "gene", + "text": "These clones overlapped and contained the structural gene encoding the complete C5 alpha - chain and 90 % of the beta - chain .", + "entities": [ + "C5 alpha - chain" + ] + }, + { + "id": "10313", + "type": "gene", + "text": "The ability of sodium phenobarbital ( 60 mg / kg ) and sodium barbital ( 80 mg / kg ) to produce a taste aversion in 23 hr fluid deprived rats was examined using a discrimination or two bottle taste aversion task ( 0 . 125 % sodium saccharin solution or water ) .", + "entities": [] + }, + { + "id": "10314", + "type": "gene", + "text": "Irmiere , and W .", + "entities": [] + }, + { + "id": "10315", + "type": "gene", + "text": "Management of postvitrectomy diabetic vitreous hemorrhage with tissue plasminogen activator ( t - PA ) and volume homeostatic fluid - fluid exchanger .", + "entities": [ + "tissue plasminogen activator", + "t - PA" + ] + }, + { + "id": "10316", + "type": "gene", + "text": "The mice are phenotypically normal and do not develop spontaneous tumors at an early age , in contrast to knock - out ( p53 ( - / - ) ) strains with a defective p53 gene .", + "entities": [ + "p53 ( - / - )", + "p53 gene" + ] + }, + { + "id": "10317", + "type": "gene", + "text": "Collectively , these results show that the differential utilization of Staf zinc finger 1 represents a new , critical determinant of the transcriptional activation mechanism for the Xenopus tRNA ( Sec ) and human U6 snRNA genes .", + "entities": [ + "Staf zinc finger 1", + "Xenopus tRNA", + "Sec", + "human U6 snRNA genes" + ] + }, + { + "id": "10318", + "type": "gene", + "text": "The so - called \" SH3 \" segment of the linker domain , in contrast , shows species - specific sequence identity in all but one amino acid residues in both factors , in cattle , human , and mouse .", + "entities": [ + "\" SH3 \" segment" + ] + }, + { + "id": "10319", + "type": "gene", + "text": "RESULTS : A significant correlation ( p < 0 . 001 ) was observed for mean wall thickness and vessel wall area between MRI and histopathology ( r = 0 . 87 and r = 0 . 85 , respectively ) .", + "entities": [] + }, + { + "id": "10320", + "type": "gene", + "text": "This hypothesis is consistent with the occurrence of PEA3 binding sites in the PEA3 promoter and with the ability of PEA3 to transactivate this promoter .", + "entities": [ + "PEA3 binding sites", + "PEA3 promoter", + "PEA3" + ] + }, + { + "id": "10321", + "type": "gene", + "text": "This study provides a direct demonstration of a role for G betagamma in mediating the agonist - stimulated translocation of GRK2 and GRK3 in an intact cellular system and demonstrates isoform specificity in the interaction of these components .", + "entities": [ + "G betagamma", + "GRK2", + "GRK3" + ] + }, + { + "id": "10322", + "type": "gene", + "text": "IgG levels of 1 / 100 were present in only four out of ten samples obtained 150 days after the clinical onset .", + "entities": [ + "IgG" + ] + }, + { + "id": "10323", + "type": "gene", + "text": "In the control preparation before weight was allowed to increase , isogravimetric capillary pressure ( Pci ) averaged 8 mmHg lower than colloid osmotic pressure of the plasma ( IIp ) .", + "entities": [] + }, + { + "id": "10324", + "type": "gene", + "text": "Thirty - five patients were included .", + "entities": [] + }, + { + "id": "10325", + "type": "gene", + "text": "Treatment with heparin , plasminogen activators and fibrinogenolytic agents was disappointing although renal function has stabilized in one patient on long term oral anticoagulant therapy .", + "entities": [ + "plasminogen" + ] + }, + { + "id": "10326", + "type": "gene", + "text": "The accumulation of both LHA4 and LHA2 mRNAs is induced by the addition of exogenous sugars and this induction appears to be dependent on sugar uptake and metabolism , because mannitol and 3 - O - methylglucose do not stimulate mRNA accumulation .", + "entities": [ + "LHA4", + "LHA2 mRNAs" + ] + }, + { + "id": "10327", + "type": "gene", + "text": "This promoter segment could drive expression of a luciferase reporter gene , could confer correct transcriptional initiation to the reporter and could confer the EGF - responsiveness previously observed in the native gene .", + "entities": [ + "luciferase reporter gene", + "EGF" + ] + }, + { + "id": "10328", + "type": "gene", + "text": "Even when the inoculum size was reduced sixfold ( i . e . , 6 x 10 ( 6 ) CFU / mouse ) , 50 % of the RB6 - 8C5 - treated animals died within 6 days .", + "entities": [ + "RB6 - 8C5" + ] + }, + { + "id": "10329", + "type": "gene", + "text": "The N - terminal sequence of one hydrophilic peptide of the FeS protein has been also obtained confirming the fbcF reading frame .", + "entities": [ + "FeS protein", + "fbcF" + ] + }, + { + "id": "10330", + "type": "gene", + "text": "This slope tended to be higher ( approximately 1 . 6 dB / dB ) for L1 = L2 greater than 80 dB .", + "entities": [] + }, + { + "id": "10331", + "type": "gene", + "text": "These sequences were then used to clone the full - length genes from a yeast genomic library .", + "entities": [] + }, + { + "id": "10332", + "type": "gene", + "text": "32Pi labeling or isoelectric focusing analysis of eIF - 2 alpha from conditional casein kinase II mutants indicated that phosphorylation of eIF - 2 alpha is abolished or dephosphorylated forms of eIF - 2 alpha are detected when these strains are grown at the restrictive growth conditions .", + "entities": [ + "eIF - 2 alpha", + "casein kinase II mutants", + "eIF - 2 alpha", + "eIF - 2 alpha" + ] + }, + { + "id": "10333", + "type": "gene", + "text": "We have been able to map specific DNA fragments at the bases of chromatin loops with the help of a novel extraction procedure by using lithium - 3 ' , 5 ' - diiodosalicylate .", + "entities": [] + }, + { + "id": "10334", + "type": "gene", + "text": "Cell lines derived from the tumors were examined by fluorescent in situ hybridization for the status of the transferred human chromosome and by PCR for marker loss .", + "entities": [] + }, + { + "id": "10335", + "type": "gene", + "text": "To evaluate the comparative safety of U - P and D & E , we analyzed 2 , 805 U - P and 9 , 572 D & E abortions at 13 to 24 menstrual weeks ' gestation .", + "entities": [] + }, + { + "id": "10336", + "type": "gene", + "text": "Biohydrogenation of linoleic acid into octadecenoic acid was observed .", + "entities": [] + }, + { + "id": "10337", + "type": "gene", + "text": "The loss of SKO1 completely restored ENA1 expression in a hog1 mutant and partially suppressed the osmotic stress sensitivity , qualifying Sko1p as a downstream effector of the HOG pathway .", + "entities": [ + "SKO1", + "ENA1", + "hog1 mutant", + "Sko1p", + "HOG" + ] + }, + { + "id": "10338", + "type": "gene", + "text": "Most importantly , the addition of purified 17S U2 snRNPs , but not of 12S U2 snRNPs , to HeLa splicing extracts in which the endogeneous U2 snRNPs have been functionally neutralized with anti - PRP9 antibodies fully restores the mRNA - splicing activity of the extracts .", + "entities": [ + "17S U2 snRNPs", + "12S U2 snRNPs", + "endogeneous U2 snRNPs", + "anti - PRP9 antibodies" + ] + }, + { + "id": "10339", + "type": "gene", + "text": "To investigate the regulation of expression of the human mdr1 gene , the response of the mdr1 promoter to signals involved in cell proliferation was examined .", + "entities": [ + "human mdr1 gene", + "mdr1 promoter" + ] + }, + { + "id": "10340", + "type": "gene", + "text": "By introducing a series of deletions in the vimentin promoter , we further restrict these sequences to 30 base pairs , located between 241 and 210 base pairs upstream of the mRNA cap site .", + "entities": [ + "vimentin" + ] + }, + { + "id": "10341", + "type": "gene", + "text": "We show that HRI and dsRNA - PK phosphorylate yeast eIF - 2 alpha in vitro and in vivo and functionally substitute for GCN2 protein to stimulate GCN4 translation in yeast .", + "entities": [ + "HRI", + "dsRNA - PK", + "yeast eIF - 2 alpha", + "GCN2 protein", + "GCN4" + ] + }, + { + "id": "10342", + "type": "gene", + "text": "A list of 12 names for the disease and 37 diagnostic criteria were proposed to a Consensus Panel of 12 Italian experts who ranked them in order so as to identify a core set of criteria .", + "entities": [] + }, + { + "id": "10343", + "type": "gene", + "text": "Nonreturn rates can be used to derive more elementary biological measures for reproductive efficiency , such as conception rate and calving rate , which separately might be more reliable than nonreturn rate itself to evaluate the fertility of a bull or the performance of an AI technician .", + "entities": [] + }, + { + "id": "10344", + "type": "gene", + "text": "Nuclear hormone receptors ( NRs ) are ligand - inducible transcription factors that mediate critical functions in many species .", + "entities": [] + }, + { + "id": "10345", + "type": "gene", + "text": "We measured serum hepatocyte growth factor ( HGF ) in patients with acute myocardial infarction , angina pectoris , and other heart diseases .", + "entities": [ + "serum hepatocyte growth factor", + "HGF" + ] + }, + { + "id": "10346", + "type": "gene", + "text": "The B - oligomer of pertussis toxin deactivates CC chemokine receptor 5 and blocks entry of M - tropic HIV - 1 strains .", + "entities": [ + "pertussis toxin", + "CC chemokine receptor 5" + ] + }, + { + "id": "10347", + "type": "gene", + "text": "This mutation also results in markedly decreased levels of CAD mRNA and protein in the mutant .", + "entities": [ + "CAD mRNA" + ] + }, + { + "id": "10348", + "type": "gene", + "text": "The effect of treatment may thus be divided into two main phases - - an initial phase with a reduction in LV mass and a reduction in cardiac output and no change in total peripheral resistance - - and a second phase with a constant LV mass but an increase in cardiac output to the pretreatment level again and a concomitant decrease in total peripheral resistance .", + "entities": [] + }, + { + "id": "10349", + "type": "gene", + "text": "Expression of SREBP - 1a stimulated StAR promoter activity in the context of COS - 1 cells and human granulosa - lutein cells .", + "entities": [ + "SREBP - 1a", + "StAR promoter" + ] + }, + { + "id": "10350", + "type": "gene", + "text": "A \" Level A \" in vitro / in vivo correlation was established for a sustained release theophylline ( CAS 58 - 55 - 9 ) preparation ( Bronchoretard ) under investigation .", + "entities": [] + }, + { + "id": "10351", + "type": "gene", + "text": "Serum prostatic acid phosphatase levels showed a significantly weaker correlation with cancer volume ( r equals 0 . 51 ) and every other pathological parameter .", + "entities": [ + "prostatic acid phosphatase" + ] + }, + { + "id": "10352", + "type": "gene", + "text": "Gel - shift assays identified two Sp1 binding sites within this element .", + "entities": [ + "Sp1 binding sites" + ] + }, + { + "id": "10353", + "type": "gene", + "text": "Neither clone encoded the cognate endonuclease .", + "entities": [] + }, + { + "id": "10354", + "type": "gene", + "text": "Tumours of the cavum oris and oropharynx of T1 - stage are possible only in 1 of 3 cases .", + "entities": [] + }, + { + "id": "10355", + "type": "gene", + "text": "Statement of the American Academy of Implant Dentistry .", + "entities": [] + }, + { + "id": "10356", + "type": "gene", + "text": "First , each lung was cut into slices , from which primary disectors were sampled systematically with a known sampling fraction .", + "entities": [] + }, + { + "id": "10357", + "type": "gene", + "text": "Diuretics : basic clinical pharmacology and therapeutic use .", + "entities": [] + }, + { + "id": "10358", + "type": "gene", + "text": "In marked contrast to AgfA , none of the chimeric SefA proteins were expressed or assembled into fimbriae .", + "entities": [ + "AgfA", + "chimeric SefA proteins" + ] + }, + { + "id": "10359", + "type": "gene", + "text": "This technique has a sensitivity and a specificity of almost 100 % , and is currently the best way to diagnose nodal involvement , apart from laparotomy .", + "entities": [] + }, + { + "id": "10360", + "type": "gene", + "text": "A large increase of serum ketones occurred under all conditions , and the exercise respiratory quotient suggested some increase of fat utilization , WW ( 0 . 85 ) through CW ( 0 . 84 ) to CC ( 0 . 83 ) .", + "entities": [] + }, + { + "id": "10361", + "type": "gene", + "text": "The survival rate at forty months in 15 patients with N2 disease who underwent R2b operation was 51 % .", + "entities": [] + }, + { + "id": "10362", + "type": "gene", + "text": "Lymphoproliferative disorders arising under immunosuppression with FK 506 : initial observations in a large transplant population .", + "entities": [] + }, + { + "id": "10363", + "type": "gene", + "text": "Among the transcription factors known to interact with Groucho - related protein , only RUNX1 was appreciably downregulated by E2A - HLF .", + "entities": [ + "Groucho - related protein", + "RUNX1", + "E2A", + "HLF" + ] + }, + { + "id": "10364", + "type": "gene", + "text": "A position - independent activation domain which contained conserved regions II and III was identified at the carboxyl terminus of the HNF - 3 beta protein ( amino acids 361 to 458 ) .", + "entities": [ + "HNF - 3 beta protein" + ] + }, + { + "id": "10365", + "type": "gene", + "text": "Five of these eight patients in group II also received 8 - in - 1 chemotherapy .", + "entities": [] + }, + { + "id": "10366", + "type": "gene", + "text": "The triple combination of nizatidine , clarithromycin , and bismuth subcitrate resulted in an ulcer healing rate of 98 % and an H . pylori eradication rate of 90 % .", + "entities": [] + }, + { + "id": "10367", + "type": "gene", + "text": "We characterized the structure of this leader mRNA by using the program Mfold and a combination of nested and internal deletions transcriptionally fused to a promoterless lac operon .", + "entities": [ + "lac operon" + ] + }, + { + "id": "10368", + "type": "gene", + "text": "No changes were evident in the FR - task performance of controls that received daily saline injections .", + "entities": [] + }, + { + "id": "10369", + "type": "gene", + "text": "The feed given to young broiler chickens was contaminated artificially with Salmonella kedougou , a serotype associated with both subclinical infections in commercially reared chickens and food poisoning in humans .", + "entities": [] + }, + { + "id": "10370", + "type": "gene", + "text": "The second transcript , rhis4l , is bicistronic .", + "entities": [ + "rhis4l" + ] + }, + { + "id": "10371", + "type": "gene", + "text": "The major pathological findings of the placenta were prematuration and hypoplasia .", + "entities": [] + }, + { + "id": "10372", + "type": "gene", + "text": "The UCR core sequence , CGCCATTTT , binds a ubiquitous nuclear factor and mediates negative regulation of MuLV promoter activity .", + "entities": [] + }, + { + "id": "10373", + "type": "gene", + "text": "We have cloned and sequenced a region encoding a lipase operon and a putative , previously uncharacterized metalloprotease of Vibrio cholerae O1 .", + "entities": [ + "lipase operon", + "metalloprotease of Vibrio cholerae O1" + ] + }, + { + "id": "10374", + "type": "gene", + "text": "Leukemia in twins : world - wide review of clinical cases .", + "entities": [] + }, + { + "id": "10375", + "type": "gene", + "text": "HANYS criticizes laparoscopic gall bladder guidelines .", + "entities": [] + }, + { + "id": "10376", + "type": "gene", + "text": "Three different techniques of EA analysis were used in the study : 1 ) fast Fourier transformation ( FFT ) of EA in a broad band , 2 ) developed by us alternative method of non - harmonic expansion of the EEG curves taking into account their shape , 3 ) factor analysis of the EA spectral densities .", + "entities": [] + }, + { + "id": "10377", + "type": "gene", + "text": "This up - grading of the final score by the CA component is greater ( 3 - 8 % ) in the less able students with scores below the mean level .", + "entities": [] + }, + { + "id": "10378", + "type": "gene", + "text": "This study allows us to draw conclusions about the identity of proteins required for the development of the nervous system in Drosophila and provides an example of a molecular approach to characterize en masse transposon - tagged mutations identified in genetic screens .", + "entities": [] + }, + { + "id": "10379", + "type": "gene", + "text": "15 , 2500 - 2508 ; O ' Neill , T .", + "entities": [] + }, + { + "id": "10380", + "type": "gene", + "text": "A retrospective study of banked sera from 19 cats with the eosinophilic granuloma complex revealed that 68 % of affected cats had circulating antibodies to components of normal cat epithelium .", + "entities": [] + }, + { + "id": "10381", + "type": "gene", + "text": "Local control rates were 91 % for metastatic lung cancer , 89 % for primary lung cancer and 85 % for T1 , 2N0M0 cases .", + "entities": [] + }, + { + "id": "10382", + "type": "gene", + "text": "In the premating period male rate of aggression was not significantly correlated with testosterone level .", + "entities": [] + }, + { + "id": "10383", + "type": "gene", + "text": "The synergistic effect due to the 5 ' - 3 ' cooperation was at least fourfold greater than the sum of the contributions of the individual UTRs .", + "entities": [] + }, + { + "id": "10384", + "type": "gene", + "text": "In mammalian cells , phosphorylation of eIF - 2 alpha inhibits the activity of eIF - 2B , the GDP - GTP exchange factor for eIF - 2 .", + "entities": [ + "eIF - 2 alpha", + "eIF - 2B", + "GDP - GTP exchange factor", + "eIF - 2" + ] + }, + { + "id": "10385", + "type": "gene", + "text": "Deletional analyses of VDR indicated that GRIP1 and RAC3 required an intact VDR activation function ( AF - 2 ) domain for efficient interaction as well as additional but distinct regions of the VDR .", + "entities": [ + "VDR", + "GRIP1", + "RAC3", + "VDR", + "VDR" + ] + }, + { + "id": "10386", + "type": "gene", + "text": "DNA sequence and evolution of the CPS domain of the Syrian hamster multifunctional protein CAD .", + "entities": [ + "CPS domain", + "Syrian hamster multifunctional protein CAD" + ] + }, + { + "id": "10387", + "type": "gene", + "text": "Experiments with recombinant proteins showed that p50 / p65 and high - mobility - group I ( Y ) protein cooperatively facilitated the binding of IRF - 1 to the VCAM1 IRF binding site and that IRF - 1 physically interacted with p50 and with high - mobility - group I ( Y ) protein .", + "entities": [ + "p50", + "p65", + "high - mobility - group I ( Y ) protein", + "IRF - 1", + "IRF binding site", + "IRF - 1", + "p50", + "high - mobility - group I ( Y ) protein" + ] + }, + { + "id": "10388", + "type": "gene", + "text": "Several nuclear factors that interact with sequences in the 5 ' flanking region of the mouse tyrosinase gene were identified using band shift and methylation interference assays .", + "entities": [ + "mouse tyrosinase gene" + ] + }, + { + "id": "10389", + "type": "gene", + "text": "Synthesis of ( + ) - lysergic acid diethylamide tartrate", + "entities": [] + }, + { + "id": "10390", + "type": "gene", + "text": "Key areas of the selection process including medical and surgical alternatives to transplantation , the composition of the transplant work - up , specific inclusion criteria as well as specific psychosocial factors and specific disease etiologies and co - morbidities that might represent contraindications were extensively reviewed .", + "entities": [] + }, + { + "id": "10391", + "type": "gene", + "text": "The majority of PI kinase activity appeared to be cbl - associated after PRL stimulation .", + "entities": [ + "PI kinase", + "cbl", + "PRL" + ] + }, + { + "id": "10392", + "type": "gene", + "text": "The results of the lab and field tests yielded high levels of infestation in larvae with values ranging from 90 to 100 % and from 85 to 95 % , respectively .", + "entities": [] + }, + { + "id": "10393", + "type": "gene", + "text": "Cultivation technics for Codonopsis pilosula", + "entities": [] + }, + { + "id": "10394", + "type": "gene", + "text": "Following iv injection of 0 . 5 g galactose per kg body weight , together with 2 mu Ci generally 14C - labelled galactose , 14CO2 is collected in regular intervals during one hour .", + "entities": [] + }, + { + "id": "10395", + "type": "gene", + "text": "Taken together , our data suggest that the antagonistic effects of CRP and KdgR on the expression of the pectinolysis genes occur by different mechanisms , including direct competition between the two regulators or between the repressor and RNA polymerase for the occupation of a common DNA region on the target genes .", + "entities": [ + "CRP", + "KdgR", + "pectinolysis genes", + "RNA polymerase" + ] + }, + { + "id": "10396", + "type": "gene", + "text": "At pH 6 . 9 , the same lidocaine concentrations significantly reduced resting potential ( 3 - 10 % ) , action potential amplitude ( 3 - 8 % ) and Vmax ( 14 - 22 % ) .", + "entities": [] + }, + { + "id": "10397", + "type": "gene", + "text": "In addition , 26 amino acid residues , K69 , D88 , E94 , D134 , R154 , K169 , H197 , D233 , G235 , G236 , G237 , F238 , E274 , G276 , R277 , Y278 , K294 , Y323 , Y331 , D332 , C360 , D361 , D364 , G387 , Y389 , and F397 ( mouse ODC numbering ) , all of which are implicated in the formation of the pyridoxal phosphate - binding domain and the substrate - binding domain and in dimer stabilization with the eukaryotic ODCs , were also conserved in S . ruminantium LDC .", + "entities": [ + "ODC", + "ODCs", + "LDC" + ] + }, + { + "id": "10398", + "type": "gene", + "text": "Chemical constituents of the gentianaceae V : tetraoxygenated xanthones of Swertia chirata Buch . - Ham .", + "entities": [] + }, + { + "id": "10399", + "type": "gene", + "text": "Thus adaptation to continuous mild stress has a potent antiarrhythmic effect which occurs due to the increased vagal tone .", + "entities": [] + }, + { + "id": "10400", + "type": "gene", + "text": "Specific and heritable genetic interference by double - stranded RNA in Arabidopsis thaliana .", + "entities": [] + }, + { + "id": "10401", + "type": "gene", + "text": "Slp1 represses transcription via this binding site in yeast cells , consistent with its role as a direct repressor of ftz stripes in interstripe regions during late stages of embryogenesis .", + "entities": [ + "Slp1", + "ftz" + ] + }, + { + "id": "10402", + "type": "gene", + "text": "Moreover , the observation of enhanced luteal HSP - 27 phosphorylation in vivo , in late pregnancy , when PKC - delta is abundant and active , suggests that select PKC family members contribute to sHSP phosphorylation events in vivo .", + "entities": [ + "luteal HSP - 27", + "PKC - delta", + "PKC family members", + "sHSP" + ] + }, + { + "id": "10403", + "type": "gene", + "text": "As PP2A exerts a range of cellular functions including cell cycle regulation and cell fate determination , we were surprised to find that these embryos develop normally until postimplantation , around embryonic day 5 . 5 / 6 . 0 .", + "entities": [ + "PP2A" + ] + }, + { + "id": "10404", + "type": "gene", + "text": "The mammalian homeodomain proteins encoded by Hox genes play an important role in embryonic development by providing positional queues which define developmental identities along the anteroposterior axis of developing organisms .", + "entities": [ + "mammalian homeodomain proteins", + "Hox genes" + ] + }, + { + "id": "10405", + "type": "gene", + "text": "Plasmid pAL618 contains the genetic determinants for H2 uptake ( hup ) from Rhizobium leguminosarum bv . viciae , including a cluster of 17 genes named hupSLCDEFGHIJK - hypABFCDE .", + "entities": [ + "hup", + "hupSLCDEFGHIJK - hypABFCDE" + ] + }, + { + "id": "10406", + "type": "gene", + "text": "Spatiotemporal expression of the PAX3 gene is tightly regulated during development .", + "entities": [ + "PAX3 gene" + ] + }, + { + "id": "10407", + "type": "gene", + "text": "Previous studies have suggested that the 616 amino acid , 70 - kDa subunit of RPA ( RPA 70 ) is composed of multiple structural / functional domains .", + "entities": [ + "70 - kDa subunit of RPA", + "RPA 70" + ] + }, + { + "id": "10408", + "type": "gene", + "text": "After screening the Berkeley Drosophila Genome Project database with sequences from a recently characterized Leu - rich repeats - containing G protein - coupled receptor ( LGR ) from Drosophila ( DLGR - 1 ) , we identified a second gene for a different LGR ( DLGR - 2 ) and cloned its cDNA .", + "entities": [ + "Leu - rich repeats - containing G protein - coupled receptor", + "LGR", + "DLGR - 1", + "LGR", + "DLGR - 2" + ] + }, + { + "id": "10409", + "type": "gene", + "text": "On parents", + "entities": [] + }, + { + "id": "10410", + "type": "gene", + "text": "Losses of dichlofluanid ( 54 % ) , chlozolinate ( 22 % ) , and etridiazole ( 40 % ) , previously reported to occur during ambient processing of apples , were reduced to barely significant levels ( 10 , 17 , and 14 % , respectively ) by cryogenic processing .", + "entities": [] + }, + { + "id": "10411", + "type": "gene", + "text": "Sequence analysis of reverse transcribed , amplified cDNA generated from total RNA isolated from transfected cells demonstrated the presence of abnormally spliced products containing 13 and 78 additional bases as well as the accumulation of unspliced mRNA .", + "entities": [] + }, + { + "id": "10412", + "type": "gene", + "text": "Detection of congenital hypothyroidism in 26 , 282 newborn infants", + "entities": [] + }, + { + "id": "10413", + "type": "gene", + "text": "Serotonin levels in infant hypothyroidism .", + "entities": [] + }, + { + "id": "10414", + "type": "gene", + "text": "This new knowledge has contributed to the development of a successful immunoprophylactic strategy for eliminating Hib disease .", + "entities": [] + }, + { + "id": "10415", + "type": "gene", + "text": "T . , Patel , S .", + "entities": [] + }, + { + "id": "10416", + "type": "gene", + "text": "Genetic and phenotypic analysis indicates that NHP6A and NHP6B function downstream of SLT2 .", + "entities": [ + "NHP6A", + "NHP6B", + "SLT2" + ] + }, + { + "id": "10417", + "type": "gene", + "text": "Northern blot and in situ hybridization analyses revealed GPR34 mRNA transcripts in several human and rat brain regions .", + "entities": [ + "GPR34 mRNA transcripts" + ] + }, + { + "id": "10418", + "type": "gene", + "text": "CM - ACO3 is expressed in flowers and is not induced by any of the stimuli tested .", + "entities": [ + "CM - ACO3" + ] + }, + { + "id": "10419", + "type": "gene", + "text": "The coexpression of full - length expression constructs for both DBP and hepatic leukemia factor resulted in a dramatic increase in activation mediated by the GAL4 - DBP fusion proteins , suggesting the involvement of a regulated coactivator in this process .", + "entities": [ + "DBP", + "hepatic leukemia factor", + "GAL4", + "DBP" + ] + }, + { + "id": "10420", + "type": "gene", + "text": "The amino acid sequence of the S . aureus peptide carrying the phosphoryl group was found to be Gln - Val - Val - Ser - Thr - Phe - Met - Gly - Asn - Gly - Leu - Ala - Ile - Pro - His - Gly - Thr - Asp - Asp .", + "entities": [] + }, + { + "id": "10421", + "type": "gene", + "text": "The volume fraction ( Vv ) and number / mm2 ( Na ) of all capillaries ( perfused and nonperfused ) in a given area of brain were determined after staining for alkaline phosphatase .", + "entities": [ + "alkaline phosphatase" + ] + }, + { + "id": "10422", + "type": "gene", + "text": "We investigated the smoking habits of relapsers 1 year after quitting in a smoking cessation trial using nicotine or placebo patches .", + "entities": [] + }, + { + "id": "10423", + "type": "gene", + "text": "Of the 21 quadrants positive in the controls , 17 were correlated with previously detected jaw pathoses .", + "entities": [] + }, + { + "id": "10424", + "type": "gene", + "text": "As well , further deletion of the promoter region to nucleotide - 110 , which contains only one SF - 1 binding site , still retained the ability to respond to exogenous SF - 1 .", + "entities": [ + "SF - 1 binding site", + "SF - 1" + ] + }, + { + "id": "10425", + "type": "gene", + "text": "We show here that these Jun / eb1 chimeras are potent transactivators of AP1 sites and that they can cooperate with c - Ha - Ras to induce foci .", + "entities": [ + "Jun", + "eb1", + "AP1 sites", + "c - Ha - Ras" + ] + }, + { + "id": "10426", + "type": "gene", + "text": "Calcitriol therapy was associated with a decrease in serum iPTH levels ( 701 + / - 103 . 9 vs .", + "entities": [ + "iPTH" + ] + }, + { + "id": "10427", + "type": "gene", + "text": "Workplace violence - - nurses at risk .", + "entities": [] + }, + { + "id": "10428", + "type": "gene", + "text": "Mammalian Ras GTPase - activating protein ( GAP ) , p120 Ras - GAP , has been implicated as both a downregulator and effector of Ras proteins , but its precise role in Ras - mediated signal transduction pathways is unclear .", + "entities": [ + "GTPase - activating protein", + "GAP", + "Ras", + "GAP", + "Ras proteins", + "Ras" + ] + }, + { + "id": "10429", + "type": "gene", + "text": "Mutation of the Sp1 element , which abolishes Sp1 binding , results in a 6 - 10 - fold reduction in reporter activity .", + "entities": [ + "Sp1 element", + "Sp1" + ] + }, + { + "id": "10430", + "type": "gene", + "text": "Posttranslational regulation of Ty1 retrotransposition by mitogen - activated protein kinase Fus3 .", + "entities": [ + "Ty1", + "mitogen - activated protein kinase Fus3" + ] + }, + { + "id": "10431", + "type": "gene", + "text": "Transforming growth factor - beta ( TGF - beta ) induced growth arrest of cells involves regulation of the activities of both D - and E - type cyclin kinase complexes thought to be mediated primarily by the regulation of p15 ( Ink4b ) and p27 ( Kip1 ) cyclin kinase inhibitors .", + "entities": [ + "Transforming growth factor - beta", + "TGF - beta", + "D - and E - type cyclin kinase complexes", + "p15", + "Ink4b", + "p27", + "Kip1" + ] + }, + { + "id": "10432", + "type": "gene", + "text": "Clinical value of the estimation of growth kinetics of primary ovarian cancer recurrences by CA125 doubling time", + "entities": [ + "CA125" + ] + }, + { + "id": "10433", + "type": "gene", + "text": "We compared the volume of the pulmonary extravascular , extracellular water space using sodium and sucrose indicators in 8 normal and 11 edematous rabbit lungs by steady - state techniques .", + "entities": [] + }, + { + "id": "10434", + "type": "gene", + "text": "Regulators responsible for the pervasive , nonsex - specific alternative pre - mRNA splicing characteristic of metazoans are almost entirely unknown or uncertain .", + "entities": [] + }, + { + "id": "10435", + "type": "gene", + "text": "Cell .", + "entities": [] + }, + { + "id": "10436", + "type": "gene", + "text": "The amino acid sequences of the yeast and mammalian mitochondrial targeting sequences are similar but less related than the mature polypeptides .", + "entities": [] + }, + { + "id": "10437", + "type": "gene", + "text": "In particular , unc - 86 encodes a POU - type homeodomain protein needed for the production of the touch cells , while mec - 3 encodes a LIM - type homeodomain protein needed for the differentiation of the touch cells .", + "entities": [ + "unc - 86", + "POU - type homeodomain protein", + "mec - 3", + "LIM - type homeodomain protein" + ] + }, + { + "id": "10438", + "type": "gene", + "text": "Identification of an enhancer and an alternative promoter in the first intron of the alpha - fetoprotein gene .", + "entities": [ + "alpha - fetoprotein gene" + ] + }, + { + "id": "10439", + "type": "gene", + "text": "The results of induced coexpression were also supported by rapid generation of FeLV recombinants when FeLV - C was used to infect the feline 3201B cell line that constitutively expresses high levels of endogenous FeLV - specific mRNAs .", + "entities": [] + }, + { + "id": "10440", + "type": "gene", + "text": "The homology to v - mil starts within the coding sequence of exon 1 and ends within the 3 ' untranslated region of exon 11 , 12 nucleotides downstream from the nonsense codon terminating the large open reading frame shared between c - mil and v - mil .", + "entities": [ + "v - mil", + "c - mil", + "v - mil" + ] + }, + { + "id": "10441", + "type": "gene", + "text": "For instance , a total SIP score of an individual patient of 28 . 3 % ( which is taken as an example , being the mean score in the study population ) should decrease by at least 9 . 26 % or approximately 13 items , before any improvement beyond reproducibility noise can be detected .", + "entities": [] + }, + { + "id": "10442", + "type": "gene", + "text": "Characterization of the human gene encoding cytokeratin 17 and its expression pattern .", + "entities": [ + "human gene encoding cytokeratin 17" + ] + }, + { + "id": "10443", + "type": "gene", + "text": "Such marked differences are found occasionally in the literature : heterophile antibodies against bovine gammaglobulin are regarded as responsible for the interference in the Sephadex system of RIST .", + "entities": [ + "bovine gammaglobulin" + ] + }, + { + "id": "10444", + "type": "gene", + "text": "Large differences between the groups were not observed in HA - synthesizing enzyme activity , but degradative enzyme activity was much higher in aspirin - induced asthma - related polyps than in other types of nasal polyps tested .", + "entities": [ + "HA - synthesizing enzyme" + ] + }, + { + "id": "10445", + "type": "gene", + "text": "However , in a multivariate analysis considering age , gender , and a previous history of cardiovascular diseases , female gender was not independently associated with death .", + "entities": [] + }, + { + "id": "10446", + "type": "gene", + "text": "In treated herds , cows more than 40 d postpartum with a corpus luteum received prostaglandin F2 alpha .", + "entities": [] + }, + { + "id": "10447", + "type": "gene", + "text": "The fusion proteins were tested by ELISA for reactivity with a panel of human anti - La sera in order to define the nature of the epitopes .", + "entities": [ + "human anti - La sera" + ] + }, + { + "id": "10448", + "type": "gene", + "text": "A recently reported new member of the Vav family proteins , Vav3 has been identified as a Ros receptor protein tyrosine kinase ( RPTK ) interacting protein by yeast two - hybrid screening .", + "entities": [ + "Vav family proteins", + "Vav3", + "receptor protein tyrosine kinase", + "RPTK" + ] + }, + { + "id": "10449", + "type": "gene", + "text": "Previous investigators have suggested that subretinal blood damages the retina in part because of its solid fibrin meshwork .", + "entities": [ + "fibrin" + ] + }, + { + "id": "10450", + "type": "gene", + "text": "The relationship between estrogenic properties of Tamoxifen and breast cancer management is discussed .", + "entities": [] + }, + { + "id": "10451", + "type": "gene", + "text": "It was argued that this arose from the possibility that the nature of blue collar jobs was physical , and that loss of myocardial tissue might be expected to more markedly interfere with their work efficiency ( on returning to work ) than it would the efficiency of the more sedentary jobs of white collar workers .", + "entities": [] + }, + { + "id": "10452", + "type": "gene", + "text": "Like the elicitors of the hypersensitive reaction ( HR ) produced by E . chrysanthemi ( HarpinEch ) and E . amylovora ( HarpinEa ) , the deduced 36 - kDa protein does not possess a typical signal sequence , but it contains a putative membrane - spanning domain .", + "entities": [] + }, + { + "id": "10453", + "type": "gene", + "text": "It was suggested that the absence of pronounced differences between conditions may have been due to the complexity of the task or the type of prompts employed .", + "entities": [] + }, + { + "id": "10454", + "type": "gene", + "text": "Integrated mapping analysis of the Werner syndrome region of chromosome 8 .", + "entities": [] + }, + { + "id": "10455", + "type": "gene", + "text": "The analysis of the structure of the sleep period as a whole reveals that with increasing of the age the delta - wave stage ( DS ) of the QS ( determined by defined polygraphic parameters ) increases , while the paradoxical phase of sleep ( PS ) decreases , this change being more pronounced during the first six months than during the second ones of the first year of the life .", + "entities": [] + }, + { + "id": "10456", + "type": "gene", + "text": "Constructs containing the full - length PfCPK cDNA have been expressed in Escherichia coli at a high level to generate a 60 - kDa recombinant protein .", + "entities": [ + "full - length PfCPK cDNA" + ] + }, + { + "id": "10457", + "type": "gene", + "text": "CONCLUSION : Sonographic angiography has a possible role in the detection of small nodules in patients with CRF .", + "entities": [] + }, + { + "id": "10458", + "type": "gene", + "text": "Regulation of myosin phosphatase activity involves changes in subunit interactions , although molecular mechanisms are not defined .", + "entities": [ + "myosin phosphatase" + ] + }, + { + "id": "10459", + "type": "gene", + "text": "Here we show in mouse fibroblasts stably transformed by v - Src that mRNA and protein levels of p21 ( WAF1 / CIP1 ) , cyclin D1 , and cyclin E are elevated .", + "entities": [ + "v - Src", + "p21", + "WAF1", + "CIP1", + "cyclin D1", + "cyclin E" + ] + }, + { + "id": "10460", + "type": "gene", + "text": "Infarct regional ejection fraction improved by 10 . 1 + / - 2 . 1 % between early and late studies when the infarct - related artery was patent and by 4 . 8 + / - 1 . 4 % if it was occluded ( p = 0 . 048 ) ; changes in global and noninfarct regional ejection fraction were similar irrespective of perfusion status .", + "entities": [] + }, + { + "id": "10461", + "type": "gene", + "text": "Immobilized dimers of N - cadherin - Fc chimera mimic cadherin - mediated cell contact formation : contribution of both outside - in and inside - out signals .", + "entities": [ + "N - cadherin", + "Fc" + ] + }, + { + "id": "10462", + "type": "gene", + "text": "Routine isotope cystography using 99M Tc sulfur colloid for detection and follow - up of vesico - ureteral reflux", + "entities": [] + }, + { + "id": "10463", + "type": "gene", + "text": "Prominent protein kinase cascades are those that activate mitogen - activated protein ( MAP ) kinases .", + "entities": [ + "mitogen - activated protein ( MAP ) kinases" + ] + }, + { + "id": "10464", + "type": "gene", + "text": "Recent investigations have detailed a selective dye release technique in which a pulse of laser light induces the release of a fluorescent dye from temperature - sensitive liposomes circulating in the retinal vasculature .", + "entities": [] + }, + { + "id": "10465", + "type": "gene", + "text": "PARTICIPANTS : Convenience sample of ambulatory outpatients with hereditary motor and sensory neuropathy , type I ( n = 9 ) , myotonic muscular dystrophy ( n = 10 ) , and able - bodied controls ( n = 11 ) .", + "entities": [] + }, + { + "id": "10466", + "type": "gene", + "text": "Adenylosuccinate synthetase ( IMP : L - aspartate ligase ( GDP ) , EC 6 . 3 . 4 . 4 ) plays an important role in purine biosynthesis catalyzing the GTP - dependent conversion of IMP to AMP .", + "entities": [ + "Adenylosuccinate synthetase", + "L - aspartate ligase", + "EC 6 . 3 . 4 . 4" + ] + }, + { + "id": "10467", + "type": "gene", + "text": "This was performed in a double blinded , randomized , placebo - controlled study .", + "entities": [] + }, + { + "id": "10468", + "type": "gene", + "text": "An association between hSIE and Stat - 3 after MHC - I ligation was directly demonstrated by precipitating Stat - 3 from nuclear extracts with biotinylated hSIE probe and avidin - coupled agarose .", + "entities": [ + "hSIE", + "Stat - 3", + "MHC - I", + "Stat - 3", + "hSIE", + "avidin" + ] + }, + { + "id": "10469", + "type": "gene", + "text": "Reviewing manuscripts : developing an efficient system .", + "entities": [] + }, + { + "id": "10470", + "type": "gene", + "text": "These clones were found to share a common domain encoded by p ( CA ) n repeats ; a simple sequence length polymorphism ( SSLP ) .", + "entities": [] + }, + { + "id": "10471", + "type": "gene", + "text": "Derivatives of boswellic acids .", + "entities": [] + }, + { + "id": "10472", + "type": "gene", + "text": "Cat proteins are tyrosine - phosphorylated when co - expressed in cells with the focal adhesion kinase Fak and Src .", + "entities": [ + "Cat proteins", + "Fak", + "Src" + ] + }, + { + "id": "10473", + "type": "gene", + "text": "The study made to define the ability of lipid A monoclonal antibodies to correct hemodynamic disturbances due to endotoxemia in dog experiments showed the efficacy of the antibodies administration .", + "entities": [ + "lipid A monoclonal antibodies" + ] + }, + { + "id": "10474", + "type": "gene", + "text": "Northern ( RNA ) blot analyses indicated that the cdh genes encoding the five subunits and an open reading frame ( ORF1 ) with unknown function are cotranscribed during growth on acetate .", + "entities": [ + "cdh genes" + ] + }, + { + "id": "10475", + "type": "gene", + "text": "A study was conducted of a human male who had inhaled a mixture of 241Am and Pu .", + "entities": [] + }, + { + "id": "10476", + "type": "gene", + "text": "In the present report , 66 hemochromatosis families yielding 151 hemochromatosis chromosomes and 182 normal chromosomes were RFLP - typed with a battery of probes , including two newly derived polymorphic markers from the 6 . 7 and HLA - F loci located 150 and 250 kb telomeric to HLA - A , respectively .", + "entities": [ + "HLA - F loci", + "HLA - A" + ] + }, + { + "id": "10477", + "type": "gene", + "text": "Thus , ZNF74 sublocalization in nuclear domains enriched in pre - mRNA maturating factors , its RNA binding activity , and its direct phosphodependent interaction with the pol IIo , a form of the RNA polymerase functionally associated with pre - mRNA processing , suggest a role for this member of the KRAB multifinger protein family in RNA processing .", + "entities": [ + "ZNF74", + "pol IIo", + "RNA polymerase", + "KRAB multifinger protein family" + ] + }, + { + "id": "10478", + "type": "gene", + "text": "The increase in number of terminal hairs , which are defined as hairs more than 60 microm in diameter , in the designated area ( 0 . 5 cm square = 0 . 25 cm2 area ) of the procyanidin B - 2 group subjects after the 6 - month trial was significantly greater than that of the placebo control group subjects ( procyanidin B - 2 , 1 . 99 + / - 2 . 58 ( mean + / - SD ) / 0 . 25 cm2 ; placebo , - 0 . 82 + / - 3 . 40 ( mean + / - SD ) / 0 . 25 cm2 ; P < 0 . 02 , two - sample t test ) .", + "entities": [] + }, + { + "id": "10479", + "type": "gene", + "text": "The occurrence , maintenance and possible involvement of these repeated sequences , capable of forming stable secondary structures , are discussed in relation to their location in the region of control signals .", + "entities": [] + }, + { + "id": "10480", + "type": "gene", + "text": "Far - infrared hopping conductivity in the CuO chains of a single - domain YBa2Cu3O7 - delta crystal .", + "entities": [] + }, + { + "id": "10481", + "type": "gene", + "text": "Acylation with the palmitate analog was prevented when Gly - 2 was mutated to alanine , implying that N - myristylation is required for palmitylation , and when either Cys - 3 or Cys - 6 was mutated to serine .", + "entities": [] + }, + { + "id": "10482", + "type": "gene", + "text": "Mothers with severe anatomical abnormalities , who are HIV positive , have active TB or whose children have inherited mono - or disaccharide intolerances should not breastfeed .", + "entities": [] + }, + { + "id": "10483", + "type": "gene", + "text": "As in mammals , considerable nucleotide diversity was observed at the junctions of the variable , diversity , and joining elements in chicken TCR beta cDNAs .", + "entities": [ + "chicken TCR beta cDNAs" + ] + }, + { + "id": "10484", + "type": "gene", + "text": "ARPIA has been implemented by using a relational DBMS , very cheap and highly diffused on personal computers .", + "entities": [] + }, + { + "id": "10485", + "type": "gene", + "text": "Copyright 2001 Academic Press .", + "entities": [] + }, + { + "id": "10486", + "type": "gene", + "text": "Most important , infection of the cells with an adenoviral construct expressing this mutant inhibited the induction of VEGF mRNA under conditions that mimic hypoxia .", + "entities": [ + "VEGF mRNA" + ] + }, + { + "id": "10487", + "type": "gene", + "text": "A rise of hemoglobin concentration accompanied by an increase of the total iron in the blood serum of white mice was found under oxygen pressure of 4 atm for an hour ( preconvulsive state ) and 6 atm ( convulsive state ) .", + "entities": [ + "hemoglobin" + ] + }, + { + "id": "10488", + "type": "gene", + "text": "A significant association between a family history and a higher urinary pH was observed among the female calcium stone patients .", + "entities": [] + }, + { + "id": "10489", + "type": "gene", + "text": "However , most produced significant alteration of small intestinal permeability .", + "entities": [] + }, + { + "id": "10490", + "type": "gene", + "text": "Effects of point defects on lattice parameters of semiconductors .", + "entities": [] + }, + { + "id": "10491", + "type": "gene", + "text": "The NF1 locus encodes a protein functionally related to mammalian GAP and yeast IRA proteins .", + "entities": [ + "NF1 locus", + "mammalian GAP", + "yeast IRA proteins" + ] + }, + { + "id": "10492", + "type": "gene", + "text": "I .", + "entities": [] + }, + { + "id": "10493", + "type": "gene", + "text": "Repression is alleviated when the two ( for E2 ) or three ( for E2 - C ) promoter - proximal copies of E2 - RS are mutated .", + "entities": [ + "E2", + "E2 - C", + "E2" + ] + }, + { + "id": "10494", + "type": "gene", + "text": "Prenatal diagnosis of galactosaemia .", + "entities": [] + }, + { + "id": "10495", + "type": "gene", + "text": "The genomic structure and chromosomal location of the human TR2 orphan receptor , a member of the steroid receptor superfamily .", + "entities": [ + "human TR2 orphan receptor", + "steroid receptor superfamily" + ] + }, + { + "id": "10496", + "type": "gene", + "text": "Other adverse events with incidences significantly higher than with placebo were dizziness , constipation , sweating , nervousness , and abnormal ejaculation .", + "entities": [] + }, + { + "id": "10497", + "type": "gene", + "text": "The Jem peptide sequence shows a ' leucine - zipper ' dimerisation motif with limited homology to Fos / Jun and ATF / CREB proteins and several putative phosphorylation sites .", + "entities": [ + "Jem", + "Fos", + "Jun", + "ATF", + "CREB" + ] + }, + { + "id": "10498", + "type": "gene", + "text": "Thirty - two rats were divided into four groups .", + "entities": [] + }, + { + "id": "10499", + "type": "gene", + "text": "Skin pH changes associated with iontophoresis .", + "entities": [] + }, + { + "id": "10500", + "type": "gene", + "text": "An evolutionary comparison of amino acid sequences of 34 HSP70 proteins from 17 species suggests that BiP genes share a common ancestor , which diverged from other HSP70 genes near the time when eukaryotes first appeared .", + "entities": [ + "HSP70 proteins", + "BiP genes", + "HSP70 genes" + ] + }, + { + "id": "10501", + "type": "gene", + "text": "In Salmo gairdneri , no specialized system of portal vessels appears to exist between the pineal organ and other portions of the brain .", + "entities": [] + }, + { + "id": "10502", + "type": "gene", + "text": "The lethal toxicity of inorganic ( HgCl2 ) and organic ( CH3HgCl ) mercury chloride was compared for Coturnix ( Japanese quail , Coturnix japonica ) of different ages from hatch through adulthood by single - dose acute oral and intramuscular injections and by a 5 - d dietary trial .", + "entities": [] + }, + { + "id": "10503", + "type": "gene", + "text": "Binding of NusA to RNA in the presence of alpha or N involves an amino - terminal S1 homology region that is otherwise inactive in full - length NusA .", + "entities": [ + "NusA", + "amino - terminal S1 homology region", + "full - length NusA" + ] + }, + { + "id": "10504", + "type": "gene", + "text": "Insertion of 4 bp reduced SV40 early promoter - dependent chloramphenicol acetyltransferase ( CAT ) expression by six - to eightfold .", + "entities": [ + "SV40 early promoter", + "chloramphenicol acetyltransferase", + "CAT" + ] + }, + { + "id": "10505", + "type": "gene", + "text": "Since sildenafil came on the market , it seems that the place of MUSE is reduced because comparative studies give better results for sildenafil than MUSE ( 70 % vs 40 % ) and of course with a better acceptance .", + "entities": [] + }, + { + "id": "10506", + "type": "gene", + "text": "Both examinations are sensitive indicators of CNS abnormalities associated with bacterial meningeal infections and are important determinants of the therapy and ultimate prognosis of such complications .", + "entities": [] + }, + { + "id": "10507", + "type": "gene", + "text": "Imaging of D2 dopamine receptor", + "entities": [] + }, + { + "id": "10508", + "type": "gene", + "text": "Its potential as a diagnostic tool for epidemiological surveillance was assessed in comparison with three other diagnostic tests : stool examination , ELISA with soluble egg antigen ( SEA ) and the circumoval precipitin test ( COPT ) .", + "entities": [ + "soluble egg antigen", + "SEA", + "precipitin" + ] + }, + { + "id": "10509", + "type": "gene", + "text": "Combining multiple laboratory studies may be of value in predetermining the eventual outcome in near - drowning .", + "entities": [] + }, + { + "id": "10510", + "type": "gene", + "text": "Plane wave geometry is impractical for clinical use but the results of this work encouraged us to further develop the P3 approximation for a spherical geometry , described in this paper .", + "entities": [] + }, + { + "id": "10511", + "type": "gene", + "text": "Hence temperature and virF are both required for the induction of the yop regulon .", + "entities": [ + "virF", + "yop regulon" + ] + }, + { + "id": "10512", + "type": "gene", + "text": "Human thymine - DNA glycosylase maps at chromosome 12q22 - q24 . 1 : a region of high loss of heterozygosity in gastric cancer .", + "entities": [ + "Human thymine - DNA glycosylase" + ] + }, + { + "id": "10513", + "type": "gene", + "text": "The second functional pair of CreA sites is located between the two transcription initiation sites .", + "entities": [ + "CreA sites" + ] + }, + { + "id": "10514", + "type": "gene", + "text": "Members of SVA are also present in the complement C2 gene located about 20 kilobases upstream of RP1 in the HLA and in the cytochrome CYP1A1 gene .", + "entities": [ + "SVA", + "complement C2 gene", + "RP1", + "HLA", + "cytochrome CYP1A1 gene" + ] + }, + { + "id": "10515", + "type": "gene", + "text": "In this study , we have cloned the human DSG3 gene and examined the transcriptional regulation of its expression .", + "entities": [ + "human DSG3 gene" + ] + }, + { + "id": "10516", + "type": "gene", + "text": "In untreated mice , bactericidal activity of peritoneal macrophages decreased from one day to 3 days after ip injection of killed L . monocytogenes .", + "entities": [] + }, + { + "id": "10517", + "type": "gene", + "text": "Within the 3 ' terminal 50 nucleotides , the mouse mt 12S rRNA contains a potential 10 bp hairpin structure and a sequence of 15 consecutive nucleotides common to the RNA of the small ribosomal subunit in all systems , but does not contain the mRNA binding site ( ACCUCC ) found in E . coli and corn chloroplast rRNAs .", + "entities": [ + "mouse mt 12S rRNA" + ] + }, + { + "id": "10518", + "type": "gene", + "text": "Rapid detection of radioisotopically contaminated test serum before radioassay of vitamin B12 .", + "entities": [] + }, + { + "id": "10519", + "type": "gene", + "text": "Perfusion washout : increasing a microvascular free flap tolerance to ischemia .", + "entities": [] + }, + { + "id": "10520", + "type": "gene", + "text": "Disruption of the IRA2 gene resulted in ( i ) increased sensitivity to heat shock and nitrogen starvation , ( ii ) sporulation defects , and ( iii ) suppression of the lethality of the cdc25 mutant .", + "entities": [ + "IRA2 gene", + "cdc25 mutant" + ] + }, + { + "id": "10521", + "type": "gene", + "text": "Campomelic dysplasia translocation breakpoints are scattered over 1 Mb proximal to SOX9 : evidence for an extended control region .", + "entities": [ + "SOX9" + ] + }, + { + "id": "10522", + "type": "gene", + "text": "All were experienced hearing aid users who wore linear Class D instruments with input compression limiting at the time of their enrollment in this study .", + "entities": [] + }, + { + "id": "10523", + "type": "gene", + "text": "Computerized detection of abnormal asymmetry in digital chest radiographs .", + "entities": [] + }, + { + "id": "10524", + "type": "gene", + "text": "CONCLUSION : This study documents that regression of choroidal neovascularization that occurred with alpha interferon treatment was minimal .", + "entities": [ + "alpha interferon" + ] + }, + { + "id": "10525", + "type": "gene", + "text": "We argue that the primary role of hh in controlling polarity is to cause anterior compartment cells to reverse their interpretation of an underlying symmetric polarization .", + "entities": [ + "hh" + ] + }, + { + "id": "10526", + "type": "gene", + "text": "Reproducing populations of this aphid were first detected in Puerto Rico in April 1992 .", + "entities": [] + }, + { + "id": "10527", + "type": "gene", + "text": "The effectiveness of alpha - mercapto - beta - ( 2 - furyl ) acrylic acid ( MFA ) and N - benzyl - N - dithiocarboxy - D - glucamine ( NaB ) , used in combination , in the mobilization and excretion of lead was investigated in rats .", + "entities": [] + }, + { + "id": "10528", + "type": "gene", + "text": "Indeed the predicted folding of the 5 ' and 3 ' - untranslated regions revealed patterns of stem and loop structures conserved for all tick - borne flaviviruses suggesting a purifying selection for preservation of essential RNA secondary structures which could be involved in translational control and replication .", + "entities": [] + }, + { + "id": "10529", + "type": "gene", + "text": "Since electrical stimulation of neurones may activate not only cell bodies but also neuronal fibres , this study aimed to test a selectively cholinergic neurochemical stimulation of the rat substantia innominata ( SI ) by the local microinjection of carbachol ; the effects of this acetylcholine agonist were compared with glutamate .", + "entities": [] + }, + { + "id": "10530", + "type": "gene", + "text": "The humanized LL2 ( hLL2 ) , lacking light chain variable region glycosylation , exhibited immunoreactivities that were comparable to that of chimeric LL2 ( cLL2 ) , which was shown previously to have antigen - binding properties similar to its murine counterpart , suggesting that the VK - appended oligosaccharides found in mLL2 are not necessary for antigen binding .", + "entities": [ + "humanized LL2", + "hLL2", + "light chain variable region", + "chimeric LL2", + "cLL2", + "mLL2" + ] + }, + { + "id": "10531", + "type": "gene", + "text": "These bacteria produce and export proteins capable of specific interactions with key mammalian cell regulatory molecules in order to derail the normal functions of the cells .", + "entities": [] + }, + { + "id": "10532", + "type": "gene", + "text": "They were almost regularly excited by pressure to the ipsilateral cornea or to both corneas at a strength well above the human corneal pain threshold .", + "entities": [] + }, + { + "id": "10533", + "type": "gene", + "text": "The MMPI - A ( Butcher et al . , 1992 ) , like the older MMPI ( Hathaway & McKinley , 1983 ) , distinguishes between anorexia and bulimia .", + "entities": [] + }, + { + "id": "10534", + "type": "gene", + "text": "Glucose disappearance rate and changes in plasma nutrients after intravenouly injected glucose in normoglycaemic and hypoglycaemic underweight newborns .", + "entities": [] + }, + { + "id": "10535", + "type": "gene", + "text": "Magnetic trapping of spin - polarized atomic hydrogen .", + "entities": [] + }, + { + "id": "10536", + "type": "gene", + "text": "Therefore , a prospective Phase II trial was conducted to determine the safety and efficacy of cryosurgery following radiation therapy in men with local recurrence .", + "entities": [] + }, + { + "id": "10537", + "type": "gene", + "text": "RESULTS : In this group of patients , male gender ( P = 0 .", + "entities": [] + }, + { + "id": "10538", + "type": "gene", + "text": "Purified Pra was also shown to physically interact with pyruvate kinase ( Pk ) ; Pk and Pra can form a complex , but when the 12 - kDa Ndk , Pk , and Pra are all present , Pk has a higher affinity than Pra for forming a complex with the 12 - kDa Ndk .", + "entities": [ + "Purified Pra", + "pyruvate kinase", + "Pk", + "Pk", + "Pra", + "12 - kDa Ndk", + "Pk", + "Pra", + "Pk", + "Pra", + "12 - kDa Ndk" + ] + }, + { + "id": "10539", + "type": "gene", + "text": "Plasma lecithin / cholesterol acyltransferase ( LCAT ) activity in multiple - organ donors : a predictor of allograft viability in clinical liver transplantation .", + "entities": [ + "lecithin / cholesterol acyltransferase", + "LCAT" + ] + }, + { + "id": "10540", + "type": "gene", + "text": "Motivational factors focusing on attitudes , perceived susceptibility to pregnancy , and normative factors were also relevant .", + "entities": [] + }, + { + "id": "10541", + "type": "gene", + "text": "Morphometrical quantification of brain edema related to experimental multiple micro - infarcts in mice : assessment of neurotropin effect .", + "entities": [ + "neurotropin" + ] + }, + { + "id": "10542", + "type": "gene", + "text": "Ectopic expression of Apo - 3 in HEK293 or HeLa cells induced marked apoptosis .", + "entities": [ + "Apo - 3" + ] + }, + { + "id": "10543", + "type": "gene", + "text": "Analysis of the upstream untranslated region of CHL15 revealed the presence of the hexamer element , ACGCGT ( an MluI restriction site ) controlling both the periodic expression and coordinate regulation of the DNA synthesis genes in budding yeast .", + "entities": [ + "CHL15", + "MluI restriction site" + ] + }, + { + "id": "10544", + "type": "gene", + "text": "Some of these targets were reported to code for molecules involved in cell - cell interactions , whereas no relationship has yet been demonstrated between Hox genes and other transcription factors involved in determining and / or maintaining tissue specificity .", + "entities": [ + "Hox genes" + ] + }, + { + "id": "10545", + "type": "gene", + "text": "The relative R - and L - brain weights were found to be inversely related to the relative R - L brain weight only in the RH female cats with R - L brain weight smaller than zero ( testosterone in males , estrogen in females ) .", + "entities": [] + }, + { + "id": "10546", + "type": "gene", + "text": "However , whether or not nonsense codon recognition within TPI transcripts takes place prior to or after splicing remained unresolved .", + "entities": [ + "TPI transcripts" + ] + }, + { + "id": "10547", + "type": "gene", + "text": "In the stable transfectants ( BM3 cells ) expressing a mutant bacterial P450 AA epoxygenase , F87V BM3 , which was genetically engineered to metabolize arachidonic acid only to 14 , 15 - EET , AA did not induce apoptosis and protected against agonist - induced apoptosis .", + "entities": [ + "mutant bacterial P450 AA epoxygenase" + ] + }, + { + "id": "10548", + "type": "gene", + "text": "RESULTS : In the pregnant group , serum PP14 concentrations were markedly increased after ET , and a significant difference between the pregnant group and the nonpregnant group was observed 8 days following ET ( p < 0 . 01 ) .", + "entities": [ + "PP14" + ] + }, + { + "id": "10549", + "type": "gene", + "text": "Hepatitis C virus infection and lymphoproliferative diseases in France : a national study .", + "entities": [] + }, + { + "id": "10550", + "type": "gene", + "text": "Activation of nuclear factor ( NF ) - kappaB and subsequent proinflammatory gene expression in human airway epithelial cells can be evoked by oxidative stress .", + "entities": [ + "nuclear factor ( NF ) - kappaB" + ] + }, + { + "id": "10551", + "type": "gene", + "text": "Steroid glucuronides in amniotic fluid at term .", + "entities": [] + }, + { + "id": "10552", + "type": "gene", + "text": "Preimmune IgG , anti - GalT Fab fragments , irrelevant polymers and monomeric N - acetylglucosamine had no effect .", + "entities": [ + "Preimmune IgG", + "anti - GalT Fab fragments" + ] + }, + { + "id": "10553", + "type": "gene", + "text": "Equine amnion and live yeast cell derivative were evaluated as a biological dressing and as a topical wound medicament respectively , in the treatment of granulating wounds of the distal portion of the limbs of horses .", + "entities": [] + }, + { + "id": "10554", + "type": "gene", + "text": "These TxRE contain cyclic AMP - responsive elements ( CRE ) , but , remarkably , the \" TGACGTCA \" consensus is never strictly conserved in any viral strain ( e . g . , AGACGTCA , TGACGGCA , TGACCTCA ) .", + "entities": [ + "TxRE" + ] + }, + { + "id": "10555", + "type": "gene", + "text": "From the above results , we might infer that the seizure type of TLE and a high frequency of seizure are two major independent precipitate factors for abnormal latencies of P300 in the epileptic patients .", + "entities": [] + }, + { + "id": "10556", + "type": "gene", + "text": "We show that these three gain - of - function mutants differ considerably in their ability to bypass the sex determination signal , with SxlM4 being the strongest and SxlM1 the weakest .", + "entities": [ + "SxlM4", + "SxlM1" + ] + }, + { + "id": "10557", + "type": "gene", + "text": "We show that these three gain - of - function mutants differ considerably in their ability to bypass the sex determination signal , with SxlM4 being the strongest and SxlM1 the weakest .", + "entities": [ + "SxlM4", + "SxlM1" + ] + }, + { + "id": "10558", + "type": "gene", + "text": "Medicare SNF benefits revised - - again .", + "entities": [] + }, + { + "id": "10559", + "type": "gene", + "text": "Comparative analysis with an antiandrogen niftolid and synthetic GnRH was carried out in 22 normal subjects , 14 patients with primary and 20 ones with secondary hypogonadism , and in 5 patients with clinical signs of gonadal insufficiency and obscure diagnosis in order to elucidate the pituitary gonadotropin reserves .", + "entities": [ + "synthetic GnRH", + "pituitary gonadotropin" + ] + }, + { + "id": "10560", + "type": "gene", + "text": "Mutations at two neighboring sites , serine 242 and threonine 255 , exacerbated the effect .", + "entities": [] + }, + { + "id": "10561", + "type": "gene", + "text": "The relative abundance of each alternatively spliced mRNA was determined by reverse transcription - polymerase chain reaction in various human tissues and cell lines .", + "entities": [] + }, + { + "id": "10562", + "type": "gene", + "text": "Eastern Cooperative Oncology Group trial E3186 was initiated to explore this question .", + "entities": [] + }, + { + "id": "10563", + "type": "gene", + "text": "Cat - 1 is identical to the recently identified binding partner for the beta - adrenergic receptor kinase ( betaARK or GRK - 2 ) , which was shown to have Arf - GAP activity .", + "entities": [ + "Cat - 1", + "beta - adrenergic receptor kinase", + "betaARK", + "GRK - 2", + "Arf", + "GAP" + ] + }, + { + "id": "10564", + "type": "gene", + "text": "Examples of its use in the intensive therapy unit are described .", + "entities": [] + }, + { + "id": "10565", + "type": "gene", + "text": "Rat kidney carboxylesterase .", + "entities": [ + "Rat kidney carboxylesterase" + ] + }, + { + "id": "10566", + "type": "gene", + "text": "The Klebsiella aerogenes gene maoA , which is involved in the synthesis of monoamine oxidase , was induced by tyramine and the related compounds , subjected to catabolite and ammonium ion repression , and cloned .", + "entities": [ + "Klebsiella aerogenes gene maoA", + "monoamine oxidase" + ] + }, + { + "id": "10567", + "type": "gene", + "text": "Tumor necrosis factor ( TNF ) is reported to cause a shock syndrome similar to that produced by endotoxin ( LPS ) .", + "entities": [ + "Tumor necrosis factor", + "TNF" + ] + }, + { + "id": "10568", + "type": "gene", + "text": "The initial translation protein encoded by the cDNA is 53 , 932 kDa and possesses a hydrophilic amino acid composition with glutamic acid comprising 22 % of the total amino acid residues .", + "entities": [] + }, + { + "id": "10569", + "type": "gene", + "text": "In addition , a catalytically inactive version of the Src family member , Lck ( lymphoid cell kinase ) , was expressed , purified , and evaluated as a Csk substrate .", + "entities": [ + "Src family", + "Lck", + "lymphoid cell kinase", + "Csk" + ] + }, + { + "id": "10570", + "type": "gene", + "text": "Increased dietary energy decreased PAB and the use of added dietary CO rather than PF decreased PSHL in broiler breeders between 26 and 47 wk of age .", + "entities": [] + }, + { + "id": "10571", + "type": "gene", + "text": "UK ' s biotechnology lacking specialists .", + "entities": [] + }, + { + "id": "10572", + "type": "gene", + "text": "The greatest difference between the Ad7 and Ad5 DBPs is the absence , in the Ad7 protein , of 12 amino acids located between the two functional domains in the Ad5 protein ( amino acids 151 - 162 ) .", + "entities": [ + "Ad7 and Ad5 DBPs" + ] + }, + { + "id": "10573", + "type": "gene", + "text": "Further outbreaks of ocular disease in farmed red deer calves caused by HVC - 1 were investigated .", + "entities": [] + }, + { + "id": "10574", + "type": "gene", + "text": "This intron occupies a conserved position corresponding to that of intron 1 in the transit peptide region of chloroplast GAPDH genes ( GapA and GapB ) of higher plants .", + "entities": [ + "chloroplast GAPDH genes", + "GapA", + "GapB" + ] + }, + { + "id": "10575", + "type": "gene", + "text": "The subjects were shown to be capable of assessing integrally the value of accelerations and estimating it with an error of 0 . 1 - 0 . 12 g .", + "entities": [] + }, + { + "id": "10576", + "type": "gene", + "text": "The RAP74 subunit of TFIIF alone contained the stimulatory activity and the minimal region sufficient for stimulation corresponds to COOH - terminal residues 358 - 517 .", + "entities": [ + "RAP74 subunit", + "TFIIF" + ] + }, + { + "id": "10577", + "type": "gene", + "text": "We have determined the structure of the WNT - 2B gene .", + "entities": [ + "WNT - 2B gene" + ] + }, + { + "id": "10578", + "type": "gene", + "text": "A comparison of the predicted polypeptide sequence of the Drosophila protein with the equivalent subunits from mouse and yeast suggests that they are closely related and defines three conserved regions which are likely to be important for enzyme activity .", + "entities": [] + }, + { + "id": "10579", + "type": "gene", + "text": "The influence of adrenergic nerves of the response of blood vessels in the rabbit ear to 2 - - phenylalanine - 8 - lysine vasopressin ( Octapressin ) .", + "entities": [ + "2 - - phenylalanine - 8 - lysine vasopressin", + "Octapressin" + ] + }, + { + "id": "10580", + "type": "gene", + "text": "Peter Elfer explores the implications of the ruling .", + "entities": [] + }, + { + "id": "10581", + "type": "gene", + "text": "Pseudomonas aeruginosa strains infecting patients with cystic fibrosis ( CF ) acquire a mucoid phenotype due to overproduction of alginate .", + "entities": [] + }, + { + "id": "10582", + "type": "gene", + "text": "This resulted in a complete inhibition of Site - 1 cleavage that was restored by concomitant overexpression of full - length SCAP .", + "entities": [ + "SCAP" + ] + }, + { + "id": "10583", + "type": "gene", + "text": "Genomic Southern blot analysis of rat EFIA ( gene encoding enhancer factor I subunit A ) reveals a complex band pattern when cDNA subfragment probes are used .", + "entities": [ + "rat EFIA", + "enhancer factor I subunit A" + ] + }, + { + "id": "10584", + "type": "gene", + "text": "Myasthenia gravis is an autoimmune disease resulting from the production of antibodies against the ACh receptors of the neuromuscular synapse .", + "entities": [ + "ACh receptors" + ] + }, + { + "id": "10585", + "type": "gene", + "text": "Substitution of the Ser - Thr sites with the phosphomimetic Asp generated a constitutively active form of IRF - 3 that functioned as a very strong activator of promoters containing PRDI - PRDIII or ISRE regulatory elements .", + "entities": [ + "IRF - 3", + "PRDI", + "PRDIII", + "ISRE regulatory elements" + ] + }, + { + "id": "10586", + "type": "gene", + "text": "Five concensus poly A addition sites are located in the 350 base pairs immediately following the protein IX coding region .", + "entities": [ + "protein IX" + ] + }, + { + "id": "10587", + "type": "gene", + "text": "We report here that in cultured Jurkat T cells , Cbl is coprecipitated with antibody against the adapter protein Grb2 .", + "entities": [ + "Cbl", + "adapter protein Grb2" + ] + }, + { + "id": "10588", + "type": "gene", + "text": "S6 kinase activation requires displacement of this inhibitory segment , which is proposed to occur consequent to its multiple phosphorylation .", + "entities": [ + "S6 kinase" + ] + }, + { + "id": "10589", + "type": "gene", + "text": "Studied groups were ( 1 ) untreated control , n = 12 ; ( 2 ) FK - 1 , n = 8 ; ( 3 ) FK - 3 , n = 8 .", + "entities": [] + }, + { + "id": "10590", + "type": "gene", + "text": "IFN alpha and IFN gamma inducibility is mediated by a single element : a high affinity , nearly palindromic version of the IFN gamma activation site ( GAS ) .", + "entities": [ + "IFN alpha", + "IFN gamma", + "IFN gamma activation site", + "GAS" + ] + }, + { + "id": "10591", + "type": "gene", + "text": "ISIS 5 possibilities .", + "entities": [] + }, + { + "id": "10592", + "type": "gene", + "text": "We found the following : Specific mutations affected the precise carbohydrate structure and folding of the HA trimer .", + "entities": [ + "HA trimer" + ] + }, + { + "id": "10593", + "type": "gene", + "text": "Many mammary tumors induced by mouse mammary tumor virus ( MMTV ) contain a provirus in the same region of the host - cell genome , leading to expression of a putative cellular oncogene called int - 1 .", + "entities": [ + "int - 1" + ] + }, + { + "id": "10594", + "type": "gene", + "text": "Epithelial and corneal thickness measurements by in vivo confocal microscopy through focusing ( CMTF ) .", + "entities": [] + }, + { + "id": "10595", + "type": "gene", + "text": "Both proteins were shown to be constitutively associated with tubulin .", + "entities": [ + "tubulin" + ] + }, + { + "id": "10596", + "type": "gene", + "text": "Data supported the brevity of the WISC - III short form and the criterion - related validity of both the K - FAST and and Kaufman Short Neuropsychological Assessment Procedure ( K - SNAP ) .", + "entities": [] + }, + { + "id": "10597", + "type": "gene", + "text": "Factors associated with afterdrop included age , end - of - surgery temperature ( both positively ) and body mass ( negatively ) .", + "entities": [] + }, + { + "id": "10598", + "type": "gene", + "text": "In general , two separate high - performance liquid chromatographic runs were performed , one for the gamma - aminobutyric acid determination and one for the determination of the monoamines .", + "entities": [] + }, + { + "id": "10599", + "type": "gene", + "text": "Mycoplasma pneumoniae was isolated from the pleural fluid of this patient .", + "entities": [] + }, + { + "id": "10600", + "type": "gene", + "text": "The DNA binding and multimerization activities of c - Myb appear to be unaffected by the S528A substitution , suggesting that phosphorylation of serine 528 may mediate its effect on the transcription transactivating activity of c - Myb by regulating interactions with other proteins .", + "entities": [ + "c - Myb", + "c - Myb" + ] + }, + { + "id": "10601", + "type": "gene", + "text": "At both water temperatures , VO2 increased linearly with increasing swimming velocity .", + "entities": [] + }, + { + "id": "10602", + "type": "gene", + "text": "In patients who had received no previous drug treatment , log baseline plasma renin activity and change in mean blood pressure after SQ 20881 correlated significantly ( r = 0 . 