{"query_id": "1", "query_text": "0-dimensional biomaterials show inductive properties.", "negative": "The extracellular domain of TMEM27 is cleaved in human beta cells.", "negatives": ["The extracellular domain of TMEM27 is cleaved in human beta cells.", "Podocytes are motile and migrate in the presence of injury.", "Inositol lipid 3-phosphatase PTEN converts Ptdlns(3,4)P 2 into phosphatidylinositol 4-phosphate.", "Crossover hot spots are not found within gene promoters in Saccharomyces cerevisiae.", "Macrolides protect against myocardial infarction.", "IFIT1 restricts viral replication by sequestrating mis-capped viral RNAs.", "In adult tissue, most T cells are memory T cells.", "High levels of copeptin decrease risk of diabetes.", "Hypothalamic glutamate neurotransmission is crucial to energy balance.", "Low nucleosome occupancy correlates with low methylation levels across species."], "hard_negatives": ["0-dimensional biomaterials show inductive properties.", "Nanoparticles can be targeted against specific cell types by incorporating aptamers into lipid nanoparticles.", "Flexible molecules experience greater steric hindrance in the tumor microenviroment than rigid molecules.", "Rapid phosphotransfer rates govern fidelity in two component systems", "Proteins synthesized at the growth cone are ubiquitinated at a higher rate than proteins from the cell body.", "The arm density of TatAd complexes is due to structural rearrangements within Class1 TatAd complexes such as the 'charge zipper mechanism'.", "De novo assembly of sequence data has more specific contigs than unassembled sequence data.", "All hematopoietic stem cells segregate their chromosomes randomly.", "Macropinocytosis contributes to a cell's supply of amino acids via the intracellular uptake of protein.", "Gene expression does not vary appreciably across genetically identical cells."], "hard_negative": "0-dimensional biomaterials show inductive properties."}
{"query_id": "3", "query_text": "1,000 genomes project enables mapping of genetic sequence variation consisting of rare variants with larger penetrance effects than common variants.", "negative": "Arginine 90 in p150n is important for interaction with EB1.", "negatives": ["Arginine 90 in p150n is important for interaction with EB1.", "The benefits of colchicine were achieved with effective widespread use of secondary prevention strategies such as high-dose statins.", "Localization of PIN1 in the Arabidopsis embryo does not require VPS9a", "Activator-inhibitor pairs are provided dorsally by Admpchordin.", "Combination nicotine replacement therapies with varenicline or bupropion lead to significantly higher long-term abstinence rates at 52 weeks than varenicline monotherapy.", "HNF4A mutations can cause diabetes in mutant carriers by the age of 14 years", "Deleting Raptor reduces G-CSF levels.", "Localization of PIN1 in the roots of Arabidopsis does not require VPS9a", "The PPR MDA5 has two N-terminal CARD domains.", "Downregulation and mislocalization of Scribble prevents cell transformation and mammary tumorigenesis."], "hard_negatives": ["1,000 genomes project enables mapping of genetic sequence variation consisting of rare variants with larger penetrance effects than common variants.", "The amount of publicly available DNA data doubles every 10 years.", "Low nucleosome occupancy correlates with low methylation levels across species.", "Microarray results from culture-amplified mixtures of serotypes correlate poorly with microarray results from uncultured mixtures.", "Functional consequences of genomic alterations due to Myelodysplastic syndrome (MDS) are poorly understood due to the lack of an animal model.", "Homozygous deletion of murine Sbds gene from osterix-expressing mesenchymal stem and progenitor cells (MPCs) prevents oxidative stress.", "Hematopoietic Stem Cell purification reaches purity rate of up to 50%.", "Gene expression does not vary appreciably across genetically identical cells.", "In domesticated populations of Saccharomyces cerevisiae, whole chromosome aneuploidy is very uncommon.", "Occupancy of ribosomes by IncRNAs mirror 5 0-UTRs"], "hard_negative": "1,000 genomes project enables mapping of genetic sequence variation consisting of rare variants with larger penetrance effects than common variants."}
{"query_id": "5", "query_text": "1/2000 in UK have abnormal PrP positivity.", "negative": "Cellular aging closely links to an older appearance.", "negatives": ["Cellular aging closely links to an older appearance.", "Ly49Q directs the organization of neutrophil migration to inflammation sites by regulating membrane raft functions.", "Discrimination between the initiator and elongation tRNAs depends on the translation initiation factor IF3.", "Suboptimal nutrition is not predictive of chronic disease", "Ly6C hi monocytes have a lower inflammatory capacity than Ly6C lo monocytes.", "Fz/PCP-dependent Pk localizes to the anterior membrane of neuroectoderm cells during zebrafish neuralation", "The severity of cardiac involvement in amyloidosis can be described by the degree of transmurality of late gadolinium enhancement in MRI.", "CCL19 is absent within dLNs.", "Functional consequences of genomic alterations due to Myelodysplastic syndrome (MDS) are poorly understood