[ { "id": "3550", "type": "gene", "text": "To study the significance of these domains and the overall evolutionary conservation of the gene , the homolog from Drosophila melanogaster was isolated by low stringency hybridizations using two flanking probes of the human ERCC3 cDNA .", "entities": [ "human ERCC3 cDNA" ] }, { "id": "3690", "type": "gene", "text": "The emerging complexity of the 5 ' regulatory region of the GH receptor gene was emphasised by the observation that probes derived from exon 1B and the distal 3 ' intron boundary do not hybridise with previously cloned genomic sequences that span the liver - specific P1 promoter and exon 2 .", "entities": [ "GH receptor gene" ] }, { "id": "5705", "type": "gene", "text": "The number of crystalline deposits is less in the advanced atrophic areas of the RPE - choriocapillaris complex .", "entities": [] }, { "id": "8973", "type": "gene", "text": "The value of different sources of nitrogen in diets for the early - weaned calf .", "entities": [] }, { "id": "12152", "type": "gene", "text": "This lack of correlation may be due to variations in the metabolic activity of the endometriotic implants present at different stages of the disease .", "entities": [] }, { "id": "2693", "type": "gene", "text": "A new instrument has been designed for freeze - fracturing of biological material in ultra high vacuum .", "entities": [] }, { "id": "9036", "type": "gene", "text": "The term endovascular papillary haemangioma is suggested .", "entities": [] }, { "id": "7289", "type": "gene", "text": "National certification : a vital component of quality assurance .", "entities": [] }, { "id": "9263", "type": "gene", "text": "The Laser Scanning Ophthalmoscope enables a fundus - based examination and therefore allows exact comparison between morphologic appearance and corresponding function .", "entities": [] }, { "id": "7786", "type": "gene", "text": "The plasmid shuffle technique was used to replace the wild - type gene with the mutant form , resulting in failure of the yeast cells to grow .", "entities": [] }, { "id": "4240", "type": "gene", "text": "His HC II activity and antigen levels were 49 % and 50 % , respectively , and his daughter also showed similar low levels .", "entities": [ "HC II" ] }, { "id": "7145", "type": "gene", "text": "Most of the prepeptide portion of the precursor polypeptide is encoded by the next three exons , and the mature form of IL - 1 alpha is encoded by the remaining three exons .", "entities": [ "IL - 1 alpha" ] }, { "id": "11562", "type": "gene", "text": "Endothelial cell seeding .", "entities": [] }, { "id": "6702", "type": "gene", "text": "The bZP2 cDNA ( 115 - 1914 nt , 1 . 8 kb ) , excluding sequences coding for N - terminal signal sequence and C - terminal transmembranelike domain , was PCR amplified and Sac1 - Sal1 restricted fragment cloned in frame downstream of the T5 promoter under the lac operator control in a pQE - 30 vector .", "entities": [ "bZP2 cDNA ( 115 - 1914 nt , 1 . 8 kb )", "Sac1", "Sal1", "lac operator" ] }, { "id": "2677", "type": "gene", "text": "UGA codon position affects the efficiency of selenocysteine incorporation into glutathione peroxidase - 1 .", "entities": [ "glutathione peroxidase - 1" ] }, { "id": "9995", "type": "gene", "text": "Zn ( II ) coordination domain mutants of T4 gene 32 protein .", "entities": [ "T4 gene 32 protein" ] }, { "id": "9295", "type": "gene", "text": "The cause of death is often quite apparent from the pathological and toxicological findings ; however , the manner of death often gives the examining official some difficulty .", "entities": [] }, { "id": "11078", "type": "gene", "text": "A significant correlation between a number of functional parameters of gastric secretion , incretion and histological changes of gastric mucosa was found in patients with chronic gastritis .", "entities": [] }, { "id": "6927", "type": "gene", "text": "Disruption of re - replication control by overexpression of human ORC1 in fission yeast .", "entities": [ "human ORC1" ] }, { "id": "6267", "type": "gene", "text": "Structure and regulation of a nuclear gene in Saccharomyces cerevisiae that specifies MRP13 , a protein of the small subunit of the mitochondrial ribosome .", "entities": [ "MRP13" ] }, { "id": "8981", "type": "gene", "text": "To determine the relationship of these viruses , the complete DNA sequence of KV consisting of 4754 bp was determined .", "entities": [] }, { "id": "9086", "type": "gene", "text": "Initial experience with a serotonin agonist .", "entities": [] }, { "id": "516", "type": "gene", "text": "The two mouse lines carrying the unfragmented Hnf3g - lacZ YAC showed tissue - specific , copy number - dependent and position - independent expression , proving that 170 kb of the Hnf3g locus contain all elements important in the regulation of Hnf3g .", "entities": [ "Hnf3g", "lacZ", "Hnf3g", "Hnf3g" ] }, { "id": "5699", "type": "gene", "text": "Biliary - enteric fistulas", "entities": [] }, { "id": "4457", "type": "gene", "text": "We found in the control subjects rCBF increases in regions associated with the meso - striatal and meso - corticolimbic circuits in response to both monetary reward and nonmonetary reinforcement .", "entities": [] }, { "id": "6629", "type": "gene", "text": "In addition , we also show that cdk7 may phosphorylate the carboxy - terminal domain ( CTD ) of RNA pol II in the absence of promoter opening .", "entities": [ "cdk7", "RNA pol II" ] }, { "id": "12456", "type": "gene", "text": "CONCLUSIONS : Significant elevations of IL - 1alpha and IL - 1beta occur in patients with bacterial cystitis and microscopic hematuria .", "entities": [ "IL - 1alpha", "IL - 1beta" ] }, { "id": "4270", "type": "gene", "text": "Degradation of the soybean ribulose - 1 , 5 - bisphosphate carboxylase small - subunit mRNA , SRS4 , initiates with endonucleolytic cleavage .", "entities": [ "soybean ribulose - 1 , 5 - bisphosphate carboxylase small - subunit mRNA", "SRS4" ] }, { "id": "509", "type": "gene", "text": "M - Ras interacted poorly in a yeast two - hybrid assay with multiple Ras effectors , including c - Raf - 1 , A - Raf , B - Raf , phosphoinositol - 3 kinase delta , RalGDS , and Rin1 .", "entities": [ "M - Ras", "Ras", "c - Raf - 1", "A - Raf", "B - Raf", "phosphoinositol - 3 kinase delta", "RalGDS", "Rin1" ] }, { "id": "5501", "type": "gene", "text": "Electrochemical detection of depressed circulating levels of vitamin K1 in osteoporosis .", "entities": [] }, { "id": "9481", "type": "gene", "text": "It is related to a variety of mammalian Golgi - associated proteins and to the yeast Uso1p , an essential protein involved in docking of endoplasmic reticulum - derived vesicles to the cis - Golgi .", "entities": [ "Uso1p" ] }, { "id": "10419", "type": "gene", "text": "The coexpression of full - length expression constructs for both DBP and hepatic leukemia factor resulted in a dramatic increase in activation mediated by the GAL4 - DBP fusion proteins , suggesting the involvement of a regulated coactivator in this process .", "entities": [ "DBP", "hepatic leukemia factor", "GAL4", "DBP" ] }, { "id": "2054", "type": "gene", "text": "Using an RNase H protection assay and specific blocking oligonucleotides , we find that recognition of the 5 ' splice - site ( 5 ' ss ) and branchpoint sequence ( BPS ) elements by U11 and U12 snRNPs , respectively , displays strong cooperativity , requiring both sites in the pre - mRNA substrate for efficient complex formation .", "entities": [ "RNase H", "U11", "U12 snRNPs" ] }, { "id": "6980", "type": "gene", "text": "We propose that Mad and Medea encode rate - limiting components integral to dpp pathways throughout development .", "entities": [ "Mad", "Medea", "dpp" ] }, { "id": "10714", "type": "gene", "text": "Plasma thromboxane B2 levels in the older group were about double those in younger piglets .", "entities": [] }, { "id": "8899", "type": "gene", "text": "The newly defined region contains an intron that may be alternatively spliced and seven polyadenylation signal sequences .", "entities": [] }, { "id": "5929", "type": "gene", "text": "In rats , we examined the effect of an omentum wrapping on the vascularization of the trachea and on regeneration of the mucosal epithelium in the very early stage after free tracheal grafting .", "entities": [] }, { "id": "2404", "type": "gene", "text": "The IE0 gene product also transactivated the IE1 promoter but did not affect expression from its own promoter .", "entities": [ "IE0 gene", "IE1 promoter" ] }, { "id": "1764", "type": "gene", "text": "PCR / Southern blot analysis of human kidney cDNA using primers flanking the hKID coding sequence revealed expression of a full - length mRNA and short transcripts with partial exon 1 and partial exon 4 deletions .", "entities": [ "hKID coding sequence" ] }, { "id": "11553", "type": "gene", "text": "These mutants grow normally in 3T6 mouse fibroblast cells , and they do not complement the wild - type virus in coinfection experiments of C2 myoblasts .", "entities": [] }, { "id": "11774", "type": "gene", "text": "Data management in practice - based research .", "entities": [] }, { "id": "3422", "type": "gene", "text": "The electromyographically recorded responses consisted of an early R1 response in the orbicularis oculi muscle ipsilateral to the side of stimulation , a bilateral late response ( ipsilateral R2 and contralateral Rc ) and a third , R3 response , in the ipsilateral orbicularis oculi muscle .", "entities": [] }, { "id": "3569", "type": "gene", "text": "Urological complications are frequent during and after the treatment of gynecological malignancy .", "entities": [] }, { "id": "4546", "type": "gene", "text": "This effect was abolished once the EM motif in the promoter - reporter construct was mutated , thus suggesting that the synergistic transactivation function of the TEF - 1 - Max heterotypic complex is mediated through binding of the complex to the EM motif .", "entities": [ "TEF - 1", "Max" ] }, { "id": "2057", "type": "gene", "text": "The mHIF - 1 alpha structural gene is composed of 15 exons .", "entities": [ "mHIF - 1 alpha structural gene" ] }, { "id": "9113", "type": "gene", "text": "Cardiovascular and adrenal medullo - sympathetic reactions to acute tobacco poisoning", "entities": [] }, { "id": "5787", "type": "gene", "text": "Reperfusion caused a transient reduction in lactate production and a significant increase in LDH release .", "entities": [ "LDH" ] }, { "id": "10372", "type": "gene", "text": "The UCR core sequence , CGCCATTTT , binds a ubiquitous nuclear factor and mediates negative regulation of MuLV promoter activity .", "entities": [] }, { "id": "10147", "type": "gene", "text": "Using a high - copy suppression strategy , we have identified a yeast gene ( UBS1 ) whose elevated expression suppresses the conditional cell cycle defects associated with cdc34 mutations .", "entities": [ "UBS1", "cdc34" ] }, { "id": "5231", "type": "gene", "text": "In vitro , Arix and NBPhox form DNA - independent multimers and exhibit cooperative binding to the DB1 regulatory element , which contains two homeodomain recognition sites .", "entities": [ "Arix", "NBPhox", "DB1 regulatory element", "homeodomain recognition sites" ] }, { "id": "8594", "type": "gene", "text": "These \" nucleocapsid - like \" structures were readily purified by density gradient centrifugation .", "entities": [] }, { "id": "1422", "type": "gene", "text": "Hypoglycemic action of \" he xiang zhuang qi gong \" and its mechanism on diabetes mellitus", "entities": [] }, { "id": "799", "type": "gene", "text": "Fluorescence in situ hybridization of metaphase spreads of chromosome 8 , containing hybrid cell line 706 - B6 clone 17 ( CL - 17 ) with cosmid c101F1 , placed the 9804 gene close to the telomere at 8q24 . 3 .", "entities": [ "9804 gene" ] }, { "id": "6148", "type": "gene", "text": "Selective activation of adrenaline secretion by the rat adrenal in neuroglycopenia detected via microdialysis", "entities": [] }, { "id": "9098", "type": "gene", "text": "The response of serum GH to arginine infusion was normal , while that to insulin - induced hypoglycemia was poor .", "entities": [ "serum GH", "insulin" ] }, { "id": "12495", "type": "gene", "text": "In the course of investigating the mechanisms by which OF5 and OF3 regulated CYP11A1 transcription , we found that OF5 and OF3 bound Sp1 and Sp3 in JEG - 3 cells .", "entities": [ "OF5", "OF3", "CYP11A1", "OF5", "OF3", "Sp1", "Sp3" ] }, { "id": "1678", "type": "gene", "text": "In one glioblastoma cell line , a Shc - associated p190 was identified as the activated PDGFR .", "entities": [ "Shc", "p190", "PDGFR" ] }, { "id": "2893", "type": "gene", "text": "However , with the alpha1 antagonist prazosin ( 5 x 10 ( - 8 ) - 5 x 10 ( - 7 ) M ) , no relaxation occurred .", "entities": [] }, { "id": "11655", "type": "gene", "text": "Furthermore , beta 2 - adrenoceptor sensitivity appears to be unaltered in BHT .", "entities": [ "beta 2 - adrenoceptor" ] }, { "id": "192", "type": "gene", "text": "In mitogen - stimulated splenocytes , Gfi - 1 expression begins to rise at 12 h after stimulation and reaches very high levels after 50 h , suggesting that it may be functionally involved in events occurring after the interaction of IL - 2 with its receptor , perhaps during the transition from the G1 to the S phase of the cell cycle .", "entities": [ "Gfi - 1", "IL - 2" ] }, { "id": "8476", "type": "gene", "text": "Deformities of the tip of the olecranon and of the coronoid process are also described ( De Palma 1956 , Jordan 1958 , Ahlberg 1965 , Weseloh 1973 ) .", "entities": [] }, { "id": "3244", "type": "gene", "text": "DAF16 is known to be a component of a signaling pathway that has been partially dissected genetically and includes homologues of the insulin / IGF - 1 receptor , PtdIns 3 - kinase and PKB .", "entities": [ "DAF16", "insulin", "IGF - 1 receptor", "PtdIns 3 - kinase", "PKB" ] }, { "id": "11630", "type": "gene", "text": "Ischemic heart disease evaluated by exercise stress thallium - 201 myocardial scintigraphy : a comparison of SPECT and bull ' s eye display", "entities": [] }, { "id": "6402", "type": "gene", "text": "The differentiation and maintenance of a neurotransmitter phenotype is guided by the interaction of exogenous cues with intrinsic genetic machinery .", "entities": [] }, { "id": "10120", "type": "gene", "text": "According to the literature , second malignant epithelial tumours are , in contrast to mesenchymal tumours such as osteosarcoma , very rare in retinoblastoma survivors .", "entities": [] }, { "id": "9852", "type": "gene", "text": "GlcNAc - and GlcNAc2 - PP - Dolichol biosynthesis could be shown with isolated S . cerevisiae membranes from cells harboring the recombinant plasmid and grown on glucose thus suppressing transcription of the endogenous gene .", "entities": [] }, { "id": "8479", "type": "gene", "text": "JNK is additionally regulated by the Ras - related G proteins Rac and Cdc42 .", "entities": [ "JNK", "Ras", "Rac", "Cdc42" ] }, { "id": "1581", "type": "gene", "text": "This study tested the hypothesis that sodium channel blocking drugs selectively prolong the late potential , or terminal low amplitude signal , portion of the signal - averaged QRS complex and that prolongation of the late potential would correlate with slowing of ventricular tachycardia .", "entities": [] }, { "id": "3825", "type": "gene", "text": "Molecular cloning of mouse thioredoxin reductases .", "entities": [ "mouse thioredoxin reductases" ] }, { "id": "10925", "type": "gene", "text": "To investigate the molecular mechanisms of this Tax - mediated inhibition , we analyzed its effect on the transcriptional activity of the myogenic MyoD protein , which was used as a paradigm of bHLH factors .", "entities": [ "Tax", "MyoD protein", "bHLH factors" ] }, { "id": "12160", "type": "gene", "text": "The mutants were obtained by substitution into a molecular clone of M - MuLV DNA by DNA from two acutely transforming viruses , Ableson MuLV ( Ab - MuLV ) and Moloney murine sarcoma virus ( M - MSV ) .", "entities": [] }, { "id": "9746", "type": "gene", "text": "This compares favorably to results of similarly sized melanomas treated by enucleation .", "entities": [] }, { "id": "2678", "type": "gene", "text": "The IC50 values for rat and dog urinary bladder were 3 . 9 x 10 ( - 6 ) M and 3 . 8 x 10 ( - 6 ) M , respectively .", "entities": [] }, { "id": "6733", "type": "gene", "text": "31 , 1997 , 40 patients had died ( 35 in the ERA - II group and 5 in the ERA - III group ) , for a crude mortality rate of 8 . 0 % .", "entities": [] }, { "id": "3467", "type": "gene", "text": "Vitrectomy with an alternative instrument system .", "entities": [] }, { "id": "6830", "type": "gene", "text": "The PC2 protein also shows great similarity to the incomplete NH2 - terminal sequence of the human furin gene product , a putative membrane - inserted receptor - like molecule .", "entities": [ "PC2 protein", "human furin gene product" ] }, { "id": "10064", "type": "gene", "text": "These data indicate that although 218leu retains normal transactivation activity on a p53 promoter in yeast at physiological temperatures , it is not capable of normal p53 function in the presence of a 248trp allele in SNU - C5 cells .", "entities": [ "p53 promoter", "p53", "248trp allele" ] }, { "id": "9814", "type": "gene", "text": "This is predicted to encode a 315 - residue protein containing seven hydrophobic helical regions and a 17 amino acid motif characteristic of the R7G family of G - protein coupled membrane - bound receptors .", "entities": [ "R7G family", "G - protein coupled membrane - bound receptors" ] }, { "id": "2506", "type": "gene", "text": "Both antidepressants elevated the pain threshold acutely , while pretreatment with pCPA largely blocked the analgesia .", "entities": [] }, { "id": "2758", "type": "gene", "text": "The syncytial microvillous projections seemed to be more numerous and longer in CNF , otherwise the structure of the trophoblastic layer of the villi and the lining of the subtrophoblastic vessels were identical in CNF and controls .", "entities": [] }, { "id": "5269", "type": "gene", "text": "Crystal structure of an oligomer of proteolytic zymogens : detailed conformational analysis of the bovine ternary complex and implications for their activation .", "entities": [] }, { "id": "6238", "type": "gene", "text": "Fifty - six semen samples were included in this study ; 18 were subnormal ( G1 ) and 38 were normal ( G2 ) based on World Health Organization criteria , except for morphology , which was evaluated according to strict criteria .", "entities": [] }, { "id": "841", "type": "gene", "text": "Interplane coupling in the superconductor Y2Ba4Cu7O15 as revealed by NQR spin - echo double resonance .", "entities": [] }, { "id": "11398", "type": "gene", "text": "Plasma lactoferrin and the blood count of polynuclear neutrophils", "entities": [ "Plasma lactoferrin" ] }, { "id": "332", "type": "gene", "text": "Tilmicosin is a novel macrolide antibiotic developed for exclusive use in veterinary medicine .", "entities": [] }, { "id": "6510", "type": "gene", "text": "Although antisperm antibodies are associated with infertility , many hospital laboratories do not test for these antibodies .", "entities": [] }, { "id": "3523", "type": "gene", "text": "Tyrosine 1356 forms a multisubstrate binding site for the Grb2 and Shc adaptor proteins , the p85 subunit of phosphatidylinositol 3 ' - kinase , phospholipase Cgamma , and a phosphatase , SHP2 .", "entities": [ "Grb2", "Shc adaptor proteins", "p85 subunit", "phosphatidylinositol 3 ' - kinase", "phospholipase Cgamma", "SHP2" ] }, { "id": "10804", "type": "gene", "text": "Effects of dioxins on thyroid function in newborn babies .", "entities": [] }, { "id": "5481", "type": "gene", "text": "Penicillin acylase ( PA ) from Escherichia coli ATCC11105 is a periplasmic heterodimer consisting of a 24 kDa small subunit and a 65 kDa large subunit .", "entities": [ "Penicillin acylase", "PA" ] }, { "id": "2950", "type": "gene", "text": "Increased granulocyte - colony stimulating factor ( G - CSF ) levels in neonates with perinatal complications .", "entities": [ "granulocyte - colony stimulating factor", "G - CSF" ] }, { "id": "10153", "type": "gene", "text": "We studied the role of prostaglandins in acid - induced esophagitis and the associated LES hypotension by simultaneous treatment of some animals with indomethacin ( 150 micrograms / kg intravenous ) , a specific inhibitor of prostaglandin synthesis , either during production of esophagitis or during recovery .", "entities": [] }, { "id": "10919", "type": "gene", "text": "During exercise K + is released from contracting muscle and plasma K + concentration rises .", "entities": [] }, { "id": "12133", "type": "gene", "text": "The findings are compatible with the idea that the genes encoding PDGF receptors in glioma cells are regulated in concert with other genes , the expression of which may reflect the developmental program of normal glia cell lineages .", "entities": [ "PDGF receptors" ] }, { "id": "11832", "type": "gene", "text": "A high - frequency restriction fragment length polymorphism was evident in the DNA from 29 unrelated individuals using the enzyme BglII .", "entities": [ "BglII" ] }, { "id": "10475", "type": "gene", "text": "A study was conducted of a human male who had inhaled a mixture of 241Am and Pu .", "entities": [] }, { "id": "131", "type": "gene", "text": "Since 1970 the frequency of potassium - induced ulceration has been low - - 3 cases per 100 000 patient - years of slow - release tablet use .", "entities": [] }, { "id": "10616", "type": "gene", "text": "Cheung and S .", "entities": [] }, { "id": "1079", "type": "gene", "text": "Number and size of the myelin structures in the pneumocytes typ II increased simultaneously .", "entities": [] }, { "id": "9786", "type": "gene", "text": "Treatment of hypertension with a combination of the adrenergic beta receptor blockader , obsidan , and the vasodilator , apressin", "entities": [ "adrenergic beta receptor" ] }, { "id": "5508", "type": "gene", "text": "Structural organization and expression of the mouse estrogen receptor .", "entities": [ "mouse estrogen receptor" ] }, { "id": "7683", "type": "gene", "text": "Here we show that epidermal growth factor or platelet - derived growth factor stimulation of intact human or murine cells leads to phosphorylation of Nck protein on tyrosine , serine , and threonine residues .", "entities": [ "epidermal growth factor", "platelet - derived growth factor", "Nck protein" ] }, { "id": "4823", "type": "gene", "text": "d ( G12 - G13 - A14 - A15 - G16 - T17 - G18 - A19 - G20 + + + - A21 - G22 ) ( designated ( B [ g ] C ) dA . dT 11 - mer duplex ) , has been studied using structural information derived from NMR data in combination with molecular dynamics ( MD ) calculations .", "entities": [] }, { "id": "139", "type": "gene", "text": "In gel mobility shift assays , factors present in nuclear extracts derived from differentiated osteoblast bound to oligonucleotide probes containing the E - box 1 and E - box 2 elements .", "entities": [] }, { "id": "9023", "type": "gene", "text": "Of these 179 samples , Mobiluncus SP was observed in 35 ( 19 . 6 % ) using Gram staining and in 18 ( 10 . 1 % ) this microorganism was isolated in agar RLK and anaerobic atmosphere .", "entities": [] }, { "id": "12432", "type": "gene", "text": "yAP180 proteins and Pan1p , like actin , localize to peripheral patches along the plasma membrane .", "entities": [ "yAP180 proteins", "Pan1p", "actin" ] }, { "id": "5974", "type": "gene", "text": "OBJECTIVES : The objective of this review was to compare the effectiveness , safety and acceptability of the diaphragm with and without spermicide .", "entities": [] }, { "id": "11782", "type": "gene", "text": "These viruses depend on the host cell machinery for their existence , and interference with these processes typically interferes with other important host physiology .", "entities": [] }, { "id": "8441", "type": "gene", "text": "Morphine injected into the lateral ventricle of the rat produced unilateral analgesia in the formalin test , which involves continuous , moderate pain .", "entities": [] }, { "id": "859", "type": "gene", "text": "It acts on Cdks in the G1 and S phases of the cell cycle , and also binds to proliferating cell nuclear antigen ( PCNA ) , blocking DNA replication in vitro .", "entities": [ "Cdks", "proliferating cell nuclear antigen", "PCNA" ] }, { "id": "6020", "type": "gene", "text": "The alterations of 5 - HT and 5 - HIAA levels in several regions of the brain under the conditions examined may indicate that IDPN ' s neurotoxicity primarily affects 5 - HT - containing neurones .", "entities": [] }, { "id": "9432", "type": "gene", "text": "Atherosclerosis", "entities": [] }, { "id": "2379", "type": "gene", "text": "Parathyroid hormone regulation of bone sialoprotein ( BSP ) gene transcription is mediated through a pituitary - specific transcription factor - 1 ( Pit - 1 ) motif in the rat BSP gene promoter .", "entities": [ "Parathyroid hormone", "bone sialoprotein", "BSP", "pituitary - specific transcription factor - 1", "Pit - 1", "rat BSP gene promoter" ] }, { "id": "1552", "type": "gene", "text": "Human antitetanus serum : an unused wealth", "entities": [] }, { "id": "11763", "type": "gene", "text": "In addition , all three Opa proteins of C751 bind equally well to HeLa cells transfected with cDNA encoding the carcinoembryonic antigen [ CEA ( CD66e ) ] subgroup of the CD66 family , but show distinct tropism for CGM1 - ( CD66d ) and NCA ( CD66c ) - expressing cells .", "entities": [ "Opa proteins", "carcinoembryonic antigen", "CEA", "CD66e", "CD66 family", "CGM1", "CD66d", "NCA", "CD66c" ] }, { "id": "9316", "type": "gene", "text": "Sprague - Dawley newborn rats ( n = 85 ) breathed 100 % oxygen ( O2 ) or room air ( RA ) during the first 8 days of life , and then RA .", "entities": [] }, { "id": "3500", "type": "gene", "text": "Large T antigen was coimmunoprecipitated by antibodies to epitope - tagged TBP , endogenous TBP , hTAF ( II ) 100 , hTAF ( II ) 130 , and hTAF ( II ) 250 , under conditions where holo - TFIID would be precipitated .", "entities": [ "Large T antigen", "TBP", "TBP", "hTAF ( II ) 100", "hTAF ( II ) 130", "hTAF ( II ) 250", "holo - TFIID" ] }, { "id": "4324", "type": "gene", "text": "Accepting arbitrarily chosen limits of maximized errors of + / - 10 % , it could be shown that the system did not work acceptably when the mean carbon dioxide concentration was below 1 . 5 vol . % within the fresh gas flow rates ( 2 . 2 - - 7 . 7 1 min - 1 ) and the range of minute ventilation ( 4 - - 10 1 min - 1 ) employed .", "entities": [] }, { "id": "12166", "type": "gene", "text": "Control subjects ' evoked potentials ( EPs ) were characterized by an initial positivity in the 90 - 140 ms range ( P1 ) at the temporo - occipital site .", "entities": [] }, { "id": "11472", "type": "gene", "text": "In supine position , plasma ANP levels ranged from 12 pg / ml to 51 . 5 pg / ml , with an average level of 35 . 3 + / - 11 . 5 pg / ml .", "entities": [ "ANP" ] }, { "id": "6488", "type": "gene", "text": "Finally , profiling of a gcn4Delta mutant uncovered an alternative induction pathway operating at many Gcn4p target genes in histidine - starved cells .", "entities": [ "gcn4Delta mutant", "Gcn4p target genes" ] }, { "id": "3513", "type": "gene", "text": "The level of contamination in the wound can be determined with the rapid biopsy fixation technique .", "entities": [] }, { "id": "4700", "type": "gene", "text": "Quinone - binding domain and amino acid residues involved in quinone binding .", "entities": [] }, { "id": "7241", "type": "gene", "text": "No symptoms other than hot flush showed such significant correlation with plasma epinephrine or norepinephrine levels .", "entities": [] }, { "id": "6773", "type": "gene", "text": "Muscular pathology", "entities": [] }, { "id": "12329", "type": "gene", "text": "We established that the 2 . 6 kb mRNA V - 1 and the 2 . 3 kb GGT mRNA V - 2 derive , by alternate splicing , from a primary transcript initiated on a distal promoter on the rat GGT gene .", "entities": [ "GGT", "rat GGT gene" ] }, { "id": "7775", "type": "gene", "text": "Clinical evaluation of the Allergan Humphrey 500 autorefractor and the Nidek AR - 1000 autorefractor .", "entities": [] }, { "id": "4073", "type": "gene", "text": "Bandshift experiments demonstrate that BmHR3A binds specifically to RORE ( Retinoic acid - related Orphan receptor Response Element ) - like sequences in the promoters of both genes , thus suggesting a direct role for BmHR3A in regulating the expression of BmGATAbeta and ESP genes during vitellogenesis .", "entities": [ "BmHR3A", "RORE", "Retinoic acid - related Orphan receptor Response Element", "BmHR3A", "BmGATAbeta", "ESP genes" ] }, { "id": "12489", "type": "gene", "text": "Multiple transcription start sites were revealed by primer extension analysis of the mouse gene , and transfection constructs containing the prospective promoter generated transcriptional activity comparable to that of the SV40 promoter .", "entities": [ "SV40 promoter" ] }, { "id": "562", "type": "gene", "text": "Such transgenic plants should enable not only the mutational analysis of sequence elements within the replication origin region , but also the construction of a new generation of vectors for gene amplification in plants , based on a minimal virus replicon .", "entities": [] }, { "id": "6920", "type": "gene", "text": "In this study , the effect of acute administration of various doses of malathion via oral and dermal routes to mice and rats on serum levels of histamine was evaluated .", "entities": [] }, { "id": "2169", "type": "gene", "text": "We have partially sequenced the RAP74 protein from purified HeLa cells , cloned its complementary DNA and shown that its translation product can interact with RAP30 in vitro as well as in vivo .", "entities": [ "RAP74 protein", "RAP30" ] }, { "id": "8993", "type": "gene", "text": "Bilateral Charnley arthroplasty as a single procedure .", "entities": [] }, { "id": "8360", "type": "gene", "text": "Facioscapulohumeral muscular dystrophy ( FSHD ) is an autosomal dominant , neuromuscular disorder characterized by progressive weakness of muscles in the face , shoulder and upper arm .", "entities": [] }, { "id": "8743", "type": "gene", "text": "The eluting solvent was methanol - chloroform ( 10 + 90 ) at a flow rate of 2 . 