651 , P less than 0 . 05 ) .", + "entities": [ + "plasma renin" + ] + }, + { + "id": "10603", + "type": "gene", + "text": "2 .", + "entities": [] + }, + { + "id": "10604", + "type": "gene", + "text": "A novel , testis - specific mRNA transcript encoding an NH2 - terminal truncated nitric - oxide synthase .", + "entities": [ + "testis - specific mRNA transcript", + "NH2 - terminal truncated nitric - oxide synthase" + ] + }, + { + "id": "10605", + "type": "gene", + "text": "mRNA diversity represents a major theme of neuronal nitric - oxide synthase ( nNOS ) gene expression in somatic cells / tissues .", + "entities": [ + "neuronal nitric - oxide synthase", + "nNOS" + ] + }, + { + "id": "10606", + "type": "gene", + "text": "Transcripts of the immunoglobulin C mu gene vary in structure and splicing during lymphoid development .", + "entities": [ + "immunoglobulin C mu gene" + ] + }, + { + "id": "10607", + "type": "gene", + "text": "The severity of pathologic changes increased with the magnitude of percussion .", + "entities": [] + }, + { + "id": "10608", + "type": "gene", + "text": "Using 5 ng / mL as the cutoff , the sensitivity of CEA was 68 % .", + "entities": [ + "CEA" + ] + }, + { + "id": "10609", + "type": "gene", + "text": "The gene amplification model of Coquelle et al .", + "entities": [] + }, + { + "id": "10610", + "type": "gene", + "text": "Outcome of severe congenital hypothyroidism .", + "entities": [] + }, + { + "id": "10611", + "type": "gene", + "text": "Pneumoscrotum is a rare condition that receives little discussion in standard texts of urology .", + "entities": [] + }, + { + "id": "10612", + "type": "gene", + "text": "To investigate the functions of GE , IG , and GS sequences in transcription , we constructed plasmids containing cDNAs of the full - length SV5 genome in which the gene junction sequences ( GE , IG , and GS sequences ) located between the hemagglutinin - neuraminidase ( HN ) and the polymerase ( L ) genes were replaced with the counterpart sequences from other gene junctions .", + "entities": [ + "hemagglutinin - neuraminidase", + "HN", + "polymerase ( L ) genes" + ] + }, + { + "id": "10613", + "type": "gene", + "text": "When cells were microinjected with TFOs designed to bind to a 30 - bp polypurine site situated between the two TK genes , recombination was observed at frequencies in the range of 1 % , 2 , 500 - fold above the background .", + "entities": [ + "TK genes" + ] + }, + { + "id": "10614", + "type": "gene", + "text": "Here we examine the potential for VP16 protein - protein interactions specific to virus - infected cells and show that VP16 copurifies in a highly enriched fraction with a single major polypeptide which we identify as the virus - encoded structural protein VP22 .", + "entities": [ + "VP16", + "VP16", + "VP22" + ] + }, + { + "id": "10615", + "type": "gene", + "text": "Studies using the yeast two - hybrid system also did not provide evidence for the formation of a VDR - TR protein - protein interaction .", + "entities": [ + "VDR", + "TR" + ] + }, + { + "id": "10616", + "type": "gene", + "text": "Cheung and S .", + "entities": [] + }, + { + "id": "10617", + "type": "gene", + "text": "One class of plasmids contained tRNA ( His ) genes and conferred efficient suppression only when cells were starved for histidine ; these plasmids suppressed a gcn2 deletion much less efficiently than they suppressed gcn2 - 507 .", + "entities": [ + "tRNA ( His ) genes", + "gcn2", + "gcn2 - 507" + ] + }, + { + "id": "10618", + "type": "gene", + "text": "RESULTS : Circulating leptin concentrations in AN were 3 . 5 + / - 0 . 5 versus 7 . 6 + / - 1 . 2 ng / ml in control subjects .", + "entities": [ + "leptin" + ] + }, + { + "id": "10619", + "type": "gene", + "text": "The 3 ' fragment was shown to accumulate as full - length mRNA disappeared in actinomycin D - treated cells , indicating a precursor - product relationship .", + "entities": [] + }, + { + "id": "10620", + "type": "gene", + "text": "Initially , we observed that unmutated p53 is strongly expressed in premalignant mammary glands and in mammary tumors derived from the MMTV - c - myc strain .", + "entities": [ + "p53", + "c - myc" + ] + }, + { + "id": "10621", + "type": "gene", + "text": "SRY - related cDNA encoding a protein with a high - mobility - group ( HMG ) box and a leucine zipper motif , which was designated SOX - LZ , was isolated from a rainbow trout testis cDNA library .", + "entities": [ + "SRY - related cDNA", + "high - mobility - group", + "HMG", + "SOX - LZ" + ] + }, + { + "id": "10622", + "type": "gene", + "text": "Biol .", + "entities": [] + }, + { + "id": "10623", + "type": "gene", + "text": "In the chicken liver , levels of chicken MT mRNA were rapidly induced by metals ( Cd2 + , Zn2 + , Cu2 + ) , glucocorticoids and lipopolysaccharide .", + "entities": [ + "chicken MT mRNA" + ] + }, + { + "id": "10624", + "type": "gene", + "text": "I .", + "entities": [] + }, + { + "id": "10625", + "type": "gene", + "text": "Increasing the cut - off point to 3 positive responses decreased the sensitivity to 81 % and increased the specificity to 94 % .", + "entities": [] + }, + { + "id": "10626", + "type": "gene", + "text": "Deletion and mutational analyses revealed two positive cis - regulatory elements in this region that are essential for CSX1 expression in cardiomyocytes .", + "entities": [ + "CSX1" + ] + }, + { + "id": "10627", + "type": "gene", + "text": "The small IGF - binding protein is abundant in human amniotic fluid .", + "entities": [ + "small IGF - binding protein" + ] + }, + { + "id": "10628", + "type": "gene", + "text": "Thus , growth factor activation of ER can mediate transactivation vs ER / Sp1 binding to GC - rich sites and represents a novel pathway for ligand - independent ER action .", + "entities": [ + "ER", + "ER", + "Sp1", + "ER" + ] + }, + { + "id": "10629", + "type": "gene", + "text": "Furthermore , the negative transcriptional effect of COUP - TFs is dominant over the activating effect of the Oct4 embryonic stem cell - specific enhancer .", + "entities": [ + "COUP - TFs", + "Oct4 embryonic stem cell - specific enhancer" + ] + }, + { + "id": "10630", + "type": "gene", + "text": "Validation of the survey of work styles : a profile measure of the type A behaviour pattern .", + "entities": [] + }, + { + "id": "10631", + "type": "gene", + "text": "CKbeta4GT - II is predicted to encode a type II transmembrane glycoprotein of 43 kDa with five potential N - linked glycosylation sites .", + "entities": [ + "CKbeta4GT - II", + "type II transmembrane glycoprotein" + ] + }, + { + "id": "10632", + "type": "gene", + "text": "The pathogenesis of Dupuytren ' s contracture", + "entities": [] + }, + { + "id": "10633", + "type": "gene", + "text": "Comparison of human and murine blk sequences indicated that they share 86 % amino acid identity , the most conserved region being the catalytic domain ( 93 % identity ) .", + "entities": [ + "human and murine blk sequences" + ] + }, + { + "id": "10634", + "type": "gene", + "text": "On the other hand , forced overexpression of the wild type , but not the kinase - inactivated mutant of nm23H1 , converted the GDP - bound forms of Rac1 , Cdc42 , and RhoA to their GTP - bound forms in vitro by its nucleoside diphosphate kinase activity , but nm23H1 alone apparently did not produce the GTP - bound form of these GTPases in vivo .", + "entities": [ + "nm23H1", + "Rac1", + "Cdc42", + "RhoA", + "nucleoside diphosphate kinase", + "nm23H1", + "GTPases" + ] + }, + { + "id": "10635", + "type": "gene", + "text": "It is impossible to define only one clinical outline because both symptomatic and asymptomatic infected NB may be found with gestational age at term and pre - term and when born with a weight above or below 2000 g .", + "entities": [] + }, + { + "id": "10636", + "type": "gene", + "text": "CONCLUSIONS : These routinely collected data provided quantitative estimates of changes in CBZ Cl / F due to comedication and an age - related decrease in Cl / F The derived regression equations reasonably predicted concentrations in a separate validation set .", + "entities": [] + }, + { + "id": "10637", + "type": "gene", + "text": "METHODS AND RESULTS : In 25 open - chest , anesthetized dogs , progressive circumflex artery stenosis led to a concordant decrease of circumflex artery resting and hyperemic flow , coronary flow reserve , and inverse angiographic mean transit time Tmicro - 1 ( P < . 01 ) .", + "entities": [] + }, + { + "id": "10638", + "type": "gene", + "text": "They share many downstream targets , including remodeling of the actin cytoskeleton , activation of p70 ( S6 ) kinase and c - jun N - terminal kinase ( JNK ) , and regulation of transcription and cell proliferation .", + "entities": [ + "actin", + "p70 ( S6 ) kinase", + "c - jun N - terminal kinase", + "JNK" + ] + }, + { + "id": "10639", + "type": "gene", + "text": "The study suggests the presence of an anatomical sphincter at the RSJ which seems to regulate the passage of stools from the sigmoid colon to the rectum .", + "entities": [] + }, + { + "id": "10640", + "type": "gene", + "text": "Gtx mRNA accumulates in parallel with the RNAs encoding the major structural proteins of myelin , myelin basic protein ( MBP ) , and proteolipid protein ( PLP ) during postnatal brain development ; Gtx mRNA decreases in parallel with MBP and PLP mRNAs in the brains of myelin - deficient rats , which have a point mutation in the PLP gene .", + "entities": [ + "Gtx mRNA", + "myelin basic protein", + "MBP", + "proteolipid protein", + "PLP", + "Gtx mRNA", + "MBP", + "PLP mRNAs", + "PLP gene" + ] + }, + { + "id": "10641", + "type": "gene", + "text": "Interleukin - 12 ( IL - 12 ) is a cytokine produced by peripheral blood mononuclear cells ( PBMC ) that causes interferon - gamma ( IFN - gamma ) production and enhancement of cell - mediated cytotoxicity .", + "entities": [ + "Interleukin - 12", + "IL - 12", + "interferon - gamma", + "IFN - gamma" + ] + }, + { + "id": "10642", + "type": "gene", + "text": "MK - 801 administration resulted in a biphasic response in seizure latency .", + "entities": [] + }, + { + "id": "10643", + "type": "gene", + "text": "Histological examination showed lichenoid changes , acantholytic blister formation and apoptotic keratinocytes .", + "entities": [] + }, + { + "id": "10644", + "type": "gene", + "text": "Protein kinases play pivotal roles in the control of many cellular processes .", + "entities": [] + }, + { + "id": "10645", + "type": "gene", + "text": "Because Trp53 ( the mouse homolog of human TP53 ) is located with Tk1 on chromosome 11 and is critical in regulating cellular responses following exposure to DNA damaging agents , we wanted to determine if these mouse lymphoma cells harbor mutations in Trp53 .", + "entities": [ + "Trp53", + "mouse homolog of human TP53", + "Tk1", + "Trp53" + ] + }, + { + "id": "10646", + "type": "gene", + "text": "All 9 untreated patients underwent laparoscopy , which identified 3 intra - abdominal , 3 vanished and 2 peeping testes , and 1 atrophic testis in the inguinal canal .", + "entities": [] + }, + { + "id": "10647", + "type": "gene", + "text": "The well - known Rel / NF - kappaB family of vertebrate transcription factors comprises a number of structurally related , interacting proteins that bind DNA as dimers and whose activity is regulated by subcellular location .", + "entities": [ + "Rel", + "NF - kappaB" + ] + }, + { + "id": "10648", + "type": "gene", + "text": "PURPOSE : A two - generation consanguineous Pakistani family with autosomal recessive Leber congenital amaurosis ( LCA , MIM 204 , 000 ) and keratoconus was identified .", + "entities": [] + }, + { + "id": "10649", + "type": "gene", + "text": "Oscillatory exchange of atoms between traps containing Bose condensates .", + "entities": [] + }, + { + "id": "10650", + "type": "gene", + "text": "In that case , the ratio of brush abrasion was 0 . 268 , compressive and transverse strength , 124 . 3 and 86 . 3 MPa respectively , hardness , 43 . 2 Hk , water absorption 14 . 2 micrograms / mm3 and thermal expansion coefficient , 47 . 4 x 10 ( - 6 ) / degrees C .", + "entities": [] + }, + { + "id": "10651", + "type": "gene", + "text": "Flap survival depends on the development of a small number of vascular connections between vessels arising from the pedicle and preexisting dermal vessels .", + "entities": [] + }, + { + "id": "10652", + "type": "gene", + "text": "Amino acid residues of beta 1 ' , alpha A ' , alpha B ' , and the loop containing His539 of the RNase H domain interact with the primer strand of the dsDNA .", + "entities": [ + "RNase H domain" + ] + }, + { + "id": "10653", + "type": "gene", + "text": "None of the measured parameters ( heart contents of neutral lipids , total phospholipids , phosphatidylcholine , phosphatidylethanolamine , diphosphatidylglycerol , sphingomyelin and fatty acid composition of each phospholipid class ) appeared to be related with the grading of the lesions .", + "entities": [] + }, + { + "id": "10654", + "type": "gene", + "text": "JNK and p38 are constitutively present in the nucleus , and DNA - bound c - JUN and ATF - 2 are stably contacted by JNK and p38 , respectively .", + "entities": [ + "JNK", + "p38", + "c - JUN", + "ATF - 2", + "JNK", + "p38" + ] + }, + { + "id": "10655", + "type": "gene", + "text": "These utilisation data imply annual drug costs in the range of $ US 480 , 000 to $ US 3 , 600 , 000 for TNF antagonists for RA per 1 million population .", + "entities": [ + "TNF" + ] + }, + { + "id": "10656", + "type": "gene", + "text": "The B cell antigen receptor activates the Akt ( protein kinase B ) / glycogen synthase kinase - 3 signaling pathway via phosphatidylinositol 3 - kinase .", + "entities": [ + "B cell antigen receptor", + "Akt", + "protein kinase B", + "glycogen synthase kinase - 3", + "phosphatidylinositol 3 - kinase" + ] + }, + { + "id": "10657", + "type": "gene", + "text": "Quantitative PCR studies indicated that synthesis and transport of vector DNA into the nucleus were similar for macrophages infected with the clone 239 and 316 pseudotypes , suggesting that the restriction for SIVmac239 infection is after reverse transcription and nuclear import of viral DNA .", + "entities": [] + }, + { + "id": "10658", + "type": "gene", + "text": "We have now shown that in vivo phosphorylation of 14 - 3 - 3 zeta at the CKIalpha site ( Thr - 233 ) negatively regulates its binding to c - Raf , and may be important in Raf - mediated signal transduction .", + "entities": [ + "14 - 3 - 3 zeta", + "CKIalpha site ( Thr - 233 )", + "c - Raf", + "Raf" + ] + }, + { + "id": "10659", + "type": "gene", + "text": "We previously reported that Tax induced cell cycle progression from G0 / G1 phase to S and G2 / M phases in human T - cell line Kit 225 cells .", + "entities": [ + "Tax" + ] + }, + { + "id": "10660", + "type": "gene", + "text": "This specific methylation pattern caused inactivation of the HSV tk gene , while methylation of the cytosine residues within the nucleotide sequence from + 811 to + 1309 had no effect on HSV tk gene activity .", + "entities": [ + "HSV tk gene", + "HSV tk gene" + ] + }, + { + "id": "10661", + "type": "gene", + "text": "Acad .", + "entities": [] + }, + { + "id": "10662", + "type": "gene", + "text": "The inhibition by cytosolic Ca2 + was caused by a decrease in cooperativity and by a shift in EC50 toward higher InsP3 concentrations .", + "entities": [] + }, + { + "id": "10663", + "type": "gene", + "text": "The favourable effect of thymic shielding was also reflected in a significant increase of LD50 / 30 , and the dose reduction factor was equal to 2 .", + "entities": [] + }, + { + "id": "10664", + "type": "gene", + "text": "To modulate transcription , regulatory factors communicate with basal transcription factors and / or RNA polymerases in a variety of ways .", + "entities": [ + "RNA polymerases" + ] + }, + { + "id": "10665", + "type": "gene", + "text": "Drug interactions have been found with drugs that compete for the same CYP450 isoenzymes as statins .", + "entities": [ + "CYP450 isoenzymes" + ] + }, + { + "id": "10666", + "type": "gene", + "text": "An approach to a biomathematical model of lymphocytopoiesis .", + "entities": [] + }, + { + "id": "10667", + "type": "gene", + "text": "Nonetheless , that ventricular afferents , in certain special settings , are able to induce e . g . generalised vasodilation and hypotension cannot be excluded .", + "entities": [] + }, + { + "id": "10668", + "type": "gene", + "text": "Topical 1 percent isoproterenol in the presence of the phosphodiesterase inhibitor theophylline was tested for its ability to stimulate the rate of aqueous humor flow through the anterior chamber of the normal and the partially adrenergically denervated human eye ( Horner ' s syndrome ) .", + "entities": [] + }, + { + "id": "10669", + "type": "gene", + "text": "The alpha T3 - 1 cell line , a GnRH - responsive gonadotroph cell line developed by targeted oncogenesis in transgenic mice , was used to study regulation of the glycoprotein hormone alpha - subunit by activin .", + "entities": [ + "GnRH", + "glycoprotein hormone alpha - subunit", + "activin" + ] + }, + { + "id": "10670", + "type": "gene", + "text": "The elevation of cyclic AMP ( cAMP ) levels in the cell downregulates the activity of the Raf - 1 kinase .", + "entities": [ + "Raf - 1 kinase" + ] + }, + { + "id": "10671", + "type": "gene", + "text": "Infrared measurements of temperature changes and estimates of the heating produced at the mical .", + "entities": [] + }, + { + "id": "10672", + "type": "gene", + "text": "Genetics Institute has developed and launched oprelvekin ( rhIL - 11 ; Neumega ) , a recombinant form of human IL - 11 .", + "entities": [ + "oprelvekin", + "rhIL - 11", + "human IL - 11" + ] + }, + { + "id": "10673", + "type": "gene", + "text": "Protein films are distinctly different in mechanical profiles from those films made of other materials .", + "entities": [] + }, + { + "id": "10674", + "type": "gene", + "text": "The results suggest that the greater estrogenic influence associated with the ethinyl estradiol - containing OC resulted in inhibition of coronary artery atherosclerosis despite a pronounced progestin - induced lowering of plasma HDL cholesterol concentration and , further , that hormonal balance may have a marked influence on the relationship between plasma lipids and atherogenesis .", + "entities": [ + "HDL cholesterol" + ] + }, + { + "id": "10675", + "type": "gene", + "text": "Viral and atypical pathogens as causes of type 1 acute exacerbations of chronic bronchitis .", + "entities": [] + }, + { + "id": "10676", + "type": "gene", + "text": "In metastasis - free patients , the best results were obtained with tumor diameters under 2 cm regardless of their localization in lung tissue and with 2 - - 4 . 9 cm tumors embedded in lung parenchyma .", + "entities": [] + }, + { + "id": "10677", + "type": "gene", + "text": "After a baseline study , WPW syndrome was simulated by stimulation at seven different sites around the base of the ventricles , and RNV ' s were obtained .", + "entities": [] + }, + { + "id": "10678", + "type": "gene", + "text": "A comparative study of the cortical end of the auditory analyzer during postnatal ontogenesis in lower monkeys and man", + "entities": [] + }, + { + "id": "10679", + "type": "gene", + "text": "We performed the present study to clarify the relationship between the DOX binding ability ( % DB ) and the histologic response , rate of decrease in tumor volume of malignant soft tissue tumors after preoperative chemotherapy and prognosis .", + "entities": [] + }, + { + "id": "10680", + "type": "gene", + "text": "It is the oxidation peak of this product , arising in acidic media at 0 . 42 V , which was analysed using DPV , again following the accumulation of clenbuterol at the Nafion - modified CPE .", + "entities": [] + }, + { + "id": "10681", + "type": "gene", + "text": "This DNA containing promoter activity has been sequenced in its entirety and found to contain multiple putative regulatory sites .", + "entities": [] + }, + { + "id": "10682", + "type": "gene", + "text": "In concert with the coactivator CREB binding protein / p300 , which interacts with GABPalpha , the binding of GABPalpha and - beta to the dyad symmetry element controls the induction of IL - 16 promoter in T cells .", + "entities": [ + "CREB binding protein", + "p300", + "GABPalpha", + "GABPalpha and - beta", + "IL - 16 promoter" + ] + }, + { + "id": "10683", + "type": "gene", + "text": "In the 3 ' flanking region of the 27 kDa zein gene , several AATAAA - like sequences and a sequence resembling the mammalian GT - rich sequence are present around the polyadenylation sites .", + "entities": [ + "27 kDa zein gene" + ] + }, + { + "id": "10684", + "type": "gene", + "text": "New beta - blocking drugs have been introduced which may prove beneficial in certain clinical situations since they exert more selective blockade of the cardiac receptors ( beta1 ) as opposed to smooth muscle receptors ( beta2 ) .", + "entities": [ + "cardiac receptors", + "beta1", + "smooth muscle receptors", + "beta2" + ] + }, + { + "id": "10685", + "type": "gene", + "text": "However , expression of sigma 3 from S4 ( 3 ' UTR / S1 ) , which included the PKR activator sequence from S1 within the 3 ' - UTR of S4 , was comparable to that from wild - type S4 .", + "entities": [ + "sigma 3", + "S4", + "3 ' UTR / S1", + "PKR activator sequence", + "S1", + "3 ' - UTR of S4", + "wild - type S4" + ] + }, + { + "id": "10686", + "type": "gene", + "text": "Taken together , our data suggest that Dbf8p plays an essential role in chromosome segregation .", + "entities": [ + "Dbf8p" + ] + }, + { + "id": "10687", + "type": "gene", + "text": "Recombination , replication , repair : from complexity to harmony .", + "entities": [] + }, + { + "id": "10688", + "type": "gene", + "text": "Transcription initiation occurred predominantly at the putative sigmaA - dependent promoter in exponentially growing cells and was induced under stress conditions .", + "entities": [ + "sigmaA - dependent promoter" + ] + }, + { + "id": "10689", + "type": "gene", + "text": "The enzymic hydrolysis of urea produces ammonia which causes a vivid yellow to purple colour change in the pH indicator .", + "entities": [] + }, + { + "id": "10690", + "type": "gene", + "text": "The virus - associated VAI RNA of adenovirus is a small highly structured RNA that is required for the efficient translation of cellular and viral mRNAs at late times after infection .", + "entities": [ + "VAI" + ] + }, + { + "id": "10691", + "type": "gene", + "text": "Lengthy and repeated hemodialyses were required to lower lithemia to nontoxic ranges .", + "entities": [] + }, + { + "id": "10692", + "type": "gene", + "text": "This analysis , together with a consideration of the SCBs found upstream of known SWI4 , 6 - dependent genes , leads to the proposal of a revised consensus sequence for this important regulatory element .", + "entities": [ + "SWI4 , 6" + ] + }, + { + "id": "10693", + "type": "gene", + "text": "However , deletions of the C terminal 11 or 14 amino acids had more substantial effects .", + "entities": [] + }, + { + "id": "10694", + "type": "gene", + "text": "Neither CES1 nor CES4 is essential for cell growth , and a double deletion mutant is viable .", + "entities": [ + "CES1", + "CES4" + ] + }, + { + "id": "10695", + "type": "gene", + "text": "The growth factor receptor - bound protein 2 ( Grb2 ) adaptor when complexed with Sos ( Son of sevenless ) , the exchange factor of Ras , conveys the signal induced by tyrosine kinase - activated receptor to Ras by recruiting Sos to the membrane , allowing activation of Ras .", + "entities": [ + "growth factor receptor - bound protein 2", + "Grb2", + "Sos", + "Son of sevenless", + "Ras", + "tyrosine kinase - activated receptor", + "Ras", + "Sos", + "Ras" + ] + }, + { + "id": "10696", + "type": "gene", + "text": "Signaling from the small GTP - binding proteins Rac1 and Cdc42 to the c - Jun N - terminal kinase / stress - activated protein kinase pathway .", + "entities": [ + "small GTP - binding proteins Rac1", + "Cdc42", + "c - Jun N - terminal kinase", + "stress - activated protein kinase" + ] + }, + { + "id": "10697", + "type": "gene", + "text": "The isolation of this gene was based on the identification of the Y - 231 cosmid that contains CpG rich sequences ( HTF islands ) in its human insert .", + "entities": [] + }, + { + "id": "10698", + "type": "gene", + "text": "In addition , we demonstrate that the production of active recombinant telomerase requires a factor in rabbit reticulocyte lysate that promotes ribonucleoprotein assembly .", + "entities": [ + "active recombinant telomerase" + ] + }, + { + "id": "10699", + "type": "gene", + "text": "Compared to controls , both UB and OCS rats showed a small but significant post - operative reduction in the nocturnality of drinking .", + "entities": [] + }, + { + "id": "10700", + "type": "gene", + "text": "The use of antibodies to the polypyrimidine tract binding protein ( PTB ) to analyze the protein components that assemble on alternatively spliced pre - mRNAs that use distant branch points .", + "entities": [ + "polypyrimidine tract binding protein", + "PTB" + ] + }, + { + "id": "10701", + "type": "gene", + "text": "EB - 1 , a tyrosine kinase signal transduction gene , is transcriptionally activated in the t ( 1 ; 19 ) subset of pre - B ALL , which express oncoprotein E2a - Pbx1 .", + "entities": [ + "EB - 1", + "tyrosine kinase signal transduction gene", + "E2a", + "Pbx1" + ] + }, + { + "id": "10702", + "type": "gene", + "text": "Despite supraphysiologic E2 concentrations , however , cervical mucus scores were significantly reduced in the CC - treated group ( P less than 0 . 01 ) .", + "entities": [] + }, + { + "id": "10703", + "type": "gene", + "text": "Methods included 24 - hour dietary recall , menu weights , and recipe analysis .", + "entities": [] + }, + { + "id": "10704", + "type": "gene", + "text": "Substrate specificity of the RNase activity of yeast RNA polymerase III .", + "entities": [ + "RNase", + "yeast RNA polymerase III" + ] + }, + { + "id": "10705", + "type": "gene", + "text": "Three radiologists without knowledge of patients ' data and treatment analyzed 30 angiograms with and 30 examinations without PGF .", + "entities": [] + }, + { + "id": "10706", + "type": "gene", + "text": "TCR alpha ( TCRA ) expression was examined in RNA samples from PBMC and isolated populations of CD4 + , CD8 + , and DN T cells from 15 healthy individuals .", + "entities": [ + "TCR alpha", + "TCRA", + "CD4 +", + "CD8 +" + ] + }, + { + "id": "10707", + "type": "gene", + "text": "Levels of serum IgE were measured monthly , and nasal IgE was measured at the height and end of the season .", + "entities": [ + "IgE", + "IgE" + ] + }, + { + "id": "10708", + "type": "gene", + "text": "The results showed that fog , up to a level of base plus fog of 0 . 6 optical density units , had no influence on the diagnostic accuracy in the absence of any compensation .", + "entities": [] + }, + { + "id": "10709", + "type": "gene", + "text": "Hippocampal stimulation overlapping conditioned stimulus preexposure produced attenuation of latent inhibition , as did stimulation presented during conditioning after preexposure .", + "entities": [] + }, + { + "id": "10710", + "type": "gene", + "text": "In the controls , it was found that all right - handed and 10 out of 14 left - handed control subjects showed a right VHF ( i . e . , left hemisphere ) advantage .", + "entities": [] + }, + { + "id": "10711", + "type": "gene", + "text": "The purposes of this study were 1 ) to examine the effect of high intensity , low frequency transcutaneous electrical nerve stimulation at auricular acupuncture points on experimental pain threshold measured at the wrist and 2 ) to determine the changes in effect over time .", + "entities": [] + }, + { + "id": "10712", + "type": "gene", + "text": "In contrast , the distribution of endocytic markers is not affected .", + "entities": [] + }, + { + "id": "10713", + "type": "gene", + "text": "T4 and FT4I followed parallel courses in both groups ; during the first 45 days , however , the values were significantly lower in premature infants under 34 weeks ' EGA than in term infants ( P less than 0 . 001 ) .", + "entities": [] + }, + { + "id": "10714", + "type": "gene", + "text": "Plasma thromboxane B2 levels in the older group were about double those in younger piglets .", + "entities": [] + }, + { + "id": "10715", + "type": "gene", + "text": "NaeI , a novel DNA endonuclease , shows topoisomerase and recombinase activities when a Lys residue is substituted for Leu 43 .", + "entities": [ + "NaeI", + "DNA endonuclease", + "topoisomerase", + "recombinase" + ] + }, + { + "id": "10716", + "type": "gene", + "text": "LHbeta is expressed in pituitary gonadotrope cells and CGbeta is expressed in placental trophoblast cells .", + "entities": [ + "LHbeta", + "CGbeta" + ] + }, + { + "id": "10717", + "type": "gene", + "text": "Neonatal Chagas disease : laboratory diagnosis during the first year of life", + "entities": [] + }, + { + "id": "10718", + "type": "gene", + "text": "Chemotherapy of metastasizing breast cancer", + "entities": [] + }, + { + "id": "10719", + "type": "gene", + "text": "This article comparatively evaluates five Generic Systems that describe the basic alternatives to composting facility design and control .", + "entities": [] + }, + { + "id": "10720", + "type": "gene", + "text": "Several studies have characterized the upstream regulatory region of c - fos , and identified cis - acting elements termed the cyclic AMP ( cAMP ) response elements ( CREs ) that are critical for c - fos transcription in response to a variety of extracellular stimuli .", + "entities": [ + "c - fos", + "c - fos" + ] + }, + { + "id": "10721", + "type": "gene", + "text": "The effects initiated from the nucleus accumbens septi were most marked .", + "entities": [] + }, + { + "id": "10722", + "type": "gene", + "text": "Between 1967 and 1994 , 495 patients underwent surgery for primary PTC at the Department of Surgery , Helsinki University Central Hospital .", + "entities": [] + }, + { + "id": "10723", + "type": "gene", + "text": "Following retransfusion , the affected epithelial lining appeared greatly distended over the oedematous lamina propria , with almost complete loss of structural detail .", + "entities": [] + }, + { + "id": "10724", + "type": "gene", + "text": "We compared the efficacy and costs of valacyclovir in preventing HSV reactivation among HSV seropositive autologous progenitor cell transplantation ( APCT ) patients with historical controls in whom intravenous acyclovir or no HSV prophylaxis were used .", + "entities": [] + }, + { + "id": "10725", + "type": "gene", + "text": "No serious side effects were observed .", + "entities": [] + }, + { + "id": "10726", + "type": "gene", + "text": "Overlapping cDNA clones were isolated and sequenced .", + "entities": [] + }, + { + "id": "10727", + "type": "gene", + "text": "Induction was reversed by coexpression of A - Fos , a dominant negative to AP - 1 .", + "entities": [ + "A - Fos", + "AP - 1" + ] + }, + { + "id": "10728", + "type": "gene", + "text": "Restoration of opponens function with transplantation of free composites dorsal pedal skin flap containing m . extensor hallucis brevis", + "entities": [] + }, + { + "id": "10729", + "type": "gene", + "text": "The Caenorhabditis elegans vitellogenin genes are subject to sex - , stage - , and tissue - specific regulation : they are expressed solely in the adult hermaphrodite intestine .", + "entities": [ + "Caenorhabditis elegans vitellogenin genes" + ] + }, + { + "id": "10730", + "type": "gene", + "text": "In such a manner , activated PKR inhibits cell growth and induces apoptosis , whereas disruption of normal PKR signaling results in unregulated cell growth .", + "entities": [ + "PKR", + "PKR" + ] + }, + { + "id": "10731", + "type": "gene", + "text": "SCFFWD1 may be critical for tumor development and suppression through regulation of beta - catenin protein stability .", + "entities": [ + "SCFFWD1", + "beta - catenin protein" + ] + }, + { + "id": "10732", + "type": "gene", + "text": "Signaling by tyrosine kinases involves direct associations between proteins with Src homology 2 ( SH2 ) domains and sites of tyrosine phosphorylation .", + "entities": [ + "tyrosine kinases", + "Src homology 2", + "SH2" + ] + }, + { + "id": "10733", + "type": "gene", + "text": "TBARS levels , oxygen - radical absorbing capacity assay and AFR release assessed by electron paramagnetic resonance ( EPR ) were used to explore the existence of oxidative stress in diabetes .", + "entities": [] + }, + { + "id": "10734", + "type": "gene", + "text": "Despite the favourable natural history of acute BI , mild , moderate , and severe posttraumatic changes were shown to appear as cicatricial - adhesive and atrophic processes , intracerebral cysts , porencephaly , which result in posttraumatic epilepsy , hydrocephalus , etc .", + "entities": [] + }, + { + "id": "10735", + "type": "gene", + "text": "Therefore , ICSBP may be involved in maintaining submaximal transcriptional activity of IFN - inducible genes in hematopoietic cells .", + "entities": [ + "ICSBP", + "IFN" + ] + }, + { + "id": "10736", + "type": "gene", + "text": "Initial estimates indicate that 27 , 193 people are either in receipt of or in need of mental handicap services .", + "entities": [] + }, + { + "id": "10737", + "type": "gene", + "text": "The gene ccpA encoding the catabolite control protein CcpA of Staphylococcus xylosus has been cloned and characterized .", + "entities": [ + "gene ccpA", + "catabolite control protein CcpA" + ] + }, + { + "id": "10738", + "type": "gene", + "text": "Transcription of the first operon coding for m - xylene - degrading enzymes on the TOL plasmid of Pseudomonas putida is activated by the xylR gene product in the presence of m - xylene .", + "entities": [ + "xylR gene product" + ] + }, + { + "id": "10739", + "type": "gene", + "text": "Strikingly , these cells contain a missense mutation of the p53 gene at codon 242 ( p53 ( 242 ) ) , which substitutes alanine for glycine .", + "entities": [ + "p53 gene", + "p53" + ] + }, + { + "id": "10740", + "type": "gene", + "text": "USA 80 , 3618 - 3622 ) The two proteins show 36 % identities in their amino acid sequence , in an alignment requiring six gaps .", + "entities": [] + }, + { + "id": "10741", + "type": "gene", + "text": "Airflow was measured with a custom - designed turbine and a 45 - ft . - long cable to reach the volume - measuring module .", + "entities": [] + }, + { + "id": "10742", + "type": "gene", + "text": "It is concluded that contact allergy to K - CG is common .", + "entities": [] + }, + { + "id": "10743", + "type": "gene", + "text": "The promoter activity of the proximal region was found to be restricted to a subset of prestalk cells .", + "entities": [] + }, + { + "id": "10744", + "type": "gene", + "text": "To overcome this problem , we have overexpressed Kex2p using the baculovirus / insect cell expression system .", + "entities": [ + "Kex2p" + ] + }, + { + "id": "10745", + "type": "gene", + "text": "In contrast to the myoD promoter , the myoD enhancer shows striking conservation between humans and mice both in its sequence and its distal position .", + "entities": [ + "myoD promoter", + "myoD enhancer" + ] + }, + { + "id": "10746", + "type": "gene", + "text": "The problem of disablement due to pulmonary tuberculosis , on the basis of an analysis of the history of 395 cases as observed in Gdansk in the years 1946 - 1965", + "entities": [] + }, + { + "id": "10747", + "type": "gene", + "text": "The viral oncoprotein E1A inhibits NFAT - dependent transactivation in a p300 - dependent manner .", + "entities": [ + "viral oncoprotein E1A", + "NFAT", + "p300" + ] + }, + { + "id": "10748", + "type": "gene", + "text": "Monitoring of rheumatoid arthritis .", + "entities": [] + }, + { + "id": "10749", + "type": "gene", + "text": "Thus , the system can be used to detect and study dynamic perfusion changes from the brain surface with minimal tissue damage .", + "entities": [] + }, + { + "id": "10750", + "type": "gene", + "text": "The pulpal tissues of the permanent mandibular molars were amputated and then dressed with calcium hydrate .", + "entities": [] + }, + { + "id": "10751", + "type": "gene", + "text": "We purified both proteins from human platelet membranes using DEAE - Sepharose chromatography followed by mAb F11 affinity chromatography .", + "entities": [ + "mAb F11" + ] + }, + { + "id": "10752", + "type": "gene", + "text": "The present treatment strategy in progressive disorders is mainly based on the complementary effect of intensive radiochemotherapy , autologous stem - cell transplantation and the rational use of cytokines , mostly colony - stimulating factors .", + "entities": [ + "colony - stimulating factors" + ] + }, + { + "id": "10753", + "type": "gene", + "text": "The proliferation - specific HNF - 3 / fork head homolog - 11B protein ( HFH - 11B ; also known as Trident and Win ) is a family member of the winged helix / fork head transcription factors and in regenerating liver its expression is reactivated prior to hepatocyte entry into DNA replication ( S phase ) .", + "entities": [ + "HNF - 3", + "fork head homolog - 11B", + "HFH - 11B", + "Trident", + "Win", + "winged helix", + "fork head" + ] + }, + { + "id": "10754", + "type": "gene", + "text": "In a gel retardation assay using HepG2 nuclear extracts , the 5 ' flanking sequence from - 74 to - 46 showed a shifted band .", + "entities": [] + }, + { + "id": "10755", + "type": "gene", + "text": "Here we report the isolation and characterization of the forkhead homologue in rhabdomyosarcoma ( FKHR ) , a recently described member of the hepatocyte nuclear factor 3 / forkhead homeotic gene family , as a nuclear hormone receptor ( NR ) intermediary protein .", + "entities": [ + "forkhead homologue in rhabdomyosarcoma", + "FKHR", + "hepatocyte nuclear factor 3", + "homeotic gene family", + "nuclear hormone receptor", + "NR" + ] + }, + { + "id": "10756", + "type": "gene", + "text": "The relationship between the rare complications mentioned above and the pathophysiology of Bartter ' s syndrome is still obscure .", + "entities": [] + }, + { + "id": "10757", + "type": "gene", + "text": "The murine Mov - 34 gene : full - length cDNA and genomic organization .", + "entities": [ + "murine Mov - 34 gene" + ] + }, + { + "id": "10758", + "type": "gene", + "text": "Retinoblastoma : a study of natural history and prognosis of 268 cases .", + "entities": [] + }, + { + "id": "10759", + "type": "gene", + "text": "We used the Toshiba IIDR system , which is composed of an X - ray TV system and a digital image managing circuit .", + "entities": [] + }, + { + "id": "10760", + "type": "gene", + "text": "Sterols in pollen .", + "entities": [] + }, + { + "id": "10761", + "type": "gene", + "text": "Nrf2 regulates expression of genes encoding enzymes with antioxidant ( e . g . heme oxygenase - 1 ( HO - 1 ) ) or xenobiotic detoxification ( e . g .", + "entities": [ + "Nrf2", + "heme oxygenase - 1", + "HO - 1" + ] + }, + { + "id": "10762", + "type": "gene", + "text": "Many cytokine receptors employ Janus protein tyrosine kinases ( Jaks ) and signal transducers and activators of transcription ( Stats ) for nuclear signaling .", + "entities": [ + "Janus protein tyrosine kinases", + "Jaks", + "signal transducers and activators of transcription", + "Stats" + ] + }, + { + "id": "10763", + "type": "gene", + "text": "Normal baseline ( day - 8 ) PC levels ( 86 and 89 % ) were markedly reduced in both patients at the time of VOD manifestation on day 20 and 40 , respectively ( 26 and 31 % ) .", + "entities": [] + }, + { + "id": "10764", + "type": "gene", + "text": "Concomitantly , the total cellular level of p21 increased severalfold via a posttranscriptional mechanism .", + "entities": [ + "p21" + ] + }, + { + "id": "10765", + "type": "gene", + "text": "Calves fed MCT - milk had significantly lower blood cholesterol than calves fed T - or SBO - milk .", + "entities": [] + }, + { + "id": "10766", + "type": "gene", + "text": "Plasma DHE concentration rose promptly above 5 ng / ml after the application of the PSA tape onto the damaged skin in hairless rat .", + "entities": [] + }, + { + "id": "10767", + "type": "gene", + "text": "The v - ets oncogene of the avian retrovirus E26 differs from its cellular progenitor p68c - ets - 1 by two amino acid substitutions ( alanine 285 and isoleucine 445 in c - ets - 1 both substituted by valine in v - ets , mutations A and B respectively ) and its carboxy - terminal end ( mutation C ) .", + "entities": [ + "v - ets oncogene", + "p68c - ets - 1", + "c - ets - 1", + "v - ets" + ] + }, + { + "id": "10768", + "type": "gene", + "text": "Escalation to 180 mg / m2 was to be carried out if white blood cell nadir count was > 2 . 0 x 10 ( 9 ) / l and platelet nadir count was > 75 x 10 ( 9 ) / l .", + "entities": [] + }, + { + "id": "10769", + "type": "gene", + "text": "Three patients had well - , 6 patients had moderately - , and 5 patients had poorly - differentiated adenocarcinoma of the prostate .", + "entities": [] + }, + { + "id": "10770", + "type": "gene", + "text": "Mice homozygous for the dlg mutation exhibit growth retardation in utero , have hypoplasia of the premaxilla and mandible , have a cleft secondary palate , and die perinatally .", + "entities": [ + "dlg" + ] + }, + { + "id": "10771", + "type": "gene", + "text": "An unexpected finding was the presence at position - 403 to - 385 of a putative dioxin responsive element , a sequence found to be responsible for the induction of transcription of the cytochrome P450IA1 gene ( CYPIA1 ) and other genes involved in detoxification / activation of polycyclic aromatic hydrocarbons .", + "entities": [ + "cytochrome P450IA1 gene", + "CYPIA1" + ] + }, + { + "id": "10772", + "type": "gene", + "text": "Full - length FLAP clones were isolated from a mouse skeletal muscle cDNA library .", + "entities": [ + "Full - length FLAP" + ] + }, + { + "id": "10773", + "type": "gene", + "text": "CONCLUSION : Twice daily treatment with inhaled fluticasone propionate 50 micrograms or 100 micrograms was significantly more effective than theophylline in the treatment of mild - to - moderate asthma .", + "entities": [] + }, + { + "id": "10774", + "type": "gene", + "text": "The defined length of the mRNA , 1 , 838 nucleotides , was in agreement with that of a 1 . 9 - kb RNA expressed throughout the replication cycle , starting at the early stages of infection .", + "entities": [] + }, + { + "id": "10775", + "type": "gene", + "text": "This dominant - negative effect of FRNK was reversed by a point mutation ( Leu - 1034 to Ser ) which prevented FRNK localization to focal contact sites .", + "entities": [ + "FRNK", + "FRNK" + ] + }, + { + "id": "10776", + "type": "gene", + "text": "Therefore , homozygous co - deletions of CDKN2A and CDKN2B rather than mutations targeting individual transcripts are frequently selected for in these tumors .", + "entities": [ + "CDKN2A", + "CDKN2B" + ] + }, + { + "id": "10777", + "type": "gene", + "text": "The ability of A20 to block NF - kappaB activation was mapped to its C - terminal zinc finger domain .", + "entities": [ + "A20", + "NF - kappaB" + ] + }, + { + "id": "10778", + "type": "gene", + "text": "Autorosette - forming cells are characterized by a high activity of alkaline and acid phosphatases and low NBT - test values .", + "entities": [ + "alkaline and acid phosphatases" + ] + }, + { + "id": "10779", + "type": "gene", + "text": "Complete sequences were obtained for the three large thrombic peptides , and these were aligned by using peptides from the V8 protease digest .", + "entities": [ + "V8 protease" + ] + }, + { + "id": "10780", + "type": "gene", + "text": "Intraventricular injection of ( 2S , 1 ' R , 2 ' R , 3 ' R ) - 2 - ( 2 , 3 - dicarboxycyclopropyl ) glycine ( DCG - IV ) , a potent agonist for metabotropic glutamate receptors , to rats retarded dose - dependently the recovery from halothane anesthesia at a dose range from 30 to 300 pmol / rat .", + "entities": [ + "glutamate receptors" + ] + }, + { + "id": "10781", + "type": "gene", + "text": "The method was adapted for the determination of nadolol racemate A by a change in mobile phase composition .", + "entities": [] + }, + { + "id": "10782", + "type": "gene", + "text": "Transfection analyses indicate that mutation of any one of these TGACCT motifs or truncation of the entire HD PPRE into a separate DR1 and DR2 element significantly reduced the transcriptional response of HD PPRE to peroxisome proliferators .", + "entities": [ + "HD", + "HD" + ] + }, + { + "id": "10783", + "type": "gene", + "text": "Role of superoxide dismutase in cellular oxidative processes and method of its determination in biological materials", + "entities": [ + "superoxide dismutase" + ] + }, + { + "id": "10784", + "type": "gene", + "text": "In contrast , extracts of the mutant virions catalyze the wild - type level of transcription from an exogenous template containing an early promoter .", + "entities": [] + }, + { + "id": "10785", + "type": "gene", + "text": "However , there were some properties of Rak that are distinct from Src - like kinases : ( a ) expression of Rak was predominantly in epithelial - derived cell lines and tissues , especially normal liver and kidney , and cell lines of breast and colon origin ; ( b ) Rak does not harbor the NH2 - terminal glycine essential for myristylation and membrane localization ; and ( c ) Rak possesses a putative bipartite nuclear localization signal in the SH2 domain , and subcellular fractionation studies revealed that p54rak resides predominantly in the nucleus .", + "entities": [ + "Rak", + "Src - like kinases", + "Rak", + "Rak", + "Rak", + "SH2 domain", + "p54rak" + ] + }, + { + "id": "10786", + "type": "gene", + "text": "Also , the EWS protein stimulates transcription mediated by the COOH - terminal transactivation domain of the cofactor CREB - binding protein ( CBP ) .", + "entities": [ + "EWS protein", + "CREB - binding protein", + "CBP" + ] + }, + { + "id": "10787", + "type": "gene", + "text": "6 .", + "entities": [] + }, + { + "id": "10788", + "type": "gene", + "text": "The mouse extracellular signal - regulated kinase 2 gene .", + "entities": [ + "extracellular signal - regulated kinase 2 gene" + ] + }, + { + "id": "10789", + "type": "gene", + "text": "Overexpression of ICBP90 in COS - 1 - transfected cells induced an enhanced expression of endogenous topoisomerase IIalpha .", + "entities": [ + "ICBP90", + "endogenous topoisomerase IIalpha" + ] + }, + { + "id": "10790", + "type": "gene", + "text": "Significantly higher lung function parameters were obtained in extubated recipients of LPD preserved grafts 2 weeks after TX .", + "entities": [] + }, + { + "id": "10791", + "type": "gene", + "text": "We did not detect p50 in association with native glucocorticoid receptor in L cells or with the overexpressed glucocorticoid receptor in Chinese hamster ovary cells .", + "entities": [ + "p50", + "native glucocorticoid receptor", + "glucocorticoid receptor" + ] + }, + { + "id": "10792", + "type": "gene", + "text": "The neglect of Richards ' s theory demonstrates the range of factors , other than the strictly scientific , which can be important in determining the influence or otherwise of a psychological theory .", + "entities": [] + }, + { + "id": "10793", + "type": "gene", + "text": "Damage to the BBB was judged by extravasation of Evans Blue ( EB ) dye , which was administered either 2 , 3 , 24 or 48 h after onset of MCAo .", + "entities": [] + }, + { + "id": "10794", + "type": "gene", + "text": "In ciliates , both mechanisms are readily observed .", + "entities": [] + }, + { + "id": "10795", + "type": "gene", + "text": "Takayasu ' s disease : association with HLA - B5 .", + "entities": [ + "HLA - B5" + ] + }, + { + "id": "10796", + "type": "gene", + "text": "Regressing microaneurysms in 5 cases of hepatitis B virus related polyarteritis nodosa .", + "entities": [] + }, + { + "id": "10797", + "type": "gene", + "text": "A picture is emerging showing a gradient of function among p53 , p73 , p63 ranging from tumor suppression to development .", + "entities": [ + "p53", + "p73", + "p63" + ] + }, + { + "id": "10798", + "type": "gene", + "text": "Furthermore , the NH2 - terminal portion of the homologue was not translocated into the outer membrane without its COOH - terminal part .", + "entities": [] + }, + { + "id": "10799", + "type": "gene", + "text": "Recombinant BRI1 - KD autophosphorylated on serine ( Ser ) and threonine ( Thr ) residues with p - Ser predominating .", + "entities": [ + "Recombinant BRI1 - KD" + ] + }, + { + "id": "10800", + "type": "gene", + "text": "RXR - gamma expression produced significant reduction in levels of RA - responsive genes including the cyclin - dependent kinase inhibitors p21Cip1 / WAF1 and p27Kip1 , resulting in increased cdc2 and cdk2 kinase activity and RB phosphorylation .", + "entities": [ + "RXR - gamma", + "cyclin - dependent kinase", + "p21Cip1", + "WAF1", + "p27Kip1", + "cdc2", + "cdk2 kinase", + "RB" + ] + }, + { + "id": "10801", + "type": "gene", + "text": "In contrast , overproduction of Der3p is lethal in a sec61 - 2 strain at the permissive temperature of 25 degrees C .", + "entities": [ + "Der3p", + "sec61 - 2" + ] + }, + { + "id": "10802", + "type": "gene", + "text": "Three large field placement errors ( two patients with 11 . 5 and 16 . 0 mm distances of the planned versus simulated isocenter , respectively and one patient with a 7 degree rotational error ) were detected and , as with the smaller errors , were immediately corrected .", + "entities": [] + }, + { + "id": "10803", + "type": "gene", + "text": "Methyl formate was used as the solvent of biodegradable oligoesters for the fabrication of microspheres with encapsulated bovine serum albumin ( BSA ) .", + "entities": [ + "bovine serum albumin", + "BSA" + ] + }, + { + "id": "10804", + "type": "gene", + "text": "Effects of dioxins on thyroid function in newborn babies .", + "entities": [] + }, + { + "id": "10805", + "type": "gene", + "text": "This analysis revealed an intact gene ( arg4 ) showing a high degree of homology with the Saccharomyces cerevisiae CPA2 gene encoding the large subunit of carbamoyl - phosphate synthetase ( CPS - A ) .", + "entities": [ + "arg4", + "Saccharomyces cerevisiae CPA2 gene", + "carbamoyl - phosphate synthetase", + "CPS - A" + ] + }, + { + "id": "10806", + "type": "gene", + "text": "These animals were viable and fertile .", + "entities": [] + }, + { + "id": "10807", + "type": "gene", + "text": "III .", + "entities": [] + }, + { + "id": "10808", + "type": "gene", + "text": "ORFK10 . 5 encodes a protein , latency - associated nuclear antigen 2 ( LANA2 ) , which is expressed in KSHV - infected hematopoietic tissues , including PEL and CD but not KS lesions .", + "entities": [ + "ORFK10 . 5", + "latency - associated nuclear antigen 2", + "LANA2" + ] + }, + { + "id": "10809", + "type": "gene", + "text": "Gel mobility shift and super - shift assays using liver nuclear extracts from either rat liver or DDT1MF - 2 cells demonstrated that the CRE in the alpha 1B - AR gene bound CRE binding protein .", + "entities": [ + "alpha 1B - AR gene", + "CRE binding protein" + ] + }, + { + "id": "10810", + "type": "gene", + "text": "Hepatitis B and C seroprevalence rates among high - risk adolescents are lower in El Paso than in other similar US populations , presenting an ideal climate for prevention programs .", + "entities": [] + }, + { + "id": "10811", + "type": "gene", + "text": "We have constructed , using synthetic DNA oligonucleotides , a U14 snRNA gene which has been positioned behind a T7 RNA polymerase promoter site and then inserted into a plasmid .", + "entities": [ + "U14 snRNA gene", + "T7 RNA polymerase promoter site" + ] + }, + { + "id": "10812", + "type": "gene", + "text": "Update on maternal - fetal infections by hepatitis C , HIV and cytomegalovirus", + "entities": [] + }, + { + "id": "10813", + "type": "gene", + "text": "A comparative study was undertaken between an enzymatic immunohistochemical technique ( EIT ) developed for the diagnosis of human trichinellosis and the indirect immunofluorescence test ( IIF ) , analysing sera from outbreaks of human trichinellosis in Argentina .", + "entities": [] + }, + { + "id": "10814", + "type": "gene", + "text": "Within - subject BP differences between fish oil and corn oil treatment were similar for Dinamap ( 3 . 2 + / - 1 . 8 / 2 . 5 + / - 1 . 0 mm Hg ) and for 24 - h ABP ( 2 . 5 + / - 1 . 0 / 2 . 3 + / - 0 . 8 mm Hg ) , but were more significant with the latter .", + "entities": [] + }, + { + "id": "10815", + "type": "gene", + "text": "At 1 , 5 , and 9 months after initial isolation of C . kutscheri from the oral cavity , hamsters were euthanatized , and attempts were made to culture C . kutscheri from 13 additional sites .", + "entities": [] + }, + { + "id": "10816", + "type": "gene", + "text": "Single - alanine - substitution mutations had minimal , if any , effects on S - induced cell - to - cell fusion .", + "entities": [] + }, + { + "id": "10817", + "type": "gene", + "text": "Progressive 100 - mmHg stepwise decreases in superfusate oxygen partial pressure ( PO2 ) from control ( 95 % O2 aeration , PO2 , 620 - 650 mmHg ) were produced , and subsequent changes in isometric active and resting tension were measured .", + "entities": [] + }, + { + "id": "10818", + "type": "gene", + "text": "In consequence , the gpI derived from cells infected with mO74 showed antigenic characteristics similar to those of gpI from VZV - infected cells as determined from the immunoprecipitation pattern , although the molecular weight of each polypeptide was different , and antibody produced in rabbits infected with recombinant virus had a high neutralizing activity , when the reaction was performed with complement .", + "entities": [ + "gpI", + "gpI" + ] + }, + { + "id": "10819", + "type": "gene", + "text": "Because ATF - 1 and CREM are known to bind to cAMP response elements ( CRE ) , this functional sequence was named the kappa E3 ' - CRE .", + "entities": [ + "ATF - 1", + "CREM", + "kappa E3 '" + ] + }, + { + "id": "10820", + "type": "gene", + "text": "We have measured the release of interleukin - 1 beta ( IL - 1 ) and tumour necrosis factor - alpha ( TNF ) by unstimulated monocytes and monocytes stimulated with lipopolysaccharide ( LPS ) isolated from the peripheral blood of two patients with acute poststreptococcal glomerulonephritis ( AGN ) and 16 healthy controls .", + "entities": [ + "interleukin - 1 beta", + "IL - 1", + "tumour necrosis factor - alpha", + "TNF" + ] + }, + { + "id": "10821", + "type": "gene", + "text": "Here we show that messenger RNAs encoding trans - sialidases containing the repeats are not present in epimastigotes but are abundant in trypomastigotes .", + "entities": [] + }, + { + "id": "10822", + "type": "gene", + "text": "Recent studies have demonstrated that Cbl , the 120 - kDa protein product of the c - cbl proto - oncogene , serves as a substrate of a number of receptor - coupled tyrosine kinases and forms complexes with SH3 and SH2 domain - containing proteins , pointing to its role in signal transduction .", + "entities": [ + "Cbl", + "c - cbl proto - oncogene", + "receptor - coupled tyrosine kinases", + "SH3", + "SH2" + ] + }, + { + "id": "10823", + "type": "gene", + "text": "THE SCALING OF SONG FREQUENCY IN CICADAS", + "entities": [] + }, + { + "id": "10824", + "type": "gene", + "text": "In both shoots and roots , GT - 2 protein is undetectable in meristematic tissue but becomes expressed at later stages of cellular development , consistent with a role in contributing to the pattern of phytochrome A gene expression .", + "entities": [ + "GT - 2 protein", + "phytochrome A gene" + ] + }, + { + "id": "10825", + "type": "gene", + "text": "Diagnostic value of adenosine deaminase activity in tuberculous effusions .", + "entities": [ + "adenosine deaminase" + ] + }, + { + "id": "10826", + "type": "gene", + "text": "Early infection was detected in one of 50 control women who gave birth to a healthy infant .", + "entities": [] + }, + { + "id": "10827", + "type": "gene", + "text": "Two families with concordant inheritance of DNAH9 alleles in affected individuals were observed .", + "entities": [ + "DNAH9 alleles" + ] + }, + { + "id": "10828", + "type": "gene", + "text": "Fas - resistant DT - 40 lymphoma B - cells rendered BTK - deficient through targeted disruption of the btk gene by homologous recombination knockout underwent apoptosis after Fas ligation , but wild - type DT - 40 cells or BTK - deficient DT - 40 cells reconstituted with wild - type human btk gene did not .", + "entities": [ + "Fas", + "BTK", + "btk gene", + "Fas", + "BTK", + "wild - type human btk gene" + ] + }, + { + "id": "10829", + "type": "gene", + "text": "Deletion mutagenesis demonstrated that these two elements are involved in the positive regulation of MLC - 2 gene transcription .", + "entities": [ + "MLC - 2 gene" + ] + }, + { + "id": "10830", + "type": "gene", + "text": "ELISA was found to make a contribution to the diagnosis of tuberculosis similar to that of sputum smear .", + "entities": [] + }, + { + "id": "10831", + "type": "gene", + "text": "NE and PR3 assist in the destruction of phagocytosed microorganisms , cleave the important connective - tissue protein elastin , and generate chemotactic activities by forming alpha 1 - proteinase inhibitor complexes and elastin peptides .", + "entities": [ + "NE", + "PR3", + "connective - tissue protein elastin", + "alpha 1 - proteinase inhibitor complexes", + "elastin peptides" + ] + }, + { + "id": "10832", + "type": "gene", + "text": "Relations between cellular electrical activity and cardiac mechanical activity in man , the dog and the rabbit", + "entities": [] + }, + { + "id": "10833", + "type": "gene", + "text": "Thus , the active - site mutation prevents the wild - type processing of the N - glycosylated 73 - kDa precursor of PrB to the 41 . 5 kDa pro - PrB in the endoplasmic reticulum .", + "entities": [ + "PrB", + "41 . 5 kDa pro - PrB" + ] + }, + { + "id": "10834", + "type": "gene", + "text": "AIDS - related disseminated histoplasmosis in San Francisco , California .", + "entities": [] + }, + { + "id": "10835", + "type": "gene", + "text": "The absence of other regions of hybridization suggests that there are no closely related sequences ( e . g . , reverse transcribed pseudogenes ) scattered throughout the genome and that if there are closely related genes , they must be clustered near GSTT2 .", + "entities": [ + "GSTT2" + ] + }, + { + "id": "10836", + "type": "gene", + "text": "A 5 . 3 - kb DNA fragment , which included the entire structural porin gene ( named porCa ) and its flanking regions , was identified .", + "entities": [ + "porin gene", + "porCa" + ] + }, + { + "id": "10837", + "type": "gene", + "text": "( 1997 ) Science 275 , 1927 - 1930 ) .", + "entities": [] + }, + { + "id": "10838", + "type": "gene", + "text": "These results suggest an increased risk of developing cancer among polyp patients and the possibility of prophylactic effect of polypectomy against subsequent cancer .", + "entities": [] + }, + { + "id": "10839", + "type": "gene", + "text": "The effects of contrast media on coagulation factor XII .", + "entities": [ + "coagulation factor XII" + ] + }, + { + "id": "10840", + "type": "gene", + "text": "The TTG - 2 gene has been identified at the site of chromosomal translocations in acute T - cell leukemia ' s ( T - ALL ) .", + "entities": [ + "TTG - 2 gene" + ] + }, + { + "id": "10841", + "type": "gene", + "text": "Curiously , testololactone was earlier and more widely used than aminoglutethimide in treating advanced breast carcinoma .", + "entities": [] + }, + { + "id": "10842", + "type": "gene", + "text": "The TA muscle was fatigued by four forms of repeated isometric contractions : ( 1 ) maximal voluntary contractions ( MVC ) , ( 2 ) MVC with circulation occluded , ( 3 ) electrically evoked contractions with 20 Hz supramaximal voltage stimulation and ( 4 ) electrically evoked contractions with circulation occluded .", + "entities": [] + }, + { + "id": "10843", + "type": "gene", + "text": "Delineating the molecular basis for agonist - induced destabilization of mRNA of G - protein - linked receptors that contributes to receptor down - regulation is fundamental to our understanding of long - term regulation of receptors by agonist .", + "entities": [ + "G - protein - linked receptors" + ] + }, + { + "id": "10844", + "type": "gene", + "text": "This technique was employed in 12 patients with a unicameral bone cyst .", + "entities": [] + }, + { + "id": "10845", + "type": "gene", + "text": "A set of peptides corresponding to the individual elements of secondary structure derived from the N - terminal domain of the ribosomal protein L9 have been synthesized .", + "entities": [ + "ribosomal protein L9" + ] + }, + { + "id": "10846", + "type": "gene", + "text": "The subjects from the two regions with a higher pollution level had lower FVC and FEV1 values than those from the Viskovo region .", + "entities": [] + }, + { + "id": "10847", + "type": "gene", + "text": "Together , these data identify ERK2 as a specific and direct target of HePTP and are consistent with a model in which HePTP negatively regulates ERK2 activity as part of a feedback mechanism .", + "entities": [ + "ERK2", + "HePTP", + "HePTP", + "ERK2" + ] + }, + { + "id": "10848", + "type": "gene", + "text": "( ii ) ICP27 binds preferentially to less modified forms of ICP4 , a protein that is extensively modified posttranslationally .", + "entities": [ + "ICP27", + "ICP4" + ] + }, + { + "id": "10849", + "type": "gene", + "text": "We have applied the mRNA differential display method to compare and analyze mRNAs prepared from five normal nasopharyngeal epithelial cell cultures and five nasopharyngeal carcinoma cell lines .", + "entities": [] + }, + { + "id": "10850", + "type": "gene", + "text": "SELECTION CRITERIA : Randomised controlled trials of cabergoline versus placebo in patients with a clinical diagnosis of idiopathic Parkinson ' s disease and long - term complications of levodopa therapy .", + "entities": [] + }, + { + "id": "10851", + "type": "gene", + "text": "All six genes were cloned and characterised .", + "entities": [] + }, + { + "id": "10852", + "type": "gene", + "text": "The lack of change in the ratio of the two spliced products expressed from either the normal or the 5 ' - rearranged myb further indicates that the insertion of the unique 121 amino acids in the larger myb transcripts is not a consequence of tumor - specific activation of the mouse myb oncogene .", + "entities": [ + "5 ' - rearranged myb", + "myb transcripts", + "mouse myb oncogene" + ] + }, + { + "id": "10853", + "type": "gene", + "text": "Thus , the absence of residual infarct - zone viability discriminates patients who develop progressive left ventricular dilation after reperfused AMI from those who maintain normal left ventricular geometry .", + "entities": [] + }, + { + "id": "10854", + "type": "gene", + "text": "Coexisting vertical and horizontal one and a half syndromes .", + "entities": [] + }, + { + "id": "10855", + "type": "gene", + "text": "Mutations in UPF1 lead to the selective stabilization of mRNAs containing early nonsense mutations without affecting the decay rates of most other mRNAs .", + "entities": [ + "UPF1" + ] + }, + { + "id": "10856", + "type": "gene", + "text": "In both these respects , however , the DBP mRNA resembles the late messengers of SV40 and polyoma viruses .", + "entities": [ + "DBP mRNA" + ] + }, + { + "id": "10857", + "type": "gene", + "text": "It applies Udry ' s biosocial perspective , which attempts to reconcile the biological and sociological models of premarital sexual and reproductive behaviour .", + "entities": [] + }, + { + "id": "10858", + "type": "gene", + "text": "METHODS : A population survey was undertaken in 10 , 148 individuals to measure the prevalence and identify the causes of blindness in Lebanon .", + "entities": [] + }, + { + "id": "10859", + "type": "gene", + "text": "No preferential VH / VL - chains correlated with any of the 12 different antigen reactivities , even for mAbs with nearly identical cross - reactivities .", + "entities": [ + "VH", + "VL" + ] + }, + { + "id": "10860", + "type": "gene", + "text": "Sequence and genetic organization of a Zymomonas mobilis gene cluster that encodes several enzymes of glucose metabolism .", + "entities": [] + }, + { + "id": "10861", + "type": "gene", + "text": "The 5 ' and 3 ' untranslated sequences contain characteristic sequences that are involved in the initiation and termination of transcription , including two possible promoters , one of which may contain two overlapping - 10 sequences .", + "entities": [] + }, + { + "id": "10862", + "type": "gene", + "text": "Consistent with this prediction , transfections into the hematopoietic cell line Jurkat showed a 9 . 0 - and 2 . 5 - fold activation of the mim - 1 promoter by the p32 and p30 isoforms , respectively .", + "entities": [ + "mim - 1 promoter", + "p32", + "p30 isoforms" + ] + }, + { + "id": "10863", + "type": "gene", + "text": "After a survey of the anatomical and physiological basis of operative treatment of behaviour disorders by stereotactic lesions in the amygdala and the posterior medial hypothalamus the author describes his own experiences with 603 operations for control of conservatively untreatable aggressiveness .", + "entities": [] + }, + { + "id": "10864", + "type": "gene", + "text": "DESIGN : A cross - sectional study .", + "entities": [] + }, + { + "id": "10865", + "type": "gene", + "text": "Only one DC cardioversion was required in the HBS group , whereas 2 DC in the CBC group and total 7 DC in the GIK group .", + "entities": [] + }, + { + "id": "10866", + "type": "gene", + "text": "Our data suggest that it may be possible to individualize hCG administration at midcycle by determining the number of follicles greater than 1 cm by ultrasound on cycle day 12 or 13 and giving hCG when serum E2 levels reach 1100 to 1200 pmol / l per follicle .", + "entities": [ + "hCG", + "hCG" + ] + }, + { + "id": "10867", + "type": "gene", + "text": "Inhibition assays performed with over 30 different natural and synthetic sialylated and / or sulfated compounds are utilized to define in greater detail specific structural features involved in oligosaccharide - protein binding .", + "entities": [] + }, + { + "id": "10868", + "type": "gene", + "text": "Treatment of meat muscle 800 V for 45 s reduced weeping but increased slightly the rate of autoxidation of lipids .", + "entities": [] + }, + { + "id": "10869", + "type": "gene", + "text": "Northern blot hybridization demonstrated that HEP - COP was expressed in a wide range of human adult and fetal tissues .", + "entities": [ + "HEP", + "COP" + ] + }, + { + "id": "10870", + "type": "gene", + "text": "Molecule ( s ) secreted by neuronal cultures contribute to this induction of GLT - 1 , but little is known about the signaling pathways mediating this regulation .", + "entities": [ + "GLT - 1" + ] + }, + { + "id": "10871", + "type": "gene", + "text": "We have measured the kinetics of the recovery of mRNA synthesis in the inducible GAL10 and RNR3 genes after exposure of yeast cells to ultraviolet ( UV ) radiation .", + "entities": [ + "GAL10", + "RNR3 genes" + ] + }, + { + "id": "10872", + "type": "gene", + "text": "MED1 has a weak glycosylase activity on the mutagenic adduct 3 , N ( 4 ) - ethenocytosine , a metabolite of vinyl chloride and ethyl carbamate .", + "entities": [ + "MED1", + "glycosylase" + ] + }, + { + "id": "10873", + "type": "gene", + "text": "Deletion of an intergenic DNA - binding site for this complex from a human beta - globin locus construct results in delayed human gamma - to beta - globin switching in transgenic mice , suggesting that the PYR complex acts to facilitate the switch .", + "entities": [ + "human beta - globin locus construct", + "human gamma - to beta - globin", + "PYR complex" + ] + }, + { + "id": "10874", + "type": "gene", + "text": "The mRNA was converted to cDNA and amplified by the polymerase chain reaction technique .", + "entities": [] + }, + { + "id": "10875", + "type": "gene", + "text": "Our results , however , were obtained for Z itself and not for [ Z ] .", + "entities": [] + }, + { + "id": "10876", + "type": "gene", + "text": "The R2 region within the class I enhancer acts as a negative element in Ad12 - transformed cells and exhibits a stronger binding activity than is observed in nontumorigenic Ad5 - transformed cells , which are not reduced in class I expression .", + "entities": [] + }, + { + "id": "10877", + "type": "gene", + "text": "Elimination of the inducible response requires simultaneous mutation of both sequences , however , in the presence of an intact EpRE the upstream AP - 1 site is irrelevant to induction .", + "entities": [ + "AP - 1 site" + ] + }, + { + "id": "10878", + "type": "gene", + "text": "RESULTS : Abnormal color perception was found in 32 % of the epilepsy patients treated with vigabatrin monotherapy and 28 % of the epilepsy patients treated with carbamazepine monotherapy .", + "entities": [] + }, + { + "id": "10879", + "type": "gene", + "text": "The gene pairs psbB - psbT and psbH - psbN are cotranscribed from opposite strands .", + "entities": [ + "psbB", + "psbT", + "psbH", + "psbN" + ] + }, + { + "id": "10880", + "type": "gene", + "text": "Myocardial perfusion was evaluated using the enhanced gray level after contrast injection , and the level was compared with the morphology and degree of collateral development .", + "entities": [] + }, + { + "id": "10881", + "type": "gene", + "text": "These offspring of the alpha - MSH treated mothers were less sensitive to pain and as adults showed a reduced analgesic response to morphine .", + "entities": [ + "alpha - MSH" + ] + }, + { + "id": "10882", + "type": "gene", + "text": "Each sample was analysed as soon as possible , and repeated 15 , 30 , 60 and 120 min after sampling .", + "entities": [] + }, + { + "id": "10883", + "type": "gene", + "text": "In the electrophoresis mobility shift assay using nuclear extracts of the myogenic cells , MyoD and myogenin bound to the right E - box in the enhancer region of the MCK gene even in the presence of BMP - 2 .", + "entities": [ + "MyoD", + "myogenin", + "MCK gene", + "BMP - 2" + ] + }, + { + "id": "10884", + "type": "gene", + "text": "Composites as restoration materials", + "entities": [] + }, + { + "id": "10885", + "type": "gene", + "text": "From an RNK - 16 lambda - gt11 library , we have isolated and sequenced a novel cDNA rat NK cell protease 1 ( RNKP - 1 ) that has characteristics unique to serine proteases .", + "entities": [ + "rat NK cell protease 1", + "RNKP - 1", + "serine proteases" + ] + }, + { + "id": "10886", + "type": "gene", + "text": "These data establish Smd1p as a required component of the cellular splicing apparatus and a factor in snRNA maturation and stability .", + "entities": [ + "Smd1p" + ] + }, + { + "id": "10887", + "type": "gene", + "text": "Patients with CF and meconium ileus presented a poor nutritional status at diagnosis and a lower survival rate compared to the general CF population .", + "entities": [] + }, + { + "id": "10888", + "type": "gene", + "text": "In contrast , c - Src activated by isoproterenol led to tyrosine phosphorylation of Shc and subsequent Erk activation , but not tyrosine phosphorylation of cortactin or Stat3 .", + "entities": [ + "c - Src", + "Shc", + "Erk", + "cortactin", + "Stat3" + ] + }, + { + "id": "10889", + "type": "gene", + "text": "However , using ATL - 16T nuclear extract , we demonstrated that GATA - 4 is the only GATA - binding protein that forms specific DNA - protein complex with the - 70 GATA site .", + "entities": [ + "GATA - 4", + "GATA - binding protein" + ] + }, + { + "id": "10890", + "type": "gene", + "text": "CONCLUSIONS : The mechanism of MIRI is Qi deficiency and blood stasis in TCM , its treating principles should be promoting Qi and removing the blood stasis .", + "entities": [] + }, + { + "id": "10891", + "type": "gene", + "text": "Transvenous serial xeroradiography .", + "entities": [] + }, + { + "id": "10892", + "type": "gene", + "text": "The coding region of mkh1 is contained within a single exon encoding a 1 , 116 - amino - acid protein .", + "entities": [ + "mkh1" + ] + }, + { + "id": "10893", + "type": "gene", + "text": "Contrary to 1 , 8 - dihydroxy - 9 - anthrone , 1 , 8 , 9 - triacetoxyanthracene and 1 , 8 - diacetoxy - 9 - anthrone are effective against psoriatic lesions without accompanying inflammations of the skin .", + "entities": [] + }, + { + "id": "10894", + "type": "gene", + "text": "Serological studies at the early relapse stage of this disease showed increased serum ANA , IgA and IgM level with normal IgG and decrease of C3 and C4 .", + "entities": [ + "serum ANA", + "IgA", + "IgM", + "IgG", + "C3", + "C4" + ] + }, + { + "id": "10895", + "type": "gene", + "text": "Transfection with a CSF - 1R expression plasmid permitted CSF - 1 - dependent activation of the signalling pathway targeting an Ets / AP1 ( activator protein 1 ) element in the uPA promoter that has been shown previously to be a target of oncogenic ras and protein kinase C pathways .", + "entities": [ + "CSF - 1R", + "CSF - 1", + "Ets", + "AP1", + "activator protein 1", + "uPA promoter", + "oncogenic ras" + ] + }, + { + "id": "10896", + "type": "gene", + "text": "Neither the p42 / 44 nor the JNK pathway was involved in the action of IL - 1beta .", + "entities": [ + "p42 / 44", + "JNK", + "IL - 1beta" + ] + }, + { + "id": "10897", + "type": "gene", + "text": "After hepatitis B vaccine immunization , serum antibody response was of primary type in 33 cases with anti - HBs less than 2 . 1 S / N ( S / N Ratio Unit ) at T0 , the anti - HBs positive rate was 39 . 4 % , 84 . 8 % , 96 . 7 % and 96 . 7 % in T1 , T2 , T0 and T12 respectively .", + "entities": [ + "anti - HBs", + "anti - HBs" + ] + }, + { + "id": "10898", + "type": "gene", + "text": "ULKs and UNC - 51 share a typical domain structure of an amino - terminal kinase domain , a central proline / serine rich ( PS ) domain , and a carboxy - terminal ( C ) domain .", + "entities": [ + "ULKs", + "UNC - 51" + ] + }, + { + "id": "10899", + "type": "gene", + "text": "Histogenetic aspects of mesoblastic nephroma .", + "entities": [] + }, + { + "id": "10900", + "type": "gene", + "text": "To dissect these mechanisms , wild - type and mutant Raf - 1 proteins were studied in an in vitro system with purified plasma membranes from v - Ras - and v - Src - transformed cells ( transformed membranes ) .", + "entities": [ + "mutant Raf - 1 proteins", + "v - Ras", + "v - Src" + ] + }, + { + "id": "10901", + "type": "gene", + "text": "Interestingly , the IR5 ORF of EHV - 1 possesses a sequence of 13 amino acids ( CAYWCCLGHAFAC ) that is a perfect match to the consensus zinc finger motif ( C - X2 - 4 - C - X2 - 15 - C / H - X2 - 4 - C / H ) .", + "entities": [ + "IR5 ORF" + ] + }, + { + "id": "10902", + "type": "gene", + "text": "The introns are 1 . 6 - 1 . 9 kbp long .", + "entities": [] + }, + { + "id": "10903", + "type": "gene", + "text": "In 3 treatments the diet was supplemented with 0 , 100 and 150 mg probiotic / kg food .", + "entities": [] + }, + { + "id": "10904", + "type": "gene", + "text": "Since general regulatory factor I ( GRFI ) / repressor / activator site binding protein 1 ( RAP1 ) / translation upstream factor ( TUF ) is believed to be an activator of MAT alpha expression , we examined whether PYK1 , which is known to be regulated by GRFI / RAP1 / TUF , is also affected by the gal11 mutation .", + "entities": [ + "general regulatory factor I", + "GRFI", + "repressor / activator site binding protein 1", + "RAP1", + "translation upstream factor", + "TUF", + "MAT alpha", + "PYK1", + "GRFI", + "RAP1", + "TUF", + "gal11 mutation" + ] + }, + { + "id": "10905", + "type": "gene", + "text": "Two independent promoters as well as 5 ' untranslated regions regulate Dd ras expression in Dictyostelium .", + "entities": [ + "Dd ras" + ] + }, + { + "id": "10906", + "type": "gene", + "text": "In this study 26 patients ( 20 females and 6 males ) were evaluated .", + "entities": [] + }, + { + "id": "10907", + "type": "gene", + "text": "Mutational analysis of the P2 - proximal CTCF binding site and transient - cotransfection experiments demonstrate that CTCF is a transcriptional repressor of the human c - myc gene .", + "entities": [ + "P2 - proximal CTCF binding site", + "CTCF", + "human c - myc gene" + ] + }, + { + "id": "10908", + "type": "gene", + "text": "The location of multiple GRK2 and GRK5 phosphoacceptor sites at the extreme carboxyl terminus of the beta2AR is highly reminiscent of GRK1 - mediated phosphorylation of rhodopsin .", + "entities": [ + "GRK2", + "GRK5 phosphoacceptor sites", + "beta2AR", + "GRK1", + "rhodopsin" + ] + }, + { + "id": "10909", + "type": "gene", + "text": "Yusuf Dawood Docrat L . R . C . P .", + "entities": [] + }, + { + "id": "10910", + "type": "gene", + "text": "In the further development of bladder neck suspension according to Stamey - Pereyra , the use of miniature bone anchors received considerable support .", + "entities": [] + }, + { + "id": "10911", + "type": "gene", + "text": "The authors describe the technique of transverse axial tomography of the spine and give a detailed description of the axial anatomy of the normal lumbar spine from L - 4 to the sacrum .", + "entities": [] + }, + { + "id": "10912", + "type": "gene", + "text": "Inactivation of p53 but not p73 by adenovirus type 5 E1B 55 - kilodalton and E4 34 - kilodalton oncoproteins .", + "entities": [ + "p53", + "p73", + "adenovirus type 5 E1B 55 - kilodalton and E4 34 - kilodalton oncoproteins" + ] + }, + { + "id": "10913", + "type": "gene", + "text": "The intracoronary administration of both drugs markedly reduced the incidence of VF induced by the release of a 40 - min coronary artery occlusion .", + "entities": [] + }, + { + "id": "10914", + "type": "gene", + "text": "Mutagenesis of each NRF - 1 motif in the ALAS promoter gave substantially lowered levels of chloramphenicol acetyltransferase expression , whereas mutagenesis of both NRF - 1 motifs resulted in the almost complete loss of expression .", + "entities": [ + "NRF - 1 motif", + "ALAS promoter", + "chloramphenicol acetyltransferase", + "NRF - 1 motifs" + ] + }, + { + "id": "10915", + "type": "gene", + "text": "The assessment using 7 H 9 liquid medium by the former author demonstrated the potent activities of both CS - 940 * and sparfloxacin ( SPFX ) , followed by AM - 1155 * , ciprofloxacin ( CPFX ) , levofloxacin ( LVFX ) , OPC - 17116 * , NM - 394 * in sequence .", + "entities": [] + }, + { + "id": "10916", + "type": "gene", + "text": "Identification and structure of the Marek ' s disease virus serotype 2 glycoprotein M gene : comparison with glycoprotein M genes of Herpesviridae family .", + "entities": [ + "Marek ' s disease virus serotype 2 glycoprotein M gene", + "glycoprotein M genes" + ] + }, + { + "id": "10917", + "type": "gene", + "text": "Basal plasma renin activity ( PRA ) was slightly raised prior to training ( P < 0 . 07 ) compared to the controls and post - training .", + "entities": [ + "renin" + ] + }, + { + "id": "10918", + "type": "gene", + "text": "Canadian survey reveals widespread dissatisfaction among physicians .", + "entities": [] + }, + { + "id": "10919", + "type": "gene", + "text": "During exercise K + is released from contracting muscle and plasma K + concentration rises .", + "entities": [] + }, + { + "id": "10920", + "type": "gene", + "text": "From transient expression studies , we could demonstrate that the SH3 domain of PLC - gamma1 is necessary for the association with SOS1 in vivo .", + "entities": [ + "SH3 domain", + "PLC - gamma1", + "SOS1" + ] + }, + { + "id": "10921", + "type": "gene", + "text": "The Saccharomyces cerevisiae spindle pole body duplication gene MPS1 is part of a mitotic checkpoint .", + "entities": [ + "gene MPS1" + ] + }, + { + "id": "10922", + "type": "gene", + "text": "D .", + "entities": [] + }, + { + "id": "10923", + "type": "gene", + "text": "The predominant sensitizing allergens in Swedish asthmatic children are furred pet animals .", + "entities": [] + }, + { + "id": "10924", + "type": "gene", + "text": "As control , the cells were transfected with DNA mixtures containing vector mU6 - C1 or mU6 - C2 .", + "entities": [] + }, + { + "id": "10925", + "type": "gene", + "text": "To investigate the molecular mechanisms of this Tax - mediated inhibition , we analyzed its effect on the transcriptional activity of the myogenic MyoD protein , which was used as a paradigm of bHLH factors .", + "entities": [ + "Tax", + "MyoD protein", + "bHLH factors" + ] + }, + { + "id": "10926", + "type": "gene", + "text": "Furthermore , cpxA * mutations suppress the toxicity conferred by the LamB - LacZ hybrid protein , which exerts its effects in the cytoplasm , sequestered from DegP .", + "entities": [ + "cpxA *", + "LamB", + "LacZ", + "DegP" + ] + }, + { + "id": "10927", + "type": "gene", + "text": "This study was performed to clarify the location of a transesophageal echocardiographic ( TEE ) transducer when obtaining the short - axis view of the left ventricle ( S - LV ) .", + "entities": [] + }, + { + "id": "10928", + "type": "gene", + "text": "74 , 193 - 197 ) .", + "entities": [] + }, + { + "id": "10929", + "type": "gene", + "text": "After PTCA , ejection fraction increased from 54 + / - 8 % to 59 + / - 8 % ( p less than 0 . 05 ) and regional function improved significantly ( maximal standard deviation before PTCA : 2 . 8 + / - 0 . 8 ; after PTCA : 1 . 9 + / - 0 . 9 - segments below the first standard deviation before PTCA : 31 + / - 16 ; after PTCA : 19 + / - 17 ) .", + "entities": [] + }, + { + "id": "10930", + "type": "gene", + "text": "In vitro studies with blood cells incubated with acetate or bicarbonate ions in concentrations , which are observed in vivo during hemodialysis , suggest that probably these ions do not directly affect superoxide anions generation , erythrocyte SOD - 1 and catalase activities and erythrocyte membrane lipid peroxidation .", + "entities": [ + "SOD - 1", + "catalase" + ] + }, + { + "id": "10931", + "type": "gene", + "text": "Furthermore , freezing in the presence of bovine lactalbumin resulted in a good maintenance of the cellular viability and of the CCCD heterogeneity in respect to fresh cells .", + "entities": [ + "bovine lactalbumin" + ] + }, + { + "id": "10932", + "type": "gene", + "text": "Vacuum Rabi splitting as a feature of linear - dispersion theory : Analysis and experimental observations .", + "entities": [] + }, + { + "id": "10933", + "type": "gene", + "text": "This review summarizes the clinical evidence to support current therapies in irritable bowel syndrome ( IBS ) .", + "entities": [] + }, + { + "id": "10934", + "type": "gene", + "text": "Teratological study of etoperidone in the rat and rabbit .", + "entities": [] + }, + { + "id": "10935", + "type": "gene", + "text": "Therefore , it would be advantageous to identify such persons and treat them preferentially .", + "entities": [] + }, + { + "id": "10936", + "type": "gene", + "text": "Third - and later - parity cows were randomly assigned after each parturition to Charolais and Red Poll bulls in multiple - sire pastures .", + "entities": [] + }, + { + "id": "10937", + "type": "gene", + "text": "To investigate the mechanisms involved in the transcriptional control of retinoid X receptor ( RXR ) gene expression , the 5 ' - flanking region of the human RXRgamma2 isoform was characterized .", + "entities": [ + "retinoid X receptor", + "RXR", + "human RXRgamma2 isoform" + ] + }, + { + "id": "10938", + "type": "gene", + "text": "These include the CACCC and CAAT motifs .", + "entities": [] + }, + { + "id": "10939", + "type": "gene", + "text": "The present study was designed to evaluate the sensitivity and specificity of AMP CT ( Gen - Probe Incorporated , San Diego , CA , USA ) on urogenital specimens taken from symptomatic patients and on first void urine ( FVU ) specimens from asymptomatic patients .", + "entities": [] + }, + { + "id": "10940", + "type": "gene", + "text": "Therefore , we propose that p27 represents a crucial molecule in HMBA signaling that cannot be replaced by p21 .", + "entities": [ + "p27", + "p21" + ] + }, + { + "id": "10941", + "type": "gene", + "text": "The debate over electives - - 1899 .", + "entities": [] + }, + { + "id": "10942", + "type": "gene", + "text": "Two differentially expressed LNX messages encode overlapping proteins with predicted molecular masses of 80 kDa ( LNX ) and 70 kDa ( LNX - b ) .", + "entities": [ + "LNX messages", + "80 kDa ( LNX )", + "70 kDa ( LNX - b )" + ] + }, + { + "id": "10943", + "type": "gene", + "text": "The application of ISH and IHC did not change significantly the routine histologic classification of pneumonias into CMV - IP and IIP .", + "entities": [] + }, + { + "id": "10944", + "type": "gene", + "text": "A decrease of erythrocyte Mn with age , expressed in nmol / L , was noted ( p < 0 . 02 ) .", + "entities": [] + }, + { + "id": "10945", + "type": "gene", + "text": "No differences in fixation quality were observed between cochleas fixed by intravascular perfusion and cochleas fixed by intralabyrinthine perfusion .", + "entities": [] + }, + { + "id": "10946", + "type": "gene", + "text": "We show that p73 can transcriptionally inhibit a number of cellular and viral promoters .", + "entities": [ + "p73" + ] + }, + { + "id": "10947", + "type": "gene", + "text": "In transient analysis using particle bombardment of tobacco leaf sections , a tetramer of the distB ABRE ( abscisic acid - responsive element ) mediated transactivation by ABI3 and ABI3 - dependent response to ABA , whereas a tetramer of the composite RY / G complex , containing RY repeats and a G - box , mediated only ABA - independent transactivation by ABI3 .", + "entities": [ + "ABI3", + "ABI3", + "ABI3" + ] + }, + { + "id": "10948", + "type": "gene", + "text": "Underestimations by as much as 35 % may occur due to the problems in the existing methodologies .", + "entities": [] + }, + { + "id": "10949", + "type": "gene", + "text": "A total of 25 patients with malignant brain tumours were investigated .", + "entities": [] + }, + { + "id": "10950", + "type": "gene", + "text": "Chem . , 270 : 7117 - 7124 , 1995 ; and MT Hartsough et al . , J .", + "entities": [] + }, + { + "id": "10951", + "type": "gene", + "text": "A rare chronic course of Budd - Chiari syndrome associated with thrombosis of the portal vein was observed in a 30 - year - old male patient suffering from postmyocarditic cardiosclerosis .", + "entities": [] + }, + { + "id": "10952", + "type": "gene", + "text": "We report the identification and characterization of myr 4 ( myosin from rat ) , the first mammalian myosin I that is not closely related to brush border myosin I .", + "entities": [ + "myr 4", + "myosin from rat", + "mammalian myosin I", + "myosin I" + ] + }, + { + "id": "10953", + "type": "gene", + "text": "A review of the literature identified 8 comprehensive clinical studies , all of which failed to document any relationship between NF1 and intracranial aneurysms .", + "entities": [ + "NF1" + ] + }, + { + "id": "10954", + "type": "gene", + "text": "The deduced amino acid sequence exhibited 98 % identity to the human cellular transglutaminase sequence .", + "entities": [] + }, + { + "id": "10955", + "type": "gene", + "text": "J .", + "entities": [] + }, + { + "id": "10956", + "type": "gene", + "text": "A new species of Euspondylus is described based on a female ( taken within a bromeliad ) from Cerro El Humo , Sucre , northeastern Venezuela .", + "entities": [] + }, + { + "id": "10957", + "type": "gene", + "text": "Expression of a novel murine phospholipase D homolog coincides with late neuronal development in the forebrain .", + "entities": [ + "murine phospholipase D homolog" + ] + }, + { + "id": "10958", + "type": "gene", + "text": "( iii ) The mRNA is not efficiently polyadenylated at sequences in the 3 ' end of the DHFR cDNA but rather uses polyadenylation signals downstream from the DHFR cDNA .", + "entities": [ + "DHFR cDNA", + "DHFR cDNA" + ] + }, + { + "id": "10959", + "type": "gene", + "text": "The glomerular filtration rate and effective renal plasma flow were determined by a standard clearance method , employing continuous infusion of inulin and para - aminohippuric acid .", + "entities": [] + }, + { + "id": "10960", + "type": "gene", + "text": "Moreover , a recombinant Ad expressing Ad5 E4orf6 / 7 induced apoptosis in rat cells when coinfected with wild - type p53 - expressing Ad .", + "entities": [ + "Ad5 E4orf6 / 7", + "p53" + ] + }, + { + "id": "10961", + "type": "gene", + "text": "Dosimetric estimates for these organs were 2 . 3 + / - 1 . 1 and 2 . 3 + / - 1 . 4 rad ( . 02 + / - . 01 Gy ) , respectively , with a whole - body estimate of 0 . 28 rad ( . 003 Gy ) .", + "entities": [] + }, + { + "id": "10962", + "type": "gene", + "text": "Only two of 27 participants ( 7 . 4 % ) with definite POAG had been previously diagnosed and treated , and 66 . 7 % of the previously undiagnosed had IOP less than 22 mmHg .", + "entities": [] + }, + { + "id": "10963", + "type": "gene", + "text": "The PAI - 2 gene is one of the most TNF - responsive genes known and is also highly induced by the phorbol ester phorbol 12 - myristate 13 - acetate ( PMA ) and the phosphatase inhibitor , okadaic acid , in both HT - 1080 fibrosarcoma and U - 937 histiocytic cells .", + "entities": [ + "PAI - 2 gene", + "TNF - responsive genes" + ] + }, + { + "id": "10964", + "type": "gene", + "text": "Secretion of interleukin - 8 , RANTES , macrophage inflammatory protein 1alpha , and 10 - kappaDa IFN - gamma - inducible protein were increased in differentiating keratinocytes by E6 .", + "entities": [ + "interleukin - 8", + "RANTES", + "macrophage inflammatory protein 1alpha", + "10 - kappaDa IFN - gamma - inducible protein", + "E6" + ] + }, + { + "id": "10965", + "type": "gene", + "text": "The preferences were for intact vis - a - vis castrated males , though injections of TP restored the castrates ' attractiveness to the females .", + "entities": [] + }, + { + "id": "10966", + "type": "gene", + "text": "DESIGN : Prospective , randomized , double - blind , controlled trial .", + "entities": [] + }, + { + "id": "10967", + "type": "gene", + "text": "The physical and chemical stability of a combination of drugs commonly administered into the epidural or intrathecal space for the treatment of chronic pain was investigated .", + "entities": [] + }, + { + "id": "10968", + "type": "gene", + "text": "Together , these data suggest that the carboxyl terminus of CFTR contains a tyrosine - based internalization signal that interacts with the endocytic adaptor complex AP - 2 to facilitate efficient entry of CFTR into clathrin - coated vesicles .", + "entities": [ + "CFTR", + "AP - 2", + "CFTR", + "clathrin" + ] + }, + { + "id": "10969", + "type": "gene", + "text": "Role of the infectious - disease specialist of a polyclinic in reducing the incidence of communicable diseases", + "entities": [] + }, + { + "id": "10970", + "type": "gene", + "text": "From these results , it is concluded that EDLF has clear vasoconstrictor properties which are not due to adrenergic or calcium entry mechanisms and that there are differences in the vasoconstrictor effects of EDLFs with respect to different vascular beds .", + "entities": [] + }, + { + "id": "10971", + "type": "gene", + "text": "A 5 . 8S - like structure is present within the 5 ' - terminal region of all three fungal mitochondrial LSU rRNAs ; in contrast , no 4 . 5S - like structure is evident at the 3 ' end of these molecules .", + "entities": [ + "5 . 8S - like structure", + "fungal mitochondrial LSU rRNAs", + "4 . 5S - like structure" + ] + }, + { + "id": "10972", + "type": "gene", + "text": "Scapulae with a Type I configuration were found to have low values for the coraco - glenoid angle and coracoid overlap , which are known to be associated with a short coraco - humeral distance .", + "entities": [] + }, + { + "id": "10973", + "type": "gene", + "text": "Age > / = 50 years ( odds ratio [ OR ] , 14 . 1 ) , BMI > / = 28 kg / m ( 2 ) ( OR , 5 . 7 ) , triglycerides > / = 1 . 7 mmol / L ( OR , 5 ) , and alanine aminotransferase ( ALT ) > / = 2N ( OR , 4 . 6 ) were independently associated with septal fibrosis .", + "entities": [ + "alanine aminotransferase", + "ALT" + ] + }, + { + "id": "10974", + "type": "gene", + "text": "Adding 10 mmol SDS / l led to transient inhibition of acidification , metal solubilization and sulfur oxidation .", + "entities": [] + }, + { + "id": "10975", + "type": "gene", + "text": "Virol .", + "entities": [] + }, + { + "id": "10976", + "type": "gene", + "text": "A Chinese ( HK ) SF - 36 survey form was developed by an iterative translation process .", + "entities": [] + }, + { + "id": "10977", + "type": "gene", + "text": "Studies of MPO gene regulation can help to elucidate the mechanism of normal and abnormal myeloid differentiation .", + "entities": [ + "MPO gene" + ] + }, + { + "id": "10978", + "type": "gene", + "text": "The predicted receptor structure includes a cysteine - rich extracellular domain , a single hydrophobic transmembrane domain , and a predicted cytoplasmic serine / threonine kinase domain .", + "entities": [ + "cytoplasmic serine / threonine kinase domain" + ] + }, + { + "id": "10979", + "type": "gene", + "text": "In particular , the potential for prostate cancer chemoprevention using nonsteroidal anti - inflammatory drugs ( cyclo - oxygenase inhibitors ; NSAIDs ) has received little attention .", + "entities": [ + "cyclo - oxygenase" + ] + }, + { + "id": "10980", + "type": "gene", + "text": "Rigid point feature registration using mutual information .", + "entities": [] + }, + { + "id": "10981", + "type": "gene", + "text": "Some studies of exercise have associated beta - endorphin release with increased exertion levels , but other evidence suggests that acidosis may stimulate the release of beta - endorphin .", + "entities": [ + "beta - endorphin", + "beta - endorphin" + ] + }, + { + "id": "10982", + "type": "gene", + "text": "We detected mos transcripts by Northern ( RNA ) analyses in RNA prepared from chicken and quail ovaries and testes .", + "entities": [ + "mos transcripts" + ] + }, + { + "id": "10983", + "type": "gene", + "text": "Fasting gastrin levels ( normal range : 25 - 110 mU / L ) varied from 48 . 78 mU / L - 168 . 20 ( mean : 85 . 23 mU / L ) .", + "entities": [ + "gastrin" + ] + }, + { + "id": "10984", + "type": "gene", + "text": "The intron is capable of splicing despite the fact that both the EBS1 / IBS1 and the EBS2 / IBS2 sequence motifs , thought to be necessary for correct splicing , extend over 5 instead of 6 bp .", + "entities": [ + "EBS1", + "IBS1", + "EBS2", + "IBS2" + ] + }, + { + "id": "10985", + "type": "gene", + "text": "Tih1 maps to distal mouse Chr 1 and human Chr 1q31 , chromosomal regions that have not shown evidence for imprinting and , in contrast to Ipl , Tih1 is expressed equally from both parental alleles .", + "entities": [ + "Tih1", + "Ipl", + "Tih1" + ] + }, + { + "id": "10986", + "type": "gene", + "text": "The cloned alcR gene provided in trans restored these siderophore system activities to the mutants .", + "entities": [ + "alcR gene" + ] + }, + { + "id": "10987", + "type": "gene", + "text": "The cloned alcR gene provided in trans restored these siderophore system activities to the mutants .", + "entities": [ + "alcR gene" + ] + }, + { + "id": "10988", + "type": "gene", + "text": "Hyaluronan treatment stimulated collagen remodeling in the peripheral region and inhibited swelling of the meniscus repaired in the inner region .", + "entities": [ + "collagen" + ] + }, + { + "id": "10989", + "type": "gene", + "text": "Thalamotomy aiming at the CM - Pf complex and using stereotactic gamma irradiation has been performed in a series of 52 patients with severe pain due to malignancy .", + "entities": [] + }, + { + "id": "10990", + "type": "gene", + "text": "After the first cycle , 18 cases were treated at dose level 1 , after a second cycle , 13 cases were treated at dose level 2 .", + "entities": [] + }, + { + "id": "10991", + "type": "gene", + "text": "This protein encoded by this cDNA , which we have termed p150TSP ( for TPR - containing , SH2 - binding phosphoprotein ) , is located predominantly in the nucleus and is highly conserved in evolution .", + "entities": [ + "p150TSP", + "SH2 - binding phosphoprotein" + ] + }, + { + "id": "10992", + "type": "gene", + "text": "The cloning of PTR2 represents the first example of the molecular genetic characterization of a eucaryotic peptide transport gene .", + "entities": [ + "PTR2" + ] + }, + { + "id": "10993", + "type": "gene", + "text": "Activity of palgD in the cysB mutant , in CHA and in the non - mucoid strain PAO was assessed by the use of a transcriptional algD - xylE fusion .", + "entities": [ + "palgD", + "cysB mutant", + "algD", + "xylE" + ] + }, + { + "id": "10994", + "type": "gene", + "text": "OBJECTIVE : This study was conducted to assess the relative roles of 99mTc - sestamibi scintimammography and sonography in the evaluation of breast lesions that are indeterminate or suspicious on mammography or clinical examination .", + "entities": [] + }, + { + "id": "10995", + "type": "gene", + "text": "The 9 ; 22 chromosomal translocation characteristic of CML results in a fused bcr / abl gene and an abnormal fusion protein , p210bcr / abl .", + "entities": [ + "bcr", + "abl", + "p210bcr", + "abl" + ] + }, + { + "id": "10996", + "type": "gene", + "text": "The neurohypophysial vasopressin and oxytocin content was bioassayed by pressor effect following Dekanski or milk - ejection activity in vitro following van Dongen and Hays , respectively .", + "entities": [ + "vasopressin", + "oxytocin" + ] + }, + { + "id": "10997", + "type": "gene", + "text": "Coronary flow was reduced by 10 % in the phosphocreatine and by 18 % in the control group .", + "entities": [] + }, + { + "id": "10998", + "type": "gene", + "text": "Intraoperative measurement of activated partial thromboplastin time and prothrombin time with a new compact monitor .", + "entities": [ + "thromboplastin", + "prothrombin" + ] + }, + { + "id": "10999", + "type": "gene", + "text": "We suggest that apart from the World Summit for Children ' s under - five mortality target for the year 2000 , intraregional targets to reduce geographical inequalities in under - five mortality should be specified .", + "entities": [] + }, + { + "id": "11000", + "type": "gene", + "text": "Sequence comparison and binding studies of the 18 - bp MOK2 - binding sites present in intron 2 of human , bovine , and mouse IRBP genes show that the 3 ' - half sequence is the essential core element for MOK2 binding .", + "entities": [ + "18 - bp MOK2 - binding sites", + "mouse IRBP genes", + "MOK2" + ] + }, + { + "id": "11001", + "type": "gene", + "text": "Of the 43 infants with a ( probable ) loss 18 were examined again at 3 months corrected age .", + "entities": [] + }, + { + "id": "11002", + "type": "gene", + "text": "The polyubiquitin gene was transcribed throughout the Volvox life cycle with peaks in the 1 . 6 - kb mRNA levels during pre - cleavage , cleavage , and post - inversion .", + "entities": [ + "polyubiquitin gene" + ] + }, + { + "id": "11003", + "type": "gene", + "text": "The ICBF in the ischaemic cortex revealed a graded reduction from the ischaemic centre to the surrounding tissues .", + "entities": [] + }, + { + "id": "11004", + "type": "gene", + "text": "The effect of food on procainamide absorption .", + "entities": [] + }, + { + "id": "11005", + "type": "gene", + "text": "Previous studies have demonstrated that the TATA element is critical for basal and Tat - induced HIV - 1 gene expression .", + "entities": [ + "Tat" + ] + }, + { + "id": "11006", + "type": "gene", + "text": "Role of NH ( 2 ) - and COOH - terminal domains of the P protein of human parainfluenza virus type 3 in transcription and replication .", + "entities": [ + "P protein" + ] + }, + { + "id": "11007", + "type": "gene", + "text": "Pharmacokinetic profile of clonazepam in rhesus monkeys .", + "entities": [] + }, + { + "id": "11008", + "type": "gene", + "text": "She also had slight weakness of the upper extremities .", + "entities": [] + }, + { + "id": "11009", + "type": "gene", + "text": "Furthermore the median increase in cyclosporine DR / C ( SS trough ) was 18 l h - 1 ( - 3 . 1 to 42 . 1 l h - 1 , interquartile range ) .", + "entities": [] + }, + { + "id": "11010", + "type": "gene", + "text": "The structure of the calcineurin A gene was determined by comparison of the genomic and cDNA sequences .", + "entities": [ + "calcineurin A gene" + ] + }, + { + "id": "11011", + "type": "gene", + "text": "The small size and placement of the mutagenesis marker ( the supF suppressor tRNA gene from Escherichia coli ) within the vector substantially reduced the frequency of spontaneous mutations normally observed after transfection of mammalian cells with plasmid DNA ; hence , UV - induced mutations were easily identified above the spontaneous background .", + "entities": [ + "supF suppressor tRNA gene from Escherichia coli" + ] + }, + { + "id": "11012", + "type": "gene", + "text": "Rams were weighed and testis size was estimated by orchimetry at each time period .", + "entities": [] + }, + { + "id": "11013", + "type": "gene", + "text": "Thus , the pol alpha - primase complex appears to act processively for only a short distance .", + "entities": [ + "pol alpha", + "primase" + ] + }, + { + "id": "11014", + "type": "gene", + "text": "Of 254 children with neuroblastoma treated at St .", + "entities": [] + }, + { + "id": "11015", + "type": "gene", + "text": "CONCLUSION : Human preterm birth is associated with significantly lower progesterone / 17 beta - estradiol ratios than those of women with preterm labor delivered at term .", + "entities": [] + }, + { + "id": "11016", + "type": "gene", + "text": "That of the T2 gene contains numerous potential sites for binding the mammalian transcription factor SP1 , but no TATA or CCAAT sequences are evident near to its 5 ' end , although these latter features are associated with the human T1 gene .", + "entities": [ + "T2 gene", + "mammalian transcription factor SP1", + "human T1 gene" + ] + }, + { + "id": "11017", + "type": "gene", + "text": "ATF1 transcription is negatively regulated by unsaturated fatty acids and oxygen .", + "entities": [ + "ATF1" + ] + }, + { + "id": "11018", + "type": "gene", + "text": "Inverse relation between serum IgG concentration and glucose and xylose absorption in Zambian African adults .", + "entities": [ + "IgG" + ] + }, + { + "id": "11019", + "type": "gene", + "text": "In HeLa cells , it activated transcription from the herpes simplex virus type 1 thymidine kinase promoter linked to the chloramphenicol acetyltransferase gene when located in inverted orientation upstream of the thymidine kinase promoter or downstream of the chloramphenicol acetyltransferase gene coding sequence .", + "entities": [ + "herpes simplex virus type 1 thymidine kinase promoter", + "chloramphenicol acetyltransferase gene", + "thymidine kinase promoter", + "chloramphenicol acetyltransferase gene coding sequence" + ] + }, + { + "id": "11020", + "type": "gene", + "text": "Also , component I significantly correlated with fasting insulin and VO2 max for both sexes and with basal metabolism and HDL - cholesterol for females and males , respectively .", + "entities": [ + "insulin", + "HDL - cholesterol" + ] + }, + { + "id": "11021", + "type": "gene", + "text": "Various mutant HN genes were constructed to examine the role of residues flanking the signal - anchor domain , including the cytoplasmic tail , on assembly and intracellular transport of the HN glycoprotein .", + "entities": [ + "mutant HN genes", + "HN glycoprotein" + ] + }, + { + "id": "11022", + "type": "gene", + "text": "In this article , the clinical actions of the principal dopamine receptor stimulating agents ( apomorphine and its derivatives ; piribedil , rye - ergot derivatives ) are discussed on the basis of their biochemical and pharmacological properties .", + "entities": [ + "dopamine receptor" + ] + }, + { + "id": "11023", + "type": "gene", + "text": "To assess the health significance of the early renal changes after chronic exposure to cadmium , 23 workers removed from exposure because of the discovery of an increased urinary excretion of beta 2 - microglobulin or retinol binding protein , or both , have been examined once a year for five years .", + "entities": [ + "beta 2 - microglobulin", + "retinol binding protein" + ] + }, + { + "id": "11024", + "type": "gene", + "text": "Interestingly , disruption of the VPS34 locus resulted in a temperature - sensitive growth defect , indicating that the VPS34 gene is essential for vegetative growth only at elevated growth temperatures .", + "entities": [ + "VPS34 locus", + "VPS34 gene" + ] + }, + { + "id": "11025", + "type": "gene", + "text": "In the predicted transmembrane domain , Casr - rs2 and Casr - rs3 are 95 % identical to Casr - rs1 .", + "entities": [ + "Casr - rs2", + "Casr - rs3", + "Casr - rs1" + ] + }, + { + "id": "11026", + "type": "gene", + "text": "Antipyretic therapy : physiologic rationale , diagnostic implications , and clinical consequences .", + "entities": [] + }, + { + "id": "11027", + "type": "gene", + "text": "To test the role of ML in human reproductive axis , 128 healthy children , 68 boys and 60 girls , were studied .", + "entities": [] + }, + { + "id": "11028", + "type": "gene", + "text": "These alternative splice variants were detected in RNA isolated from several sources , including primary leptomeningeal tissue and an established line of leptomeningeal cells ( LMC ) .", + "entities": [] + }, + { + "id": "11029", + "type": "gene", + "text": "Using a natural dominant negative for AP - 1 transcriptional activity in ROS 17 / 2 . 8 cells , we then showed that AP - 1 transcription factors mediated TGF - beta1 - and BMP - 2 - regulated expression of the ( alpha1 ) collagen I gene as well as TGF - beta1 - regulated expression of the parathyroid hormone ( PTH ) / PTH - related peptide ( PTHrP ) receptor .", + "entities": [ + "AP - 1", + "AP - 1 transcription factors", + "TGF - beta1", + "BMP - 2", + "( alpha1 ) collagen I gene", + "TGF - beta1", + "parathyroid hormone", + "PTH", + "PTH - related peptide ( PTHrP ) receptor" + ] + }, + { + "id": "11030", + "type": "gene", + "text": "Alanine aminotransferase ( ALT ) levels had been elevated for six months in all patients and hepatitis B viral infection was replicative .", + "entities": [ + "Alanine aminotransferase", + "ALT" + ] + }, + { + "id": "11031", + "type": "gene", + "text": "Cestode invasion in irradiated host organism increases the negative effect of ionizing radiation on the hamster immune system .", + "entities": [] + }, + { + "id": "11032", + "type": "gene", + "text": "All of the basal TPN solutions were isonitrogenous and identical in nutrient composition , except for the difference in energy level , which was adjusted with glucose .", + "entities": [] + }, + { + "id": "11033", + "type": "gene", + "text": "Here , we show that aortic explants isolated from PPARalpha - null mice display an exacerbated response to inflammatory stimuli , such as lipopolysaccharide ( LPS ) , as demonstrated by increased IL - 6 secretion .", + "entities": [ + "PPARalpha", + "IL - 6" + ] + }, + { + "id": "11034", + "type": "gene", + "text": "Intrapocket chemotherapy in adult periodontitis using a new controlled - release insert containing ofloxacin ( PT - 01 ) .", + "entities": [] + }, + { + "id": "11035", + "type": "gene", + "text": "Each trial consisted of light and buzzer for five seconds as conditioned stimuli and electric shock for five seconds as an unconditioned stimulus .", + "entities": [] + }, + { + "id": "11036", + "type": "gene", + "text": "Two of the ORFs are completely internal to longer ones and a third is partially embedded in G2850 .", + "entities": [ + "G2850" + ] + }, + { + "id": "11037", + "type": "gene", + "text": "In contrast , the ubiquitous expression of p19 ( INK4d ) has not been previously described in human or murine B - lineage cells .", + "entities": [ + "p19", + "INK4d" + ] + }, + { + "id": "11038", + "type": "gene", + "text": "X2 test , with Yates correction if need , was used as statistical . method .", + "entities": [] + }, + { + "id": "11039", + "type": "gene", + "text": "The clinical picture of the disease was significantly different from anthropogenic cutaneous leishmaniasis caused by L . tropica but similar to cutaneous patterns caused by L . infantum which was a prevalent pattern in the southern France .", + "entities": [] + }, + { + "id": "11040", + "type": "gene", + "text": "Expression plasmids harboring full - length or kinase domain of PKC alpha and PKC delta ( PKC alpha K and PKC delta K ) were constructed .", + "entities": [ + "PKC alpha", + "PKC delta", + "PKC alpha K", + "PKC delta K" + ] + }, + { + "id": "11041", + "type": "gene", + "text": "Cross - talking among Drosophila nuclear receptors at the promiscuous response element of the ng - 1 and ng - 2 intermolt genes .", + "entities": [ + "ng - 1", + "ng - 2 intermolt genes" + ] + }, + { + "id": "11042", + "type": "gene", + "text": "We conclude that ( i ) we have identified several candidate latency genes of murine gammaHV68 , ( ii ) expression of genes during latency may be different in different organs , consistent with multiple latency programs and / or multiple cellular sites of latency , and ( iii ) regions of the viral genome ( v - bcl - 2 gene , v - GCR gene , and gene 73 ) are transcribed during latency with both gammaHV68 and primate gammaherpesviruses .", + "entities": [ + "v - bcl - 2 gene", + "v - GCR gene", + "gene 73" + ] + }, + { + "id": "11043", + "type": "gene", + "text": "The drug - resistant cell lines P388 / ADR / 3 and P388 / ADR / 7 express a shortened topo II alpha mRNA transcript in addition to the native transcript present in the drug - sensitive P388 / 4 cell line .", + "entities": [ + "topo II alpha mRNA transcript" + ] + }, + { + "id": "11044", + "type": "gene", + "text": "V .", + "entities": [] + }, + { + "id": "11045", + "type": "gene", + "text": "When the blood clot is formed in the vitreous cavity , intravitreal injection of t - PA can convert plasminogen to plasmin and remove the clot .", + "entities": [ + "t - PA", + "plasminogen", + "plasmin" + ] + }, + { + "id": "11046", + "type": "gene", + "text": "The CAPLC1 protein also exhibited several unique features , including a novel stretch of 18 - 19 amino acid residues within the X domain and an unusually long N - terminus which did not contain a recognizable EF - hand Ca ( 2 + ) - binding domain .", + "entities": [ + "CAPLC1 protein" + ] + }, + { + "id": "11047", + "type": "gene", + "text": "Diagnostic value of serum myoglobin in cases of neuromuscular disease", + "entities": [ + "serum myoglobin" + ] + }, + { + "id": "11048", + "type": "gene", + "text": "The Mif1 5 ' flanking region contains a functional ER stress - responsive element which is sufficient for induction by tunicamycin .", + "entities": [ + "Mif1 5 ' flanking region" + ] + }, + { + "id": "11049", + "type": "gene", + "text": "Thus , the association of PS1 fragments may be maintained during cycles of phosphorylation / dephosphorylation of the PS1 CTF .", + "entities": [ + "PS1 fragments", + "PS1 CTF" + ] + }, + { + "id": "11050", + "type": "gene", + "text": "Northern blotting with a unique 17 - mer oligonucleotide demonstrated the absence of the mutant sequence in the mRNA from which the cDNA library giving rise to the mutant cDNA was constructed .", + "entities": [] + }, + { + "id": "11051", + "type": "gene", + "text": "E2 treatments elevated hen plasma TG 7 . 2X , PL 5 . 1X , and C 7 . 2X ; and pullet plasma TG 6 . 8X , PL 3 . 7X , and C 2 . 5X .", + "entities": [] + }, + { + "id": "11052", + "type": "gene", + "text": "Here we describe a mutant alpha subunit designed to inhibit receptor - mediated hormonal activation of Gs , the stimulatory regulator of adenylyl cyclase .", + "entities": [ + "Gs", + "adenylyl cyclase" + ] + }, + { + "id": "11053", + "type": "gene", + "text": "These results lead us to hypothesize that a single multisubunit TFIID protein supports transcriptional stimulation by diverse activation domains and from a TATA - less promoter .", + "entities": [ + "multisubunit TFIID protein" + ] + }, + { + "id": "11054", + "type": "gene", + "text": "We have identified two overlapping expressed sequence tag clones , which contain the missing 4 . 4 - kb 3 ' - UTR of the human D2 ( hD2 ) cDNA .", + "entities": [ + "human D2", + "hD2" + ] + }, + { + "id": "11055", + "type": "gene", + "text": "A human nuclear - localized chaperone that regulates dimerization , DNA binding , and transcriptional activity of bZIP proteins .", + "entities": [ + "bZIP proteins" + ] + }, + { + "id": "11056", + "type": "gene", + "text": "Glucose - 6 - phosphate dehydrogenase ( G - 6 - PD ) deficiency in the newborn .", + "entities": [ + "Glucose - 6 - phosphate dehydrogenase", + "G - 6 - PD" + ] + }, + { + "id": "11057", + "type": "gene", + "text": "A cAMP response element ( CRE ) consensus signal was identified in the 5 ' - noncoding region .", + "entities": [] + }, + { + "id": "11058", + "type": "gene", + "text": "cAMP regulates the expression of Kv1 . 5 gene in a cell - specific manner .", + "entities": [ + "Kv1 . 5 gene" + ] + }, + { + "id": "11059", + "type": "gene", + "text": "The carboxyl - terminal proline - rich domain of SOS1 is involved in the interaction with the PLC - gamma1 SH3 domain .", + "entities": [ + "SOS1", + "SH3 domain" + ] + }, + { + "id": "11060", + "type": "gene", + "text": "Scmh1 maps to 4D1 - D2 . 1 in mice .", + "entities": [ + "Scmh1" + ] + }, + { + "id": "11061", + "type": "gene", + "text": "In metabolic acidosis there was a marked stimulation when clamped at - 10 to - 100 mV .", + "entities": [] + }, + { + "id": "11062", + "type": "gene", + "text": "Likewise , rad6 - delta reduces silencing of the telomere - located RNAP II - transcribed genes URA3 and ADE2 .", + "entities": [ + "rad6 - delta", + "telomere - located RNAP II - transcribed genes URA3", + "ADE2" + ] + }, + { + "id": "11063", + "type": "gene", + "text": "Interestingly , the RNA sequences selected by the mutated zinc knuckle 9G8 variant are efficiently recognized by SRp20 , in agreement with the fact that the RBD of 9G8 and SRp20 are similar .", + "entities": [ + "zinc knuckle 9G8 variant", + "SRp20", + "9G8", + "SRp20" + ] + }, + { + "id": "11064", + "type": "gene", + "text": "A critical heart rate and / or appropriate sympathetic state was found to provoke all instances of reentrant or automatic atrial tachycardia and atypical junctional tachycardia .", + "entities": [] + }, + { + "id": "11065", + "type": "gene", + "text": "A computed tomographic scan obtained after EOE - 13 infusion accurately showed the perfusion pattern of the implanted catheter .", + "entities": [] + }, + { + "id": "11066", + "type": "gene", + "text": "The highest prevalence of reported pet allergy , chronic cough , wheeze , attacks of shortness of breath with wheezing , and doctor - diagnosed asthma was found in children who had pets in the past but not anymore .", + "entities": [] + }, + { + "id": "11067", + "type": "gene", + "text": "The reproductive effects of the administration of 4 - chloro - 2 - methylphenoxyacetic acid ( MCPA ) to rats were evaluated through two generations , from prior to mating , throughout mating , to gestation and lactation .", + "entities": [] + }, + { + "id": "11068", + "type": "gene", + "text": "In particular , Western , supershift , and promoter deletion analyses suggested a role for CCAAT / enhancer - binding protein - beta ( C / EBP - beta ) binding site between - 2010 and - 1954 in regulating transcription of collagenase - 1 in monocytic cells .", + "entities": [ + "CCAAT / enhancer - binding protein - beta", + "C / EBP - beta", + "collagenase - 1" + ] + }, + { + "id": "11069", + "type": "gene", + "text": "A cDNA for a newly discovered pseudogene , closely related to the mouse mast cell chymases was isolated by polymerase chain reaction amplification from a mouse connective tissue - like mast cell line .", + "entities": [ + "mouse mast cell chymases" + ] + }, + { + "id": "11070", + "type": "gene", + "text": "In PC , rare MNGCs had intranuclear inclusions and grooves .", + "entities": [] + }, + { + "id": "11071", + "type": "gene", + "text": "The patients who presented with mucocutaneous disease also had low CD4 + T lymphocyte counts , and most of them had AIDS defining illnesses .", + "entities": [ + "CD4 +" + ] + }, + { + "id": "11072", + "type": "gene", + "text": "Cloning and characterization of a cDNA encoding a bacteriophage - type RNA polymerase from the higher plant Chenopodium album .", + "entities": [ + "bacteriophage - type RNA polymerase" + ] + }, + { + "id": "11073", + "type": "gene", + "text": "Pacing the Roux limb abolished the ectopic pacemakers , restored the slow emptying of liquids to the more rapid rate found in the Billroth dogs ( t1 / 2 : paced Roux , 72 + / - 15 minutes ; Billroth , 43 + / - 9 minutes ; p greater than 0 . 05 ) and did not change emptying of solids .", + "entities": [] + }, + { + "id": "11074", + "type": "gene", + "text": "Taken together , these findings show that 16K hPRL inhibits the VEGF - induced Ras activation ; this antagonism represents a novel and potentially important mechanism for the control of angiogenesis .", + "entities": [ + "16K hPRL", + "VEGF", + "Ras" + ] + }, + { + "id": "11075", + "type": "gene", + "text": "In this model , eltoprazine has a very specific anti - aggressive ( serenic ) profile , inhibiting aggression while social interaction and exploration are not decreased but even enhanced ; inactivity , a measure for sedation , is not affected .", + "entities": [] + }, + { + "id": "11076", + "type": "gene", + "text": "The interrelation of the levels of glucocorticoids and insulin in the blood of irradiated animals", + "entities": [ + "insulin" + ] + }, + { + "id": "11077", + "type": "gene", + "text": "Intracavitary irradiation was carried out with a microSelectron HDR afterloading device and usually 22 . 5 Gy was given in three fractions repeated weekly .", + "entities": [] + }, + { + "id": "11078", + "type": "gene", + "text": "A significant correlation between a number of functional parameters of gastric secretion , incretion and histological changes of gastric mucosa was found in patients with chronic gastritis .", + "entities": [] + }, + { + "id": "11079", + "type": "gene", + "text": "The harpin - encoding hrpZ gene is located in an operon that also encodes Hrp secretion pathway components and is part of the functional cluster of hrp genes carried on cosmid pHIR11 that enables saprophytic bacteria like Escherichia coli and Pseudomonas fluorescens to elicit the HR in tobacco leaves .", + "entities": [ + "harpin", + "hrpZ gene", + "Hrp secretion pathway components", + "hrp genes" + ] + }, + { + "id": "11080", + "type": "gene", + "text": "The method requires a reversed - phase column and a paired - ion technique to separate docusate sodium from other components .", + "entities": [] + }, + { + "id": "11081", + "type": "gene", + "text": "In several cases of definite SjS , labial salivary gland examinations after more than a one year interval were performed on two occasions , and the clinical and histopathological changes were investigated .", + "entities": [] + }, + { + "id": "11082", + "type": "gene", + "text": "Previous experimental evidence had indicated that Reg1 might target Glc7 to nuclear substrates such as the Snf1 kinase complex .", + "entities": [ + "Reg1", + "Glc7", + "Snf1 kinase complex" + ] + }, + { + "id": "11083", + "type": "gene", + "text": "These factors belong to a set of genetically distinct molecules , including AP - 4 and MLTF , that bind to the CACCTGTC motif or related sequences .", + "entities": [ + "AP - 4", + "MLTF" + ] + }, + { + "id": "11084", + "type": "gene", + "text": "SF - 1 does not have an N - terminal AF1 domain .", + "entities": [ + "SF - 1" + ] + }, + { + "id": "11085", + "type": "gene", + "text": "Allergy and Tourette ' s syndrome .", + "entities": [] + }, + { + "id": "11086", + "type": "gene", + "text": "Together , these results suggest that EGF / Ras / Raf induces transcription via combined activation of ATF3 / c - Jun and a 52 - kDa nuclear factor , whereas JunD acts as a repressor of this response .", + "entities": [ + "EGF", + "Ras", + "Raf", + "ATF3", + "c - Jun", + "JunD" + ] + }, + { + "id": "11087", + "type": "gene", + "text": "The histological grading was certified in 68 cases : 12 G1 , 39 G2 , 17 G3 ; extracapsular spread was found in 20 / 54 cases ( 37 % ) .", + "entities": [] + }, + { + "id": "11088", + "type": "gene", + "text": "These data indicate a functional role for U1 in NRS - mediated splicing inhibition .", + "entities": [ + "U1", + "NRS" + ] + }, + { + "id": "11089", + "type": "gene", + "text": "There was a slight increase in total transferrin 2 hr after 1 tablet and values remained high throughout the experiment .", + "entities": [ + "transferrin" + ] + }, + { + "id": "11090", + "type": "gene", + "text": "Two techniques based on assay coefficients of variation were employed to characterize a normal circadian pattern of cortisol .", + "entities": [] + }, + { + "id": "11091", + "type": "gene", + "text": "The inhibition of focus formation observed in the presence of C3G was not due to toxic effects on cell viability , since transfected C3G cells exhibited the same survival and growth rates as untransfected NIH3T3 cells or cells transfected with plasmid vector alone .", + "entities": [ + "C3G", + "C3G" + ] + }, + { + "id": "11092", + "type": "gene", + "text": "Nitrofurazone significantly reduced the rise in LH induced by LHRH .", + "entities": [ + "LH", + "LHRH" + ] + }, + { + "id": "11093", + "type": "gene", + "text": "Freezing of plasma to obtain better yield of factor VIII : C .", + "entities": [ + "factor VIII" + ] + }, + { + "id": "11094", + "type": "gene", + "text": "Mutation of the C / EBP binding sites in the Rous sarcoma virus long terminal repeat and gag enhancers .", + "entities": [ + "C / EBP binding sites", + "Rous sarcoma virus long terminal repeat", + "gag enhancers" + ] + }, + { + "id": "11095", + "type": "gene", + "text": "In a second experiment involving an 18 - h lung clearance assay , we used the mAb 3 . 2 . 3 to deplete rats of LGL / NK cells with the following rationale : if LGL / NK cells are necessary to mediate an event , then in their absence , that event should not occur .", + "entities": [ + "mAb 3 . 2 . 3" + ] + }, + { + "id": "11096", + "type": "gene", + "text": "We used two approaches to ascertain whether CDP / cut serves as a repressor of gp91 - phox gene expression .", + "entities": [ + "CDP", + "cut", + "gp91", + "phox" + ] + }, + { + "id": "11097", + "type": "gene", + "text": "The STAT protein accumulation resulting from C / EBP expression was tightly coupled to the morphological conversion of fibroblasts to adipocytes and represents an expression profile identical to that reported for mature adipocytes in vivo .", + "entities": [ + "STAT protein", + "C / EBP" + ] + }, + { + "id": "11098", + "type": "gene", + "text": "Two domains of EBNA2 defined by deletion of amino acids 247 - 337 and 437 - 476 were found to be important for the activation of both promoters , while two different domains corresponding to residues 4 - 18 and 118 - 198 were required solely for the LMP1 promoter .", + "entities": [ + "EBNA2", + "LMP1 promoter" + ] + }, + { + "id": "11099", + "type": "gene", + "text": "This activity is stimulated by complex formation with the other eIF2B subunits .", + "entities": [ + "eIF2B subunits" + ] + }, + { + "id": "11100", + "type": "gene", + "text": "The purpose of this investigation was to study the morphological characteristics of the fibrous tissue capsule resulting from the implantation of aluminum calcium phosphate ( ALCAP ) and hydroxyapetite ( HA ) bioceramics .", + "entities": [] + }, + { + "id": "11101", + "type": "gene", + "text": "These introns contain only single snoRNA genes and their processing involves exonucleolytic release of the snoRNA from debranched intron lariats .", + "entities": [ + "snoRNA genes" + ] + }, + { + "id": "11102", + "type": "gene", + "text": "Angina ( Q ) persistence showed marked associations with previous myocardial infarction , diagnosed angina , electrocardiogram ischemia , and subsequent major ischemic heart disease events from Q5 onward .", + "entities": [] + }, + { + "id": "11103", + "type": "gene", + "text": "The yeast enzyme was 6 - fold slower than the mammalian enzymes , which made it amenable to pre - steady - state stopped - flow spectroscopic kinetic analysis at 30 degrees C and pH 6 . 0 .", + "entities": [] + }, + { + "id": "11104", + "type": "gene", + "text": "Phosphorylation of tyrosine residues in the kinase domain and juxtamembrane region regulates the biological and catalytic activities of Eph receptors .", + "entities": [ + "Eph receptors" + ] + }, + { + "id": "11105", + "type": "gene", + "text": "Canine reproduction : effects of a single injection of medroxyprogesterone acetate on the reproductive organs of the bitch .", + "entities": [] + }, + { + "id": "11106", + "type": "gene", + "text": "A case of anterior cleavage syndrome in a 27 - year - old female patient is described .", + "entities": [] + }, + { + "id": "11107", + "type": "gene", + "text": "However , rapamycin inhibited proliferation of Ba / F3 - EpoRgp55 but not of MEL cells despite inhibition of p70 S6 kinase activity in both cells .", + "entities": [ + "p70 S6 kinase" + ] + }, + { + "id": "11108", + "type": "gene", + "text": "By contrast , secretory HI antibodies were not demonstrated at the onset of illness in any of the patients , but their formation started early and the antibodies reached maximal levels about 10 days after onset of illness .", + "entities": [ + "secretory HI antibodies" + ] + }, + { + "id": "11109", + "type": "gene", + "text": "Overexpression of either DAP - 1 or sentrin causes apoptosis of TNF - sensitive L929 fibroblast cell line , as well as TNF - resistant osteosarcoma cell line , U2OS .", + "entities": [ + "DAP - 1", + "sentrin", + "TNF", + "TNF" + ] + }, + { + "id": "11110", + "type": "gene", + "text": "Like the Tob protein , Tob2 inhibited cell cycle progression from the G0 / G1 to S phases .", + "entities": [ + "Tob protein", + "Tob2" + ] + }, + { + "id": "11111", + "type": "gene", + "text": "The N - syndecan - dependent neurite outgrowth is inhibited by the tyrosine kinase inhibitors herbimycin A and PP1 .", + "entities": [ + "tyrosine kinase", + "PP1" + ] + }, + { + "id": "11112", + "type": "gene", + "text": "Administration of the dopamine agonist bromocriptine ( 2 . 5 mg three times a day for 4 days ) suppressed ( P less than 0 . 01 ) mean 24 - h plasma 18 - OHB levels from 21 . 9 + / - 2 . 0 to 14 . 8 + / - 1 . 4 ng / dl .", + "entities": [] + }, + { + "id": "11113", + "type": "gene", + "text": "Two Pax2 / 5 / 8 - binding sites in Engrailed2 are required for proper initiation of endogenous mid - hindbrain expression .", + "entities": [ + "Pax2 / 5 / 8 - binding sites", + "Engrailed2" + ] + }, + { + "id": "11114", + "type": "gene", + "text": "The use of specific antibodies allowed the identification of at least RAR beta in some of the DNA - protein complexes , although the four sequences bind single RARs transfected in COS cells much less efficiently , or not at all , when compared to a canonical RAR responsive element .", + "entities": [ + "RAR beta", + "RARs", + "RAR responsive element" + ] + }, + { + "id": "11115", + "type": "gene", + "text": "They consisted of behavioural disorders , tetraparesis , incontinence and oculomotor paralysis .", + "entities": [] + }, + { + "id": "11116", + "type": "gene", + "text": "The gene ( ApxII ) encoding both chloroplastic ascorbate peroxidase isoenzymes was isolated and the organization of the gene was determined .", + "entities": [ + "ApxII", + "chloroplastic ascorbate peroxidase isoenzymes" + ] + }, + { + "id": "11117", + "type": "gene", + "text": "Genes belonging to the ras superfamily encode low - molecular - weight GTP / GDP - binding proteins that are highly conserved in wide variety of organisms .", + "entities": [ + "ras superfamily", + "low - molecular - weight GTP / GDP - binding proteins" + ] + }, + { + "id": "11118", + "type": "gene", + "text": "Comparison of cDNA and genomic sequences shows that the ZNF189 gene spans approximately 11 kb and is organized into at least four exons , the large 3 ' - end exon coding for the complete zinc finger domain and the 3 ' untranslated region .", + "entities": [ + "ZNF189 gene" + ] + }, + { + "id": "11119", + "type": "gene", + "text": "Her serum FT3 concentration was , however , much higher than the ranges in normal pregnancy or in GTD patients without clinical hyperthyroidism .", + "entities": [] + }, + { + "id": "11120", + "type": "gene", + "text": "In two further cases ( one type I and one type III SMA ) , de novo deletions of only one copy of Ag1 - CA and C212 were found .", + "entities": [ + "Ag1 - CA", + "C212" + ] + }, + { + "id": "11121", + "type": "gene", + "text": "Additional factors such as advanced age , concomitant use of corticosteroids or anticoagulants , prior ulcer complications and co - morbid diseases may further increase the risk of bleeding .", + "entities": [] + }, + { + "id": "11122", + "type": "gene", + "text": "Collagen was extracted from the skin , and the lack of type III collagen was determined by means of sodium dodecyl sulfate - polyacrylamide gel electrophoresis ( SDS - PAGE ) .", + "entities": [ + "Collagen", + "type III collagen" + ] + }, + { + "id": "11123", + "type": "gene", + "text": "Scanning electron microscopic investigations on the formation of Reissner ' s fiber in Rattus rattus", + "entities": [] + }, + { + "id": "11124", + "type": "gene", + "text": "The human eps15 gene , encoding a tyrosine kinase substrate , is conserved in evolution and maps to 1p31 - p32 .", + "entities": [ + "human eps15 gene", + "tyrosine kinase" + ] + }, + { + "id": "11125", + "type": "gene", + "text": "We show that the Sm - binding site and stem - loop III structures are necessary for correct 3 ' - end formation .", + "entities": [ + "Sm - binding site" + ] + }, + { + "id": "11126", + "type": "gene", + "text": "Electron microscopic and enzymatic analyses revealed that the A118 genome is a linear , circularly permuted , terminally redundant collection of double - stranded DNA molecules .", + "entities": [] + }, + { + "id": "11127", + "type": "gene", + "text": "Down - regulation of IRS - 1 is linked to its serine phosphorylation dependent on PI 3 - kinase activity and appears required for differentiation to occur , as IRS - 1 is not modified and continues to accumulate in a nondifferentiating myoblast cell line .", + "entities": [ + "IRS - 1", + "PI 3 - kinase", + "IRS - 1" + ] + }, + { + "id": "11128", + "type": "gene", + "text": "In contrast to other known retroviruses , the FV pol genes are expressed via spliced transcripts .", + "entities": [ + "FV pol genes" + ] + }, + { + "id": "11129", + "type": "gene", + "text": "The difference between the patients and the controls was statistically significant ( p = 0 . 03 ) .", + "entities": [] + }, + { + "id": "11130", + "type": "gene", + "text": "Gel mobility shift assays indicated that at least four nuclear proteins with distinct biochemical and binding properties possess the ability to bind the 3 beta I - A element to produce four DNA - protein complexes ( R1 to R4 ) .", + "entities": [] + }, + { + "id": "11131", + "type": "gene", + "text": "However , activation of the cAMP pathway , which is known to regulate inhibin alpha expression , greatly enhanced the actions of SF - 1 .", + "entities": [ + "inhibin alpha", + "SF - 1" + ] + }, + { + "id": "11132", + "type": "gene", + "text": "Both classes of MHBst proteins were found to form dimers ; an which is involved in mediating the dimerization .", + "entities": [ + "MHBst proteins" + ] + }, + { + "id": "11133", + "type": "gene", + "text": "Anti - PTB antibodies did not inhibit the binding of PTB to RNA because they were able to supershift RNA - PTB complexes .", + "entities": [ + "Anti - PTB antibodies", + "PTB", + "RNA - PTB complexes" + ] + }, + { + "id": "11134", + "type": "gene", + "text": "Endo16 transcripts are confined to the definitive vegetal plate in blastula stage embryos ; at gastrula stage this gene is expressed throughout the archenteron , but later only in the midgut .", + "entities": [ + "Endo16 transcripts" + ] + }, + { + "id": "11135", + "type": "gene", + "text": "The third domain had the motif of a cAMP response element ( CRE ) .", + "entities": [] + }, + { + "id": "11136", + "type": "gene", + "text": "Overexpression of c - Myc in serum - starved human or mouse embryonic cells leads to apoptosis which is significantly reduced in the presence of growth factor - containing serum .", + "entities": [ + "c - Myc" + ] + }, + { + "id": "11137", + "type": "gene", + "text": "c - Myc - induced apoptosis appears to be deficient in bax - null as compared with bax - wild - type mouse embryonic fibroblasts .", + "entities": [ + "c - Myc", + "bax", + "bax" + ] + }, + { + "id": "11138", + "type": "gene", + "text": "A coiled - coil domain , conserved within each encoded protein , serves as a potential interaction motif for FLI LRR .", + "entities": [ + "FLI LRR" + ] + }, + { + "id": "11139", + "type": "gene", + "text": "Mibefradil ( Ro 40 - 5967 ) is a novel calcium antagonist from a new chemical class and is the first that selectively blocks the T - type calcium channel .", + "entities": [] + }, + { + "id": "11140", + "type": "gene", + "text": "In controls , most of the output from the conduit occurred during type I activity ( 73 + / - 14 % ) .", + "entities": [] + }, + { + "id": "11141", + "type": "gene", + "text": "On T2 weighted images , low intensity areas in the thalamus , the striatum , the anterior limb of the internal capsule , the tegmentum of midbrain , high intensity areas in middle cerebellar peduncle , the posterior limb of the internal capsule , the lateral part of the cerebral peduncle , and the cerebral white matter were noted .", + "entities": [] + }, + { + "id": "11142", + "type": "gene", + "text": "In addition to homologues of the human genes PSMB5 through PSMB9 , two new genes , PSMB11 and PSMB12 , have been found for which there are no known corresponding genes in humans .", + "entities": [ + "human genes PSMB5", + "PSMB9", + "PSMB11", + "PSMB12" + ] + }, + { + "id": "11143", + "type": "gene", + "text": "The obtained results were compared with control group ( 10 female volunteers ) .", + "entities": [] + }, + { + "id": "11144", + "type": "gene", + "text": "Endogenous release of neuronal serotonin and 5 - hydroxyindoleacetic acid in the caudate - putamen of the rat as revealed by intracerebral dialysis coupled to high - performance liquid chromatography with fluorimetric detection .", + "entities": [] + }, + { + "id": "11145", + "type": "gene", + "text": "Chlamydial agents were isolated from the semen near the end of the chlamydemic phase .", + "entities": [] + }, + { + "id": "11146", + "type": "gene", + "text": "The transactivation function of EBNA2 was also observed in the HeLa epithelial cell line , which suggests that EBV and HIV - 1 infection of non - B cells may result in HIV - 1 promoter activation .", + "entities": [ + "EBNA2", + "HIV - 1 promoter" + ] + }, + { + "id": "11147", + "type": "gene", + "text": "Oligonucleotide probes corresponding to wild - type and mutant EpRE sequences were used in gel - shift and super - shift analyses to identify proteins binding .", + "entities": [] + }, + { + "id": "11148", + "type": "gene", + "text": "Sequence analysis revealed : 1 ) a kinase catalytic domain most characteristic of serine / threonine kinases but hybrid between members of the family of microtubule - associated protein kinase kinase kinases and the fibroblast growth factor receptor family ; 2 ) two putative alpha - helical leucine zipper motifs separated by a 25 - amino acid charged intermediate segment but lacking an NH2 - terminal basic domain ; and 3 ) COOH - terminal and NH2 - terminal proline - rich domains suggestive of src homology 3 ( SH3 ) domain binding regions .", + "entities": [ + "serine / threonine kinases", + "microtubule - associated protein kinase kinase kinases", + "fibroblast growth factor receptor family", + "src homology 3", + "SH3" + ] + }, + { + "id": "11149", + "type": "gene", + "text": "OBJECTIVE : The study was designed to investigate the frequency of alterations in serum creatinine in patients with psoriasis receiving 5 mg / kg / day of cyclosporine .", + "entities": [] + }, + { + "id": "11150", + "type": "gene", + "text": "T7 transcription could be manipulated to achieve different levels of constitutive expression , through the use of promoter mutations .", + "entities": [] + }, + { + "id": "11151", + "type": "gene", + "text": "More specific adverse events , also frequently considered as dose - limiting toxicities , include hypotension with IL - 1 , severe headache or skin rash with IL - 3 , and nasal congestion and gastroduodenal lesions with IL - 4 .", + "entities": [ + "IL - 1", + "IL - 3", + "IL - 4" + ] + }, + { + "id": "11152", + "type": "gene", + "text": "EEG theta waves and psychological phenomena : a review and analysis .", + "entities": [] + }, + { + "id": "11153", + "type": "gene", + "text": "Other than d 7 , there was no significant effect on the number of implants .", + "entities": [] + }, + { + "id": "11154", + "type": "gene", + "text": "The naltrexone / lofexidine combination was associated with a more rapid resolution of the opiate withdrawal syndrome than a 7 - day lofexidine - only treatment schedule , without substantial increases in withdrawal symptoms or hypotensive side - effects .", + "entities": [] + }, + { + "id": "11155", + "type": "gene", + "text": "Although pathological thyroid function is related to changes in energy expenditure and body composition , its possible influence on leptin levels remains to be determined .", + "entities": [ + "leptin" + ] + }, + { + "id": "11156", + "type": "gene", + "text": "A full - length human pim - 1 cDNA was subcloned into the bacterial vector pGEX - 2T and the Pim - 1 protein expressed as a fusion product with bacterial glutathione S - transferase ( GST ) .", + "entities": [ + "full - length human pim - 1 cDNA", + "Pim - 1 protein", + "bacterial glutathione S - transferase", + "GST" + ] + }, + { + "id": "11157", + "type": "gene", + "text": "The presence of the foreign gene was confirmed by Southern analysis .", + "entities": [] + }, + { + "id": "11158", + "type": "gene", + "text": "Recently , it was shown that purified RAG1 / 2 proteins can cleave DNA hairpins in vitro , but the same activity was also described for a protein complex of the DNA repair proteins Nbs1 / Mre11 / Rad50 .", + "entities": [ + "RAG1 / 2 proteins", + "Nbs1", + "Mre11", + "Rad50" + ] + }, + { + "id": "11159", + "type": "gene", + "text": "The ParaSight - F test alone was used to monitor serum antigen levels after treatment in 24 patients .", + "entities": [] + }, + { + "id": "11160", + "type": "gene", + "text": "TMBr - 1 is identical to striated muscle alpha - tropomyosin from amino acids 1 through 258 but contains a novel COOH - terminal region from amino acids 259 through 281 .", + "entities": [ + "TMBr - 1", + "striated muscle alpha - tropomyosin" + ] + }, + { + "id": "11161", + "type": "gene", + "text": "Statistical Analysis included ANOVA , the Pearson Product Moment Correlation Coefficient , Principal Components Analysis and Discriminant Function Analysis and the calculation of Cronbach ' s alpha ( alpha ) RESULTS : Both Sensitivity and specificity exceed 90 . 00 at 23 / 24 , Chronbach ' s alpha for the total scale was equal to 0 . 95 .", + "entities": [] + }, + { + "id": "11162", + "type": "gene", + "text": "DNA strand exchange catalyzed by Rad51 protein is also greatly stimulated by RPA .", + "entities": [ + "Rad51 protein", + "RPA" + ] + }, + { + "id": "11163", + "type": "gene", + "text": "We conclude that at steady state the timing of a light meal is unlikely to alter in any clinically important manner the pharmacokinetics of nifedipine released from ' biphasic ' tablets .", + "entities": [] + }, + { + "id": "11164", + "type": "gene", + "text": "Interferon beta therapy was discontinued for 4 weeks .", + "entities": [ + "Interferon beta" + ] + }, + { + "id": "11165", + "type": "gene", + "text": "Promoter activities were estimated using beta - glucuronidase and neomycin phosphotransferase II reporter gene systems .", + "entities": [ + "beta - glucuronidase", + "neomycin phosphotransferase II reporter gene systems" + ] + }, + { + "id": "11166", + "type": "gene", + "text": "Our findings demonstrate a dose - dependent blockade of the mechanical sensitivity caused by a mild thermal injury by both GBP and IBG .", + "entities": [] + }, + { + "id": "11167", + "type": "gene", + "text": "Altogether our data indicate that PEDF belongs to the subgroup of noninhibitory serpins and that its N - terminal region confers a neurite - promoting activity to the protein .", + "entities": [ + "PEDF", + "serpins" + ] + }, + { + "id": "11168", + "type": "gene", + "text": "We have isolated and functionally characterized the mouse gene for the C2 subunit of the 20S proteasome .", + "entities": [ + "20S proteasome" + ] + }, + { + "id": "11169", + "type": "gene", + "text": "By electrophoresis mobility shift assays using probes corresponding to different segments of the putative human c - myb intron 1 transcription pause region and nuclear extracts from myeloid leukemia HL 60 and fibroblast WI 38 cells , we detected a HL - 60 - specific DNA - protein complex with a 123 - bp fragment containing binding sites for the interferon regulatory factors ( IRFs ) nuclear proteins .", + "entities": [ + "human c - myb intron 1 transcription pause region", + "interferon regulatory factors", + "IRFs" + ] + }, + { + "id": "11170", + "type": "gene", + "text": "Absorption was rapid , with a mean time to peak of 39 min .", + "entities": [] + }, + { + "id": "11171", + "type": "gene", + "text": "Two BASIC computer programs using logit transformation for the analysis of S - shaped curves are presented .", + "entities": [] + }, + { + "id": "11172", + "type": "gene", + "text": "However , butyrate was at least 2 - fold more effective in stimulating CAT activity of fusion genes containing upstream sequences ( - 834 to - 576 ) than those containing proximal sequences ( - 456 to - 172 ) , suggesting two regions in the PSG1 - I gene that mediate the butyrate response .", + "entities": [ + "CAT", + "PSG1 - I gene" + ] + }, + { + "id": "11173", + "type": "gene", + "text": "The alpha 2A - adrenergic receptor ( alpha 2AAR ) is coupled to a variety of effectors via pertussis toxin - sensitive GTP - binding proteins .", + "entities": [ + "alpha 2A - adrenergic receptor", + "alpha 2AAR", + "pertussis toxin", + "GTP - binding proteins" + ] + }, + { + "id": "11174", + "type": "gene", + "text": "Members of the titin / myosin light chain kinase family play an essential role in the organization of the actin / myosin cytoskeleton , especially in sarcomere assembly and function .", + "entities": [ + "titin", + "myosin light chain kinase", + "actin", + "myosin" + ] + }, + { + "id": "11175", + "type": "gene", + "text": "The cytosolic glutathione S - transferases ( GSTs , EC 2 . 