0 ml / min .", "entities": [] }, { "id": "6234", "type": "gene", "text": "To determine whether interaction of arsenite with the hormone - binding domain results in receptor activation , COS - 1 cells were transiently cotransfected with the chimeric receptors GAL - ER , which contains the hormone - binding domain of ERalpha and the DNA - binding domain of the transcription factor GAL4 , and a GAL4 - responsive CAT reporter gene .", "entities": [ "chimeric receptors GAL - ER", "ERalpha", "GAL4", "GAL4", "CAT reporter gene" ] }, { "id": "10365", "type": "gene", "text": "Five of these eight patients in group II also received 8 - in - 1 chemotherapy .", "entities": [] }, { "id": "3597", "type": "gene", "text": "No significant correlations of peak VO2 were observed between the 3 tests .", "entities": [] }, { "id": "10901", "type": "gene", "text": "Interestingly , the IR5 ORF of EHV - 1 possesses a sequence of 13 amino acids ( CAYWCCLGHAFAC ) that is a perfect match to the consensus zinc finger motif ( C - X2 - 4 - C - X2 - 15 - C / H - X2 - 4 - C / H ) .", "entities": [ "IR5 ORF" ] }, { "id": "515", "type": "gene", "text": "Review : deterioration of glucose tolerance with age : the role of insulin resistance .", "entities": [ "insulin" ] }, { "id": "1944", "type": "gene", "text": "The transcription factor CHOP / GADD153 gene is induced by cellular stress and is involved in mediating apoptosis .", "entities": [ "CHOP", "GADD153" ] }, { "id": "11775", "type": "gene", "text": "The system , designed to exploit the relatively constant small intestine transit time , consists of a drug - containing core coated with a polymeric matrix formed by a channeling agent ( NaCl , mannitol , and Emdex ) and an inert polymer ( Eudragit RS100 ) .", "entities": [] }, { "id": "12112", "type": "gene", "text": "Differential expression and regulation by 20 - hydroxyecdysone of mosquito ultraspiracle isoforms .", "entities": [] }, { "id": "7057", "type": "gene", "text": "A second even more significant match to this E . coli region was found in the retroviral ribonuclease H ( RNase H ) domain , and corresponds precisely to a region that has been aligned by previous investigators with the E . coli RNase H , suggesting that Pol I helices O and P are homologous to helices A and D of the RNase H crystal structure , respectively .", "entities": [ "retroviral ribonuclease H", "RNase H", "E . coli RNase H", "Pol I", "RNase H" ] }, { "id": "2406", "type": "gene", "text": "Mutational analysis supports a role for multiple structural features in the C - terminal secretion signal of Escherichia coli haemolysin .", "entities": [ "Escherichia coli haemolysin" ] }, { "id": "7029", "type": "gene", "text": "Binding of cell type - specific nuclear proteins to the 5 ' - flanking region of maize C4 phosphoenolpyruvate carboxylase gene confers its differential transcription in mesophyll cells .", "entities": [ "maize C4 phosphoenolpyruvate carboxylase gene" ] }, { "id": "9764", "type": "gene", "text": "Thereafter , the aggregation rose to the initial 100 % value 4 h after drug application and remained at this level during the observation period . ( ABSTRACT TRUNCATED AT 250 WORDS )", "entities": [] }, { "id": "5123", "type": "gene", "text": "Despite the existence of 30 cysteine residues , carboxymethylation prevented the formation of most if not all disulfide bonds that otherwise occurred when the cells were sonicated .", "entities": [] }, { "id": "1974", "type": "gene", "text": "In ICU patients , the LIS related to the postoperative rise in IL - 6 level only , even though the rise in plasma concentrations of cytokines interrelated .", "entities": [ "IL - 6" ] }, { "id": "2968", "type": "gene", "text": "Results indicate that KNM - LU 335 differs from both human and chimpanzee M1s in relative distances ( measured in three dimensions ) between crown fissure termini .", "entities": [] }, { "id": "11867", "type": "gene", "text": "He was administered recombinant IFN alpha - 2b under the diagnosis of chronic hepatitis C .", "entities": [ "recombinant IFN alpha - 2b" ] }, { "id": "11844", "type": "gene", "text": "Some 8 . 8 kb of the Lactobacillus sake plasmid pCIM1 was sequenced , revealing eight tightly clustered open reading frames ( ORFs ) downstream from lasA , which encodes pre - lactocin S .", "entities": [ "lasA", "pre - lactocin S" ] }, { "id": "11631", "type": "gene", "text": "Baseline MBF in females was significantly ( P < 0 . 001 ) higher than in males .", "entities": [] }, { "id": "6979", "type": "gene", "text": "Promoter region of the transcriptional unit for human alpha 1 - chimaerin , a neuron - specific GTPase - activating protein for p21rac . alpha 1 - chimaerin is a neuron - specific GTPase - activating protein for p21rac , a protein involved in morphological events .", "entities": [ "human alpha 1 - chimaerin", "neuron - specific GTPase - activating protein", "p21rac", "alpha 1 - chimaerin", "neuron - specific GTPase - activating protein", "p21rac" ] }, { "id": "8009", "type": "gene", "text": "When a tumour is present nipple discharge is of little importance for the diagnosis and treatment .", "entities": [] }, { "id": "378", "type": "gene", "text": "Curing shrinkage and volumetric changes of resin - modified glass ionomer restorative materials .", "entities": [] }, { "id": "9379", "type": "gene", "text": "( iii ) In these cells , PKCbeta plays a unique Ras - independent role in mediating insulin but not EGF or other growth factor mitogenic signals .", "entities": [ "PKCbeta", "Ras", "insulin", "EGF" ] }, { "id": "7169", "type": "gene", "text": "Some users will willingly comply with management measures , other users will comply in response to education , but there will be another group who will only respond to enforcement activities .", "entities": [] }, { "id": "323", "type": "gene", "text": "The pia mater at the site of the entry of blood vessels into the central nervous system .", "entities": [] }, { "id": "12444", "type": "gene", "text": "Regression analyses identified 7 risk and 7 protective factors with minimal overlap .", "entities": [] }, { "id": "120", "type": "gene", "text": "Alanine substitution mutations in the Zta activation domain which eliminate the ability of Zta to stimulate the D - A complex were examined .", "entities": [ "Zta activation domain", "Zta", "D - A complex" ] }, { "id": "7759", "type": "gene", "text": "A cytosolic variant of the protein underwent efficient transphosphorylation , yet failed to activate appreciably either p70 ( S6k ) or MAP kinase following treatment with FK1012 .", "entities": [ "p70", "S6k", "MAP kinase" ] }, { "id": "3008", "type": "gene", "text": "Calibration and a correction of blood O2 content measured by Po2 and CO saturation .", "entities": [] }, { "id": "12059", "type": "gene", "text": "Analysis of the genome sequence revealed 26 , 588 protein - encoding transcripts for which there was strong corroborating evidence and an additional approximately 12 , 000 computationally derived genes with mouse matches or other weak supporting evidence .", "entities": [] }, { "id": "1128", "type": "gene", "text": "To gain an understanding of the mGSTM2 regulation , we have also cloned and analyzed its promoter region .", "entities": [ "mGSTM2" ] }, { "id": "6993", "type": "gene", "text": "The final screening yielded a clone containing a 2 kilobase ( kb ) insert .", "entities": [] }, { "id": "10677", "type": "gene", "text": "After a baseline study , WPW syndrome was simulated by stimulation at seven different sites around the base of the ventricles , and RNV ' s were obtained .", "entities": [] }, { "id": "11428", "type": "gene", "text": "Scintigraphic visualisation of Walker carcinoma - 256 in Sprague - Dawley rats by means of 99mTc - labelled monocytes .", "entities": [] }, { "id": "536", "type": "gene", "text": "Serum levels of IgG and IgM were also raised , but contrary to the findings of other observers IgA levels were normal .", "entities": [ "IgG", "IgM", "IgA" ] }, { "id": "6758", "type": "gene", "text": "On histologic examination the cuboidal epithelium of the mucous membrane was found to be changed into columnar epithelium , with uneven distribution of enlarged nuclei in the vacuolized cytoplasm .", "entities": [] }, { "id": "1518", "type": "gene", "text": "Therapy with dietary modification and triglyceride lowering drugs resulted in resolution of symptoms and parotid swelling in one patient .", "entities": [] }, { "id": "10116", "type": "gene", "text": "The proteins are more than 90 % identical to each other within the protein kinase domain but only 51 - 59 % identical to other casein kinase I isoforms within this region .", "entities": [ "casein kinase I isoforms" ] }, { "id": "8458", "type": "gene", "text": "ROS x SRC ( R ) contains a 16 - amino - acid deletion that includes the 3 ' half of the transmembrane domain of ros .", "entities": [ "ROS", "SRC", "R", "ros" ] }, { "id": "579", "type": "gene", "text": "Investigations using hippocampal slices maintained in vitro have demonstrated that bursts of oscillatory field potentials in the gamma frequency range ( 30 - 80 Hz ) are followed by a slower oscillation in the beta 1 range ( 12 - 20 Hz ) .", "entities": [] }, { "id": "3360", "type": "gene", "text": "Isolation and characterization of SRF accessory proteins .", "entities": [ "SRF accessory proteins" ] }, { "id": "6679", "type": "gene", "text": "Toluene is the chemical most frequently present in cases involving volatile solvents .", "entities": [] }, { "id": "11818", "type": "gene", "text": "The Oct and HMG2 proteins also interact in vivo .", "entities": [ "Oct", "HMG2 proteins" ] }, { "id": "5783", "type": "gene", "text": "Using an interspecific backcross panel , we localized both Gng3 and Gng3lg to the same locus on chromosome 19 .", "entities": [ "Gng3", "Gng3lg" ] }, { "id": "5206", "type": "gene", "text": "The cpc - 1 - encoded transcript contains three open reading frames , two of which are located in the 720 - nucleotide leader segment preceding the cpc - 1 coding region .", "entities": [ "cpc - 1 - encoded transcript", "cpc - 1 coding region" ] }, { "id": "9189", "type": "gene", "text": "Cotransfection of the helicase - primase proteins , one of which was fused to a heterologous activation domain , led to Zta - dependent superactivation of CAT expression .", "entities": [ "helicase", "primase", "Zta", "CAT" ] }, { "id": "2530", "type": "gene", "text": "Can thyroglobulin assay really supplant radioiodine scans in patients with differentiated thyroid cancer ?", "entities": [ "thyroglobulin" ] }, { "id": "2760", "type": "gene", "text": "CONCLUSION : These results suggest that vibration - induced neural involvement can be considered neither pure digital neuropathy , nor definite CTS , as previously described .", "entities": [] }, { "id": "5382", "type": "gene", "text": "The differences in the CPIgG , CRP , and fibrinogen levels in patients who were diagnosed with ACS versus those who were not ( non - ACS ) were evaluated .", "entities": [ "CPIgG", "CRP", "fibrinogen" ] }, { "id": "10165", "type": "gene", "text": "The psaD , psaF , psaH , and psaL products have two isoforms each that are distinguished by different mobilities in polyacrylamide gel electrophoresis , and the psaE product has four isoforms .", "entities": [ "psaD", "psaF", "psaH", "psaL products", "psaE product" ] }, { "id": "5676", "type": "gene", "text": "Correlating with the previous observation that CBF binding to the 78C1 site is enhanced by EGTA and EDTA , these divalent cation chelators specifically stimulate 78C1 - directed transcription .", "entities": [ "CBF" ] }, { "id": "443", "type": "gene", "text": "The mechanism by which large molecules , such as the diphosphonate 99mTc - labeled EHDP or 99mTc - labeled pyrophosphate , pass through capillaries in bone is by passive diffusion .", "entities": [] }, { "id": "4885", "type": "gene", "text": "Neurons were held at - 67 mV to equate voltage - dependent effects .", "entities": [] }, { "id": "7753", "type": "gene", "text": "Investigation on the exchange of Ca45 in intact and burned rats by the kinetic analysis method", "entities": [] }, { "id": "11099", "type": "gene", "text": "This activity is stimulated by complex formation with the other eIF2B subunits .", "entities": [ "eIF2B subunits" ] }, { "id": "1001", "type": "gene", "text": "Of these sites , PEA3 and STAT contributed specifically to induction by v - src , whereas the remaining elements were also involved in induction by the phorbol ester phorbol myristate acetate ( PMA ) .", "entities": [ "PEA3", "STAT", "v - src" ] }, { "id": "2788", "type": "gene", "text": "The across - fiber pattern of the responses to hypotonic NaCl solutions correlated strongly to that elicited by distilled H2O . ( ABSTRACT TRUNCATED AT 400 WORDS )", "entities": [] }, { "id": "7176", "type": "gene", "text": "To evaluate the effects of HRT on those factors in end - stage renal disease ( ESRD ) patients , we evaluated the changes of lipid profile , coagulation and fibrinolysis markers , and plasma homocysteine levels after treatment .", "entities": [] }, { "id": "3980", "type": "gene", "text": "Letter : Is actinic ( solar ) damage the provoking cause of ' post - inflammatory elastolysis and cutis laxa ( PECL ) ' ?", "entities": [] }, { "id": "4526", "type": "gene", "text": "However , parallax measurements showed that at 150K , collapse of Epon sections does not take place .", "entities": [] }, { "id": "4941", "type": "gene", "text": "RESULTS : The overall FNF for 1992 was 12 . 3 % and was 19 . 1 % , 22 . 2 % , 3 . 8 % and 6 . 1 % per successive quarters in 1992 .", "entities": [] }, { "id": "731", "type": "gene", "text": "Point mutations in the third SH3 domain abolished the vinexin - Sos interaction .", "entities": [ "SH3 domain", "vinexin", "Sos" ] }, { "id": "12182", "type": "gene", "text": "Upon analysis of the tissue distribution of AAMP , it was found to be expressed strongly in endothelial cells , cytotrophoblasts , and poorly differentiated colon adenocarcinoma cells found in lymphatics .", "entities": [ "AAMP" ] }, { "id": "1354", "type": "gene", "text": "Pol32Delta strains are weak antimutators and are defective for damage - induced mutagenesis .", "entities": [ "Pol32Delta" ] }, { "id": "7090", "type": "gene", "text": "A .", "entities": [] }, { "id": "11622", "type": "gene", "text": "We have synthesized [ 7 , 7 - 2H2 ] - 19 - OHA with high deuterium content and , together with [ 7 , 7 - 2H2 ] A and [ 9 , 11 - 2H2 ] estrone ( E1 ) , have developed a quantitative assay of serum level 19 - OHA , A , and E1 using the gas chromatography / mass spectrometry - mass fragmentography method to monitor individual subjects throughout pregnancy .", "entities": [] }, { "id": "4450", "type": "gene", "text": "Preparation of a stable phospholipid reagent for coagulation assays .", "entities": [] }, { "id": "11326", "type": "gene", "text": "Ischemic stroke due to protein C deficiency .", "entities": [ "protein C" ] }, { "id": "729", "type": "gene", "text": "Apoptosis of small cells is still observed after co - transfection of JBD and LMP1 but in addition a few apoptotic HD - MyZ cells with large fused nuclear masses are identified suggesting that specific inhibition of JNK leads also to apoptosis of LMP1 induced RS cells .", "entities": [ "JBD", "LMP1", "JNK", "LMP1" ] }, { "id": "9392", "type": "gene", "text": "Dopamine receptor blockade and the neuroleptics , a crystallographic study .", "entities": [ "Dopamine receptor" ] }, { "id": "9236", "type": "gene", "text": "Members of the JAK / Tyk family of tyrosine kinases mediate phosphorylation of STAT3 at Tyr705 during CNTF signaling ; however , the kinase responsible for phosphorylation at STAT3 Tyr727 appears to depend on both the extracellular stimulus and the cellular context .", "entities": [ "JAK", "Tyk", "tyrosine kinases", "STAT3", "CNTF", "STAT3" ] }, { "id": "11350", "type": "gene", "text": "The human U4 / U6 snRNP contains 60 and 90kD proteins that are structurally homologous to the yeast splicing factors Prp4p and Prp3p .", "entities": [ "U4", "U6", "Prp4p", "Prp3p" ] }, { "id": "2721", "type": "gene", "text": "Increases in the perfusate PCO2 but not in the perfusate H + were highly correlated with decreases in both myocardial contractility and oxygen consumption ( r2 = . 88 ) .", "entities": [] }, { "id": "3469", "type": "gene", "text": "Intracranial arachnoid cyst of the middle fossa demonstrated by positive 99mTc brainscintigraphy .", "entities": [] }, { "id": "5723", "type": "gene", "text": "Ectopic ACTH syndrome and medullary thyroid carcinoma .", "entities": [ "ACTH" ] }, { "id": "292", "type": "gene", "text": "Our evidence derives from three principal observations : 1 ) a transfection construct containing only 122 nucleotides ( nt ) of promoter 1 and 328 nt of the 5 ' - UTR retained full PGE2 - stimulated reporter expression ; 2 ) maximal PGE2 - driven reporter expression required the presence of nt 196 to 328 of exon 1 when tested within the context of IGF - I promoter 1 ; 3 ) cotransfection of IGF - I promoter - luciferase - reporter constructs with a plasmid encoding the alpha - isoform of the catalytic subunit of murine cAMP - dependent protein kinase ( PKA ) produced results comparable to those seen with PGE2 treatment , whereas cotransfection with a plasmid encoding a mutant regulatory subunit of PKA that cannot bind cAMP blocked PGE2 - induced reporter expression .", "entities": [ "IGF - I promoter 1", "IGF - I promoter", "luciferase", "murine cAMP - dependent protein kinase", "PKA", "PKA" ] }, { "id": "209", "type": "gene", "text": "CAL gain amounted to 4 . 2 + / - 1 . 3 mm , 60 % of the defects showing CAL gain > or = 4 mm .", "entities": [] }, { "id": "9346", "type": "gene", "text": "Anesthesia with M / K was reversed after 41 . 6 min of immobilization with atipamezole .", "entities": [] }, { "id": "2484", "type": "gene", "text": "Both the MVBF and the maximum EMG activity in the right masseter and the left anterior temporalis muscles were significantly decreased during muscle pain when the subjects bit on the painful side .", "entities": [] }, { "id": "3448", "type": "gene", "text": "Intravenous gamma globulins", "entities": [] }, { "id": "823", "type": "gene", "text": "Gene constructs possessing the complete tat , rev ( tat + rev + ) and env genes were transiently expressed in COS - 1 cells as precursor SU - TM ( gp160 ) , SU . TM ( gp120 x 41 ) , and nucleolar rev protein .", "entities": [ "complete tat", "rev", "rev +", "env genes", "precursor SU - TM", "gp160", "SU . TM", "gp120 x 41", "nucleolar rev protein" ] }, { "id": "10090", "type": "gene", "text": "We have shown previously that GH3 cells transfected with the rat GnRH receptor cDNA ( GGH3 - 1 ' cells ) support the expression of a cotransfected fusion gene composed of 797 base pairs of rat LHbeta gene 5 ' - flanking sequence and the first 5 base pairs of the 5 ' - untranslated region fused to a luciferase reporter ( - 797 / + 5LHbetaLUC ) and respond to a GnRH agonist with a 10 - fold stimulation of activity .", "entities": [ "rat GnRH receptor cDNA", "rat LHbeta gene 5 ' - flanking sequence", "luciferase reporter ( - 797 / + 5LHbetaLUC )", "GnRH" ] }, { "id": "140", "type": "gene", "text": "Here we describe and map two more new genes identified as allele - specific suppressors that compensate for carboxy - terminal truncation of PET122 .", "entities": [ "PET122" ] }, { "id": "8186", "type": "gene", "text": "We have identified amino acid sequences in mammalian and Xenopus NeuroD1 / BETA2 that are necessary for insulin gene expression and ectopic neurogenesis .", "entities": [ "NeuroD1", "BETA2", "insulin gene" ] }, { "id": "3539", "type": "gene", "text": "33 out of 90 neurons of the cat medial geniculate body revealed the selectivity of their afterdischarges to movement of sound when velocity of the movement changed from 30 to 180 deg / s .", "entities": [] }, { "id": "10743", "type": "gene", "text": "The promoter activity of the proximal region was found to be restricted to a subset of prestalk cells .", "entities": [] }, { "id": "9389", "type": "gene", "text": "Sustained ventricular tachycardia and its successful prophylaxis during high - dose bolus interleukin - 2 therapy for metastatic renal cell carcinoma .", "entities": [ "interleukin - 2" ] }, { "id": "5403", "type": "gene", "text": "These observations of elevated serum lipase and serum CA 19 - 9 in Sjogren ' s syndrome without evidence of malignancy may reflect pancreatic involvement in this disorder .", "entities": [ "serum lipase", "CA 19 - 9" ] }, { "id": "4541", "type": "gene", "text": "The results obtained were as follows : The mitral valve orifice area ( MVA ) was significantly smaller in patients with type III of the LVIT flow velocity pattern than in patients with type I ( p less than 0 . 001 ) .", "entities": [] }, { "id": "4765", "type": "gene", "text": "When the downstream operator was altered , there was a fourfold reduction in reporter enzyme levels .", "entities": [] }, { "id": "9034", "type": "gene", "text": "Currently , the clinical use of 5 - aminolaevulinic acid ( ALA ) induced protoporphyrin IX ( PPIX ) for photodynamic therapy ( PDT ) is limited by the maximum tolerated oral ALA dose ( 60 mg / kg ) .", "entities": [ "protoporphyrin IX", "PPIX" ] }, { "id": "8291", "type": "gene", "text": "Overexpression of H411 cDNA in the RAW 264 . 7 macrophage cell line promoted an increased growth rate , suggesting that expression of H411 is part of the proliferative cell response to LPS .", "entities": [ "H411 cDNA", "H411" ] }, { "id": "8700", "type": "gene", "text": "Thus , both YY1 and CDP appear to be negative regulators of the differentiation - induced HPV - 6 E1 promoter and thereby the HPV life cycle .", "entities": [ "YY1", "CDP", "HPV - 6 E1 promoter" ] }, { "id": "4069", "type": "gene", "text": "We also mapped a 3 ' - polyadenylation site 504bp downstream of the TGA stop codon , consistent with the 2 . 5kb transcript size .", "entities": [] }, { "id": "427", "type": "gene", "text": "We present a case of type II hyperbetalipoproteinemia in a patient whose diagnosis had been previously unrecognized , and who had previously been misdiagnosed with rheumatoid arthritis and later gout .", "entities": [] }, { "id": "12535", "type": "gene", "text": "Two of these resulted in increased levels of the alpha subunit , and one caused a substitution of glycine for the aspartic acid residue at position 171 , in the N - terminal domain .", "entities": [] }, { "id": "5288", "type": "gene", "text": "The results presented in this report suggest that the SV40 G - C - rich sequences can function as independent RNA polymerase II transcriptional - control elements .", "entities": [ "RNA polymerase II" ] }, { "id": "1624", "type": "gene", "text": "FK 33 - 824 , a methionine - enkephalin analogue , suppressed plasma ACTH to 85 % of basal level , while bromocriptine ( CB - 154 ) caused no significant change .", "entities": [ "enkephalin", "ACTH" ] }, { "id": "8500", "type": "gene", "text": "Surprisingly , the CSF1R / IRDelta960 was as effective as the CSF1R / IR in mediating CSF - 1 protection of cells from staurosporine - induced apoptosis .", "entities": [ "CSF1R", "IRDelta960", "CSF1R", "IR", "CSF - 1" ] }, { "id": "3399", "type": "gene", "text": "However , in TF - 1 cells grown on GM - CSF before starvation , CREB phosphorylation was observed 10 minutes after PIXY321 stimulation .", "entities": [ "GM - CSF", "CREB", "PIXY321" ] }, { "id": "6260", "type": "gene", "text": "The present study investigated dose dependence and time course effects of the benzodiazepine ( BDZ ) partial inverse agonist , RO19 - 4603 ( 0 . 005 - 0 . 30 mg / kg ) alone , and in combination with the BDZ receptor antagonists flumazenil , ZK 93426 , and CGS 8216 ( 20 mg / kg ) in selectively bred alcohol - preferring ( P ) rats provided a two - bottle choice test between ethanol ( EtOH ) ( 10 % v / v ) , and a palatable saccharin ( 0 . 0125 % g / v ) solution .", "entities": [ "BDZ receptor" ] }, { "id": "6499", "type": "gene", "text": "CONCLUSIONS : While INR correction may be achieved by all the above methods , that relating log reference INR to log local prothrombin time by linear regression analysis is the simplest to perform .", "entities": [ "prothrombin" ] }, { "id": "3400", "type": "gene", "text": "When combined with serum ferritin and hemoglobin determinations , the serum transferrin receptor assay is a valuable addition in epidemiologic surveys because it provides a quantitative measure of functional iron deficiency and it distinguishes true IDA from the anemia of chronic disease .", "entities": [ "ferritin", "hemoglobin", "transferrin receptor" ] }, { "id": "8406", "type": "gene", "text": "Moreover , moderate overexpression of Chk1 suppresses the phenotypes of cut5 and crb2 mutants .", "entities": [ "Chk1", "cut5", "crb2 mutants" ] }, { "id": "7579", "type": "gene", "text": "In transient assays , using rice suspension - cultured cells transformed by particle bombardment , we showed previously that Oshox1 can transcriptionally repress the activity of reporter gene constructs with upstream HD - Zip binding sites .", "entities": [ "Oshox1", "HD - Zip" ] }, { "id": "2981", "type": "gene", "text": "A cdc33 - 1 strain expressing either stable Cln3p ( Cln3 - 1p ) or a hybrid UBI4 5 ' - CLN3 mRNA , whose translation displays decreased dependence on eIF4E , arrested randomly in the cell cycle .", "entities": [ "cdc33 - 1", "Cln3p", "Cln3 - 1p", "UBI4 5 ' - CLN3", "eIF4E" ] }, { "id": "8322", "type": "gene", "text": "Only two patients ( 0 . 3 % ) had a CA 125 response at the time of clinical progression .", "entities": [ "CA 125" ] }, { "id": "11455", "type": "gene", "text": "These regions overlap with the HIT protein similarity regions .", "entities": [ "HIT protein similarity regions" ] }, { "id": "1237", "type": "gene", "text": "We further demonstrate that RU486 - PR - B interacts physically with NCoR in vitro .", "entities": [ "PR - B", "NCoR" ] }, { "id": "6305", "type": "gene", "text": "To minimize reflux into the blind loop , a number of technical steps are considered indispensable : 1 ) fluted section of the jejunal stump ; 2 ) isoperistaltic construction of the anastomosis and , particularly , 3 ) the creation of a single or double valve system upstream from the anastomosis by spiral introflexion of the mucosa using seroserous stitches parallel and perpendicular to the ileal lumen .", "entities": [] }, { "id": "6858", "type": "gene", "text": "Epitope mapping revealed that these three clones appear to recognize an identical epitope domain present on the C - terminal RNP motif of the U1A protein .", "entities": [ "U1A protein" ] }, { "id": "4125", "type": "gene", "text": "In this study , the abilities of constitutive and conditional forms of the three Raf kinases to abrogate the cytokine dependency of FDC - P1 cells were examined .", "entities": [ "Raf kinases" ] }, { "id": "4594", "type": "gene", "text": "First , a pet54 : : LEU2 cytoductant bearing the ' short ' mitochondrial genome that lacks both COX1 introns aI5 alpha and aI5 beta is defective only in COX3 gene expression and not in COX1 mRNA splicing or mRNA translation .", "entities": [ "pet54", "LEU2", "aI5 alpha", "aI5 beta", "COX3 gene", "COX1 mRNA" ] }, { "id": "1182", "type": "gene", "text": "The applicability of laparoscopic donor nephrectomy ( LDN ) has not been assessed in the obese donor .", "entities": [] }, { "id": "4341", "type": "gene", "text": "Commutative saccadic generator is sufficient to control a 3 - D ocular plant with pulleys .", "entities": [] }, { "id": "6947", "type": "gene", "text": "Corneal scrapping and deep stromal biopsy were obtained and stained for microscopic evaluation with periodic acid - Schiff , Giemsa , and Gomori ' s methenamine silver stains .", "entities": [] }, { "id": "3143", "type": "gene", "text": "Allergenic activity of allergen extract Ambrosia elatior ( AE ) was tested in fifteen volunteers extremely sensitive to the allergen .", "entities": [] }, { "id": "11232", "type": "gene", "text": "Analyses of additional tumors induced in mice from two reciprocal crosses , A / J x C3H / HeJ F1 ( hereafter called AC3F1 ) and C3H / HeJ x A / J F1 ( hereafter called C3AF1 ) , provided evidence for the inactivation of one allele of the putative chromosome 4 tumor suppressor gene by parental imprinting .", "entities": [] }, { "id": "3370", "type": "gene", "text": "The in vitro antibacterial potency is greatest when the 1 - substituent is 2 , 4 - difluorophenyl and the 7 - substituent is a 3 - amino - 1 - pyrrolidinyl group .", "entities": [] }, { "id": "665", "type": "gene", "text": "The mechanism underlying such analgesia has been suggested to involve the interaction between the two separate but interconnected motivational systems \" defense \" and \" pain . \" To determine the developmental course of defense and nociception , these processes were analyzed during early ontogeny in rats .", "entities": [] }, { "id": "2307", "type": "gene", "text": "All 89 participating household members were anti - HIV seronegative , and 78 who were tested were serum p24 antigen negative .", "entities": [ "anti - HIV", "serum p24 antigen" ] }, { "id": "4796", "type": "gene", "text": "This 300 bp 5 ' - upstream sequence of K3 keratin gene , which can function in vitro as a keratinocyte - specific promoter , contains two clusters of partially overlapping motifs , one with an NFkB consensus sequence and another with a GC box .", "entities": [ "K3 keratin gene", "NFkB" ] }, { "id": "1934", "type": "gene", "text": "Serine 528 is phosphorylated in vivo in several cell lines , and substitution of serine 528 to alanine ( S528A ) resulted in an increased ability of Myb to transactivate a synthetic promoter containing five copies of the mim - 1A Myb - responsive element and a minimal herpes tk promoter .", "entities": [ "Myb", "Myb", "herpes tk promoter" ] }, { "id": "7134", "type": "gene", "text": "Myocardial SPET imaging with 99Tcm - tetrofosmin in clinical practice : comparison of a 1 day and a 2 day imaging protocol .", "entities": [] }, { "id": "5525", "type": "gene", "text": "IL - 1 and TNF increase AND - 34 transcript levels in thymic cortical reticular , thymic nurse , and fibroblast cell lines .", "entities": [ "IL - 1", "TNF", "AND - 34 transcript" ] }, { "id": "12164", "type": "gene", "text": "To confirm the binding of protein to these sites in cells , we carried out an in vivo genomic footprinting analysis of this portion of the TGF alpha promoter in normal and transformed rat liver epithelial cell lines that express the endogenous gene at varying levels .", "entities": [ "TGF alpha promoter" ] }, { "id": "11761", "type": "gene", "text": "There was a 2 . 4 - fold difference in CAT produced from these transcripts in HeLa cells , which contain a greater natural abundance of PTB .", "entities": [ "CAT", "PTB" ] }, { "id": "6340", "type": "gene", "text": "The Lm increased and the alveoli / mm2 and elastic recoil pressure decreased .", "entities": [] }, { "id": "5909", "type": "gene", "text": "This report presents state - specific MMRs for 1987 - 1996 , focusing on persistent disparities in maternal mortality between black and white women .", "entities": [] }, { "id": "4794", "type": "gene", "text": "After two successive rounds of selection by focus formation assay , a transforming ribozyme ( Rz007 ) was identified .", "entities": [ "Rz007" ] }, { "id": "8425", "type": "gene", "text": "TCZ provides quick , inexpensive , noninvasive indication of tissue necrosis , moderate - to - severe intracranial hemorrhage , and delayed brain maturation .", "entities": [] }, { "id": "2101", "type": "gene", "text": "Leads from the MMWR .", "entities": [] }, { "id": "485", "type": "gene", "text": "These findings indicate that autophosphorylation of Thr286 ( alpha subunit ) and Thr287 ( beta subunit ) is responsible for transition of CaM - kinase II to the Ca2 + - independent form .", "entities": [ "CaM - kinase II" ] }, { "id": "8359", "type": "gene", "text": "A cDNA cloning vector that permits expression of cDNA inserts in mammalian cells .", "entities": [] }, { "id": "4060", "type": "gene", "text": "CYP2C19 genotype was determined by the polymerase chain reaction - restriction fragment length polymorphism method .", "entities": [ "CYP2C19 genotype" ] }, { "id": "420", "type": "gene", "text": "Pneumonia in children", "entities": [] }, { "id": "3494", "type": "gene", "text": "Using the polymerase chain reaction , we analyzed the U6 RNA genes of 52 organisms .", "entities": [ "U6 RNA genes" ] }, { "id": "594", "type": "gene", "text": "Only 17 % of all patients admitted it at all times .", "entities": [] }, { "id": "1361", "type": "gene", "text": "The results presented here show that AR1 of the promoter - proximal CAP subunit was required for papBA transcription even in the absence of the histone - like protein H - NS .", "entities": [ "AR1", "CAP subunit", "papBA", "H - NS" ] }, { "id": "1879", "type": "gene", "text": "Biol .", "entities": [] }, { "id": "5357", "type": "gene", "text": "After 2 min of dobutamine injection , or after 20 min of pimobendan injection , the myocardium was removed , and used for determination of the tissue levels of metabolites of energy and carbohydrate metabolism .", "entities": [] }, { "id": "7272", "type": "gene", "text": "The levels of transactivation are correlated with the respective binding affinities of the response elements ( IRper - 1 > DR - 4 > IRhsp - 1 ) .", "entities": [] }, { "id": "6064", "type": "gene", "text": "These mutations , when placed in a wild - type fliF background , had no mutant phenotype .", "entities": [ "wild - type fliF" ] }, { "id": "8577", "type": "gene", "text": "Vitamin D3 and calcium absorption in the chick .", "entities": [] }, { "id": "5189", "type": "gene", "text": "Contingency contracting between clients and their parents / caregivers was used to specify consequences for daily self - monitoring , reduced caloric intake , weight loss , and exercise .", "entities": [] }, { "id": "3491", "type": "gene", "text": "Sequence analysis revealed that in addition to the non - spliced variant , multiple mRNA species were generated by alternative splicing resulting in the exclusion of 92 , 166 , 170 , 174 and 263 nucleotides ( nt ) , respectively , from exon 1 .", "entities": [] }, { "id": "5998", "type": "gene", "text": "However , the increase in biliary excretion did not compensate for the reduced elimination of bretylium and hexylsalicylic acid via the kidney .", "entities": [] }, { "id": "9486", "type": "gene", "text": "Since considerable variations in length and primary sequence in the CDR3 ( complementarity determining region ) peptides of all the H - chains are evident , conservation of the D - region structure does not appear to be necessary for effective hapten binding .", "entities": [ "CDR3", "complementarity determining region", "H - chains", "D - region" ] }, { "id": "6160", "type": "gene", "text": "Assay of serum immunoreactive trypsin in dried blood spots and the early detection of cystic fibrosis .", "entities": [ "serum immunoreactive trypsin" ] }, { "id": "8562", "type": "gene", "text": "Biopsies of the jejunal mucosa have shown abnormal enzyme activity or deficiencies in transport mechanisms .", "entities": [] }, { "id": "7101", "type": "gene", "text": "A new echocardiographic technique is described with a conventional M mode , digitalised 2D and tissular Doppler which has a comparable ability to identify the anomalous pathways of electric conduction using a non - invasive method .", "entities": [] }, { "id": "617", "type": "gene", "text": "However , at 18 months of age , significantly higher levels of IgG1 ( P less than 0 . 05 ) and of IgG4 ( P less than 0 . 01 ) were found in infants with an elevated IgE ( greater than or equal to 8 . 0 kU / l ) than in those with a lower level .", "entities": [ "IgG1", "IgG4", "IgE" ] }, { "id": "2291", "type": "gene", "text": "By order of decreasing rate , finger flexors , jaw , crossed adductors , and triceps reflexes were less frequently elicited in both groups .", "entities": [] }, { "id": "11853", "type": "gene", "text": "The recombinant vaccinia virus - expressed mutant P1 polyproteins were analyzed for proteolytic processing defects in cells coinfected with a recombinant vaccinia virus ( VVP3 ) that expresses the poliovirus 3CD protease and for processing and assembly defects by using a trans complementation system in which P1 - expressing recombinant vaccinia viruses provide capsid precursor to a defective poliovirus genome that does not express functional capsid proteins ( D .", "entities": [ "recombinant vaccinia virus - expressed mutant P1 polyproteins", "poliovirus 3CD protease", "P1", "capsid precursor", "capsid proteins" ] }, { "id": "4745", "type": "gene", "text": "The persistent fetal dispersion of nodal and Hiss bundle fragments within the ventricular septum is proposed as a possible explanation .", "entities": [] }, { "id": "3194", "type": "gene", "text": "Transcervical amnioinfusion .", "entities": [] }, { "id": "5471", "type": "gene", "text": "An ion chromatographic method was used to determine Br ion in the urine of Greyhounds .", "entities": [] }, { "id": "7572", "type": "gene", "text": "It is exclusively observed in smooth muscle cells by Northern blotting and immunohistochemical analysis and therefore designated \" smoothelin . \" A human smooth muscle cDNA library was screened with the monoclonal antibody R4A , and a full - size cDNA of the protein was selected .", "entities": [ "\" smoothelin . \"", "monoclonal antibody R4A" ] }, { "id": "4994", "type": "gene", "text": "These studies demonstrate that both G alpha i genes are dynamically regulated in LLC - PK1 cells by both growth , differentiation , and hormone signals .", "entities": [ "G alpha i genes" ] }, { "id": "12271", "type": "gene", "text": "The mutant protein is present at levels slightly greater than wild - type , but exhibits the same tissue distribution as wild - type protein , and has approximately normal affinity for known target sequences ( though no DNA targets identified to date require the first cut repeat for binding ) .", "entities": [] }, { "id": "1660", "type": "gene", "text": "Ten - year experience with one - stage proctocolectomy and anal ileostomy .", "entities": [] }, { "id": "11460", "type": "gene", "text": "Triumph of Leninist national policy", "entities": [] }, { "id": "997", "type": "gene", "text": "Ariga , Biochem .", "entities": [] }, { "id": "3203", "type": "gene", "text": "Aspirin causes peptic ulcers predominately by reducing gastric mucosal cyclooxygenase ( COX ) activity and prostaglandin synthesis .", "entities": [ "gastric mucosal cyclooxygenase", "COX" ] }, { "id": "4766", "type": "gene", "text": "Our results , when combined with previously published in vitro results , support a direct role for Prp44p in unwinding of the U4 / U6 helix .", "entities": [ "Prp44p", "U4", "U6" ] }, { "id": "3237", "type": "gene", "text": "The initial inpatient experience for individuals with HIV - related TB may be pivotal to the acceptance of and participation in ongoing TB care .", "entities": [] }, { "id": "10189", "type": "gene", "text": "Hydrocoele is common in men in Wuchereria bancrofti - endemic areas , the treatment for which is currently surgical intervention .", "entities": [] }, { "id": "4627", "type": "gene", "text": "The status of education and training programs in speech pathology and audiology - - 1971 - 72 .", "entities": [] }, { "id": "1302", "type": "gene", "text": "About 20 % of single - stranded DNA binding was observed in the presence of MgdTDP , but none was detectable in the absence of nucleotides .", "entities": [] }, { "id": "5349", "type": "gene", "text": "The results indicate that the carbon - perfused areas and MBF in the liver , renal cortex , spleen , and small intestinal serosa ( only MBF ) increased significantly 5 h after CLP .", "entities": [] }, { "id": "1000", "type": "gene", "text": "Ten weeks after reconstruction , the regenerating nerves already resembled normal nerves .", "entities": [] }, { "id": "10565", "type": "gene", "text": "Rat kidney carboxylesterase .", "entities": [ "Rat kidney carboxylesterase" ] }, { "id": "11439", "type": "gene", "text": "Using lectin - affinity chromatography , discordance between the pattern of O - glycosylation of SSBP and DSBP was demonstrated .", "entities": [ "lectin", "SSBP", "DSBP" ] }, { "id": "8263", "type": "gene", "text": "The effect of these cell cycle regulators is not specific to the rap1s or hmr delta A mutation , since swi6 , swi4 , and clb5 mutations also suppress mutations in SIR1 , another gene implicated in the establishment of silencing .", "entities": [ "rap1s", "hmr delta A mutation", "swi6", "swi4", "clb5 mutations", "SIR1" ] }, { "id": "8140", "type": "gene", "text": "The most likely explanation for this is that gold principally accumulates in the Kupffer cells and renal cortex and these cells do not express Type I deiodinase .", "entities": [ "Type I deiodinase" ] }, { "id": "10988", "type": "gene", "text": "Hyaluronan treatment stimulated collagen remodeling in the peripheral region and inhibited swelling of the meniscus repaired in the inner region .", "entities": [ "collagen" ] }, { "id": "2337", "type": "gene", "text": "Hb levels remained adequate ( Hb = 10 . 68 + / - 0 . 77 g / dl ) after 14 . 6 + / - 7 . 64 months .", "entities": [ "Hb", "Hb" ] }, { "id": "8836", "type": "gene", "text": "Cross - linking the B cell Ag receptor ( BCR ) to surface Fc receptors for IgG ( Fc gamma R ) inhibits G1 - to - S progression ; the mechanism by which this occurs is not completely known .", "entities": [ "B cell Ag receptor", "BCR", "surface Fc receptors", "IgG", "Fc gamma R" ] }, { "id": "644", "type": "gene", "text": "ATP by itself also reduced polypeptide binding to Ssb1 / 2p to a level that was intermediate between that observed for the Ssa Hsp70 proteins tested and BiP and DnaK .", "entities": [ "Ssb1 / 2p", "Hsp70 proteins", "BiP", "DnaK" ] }, { "id": "8103", "type": "gene", "text": "The 26S rRNA binding ribosomal protein equivalent to bacterial protein L11 is encoded by unspliced duplicated genes in Saccharomyces cerevisiae .", "entities": [ "26S rRNA binding ribosomal protein", "bacterial protein L11" ] }, { "id": "11031", "type": "gene", "text": "Cestode invasion in irradiated host organism increases the negative effect of ionizing radiation on the hamster immune system .", "entities": [] }, { "id": "344", "type": "gene", "text": "This partial transection could permit vasopressin to be secreted in response to a larger rise in plasma sodium concentration .", "entities": [ "vasopressin" ] }, { "id": "1706", "type": "gene", "text": "CONCLUSIONS : These findings indicate a physical barrier of oesophageal surfactant which could offer some degree of protection against gastro - oesophageal reflux but one which is particularly prone to attack by bile .", "entities": [] }, { "id": "9180", "type": "gene", "text": "A 7 - day treatment of amphotericin B ( 5 mg / kg / day i . p . ) significantly reduced the glomerular filtration rate ( GFR ) measured as inuline clearance and creatinine clearance ( 0 . 74 + / - 0 . 29 and 0 . 16 + / - 0 . 04 ml / min , respectively ) in comparison to vehicle - treated rats ( 2 . 04 + / - 0 . 23 and 1 . 29 + / - 0 . 19 ml / min , respectively ) .", "entities": [] }, { "id": "9372", "type": "gene", "text": "The ' Newcastle ' model , which is based on Hotelling ' s T2 statistic , proved to be more sensitive and diagnosed a systematic displacement for three prostate patients .", "entities": [] }, { "id": "9443", "type": "gene", "text": "Potscoital test", "entities": [] }, { "id": "6612", "type": "gene", "text": "POU - specific and POU - homeo domains of Oct3 were produced in Echerichia coli for characterization of DNA binding to the octamer sequence .", "entities": [ "POU", "POU", "Oct3" ] }, { "id": "12021", "type": "gene", "text": "Both genes comprise three exons , two introns and an unusually long 3 ' - untranslated region ( 3 . 2 kilobase pairs ) , specificying a mRNA of approximately 4 . 1 kilobases .", "entities": [] }, { "id": "3691", "type": "gene", "text": "OBJECTIVE : To follow - up prospectively patients with arthritis after infection with beta - haemolytic streptococci of Lancefield group A ( beta HSA ) , with emphasis on clinical characteristics and serological features .", "entities": [] }, { "id": "12270", "type": "gene", "text": "In addition , we did not detect significant differences in CDR3 sequences of endogenous Ig lambdaL and kappaL chain gene loci cloned from peripheral blood lymphocytes of an NBS patient and of healthy individuals .", "entities": [ "CDR3 sequences", "endogenous Ig lambdaL", "kappaL chain gene loci" ] }, { "id": "12155", "type": "gene", "text": "The kappa coefficient of agreement between the Patho Dx Kit and the standard method was 0 . 958 .", "entities": [] }, { "id": "6434", "type": "gene", "text": "Methisergide ( 0 . 5 mg / kg , i . p . ) , a blocker of serotonin receptors , prevented the development of the antinociceptive effect of serotonin .", "entities": [ "serotonin receptors" ] }, { "id": "5900", "type": "gene", "text": "Survival of 111 Indium - labelled autologous platelets was studied in 2 patients after correction of platelet count and was still found shortened .", "entities": [] }, { "id": "4805", "type": "gene", "text": "In the studies reported here , the 5 ' - flanking region of the human gp130 gene was isolated and the transcription initiation sites were mapped .", "entities": [ "human gp130 gene" ] }, { "id": "5410", "type": "gene", "text": "Through two novel mechanisms , Arf inhibits the oncoprotein Hdm2 , a negative regulator of p53 .", "entities": [ "Arf", "oncoprotein Hdm2", "p53" ] }, { "id": "3176", "type": "gene", "text": "By Caveman .", "entities": [] }, { "id": "10423", "type": "gene", "text": "Of the 21 quadrants positive in the controls , 17 were correlated with previously detected jaw pathoses .", "entities": [] }, { "id": "9306", "type": "gene", "text": "These results confirmed that cleavage of the leader peptide is the last step in nisin maturation and is necessary to generate a biologically active peptide .", "entities": [ "nisin" ] }, { "id": "4596", "type": "gene", "text": "A novel phosphotyrosine - binding domain in the N - terminal transforming region of Cbl interacts directly and selectively with ZAP - 70 in T cells .", "entities": [ "Cbl", "ZAP - 70" ] }, { "id": "7739", "type": "gene", "text": "Interestingly , this amino - terminal determinant appears not to reside in the HSV - alpha TIF , which displays no independent amino - terminal activity .", "entities": [ "alpha TIF" ] }, { "id": "912", "type": "gene", "text": "Of 115 hepatitis B patients seen at 12 months , 6 % had chronic hepatitis Bs antigenaemia , 60 % had developed anti - HBs antibodies , and 7 . 3 % still had abnormal liver function .", "entities": [ "anti - HBs antibodies" ] }, { "id": "4838", "type": "gene", "text": "Amino acid sequence comparisons of the E74A protein reveal a highly conserved C - terminal region that is rich in basic amino acid residues and which has been proposed to possess sequence - specific DNA binding activity .", "entities": [ "E74A protein" ] }, { "id": "11033", "type": "gene", "text": "Here , we show that aortic explants isolated from PPARalpha - null mice display an exacerbated response to inflammatory stimuli , such as lipopolysaccharide ( LPS ) , as demonstrated by increased IL - 6 secretion .", "entities": [ "PPARalpha", "IL - 6" ] }, { "id": "2280", "type": "gene", "text": "A genetic screen in yeast has allowed us to identify a novel transcriptional factor binding to the GlRE , i . e . the chicken ovalbumin upstream promoter - transcription factor II ( COUP - TFII ) .", "entities": [ "chicken ovalbumin upstream promoter - transcription factor II", "COUP - TFII" ] }, { "id": "217", "type": "gene", "text": "The third ORF generates a transcript of 1 . 6 kb and encodes a protein of 382 residues including a perfect match to the consensus sequence of a C2H2 zinc finger domain ; it shares a strong homology with yeast Mig1p and Cre - A from Aspergillus , Emericella and E . coli .", "entities": [ "yeast Mig1p", "Cre - A from Aspergillus , Emericella and E . coli" ] }, { "id": "596", "type": "gene", "text": "Based on the comparison of the predicted amino acid sequences of 1 - sst and 1 - fft with those of other plant fructosyl transferase genes , we postulate that both plant fructan genes have evolved from plant invertase genes .", "entities": [ "1 - sst", "1 - fft", "fructosyl transferase genes", "fructan genes", "invertase" ] }, { "id": "3268", "type": "gene", "text": "This plus the reduced phosphorylation of p27 by MAPK enhanced the stability of p27 that associated with nuclear Cdk2 at high stoichiometry and inhibited its kinase activity .", "entities": [ "p27", "MAPK", "p27", "nuclear Cdk2" ] }, { "id": "5496", "type": "gene", "text": "Cross - linking FcalphaR on wt - ITAM or IIA - ITAM cells triggered equivalent PI 3 - kinase - dependent activation of PKBalpha .", "entities": [ "FcalphaR", "wt - ITAM", "IIA - ITAM", "PI 3 - kinase", "PKBalpha" ] }, { "id": "3304", "type": "gene", "text": "Wild - type protein bound azido - ATP well , but mutants with substitutions in the consensus amino acids were unable to bind azido - ATP .", "entities": [] }, { "id": "3997", "type": "gene", "text": "Obesity was strongly associated with the proportions of nonprotein - bound and albumin - bound estradiol , and inversely associated with sex hormone binding globulin ( SHBG ) levels and the proportion of SHBG - bound estradiol .", "entities": [ "albumin", "sex hormone binding globulin", "SHBG", "SHBG" ] }, { "id": "10603", "type": "gene", "text": "2 .", "entities": [] }, { "id": "7668", "type": "gene", "text": "The transcription factor CHOP ( C / EBP homologous protein 10 ) is a bZIP protein induced by a variety of stimuli that evoke cellular stress responses and has been shown to arrest cell growth and to promote programmed cell death .", "entities": [ "transcription factor CHOP", "C / EBP homologous protein 10", "bZIP protein" ] }, { "id": "2418", "type": "gene", "text": "The functions of isolated portions of the insulin , IAPP , and beta GK promoters were studied by using transient expression and DNA binding assays .", "entities": [ "insulin", "IAPP", "beta GK promoters" ] }, { "id": "10177", "type": "gene", "text": "The Novacor Left Ventricular Assist System ( LVAS ) ( Novacor Corp , Oakland , CA ) was initially console - based and has been available since 1993 in a wearable configuration .", "entities": [] }, { "id": "5230", "type": "gene", "text": "DNA polymerase E , DNA ligase III and a DNA structure - specific endonuclease co - purify with the five polypeptide complex .", "entities": [ "DNA polymerase E", "DNA ligase III" ] }, { "id": "12103", "type": "gene", "text": "An unusual feature of these replicative genes is that the smaller mRNA begins within a long open reading frame of the larger mRNA .", "entities": [] }, { "id": "10426", "type": "gene", "text": "Calcitriol therapy was associated with a decrease in serum iPTH levels ( 701 + / - 103 . 9 vs .", "entities": [ "iPTH" ] }, { "id": "5858", "type": "gene", "text": "Supplementary Phase Contraste RSE ( \" Rapid Sequential Excitation \" ) sequences were carried out in 29 patients .", "entities": [] }, { "id": "10746", "type": "gene", "text": "The problem of disablement due to pulmonary tuberculosis , on the basis of an analysis of the history of 395 cases as observed in Gdansk in the years 1946 - 1965", "entities": [] }, { "id": "6834", "type": "gene", "text": "Temperature - shift experiments using synchronously grown cells of a delta top1 top2 temperature - sensitive ( ts ) double mutant and its isogenic top2 ts strain show that , whereas mitotic blocks can prevent killing of the top2 ts mutant at a nonpermissive temperature , the same treatments are ineffective in preventing cell death of the delta top1 top2 ts double mutant .", "entities": [ "top2 temperature - sensitive ( ts ) double mutant", "top2", "top2 ts mutant", "top2 ts double mutant" ] }, { "id": "1762", "type": "gene", "text": "Role of the transcription start site core region and transcription factor YY1 in Rous sarcoma virus long terminal repeat promoter activity .", "entities": [ "transcription factor YY1", "Rous sarcoma virus long terminal repeat promoter" ] }, { "id": "3021", "type": "gene", "text": "These results indicate that both naturally acquired and passive ( modified immune serum globulin ) antibodies to type III group B Streptococcus antigen are partially protective against intra - amniotic infection .", "entities": [ "immune serum globulin", "type III group B Streptococcus antigen" ] }, { "id": "10293", "type": "gene", "text": "Nine cats received PMEA at a dosage of 10 mg / kg body weight , nine cats received FPMPA at a dosage of 25 mg / kg body weight .", "entities": [] }, { "id": "3066", "type": "gene", "text": "Postglucose serum insulin levels showed no significant correlations with systolic or diastolic blood pressure levels in men , but in female diabetic and non - diabetic subjects significant correlations were found in particular with systolic blood pressure level .", "entities": [ "serum insulin" ] }, { "id": "199", "type": "gene", "text": "Human acid ceramidase ( ( AC ) N - acylsphingosine amidohydrolase , EC 3 . 5 .", "entities": [ "Human acid ceramidase", "( AC ) N - acylsphingosine amidohydrolase", "EC 3 . 5" ] }, { "id": "11421", "type": "gene", "text": "In addition , an mck1 mds1 mrk1 triple disruptant was viable .", "entities": [ "mrk1" ] }, { "id": "6339", "type": "gene", "text": "Mild orbital discomfort occurred in some patients .", "entities": [] }, { "id": "8", "type": "gene", "text": "Hematology problem of the month : band or seg ?", "entities": [] }, { "id": "1359", "type": "gene", "text": "Ventral rhinotomy is no more difficult than dorsal rhinotomy , has less patient morbidity and fewer postoperative complications , and is more cosmetically acceptable .", "entities": [] }, { "id": "10357", "type": "gene", "text": "Diuretics : basic clinical pharmacology and therapeutic use .", "entities": [] }, { "id": "7351", "type": "gene", "text": "Value of the EMG in the diagnosis of a cardiomyopathy associated with a myotonic myopathy .", "entities": [] }, { "id": "4507", "type": "gene", "text": "Vascular responses to reactive hyperemia ( with flow increase leading to endothelium - dependent dilation ) and to sublingual glyceryl trinitrate ( GTN ; endothelium - independent dilation ) were recorded .", "entities": [] }, { "id": "5335", "type": "gene", "text": "Relative to coherent control words ( e . g . , quick ) , these discourse - dependent semantic anomalies elicited a large N400 effect that began at about 200 to 250 msec after word onset .", "entities": [] }, { "id": "7340", "type": "gene", "text": "These data provide evidence that the 2 . 0 - kb LAT is an intron of the mLAT pre - mRNA with a unique branch point .", "entities": [ "2 . 0 - kb LAT", "mLAT pre - mRNA" ] }, { "id": "11804", "type": "gene", "text": "In this study we examined hepatic stellate cell regulation of M6P / IGFIIR expression and found that M6P / IGFIIR mRNA transcript levels increased in stellate cells from rats exposed to carbon tetrachloride ( CCl4 ) , a potent fibrogenic stimulant .", "entities": [ "M6P", "IGFIIR", "M6P", "IGFIIR" ] }, { "id": "10339", "type": "gene", "text": "To investigate the regulation of expression of the human mdr1 gene , the response of the mdr1 promoter to signals involved in cell proliferation was examined .", "entities": [ "human mdr1 gene", "mdr1 promoter" ] }, { "id": "12004", "type": "gene", "text": "Clinical studies SY5555 was administered to 45 patients with various infectious diseases ( 2 with acute pharyngitis , 8 with acute tonsillitis , 4 with lacunar tonsillitis , 3 each with acute bronchitis , pneumonia and pertussis , 7 with scarlet fever , 3 with impetigo contagiosa , 6 with acute urinary tract infections , 2 with balanoposthitis and 1 each with cervical lymphadenitis , S . S . S . S . , vulvitis and acute colitis ) at daily doses between 3 . 4 - 10 mg / kg , t . i . d . , for 3 - 14 days .", "entities": [] }, { "id": "4828", "type": "gene", "text": "The results also imply that the absence of perforin expression in non - cytotoxic cells may be due to the suppression of the induction of the killer - cell - specific trans - acting factor NF - P2 .", "entities": [ "perforin", "NF - P2" ] }, { "id": "4487", "type": "gene", "text": "In most cases of acute transmural infarction , the reciprocal ST segment depressions observed in contralateral leads are less marked than the primary ST segment elevations .", "entities": [] }, { "id": "9507", "type": "gene", "text": "This mechanism is not due to the observed grain boundary precipitates .", "entities": [] }, { "id": "11986", "type": "gene", "text": "The range of 200 000 - 300 000 spermatozoa / microl appeared to be a reasonable compromise for both criteria .", "entities": [] }, { "id": "9766", "type": "gene", "text": "We have used these modified assay conditions to extend studies on the transposition pathway .", "entities": [] }, { "id": "6647", "type": "gene", "text": "BACKGROUND : Studies in lean men show poor regulation of energy ( EB ) and fat balance ( FB ) during manipulation of dietary ratios of fat to carbohydrate .", "entities": [] }, { "id": "1779", "type": "gene", "text": "Using an opsonophagocytic bacterial assay and a suckling rat model of GBS sepsis , we analyzed a modified human immunoglobulin for opsonic and protective antibody .", "entities": [ "human immunoglobulin" ] }, { "id": "10226", "type": "gene", "text": "4 Five patients died within one month of captopril and five between four and seven months , three of whom had improved to class IIM and one to IIS before death .", "entities": [] }, { "id": "1184", "type": "gene", "text": "Gonadal dysfunction in patients with ataxia telangiectasia .", "entities": [] }, { "id": "1590", "type": "gene", "text": "Utility of OAE screener ( GSI 70 ) for the evaluation of distortion product otoacoustic emissions ] The purpose of this study was to investigate the ability of the OAE screener GSI 70 to evaluate of cochlea function in neonates , infants and adults .", "entities": [] }, { "id": "1393", "type": "gene", "text": "A 1 - base pair mismatch within the corresponding region of the CYP3A4 gene was sufficient for a differential enhancer activity .", "entities": [ "CYP3A4 gene" ] }, { "id": "838", "type": "gene", "text": "The data obtained up to now only suggest the future potentiality of Bestatin treatment for these types of malignancy .", "entities": [] }, { "id": "6618", "type": "gene", "text": "( 1998 ) FASEB J .", "entities": [] }, { "id": "1141", "type": "gene", "text": "Since September 1980 to June 1983 we have treated 32 patients with ovarian cancer .", "entities": [] }, { "id": "4086", "type": "gene", "text": "RESULTS : The diagnostic quality of FDG images was at least as good as that of their Tl - 201 counterparts , with less liver background in all but one FDG study .", "entities": [] }, { "id": "9628", "type": "gene", "text": "Unilateral naris occlusion and the rat accessory olfactory bulb .", "entities": [] }, { "id": "11171", "type": "gene", "text": "Two BASIC computer programs using logit transformation for the analysis of S - shaped curves are presented .", "entities": [] }, { "id": "8719", "type": "gene", "text": "In transformed E . coli , constitutive CAT expression is maintained when as little as 0 . 