5 . 1 . 18 ) are a superfamily of dimeric isoenzymes which catalyze the conjugation of electrophilic substrates with glutathione .", + "entities": [ + "glutathione S - transferases", + "GSTs", + "EC 2 . 5 . 1 . 18" + ] + }, + { + "id": "11176", + "type": "gene", + "text": "Human Duo contains a guanine nucleotide exchange factor ( GEF ) domain that is likely to be rac1 - specific , a pleckstrin homology ( PH ) domain and spectrin - like repeat units .", + "entities": [ + "Human Duo", + "guanine nucleotide exchange factor", + "GEF", + "rac1", + "pleckstrin homology", + "PH", + "spectrin - like repeat units" + ] + }, + { + "id": "11177", + "type": "gene", + "text": "Conjugated and unconjugated phenylacetic acid and m - and p - hydroxyphenylacetic acid have been determined in the plasma of normal , healthy subjects after fasting , consumption of a meal and ingestion of deuterium labelled amine precursors , by high - resolution gas chromatography - - high resolution mass spectrometry with selected ion monitoring of their trifluoroethyl - pentafluoropropionyl derivatives .", + "entities": [] + }, + { + "id": "11178", + "type": "gene", + "text": "Experimental studies on virus excretion and non - arthropod transmission .", + "entities": [] + }, + { + "id": "11179", + "type": "gene", + "text": "IFN - gamma was elevated during active TB when compared with healthy controls , declining during and after treatment .", + "entities": [ + "IFN - gamma" + ] + }, + { + "id": "11180", + "type": "gene", + "text": "We compared the parameters pleural adenosine deaminase ( PADA , determined in 405 patients ) , the PADA / serum ADA ratio ( P / SADA ; 276 cases ) , pleural lysozyme ( PLYS , 276 cases ) , the PLYS / serum LYS ratio ( P / SLYS ; 276 cases ) , and pleural interferon gamma ( IFN , 145 cases ) regarding their ability to differentiate tuberculous pleural effusions from others .", + "entities": [ + "pleural adenosine deaminase", + "PADA", + "PADA", + "serum ADA", + "P", + "SADA", + "pleural lysozyme", + "PLYS", + "PLYS", + "serum LYS", + "P", + "SLYS", + "pleural interferon gamma", + "IFN" + ] + }, + { + "id": "11181", + "type": "gene", + "text": "LD50 values of terms of KP were 84 mg / kg in male rats and 122 mg / kg in female rats when KP - CMC was administered intrarectally , and 117 mg / kg in male and 92 mg / kg in female when KP - T10 was administered intrarectally . , while peroral administration of KP - CMC showed LD50 values of 68 mg / kg in males and 78 mg / kg in females in terms of KP .", + "entities": [] + }, + { + "id": "11182", + "type": "gene", + "text": "GABA ( B ) R1g was expressed in both brain and peripheral tissues .", + "entities": [ + "GABA ( B ) R1g" + ] + }, + { + "id": "11183", + "type": "gene", + "text": "We now show that RNU2 fragility can be induced by transfection with an expression vector encoding Ad12 E1B 55 kDa alone but not by an E1 vector encoding all E1 products ( 3 E1A proteins , as well as the E1B 19 kDa and 55 kDa proteins ) .", + "entities": [ + "RNU2", + "Ad12 E1B", + "E1", + "E1 products", + "E1A proteins", + "E1B" + ] + }, + { + "id": "11184", + "type": "gene", + "text": "Although the consumption of myoglobin - bound O2 ( MbO2 ) stores in seal muscles has been demonstrated in seal muscles during laboratory simulations of diving , this may not be a feature of normal field diving in which measurements of heart rate and lactate production show marked differences from the profound diving response induced by forced immersion .", + "entities": [ + "myoglobin" + ] + }, + { + "id": "11185", + "type": "gene", + "text": "The two main experimental variables were the attended hemifield ( left or right ) and the proportion of trials requiring a shift within that hemifield ( 20 % or 80 % ) .", + "entities": [] + }, + { + "id": "11186", + "type": "gene", + "text": "Of 165 women with non - malignant diagnoses 26 ( 16 % ) had CA 125 levels in excess of 35 U / ml and 8 ( 5 % ) greater than 65 U / ml .", + "entities": [ + "CA 125" + ] + }, + { + "id": "11187", + "type": "gene", + "text": "EMSA competition experiments showed that mutations within the direct repeats failed to compete for binding of the nuclear proteins to labeled wild type oligonucleotide .", + "entities": [] + }, + { + "id": "11188", + "type": "gene", + "text": "Our results suggest that Anu2p is the yeast homologue of mammalian epsilon - COP and the abrupt accumulation of the ER membrane caused by a blockage of the early protein transport pathway leads to alteration of nuclear morphology of the budding yeast cells .", + "entities": [ + "Anu2p", + "yeast homologue of mammalian epsilon - COP" + ] + }, + { + "id": "11189", + "type": "gene", + "text": "When RNA encoding the tail domain of desmoglein was coinjected with plakoglobin RNA , both the dorsalizing effect and nuclear accumulation of plakoglobin were suppressed .", + "entities": [ + "desmoglein", + "plakoglobin RNA", + "plakoglobin" + ] + }, + { + "id": "11190", + "type": "gene", + "text": "Using reference probes as internal standards , we show that the ost transcription unit is located within the cytogenetic band interval 89A1 , 2 on the right arm of the third chromosome , and that it exerts diagnostic segmentation gene expression patterns in the embryo .", + "entities": [ + "ost transcription unit" + ] + }, + { + "id": "11191", + "type": "gene", + "text": "The N - terminal portion of Notch ( IC ) inhibited p50 DNA binding and interacted specifically with p50 subunit , not p65 of NF - kappaB .", + "entities": [ + "Notch ( IC )", + "p50", + "p50 subunit", + "p65", + "NF - kappaB" + ] + }, + { + "id": "11192", + "type": "gene", + "text": "CSR is directed to specific heavy chain isotypes by cytokines and B cell activators that induce transcription from the unrearranged , or germline ( GL ) , C ( H ) region genes .", + "entities": [ + "C ( H ) region genes" + ] + }, + { + "id": "11193", + "type": "gene", + "text": "Hence , the uPA promoter contains multiple weak cis - acting elements distributed over 7 . 0 kb 5 ' to the translation start site .", + "entities": [ + "uPA promoter" + ] + }, + { + "id": "11194", + "type": "gene", + "text": "E3 / 19K resides in the endoplasmic reticulum where it binds to MHC class I molecules , thereby preventing their transport to the cell surface .", + "entities": [ + "E3 / 19K", + "MHC class I molecules" + ] + }, + { + "id": "11195", + "type": "gene", + "text": "Moreover , a complex containing PTP phi , paxillin , and a paxillin - associated tyrosine kinase , Pyk2 , can be immunoprecipitated from macrophage lysates , and the catalytic domain of PTP phi selectively binds paxillin and Pyk2 in vitro .", + "entities": [ + "PTP phi", + "paxillin", + "paxillin - associated tyrosine kinase", + "Pyk2", + "PTP phi", + "paxillin", + "Pyk2" + ] + }, + { + "id": "11196", + "type": "gene", + "text": "It was found that the ROSP undergoes a number of fluctuations in the negative and positive directions with a gradually decreasing amplitude in the course of 5 - 25 days following the operation , after which relatively stable negative values of the ROSP are established on the average in electrodes implanted to the level of the dura mater , and positive values in electrodes implanted to the level of the pia mater .", + "entities": [] + }, + { + "id": "11197", + "type": "gene", + "text": "Among individuals , however , changes were strongly correlated with ACR levels at baseline .", + "entities": [] + }, + { + "id": "11198", + "type": "gene", + "text": "Leukocyte enzyme activity and blood lymphocyte blast transformation in chronic bronchitis", + "entities": [] + }, + { + "id": "11199", + "type": "gene", + "text": "The goal of this study was to identify neuronal cell cultures that express RC3 / neurogranin , to check whether they are sensitive to T3 , and to examine the mechanism of regulation .", + "entities": [ + "RC3", + "neurogranin" + ] + }, + { + "id": "11200", + "type": "gene", + "text": "Antibodies against this purified protein localize RIM1 to mitochondria .", + "entities": [ + "RIM1" + ] + }, + { + "id": "11201", + "type": "gene", + "text": "Acid instilled on the larynx of maturing rabbits resulted in significant obstructive , central , and mixed apnea .", + "entities": [] + }, + { + "id": "11202", + "type": "gene", + "text": "In 2 subjects the phytomitogen reactivity of the lymphocytes was improved after treatment .", + "entities": [] + }, + { + "id": "11203", + "type": "gene", + "text": "When pollen allergen from three grass species were used , The RAST - test results did not differ from duplicate values either .", + "entities": [] + }, + { + "id": "11204", + "type": "gene", + "text": "The ESEG ' s are a direct result of the NEXT study .", + "entities": [] + }, + { + "id": "11205", + "type": "gene", + "text": "The child left behind .", + "entities": [] + }, + { + "id": "11206", + "type": "gene", + "text": "Autotransfusion was performed as follows : Heparin - ACD - B - Heparin - DPD - Heparin - ACD - B etc .", + "entities": [] + }, + { + "id": "11207", + "type": "gene", + "text": "Concerted transcriptional activation of the low density lipoprotein receptor gene by insulin and luteinizing hormone in cultured porcine granulosa - luteal cells : possible convergence of protein kinase a , phosphatidylinositol 3 - kinase , and mitogen - activated protein kinase signaling pathways .", + "entities": [ + "low density lipoprotein receptor gene", + "insulin", + "luteinizing hormone", + "protein kinase a", + "phosphatidylinositol 3 - kinase", + "mitogen - activated protein kinase" + ] + }, + { + "id": "11208", + "type": "gene", + "text": "The cost per test is less than those for CC , kEIA and PACE2 .", + "entities": [] + }, + { + "id": "11209", + "type": "gene", + "text": "RT - PCR using 1 . D - specific primers showed that kidney , brain and prostate do not express 1 . D mRNA even though kidney and brain are the most abundant source for aFGF protein .", + "entities": [ + "aFGF protein" + ] + }, + { + "id": "11210", + "type": "gene", + "text": "Demispan is a reliable and reproducible measure of stature in the elderly .", + "entities": [] + }, + { + "id": "11211", + "type": "gene", + "text": "The addition of culture to the CC and CC : SW by - products resulted in pH values lower ( P < 0 . 05 ) than those without culture on Day 21 , and the 15 % carbohydrate treatment significantly reduced pH beyond the 5 % carbohydrate .", + "entities": [] + }, + { + "id": "11212", + "type": "gene", + "text": "Gap b3 consists of two polypeptide chains ( Mr = 110 , 000 and 30 , 000 ) , which seem to be proteolytic cleavage products connected by disulfide bonds from a precursor protein .", + "entities": [ + "Gap b3" + ] + }, + { + "id": "11213", + "type": "gene", + "text": "Vancomycin data were analyzed according to a one - compartment open model with use of NONMEM population pharmacokinetic software .", + "entities": [] + }, + { + "id": "11214", + "type": "gene", + "text": "The second mutation present in the original mutant proved to be an allele of a known gene , PBS2 , which encodes a putative protein kinase that functions in the high osmolarity stress pathway .", + "entities": [ + "PBS2" + ] + }, + { + "id": "11215", + "type": "gene", + "text": "There were 45 to 56 nt differences between the virulent and avirulent groups while there were 6 to 14 nt differences among four avirulent strains .", + "entities": [] + }, + { + "id": "11216", + "type": "gene", + "text": "The genome of all retroviruses consists of two identical RNAs noncovalently linked near their 5 ' end .", + "entities": [] + }, + { + "id": "11217", + "type": "gene", + "text": "As opposed to in vitro co - precipitation studies , the yeast two - hybrid screen reveals in vivo protein - protein interactions .", + "entities": [] + }, + { + "id": "11218", + "type": "gene", + "text": "In this manuscript we demonstrate that two tandem Ets sites in the mouse GL alpha promoter bind the transcription factors Elf - 1 and PU . 1 , and that the 3 ' site is essential for expression of a luciferase reporter gene driven by the GL alpha promoter .", + "entities": [ + "tandem Ets sites", + "mouse GL alpha promoter", + "transcription factors Elf - 1", + "PU . 1", + "luciferase reporter gene", + "GL alpha promoter" + ] + }, + { + "id": "11219", + "type": "gene", + "text": "Both neural and hormonal pathways and both opiate and nonopiate substances play roles in the complex modulation of pain transmission .", + "entities": [] + }, + { + "id": "11220", + "type": "gene", + "text": "Furthermore , a mutant receptor ( Y977F / Y989F [ PLC gamma - binding sites ] ) could fully activate Ras , and the direct activation of protein kinase C and calcium mobilization had almost no effect on the GDP / GTP state of Ras in this cell line .", + "entities": [ + "PLC gamma", + "Ras", + "protein kinase C", + "Ras" + ] + }, + { + "id": "11221", + "type": "gene", + "text": "Most pituitary hormone - coding gene promoters are activated by Ptx1 .", + "entities": [ + "Ptx1" + ] + }, + { + "id": "11222", + "type": "gene", + "text": "Krox - 20 , a zinc finger gene , has a highly conserved pattern of expression in r3 and r5 and is functionally required for their maintenance in mouse embryos .", + "entities": [ + "Krox - 20", + "zinc finger gene" + ] + }, + { + "id": "11223", + "type": "gene", + "text": "Moreover , exons 2a and 2b share the same 5 ' sequence but differ from each other by the use of two distinct donor splice sites 171 bp apart in the gene .", + "entities": [] + }, + { + "id": "11224", + "type": "gene", + "text": "A subsequent screen for the loss of the positively selectable target locus marker detects the desired replacement at modest frequency ( > 2 % ) .", + "entities": [] + }, + { + "id": "11225", + "type": "gene", + "text": "Both BG and IRI concentrations during the OGTT were the lowest in body builders , medium in controls , and the highest in obese men .", + "entities": [ + "IRI" + ] + }, + { + "id": "11226", + "type": "gene", + "text": "The TAF factor appears to be particularly significant in OCD .", + "entities": [] + }, + { + "id": "11227", + "type": "gene", + "text": "The resulting mutants were coexpressed with gE in the vaccinia virus - based vTF7 - 3 system , and the formation and endoplasmic reticulum ( ER ) - to - Golgi transport of the hetero - oligomeric complex were monitored .", + "entities": [ + "gE" + ] + }, + { + "id": "11228", + "type": "gene", + "text": "Natl .", + "entities": [] + }, + { + "id": "11229", + "type": "gene", + "text": "Analysis of functional domains of Arix reveals an N - terminal activation domain and a C - terminal repression domain .", + "entities": [ + "Arix" + ] + }, + { + "id": "11230", + "type": "gene", + "text": "The location of the IBS within the catB structural gene , the cooperativity observed in footprinting studies and phasing studies suggest that the IBS participates in the interaction of CatR with the upstream binding sites by looping out the intervening DNA .", + "entities": [ + "catB structural gene", + "CatR" + ] + }, + { + "id": "11231", + "type": "gene", + "text": "In addition , benzocaine and 2 - phenoxyethanol depressed complement activity and phagocytosis , while MS222 and quinaldine sulphate did not .", + "entities": [] + }, + { + "id": "11232", + "type": "gene", + "text": "Analyses of additional tumors induced in mice from two reciprocal crosses , A / J x C3H / HeJ F1 ( hereafter called AC3F1 ) and C3H / HeJ x A / J F1 ( hereafter called C3AF1 ) , provided evidence for the inactivation of one allele of the putative chromosome 4 tumor suppressor gene by parental imprinting .", + "entities": [] + }, + { + "id": "11233", + "type": "gene", + "text": "Identification of Ste4 as a potential regulator of Byr2 in the sexual response pathway of Schizosaccharomyces pombe .", + "entities": [ + "Ste4", + "Byr2" + ] + }, + { + "id": "11234", + "type": "gene", + "text": "Radiolabelled palmitate was not incorporated into the mutated protein , showing that lipid modification occurs at the Cys - 22 residue .", + "entities": [] + }, + { + "id": "11235", + "type": "gene", + "text": "PSI - G and PSI - K probably have evolved from a gene duplication of an ancestral gene .", + "entities": [ + "PSI - G", + "PSI - K" + ] + }, + { + "id": "11236", + "type": "gene", + "text": "Immunity acquired by mice during I . scapularis nymphal activity in early summer may exclude a large proportion of the mouse population from maintaining E . phagocytophila during the period of larval activity later in the season .", + "entities": [] + }, + { + "id": "11237", + "type": "gene", + "text": "The color - word interference effect previously reported with normal populations when given the Stroop test was demonstrated for this retarded sample using a special format .", + "entities": [] + }, + { + "id": "11238", + "type": "gene", + "text": "TBPf is defined as a quotient of the difference of the first and the second measurement : TBPf = ( P1 - P2 ) / ( A1 - A2 ) .", + "entities": [] + }, + { + "id": "11239", + "type": "gene", + "text": "The Saccharomyces cerevisiae 14DM gene , encoding cytochrome P450 lanosterol 14 alpha - demethylase ( 14DM ) , was overexpressed in various S . cerevisiae strains under the control of three strong heterologous yeast transcription promoters ( pADC1 , pGPD , pPHO5 ) and under the control of its own promoter .", + "entities": [ + "Saccharomyces cerevisiae 14DM gene", + "cytochrome P450 lanosterol 14 alpha - demethylase", + "14DM", + "pADC1", + "pGPD", + "pPHO5" + ] + }, + { + "id": "11240", + "type": "gene", + "text": "Toxicities included : nausea / vomiting ( 69 % ) , headache ( 25 % ) , chills ( 69 % ) , pain at tumor sites ( 63 % ) , hypotension ( 31 % ) , and hypertension ( 38 % ) .", + "entities": [] + }, + { + "id": "11241", + "type": "gene", + "text": "In nucleus ventralis anterior thalami - nucleus ventralis lateralis thalami neurons with an inhibitory input from nucleus entopeduncularis , a shortening of inhibition from 17 . 5 + / - 3 . 6 to 9 . 1 + / - 1 . 8 ms ( P < 0 . 05 ) under the haloperidol influence was evident .", + "entities": [] + }, + { + "id": "11242", + "type": "gene", + "text": "In Trial 1 , eight sows were allowed to farrow naturally ( d 114 , NF sows ) and eight sows were induced to farrow ( IF sows ) prematurely by injection of prostaglandin F2 alpha on d 112 of gestation .", + "entities": [] + }, + { + "id": "11243", + "type": "gene", + "text": "The genomic structure of brk consists of 8 exons , whose boundaries are distinct from other non - receptor PTK family members , again indicating a structural and functional divergence .", + "entities": [ + "brk", + "PTK family" + ] + }, + { + "id": "11244", + "type": "gene", + "text": "Dll3 is mutated in the X - ray - induced mouse mutant pudgy ( pu ) , causing a variety of vertebrocostal defects similar to SD phenotypes .", + "entities": [ + "Dll3", + "mouse mutant pudgy", + "pu" + ] + }, + { + "id": "11245", + "type": "gene", + "text": "Switching FDC - P1 / MAC cells from growth in M - CSF to GM - CSF caused the selective degradation of c - fms mRNA within 6 h after factor switching .", + "entities": [ + "M - CSF", + "GM - CSF", + "c - fms mRNA" + ] + }, + { + "id": "11246", + "type": "gene", + "text": "Human ZFM1 protein is a transcriptional repressor that interacts with the transcription activation domain of stage - specific activator protein .", + "entities": [ + "ZFM1 protein", + "transcription activation domain of stage - specific activator protein" + ] + }, + { + "id": "11247", + "type": "gene", + "text": "Tissues and exudates contain sufficient thymidine for growth of anaerobic bacteria in the presence of inhibitory levels of trimethoprim - sulfamethoxazole .", + "entities": [] + }, + { + "id": "11248", + "type": "gene", + "text": "Lack of effect of the appetite stimulant pizotifen ( BC 105 ) on the absorption of isonicotinylhydrazine .", + "entities": [] + }, + { + "id": "11249", + "type": "gene", + "text": "We now describe a second RIM protein , called RIM2 , that is highly homologous to RIM1 and also expressed primarily in brain .", + "entities": [ + "RIM protein", + "RIM2", + "RIM1" + ] + }, + { + "id": "11250", + "type": "gene", + "text": "These results strongly suggested that similar , if not identical , the CArG box binding proteins interact with the functionally different promoter element in the VLC1 , cardiac alpha - actin , and c - fos genes .", + "entities": [ + "CArG box binding proteins", + "VLC1", + "cardiac alpha - actin", + "c - fos genes" + ] + }, + { + "id": "11251", + "type": "gene", + "text": "Exon A is located approximately 7 kb 5 ' to the HSL translation start site .", + "entities": [ + "HSL translation start site" + ] + }, + { + "id": "11252", + "type": "gene", + "text": "Oxygen delivery and base excess decreased significantly and four pigs died .", + "entities": [] + }, + { + "id": "11253", + "type": "gene", + "text": "Neither model , as applied , provided a satisfactory account of the effects of the main variables of number of tones and amount of perturbation . ( ABSTRACT TRUNCATED AT 400 WORDS )", + "entities": [] + }, + { + "id": "11254", + "type": "gene", + "text": "The kallistatin gene was localized by in situ hybridization to human chromosome 14q31 - q32 . 1 , close to the serpin genes encoding alpha 1 - antichymotrypsin , protein C inhibitor , alpha 1 - antitrypsin , and corticosteroid - binding globulin .", + "entities": [ + "kallistatin gene", + "serpin genes", + "alpha 1 - antichymotrypsin", + "protein C inhibitor", + "alpha 1 - antitrypsin", + "corticosteroid - binding globulin" + ] + }, + { + "id": "11255", + "type": "gene", + "text": "Our data complement other studies of circumpolar populations and reinforce the reported high prevalences of SPA and HLA - B27 among those populations .", + "entities": [ + "HLA - B27" + ] + }, + { + "id": "11256", + "type": "gene", + "text": "The liver in the severely ill", + "entities": [] + }, + { + "id": "11257", + "type": "gene", + "text": "These results demonstrate that tip acts at an early stage of the T - cell signal transduction cascade by associating with Lck and downregulating Lck - mediated activation .", + "entities": [ + "tip", + "Lck" + ] + }, + { + "id": "11258", + "type": "gene", + "text": "At least one clone , lambda HHG 41 , contains , in addition to the histone genes , a region that hybridizes with a cytoplasmic RNA approximately 330 nucleotides in length .", + "entities": [ + "histone genes" + ] + }, + { + "id": "11259", + "type": "gene", + "text": "Phosphopeptide mapping revealed the same autophosphorylation sites utilized by EGFR - IC as those identified in wild - type EGFR .", + "entities": [ + "EGFR - IC", + "wild - type EGFR" + ] + }, + { + "id": "11260", + "type": "gene", + "text": "Changes in prognosis of twin births over 20 years .", + "entities": [] + }, + { + "id": "11261", + "type": "gene", + "text": "During the past 4 years , a purposeful search was made for electrocardiograms with documented reversible QRS changes associated with all acute injury pattern .", + "entities": [] + }, + { + "id": "11262", + "type": "gene", + "text": "The beta chain contains five potential N - linked glycosylation sites , and endoglycosidase digestion suggested that the beta chain contained multiple complex carbohydrate side chains .", + "entities": [ + "endoglycosidase" + ] + }, + { + "id": "11263", + "type": "gene", + "text": "An immunologically related protein was detected in ribosome and membrane fractions of mitochondria from Saccharomyces cerevisiae .", + "entities": [] + }, + { + "id": "11264", + "type": "gene", + "text": "The prevalence of hepatitis B surface antigen ( HBsAg ) and anti - HBs was determined by a sensitive double - antibody radio - immunoassay technique in a series of patients with chronic liver diseases .", + "entities": [ + "hepatitis B surface antigen", + "HBsAg", + "anti - HBs" + ] + }, + { + "id": "11265", + "type": "gene", + "text": "Patients were randomly assigned to treatment with the ACE inhibitor perindopril ( and the diuretic indapamide for those with no definite indication for or contraindication to treatment with a diuretic ) or matching placebo ( s ) .", + "entities": [ + "ACE" + ] + }, + { + "id": "11266", + "type": "gene", + "text": "These data suggest that spontaneous recovery of central respiratory function after intoxication with Soman or Sarin may not be related to the return of AChE activity .", + "entities": [ + "AChE" + ] + }, + { + "id": "11267", + "type": "gene", + "text": "The nucleotide sequences at the 5 ' and 3 ' ends of these introns are characteristic of spliced transcripts from eukaryotic protein - encoding genes , with one significant difference ; i . e . , the 5 ' end of the LAT intron is GC instead of the consensus sequence GT .", + "entities": [ + "LAT intron" + ] + }, + { + "id": "11268", + "type": "gene", + "text": "We suggest that CT scan be preferable in diagnosis of tumors in that area .", + "entities": [] + }, + { + "id": "11269", + "type": "gene", + "text": "The inserted region , which represents an intron in brain and muscle , is expressed in the tumor cell lines either as a \" readthrough \" form or with 78 residues deleted from its 5 ' end .", + "entities": [] + }, + { + "id": "11270", + "type": "gene", + "text": "The magnitude of the early response was 241 + / - 51 % in A ( % baseline RL ; mean + / - SE ) , and significantly less in B ( 119 + / - 7 % ) and C ( 131 + / - 16 % ) ( p < 0 . 01 ) .", + "entities": [] + }, + { + "id": "11271", + "type": "gene", + "text": "The outcome of the optimization of the seven - field plan prompted an investigation into the best results that could be achieved by an \" ideal \" conformal radiotherapy technique .", + "entities": [] + }, + { + "id": "11272", + "type": "gene", + "text": "For this reason , the particle forming capacity of derivatives of the HIV - 1 group specific core antigen p55 gag was assayed and compared dependent on various expression systems : recombinant bacteria , vaccinia - and baculoviruses were established encoding the entire core protein p55 either in its authentic sequence or lacking the myristylation consensus signal .", + "entities": [ + "HIV - 1 group specific core antigen p55 gag", + "core protein p55" + ] + }, + { + "id": "11273", + "type": "gene", + "text": "Chemical histologic and immunologic responses in rats to CC1 - 4 by different routes of administration .", + "entities": [] + }, + { + "id": "11274", + "type": "gene", + "text": "CONCLUSIONS : These results show that once daily oral valganciclovir can produce exposures of ganciclovir ( AUC24 ) exceeding those attained using intravenous ganciclovir 10 mg / kg .", + "entities": [] + }, + { + "id": "11275", + "type": "gene", + "text": "Similarly , curcumin ( diferuloylmethane ) , an anti - inflammatory agent , suppressed OSM - stimulated STAT1 phosphorylation , DNA - binding activity of STAT1 , and c - Jun N - terminal kinase activation without affecting JAK1 , JAK2 , JAK3 , ERK1 / 2 , and p38 phosphorylation .", + "entities": [ + "OSM", + "STAT1", + "STAT1", + "c - Jun N - terminal kinase", + "JAK1", + "JAK2", + "JAK3", + "ERK1 / 2", + "p38" + ] + }, + { + "id": "11276", + "type": "gene", + "text": "The results corroborate the idea that the structure of relaxation curves contains information on the distance scale and on the architecture of the pore space , even if it is difficult to extract it without ambiguities .", + "entities": [] + }, + { + "id": "11277", + "type": "gene", + "text": "The study enrolled 994 people co - infected with CMV and HIV , with at least one CD4 count recorded < 100 x 10 ( 6 ) cells / l .", + "entities": [ + "CD4" + ] + }, + { + "id": "11278", + "type": "gene", + "text": "If NCR - sensitive gene expression occurs exclusively by this pathway , as has been thought to be the case , then the NCR sensitivity of a gene ' s expression should be abolished by a ure2 delta mutation .", + "entities": [ + "ure2 delta mutation" + ] + }, + { + "id": "11279", + "type": "gene", + "text": "Human MGP is a 10 - kD skeletal extracellular matrix ( ECM ) protein that consists of an 84 - aa mature protein and a 19 - aa transmembrane signal peptide .", + "entities": [ + "Human MGP", + "10 - kD skeletal extracellular matrix ( ECM ) protein" + ] + }, + { + "id": "11280", + "type": "gene", + "text": "We examined behavioral alterations in the brown cockroach , Periplaneta brunnea , infected with the acanthocephalan , Moniliformis moniliformis .", + "entities": [] + }, + { + "id": "11281", + "type": "gene", + "text": "Behavior of aspartate aminotransferase ( EC 2 . 6 . 1 . 1 ) and alanine aminotransferase ( EC 2 . 6 . 1 . 2 ) in rat serum during the course of acute radiation syndrome following whole body X - irradiation", + "entities": [ + "aspartate aminotransferase", + "EC 2 . 6 . 1 . 1", + "alanine aminotransferase", + "EC 2 . 6 . 1 . 2" + ] + }, + { + "id": "11282", + "type": "gene", + "text": "Neuron - specific Bcl - 2 homology 3 domain - only splice variant of Bak is anti - apoptotic in neurons , but pro - apoptotic in non - neuronal cells .", + "entities": [ + "Neuron - specific Bcl - 2 homology 3 domain - only splice variant", + "Bak" + ] + }, + { + "id": "11283", + "type": "gene", + "text": "Therefore , mechanisms that control activation of the MAP kinase cascade temporally and spatially may be important for specification of cellular responses .", + "entities": [ + "MAP kinase" + ] + }, + { + "id": "11284", + "type": "gene", + "text": "Several particular features of this polypeptide fragment from the hamster lysyl - tRNA synthetase suggest that it is implicated in the assembly of that enzyme within the multisynthetase complex .", + "entities": [ + "hamster lysyl - tRNA synthetase" + ] + }, + { + "id": "11285", + "type": "gene", + "text": "Goodpasture ' s - like syndrome and effect of extracorporeal membrane oxygenator support .", + "entities": [] + }, + { + "id": "11286", + "type": "gene", + "text": "Liver microsomes of the shag showed smaller than 8 % of the epoxide hydrase activity and smaller than 14 % of the hydroxylating capacity of liver microsomes from the rat .", + "entities": [ + "epoxide hydrase" + ] + }, + { + "id": "11287", + "type": "gene", + "text": "It is now recognized that essentially all eukaryotic and prokaryotic genes whose 5 ' - flanking regions are known and that encode barbiturate - inducible proteins contain the Barbie box element .", + "entities": [] + }, + { + "id": "11288", + "type": "gene", + "text": "Interestingly , an increase of distance per se did not have a deleterious effect on translation efficiency .", + "entities": [] + }, + { + "id": "11289", + "type": "gene", + "text": "Localized fluorescence was detectable only in cells containing a visible midcell constriction , suggesting that FtsK targeting normally occurs only at a late stage of septation .", + "entities": [ + "FtsK" + ] + }, + { + "id": "11290", + "type": "gene", + "text": "S . , Kim , S .", + "entities": [] + }, + { + "id": "11291", + "type": "gene", + "text": "The unexpected presence of the tRNA ( trp ) ( CCA ) - gene transcript in mitochondria is also reported .", + "entities": [ + "tRNA ( trp ) ( CCA ) - gene transcript in mitochondria" + ] + }, + { + "id": "11292", + "type": "gene", + "text": "Amyloid beta - protein ( Abeta ) is the main constituent of amyloid fibrils found in senile plaques and cerebral vessels in Alzheimer ' s disease ( AD ) and is derived by proteolysis from the beta - amyloid precursor protein ( APP ) .", + "entities": [ + "Amyloid beta - protein", + "Abeta", + "beta - amyloid precursor protein", + "APP" + ] + }, + { + "id": "11293", + "type": "gene", + "text": "A23187 did not induce any modifications of the endolymphatic potential , the ampullar direct current or the frequency of the evoked afferent spikes .", + "entities": [] + }, + { + "id": "11294", + "type": "gene", + "text": "In the adult mouse , ERR alpha is most highly expressed in kidney , heart , and brown adipocytes , tissues which preferentially metabolize fatty acids .", + "entities": [ + "ERR alpha" + ] + }, + { + "id": "11295", + "type": "gene", + "text": "Component P100 was associated with a frontal negativity of similar latency favoring the hypothesis of a dipolar occipital generator .", + "entities": [] + }, + { + "id": "11296", + "type": "gene", + "text": "G - box - directed expression in leaves required the presence of an enhancer region from the cauliflower mosaic virus ( CaMV ) 35S promoter .", + "entities": [ + "35S promoter" + ] + }, + { + "id": "11297", + "type": "gene", + "text": "Vertebrate synapsins constitute a family of synaptic proteins that participate in the regulation of neurotransmitter release .", + "entities": [ + "Vertebrate synapsins" + ] + }, + { + "id": "11298", + "type": "gene", + "text": "In this report , we describe the characterization of two early class II flagellar genes contained in the orfX - fliP locus .", + "entities": [ + "class II flagellar genes", + "fliP" + ] + }, + { + "id": "11299", + "type": "gene", + "text": "Results from our and other laboratories have suggested that UCN - 01 induces preferential G1 - phase accumulation in several human tumor cell lines tested .", + "entities": [] + }, + { + "id": "11300", + "type": "gene", + "text": "Small - molecule control of insulin and PDGF receptor signaling and the role of membrane attachment .", + "entities": [ + "insulin", + "PDGF receptor" + ] + }, + { + "id": "11301", + "type": "gene", + "text": "The gene encoding IFN - gamma was previously found to contain an intronic enhancer element that was not tissue - specific in its activity , despite the restricted expression of the intact IFN - gamma - encoding gene .", + "entities": [ + "IFN - gamma", + "IFN - gamma - encoding gene" + ] + }, + { + "id": "11302", + "type": "gene", + "text": "The results indicate that the bradycardic agents alinidine and zatebradine do not exert antiarrhythmic efficacy against SVT induced during subacute myocardial infarction in conscious dogs .", + "entities": [] + }, + { + "id": "11303", + "type": "gene", + "text": "To the problem of the stimulation of the growth of transplantable tumors of animals previously treated with antineoplastic antibiotics", + "entities": [] + }, + { + "id": "11304", + "type": "gene", + "text": "By using lacZ fusions , it was possible to localize the DNA sequences required to mediate nitrate repression to the pfl promoter - regulatory region .", + "entities": [ + "lacZ fusions", + "pfl promoter - regulatory region" + ] + }, + { + "id": "11305", + "type": "gene", + "text": "References for occupational fitness of adolescents with diseases of the respiratory tract and lungs", + "entities": [] + }, + { + "id": "11306", + "type": "gene", + "text": "The reason that nitrous oxide does not produce hydroxyl radicals readily might be that the one - electron reduction proceeds through an N2O - intermediate which is energetically very unfavourable : EO ( N2O / N2O - ) = - 1 . 1 V .", + "entities": [] + }, + { + "id": "11307", + "type": "gene", + "text": "It was postulated that persistent challenge by M . leprae or its antigens to the IgA immunocytes of the intestinal epithelium might have induced tolerance leading to IgA deficiency and subsequent subtotal atrophy of the intestinal villi in the patients with lepromatous leprosy .", + "entities": [ + "IgA", + "IgA" + ] + }, + { + "id": "11308", + "type": "gene", + "text": "Directives concerning medical care", + "entities": [] + }, + { + "id": "11309", + "type": "gene", + "text": "Alanine aminotransferase in clinical practice .", + "entities": [ + "Alanine aminotransferase" + ] + }, + { + "id": "11310", + "type": "gene", + "text": "This scFv was therefore used as control in experiments where another anti - Ras scFv ( Y259 scFv , derived from the neutralizing anti - Ras mAb Y13 - 259 ) blocked the Ras pathway in vitro and led to tumor regression in a nude mouse model [ Cochet , O . , Kenigsberg , M . , Delumeau , I . , Virone - Oddos , A . , Multon , M . C . , Fridman , W . H . , Schweighoffer , F . , Teillaud , J . L . , Tocque , B . , 1998 .", + "entities": [ + "anti - Ras scFv", + "Y259 scFv", + "anti - Ras mAb Y13 - 259", + "Ras" + ] + }, + { + "id": "11311", + "type": "gene", + "text": "M .", + "entities": [] + }, + { + "id": "11312", + "type": "gene", + "text": "The hypothesis of Geisler ( Brain Res .", + "entities": [] + }, + { + "id": "11313", + "type": "gene", + "text": "PURPOSE : To introduce an image analysis of the cornea in photorefractive keratectomy ( PRK ) for preoperative and early postoperative determination of changes in the condition of the cornea .", + "entities": [] + }, + { + "id": "11314", + "type": "gene", + "text": "In general lookback , all patients who received blood before being tested for hepatitis C are advised to undergo testing .", + "entities": [] + }, + { + "id": "11315", + "type": "gene", + "text": "Two cases with marked chronic arm lymphoedema reported major and persistent improvements in arm volume for at least 12 months after treatment with HBO2 .", + "entities": [] + }, + { + "id": "11316", + "type": "gene", + "text": "Mutational studies provide evidence to this end and indicate that the side chains of subdomain 4 . 2 make specific contacts with the nucleotides at - 35 .", + "entities": [] + }, + { + "id": "11317", + "type": "gene", + "text": "Band - shift assays and DNase I footprinting experiments using purified 42 kDa repressor isoform confirmed that CIRs 5 and 6 were indeed the targets for binding of this protein .", + "entities": [ + "DNase I", + "CIRs 5 and 6" + ] + }, + { + "id": "11318", + "type": "gene", + "text": "Following the satisfactory results and taking into account that the complications had reduced to a very low rate ( in 2 cases lead tip displacement and pouch haematoma occurred respectively ) , the Authors consider the adopted method an useful approach for PMK implantation particularly when the use of the vena cephalica is deemed impossible .", + "entities": [] + }, + { + "id": "11319", + "type": "gene", + "text": "Unlike the MAR - binding domain , the homeodomain when isolated binds poorly and with low specificity to DNA .", + "entities": [ + "homeodomain" + ] + }, + { + "id": "11320", + "type": "gene", + "text": "Full thyroid function testing was performed on 600 randomly selected samples with normal TSH values and also on subjects with abnormal TSH levels .", + "entities": [ + "TSH", + "TSH" + ] + }, + { + "id": "11321", + "type": "gene", + "text": "These are two regions of known conserved synteny , providing further evidence that the human STEP is a true homolog of the murine STEP gene .", + "entities": [ + "human STEP", + "murine STEP gene" + ] + }, + { + "id": "11322", + "type": "gene", + "text": "Jerseys had higher hepatic Cu concentrations than did Holsteins on d 60 ( 346 vs .", + "entities": [] + }, + { + "id": "11323", + "type": "gene", + "text": "In the yeast Saccharomyces cerevisiae , copper levels exert some control over the level of SOD1 expression .", + "entities": [ + "SOD1" + ] + }, + { + "id": "11324", + "type": "gene", + "text": "RESULTS : No significant deformation in vertebral artery flow was noted in the flexion - distraction Stage I injuries within the physiologic range of cervical flexion .", + "entities": [] + }, + { + "id": "11325", + "type": "gene", + "text": "No homology was found between RNA14 and RNA15 or between RNA14 and other proteins contained in data banks .", + "entities": [ + "RNA14", + "RNA15", + "RNA14" + ] + }, + { + "id": "11326", + "type": "gene", + "text": "Ischemic stroke due to protein C deficiency .", + "entities": [ + "protein C" + ] + }, + { + "id": "11327", + "type": "gene", + "text": "Degenerate primers homologous to highly conserved regions of known CYP3A sequences were used for initial RT - PCRs .", + "entities": [ + "CYP3A sequences" + ] + }, + { + "id": "11328", + "type": "gene", + "text": "In the course of screening for transcription factors which interact with the human myeloperoxidase ( MPO ) promoter we , for the first time , identified and cloned the cDNA and genomic DNA for human HBP1 ( HMG - Box containing protein 1 ) , a member of the high mobility group of non - histone chromosomal proteins .", + "entities": [ + "human myeloperoxidase", + "MPO", + "human HBP1", + "HMG - Box containing protein 1", + "high mobility group of non - histone chromosomal proteins" + ] + }, + { + "id": "11329", + "type": "gene", + "text": "A single five minute period of rapid atrial pacing fails to limit infarct size in the in situ rabbit heart .", + "entities": [] + }, + { + "id": "11330", + "type": "gene", + "text": "4 .", + "entities": [] + }, + { + "id": "11331", + "type": "gene", + "text": "The GHR mRNA : GHBP mRNA ratio was 1 . 1 + / - 0 . 12 and remained unchanged during differentiation .", + "entities": [ + "GHR mRNA", + "GHBP mRNA" + ] + }, + { + "id": "11332", + "type": "gene", + "text": "This organization suggests that duplication events that have generated the primate FUT3 - FUT5 - FUT6 cluster might have occurred through a long - interspersed - nuclear - element - based mechanism of unequal crossing over , as described for the globin cluster .", + "entities": [ + "FUT3", + "FUT5", + "FUT6", + "globin cluster" + ] + }, + { + "id": "11333", + "type": "gene", + "text": "However , the beta5L splice variant was found only in the retina .", + "entities": [] + }, + { + "id": "11334", + "type": "gene", + "text": "At physiological doses , either insulin - like growth factor I ( IGF - I ) or insulin turned out to be as potent as dibutyryl cAMP ( dbcAMP ) in increasing UCP1 gene transcription rate ( 1 h ) and also UCP1 mRNA accumulation ( 3 h ) , their maximal effect ( 15 - fold increase ) reached upon treatment for 24 h .", + "entities": [ + "insulin - like growth factor I", + "IGF - I", + "insulin", + "UCP1 gene", + "UCP1 mRNA" + ] + }, + { + "id": "11335", + "type": "gene", + "text": "The extended rat SP - A isoforms were enriched in the more fully glycosylated and multimeric SP - A species separated on SDS - PAGE gels .", + "entities": [ + "rat SP - A isoforms", + "SP - A" + ] + }, + { + "id": "11336", + "type": "gene", + "text": "Metabolic labeling studies in S . cerevisiae and co - expression of nmt72p with several protein substrates of Nmt1p in Escherichia coli indicate that the Leu99 - - > Pro substitution causes a reduction in the acylation of some but not all protein substrates .", + "entities": [ + "nmt72p", + "Nmt1p" + ] + }, + { + "id": "11337", + "type": "gene", + "text": "The analysis of two distinct mitogen - activated protein kinase pathways shows that stress - activated protein kinase - Jun N - terminal kinase activation , resulting in the phosphorylation of ATF - 2 , c - Jun , and JunD , is required not only for the IL - 1 - but also for the TPA - dependent induction , while the extracellular signal - related kinase 1 ( ERK - 1 ) and ERK - 2 activation is involved in the TPA - but not in the IL - 1 - dependent stimulation of the uPA enhancer .", + "entities": [ + "mitogen - activated protein kinase", + "stress - activated protein kinase", + "Jun N - terminal kinase", + "ATF - 2", + "c - Jun", + "JunD", + "IL - 1", + "extracellular signal - related kinase 1", + "ERK - 1", + "ERK - 2", + "IL - 1", + "uPA enhancer" + ] + }, + { + "id": "11338", + "type": "gene", + "text": "Pharmacology studies with potassium chloride and acetylcholine suggest that raveron acts as a calcium antagonist by blocking the influx of extracellular calcium .", + "entities": [] + }, + { + "id": "11339", + "type": "gene", + "text": "Future analysis of long - term outcome measures of performance with the implant will confirm or dispute the benefit of ear selection using the Prom - EABR .", + "entities": [] + }, + { + "id": "11340", + "type": "gene", + "text": "The maximum deflections of phase IV for Ar and N2 from extrapolated phase III slopes were smaller in the prone position , suggesting more uniform tracer gas concentrations across the lungs .", + "entities": [] + }, + { + "id": "11341", + "type": "gene", + "text": "The single strandedness is manifested as a terminal extension of the G - rich strand ( G tails ) that can occur independently of telomerase , suggesting that cdc17 / pol1 mutants exhibit defects in telomeric lagging - strand synthesis .", + "entities": [ + "telomerase", + "cdc17", + "pol1" + ] + }, + { + "id": "11342", + "type": "gene", + "text": "Cloning , expression , and nucleotide sequence of rat liver sterol carrier protein 2 cDNAs .", + "entities": [ + "rat liver sterol carrier protein 2 cDNAs" + ] + }, + { + "id": "11343", + "type": "gene", + "text": "In summary , we conclude that the adenoviral oncoprotein E1A activates transcription from the endogenous AP - 2alpha gene , an effect that involves transcriptional derepression of the AP - 2alpha promoter by interaction of E1A with the AP - 2rep corepressor CtBP1 .", + "entities": [ + "E1A", + "AP - 2alpha gene", + "AP - 2alpha promoter", + "E1A", + "AP - 2rep", + "CtBP1" + ] + }, + { + "id": "11344", + "type": "gene", + "text": "The frequency of lactase phenotypes in Aymara children .", + "entities": [ + "lactase phenotypes" + ] + }, + { + "id": "11345", + "type": "gene", + "text": "The protein first identified by the monoclonal antibody Q18 is encoded by a gene located in 57A on polytene chromosomes and has been consequently named Hrb57A .", + "entities": [ + "monoclonal antibody Q18", + "Hrb57A" + ] + }, + { + "id": "11346", + "type": "gene", + "text": "These mutations alter two regions of GAL4 protein : the DNA binding domain , and the transcription activation domain .", + "entities": [ + "GAL4 protein" + ] + }, + { + "id": "11347", + "type": "gene", + "text": "A similar chimera was assembled from the two halves of the molecule expressed separately in different bacteria and refolded together .", + "entities": [] + }, + { + "id": "11348", + "type": "gene", + "text": "Both filters equally contributed to elevation of iliac venous pressure ( median , 9 . 3 and 7 . 2 mm Hg [ n = 9 ] with the spring filter and RF02 filter , respectively ) .", + "entities": [] + }, + { + "id": "11349", + "type": "gene", + "text": "Carbohydrates and glycoconjugates biophysical methods .", + "entities": [] + }, + { + "id": "11350", + "type": "gene", + "text": "The human U4 / U6 snRNP contains 60 and 90kD proteins that are structurally homologous to the yeast splicing factors Prp4p and Prp3p .", + "entities": [ + "U4", + "U6", + "Prp4p", + "Prp3p" + ] + }, + { + "id": "11351", + "type": "gene", + "text": "Morphological and functional alterations noted after baboon renal allotransplantation .", + "entities": [] + }, + { + "id": "11352", + "type": "gene", + "text": "Sequence analysis of cloned PCR products confirmed the presence of two different nifV - like DNA fragments , which were subsequently used as nifV - and leuA - specific probes , respectively , to clone XbaI fragments of 2 . 1 kbp ( pOST4 ) and 2 . 6 kbp ( pOST2 ) .", + "entities": [ + "nifV - like DNA fragments", + "nifV", + "leuA - specific probes", + "XbaI fragments" + ] + }, + { + "id": "11353", + "type": "gene", + "text": "Present results reveal a frequency - dependent inhibition of ganglionic transmission by diltiazem , and suggest that diltiazem may depress excessive sympathetic activity without affecting normal ganglionic transmission .", + "entities": [] + }, + { + "id": "11354", + "type": "gene", + "text": "The Sox gene family ( Sry like HMG box gene ) is characterised by a conserved DNA sequence encoding a domain of approximately 80 amino acids which is responsible for sequence specific DNA binding .", + "entities": [ + "Sox gene family", + "Sry like HMG box gene" + ] + }, + { + "id": "11355", + "type": "gene", + "text": "We used oligonucleotide - directed mutagenesis to alter a site in MucA homologous to the Ala - Gly cleavage site of LexA .", + "entities": [ + "MucA", + "LexA" + ] + }, + { + "id": "11356", + "type": "gene", + "text": "The calculated pD2 values were 8 . 8 for E , 8 . 6 for DHE and 6 . 6 for M .", + "entities": [] + }, + { + "id": "11357", + "type": "gene", + "text": "The results imply that kindling does not produce its facilitating effect on acquisition of HPC SS by removing a disruptive effect of the stimulation .", + "entities": [] + }, + { + "id": "11358", + "type": "gene", + "text": "The serum concentration of iP before dialysis ( HD ) was on average 3 . 06 ( + / - 0 . 81 ) mmol / l and D was on average 55 . 6 ( + / - 10 . 0 ) mmol .", + "entities": [] + }, + { + "id": "11359", + "type": "gene", + "text": "Furthermore , in the ischemia / angiotension II - induced AHF model , NIC decreased left ventricular end - diastolic pressure ( LVEDP ) .", + "entities": [ + "angiotension II" + ] + }, + { + "id": "11360", + "type": "gene", + "text": "For functional studies , two promoter regions were cloned upstream of the reporter gene , chloramphenicol acetyl transferase ( CAT ) : ( i ) phbetaE - B - the plasmid that contains the human ( h ) promoter region ( - 2832 to + 101 ) including URE , and ( ii ) prhbetaE - B - the plasmid that contains the rhesus ( rh ) promoter region excluding URE as it lacks a 270 bp region of the hbetaAPP promoter ( - 2435 to - 2165 ) .", + "entities": [ + "chloramphenicol acetyl transferase", + "CAT", + "hbetaAPP promoter" + ] + }, + { + "id": "11361", + "type": "gene", + "text": "Here , a case of Sjogren ' s syndrome is presented that was initially diagnosed because of dental complaints , and long - term treatment of Sjogren ' s patients is discussed .", + "entities": [] + }, + { + "id": "11362", + "type": "gene", + "text": "Magnetic storm indicators could be used in medicine , in geophysics and for special purposes .", + "entities": [] + }, + { + "id": "11363", + "type": "gene", + "text": "Short therapy with omeprazole 20 mg / b . i . d . , clarithromycin 500 mg / b . i . d . , and CBS 120 mg / q . i . d .", + "entities": [] + }, + { + "id": "11364", + "type": "gene", + "text": "is a safe , well tolerated combination that achieves a 80 . 6 % eradication rate of H . pylori and duodenal ulcer healing rates as good as those achieved by omeprazole 20 mg / d when given for 4 wk .", + "entities": [] + }, + { + "id": "11365", + "type": "gene", + "text": "Effects of alcoholism on the family", + "entities": [] + }, + { + "id": "11366", + "type": "gene", + "text": "Samples obtained from normal volunteers and from the great majority of the patients , excluding those with asthma , had no effect on ciliary beating .", + "entities": [] + }, + { + "id": "11367", + "type": "gene", + "text": "Action of strontium - 90 and metaphos on Cyprinus carpio", + "entities": [] + }, + { + "id": "11368", + "type": "gene", + "text": "Like the p190 - B exon , the first exon of p190 - A is extremely large ( 3 . 7 kb in length ) , encoding both the GTPase and middle domains ( residues 1 - 1228 ) , but not the remaining GAP domain , suggesting a high conservation of genomic structure between two p190 genes .", + "entities": [ + "p190 - B", + "p190 - A", + "GTPase", + "GAP domain", + "p190 genes" + ] + }, + { + "id": "11369", + "type": "gene", + "text": "These genes encode a tryptophanyl tRNA , the protein translocase component SecE , the antiterminator protein NusG , and the ribosomal proteins L11 and L1 in addition to PkwR , a putative regulatory protein of the LacI - GalR family .", + "entities": [ + "tryptophanyl tRNA", + "protein translocase", + "SecE", + "antiterminator protein NusG", + "L11", + "L1", + "PkwR", + "LacI", + "GalR" + ] + }, + { + "id": "11370", + "type": "gene", + "text": "I .", + "entities": [] + }, + { + "id": "11371", + "type": "gene", + "text": "Cardiovascular risk factors were measured by standardized techniques .", + "entities": [] + }, + { + "id": "11372", + "type": "gene", + "text": "Electroglottography is a useful , non - invasive technique that can assist in the assessment of vocal fold dysfunction .", + "entities": [] + }, + { + "id": "11373", + "type": "gene", + "text": "VEGF promoter activity in transient transfections was decreased by either pharmacological or genetic inhibition of EGFR , Ras , or phosphatidylinositol 3 ' - kinase [ PI ( 3 ) kinase ] .", + "entities": [ + "VEGF promoter", + "EGFR", + "Ras", + "[ PI ( 3 ) kinase ]" + ] + }, + { + "id": "11374", + "type": "gene", + "text": "We have also identified a functional domain in the ORF 50 protein , an immediate - early gene product that is mainly encoded by ORF 50 .", + "entities": [ + "immediate - early gene product" + ] + }, + { + "id": "11375", + "type": "gene", + "text": "In vitro protein retention experiments in which Hsp90 heterocomplexes were precipitated resulted in coprecipitation of Cns1 .", + "entities": [ + "Hsp90 heterocomplexes", + "Cns1" + ] + }, + { + "id": "11376", + "type": "gene", + "text": "Only one gene , fibronectin ( FN ) , was highly overexpressed ( > 60 - fold ) in LNCaP - r cells , consistent with previously reported overexpression of FN in prostate cancer .", + "entities": [ + "fibronectin", + "FN", + "FN" + ] + }, + { + "id": "11377", + "type": "gene", + "text": "Immunologic mechanisms in chronic brucellosis in humans .", + "entities": [] + }, + { + "id": "11378", + "type": "gene", + "text": "The measurement of NO in biological systems using chemiluminescence .", + "entities": [] + }, + { + "id": "11379", + "type": "gene", + "text": "Laboratory exam : IDR of the tuberculin was high positive , chest radiography shows hilar bilateral calcifications , ORL exam shows a tumor at the foot of the epiglottis and anatomopathological exam shows low differentiated epidermoid carcinoma .", + "entities": [ + "tuberculin" + ] + }, + { + "id": "11380", + "type": "gene", + "text": "Recombination and transcription of the endogenous Ig heavy chain locus is effected by the Ig heavy chain intronic enhancer core region in the absence of the matrix attachment regions .", + "entities": [ + "endogenous Ig heavy chain locus", + "Ig heavy chain intronic enhancer core region" + ] + }, + { + "id": "11381", + "type": "gene", + "text": "The present study shows that phosphatidylinositol 3 - kinase - dependent p38 kinase activation regulates Akt phosphorylation and activity in human neutrophils .", + "entities": [ + "phosphatidylinositol 3 - kinase", + "p38 kinase", + "Akt" + ] + }, + { + "id": "11382", + "type": "gene", + "text": "Chromatin repression of these replacement genes would be avoided , consistent with the high , constitutive expression of replacement H3 histone genes in plants .", + "entities": [ + "H3 histone genes" + ] + }, + { + "id": "11383", + "type": "gene", + "text": "Diethylene benzene", + "entities": [] + }, + { + "id": "11384", + "type": "gene", + "text": "Recent studies have suggested that Y319 also positively regulate ZAP - 70 function .", + "entities": [ + "ZAP - 70" + ] + }, + { + "id": "11385", + "type": "gene", + "text": "Pathophysiology of bone loss in castrated animals .", + "entities": [] + }, + { + "id": "11386", + "type": "gene", + "text": "Complexes of qTBP42 with each complementary strand of telomeric DNA and with quadruplex forms of the guanine - rich strand had 3 . 7 - 14 . 6 nM dissociation constants , Kd , whereas complexes with double - stranded telomeric DNA had up to 100 - fold higher Kd values .", + "entities": [ + "qTBP42" + ] + }, + { + "id": "11387", + "type": "gene", + "text": "Fifty - four patients were divided into groups according to their clinical presentation ; seven asymptomatic volunteers , 20 patients with duodenal - gastric reflux gastropathy ( DRG ) , 16 patients with recurrent ulcers of the duodenal bulb ( RUD ) , and 11 patients with Moynihan ' s disease .", + "entities": [] + }, + { + "id": "11388", + "type": "gene", + "text": "Proceedings : Barrels and somatotopy in S I neocortex of the brush - tailed possum .", + "entities": [] + }, + { + "id": "11389", + "type": "gene", + "text": "Variability within Down ' s syndrome ( trisomy - 21 ) : empirically observed sex differences in IQs .", + "entities": [] + }, + { + "id": "11390", + "type": "gene", + "text": "We are reporting an autopsy case of so - called \" acute multiple sclerosis \" that was difficult to differentiate from a brain tumor on MRI findings .", + "entities": [] + }, + { + "id": "11391", + "type": "gene", + "text": "The early lethality of the left - sided resectio was 0 % and the postoperative survival - - 5 - 10 months .", + "entities": [] + }, + { + "id": "11392", + "type": "gene", + "text": "ORF E8 colinear with ORF E6 , which could generate a 50 - amino - acid protein with a hydrophobic segment , did not transform cells when cloned into the pZipNeo vector .", + "entities": [ + "ORF E8", + "ORF E6" + ] + }, + { + "id": "11393", + "type": "gene", + "text": "When the cervical Pap smear is positive .", + "entities": [] + }, + { + "id": "11394", + "type": "gene", + "text": "However , the inability to export RNA from the nucleus to the cytoplasm was not limited to a particular phase of the cell division cycle .", + "entities": [] + }, + { + "id": "11395", + "type": "gene", + "text": "The mechanism of ligand - activated estrogen receptor alpha ( ERalpha ) - dependent activation of gene expression through the SRE was determined by mutational analysis of the promoter , analysis of mitogen - activated protein kinase ( MAPK ) pathway activation by E2 , and transforming growth factor alpha ( TGF - alpha ) as a positive control .", + "entities": [ + "estrogen receptor alpha", + "ERalpha", + "mitogen - activated protein kinase", + "MAPK", + "transforming growth factor alpha", + "TGF - alpha" + ] + }, + { + "id": "11396", + "type": "gene", + "text": "The results were as follows : 1 ) Total integrated EMG activity of FB group was approximately equal in any occluded position , whereas that of CG and GF group varied from position to position .", + "entities": [] + }, + { + "id": "11397", + "type": "gene", + "text": "For the first group , the maximal decrease in plasma potassium elicited by salbutamol was 0 . 80 + / - 0 . 19 , 0 . 48 + / - 0 . 22 , and 0 . 78 + / - 0 . 46 mmol / l , and for the second group , maximal decrement was 1 . 31 + / - 0 . 37 , 0 . 70 + / - 0 . 24 , and 0 . 84 + / - 0 . 17 mmol / l for the iv , po , and it routes , respectively .", + "entities": [] + }, + { + "id": "11398", + "type": "gene", + "text": "Plasma lactoferrin and the blood count of polynuclear neutrophils", + "entities": [ + "Plasma lactoferrin" + ] + }, + { + "id": "11399", + "type": "gene", + "text": "These results indicate that the sulfhydryl group of certain angiotensin converting enzyme inhibitors can potentiate their effect on the endogenous nitrovasodilator EDRF .", + "entities": [ + "angiotensin converting enzyme", + "EDRF" + ] + }, + { + "id": "11400", + "type": "gene", + "text": "Disruption of the chromosomal AAR1 gene in alpha and a / alpha cells conferred the nonmating phenotype , and the a / alpha diploids could not sporulate .", + "entities": [ + "chromosomal AAR1 gene" + ] + }, + { + "id": "11401", + "type": "gene", + "text": "Nevertheless , they are functionally distinct in that FcalphaRI binds human IgA ( hIgA ) but not bovine IgG2 ( bIgG2 ) , whereas bFcgamma2R binds bIgG2 but not hIgA .", + "entities": [ + "FcalphaRI", + "human IgA", + "hIgA", + "bovine IgG2", + "bIgG2", + "bFcgamma2R", + "bIgG2", + "hIgA" + ] + }, + { + "id": "11402", + "type": "gene", + "text": "Both mutations completely abolished binding of the Abl SH3 domain to proline - rich target proteins in a filter - binding assay .", + "entities": [ + "SH3" + ] + }, + { + "id": "11403", + "type": "gene", + "text": "BACKGROUND : Left ventricular hypertrophy is a heterogeneous disorder with distinct morphologies .", + "entities": [] + }, + { + "id": "11404", + "type": "gene", + "text": "However , study of the productive gamma gene showed that the skipped variable exon was bounded by normal splicing signals and that the adjacent intron organization was not altered .", + "entities": [] + }, + { + "id": "11405", + "type": "gene", + "text": "Intravenous amine pressor tests in healthy volunteers .", + "entities": [] + }, + { + "id": "11406", + "type": "gene", + "text": "The colony - stimulating factors ( CSFs ) principally involved in the production of neutrophils and monocytes are granulocyte CSF , granulocyte - macrophage CSF , macrophage CSF , and interleukin 3 ( sometimes called multi - CSF ) .", + "entities": [ + "colony - stimulating factors", + "CSFs", + "granulocyte CSF", + "granulocyte - macrophage CSF", + "macrophage CSF", + "interleukin 3", + "multi - CSF" + ] + }, + { + "id": "11407", + "type": "gene", + "text": "Expression of the phenylalanine hydroxylase gene in livers and kidneys of rodents is activated at birth and is induced by glucocorticoids and cyclic AMP in the liver .", + "entities": [ + "phenylalanine hydroxylase gene" + ] + }, + { + "id": "11408", + "type": "gene", + "text": "The best endometrial ablation was seen when SnET2 was given by intrauterine administration with light treatment at 150 J / cm 24 hours later .", + "entities": [] + }, + { + "id": "11409", + "type": "gene", + "text": "Here we report the cloning , expression , and biochemical characterization of the 32 - kDa subunit of human ( h ) TFIID , termed hTAFII32 .", + "entities": [ + "TFIID", + "hTAFII32" + ] + }, + { + "id": "11410", + "type": "gene", + "text": "Factors associated with intrafamilial transmission of hepatitis B virus infection in Korea .", + "entities": [] + }, + { + "id": "11411", + "type": "gene", + "text": "Purification and cloning of a novel serine protease , RNK - Met - 1 , from the granules of a rat natural killer cell leukemia .", + "entities": [ + "serine protease", + "RNK - Met - 1" + ] + }, + { + "id": "11412", + "type": "gene", + "text": "Polysome analyses in a temperature - sensitive fal1 - 1 mutant and a Fal1p - depleted strain reveal a decrease in the number of 40S ribosomal subunits .", + "entities": [ + "fal1 - 1 mutant", + "Fal1p", + "40S ribosomal subunits" + ] + }, + { + "id": "11413", + "type": "gene", + "text": "S . , and Walter , P .", + "entities": [] + }, + { + "id": "11414", + "type": "gene", + "text": "The multiple functions of Pmt3p described here suggest that several nuclear proteins are regulated by Pmt3p conjugation .", + "entities": [ + "Pmt3p", + "Pmt3p" + ] + }, + { + "id": "11415", + "type": "gene", + "text": "Mutations within the C terminus of c - fos at serine residues that are phosphorylation targets for growth factors and MAP kinase completely abrogate transactivation and block potentiation by MAP kinase .", + "entities": [ + "c - fos", + "MAP kinase", + "MAP kinase" + ] + }, + { + "id": "11416", + "type": "gene", + "text": "Transcriptional regulators utilizing the POU domain DNA - binding motif have been shown to form multi - protein complexes dependent on the POU domain itself and its flexible recognition of various octamer sequence elements .", + "entities": [ + "POU domain DNA - binding motif", + "POU domain" + ] + }, + { + "id": "11417", + "type": "gene", + "text": "Against gram - positive organisms , E - 4767 and E - 5065 were , in general , eight - and fourfold more active than tosufloxacin , which is the most potent of the reference compounds .", + "entities": [] + }, + { + "id": "11418", + "type": "gene", + "text": "The ORF 4 gene was minimally active , whereas the ORF 62 gene gave twofold induction ; both genes , acting together , gave fivefold induction .", + "entities": [] + }, + { + "id": "11419", + "type": "gene", + "text": "Thrombolysis was followed by a similar increase of platelet activity with maximal values reached at the 3rd hour in both groups ( 196 + / - 43 IU / ml in Group 1 and 192 + / - 39 in Group 2 : p & lt ; 001versus baseline and p NS between the groups ) .", + "entities": [] + }, + { + "id": "11420", + "type": "gene", + "text": "Rigorous treatment protocols for diet delivery and EEN - related GI adverse effects were applied .", + "entities": [] + }, + { + "id": "11421", + "type": "gene", + "text": "In addition , an mck1 mds1 mrk1 triple disruptant was viable .", + "entities": [ + "mrk1" + ] + }, + { + "id": "11422", + "type": "gene", + "text": "Employing this sequence information from c11 / 1 , the c11 / 1 - specific cDNA was generated from poly ( A ) + RNA of bovine PMNLs by reverse transcription and a combination of polymerase chain reaction ( PCR ) methods .", + "entities": [] + }, + { + "id": "11423", + "type": "gene", + "text": "Relationship between mitochondrial NADH - ubiquinone reductase and a bacterial NAD - reducing hydrogenase .", + "entities": [ + "mitochondrial NADH - ubiquinone reductase", + "bacterial NAD - reducing hydrogenase" + ] + }, + { + "id": "11424", + "type": "gene", + "text": "The effect of ibopamine and furosemide in 130 patients with NYHA Class I and II heart failure were studied in a parallel , double - blind , randomized placebo - controlled multi - centre trial .", + "entities": [] + }, + { + "id": "11425", + "type": "gene", + "text": "The transcription factor AP - 2 is encoded by a gene located on chromosome 6 near the HLA locus .", + "entities": [ + "transcription factor AP - 2", + "HLA locus" + ] + }, + { + "id": "11426", + "type": "gene", + "text": "After 28 days of haloperidol treatment , similar changes were observed for delta , together with an increase of alpha 1 , and a decrease of fast beta .", + "entities": [] + }, + { + "id": "11427", + "type": "gene", + "text": "Furthermore , this study looks at the impact of synthesis conditions on block length and crystallinity , and the impact of the blocking on both , crystallinity and solubility of the polymers .", + "entities": [] + }, + { + "id": "11428", + "type": "gene", + "text": "Scintigraphic visualisation of Walker carcinoma - 256 in Sprague - Dawley rats by means of 99mTc - labelled monocytes .", + "entities": [] + }, + { + "id": "11429", + "type": "gene", + "text": "Laboratory pyrolyses have indeed shown that PCBs give significant yields of PCDFs , and chlorobenzenes give both PCDFs and PCDDs .", + "entities": [] + }, + { + "id": "11430", + "type": "gene", + "text": "Concordantly , it was shown that the dnHLH protein Id1 inhibits differentiation of muscle and myeloid cells in vitro .", + "entities": [ + "Id1" + ] + }, + { + "id": "11431", + "type": "gene", + "text": "Protein splicing : evidence for an N - O acyl rearrangement as the initial step in the splicing process .", + "entities": [] + }, + { + "id": "11432", + "type": "gene", + "text": "Assays of total cholesterol as well as the HDL , HDL2 , LDL , triglycerides , endothelin - 1 , lipoprotein ( a ) , estradiol and FSH were also obtained at baseline before receiving ERT and after 3 months of ERT .", + "entities": [ + "HDL", + "HDL2", + "LDL", + "endothelin - 1", + "lipoprotein ( a )", + "FSH" + ] + }, + { + "id": "11433", + "type": "gene", + "text": "A possible decrease in theophylline ' s volume of distribution at 4 days , but not immediately , after administration of chloroquine was suggested , although this just failed to achieve statistical significance ( p = 0 . 055 ) .", + "entities": [] + }, + { + "id": "11434", + "type": "gene", + "text": "Effect of indomethacin and prostaglandin F2 alpha on parturition in swine .", + "entities": [] + }, + { + "id": "11435", + "type": "gene", + "text": "BACKGROUND : Dermoscopy is a noninvasive technique that increases the diagnostic accuracy of pigmented skin lesions , particularly improving the diagnosis of patients with cutaneous melanoma in situ ( CMIS ) and early invasive melanoma .", + "entities": [] + }, + { + "id": "11436", + "type": "gene", + "text": "Lipid concentration and lipase activity in the epiphysis of adrenalectomized rats consuming food with different sodium content", + "entities": [ + "lipase" + ] + }, + { + "id": "11437", + "type": "gene", + "text": "Prostaglandin synthesis inhibitors have been shown to delay healing of bone and this has led to limitations on their use clinically in some situations .", + "entities": [] + }, + { + "id": "11438", + "type": "gene", + "text": "CONCLUSIONS : Serum levels of S - 100beta are reliable markers for adverse neurologic outcomes after cardiac surgery .", + "entities": [ + "S - 100beta" + ] + }, + { + "id": "11439", + "type": "gene", + "text": "Using lectin - affinity chromatography , discordance between the pattern of O - glycosylation of SSBP and DSBP was demonstrated .", + "entities": [ + "lectin", + "SSBP", + "DSBP" + ] + }, + { + "id": "11440", + "type": "gene", + "text": "Pretreatment of cells or mouse skin with antisense oligonucleotides of PKCzeta impaired UV - induced activation of AP - 1 in JB6 cells as well as in AP - 1 - luciferase transgenic mice .", + "entities": [ + "PKCzeta", + "AP - 1", + "AP - 1", + "luciferase" + ] + }, + { + "id": "11441", + "type": "gene", + "text": "The expression of chloramphenicol acetyltransferase was detected within 1 h after infection of cells with recombinant virus , reflecting the early nature of the promoters used .", + "entities": [ + "chloramphenicol acetyltransferase" + ] + }, + { + "id": "11442", + "type": "gene", + "text": "Specifically , the deduced FR - 19 amino acid sequence has approximately89 , 77 , and 68 % overall identity to chicken TEF - 1A , mouse TEF - 1 , and mouse embryonic TEA domain - containing factor , respectively .", + "entities": [ + "FR - 19 amino acid sequence", + "chicken TEF - 1A", + "mouse TEF - 1", + "mouse embryonic TEA domain - containing factor" + ] + }, + { + "id": "11443", + "type": "gene", + "text": "Doppler echo in evaluating arteriovenous fistulae for dialysis", + "entities": [] + }, + { + "id": "11444", + "type": "gene", + "text": "Cloning by complementation and subsequent physical and genetic analysis revealed that it maps to RAF1 .", + "entities": [ + "RAF1" + ] + }, + { + "id": "11445", + "type": "gene", + "text": "Genetic and biochemical evidence suggests that v - Crk can induce transformation of chicken embryo fibroblasts by influencing the activity of cellular proteins involved in growth regulation .", + "entities": [ + "v - Crk" + ] + }, + { + "id": "11446", + "type": "gene", + "text": "The gene encoding the 105 - kDa protein ( p105 ) precursor of the p50 subunit of transcription factor NF - kappa B also encodes a p70 I kappa B protein , I kappa B gamma , which is identical to the C - terminal 607 amino acids of p105 .", + "entities": [ + "105 - kDa protein ( p105 ) precursor", + "p50 subunit", + "NF - kappa B", + "p70 I kappa B protein", + "I kappa B gamma", + "p105" + ] + }, + { + "id": "11447", + "type": "gene", + "text": "STUDY DESIGN .", + "entities": [] + }, + { + "id": "11448", + "type": "gene", + "text": "In vitro translation of RNA synthesized from the cloned cDNAs predicts that P0 transcripts are translated into a novel 12 . 5 - kilodalton protein corresponding to the first open reading frame .", + "entities": [ + "P0 transcripts" + ] + }, + { + "id": "11449", + "type": "gene", + "text": "Currents aspects of H2 receptor antagonists in the treatment of ulcers", + "entities": [ + "H2 receptor" + ] + }, + { + "id": "11450", + "type": "gene", + "text": "On the basis of the mechanism of action , two groups of inodilators are distinguished , the phosphodiesterase inhibitors and the dopaminergic agents .", + "entities": [] + }, + { + "id": "11451", + "type": "gene", + "text": "There was no clear correlation between the MFA and the severity of the UTS phenotype .", + "entities": [] + }, + { + "id": "11452", + "type": "gene", + "text": "The encoded sequence revealed a typical signal peptide , a predominantly hydrophilic 707 amino acid residue domain with 8 N - glycosylation sites , a transmembrane domain , and a C - terminal domain of 52 amino acids .", + "entities": [] + }, + { + "id": "11453", + "type": "gene", + "text": "Levels of both PGF and PGFM were significantly higher during early spontaneous labour , at a cervical dilatation of less than 4 cm , than before the onset of labour .", + "entities": [] + }, + { + "id": "11454", + "type": "gene", + "text": "The Stat5b mRNA has a size of 5 . 6 kb and encodes a protein of 786 amino acids .", + "entities": [ + "Stat5b mRNA" + ] + }, + { + "id": "11455", + "type": "gene", + "text": "These regions overlap with the HIT protein similarity regions .", + "entities": [ + "HIT protein similarity regions" + ] + }, + { + "id": "11456", + "type": "gene", + "text": "BACKGROUND : The aim of this study was to determine the response rates and toxicity of two regimens containing granulocyte - macrophage - colony stimulating factor ( GM - CSF ) in combination with interleukin - 2 ( IL - 2 ) in the treatment of patients with metastatic renal cell carcinoma .", + "entities": [ + "granulocyte - macrophage - colony stimulating factor", + "GM - CSF", + "interleukin - 2", + "IL - 2" + ] + }, + { + "id": "11457", + "type": "gene", + "text": "All of the elements exhibited a uniform structure .", + "entities": [] + }, + { + "id": "11458", + "type": "gene", + "text": "Analysis of corticosteroids .", + "entities": [] + }, + { + "id": "11459", + "type": "gene", + "text": "NH3 and NO interaction with Si ( 100 ) - ( 2 x 1 ) surfaces .", + "entities": [] + }, + { + "id": "11460", + "type": "gene", + "text": "Triumph of Leninist national policy", + "entities": [] + }, + { + "id": "11461", + "type": "gene", + "text": "At the time of the blind therapeutic doses , Tg - off values ranged from 8 to 608 microg / l .", + "entities": [ + "Tg" + ] + }, + { + "id": "11462", + "type": "gene", + "text": "Sex of calf ( variate 2 ) was associated most closely with width of muzzle and head .", + "entities": [] + }, + { + "id": "11463", + "type": "gene", + "text": "A single exon encodes the carboxyl - terminal 26 amino acids of the ssd chain and the 3 ' untranslated region of its mRNA , ending with a poly ( A ) - addition site .", + "entities": [ + "ssd chain" + ] + }, + { + "id": "11464", + "type": "gene", + "text": "Furthermore , loss of methylation also greatly reduced the association of another yeast B - type subunit , Rts1p .", + "entities": [ + "Rts1p" + ] + }, + { + "id": "11465", + "type": "gene", + "text": "These results suggested that BACH1t recruits BACH1 to the nucleus through BTB domain - mediated interaction .", + "entities": [ + "BACH1t", + "BACH1", + "BTB" + ] + }, + { + "id": "11466", + "type": "gene", + "text": "We describe a novel method using Saccharomyces cerevisiae for detecting protein - truncating mutations in any gene of interest .", + "entities": [] + }, + { + "id": "11467", + "type": "gene", + "text": "Hydrogels for tissue engineering .", + "entities": [] + }, + { + "id": "11468", + "type": "gene", + "text": "The COL7A1 gene , which encodes type VII collagen , has been implicated as a candidate gene for dominantly and recessively inherited forms of dystrophic epidermolysis bullosa .", + "entities": [ + "COL7A1 gene", + "type VII collagen" + ] + }, + { + "id": "11469", + "type": "gene", + "text": "Thus , in the presence of active S - CDKs and Dbf4 / Cdc7 , Mcms may open origins and thereby facilitate the loading of RPA .", + "entities": [ + "active S - CDKs", + "Dbf4", + "Cdc7", + "Mcms", + "RPA" + ] + }, + { + "id": "11470", + "type": "gene", + "text": "Antibodies to the human PTS1R recognize this protein in human , monkey , rat , and hamster cells .", + "entities": [ + "human PTS1R" + ] + }, + { + "id": "11471", + "type": "gene", + "text": "Immunohistochemical studies revealed positive staining for S100 protein in all the granular cell tumors of the adult but in none of the congenital granular cell epulides .", + "entities": [ + "S100 protein" + ] + }, + { + "id": "11472", + "type": "gene", + "text": "In supine position , plasma ANP levels ranged from 12 pg / ml to 51 . 5 pg / ml , with an average level of 35 . 3 + / - 11 . 5 pg / ml .", + "entities": [ + "ANP" + ] + }, + { + "id": "11473", + "type": "gene", + "text": "DNA sequencing of a 17 - kb segment encompassing a gammaherpesvirus divergent locus ( DL - B ) between ORF11 and ORF17 revealed the presence of nine viral ORFs with predicted gene products related to cellular proteins .", + "entities": [] + }, + { + "id": "11474", + "type": "gene", + "text": "This is a challenging task insofar as direct measures of ISF glucose are not readily available .", + "entities": [] + }, + { + "id": "11475", + "type": "gene", + "text": "The PEPCK promoter fragment was introduced either in the proper orientation for transcription of the TK gene or in the opposite orientation .", + "entities": [ + "PEPCK", + "TK gene" + ] + }, + { + "id": "11476", + "type": "gene", + "text": "The mean duration of pain relief was 4 - 6 weeks .", + "entities": [] + }, + { + "id": "11477", + "type": "gene", + "text": "The role of negative regulators such as NCE3 , as well as the previously described SIN5 gene , in determining the promoter specificity of homologous activators is discussed .", + "entities": [ + "NCE3", + "SIN5 gene" + ] + }, + { + "id": "11478", + "type": "gene", + "text": "PURPOSE : The aim of this study was to evaluate the bony anchorage of a new implant ( orderly wired surface effect with alloy Ti Al Va and ordered pores of 488 mu ) .", + "entities": [] + }, + { + "id": "11479", + "type": "gene", + "text": "The distribution of patients was as follows : group 1 - - complex gamma - therapy ( 55 cases ) , group 2 - - complex gamma - therapy plus iliac lymphadenectomy ( 50 cases ) and group 3 - - complex radiation treatment with megavolt bremsstrahlung beam from the luc type installation and iliac lymphadenectomy ( 50 cases ) .", + "entities": [] + }, + { + "id": "11480", + "type": "gene", + "text": "Chem .", + "entities": [] + }, + { + "id": "11481", + "type": "gene", + "text": "The Wnt signaling pathway functions reiteratively during animal development to control cell fate decisions .", + "entities": [ + "Wnt" + ] + }, + { + "id": "11482", + "type": "gene", + "text": "Similarly , the sequence of the U2 RNA region shown to be involved in pre - mRNA branchpoint recognition in yeast , and exactly conserved in metazoan U2 RNAs , was totally divergent in trypanosomes .", + "entities": [ + "U2 RNA region", + "metazoan U2 RNAs" + ] + }, + { + "id": "11483", + "type": "gene", + "text": "Value of urine glucose tests in the management of type II diabetes mellitus .", + "entities": [] + }, + { + "id": "11484", + "type": "gene", + "text": "The SH2 domain - containing inositol 5 ' - phosphatase ( SHIP ) recruits the p85 subunit of phosphoinositide 3 - kinase during FcgammaRIIb1 - mediated inhibition of B cell receptor signaling .", + "entities": [ + "SH2 domain - containing inositol 5 ' - phosphatase", + "SHIP", + "p85 subunit", + "phosphoinositide 3 - kinase", + "FcgammaRIIb1", + "B cell receptor" + ] + }, + { + "id": "11485", + "type": "gene", + "text": "Thus , IHHNV is closely related to densoviruses of the genus Brevidensovirus in the family Parvoviridae , and we therefore propose to rename this virus Penaeus stylirostris densovirus ( PstDNV ) .", + "entities": [] + }, + { + "id": "11486", + "type": "gene", + "text": "These results indicate that HIV - 1 Gag sequences can influence the viral PR - mediated processing of the MuLV TM Env protein p15 ( E ) .", + "entities": [ + "Gag sequences", + "viral PR", + "p15 ( E )" + ] + }, + { + "id": "11487", + "type": "gene", + "text": "Lipid hydroperoxide levels in plasma and LDL remained unchanged throughout the study .", + "entities": [ + "LDL" + ] + }, + { + "id": "11488", + "type": "gene", + "text": "These consisted of beading and strictures mainly of the intrahepatic biliary tree ( IHB ) .", + "entities": [] + }, + { + "id": "11489", + "type": "gene", + "text": "Removal of PDMP from the cell medium resulted in reversal of the cell cycle changes , with cells re - entering the S phase .", + "entities": [] + }, + { + "id": "11490", + "type": "gene", + "text": "Nucleotide sequence and transcriptional analysis of the DNA polymerase gene of Bombyx mori nuclear polyhedrosis virus .", + "entities": [ + "DNA polymerase gene of Bombyx mori nuclear polyhedrosis virus" + ] + }, + { + "id": "11491", + "type": "gene", + "text": "157 + / - 16 mg / dl ; NS ) , glucose levels , and basal ( 17 + / - 4 vs .", + "entities": [] + }, + { + "id": "11492", + "type": "gene", + "text": "Effects of aging and beta - adrenergic - blockade on standing - induced QT / QS2 changes .", + "entities": [] + }, + { + "id": "11493", + "type": "gene", + "text": "Furthermore , the potency of Dacarbacine in the treatment of carcinoid tumors seems to be underestimated up to now .", + "entities": [] + }, + { + "id": "11494", + "type": "gene", + "text": "Stat activation in response to GH and IL - 6 was determined by reporter gene induction .", + "entities": [ + "Stat", + "GH", + "IL - 6" + ] + }, + { + "id": "11495", + "type": "gene", + "text": "The hybridizing clone of V . vulnificus chromosomal DNA complemented a V . cholerae fur mutant .", + "entities": [ + "V . cholerae fur mutant" + ] + }, + { + "id": "11496", + "type": "gene", + "text": "Identification of this region as the E . coli tmk gene was confirmed by functional complementation of a yeast dTMP kinase temperature - sensitive mutant and by in vitro enzyme assay of the thymidylate kinase activity in cell extracts of E . coli by use of tmk - overproducing plasmids .", + "entities": [ + "E . coli tmk gene", + "yeast dTMP kinase", + "thymidylate kinase", + "tmk" + ] + }, + { + "id": "11497", + "type": "gene", + "text": "Sequence comparison of the 0 . 38 kb promoter sequence with the promoters of the Sm - E gene and U1 snRNA genes revealed several homologous motifs , suggesting that genes encoding the snRNP components may be coordinately regulated .", + "entities": [ + "Sm - E", + "U1 snRNA genes" + ] + }, + { + "id": "11498", + "type": "gene", + "text": "Foreign profiles in air pollution control activities .", + "entities": [] + }, + { + "id": "11499", + "type": "gene", + "text": "A new method for the in vitro transfer of delayed hypersensitivity by dialysed transfer factor .", + "entities": [ + "transfer factor" + ] + }, + { + "id": "11500", + "type": "gene", + "text": "Chronic thyroiditis as a risk factor of B - cell lymphoma in the thyroid gland .", + "entities": [] + }, + { + "id": "11501", + "type": "gene", + "text": "Histamine reactivity had returned to normal in half the workers who had left their original factories , but in only one worker who had moved within her original factory .", + "entities": [] + }, + { + "id": "11502", + "type": "gene", + "text": "Abdominal tumors in childhood .", + "entities": [] + }, + { + "id": "11503", + "type": "gene", + "text": "The authors present the only two studies that have proved successful in treating animal models of osteoarthritis using gene therapy , and propose an overview of several strategies for the development of gene therapy in osteoarthritis treatment in the future .", + "entities": [] + }, + { + "id": "11504", + "type": "gene", + "text": "The 87K protein , together with proteins of 105 , 000 and 75 , 000 daltons , are translated from leftward transcribed ( 1 - strand ) messenger RNAs that are complementary to the viral genome between positions 11 . 2 and 31 . 5 .", + "entities": [] + }, + { + "id": "11505", + "type": "gene", + "text": "Monkeys were evaluated before and after unilateral and serial bilateral removal of superior temporal cortex .", + "entities": [] + }, + { + "id": "11506", + "type": "gene", + "text": "The ORF1 protein was found to be highly homologous to the putative potexvirus RNA replicases ; ORF2 , - 3 , - 5 and - 6 proteins also have analogues among the potex - and / or carlavirus - encoded proteins .", + "entities": [ + "potexvirus RNA replicases" + ] + }, + { + "id": "11507", + "type": "gene", + "text": "Eukaryotic translation initiation factor 4GI is a cellular target for NS1 protein , a translational activator of influenza virus .", + "entities": [ + "Eukaryotic translation initiation factor 4GI", + "NS1 protein" + ] + }, + { + "id": "11508", + "type": "gene", + "text": "We show that Rlm1 and Smp1 have MEF2 - related DNA - binding specificities : Rlm1 binds with the same specificity as MEF2 , CTA ( T / A ) 4TAG , while SMP1 binds a more extended consensus sequence , ACTACTA ( T / A ) 4TAG .", + "entities": [ + "Rlm1", + "Smp1", + "MEF2", + "Rlm1", + "MEF2", + "CTA ( T / A ) 4TAG", + "SMP1" + ] + }, + { + "id": "11509", + "type": "gene", + "text": "Repetitive sequences are present in at least three introns of the cytochrome P - 450PBc2 gene , but not in exons or the 5 ' - flanking region .", + "entities": [ + "cytochrome P - 450PBc2 gene" + ] + }, + { + "id": "11510", + "type": "gene", + "text": "The incidence of hepatitis B antigen following transfusion was about 2 . 8 per cent .", + "entities": [ + "hepatitis B antigen" + ] + }, + { + "id": "11511", + "type": "gene", + "text": "Plasma vitamin E , total lipids and myeloperoxidase levels during spinal surgery .", + "entities": [ + "myeloperoxidase" + ] + }, + { + "id": "11512", + "type": "gene", + "text": "Finally , the C - terminal region of ENBP1 shows strong homology to a protein from rat that is specifically expressed in testis tissue .", + "entities": [ + "ENBP1" + ] + }, + { + "id": "11513", + "type": "gene", + "text": "The action of nef was specific to the LTR , as expression of nef had no effect on the activity of the simian virus 40 , c - fms , urokinase plasminogen activator , or type 5 acid phosphatase promoter . trans - activating activity was also manifested by a frameshift mutant expressing only the first 35 amino acids of the protein .", + "entities": [ + "nef", + "nef", + "c - fms", + "urokinase plasminogen activator", + "type 5 acid phosphatase promoter" + ] + }, + { + "id": "11514", + "type": "gene", + "text": "Bertioga ( Guama group ) and Anhembi ( Bunyamwera group ) , two new arboviruses isolated in Sao Paulo , Brazil .", + "entities": [] + }, + { + "id": "11515", + "type": "gene", + "text": "Comparison of cDNA sequences revealed that the two mRNA species arise as a result of alternate use of poly ( A ) - addition sites .", + "entities": [] + }, + { + "id": "11516", + "type": "gene", + "text": "Discordance on the cost dimension correlated negatively with G Hb , suggesting better glycemic control with greater disagreement .", + "entities": [ + "G Hb" + ] + }, + { + "id": "11517", + "type": "gene", + "text": "The average annual cost per head of population was US + 0 X 46 .", + "entities": [] + }, + { + "id": "11518", + "type": "gene", + "text": "Two - way analysis of variance was used to determine whether composite knowledge score differed among patient groups .", + "entities": [] + }, + { + "id": "11519", + "type": "gene", + "text": "In the presence of inositol and choline ( repressing ) , the product of the OPI1 gene represses transcription dictated by the UASINO element .", + "entities": [ + "OPI1 gene" + ] + }, + { + "id": "11520", + "type": "gene", + "text": "Armed with a clear understanding of the pathophysiologic pathways that may cause and / or contribute to the development of unconjugated hyperbilirubinemia and the associated jaundice , the practitioner will be successful in helping the family understand their child ' s illness .", + "entities": [] + }, + { + "id": "11521", + "type": "gene", + "text": "Potential consensus sequences for early and late regulatory elements were identified .", + "entities": [] + }, + { + "id": "11522", + "type": "gene", + "text": "Genomic DNA sequencing in the vicinity of methylmalonyl - CoA mutase gene ( mutAB ) from a rifamycin SV - producing Amycolatopsis mediterranei U32 allowed us to clone , sequence , and identify a gene encoding a novel serine / threonine protein kinase ( amk ) .", + "entities": [ + "methylmalonyl - CoA mutase gene", + "mutAB", + "serine / threonine protein kinase", + "amk" + ] + }, + { + "id": "11523", + "type": "gene", + "text": "Altogether these results indicate that the Syn 5 locus segregates from the gene specifying gH , to a region encompassing portions of the TK and UL 24 genes , and that the syn mutation does not affect the expression or activity of TK .", + "entities": [ + "Syn 5 locus", + "gH", + "TK", + "UL 24 genes", + "syn mutation", + "TK" + ] + }, + { + "id": "11524", + "type": "gene", + "text": "TRAF2 is a potent activator of a 95 - kDa serine / threonine kinase termed germinal center kinase related ( GCKR , also referred to as KHS1 ) , which signals activation of the SAPK pathway .", + "entities": [ + "TRAF2", + "95 - kDa serine / threonine kinase", + "germinal center kinase related", + "GCKR", + "KHS1", + "SAPK" + ] + }, + { + "id": "11525", + "type": "gene", + "text": "Intravenous antibiotic therapy in cystic fibrosis : in hospital or at home ?", + "entities": [] + }, + { + "id": "11526", + "type": "gene", + "text": "Determination of potassium iodide in Polish edible salt", + "entities": [] + }, + { + "id": "11527", + "type": "gene", + "text": "Changes in body weight and agonistic behavior were also recorded .", + "entities": [] + }, + { + "id": "11528", + "type": "gene", + "text": "The P165 component , however , could be differentiated from the two later components since it increased in amplitude with increased task demands while the N2 and P3 amplitudes remained constant .", + "entities": [] + }, + { + "id": "11529", + "type": "gene", + "text": "Symptoms due to the action of mastocyte mediators were observed .", + "entities": [] + }, + { + "id": "11530", + "type": "gene", + "text": "The genomic structure of four members of the SRC - family revealed nearly identical exon / intron boundaries within the catalytic domain of this family .", + "entities": [ + "SRC - family" + ] + }, + { + "id": "11531", + "type": "gene", + "text": "Therefore , the results indicate that repeated exposure to amphetamine or apomorphine overcomes the context - dependent component of sensitization of amphetamine - or apomorphine - induced stereotyped behavior .", + "entities": [] + }, + { + "id": "11532", + "type": "gene", + "text": "The c - myc / TGF - alpha HCCs were also characterized by a particularly strong expression of TGF - alpha and very low apoptotic index in contrast to high levels of apoptosis in peritumorous tissues and c - myc HCCs .", + "entities": [ + "c - myc", + "TGF - alpha", + "TGF - alpha", + "c - myc" + ] + }, + { + "id": "11533", + "type": "gene", + "text": "SELECTION CRITERIA : All randomised controlled trials comparing IUSs with other forms of reversible contraceptives and reporting on pre - determined outcomes in women of reproductive years .", + "entities": [] + }, + { + "id": "11534", + "type": "gene", + "text": "In addition , using biochemical activity assays for Rho - like GTPases , we show that the expression of beta1A , beta1D , or IL2R - beta1A in GE11 or GD25 cells triggers activation of both RhoA and Rac1 , but not of Cdc42 .", + "entities": [ + "Rho", + "GTPases", + "beta1A", + "beta1D", + "IL2R", + "beta1A", + "RhoA", + "Rac1", + "Cdc42" + ] + }, + { + "id": "11535", + "type": "gene", + "text": "A subset of mutations in the Psi synthase domain impairs association of the altered Cbf5p proteins with selected box H / ACA snoRNAs , suggesting that the functional catalytic domain is essential for that interaction .", + "entities": [ + "Psi synthase domain", + "Cbf5p proteins", + "H / ACA snoRNAs" + ] + }, + { + "id": "11536", + "type": "gene", + "text": "Here , we present genetic evidence in Saccharomyces cerevisiae for a functional interaction between the DEAH protein Prp16 , and the U6 and U2 spliceosomal snRNAs .", + "entities": [ + "Prp16", + "U6", + "U2 spliceosomal snRNAs" + ] + }, + { + "id": "11537", + "type": "gene", + "text": "Thus , transcriptional regulation , splicing , kinase interaction sites , and tyrosine phosphorylation of the LMP2A homologs have been conserved despite significant sequences heterogeneity in the preterminal repeat regions of these human and nonhuman primate EBVs .", + "entities": [ + "LMP2A homologs" + ] + }, + { + "id": "11538", + "type": "gene", + "text": "In addition , two - dimensional nuclear magnetic resonance studies with F17A , K13Q , F15Y and F27Y revealed that the mutants have the same overall structure as the wild - type CspB protein .", + "entities": [ + "wild - type CspB protein" + ] + }, + { + "id": "11539", + "type": "gene", + "text": "The procedure has been applied to three materials : particle board with carpet ; gypsum board with wallpaper ; and plywood with polyurethane lacquer , for which the steady - state emission factors ( mg m - 2 h - 1 ) of several compounds are given .", + "entities": [] + }, + { + "id": "11540", + "type": "gene", + "text": "Beta - endorphin , ACTH and cortisol secretion were measured in twelve healthy adult males after nasal spray administration 200 IU salmon calcitonin .", + "entities": [ + "Beta - endorphin", + "ACTH", + "salmon calcitonin" + ] + }, + { + "id": "11541", + "type": "gene", + "text": "In overdoses up to 2 g fluvoxamine no lasting toxic effects were observed .", + "entities": [] + }, + { + "id": "11542", + "type": "gene", + "text": "We have reviewed the experience of a major MMT general practice with hepatitis C virus ( HCV ) infection from 1991 to 1995 .", + "entities": [] + }, + { + "id": "11543", + "type": "gene", + "text": "Weight loss reduces arterial pressure by a decrease in intravascular volume and cardiac output associated with a fall in sympathetic activity .", + "entities": [] + }, + { + "id": "11544", + "type": "gene", + "text": "Factors that showed significant correlation to elevated CIC ' s in the highly elevated portion of our CIC population were poor NIH score , increased patient age , low peak expiratory flow rate , and elevated total serum IgG .", + "entities": [ + "serum IgG" + ] + }, + { + "id": "11545", + "type": "gene", + "text": "Follow - up study showed 85 % of these patients with effectiveness .", + "entities": [] + }, + { + "id": "11546", + "type": "gene", + "text": "The Fas receptor mediates a signalling cascade resulting in programmed cell death ( apoptosis ) within hours of receptor cross - linking .", + "entities": [ + "Fas receptor" + ] + }, + { + "id": "11547", + "type": "gene", + "text": "Dystonic movement of the left upper limb in a case of the right pontine hemorrhage", + "entities": [] + }, + { + "id": "11548", + "type": "gene", + "text": "Potential translational start signals are upstream of ORF1 and ORF2 .", + "entities": [] + }, + { + "id": "11549", + "type": "gene", + "text": "The pharmacology of carnitine .", + "entities": [] + }, + { + "id": "11550", + "type": "gene", + "text": "Primer extension and S1 nuclease mapping experiments were used to locate the transcription initiation site of Nramp1 and revealed the presence of one major and several minor initiation sites .", + "entities": [ + "S1 nuclease", + "Nramp1" + ] + }, + { + "id": "11551", + "type": "gene", + "text": "Moreover , in rats allowed to choose in a T - maze between immediate - but - small vs . delayed - but - large reward , BZP significantly decreased the frequency with which the delayed reward was chosen , with 5 - HT uptake blockers producing opposite effects .", + "entities": [] + }, + { + "id": "11552", + "type": "gene", + "text": "The P131 ORF is followed in - frame by a second ORF which is probably expressed by partial readthrough of the UGA termination codon of the P131 ORF to produce a polypeptide of M ( r ) 191044 ( P191 ) .", + "entities": [] + }, + { + "id": "11553", + "type": "gene", + "text": "These mutants grow normally in 3T6 mouse fibroblast cells , and they do not complement the wild - type virus in coinfection experiments of C2 myoblasts .", + "entities": [] + }, + { + "id": "11554", + "type": "gene", + "text": "Feeding behavior , circannual body weight and hibernation rhythms in European hamsters lesioned in the noradrenergic ascending bundles", + "entities": [] + }, + { + "id": "11555", + "type": "gene", + "text": "Patients were assessed for cardiac MIBG uptake , circulating norepinephrine concentration , LVEF , peak Vo2 , x - ray cardiothoracic ratio , M - mode echographic end - diastolic diameter and right - sided heart catheterization parameters .", + "entities": [] + }, + { + "id": "11556", + "type": "gene", + "text": "The peroxisome proliferator - activated receptors ( PPARs ) are members of the nuclear hormone receptor superfamily .", + "entities": [ + "peroxisome proliferator - activated receptors", + "PPARs", + "nuclear hormone receptor superfamily" + ] + }, + { + "id": "11557", + "type": "gene", + "text": "Another full ORF was found on the opposite strand downstream from the nspC gene .", + "entities": [ + "nspC gene" + ] + }, + { + "id": "11558", + "type": "gene", + "text": "The bile acid sequestrants ( cholestyramine and colestipol ) , nicotinic acid , fenofibrate and inhibitors of hydroxymethylglutaryl coenzyme A ( HMG CoA ) reductase ( e . g . lovastatin or simvastatin ) are the most effective drugs for use in patients with primary hypercholesterolaemia ; these agents reduce plasma concentrations of total and LDL - cholesterol by 15 to 45 % .", + "entities": [ + "hydroxymethylglutaryl coenzyme A ( HMG CoA ) reductase", + "LDL - cholesterol" + ] + }, + { + "id": "11559", + "type": "gene", + "text": "Mutants with mild lace alleles grow to become adults with multiple aberrant morphologies in the appendages , compound eye , and bristles .", + "entities": [ + "lace alleles" + ] + }, + { + "id": "11560", + "type": "gene", + "text": "Both GH deficiency and impaired spinal growth may result in short stature , whereas the occurrence of early puberty in association with GH deficiency reduces the time available for GH therapy .", + "entities": [ + "GH", + "GH", + "GH" + ] + }, + { + "id": "11561", + "type": "gene", + "text": "A rapid staining technique for Leishmania parasites in splenic aspirate smears .", + "entities": [] + }, + { + "id": "11562", + "type": "gene", + "text": "Endothelial cell seeding .", + "entities": [] + }, + { + "id": "11563", + "type": "gene", + "text": "Randomised comparison of addition of autologous bone - marrow transplantation to intensive chemotherapy for acute myeloid leukaemia in first remission : results of MRC AML 10 trial .", + "entities": [] + }, + { + "id": "11564", + "type": "gene", + "text": "The overall prevalence of psoriasis was 4 . 79 % in men and 4 . 85 % in women .", + "entities": [] + }, + { + "id": "11565", + "type": "gene", + "text": "Human papillomavirus type 31b late gene expression is regulated through protein kinase C - mediated changes in RNA processing .", + "entities": [ + "Human papillomavirus type 31b late gene", + "protein kinase C" + ] + }, + { + "id": "11566", + "type": "gene", + "text": "Clinical nutrition of adult horses .", + "entities": [] + }, + { + "id": "11567", + "type": "gene", + "text": "Generally ILC and ILVF values decreased with increasing exposure time with rate constants ranging from 0 . 03 to 0 . 33 day - 1 ( wet and lipid weight ) for ILC and 0 . 03 to 0 . 31 day - 1 for ILVF .", + "entities": [] + }, + { + "id": "11568", + "type": "gene", + "text": "Effects of methylene chloride , trichloroethane , trichloroethylene , tetrachloroethylene and toluene on the development of chick embryos .", + "entities": [] + }, + { + "id": "11569", + "type": "gene", + "text": "The data suggest that ICP10 constitutively increases ras activity , and its TM segment plays a critical role in transformation - related signaling pathways .", + "entities": [ + "ICP10", + "ras" + ] + }, + { + "id": "11570", + "type": "gene", + "text": "Recombinant plasmid pFV100 was subsequently isolated by its ability to complement B - band expression in ge6 .", + "entities": [ + "ge6" + ] + }, + { + "id": "11571", + "type": "gene", + "text": "Before PO3 administration , more than half ( 57 . 4 % ) of the patients received only 1 or 2 antituberculous drugs ( ethambutole and ethionamide or ethambutole and oprofloxacin ) .", + "entities": [] + }, + { + "id": "11572", + "type": "gene", + "text": "Removal of lipid fractions of plant extractions with hexane is recommended to avoid damage to the HPLC column .", + "entities": [] + }, + { + "id": "11573", + "type": "gene", + "text": "In NASCIS III , a randomization imbalance occurred that allocated a disproportionate number of patients with no motor deficit ( and therefore no chance for recovery ) to the lower dose control group .", + "entities": [] + }, + { + "id": "11574", + "type": "gene", + "text": "Neither class II nor IV infections precluded transplantation .", + "entities": [] + }, + { + "id": "11575", + "type": "gene", + "text": "Combined intravenous and intra - arterial recombinant tissue plasminogen activator in acute ischemic stroke .", + "entities": [ + "tissue plasminogen activator" + ] + }, + { + "id": "11576", + "type": "gene", + "text": "The heterogeneous nuclear ribonucleoprotein C protein tetramer binds U1 , U2 , and U6 snRNAs through its high affinity RNA binding domain ( the bZIP - like motif ) .", + "entities": [ + "nuclear ribonucleoprotein C protein tetramer", + "U1", + "U2", + "U6 snRNAs" + ] + }, + { + "id": "11577", + "type": "gene", + "text": "This model is further supported by binding of the Fos - Jun complex at an AP - 1 site in the type alpha I collagen promoter that is contiguous with , but not overlapping , the VDRE .", + "entities": [ + "Fos", + "Jun", + "AP - 1 site", + "type alpha I collagen promoter" + ] + }, + { + "id": "11578", + "type": "gene", + "text": "SCA was resistant to inhibitors of serine , aspartyl , and metalloproteases , but it was sensitive to N - ethylmaleimide .", + "entities": [ + "SCA", + "metalloproteases" + ] + }, + { + "id": "11579", + "type": "gene", + "text": "Mapping of the mouse ornithine decarboxylase - related sequence family .", + "entities": [ + "mouse ornithine decarboxylase - related sequence family" + ] + }, + { + "id": "11580", + "type": "gene", + "text": "These results suggest that mitochondrial presequences interact with the mt - hsp70 during or after mitochondrial protein import .", + "entities": [ + "mt - hsp70" + ] + }, + { + "id": "11581", + "type": "gene", + "text": "40 . 3 + / - 10 . 1 mg / l ( SD ) vs 31 . 2 + / - 8 . 0 , P less than 0 . 01 ) . beta 2m was not significantly higher in patients with bone cysts ( 37 . 7 + / - 11 . 4 mg / l vs 37 . 0 + / - 10 . 0 ) , but median duration of dialysis was significantly ( P less than 0 . 01 ) longer in patients with bone cysts ( 90 vs 57 months ) . beta 2m was lower in patients maintained on dialysis for less than 1 year and whose residual urine volume was greater than 0 . 1 litre per day .", + "entities": [ + "beta 2m", + "beta 2m" + ] + }, + { + "id": "11582", + "type": "gene", + "text": "As the rate of protein synthesis decreases during late embryogenesis , levels of SEC - 1 and its cognate mRNA decline precipitously .", + "entities": [ + "SEC - 1" + ] + }, + { + "id": "11583", + "type": "gene", + "text": "The promoter of the first gene , epiF , responded to the activator protein EpiQ and contained a palindromic sequence similar to the EpiQ binding site of the epiA promoter , which is also activated by EpiQ .", + "entities": [ + "epiF", + "activator protein EpiQ", + "EpiQ binding site", + "epiA promoter", + "EpiQ" + ] + }, + { + "id": "11584", + "type": "gene", + "text": "The altered amino acid residues of the seven mutant 9ORF1 polypeptides clustered within three separate regions referred to as region I ( residues 34 to 41 ) , region II ( residues 89 to 91 ) , and C - terminal region III ( residues 122 to 125 ) .", + "entities": [ + "mutant 9ORF1 polypeptides" + ] + }, + { + "id": "11585", + "type": "gene", + "text": "If no alloantibodies are detected , further analysis to define a role of drug - related or autoantibodies is required .", + "entities": [] + }, + { + "id": "11586", + "type": "gene", + "text": "Notably , these residues are located in different domains .", + "entities": [] + }, + { + "id": "11587", + "type": "gene", + "text": "BACKGROUND : We hypothesized that the postoperative serum level of TA90 - IC , an immune complex of a 90 - kDa tumor - associated antigen and its antibody , might have a significant correlation with recurrence and survival in patients with thick primary melanomas .", + "entities": [ + "TA90 - IC" + ] + }, + { + "id": "11588", + "type": "gene", + "text": "A comparison of the Flavobacterium glycosylasparaginase with a mammalian glycosylasparaginase revealed 30 % structural identity and 60 % overall similarity between the prokaryotic and eukaryotic forms of the enzyme .", + "entities": [ + "glycosylasparaginase", + "glycosylasparaginase" + ] + }, + { + "id": "11589", + "type": "gene", + "text": "Although the DSK2 - 1 mutation alters a conserved residue in the Dsk2p ubiquitin - like domain , we detect no differences in Dsk2p or Cdc31p stability .", + "entities": [ + "DSK2 - 1 mutation", + "ubiquitin - like domain", + "Dsk2p", + "Cdc31p" + ] + }, + { + "id": "11590", + "type": "gene", + "text": "Dangers in use of live - virus vaccines .", + "entities": [] + }, + { + "id": "11591", + "type": "gene", + "text": "The total alkaloids contained in the peel of Atzimba , Lopez , Marciana , Montsama , Murca , and Puebla was lower than the limits recommended for food safety .", + "entities": [] + }, + { + "id": "11592", + "type": "gene", + "text": "Competition experiments demonstrate a negative allosteric relationship between these RGD recognition sites .", + "entities": [] + }, + { + "id": "11593", + "type": "gene", + "text": "A method for determining cumulative behavioral toxicity after chronic oral administration of l - alpha - acetylmethadol to female rats .", + "entities": [] + }, + { + "id": "11594", + "type": "gene", + "text": "In patients with limited disease , the survival in the alternating arm was significantly superior to the survival in the CAV arm ( P = . 014 ) or the survival in the PE arm ( P = . 023 ) .", + "entities": [] + }, + { + "id": "11595", + "type": "gene", + "text": "RESULTS : The parameters SF2 and plating efficiency were stable throughout the 4 - year test period .", + "entities": [] + }, + { + "id": "11596", + "type": "gene", + "text": "2 . numerous narrow shunt vessels departing continuously from the primary arteries to feed a secondary arterial system which parallels the primary one .", + "entities": [] + }, + { + "id": "11597", + "type": "gene", + "text": "Two mutations that affect larval cuticle protein gene expression in the 2 / 3 variant Drosophila melanogaster strain were investigated .", + "entities": [ + "larval cuticle protein gene" + ] + }, + { + "id": "11598", + "type": "gene", + "text": "In another study , intravenous administration of devazepide , a specific cholecystokinin - A receptor antagonist , at a dose of 0 . 1 mg / kg / hr was begun 15 min before postprandial saline intake and continued for 1 hr .", + "entities": [ + "cholecystokinin - A receptor" + ] + }, + { + "id": "11599", + "type": "gene", + "text": "Caries prevention in the dental office .", + "entities": [] + }, + { + "id": "11600", + "type": "gene", + "text": "The 5 ' regions of these two soybean actin genes contain many unusual features including ( CT ) repeats and long stretches of pyrimidine - rich DNA .", + "entities": [ + "soybean actin genes" + ] + }, + { + "id": "11601", + "type": "gene", + "text": "Nuclear extracts prepared from both neural and non - neural cell lines , mouse brain , and mouse liver contain proteins that recognize and bind to the PROX and PAL sequences indicating that proteins which bind to these target sequences are widespread .", + "entities": [] + }, + { + "id": "11602", + "type": "gene", + "text": "Guidelines for performing a routine spiral assay are presented , and alternative test methods intended to overcome a variety of technical difficulties ( such as restricted sample availability , sample viscosity or volatility , etc . ) are recommended .", + "entities": [] + }, + { + "id": "11603", + "type": "gene", + "text": "The levels of NSE and MBP in the IJVB were compared to those in the PVB .", + "entities": [ + "NSE", + "MBP" + ] + }, + { + "id": "11604", + "type": "gene", + "text": "Another group of HIPP - and HCX - lesioned animals trained on the tasks after the lesion showed reduced impairments of the type described above , suggesting that extrahippocampal structures trained after the lesion can assume the role of the hippocampus to some degree .", + "entities": [] + }, + { + "id": "11605", + "type": "gene", + "text": "However , a surprisingly high degree of conservation of intron sequences was observed between both species .", + "entities": [] + }, + { + "id": "11606", + "type": "gene", + "text": "Psychiatric disorders in children and adolescents carry considerable morbidity , impede development , and carry a significant mortality by suicide .", + "entities": [] + }, + { + "id": "11607", + "type": "gene", + "text": "To test the hypothesis that these elements are required for promoter activity , we compared the reporter expression activity of segments containing mutations of these elements with activity of the parent Hlx promoter sequence .", + "entities": [ + "parent Hlx promoter sequence" + ] + }, + { + "id": "11608", + "type": "gene", + "text": "We have used the hydrophobic repeats of the HSF1 trimerization domain in the yeast two - hybrid protein interaction assay to identify heat shock factor binding protein 1 ( HSBP1 ) , a novel , conserved , 76 - amino - acid protein that contains two extended arrays of hydrophobic repeats that interact with the HSF1 heptad repeats .", + "entities": [ + "HSF1 trimerization domain", + "heat shock factor binding protein 1", + "HSBP1", + "HSF1 heptad repeats" + ] + }, + { + "id": "11609", + "type": "gene", + "text": "Renin studies performed in 34 hypertensive patients and in a control group of 11 recipients showed that elevation of plasma renin activity and of plasma aldosterone level is frequent but difficult to interpret , particularly when a renal artery stenosis is observed .", + "entities": [ + "Renin", + "plasma renin" + ] + }, + { + "id": "11610", + "type": "gene", + "text": "Skeletal muscle metaboreceptor responses are impaired in heart failure .", + "entities": [] + }, + { + "id": "11611", + "type": "gene", + "text": "Forty patients , divided according to their initial total gastrointestinal transit times and presenting symptoms , were treated with cimetropium bromide 50 mg t . d . s . or placebo for 1 month according to a double - blind , parallel group design .", + "entities": [] + }, + { + "id": "11612", + "type": "gene", + "text": "An end to the lottery .", + "entities": [] + }, + { + "id": "11613", + "type": "gene", + "text": "In the course of a study of low dose X - rays effects , we found that male ICR white Swiss mice showed remarkable suppression of mounting behavior after whole body irradiation by 5 to 15 cGy X - rays .", + "entities": [] + }, + { + "id": "11614", + "type": "gene", + "text": "Human recombinant DNA - derived antihemophilic factor ( factor VIII ) in the treatment of hemophilia A . recombinant Factor VIII Study Group .", + "entities": [ + "antihemophilic factor", + "factor VIII", + "Factor VIII" + ] + }, + { + "id": "11615", + "type": "gene", + "text": "The model captures the essence of predator - prey dynamics to provide reasonable predictions of population patterns .", + "entities": [] + }, + { + "id": "11616", + "type": "gene", + "text": "In an effort to contribute to the transcript map of human chromosome 21 and the understanding of the pathophysiology of trisomy 21 , we have used exon trapping to identify fragments of chromosome 21 genes .", + "entities": [] + }, + { + "id": "11617", + "type": "gene", + "text": "RT - PCR was performed using previously reported degenerate oligonucleotide primers to the ligand binding domain ( LBD ) of known beta integrin subunits and Bge cDNA .", + "entities": [ + "beta integrin subunits", + "Bge cDNA" + ] + }, + { + "id": "11618", + "type": "gene", + "text": "The p53 - homolog p73beta also activated the PIG3 promoter , but in contrast to p53 , the proline - rich domain of p73beta ( residues 81 - 113 ) was dispensable to induce the PIG3 promoter .", + "entities": [ + "p73beta", + "PIG3 promoter", + "p53", + "p73beta ( residues 81 - 113 )", + "PIG3 promoter" + ] + }, + { + "id": "11619", + "type": "gene", + "text": "Sparfloxacin and clinafloxacin were evaluated against Enterococcus faecium SF2149 and Enterococcus faecalis WH245 , respectively .", + "entities": [] + }, + { + "id": "11620", + "type": "gene", + "text": "Cotransfection of either construct with plasmids encoding PKI ( 1 - 31 ) inhibits cAMP - stimulated but not basal - or phorbol ester - stimulated expression .", + "entities": [ + "PKI ( 1 - 31 )" + ] + }, + { + "id": "11621", + "type": "gene", + "text": "Fourteen healthy male volunteers completed the study .", + "entities": [] + }, + { + "id": "11622", + "type": "gene", + "text": "We have synthesized [ 7 , 7 - 2H2 ] - 19 - OHA with high deuterium content and , together with [ 7 , 7 - 2H2 ] A and [ 9 , 11 - 2H2 ] estrone ( E1 ) , have developed a quantitative assay of serum level 19 - OHA , A , and E1 using the gas chromatography / mass spectrometry - mass fragmentography method to monitor individual subjects throughout pregnancy .", + "entities": [] + }, + { + "id": "11623", + "type": "gene", + "text": "Northern blot analysis , using the Ltp4 - specific probe , indicated that Xanthomonas campestris pv . translucens induced an increase over basal levels of Ltp4 mRNA , while Pseudomonas syringae pv . japonica caused a decrease .", + "entities": [ + "Ltp4", + "Ltp4 mRNA" + ] + }, + { + "id": "11624", + "type": "gene", + "text": "Immunochemical studies with filarial antigens .", + "entities": [] + }, + { + "id": "11625", + "type": "gene", + "text": "Transfection of EGFP - tagged DENTT NLS deletion constructs lacking the bipartite NLS - 1 were excluded from the nucleolus .", + "entities": [ + "EGFP", + "DENTT", + "NLS - 1" + ] + }, + { + "id": "11626", + "type": "gene", + "text": "The experimental results showed that the coagulation - electrooxidation process could efficiently remove the color and the COD from the simulated dye wastewater .", + "entities": [] + }, + { + "id": "11627", + "type": "gene", + "text": "Comparison of the plant nuclear tRNA 3 ' processing enzyme with the plant mitochondrial one suggests that both activities are different enzymes .", + "entities": [] + }, + { + "id": "11628", + "type": "gene", + "text": "Sites 1 and 4 in lumican and keratocan are in a homologous location .", + "entities": [ + "lumican", + "keratocan" + ] + }, + { + "id": "11629", + "type": "gene", + "text": "Thus , both the hyperplasia and thrombotic complications which often follow stenting might be minimized by employing gold stents , which have a greater capacity than steel in supporting a functional neo - endothelium .", + "entities": [] + }, + { + "id": "11630", + "type": "gene", + "text": "Ischemic heart disease evaluated by exercise stress thallium - 201 myocardial scintigraphy : a comparison of SPECT and bull ' s eye display", + "entities": [] + }, + { + "id": "11631", + "type": "gene", + "text": "Baseline MBF in females was significantly ( P < 0 . 001 ) higher than in males .", + "entities": [] + }, + { + "id": "11632", + "type": "gene", + "text": "The effects of these mutations on RNA polymerase II activity were assayed by measuring the ability of mutant genes to confer alpha - amanitin resistance after transfection of susceptible rodent cells .", + "entities": [ + "RNA polymerase II", + "alpha - amanitin" + ] + }, + { + "id": "11633", + "type": "gene", + "text": "Maximum induction of AP - 1 was reached at a concentration of 250 nmol / L of CalC .", + "entities": [ + "AP - 1" + ] + }, + { + "id": "11634", + "type": "gene", + "text": "Risk factors influencing lymph nodes metastasis in lung cancer with stage I , II or IIIA", + "entities": [] + }, + { + "id": "11635", + "type": "gene", + "text": "The Schistosoma mansoni homologue ( SmSmad2 ) was overexpressed in bacteria as a Sj26 - GST fusion protein and used to raise specific antibodies .", + "entities": [ + "Schistosoma mansoni homologue", + "SmSmad2", + "Sj26", + "GST" + ] + }, + { + "id": "11636", + "type": "gene", + "text": "Histopathologic response of gingival tissues to hemodent and aluminum chloride solutions as tissue displacement materials .", + "entities": [] + }, + { + "id": "11637", + "type": "gene", + "text": "Sinusoidal oscillations of a gas dilution indicator", + "entities": [] + }, + { + "id": "11638", + "type": "gene", + "text": "In fus3 mutants , the levels of Ty1 RNA , protein synthesis , and proteolytic processing were not altered relative to those in FUS3 strains but steady - state levels of TyA , integrase , and reverse transcriptase proteins and Ty1 cDNA were all increased .", + "entities": [ + "fus3 mutants", + "Ty1 RNA", + "FUS3", + "TyA", + "integrase", + "reverse transcriptase", + "Ty1 cDNA" + ] + }, + { + "id": "11639", + "type": "gene", + "text": "Deletion of the last two Ser residues , including one PKC consensus site in the receptor tail , prevented only phorbol 12 - myristate 13 - acetate - induced desensitization by 30 % .", + "entities": [ + "PKC" + ] + }, + { + "id": "11640", + "type": "gene", + "text": "Ig D - JH recombinations may precede TcR gene recombination in these early T cell lines , and some but not all express sterile Cmu transcripts .", + "entities": [ + "Ig D", + "JH", + "TcR gene", + "Cmu transcripts" + ] + }, + { + "id": "11641", + "type": "gene", + "text": "The data provide evidence both for a signal transduction pathway independent of JNK , ERK , and p38 MAP kinase to be involved in the induction of rhoB by genotoxic stress , and furthermore , indicate autoregulation of rhoB .", + "entities": [ + "JNK", + "ERK", + "MAP kinase", + "rhoB", + "rhoB" + ] + }, + { + "id": "11642", + "type": "gene", + "text": "In addition , negatively regulatory region may exist from - 1782 to - 1295 bp .", + "entities": [] + }, + { + "id": "11643", + "type": "gene", + "text": "Post - operative functional outcome is related to pre - operative functional status .", + "entities": [] + }, + { + "id": "11644", + "type": "gene", + "text": "Blood samples were obtained daily during this supplementation period and 5 d thereafter ( d 11 to 15 ) .", + "entities": [] + }, + { + "id": "11645", + "type": "gene", + "text": "The use of an appropriate solution of methylene blue ( 0 . 2 % in 0 . 9 M NaCl for 15 min ) permits the staining of premalignant areas and CIS , and their early diagnosis .", + "entities": [] + }, + { + "id": "11646", + "type": "gene", + "text": "The assay herein described allows the comparison of relative FGFR expression levels , both within a single RNA pool and among multiple RNA pool samples .", + "entities": [ + "FGFR" + ] + }, + { + "id": "11647", + "type": "gene", + "text": "The putative immunity protein was detected among the [ 35S ] methionine - labelled proteins produced by minicells carrying cni cloned under lac promoter control , and when the gene was subcloned into expression vectors under the control of a bacteriophage T7 promoter .", + "entities": [ + "cni", + "lac promoter" + ] + }, + { + "id": "11648", + "type": "gene", + "text": "The mutant receptors , as well as sBMPR - IA , were expressed as fusion proteins with thioredoxin in Escherichia coli , and purified using reverse phase high performance liquid chromatography ( RP - HPLC ) after digestion with enterokinase .", + "entities": [ + "sBMPR - IA", + "thioredoxin", + "enterokinase" + ] + }, + { + "id": "11649", + "type": "gene", + "text": "Interlimb coordination during fictive locomotion in the thalamic cat .", + "entities": [] + }, + { + "id": "11650", + "type": "gene", + "text": "The plasmin - derived D ( approximately 105 - kDa ) product , however , could be cross - linked into DD dimers .", + "entities": [ + "plasmin - derived D ( approximately 105 - kDa ) product" + ] + }, + { + "id": "11651", + "type": "gene", + "text": "We also provide evidence that neither the lambda O and P initiators nor the E . coli DnaJ and DnaK heat shock proteins play a direct role in the propagation of lambda replication forks in vitro .", + "entities": [ + "lambda O", + "P initiators", + "E . coli DnaJ", + "DnaK" + ] + }, + { + "id": "11652", + "type": "gene", + "text": "Using Scheffe ' s procedure as an illustration , comparisons are made to usual sample size methods that incorrectly ignore the stochastic nature of S2p .", + "entities": [] + }, + { + "id": "11653", + "type": "gene", + "text": "[ Ala85 ] Dk ( 69 - 85 ) retains full biological activity .", + "entities": [ + "[ Ala85 ] Dk ( 69 - 85 )" + ] + }, + { + "id": "11654", + "type": "gene", + "text": "To assess the ability of the atria to maintain elevated plasma concentrations of atrial natriuretic peptide ( ANP ) , the temporal changes in plasma ANP concentrations were studied in seven chloralose - anaesthetized dogs during 4 h of sustained rapid cardiac pacing .", + "entities": [ + "atrial natriuretic peptide", + "ANP", + "plasma ANP" + ] + }, + { + "id": "11655", + "type": "gene", + "text": "Furthermore , beta 2 - adrenoceptor sensitivity appears to be unaltered in BHT .", + "entities": [ + "beta 2 - adrenoceptor" + ] + }, + { + "id": "11656", + "type": "gene", + "text": "Ten out of 10 patients with progressive disease had mast cells greater than or equal to 0 . 5 % , hyaluronan greater than or equal to 50 micrograms . l - 1 and fibronectin greater than or equal to 350 micrograms . l - 1 compared to eight out of 41 patients with stable or regressive disease . ( ABSTRACT TRUNCATED AT 250 WORDS )", + "entities": [ + "fibronectin" + ] + }, + { + "id": "11657", + "type": "gene", + "text": "When voltage - operated Ca2 + channels ( VOC ) were blocked by nifedipine , midazolam , in concentrations more than 1 microM , attenuated both phasic and tonic responses .", + "entities": [] + }, + { + "id": "11658", + "type": "gene", + "text": "Tonometry of blood samples from patients may also be used in the determination of acid - base quantities and hemoglobin - oxygen affinity e . g . p50 .", + "entities": [ + "hemoglobin" + ] + }, + { + "id": "11659", + "type": "gene", + "text": "Evaluation of desmopressin for dental extractions in patients with hemostatic disorders .", + "entities": [] + }, + { + "id": "11660", + "type": "gene", + "text": "This is based on partitioning an underlying multivariate normal distribution .", + "entities": [] + }, + { + "id": "11661", + "type": "gene", + "text": "We discuss the results in relation to previous systems for parcellating the posterior ectosylvian gyrus of the cat and consider the possibility that divisions of the feline posterior ectosylvian gyrus correspond directly to areas making up the superior temporal gyrus in primates .", + "entities": [] + }, + { + "id": "11662", + "type": "gene", + "text": "At the MTD ( 8 mg / m2 / day ) , the dose - limiting toxicity of this agent is myelosuppression .", + "entities": [] + }, + { + "id": "11663", + "type": "gene", + "text": "However , the abi1 - 1 gene product has no effect on the ABA suppression of a GA - responsive alpha - amylase gene .", + "entities": [ + "abi1 - 1 gene product", + "alpha - amylase gene" + ] + }, + { + "id": "11664", + "type": "gene", + "text": "Mastocytosis .", + "entities": [] + }, + { + "id": "11665", + "type": "gene", + "text": "Although differences were not significant , infants in the experimental group had more changes in the intermittent mandatory ventilation ( IMV ) settings during transport , and more such infants arrived at the receiving hospital with acceptable pH and PCO2 values .", + "entities": [] + }, + { + "id": "11666", + "type": "gene", + "text": "Hu - Met - 1 mRNA expression in a small number of human T cell tumor lines did not correlate with any particular phenotype or stage of development .", + "entities": [ + "Hu - Met - 1 mRNA" + ] + }, + { + "id": "11667", + "type": "gene", + "text": "Mucoepidermoid and acinous cell carcinomas of salivary tissues .", + "entities": [] + }, + { + "id": "11668", + "type": "gene", + "text": "Interactions between adrenergics , adrenolytics and monoamine oxidase inhibitors", + "entities": [ + "monoamine oxidase" + ] + }, + { + "id": "11669", + "type": "gene", + "text": "176 : 787 - 792 , 1992 ; M .", + "entities": [] + }, + { + "id": "11670", + "type": "gene", + "text": "The pattern and timing of CARP mRNA expression , including transient expression in the tongue at 14 . 5 days p . c . , coincides with that of Nkx2 . 5 / Csx ( a putative homolog of tinman , the Drosophila melanogaster gene responsible for cardiac development ) .", + "entities": [ + "CARP mRNA", + "Nkx2 . 5", + "Csx", + "tinman" + ] + }, + { + "id": "11671", + "type": "gene", + "text": "The experimental design incorporated a multiple regression model , sequential treatments and a proportional end point ( 95 % ) for protection time .", + "entities": [] + }, + { + "id": "11672", + "type": "gene", + "text": "Because the CAP measures variables predictive of abusive behavior , a substantial relationship was expected between the CAP and the MHI Loss of Behavioral / Emotional Control scale .", + "entities": [] + }, + { + "id": "11673", + "type": "gene", + "text": "The feed consumed which was lowered by 25 % initially , did not alter later .", + "entities": [] + }, + { + "id": "11674", + "type": "gene", + "text": "Mechanism of interferon action : identification of essential positions within the novel 15 - base - pair KCS element required for transcriptional activation of the RNA - dependent protein kinase pkr gene .", + "entities": [ + "interferon", + "15 - base - pair KCS element", + "RNA - dependent protein kinase pkr gene" + ] + }, + { + "id": "11675", + "type": "gene", + "text": "Although diagnostic laparoscopy is still considered the standard reference in the diagnosis of ectopic pregnancy ( EP ) , use of high - resolution endovaginal sonography , in conjunction with qualitative serum assays of the beta subunit of human chorionic gonadotropin ( beta - hCG ) , allows detection of earlier and smaller EPs .", + "entities": [ + "human chorionic gonadotropin", + "beta - hCG" + ] + }, + { + "id": "11676", + "type": "gene", + "text": "The German Society of Pediatric Oncology in 1981 initiated the Cooperative Ewing ' s Sarcoma Study ( CESS 81 ) using a four - drug combination of chemotherapy prior to definitive local control with surgery and / or radiation .", + "entities": [] + }, + { + "id": "11677", + "type": "gene", + "text": "Lactate accumulation peak was unaffected by supplementation ( HMB , 8 . 1 + / - 1 . 1 mM ; LEU , 6 . 2 + / - 0 . 8 mM ; CON , 7 . 5 + / - 1 . 3 mM ) .", + "entities": [] + }, + { + "id": "11678", + "type": "gene", + "text": "Arm function tests .", + "entities": [] + }, + { + "id": "11679", + "type": "gene", + "text": "PURPOSE : The role interleukin - 6 ( IL - 6 ) in the treatment of congenital thrombocytopenias is unknown .", + "entities": [ + "interleukin - 6", + "IL - 6" + ] + }, + { + "id": "11680", + "type": "gene", + "text": "Gng3lg transcripts are expressed in a variety of tissues including both brain and testes .", + "entities": [ + "Gng3lg transcripts" + ] + }, + { + "id": "11681", + "type": "gene", + "text": "The qualitative concentrations of HCG had a sensitivity of 37 . 5 % and a specificity of 100 % .", + "entities": [ + "HCG" + ] + }, + { + "id": "11682", + "type": "gene", + "text": "Four ruminally and duodenally cannulated Hampshire wethers were used in a 4 x 4 Latin square experiment to determine whether linoleoyl methionine and calcium linoleate would increase duodenal flow of unsaturated fatty acids ( C18 : 2 + cis C18 : 1 ) .", + "entities": [] + }, + { + "id": "11683", + "type": "gene", + "text": "Effect of time and dose on alterations following inhalation of plutonium - 239 dioxide aerosol in rat .", + "entities": [] + }, + { + "id": "11684", + "type": "gene", + "text": "Cimetidine 800 mg given at night is as effective as 400 mg twice daily ; the single dose regimen may improve patient compliance , thus facilitating treatment .", + "entities": [] + }, + { + "id": "11685", + "type": "gene", + "text": "Plasma , LDL and liver cholesterol concentrations were higher in the hyperlipidemic control than the nonhyperlipidemic control and lower in the groups fed diets containing pectin or prune fiber than in the hyperlipidemic control group .", + "entities": [ + "LDL", + "pectin" + ] + }, + { + "id": "11686", + "type": "gene", + "text": "Liver TG and serum NEFA concentrations were positively correlated .", + "entities": [] + }, + { + "id": "11687", + "type": "gene", + "text": "Nine DNA fragments that were specifically recognized and bound by histidine - tagged AdpA were isolated by cycles of a gel mobility shift - PCR method .", + "entities": [ + "AdpA" + ] + }, + { + "id": "11688", + "type": "gene", + "text": "( 3 ) .", + "entities": [] + }, + { + "id": "11689", + "type": "gene", + "text": "To assess more specific PKA - dependent mediation of LH ' s contribution to combined hormonal drive , the LDL receptor ( - 1076 to + 11 bp ) reporter plasmid was cotransfected with a full - sequence rabbit muscle protein kinase inhibitor ( PKI ) minigene driven constitutively by a Rous sarcoma virus promoter .", + "entities": [ + "PKA", + "LH ' s", + "LDL receptor ( - 1076 to + 11 bp ) reporter", + "full - sequence rabbit muscle protein kinase inhibitor", + "PKI", + "Rous sarcoma virus promoter" + ] + }, + { + "id": "11690", + "type": "gene", + "text": "Lys ( 193 ) and Arg ( 194 ) , located at the COOH - terminal end of HD , are essential for dimerization .", + "entities": [ + "HD" + ] + }, + { + "id": "11691", + "type": "gene", + "text": "Copyright 1998 Elsevier Science B . V .", + "entities": [] + }, + { + "id": "11692", + "type": "gene", + "text": "We have tested this possibility by constructing a consecutive series of cysteine substitutions in the Neu juxtamembrane domain in order to force dimerization along a series of interreceptor faces .", + "entities": [ + "Neu juxtamembrane domain" + ] + }, + { + "id": "11693", + "type": "gene", + "text": "Although no differences were noted in the decrease in platelet counts between the two groups , fibrinogen levels and alpha 2 - antiplasmin levels declined less drastically in the antithrombin - treated group .", + "entities": [ + "fibrinogen", + "alpha 2 - antiplasmin", + "antithrombin" + ] + }, + { + "id": "11694", + "type": "gene", + "text": "A decrease of the lysozyme activity coincided with the clinical improvement of the bacterial meningitis .", + "entities": [ + "lysozyme" + ] + }, + { + "id": "11695", + "type": "gene", + "text": "HBx strongly elevates levels of GTP - bound Ras , activated and phosphorylated Raf , and tyrosine - phosphorylated and activated MAP kinase .", + "entities": [ + "HBx", + "Ras", + "Raf", + "MAP kinase" + ] + }, + { + "id": "11696", + "type": "gene", + "text": "Hypothalamic control of coronary circulation in the dog .", + "entities": [] + }, + { + "id": "11697", + "type": "gene", + "text": "Progressive study and robustness test of QSAR model based on quantum chemical parameters for predicting BCF of selected polychlorinated organic compounds ( PCOCs ) .", + "entities": [] + }, + { + "id": "11698", + "type": "gene", + "text": "Forty - eight pigs were removed from sows at 1 d of age and randomly assigned to one of three treatments : 1 ) control with lactose as the carbohydrate source , 2 ) lactose replaced ( gram for gram ) with CSS ( dextrose equivalent [ DE ] - 20 ) , and 3 ) lactose replaced with DE - 42 .", + "entities": [] + }, + { + "id": "11699", + "type": "gene", + "text": "Double - blind randomised trial of intravenous tissue - type plasminogen activator versus placebo in acute myocardial infarction .", + "entities": [ + "tissue - type plasminogen activator" + ] + }, + { + "id": "11700", + "type": "gene", + "text": "Clb / Cdc28 kinases promote nuclear export of the replication initiator proteins Mcm2 - 7 .", + "entities": [ + "Clb", + "Cdc28", + "replication initiator proteins Mcm2 - 7" + ] + }, + { + "id": "11701", + "type": "gene", + "text": "Specific class I and II histone deacetylases ( HDACs ) interact in vivo with BCoR , suggesting that BCoR may functionally link these two classes of HDACs .", + "entities": [ + "class I and II histone deacetylases", + "HDACs", + "BCoR", + "BCoR", + "HDACs" + ] + }, + { + "id": "11702", + "type": "gene", + "text": "MRI disclosed one or more of the following abnormalities in 24 ( 63 % ) of 38 treated kidneys : ( 1 ) loss of corticomedullary differentiation , ( 2 ) perirenal fluid , ( 3 ) subcapsular hematoma , ( 4 ) hemorrhage into a renal cyst , and ( 5 ) unexplained abnormalities .", + "entities": [] + }, + { + "id": "11703", + "type": "gene", + "text": "Stereotactic radiofrequency lesioning of the hamartoma resulted in seizure remission without complications 20 months after surgery .", + "entities": [] + }, + { + "id": "11704", + "type": "gene", + "text": "Hypersplenism", + "entities": [] + }, + { + "id": "11705", + "type": "gene", + "text": "This proposed method is similar in principle to the sets technique but is shown to have much better expected time to alarm properties .", + "entities": [] + }, + { + "id": "11706", + "type": "gene", + "text": "The grandfather and the granddaughter both had microtia and meatal atresia , whereas the daughter had a normal outer ear except for a narrow meatus and auricular appendages .", + "entities": [] + }, + { + "id": "11707", + "type": "gene", + "text": "The Ishasha samples show a range encompassing three trophic levels .", + "entities": [] + }, + { + "id": "11708", + "type": "gene", + "text": "Patients at risk of hypothyroidism .", + "entities": [] + }, + { + "id": "11709", + "type": "gene", + "text": "These natural antisense S transcripts co - exist with several less abundant sense S transcripts .", + "entities": [ + "S transcripts", + "S transcripts" + ] + }, + { + "id": "11710", + "type": "gene", + "text": "Mechanism of activation of the vav protooncogene . vav is a human locus that appears to be specifically expressed in cells of hematopoietic origin regardless of their differentiation lineage .", + "entities": [ + "vav protooncogene", + "vav" + ] + }, + { + "id": "11711", + "type": "gene", + "text": "Two closely related IgH constant region genes , CHA and CHB , have been sequenced completely .", + "entities": [ + "IgH", + "CHA", + "CHB" + ] + }, + { + "id": "11712", + "type": "gene", + "text": "Basal midexpiratory lower esophageal sphincter pressure was similar in the study group ( mean [ SD ] 20 . 1 [ 9 . 1 ] mmHg ) and controls ( 17 . 6 [ 6 . 0 ] mmHg ) ; the pressure did not change following EVS or EVL .", + "entities": [] + }, + { + "id": "11713", + "type": "gene", + "text": "The hydrophobicity profile of the methyltransferase reveals the presence of at least five potential transmembrane domains .", + "entities": [] + }, + { + "id": "11714", + "type": "gene", + "text": "The sequence - specific interaction of nuclear factor HiNF - D with this key proximal promoter element of the H4 - FO108 gene is cell cycle regulated in normal diploid cells ( J .", + "entities": [ + "nuclear factor HiNF - D", + "H4 - FO108 gene" + ] + }, + { + "id": "11715", + "type": "gene", + "text": "METHODS : IgG antibodies vs HHV - 6 ( anti - HHV - 6 - IgG ) were determined by indirect immunofluorescence in 100 IVDA ( 29 seronegative and 71 seropositive for HIV - 1 of which 45 were in stage II and 26 in IV - C1 of CDC ) as well as in 100 healthy subjects of a similar age ( control group ) .", + "entities": [ + "IgG antibodies", + "anti - HHV - 6 - IgG" + ] + }, + { + "id": "11716", + "type": "gene", + "text": "Diet therapy with soy proteins for chronic stomach ulcers", + "entities": [] + }, + { + "id": "11717", + "type": "gene", + "text": "Despite i . v . steroid therapy , [ NOexh ] remained elevated throughout recovery ( 37 . 9 + / - 4 . 8 ppb , p < 0 . 001 ) until discharge ( 40 . 9 + / - 4 . 3 ppb , p < 0 . 001 ) .", + "entities": [] + }, + { + "id": "11718", + "type": "gene", + "text": "Peripheral metabolism of androgens takes place in various areas within the pilosebaceous unit , as indicated by local differences in the activities of aromatase , 5alpha - reductase as well as of the presence of the androgen receptors .", + "entities": [ + "aromatase", + "5alpha - reductase", + "androgen receptors" + ] + }, + { + "id": "11719", + "type": "gene", + "text": "Breast - fed newborn infants synthesize n - 6 long - chain polyunsaturated fatty acids already during the first week of life , but the contribution of endogenous synthesis to the total plasma long - chain polyunsaturated pool is small .", + "entities": [] + }, + { + "id": "11720", + "type": "gene", + "text": "Marked racial variation in birthweight percentiles by gestational age was evident .", + "entities": [] + }, + { + "id": "11721", + "type": "gene", + "text": "Deflunia was well tolerated by 25 patients , very well tolerated by 2 .", + "entities": [] + }, + { + "id": "11722", + "type": "gene", + "text": "It is striking that the active CHO spacer promoter violated the otherwise universal rule that metazoan RNA polymerase I promoters all have a G residue at position - 16 .", + "entities": [ + "metazoan RNA polymerase I promoters" + ] + }, + { + "id": "11723", + "type": "gene", + "text": "In situ copper - phenanthroline footprinting of individual gel shift assembly intermediates shows that on the 302 - nucleotide G4oric , the first two SSB tetramers assemble at random , but the addition of more SSB tetramers results in formation of a unique structure .", + "entities": [ + "SSB tetramers", + "SSB tetramers" + ] + }, + { + "id": "11724", + "type": "gene", + "text": "Here , we propose that an antagonistic , BMP / ALK2 / Smad - mediated signaling pathway is active on the right side of the Xenopus embryo .", + "entities": [ + "BMP", + "ALK2", + "Smad" + ] + }, + { + "id": "11725", + "type": "gene", + "text": "In order to decipher the pathway that leads to Hox gene induction , we have investigated whether a Hox gene regulator , the leucine zipper transcription factor MafB / Kr , is itself transcriptionally regulated by the environmental signals .", + "entities": [ + "Hox gene", + "Hox gene", + "MafB", + "Kr" + ] + }, + { + "id": "11726", + "type": "gene", + "text": "Thus , the N - Nus complex may be affected through contacts with the CTD of the alpha subunit of RNA polymerase , as is a group of regulatory proteins that influences initiation of transcription .", + "entities": [ + "N", + "Nus", + "RNA polymerase" + ] + }, + { + "id": "11727", + "type": "gene", + "text": "We report a prevalence study of the best visual acuity in the affected eye of 100 selected patients with herpetic keratitis seen during a two - year period .", + "entities": [] + }, + { + "id": "11728", + "type": "gene", + "text": "Somatostatin - producing endocrine pancreatic tumor in Recklinghausen ' s neurofibromatosis .", + "entities": [ + "Somatostatin" + ] + }, + { + "id": "11729", + "type": "gene", + "text": "The promoter and upstream region of the Brassica napus 2S storage protein napA gene were studied to identify cis - acting sequences involved in developmental seed - specific expression .", + "entities": [ + "Brassica napus 2S storage protein napA gene" + ] + }, + { + "id": "11730", + "type": "gene", + "text": "Here , we show that IRF - 1 is degraded via the ubiquitin - proteasome pathway .", + "entities": [ + "IRF - 1", + "ubiquitin" + ] + }, + { + "id": "11731", + "type": "gene", + "text": "On the basis of serological studies , the highly conserved A domain of HspA was found to be the immunodominant domain .", + "entities": [ + "HspA" + ] + }, + { + "id": "11732", + "type": "gene", + "text": "Fibrin cloaking along the catheter was found in 20 patients studied by pull - out arteriography and was unassociated with clinical symptoms .", + "entities": [ + "Fibrin" + ] + }, + { + "id": "11733", + "type": "gene", + "text": "In the remaining case , the aneurysm originated from the proximal end of the associated A1 fenestration .", + "entities": [] + }, + { + "id": "11734", + "type": "gene", + "text": "TATA and CCAAT boxes are located 34 - bp and 68 - bp , respectively , upstream of the transcription start site , the 5 ' - untranslated leader is 78 nucleotides long , and the intronless gene has at least two different polyadenylation sites .", + "entities": [] + }, + { + "id": "11735", + "type": "gene", + "text": "Sevelamer hydrochloride ( Renagel ) is a nonabsorbed phosphate - binding polymer marketed for the treatment of hyperphosphatemia in adult patients receiving hemodialysis .", + "entities": [] + }, + { + "id": "11736", + "type": "gene", + "text": "The addition of a Paf - containing extract does not lead to significant protein binding to these two hly target sequences in the absence of PrfA but converts the complex ( CIII ) consisting of PrfA and the 109 bp hly DNA fragment to a slower migrating PrfA - Paf - DNA complex ( CI ) .", + "entities": [ + "Paf", + "hly target sequences", + "PrfA", + "PrfA", + "109 bp hly DNA fragment", + "PrfA", + "Paf" + ] + }, + { + "id": "11737", + "type": "gene", + "text": "Construction of human cell lines which contain and express the adenovirus DNA binding protein gene by cotransformation with the HSV - 1 tk gene .", + "entities": [ + "HSV - 1 tk gene" + ] + }, + { + "id": "11738", + "type": "gene", + "text": "We conclude that solidification could occur in all feeds containing casein and that alternative feeds should be considered in patients with increased gastric acidity .", + "entities": [ + "casein" + ] + }, + { + "id": "11739", + "type": "gene", + "text": "356 , 93 - 98 ] .", + "entities": [] + }, + { + "id": "11740", + "type": "gene", + "text": "Promoter analysis demonstrated that the sequence identical to consensus cAMP - responsive element ( CRE ) located at - 481 of the SMemb promoter was critical for Hex responsiveness .", + "entities": [ + "SMemb promoter", + "Hex" + ] + }, + { + "id": "11741", + "type": "gene", + "text": "The cDNA was expressed in Saccharomyces cerevisiae under the control of the yeast triose phosphate isomerase promoter .", + "entities": [ + "yeast triose phosphate isomerase promoter" + ] + }, + { + "id": "11742", + "type": "gene", + "text": "The EC ( 50 ) for suppression of long - term memory ( the concentration decreasing memory by 50 % ) of fear conditioning to context was 2 . 00 % plus / minus 0 . 01 % ( mean plus / minus SEM ) , and for fear conditioning to tone was 3 . 45 % plus / minus 0 . 26 % , ( P < 0 . 