3 kilobase of DNA from the 3 ' end of the 1 . 6 - kilobase segment is inserted in the correct orientation in front of the CAT gene .", "entities": [ "constitutive CAT", "CAT gene" ] }, { "id": "1796", "type": "gene", "text": "Ras p21Val inhibits myogenesis without altering the DNA binding or transcriptional activities of the myogenic basic helix - loop - helix factors .", "entities": [ "Ras p21Val", "myogenic basic helix - loop - helix factors" ] }, { "id": "8036", "type": "gene", "text": "The promoter activity was measured by a transient expression of a chloramphenicol acetyltransferase ( CAT ) gene connected with various 5 ' - deletion mutants of the 5 ' - flanking region .", "entities": [ "chloramphenicol acetyltransferase", "CAT" ] }, { "id": "12496", "type": "gene", "text": "In PAV - 3 , the E1A region is located between 1 . 5 and 3 . 8 map units .", "entities": [ "E1A region" ] }, { "id": "9839", "type": "gene", "text": "Changes induced in the gills of milkfish ( Chanos chanos Forsskal ) fingerlings after acute exposure to nifurpirinol ( Furanace ; P - 7138 ) .", "entities": [] }, { "id": "692", "type": "gene", "text": "Because the deletion included the TK gene , selection with gancyclovir against cells not having undergone recombination was possible .", "entities": [ "TK gene" ] }, { "id": "7696", "type": "gene", "text": "RNase protection analyses indicate that either 61 - kDa CaM PDE mRNA or structurally related transcripts encoding different CaM PDE isoforms are expressed in a tissue - specific manner .", "entities": [ "RNase", "61 - kDa CaM PDE mRNA", "CaM PDE isoforms" ] }, { "id": "10253", "type": "gene", "text": "These results suggest that Rho1p regulates cytoskeletal reorganization at least through Bni1p and Pkc1p .", "entities": [ "Rho1p", "Bni1p", "Pkc1p" ] }, { "id": "7814", "type": "gene", "text": "Our results demonstrate the importance of phosphate and calcium in influencing the secretion of PTH and CT in uremia .", "entities": [ "PTH", "CT" ] }, { "id": "6026", "type": "gene", "text": "We show that the 5 ' UTR characteristic of testis - specific c - mos mRNA strongly represses translation relative to the translation of transcripts that contain a 5 ' UTR derived from beta - globin mRNA , and this is mainly due to the four uORFs .", "entities": [ "testis - specific c - mos mRNA", "beta - globin mRNA" ] }, { "id": "7553", "type": "gene", "text": "Biochemical analysis demonstrates that the BJ1 protein is associated with nucleosomes and is released from chromatin by agents which intercalate into DNA , as previously shown for the high mobility group proteins ( HMGs ) .", "entities": [ "BJ1 protein", "high mobility group proteins", "HMGs" ] }, { "id": "7877", "type": "gene", "text": "An InlC deletion mutant shows reduced virulence when tested in an intravenous mouse model , but intracellular replication of the mutant in Caco - 2 and J774 cells appears to be comparable with that of the wild - type strain .", "entities": [ "InlC deletion mutant" ] }, { "id": "276", "type": "gene", "text": "In this study , rabbits were used to evaluate the sutured wound reaction with Dexon or nylon in the conjunctival flap 1 , 4 , 7 , 14 and 28 days after trabeculectomy surgery with or without the use of mitomycin - C .", "entities": [] }, { "id": "10569", "type": "gene", "text": "In addition , a catalytically inactive version of the Src family member , Lck ( lymphoid cell kinase ) , was expressed , purified , and evaluated as a Csk substrate .", "entities": [ "Src family", "Lck", "lymphoid cell kinase", "Csk" ] }, { "id": "1868", "type": "gene", "text": "In addition , depletion of Oct - 1 from the nuclear extract by using Oct - 1 - specific antiserum or a sequence - specific DNA affinity resin decreased in vitro transcription from the wild - type MMTV promoter to a level identical to that obtained from a promoter in which all three octamer - related sequences were mutated .", "entities": [ "Oct - 1", "Oct - 1" ] }, { "id": "11243", "type": "gene", "text": "The genomic structure of brk consists of 8 exons , whose boundaries are distinct from other non - receptor PTK family members , again indicating a structural and functional divergence .", "entities": [ "brk", "PTK family" ] }, { "id": "5684", "type": "gene", "text": "Twenty - five patients ( 80 , 6 % ) with mixed neoplasms were operated on by total conservative parotidectomy ( T . C . P . ) , 3 ( 9 , 7 % ) by S . P . and 3 ( 9 , 7 % ) by En .", "entities": [] }, { "id": "10490", "type": "gene", "text": "Effects of point defects on lattice parameters of semiconductors .", "entities": [] }, { "id": "9136", "type": "gene", "text": "In conclusion , changes in carotid sinus stimulation alters blood flow to the hindlimb through changes in both Pcrit and Ra .", "entities": [] }, { "id": "4906", "type": "gene", "text": "Thus , the B - S mutant does not mimic efficiently the chloroplastic GAPDHs , and long - range and / or second - layer effects , not easily predictable from visual inspection of three - dimensional structures , need to be taken into account for designing a true \" chloroplastic - like \" mutant of cytosolic GAPDH .", "entities": [ "chloroplastic GAPDHs", "cytosolic GAPDH" ] }, { "id": "2211", "type": "gene", "text": "Mean rCBF increased in some patients 4 - 8 weeks after surgery on the ipsilateral side .", "entities": [] }, { "id": "5344", "type": "gene", "text": "Video images of the nostrils were captured and then analyzed for area , perimeter , centroid , principal axis , moments about the major and minor axes ( I11 , I22 ) , anisometry , bulkiness , lateral offset , internostril angle , and rotational angle .", "entities": [] }, { "id": "2361", "type": "gene", "text": "By screening a Y1 cell cDNA library with the DNA - binding region of the H - 2RIIBP nuclear hormone receptor cDNA , we isolated a cDNA that is selectively expressed in steroidogenic cells .", "entities": [ "H - 2RIIBP nuclear hormone receptor cDNA" ] }, { "id": "7835", "type": "gene", "text": "On the basis of size , the CRS sequence to which it binds , and its tentative identification as a zinc finger protein , Adx factor has been identified as a Kruppel - like zinc finger protein ( a mouse ZBP - 89 homologue ) .", "entities": [ "zinc finger protein", "Adx factor", "Kruppel - like zinc finger protein", "mouse ZBP - 89 homologue" ] }, { "id": "3029", "type": "gene", "text": "We conclude that , both in atrial myocytes and in Xenopus oocytes , beta - adrenergic stimulation potentiates the ACh - evoked GIRK channels via a pathway that involves PKA - catalyzed phosphorylation downstream from beta ( 2 ) AR .", "entities": [ "GIRK channels", "PKA", "beta ( 2 ) AR" ] }, { "id": "7061", "type": "gene", "text": "Oligonucleotides , designed on the basis of conserved flanking amino acid sequence segments within the catalytic domain of eukaryotic protein kinase C ( PKC ) proteins , were used as primers for polymerase chain reactions to amplify a 427 - bp chromosomal DNA fragment from the filamentous fungus Trichoderma reesei .", "entities": [ "eukaryotic protein kinase C", "PKC" ] }, { "id": "2691", "type": "gene", "text": "Similarly , co - expression of a dominant - negative mutant of p38alpha , but not of ERK1 , ERK2 , JNK1 , or JNK2 , reduces basal and cadmium - induced pE1 - luc activity .", "entities": [ "p38alpha", "ERK1", "ERK2", "JNK1", "JNK2", "pE1 - luc" ] }, { "id": "273", "type": "gene", "text": "After all doses of d - amphetamine , responding occurred largely on the saline key under both schedules .", "entities": [] }, { "id": "412", "type": "gene", "text": "Restriction enzyme and heteroduplex analyses confirmed that sequences unique to FeSV ( src sequences ) are located at the center of the FeSV genome and are approximately 1 . 5 kilobase pairs in length .", "entities": [ "src sequences" ] }, { "id": "6500", "type": "gene", "text": "METHODS : We obtained maximal inspiratory and expiratory flow - volume curves in 41 unselected patients with essential tremor ( 14 males , 27 females , age 61 . 7 + / - 2 . 14 years ) .", "entities": [] }, { "id": "3567", "type": "gene", "text": "A constitutive allele of GPA2 could stimulate growth of a strain lacking both RAS genes .", "entities": [ "GPA2", "RAS genes" ] }, { "id": "265", "type": "gene", "text": "Finally , using in vitro binding studies , we showed that SREBP2 was able to displace ADD1 / SREBP1 binding from the sterol regulatory element ( SRE ) site .", "entities": [ "SREBP2", "ADD1", "SREBP1" ] }, { "id": "2040", "type": "gene", "text": "To address these questions , a recombinant FRAP / mTOR protein and a FRAP / mTOR immunoprecipitate were utilized in in vitro kinase assays to phosphorylate 4E - BP1 .", "entities": [ "FRAP", "mTOR", "FRAP", "mTOR", "4E - BP1" ] }, { "id": "4247", "type": "gene", "text": "An important mechanism by which the tumor suppressor p53 maintains genomic stability is to induce cell cycle arrest through activation of the cyclin - dependent kinase inhibitor p21 ( WAF1 / Cip1 ) gene .", "entities": [ "p53", "cyclin - dependent kinase", "p21", "WAF1", "Cip1" ] }, { "id": "1199", "type": "gene", "text": "The antioxidant agent pyrrolidine dithiocarbamate ( PDTC ) has been shown to protect endothelial cells ( EC ) from pro - inflammatory - induced and pro - oxidant - induced NF - kappaB activation .", "entities": [ "NF - kappaB" ] }, { "id": "7025", "type": "gene", "text": "Thus , the screen for toxic p53 mutants in yeast can identify novel p53 variants that may be useful in dissecting p53 regulated cellular responses and in developing p53 - based cancer therapies .", "entities": [ "p53 mutants", "p53", "p53", "p53" ] }, { "id": "6868", "type": "gene", "text": "The C - terminal peptide sequences of the human lymphocyte - specific high mobility group ( HMG ) - box transcription factor TCF - 1 are determined by alternative splice mechanisms affecting the exons VIII to X .", "entities": [ "human lymphocyte - specific high mobility group ( HMG ) - box transcription factor TCF - 1" ] }, { "id": "3094", "type": "gene", "text": "Measurements in the LWS p . a .", "entities": [] }, { "id": "10647", "type": "gene", "text": "The well - known Rel / NF - kappaB family of vertebrate transcription factors comprises a number of structurally related , interacting proteins that bind DNA as dimers and whose activity is regulated by subcellular location .", "entities": [ "Rel", "NF - kappaB" ] }, { "id": "6763", "type": "gene", "text": "We show here that the third SH3 domain binds to Sos , a guanine nucleotide exchange factor for Ras and Rac , both in vitro and in vivo .", "entities": [ "SH3 domain", "Sos", "guanine nucleotide exchange factor", "Ras", "Rac" ] }, { "id": "3242", "type": "gene", "text": "Calcitonin simultaneously regulates both periosteal hyperostosis and trabecular osteopenia in the spinal hyperostotic mouse ( twy / twy ) in vivo .", "entities": [ "Calcitonin", "twy", "twy" ] }, { "id": "5924", "type": "gene", "text": "With regard to nonhematologic toxicities , diarrhea , infection and elevated serum alkaline phosphatase of grade 3 or over were observed in 2 % of cycles , but were tolerable and reversible .", "entities": [ "serum alkaline phosphatase" ] }, { "id": "1611", "type": "gene", "text": "The full - length N gene , encoded by open reading frame 7 , was cloned from the Canadian PRRS virus , PA - 8 .", "entities": [ "N gene" ] }, { "id": "10468", "type": "gene", "text": "An association between hSIE and Stat - 3 after MHC - I ligation was directly demonstrated by precipitating Stat - 3 from nuclear extracts with biotinylated hSIE probe and avidin - coupled agarose .", "entities": [ "hSIE", "Stat - 3", "MHC - I", "Stat - 3", "hSIE", "avidin" ] }, { "id": "9891", "type": "gene", "text": "EBER1 mRNA , a consistent marker of viral latency , was positive in all PEL cases , although at lower levels than in the non - PEL controls due to EBER1 expression by only a variable subset of lymphoma cells .", "entities": [ "EBER1 mRNA", "EBER1" ] }, { "id": "1203", "type": "gene", "text": "By far - Western analysis and coimmunoprecipitation studies , we demonstrate that ZNF74 interacts , via its zinc finger domain , with the hyperphosphorylated largest subunit of RNA polymerase II ( pol IIo ) but not with the hypophosphorylated form .", "entities": [ "ZNF74", "RNA polymerase II", "pol IIo" ] }, { "id": "1037", "type": "gene", "text": "We exploit the properties of LexA fusion proteins to study the dimerization and DNA - contacting domains of cRel .", "entities": [ "LexA fusion proteins", "cRel" ] }, { "id": "6447", "type": "gene", "text": "After infection of 293 cells ( which provide complementary E1a - E1b functions ) , both viruses directed equal amounts of P / C - specific mRNA transcription .", "entities": [ "E1a", "E1b", "P / C - specific mRNA" ] }, { "id": "9604", "type": "gene", "text": "Despite this there was no difference in the intubating conditions at one minute with 25 excellent / 5 good in the suxamethonium group and 27 excellent / 3 good in the rocuronium group .", "entities": [] }, { "id": "2577", "type": "gene", "text": "The effects of taloximine and aminophylline on isolated human smooth muscle .", "entities": [] }, { "id": "7345", "type": "gene", "text": "The purpose of this study was to evaluate simplified methods for estimation of Technetium Tc 99m ( 99mTc ) - pentetate and orthoiodohippurate I 131 ( 131I - OIH ) plasma clearance in dogs and cats with 1 and 2 blood samples .", "entities": [] }, { "id": "4357", "type": "gene", "text": "During the following pregnancy ultrasonographic studies of the male fetus in the 16th week of gestation revealed severe micrognathia , short and wide thumbs , and big toes , and bowed tibiae .", "entities": [] }, { "id": "797", "type": "gene", "text": "The major PKC beta transcription initiation site was identified by primer extension and S1 nuclease protection .", "entities": [ "PKC beta", "S1 nuclease" ] }, { "id": "1576", "type": "gene", "text": "Natural and induced malarias in western hemisphere monkeys .", "entities": [] }, { "id": "4099", "type": "gene", "text": "( 3 ) This effect occurs without removing TRs from the TRE .", "entities": [ "TRs" ] }, { "id": "245", "type": "gene", "text": "The GTPase activity of CDC42Ce is moderately stimulated by human n - chimaerin , a GTPase - activating protein for the related p21 rac1 .", "entities": [ "GTPase", "CDC42Ce", "human n - chimaerin", "GTPase - activating protein", "rac1" ] }, { "id": "1124", "type": "gene", "text": "The resurgence of drug - resistant malaria makes urgent the evaluation of new antimalarial agents .", "entities": [] }, { "id": "3389", "type": "gene", "text": "PURPOSE : To evaluate the disease - free survival ( DFS ) and overall survival ( OS ) , prognostic factors , and treatment - related mortality of women with stage IIIB inflammatory breast cancer ( IBC ) treated with combined modality therapy ( CMT ) and high - dose chemotherapy ( HDCT ) with autologous stem - cell transplantation .", "entities": [] }, { "id": "11653", "type": "gene", "text": "[ Ala85 ] Dk ( 69 - 85 ) retains full biological activity .", "entities": [ "[ Ala85 ] Dk ( 69 - 85 )" ] }, { "id": "8661", "type": "gene", "text": "Chlorambucil and interferon for low grade non - Hodgkin ' s lymphoma .", "entities": [ "interferon" ] }, { "id": "4403", "type": "gene", "text": "The smaller uptake rate and faster clearance rate resulted in the lower BCF for SWA killifish .", "entities": [] }, { "id": "11417", "type": "gene", "text": "Against gram - positive organisms , E - 4767 and E - 5065 were , in general , eight - and fourfold more active than tosufloxacin , which is the most potent of the reference compounds .", "entities": [] }, { "id": "4212", "type": "gene", "text": "A 36 - kDa protein that was localized to the membrane fraction was detected in minicells containing plasmids with the ftsN gene , confirming that FtsN was a membrane protein .", "entities": [ "ftsN gene", "FtsN" ] }, { "id": "2828", "type": "gene", "text": "Among 100 cases of post - transfusion hepatitis , 10 are due to the hepatitis B virus ( despite systematic search for HBs Ag ) , 89 are due to one of the non - A non - B viruses ( not detectable by specific serological tests ) and 1 to several viruses , specially CMV .", "entities": [ "HBs Ag" ] }, { "id": "11046", "type": "gene", "text": "The CAPLC1 protein also exhibited several unique features , including a novel stretch of 18 - 19 amino acid residues within the X domain and an unusually long N - terminus which did not contain a recognizable EF - hand Ca ( 2 + ) - binding domain .", "entities": [ "CAPLC1 protein" ] }, { "id": "386", "type": "gene", "text": "Cyclic loading of bone during normal daily activity leads to the formation of microcracks within the tissue matrix of compact bone .", "entities": [] }, { "id": "11970", "type": "gene", "text": "Remarkably , a construct corresponding to residues 631 to 970 , which contains only the LXXLL motifs and the AD1 region of SRC1 , retained strong coactivator activity in our assays .", "entities": [ "SRC1" ] }, { "id": "4895", "type": "gene", "text": "Specifically , they were performed to determine whether detection of envelope phase disparity was consistent with processing within a single channel in which the AM tones were simply added .", "entities": [] }, { "id": "12115", "type": "gene", "text": "Identification of a promoter - specific transactivation domain in the herpes simplex virus regulatory protein ICP4 .", "entities": [ "herpes simplex virus regulatory protein ICP4" ] }, { "id": "5466", "type": "gene", "text": "Conservation of function of Drosophila melanogaster abl and murine v - abl proteins in transformation of mammalian cells .", "entities": [ "Drosophila melanogaster abl", "murine v - abl proteins" ] }, { "id": "8170", "type": "gene", "text": "The effects of cardioselective beta - 1 adrenergic agonist , 1 - ( 4 - hydroxyphenoxy ) - isopropylamino - 2 - propanol ) , i . e . , prenalterol , were examined on direct and continuous measurements of left ventricular ( LV ) pressure , diameter , dP / dt , velocity of shortening , arterial pressure , iliac blood flow and heart rate in 10 conscious dogs .", "entities": [] }, { "id": "8366", "type": "gene", "text": "SCL prolonged promptly after verapamil , and sinus arrest developed in two of 10 group 2 and two of five group 3 animals .", "entities": [] }, { "id": "1644", "type": "gene", "text": "The same ligands also exhibit a similar inhibitory effect on PDGF - BB - dependent [ 3H ] thymidine incorporation in PAE cells expressing the PDGF beta - receptors .", "entities": [ "PDGF - BB", "PDGF beta - receptors" ] }, { "id": "3639", "type": "gene", "text": "Nursing of patients with gynecological diseases", "entities": [] }, { "id": "9078", "type": "gene", "text": "The effect of antilymphocyte sera on formation of transplantation and anti - infection immunity in mice", "entities": [] }, { "id": "2513", "type": "gene", "text": "Fifty min after release from stress , increases in plasma corticosterone levels induced by stress recovered in the biting group but remained high in the non - biting group .", "entities": [] }, { "id": "638", "type": "gene", "text": "In the second case , an epidermal cyst was diagnosed .", "entities": [] }, { "id": "1132", "type": "gene", "text": "Second report of the Norwegian Cancer Society .", "entities": [] }, { "id": "5690", "type": "gene", "text": "The patient was a 78 - year - old male in whom skin lesions preceded the diagnosis of myelofibrosis .", "entities": [] }, { "id": "2537", "type": "gene", "text": "Consistent with this , purified Dlk phosphorylated core histones H3 , H2A and H4 as exogenous substrates and endogenous histone H3 in kinase assays with nuclear extracts .", "entities": [ "Dlk", "histones H3", "H2A", "H4", "histone H3" ] }, { "id": "2493", "type": "gene", "text": "Collectively , these data indicate that HIP is a membrane - associated HP - binding protein expressed on the surface of normal human uterine epithelia and uterine epithelial cell lines .", "entities": [ "HIP", "HP - binding protein" ] }, { "id": "5073", "type": "gene", "text": "High ATP / GTP ratios promoted initiation of RNA primer synthesis at 3 ' - dCTTT sites , whereas low ATP / GTP ratios promoted initiation at 3 ' - dCCC sites .", "entities": [] }, { "id": "6757", "type": "gene", "text": "A protocol is elaborated for the preparation and characterization of a quality control material ( QCM ) containing intrinsic concentration of cadmium ( Cd ) ( 0 . 8 microgram / L ) and lead ( Pb ) ( 13 . 4 micrograms / dL ) from bovine blood and an elevated QCM containing Cd ( 5 . 0 micrograms / L ) , mercury ( Hg ) ( 11 . 2 micrograms / L ) , and Pb ( 34 . 5 micrograms / dL ) from bovine blood spiked with aqueous spiking - solutions prepared with salts of Cd , Hg , and Pb .", "entities": [] }, { "id": "7287", "type": "gene", "text": "Audiological findings in pregnancy .", "entities": [] }, { "id": "7881", "type": "gene", "text": "CONCLUSIONS : Fission yeast SCF is composed of Pop1 and Pop2 , two structurally related but functionally independent F - box / WD - repeat proteins .", "entities": [ "Fission yeast SCF", "Pop1", "Pop2", "F - box / WD - repeat proteins" ] }, { "id": "7521", "type": "gene", "text": "In calves receiving milk - substitute diets containing 80 - 260 g DM / kg , milk intakes were reduced by up to 30 % on the 1st day that calves were fed once daily instead of twice daily .", "entities": [] }, { "id": "8977", "type": "gene", "text": "Modern cancer therapy has included surgery , radiotherapy , chemotherapy , and most recently , immunotherapy and hyperthermia .", "entities": [] }, { "id": "3707", "type": "gene", "text": "Induction of AtP5CS1 mRNA accumulation in salt - treated seedlings involves an immediate early transcriptional response regulated by ABA signalling that is not inhibited by cycloheximide , but abolished by the deficiency of ABA biosynthesis in the aba1 Arabidopsis mutant .", "entities": [ "AtP5CS1 mRNA", "aba1 Arabidopsis mutant" ] }, { "id": "9943", "type": "gene", "text": "The ultrastructure of retinal vessels was examined in three eyes from diabetic patients and two eyes from control subjects .", "entities": [] }, { "id": "3531", "type": "gene", "text": "Toxicity during the therapeutic period was not significant in the study group compared with the historical control , treated with the same regimen without G - CSF .", "entities": [ "G - CSF" ] }, { "id": "7262", "type": "gene", "text": "The responsive region of the alpha 2 ( V ) collagen gene was localized to a fragment including 100 bp of basal promoter and 150 bp of exon 1 sequences , which contained two CRE - like elements .", "entities": [ "alpha 2 ( V ) collagen gene" ] }, { "id": "3748", "type": "gene", "text": "Translation of the coding segment , which was designated MsPRP2 , suggested it encodes a chimeric 40 , 569 Da cell wall protein with an amino - terminal signal sequence , a repetitive proline - rich sequence , and a cysteine - rich carboxyl - terminal sequence homologous to nonspecific lipid transfer proteins .", "entities": [ "MsPRP2" ] }, { "id": "5198", "type": "gene", "text": "Since MEK acts as a cytoplasmic anchor for the ERKs , the lack of a MEK interaction resulted in the aberrant nuclear localization of ERK2 - Delta19 - 25 mutants in serum - starved cells .", "entities": [ "MEK", "ERKs", "MEK", "ERK2", "Delta19 - 25" ] }, { "id": "928", "type": "gene", "text": "More generally , Ets1 and Ets2 could regulate transcription of cellular genes .", "entities": [ "Ets1", "Ets2" ] }, { "id": "9532", "type": "gene", "text": "Subhuman primates appear to be more sensitive to reproductive and other adverse effects of PCBs than humans .", "entities": [] }, { "id": "272", "type": "gene", "text": "The central visual fields of 2165 normal and 106 glaucoma eyes were measured using a threshold related suprathreshold strategy .", "entities": [] }, { "id": "6200", "type": "gene", "text": "Critical study", "entities": [] }, { "id": "3737", "type": "gene", "text": "Transfection and in vitro binding studies identified within HEFT1 a promoter whose basal activity required a GC box activated by Sp1 or Sp3 .", "entities": [ "HEFT1 a promoter", "Sp1", "Sp3" ] }, { "id": "3233", "type": "gene", "text": "In these cells , E2 proteins had little or no stimulatory effect on the transcriptional activity of the HPV - 11 enhancer - SV40 promoter .", "entities": [ "E2 proteins", "HPV - 11 enhancer", "SV40 promoter" ] }, { "id": "4781", "type": "gene", "text": "In contrast , high COUP - TFI expression impeded the neuronal differentiation of P19 cells induced with RA , resulting in cell cultures lacking neurons .", "entities": [ "COUP - TFI" ] }, { "id": "1003", "type": "gene", "text": "Gel retardation assays detected ZiaR - dependent complexes forming with the zia operator - promoter and ZiaR - DNA binding was enhanced by treatment with a metal - chelator in vitro .", "entities": [ "ZiaR", "zia operator - promoter", "ZiaR" ] }, { "id": "479", "type": "gene", "text": "One such mutant also affects the overlapping - 10 hexamer of PR and results in reduced occupancy by both MerR and RNA polymerase , likely as a result of inefficient transcriptional initiation of merR mRNA .", "entities": [ "MerR", "RNA polymerase", "merR mRNA" ] }, { "id": "2206", "type": "gene", "text": "At the time of the seizure , the patient was asked to read a test phrase aloud until it was read correctly and clearly .", "entities": [] }, { "id": "11130", "type": "gene", "text": "Gel mobility shift assays indicated that at least four nuclear proteins with distinct biochemical and binding properties possess the ability to bind the 3 beta I - A element to produce four DNA - protein complexes ( R1 to R4 ) .", "entities": [] }, { "id": "3965", "type": "gene", "text": "The retention index of 201Tl SPECT is a useful indicator of metastatic potential , thereby facilitating the prediction of prognosis , and provides insight into the relationship between 201Tl uptake and malignancy .", "entities": [] }, { "id": "1455", "type": "gene", "text": "Here we show that the type of tyrosine kinase receptor stimulated also participates in the nature of the cAMP effect .", "entities": [ "tyrosine kinase receptor" ] }, { "id": "5124", "type": "gene", "text": "To determine the true molecular identity of SFD , both the 50 - and 57 - kDa polypeptides were directly sequenced .", "entities": [ "SFD" ] }, { "id": "3688", "type": "gene", "text": "Replacement of residues in positions + 3 ( His128Asn ) and + 2 ( Gln155Lys ) of the reading helices of fingers 2 and 3 , respectively , prevented binding .", "entities": [] }, { "id": "2523", "type": "gene", "text": "However , both TPN groups showed a marked increase in activities of liver lysosomal enzymes .", "entities": [ "lysosomal enzymes" ] }, { "id": "556", "type": "gene", "text": "We conclude that the beta - adrenergic agonist , isoproterenol , has little influence on vascular capacitance or liver volume of dogs , unless the hepatic outflow resistance is elevated by agents such as histamine .", "entities": [] }, { "id": "5395", "type": "gene", "text": "Body temperature and overall conductance in the cold appear to be more variable in P .", "entities": [] }, { "id": "7853", "type": "gene", "text": "This study investigated the degree to which racial identity influences Mexican - Americans ' performance on the L , K , and MF scales of the MMPI - 2 .", "entities": [] }, { "id": "7188", "type": "gene", "text": "To gain further insight into the pathogenesis of the adult respiratory distress syndrome ( ARDS ) , the authors studied possible relationships among the activation status of circulating polymorphonuclear neutrophils ( PMN ) , cytokine levels , and the severity of lung injury in 31 patients : 15 with ARDS , 9 with severe pneumonia uncomplicated by ARDS , and 7 mechanically ventilated patients with neither ARDS nor pneumonia .", "entities": [] }, { "id": "11777", "type": "gene", "text": "Most recently , the use of the product of brain weight and clearance has been proposed .", "entities": [] }, { "id": "5105", "type": "gene", "text": "In reperfusion B , only the diabetic group demonstrated a significant increase in IL - 8 concentrations at 1 and 15 min compared to nondiabetics .", "entities": [ "IL - 8" ] }, { "id": "432", "type": "gene", "text": "It has been suggested that members of this protein family exhibit both prolyl isomerase and chaperone activity .", "entities": [ "prolyl isomerase" ] }, { "id": "4883", "type": "gene", "text": "These differences involve specific hydrogen - bonding interactions between the protein and DNA , including guanine N7 sites in the major groove of DNA , and alterations in DNA phosphodiester conformation induced by protein binding .", "entities": [] }, { "id": "12453", "type": "gene", "text": "( 1997 ) Nature 387 , 370 - 376 ) ] , we suggest that the metal fluoride ions replaced phosphate at the two ATP - binding sites of the