05 ) .", + "entities": [] + }, + { + "id": "11743", + "type": "gene", + "text": "Extensive DNA rearrangement occurs during the development of the somatic macronucleus from the germ line micronucleus in ciliated protozoans .", + "entities": [] + }, + { + "id": "11744", + "type": "gene", + "text": "Twenty - eight were excluded as gallstones were not proved : of the remainder , 21 patients received glucagon and 22 placebo .", + "entities": [ + "glucagon" + ] + }, + { + "id": "11745", + "type": "gene", + "text": "A recombinant derivative harboring the pMJ101 replication region proved to be compatible with pJM1 , a plasmid containing the iron acquisition system required for the virulence of V . anguillarum 775 , another important pathogen that causes vibriosis .", + "entities": [] + }, + { + "id": "11746", + "type": "gene", + "text": "The mean power ( in mu W ) required to produce the observed flow rate was estimated at each outflow pressure as the product of the flow rate and the pressure across the lymphatic vessel .", + "entities": [] + }, + { + "id": "11747", + "type": "gene", + "text": "By applying the potentiometric method , in aqueous medium of ionic strength mu = 0 . 2 , the stability constants , log beta 1 = 4 . 42 and log beta 2 = 8 . 57 were obtained .", + "entities": [] + }, + { + "id": "11748", + "type": "gene", + "text": "Aggregation of vHnf1 - deficient embryonic stem cells with wild - type tetraploid embryos , which contribute exclusively to extraembryonic tissues , rescues periimplantation lethality and allows development to progress to early organogenesis .", + "entities": [ + "vHnf1" + ] + }, + { + "id": "11749", + "type": "gene", + "text": "METHODS AND RESULTS : A 64 - year - old woman with confirmed AV nodal reentrant tachycardia underwent a successful \" slow pathway \" AV modification with a single radiofrequency application .", + "entities": [] + }, + { + "id": "11750", + "type": "gene", + "text": "Adding phytase and nP improved the orderliness of development , mineralization and arrangement of cartilage and bone cells , and alleviated the effects of P deficiency on the histological and gross structure of the tibias .", + "entities": [ + "phytase" + ] + }, + { + "id": "11751", + "type": "gene", + "text": "We have elucidated the exon - intron organization of the entire human CD58 gene , including approximately 2 . 5 kilobases ( kb ) of 5 ' - flanking DNA .", + "entities": [ + "CD58 gene" + ] + }, + { + "id": "11752", + "type": "gene", + "text": "The tumor suppressor and transcriptional factor p53 is a phosphorylated protein .", + "entities": [ + "p53" + ] + }, + { + "id": "11753", + "type": "gene", + "text": "The cDNA contained an open reading frame of 1392 bp that predicted a protein of 464 amino acids and a molecular mass of 52 kDa ; this protein has 97 % identity to rat liver glucokinase .", + "entities": [ + "rat liver glucokinase" + ] + }, + { + "id": "11754", + "type": "gene", + "text": "Nutritional cataracts in timber wolves .", + "entities": [] + }, + { + "id": "11755", + "type": "gene", + "text": "Electrophoretic mobility shift analysis indicates that NF - IL - 6 , as well as other related members of this family , bind specifically to the NF - IL - 6 site in the IL - 8 promoter .", + "entities": [ + "NF - IL - 6", + "NF - IL - 6", + "IL - 8 promoter" + ] + }, + { + "id": "11756", + "type": "gene", + "text": "Use of Selenastrum capricornutum and Microfeast as food for Daphnia pulex .", + "entities": [] + }, + { + "id": "11757", + "type": "gene", + "text": "These data indicate that RNK - Met - 1 is a serine protease with unique activity that is expressed in the granules of large granular lymphocytes .", + "entities": [ + "RNK - Met - 1", + "serine protease" + ] + }, + { + "id": "11758", + "type": "gene", + "text": "After nadolol , heart rate decreased ( - 22 + / - 8 % ) , and so did PBV and PBF ( 8 . 8 + / - 3 . 4 vs .", + "entities": [] + }, + { + "id": "11759", + "type": "gene", + "text": "Phosphotyrosyl peptides block Stat3 - mediated DNA binding activity , gene regulation , and cell transformation .", + "entities": [ + "Stat3" + ] + }, + { + "id": "11760", + "type": "gene", + "text": "Inclusion of the extended N terminus into the originally reported protein resulted in a striking similarity to the lymphoid factor Lef - 1 .", + "entities": [ + "lymphoid factor Lef - 1" + ] + }, + { + "id": "11761", + "type": "gene", + "text": "There was a 2 . 4 - fold difference in CAT produced from these transcripts in HeLa cells , which contain a greater natural abundance of PTB .", + "entities": [ + "CAT", + "PTB" + ] + }, + { + "id": "11762", + "type": "gene", + "text": "Closure of the patent ductus arteriosus with a Ligaclip through a minithoracotomy .", + "entities": [] + }, + { + "id": "11763", + "type": "gene", + "text": "In addition , all three Opa proteins of C751 bind equally well to HeLa cells transfected with cDNA encoding the carcinoembryonic antigen [ CEA ( CD66e ) ] subgroup of the CD66 family , but show distinct tropism for CGM1 - ( CD66d ) and NCA ( CD66c ) - expressing cells .", + "entities": [ + "Opa proteins", + "carcinoembryonic antigen", + "CEA", + "CD66e", + "CD66 family", + "CGM1", + "CD66d", + "NCA", + "CD66c" + ] + }, + { + "id": "11764", + "type": "gene", + "text": "Surgical treatment of pulmonary metastases .", + "entities": [] + }, + { + "id": "11765", + "type": "gene", + "text": "Using a series of mutant T antigens expressed by recombinant baculoviruses in Sf9 cells , we find that the origin unwinding activities of both TS677 - - > A and TS677 , 679 - - > A are inhibited by the T - antigen kinase , as is wild - type T antigen .", + "entities": [ + "mutant T antigens", + "T - antigen kinase", + "wild - type T antigen" + ] + }, + { + "id": "11766", + "type": "gene", + "text": "We recently reported the molecular cloning of a PL scramblase of human ( HuPLSCR1 ) and mouse origin , respectively .", + "entities": [ + "PL scramblase", + "HuPLSCR1" + ] + }, + { + "id": "11767", + "type": "gene", + "text": "1 , 3 - bis ( 2 - chloroethyl ) - 1 - nitrosourea ( bcnu ) and other nitrosoureas in cancer treatment : a review .", + "entities": [] + }, + { + "id": "11768", + "type": "gene", + "text": "Acute decrease in body temperature ( TB ) lowered PaCO2 ( 32 . 5 to 14 . 5 mmHg ) and [ HCO3 - ] a ( 24 . 20 mEq / L to 17 . 56 mEq / L ) , increased pHa ( 7 . 481 to 7 . 608 ) and diminished the [ OH - ] / [ H + ] ratio , but had no significant effect on [ SID ] or [ Atot ] , although both total phosphorus [ PT ] and inorganic phosphate [ Pi ] increased .", + "entities": [] + }, + { + "id": "11769", + "type": "gene", + "text": "EEA1 is a conserved alpha - helical peripheral membrane protein flanked by cysteine \" fingers \" and contains a calmodulin - binding IQ motif .", + "entities": [ + "EEA1", + "calmodulin - binding IQ motif" + ] + }, + { + "id": "11770", + "type": "gene", + "text": "The husband in one of the married couples was treated for hepatitis of unidentified etiology in an Infectology Department four years ago .", + "entities": [] + }, + { + "id": "11771", + "type": "gene", + "text": "As authorized by the World Health Organization 29th Expert Committee on Biological Standardization , the preparation of human prolactin in ampoules coded 75 / 504 has been established as the International Reference Preparation ( IRP ) of human prolactin for immunoassay .", + "entities": [ + "human prolactin", + "human prolactin" + ] + }, + { + "id": "11772", + "type": "gene", + "text": "We investigated the incidence of congenital color deficiency among Koreans by the use of H - R - R pseudoisochromatic plates .", + "entities": [] + }, + { + "id": "11773", + "type": "gene", + "text": "The C terminus of TRBP binds to CBP / p300 and DRIP130 , a component of the DRIP / TRAP / ARC complex , which suggests that TRBP may activate transcription by means of such interactions .", + "entities": [ + "TRBP", + "CBP", + "p300", + "DRIP130", + "DRIP", + "TRAP", + "ARC", + "TRBP" + ] + }, + { + "id": "11774", + "type": "gene", + "text": "Data management in practice - based research .", + "entities": [] + }, + { + "id": "11775", + "type": "gene", + "text": "The system , designed to exploit the relatively constant small intestine transit time , consists of a drug - containing core coated with a polymeric matrix formed by a channeling agent ( NaCl , mannitol , and Emdex ) and an inert polymer ( Eudragit RS100 ) .", + "entities": [] + }, + { + "id": "11776", + "type": "gene", + "text": "Conservative treatment of central nervous system injuries", + "entities": [] + }, + { + "id": "11777", + "type": "gene", + "text": "Most recently , the use of the product of brain weight and clearance has been proposed .", + "entities": [] + }, + { + "id": "11778", + "type": "gene", + "text": "We constructed a yeast reporter strain containing the lacZ gene under the control of the CYC1 promoter associated with three copies of TRE - 1 .", + "entities": [ + "lacZ gene", + "CYC1 promoter", + "TRE - 1" + ] + }, + { + "id": "11779", + "type": "gene", + "text": "An RNA - binding protein gene ( rbp1 ) from Drosophila melanogaster , encoding an RNA recognition motif and an Arg - Ser rich ( RS ) domain , has been characterized .", + "entities": [ + "RNA - binding protein gene", + "rbp1" + ] + }, + { + "id": "11780", + "type": "gene", + "text": "In the Arithmetic subtest one of the items would not meet the difficulty grading shown while the last two items offer very little possibility of success for all subjects . ( ABSTRACT TRUNCATED AT 250 WORDS )", + "entities": [] + }, + { + "id": "11781", + "type": "gene", + "text": "2 Silastic capsules , each containing 22 - 23 mg of ethinyl estradiol , were inserted subcutaneously in 5 men with benign prostatic hypertrophy .", + "entities": [] + }, + { + "id": "11782", + "type": "gene", + "text": "These viruses depend on the host cell machinery for their existence , and interference with these processes typically interferes with other important host physiology .", + "entities": [] + }, + { + "id": "11783", + "type": "gene", + "text": "It is shown that the ( G + C ) - rich element of the aldolase C promoter directs transcription in neuronal as well as in nonneuronal cells .", + "entities": [ + "aldolase C promoter" + ] + }, + { + "id": "11784", + "type": "gene", + "text": "To identify structural features of residues flanking the c - region that influence the fidelity and efficiency of signal peptidase cleavage as well as co - translational translocation , we introduced six amino acid substitutions into the COOH terminus of the hydrophobic core and seven substitutions at the NH2 terminus of the mature region ( the + 1 position ) of a model eukaryotic preprotein - human pre ( delta pro ) apoA - II .", + "entities": [ + "eukaryotic preprotein - human pre ( delta pro ) apoA - II" + ] + }, + { + "id": "11785", + "type": "gene", + "text": "A new semi - automatic method for quantifying regional cerebral uptake of 99m technetium - hexamethylpropylene amine oxime ( 99mTc - HMPAO ) was used to assess single photon emission tomograms from 5 normal subjects , 14 patients with Alzheimer ' s disease , 14 patients with dementia of frontal lobe type and 4 patients with dementia with motor neurone disease .", + "entities": [] + }, + { + "id": "11786", + "type": "gene", + "text": "Eight hr of acidosis caused a significant ( P less than 0 . 01 ) decrease in P50 in vitro which fell from 29 . 0 to 24 . 4 torr .", + "entities": [] + }, + { + "id": "11787", + "type": "gene", + "text": "Of the drugs orally administered , WR - 168643 was the best protector with a DMF of 1 . 51 .", + "entities": [] + }, + { + "id": "11788", + "type": "gene", + "text": "Acute pancreatitis is a rather common abdominal disorder .", + "entities": [] + }, + { + "id": "11789", + "type": "gene", + "text": "In this study , we demonstrate that BOX DNA enhances transcription from the thymidine kinase ( TK ) promoter in various EC cells .", + "entities": [ + "thymidine kinase", + "TK" + ] + }, + { + "id": "11790", + "type": "gene", + "text": "Two activities of the D protein of the miniF plasmid have been found .", + "entities": [ + "D protein" + ] + }, + { + "id": "11791", + "type": "gene", + "text": "Elevated expression of full - length UhpB or of a soluble hybrid protein , GST - Bc , which is glutathione S - transferase ( GST ) fused to the cytoplasmic C - terminal portion of UhpB , results in complete blockage of uhpT expression in a uhp ( + ) strain .", + "entities": [ + "full - length UhpB", + "GST", + "Bc", + "glutathione S - transferase", + "GST", + "UhpB", + "uhpT", + "uhp ( + )" + ] + }, + { + "id": "11792", + "type": "gene", + "text": "The sequence of four clones was sufficient to construct a 3018 - bp BAL cDNA structure .", + "entities": [ + "3018 - bp BAL cDNA" + ] + }, + { + "id": "11793", + "type": "gene", + "text": "New techniques for the mass spectrometry of natural products .", + "entities": [] + }, + { + "id": "11794", + "type": "gene", + "text": "In the local geomagnetic field , the animals preferred the SE - sector .", + "entities": [] + }, + { + "id": "11795", + "type": "gene", + "text": "Sequence of 10q24 locus surrounding the HOX11 oncogene reveals a new gene HUG1 expressed in a T - ALL cell line .", + "entities": [ + "10q24 locus", + "HOX11 oncogene", + "HUG1" + ] + }, + { + "id": "11796", + "type": "gene", + "text": "We have determined that these nicks occur in both the wild - type and the mutant sites .", + "entities": [] + }, + { + "id": "11797", + "type": "gene", + "text": "Furthermore , RING1 overexpression results in enhanced expression of the proto - oncogenes c - jun and c - fos .", + "entities": [ + "RING1", + "c - jun", + "c - fos" + ] + }, + { + "id": "11798", + "type": "gene", + "text": "In B cells , HEF1 is phosphorylated by a cytoskeleton - dependent mechanism that is triggered by integrin ligation .", + "entities": [ + "HEF1", + "integrin" + ] + }, + { + "id": "11799", + "type": "gene", + "text": "Labile LTR - binding proteins appear to be essential for c - myc hyperexpression , since both LTR - enhanced transcription and the activities of LTR - binding proteins are specifically decreased after inhibition of protein synthesis ( A .", + "entities": [ + "LTR - binding proteins", + "c - myc", + "LTR - binding proteins" + ] + }, + { + "id": "11800", + "type": "gene", + "text": "In contrast , cotransfection of TFIIB and IRF - 1 into NIH 3T3 cells resulted in a dose - dependent repression of promoter activation which occurred in a TATA - dependent manner .", + "entities": [ + "TFIIB", + "IRF - 1" + ] + }, + { + "id": "11801", + "type": "gene", + "text": "Variations of the timing of deflections in the His bundle recordings .", + "entities": [] + }, + { + "id": "11802", + "type": "gene", + "text": "Alterations in DNase I reactivity of the GC - response element region suggest that GC receptor - GC complexes may associate , in a transient manner , with the promoter in the actively transcribing control state .", + "entities": [ + "DNase I", + "GC receptor - GC complexes" + ] + }, + { + "id": "11803", + "type": "gene", + "text": "Thus , we have produced lipoyl domain constructs that can be employed in sorting the specific roles of E2L1 and E2L2 in facilitating catalytic and regulatory processes .", + "entities": [ + "E2L1", + "E2L2" + ] + }, + { + "id": "11804", + "type": "gene", + "text": "In this study we examined hepatic stellate cell regulation of M6P / IGFIIR expression and found that M6P / IGFIIR mRNA transcript levels increased in stellate cells from rats exposed to carbon tetrachloride ( CCl4 ) , a potent fibrogenic stimulant .", + "entities": [ + "M6P", + "IGFIIR", + "M6P", + "IGFIIR" + ] + }, + { + "id": "11805", + "type": "gene", + "text": "In a country where general HIV prevalence is low , the strategy is cost - effective for location and counselling of unknowingly seropositive individuals .", + "entities": [] + }, + { + "id": "11806", + "type": "gene", + "text": "Analysis of various deletion mutants indicates that the sequence requirements for binding by QBP in vitro are indistinguishable from those necessary for Q activity in vivo , strongly suggesting that QBP is required for the function of this TATA - independent promoter .", + "entities": [ + "QBP", + "QBP" + ] + }, + { + "id": "11807", + "type": "gene", + "text": "Supplementing a soybean protein and sucrose - based diet with levels of 2 . 2 , 11 , and 55 ppm of the antibiotic , from the two sources each with two different purities , improved weight gain of chicks an average of 23 % and improved feed efficiency an average of 13 % at the higher levels ( all P less than . 01 ) .", + "entities": [] + }, + { + "id": "11808", + "type": "gene", + "text": "Current evidence for this type of DNA supercoiling - dependent transcriptional coupling , based largely on the in vivo activities of promoters contained in engineered DNA constructs , suggests that the transcription complex must be physically hindered to generate DNA supercoils and to prevent their diffusion throughout the DNA duplex .", + "entities": [] + }, + { + "id": "11809", + "type": "gene", + "text": "Semidominant mutations in the yeast Rad51 protein and their relationships with the Srs2 helicase .", + "entities": [ + "yeast Rad51 protein", + "Srs2 helicase" + ] + }, + { + "id": "11810", + "type": "gene", + "text": "Endothelial cells stored with University of Wisconsin solution excluded trypan blue better ( 1 . 0 % + / - 0 . 5 % cells stained , p less than 0 . 001 .", + "entities": [] + }, + { + "id": "11811", + "type": "gene", + "text": "Three FGF - AS cDNAs were isolated ; the full - length FGF - AS mRNA and two alternative splice variants lacking exon 2 or exons 2 and 3 of the FGF - AS sequence .", + "entities": [ + "FGF - AS cDNAs", + "full - length FGF - AS mRNA", + "FGF - AS sequence" + ] + }, + { + "id": "11812", + "type": "gene", + "text": "A fluoroimmunoassay for the determination of serum of plasma levels of propranolol was developed using antibodies to propranolol coupled to magnetizable solid - phase particles and fluorescein - labeled propranolol as tracer .", + "entities": [] + }, + { + "id": "11813", + "type": "gene", + "text": "The human CD38 gene consists of 8 exons that extend more than 77 kb on the human genome .", + "entities": [ + "human CD38 gene" + ] + }, + { + "id": "11814", + "type": "gene", + "text": "Analysis of mRNA expression shows that AT - BP1 and AT - BP2 are expressed in all the tissues examined .", + "entities": [ + "AT - BP1", + "AT - BP2" + ] + }, + { + "id": "11815", + "type": "gene", + "text": "In order to infer shape from contour , the human visual system must selectively integrate fragments projecting from a common object while keeping fragments from different objects separate .", + "entities": [] + }, + { + "id": "11816", + "type": "gene", + "text": "CD was determined using the Farnsworth D - 15 method .", + "entities": [] + }, + { + "id": "11817", + "type": "gene", + "text": "However , the a1 isoform is expressed most heavily in brain and heart , a2 in liver and kidney , and a3 in liver , lung , heart , brain , spleen , and kidney .", + "entities": [] + }, + { + "id": "11818", + "type": "gene", + "text": "The Oct and HMG2 proteins also interact in vivo .", + "entities": [ + "Oct", + "HMG2 proteins" + ] + }, + { + "id": "11819", + "type": "gene", + "text": "Gas6 contains an NH2 - terminal Gla domain followed by four epidermal growth factor - like repeats and tandem globular ( G ) domains .", + "entities": [ + "Gas6", + "epidermal growth factor - like repeats" + ] + }, + { + "id": "11820", + "type": "gene", + "text": "Men were more positive about their physical fitness than women .", + "entities": [] + }, + { + "id": "11821", + "type": "gene", + "text": "The human MSH - 2 gene product is a member of a highly conserved family of proteins which are involved in post - replication mismatch repair .", + "entities": [ + "human MSH - 2 gene product" + ] + }, + { + "id": "11822", + "type": "gene", + "text": "hMSH - 2 is homologous to Escherichia coli ( E . coli ) MutS and Sacchromyces cerevisiae MSH - 1 and MSH - 2 proteins , which recognise heteroduplex DNA at the sites of all single base mismatches and deletions or insertions up to 4 base pairs .", + "entities": [ + "hMSH - 2", + "MutS", + "Sacchromyces cerevisiae MSH - 1", + "MSH - 2 proteins" + ] + }, + { + "id": "11823", + "type": "gene", + "text": "hMSH - 2 is one of the hereditary non - polyposis colorectal cancer ( HNPCC ) tumor suppressor genes , and maps to human chromosome 2p16 .", + "entities": [ + "hMSH - 2", + "hereditary non - polyposis colorectal cancer ( HNPCC ) tumor suppressor genes" + ] + }, + { + "id": "11824", + "type": "gene", + "text": "A novel myeloid - restricted zebrafish CCAAT / enhancer - binding protein with a potent transcriptional activation domain .", + "entities": [ + "CCAAT / enhancer - binding protein" + ] + }, + { + "id": "11825", + "type": "gene", + "text": "The proteins differ in the presence or absence of a 21 - amino - acid sequence located 24 amino acids C terminal of the translational initiation codon .", + "entities": [] + }, + { + "id": "11826", + "type": "gene", + "text": "Sequencing of the facB gene revealed that it encodes a protein that contains an N - terminal GAL4 - like Zn ( II ) 2Cys6 ( or C6 zinc ) binuclear cluster for DNA binding , leucine zipper - like heptad repeat motifs and central and C - terminal acidic alpha - helical regions , consistent with a function as a DNA - binding transcriptional activator .", + "entities": [ + "facB gene", + "GAL4" + ] + }, + { + "id": "11827", + "type": "gene", + "text": "Substitution of a threonine residue by an alanine residue at position - 2 ( P2 ) of this cleavage site abolished cleavage , whereas substitution of a tyrosine residue by a phenylalanine residue at amino acid position - 1 ( P1 ) of the cleavage site did not influence processing .", + "entities": [] + }, + { + "id": "11828", + "type": "gene", + "text": "Cis - regulation downstream of cell type specification : a single compact element controls the complex expression of the CyIIa gene in sea urchin embryos .", + "entities": [ + "CyIIa gene" + ] + }, + { + "id": "11829", + "type": "gene", + "text": "Groups of ten dependent and ten saline mice were singly tested in both light and dark conditions in each of five covered cylinders ( 2 - 23 in high ) .", + "entities": [] + }, + { + "id": "11830", + "type": "gene", + "text": "Asymptomatic bacteriospermia and fertility", + "entities": [] + }, + { + "id": "11831", + "type": "gene", + "text": "5 .", + "entities": [] + }, + { + "id": "11832", + "type": "gene", + "text": "A high - frequency restriction fragment length polymorphism was evident in the DNA from 29 unrelated individuals using the enzyme BglII .", + "entities": [ + "BglII" + ] + }, + { + "id": "11833", + "type": "gene", + "text": "Our data show that multiple MLSN1 transcripts , both constitutively expressed and inducible , are present in cultured pigmented melanoma cells , and suggest that MLSN1 expression can be regulated at the level of both transcription and mRNA processing .", + "entities": [ + "MLSN1 transcripts", + "MLSN1" + ] + }, + { + "id": "11834", + "type": "gene", + "text": "We show also that RA represses the transcriptional activity of a reporter gene containing a TPA responding AP1 binding site driving the HSV tk promoter .", + "entities": [ + "AP1 binding site", + "HSV tk promoter" + ] + }, + { + "id": "11835", + "type": "gene", + "text": "The glucose / insulin stimulation was inhibited by the addition of polyunsaturated fatty acids .", + "entities": [ + "insulin" + ] + }, + { + "id": "11836", + "type": "gene", + "text": "MATERIALS AND METHODS : Coronal 3D GRE imaging was used to study the volar , middle , and dorsal portions of the SLL in 14 patients with an arthroscopically normal SLL and in five cadaveric wrists that had a normal SLL proved with dissection .", + "entities": [] + }, + { + "id": "11837", + "type": "gene", + "text": "The current study demonstrates that T3 - activated transcription of the NADPH : cytochrome P450 oxidoreductase ( P450R ) gene is dependent on the thyroid hormonal status of the animal , with both transcriptional and post - transcriptional pathways being important in regulating the cellular P450R mRNA level .", + "entities": [ + "NADPH : cytochrome P450 oxidoreductase", + "P450R", + "P450R" + ] + }, + { + "id": "11838", + "type": "gene", + "text": "The second goal was to ascertain the somatotopic arrangement of the GPi in PD .", + "entities": [] + }, + { + "id": "11839", + "type": "gene", + "text": "Moloney murine leukemia virus ( MMLV ) - derived pUCMoTiN - based retroviral vectors were engineered to allow constitutive and Tat ( trans - activator of transcription ) - inducible expression of five hammerhead ribozymes targeted against highly conserved sequences within the group antigen ( Gag ) , protease ( Pro ) , reverse transcriptase ( RT ) , tat , and envelope ( Env ) coding regions of human immunodeficiency virus type - 1 ( HIV - 1 ) RNA .", + "entities": [ + "Tat", + "trans - activator of transcription", + "group antigen", + "Gag", + "protease", + "Pro", + "reverse transcriptase", + "RT", + "tat", + "envelope", + "Env" + ] + }, + { + "id": "11840", + "type": "gene", + "text": "The intrapancreatic spread of the carcinoma correlated with portal invasion of carcinoma , hardness of the body and tail , obstruction of main pancreatic duct and irregular pancreaticogram .", + "entities": [] + }, + { + "id": "11841", + "type": "gene", + "text": "Cryopreservation straws filled with media plus additive are emersed below the surface of an unprocessed donor ejaculate .", + "entities": [] + }, + { + "id": "11842", + "type": "gene", + "text": "Although the binding of IE2 86 to nonphosphorylated full - length CREB or deltaCREB is minimal , IE2 86 does form complexes with p300 and the CREB - binding protein ( CBP ) , which in turn bind to CREB and can serve as adaptor proteins for CREB function .", + "entities": [ + "IE2 86", + "full - length CREB", + "deltaCREB", + "IE2 86", + "p300", + "CREB - binding protein", + "CBP", + "CREB", + "CREB" + ] + }, + { + "id": "11843", + "type": "gene", + "text": "G - CSF ( 480 micrograms subcutaneously ( s . c . ) ) were used in 55 and GM - CSF ( 400 micrograms s . c . ) in 28 chemotherapeutic cycles .", + "entities": [ + "G - CSF", + "GM - CSF" + ] + }, + { + "id": "11844", + "type": "gene", + "text": "Some 8 . 8 kb of the Lactobacillus sake plasmid pCIM1 was sequenced , revealing eight tightly clustered open reading frames ( ORFs ) downstream from lasA , which encodes pre - lactocin S .", + "entities": [ + "lasA", + "pre - lactocin S" + ] + }, + { + "id": "11845", + "type": "gene", + "text": "Primer extension experiments indicated that the transcription initiation site mapped to a position on gene IV that was analogous to that reported for the structurally similar P - 450e gene .", + "entities": [ + "gene IV", + "P - 450e gene" + ] + }, + { + "id": "11846", + "type": "gene", + "text": "This shows that the characteristically diffuse banding pattern of plant nuclear proteins interacting with the G - box is also observed in a binding assay using only one recombinant GBF .", + "entities": [ + "recombinant GBF" + ] + }, + { + "id": "11847", + "type": "gene", + "text": "In 1993 and 1994 and infection with body lice was registered 41 times in 31 patients at the clinic for homeless of the Community Health Service of Utrecht .", + "entities": [] + }, + { + "id": "11848", + "type": "gene", + "text": "The distributed current density J is calculated within the volume defined by the motor unit .", + "entities": [] + }, + { + "id": "11849", + "type": "gene", + "text": "To analyze the VH regions of polyreactive antibodies , with particular attention at their somatically mutated status , we generated five IgG ( three IgG1 and two IgG3 ) mAb ( using B cells from a healthy subject , a patient with insulin - dependent diabetes mellitus and a patient with SLE ) , which bound with various efficiencies a number of different self and foreign Ag .", + "entities": [ + "IgG", + "IgG1", + "IgG3", + "insulin" + ] + }, + { + "id": "11850", + "type": "gene", + "text": "We provide community metabolic data that indicate that large changes in CO2 concentration can occur in coral reef waters via biogeochemical processes not directly associated with photosynthesis , respiration , calcification , and CaCO3 dissolution .", + "entities": [] + }, + { + "id": "11851", + "type": "gene", + "text": "These lesions may be treated by propranolol or phentolamine .", + "entities": [] + }, + { + "id": "11852", + "type": "gene", + "text": "Additionally , a variety of regulatory schemes contribute temporal and / or spatial restriction to TGF - beta responses .", + "entities": [ + "TGF - beta" + ] + }, + { + "id": "11853", + "type": "gene", + "text": "The recombinant vaccinia virus - expressed mutant P1 polyproteins were analyzed for proteolytic processing defects in cells coinfected with a recombinant vaccinia virus ( VVP3 ) that expresses the poliovirus 3CD protease and for processing and assembly defects by using a trans complementation system in which P1 - expressing recombinant vaccinia viruses provide capsid precursor to a defective poliovirus genome that does not express functional capsid proteins ( D .", + "entities": [ + "recombinant vaccinia virus - expressed mutant P1 polyproteins", + "poliovirus 3CD protease", + "P1", + "capsid precursor", + "capsid proteins" + ] + }, + { + "id": "11854", + "type": "gene", + "text": "However , the lens dose ( 3 . 6 Gy / 25 fractions ) was higher compared to the other techniques .", + "entities": [] + }, + { + "id": "11855", + "type": "gene", + "text": "Proprotein processing occurs intracellularly .", + "entities": [] + }, + { + "id": "11856", + "type": "gene", + "text": "Actuarial freedom from ventricular arrhythmias at 4 - year follow - up was 74 . 1 + / - 6 . 0 % in group A vs .", + "entities": [] + }, + { + "id": "11857", + "type": "gene", + "text": "Ileal digestibilities of DM , OM , CP , total dietary fiber ( TDF ) , fat and gross energy ( GE ) were lower ( P < 0 . 05 ) for dogs fed diets containing supplemental fiber compared with dogs fed the control diet .", + "entities": [] + }, + { + "id": "11858", + "type": "gene", + "text": "Histamine reactivity was significantly reduced after the nifedipine aerosol , the geometric mean provocative concentration causing a 35 % fall in specific airway conductance , rising from 5 . 0 to 10 . 9 mg / ml of histamine ( p less than 0 . 05 ) .", + "entities": [] + }, + { + "id": "11859", + "type": "gene", + "text": "Multilayer - relaxation geometry and electronic structure of a W ( 111 ) surface .", + "entities": [] + }, + { + "id": "11860", + "type": "gene", + "text": "Characterization of a human alternatively spliced truncated reduced folate carrier increasing folate accumulation in parental leukemia cells .", + "entities": [ + "human alternatively spliced truncated reduced folate carrier" + ] + }, + { + "id": "11861", + "type": "gene", + "text": "Recently , a protein designated GF14 has been isolated that is associated with the GBF protein complex .", + "entities": [ + "GF14", + "GBF protein complex" + ] + }, + { + "id": "11862", + "type": "gene", + "text": "Coexpression of the p120 ( ctn ) protein with an N - terminal deletion , which eliminates some potential tyrosine phosphorylation sites , or the protein with a single amino acid substitution ( tyrosine at 217 to phenylalanine ) resulted in an increase in the aggregation of v - Src - transformed EL and EalphaCL cells .", + "entities": [ + "p120", + "ctn", + "v - Src" + ] + }, + { + "id": "11863", + "type": "gene", + "text": "Static lung function in puppies after pneumonectomy .", + "entities": [] + }, + { + "id": "11864", + "type": "gene", + "text": "The emerging view based on studies in yeast is that each class of snoRNPs is composed of a unique set of proteins .", + "entities": [] + }, + { + "id": "11865", + "type": "gene", + "text": "Htra2 - beta3 is developmentally regulated and expressed predominantly in brain , liver testis , and weakly in kidney .", + "entities": [ + "Htra2 - beta3" + ] + }, + { + "id": "11866", + "type": "gene", + "text": "We analyzed the P - SAECG in the time and frequency domain in 23 patients with Paf and 19 controls .", + "entities": [] + }, + { + "id": "11867", + "type": "gene", + "text": "He was administered recombinant IFN alpha - 2b under the diagnosis of chronic hepatitis C .", + "entities": [ + "recombinant IFN alpha - 2b" + ] + }, + { + "id": "11868", + "type": "gene", + "text": "We have investigated the contribution of specific TATA - binding protein ( TBP ) - TATA interactions to the promoter activity of a constitutively expressed silkworm tRNA ( C ) ( Ala ) gene and have also asked whether the lack of similar interactions accounts for the low promoter activity of a silk gland - specific tRNA ( SG ) ( Ala ) gene .", + "entities": [ + "TATA - binding protein", + "TBP", + "silkworm tRNA ( C ) ( Ala ) gene", + "silk gland - specific tRNA ( SG ) ( Ala ) gene" + ] + }, + { + "id": "11869", + "type": "gene", + "text": "Involvement of AP - 2 in regulation of the R - FABP gene in the developing chick retina .", + "entities": [ + "AP - 2", + "R - FABP gene" + ] + }, + { + "id": "11870", + "type": "gene", + "text": "A phylogenetic analysis with the TK domains from these sequences and a fourth , from a novel scavenger RTK ( all domains comprise the signature for the TK class II receptors ) , showed that they are distantly related to the insulin and insulin - like receptors .", + "entities": [ + "TK domains", + "scavenger RTK", + "TK class II receptors", + "insulin", + "insulin - like receptors" + ] + }, + { + "id": "11871", + "type": "gene", + "text": "Presently four unique variants carrying distinct GAF sequences in the N - terminal region have been identified .", + "entities": [ + "GAF sequences" + ] + }, + { + "id": "11872", + "type": "gene", + "text": "Gabapentin for opiod - related myoclonus in cancer patients .", + "entities": [] + }, + { + "id": "11873", + "type": "gene", + "text": "In the whole group , basal GH and somatomedin - C levels decreased from a mean ( + / - standard error of the mean ) of 52 . 3 + / - 12 . 7 to 11 . 1 + / - 6 . 3 ng / ml and from 7 . 6 + / - 0 . 7 to 2 . 5 + / - 0 . 5 U / ml , respectively .", + "entities": [ + "GH", + "somatomedin - C" + ] + }, + { + "id": "11874", + "type": "gene", + "text": "IL - 1beta ( 10 ng / ml ) drastically increased both PDGFalphaR and CCAAT / enhancer - binding protein delta ( C / EBPdelta ) mRNA levels in a time dependent manner .", + "entities": [ + "IL - 1beta", + "PDGFalphaR", + "CCAAT / enhancer - binding protein delta", + "C / EBPdelta" + ] + }, + { + "id": "11875", + "type": "gene", + "text": "If you think education is expensive - - try ignorance - - Bok ' s Law .", + "entities": [] + }, + { + "id": "11876", + "type": "gene", + "text": "LH / CG receptor activation of ARNO is not mediated by activation of phosphatidylinositol 3 - kinase ( PI 3 - kinase ) or by G protein beta gamma subunits .", + "entities": [ + "LH / CG receptor", + "ARNO", + "phosphatidylinositol 3 - kinase", + "PI 3 - kinase", + "G protein beta gamma subunits" + ] + }, + { + "id": "11877", + "type": "gene", + "text": "Estimated nucleic acid N absorption is 7 - 8 % of N intake .", + "entities": [] + }, + { + "id": "11878", + "type": "gene", + "text": "Resistance pattern of Mycobacterium tuberculosis ( H 37 Rv ) to a new antibiotic , lividomycin", + "entities": [] + }, + { + "id": "11879", + "type": "gene", + "text": "The skp1 + gene is not essential .", + "entities": [ + "skp1 + gene" + ] + }, + { + "id": "11880", + "type": "gene", + "text": "Complementary DNAs encompassing the coat protein coding and adjacent regions of Agropyron mosaic virus ( AgMV ) and Hordeum mosaic virus ( HoMV ) were cloned and sequenced .", + "entities": [ + "coat protein" + ] + }, + { + "id": "11881", + "type": "gene", + "text": "Several cytokines exhibit a high degree of temporal regulation as well as somnogenic potency ( e . g . , interleukin - 1 [ IL - 1 ] , tumor necrosis factor - alpha [ TNF - alpha ] ) .", + "entities": [ + "interleukin - 1", + "IL - 1", + "tumor necrosis factor - alpha", + "TNF - alpha" + ] + }, + { + "id": "11882", + "type": "gene", + "text": "Here we demonstrate that the protein product of the ref - 1 gene stimulates the DNA binding activity of Fos - Jun heterodimers , Jun - Jun homodimers and Hela cell AP - 1 proteins as well as that of several other transcription factors including NF - kappa B , Myb and members of the ATF / CREB family .", + "entities": [ + "ref - 1 gene", + "Fos", + "Jun", + "Jun", + "Jun", + "AP - 1 proteins", + "NF - kappa B", + "Myb", + "ATF", + "CREB" + ] + }, + { + "id": "11883", + "type": "gene", + "text": "The human T cell lymphotropic retrovirus type I ( HTLV - I ) trans - activator , Tax , interacts specifically with the basic - domain / leucine - zipper ( bZip ) protein , cAMP response element binding protein ( CREB ) , bound to the viral Tax - responsive element consisting of three imperfect 21 - base pair repeats , each with a cAMP response element core flanked by G / C - rich sequences .", + "entities": [ + "Tax", + "basic - domain / leucine - zipper ( bZip ) protein", + "cAMP response element binding protein", + "CREB", + "viral Tax - responsive element" + ] + }, + { + "id": "11884", + "type": "gene", + "text": "The tryptase locus also contains at least four tryptase - like pseudogenes , including mastin , a gene expressed in dogs but not in humans .", + "entities": [ + "tryptase locus", + "tryptase - like pseudogenes", + "mastin" + ] + }, + { + "id": "11885", + "type": "gene", + "text": "The highly restrained girls had a significantly higher EAT score than the low - restrained girls , and shared with their mothers a susceptibility to the disinhibitory effects of negative mood states on their eating behaviour .", + "entities": [] + }, + { + "id": "11886", + "type": "gene", + "text": "Despite these limitations the CHIME monitor provides an opportunity to record physiological data previously unavailable in the home .", + "entities": [] + }, + { + "id": "11887", + "type": "gene", + "text": "With regard to the optimal threshold values , sensitivity and specificity were 100 % / 97 % and 95 % / 95 % with FDG PET , compared to 86 % / 92 % and 77 % / 82 % with IS , respectively .", + "entities": [] + }, + { + "id": "11888", + "type": "gene", + "text": "The effects of mean luminance were also measured and a general expression that would take them into account was derived .", + "entities": [] + }, + { + "id": "11889", + "type": "gene", + "text": "RESULTS : Soluble CD23 levels were significantly higher in women with endometriosis before treatment than in ten normal controls .", + "entities": [ + "CD23" + ] + }, + { + "id": "11890", + "type": "gene", + "text": "The second class of cDNA hybridized to a 13 kb transcript , which was approximately twice as large as the mammalian lactase mRNA .", + "entities": [ + "mammalian lactase mRNA" + ] + }, + { + "id": "11891", + "type": "gene", + "text": "In contrast , c - Src - derived construct ( a - Src ) , that was excluded from detergent - resistant membranes , could not restore the series of phagocytosis signaling .", + "entities": [ + "c - Src - derived construct", + "a - Src" + ] + }, + { + "id": "11892", + "type": "gene", + "text": "These sorting nexins also associated with the long isoform of the leptin receptor but not with the short and medium isoforms .", + "entities": [ + "sorting nexins", + "leptin receptor" + ] + }, + { + "id": "11893", + "type": "gene", + "text": "The repetitive ETn ( early transposon ) family of sequences represents an active \" mobile mutagen \" in the mouse genome .", + "entities": [ + "ETn", + "early transposon" + ] + }, + { + "id": "11894", + "type": "gene", + "text": "Therefore , we studied ninety coagulopathic patients with the aim of determining the prevalence of hepatitis C virus ( HCV ) antibodies using the ELISA and RIBA methods .", + "entities": [ + "hepatitis C virus ( HCV ) antibodies" + ] + }, + { + "id": "11895", + "type": "gene", + "text": "The possible origin and role of CSF prolactin are discussed .", + "entities": [ + "CSF prolactin" + ] + }, + { + "id": "11896", + "type": "gene", + "text": "Infectious mutant virus progeny was obtained only on complementing gK - expressing cells , suggesting that gK has an important function in the replication cycle .", + "entities": [ + "gK", + "gK" + ] + }, + { + "id": "11897", + "type": "gene", + "text": "However , we did detect lot - to - lot variation and differences in performance between narrow bandpass and wide bandpass spectrophotometers .", + "entities": [] + }, + { + "id": "11898", + "type": "gene", + "text": "BCR cross - linking also led to increased MAPK - activated protein kinase - 2 activity , an enzyme that lies immediately downstream from p38 MAPK ; MAPK - activated protein kinase - 2 immune complexes phosphorylated a peptide substrate containing the CREB serine 133 phosphoacceptor motif .", + "entities": [ + "BCR", + "MAPK", + "protein kinase - 2", + "p38 MAPK", + "MAPK", + "protein kinase - 2", + "CREB serine 133 phosphoacceptor motif" + ] + }, + { + "id": "11899", + "type": "gene", + "text": "These experiments confirm that the 6 - S liganded form of the receptor identified in nuclear extracts of cells treated with 2 , 3 , 7 , 8 - tetrachlorodibenzo - p - dioxin ( TCDD ) contains the Ah receptor protein and ARNT but not the 90 - kDa heat shock protein .", + "entities": [ + "Ah receptor protein", + "ARNT", + "90 - kDa heat shock protein" + ] + }, + { + "id": "11900", + "type": "gene", + "text": "Particularly striking was the conservation of an AP - 4 binding site within 100 nucleotides upstream of the transcription initiation site in both Aal - rpL34 and Aal - rpL8 genes .", + "entities": [ + "AP - 4 binding site", + "Aal", + "rpL34", + "Aal", + "rpL8" + ] + }, + { + "id": "11901", + "type": "gene", + "text": "Despite considerable research , an explanation of this effect has been elusive .", + "entities": [] + }, + { + "id": "11902", + "type": "gene", + "text": "In the present study , we transiently expressed in primary cultures of rat hepatocytes plasmids consisting of CYP3A1 5 ' - flanking sequences fused to a chloramphenicol acetyltransferase reporter plasmid .", + "entities": [ + "CYP3A1 5 ' - flanking sequences", + "chloramphenicol acetyltransferase reporter" + ] + }, + { + "id": "11903", + "type": "gene", + "text": "Based on these results and because Cdc68 has been implicated as a regulator of chromatin structure , we postulate that polymerase alpha may interact with these proteins to gain access to its template or to origins of replication in vivo .", + "entities": [ + "Cdc68", + "polymerase alpha" + ] + }, + { + "id": "11904", + "type": "gene", + "text": "Then , pure pancreatic juice was infused into the duodenum .", + "entities": [] + }, + { + "id": "11905", + "type": "gene", + "text": "Encompassing tamponade and pericardiocentesis data , left ventricular stroke work index showed positive correlation with TMFP1 ( r = . 59 ) and TMFP2 ( r = . 52 ) but not with TMFP3 .", + "entities": [] + }, + { + "id": "11906", + "type": "gene", + "text": "Truncations composed of 78 and 64 amino acids were translocated across the endoplasmic reticulum membrane , and translocation was found to be strictly co - translational and SRP - dependent .", + "entities": [ + "SRP" + ] + }, + { + "id": "11907", + "type": "gene", + "text": "We show that cytR expression is negatively controlled by the CytR protein and positively affected by the cAMP / CAP complex .", + "entities": [ + "cytR", + "CytR protein", + "cAMP / CAP complex" + ] + }, + { + "id": "11908", + "type": "gene", + "text": "Plasmids for the cloning and expression of full - length double - stranded cDNAs under control of the SV40 early or late gene promoter .", + "entities": [ + "SV40 early", + "late gene" + ] + }, + { + "id": "11909", + "type": "gene", + "text": "We found that the 3 ' - end - adjacent sequence CA ( N ) 3 - 10AGTNNAA , conserved in plant Pol II - specific U snRNA genes , is essential for the 3 ' - end formation of U2 transcripts and , similar to the vertebrate 3 ' box , is highly tolerant to mutation .", + "entities": [ + "Pol II", + "U snRNA genes", + "U2 transcripts" + ] + }, + { + "id": "11910", + "type": "gene", + "text": "It has been shown in experiments in vitro that the hepatotrophic organic anions , the radiographic contrast agent ( RCA ) bilignost used in cholecystography and Bengal pink , have an affinity , unlike the urographic RCA triombrin and renotrophic dye indigo - carmine , for the plasmatic membranes ( PM ) of liver cells .", + "entities": [] + }, + { + "id": "11911", + "type": "gene", + "text": "Factors influencing semen characteristics in young boars reared in a subtropical environment were studied .", + "entities": [] + }, + { + "id": "11912", + "type": "gene", + "text": "Interestingly , we find that the interaction between Tat and hCycT1 requires zinc as well as essential cysteine residues in both proteins .", + "entities": [ + "Tat", + "hCycT1" + ] + }, + { + "id": "11913", + "type": "gene", + "text": "Both mutations confer amino acid substitutions in the viral coat protein but differ in their relative abilities to utilize the foreign scaffolding protein .", + "entities": [ + "viral coat protein", + "scaffolding protein" + ] + }, + { + "id": "11914", + "type": "gene", + "text": "Although the spatial and temporal variability of LDF signals evoked by cerebrocortical microflow is in the same range as with other methods and in other organs , LDF cerebrocortical mapping is restricted by the large temporal and spatial heterogeneity of the cerebrocortical vasculature .", + "entities": [] + }, + { + "id": "11915", + "type": "gene", + "text": "Statistically significant effects were noted at doses which did not appear to be maternally toxic .", + "entities": [] + }, + { + "id": "11916", + "type": "gene", + "text": "To address this issue , the gene for factor Y has been cloned molecularly and its DNA sequence has been determined .", + "entities": [ + "factor Y" + ] + }, + { + "id": "11917", + "type": "gene", + "text": "Here we demonstrate that Hh and Patched ( Ptc ) act through those Ci binding sites to modulate the level of Ci - dependent transcriptional activation in S2 cells .", + "entities": [ + "Hh", + "Patched", + "Ptc", + "Ci", + "Ci" + ] + }, + { + "id": "11918", + "type": "gene", + "text": "To investigate the convergent role of the insulin / IGF - I effector pathway mediating bihormonal stimulation of LDL receptor promoter expression , transfected granulosa - luteal cells were pretreated for 30 min with two specific inhibitors of phophatidylinositol 3 - kinase , wortmannin ( 100 nM ) and LY 294002 ( 10 microM ) , or of mitogen - activated protein kinase kinase , PD 98059 ( 50 microM ) , U0126 ( 10 microM ) , or the latter ' s inactive derivative , U0124 ( 10 microM ) .", + "entities": [ + "insulin", + "IGF - I", + "LDL receptor promoter", + "phophatidylinositol 3 - kinase", + "mitogen - activated protein kinase kinase" + ] + }, + { + "id": "11919", + "type": "gene", + "text": "We suggest that this gene cluster codes for ( parts of ) a multisubunit cytochrome c haem lyase .", + "entities": [ + "multisubunit cytochrome c haem lyase" + ] + }, + { + "id": "11920", + "type": "gene", + "text": "In sorted bone marrow cells expression of both VpreB genes was detected in pro - B / pre - BI and large pre - BII cells , while the RNA steady state levels were at least 100 - fold lower in small pre - BII and immature / mature B cells .", + "entities": [ + "VpreB genes" + ] + }, + { + "id": "11921", + "type": "gene", + "text": "High expression of the peroxisome proliferator - activated receptor alpha ( PPARalpha ) differentiates brown fat from white , and is related to its high capacity of lipid oxidation .", + "entities": [ + "peroxisome proliferator - activated receptor alpha", + "PPARalpha" + ] + }, + { + "id": "11922", + "type": "gene", + "text": "We further found that KmMig1p is fully functional when expressed in S . cerevisiae .", + "entities": [ + "KmMig1p" + ] + }, + { + "id": "11923", + "type": "gene", + "text": "The authors conclude that nonspecificity of low platelet MAO as a possible correlate of bipolar affective disorder , as well as schizophrenia , increases the burden of proof necessary before findings of low platelet MAO can be accepted as primary .", + "entities": [ + "platelet MAO", + "platelet MAO" + ] + }, + { + "id": "11924", + "type": "gene", + "text": "The diagnostic significance of creatine phosphokinase antibodies in the cardiac muscle in non - coronarogenic myocardial diseases", + "entities": [ + "creatine phosphokinase" + ] + }, + { + "id": "11925", + "type": "gene", + "text": "The modification of P32 uptake into the Jensen sarcoma in vitro by adding of peroxide to the nutritive medium", + "entities": [] + }, + { + "id": "11926", + "type": "gene", + "text": "This finding is consistent with the notion that the dsRNA binding domains may be composed of two separate functional subdomains .", + "entities": [] + }, + { + "id": "11927", + "type": "gene", + "text": "We have previously identified a liver - enriched transcription factor , HNF - 6 , which is required for HNF - 3 beta promoter activity and also recognizes the regulatory region of numerous hepatocyte - specific genes .", + "entities": [ + "HNF - 6", + "HNF - 3 beta promoter" + ] + }, + { + "id": "11928", + "type": "gene", + "text": "A - 69 - year - old patient with postoperative small - bowel obstruction underwent laparotomy three times .", + "entities": [] + }, + { + "id": "11929", + "type": "gene", + "text": "This sensitivity analysis showed that the practical limits of the accuracy of the used screening test jeopardize the estimation of the true herd prevalence within reasonable confidence limits , because the within - herd PTB true prevalence was low . For this reason we augmented the herd specificity for herds with larger adult herd size ( > 5 ) .", + "entities": [] + }, + { + "id": "11930", + "type": "gene", + "text": "Our results indicate that Shh can drive continued cycling in immature , proliferating CGNPs .", + "entities": [ + "Shh" + ] + }, + { + "id": "11931", + "type": "gene", + "text": "We determined whether regional myocardial work efficiency ( segment work / regional O2 consumption ) would be elevated by surgically - augmented inflow .", + "entities": [] + }, + { + "id": "11932", + "type": "gene", + "text": "Discrepant results with a latex agglutination test in the assessment of cytomegalovirus antibody status of cardiac transplant donors .", + "entities": [] + }, + { + "id": "11933", + "type": "gene", + "text": "We also show that zygotically activated Xretpos transcripts are restricted to ventro - posterior specific regions and induced by UV - irradiation and BMP - 4 overexpression in cycloheximide - dependent way . genesis 26 : 198 - 207 , 2000 .", + "entities": [ + "BMP - 4" + ] + }, + { + "id": "11934", + "type": "gene", + "text": "The direct effects of transmitter release were ( a ) an early fall in MAP followed by a late pressor effect ; and ( b ) an early bradycardia followed by a late tachycardia .", + "entities": [] + }, + { + "id": "11935", + "type": "gene", + "text": "Acad .", + "entities": [] + }, + { + "id": "11936", + "type": "gene", + "text": "Study of the alterations of intestinal absorption , by means of I - 131 - triolein , in the whole body irradiated rat", + "entities": [] + }, + { + "id": "11937", + "type": "gene", + "text": "NB - 506 completely inhibits the capacity of topoisomerase I to phosphorylate , in vitro , the human splicing factor 2 / alternative splicing factor ( SF2 / ASF ) .", + "entities": [ + "topoisomerase I", + "human splicing factor 2", + "alternative splicing factor", + "SF2", + "ASF" + ] + }, + { + "id": "11938", + "type": "gene", + "text": "The dominant negative mutant of SHP - 2 was found to inhibit the induction of tyrosine phosphorylation and DNA - binding activity of m - Stat5a , m - Stat5b , and the carboxyl - terminal deletion variant m - Stat5adelta749 , as well as the transactivation potential of m - Stat5a and m - Stat5b .", + "entities": [ + "SHP - 2", + "m - Stat5a", + "m - Stat5b", + "m - Stat5adelta749", + "m - Stat5a", + "m - Stat5b" + ] + }, + { + "id": "11939", + "type": "gene", + "text": "MSMS Council hears new public health director .", + "entities": [] + }, + { + "id": "11940", + "type": "gene", + "text": "During the first 3 min of recovery , plasma potassium fell rapidly in spite of nearly unchanged blood acidosis and significantly decreasing bicarbonate concentration .", + "entities": [] + }, + { + "id": "11941", + "type": "gene", + "text": "Alkoxymetgyl - 3 , 4 - dimethylpyridinium chlorides were synthetized by reacting 3 , 4 - dimethylpyridine with chloromethyl alkyl ethers , while 1 - ethyloxymethyl - 3 - alkylthiomethylimidazolium chlorides were obtained in reactions of 1 - ethyloxymethylimidazol with chloromethyl alkyl sulfides .", + "entities": [] + }, + { + "id": "11942", + "type": "gene", + "text": "The properties of the phi 29 SSB - ssDNA complex are described .", + "entities": [ + "SSB - ssDNA" + ] + }, + { + "id": "11943", + "type": "gene", + "text": "There were 35 boys and 15 girls , with a mean age of five and a half years .", + "entities": [] + }, + { + "id": "11944", + "type": "gene", + "text": "Oligonucleotide mutagenesis of these binding domains indicated their importance in the transcriptional regulation of the E3 promoter in yeast cells .", + "entities": [ + "E3 promoter" + ] + }, + { + "id": "11945", + "type": "gene", + "text": "Routine blood examination showed leukocytosis , thrombocytopenia , positive CRP , and elevated myocardial enzymes .", + "entities": [ + "CRP" + ] + }, + { + "id": "11946", + "type": "gene", + "text": "If E . coli is present in any source water sample , the borehole and any directly connected borehole should be embargoed .", + "entities": [] + }, + { + "id": "11947", + "type": "gene", + "text": "A 215 - base - pair ( bp ) region of the mouse MOPC 41 kappa light - chain immunoglobulin gene enhancer has been analyzed for specific binding of lymphoid and nonlymphoid nuclear factors .", + "entities": [ + "mouse MOPC 41 kappa light - chain immunoglobulin gene enhancer" + ] + }, + { + "id": "11948", + "type": "gene", + "text": "There are two immunogenic sites on the type A influenza A / Japan / 57 ( H2N2 ) hemagglutinin ( HA ) that can be recognized by class I major histocompatibility complex ( MHC ) , H - 2Kd - restricted cytolytic T lymphocytes ( CTLs ) .", + "entities": [ + "hemagglutinin", + "HA", + "class I major histocompatibility complex", + "MHC", + "H - 2Kd" + ] + }, + { + "id": "11949", + "type": "gene", + "text": "Therefore , in conjunction with a positive pregnancy test and the patient ' s clinical history , a severely depressed or absent serum PAPP - A level may aid in the diagnosis of extrauterine pregnancy .", + "entities": [ + "PAPP - A" + ] + }, + { + "id": "11950", + "type": "gene", + "text": "In line with the small values for QS / QC , our results further indicate that even large , well - perfused , occluded air spaces in the lung will hardly affect the recovered ventilation / perfusion distribution obtained from inert gas data when CDCSF6 exceeds 0 . 1 ml . min - 1 . mmHg - 1 .", + "entities": [] + }, + { + "id": "11951", + "type": "gene", + "text": "The limits of agreement between DBS and TOF responses were so wide that they cannot be used interchangeably .", + "entities": [] + }, + { + "id": "11952", + "type": "gene", + "text": "The micromethod uses microcuvettes and substitutes ferrozine for the bathophenanthroline chromogen of the ICSH .", + "entities": [] + }, + { + "id": "11953", + "type": "gene", + "text": "The BFA System reads a text file with flows , measured with fluorescent microsphere technique , and constructs the lung anatomy with volumetric pixels showing the flows with a color schema .", + "entities": [] + }, + { + "id": "11954", + "type": "gene", + "text": "Clinico - physiological experiment", + "entities": [] + }, + { + "id": "11955", + "type": "gene", + "text": "The N1 and P2 were comparable in amplitude and both had prolonged refractory periods .", + "entities": [] + }, + { + "id": "11956", + "type": "gene", + "text": "Calcinosis cutis following intravenous infusion of calcium gluconate .", + "entities": [] + }, + { + "id": "11957", + "type": "gene", + "text": "No dominant clinical factor of risk was found , but multiple regression analysis identified age , body surface area , valve size , shop order fracture rate , and manufacturing period as risk factors for OSF .", + "entities": [] + }, + { + "id": "11958", + "type": "gene", + "text": "These results indicate that the effect of the isomers of pentobarbital and secobarbital on mult FR30 FI600 responding and on suppressed responding are qualitatively similar . ( ABSTRACT TRUNCATED AT 250 WORDS )", + "entities": [] + }, + { + "id": "11959", + "type": "gene", + "text": "MutY is an adenine - DNA glycosylase with specificity for mismatches involving 8 - oxoguanine ( oG . A ) or guanine ( G . A ) .", + "entities": [ + "MutY", + "adenine - DNA glycosylase" + ] + }, + { + "id": "11960", + "type": "gene", + "text": "Kss1 binds specifically to a GST - Dig1 fusion in the absence of any other yeast protein .", + "entities": [ + "Kss1", + "GST", + "Dig1" + ] + }, + { + "id": "11961", + "type": "gene", + "text": "Also , the deduced amino acids of the antigenic regions A , B and C of VP7 were nearly conserved within the phylogenetic lineages .", + "entities": [ + "antigenic regions A , B and C of VP7" + ] + }, + { + "id": "11962", + "type": "gene", + "text": "Furthermore , early - and late - firing origins differ not in the timing of their recruitment of an Mcm protein , but in the timing of RPA ' s recruitment .", + "entities": [ + "Mcm protein", + "RPA ' s" + ] + }, + { + "id": "11963", + "type": "gene", + "text": "These results show that Ski is a component of the HDAC complex and that Ski is required for the transcriptional repression mediated by this complex .", + "entities": [ + "Ski", + "HDAC complex", + "Ski" + ] + }, + { + "id": "11964", + "type": "gene", + "text": "We have generated various base substitutions and internal deletions in and around DRE ( nucleotide positions - 93 to - 100 with respect to the transcription initiation site ) of the PCNA gene in vitro and subsequently examined their effects on the binding to DREF ( DRE - binding factor ) and PCNA gene promote activity in cultured Drosophila Kc cells as well as in living flies .", + "entities": [ + "PCNA gene", + "DREF", + "DRE - binding factor", + "PCNA gene" + ] + }, + { + "id": "11965", + "type": "gene", + "text": "We report here that out of the major pro - inflammatory cytokines examined , IL - 1alpha , IL - 1beta , TNF - alpha and IL - 6 , only IL - 6 was generated and secreted in PKCeta - expressing cells without any additional inducer in serum - supplemented cultures ( 10 % FCS ) .", + "entities": [ + "IL - 1alpha", + "IL - 1beta", + "TNF - alpha", + "IL - 6", + "IL - 6", + "PKCeta" + ] + }, + { + "id": "11966", + "type": "gene", + "text": "CYC2 encodes a 24 - kDa protein that has sequence identity to the Neurospora crassa PREG1 and the S . cerevisiae PHO80 cyclin .", + "entities": [ + "CYC2", + "Neurospora crassa PREG1", + "S . cerevisiae PHO80 cyclin" + ] + }, + { + "id": "11967", + "type": "gene", + "text": "DtxR is an iron - dependent sequence - specific DNA - binding protein that binds to the tox operator , an inverted - repeat nucleotide sequence located upstream from the diphtheria toxin gene .", + "entities": [ + "DtxR", + "tox operator", + "diphtheria toxin gene" + ] + }, + { + "id": "11968", + "type": "gene", + "text": "After MOPP therapy , complete remission of Hodgkin ' s disease was accompanied by normalization of the glucocerebrosidase level and disappearance of Gaucher ' s cells .", + "entities": [ + "glucocerebrosidase" + ] + }, + { + "id": "11969", + "type": "gene", + "text": "Acute appearance of hemiparesis or hemiplegia with initial marked spasticity was observed in 8 stroke patients .", + "entities": [] + }, + { + "id": "11970", + "type": "gene", + "text": "Remarkably , a construct corresponding to residues 631 to 970 , which contains only the LXXLL motifs and the AD1 region of SRC1 , retained strong coactivator activity in our assays .", + "entities": [ + "SRC1" + ] + }, + { + "id": "11971", + "type": "gene", + "text": "Sputum IL - 8 and MPO were significantly increased after BPT in both TDI - and grain dust - asthma ( P < 0 . 05 ) .", + "entities": [ + "Sputum IL - 8", + "MPO" + ] + }, + { + "id": "11972", + "type": "gene", + "text": "In 14 of 21 infant hearts ( 66 % ) with aortic arch interruption between the left common carotid and left subclavian arteries ( type B of Celoria and Patton ) , the right subclavian artery ( SA ) arose anomalously .", + "entities": [] + }, + { + "id": "11973", + "type": "gene", + "text": "The missing 5 ' sequences were obtained by 5 ' - rapid amplification of cDNA ends and by analysis of an NHE5 genomic clone , and the missing 3 ' sequences were obtained by 3 ' - rapid amplification of cDNA ends .", + "entities": [ + "NHE5 genomic clone" + ] + }, + { + "id": "11974", + "type": "gene", + "text": "Cdk2 and MAPK precipitates from untreated tumor lysates phosphorylated recombinant wild - type p27 but not the T187A mutant in vitro .", + "entities": [ + "Cdk2", + "MAPK", + "recombinant wild - type p27" + ] + }, + { + "id": "11975", + "type": "gene", + "text": "Furthermore , the UvrA protein interacts with the UvrB protein to modulate its activities , both in solution and in association with DNA , where the UvrAB complex possesses a helicase activity .", + "entities": [ + "UvrA protein", + "UvrB protein", + "UvrAB complex", + "helicase" + ] + }, + { + "id": "11976", + "type": "gene", + "text": "SIT ( SHP2 - interacting transmembrane adaptor protein ) is a recently identified transmembrane adaptor protein , which is expressed in lymphocytes .", + "entities": [ + "SIT", + "SHP2 - interacting transmembrane adaptor protein" + ] + }, + { + "id": "11977", + "type": "gene", + "text": "In PC12 cells , nerve growth factor induces neuronal differentiation and repressed expression of nrg - 1 .", + "entities": [ + "nerve growth factor", + "nrg - 1" + ] + }, + { + "id": "11978", + "type": "gene", + "text": "DNA sequence analysis revealed that these clones encode two distinct forms of translocase .", + "entities": [ + "translocase" + ] + }, + { + "id": "11979", + "type": "gene", + "text": "The median age was 33 years ( range 17 - 56 years ) .", + "entities": [] + }, + { + "id": "11980", + "type": "gene", + "text": "Five of the PDP1 isoforms differ by the substitution or insertion of amino acids at or near the N - terminal of the protein .", + "entities": [ + "PDP1 isoforms" + ] + }, + { + "id": "11981", + "type": "gene", + "text": "These primers yielded a PCR product of a characteristic length within most Xanthomonas species and pathovars tested .", + "entities": [] + }, + { + "id": "11982", + "type": "gene", + "text": "Using a 3 ' - rapid amplification of cDNA ends strategy , we have cloned cDNAs representing the 3 ' - termini of both the native and mutant transcripts from both P388 / ADR / 3 and P388 / ADR / 7 cells .", + "entities": [] + }, + { + "id": "11983", + "type": "gene", + "text": "BACKGROUND : Chronic alcohol consumption has been demonstrated to be deleterious to bone health .", + "entities": [] + }, + { + "id": "11984", + "type": "gene", + "text": "The subunit - a gene is preceded by a gene coding for a small hydrophobic protein , as has been observed previously in the atp operons in E . coli , bacterium PS3 and cyanobacteria .", + "entities": [ + "subunit - a gene", + "atp operons" + ] + }, + { + "id": "11985", + "type": "gene", + "text": "These results demonstrate that sequences in the SH2 / SH3 / SH2 region of p120 GAP are required for full catalytic activity toward Ras .", + "entities": [ + "SH2", + "SH3", + "SH2", + "GAP", + "Ras" + ] + }, + { + "id": "11986", + "type": "gene", + "text": "The range of 200 000 - 300 000 spermatozoa / microl appeared to be a reasonable compromise for both criteria .", + "entities": [] + }, + { + "id": "11987", + "type": "gene", + "text": "The effect of a tissue emulsion , vitamin A and nonspecific gamma - globulin on the blood clearance in rabbits", + "entities": [ + "gamma - globulin" + ] + }, + { + "id": "11988", + "type": "gene", + "text": "After 4 h , lesions in the secretory part of the stomach were scored and mucosal prostaglandin E2 synthesis was determined by the ex vivo prostaglandin generation technique .", + "entities": [] + }, + { + "id": "11989", + "type": "gene", + "text": "Peripheral and preemptive opioid antinociception in a mouse visceral pain model .", + "entities": [] + }, + { + "id": "11990", + "type": "gene", + "text": "Current status and future perspectives", + "entities": [] + }, + { + "id": "11991", + "type": "gene", + "text": "Therapeutic use of cannabis .", + "entities": [] + }, + { + "id": "11992", + "type": "gene", + "text": "Further experiments will be required to highlight the in vivo role of ELE1 in nuclear receptor functioning .", + "entities": [ + "ELE1" + ] + }, + { + "id": "11993", + "type": "gene", + "text": "In early Xenopus embryos , the transforming growth factor - beta member activin induces the gene Mix . 2 by stimulating the formation of a multiprotein complex , activin - responsive factor ( ARF ) .", + "entities": [ + "transforming growth factor - beta", + "activin", + "gene Mix . 2", + "activin - responsive factor", + "ARF" + ] + }, + { + "id": "11994", + "type": "gene", + "text": "The first 146 consecutive patients treated with EVL during the period from August , 1986 to July , 1989 are reported .", + "entities": [] + }, + { + "id": "11995", + "type": "gene", + "text": "DNA recognition by F factor TraI36 : highly sequence - specific binding of single - stranded DNA .", + "entities": [ + "TraI36" + ] + }, + { + "id": "11996", + "type": "gene", + "text": "HEED was found to bind to MA protein in vitro , as efficiently as in vivo in yeast cells .", + "entities": [ + "HEED", + "MA protein" + ] + }, + { + "id": "11997", + "type": "gene", + "text": "Our results suggest that the central role of the Notch - CBF1 / RBP - Jkappa signaling pathway in cell fate decisions renders it susceptible to pathways of viral replication and oncogenic conversion .", + "entities": [ + "Notch", + "CBF1", + "RBP - Jkappa" + ] + }, + { + "id": "11998", + "type": "gene", + "text": "The transforming protein of Rous sarcoma virus , pp60v - src , and its normal cellular homolog , pp60c - src , differ not only in oncogenic potential but also in their subcellular localization and cytoskeletal binding ability .", + "entities": [ + "pp60v - src", + "pp60c - src" + ] + }, + { + "id": "11999", + "type": "gene", + "text": "pp60v - src has been shown to stably associate with a detergent - insoluble cytoskeletal matrix , whereas pp60c - src does not .", + "entities": [ + "pp60v - src", + "pp60c - src" + ] + }, + { + "id": "12000", + "type": "gene", + "text": "2 : 121 - 133 , 1988 ) .", + "entities": [] + }, + { + "id": "12001", + "type": "gene", + "text": "Fragments containing the 21 - base - pair repeat region , the enhancer of simian virus 40 or both strongly stimulated beta - galactosidase synthesis , and three fragments from the polyomavirus enhancer region stimulated moderate levels .", + "entities": [ + "enhancer of simian virus 40", + "beta - galactosidase", + "polyomavirus enhancer region" + ] + }, + { + "id": "12002", + "type": "gene", + "text": "DESIGN - - A randomised study was conducted in all women aged 50 - 70 years who were eligible for breast cancer screening and living in the city of Utrecht .", + "entities": [] + }, + { + "id": "12003", + "type": "gene", + "text": "This was obtained with the thermal neutron fluency 2 . 0 x 10 ( 10 ) n / cm2 .", + "entities": [] + }, + { + "id": "12004", + "type": "gene", + "text": "Clinical studies SY5555 was administered to 45 patients with various infectious diseases ( 2 with acute pharyngitis , 8 with acute tonsillitis , 4 with lacunar tonsillitis , 3 each with acute bronchitis , pneumonia and pertussis , 7 with scarlet fever , 3 with impetigo contagiosa , 6 with acute urinary tract infections , 2 with balanoposthitis and 1 each with cervical lymphadenitis , S . S . S . S . , vulvitis and acute colitis ) at daily doses between 3 . 4 - 10 mg / kg , t . i . d . , for 3 - 14 days .", + "entities": [] + }, + { + "id": "12005", + "type": "gene", + "text": "Induction of Jurkat leukemic T cells with phorbol 12 - myristate 13 - acetate and ionomycin did not affect the level of FKBP mRNA .", + "entities": [ + "FKBP mRNA" + ] + }, + { + "id": "12006", + "type": "gene", + "text": "A patient matches a PIC patient if both have the same mechanism of injury , the same coding of Revised Trauma Score variables ( Glascow Coma Scale score , systolic blood pressure , respiratory rate ) , the same coded age per A Severity Characterization of Trauma ) ( ASCOT ) , and if they differ by no more than 0 . 5 for A , B , and C ( the ASCOT components for serious injuries ) .", + "entities": [] + }, + { + "id": "12007", + "type": "gene", + "text": "This constitutes evidence for an in vivo role of SRC - 1 in dimerization - induced activation by OR1 / RXRalpha .", + "entities": [ + "SRC - 1", + "OR1", + "RXRalpha" + ] + }, + { + "id": "12008", + "type": "gene", + "text": "Demographic characteristics and risk factor data for 76 , 672 clients were studied to characterize the distribution of infection with human immunodeficiency virus ( HIV ) and the use of counseling and testing facilities in Houston , Tex .", + "entities": [] + }, + { + "id": "12009", + "type": "gene", + "text": "To study the regulation of its expression , the human aldehyde reductase gene and promoter were cloned and characterized .", + "entities": [ + "human aldehyde reductase gene" + ] + }, + { + "id": "12010", + "type": "gene", + "text": "In conclusion , our data do not support a role for IVIg in the remyelination of stable multiple sclerosis lesions as measured by central conduction time .", + "entities": [ + "IVIg" + ] + }, + { + "id": "12011", + "type": "gene", + "text": "We present evidence that the upstream open reading frame ( uORF ) represses the translation of the downstream major open reading frame ( mORF ) .", + "entities": [] + }, + { + "id": "12012", + "type": "gene", + "text": "When vascular pressure ( Pvas ) was raised abruptly from - 5 to + 25 cmH2O by air inflation for 60 min , Px ( f ) became abruptly less negative , then remained stable .", + "entities": [] + }, + { + "id": "12013", + "type": "gene", + "text": "Thirty of the clones contained a complete 340 base - pair dimer unit of the repeat .", + "entities": [] + }, + { + "id": "12014", + "type": "gene", + "text": "In this animal , infected with what was judged previously to be the less virulent of the two T . cruzi stocks used ( ' strain 7 ' ) , there was severe myocarditis , with myofibre degeneration , and lesions of the oesophagus .", + "entities": [] + }, + { + "id": "12015", + "type": "gene", + "text": "The effect of smoking was not examined in this study , as such data were not available .", + "entities": [] + }, + { + "id": "12016", + "type": "gene", + "text": "The motility of sperm , except for those adjacent to both electrodes , did not change after stimulation for 60s , despite a high electrical energy .", + "entities": [] + }, + { + "id": "12017", + "type": "gene", + "text": "We have tested the function of two potential NF - kappaB - like sites present in the PAI - 2 proximal promoter for responsiveness to TNFalpha using chloramphenicol acetyl transferase reporter gene deletion and mutation analyses .", + "entities": [ + "NF - kappaB - like sites", + "PAI - 2 proximal promoter", + "TNFalpha", + "chloramphenicol acetyl transferase reporter gene" + ] + }, + { + "id": "12018", + "type": "gene", + "text": "VII .", + "entities": [] + }, + { + "id": "12019", + "type": "gene", + "text": "Our findings suggest that striatal FDG and particularly RACLO are sensitive and effective measures of striatal function and may help characterizing patients with multiple system atrophy .", + "entities": [] + }, + { + "id": "12020", + "type": "gene", + "text": "Our previous studies have shown that SHP - 1 , a SH2 domain - containing protein - tyrosine phosphatase , is expressed not only in cells of hematopoietic lineages , but also in many non - hematopoietic cells under the control of an alternative tissue - specific promoter , P1 .", + "entities": [ + "SHP - 1", + "SH2 domain - containing protein - tyrosine phosphatase" + ] + }, + { + "id": "12021", + "type": "gene", + "text": "Both genes comprise three exons , two introns and an unusually long 3 ' - untranslated region ( 3 . 