iron protein , Kp2 .", "entities": [ "Kp2" ] }, { "id": "4869", "type": "gene", "text": "MBI and MMBI showed similar Cmax values , but the former disappeared slower in the serum than the latter and resulted in its larger AUC values .", "entities": [] }, { "id": "6881", "type": "gene", "text": "The effect of anticonvulsants on sodium - potassium - activated ATPase , sodium , and potassim in cortex .", "entities": [ "sodium - potassium - activated ATPase" ] }, { "id": "6366", "type": "gene", "text": "Isolation and characterization of a vinculin cDNA from chick - embryo fibroblasts .", "entities": [ "vinculin cDNA from chick - embryo fibroblasts" ] }, { "id": "5129", "type": "gene", "text": "On Days 1 and 14 , most young and elderly subjects exhibited monoexponential decline in bevantolol plasma concentrations after absorption phase .", "entities": [] }, { "id": "10370", "type": "gene", "text": "The second transcript , rhis4l , is bicistronic .", "entities": [ "rhis4l" ] }, { "id": "2631", "type": "gene", "text": "In order to gain deeper insight into the role of the amino - terminal domain of the p24 ( CA ) protein during viral replication , eight highly conserved proline residues known to promote turns and to terminate alpha - helices within the p24 tertiary structure were replaced by a leucine residue ( P - position - L ) .", "entities": [ "p24", "CA", "p24" ] }, { "id": "1257", "type": "gene", "text": "Pulmonary embolectomy and lung transplantation are the main indications for the use of heart - lung - machine .", "entities": [] }, { "id": "4573", "type": "gene", "text": "Previous transactivation experiments indicated that three amino acids residing in this region , Gly , Ser and Val , appear to be critical for target - site discrimination .", "entities": [] }, { "id": "3594", "type": "gene", "text": "The method is applied to determine aberration constants of a CM300 FEG / UT microscope with correction of the three - fold astigmatism .", "entities": [] }, { "id": "10796", "type": "gene", "text": "Regressing microaneurysms in 5 cases of hepatitis B virus related polyarteritis nodosa .", "entities": [] }, { "id": "10083", "type": "gene", "text": "Effect of noise on CO - induced increases of LAP and GPT activity in the plasma of rats", "entities": [ "LAP", "GPT" ] }, { "id": "1165", "type": "gene", "text": "Therefore , to understand how ErbB1 / ErbB2 signaling contributes to this process , we used the ErbB kinase inhibitor AG1478in ErbB2 - dependent BT - 474 and SKBR - 3 human breast cancer cells .", "entities": [ "ErbB1", "ErbB2", "ErbB kinase", "ErbB2" ] }, { "id": "7783", "type": "gene", "text": "Carcinoembryonic antigen ( CEA ) procedures and clinical evaluation .", "entities": [ "Carcinoembryonic antigen", "CEA" ] }, { "id": "5708", "type": "gene", "text": "Subsequently , we show that the reexpression of the r - PTPeta gene in highly malignant rat thyroid cells transformed by retroviruses carrying the v - mos and v - ras - Ki oncogenes suppresses their malignant phenotype .", "entities": [ "r - PTPeta gene", "v - mos", "v - ras - Ki oncogenes" ] }, { "id": "1317", "type": "gene", "text": "Chronic E - B virus infection terminated in malignant lymphoma : a case report", "entities": [] }, { "id": "7920", "type": "gene", "text": "PRL receptor also activates SHP - 2 , a cytosolic tyrosine phosphatase .", "entities": [ "PRL receptor", "SHP - 2", "cytosolic tyrosine phosphatase" ] }, { "id": "4939", "type": "gene", "text": "Blood eosinophils in patients with Taenia saginata taeniasis .", "entities": [] }, { "id": "11517", "type": "gene", "text": "The average annual cost per head of population was US + 0 X 46 .", "entities": [] }, { "id": "1949", "type": "gene", "text": "It is possible that the patch determines the proper conformation of the site and thereby contributes to recognition indirectly .", "entities": [] }, { "id": "1072", "type": "gene", "text": "Chronic graft - versus - host disease ( cGVHD ) is a major complication of allogeneic hematopoietic cell transplantation .", "entities": [] }, { "id": "1933", "type": "gene", "text": "These results suggested the possibility that the fetus played some role in the production of E3 - 16 - G in early pregnancy .", "entities": [] }, { "id": "5348", "type": "gene", "text": "In Klinefelter ' s syndrome ( 47XXY ) , serum testosterone levels are at the lower end of the normal range and dihydrotestosterone levels are low .", "entities": [] }, { "id": "1919", "type": "gene", "text": "The results obtained are similar to those described with the previous Cremophor formulation although greater variability in induction and recovery times was noted with the emulsion formulation .", "entities": [] }, { "id": "12571", "type": "gene", "text": "Flow cytomery was used for cell cycle analysis .", "entities": [] }, { "id": "9021", "type": "gene", "text": "Several authors have recently reported interference in theophylline analysis by paraxanthine ( 1 , 7 - dimethylxanthine ) , an important metabolite of caffeine .", "entities": [] }, { "id": "7598", "type": "gene", "text": "After determining isoflurane MAC in triplicate , birds were given a mu - opioid agonist ( morphine , n = 9 ) or a kappa - opioid agonist ( U50488H , n = 9 ) .", "entities": [] }, { "id": "2027", "type": "gene", "text": "It can also be used to examine various laryngeal parameters obtained from videotaped endoscopic and stroboscopic examinations .", "entities": [] }, { "id": "1676", "type": "gene", "text": "Hyperactivation of Cdc2 in fission yeast causes cells to undergo a lethal premature mitosis called mitotic catastrophe .", "entities": [ "Cdc2" ] }, { "id": "8737", "type": "gene", "text": "This study examines the cooperative effects of a human estrogen receptor - alpha ( ERalpha ) isoform on estrogen ( E2 ) - mediated gene activation in U2 - OS osteosarcoma cells .", "entities": [ "estrogen receptor - alpha", "ERalpha" ] }, { "id": "3519", "type": "gene", "text": "Isolation of a novel TP53 target gene from a colon cancer cell line carrying a highly regulated wild - type TP53 expression system .", "entities": [ "TP53 target gene", "wild - type TP53" ] }, { "id": "8888", "type": "gene", "text": "Reverse transcription ( RT ) - PCR products were synthesized with two degenerate primers derived from the conserved motifs of various tyrosine kinases .", "entities": [ "tyrosine kinases" ] }, { "id": "7584", "type": "gene", "text": "There was a significant but similar elevation of mean O2 uptake during 40 min postexercise by 13 . 6 % in both the fasted ( p less than 0 . 001 ) and fed state ( p less than 0 . 001 ) .", "entities": [] }, { "id": "8419", "type": "gene", "text": "The requirement of Tyr - 19 dephosphorylation for spindle assembly is also observed under conditions in which spindle formation is independent of mitosis , suggesting that the involvement of Cdc28 / Clb kinase in SPB separation is direct .", "entities": [ "Cdc28", "Clb" ] }, { "id": "8998", "type": "gene", "text": "SPP also induced transient tyrosine phosphorylation of focal adhesion kinase ( p125 ( FAK ) ) , a cytosolic tyrosine kinase that localizes in focal adhesions , and of the cytoskeleton - associated protein paxillin .", "entities": [ "SPP", "focal adhesion kinase", "p125", "FAK", "cytosolic tyrosine kinase", "cytoskeleton - associated protein paxillin" ] }, { "id": "10486", "type": "gene", "text": "Most important , infection of the cells with an adenoviral construct expressing this mutant inhibited the induction of VEGF mRNA under conditions that mimic hypoxia .", "entities": [ "VEGF mRNA" ] }, { "id": "6301", "type": "gene", "text": "Upon serum withdrawal at the permissive temperature , p53 - mediated apoptosis was induced in 50 to 60 % of the cells .", "entities": [ "p53" ] }, { "id": "5171", "type": "gene", "text": "Internally oriented patients ' scores on Rotter ' s Internal - External Locus of Control Scale remained the same over treatment but those of externally oriented patients shifted toward greater internal control .", "entities": [] }, { "id": "164", "type": "gene", "text": "Another tentative hotspot mutation in the third patient , a frame shift caused by a G nucleotide insertion in a monotonous repeat of six Gs in HPRT exon 3 , has been reported previously in three other LN patients .", "entities": [ "HPRT exon 3" ] }, { "id": "771", "type": "gene", "text": "Ultrasound effect on the cytochrome oxidase activity", "entities": [ "cytochrome oxidase" ] }, { "id": "7255", "type": "gene", "text": "In 10 pentobarbitalized dogs , plasma viscosity ( Ep ) was raised fourfold while apparent blood viscosity ( Ea ) increased about twofold by two steps of exchange transfusion of 200 ml of plasma with plasma containing high molecular weight dextran ( mol wt 500 , 000 , 20 % wt / vol ) .", "entities": [] }, { "id": "10071", "type": "gene", "text": "Invited editorial on \" Acute and chronic effects of exercise on leptin levels in humans \" .", "entities": [ "leptin" ] }, { "id": "2401", "type": "gene", "text": "The roll - over test to predict toxemia in pregnancy .", "entities": [] }, { "id": "8724", "type": "gene", "text": "The observed sequence variation disrupts the first ORF in many Y ' s while most of the second ORF including the putative helicase region is unaffected .", "entities": [ "Y", "helicase region" ] }, { "id": "11627", "type": "gene", "text": "Comparison of the plant nuclear tRNA 3 ' processing enzyme with the plant mitochondrial one suggests that both activities are different enzymes .", "entities": [] }, { "id": "762", "type": "gene", "text": "We have investigated the influence of NaFe3 + EDTA , and of increasing dietary levels of Na2EDTA , on Zn , Cu and Ca metabolism in rats fed on Zn - sufficient and Zn - deficient soya - bean - isolate - based diets .", "entities": [] }, { "id": "6903", "type": "gene", "text": "RA - treatment of these transfectants induced morphologic and immunophenotypic maturation , changes in RA - regulated genes , and a G1 cell cycle arrest in a manner similar to parental NT2 / D1 cells .", "entities": [] }, { "id": "9345", "type": "gene", "text": "The influence of patient - related factors on inter - observer variability in the evaluation of neurological signs was investigated .", "entities": [] }, { "id": "3421", "type": "gene", "text": "Comparison to other coxI genes revealed a 966 - bp group I intron , which , based on homology with the related yeast coxI intron aI4 , potentially encodes a 279 - amino - acid site - specific DNA endonuclease .", "entities": [ "coxI genes", "yeast coxI intron aI4", "DNA endonuclease" ] }, { "id": "6817", "type": "gene", "text": "The long terminal repeat ( LTR ) of the human immunodeficiency virus ( HIV ) contains three binding sites for the transcriptional factor Sp1 .", "entities": [ "Sp1" ] }, { "id": "3280", "type": "gene", "text": "Consistent with this finding , wild - type SAGA inhibits TBP binding to the HIS3 promoter in vitro , while SAGA lacking Spt3 or Spt8 is not inhibitory .", "entities": [ "wild - type SAGA", "TBP", "HIS3 promoter", "SAGA", "Spt3", "Spt8" ] }, { "id": "11443", "type": "gene", "text": "Doppler echo in evaluating arteriovenous fistulae for dialysis", "entities": [] }, { "id": "7251", "type": "gene", "text": "A 9 . 5 - kb KpnI - SalI fragment , where all the DNA changes associated with su ( Hw ) mutations were mapped , was able to rescue the su ( Hw ) mutant phenotype after P - element - mediated germ - line transformation .", "entities": [ "KpnI", "SalI", "su ( Hw ) mutations", "su ( Hw ) mutant" ] }, { "id": "11463", "type": "gene", "text": "A single exon encodes the carboxyl - terminal 26 amino acids of the ssd chain and the 3 ' untranslated region of its mRNA , ending with a poly ( A ) - addition site .", "entities": [ "ssd chain" ] }, { "id": "11964", "type": "gene", "text": "We have generated various base substitutions and internal deletions in and around DRE ( nucleotide positions - 93 to - 100 with respect to the transcription initiation site ) of the PCNA gene in vitro and subsequently examined their effects on the binding to DREF ( DRE - binding factor ) and PCNA gene promote activity in cultured Drosophila Kc cells as well as in living flies .", "entities": [ "PCNA gene", "DREF", "DRE - binding factor", "PCNA gene" ] }, { "id": "8614", "type": "gene", "text": "The mucosal defence capacity against proteolytic leukocyte enzymes .", "entities": [] }, { "id": "12263", "type": "gene", "text": "Each repeat consists of 12 nt , coding for the reiterated sequence , K / NPAG .", "entities": [] }, { "id": "4509", "type": "gene", "text": "Although the extracellular domain of the TSH - R is sufficient for high affinity binding of TSH , we conclude that the hyt mutation in the fourth transmembrane domain eliminates TSH binding .", "entities": [ "TSH - R", "TSH", "TSH" ] }, { "id": "1844", "type": "gene", "text": "Losses during the complete procedure are corrected for using radioactive estrogen conjugates during the first steps and later by adding deuterated internal standards of all compounds measured ( matairesinol , enterodiol , enterolactone , daidzein , O - desmethylangolensin , equol , and genistein ) .", "entities": [] }, { "id": "1969", "type": "gene", "text": "At least some of the difference in stability of the two kinds of complexes was due to the fact that the dissociation rate of the A stem substrate from the protein - DNA complexes was approximately fourfold faster than that of the complete TR .", "entities": [ "TR" ] }, { "id": "2846", "type": "gene", "text": "The cytogenetic expression of the folate sensitive fragile site , FRAXE , is due to the expansion of a GCC repeat in proximal Xq28 of the human X chromosome and is associated with a mild form of mental handicap .", "entities": [ "FRAXE" ] }, { "id": "3294", "type": "gene", "text": "Lymphatics in the aorta of rats treated with a soy - bean oil extract ( lipofundin ) .", "entities": [] }, { "id": "384", "type": "gene", "text": "However , C4B proteins encoded by monomodular short genes may have relatively higher concentrations than those from long C4A genes .", "entities": [ "C4B proteins", "long C4A genes" ] }, { "id": "10114", "type": "gene", "text": "The murine MHC class I genes , H - 2Dq and H - 2Lq , are strikingly homologous to each other , H - 2Ld , and two genes reported to encode tumor - specific antigens .", "entities": [ "murine MHC class I genes", "H - 2Dq", "H - 2Lq", "H - 2Ld" ] }, { "id": "3300", "type": "gene", "text": "We show here that the protein kinase MEKK1 can induce reporter gene expression from the atrial natriuretic factor ( ANF ) promoter , a genetic marker that is activated during in vivo hypertrophy .", "entities": [ "MEKK1", "atrial natriuretic factor", "ANF" ] }, { "id": "5223", "type": "gene", "text": "However , ICK1 was induced by ABA , and along with ICK1 induction there was a decrease in Cdc2 - like histone H1 kinase activity .", "entities": [ "ICK1", "ICK1", "histone H1 kinase" ] }, { "id": "3715", "type": "gene", "text": "Selection was based on expression of an integrated DNA fragment containing the con - 10 promoter - regulatory region followed by the initial segment of the con - 10 open reading frame fused in frame with the bacterial hygromycin B phosphotransferase structural gene ( con10 ' - ' hph ) .", "entities": [ "con - 10 promoter - regulatory region", "con - 10 open reading frame", "bacterial hygromycin B phosphotransferase structural gene", "con10 ' - ' hph" ] }, { "id": "7369", "type": "gene", "text": "Observers with brain injury and control participants performed a vigilance task during which they received periodic whiffs of unscented air or air scented with peppermint .", "entities": [] }, { "id": "170", "type": "gene", "text": "The mean extracted concentration of flucloxacillin obtained at operation was 12 . 9 micrograms / ml ( SD 5 . 25 ) in synovial fluid ; 2 . 9 micrograms / g ( SD 3 . 59 ) in synovium ; 2 . 0 micrograms / g ( SD 1 . 48 ) in cancellous bone and 1 . 3 micrograms / g ( SD 1 . 25 ) in cortical bone .", "entities": [] }, { "id": "1780", "type": "gene", "text": "Endoscopic transthoracic sympathectomy as adjuvant treatment for critical upper - limb ischaemia .", "entities": [] }, { "id": "9618", "type": "gene", "text": "The method described may prove useful in studying the physiology of the nasal cycle .", "entities": [] }, { "id": "4238", "type": "gene", "text": "Next , we stably overexpressed wild - type Shc or Y317F mutant Shc into HIRc cells .", "entities": [ "wild - type Shc", "Y317F mutant Shc" ] }, { "id": "12100", "type": "gene", "text": "PATIENTS AND METHODS : One hundred eighty - four chemotherapy - naive patients receiving high - dose cisplatin ( 81 to 120 mg / m2 ) were randomized to receive one of four granisetron doses ( 5 , 10 , 20 , or 40 micrograms / kg ) administered before chemotherapy .", "entities": [] }, { "id": "5527", "type": "gene", "text": "The effects of tap ( TW ) or carbonated ( CW ) water on arterial pH , partial pressure of carbon dioxide ( PCO2 ) and plasma lactate were determined in heat - stressed broilers .", "entities": [] }, { "id": "8889", "type": "gene", "text": "A catalytic domain of eukaryotic DNA topoisomerase I .", "entities": [ "eukaryotic DNA topoisomerase I" ] }, { "id": "10817", "type": "gene", "text": "Progressive 100 - mmHg stepwise decreases in superfusate oxygen partial pressure ( PO2 ) from control ( 95 % O2 aeration , PO2 , 620 - 650 mmHg ) were produced , and subsequent changes in isometric active and resting tension were measured .", "entities": [] }, { "id": "7567", "type": "gene", "text": "The range of serum concentrations , mean values , median values , and standard deviations for each analyte are reported for males and females and for three age groups ( 25 - 44 , 45 - 59 , 60 - 70 ) .", "entities": [] }, { "id": "11660", "type": "gene", "text": "This is based on partitioning an underlying multivariate normal distribution .", "entities": [] }, { "id": "2315", "type": "gene", "text": "The data presented in this work indicate that thi1 may also be involved in DNA damage tolerance in plant cells .", "entities": [ "thi1" ] }, { "id": "917", "type": "gene", "text": "In the IA task , post - training intraperitoneal injections of picrotoxin and bicuculline induced a dose - dependent enhancement of retention measured 24 h after the training , while retention was not affected by bicuculline methiodide ( a GABA receptor antagonist that does not readily cross the blood - brain barrier ) .", "entities": [ "GABA receptor" ] }, { "id": "7499", "type": "gene", "text": "Identification and nucleotide sequence of Rhizobium meliloti insertion sequence ISRm3 : similarity between the putative transposase encoded by ISRm3 and those encoded by Staphylococcus aureus IS256 and Thiobacillus ferrooxidans IST2 .", "entities": [ "Rhizobium meliloti insertion sequence ISRm3", "transposase", "ISRm3", "Staphylococcus aureus IS256", "Thiobacillus ferrooxidans IST2" ] }, { "id": "3420", "type": "gene", "text": "It has been proposed that insulin resistance ( IR ) underlies a cluster of cardiovascular disease ( CVD ) risk factors constituting a \" metabolic syndrome . \" CVD is a leading cause of premature mortality among indigenous Australians .", "entities": [ "insulin" ] }, { "id": "10401", "type": "gene", "text": "Slp1 represses transcription via this binding site in yeast cells , consistent with its role as a direct repressor of ftz stripes in interstripe regions during late stages of embryogenesis .", "entities": [ "Slp1", "ftz" ] }, { "id": "5043", "type": "gene", "text": "This stimulatory effect could also be elicited by c - Jun , which interacts with topo II , but not by c - Fos , which does not bind topo II in our in vitro assay .", "entities": [ "c - Jun", "topo II", "c - Fos", "topo II" ] }, { "id": "3751", "type": "gene", "text": "Calmodulin - binding peptide ( CBP ) , a peptide of 26 amino acids derived from muscle myosin light chain kinase ( MLCK ) , binds to calmodulin with nanomolar affinity .", "entities": [ "Calmodulin - binding peptide", "CBP", "muscle myosin light chain kinase", "MLCK", "calmodulin" ] }, { "id": "8220", "type": "gene", "text": "The investigation was thereafter continued in an open fashion by administering a single 10 mg dose of the MAO - B inhibitor deprenyl to the same subjects .", "entities": [ "MAO - B" ] }, { "id": "2652", "type": "gene", "text": "In Cd - spiked OECD soil , internal Cd levels were linearly related to external Cd concentrations , whereas the springtails maintained fixed internal levels of Cu and Zn regardless of spiked concentrations .", "entities": [] }, { "id": "6767", "type": "gene", "text": "Immunofluorescence microscopy and cell fractionation analyses showed that the 110 - kDa protein was exclusively nuclear , whereas the 150 - kDa protein was present in both the cytoplasm and nucleus of human cells .", "entities": [] }, { "id": "2958", "type": "gene", "text": "It is concluded that suppression of elevated prolactin levels in progressive metastatic breast cancer patients is not effective in restoring tumor sensitivity to chemotherapy .", "entities": [ "prolactin" ] }, { "id": "6737", "type": "gene", "text": "METHODS : Millipore ultrafiltration membranes of three different pore sizes were used as model lenticule materials . The nominal membrane pore sizes were 0 . 1 microm , 0 . 45 microm , and 3 microm ; the surface roughness increased in the same order The membranes were coated with a thin layer of collagen I and implanted in a circular pocket of the anterior cornea of adult cats , and were clinically evaluated for the extent of epithelialization and the persistence of epithelial attachment .", "entities": [ "collagen I" ] }, { "id": "7219", "type": "gene", "text": "No consistent correlation between blood pressure change and SCR - change was seen .", "entities": [] }, { "id": "11260", "type": "gene", "text": "Changes in prognosis of twin births over 20 years .", "entities": [] }, { "id": "12233", "type": "gene", "text": "Anti - hepatitis A virus ( HAV ) titer after vaccination was measured in 83 HIV - positive and 39 HIV - negative men .", "entities": [ "Anti - hepatitis A" ] }, { "id": "306", "type": "gene", "text": "Characterization of the 3 ' ends of the plus - strand DNA fragments reveals ( 1 ) that the upstream fragment is elongated beyond PPT2 creating a plus - strand overlap and ( 2 ) that the majority of plus - strand strong - stop DNA fragments bear a copy of the minus - strand primer binding site in agreement with the accepted model of retroviral genomic RNA reverse transcription .", "entities": [ "PPT2" ] }, { "id": "12301", "type": "gene", "text": "Maternal seizures had occurred during pregnancy in 52 per cent .", "entities": [] }, { "id": "10122", "type": "gene", "text": "Recently , studies of agents that disrupt collagen synthesis and deposition have yielded several new angiogenesis inhibitors .", "entities": [ "collagen" ] }, { "id": "11015", "type": "gene", "text": "CONCLUSION : Human preterm birth is associated with significantly lower progesterone / 17 beta - estradiol ratios than those of women with preterm labor delivered at term .", "entities": [] }, { "id": "426", "type": "gene", "text": "Intracellular recordings were performed on the optic tectum of the carp in vitro .", "entities": [] }, { "id": "10068", "type": "gene", "text": "A careful , radiolabelled tissue - distribution study is warranted to elucidate the complicated metabolic fate of perhexiline .", "entities": [] }, { "id": "1720", "type": "gene", "text": "Pentane and ethane , which arise during lipid peroxidation in vivo , were measured by gas chromatography in breath samples of rats fed for 8 weeks a vitamin E - deficient diet to which had been added 0 , 11 , or 40 IU vitamin E acetate per kg .", "entities": [] }, { "id": "9545", "type": "gene", "text": "All 33 subjects were given psychometric instruments for measuring various components of anger and anxiety : Spielberger ' s State - Trait Personality Inventory , the Anger Expression Scale , and the State Anger Reaction Scale .", "entities": [] }, { "id": "7430", "type": "gene", "text": "HS inducibility required the HSE which was bound by HS transcription factor - 1 ( HSF - 1 ) present in extracts prepared from cells exposed to HS .", "entities": [ "HS transcription factor - 1", "HSF - 1" ] }, { "id": "2762", "type": "gene", "text": "The results strengthen the conclusion that predominantly dynamic activity increases the G4 content of mature innervated fast muscles .", "entities": [ "G4" ] }, { "id": "9829", "type": "gene", "text": "Current status of zinc deficiency in the pathogenesis of neurological , dermatological and musculoskeletal disorders .", "entities": [] }, { "id": "1499", "type": "gene", "text": "Serum leptin concentrations in women during gonadotropin stimulation cycles .", "entities": [ "leptin", "gonadotropin" ] }, { "id": "6316", "type": "gene", "text": "Responses of TLD Mg2SiO4 : Tb and radiophotoluminescent glass to heavy charged particles and space radiation .", "entities": [] }, { "id": "3278", "type": "gene", "text": "The predicted amino acid sequence exhibited 70 % identity to that of Bacillus stearothermophilus TyrTS and 55 % identity to that of E . coli TyrTS , while identity to a second cryptic B . subtilis TyrTS gene , designated tyrZ , was only 27 % .", "entities": [ "Bacillus stearothermophilus TyrTS", "E . coli TyrTS", "B . subtilis TyrTS gene", "tyrZ" ] }, { "id": "5226", "type": "gene", "text": "Problems remain to be resolved in the area of quantitative risk assessment .", "entities": [] }, { "id": "6581", "type": "gene", "text": "The results suggest that the presence or absence per se of keratan sulfate on native G1 - G2 does not affect the activity of atrolysin C toward the two sites .", "entities": [] }, { "id": "10574", "type": "gene", "text": "This intron occupies a conserved position corresponding to that of intron 1 in the transit peptide region of chloroplast GAPDH genes ( GapA and GapB ) of higher plants .", "entities": [ "chloroplast GAPDH genes", "GapA", "GapB" ] }, { "id": "11819", "type": "gene", "text": "Gas6 contains an NH2 - terminal Gla domain followed by four epidermal growth factor - like repeats and tandem globular ( G ) domains .", "entities": [ "Gas6", "epidermal growth factor - like repeats" ] }, { "id": "2933", "type": "gene", "text": "The Fis protein regulates site - specific DNA inversion catalyzed by a family of DNA invertases when bound to a cis - acting recombinational enhancer .", "entities": [ "Fis protein", "DNA invertases" ] }, { "id": "3270", "type": "gene", "text": "Antenatal diagnosis of haematological disorders - - ' 1978 ' .", "entities": [] }, { "id": "8589", "type": "gene", "text": "The cloned genes were identified in genetic libraries by hybridization screening using four deoxyoligonucleotide probes which corresponded to the partial amino acid sequence of the purified enzyme .", "entities": [] }, { "id": "11365", "type": "gene", "text": "Effects of alcoholism on the family", "entities": [] }, { "id": "7908", "type": "gene", "text": "Hepatitis B and liver transplantation .", "entities": [] }, { "id": "10172", "type": "gene", "text": "Preliminary report .", "entities": [] }, { "id": "4683", "type": "gene", "text": "To test promotor function , chimeric genes were constructed linking fragments of chicken IGF - I 5 ' - flanking DNA to a promoterless reporter plasmid .", "entities": [ "IGF - I" ] }, { "id": "5355", "type": "gene", "text": "In this situation the convlusion threshold for the 8 substances is as follows : pethidine 20 mg . kg - 1 I . V . , piritramide 30 , morphine 180 , phenoperidine 4 , R 39 209 5 , fentanyl 4 , sufentanil 4 and R 34 995 10 mg . kg - 1 I . V .", "entities": [] }, { "id": "4201", "type": "gene", "text": "Regulation of HIV - 1 transcription .", "entities": [] }, { "id": "1775", "type": "gene", "text": "Cross - reaction between a monoclonal antibody and two alpha beta T cell receptors .", "entities": [ "alpha beta T cell receptors" ] }, { "id": "10202", "type": "gene", "text": "These data demonstrate that DMVA does not cause more myocardial trauma than CPB when used to provide resuscitative circulatory support .", "entities": [] }, { "id": "10170", "type": "gene", "text": "Coronary T1 and T2 weighted images were obtained .", "entities": [] }, { "id": "1855", "type": "gene", "text": "This promoter could direct the constitutive expression of the reporter beta - galactosidase at high frequency in transfected colonies of transformed cells that express L - plastin constitutively ; by contrast , this promoter was virtually inactive in transfected colonies of normal fibroblasts and it exhibited a low frequency of constitutive activation in transfected colonies of in vitro SV40 - transformed fibroblasts which did not exhibit L - plastin expression .", "entities": [ "beta - galactosidase", "L - plastin", "L - plastin" ] }, { "id": "4110", "type": "gene", "text": "Parodoxical rise in urinary albumin levels after treatment of essential hypertension .", "entities": [ "urinary albumin" ] }, { "id": "5328", "type": "gene", "text": "Lipiodol was covalently conjugated with EDTB .", "entities": [] }, { "id": "9447", "type": "gene", "text": "4 ) PU and PD lacked the canonical TATA or CAAT motifs , and are AT - rich .", "entities": [ "PU", "PD" ] }, { "id": "8051", "type": "gene", "text": "The activation and injury of endothelial cells induced by TNF and other proinflammatory cytokines may underlie the local effects of these mediators in vivo .", "entities": [ "TNF" ] }, { "id": "5860", "type": "gene", "text": "In this paper the tyrosine dephosphorylating enzymes , the protein - tyrosine phosphatases ( PTPs ) , are studied which can be grouped into two subfamilies , the soluble PTPs and the receptor PTPs ( RPTPs ) .", "entities": [ "protein - tyrosine phosphatases", "PTPs", "soluble PTPs", "receptor PTPs", "RPTPs" ] }, { "id": "1125", "type": "gene", "text": "Comparison of transmembrane and cytoplasmic domains to a third cell - surface proteoglycan , 48K5 from human lung fibroblasts ( Marynen , P . , Zhang , J . , Cassiman , J . , Vanden Berghe , H . , and David , C .", "entities": [ "48K5" ] }, { "id": "12286", "type": "gene", "text": "It has been shown in an animal experiment that alterations of the renal vasculature and parenchyma after hemostasis performed by Infrared - Contact - Coagulation are best shown by intravital magnification angiography ( magnification factor 2 . 22 ) .", "entities": [] }, { "id": "1620", "type": "gene", "text": "Structural changes in the C - terminus of Ca2 + - bound rat S100B ( beta beta ) upon binding to a peptide derived from the C - terminal regulatory domain of p53 .", "entities": [ "rat S100B", "beta beta", "p53" ] }, { "id": "633", "type": "gene", "text": "Metal coordination compounds of thiabendazole .", "entities": [] }, { "id": "751", "type": "gene", "text": "The carboxyl - terminal portion of UKLF contains three zinc fingers of the Cys2 - His2 type and binds in vitro to the CACCC motif of the beta - globin promoter and to the Sp1 recognition sequence .", "entities": [ "UKLF", "beta - globin promoter", "Sp1 recognition sequence" ] }, { "id": "4043", "type": "gene", "text": "The complete exon - intron organization of the murine gene encoding M - protein , a structural protein of sarcomeric myofibrils , was determined .", "entities": [ "M - protein" ] }, { "id": "5035", "type": "gene", "text": "Its transcription in vitro by pol III requires the same factors as the U6 gene with the major exception that the modified TATA - box of this construct only interacts with a TATA - binding protein ( TBP ) mutant ( TBP - DR2 ) but not with TBP wild - type ( TBPwt ) .", "entities": [ "pol III", "U6 gene", "TATA - binding protein", "TBP", "TBP - DR2", "TBP wild - type", "TBPwt" ] }, { "id": "4613", "type": "gene", "text": "The proposed algorithm consists of several steps .", "entities": [] }, { "id": "9373", "type": "gene", "text": "Phase II study of paclitaxel and oral etoposide in patients with locally advanced or metastatic non - small cell lung cancer .", "entities": [] }, { "id": "8535", "type": "gene", "text": "Using immunolocalization , we observe that ACE3 , a 440 - bp chorion element that contains information sufficient to drive amplification , directs DmORC localization in follicle cells .", "entities": [ "ACE3", "DmORC" ] }, { "id": "7445", "type": "gene", "text": "mTGRRE1 contains three hexanucleotide half - sites ( two canonical and one non - canonical ) in a DR7 / DR5 motif that bind both RAR * RXR heterodimers and RXR homodimers .", "entities": [ "DR7", "DR5", "RAR", "RXR", "RXR homodimers" ] }, { "id": "6667", "type": "gene", "text": "Testing blood donors for non - A , non - B hepatitis : irrational , perhaps , but inescapable .", "entities": [] }, { "id": "3110", "type": "gene", "text": "Identification and characterization of specific DNA - binding complexes containing members of the Myc / Max / Mad network of transcriptional regulators .", "entities": [ "Myc", "Max", "Mad" ] }, { "id": "936", "type": "gene", "text": "We propose that the reduced responsiveness of CYP3A2 is the result of preferential binding of COUP - TF at the CYP3A2 DexRE - 1 site .", "entities": [ "CYP3A2", "COUP - TF", "CYP3A2 DexRE - 1 site" ] }, { "id": "1148", "type": "gene", "text": "We showed that Stat3 and Stat3beta were affinity purified using phosphopeptides containing Y704 and Y744 but not by nonphosphorylated peptide analogues or by phosphopeptides containing Y729 and Y764 .", "entities": [ "Stat3", "Stat3beta" ] }, { "id": "1450", "type": "gene", "text": "The C - terminal mutants were strongly dominant over TraR , suggesting that they can form heteromultimers with the wild - type activator .", "entities": [ "TraR" ] }, { "id": "12543", "type": "gene", "text": "In addition , the megabase region surrounding the dagA locus was mapped .", "entities": [ "dagA locus" ] }, { "id": "3891", "type": "gene", "text": "Homodimers of the three proteins specifically recognize the G - box motif , with GBF1 and GBF3 binding symmetrically to this palindromic sequence .", "entities": [ "GBF1", "GBF3" ] }, { "id": "3752", "type": "gene", "text": "The full protocol was completed by 33 patients ( 45 % of original cohort ) .", "entities": [] }, { "id": "4557", "type": "gene", "text": "Susceptibility to ischemia - induced arrhythmias was lower in 1 - week diabetics : only 42 % of diabetic hearts exhibited ventricular tachycardia ( VT ) and 16 % had short episodes of ventricular fibrillation ( VF ) as compared to VT 100 % and VF 70 % ( including sustained VF 36 % ) in the non - diabetics ( P < 0 . 05 ) .", "entities": [] }, { "id": "1231", "type": "gene", "text": "Interestingly , virions also contained smaller proteins that reacted with antibodies specific for the accessory proteins as well as SN and CAT fusion partners .", "entities": [ "SN", "CAT fusion" ] }, { "id": "11174", "type": "gene", "text": "Members of the titin / myosin light chain kinase family play an essential role in the organization of the actin / myosin cytoskeleton , especially in sarcomere assembly and function .", "entities": [ "titin", "myosin light chain kinase", "actin", "myosin" ] }, { "id": "6161", "type": "gene", "text": "There was significant correlation of LVM / M2 and PWVn for pre - AVR and post AVR studies .", "entities": [] }, { "id": "8134", "type": "gene", "text": "The role of calcitonin , and other agonists which activate the cAMP pathway , in regulating transcription of the human parathyroid hormone - related protein ( PTHrP ) gene was investigated in a human lung cancer cell line ( BEN ) .", "entities": [ "calcitonin", "human parathyroid hormone - related protein", "PTHrP" ] }, { "id": "3179", "type": "gene", "text": "The RAD18 gene open reading frame encodes a protein of 487 amino acids , with a calculated molecular weight of 55 , 512 .", "entities": [ "RAD18 gene open reading frame" ] }, { "id": "10081", "type": "gene", "text": "In addition , there was a significant increase in postdexamethasone cortical concentrations with age ( p less than 0 . 01 ; r = 0 . 31 ) .", "entities": [] }, { "id": "1277", "type": "gene", "text": "Characteristics of lipase activity .", "entities": [ "lipase" ] }, { "id": "3818", "type": "gene", "text": "The marker orders from the genetic and RH maps were consistent .", "entities": [] }, { "id": "1947", "type": "gene", "text": "Patients with apparently minor CT abnormalities may have significant epidural disease .", "entities": [] }, { "id": "11146", "type": "gene", "text": "The transactivation function of EBNA2 was also observed in the HeLa epithelial cell line , which suggests that EBV and HIV - 1 infection of non - B cells may result in HIV - 1 promoter activation .", "entities": [ "EBNA2", "HIV - 1 promoter" ] }, { "id": "1226", "type": "gene", "text": "Antileukoproteinase ( ALP ) is a low mol wt mucosal secretory protein which , in human tissues , inhibits the activities of the neutral serine lysosomal proteinases elastase and cathepsin - G .", "entities": [ "Antileukoproteinase", "ALP", "elastase", "cathepsin - G" ] }, { "id": "5946", "type": "gene", "text": "Multi drug regimens like C - MOPP , CHOP and BACOP led to high remission rates and in some cases probably also to a cure of the disease .", "entities": [] }, { "id": "12315", "type": "gene", "text": "A variety of nuclear ribonucleoproteins are believed to associate directly with nascent RNA polymerase II transcripts and remain associated during subsequent nuclear RNA processing reactions , including pre - mRNA polyadenylation and splicing as well as nucleocytoplasmic mRNA transport .", "entities": [ "RNA polymerase II transcripts" ] }, { "id": "10597", "type": "gene", "text": "Factors associated with afterdrop included age , end - of - surgery temperature ( both positively ) and body mass ( negatively ) .", "entities": [] }, { "id": "6381", "type": "gene", "text": "Nernst - - Planck analog equations and stationary state membrane electric potentials .", "entities": [] }, { "id": "3708", "type": "gene", "text": "The eluent from the column was mixed with the chemiluminescent solution containing lucigenin and Triton X - 100 and a 0 . 28 M KOH solution by pumps and monitored by a chemiluminescence detector .", "entities": [ "lucigenin" ] }, { "id": "4317", "type": "gene", "text": "Phosphatidylinositol 3 - kinase potentiates , but does not trigger , T cell proliferation mediated by the IL - 2 receptor .", "entities": [ "Phosphatidylinositol 3 - kinase", "IL - 2 receptor" ] }, { "id": "11085", "type": "gene", "text": "Allergy and Tourette ' s syndrome .", "entities": [] }, { "id": "704", "type": "gene", "text": "The role of pharmacological profiling in safety assessment .", "entities": [] }, { "id": "10856", "type": "gene", "text": "In both these respects , however , the DBP mRNA resembles the late messengers of SV40 and polyoma viruses .", "entities": [ "DBP mRNA" ] }, { "id": "589", "type": "gene", "text": "PURPOSE : The purposes of the present study were to assess the effects of a 12 - wk laboratory based aerobic exercise program on cardiopulmonary function , CD4 cell count , and physician - assessed health status among symptomatic pre - AIDS HIV - infected individuals ( N = 28 ) and to assess the degree to which ill health was associated with exercise relapse .", "entities": [ "CD4" ] }, { "id": "7688", "type": "gene", "text": "This sequence possessed homology with a methylation - sensitive promoter element , Enh2 , present in the LTR of mouse intractisternal A - particles .", "entities": [] }, { "id": "5564", "type": "gene", "text": "We show here that the binding of C1F in vitro is sensitive to the concentration of calcium ions .", "entities": [ "C1F" ] }, { "id": "7105", "type": "gene", "text": "Inactivation of Ulp2 also suppresses several ulp1 ( ts ) defects , and the double mutant accumulates far fewer Smt3 - protein conjugates than either single mutant .", "entities": [ "Ulp2", "ulp1 ( ts )", "Smt3 - protein" ] }, { "id": "6616", "type": "gene", "text": "Insulin stimulation promoted the association of mIRS3 with p85 , SHP2 , Nck , and Shc .", "entities": [ "Insulin", "mIRS3", "p85", "SHP2", "Nck", "Shc" ] }, { "id": "3353", "type": "gene", "text": "When transfected into Drosophila SL - 2 cells , pCAT plasmid containing 2 , 090 bp of 5 ' - flanking region shows a 3 . 0 - to 3 . 5 - fold increase in chloramphenicol acetyltransferase activity after induction with retinoic acid and / or 8 - bromo - cAMP .", "entities": [ "chloramphenicol acetyltransferase" ] }, { "id": "3191", "type": "gene", "text": "PURPOSE : To determine the effects of hypercholesterolemia and atherosclerosis - induced chronic cavernosal arterial insufficiency on cavernosal smooth muscle tone , nitric oxide synthase ( NOS ) activity and cavernosal tissue synthesis of constrictor eicosanoids .", "entities": [ "nitric oxide synthase", "NOS" ] }, { "id": "4808", "type": "gene", "text": "In this report , almost 6 kb of DNA sequence is presented , including 1251 bp 5 ' to the gene , over 4 kb of exon and exon - intron junctions , and 583 bp 3 ' to the gene .", "entities": [] }, { "id": "11310", "type": "gene", "text": "This scFv was therefore used as control in experiments where another anti - Ras scFv ( Y259 scFv , derived from the neutralizing anti - Ras mAb Y13 - 259 ) blocked the Ras pathway in vitro and led to tumor regression in a nude mouse model [ Cochet , O . , Kenigsberg , M . , Delumeau , I . , Virone - Oddos , A . , Multon , M . C . , Fridman , W . H . , Schweighoffer , F . , Teillaud , J . L . , Tocque , B . , 1998 .", "entities": [ "anti - Ras scFv", "Y259 scFv", "anti - Ras mAb Y13 - 259", "Ras" ] }, { "id": "9503", "type": "gene", "text": "SPA from PAG sites was associated with aversion .", "entities": [] }, { "id": "3406", "type": "gene", "text": "Two additional cis - acting sequences , conserved in both the region 1 and 3 promoters , were identified , suggesting a role for these sequences in the coordinate regulation of transcription from these promoters .", "entities": [] }, { "id": "4589", "type": "gene", "text": "Through transient transfection of NIH3T3 fibroblast cells and gel mobility shift assays , the functional binding site was localized to a short region ( - 318 to - 303 bp from the transcription start site ) which has a CTCCC sequence .", "entities": [] }, { "id": "3445", "type": "gene", "text": "This effect and the fact that all three doses were toxic to the dams dictated that a second experiment be carried out at lower doses .", "entities": [] }, { "id": "12147", "type": "gene", "text": "Further analysis of AP - 1 DNA binding activities in 7 - to 14 - day culture activated HSCs led to the discovery of high mobility AP - 1 complexes ( HMAP - 1 ) .", "entities": [ "AP - 1", "high mobility AP - 1 complexes", "HMAP - 1" ] }, { "id": "813", "type": "gene", "text": "The spectrum of histologically diagnosed malignant neoplasms in Sabah , 1983 - 1988 .", "entities": [] }, { "id": "9483", "type": "gene", "text": "OBJECTIVE : The purpose of this article is to review balance instruments developed within the past 10 years that can be used in the clinic or home environment .", "entities": [] }, { "id": "3782", "type": "gene", "text": "Psychological examinations in patients with chronic kidney insufficiency", "entities": [] }, { "id": "1847", "type": "gene", "text": "We conclude that grade III BGCT can be treated by modified intralesional excision provided the articular surfaces and part of the metaphysis are intact .", "entities": [] }, { "id": "11104", "type": "gene", "text": "Phosphorylation of tyrosine residues in the kinase domain and juxtamembrane region regulates the biological and catalytic activities of Eph receptors .", "entities": [ "Eph receptors" ] }, { "id": "4021", "type": "gene", "text": "PURPOSE : To evaluate treatment and patient related prognostic factors that may influence local control in the treatment of T1 - T2 squamous cell carcinoma of the glottic larynx .", "entities": [] }, { "id": "6541", "type": "gene", "text": "Anti - anxiety action of diazepam after intra - amygdaloid application in the rat .", "entities": [] }, { "id": "8652", "type": "gene", "text": "The factor designated B formed a complex centered on the sequence TGTGGT , a core motif recognized by members of the AML / CBFalpha transcription factor family .", "entities": [ "AML / CBFalpha transcription factor family" ] }, { "id": "12559", "type": "gene", "text": "These thyroid hormone changes may be mediated in part by cytokines or other inflammatory mediators , acting at the level of the hypothalamus and pituitary gland , the thyroid gland , and the hepatic deiodinase system .", "entities": [ "hepatic deiodinase" ] }, { "id": "12227", "type": "gene", "text": "Measurements included bone mineral density of the lumbar spine and proximal femur ( by dual - energy X - ray absorptiometry ) and biochemical markers of bone remodeling ( serum bone - specific alkaline phosphatase by immunoassay and urine deoxypyridinoline by high - pressure liquid chromatography ) .", "entities": [ "alkaline phosphatase" ] }, { "id": "5736", "type": "gene", "text": "These findings suggest that direct cDNA mapping using fluorescence in situ hybridization provides an accurate and rapid approach to the definition of a transcribed map of the human genome .", "entities": [] }, { "id": "238", "type": "gene", "text": "n .", "entities": [] }, { "id": "309", "type": "gene", "text": "The authors made an analysis of social - economical conditions limiting the possibilities of rendering cardiosurgical care to children .", "entities": [] }, { "id": "10470", "type": "gene", "text": "These clones were found to share a common domain encoded by p ( CA ) n repeats ; a simple sequence length polymorphism ( SSLP ) .", "entities": [] }, { "id": "1783", "type": "gene", "text": "In all other cases , vestibular neurectomy or chemical vestibular labyrinthectomy , by means of intratympanic low concentration gentamicin ( 20 mg / mL ) , are indicated .", "entities": [] }, { "id": "7841", "type": "gene", "text": "The predominant binding activity was not Ets - 1 but rather two independent DNA - protein complexes that comigrated in mobility shift assays .", "entities": [ "Ets - 1" ] }, { "id": "10477", "type": "gene", "text": "Thus , ZNF74 sublocalization in nuclear domains enriched in pre - mRNA maturating factors , its RNA binding activity , and its direct phosphodependent interaction with the pol IIo , a form of the RNA polymerase functionally associated with pre - mRNA processing , suggest a role for this member of the KRAB multifinger protein family in RNA processing .", "entities": [ "ZNF74", "pol IIo", "RNA polymerase", "KRAB multifinger protein family" ] }, { "id": "2066", "type": "gene", "text": "These results demonstrate that EKLF provides a crucial transactivation function for globin expression and further reinforce the idea that EKLF is an important regulator of CACCC element - directed transcription in erythroid cells .", "entities": [ "EKLF", "globin", "EKLF" ] }, { "id": "7043", "type": "gene", "text": "The cleavage site between VPg and RNA dependent RNA polymerase was predicted to be E445 - T446 based on the amino acid sequence analysis of the polyprotein from different sobemoviruses .", "entities": [ "VPg", "RNA dependent RNA polymerase" ] }, { "id": "3802", "type": "gene", "text": "After 6 months , definite improvement in strength occurred in 4 of 7 carnitine - treated patients and in none of 7 controls .", "entities": [] }, { "id": "7417", "type": "gene", "text": "Re - examination of the ED01 study .", "entities": [] }, { "id": "1065", "type": "gene", "text": "In addition , carp JAK1 shows higher sequence homology to mammalian JAK1 in both the kinase - like ( JH2 ) and kinase ( JH1 ) domains ( approximately 70 % identity ) .", "entities": [ "carp JAK1", "mammalian JAK1", "JH2", "JH1" ] }, { "id": "7243", "type": "gene", "text": "We have cloned a novel mouse protein , TAF ( II ) 140 , containing an HFD and a plant homeodomain ( PHD ) finger , which we demonstrated by immunoprecipitation to be a mammalian TFIID component .", "entities": [ "TAF ( II ) 140", "HFD", "plant homeodomain", "PHD", "mammalian TFIID component" ] }, { "id": "10373", "type": "gene", "text": "We have cloned and sequenced a region encoding a lipase operon and a putative , previously uncharacterized metalloprotease of Vibrio cholerae O1 .", "entities": [ "lipase operon", "metalloprotease of Vibrio cholerae O1" ] }, { "id": "2737", "type": "gene", "text": "In contrast , rats receiving U74500A ( 2 mg / kg i . v . infusion commencing 30 min prior to revascularisation ) exhibited enhanced GMBF throughout reperfusion [ PI 10 min : 3 . 26 ( 2 . 56 - 3 . 63 ) ; 120 min : 2 . 03 ( 1 . 73 - 2 . 25 ) ; 240 min : 2 . 13 ( 1 . 75 - 2 . 44 ) , p < 0 . 01 vs . controls and normals ] with complete muscle salvage [ GMV 100 % in all reperfused muscles , p < 0 . 01 vs . controls , not significant ( NS ) vs . normals and 6 h ischaemia ] . ( ABSTRACT TRUNCATED AT 250 WORDS )", "entities": [] }, { "id": "4946", "type": "gene", "text": "The cellular sequences 5 ' to the viral integration site exhibited 85 to 97 % identity to several sequences belonging to the mouse L1 family of long interspersed repetitive sequences .", "entities": [ "mouse L1 family" ] }, { "id": "3698", "type": "gene", "text": "OUTCOME : Acetylcholine receptor antibodies and single - fibre electromyogram were useful in the diagnosis of myasthenia gravis .", "entities": [ "Acetylcholine receptor antibodies" ] }, { "id": "9050", "type": "gene", "text": "Separate experiments measured AIB and 86RbCl uptake in 36B - 10 cells in vitro 1 and 2 days following 20 Gy irradiation to assess whether this radiation dose reduced the capacity of tumor cells to trap AIB or Rb + .", "entities": [] }, { "id": "6929", "type": "gene", "text": "A case report with angiographic follow - up study .", "entities": [] }, { "id": "10527", "type": "gene", "text": "The effectiveness of alpha - mercapto - beta - ( 2 - furyl ) acrylic acid ( MFA ) and N - benzyl - N - dithiocarboxy - D - glucamine ( NaB ) , used in combination , in the mobilization and excretion of lead was investigated in rats .", "entities": [] }, { "id": "11665", "type": "gene", "text": "Although differences were not significant , infants in the experimental group had more changes in the intermittent mandatory ventilation ( IMV ) settings during transport , and more such infants arrived at the receiving hospital with acceptable pH and PCO2 values .", "entities": [] }, { "id": "336", "type": "gene", "text": "Epithelial nerve fiber defects included absence or distorted architecture of the basal epithelial plexus and intra - epithelial terminals .", "entities": [] }, { "id": "3087", "type": "gene", "text": "The extraordinary stability of peptide - - gp96 complexes and the plasticity of the peptide - binding pocket support the proposed relay of diverse peptides to MHC and / or other molecules via molecular recognition .", "entities": [ "peptide - - gp96 complexes", "MHC" ] }, { "id": "842", "type": "gene", "text": "OND 8 mg tid days 2 - 3 , and 8 mg tid prn days 4 - 5 and prednisolone 75 - 100 mg qds days 2 - 5 and 2 ) MCP 30 mg / metylprednisolone 80 mg i . v . before CT and MCP 20 mg p . r . after 4 and 8 h respectively .", "entities": [] }, { "id": "3819", "type": "gene", "text": "Additionally , I kappa B beta , but not I kappa B alpha , also prevented the binding of Rel to the kappa B site .", "entities": [ "I kappa B beta", "I kappa B alpha", "Rel", "kappa B site" ] }, { "id": "10126", "type": "gene", "text": "Results demonstrated that the presence of myofibroblasts varied considerably from case to case and was always related to smooth muscle cell dispersion , which occurred around medium - sized damaged portal vein branches .", "entities": [] }, { "id": "9802", "type": "gene", "text": "Moreover , when added to the osteoclast cultures , mrIhh - N markedly stimulated the formation of resorption pits on dentine slices .", "entities": [ "mrIhh - N" ] }, { "id": "7692", "type": "gene", "text": "The future of research with interferon may be divided into three areas : Efforts must be made to determine how best to translate the in vitro synergy into clinically meaningful terms ; in order to exploit the fullest potential of IFN , research is moving toward using this agent earlier in disease either as an adjuvant after tumor debulking or after initial diagnosis ; the medical community must rethink the natural history of some diseases , because the fullest potential of the biologic agents will most likely manifest itself when these agents are used together .", "entities": [ "interferon", "IFN" ] }, { "id": "3368", "type": "gene", "text": "However , mutations in the HNF - 4 binding site on element CIIB and inhibition of HNF - 4 synthesis in HepG2 cells by antisense HNF - 4 constructs decreased the apoCII promoter activity to 25 - 40 % of the control , indicating that HNF - 4 is a positive regulator of the apoCII gene .", "entities": [ "HNF - 4 binding site", "element CIIB", "HNF - 4", "HNF - 4 constructs", "apoCII promoter", "HNF - 4", "apoCII gene" ] }, { "id": "1298", "type": "gene", "text": "Fifty six young patients ( age < 45 yr ) with doppler - proven DVT were investigated for the presence of resistance to activated protein C ( APC - R ) , lupus anticoagulant ( LA ) , anticardiolipin antibodies and deficiencies of protein C , protein S , ATIII activities .", "entities": [ "activated protein C", "APC - R", "anticardiolipin antibodies", "protein C", "protein S", "ATIII" ] }, { "id": "6023", "type": "gene", "text": "The most common types of malformations were eye defects and open coeloms .", "entities": [] }, { "id": "8760", "type": "gene", "text": "The addition of an equimolar complex of the fourth and seventh largest subunits , purified from pol II holoenzyme by ion - exchange chromatography in the presence of urea , restored promoter - directed initiation activity to pol II delta 4 / 7 .", "entities": [ "pol II holoenzyme", "pol II delta 4 / 7" ] }, { "id": "11086", "type": "gene", "text": "Together , these results suggest that EGF / Ras / Raf induces transcription via combined activation of ATF3 / c - Jun and a 52 - kDa nuclear factor , whereas JunD acts as a repressor of this response .", "entities": [ "EGF", "Ras", "Raf", "ATF3", "c - Jun", "JunD" ] }, { "id": "5225", "type": "gene", "text": "Althoug RBF tended to increase after the therapy , there was no statistically significant change in RBF , GFR and cardiac output .", "entities": [] }, { "id": "1874", "type": "gene", "text": "This repression does not require the PU . 1 transactivation or PEST domains and cannot be reversed by p300 expression .", "entities": [ "PU . 1", "p300" ] }, { "id": "6212", "type": "gene", "text": "There has been similar improvement in treating ampullary and periampullary cancer , gallbladder cancer , or extrahepatic bile duct cancer .", "entities": [] }, { "id": "9960", "type": "gene", "text": "Together , these results identify HPK1 as a new component of TCR signaling .", "entities": [ "HPK1", "TCR" ] }, { "id": "10841", "type": "gene", "text": "Curiously , testololactone was earlier and more widely used than aminoglutethimide in treating advanced breast carcinoma .", "entities": [] }, { "id": "3766", "type": "gene", "text": "Current status of telepathology .", "entities": [] }, { "id": "12546", "type": "gene", "text": "CONCLUSION : These findings imply that eotaxin either is mechanistically involved in acute asthma or serves as a biomarker for activity of the CCR3 receptor ligand system , which is functionally linked to asthma .", "entities": [ "CCR3 receptor ligand" ] }, { "id": "3972", "type": "gene", "text": "Spleen weight in rats during tumour growth and in homograft rejection .", "entities": [] }, { "id": "4031", "type": "gene", "text": "Keck , C . J .", "entities": [] }, { "id": "7051", "type": "gene", "text": "Lesion diameters of greater than 20 mm and the large sessile - type configurations were factors that were associated with incomplete removal .", "entities": [] }, { "id": "6721", "type": "gene", "text": "The results demonstrate that the Glc7 phosphatase and its Gac1 regulatory subunit play positive roles in HSF activation of CUP1 transcription .", "entities": [ "Glc7 phosphatase", "Gac1", "HSF", "CUP1" ] }, { "id": "10238", "type": "gene", "text": "20 % of total HSL transcripts in human subcutaneous adipocytes .", "entities": [ "HSL transcripts" ] }, { "id": "446", "type": "gene", "text": "PLUS - 3 is a new Swedish protocol of natural speech in 3 - year - old children .", "entities": [] }, { "id": "1805", "type": "gene", "text": "A 3 - week regimen of erythropoietin may help prevent the donor ' s need to receive allogeneic blood transfusion , when the initial Hb levels were below 130 milligrams .", "entities": [ "erythropoietin", "Hb" ] }, { "id": "2170", "type": "gene", "text": "Many of the important genes associated with G1 regulation have been shown to play a key role in proliferation , differentiation and oncogenic transformation and programmed cell death ( apoptosis ) .", "entities": [] }, { "id": "690", "type": "gene", "text": "This inhibitory domain has been deleted in all naturally occurring AHC deletion mutants described to date .", "entities": [ "AHC deletion mutants" ] }, { "id": "2469", "type": "gene", "text": "Frog type I ( Ft I ) and frog type II ( Ft II ) slowly adapting ( SA ) units produced spikes only at the indentation phase , and the threshold response phase ( TRP ) , i . e . . the phase of the first spike was for ca .", "entities": [] }, { "id": "7265", "type": "gene", "text": "The optimal sequence for interaction with mu 2 and with AP - 2 has tyrosine as an anchor and prefers arginine at position Y + 2 and leucine at position Y + 3 .", "entities": [ "mu 2", "AP - 2" ] }, { "id": "8087", "type": "gene", "text": "A new physiopathological treatment of HBV - related polyarteritis inspired by advances in the treatment of chronic active hepatitis B was tested in 7 patients .", "entities": [] }, { "id": "11561", "type": "gene", "text": "A rapid staining technique for Leishmania parasites in splenic aspirate smears .", "entities": [] }, { "id": "8076", "type": "gene", "text": "According to the results of assays obtained with the use of assay systems ORTHO ELISA and ABBOTT HCV EIA ( USA ) , the detection rate of anti - HCV - C100 - 3 among primary blood donors in Moscow was 1 . 37 % and was not different from that among HBsAg carriers ( 1 . 8 % ) and among donors with anti - HCV - C100 - 3 in the blood ( 1 . 6 % ) ( p < 0 . 01 ) .", "entities": [ "anti - HCV - C100 - 3", "HBsAg", "anti - HCV - C100 - 3" ] }, { "id": "3254", "type": "gene", "text": "In view of the short t1 / 2 , we used three doses / day .", "entities": [] }, { "id": "4340", "type": "gene", "text": "The fourth dose produced favorable results ( 66 . 7 % ) in individuals with HB antibodies between 10 and 100 IU / ml and unfavorable ones ( 3 . 8 % ) where the HB antibodies were below 10 IU / ml .", "entities": [ "HB antibodies", "HB antibodies" ] }, { "id": "590", "type": "gene", "text": "Five women ( 15 . 