2 kilobase pairs ) , specificying a mRNA of approximately 4 . 1 kilobases .", + "entities": [] + }, + { + "id": "12022", + "type": "gene", + "text": "Pediatric medical emergencies in a regional hospital : appropriate locale ?", + "entities": [] + }, + { + "id": "12023", + "type": "gene", + "text": "POU - domain proteins , such as the pituitary - specific factor Pit - 1 , are members of the homeodomain family of proteins which are important in development and homeostasis , acting constitutively or in response to signal - transduction pathways to either repress or activate the expression of specific genes .", + "entities": [ + "POU - domain proteins", + "pituitary - specific factor Pit - 1", + "homeodomain family" + ] + }, + { + "id": "12024", + "type": "gene", + "text": "This two - helix motif is thought to be involved in specific DNA sequence recognition by CAP .", + "entities": [ + "CAP" + ] + }, + { + "id": "12025", + "type": "gene", + "text": "Furthermore , upstream insertion of the GSTP1 silencer element failed to inhibit activity of a heterologous promoter in MCF7 cells .", + "entities": [ + "GSTP1 silencer element" + ] + }, + { + "id": "12026", + "type": "gene", + "text": "Effects of prostaglandin inhibitors on the onset of proteinuria and stroke in stroke - prone spontaneously hypertensive rats .", + "entities": [] + }, + { + "id": "12027", + "type": "gene", + "text": "Here , we describe a tyrosine - phosphorylated nuclear protein , YT521 - B , and show that it interacts with the nuclear transcriptosomal component scaffold attachment factor B , and the 68 - kDa Src substrate associated during mitosis , Sam68 .", + "entities": [ + "YT521 - B", + "nuclear transcriptosomal component scaffold attachment factor B", + "68 - kDa Src", + "Sam68" + ] + }, + { + "id": "12028", + "type": "gene", + "text": "Detection of airborne Mycobacterium tuberculosis by air filtration and polymerase chain reaction .", + "entities": [] + }, + { + "id": "12029", + "type": "gene", + "text": "The loss of avirulence activity because of mutations in the acidic transcriptional activation domain was restored by addition of the activation domain from the herpes simplex viral protein VP16 .", + "entities": [ + "herpes simplex viral protein VP16" + ] + }, + { + "id": "12030", + "type": "gene", + "text": "Reverse transcriptase - polymerase chain reaction assays showed that PKRDeltaE7 is expressed in a broad range of human tissues at variable levels .", + "entities": [ + "Reverse transcriptase", + "PKRDeltaE7" + ] + }, + { + "id": "12031", + "type": "gene", + "text": "Interestingly , a portion of the tail domain ( aa , 1 , 094 - 1 , 830 ) shares 58 % amino acid sequence identity with a 723 - aa protein from mouse brain reported to be a glutamic acid decarboxylase .", + "entities": [ + "glutamic acid decarboxylase" + ] + }, + { + "id": "12032", + "type": "gene", + "text": "Stimulation of macrophage function by killed Bordetella pertussis cells did not show any beneficial effect as an increased susceptibility became apparent .", + "entities": [] + }, + { + "id": "12033", + "type": "gene", + "text": "In this report this technique was applied to human breast carcinoma MDA - MB231 cells overexpressing human MPG in order to assess whether up - regulation of the initial step in BER alters the activity of selected other BER ( hOGG1 and APE / ref - 1 ) or direct reversal ( MGMT ) repair activities .", + "entities": [ + "human MPG", + "hOGG1", + "APE", + "ref - 1", + "MGMT" + ] + }, + { + "id": "12034", + "type": "gene", + "text": "The HOI induced a nearly fourfold increase in ANF in the elderly , whereas that for the young was threefold .", + "entities": [ + "ANF" + ] + }, + { + "id": "12035", + "type": "gene", + "text": "OBJECTIVE : To compare pregnancy complications in women having genetic amniocentesis at 11 - 14 weeks versus those undergoing amniocentesis at 16 - 19 weeks ' gestation .", + "entities": [] + }, + { + "id": "12036", + "type": "gene", + "text": "Expression and regulation by interferon of a double - stranded - RNA - specific adenosine deaminase from human cells : evidence for two forms of the deaminase .", + "entities": [ + "interferon", + "double - stranded - RNA - specific adenosine deaminase" + ] + }, + { + "id": "12037", + "type": "gene", + "text": "Both the presence of arginine and anaerobiosis are needed to trigger induction of the pathway .", + "entities": [] + }, + { + "id": "12038", + "type": "gene", + "text": "Transfection experiments demonstrated that the 5 ' - flanking region ( - 1894 to + 37 ) of the mStaf gene drives transcription in mouse NMuMG cells and that a construct containing a fragment from - 387 to + 37 showed the highest transcriptional activity .", + "entities": [ + "mStaf gene" + ] + }, + { + "id": "12039", + "type": "gene", + "text": "Substitutions in the YFV Ag - binding region ( ABR ) occur at four of the eight highly conserved residues that are essential for binding of peptide - Ag in the class Ia molecules .", + "entities": [ + "Ag - binding region", + "ABR" + ] + }, + { + "id": "12040", + "type": "gene", + "text": "METHODS : 93 female and 43 male patients undergoing thyroid surgery were stratified according to gender and then randomised to receive double - blind one of four antiemetic regimes : 50 mg dolasetron given orally 45 minutes prior to induction of anaesthesia ( group I ) , 12 . 5 mg dolasetron given intravenously during induction of anaesthesia ( group II ) , 1 . 25 mg DHB given intravenously during induction of anaesthesia ( group III ) or placebo ( group IV ) .", + "entities": [ + "DHB" + ] + }, + { + "id": "12041", + "type": "gene", + "text": "A genetic system was devised to select for pi protein mutants which discriminate between IR and DR ( York et al . , Gene ( Amst . ) 116 , 7 - 12 , 1992 ; York and Filutowicz , J .", + "entities": [ + "pi protein mutants" + ] + }, + { + "id": "12042", + "type": "gene", + "text": "Photopic spectral sensitivity determined electroretinographically for the pigeon eye .", + "entities": [] + }, + { + "id": "12043", + "type": "gene", + "text": "Overexpression of EFG1 in C . albicans leads to enhanced filamentous growth in the form of extended pseudohyphae in liquid and on solid media .", + "entities": [ + "EFG1" + ] + }, + { + "id": "12044", + "type": "gene", + "text": "Our analysis suggests that Upf1p is a multifunctional protein with separable activities that can affect mRNA turnover and nonsense suppression .", + "entities": [ + "Upf1p" + ] + }, + { + "id": "12045", + "type": "gene", + "text": "All of the newly acquired proviruses identified in mosaic founder SWR / J - RF / J mice that could be transmitted through the germ line were also present in somatic tissues , demonstrating that viral integration occurred before the germ line was set aside from the somatic lineages .", + "entities": [] + }, + { + "id": "12046", + "type": "gene", + "text": "These studies indicate that the acidimetric test was less sensitive than the chromogenic cephalosporin substrates and that nitrocefin and S1 could be used to screen for beta - lactamase production in these tested species .", + "entities": [ + "beta - lactamase" + ] + }, + { + "id": "12047", + "type": "gene", + "text": "Given its relative longevity on the Web , TIE researchers have been in a unique position to observe trends in telemedicine .", + "entities": [] + }, + { + "id": "12048", + "type": "gene", + "text": "A convenient measure of this impairment may be obtained using the ratio of urine volume ( V ) divided by lithium clearance ( CLi ) .", + "entities": [] + }, + { + "id": "12049", + "type": "gene", + "text": "Radioimmunoassay of serum creatine kinase B isoenzyme in the diagnosis of acute myocardial infarction .", + "entities": [ + "creatine kinase B isoenzyme" + ] + }, + { + "id": "12050", + "type": "gene", + "text": "Six putative MDV genome products , including one Rep and five non - Rep proteins , show high ( 70 . 4 - 90 . 9 % ) amino acid identity to the corresponding six FBNYV proteins , whereas two other Rep proteins encoded by MDV - C2 and C3 are 82 . 3 % and 73 . 0 % identical to those encoded by SCSV - C2 and C6 , respectively .", + "entities": [ + "Rep", + "Rep", + "FBNYV proteins", + "Rep proteins", + "MDV - C2", + "C3", + "SCSV - C2", + "C6" + ] + }, + { + "id": "12051", + "type": "gene", + "text": "In our opinion , the SM - CMA system is , despite some shortcomings in its user - interface , a useful and versatile instrument for examination of human semen samples , with desirable features .", + "entities": [] + }, + { + "id": "12052", + "type": "gene", + "text": "Insertional inactivation of sms led to increased sensitivity to the alkylating agent methylmethane sulfonate , but not to a requirement for serine or other metabolites .", + "entities": [ + "sms" + ] + }, + { + "id": "12053", + "type": "gene", + "text": "OBJECTIVE : To demonstrate a lack of effect of steady - state concentrations of cilomilast , a new oral phosphodiesterase 4 inhibitor for the treatment of chronic obstructive pulmonary disease , on warfarin - induced anticoagulation .", + "entities": [ + "phosphodiesterase 4" + ] + }, + { + "id": "12054", + "type": "gene", + "text": "These patients appear to have slightly better pulmonary function and nutritional status ; yet , they seem to have a higher degree of health care utilization .", + "entities": [] + }, + { + "id": "12055", + "type": "gene", + "text": "The extraction was subsequently rated as ' easy ' or ' difficult ' . Taking Pell - Gregory class C as a predictor of a ' difficult ' extraction , specificity was 88 % but sensitivity was low at 15 % .", + "entities": [] + }, + { + "id": "12056", + "type": "gene", + "text": "The genome of the human herpesvirus 8 ( HHV - 8 ) contains a cluster of open reading frames ( ORFs ) encoding proteins with homology to the cellular transcription factors of the interferon regulatory factor ( IRF ) family .", + "entities": [ + "interferon regulatory factor", + "IRF" + ] + }, + { + "id": "12057", + "type": "gene", + "text": "Sodium dodecyl sulphate - induced cleavage by eukaryotic topoisomerase I is known to yield enzyme covalently attached to the 3 ' cut end of the DNA .", + "entities": [ + "eukaryotic topoisomerase I" + ] + }, + { + "id": "12058", + "type": "gene", + "text": "Several new techniques are available for monitoring control of diabetes .", + "entities": [] + }, + { + "id": "12059", + "type": "gene", + "text": "Analysis of the genome sequence revealed 26 , 588 protein - encoding transcripts for which there was strong corroborating evidence and an additional approximately 12 , 000 computationally derived genes with mouse matches or other weak supporting evidence .", + "entities": [] + }, + { + "id": "12060", + "type": "gene", + "text": "These six districts have an area of 34 , 000 km2 and hold a population of 30 million .", + "entities": [] + }, + { + "id": "12061", + "type": "gene", + "text": "While Pt ; cycH ; 1 and Os ; cycH ; 1 were expressed in all tissues examined , the transcripts accumulated abundantly in dividing cells .", + "entities": [ + "Pt ; cycH ; 1", + "Os ; cycH ; 1" + ] + }, + { + "id": "12062", + "type": "gene", + "text": "NOT4 interacts with NOT1 and NOT3 in the two - hybrid assay , and overexpression of NOT3 or NOT4 suppresses not1 and not2 mutations .", + "entities": [ + "NOT4", + "NOT1", + "NOT3", + "NOT3", + "NOT4", + "not1", + "not2" + ] + }, + { + "id": "12063", + "type": "gene", + "text": "We compared the inhibitory effect of naturally occurring mutant hTR beta 1 , artificially created hTR alpha 1 mutants , c - erbA alpha 2 and the human peroxisome proliferator - activated receptor ( hPPAR ) on three prototypic T3 - response elements ( TREs ) , TRE - PAL , DR + 4 and TRE - LAP .", + "entities": [ + "mutant hTR beta 1", + "hTR alpha 1 mutants", + "c - erbA alpha 2", + "human peroxisome proliferator - activated receptor", + "hPPAR" + ] + }, + { + "id": "12064", + "type": "gene", + "text": "A note on the phase - plane technique representation of cardiac action potentials .", + "entities": [] + }, + { + "id": "12065", + "type": "gene", + "text": "Haemodilution in cardiopulmonary bypass using a gelatine derivative for priming .", + "entities": [] + }, + { + "id": "12066", + "type": "gene", + "text": "Glomerular lesions in renal allografts .", + "entities": [] + }, + { + "id": "12067", + "type": "gene", + "text": "Optical - absorption spectra , crystal - field energy levels , and transition line strengths of holmium in trigonal Na3", + "entities": [] + }, + { + "id": "12068", + "type": "gene", + "text": "Biochemical analysis reveals that KS1 is a nuclear protein containing two transcriptional repressor domains , R1 and R2 .", + "entities": [ + "KS1" + ] + }, + { + "id": "12069", + "type": "gene", + "text": "Upstream of the dra gene an open reading frame of 313 amino acids was identified .", + "entities": [ + "dra gene" + ] + }, + { + "id": "12070", + "type": "gene", + "text": "These data suggest that a major part of the reduction in food intake in hyperphagic rats eating a quinine - adulterated diet is due to postingestional events .", + "entities": [] + }, + { + "id": "12071", + "type": "gene", + "text": "Erratum : Absence of precursor effects above the martensitic transformation in a virgin crystal of Li metal", + "entities": [] + }, + { + "id": "12072", + "type": "gene", + "text": "Current diagnostic uses of computerized tomography in clinical medicine .", + "entities": [] + }, + { + "id": "12073", + "type": "gene", + "text": "METHOD : The sample of subjects was drawn from the Suffolk County Mental Health Project , a longitudinal epidemiologic study of first - hospitalized subjects with psychotic disorders ; the present study focused on patients with schizophrenic disorders .", + "entities": [] + }, + { + "id": "12074", + "type": "gene", + "text": "Here , we show that the phorbol ester PMA decreases both basal and dexamethasone / cAMP - induced expression of a luciferase gene under the control of the G6Pase promoter in transiently transfected H4IIE hepatoma cells .", + "entities": [ + "luciferase gene", + "G6Pase promoter" + ] + }, + { + "id": "12075", + "type": "gene", + "text": "The human immunodeficiency virus type 1 ( HIV - 1 ) Rev protein is a positive posttranscriptional regulator of viral structural gene expression and essential for virus replication .", + "entities": [ + "human immunodeficiency virus type 1 ( HIV - 1 ) Rev protein" + ] + }, + { + "id": "12076", + "type": "gene", + "text": "Commercially available formulations of 2 . 5 % and 5 % lambdacyhalothrin can be diluted either with water for ULV cold aerosol space - spraying or with diesel / kerosene for thermal fogging at recommended application rates of 0 . 5 - 1 g ai / ha for mosquito control and 2 g ai / ha for housefly control .", + "entities": [] + }, + { + "id": "12077", + "type": "gene", + "text": "XXI .", + "entities": [] + }, + { + "id": "12078", + "type": "gene", + "text": "Study on distribution of metal in the teeth treated by iontophoresis with transparent specimens", + "entities": [] + }, + { + "id": "12079", + "type": "gene", + "text": "Parkinsonian patients had a significantly lower prevalence of alcohol use .", + "entities": [] + }, + { + "id": "12080", + "type": "gene", + "text": "Human neuronal Elav - like proteins contain three RNP - type RNA recognition motifs ( RRMs ) .", + "entities": [ + "Human neuronal Elav - like proteins" + ] + }, + { + "id": "12081", + "type": "gene", + "text": "Laboratory studies showed that the direct fluorescent - antibody kits were the least sensitive in this case and did not detect fewer than 10 ( 4 ) elementary bodies per ml , while most ELISA kits detected between 130 and 600 elementary bodies per ml .", + "entities": [] + }, + { + "id": "12082", + "type": "gene", + "text": "Large ones were similar in size to the main lobe and small ones were approximately 1 / 4 of the length of the main lobe .", + "entities": [] + }, + { + "id": "12083", + "type": "gene", + "text": "The interaction of radiation and hyperthermia was systematically studied in the Dunning R3327G prostatic adenocarcinoma , the preeminent animal model for human prostatic cancer .", + "entities": [] + }, + { + "id": "12084", + "type": "gene", + "text": "Although increased expression of the HMG - I / Y proteins is associated with cellular proliferation , neoplastic transformation , and several human cancers , the role of these proteins in the pathogenesis of malignancy remains unclear .", + "entities": [ + "HMG - I / Y proteins" + ] + }, + { + "id": "12085", + "type": "gene", + "text": "This computerized list was linked to the central files of the Massachusetts Cancer Registry and cases diagnosed between 1982 and 1988 were identified .", + "entities": [] + }, + { + "id": "12086", + "type": "gene", + "text": "Adipocyte differentiation of nontransformed cells also markedly represses the ability of SRF to bind to the junB SRE , the c - fos SRE , and other SREs , as determined by mobility shift and gel supershift assays , without affecting the DNA binding characteristics of the nuclear protein SP - 1 .", + "entities": [ + "SRF", + "junB", + "c - fos" + ] + }, + { + "id": "12087", + "type": "gene", + "text": "We also identified Sp1 , Sp3 , and NGFI - A / Egr - 1 as the primary nuclear transcription factors binding to TRE1 which mediate Tax responsiveness .", + "entities": [ + "Sp1", + "Sp3", + "NGFI - A", + "Egr - 1", + "TRE1", + "Tax" + ] + }, + { + "id": "12088", + "type": "gene", + "text": "Echosismography enables to improve the diagnosis when compared with classical sonography in about 20 % of cases .", + "entities": [] + }, + { + "id": "12089", + "type": "gene", + "text": "The enteric route is the principal mode of transmission for hepatitis A , but maximal levels of hepatitis A virus excretion occur before the onset of jaundice .", + "entities": [] + }, + { + "id": "12090", + "type": "gene", + "text": "This paper reviews the middleware - based approach adopted by CEN ENV 12967 - 1 and the specialisation necessary for the healthcare record based on CEN ENV 12265 ' Electronic Healthcare Record Architecture ' .", + "entities": [] + }, + { + "id": "12091", + "type": "gene", + "text": "Plasma renin activity rose and the plasma aldosterone level fell after taking lisinopril .", + "entities": [ + "Plasma renin" + ] + }, + { + "id": "12092", + "type": "gene", + "text": "Expression of neuronal traits in pancreatic beta cells .", + "entities": [] + }, + { + "id": "12093", + "type": "gene", + "text": "Thus , the anti - interferon functions of vIRF - 2 may contribute to the establishment of a chronic or latent infection .", + "entities": [ + "anti - interferon", + "vIRF - 2" + ] + }, + { + "id": "12094", + "type": "gene", + "text": "In lean mice , the fat / water intensity ratio was about 1 : 4 , about half that in normal mice .", + "entities": [] + }, + { + "id": "12095", + "type": "gene", + "text": "ORF1 ( 1029 bp ; EMBL databank , Accession No .", + "entities": [] + }, + { + "id": "12096", + "type": "gene", + "text": "Epididymal growth was retarded in animals maintained solely on chickpea haulm and improved with supplementation .", + "entities": [] + }, + { + "id": "12097", + "type": "gene", + "text": "The intron 8 enhancer region was not activated by GATA - 1 together with Sp1 in transactivation experiments in COS - 1 cells indicating the involvement of a related Sp1 protein or of another unidentified erythroid factor .", + "entities": [ + "GATA - 1", + "Sp1", + "Sp1 protein" + ] + }, + { + "id": "12098", + "type": "gene", + "text": "Heparin ( 100 U . kg ( - 1 ) . day ( - 1 ) ) was injected subcutaneously to the rats in H group while normal saline to those in N group once a day .", + "entities": [] + }, + { + "id": "12099", + "type": "gene", + "text": "Mature and old B6AF1 and B6D2F1 mice were given acidified tap water or promethazine HCl ( a phenothiazine with H1 receptor blocking activity ) , chlorpheniramine ( an H1 blocker ) or trifluoperazine ( a phenothiazine with no H1 blocking activity ) in their drinking water , and the effects of these agents on bone mineral content were assessed by intermittently measuring the 24 - h whole body retention of Tc 99m methylene diphosphonate ( Tc 99m MDP , an indicator of bone metabolism ) and at the end of the studies by determining ash weights of femur , ilium and sacrum .", + "entities": [ + "H1 receptor", + "H1", + "H1" + ] + }, + { + "id": "12100", + "type": "gene", + "text": "PATIENTS AND METHODS : One hundred eighty - four chemotherapy - naive patients receiving high - dose cisplatin ( 81 to 120 mg / m2 ) were randomized to receive one of four granisetron doses ( 5 , 10 , 20 , or 40 micrograms / kg ) administered before chemotherapy .", + "entities": [] + }, + { + "id": "12101", + "type": "gene", + "text": "The dose was 50 Gy / 20 fractions / 5 weeks .", + "entities": [] + }, + { + "id": "12102", + "type": "gene", + "text": "Prevention of maternal Rh sensitization : anti - Rh immune globulin .", + "entities": [ + "anti - Rh immune globulin" + ] + }, + { + "id": "12103", + "type": "gene", + "text": "An unusual feature of these replicative genes is that the smaller mRNA begins within a long open reading frame of the larger mRNA .", + "entities": [] + }, + { + "id": "12104", + "type": "gene", + "text": "The serum levels of IgE , and asIgE and IgG - 4 against 14 common food allergens were determined .", + "entities": [ + "IgE", + "asIgE", + "IgG - 4" + ] + }, + { + "id": "12105", + "type": "gene", + "text": "The results showed that MIP , MMIF , FIC , Wimax , P0 . 1 and minute ventilation ( Vr ) were significantly increased after administration of methylphenidatum and aminophylline .", + "entities": [] + }, + { + "id": "12106", + "type": "gene", + "text": "In some instances , this is partly mediated by the expression of virally encoded proteases which lead to the cleavage of initiation factor eIF4G .", + "entities": [ + "initiation factor eIF4G" + ] + }, + { + "id": "12107", + "type": "gene", + "text": "METHODS AND RESULTS : Studies were undertaken in 9 isolated guinea pig hearts , which demonstrated reverse use - dependent prolongation of cardiac repolarization by 100 nmol / L domperidone .", + "entities": [] + }, + { + "id": "12108", + "type": "gene", + "text": "The large fluxes of 239 + 240Pu might be attributed to episodic lateral transport of particles that flow down the continental slope with the nepheloid layer which was considered to be significant for 239 + 240Pu transport on the continental slope in the East China Sea .", + "entities": [] + }, + { + "id": "12109", + "type": "gene", + "text": "Relationship of mast cells to sarcoidosis granuloma of the skin", + "entities": [] + }, + { + "id": "12110", + "type": "gene", + "text": "Additionally in seven subjects adrenaline ( A ) and noradrenaline ( NA ) concentrations were determined .", + "entities": [] + }, + { + "id": "12111", + "type": "gene", + "text": "Therefore the binding sites for liver - enriched factors , present in the hamster CYP7A1 proximal promoter in close vicinity and conserved between species , constitute a regulatory unit important for basal hepatic expression and tissue restriction of the action of hormones such as insulin .", + "entities": [ + "hamster CYP7A1 proximal promoter", + "insulin" + ] + }, + { + "id": "12112", + "type": "gene", + "text": "Differential expression and regulation by 20 - hydroxyecdysone of mosquito ultraspiracle isoforms .", + "entities": [] + }, + { + "id": "12113", + "type": "gene", + "text": "These changes at the site of injection consist of a focal abnormality characterized by a slight increase in signal intensity on T1 weighted images and markedly increased signal intensity on T2 weighted images .", + "entities": [] + }, + { + "id": "12114", + "type": "gene", + "text": "We now show that the BAT1 translation product is the homolog of the rat p47 nuclear protein , the WM6 Drosophila gene product , and probably also Ce08102 of Caenorhabditis elegans , all members of the DEAD protein family of ATP - dependent RNA helicases .", + "entities": [ + "BAT1 translation product", + "rat p47 nuclear protein", + "WM6 Drosophila gene product", + "Ce08102", + "DEAD protein family", + "ATP - dependent RNA helicases" + ] + }, + { + "id": "12115", + "type": "gene", + "text": "Identification of a promoter - specific transactivation domain in the herpes simplex virus regulatory protein ICP4 .", + "entities": [ + "herpes simplex virus regulatory protein ICP4" + ] + }, + { + "id": "12116", + "type": "gene", + "text": "The effects of c - myc were further dissected by showing that c - myc can inhibit differentiation independently of Id , a negative regulator of muscle differentiation .", + "entities": [ + "c - myc", + "c - myc", + "Id" + ] + }, + { + "id": "12117", + "type": "gene", + "text": "In this method , PLP in plasma can be determined with high sensitivity using derivatization with sodium bisulfite in the mobile phase .", + "entities": [] + }, + { + "id": "12118", + "type": "gene", + "text": "The role of ' scientific psychiatry ' in understanding patients with chronic schizophrenia or severe personality disorder .", + "entities": [] + }, + { + "id": "12119", + "type": "gene", + "text": "The psychologic factors associated wth serious illness , terminal prognoses , and dying complicate the scenario even more as compared with that of nonmalignant pain .", + "entities": [] + }, + { + "id": "12120", + "type": "gene", + "text": "Theory and applications of pulse dosing : a summary of the symposium .", + "entities": [] + }, + { + "id": "12121", + "type": "gene", + "text": "Relationship between gross lesions and Escherichia coli serotypes in chronic respiratory disease ( CRD ) of poultry .", + "entities": [] + }, + { + "id": "12122", + "type": "gene", + "text": "Elimination of gamma - irradiation induced oxidation in aqueous drug preparations", + "entities": [] + }, + { + "id": "12123", + "type": "gene", + "text": "Ste18p was targeted to the plasma membrane even in the absence of prenylation or thioacylation .", + "entities": [ + "Ste18p" + ] + }, + { + "id": "12124", + "type": "gene", + "text": "Transforming growth factor ( TGF ) - beta1 induces extracellular matrix deposition and proliferation of mesenchymal cells .", + "entities": [ + "Transforming growth factor ( TGF ) - beta1" + ] + }, + { + "id": "12125", + "type": "gene", + "text": "However , its participation in gagging induced by oropharyngeal irritation is unclear .", + "entities": [] + }, + { + "id": "12126", + "type": "gene", + "text": "The growth defect of a reg1 reg2 double mutant is alleviated by a loss - of - function mutation in the SNF1 - encoded protein kinase .", + "entities": [ + "reg2 double mutant", + "SNF1 - encoded protein kinase" + ] + }, + { + "id": "12127", + "type": "gene", + "text": "The B . germanica cyclophilin amino acid sequence shares 83 % identity with the cytosolic cyclophilin isoform from Drosophila melanogaster ( Cyp - 1 ) .", + "entities": [ + "B . germanica cyclophilin amino acid sequence", + "cytosolic cyclophilin isoform from Drosophila melanogaster", + "Cyp - 1" + ] + }, + { + "id": "12128", + "type": "gene", + "text": "Ventricular volume stiffness vs . the mean wall stress relationship of LVH shifted upward , whereas the normalized wall muscle stiffness vs . the mean wall stress relationship of LVH showed a smaller slope .", + "entities": [] + }, + { + "id": "12129", + "type": "gene", + "text": "Strontium chloride Sr 89 is costly , but preliminary analysis indicates that it may reduce management expenditures overall . ( ABSTRACT TRUNCATED AT 250 WORDS )", + "entities": [] + }, + { + "id": "12130", + "type": "gene", + "text": "Nor is such adjustment possible unless one posits a model that relates the missing observations to other observed information for each subject - models that are inherently untestable .", + "entities": [] + }, + { + "id": "12131", + "type": "gene", + "text": "Rare neurogenic tumor with metastasis to mouth , jaw and face regions", + "entities": [] + }, + { + "id": "12132", + "type": "gene", + "text": "We suggest that such occlusions occurred at the time of the infarction .", + "entities": [] + }, + { + "id": "12133", + "type": "gene", + "text": "The findings are compatible with the idea that the genes encoding PDGF receptors in glioma cells are regulated in concert with other genes , the expression of which may reflect the developmental program of normal glia cell lineages .", + "entities": [ + "PDGF receptors" + ] + }, + { + "id": "12134", + "type": "gene", + "text": "Identical results were obtained when transfections and mobility shift assays were performed in primary rat hepatocytes in which the endogenous ALS gene is expressed .", + "entities": [ + "ALS gene" + ] + }, + { + "id": "12135", + "type": "gene", + "text": "MBP - Rep68 delta - mediated DNA - RNA helicase activity required ATP hydrolysis and the presence of Mg2 + ions and was inhibited by high ionic strength .", + "entities": [ + "MBP", + "Rep68 delta" + ] + }, + { + "id": "12136", + "type": "gene", + "text": "Evidence for the involvement of the Glc7 - Reg1 phosphatase and the Snf1 - Snf4 kinase in the regulation of INO1 transcription in Saccharomyces cerevisiae .", + "entities": [ + "Glc7", + "Reg1", + "Snf1", + "Snf4", + "INO1" + ] + }, + { + "id": "12137", + "type": "gene", + "text": "However , we identified a gene between the MDV2 UL54 and UL55 genes with homology to the first ORF ( ORF - 1 ) of equine herpesvirus type 1 and corresponding gene identified in pseudorabies virus .", + "entities": [ + "MDV2 UL54", + "UL55 genes", + "first ORF ( ORF - 1 ) of equine herpesvirus type 1" + ] + }, + { + "id": "12138", + "type": "gene", + "text": "Molecular cloning of the polypeptide component of the Rel - related human p75 nucleoprotein complex has revealed its identity with the 65 - kDa ( p65 ) subunit of NF - kappa B .", + "entities": [ + "Rel - related human p75 nucleoprotein complex", + "p65", + "NF - kappa B" + ] + }, + { + "id": "12139", + "type": "gene", + "text": "Thus , while the folds of all Myb domains resemble each other closely , the function of each Myb domain depends on the amino acid residues that are located on the surface of each protein .", + "entities": [ + "Myb domains", + "Myb domain" + ] + }, + { + "id": "12140", + "type": "gene", + "text": "The solitary kidney : a model of chronic hyperfiltration in humans .", + "entities": [] + }, + { + "id": "12141", + "type": "gene", + "text": "Brief report .", + "entities": [] + }, + { + "id": "12142", + "type": "gene", + "text": "Deletion of the NF - IL6 beta leucine zipper domain also greatly diminished the interaction between these two proteins .", + "entities": [ + "NF - IL6 beta leucine zipper domain" + ] + }, + { + "id": "12143", + "type": "gene", + "text": "It is surprising that dnaE173 , a potent mutator mutation specific for sequence substitution as well as single - base frameshift , did not enhance the frequency of the hot - spot frameshift mutation .", + "entities": [] + }, + { + "id": "12144", + "type": "gene", + "text": "Separation of malaria - infected erythrocytes from whole blood : use of a selective high - gradient magnetic separation technique .", + "entities": [] + }, + { + "id": "12145", + "type": "gene", + "text": "Further , the PIP2 content of the 85 - 90 kDa protein appeared to decrease with CSF - 1 treatment .", + "entities": [ + "CSF - 1" + ] + }, + { + "id": "12146", + "type": "gene", + "text": "Prevention of acute paraquat toxicity in rats by superoxide dismutase .", + "entities": [ + "superoxide dismutase" + ] + }, + { + "id": "12147", + "type": "gene", + "text": "Further analysis of AP - 1 DNA binding activities in 7 - to 14 - day culture activated HSCs led to the discovery of high mobility AP - 1 complexes ( HMAP - 1 ) .", + "entities": [ + "AP - 1", + "high mobility AP - 1 complexes", + "HMAP - 1" + ] + }, + { + "id": "12148", + "type": "gene", + "text": "The nmr gene is the major negative regulatory gene in the nitrogen control circuit of Neurospora crassa , which , together with positive regulatory genes , governs the expression of multiple unlinked structural genes of the circuit .", + "entities": [ + "nmr gene" + ] + }, + { + "id": "12149", + "type": "gene", + "text": "An intravenous preparation of doxycycline ( DOTC , Vibramycin ' Pfizer ' ) , a long - lasting tetracycline , was administered mainly by drip infusion for a series of study in the pediatrics field , and the results were as follows : 1 ) DOTC ( 100 mg ) was dissolved in a 100 ml of glucose solution and 2 - - 3 mg / kg was administered intravenously .", + "entities": [] + }, + { + "id": "12150", + "type": "gene", + "text": "The importance of these sites for transcriptional activation was studied by site - directed mutagenesis followed by promoter function analysis of the mutants with a chloramphenicol acetyltransferase reporter system .", + "entities": [ + "chloramphenicol acetyltransferase reporter" + ] + }, + { + "id": "12151", + "type": "gene", + "text": "In the present study we have investigated the regulatory mechanism for CD95L expression .", + "entities": [ + "CD95L" + ] + }, + { + "id": "12152", + "type": "gene", + "text": "This lack of correlation may be due to variations in the metabolic activity of the endometriotic implants present at different stages of the disease .", + "entities": [] + }, + { + "id": "12153", + "type": "gene", + "text": "Serum antibody titre was not significantly associated with the recurrence rate or the duration of infection .", + "entities": [] + }, + { + "id": "12154", + "type": "gene", + "text": "The intercistronic gene junctions of vesicular stomatitis virus ( VSV ) contain conserved sequence elements that are important for polyadenylation and transcription termination of upstream transcript as well as reinitiation of transcription of downstream transcript .", + "entities": [] + }, + { + "id": "12155", + "type": "gene", + "text": "The kappa coefficient of agreement between the Patho Dx Kit and the standard method was 0 . 958 .", + "entities": [] + }, + { + "id": "12156", + "type": "gene", + "text": "The bronchial epithelia of all smoke - exposed animals were hyperplastic , and their ultrastructure showed invaginations , tilt of nuclear axes , an increase in the number and size of lysosomes and multivesiculated bodies , and increased numbers of enlarged intramitochondrial granules .", + "entities": [] + }, + { + "id": "12157", + "type": "gene", + "text": "This study demonstrates that alteration of CDKN2 is one of the most frequent genetic abnormalities in prostate cancer and may contribute to prostate carcinogenesis .", + "entities": [ + "CDKN2" + ] + }, + { + "id": "12158", + "type": "gene", + "text": "The ability of BCL - 6 to function as a transcriptional repressor may contribute to its ability to transform B lymphocytes in diffuse large cell lymphoma .", + "entities": [ + "BCL - 6" + ] + }, + { + "id": "12159", + "type": "gene", + "text": "We were interested in studying the relationship between the circadian rhythm in body temperature and 24 - h variations in plasma concentrations of iron , zinc , circulating leukocyte counts , and plasma interleukin 1 ( IL - 1 ) activity .", + "entities": [ + "interleukin 1", + "IL - 1" + ] + }, + { + "id": "12160", + "type": "gene", + "text": "The mutants were obtained by substitution into a molecular clone of M - MuLV DNA by DNA from two acutely transforming viruses , Ableson MuLV ( Ab - MuLV ) and Moloney murine sarcoma virus ( M - MSV ) .", + "entities": [] + }, + { + "id": "12161", + "type": "gene", + "text": "Recovery of carbimazole - induced agranulocytosis following recombinant granulocyte - macrophage colony stimulating factor ( rhGM - CSF ) administration .", + "entities": [ + "recombinant granulocyte - macrophage colony stimulating factor", + "rhGM - CSF" + ] + }, + { + "id": "12162", + "type": "gene", + "text": "A suspected new storage disease in cattle .", + "entities": [] + }, + { + "id": "12163", + "type": "gene", + "text": "A sterol - regulated protease initiates release of the NH2 - terminal segments of sterol regulatory element - binding proteins ( SREBPs ) from cell membranes , thereby allowing them to enter the nucleus and to stimulate transcription of genes involved in the uptake and synthesis of cholesterol and fatty acids .", + "entities": [ + "sterol regulatory element - binding proteins", + "SREBPs" + ] + }, + { + "id": "12164", + "type": "gene", + "text": "To confirm the binding of protein to these sites in cells , we carried out an in vivo genomic footprinting analysis of this portion of the TGF alpha promoter in normal and transformed rat liver epithelial cell lines that express the endogenous gene at varying levels .", + "entities": [ + "TGF alpha promoter" + ] + }, + { + "id": "12165", + "type": "gene", + "text": "There is no TATA box around the transcriptional start points ( tsp ) , as determined by primer extension analysis .", + "entities": [] + }, + { + "id": "12166", + "type": "gene", + "text": "Control subjects ' evoked potentials ( EPs ) were characterized by an initial positivity in the 90 - 140 ms range ( P1 ) at the temporo - occipital site .", + "entities": [] + }, + { + "id": "12167", + "type": "gene", + "text": "Since proteins containing TPR elements are typically involved in multiple protein - protein interactions , we suggest that the 102kD protein interacts within the tri - snRNP with both the U5 and U4 / U6 snRNPs , thus bridging the two particles .", + "entities": [ + "U5", + "U4", + "U6" + ] + }, + { + "id": "12168", + "type": "gene", + "text": "Although some residues are found reactive toward dimethylsulphate and kethoxal in regions predicted to be unpaired by the phylogenetic secondary structure model of 4 . 5S RNA , generally the reactivity is low , and some residues in internal loops are not reactive at all .", + "entities": [ + "4 . 5S RNA" + ] + }, + { + "id": "12169", + "type": "gene", + "text": "METHODS : This retrospective review comprised 2711 eyes that had LASIK between September 1996 and September 1999 .", + "entities": [] + }, + { + "id": "12170", + "type": "gene", + "text": "Neither ethanol regimen impaired spontaneous alternation , but the 4 g ethanol . kg - 1 x day - 1 regimen increased the percent completed trials .", + "entities": [] + }, + { + "id": "12171", + "type": "gene", + "text": "Northern analysis of the 3 . 1 - kb PWP2H cDNA revealed that a 3 . 3 - kb major transcript is ubiquitously expressed in human adult tissues .", + "entities": [ + "3 . 1 - kb PWP2H cDNA" + ] + }, + { + "id": "12172", + "type": "gene", + "text": "From August 1989 to October 1990 , 83 pregnant Chinese women were the subjects for measuring the levels of plasma functional antithrombin III ( AT III ) activity .", + "entities": [ + "antithrombin III", + "AT III" + ] + }, + { + "id": "12173", + "type": "gene", + "text": "Absence of action potentials in frog slow muscle fibres paralysed by botulinum toxin .", + "entities": [ + "botulinum toxin" + ] + }, + { + "id": "12174", + "type": "gene", + "text": "2 . - - concepts of higher nervous function in the USSR .", + "entities": [] + }, + { + "id": "12175", + "type": "gene", + "text": "The gene was expressed as an approximately 1 . 5 - kb mRNA in most nonlymphoid human cells / tissues including prostate , lung , liver , and colon .", + "entities": [] + }, + { + "id": "12176", + "type": "gene", + "text": "However , we did not observe a correlation between serum and seminal plasma PSA levels .", + "entities": [ + "seminal plasma PSA" + ] + }, + { + "id": "12177", + "type": "gene", + "text": "Ligand binding to the receptor complex leads to tyrosine phosphorylation and activation of Janus kinases ( Jak ) , phosphorylation of the signal transducing subunit gp130 , followed by recruitment and phosphorylation of the signal transducer and activator of transcription factors STAT3 and STAT1 and the src homology domain ( SH2 ) - containing protein tyrosine phosphatase ( SHP2 ) .", + "entities": [ + "Janus kinases", + "Jak", + "signal transducing subunit gp130", + "STAT3", + "STAT1", + "src homology domain", + "SH2", + "protein tyrosine phosphatase", + "SHP2" + ] + }, + { + "id": "12178", + "type": "gene", + "text": "Consistent with this finding , beta - catenin interacted directly with the RA receptor ( RAR ) in a retinoid - dependent manner , but not with the retinoid X receptor ( RXR ) , and RAR competed with TCF for beta - catenin binding .", + "entities": [ + "beta - catenin", + "RA receptor", + "RAR", + "retinoid X receptor", + "RXR", + "RAR", + "TCF", + "beta - catenin" + ] + }, + { + "id": "12179", + "type": "gene", + "text": "In contrast to the situation in mammalian cells , prolonged exposure of the agonist ( 24 h ) does not result in down regulation of the remaining 70 % of the receptors .", + "entities": [] + }, + { + "id": "12180", + "type": "gene", + "text": "The author provides a rationale for an interactional view and presents a case in which post - surgical hiccups were successfully treated , using principles developed by the Mental Research Institute .", + "entities": [] + }, + { + "id": "12181", + "type": "gene", + "text": "Grimelius stain was positive , Masson Fontana stain negative .", + "entities": [] + }, + { + "id": "12182", + "type": "gene", + "text": "Upon analysis of the tissue distribution of AAMP , it was found to be expressed strongly in endothelial cells , cytotrophoblasts , and poorly differentiated colon adenocarcinoma cells found in lymphatics .", + "entities": [ + "AAMP" + ] + }, + { + "id": "12183", + "type": "gene", + "text": "We infer that the dominant negative inhibition results from both direct proteolysis of the beta - galactosidase tetramer by the fusion subunit and detour of the tetramer to the lysosome .", + "entities": [ + "beta - galactosidase tetramer" + ] + }, + { + "id": "12184", + "type": "gene", + "text": "Furthermore , formation of foci of transformed RECs by the c - jun / ras combination was augmented 3 - fold by the tumor promoter phorbol 12 - tetradecanoate 13 - acetate .", + "entities": [ + "c - jun", + "ras" + ] + }, + { + "id": "12185", + "type": "gene", + "text": "Functional recognition of 5 ' splice site by U4 / U6 . U5 tri - snRNP defines a novel ATP - dependent step in early spliceosome assembly .", + "entities": [ + "U4", + "U6", + "U5" + ] + }, + { + "id": "12186", + "type": "gene", + "text": "Recombinant expression of a chimeric EGFR / ErbB - 3 receptor in NIH 3T3 fibroblasts allowed us to investigate cytoplasmic events associated with ErbB - 3 signal transduction upon ligand activation .", + "entities": [ + "EGFR", + "ErbB - 3 receptor", + "ErbB - 3" + ] + }, + { + "id": "12187", + "type": "gene", + "text": "0 % ) and IL - 12 ( 42 . 6 % vs .", + "entities": [ + "IL - 12" + ] + }, + { + "id": "12188", + "type": "gene", + "text": "Unlike class II - and III - specific TBP - TAF complexes , the corresponding murine and human class I - specific transcription initiation factor TIF - IB / SL1 exhibits a pronounced selectivity for its homologous promoter .", + "entities": [ + "TBP", + "TAF", + "TIF - IB", + "SL1" + ] + }, + { + "id": "12189", + "type": "gene", + "text": "The results also showed that although oyster shell supplementation generally increased alkaline phosphatase activity , bone mineralization was relatively uninfluenced as judged by the low coefficients of variation ( CV ) of 3 . 14 - 3 . 51 % and 3 . 39 - 4 . 82 % for calcium and phosphorus content in the femur and tibia respectively .", + "entities": [ + "alkaline phosphatase" + ] + }, + { + "id": "12190", + "type": "gene", + "text": "Mutational analysis of chromosomal segment 64AB , a region containing the glutamic acid decarboxylase gene .", + "entities": [ + "glutamic acid decarboxylase gene" + ] + }, + { + "id": "12191", + "type": "gene", + "text": "Results for men who drank up to two drinks per day suggest that if the dependence criteria were invalid , reductions in the prevalence of specific indicators of alcohol dependence would range from 0 . 3 % to 5 . 2 % .", + "entities": [] + }, + { + "id": "12192", + "type": "gene", + "text": "The two larger peptides , one containing amino acids 1 - 228 and the other containing amino acids 85 - 228 , formed dimers in solution and bound DNA specifically as a dimer .", + "entities": [] + }, + { + "id": "12193", + "type": "gene", + "text": "This report expands on previous work with interferon alfa - 2b ( Intron A ; Schering - Plough ) in the treatment of hairy cell leukemia ( HCL ) .", + "entities": [ + "interferon alfa - 2b ( Intron A ; Schering - Plough )" + ] + }, + { + "id": "12194", + "type": "gene", + "text": "In the diabetics , Ca2 + infusions induced a rise of plasma Ca2 + up to 3 . 2 + / - 0 . 1 mmol / 1 and a fall of circulating glucagon ( - 26 . 4 + / - 5 . 7 % ; p less than 0 . 001 ) and glucose ( - 23 . 3 + / - 3 . 6 % ; p less than 0 . 05 ) .", + "entities": [ + "glucagon" + ] + }, + { + "id": "12195", + "type": "gene", + "text": "A noncatalytic domain conserved among cytoplasmic protein - tyrosine kinases modifies the kinase function and transforming activity of Fujinami sarcoma virus P130gag - fps .", + "entities": [ + "cytoplasmic protein - tyrosine kinases", + "Fujinami sarcoma virus P130gag", + "fps" + ] + }, + { + "id": "12196", + "type": "gene", + "text": "Here the conventional tests clearly pointed to the presence of retrocochlear disease .", + "entities": [] + }, + { + "id": "12197", + "type": "gene", + "text": "Furthermore , we notice two potential consensus motifs which are also found in corresponding positions in the genes for the nerve growth factor receptor and the 68 - kDa neurofilament protein .", + "entities": [ + "nerve growth factor receptor", + "68 - kDa neurofilament protein" + ] + }, + { + "id": "12198", + "type": "gene", + "text": "This slope was further significantly decreased at 5 min ischemia ( - 26 . 5 + / - 8 . 8 microm / mmHg ) but returned toward control values in short - term hibernating myocardium at 90 min ischemia ( - 17 . 2 + / - 6 . 6 microm / mmHg ) .", + "entities": [] + }, + { + "id": "12199", + "type": "gene", + "text": "Transient transfection assays using P19 cells revealed that expression of NDRF / NeuroD2 increased the transactivation of the rat insulin promoter element 3 ( RIPE3 ) enhancer up to approximately 12 - fold and that co - expression of catalytically active form of PKN , but not kinase - deficient derivative , resulted in a further threefold increase of NDRF / NeuroD2 - mediated transcription .", + "entities": [ + "NDRF", + "NeuroD2", + "rat insulin promoter element 3", + "RIPE3", + "PKN", + "NDRF", + "NeuroD2" + ] + }, + { + "id": "12200", + "type": "gene", + "text": "9 , 11 - Seco steroids derived from estradiol 3 - methyl ether .", + "entities": [] + }, + { + "id": "12201", + "type": "gene", + "text": "During flexion whiplash , the torque at the occipital condyle reverses its direction at about 25 ms after impact .", + "entities": [] + }, + { + "id": "12202", + "type": "gene", + "text": "Six patients with the diagnosis of acute mania were treated with high doses of the beta - adrenergic blocking agent propranolol .", + "entities": [] + }, + { + "id": "12203", + "type": "gene", + "text": "Within their polypeptide chain , they all contain those conserved features that define a plant CDPK ; kinase catalytic sequences are linked to a calmodulin - like regulatory domain through a junction region .", + "entities": [ + "CDPK", + "calmodulin - like regulatory domain" + ] + }, + { + "id": "12204", + "type": "gene", + "text": "The minus - end - directed microtubule motors , the dyneins , may also constitute a superfamily of force - generating proteins with distinct attachment domains .", + "entities": [ + "dyneins" + ] + }, + { + "id": "12205", + "type": "gene", + "text": "The constraints of primase recognition sequences , nucleotide substrate requirements , and the effects of additional proteins on oligoribonucleotide synthesis by the 63 - kDa gene 4 protein have been examined using templates of defined sequence .", + "entities": [ + "primase recognition sequences", + "63 - kDa gene 4 protein" + ] + }, + { + "id": "12206", + "type": "gene", + "text": "In the present work , the complete genome sequences of Pyrococcus horikoshii and Pyrococcus abyssi , two species in a genus of hyperthermophilic archaeon ( archaebacterium ) , were compared to detect large genome polymorphisms linked with restriction - modification gene homologs .", + "entities": [] + }, + { + "id": "12207", + "type": "gene", + "text": "Gaucher ' s disease is a rare metabolic disorder characterized by the lack of beta - glucocerebrosidase enzyme .", + "entities": [ + "beta - glucocerebrosidase enzyme" + ] + }, + { + "id": "12208", + "type": "gene", + "text": "The results suggested that , depending upon the cell type , gene cotransfer using aminoglycoside resistance as a selectable marker may seriously perturb important cellular control mechanisms such as the PKC pathway leading to activation of gene expression .", + "entities": [ + "PKC" + ] + }, + { + "id": "12209", + "type": "gene", + "text": "Further analysis of this domain by in vitro mutagenesis pointed to a core of hydrophobic and acidic residues as critical for the activity .", + "entities": [] + }, + { + "id": "12210", + "type": "gene", + "text": "The pharmacological effects of the novel compound WEB 1881 FU ( 4 - amino - methyl - 1 - benzyl - pyrrolidine - 2 - one - fumarate ) were investigated .", + "entities": [] + }, + { + "id": "12211", + "type": "gene", + "text": "Simultaneous right and left adrenal and peripheral blood samples were collected for determination of oestrone ( E1 ) and oestradiol ( E2 ) .", + "entities": [] + }, + { + "id": "12212", + "type": "gene", + "text": "Comparison of the p50 sequence to other cloned proteins revealed 89 % homology with a glycosaminoglycan - binding protein and 54 % homology with Drosophila cell cycle control protein ( cdc ) 37 .", + "entities": [ + "p50 sequence", + "Drosophila cell cycle control protein ( cdc )" + ] + }, + { + "id": "12213", + "type": "gene", + "text": "We sought to determine whether such differences in polyadenylation affect the steady - state levels of DHFR and mRNAs expressed from either allele and , in a more general sense , to ask whether differences in 3 ' end RNA processing in a gene containing multiple poly ( A ) sites affects the final level of gene expression .", + "entities": [ + "DHFR" + ] + }, + { + "id": "12214", + "type": "gene", + "text": "CES4 on a multicopy plasmid was unable to suppress tif1 - A79V .", + "entities": [ + "CES4", + "tif1 - A79V" + ] + }, + { + "id": "12215", + "type": "gene", + "text": "Anatomy of the uterine artery .", + "entities": [] + }, + { + "id": "12216", + "type": "gene", + "text": "Processing of the polycistronic precursor requires nucleases also involved in rRNA processing , i . e . , Rnt1p and Rat1p .", + "entities": [ + "Rnt1p", + "Rat1p" + ] + }, + { + "id": "12217", + "type": "gene", + "text": "Sequence comparison indicates that exons 5 ' / L and L / N in PSG12 and PSG12 psi are 99 % identical , except that the L / N exon in the PSG12 psi gene contains a stop codon .", + "entities": [ + "PSG12", + "PSG12 psi", + "PSG12 psi gene" + ] + }, + { + "id": "12218", + "type": "gene", + "text": "In addition , a comparison of the hCHLR gene sequences with available databases indicates that a large portion of these genes , including exons encoding two functional domains of the carboxyl - terminal region of these proteins , has been duplicated as part of a larger human telomeric repeat sequence found on many human chromosomes .", + "entities": [ + "hCHLR gene sequences" + ] + }, + { + "id": "12219", + "type": "gene", + "text": "Since the ETS domain , which is localized in the carboxy terminal region of the encoded protein , is 95 % and 96 % identical to that of PEA3 and ER81 , respectively , we named this new member ' Ets Related Molecule PEA3 - like ' ( ERM ) .", + "entities": [ + "ETS domain", + "PEA3", + "ER81", + "' Ets Related Molecule PEA3 - like '", + "ERM" + ] + }, + { + "id": "12220", + "type": "gene", + "text": "This approximately 125 - nt RNA proved to arise via RNase E cleavage from the 3 ' - terminal region of the mRNAs bearing the terminator .", + "entities": [ + "RNase E" + ] + }, + { + "id": "12221", + "type": "gene", + "text": "CDNA cloning of chick brain alpha - amino - 3 - hydroxy - 5 - methyl - 4 - isoxazolepropionic acid receptors reveals conservation of structure , function and post - transcriptional processes with mammalian receptors .", + "entities": [ + "chick brain alpha - amino - 3 - hydroxy - 5 - methyl - 4 - isoxazolepropionic acid receptors" + ] + }, + { + "id": "12222", + "type": "gene", + "text": "Deletion analysis revealed that the essential domain of this promoter , termed the ORF5 / deltaX transcript promoter , mapped to nucleotides 1525 - 1625 .", + "entities": [ + "ORF5 / deltaX transcript promoter" + ] + }, + { + "id": "12223", + "type": "gene", + "text": "The results of these analyses indicate that the proteinase cleaves at amino acid residues E960 - A961 , E1071 - S1072 , E1345 - T1346 , and E1419 - G1420 ; however , the cleavage efficiency is varied .", + "entities": [] + }, + { + "id": "12224", + "type": "gene", + "text": "We have demonstrated previously that two binding sites in the - 184 HNF - 3 beta promoter are recognized by widely distributed factors and that there is also a critical autoregulatory site , we identified a binding site for a cell - specific factor , LF - H3 beta , that may function in restricting HNF - 3 beta gene expression to hepatocytes .", + "entities": [ + "- 184 HNF - 3 beta promoter", + "LF - H3 beta", + "HNF - 3 beta gene" + ] + }, + { + "id": "12225", + "type": "gene", + "text": "Interestingly , the activated PDGF beta - receptor was found not to bind Crk proteins .", + "entities": [ + "PDGF beta - receptor", + "Crk proteins" + ] + }, + { + "id": "12226", + "type": "gene", + "text": "However , the element proximal to the transcription start site is dependent on the SRE - 1 .", + "entities": [] + }, + { + "id": "12227", + "type": "gene", + "text": "Measurements included bone mineral density of the lumbar spine and proximal femur ( by dual - energy X - ray absorptiometry ) and biochemical markers of bone remodeling ( serum bone - specific alkaline phosphatase by immunoassay and urine deoxypyridinoline by high - pressure liquid chromatography ) .", + "entities": [ + "alkaline phosphatase" + ] + }, + { + "id": "12228", + "type": "gene", + "text": "Recently , our laboratory developed a screen that identified five multicopy suppressors that can rescue lethal strains of clathrin heavy chain - deficient yeast ( Chc - scd1 - i ) to viability .", + "entities": [ + "clathrin", + "Chc", + "scd1 - i" + ] + }, + { + "id": "12229", + "type": "gene", + "text": "MSSP - 1 produced in E . coli as a fusion protein with GST specifically interacted with single - stranded TCTTAT ( plus myc ( H - P ) 21 ) and ACT - ATT ( in minus myc ( H - P ) 21 ) , the consensus of which can be referred to as A / TCTA / TA / TT .", + "entities": [ + "MSSP - 1", + "GST", + "myc", + "myc" + ] + }, + { + "id": "12230", + "type": "gene", + "text": "Use of subcutaneous deferoxamine in a child with hemochromatosis associated with congenital dyserythropoietic anemia , type I .", + "entities": [] + }, + { + "id": "12231", + "type": "gene", + "text": "However , a strongly increased frequency of CpG dinucleotides was found .", + "entities": [] + }, + { + "id": "12232", + "type": "gene", + "text": "TDEYA at doses of 200 to 500 mg / kg significantly suppressed xanthine oxidase ( XO ) activity in the stomach tissue following its oral administration .", + "entities": [ + "xanthine oxidase", + "XO" + ] + }, + { + "id": "12233", + "type": "gene", + "text": "Anti - hepatitis A virus ( HAV ) titer after vaccination was measured in 83 HIV - positive and 39 HIV - negative men .", + "entities": [ + "Anti - hepatitis A" + ] + }, + { + "id": "12234", + "type": "gene", + "text": "Neuronal mechanisms underlying stimulus - response ( S - R ) associations in S - R compatibility tasks were identified in 2 experiments with monkeys .", + "entities": [] + }, + { + "id": "12235", + "type": "gene", + "text": "Autoimmune neutropenia ( AIN ) is a frequent cause of chronic neutropenia especially in youngest children .", + "entities": [] + }, + { + "id": "12236", + "type": "gene", + "text": "Effects of alterations of primer - binding site sequences on human immunodeficiency virus type 1 replication .", + "entities": [] + }, + { + "id": "12237", + "type": "gene", + "text": "Following baseline clinical examination and initial periodontal therapy , 32 patients received mucogingival surgery with free gingival grafts for treatment of insufficient attached gingiva .", + "entities": [] + }, + { + "id": "12238", + "type": "gene", + "text": "The orientations of the contact surfaces and their locations relative to the object ' s center of mass were varied .", + "entities": [] + }, + { + "id": "12239", + "type": "gene", + "text": "These observations establish that RsmC negatively regulates rsmB transcription but positively affects RsmA production .", + "entities": [ + "RsmC", + "rsmB", + "RsmA" + ] + }, + { + "id": "12240", + "type": "gene", + "text": "Sci .", + "entities": [] + }, + { + "id": "12241", + "type": "gene", + "text": "Involvement of early growth response factor Egr - 1 in apolipoprotein AI gene transcription .", + "entities": [ + "early growth response factor Egr - 1", + "apolipoprotein AI gene" + ] + }, + { + "id": "12242", + "type": "gene", + "text": "A pathway for regulation of B lymphocyte antigen receptor - induced calcium flux .", + "entities": [ + "B lymphocyte antigen receptor" + ] + }, + { + "id": "12243", + "type": "gene", + "text": "Summers , Virology 89 : 517 - 527 , 1978 ) .", + "entities": [] + }, + { + "id": "12244", + "type": "gene", + "text": "CONCLUSION : During chronic treatment , the haemodynamic response to oral cilazapril was attenuated , indicating that continued clinical improvement in patients with CHF on CLZ is independent of to its acute haemodynamic effects .", + "entities": [] + }, + { + "id": "12245", + "type": "gene", + "text": "SETTING : University hospital - based , tertiary care infertility center .", + "entities": [] + }, + { + "id": "12246", + "type": "gene", + "text": "Unlike the introns of other duplicated ribosomal protein genes which are highly diverged , the duplicated S13 genes have two nearly identical DNA sequences of 25 and 31 bp in length within their introns .", + "entities": [ + "ribosomal protein genes", + "S13 genes" + ] + }, + { + "id": "12247", + "type": "gene", + "text": "GN101 , YC819 - 9 , and SB3 .", + "entities": [] + }, + { + "id": "12248", + "type": "gene", + "text": "Unlike the typical enhancer element , this region functions in an orientation - dependent manner .", + "entities": [] + }, + { + "id": "12249", + "type": "gene", + "text": "Psychological disturbance was greater in the high life stress group as indicated by significant elevations on the global severity index of the Symptom Checklist - 90 and elevations on somatization , obsessive compulsive , interpersonal sensitivity , depression , anxiety and psychoticism subscales .", + "entities": [] + }, + { + "id": "12250", + "type": "gene", + "text": "Confirmatory statistics included item 2 of the Clinical Global Impression ( CGI ) , the total score of the Sandoz Clinical Assessment Geriatric ( SCAG ) scale , the subscale ' need for help ' of the nurse ' s rating of geriatric patients ( Beurteilungsskala fur geriatrische Patienten ; BGP ) and the total score of the Short Cognitive Performance Test ( Syndrom - Kurztest ; SKT ) .", + "entities": [] + }, + { + "id": "12251", + "type": "gene", + "text": "This observation cannot be explained by the scanning model for ribosomal initiation and suggests that ribosomes may be binding directly at an internal mRNA site at or near the initiator AUG codon for the C protein .", + "entities": [ + "C protein" + ] + }, + { + "id": "12252", + "type": "gene", + "text": "Rather , complete skipping of exon V and subsequent joining of exon IV to exon VI caused a shift in the open reading frame , which remodeled GPHe ( P2 ) with an elongated new hydrophobic sequence for membrane anchoring .", + "entities": [ + "GPHe ( P2 )" + ] + }, + { + "id": "12253", + "type": "gene", + "text": "The mode of resistance to quinupristin / dalfopristin was not evident ( sat A - negative by PCR ) ; and these cases illustrate the existence of streptogramin - resistant isolates before the introduction of this antimicrobial class into human clinical practice .", + "entities": [] + }, + { + "id": "12254", + "type": "gene", + "text": "METHODS : DSF was instilled in one eye chosen at random and CF in the fellow eye of 13 normal subjects and in 13 patients with KCS .", + "entities": [] + }, + { + "id": "12255", + "type": "gene", + "text": "Pathogens ( Staphylococcus aureus or Gram - negative bacilli ) were isolated from only one member of staff in small numbers and irregularly and rarely in large numbers from patients .", + "entities": [] + }, + { + "id": "12256", + "type": "gene", + "text": "Neutron scattering measurements of critical exponents in CsMnBr3 : A Z2 & gt ; = 1 antiferromagnet .", + "entities": [] + }, + { + "id": "12257", + "type": "gene", + "text": "Nevertheless , in view of the potential transmission rates of HGV and the lack of effective immunization , HGV should be regarded as a potential occupational hazard for medical and dental staff .", + "entities": [] + }, + { + "id": "12258", + "type": "gene", + "text": "Effects of cortisone , starvation , and rickets on oxidative enzyme activities of epiphyseal cartilage from rats .", + "entities": [] + }, + { + "id": "12259", + "type": "gene", + "text": "Removal of all core histone tail domains by limited trypsin proteolysis or acetylation of the core histone tails significantly relieves this inhibition and allows TFIIIA to exhibit high - affinity binding to nucleosomal DNA .", + "entities": [ + "core histone", + "trypsin", + "core histone", + "TFIIIA" + ] + }, + { + "id": "12260", + "type": "gene", + "text": "Abbreviations : CAS , CRK - associated substrate ; CH , calponin - homology domain ; CSK , C - terminal SRC kinase ; E6 , Papillomavirus E6 protein ; FAK , focal adhesion kinase ; GIT , GRK interacter ; GPCR , heterotrimeric - G - protein - coupled receptor ; GRK , G - protein - coupled - receptor kinase ; MAPK , mitogen - activated protein kinase ( ERK , p38 , JNK ) ; PAK , p21 - activated kinase ; PBS , paxillin - binding subdomain ; PIX , PAK - interacting exchange factor ; PKL , paxillin kinase linker ; POR1 , partner of Rac ; PS , phosphoserine ; PT , phosphothreonine ; PY , phosphotyrosine ; RTK , growth factor receptor tyrosine kinase ; SH , SRC - homology domain .", + "entities": [ + "CAS", + "CRK - associated substrate", + "CH", + "calponin - homology domain", + "CSK", + "C - terminal SRC kinase", + "E6", + "Papillomavirus E6 protein", + "FAK", + "focal adhesion kinase", + "GIT", + "GRK interacter", + "GPCR", + "heterotrimeric - G - protein - coupled receptor", + "GRK", + "G - protein - coupled - receptor kinase", + "MAPK", + "mitogen - activated protein kinase", + "ERK", + "p38", + "JNK", + "PAK", + "p21 - activated kinase", + "PBS", + "paxillin - binding subdomain", + "PIX", + "PAK - interacting exchange factor", + "PKL", + "paxillin kinase linker", + "POR1", + "partner of Rac", + "RTK", + "growth factor receptor tyrosine kinase", + "SH", + "SRC - homology domain" + ] + }, + { + "id": "12261", + "type": "gene", + "text": "According to their staining affinity for anti - T antibodies , the glandular tissue cells were classified as T - , T + , T + + , and T and the annual changes in the numbers of these cell populations , as well as in the volume occupied by the glandular tissue , were calculated .", + "entities": [ + "anti - T antibodies", + "T", + "T", + "T", + "T" + ] + }, + { + "id": "12262", + "type": "gene", + "text": "Marrow dysplasia is a major characteristic of patients with myelodysplastic syndrome ( MDS ) , along with marrow blastosis , cytopenia and cytogenetic anomalies .", + "entities": [] + }, + { + "id": "12263", + "type": "gene", + "text": "Each repeat consists of 12 nt , coding for the reiterated sequence , K / NPAG .", + "entities": [] + }, + { + "id": "12264", + "type": "gene", + "text": "Because the number of parameters required by a Volterra series grows rapidly with both the length of its memory and the order of its nonlinearity , methods for identifying these models from measurements of input / output data are limited to low - order systems with relatively short memories .", + "entities": [] + }, + { + "id": "12265", + "type": "gene", + "text": "The results suggest followings - - 1 ) both eosinophils and neutrophils participate in hypersecretion of type Ib in atopic cases , and only eosinophils in non - atopic cases .", + "entities": [] + }, + { + "id": "12266", + "type": "gene", + "text": "To see if a pulse oximeter can monitor the fetus during labour we recruited 100 Caucasian women in normal uncomplicated labour .", + "entities": [] + }, + { + "id": "12267", + "type": "gene", + "text": "P .", + "entities": [] + }, + { + "id": "12268", + "type": "gene", + "text": "Two remotely situated exons within the complement C3 gene locus encode an alternate 5 ' end and proximal ORF under the control of a bidirectional promoter .", + "entities": [ + "complement C3" + ] + }, + { + "id": "12269", + "type": "gene", + "text": "These mutants all failed to interact with the TraR fusion in the two - hybrid system .", + "entities": [ + "TraR fusion" + ] + }, + { + "id": "12270", + "type": "gene", + "text": "In addition , we did not detect significant differences in CDR3 sequences of endogenous Ig lambdaL and kappaL chain gene loci cloned from peripheral blood lymphocytes of an NBS patient and of healthy individuals .", + "entities": [ + "CDR3 sequences", + "endogenous Ig lambdaL", + "kappaL chain gene loci" + ] + }, + { + "id": "12271", + "type": "gene", + "text": "The mutant protein is present at levels slightly greater than wild - type , but exhibits the same tissue distribution as wild - type protein , and has approximately normal affinity for known target sequences ( though no DNA targets identified to date require the first cut repeat for binding ) .", + "entities": [] + }, + { + "id": "12272", + "type": "gene", + "text": "Mean total lung capacity , functional residual capacity , and residual volume increased significantly , and the mean closing volume , the lung volume above residual volume at which phase IV begins , decreased significantly with 11 cm H20 continuous positive airway pressure ; differences at 5 cm H20 were not significant .", + "entities": [] + }, + { + "id": "12273", + "type": "gene", + "text": "A comparison of the nucleotide and deduced amino acid sequences of the core regions of the RNA - dependent RNA polymerase domains found in these three dsRNAs suggested that these dsRNAs probably evolved independently within each host plant from a common ancestor .", + "entities": [ + "RNA - dependent RNA polymerase domains" + ] + }, + { + "id": "12274", + "type": "gene", + "text": "CONCLUSIONS : The largest value of the joint space may be used when evaluating rheumatoid AC joint space .", + "entities": [] + }, + { + "id": "12275", + "type": "gene", + "text": "Growth , 4 - PA and 14C turnover data indicated that WB contributed to B - 6 intake of these rats .", + "entities": [] + }, + { + "id": "12276", + "type": "gene", + "text": "Among 9 group I patients with a positive result on head - up tilt - table testing and no evidence of structural heart disease ( mean follow - up 4 . 3 years ) , 7 are without further episodes of syncope ; 3 have discontinued medication and 5 have resumed at least limited exercise .", + "entities": [] + }, + { + "id": "12277", + "type": "gene", + "text": "A favourable response was achieved with a combination of amphotericin B and cotrimoxazole .", + "entities": [] + }, + { + "id": "12278", + "type": "gene", + "text": "The GRE at nucleotide 7640 is a composite GRE ( cGRE ) containing an overlapping activator protein - 1 ( AP - 1 ) motif for the c - jun homodimer and c - jun / c - fos heterodimer .", + "entities": [ + "activator protein - 1", + "AP - 1", + "c - jun homodimer", + "c - jun", + "c - fos" + ] + }, + { + "id": "12279", + "type": "gene", + "text": "Dopamine SERS spectra from these electrodes are similar to those obtained at uncoated electrodes .", + "entities": [] + }, + { + "id": "12280", + "type": "gene", + "text": "Yeast U1 snRNP therefore contains 16 different proteins , including seven snRNP core proteins , three homologues of the metazoan U1 snRNP - specific proteins , and six yeast - specific U1 snRNP proteins .", + "entities": [ + "Yeast U1 snRNP", + "snRNP core proteins", + "metazoan U1 snRNP - specific proteins", + "yeast - specific U1 snRNP proteins" + ] + }, + { + "id": "12281", + "type": "gene", + "text": "It corresponds to the complete mitochondrial presequence and the lipoyl - bearing domain that are encoded by exons I through IV of the functional E2 gene .", + "entities": [ + "E2 gene" + ] + }, + { + "id": "12282", + "type": "gene", + "text": "The effects of pharmacological treatment and professional care and support may improve when dementia is detected in an early stage .", + "entities": [] + }, + { + "id": "12283", + "type": "gene", + "text": "Here we demonstrate genetically that plus - strand DNA synthesis of the yeast Ty1 element is initiated at two sites located at the 5 ' boundary of the 3 ' long terminal repeat ( PPT1 ) and near the middle of the pol gene in the integrase coding sequence ( PPT2 ) .", + "entities": [ + "yeast Ty1 element", + "PPT1", + "pol gene", + "integrase coding sequence", + "PPT2" + ] + }, + { + "id": "12284", + "type": "gene", + "text": "A 13 - bp cis - regulatory element in the LTR promoter of the tobacco retrotransposon Tto1 is involved in responsiveness to tissue culture , wounding , methyl jasmonate and fungal elicitors .", + "entities": [ + "tobacco retrotransposon Tto1" + ] + }, + { + "id": "12285", + "type": "gene", + "text": "Ischaemia was induced by a low flow rate of 0 . 8 mL min - 1 for 30 min , and was followed by a 40 - minute reperfusion .", + "entities": [] + }, + { + "id": "12286", + "type": "gene", + "text": "It has been shown in an animal experiment that alterations of the renal vasculature and parenchyma after hemostasis performed by Infrared - Contact - Coagulation are best shown by intravital magnification angiography ( magnification factor 2 . 