6 % ) met criteria for PMS .", "entities": [] }, { "id": "4893", "type": "gene", "text": "This phenomenon may be regarded as a variant of selective individual cell death , currently referred to as apoptosis , which has not been previously reported in a case of embryonal rhabdomyosarcoma .", "entities": [] }, { "id": "2789", "type": "gene", "text": "RESULTS : Looking at the question of its benefits , we were unable to find any methodologically sound studies that have shown efficacy for EMDR in eating disorders , or , indeed , any psychiatric disorder .", "entities": [] }, { "id": "9089", "type": "gene", "text": "The sixth nucleotide was bulged out to allow stacking of this U . G pair on the adjacent helical region .", "entities": [] }, { "id": "10642", "type": "gene", "text": "MK - 801 administration resulted in a biphasic response in seizure latency .", "entities": [] }, { "id": "9657", "type": "gene", "text": "Fluid ( AVLF ) 31 .", "entities": [] }, { "id": "6264", "type": "gene", "text": "If we apply the finding of non - visualization of the GB at 4 h post injection as the criterion for the diagnosis of AC , the diagnostic accuracy was only 40 . 7 % ( 11 / 27 ) .", "entities": [] }, { "id": "10138", "type": "gene", "text": "Appl .", "entities": [] }, { "id": "6356", "type": "gene", "text": "All problems were associated with fractured or lost screws .", "entities": [] }, { "id": "7741", "type": "gene", "text": "The fibrinogen , serum proteins , sodium heparin and membrane contributed to Cm by 20 % , 14 % , 2 % and 64 % , respectively .", "entities": [ "fibrinogen" ] }, { "id": "5333", "type": "gene", "text": "The standard method for calculating the composite score on the S - B IV excludes subtests with a raw score of 0 , which overestimates cognitive functioning in young biologically high risk children .", "entities": [] }, { "id": "8405", "type": "gene", "text": "The structural genes encoding glyceraldehyde - 3 - phosphate dehydrogenase ( GAPDH ) , 3 - phosphoglycerate kinase ( PGK ) and the N - terminal part of triosephosphate isomerase ( TIM ) from mesophilic Bacillus megaterium DSM319 have been cloned as a gene cluster ( gap operon ) by complementation of an Escherichia coli gap amber mutant .", "entities": [ "glyceraldehyde - 3 - phosphate dehydrogenase", "GAPDH", "3 - phosphoglycerate kinase", "PGK", "triosephosphate isomerase", "TIM", "gap operon", "gap amber mutant" ] }, { "id": "8965", "type": "gene", "text": "These results demonstrate a specific association of SIV and HIV - 2 nef , but not HIV - 1 nef , with TCRzeta .", "entities": [ "HIV - 2 nef", "HIV - 1 nef", "TCRzeta" ] }, { "id": "9931", "type": "gene", "text": "Detailed analysis of alpha1 , 3GT transcripts revealed two major alternative splicing patterns in the 5 ' - untranslated region ( 5 ' - UTR ) and evidence for minor splicing activity that occurs in a tissue - specific manner .", "entities": [ "alpha1 , 3GT transcripts" ] }, { "id": "4742", "type": "gene", "text": "The PEBP2 alpha proteins contain a 128 - amino - acid ( aa ) region highly homologous to the Drosophila melanogaster segmentation gene runt .", "entities": [ "PEBP2 alpha proteins", "Drosophila melanogaster segmentation gene runt" ] }, { "id": "3763", "type": "gene", "text": "Theories proffered to account for the modality shift effect are critically evaluated .", "entities": [] }, { "id": "7686", "type": "gene", "text": "One hundred twenty units of deglycerolized red blood cells , some with glycerol added so as to exceed an acceptable 1 % glycerol content , had measurements made of the post - wash supernatant fluid by refractive index and osmometry .", "entities": [] }, { "id": "9008", "type": "gene", "text": "Because of its wide spectrum of activity particularly against ampicillin resistant strains of H . influenzae and because of its good tolerance Cefaclor is very useful in treatment of respiratory tract infections in children .", "entities": [] }, { "id": "1817", "type": "gene", "text": "The weak relationships between F and Zn to Mg clearly have no significant effect on the contents of these elements in bone .", "entities": [] }, { "id": "1924", "type": "gene", "text": "We have examined the role of two recombination - and repair - defective mutations , rad1 and rad52 , on direct repeat recombination in transcriptionally active and inactive sequences .", "entities": [ "rad1", "rad52" ] }, { "id": "9067", "type": "gene", "text": "The proportion of the biopsies found to be seropositive for HBs antigen was 27 . 9 % , and these showed either MGN or MPGN pattern .", "entities": [ "HBs antigen" ] }, { "id": "2515", "type": "gene", "text": "\" Complex partial \" seizures .", "entities": [] }, { "id": "8564", "type": "gene", "text": "Oligodeoxynucleotides antisense to the predicted translation initiation regions of ICP4 and pp38 mRNAs inhibited proliferation of MSB1 cells but not MDCC - CU91 ( CU91 ) reticuloendotheliosis virus - transformed cells .", "entities": [ "ICP4", "pp38 mRNAs" ] }, { "id": "7761", "type": "gene", "text": "Haemodynamic responses to antagonism of bocurarine block with atropine - neostigmine mixture in children .", "entities": [] }, { "id": "7942", "type": "gene", "text": "Antibodies affinity - purified using the bacterially expressed recombinant protein recognized the 56K autoantigen in a HeLa cell extract .", "entities": [ "56K autoantigen" ] }, { "id": "5645", "type": "gene", "text": "This motif , first described for the Drosophila homeobox activator DEAF - 1 , identifies an emerging group of metazoan transcriptional modulators .", "entities": [ "Drosophila homeobox activator DEAF - 1" ] }, { "id": "10929", "type": "gene", "text": "After PTCA , ejection fraction increased from 54 + / - 8 % to 59 + / - 8 % ( p less than 0 . 05 ) and regional function improved significantly ( maximal standard deviation before PTCA : 2 . 8 + / - 0 . 8 ; after PTCA : 1 . 9 + / - 0 . 9 - segments below the first standard deviation before PTCA : 31 + / - 16 ; after PTCA : 19 + / - 17 ) .", "entities": [] }, { "id": "8698", "type": "gene", "text": "The results point to the effectiveness of the educational intervention .", "entities": [] }, { "id": "8887", "type": "gene", "text": "Multiple copies of rsmB + DNA , on the other hand , stimulate exoenzyme production by relieving the negative effects of a chromosomal copy of hexA + .", "entities": [ "rsmB + DNA", "hexA +" ] }, { "id": "9935", "type": "gene", "text": "Its clinical and histopathologic characteristics .", "entities": [] }, { "id": "6740", "type": "gene", "text": "However , despite its relationship to the TR , Rev - Erb bound poorly to TR binding sites .", "entities": [ "TR", "Rev", "Erb", "TR binding sites" ] }, { "id": "6796", "type": "gene", "text": "Some of the mutations obtained do not contain a copy of the Ulysses element at the mutant locus , suggesting that a different transposable element may be responsible for the mutation .", "entities": [ "Ulysses element" ] }, { "id": "6476", "type": "gene", "text": "Because of the probable causal relationship between constitutive p210 ( bcr / abl ) protein tyrosine kinase activity and manifestations of chronic - phase chronic myelogenous leukemia ( CML ; myeloid expansion ) , a key goal is to identify relevant p210 substrates in primary chronic - phase CML hematopoietic progenitor cells .", "entities": [ "p210", "bcr", "abl", "protein tyrosine kinase", "p210" ] }, { "id": "9196", "type": "gene", "text": "Significance of thin glomerular basement membranes in hematuric children .", "entities": [] }, { "id": "6112", "type": "gene", "text": "Neither is it a major cause of rehydration - induced renal Na retention .", "entities": [] }, { "id": "6846", "type": "gene", "text": "Thus , the effects of father absence under routine conditions in relatively healthy samples may exert no significant effects independent of intervening family stressors or maternal psychopathology .", "entities": [] }, { "id": "3837", "type": "gene", "text": "Differential screening of mitochondrial cDNA libraries from male - fertile and cytoplasmic male - sterile sugar - beet reveals genome rearrangements at atp6 and atpA loci .", "entities": [ "atp6", "atpA loci" ] }, { "id": "11976", "type": "gene", "text": "SIT ( SHP2 - interacting transmembrane adaptor protein ) is a recently identified transmembrane adaptor protein , which is expressed in lymphocytes .", "entities": [ "SIT", "SHP2 - interacting transmembrane adaptor protein" ] }, { "id": "4378", "type": "gene", "text": "This study was designed to assess and compare the ability of three different forms of DSG to block EIB .", "entities": [] }, { "id": "11045", "type": "gene", "text": "When the blood clot is formed in the vitreous cavity , intravitreal injection of t - PA can convert plasminogen to plasmin and remove the clot .", "entities": [ "t - PA", "plasminogen", "plasmin" ] }, { "id": "3197", "type": "gene", "text": "The promoter of the rat pgp2 / mdr1b gene has a GC - rich region ( pgp2GC ) that is highly conserved in mdr genes and contains an consensus Sp1 site .", "entities": [ "pgp2", "mdr1b", "pgp2GC", "mdr genes", "Sp1 site" ] }, { "id": "7006", "type": "gene", "text": "The films were analyzed using a scanning helium - neon laser densitometer with a small aperture of 5 - 10 microns .", "entities": [] }, { "id": "682", "type": "gene", "text": "There was also a highly significant correlation between total selenium intake and liver selenium concentration ( r = 0 . 99 , p < 0 . 01 ) after 1 mo of treatment , but this time liver selenium did not change with time , and the correlation remained highly significant throughout the investigation .", "entities": [] }, { "id": "1784", "type": "gene", "text": "To identify some of the genes expressed in LPS - activated coelomocytes , we sequenced randomly chosen clones from a directionally constructed cDNA library to produce a set of expressed sequence tags ( ESTs ) .", "entities": [] }, { "id": "9380", "type": "gene", "text": "Thyroid lymphoma and its management .", "entities": [] }, { "id": "7680", "type": "gene", "text": "DNA sequencing and Southern blot analyses established that the cDNA clones are derived from two different genes .", "entities": [] }, { "id": "12111", "type": "gene", "text": "Therefore the binding sites for liver - enriched factors , present in the hamster CYP7A1 proximal promoter in close vicinity and conserved between species , constitute a regulatory unit important for basal hepatic expression and tissue restriction of the action of hormones such as insulin .", "entities": [ "hamster CYP7A1 proximal promoter", "insulin" ] }, { "id": "4087", "type": "gene", "text": "When two determinations were performed on 12 samples of plasma taken from normal adults in October , the values were 22 . 6 + / - 4 . 8 and 21 . 0 + / - 3 . 6 ( mean + / - SD ) ng / ml , respectively .", "entities": [] }, { "id": "5479", "type": "gene", "text": "However , if EMPD involves the glans penis or perianal area , a search for internal malignancy is still warranted .", "entities": [] }, { "id": "20", "type": "gene", "text": "These activities are all required for stimulation of cell growth by middle - T and activate members of the MAP kinase family .", "entities": [ "middle - T", "MAP kinase family" ] }, { "id": "8791", "type": "gene", "text": "RNAs are not only essential components of both ribosomal subunits but also transiently interacting factors during particle formation .", "entities": [] }, { "id": "6559", "type": "gene", "text": "The financial impact of childhood asthma has not been assessed since Vance and Taylor reported their data in Annals of Allergy 13 years ago .", "entities": [] }, { "id": "2851", "type": "gene", "text": "Antibodies directed against the SNM1 protein immunoprecipitated RNase MRP RNA from whole - cell extracts without precipitating the structurally and functionally related RNase P RNA .", "entities": [ "SNM1 protein", "RNase MRP RNA", "RNase P RNA" ] }, { "id": "10457", "type": "gene", "text": "CONCLUSION : Sonographic angiography has a possible role in the detection of small nodules in patients with CRF .", "entities": [] }, { "id": "3650", "type": "gene", "text": "Immunochemotherapy with schizophyllan ( SPG ) combined with chemotherapeutic agents was evaluated in two syngeneic tumor - C3H / He mouse systems .", "entities": [] }, { "id": "864", "type": "gene", "text": "From our ultrastructural and biochemical studies , it is evident that Type II pneumocytes are an early target of radiation and the release of surfactant into the alveolus shortly after exposure persists for days and weeks .", "entities": [] }, { "id": "8210", "type": "gene", "text": "KRN2391 and cromakalim produced a dose - dependent increase in aortic and coronary blood flow .", "entities": [] }, { "id": "3711", "type": "gene", "text": "The yeast SSS1 gene is essential for secretory protein translocation and encodes a conserved protein of the endoplasmic reticulum .", "entities": [ "yeast SSS1 gene" ] }, { "id": "8854", "type": "gene", "text": "By screening a cDNA library with a probe derived from sequences downstream of the p53p2 start site , we have cloned and characterized a cDNA that represents a mRNA that appears to have been initiated from the p53p2 promoter .", "entities": [ "p53p2", "p53p2 promoter" ] }, { "id": "884", "type": "gene", "text": "The results of supershift analysis using specific antibodies against transcription factors suggested that both binding complexes contained the NF - kappaB components p50 and p65 , and did not contain other NF - kappaB proteins ( p52 , c - Rel , Rel B ) , AP - 1 proteins ( c - Fos , C - Jun ) , CREB or C / EBPbeta ( NF - IL6 ) .", "entities": [ "NF - kappaB", "p50", "p65", "NF - kappaB proteins", "p52", "c - Rel", "Rel B", "AP - 1 proteins", "c - Fos", "C - Jun", "CREB", "C / EBPbeta", "NF - IL6" ] }, { "id": "10334", "type": "gene", "text": "Cell lines derived from the tumors were examined by fluorescent in situ hybridization for the status of the transferred human chromosome and by PCR for marker loss .", "entities": [] }, { "id": "8414", "type": "gene", "text": "Orthop .", "entities": [] }, { "id": "12200", "type": "gene", "text": "9 , 11 - Seco steroids derived from estradiol 3 - methyl ether .", "entities": [] }, { "id": "2909", "type": "gene", "text": "In vitro DNase I footprinting showed that OxyR - C199S protected Pmom from - 104 to - 46 on the top strand and produced a protection pattern characteristic of reduced wild - type OxyR .", "entities": [ "DNase I", "OxyR - C199S", "Pmom", "reduced wild - type OxyR" ] }, { "id": "11181", "type": "gene", "text": "LD50 values of terms of KP were 84 mg / kg in male rats and 122 mg / kg in female rats when KP - CMC was administered intrarectally , and 117 mg / kg in male and 92 mg / kg in female when KP - T10 was administered intrarectally . , while peroral administration of KP - CMC showed LD50 values of 68 mg / kg in males and 78 mg / kg in females in terms of KP .", "entities": [] }, { "id": "11891", "type": "gene", "text": "In contrast , c - Src - derived construct ( a - Src ) , that was excluded from detergent - resistant membranes , could not restore the series of phagocytosis signaling .", "entities": [ "c - Src - derived construct", "a - Src" ] }, { "id": "1005", "type": "gene", "text": "Serial levels of troponin T and the activity of CK - MB were measured 6 , 12 , 24 and 48 h after aortic unclamping .", "entities": [ "troponin T", "CK - MB" ] }, { "id": "4398", "type": "gene", "text": "As a sequence - specific DNA binding transcription factor , p53 specifically binds to a 20 - bp consensus motif 5 ' - PuPuPuC ( A / T ) ( T / A ) GPyPyPyPuPuPuC ( A / T ) ( T / A ) GPyPyPy - 3 ' .", "entities": [ "p53" ] }, { "id": "5052", "type": "gene", "text": "The serine - threonine kinase gene is likely functional , whereas the zinc finger motif is likely nonfunctional .", "entities": [ "serine - threonine kinase gene" ] }, { "id": "4642", "type": "gene", "text": "Statistics for nurse managers - - 3 .", "entities": [] }, { "id": "2833", "type": "gene", "text": "Abstracts .", "entities": [] }, { "id": "3846", "type": "gene", "text": "Mean Hg concentrations in the livers of mice at some sites in Isle Royale are not significantly lower ( P = 0 . 62 ) than Hg concentrations considered by some government agencies to be unhealthy for human consumption .", "entities": [] }, { "id": "11299", "type": "gene", "text": "Results from our and other laboratories have suggested that UCN - 01 induces preferential G1 - phase accumulation in several human tumor cell lines tested .", "entities": [] }, { "id": "11620", "type": "gene", "text": "Cotransfection of either construct with plasmids encoding PKI ( 1 - 31 ) inhibits cAMP - stimulated but not basal - or phorbol ester - stimulated expression .", "entities": [ "PKI ( 1 - 31 )" ] }, { "id": "7165", "type": "gene", "text": "Here we have tested the hypothesis that the short transcripts , or proteins translated from the short transcripts , are also required for respiration .", "entities": [] }, { "id": "6179", "type": "gene", "text": "Unlike p59v - rel , which is a nuclear protein in CEF , indirect immunofluorescence showed that p68c - rel in JD214c - rel infected CEF is located exclusively in the cytoplasm of these cells , even though the sequence of p68c - rel showed that it contains a nuclear localizing sequence identical to the one previously identified in p59v - rel .", "entities": [ "p59v", "rel", "p68c", "rel", "p68c", "rel", "p59v", "rel" ] }, { "id": "9687", "type": "gene", "text": "When mixed with aqueous solutions of TMT - 55 , aqueous solutions of either reagent - grade zinc , cadmium , or lead salts precipitate crystalline \" Zn - TMT \" , amorphous or crystalline \" Cd - TMT \" or amorphous \" Pb - TMT \" ( M3 [ S3C3N3 ] 2 . nH2O , where M = Cd2 + , Pb2 + , and Zn2 + and n > or = 0 ) that may eventually crystallize if stored in air .", "entities": [] }, { "id": "2231", "type": "gene", "text": "Mutations affecting only CD4 regulation mapped to residues previously shown to mediate the binding of Nef to this receptor , such as W57 and L58 , as well as to an AP - recruiting dileucine motif and to an acidic dipeptide in the C - terminal region of the protein .", "entities": [ "CD4", "Nef", "AP - recruiting dileucine motif" ] }, { "id": "664", "type": "gene", "text": "JCAHO revised interpretation", "entities": [] }, { "id": "1488", "type": "gene", "text": "Developmental toxicity of the class III antiarrhythmic agent almokalant in mice .", "entities": [] }, { "id": "7427", "type": "gene", "text": "The C2C - Prx is encoded as a preprotein of 273 amino acids containing a putative chloroplast - targeting signal of 65 amino acids at its N - terminus .", "entities": [ "C2C", "Prx" ] }, { "id": "1529", "type": "gene", "text": "STUDY DESIGN AND METHODS : A study was initiated to compare the collection of PBPCs with the new device , the AutoPBSC ( version [ V ] 6 . 0 with AutoPBSC tubing set ) , and that with the MNC ( mononuclear cell ) procedure ( V4 . 7 with white cell tubing set ) , for patients and healthy donors .", "entities": [] }, { "id": "9779", "type": "gene", "text": "Regulation of ASN1 and ASN2 expression was studied using lacZ fusions and both genes were found to be several times less expressed in the absence of the transcription activator Gcn4p .", "entities": [ "ASN1", "ASN2", "lacZ fusions", "Gcn4p" ] }, { "id": "12047", "type": "gene", "text": "Given its relative longevity on the Web , TIE researchers have been in a unique position to observe trends in telemedicine .", "entities": [] }, { "id": "1300", "type": "gene", "text": "( 5 ) No changes were observed in the gastric venous blood flow by continuous intravenous injection of cimetidine , but by rapid injection both the flow was augmented and the systemic blood pressure decreased transiently .", "entities": [] }, { "id": "1657", "type": "gene", "text": "Transcription of the gene for ivanolysin O and expression of other genes of the virulence gene cluster in L . ivanovii were dependent on PrfA .", "entities": [ "ivanolysin O", "virulence gene cluster in L . ivanovii", "PrfA" ] }, { "id": "8781", "type": "gene", "text": "The data further indicate that the IL - 7R alpha chains are directly involved in the activation of JAKs and STATs and have a major role in proliferative signaling in precursor B cells .", "entities": [ "IL - 7R alpha chains", "JAKs", "STATs" ] }, { "id": "2064", "type": "gene", "text": "We conclude from these studies that CKII may act as a positive regulator of myogenesis by preventing E protein homodimers from binding to muscle gene regulatory elements .", "entities": [ "CKII", "E protein homodimers" ] }, { "id": "8175", "type": "gene", "text": "Temporal control of GUS expression was found to involve two negative regulatory sequences , NRS1 ( - 391 to - 295 ) and NRS2 ( - 518 to - 418 ) , as well as the positive domain UAS1 .", "entities": [ "GUS" ] }, { "id": "8808", "type": "gene", "text": "Chemical uptake into human stratum corneum in vivo from volatile and non - volatile solvents .", "entities": [] }, { "id": "786", "type": "gene", "text": "RESULTS : We identified a full - length cDNA with an open reading frame of 2883 bp corresponding to a predicted protein of 961 amino acids that shares greater than 95 % homology with the rat gamma - aminobutyric acid B ( GABAB ) receptor .", "entities": [ "rat gamma - aminobutyric acid B ( GABAB ) receptor" ] }, { "id": "6463", "type": "gene", "text": "The region containing both serines is homologous to the N - terminal destruction box of IkappaBalpha , - beta , and - epsilon .", "entities": [ "IkappaBalpha , - beta , and - epsilon" ] }, { "id": "5902", "type": "gene", "text": "To identify these sites , Cdk2 - phosphorylated MARCKS was digested with lysyl endoprotease and analysed by electrospray MS .", "entities": [ "Cdk2", "MARCKS", "lysyl endoprotease" ] }, { "id": "7440", "type": "gene", "text": "Four patients ( group 1 ) had type I basement membrane nephropathy , characterized by marked thickening and lamellation of the basement membrane in a pattern resembling that of Alport ' s syndrome .", "entities": [] }, { "id": "3195", "type": "gene", "text": "Although ANP induced systemic capillary filtration , in the calf , filtration was reduced with ANP .", "entities": [ "ANP", "ANP" ] }, { "id": "9407", "type": "gene", "text": "Recent work in this laboratory has shown that the gene coding for acetate kinase ( ackA ) in Sinorhizobium meliloti is up - regulated in response to phosphate limitation .", "entities": [ "acetate kinase", "ackA" ] }, { "id": "3017", "type": "gene", "text": "Based on these results the minimal control element ( AX 470 ) specifying the anterior boundary of Hox expression was designated as Hoxa - 7 enhancer .", "entities": [ "Hox", "Hoxa - 7 enhancer" ] }, { "id": "736", "type": "gene", "text": "Heterogeneous nuclear ribonucleoprotein ( hnRNP ) core protein A1 is a major component of mammalian hnRNP 40 S particles .", "entities": [ "Heterogeneous nuclear ribonucleoprotein ( hnRNP ) core protein A1", "mammalian hnRNP 40 S particles" ] }, { "id": "1890", "type": "gene", "text": "Purified Hsk1 phosphorylates the Cdc19 ( Mcm2 ) subunit of the six - member minichromosome maintenance protein complex purified from fission yeast .", "entities": [ "Hsk1", "Cdc19", "Mcm2", "six - member minichromosome maintenance protein complex" ] }, { "id": "11516", "type": "gene", "text": "Discordance on the cost dimension correlated negatively with G Hb , suggesting better glycemic control with greater disagreement .", "entities": [ "G Hb" ] }, { "id": "7862", "type": "gene", "text": "Analysis of proteins synthesized by plasmids containing deleted forms of the trfA region indicates that the A2 protein is the essential trfA - encoded replication protein of plasmid RK2 .", "entities": [ "trfA region", "A2 protein", "trfA - encoded replication protein" ] }, { "id": "9203", "type": "gene", "text": "A probe evoked potentials procedure was used to assess the relative engagement of both cerebral hemispheres during a language task in the following four groups of dextral adults : left hemisphere ( LH ) - damaged aphasics recovering from stroke , dysarthrics , right hemisphere ( RH ) - damaged nonaphasic patients , and normal control subjects .", "entities": [] }, { "id": "2646", "type": "gene", "text": "The results show that the structure of the decorin gene promoter is different from that of any other proteoglycan promoter characterized so far and indicate that the pur / pyr segment plays a role in the regulation of gene transcription .", "entities": [ "decorin gene promoter" ] }, { "id": "10454", "type": "gene", "text": "Integrated mapping analysis of the Werner syndrome region of chromosome 8 .", "entities": [] }, { "id": "213", "type": "gene", "text": "DMI and 2 - OH - DMI concentrations were determined in a similar group of 61 DMI - treated patients .", "entities": [] }, { "id": "12099", "type": "gene", "text": "Mature and old B6AF1 and B6D2F1 mice were given acidified tap water or promethazine HCl ( a phenothiazine with H1 receptor blocking activity ) , chlorpheniramine ( an H1 blocker ) or trifluoperazine ( a phenothiazine with no H1 blocking activity ) in their drinking water , and the effects of these agents on bone mineral content were assessed by intermittently measuring the 24 - h whole body retention of Tc 99m methylene diphosphonate ( Tc 99m MDP , an indicator of bone metabolism ) and at the end of the studies by determining ash weights of femur , ilium and sacrum .", "entities": [ "H1 receptor", "H1", "H1" ] }, { "id": "2656", "type": "gene", "text": "Structure , promoter analysis and chromosomal assignment of the human APEX gene .", "entities": [ "human APEX gene" ] }, { "id": "11396", "type": "gene", "text": "The results were as follows : 1 ) Total integrated EMG activity of FB group was approximately equal in any occluded position , whereas that of CG and GF group varied from position to position .", "entities": [] }, { "id": "6889", "type": "gene", "text": "No TATA or Inr sequence was found .", "entities": [] }, { "id": "6111", "type": "gene", "text": "The RNA aptamer contains three stems separated by a pair of two - base bulges , and adopts an unanticipated fold in which both junctional sites are anchored through base triple formation .", "entities": [] }, { "id": "4674", "type": "gene", "text": "This conclusion is based on the observations of the immunologic changes that characterize the acute stages of illness as well as on the demonstrated association with toxin - producing bacteria in the pharynx and gastrointestinal tract .", "entities": [] }, { "id": "2283", "type": "gene", "text": "Copyright 2001 Academic Press .", "entities": [] }, { "id": "477", "type": "gene", "text": "Subcloning of DNA fragments from the 8 . 5 - kilobase ( kb ) insert of pAVO4 defined a 4 - kb DNA fragment which contained the functional FBP + gene and its regulatory region .", "entities": [ "functional FBP + gene" ] }, { "id": "4555", "type": "gene", "text": "Ras2p activates invasive growth using either of two downstream signaling pathways , the filamentation MAPK ( Cdc42p / Ste20p / MAPK ) cascade or the cAMP - dependent protein kinase ( Cyr1p / cAMP / PKA ) pathway .", "entities": [ "Ras2p", "MAPK", "Cdc42p", "Ste20p", "MAPK", "cAMP - dependent protein kinase", "Cyr1p", "PKA" ] }, { "id": "8098", "type": "gene", "text": "According to their functional properties the latter neurons were subdivided into : ( a ) neurons responding to stimuli near the eyes ; ( b ) neurons triggered by complex visual stimuli ; ( c ) neurons inhibited by visual stimuli .", "entities": [] }, { "id": "1697", "type": "gene", "text": "We have identified two Marek ' s Disease Virus ( MDV ) genes within the EcoRI - B fragment of MDV - GA genomic DNA .", "entities": [ "EcoRI - B fragment" ] }, { "id": "8775", "type": "gene", "text": "The binding specificity of this protein was compared to that of human E2F using a number of mutant E2F sites as competitors .", "entities": [ "human E2F", "mutant E2F sites" ] }, { "id": "6427", "type": "gene", "text": "BCL6 encodes a POZ / Zn finger protein , a structure similar to that of many Drosophila developmental regulators and to another protein involved in a human hematopoietic malignancy , PLZF .", "entities": [ "BCL6", "POZ / Zn finger protein", "PLZF" ] }, { "id": "6433", "type": "gene", "text": "Sci .", "entities": [] }, { "id": "5738", "type": "gene", "text": "The data imply that JAK / STAT signaling has a role in EBV - associated malignancies .", "entities": [ "JAK", "STAT" ] }, { "id": "1284", "type": "gene", "text": "This family of proteins binds GC - rich motifs widely distributed in gene promoters , resulting in distinct activation or repression of transcriptional activities .", "entities": [] }, { "id": "11235", "type": "gene", "text": "PSI - G and PSI - K probably have evolved from a gene duplication of an ancestral gene .", "entities": [ "PSI - G", "PSI - K" ] }, { "id": "12551", "type": "gene", "text": "The opioid antagonist naltrexone ( 0 . 01 - 1 . 0 mg / kg ) antagonized the discriminative stimulus effects of heroin , but naltrexone at doses up to 10 mg / kg had no effect on the discriminative stimulus effects of cocaine .", "entities": [] }, { "id": "3142", "type": "gene", "text": "We have inactivated Krox - 20 by homologous recombination in ES cells and demonstrated that the mutation leads to the deletion of r3 and r5 .", "entities": [ "Krox - 20" ] }, { "id": "1568", "type": "gene", "text": "Judge OKs docs ' bid for Chicago hospital .", "entities": [] }, { "id": "11893", "type": "gene", "text": "The repetitive ETn ( early transposon ) family of sequences represents an active \" mobile mutagen \" in the mouse genome .", "entities": [ "ETn", "early transposon" ] }, { "id": "0", "type": "gene", "text": "Immunohistochemical staining was positive for S - 100 in all 9 cases stained , positive for HMB - 45 in 9 ( 90 % ) of 10 , and negative for cytokeratin in all 9 cases in which myxoid melanoma remained in the block after previous sections .", "entities": [ "S - 100", "HMB - 45", "cytokeratin" ] }, { "id": "12254", "type": "gene", "text": "METHODS : DSF was instilled in one eye chosen at random and CF in the fellow eye of 13 normal subjects and in 13 patients with KCS .", "entities": [] }, { "id": "5627", "type": "gene", "text": "COUP transcription factor is a member of the steroid receptor superfamily .", "entities": [ "COUP transcription factor", "steroid receptor superfamily" ] }, { "id": "2899", "type": "gene", "text": "Microcomputer management of chronic hepatitis B virus asymptomatic patients", "entities": [] }, { "id": "5421", "type": "gene", "text": "BACKGROUND : Hepatic encephalopathy is a neuropsychiatric syndrome associated with acute liver failure , chronic parenchymal liver disease or portal systemic anastomosis .", "entities": [] }, { "id": "7756", "type": "gene", "text": "Critique of \" Interactive Effects of Test Anxiety and Credit / No Credit or A - F Grade Condition upon Short - term and Long - term Recall of Course Information .", "entities": [] }, { "id": "9669", "type": "gene", "text": "In addition , the hGCSFR gene was chromosomally localized by Southern blot analysis of its segregation pattern in a panel of rodent - human hybrid DNAs using the radiolabeled cDNA probe .", "entities": [ "hGCSFR gene" ] }, { "id": "6801", "type": "gene", "text": "However , while IL - 1beta and TNF - alpha both induced nuclear binding of the Rel proteins p50 and p65 to an NF - kappaB consensus oligonucleotide in gel shift assays and caused transient degradation of inhibitor of NF - kappaB - alpha ( IkappaB - alpha ) in the cytoplasm of myofibroblasts , only IL - 1beta upregulated PDGF - Ralpha .", "entities": [ "IL - 1beta", "TNF - alpha", "p50", "p65", "NF - kappaB consensus oligonucleotide", "inhibitor of NF - kappaB - alpha", "IkappaB - alpha", "IL - 1beta", "PDGF - Ralpha" ] }, { "id": "7148", "type": "gene", "text": "Eleven biopsy specimens ( five papules and six dusky or crusted lesions ) from four patients with pityriasis lichenoides et varioliformis acuta ( PLEVA ) were studied by direct immunofluorescence and immunoperoxidase technics .", "entities": [ "immunoperoxidase" ] }, { "id": "3901", "type": "gene", "text": "GATA - 1 mRNA was present in equivalent levels in both erythroid cell lines , but at a low level in FDC - P1 cells .", "entities": [ "GATA - 1 mRNA" ] }, { "id": "8323", "type": "gene", "text": "In 1990 , an International Commission for the Certification of Eradication of Poliomyelitis Eradication ( ICCPE ) was established by the Pan American Health Organization to eventually determine if transmission was interrupted .", "entities": [] }, { "id": "4522", "type": "gene", "text": "However , patients with isolated office hypertension had fewer previous cardiovascular complications .", "entities": [] }, { "id": "278", "type": "gene", "text": "MCh infusion caused a concentration - dependent increase in airway resistance at constant QBA .", "entities": [] }, { "id": "8680", "type": "gene", "text": "A brief discussion of color deficiencies .", "entities": [] }, { "id": "471", "type": "gene", "text": "We suggest that FlgN and FliT are substrate - specific flagellar chaperones that prevent oligomerization of the HAPs by binding to their helical domains before export .", "entities": [ "FlgN", "FliT", "HAPs" ] }, { "id": "9014", "type": "gene", "text": "A 13 base - pair oligonucleotide spanning nucleotides + 80 to + 92 of the 5 S RNA gene retained specific and high - affinity binding , although the latter was reduced sixfold relative to longer DNA fragments .", "entities": [ "5 S RNA gene" ] }, { "id": "4523", "type": "gene", "text": "In the treatment of opioid naive patients who underwent surgery and received opioids for acute pain , oral ADL 8 - 2698 ( 6 . 0 mg ) improved the management of postoperative ileus ( POI ) by shortening the time to achieve normal bowel function and , ultimately , hospital stay .", "entities": [] }, { "id": "1285", "type": "gene", "text": "Serum IgM and IgE concentrations , allergen - specific IgE scores , and the tumor E2R status were combined to construct a three - level risk classification that was more prognostic than any of the individual components .", "entities": [ "Serum IgM", "IgE", "allergen - specific IgE", "E2R" ] }, { "id": "5739", "type": "gene", "text": "The high degree of sequence identity ( 96 % ) between hydrolase B and C , particularly in the 3 ' untranslated region , suggests that the genes encoding these two carboxylesterases evolved by duplication and divergence of a common ancestral gene .", "entities": [ "hydrolase B and C", "carboxylesterases" ] }, { "id": "8772", "type": "gene", "text": "The technique of the TEE visualization of the proximal coronary arteries is described .", "entities": [] }, { "id": "7227", "type": "gene", "text": "The prominent lesions were confined to the cerebral surface layer and leptomeningeal tissue including the arachnoid vessels , which were all bathed in the cerebrospinal fluid , suggesting that some necrotizing toxins had been secreted into the fluid by the B . cereus .", "entities": [] }, { "id": "2331", "type": "gene", "text": "TPTA produced brain congestion , and hepatic and pulmonary petechial and generalized hemorrhages .", "entities": [] }, { "id": "7099", "type": "gene", "text": "In addition , we identified a novel type of inhibitory domain in the N - terminal 60 amino acids of IRF - 1 which strongly inhibits its transcriptional activity .", "entities": [ "IRF - 1" ] }, { "id": "1869", "type": "gene", "text": "Expression of activated Cdc42 results in the translocation of PKClambda from the nucleus into the cytosol , and Cdc42 and PKClambda colocalize at the plasma membrane and in the cytoplasm .", "entities": [ "Cdc42", "PKClambda", "Cdc42", "PKClambda" ] }, { "id": "5244", "type": "gene", "text": "The double - stranded RNA binding domain ( dsRBD ) is an approximately 65 amino acid motif that is found in a variety of proteins that interact with double - stranded ( ds ) RNA , such as Escherichia coli RNase III and the dsRNA - dependent kinase , PKR .", "entities": [ "RNase III", "dsRNA - dependent kinase", "PKR" ] }, { "id": "1225", "type": "gene", "text": "The single site of glycosylation is located near the C - terminus in the N - glycosylation sequon - Asn - Cys - Ser - in which Cys forms part of a disulphide bridge .", "entities": [] }, { "id": "11322", "type": "gene", "text": "Jerseys had higher hepatic Cu concentrations than did Holsteins on d 60 ( 346 vs .", "entities": [] }, { "id": "5221", "type": "gene", "text": "Change in plasma cystyl aminopeptidase ( oxytocinase ) between 30 - 34 weeks ' gestation as a predictor of pregnancy - induced hypertension .", "entities": [ "plasma cystyl aminopeptidase", "oxytocinase" ] }, { "id": "2397", "type": "gene", "text": "Using the yeast one - hybrid screen with integrated NRE and flanking DNA as bait , the predominant clone obtained was bovine Nrl .", "entities": [ "bovine Nrl" ] }, { "id": "4049", "type": "gene", "text": "The microdensitometric scores and their side - to - side differences in patients correlated negatively with the serum 25 - OHD concentration and positively with the degree of paralysis .", "entities": [] }, { "id": "4931", "type": "gene", "text": "DNA - STAT complexes were detected in all Bcr / Abl - transformed cell lines and they were supershifted by antibodies against STAT1 and STAT5 .", "entities": [ "DNA - STAT complexes", "Bcr", "Abl", "STAT1", "STAT5" ] }, { "id": "3217", "type": "gene", "text": "However , although deletion of Fp1 in the hCRBP1 gene yielded increased CAT activity , pointing toward a negative regulatory function exerted by this element , its insertion upstream of the p12 basal promoter results in an impressive positive stimulation of CAT gene expression .", "entities": [ "Fp1", "hCRBP1 gene", "CAT", "p12 basal promoter", "CAT gene" ] }, { "id": "1426", "type": "gene", "text": "We show that a protein , UBC9 , interacts specifically with TEL in vitro and in vivo .", "entities": [ "UBC9", "TEL" ] }, { "id": "766", "type": "gene", "text": "Of these patients , 46 , 164 were placed on a waiting list for transplantation , 23 , 275 of whom received a first cadaveric transplant between 1991 and 1997 .", "entities": [] }, { "id": "9274", "type": "gene", "text": "A medical - geographical review", "entities": [] }, { "id": "6766", "type": "gene", "text": "Mutation of the NF - kappaB site in the Mdr1b promoter prevents its induction by TNF - alpha .", "entities": [ "NF - kappaB site", "Mdr1b promoter", "TNF - alpha" ] }, { "id": "2003", "type": "gene", "text": "The 10 kDa polypeptide was phosphorylated in vitro by incubating wheat etioplast membranes with [ gamma 32P ] ATP .", "entities": [] }, { "id": "2384", "type": "gene", "text": "The 96 - bp insert contained a termination signal which caused the premature termination of the protein , leading to the generation of a p53 product 9 amino acids shorter than usual .", "entities": [ "p53 product" ] }, { "id": "2755", "type": "gene", "text": "The relationships among four descriptors of lactate increase : lactate threshold ( LT ) ( the VO2 at which blood lactate concentration begins to increase above the resting level during an incremental exercise test ) , LT1 ( the VO2 at which blood lactate increases 1 mM above the resting level ) , LT2 ( the VO2 at which blood lactate concentration reaches a fixed value of 2 mM ) , onset of blood lactate accumulation ( OBLA ; the VO2 at which blood lactate reaches a concentration of 4 mM ) , were compared with aerobic capacity ( VO2max ) and 12 min running performance in 19 untrained female students .", "entities": [] }, { "id": "11694", "type": "gene", "text": "A decrease of the lysozyme activity coincided with the clinical improvement of the bacterial meningitis .", "entities": [ "lysozyme" ] }, { "id": "10420", "type": "gene", "text": "The amino acid sequence of the S . aureus peptide carrying the phosphoryl group was found to be Gln - Val - Val - Ser - Thr - Phe - Met - Gly - Asn - Gly - Leu - Ala - Ile - Pro - His - Gly - Thr - Asp - Asp .", "entities": [] }, { "id": "4335", "type": "gene", "text": "The distribution of red rice cultivation in Sri Lanka is coincident with the HIDD villages .", "entities": [] }, { "id": "11079", "type": "gene", "text": "The harpin - encoding hrpZ gene is located in an operon that also encodes Hrp secretion pathway components and is part of the functional cluster of hrp genes carried on cosmid pHIR11 that enables saprophytic bacteria like Escherichia coli and Pseudomonas fluorescens to elicit the HR in tobacco leaves .", "entities": [ "harpin", "hrpZ gene", "Hrp secretion pathway components", "hrp genes" ] }, { "id": "9482", "type": "gene", "text": "Of 270 patients with well - defined drug reactions , 190 ( 70 per cent ) gave a positive response to the mast cell test .", "entities": [] }, { "id": "2118", "type": "gene", "text": "Lens aldose reductase in diabetic and galactosemic cataracts .", "entities": [ "Lens aldose reductase" ] }, { "id": "11040", "type": "gene", "text": "Expression plasmids harboring full - length or kinase domain of PKC alpha and PKC delta ( PKC alpha K and PKC delta K ) were constructed .", "entities": [ "PKC alpha", "PKC delta", "PKC alpha K", "PKC delta K" ] }, { "id": "9370", "type": "gene", "text": "Immediate - early transcription from the channel catfish virus genome : characterization of two immediate - early transcripts .", "entities": [ "immediate - early transcripts" ] }, { "id": "8083", "type": "gene", "text": "Although linker regions in transcription factors are known to modulate DNA binding specificity , our studies suggest that the human HSF1 linker plays no role in determining HSF1 binding preferences in vivo but is a critical determinant in regulating the HSF1 monomer - trimer equilibrium .", "entities": [ "human HSF1", "HSF1", "HSF1 monomer - trimer" ] }, { "id": "5818", "type": "gene", "text": "Further , mutational analysis of NS5A assigned the SH3 - binding region to a proline - rich motif that is highly conserved among HCV genotypes .", "entities": [ "NS5A", "SH3 - binding region" ] }, { "id": "354", "type": "gene", "text": "We report here the isolation of a full - length cDNA clone coding for a hitherto undiscovered isoform of the bovine C - subunit .", "entities": [ "bovine C - subunit" ] }, { "id": "3696", "type": "gene", "text": "The DHEAS levels in all stages of decreased BMD were significantly lower than those in the group with normal BMD .", "entities": [] }, { "id": "12218", "type": "gene", "text": "In addition , a comparison of the hCHLR gene sequences with available databases indicates that a large portion of these genes , including exons encoding two functional domains of the carboxyl - terminal region of these proteins , has been duplicated as part of a larger human telomeric repeat sequence found on many human chromosomes .", "entities": [ "hCHLR gene sequences" ] }, { "id": "4377", "type": "gene", "text": "METHODS : Experiments testing the new catheter and comparing it to the existing catheter included : ( 1 ) measurement of the laser output beam sizes and divergences ; ( 2 ) evaluation of particulate matter generation during ablation of atherosclerotic tissue ; ( 3 ) measurement of ablation hole sizes and tissue penetration rates ; ( 4 ) histopathologic examination of laser - induced in vivo vessel wall injury .", "entities": [] }, { "id": "1191", "type": "gene", "text": "Furthermore , no transcripts of the same size and having the same developmental profile as those generated by the wild - type E10 fragment were identified by probes covering the remainder of the cloned region .", "entities": [ "wild - type E10 fragment" ] }, { "id": "11699", "type": "gene", "text": "Double - blind randomised trial of intravenous tissue - type plasminogen activator versus placebo in acute myocardial infarction .", "entities": [ "tissue - type plasminogen activator" ] }, { "id": "3115", "type": "gene", "text": "Analysis of viral mutants in vivo demonstrated that the NFIII / OCT - 1 binding site and a conserved ATF motif were important for efficient viral growth .", "entities": [ "NFIII", "OCT - 1", "ATF motif" ] }, { "id": "7523", "type": "gene", "text": "Two alternatively spliced 5 ' UTRs , designated type I and type II , of 222 and 115 bp , respectively , were found associated with PFP .", "entities": [ "PFP" ] }, { "id": "2732", "type": "gene", "text": "An expression library was constructed by inserting 5 ' portion - enriched cDNAs from phytohemagglutinin - stimulated peripheral blood mononuclear cells into upstream of signal sequence - deleted CD4 cDNA in an Epstein - Barr virus shuttle vector .", "entities": [ "phytohemagglutinin", "signal sequence - deleted CD4 cDNA" ] }, { "id": "8364", "type": "gene", "text": "The mass - specific resting minute ventilation ( E ) and the ventilatory equivalent ( VE / ( O ( 2 ) ) ) were approximately the same at the two ages , with a breathing pattern significantly deeper and slower at day 1 .", "entities": [] }, { "id": "12069", "type": "gene", "text": "Upstream of the dra gene an open reading frame of 313 amino acids was identified .", "entities": [ "dra gene" ] }, { "id": "1661", "type": "gene", "text": "The minimum inhibitory concentrations ( MICs ) of ketoconazole , miconazole , itraconazole , fluconazole , and amphotericin B were significantly influenced by the inoculum size , regardless of the techniques used .", "entities": [] }, { "id": "12097", "type": "gene", "text": "The intron 8 enhancer region was not activated by GATA - 1 together with Sp1 in transactivation experiments in COS - 1 cells indicating the involvement of a related Sp1 protein or of another unidentified erythroid factor .", "entities": [ "GATA - 1", "Sp1", "Sp1 protein" ] }, { "id": "1680", "type": "gene", "text": "Relapse of leukemia after prolonged remission .", "entities": [] }, { "id": "1907", "type": "gene", "text": "The transmembrane topology of Na ( + ) / H ( + ) exchanger NHE3 has been studied using in vitro transcription / translation of two types of fusion vectors designed to test membrane insertion properties of cDNA sequences encoding putative NHE3 membrane spanning domains ( msds ) .", "entities": [ "NHE3", "NHE3" ] }, { "id": "8047", "type": "gene", "text": "Disorders of platelet function in chronic myeloid leukemias", "entities": [] }, { "id": "3726", "type": "gene", "text": "Specifically , by the type of adjuvant therapy , the median disease - free interval and survival from stage IVA for 23 patients receiving Corynebacterium parvum were 6 . 9 and 19 months ; for 39 patients receiving BCG , eight months and 26 months ; for 24 patients receiving BCG + DTIC , eight and 17 . 4 months ; and for all 51 DTIC treated patients 6 . 3 and 17 . 8 months , respectively .", "entities": [] }, { "id": "9084", "type": "gene", "text": "In the TLE patients the NAA : Cr ratios were reduced in the seizure focus , while in the FLE patients they were not always reduced in the seizure focus .", "entities": [] }, { "id": "4858", "type": "gene", "text": "Thus , NART - R performance may not be a valid estimate of baseline IQ for patients with neurologic disorders with suspected language impairment .", "entities": [] }, { "id": "6441", "type": "gene", "text": "After 10 months of treatment with the conjugated estrogen , both his height and weight showed improvement , while his bone mineral density and bone age were increased .", "entities": [] }, { "id": "11771", "type": "gene", "text": "As authorized by the World Health Organization 29th Expert Committee on Biological Standardization , the preparation of human prolactin in ampoules coded 75 / 504 has been established as the International Reference Preparation ( IRP ) of human prolactin for immunoassay .", "entities": [ "human prolactin", "human prolactin" ] }, { "id": "3279", "type": "gene", "text": "Investigated the reliability , validity and dimensionality of scores obtained by acute psychiatric inpatients ( N = 120 ) on the Michigan Alcoholism Screening Test adapted to assess lifetime and current symptomatology .", "entities": [] }, { "id": "2653", "type": "gene", "text": "Significantly , pPKR is capable of specifically phosphorylating Ser51 in a synthetic eIF - 2alpha peptide , a key characteristic of the eIF - 2alpha kinase family .", "entities": [ "pPKR", "synthetic eIF - 2alpha peptide", "eIF - 2alpha kinase family" ] }, { "id": "3866", "type": "gene", "text": "On the basis of S1 nuclease protection analysis of RNA preparations from several mouse tissues , both dhfr and divergent genes showed similar levels of expression but did show some specificity in start site utilization .", "entities": [ "S1 nuclease", "dhfr" ] }, { "id": "10438", "type": "gene", "text": "Identification of an enhancer and an alternative promoter in the first intron of the alpha - fetoprotein gene .", "entities": [ "alpha - fetoprotein gene" ] }, { "id": "6183", "type": "gene", "text": "The origins of reflected light changes associated with neuronal activity ( optical signals ) were investigated in rat somatosensory cortex with optical imaging , microspectrophotometry , and laser - Doppler flowmetry , and dynamic changes in local hemoglobin concentration and oxygenation were focused on .", "entities": [ "hemoglobin" ] }, { "id": "2100", "type": "gene", "text": "Krox - 24 is therefore a sequence - specific transcriptional activator .", "entities": [ "Krox - 24" ] }, { "id": "2793", "type": "gene", "text": "Fifty - one patients with primary refractory or relapsed malignant lymphoma ( 47 non - Hodgkin ' s lymphoma and four Hodgkin ' s disease ) were treated with a new chemotherapeutic regimen ( cisplatinum , methyl GAG , bleomocyin , methyl prednisolon ) .", "entities": [] }, { "id": "9543", "type": "gene", "text": "The effects of loading the respiratory pumps on the oxygen consumption of Callionymus lyra .", "entities": [] }, { "id": "5975", "type": "gene", "text": "This paper describes the advantages and limitations of the main study approaches used .", "entities": [] }, { "id": "8321", "type": "gene", "text": "Finally , we compared the differential screening techniques in terms of sensitivity , efficiency and occurrence of false positives .", "entities": [] }, { "id": "7752", "type": "gene", "text": "RESULTS : Auditory thresholds collected during audiometric tests increased gradually in proportion with age , especially in the hypertensive group ( p < 0 . 05 ) .", "entities": [] }, { "id": "6173", "type": "gene", "text": "Notably , SRF has been found to be a key regulator of members of a class of cellular response genes termed immediate - early genes ( IEGs ) , many of which are believed to be involved in regulating cell growth and differentiation .", "entities": [ "SRF", "immediate - early genes", "IEGs" ] }, { "id": "896", "type": "gene", "text": "Finally , we demonstrate that C / EBP alpha can also active the GM - CSF receptor alpha promoter in nonmyeloid cells .", "entities": [ "C / EBP alpha", "GM - CSF receptor alpha" ] }, { "id": "6596", "type": "gene", "text": "The fragments are separated and directly sized by agarose gel electrophoresis .", "entities": [] }, { "id": "11552", "type": "gene", "text": "The P131 ORF is followed in - frame by a second ORF which is probably expressed by partial readthrough of the UGA termination codon of the P131 ORF to produce a polypeptide of M ( r ) 191044 ( P191 ) .", "entities": [] }, { "id": "4614", "type": "gene", "text": "In support of clinical antianginal studies , the vasodilator nicorandil ( NIC ) was combined with the beta - adrenergic receptor antagonists propranolol ( PRO ) and atenolol ( ATN ) and with the calcium channel blocker diltiazem ( DTZ ) to determine their cardiovascular and pharmacokinetic interactions .", "entities": [ "beta - adrenergic receptor" ] }, { "id": "1205", "type": "gene", "text": "The spontaneous mutation blocking pca gene expression was located in the promoter for the pca operon .", "entities": [ "pca gene", "pca operon" ] }, { "id": "6240", "type": "gene", "text": "Thus , the presence of the Cln2 PEST domain was sufficient to destabilize a heterologous protein .", "entities": [ "Cln2 PEST domain" ] }, { "id": "8952", "type": "gene", "text": "All injections of CSF were given after the initiation of neutropenia and continued until the occurrence of an absolute neutrophil recovery .", "entities": [ "CSF" ] }, { "id": "5113", "type": "gene", "text": "Using a degenerate oligodeoxyribonucleotide ( oligo ) based on the N - terminal aa sequence , plus an internal oligo homologous to a conserved region within the portion of CYP1 and CYP2 that had been deleted in the genome , a CYP3 - specific DNA fragment was generated by the polymerase chain reaction ( PCR ) using GL81 genomic DNA as a substrate .", "entities": [ "CYP1", "CYP2", "CYP3 - specific DNA fragment" ] }, { "id": "4030", "type": "gene", "text": "CONCLUSION : Our findings suggest that endometriosis increases soluble CD23 levels , which can be suppressed with either danazol or leuprolide acetate injection .", "entities": [ "CD23" ] }, { "id": "1730", "type": "gene", "text": "Sulfuric acid concentration in the catalyzed breathalyzer ampules .", "entities": [] }, { "id": "2428", "type": "gene", "text": "O2 and CO2 in the tracheostomy tube were continuously monitored by mass spectrometry using a special sample - hold phase - locked sampling technique .", "entities": [] }, { "id": "7203", "type": "gene", "text": "We critically assess current systematic uncertainties and determine the primordial Li abundance within new , much tighter limits : & amp ; parl0 ; Li & amp ; solm0 ; H & amp ; parr0 ; p = 1 . 23 + 0 . 68 - 0 . 32x10 - 10 .", "entities": [] }, { "id": "6946", "type": "gene", "text": "We also reported the identification of three corresponding alternative first exons and an intronic promoter in the human PDE5A gene .", "entities": [ "human PDE5A gene" ] }, { "id": "5622", "type": "gene", "text": "Furthermore , a pTyr317 Shc phosphopeptide selectively recognized Grb2 , Sos1 , SHIP , and the p85 subunit of phosphatidylinositol 3 ' kinase from mast cells , as characterized by mass spectrometry .", "entities": [ "pTyr317 Shc phosphopeptide", "Grb2", "Sos1", "SHIP", "p85 subunit", "phosphatidylinositol 3 ' kinase" ] }, { "id": "7172", "type": "gene", "text": "Epithelial cytotoxicity of combined antibiotics was additive , with no evidence of competition or synergism .", "entities": [] }, { "id": "11119", "type": "gene", "text": "Her serum FT3 concentration was , however , much higher than the ranges in normal pregnancy or in GTD patients without clinical hyperthyroidism .", "entities": [] }, { "id": "3255", "type": "gene", "text": "The mechanism of action is explored in some detail , specifically as it relates to reticuloendothelial system ( RES ) Fc receptor blockade and suppression of antiplatelet antibody synthesis .", "entities": [ "Fc receptor" ] }, { "id": "3161", "type": "gene", "text": "Male Japanese quail were chronically exposed to 5000 ppm manganese ( Mn ) as particulate manganese oxide ( Mn3O4 ) in their diet from hatching to 75 days of age .", "entities": [] }, { "id": "2196", "type": "gene", "text": "This complex interacts at the GTPase domain in the large subunit rRNA , overlapping the binding site of the protein L11 - like eukaryotic counterpart ( Saccharomyces cerevisiae protein L15 and mammalian protein L12 ) .", "entities": [ "GTPase domain", "protein L11 - like eukaryotic counterpart", "Saccharomyces cerevisiae protein L15", "mammalian protein L12" ] }, { "id": "387", "type": "gene", "text": "Additionally , the mouse promoter contains 22 copies of a CT dinucleotide repeat sequence located approximately 155 bp 5 ' to exon 1 .", "entities": [] }, { "id": "6236", "type": "gene", "text": "Serum IgE levels in Tauranga children .", "entities": [ "Serum IgE" ] }, { "id": "11880", "type": "gene", "text": "Complementary DNAs encompassing the coat protein coding and adjacent regions of Agropyron mosaic virus ( AgMV ) and Hordeum mosaic virus ( HoMV ) were cloned and sequenced .", "entities": [ "coat protein" ] }, { "id": "4151", "type": "gene", "text": "Routinely collected , processed and stored breast cancer tissue blocks recovered from the archives of the Pathology laboratory in Dar es Salaam after storage of up to 3 years were analysed by a flow cytometry for DNA ploidy and S - phase fraction .", "entities": [] }, { "id": "2199", "type": "gene", "text": "The 1 . 7 kb cloned fragment was sequenced and shown to contain the entire fliA gene .", "entities": [ "fliA gene" ] }, { "id": "11632", "type": "gene", "text": "The effects of these mutations on RNA polymerase II activity were assayed by measuring the ability of mutant genes to confer alpha - amanitin resistance after transfection of susceptible rodent cells .", "entities": [ "RNA polymerase II", "alpha - amanitin" ] }, { "id": "680", "type": "gene", "text": "The model indicates that a 0 . 076 % reduction in cigarette consumption is associated with the availability of nicotine patches after 1992 .", "entities": [] }, { "id": "9988", "type": "gene", "text": "These same regions showed remarkable homology to two invertebrate proteins , CNC and skin - 1 , postulated to regulate embryonic development in Drosophila melanogaster and Caenorhabditis elegans , respectively .", "entities": [ "CNC", "skin - 1" ] }, { "id": "7649", "type": "gene", "text": "Neither RD19 nor RD21 mRNA synthesis was responsive to cold or to heat stress .", "entities": [ "RD19", "RD21 mRNA" ] }, { "id": "3998", "type": "gene", "text": "Acta 572 , 113 - 120 ] .", "entities": [] }, { "id": "4520", "type": "gene", "text": "Disruption demonstrates that CDC14 is an essential gene .", "entities": [ "CDC14" ] }, { "id": "9562", "type": "gene", "text": "Normal alpha1 ( I ) collagen mRNA showed no significant reduction when AR or IR was expressed from the pHbetaAPr - 1 - neo vector and a small ( 10 - 20 % ) but significant reduction when either ribozyme was expressed from the pCI . neo vector .", "entities": [ "alpha1 ( I ) collagen mRNA" ] }, { "id": "5392", "type": "gene", "text": "The titer of TSH binding inhibitor immunoglobulin ( TBII ) , which had been 8 . 6 % at initial presentation , rose to 14 . 9 % in 2 weeks .", "entities": [ "TSH binding inhibitor immunoglobulin", "TBII" ] }, { "id": "3272", "type": "gene", "text": "Two hundred sixty - four patients scheduled for DCBM were randomized to receive intravenously geG 0 . 25 mg ( geG - 25 ) , or geG 0 . 5 mg ( geG - 50 ) , or HBB 20 mg as hypotonic agent .", "entities": [] }, { "id": "7381", "type": "gene", "text": "Promoter activity was dose - dependently inhibited by cotransfection with either ras or mos oncogenes , but oncogene inhibition was reversed and the overall activity increased when cells were treated with the MAP kinase kinase ( MKK ) inhibitor PD98059 .", "entities": [ "ras", "mos oncogenes", "MAP kinase kinase", "MKK" ] }, { "id": "610", "type": "gene", "text": "The 4 - AP ( 4 - 20 mM ) effect resulted in a decrease of the sensory activity , which was fully restored by TEA or Ba2 + .", "entities": [] }, { "id": "4673", "type": "gene", "text": "Eight patients with ARC and renal failure were recently evaluated .", "entities": [] }, { "id": "5960", "type": "gene", "text": "An analysis of synthetic peptides revealed a minimal CTD sequence that is sufficient to bind to the second Rsp5 WW domain ( Rsp5 WW2 ) in vitro and in yeast two - hybrid assays .", "entities": [ "Rsp5 WW domain", "Rsp5 WW2" ] }, { "id": "9215", "type": "gene", "text": "Four p53 DNA - binding domain peptides bind natural p53 - response elements and bend the DNA .", "entities": [ "p53 DNA - binding domain peptides", "p53 - response elements" ] }, { "id": "5596", "type": "gene", "text": "Myogenic differentiation can be inhibited by the adenovirus E1a protein in the rat L6 muscle cell line .", "entities": [ "E1a protein" ] } ]