22 ) .", + "entities": [] + }, + { + "id": "12287", + "type": "gene", + "text": "Surprisingly , calf thymus CstF contained an additional , novel form of the 64 - kDa subunit with a molecular mass of 70 kDa .", + "entities": [ + "calf thymus CstF" + ] + }, + { + "id": "12288", + "type": "gene", + "text": "Sequencing of zebrafish ( Danio rerio ) bacterial artificial chromosome and P1 artificial chromosome genomic clone fragments and of cDNA clones has led to the identification of five new loci coding for beta subunits of proteasomes ( PSMB ) .", + "entities": [ + "PSMB" + ] + }, + { + "id": "12289", + "type": "gene", + "text": "A reduction of the aspartate aminotransferase activity was observed from 800 mg / kg b . w . / d onwards .", + "entities": [ + "aspartate aminotransferase" + ] + }, + { + "id": "12290", + "type": "gene", + "text": "During insulin infusion , a 20 % dextrose solution was infused by a Biostator in order to maintain the patient ' s glycemia at 90 mg / dl .", + "entities": [ + "insulin" + ] + }, + { + "id": "12291", + "type": "gene", + "text": "The immune response of past - infection of cytomegalovirus in the patients of RTID is rather remarkable .", + "entities": [] + }, + { + "id": "12292", + "type": "gene", + "text": "STP1 is an unessential yeast gene involved in the removal of intervening sequences from some , but not all , families of intervening sequence - containing pre - tRNAs .", + "entities": [ + "STP1" + ] + }, + { + "id": "12293", + "type": "gene", + "text": "METHODS : Rats received continuous intragastric infusion of elemental diet or with supplementation of oatbase , Lactobacillus reuteri R2LC , and Lactobacillus plantarum DSM 9843 , with and without fermentation , from the beginning of the study .", + "entities": [] + }, + { + "id": "12294", + "type": "gene", + "text": "Comparison of the deduced amino acid sequence of gamma - kafirin with the published sequences of gamma - prolamins of maize , and Coix revealed highly conserved domains .", + "entities": [ + "amino acid sequence of gamma - kafirin", + "sequences of gamma - prolamins of maize , and Coix" + ] + }, + { + "id": "12295", + "type": "gene", + "text": "Creutzfeldt - Jakob disease and lyophilised dura mater grafts : report of two cases .", + "entities": [] + }, + { + "id": "12296", + "type": "gene", + "text": "Further , the PIP2 content of the 85 - 90 kDa protein appeared to decrease with CSF - 1 treatment .", + "entities": [ + "CSF - 1" + ] + }, + { + "id": "12297", + "type": "gene", + "text": "In addition , the R206S HSF substitution exhibits constitutive transcriptional activation from a consensus HSE ( HSE2 ) .", + "entities": [ + "R206S HSF" + ] + }, + { + "id": "12298", + "type": "gene", + "text": "1 The effects in normal subjects of a single oral dose of Motival ( one tablet , containing fluphenazine 0 . 5 mg and nortriptyline 10 mg ) on the contingent negative variation ( CNV ) , reaction time , heart rate , blood pressure and self - rating scales for alertness , anxiety , tension , detachment and depression were compared with those of diazepam ( 5 mg and 7 . 5 mg ) and placebo or propranolol ( 60 mg ) .", + "entities": [] + }, + { + "id": "12299", + "type": "gene", + "text": "No somatic mutations were found in any of the samples , suggesting that ING1 is not a tumor suppressor gene target in head and neck cancer .", + "entities": [ + "ING1" + ] + }, + { + "id": "12300", + "type": "gene", + "text": "The clinical tolerance and pharmacokinetics of FCE 22101 ( sodium ( 5R , 6S ) - 6 - [ ( 1R ) - hydroxyethyl ] - 2 - carbamoyloxymethyl - 2 - penem - 3 - carboxylate ) , a new penem antibiotic , have been studied after giving a single i . v . dose of 4 mg . kg - 1 to ten healthy male volunteers .", + "entities": [] + }, + { + "id": "12301", + "type": "gene", + "text": "Maternal seizures had occurred during pregnancy in 52 per cent .", + "entities": [] + }, + { + "id": "12302", + "type": "gene", + "text": "Sterol - mediated suppression of cleavage of SREBP - 1 was found to be dependent on the extreme COOH - terminal region ( residue 1034 to the COOH terminus ) , which exists in two forms as a result of alternative splicing .", + "entities": [ + "SREBP - 1" + ] + }, + { + "id": "12303", + "type": "gene", + "text": "Studies on the method of size reduction of medicinal compounds .", + "entities": [] + }, + { + "id": "12304", + "type": "gene", + "text": "A second isotype of Raja immunoglobulin heavy chain genes has been detected by screening a spleen cDNA library with homologous Raja VH - and CH1 - specific probes complementing the respective regions of the mu - like isotype .", + "entities": [ + "Raja immunoglobulin heavy chain genes", + "Raja VH", + "CH1", + "mu - like isotype" + ] + }, + { + "id": "12305", + "type": "gene", + "text": "Vam7p , a SNAP - 25 - like molecule , and Vam3p , a syntaxin homolog , function together in yeast vacuolar protein trafficking .", + "entities": [ + "Vam7p", + "SNAP - 25 - like molecule", + "Vam3p", + "syntaxin homolog" + ] + }, + { + "id": "12306", + "type": "gene", + "text": "Deletion from either the N - or C - terminal ends of repA ( 28 and 69 codons , respectively , out of the 286 - codon open reading frame ) affected the initiator but not the inhibitory activity .", + "entities": [ + "repA" + ] + }, + { + "id": "12307", + "type": "gene", + "text": "Pancreatic and biliary secretion and gastric emptying rates of a liquid test meal ( LTM ) were determined in normal persons , in patients with subtotal gastrectomy with gastroduodenostomy ( STG - BI ) or with gastrojejunostomy ( STG - BII ) , and in patients with truncal vagotomy and pyloroplasty ( V & P ) .", + "entities": [] + }, + { + "id": "12308", + "type": "gene", + "text": "The predicted Pay4p sequence contains two putative ATP - binding domains and shows structural relationships to other potential ATP - binding proteins involved in biological processes as diverse as peroxisome biogenesis , vesicle - mediated protein transport , cell cycle control , and transcriptional regulation .", + "entities": [ + "Pay4p sequence", + "ATP - binding proteins" + ] + }, + { + "id": "12309", + "type": "gene", + "text": "Systematic review of diagnostic tests for vaginal trichomoniasis .", + "entities": [] + }, + { + "id": "12310", + "type": "gene", + "text": "KEY WORDS : Melaleuca ; Lake Okeechobee ; Littoral zone ; Water level ; Regulation schedule", + "entities": [] + }, + { + "id": "12311", + "type": "gene", + "text": "Diagnostic importance of determining the complement constituents in children with autoimmune thyroiditis", + "entities": [] + }, + { + "id": "12312", + "type": "gene", + "text": "Heterogeneous nuclear ribonucleoprotein A1 binds to the transcription - regulatory region of mouse hepatitis virus RNA .", + "entities": [ + "Heterogeneous nuclear ribonucleoprotein A1" + ] + }, + { + "id": "12313", + "type": "gene", + "text": "An abnormally high percentage of hypertensive patients ( approximately 30 % ) undergoing cardiac catheterization because of anginal pain and / or exercise - induced ST - segment depressions has angiographically normal coronary arteries .", + "entities": [] + }, + { + "id": "12314", + "type": "gene", + "text": "A new hypothesis on mechanisms for inhibiting catalytic subunits by gamma - subunits and activation of a holoenzyme by transducin", + "entities": [] + }, + { + "id": "12315", + "type": "gene", + "text": "A variety of nuclear ribonucleoproteins are believed to associate directly with nascent RNA polymerase II transcripts and remain associated during subsequent nuclear RNA processing reactions , including pre - mRNA polyadenylation and splicing as well as nucleocytoplasmic mRNA transport .", + "entities": [ + "RNA polymerase II transcripts" + ] + }, + { + "id": "12316", + "type": "gene", + "text": "CONCLUSIONS : In essential hypertension an acute protein load induces a decrease in GFR that may normalize under antihypertensive treatment .", + "entities": [] + }, + { + "id": "12317", + "type": "gene", + "text": "Frequent loss of heterozygosity ( LOH ) of > 30 % of the informative cases was observed on chromosomes 3p ( 41 . 1 % ) , 5q ( 52 . 6 % ) , 6p ( 30 . 4 % ) , 8p ( 33 . 3 % ) , 9p ( 35 . 7 % ) , 9q ( 30 . 8 % ) , 11p ( 32 . 4 % ) , 13q ( 52 . 7 % ) , 17p ( 55 . 2 % ) , 17q ( 33 . 3 % ) , 18q ( 45 . 7 % ) , and 19q ( 30 . 4 % ) .", + "entities": [] + }, + { + "id": "12318", + "type": "gene", + "text": "OBJECTIVE : To evaluate the relationship between blood flow in the tumor assessed by color Doppler ultrasound , microvessel density , and vascular endothelial growth factor levels in endometrial carcinoma .", + "entities": [ + "vascular endothelial growth factor" + ] + }, + { + "id": "12319", + "type": "gene", + "text": "The 30 - day mortality in the CPB group and the non - CPB group were 20 % and 4 . 6 % , respectively which was not statistically significant ( p = 0 . 06 ) .", + "entities": [] + }, + { + "id": "12320", + "type": "gene", + "text": "Family visits and involvement in treatment of patients at a state hospital .", + "entities": [] + }, + { + "id": "12321", + "type": "gene", + "text": "Similarity is most striking in the zinc knuckle region , a region characteristic of gag genes of most replication - competent retroelements .", + "entities": [ + "gag genes" + ] + }, + { + "id": "12322", + "type": "gene", + "text": "Here , we correlate Dox effects on cell cycle with changes of E2F / DP complexes and activity in differentiating C2C12 myocytes .", + "entities": [ + "E2F", + "DP" + ] + }, + { + "id": "12323", + "type": "gene", + "text": "We report herein the case of a 30 - year - old man in whom ectopic mediastinal parathyroid adenoma was detected by 99mTc - methoxyisobutylisonitrile scintigraphy ( 99mTc - MIBI ) .", + "entities": [] + }, + { + "id": "12324", + "type": "gene", + "text": "CONCLUSIONS : Serum prolactin concentrations show age related variations in presumably fertile men .", + "entities": [ + "Serum prolactin" + ] + }, + { + "id": "12325", + "type": "gene", + "text": "Delayed hypersensitivity in man : effects of systemic anticoagulation .", + "entities": [] + }, + { + "id": "12326", + "type": "gene", + "text": "The inflation hub of the probe is recreated by modifying a standard USCI Tuohy - Borst Y adaptor and attaching this to the transected probe hypotube .", + "entities": [] + }, + { + "id": "12327", + "type": "gene", + "text": "A comparative study of the total protein profiles of wild - type S . entomophila UC9 and mutant UC21 revealed that the mutant lacked an approximately 44 - kDa protein and overexpressed an approximately 20 - kDa protein .", + "entities": [] + }, + { + "id": "12328", + "type": "gene", + "text": "Hypertonic glucose administered intrajejunally in Heidenhain pouch dogs resulted in an equal inhibition of pentagastrin - induced acid secretion from the pouch and the main stomach , whereas hypertonic saline had no effect .", + "entities": [] + }, + { + "id": "12329", + "type": "gene", + "text": "We established that the 2 . 6 kb mRNA V - 1 and the 2 . 3 kb GGT mRNA V - 2 derive , by alternate splicing , from a primary transcript initiated on a distal promoter on the rat GGT gene .", + "entities": [ + "GGT", + "rat GGT gene" + ] + }, + { + "id": "12330", + "type": "gene", + "text": "After termination of medication the animals were kindled electrically in the nucleus amygdala .", + "entities": [] + }, + { + "id": "12331", + "type": "gene", + "text": "Therefore , the rbcL - rbcS locus seems to be barely expressed under a standard condition for photoautotrophic growth .", + "entities": [ + "rbcL", + "rbcS" + ] + }, + { + "id": "12332", + "type": "gene", + "text": "Subsequently , HD inhibited healing because it significantly delayed epithelialization and caused protracted inflammation .", + "entities": [] + }, + { + "id": "12333", + "type": "gene", + "text": "Furthermore , overexpression of AML3 / CBFalpha1 could rescue the AML1 - ETO repression .", + "entities": [ + "AML3", + "CBFalpha1", + "AML1", + "ETO" + ] + }, + { + "id": "12334", + "type": "gene", + "text": "Gel mobility shift assays using a synthetic E6 motif detected a B - cell - specific complex in addition to a ubiquitous band found also in T cells and HeLa cells .", + "entities": [ + "E6 motif" + ] + }, + { + "id": "12335", + "type": "gene", + "text": "MATERIAL AND METHODS : The authors analyzed 41 persons formerly submitted to surgery ( after 8 years and 4 months , as a mean ) , 31 to highly selective vagotomy , and 10 to truncal or selective vagotomy plus gastroduodenal drainage .", + "entities": [] + }, + { + "id": "12336", + "type": "gene", + "text": "On the other hand factor IX activity is decreased in coumarin treatment with factor IX antigen remaining normal .", + "entities": [ + "factor IX", + "factor IX" + ] + }, + { + "id": "12337", + "type": "gene", + "text": "While no obvious transmembrane regions were identified , several short hydrophobic amino acid stretches were found to be localized in and around the Pro II region , and these may be responsible for attachment of precursors to membranes .", + "entities": [] + }, + { + "id": "12338", + "type": "gene", + "text": "Instead , the results support the idea that Pc group products provide stable memory or imprinting of boundaries which are initially specified by gap and pair - rule regulators .", + "entities": [ + "Pc group products" + ] + }, + { + "id": "12339", + "type": "gene", + "text": "No differences in total cholesterol levels were observed between mapuches and aymaras .", + "entities": [] + }, + { + "id": "12340", + "type": "gene", + "text": "Based on AUC infinity analyses , the pharmacokinetics of buflomedil were found to be linear within the dose ranges studied ( 50 to 200 mg for i . v . injection and 150 to 450 mg for oral administration ) .", + "entities": [] + }, + { + "id": "12341", + "type": "gene", + "text": "Urinary excretion of oestrone , oestradiol - 17 beta and oestriol in pregnancies complicated by steroid sulphatase deficiency .", + "entities": [ + "steroid sulphatase" + ] + }, + { + "id": "12342", + "type": "gene", + "text": "Validity of NIR spectroscopy for quantitatively measuring muscle oxidative metabolic rate in exercise .", + "entities": [] + }, + { + "id": "12343", + "type": "gene", + "text": "The partial categories of the SIP that were more affected were work , recreation and pastimes , home management , and sleep and rest .", + "entities": [] + }, + { + "id": "12344", + "type": "gene", + "text": "However , regional MVO2 increased to about the same extent in the CFX ( from 6 . 0 + / - 0 . 7 to 12 . 4 + / - 0 . 9 ml O2 . min - 1 times 100 g - 1 ) and the LAD region ( from 7 . 0 + / - 0 . 6 to 14 . 5 + / - 1 . 3 ml O2 . min - 1 times 100 g - 1 ) .", + "entities": [] + }, + { + "id": "12345", + "type": "gene", + "text": "The cleavage of Fak by caspases may thus play an important role in the execution of the suicide program by disabling the anti - apoptotic function of Fak .", + "entities": [ + "Fak", + "caspases", + "Fak" + ] + }, + { + "id": "12346", + "type": "gene", + "text": "High - level expression in Escherichia coli of selenocysteine - containing rat thioredoxin reductase utilizing gene fusions with engineered bacterial - type SECIS elements and co - expression with the selA , selB and selC genes .", + "entities": [ + "rat thioredoxin reductase", + "selA", + "selB", + "selC genes" + ] + }, + { + "id": "12347", + "type": "gene", + "text": "Adverse reaction of the apparently healthy partner in response to improvement in the overtly dysfunctional partner .", + "entities": [] + }, + { + "id": "12348", + "type": "gene", + "text": "Structure and localization of the human gene encoding SR - BI / CLA - 1 .", + "entities": [ + "SR - BI", + "CLA - 1" + ] + }, + { + "id": "12349", + "type": "gene", + "text": "During the conditioning procedure , the C - fiber reflex was facilitated ( wind - up ) in a stimulus - dependent fashion in intact , anesthetized animals during the application of the first seven conditioning stimuli ; thereafter , the magnitude of the responses reached a plateau and then decreased .", + "entities": [] + }, + { + "id": "12350", + "type": "gene", + "text": "Four casein kinase I isoforms are differentially partitioned between nucleus and cytoplasm .", + "entities": [ + "casein kinase I isoforms" + ] + }, + { + "id": "12351", + "type": "gene", + "text": "An apparent ufo mRNA overexpression was not found in any of the positive leukemia cell lines , but was identified in the drug - resistant subclones of the cervix carcinoma cell line HeLa .", + "entities": [ + "ufo mRNA" + ] + }, + { + "id": "12352", + "type": "gene", + "text": "In Xenopus laevis , the gene encoding the elongation factor 1 - alpha variant EF - 1 alpha O , where O stands for oocyte , is expressed in oocytes and early embryos .", + "entities": [ + "EF - 1 alpha O" + ] + }, + { + "id": "12353", + "type": "gene", + "text": "As the high - affinity Mg2 + binding sites are filled , the primer terminus migrates from the exonuclease site to a highly based stacked polymerase active site .", + "entities": [] + }, + { + "id": "12354", + "type": "gene", + "text": "Specifically , by oligonucleotide - directed site - specific mutagenesis , we demonstrate that of 10 cysteine residues in the ORF4 polypeptide , only C - 421 and C - 426 are essential for transactivator function and suggest that these cysteine residues may participate in critical protein - protein interactions rather than protein - nucleic acid interactions to mediate ORF4 inducibility .", + "entities": [] + }, + { + "id": "12355", + "type": "gene", + "text": "Pro - inflammatory cytokine , tumor necrosis factor - alpha ( TNF - alpha ) , produced from adipose tissues in obese subjects , is known to play a predominant role in inducing insulin resistance .", + "entities": [ + "tumor necrosis factor - alpha", + "TNF - alpha", + "insulin" + ] + }, + { + "id": "12356", + "type": "gene", + "text": "Total VO2 was decreased in both groups during severe hypoxia but limb VO2 was maintained in the beta - block group .", + "entities": [] + }, + { + "id": "12357", + "type": "gene", + "text": "beta - Block prevented the fall in total and limb peripheral resistance seen in severe hypoxia but did not alter the consistently more efficient utilization of total O2 delivery shown by the limb in comparison to the whole body by higher O2 extraction ratios and lower venous O2 pressure .", + "entities": [] + }, + { + "id": "12358", + "type": "gene", + "text": "beta - Vasodilator receptors evidently played an active part in the vasodilatation seen during severe hypoxia .", + "entities": [ + "beta - Vasodilator receptors" + ] + }, + { + "id": "12359", + "type": "gene", + "text": "The results show that both the amino and carboxy termini of the NS1 protein molecule and the cysteines at residues 337 and 340 are essential for tubule formation .", + "entities": [ + "NS1 protein molecule" + ] + }, + { + "id": "12360", + "type": "gene", + "text": "To determine whether the NTP - binding motif is important for Rad24 function , we mutated the conserved lysine ( 115 ) residue in this motif .", + "entities": [ + "Rad24" + ] + }, + { + "id": "12361", + "type": "gene", + "text": "Aneurysmal bone cyst of the jaws : analysis of 11 cases .", + "entities": [] + }, + { + "id": "12362", + "type": "gene", + "text": "( iv ) The accumulation of cyclin D3 protein in Vero cells infected with an alpha0 deletion mutant was reduced relative to that of cells infected with wild - type virus or a recombinant virus in which the deleted alpha0 sequences were restored .", + "entities": [ + "cyclin D3 protein", + "alpha0 deletion mutant", + "alpha0 sequences" + ] + }, + { + "id": "12363", + "type": "gene", + "text": "Neutrophil : lymphocyte ratio , plasma haptoglobin , and CBG levels were greater ( P < 0 . 01 ) during the INITIAL period than during the PRE or POST periods but did not differ between treatments .", + "entities": [ + "haptoglobin", + "CBG" + ] + }, + { + "id": "12364", + "type": "gene", + "text": "Homology with the human protein is only 34 % in the tandem repeat domain , mainly showing conservation of serines and threonines , presumed sites of O - linked carbohydrate attachment .", + "entities": [] + }, + { + "id": "12365", + "type": "gene", + "text": "Regulatory regions in the promoter and third intron of the growth hormone gene in rainbow trout , Oncorhynchus mykiss walbaum .", + "entities": [ + "growth hormone gene in rainbow trout" + ] + }, + { + "id": "12366", + "type": "gene", + "text": "A larger region upstream of human CMV dbp also mediated replication in transient assays .", + "entities": [ + "human CMV dbp" + ] + }, + { + "id": "12367", + "type": "gene", + "text": "Enzyme histochemical findings in the ultimobranchial body of the horse", + "entities": [] + }, + { + "id": "12368", + "type": "gene", + "text": "Our results favor the possibility that the Drosophila EGF receptor DER / Egfr expressed by the EMA cells functions as a receptor for Vein .", + "entities": [ + "DER", + "Egfr", + "Vein" + ] + }, + { + "id": "12369", + "type": "gene", + "text": "A promising new cement , 4 - META / MMA - TBB opaque resin , has shown remarkable adhesive properties as a bone cement in vivo .", + "entities": [] + }, + { + "id": "12370", + "type": "gene", + "text": "OsBBPI was found to be rapidly induced in rice seedling leaf in response to cut , exogenous jasmonic acid ( JA ) , and two potent protein phosphatase 2A ( PP2A ) inhibitors , cantharidin ( CN ) and endothall ( EN ) , in a light / dark - , time - and dose - dependent manner ; this induction was completely inhibited by cycloheximide ( CHX ) , indicating a requirement for de novo protein synthesis in its induction .", + "entities": [ + "OsBBPI", + "cut", + "protein phosphatase 2A", + "PP2A" + ] + }, + { + "id": "12371", + "type": "gene", + "text": "Surprisingly , the results of several experiments suggest that the TSF genes encode global regulatory factors .", + "entities": [ + "TSF genes" + ] + }, + { + "id": "12372", + "type": "gene", + "text": "tsf1 to tsf6 mutations derepressed expression from yeast CYC - GAL hybrid promoters ( fused to lacZ ) that harbor a variety of operator sequences , and caused pleiotropic defects in cell growth , mating , and sporulation .", + "entities": [ + "tsf1", + "tsf6", + "CYC", + "GAL", + "lacZ" + ] + }, + { + "id": "12373", + "type": "gene", + "text": "Variation in the temporal - spatial distribution of 228Ra and 224Ra in the RES and marrow - free skeleton after incorporation of colloidal ThO2", + "entities": [] + }, + { + "id": "12374", + "type": "gene", + "text": "Androgens and growth .", + "entities": [] + }, + { + "id": "12375", + "type": "gene", + "text": "The hTERT gene encompasses more than 37kb and consists of 16 exons .", + "entities": [ + "hTERT gene" + ] + }, + { + "id": "12376", + "type": "gene", + "text": "Immuno - cytochemistry , using antisera against Campylobacter jejuni , showed that the positive staining in altered epithelial cells were restricted to intracellular organisms having a structure resembling Campylobacter spp .", + "entities": [] + }, + { + "id": "12377", + "type": "gene", + "text": "A conserved role for L1 as a transmembrane link between neuronal adhesion and membrane cytoskeleton assembly .", + "entities": [ + "L1" + ] + }, + { + "id": "12378", + "type": "gene", + "text": "The results showed that IFN - gamma stimulated the rapid accumulation of interferon regulated factor ( IRF ) - 1 mRNA , followed by a delayed and dose - dependent inhibition of alpha1 ( I ) procollagen mRNA expression in skin fibroblasts from several different donors .", + "entities": [ + "IFN - gamma", + "interferon regulated factor ( IRF ) - 1 mRNA", + "alpha1 ( I ) procollagen mRNA" + ] + }, + { + "id": "12379", + "type": "gene", + "text": "Cytological data suggest that the transgenes associate with a nucleolus .", + "entities": [] + }, + { + "id": "12380", + "type": "gene", + "text": "447 microns for A . microcephalum and 350 microns for A . wedli ) , and fewer testes per proglottis ( 44 - 73 vs .", + "entities": [] + }, + { + "id": "12381", + "type": "gene", + "text": "An evolutionary conserved element is essential for somite and adjacent mesenchymal expression of the Hoxa1 gene .", + "entities": [ + "Hoxa1 gene" + ] + }, + { + "id": "12382", + "type": "gene", + "text": "The presence of regulatory sequences for the binding of transcription factors such as NF - kappa B and AP - 2 , whose activation is associated with the immediate response of the cell to an injury , may be an indication of the important role which HO - 1 may play in defense mechanisms against tissue injury .", + "entities": [ + "NF - kappa B", + "AP - 2", + "HO - 1" + ] + }, + { + "id": "12383", + "type": "gene", + "text": "Further studies of mandibular movement at initial tooth contact .", + "entities": [] + }, + { + "id": "12384", + "type": "gene", + "text": "In an effort to isolate genes with down - regulated expression at the mRNA level during oncogenic transformation of human mammary epithelial cells ( MECs ) , we performed subtractive hybridization between normal MEC strain 76N and its radiation - transformed tumorigenic derivative 76R - 30 .", + "entities": [] + }, + { + "id": "12385", + "type": "gene", + "text": "We randomly assigned 1 , 219 subjects to receive either the standard three - times - weekly ( TIW ) interferon alfa - 2b dose ( 3 MIU ) or the once - weekly ( QW ) peginterferon alfa - 2b ( 0 . 5 , 1 . 0 , or 1 . 5 microg / kg ) .", + "entities": [ + "interferon alfa - 2b", + "peginterferon alfa - 2b" + ] + }, + { + "id": "12386", + "type": "gene", + "text": "Then we correlated HRCT findings with the clinical features , pulmonary functions and methacholine PC20 ( PC20M ) and studied their clinical significance .", + "entities": [] + }, + { + "id": "12387", + "type": "gene", + "text": "The sites targeted for mutagenesis , residues 60 , 61 , and 66 , are located within a putative helical loop structure which may be involved in substrate recognition by the enzyme .", + "entities": [] + }, + { + "id": "12388", + "type": "gene", + "text": "The sequencing of the conditional lethal mutation ts - A13 , localized in the nrdE cistron , and the lethality of insertional mutations targeted in the internal region of nrdE and nrdF , demonstrated the essential role of this locus .", + "entities": [ + "nrdE cistron", + "nrdE", + "nrdF" + ] + }, + { + "id": "12389", + "type": "gene", + "text": "In the first part of our study , the highest mutagenicity was revealed by TA98 strain without enzymatic activation , suggesting a direct - acting mutagenicity prevalence in diesel particulate .", + "entities": [] + }, + { + "id": "12390", + "type": "gene", + "text": "Coenzyme Q10 : blood levels and metabolic demand .", + "entities": [] + }, + { + "id": "12391", + "type": "gene", + "text": "Distant spread was found in 46 patients ( 34 % ) , 42 of whom had serum Tg greater than 10 micrograms / l .", + "entities": [ + "Tg" + ] + }, + { + "id": "12392", + "type": "gene", + "text": "These results suggest that , in this experimental model , ACE inhibitors limit the arrhythmias following ischemia - reperfusion and free radical scavenging action of these drugs does not have a major contributory role in their protective effect .", + "entities": [ + "ACE" + ] + }, + { + "id": "12393", + "type": "gene", + "text": "Nevertheless , protein kinase A stimulation induces CREMalpha to activate the complex native promoter in the phosphoenolpyruvate carboxykinase ( PEPCK ) gene .", + "entities": [ + "protein kinase A", + "CREMalpha", + "phosphoenolpyruvate carboxykinase", + "PEPCK" + ] + }, + { + "id": "12394", + "type": "gene", + "text": "OBJECTIVE : To investigate the incidence and presentation of acute pernicious or fulminating beriberi in a general district hospital .", + "entities": [] + }, + { + "id": "12395", + "type": "gene", + "text": "METHODS : Thyroid status was measured at baseline ( 1990 - 93 ) , through assessment of serum antibodies to thyroid peroxidase ( TPO - Abs , positive : > 10 IU / ml ) , serum TSH levels , and when TSH was abnormal ( < 0 . 4 or > 4 . 0 mU / l ) , serum thyroxin levels ( T4 ) .", + "entities": [ + "thyroid peroxidase", + "TPO - Abs", + "serum TSH", + "TSH", + "serum thyroxin" + ] + }, + { + "id": "12396", + "type": "gene", + "text": "GHB , 2 CB , HMB , are some of these recent substances .", + "entities": [] + }, + { + "id": "12397", + "type": "gene", + "text": "The construction of a small library of mouse repetitive DNA has been previously reported ( Pietras et al . , Nucleic Acids Res .", + "entities": [] + }, + { + "id": "12398", + "type": "gene", + "text": "In H4IIE rat hepatoma cells , glucocorticoids , retinoic acid and cyclic AMP ( cAMP ) increase PEPCK gene transcription whereas insulin and phorbol esters have the opposite effect .", + "entities": [ + "PEPCK gene", + "insulin" + ] + }, + { + "id": "12399", + "type": "gene", + "text": "As with VP16 , the transactivation function of Luman is also regulated by HCF .", + "entities": [ + "VP16", + "Luman", + "HCF" + ] + }, + { + "id": "12400", + "type": "gene", + "text": "Thus , the CCAAT box also has tissue - specific characteristics that assist in targeting expression of the alpha - subunit gene to trophoblasts .", + "entities": [ + "alpha - subunit gene" + ] + }, + { + "id": "12401", + "type": "gene", + "text": "Multivariate logistic regression analysis indicated that seropositivity was strongly associated with the prevalence of hepatitis B in an employee ' s country of birth and with age .", + "entities": [] + }, + { + "id": "12402", + "type": "gene", + "text": "Analysis of chromosomal DNA sequence immediately downstream of the transposon insertion identified two open reading frames , designated csrR and csrS , which exhibited sequence similarity to bacterial two - component regulatory systems .", + "entities": [ + "csrR", + "csrS" + ] + }, + { + "id": "12403", + "type": "gene", + "text": "Expression of PTPRO was also observed in human CD34 + bone marrow cells and 5 - FU - treated murine primitive stem cells .", + "entities": [ + "PTPRO", + "human CD34 +" + ] + }, + { + "id": "12404", + "type": "gene", + "text": "The extents of phosphorylation of Ser44 and Ser64 were 1 : 1 , whereas those of the four minor sites all together were < 30 % of the major one .", + "entities": [] + }, + { + "id": "12405", + "type": "gene", + "text": "Deletion analysis indicates that TBP and hTAFII18 bind to distinct domains of hTAFII28 .", + "entities": [ + "TBP", + "hTAFII18", + "hTAFII28" + ] + }, + { + "id": "12406", + "type": "gene", + "text": "hTAFII18 also interacts with TBP , but it interacts more strongly with hTAFII28 and hTAFII30 .", + "entities": [ + "hTAFII18", + "TBP", + "hTAFII28", + "hTAFII30" + ] + }, + { + "id": "12407", + "type": "gene", + "text": "We developed a system for domain shuffling to establish the function of C1 domains from human Raf kinase and rat PKC eta in yeast .", + "entities": [ + "C1", + "human Raf kinase", + "rat PKC eta" + ] + }, + { + "id": "12408", + "type": "gene", + "text": "A - - A natural hydrostatic phenomenon , at the level of the ends of the plantar arcs , diffuses body weight , as PAIN plays the role of outsentry ( fig . - - 1 ) ( 5 ) ; B - - Plantar perforating ulceration ( PPU ) is caused by a combination of INSENSITIVITY and TRAUMATIS ( 1 ) ; C - - The patient reposing , as body weight ( traumatism ) effects disappear , cicatrization process can be easily observed ; D - - PNEUMATIC INSOLE , being elastic , diffuses localized compression at the ends of the plantar arcs , reduces attrition , makes easier blood circulation , as well as cure and prophylaxis of PPU ( fig . - - 6 ) ( 3 ) .", + "entities": [] + }, + { + "id": "12409", + "type": "gene", + "text": "Grossly , the incidence of a type IIc carcinoma was 46 . 5 % and that of a IIc + III type was 20 . 5 % , respectively .", + "entities": [] + }, + { + "id": "12410", + "type": "gene", + "text": "We interpret these data as further evidence that interaction with a small GTPase is the main regulatory function of the C1 domain in yeast .", + "entities": [ + "small GTPase", + "C1" + ] + }, + { + "id": "12411", + "type": "gene", + "text": "A safe and simple system for the detection of sudden infant death syndrome ( SIDS ) is proposed .", + "entities": [] + }, + { + "id": "12412", + "type": "gene", + "text": "During latency , more than 1 % of neurons in ganglia that innervate the footpad expressed beta - galactosidase , with the number of positive cells remaining constant for at least 5 months .", + "entities": [ + "beta - galactosidase" + ] + }, + { + "id": "12413", + "type": "gene", + "text": "Human granulocyte - macrophage colony - stimulating factor ( hGM - CSF ) activates a set of genes such as c - fos , jun , myc , and early growth response gene 1 ( egr - 1 ) .", + "entities": [ + "Human granulocyte - macrophage colony - stimulating factor", + "hGM - CSF", + "c - fos", + "jun", + "myc", + "early growth response gene 1", + "egr - 1" + ] + }, + { + "id": "12414", + "type": "gene", + "text": "The biochemical and molecular spectrum of ornithine transcarbamylase deficiency .", + "entities": [ + "ornithine transcarbamylase" + ] + }, + { + "id": "12415", + "type": "gene", + "text": "The present investigation sought to identify the principal dimensions of the Framingham Type A scale ( FTAS ) and then to examine their physiological and psychological correlates .", + "entities": [] + }, + { + "id": "12416", + "type": "gene", + "text": "Tolerance to fenfluramine anorexia : fact or fiction ?", + "entities": [] + }, + { + "id": "12417", + "type": "gene", + "text": "Recent findings in this laboratory with regard to tolerance to fenfluramine anorexia are reviewed with respect to generality of the behavioural phenomenon .", + "entities": [] + }, + { + "id": "12418", + "type": "gene", + "text": "Fetal growth retardation as a cause of impaired ovarian development .", + "entities": [] + }, + { + "id": "12419", + "type": "gene", + "text": "The effects of dominant interfering forms of the JNK / p38 signaling pathway demonstrate that activation of these kinases is critical for cytokine - induced E - selectin gene expression .", + "entities": [ + "JNK", + "p38", + "E - selectin gene" + ] + }, + { + "id": "12420", + "type": "gene", + "text": "Ras - GRF1 transiently expressed with v - Src was tyrosine - phosphorylated and showed significant GEF activity toward Rac , but not Rho and Cdc42 , which was comparable with that induced by Gbetagamma .", + "entities": [ + "Ras", + "GRF1", + "v - Src", + "GEF", + "Rac", + "Rho", + "Cdc42", + "Gbetagamma" + ] + }, + { + "id": "12421", + "type": "gene", + "text": "The use of CRF - 41 in the differential diagnosis of Cushing ' s syndrome and obesity .", + "entities": [ + "CRF - 41" + ] + }, + { + "id": "12422", + "type": "gene", + "text": "Vitrectomy and removal of retained lens fragments restores good visual acuity and reduces secondary glaucoma in the majority of patients .", + "entities": [] + }, + { + "id": "12423", + "type": "gene", + "text": "Nucleotide sequence analysis of the HA gene in these two mutants confirmed the HA - phenotype .", + "entities": [ + "HA gene", + "HA -" + ] + }, + { + "id": "12424", + "type": "gene", + "text": "The character of specific immune response in 101 immunized children and in 12 adults belonging to a high risk group with respect to VHB .", + "entities": [] + }, + { + "id": "12425", + "type": "gene", + "text": "Analysis of mig / CAT chimeric constructs transiently transfected into the RAW 264 . 7 mouse monocytic cell line revealed a unique IFN - gamma - responsive element ( gamma RE - 1 ) .", + "entities": [ + "mig", + "CAT", + "IFN - gamma - responsive element", + "gamma RE - 1" + ] + }, + { + "id": "12426", + "type": "gene", + "text": "The MSY2 associated kinase is not casein kinase 2 , the kinase believed to phosphorylate mRNP3 + 4 in oocytes , but a yet unidentified kinase .", + "entities": [ + "MSY2", + "casein kinase 2", + "mRNP3 + 4" + ] + }, + { + "id": "12427", + "type": "gene", + "text": "A key event in this process is the selective recognition of the target membrane by the vesicle and the current view is that SNARE protein interactions likely play a central role in vesicle - target recognition and or membrane fusion .", + "entities": [ + "SNARE protein" + ] + }, + { + "id": "12428", + "type": "gene", + "text": "The average values were 199 and 424 revertants / g for the hamburgers and hot dogs , respectively .", + "entities": [] + }, + { + "id": "12429", + "type": "gene", + "text": "Ca2 + / calmodulin - dependent protein kinase II ( CaMK II ) is a multifunctional serine / threonine protein kinase that regulates ion channels , metabolic enzymes , cytoskeletal proteins , and possibly transcription factors .", + "entities": [ + "Ca2 + / calmodulin - dependent protein kinase II", + "CaMK II", + "serine / threonine protein kinase" + ] + }, + { + "id": "12430", + "type": "gene", + "text": "Insulin - regulated events , however , occur in all cells .", + "entities": [ + "Insulin" + ] + }, + { + "id": "12431", + "type": "gene", + "text": "In vitro binding studies using GST fusion proteins and yeast extracts defined distinct binding sites on yAP180A for Pan1p and clathrin .", + "entities": [ + "GST", + "yAP180A", + "Pan1p", + "clathrin" + ] + }, + { + "id": "12432", + "type": "gene", + "text": "yAP180 proteins and Pan1p , like actin , localize to peripheral patches along the plasma membrane .", + "entities": [ + "yAP180 proteins", + "Pan1p", + "actin" + ] + }, + { + "id": "12433", + "type": "gene", + "text": "In summary , the efficacies of adjuvant carboplatin and of abdominal radiotherapy seem to be identical .", + "entities": [] + }, + { + "id": "12434", + "type": "gene", + "text": "Host lipids in tuberculous infection .", + "entities": [] + }, + { + "id": "12435", + "type": "gene", + "text": "Trichloroethylene , in turn , increased the AUC 5 . 0 ( 1 . 9 - 13 . 4 ) , 25 . 8 ( 8 . 2 - 80 . 8 ) and 2 . 9 ( 1 . 6 - 5 . 4 ) , respectively , whereas the corresponding values for n - hexane were 1 . 9 ( 0 . 7 - 5 . 1 ) , 1 . 5 ( 0 . 5 - 4 . 6 ) , and 3 . 2 ( 1 . 8 - 5 . 9 ) .", + "entities": [] + }, + { + "id": "12436", + "type": "gene", + "text": "Transient expression of VSF - 1 in protoplasts stimulated vs - 1 dependent activation of the - 76 / grp1 . 8 minimal promoter .", + "entities": [ + "VSF - 1", + "vs - 1", + "- 76 / grp1 . 8 minimal promoter" + ] + }, + { + "id": "12437", + "type": "gene", + "text": "Experiences with the clinical and experimental use of Urat - I lithotriptor .", + "entities": [] + }, + { + "id": "12438", + "type": "gene", + "text": "Isolated calcaneal tuberculous osteomyelitis .", + "entities": [] + }, + { + "id": "12439", + "type": "gene", + "text": "These results demonstrate that although PI2 and PI3 viruses belong to the same parainfluenza virus genus , these viruses show marked differences with respect to functional requirements for the cytoplasmic tail of the F glycoprotein .", + "entities": [ + "F glycoprotein" + ] + }, + { + "id": "12440", + "type": "gene", + "text": "Health : an integrative reticulum .", + "entities": [] + }, + { + "id": "12441", + "type": "gene", + "text": "Except for nonperfusion of neurosensory retinal vessels at a light dose of 150 J / cm2 , no other adverse events were of concern .", + "entities": [] + }, + { + "id": "12442", + "type": "gene", + "text": "GR63178A is a water - soluble analogue of mitoquidone , a pentacyclic pyrroloquinone .", + "entities": [] + }, + { + "id": "12443", + "type": "gene", + "text": "Pseudomonas aeruginosa exotoxin A : its role in retardation of wound healing : the 1992 Lindberg Award .", + "entities": [ + "Pseudomonas aeruginosa exotoxin A" + ] + }, + { + "id": "12444", + "type": "gene", + "text": "Regression analyses identified 7 risk and 7 protective factors with minimal overlap .", + "entities": [] + }, + { + "id": "12445", + "type": "gene", + "text": "Gastrointestinal manifestations of systemic sclerosis", + "entities": [] + }, + { + "id": "12446", + "type": "gene", + "text": "The Scales of Cognitive Impairment Rated From Institutional Records ( SCIRFIR ) , a battery based on commonly used dementia rating instruments , was tested on the records of 26 chronically institutionalized , elderly schizophrenia patients , for the purpose of retrospectively evaluating the long - term course of cognitive change in schizophrenia and relating it to available autopsy materials .", + "entities": [] + }, + { + "id": "12447", + "type": "gene", + "text": "Analysis for DNA - protein interactions by in vitro DNase - I footprinting identified a broad region of protection extending from nt - 12 to + 38 .", + "entities": [ + "DNase - I" + ] + }, + { + "id": "12448", + "type": "gene", + "text": "Except for nonperfusion of neurosensory retinal vessels at a light dose of 150 J / cm2 , no other adverse events were of concern .", + "entities": [] + }, + { + "id": "12449", + "type": "gene", + "text": "The ability of rats with control or hippocampal lesions to learn an object - place , odor - place , or object - odor paired - associate task was assessed in a cheeseboard maze apparatus .", + "entities": [] + }, + { + "id": "12450", + "type": "gene", + "text": "Emergency treatment of facial and maxillary / mandibular injuries", + "entities": [] + }, + { + "id": "12451", + "type": "gene", + "text": "The men self - selected a prescribed diet at home emphasizing saturated fat as the visible fat for 1 week .", + "entities": [] + }, + { + "id": "12452", + "type": "gene", + "text": "We propose that TFOs represent a therapeutic potential to specifically diminish the expression of c - sis / PDGF - B proto - oncogene in various pathologic settings where constitutive expression of this gene has been observed .", + "entities": [ + "c - sis", + "PDGF - B" + ] + }, + { + "id": "12453", + "type": "gene", + "text": "( 1997 ) Nature 387 , 370 - 376 ) ] , we suggest that the metal fluoride ions replaced phosphate at the two ATP - binding sites of the iron protein , Kp2 .", + "entities": [ + "Kp2" + ] + }, + { + "id": "12454", + "type": "gene", + "text": "These features were considered consistent with a diagnosis of Rothmund - Thomson syndrome .", + "entities": [] + }, + { + "id": "12455", + "type": "gene", + "text": "Visidex I is unsuitable for storage and re - reading .", + "entities": [] + }, + { + "id": "12456", + "type": "gene", + "text": "CONCLUSIONS : Significant elevations of IL - 1alpha and IL - 1beta occur in patients with bacterial cystitis and microscopic hematuria .", + "entities": [ + "IL - 1alpha", + "IL - 1beta" + ] + }, + { + "id": "12457", + "type": "gene", + "text": "Two promoters were identified by S1 nuclease mapping : P1 , which lies about 72 bp upstream from the structural gene ; and P2 , which lies about 35 bp upstream .", + "entities": [ + "S1 nuclease" + ] + }, + { + "id": "12458", + "type": "gene", + "text": "The size of the group allocated to the good compliance category by the use of the digoxin marker was equivalent in size to a group of patients who had returned less than 15 % of their prescribed dose or reported a deviation of less than 6 % from their prescription .", + "entities": [] + }, + { + "id": "12459", + "type": "gene", + "text": "Plasma NE was also low in the anephric group ( 289 mg / liter + / - 126 ( 1 SD ) vs 612 + / - 189 , P = 0 . 033 , resting ) . ( ABSTRACT TRUNCATED AT 250 WORDS )", + "entities": [] + }, + { + "id": "12460", + "type": "gene", + "text": "In the latter category particular emphasis is being placed on new anthracycline analogues of doxorubicin and analogues of cisplatinum diammine dichloride .", + "entities": [] + }, + { + "id": "12461", + "type": "gene", + "text": "An experimental long - term study .", + "entities": [] + }, + { + "id": "12462", + "type": "gene", + "text": "Fermentation process after supplementation of nitrate , nitrite , lactic acid bacteria and formic acid", + "entities": [] + }, + { + "id": "12463", + "type": "gene", + "text": "The IgA deficiency is combined with the IgE one .", + "entities": [ + "IgA", + "IgE" + ] + }, + { + "id": "12464", + "type": "gene", + "text": "Two estrogen receptor ( ER ) isoforms with different estrogen dependencies are generated from the trout ER gene .", + "entities": [ + "estrogen receptor", + "ER", + "trout ER gene" + ] + }, + { + "id": "12465", + "type": "gene", + "text": "The N - terminus of another open reading frame was found 3 ' from nifA and tentatively identified as nifB by amino acid sequence comparison .", + "entities": [ + "nifA", + "nifB" + ] + }, + { + "id": "12466", + "type": "gene", + "text": "This regulation could not be appreciably modified by enhanced expression of STAT proteins .", + "entities": [ + "STAT proteins" + ] + }, + { + "id": "12467", + "type": "gene", + "text": "Synthesis of antisense RNA and S phase - dependent binding of E2F complexes in intron 1 .", + "entities": [ + "E2F complexes" + ] + }, + { + "id": "12468", + "type": "gene", + "text": "Later in development , Tbx6 expression is restricted to presomitic , paraxial mesoderm and to the tail bud , which replaces the streak as the source of mesoderm .", + "entities": [ + "Tbx6" + ] + }, + { + "id": "12469", + "type": "gene", + "text": "We found that lung cancer tissues of positive 67Ga scan expressed TFR , but those of a negative scan did not .", + "entities": [ + "TFR" + ] + }, + { + "id": "12470", + "type": "gene", + "text": "The apparatus consists of an Am - 241 exciting source ( 300 mCi ) and pure Ge detector ( 50 mm2 X 5 mm ) for measuring K alpha fluorescent x - rays ( 28 . 3 and 28 . 6 KeV ) emitted from exited iodine .", + "entities": [] + }, + { + "id": "12471", + "type": "gene", + "text": "However , a clear difference exists between myoblasts and 10T1 / 2 cells ( and other non - muscle cell types ) in the chromatin structure of the chromosomal myoD core enhancer , suggesting that the myoD enhancer is repressed by epigenetic mechanisms in 10T1 / 2 cells .", + "entities": [ + "myoD core enhancer", + "myoD enhancer" + ] + }, + { + "id": "12472", + "type": "gene", + "text": "Patients who have undergone thyroidectomy for thyroid carcinoma are frequently subjected to periods of induced severe hypothyroidism in preparation for 131I whole body scanning and measurement of serum TG .", + "entities": [ + "TG" + ] + }, + { + "id": "12473", + "type": "gene", + "text": "Alison Bell Memorial Award .", + "entities": [] + }, + { + "id": "12474", + "type": "gene", + "text": "These results demonstrate that a class of proline - rich activator proteins and RNA polymerase II possess a common structural and functional component which can interact with the same target in the general transcription machinery .", + "entities": [ + "RNA polymerase II" + ] + }, + { + "id": "12475", + "type": "gene", + "text": "Malignant lymphoma is very heterogeneous in terms of its biological behavior .", + "entities": [] + }, + { + "id": "12476", + "type": "gene", + "text": "METHODS : The responses of a 31 - year - old woman with complex regional pain syndrome type I ( reflex sympathetic dystrophy ) to a thermal grill were evaluated before and after stellate ganglion block .", + "entities": [] + }, + { + "id": "12477", + "type": "gene", + "text": "The 2 kb of 5 ' - flanking region and the 1 . 1 kb of the entire sGTH alpha subunit coding region were sequenced from the genomic clone , sGTH alpha - G1 .", + "entities": [ + "sGTH alpha subunit", + "sGTH alpha - G1" + ] + }, + { + "id": "12478", + "type": "gene", + "text": "Northern - blot analysis of mRNA from Avicel - grown N . patriciarum showed that xynB hybridized to a 3 . 4 kb mRNA species .", + "entities": [ + "xynB" + ] + }, + { + "id": "12479", + "type": "gene", + "text": "Individual alcohol reaction profiles .", + "entities": [] + }, + { + "id": "12480", + "type": "gene", + "text": "Deaths stopped 11 hours after copper concentrations decreased below 0 . 2 ppm and signs of distress stopped in surviving pinfish by approximately 6 hours after the last death .", + "entities": [] + }, + { + "id": "12481", + "type": "gene", + "text": "In these cases , asbestos or erionite - tissue burden followed by fibrosis was frequently observed .", + "entities": [] + }, + { + "id": "12482", + "type": "gene", + "text": "Conversely , activation of Oct - 3 / 4 promoter by RAR : RXR heterodimers was completely abolished by EAR - 3 / COUP - TFI and by ARP - 1 / COUP - TFII .", + "entities": [ + "Oct - 3 / 4 promoter", + "RAR", + "RXR heterodimers", + "EAR - 3", + "COUP - TFI", + "ARP - 1", + "COUP - TFII" + ] + }, + { + "id": "12483", + "type": "gene", + "text": "Both increasing basal FSH and age were associated significantly with increased total gonadotrophin dose , and reduced number of oocytes collected and pregnancy rate .", + "entities": [ + "FSH", + "gonadotrophin" + ] + }, + { + "id": "12484", + "type": "gene", + "text": "Transgenic mice harboring the rat TnI - CAT fusion gene expressed the reporter specifically in the skeletal muscle .", + "entities": [ + "TnI", + "CAT" + ] + }, + { + "id": "12485", + "type": "gene", + "text": "The up - regulation of E - selectin , one of the adhesion molecules on the endothelium , is an important event in the mediation of the inflammatory response .", + "entities": [ + "E - selectin" + ] + }, + { + "id": "12486", + "type": "gene", + "text": "Mutational analysis of a DNA sequence involved in linking gene expression to the cell cycle .", + "entities": [] + }, + { + "id": "12487", + "type": "gene", + "text": "Experimentally in green monkeys , Syrian hamsters and white mice the authors studied the pathogenic properties of a new virus Issyk - Kul .", + "entities": [] + }, + { + "id": "12488", + "type": "gene", + "text": "PACAP mRNA was widely expressed in most human tissues ; in transfected cells , PACAP was diffusely expressed in the cytoplasm .", + "entities": [ + "PACAP mRNA", + "PACAP" + ] + }, + { + "id": "12489", + "type": "gene", + "text": "Multiple transcription start sites were revealed by primer extension analysis of the mouse gene , and transfection constructs containing the prospective promoter generated transcriptional activity comparable to that of the SV40 promoter .", + "entities": [ + "SV40 promoter" + ] + }, + { + "id": "12490", + "type": "gene", + "text": "Functional postnatal development of the rat primary visual cortex and the role of visual experience : dark rearing and monocular deprivation .", + "entities": [] + }, + { + "id": "12491", + "type": "gene", + "text": "The HPLC method involves an octadecylsilane column at 55 degrees C , a mixture of water - acetonitrile - orthophosphoric acid ( 779 : 220 : 1 , v / v ) as mobile phase and detection at 226 nm .", + "entities": [] + }, + { + "id": "12492", + "type": "gene", + "text": "Three patients with four renoureteral units have undergone single - stage reconstruction involving ureteroureterostomy and ipsilateral ureteroneocystostomy following temporary loop cutaneous ureterostomy .", + "entities": [] + }, + { + "id": "12493", + "type": "gene", + "text": "Transplantation of kidneys of juvenile donors in adult recipients .", + "entities": [] + }, + { + "id": "12494", + "type": "gene", + "text": "The regional blockade of H1R was observed mainly in the frontal , temporal and anterior cingulate cortices , and the intravenous administration of d - chlorpheniramine as a therapeutic dose ( 2 mg ) blocked over 60 % of H1R in the frontal cortices .", + "entities": [ + "H1R", + "H1R" + ] + }, + { + "id": "12495", + "type": "gene", + "text": "In the course of investigating the mechanisms by which OF5 and OF3 regulated CYP11A1 transcription , we found that OF5 and OF3 bound Sp1 and Sp3 in JEG - 3 cells .", + "entities": [ + "OF5", + "OF3", + "CYP11A1", + "OF5", + "OF3", + "Sp1", + "Sp3" + ] + }, + { + "id": "12496", + "type": "gene", + "text": "In PAV - 3 , the E1A region is located between 1 . 5 and 3 . 8 map units .", + "entities": [ + "E1A region" + ] + }, + { + "id": "12497", + "type": "gene", + "text": "Arachnoid cyst .", + "entities": [] + }, + { + "id": "12498", + "type": "gene", + "text": "Moritta ) and contains Bis - GMA .", + "entities": [] + }, + { + "id": "12499", + "type": "gene", + "text": "Protein phosphatase 2A is a critical regulator of protein kinase C zeta signaling targeted by SV40 small t to promote cell growth and NF - kappaB activation .", + "entities": [ + "Protein phosphatase 2A", + "protein kinase C zeta", + "SV40 small t", + "NF - kappaB" + ] + }, + { + "id": "12500", + "type": "gene", + "text": "The models accurately localized the common boundaries between the PBB and CN .", + "entities": [] + }, + { + "id": "12501", + "type": "gene", + "text": "The possibility of selective chemotherapy of progressive recurring ovarian carcinoma with the aid of cytodiagnosis and incorporation of tagged idoxuridine", + "entities": [] + }, + { + "id": "12502", + "type": "gene", + "text": "Snail mortality did not differ among the various treatment conditions .", + "entities": [] + }, + { + "id": "12503", + "type": "gene", + "text": "A Bub2p - dependent spindle checkpoint pathway regulates the Dbf2p kinase in budding yeast .", + "entities": [ + "Bub2p", + "Dbf2p kinase in budding yeast" + ] + }, + { + "id": "12504", + "type": "gene", + "text": "Its vasodilatory , anti - vasopressor , and platelet stabilizing effects could be expected to counteract the placental ischemia , hypertension and excessive coagulation that are seen in pre - eclampsia .", + "entities": [] + }, + { + "id": "12505", + "type": "gene", + "text": "The RF values correlated well with the angiographic semiquantitative scale of severity of aortal insufficiency ( r = 0 . 805 ; p less than 0 . 001 ) , although they enabled the authors only to make a partial differentiation of haemodynamically severe regurgitations and mild or insignificant ones .", + "entities": [] + }, + { + "id": "12506", + "type": "gene", + "text": "In order to identify and classify the basic CT appearances of interstitial pneumonia , radiologic - pathologic correlative study was performed using inflated and fixed lungs from autopsy and surgery .", + "entities": [] + }, + { + "id": "12507", + "type": "gene", + "text": "The effect of zinc deficiency on trace metals in the liver , spleen , kidney , pancreas and duodenum was investigated in the control and zinc - deficient rats at 17 days and 20 days of pregnancy .", + "entities": [] + }, + { + "id": "12508", + "type": "gene", + "text": "Selective macrophage inhibition abolishes warfarin - induced reduction of metastasis .", + "entities": [] + }, + { + "id": "12509", + "type": "gene", + "text": "Truncated ICSBP lacking the first 33 amino - terminal amino acids fails to bind to the ICS , indicating that at least part of the DNA binding domain is located within the well conserved amino terminus .", + "entities": [ + "Truncated ICSBP", + "ICS" + ] + }, + { + "id": "12510", + "type": "gene", + "text": "We found that multiple tumor suppressor genes ( e . g . , p53 , DCC , APC , MCC , BRCA1 , and WAF1 / CIP1 ) were inactivated at different frequencies via various mechanisms [ e . g . , loss of heterozygosity ( LOH ) , loss of expression ( LOE ) , mutation , and inactivation by cellular binding protein ] .", + "entities": [ + "p53", + "DCC", + "APC", + "MCC", + "BRCA1", + "WAF1", + "CIP1" + ] + }, + { + "id": "12511", + "type": "gene", + "text": "Anterior body pattern in Drosophila is specified by the graded distribution of the bicoid protein ( bcd ) , which activates subordinate genes in distinct anterior domains .", + "entities": [ + "bicoid protein", + "bcd" + ] + }, + { + "id": "12512", + "type": "gene", + "text": "Horvath , I .", + "entities": [] + }, + { + "id": "12513", + "type": "gene", + "text": "We discuss these results in terms of the influence that time and nutritional constraints have on odonate development patterns and fitness .", + "entities": [] + }, + { + "id": "12514", + "type": "gene", + "text": "Clinical applications of inhibition of beta - adrenergic receptors with propranolol .", + "entities": [ + "beta - adrenergic receptors" + ] + }, + { + "id": "12515", + "type": "gene", + "text": "Although MAP ( mitogen - activated protein ) kinases are implicated in cell proliferation and differentiation in many cell types , the role of MAP kinases in cardiac hypertrophy remains unclear .", + "entities": [ + "MAP ( mitogen - activated protein ) kinases", + "MAP kinases" + ] + }, + { + "id": "12516", + "type": "gene", + "text": "In concept II 62 patients were treated with selective vagotomy and pyloroplasty .", + "entities": [] + }, + { + "id": "12517", + "type": "gene", + "text": "During presentation of happy facial expressions , we detected a signal increase predominantly in the left anterior cingulate gyrus , bilateral posterior cingulate gyri , medial frontal cortex and right supramarginal gyrus , brain regions previously implicated in visuospatial and emotion processing tasks .", + "entities": [] + }, + { + "id": "12518", + "type": "gene", + "text": "Hepatitis - B vaccination in the elderly .", + "entities": [] + }, + { + "id": "12519", + "type": "gene", + "text": "This enhancer activates both the K19 and TK basal promoters in HeLa cells .", + "entities": [ + "K19", + "TK basal promoters" + ] + }, + { + "id": "12520", + "type": "gene", + "text": "A randomized mix of 180 sections ( 10 samples x 3 tissues x 3 stains x 2 ) gave 90 matched pairs .", + "entities": [] + }, + { + "id": "12521", + "type": "gene", + "text": "During sub - maximal exercise , DCR in the UT dogs decreased from a resting value of 4 . 08 + / - 0 . 18 mm Hg X ml - 1 X min - 1 to 1 . 91 + / - 0 . 17 mm Hg X ml - 1 X min - 1 at a workload of 6 . 4 kph ( speed ) / 16 % ( grade ) .", + "entities": [] + }, + { + "id": "12522", + "type": "gene", + "text": "Hprp3p is a 77 kDa protein , which is homologous to the Saccharomyces cerevisiae splicing factor Prp3p .", + "entities": [ + "Hprp3p", + "Saccharomyces cerevisiae splicing factor Prp3p" + ] + }, + { + "id": "12523", + "type": "gene", + "text": "According to the investigation , the recent burst of pseudoterranovosis in this area can be attributed to the increased presence of sea lions , which proliferate in the Arctic region , then migrate to the northern Japan Sea and eat the intermediate host fish .", + "entities": [] + }, + { + "id": "12524", + "type": "gene", + "text": "60 patients were entered into a randomised study comparing vindesine ( 3 mg / m2 / week ) plus interferon - alpha 2b ( 6 U / m2 3 times per week ) to vindesine alone or to interferon alone for the treatment of metastatic malignant melanoma .", + "entities": [ + "interferon - alpha 2b", + "interferon" + ] + }, + { + "id": "12525", + "type": "gene", + "text": "In this regard , we have recently observed that a constitutively active G protein - coupled receptor ( GPCR ) encoded by the Kaposi ' s sarcoma - associated herpes virus ( KSHV ) / human herpes virus 8 is oncogenic and stimulates angiogenesis by increasing the secretion of vascular endothelial growth factor ( VEGF ) , which is a key angiogenic stimulator and a critical mitogen for the development of Kaposi ' s sarcoma .", + "entities": [ + "G protein - coupled receptor", + "GPCR", + "vascular endothelial growth factor", + "VEGF" + ] + }, + { + "id": "12526", + "type": "gene", + "text": "The drug was given in a daily oral dose of 0 . 5 g / m2 , 3 . 5 h prior to each radiation treatment .", + "entities": [] + }, + { + "id": "12527", + "type": "gene", + "text": "They lack a predicted single stranded ( ss ) DNA binding motif that is unique the large terminase proteins in T4 gp17 , and that has been implicated in recognizing ssDNA regions in replicating and recombining T4DNA destined to be packaged .", + "entities": [ + "terminase proteins", + "T4 gp17" + ] + }, + { + "id": "12528", + "type": "gene", + "text": "The etiology , pathology , brain CT scan features , clinical manifestations and treatment of these accidents were discussed .", + "entities": [] + }, + { + "id": "12529", + "type": "gene", + "text": "Furthermore , plasma fibrinogen levels increased by a mean of 17 . 6 % , a potentially adverse effect of gemfibrozil that has not been previously reported .", + "entities": [ + "fibrinogen" + ] + }, + { + "id": "12530", + "type": "gene", + "text": "Motile nocardoid Actinomycetales .", + "entities": [] + }, + { + "id": "12531", + "type": "gene", + "text": "The interaction of U1 - 70K with the SRZ proteins is confirmed further in vitro using a blot overlay assay .", + "entities": [ + "U1 - 70K", + "SRZ proteins" + ] + }, + { + "id": "12532", + "type": "gene", + "text": "Skin cancers , followed by gastrointestinal tract and male genital system affected mostly older age patients .", + "entities": [] + }, + { + "id": "12533", + "type": "gene", + "text": "Relief from autoinhibition and a subsequent 10 - 60 - fold increase in V ( max ) have been observed upon N - SH2 domain engagement by a specific phosphotyrosyl ligand or upon deletion of the SH2 domains to yield the catalytic PTPase domain .", + "entities": [ + "N - SH2 domain", + "SH2 domains", + "PTPase domain" + ] + }, + { + "id": "12534", + "type": "gene", + "text": "Acute pancreatitis as a complication of polyarteritis nodosa .", + "entities": [] + }, + { + "id": "12535", + "type": "gene", + "text": "Two of these resulted in increased levels of the alpha subunit , and one caused a substitution of glycine for the aspartic acid residue at position 171 , in the N - terminal domain .", + "entities": [] + }, + { + "id": "12536", + "type": "gene", + "text": "Yeast mutants assigned to the pet complementation group G104 were found to lack alpha - ketoglutarate dehydrogenase activity as a result of mutations in the dihydrolipoyl transsuccinylase ( KE2 ) component of the complex .", + "entities": [ + "pet", + "alpha - ketoglutarate dehydrogenase", + "dihydrolipoyl transsuccinylase", + "KE2" + ] + }, + { + "id": "12537", + "type": "gene", + "text": "They contrast trends in fertility , life expectancy ratios , and gender differences in these countries with the Hispanic population of the United States .", + "entities": [] + }, + { + "id": "12538", + "type": "gene", + "text": "The secondary , but not the primary , antibody responses of male C57Bl / 6 mice were higher among mice housed alone compared to mice housed in groups ; differences were observed for both IgM and IgG anti - KLH antibodies .", + "entities": [ + "IgM", + "IgG anti - KLH antibodies" + ] + }, + { + "id": "12539", + "type": "gene", + "text": "CKII as a CD44 - associated serine kinase therefore may serve as an important molecule in a signaling cascade that produces a variety of cellular responses in MDA231 breast cancer cells .", + "entities": [ + "CKII", + "CD44 - associated serine kinase" + ] + }, + { + "id": "12540", + "type": "gene", + "text": "We also localized the Fra - 2 phosphorylation sites by MAPK to three threonine and three serine residues in the COOH - terminal region by means of site - directed mutagenesis and showed that the threonine residues were more susceptible to MAPK .", + "entities": [ + "Fra - 2 phosphorylation sites", + "MAPK", + "MAPK" + ] + }, + { + "id": "12541", + "type": "gene", + "text": "SSF experiments were carried out in bench - scale bioreactors ( equipped with CO2 and volatile organic traps ) containing a mixture of lignocellulosic materials and a radiolabeled pesticide .", + "entities": [] + }, + { + "id": "12542", + "type": "gene", + "text": "Sequence analysis of this 100 - bp Col2a1 enhancer revealed several sequence motifs similar to motifs present within the regulatory region of the link protein gene , another cartilage gene .", + "entities": [ + "Col2a1 enhancer", + "link protein gene" + ] + }, + { + "id": "12543", + "type": "gene", + "text": "In addition , the megabase region surrounding the dagA locus was mapped .", + "entities": [ + "dagA locus" + ] + }, + { + "id": "12544", + "type": "gene", + "text": "STUDY OBJECTIVE : This study assessed several methodological aspects related to the quality of published controlled clinical trials ( CCTs ) in relation to the participation of an epidemiologist / biostatistician ( E / B ) .", + "entities": [] + }, + { + "id": "12545", + "type": "gene", + "text": "BACKGROUND : Ischemic heart disease is the primary cause of morbidity and mortality among diabetics , especially those who became ill at a young age .", + "entities": [] + }, + { + "id": "12546", + "type": "gene", + "text": "CONCLUSION : These findings imply that eotaxin either is mechanistically involved in acute asthma or serves as a biomarker for activity of the CCR3 receptor ligand system , which is functionally linked to asthma .", + "entities": [ + "CCR3 receptor ligand" + ] + }, + { + "id": "12547", + "type": "gene", + "text": "Some artificial promoter constructs containing multiple Sp1 sites were highly responsive to ethanol , but others were not , suggesting that the organization of the proximal promoter region was an additional factor that affected the ethanol response .", + "entities": [ + "Sp1 sites" + ] + }, + { + "id": "12548", + "type": "gene", + "text": "Moreover , expression of antisense Ha - Ras or dominant negative Raf - 1 abrogated the mitogenic effect of TGF - beta1 in TSU - Pr1 , and the TGF - beta1 inhibition of DU145 was switched to stimulation by V12Ha - Ras transfection .", + "entities": [ + "antisense Ha - Ras", + "dominant negative Raf - 1", + "TGF - beta1", + "TGF - beta1", + "V12Ha - Ras" + ] + }, + { + "id": "12549", + "type": "gene", + "text": "Unlike most other members of the Bcl - 2 family , BAD ( Bcl - xL / Bcl - 2 associated death promoter ) , a death enhancer , has no C - terminal transmembrane domain for targeting to the outer mitochondrial membrane and nuclear envelope .", + "entities": [ + "Bcl - 2 family", + "BAD", + "Bcl - xL / Bcl - 2 associated death promoter", + "death enhancer" + ] + }, + { + "id": "12550", + "type": "gene", + "text": "Cicatricial pemphigoid is an autoimmune systemic disease characterized by chronic conjunctival cicatrization .", + "entities": [] + }, + { + "id": "12551", + "type": "gene", + "text": "The opioid antagonist naltrexone ( 0 . 01 - 1 . 0 mg / kg ) antagonized the discriminative stimulus effects of heroin , but naltrexone at doses up to 10 mg / kg had no effect on the discriminative stimulus effects of cocaine .", + "entities": [] + }, + { + "id": "12552", + "type": "gene", + "text": "Similar clinical evaluation of an obligate carrier revealed no ocular abnormalities .", + "entities": [] + }, + { + "id": "12553", + "type": "gene", + "text": "Serum levels of albumin , globulin , and coagulation protein activity were measured preshock , postshock , and daily for 3 days ; skin lymph levels were measured on Day 3 .", + "entities": [ + "albumin", + "globulin", + "coagulation protein" + ] + }, + { + "id": "12554", + "type": "gene", + "text": "Lead fixation in dogs achieved with RF energy .", + "entities": [] + }, + { + "id": "12555", + "type": "gene", + "text": "Tumor necrosis factor - alpha ( TNF alpha ) , a proinflammatory cytokine , inhibits cAMP - stimulated testosterone production in mouse Leydig cells .", + "entities": [ + "Tumor necrosis factor - alpha", + "TNF alpha" + ] + }, + { + "id": "12556", + "type": "gene", + "text": "The carcass of a great horned owl ( Bubo virginianus ) , which had been found moribund in southern Ontario , was presented for necropsy .", + "entities": [] + }, + { + "id": "12557", + "type": "gene", + "text": "The spleen rate of about 600 villagers of RK I examined was 54 . 3 % and the parasite rate 13 . 2 % before the drug intervention .", + "entities": [] + }, + { + "id": "12558", + "type": "gene", + "text": "We established the radiosensitive cell line SX9 from mammary carcinoma cell line FM3A .", + "entities": [] + }, + { + "id": "12559", + "type": "gene", + "text": "These thyroid hormone changes may be mediated in part by cytokines or other inflammatory mediators , acting at the level of the hypothalamus and pituitary gland , the thyroid gland , and the hepatic deiodinase system .", + "entities": [ + "hepatic deiodinase" + ] + }, + { + "id": "12560", + "type": "gene", + "text": "Although YopH is a highly active PTP , it preferentially targets a subset of tyrosine - phosphorylated proteins in host cells , including p130Cas .", + "entities": [ + "YopH", + "PTP", + "p130Cas" + ] + }, + { + "id": "12561", + "type": "gene", + "text": "Regulation of yeast LEU2 .", + "entities": [ + "yeast LEU2" + ] + }, + { + "id": "12562", + "type": "gene", + "text": "In the long term , questions still remain about whether pre - dialysis rHu EPO either speeds up or delays the onset of dialysis .", + "entities": [ + "rHu EPO" + ] + }, + { + "id": "12563", + "type": "gene", + "text": "Positive genetic selections for inhibition of cyclin / CDK function were characterized using the E . coli neo and yeast LEU2 genes .", + "entities": [ + "cyclin", + "CDK", + "E . coli neo", + "yeast LEU2 genes" + ] + }, + { + "id": "12564", + "type": "gene", + "text": "The core promoter of human thioredoxin reductase 1 : cloning , transcriptional activity , and Oct - 1 , Sp1 , and Sp3 binding reveal a housekeeping - type promoter for the AU - rich element - regulated gene .", + "entities": [ + "human thioredoxin reductase 1", + "Oct - 1", + "Sp1", + "Sp3" + ] + }, + { + "id": "12565", + "type": "gene", + "text": "A novel gene designated cmr , which mapped to 18 . 8 min of the Escherichia coli K - 12 genome , was shown to mediate resistance to chloramphenicol when it was expressed from a multicopy vector .", + "entities": [ + "cmr" + ] + }, + { + "id": "12566", + "type": "gene", + "text": "The results obtained tend to prove that the reticuloendothelial system mainly participated in beryllium retention .", + "entities": [] + }, + { + "id": "12567", + "type": "gene", + "text": "Strontium nitrate mixed with glycolic acid , in comparison with glycolic acid alone , markedly ( p < 0 . 01 ) shortened the duration of the irritation sensation from 24 . 4 + / - 4 . 1 ( mean + / - SEM ) min to 8 . 9 + / - 3 . 7 ( mean + / - SEM ) min , and significantly ( p < 0 . 05 ) reduced the mean magnitude of the irritation sensation at all time points ( overall ) .", + "entities": [] + }, + { + "id": "12568", + "type": "gene", + "text": "After the application of RS 86 , REM latency was shortened in all groups under investigation .", + "entities": [] + }, + { + "id": "12569", + "type": "gene", + "text": "This study is a further and more extensive validation of the clinician rated NIMH - LCM - p .", + "entities": [] + }, + { + "id": "12570", + "type": "gene", + "text": "Contractile responses to norepinephrine , serotonin and potassium ( K + ) and relaxant responses to isoproterenol and papaverine were studied in vitro with spirally cut thoracic aortic strips from aortic coarcted hypertensive rats ( AHR ) 2 , 6 , 14 and 28 days postoperatively and compared to time - matched , sham - operated normotensive controls .", + "entities": [] + }, + { + "id": "12571", + "type": "gene", + "text": "Flow cytomery was used for cell cycle analysis .", + "entities": [] + }, + { + "id": "12572", + "type": "gene", + "text": "When examined as adults ( 8 weeks old ) , the external genitalia of TA - exposed offspring were normal .", + "entities": [] + }, + { + "id": "12573", + "type": "gene", + "text": "The patient underwent two intracytoplasmic sperm injection cycles with thawed epididymal spermatozoa , in which , due to a pharmacist ' s mistake , ovarian stimulation was carried out by a combination of long - acting gonadotrophin - releasing hormone agonist ( leuprolide depot ) and gonadotrophins .", + "entities": [ + "gonadotrophin - releasing hormone", + "gonadotrophins" + ] + } +] \ No newline at end of file