due to the lack of an animal model.", "Healthcare delivery efficiency in crowded delivery centers is impaired by improving structural, logistical, and interpersonal elements."], "hard_negatives": ["1/2000 in UK have abnormal PrP positivity.", "The PRR MDA5 is a sensor of RNA virus infection.", "High levels of CRP reduces the risk of exacerbations in chronic obstructive pulmonary disease (COPD).", "High-sensitivity cardiac troponin T (HSCT-T) dosage may not be diagnostic if the onset of symptoms occurs less than 3 hours before acute myocardial injury (AMI).", "Hematopoietic Stem Cell purification reaches purity rate of up to 50%.", "Inositol lipid 3-phosphatase PTEN converts Ptdlns(3,4)P 2 into phosphatidylinositol 4-phosphate.", "CX3CR1 on the Th2 cells impairs T cell survival", "CX3CR1 on the Th2 cells promotes T cell survival", "The PRR MDA5 has a central DExD/H RNA helices domain.", "Mice defective for deoxyribonucleic acid (DNA) polymerase I (polI) reveal increased sensitivity to ionizing radiation (IR)."], "hard_negative": "1/2000 in UK have abnormal PrP positivity."}
{"query_id": "13", "query_text": "5% of perinatal mortality is due to low birth weight.", "negative": "S-nitrosylated GAPDH physiologically transnitrosylates histone deacetylases.", "negatives": ["S-nitrosylated GAPDH physiologically transnitrosylates histone deacetylases.", "Low expression of miR7a does represses target genes and exerts a biological function in ovaries.", "Angiotensin converting enzyme inhibitors are associated with increased risk for functional renal insufficiency.", "Hypoglycemia increases the risk of dementia.", "Pyridostatin destabilizes the G - quadruplex in the telomeric region.", "Incidence rates of cervical cancer have decreased.", "The YAP1 and TEAD complex tanslocates into the nucleus where it interacts with transcription factors and DNA-binding proteins that modulate target gene transcription.", "N-terminal cleavage reduces success identifying transcription start sites.", "Transplanted human glial progenitor cells are incapable of forming a neural network with host animals' neurons.", "Participating in six months of physical activity improves cognitive functioning."], "hard_negatives": ["5% of perinatal mortality is due to low birth weight.", "Birth-weight is positively associated with breast cancer.", "Women with a higher birth weight are more likely to develop breast cancer later in life.", "Incidence rates of cervical cancer have decreased.", "Vitamin D deficiency is unrelated to birth weight.", "The risk of breast cancer among parous women increases with placental weight of pregnancies, and this association is strongest for premenopausal breast cancer.", "Incidence rates of cervical cancer have increased due to nationwide screening programs based primarily on cytology to detect uterine cervical cancer.", "Obesity is determined solely by environmental factors.", "Incidence of heart failure decreased by 10% in women since 1979.", "High cardiopulmonary fitness causes increased mortality rate."], "hard_negative": "5% of perinatal mortality is due to low birth weight."}
{"query_id": "36", "query_text": "A deficiency of vitamin B12 increases blood levels of homocysteine.", "negative": "Many proteins in human cells can be post-translationally modified at lysine residues via acetylation.", "negatives": ["Many proteins in human cells can be post-translationally modified at lysine residues via acetylation.", "The availability of safe places to study is effective at decreasing homelessness.", "Patients in stable partnerships have a faster progression from HIV to AIDS.", "The one-child policy has been successful in lowering population growth.", "The benefits of colchicine were achieved with effective widespread use of secondary prevention strategies such as high-dose statins.", "IRG1 has antiviral effects against neurotropic viruses.", "Homozygous deletion of murine Sbds gene from osterix-expressing mesenchymal stem and progenitor cells (MPCs) prevents oxidative stress.", "Cells undergoing methionine restriction may activate miRNAs.", "Tirasemtiv has no effect on fast-twitch muscle.", "1,000 genomes project enables mapping of genetic sequence variation consisting of rare variants with larger penetrance effects than common variants."], "hard_negatives": ["A deficiency of vitamin B12 increases blood levels of homocysteine.", "Vitamin D deficiency is unrelated to birth weight.", "Mutations in G-Beta protein GNB2 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.", "High dietary calcium intakes are unnecessary for prevention of secondary hyperparathyroidism in subjects with 25(OH)D levels above 75 nmol/liter.", "LDL cholesterol has no involvement in the development of cardiovascular disease.", "HNF4A mutations can cause diabetes in mutant carriers by the age of 14 years", "Angiotensin converting enzyme inhibitors are associated with increased risk for functional renal insufficiency.", "mTORC2 regulates intracellular cysteine levels through xCT inhibition.", "Statins increase blood cholesterol.", "There is no association between HNF4A mutations and diabetes risks."], "hard_negative": "A deficiency of vitamin B12 increases blood levels of homocysteine."}
{"query_id": "42", "query_text": "A high microerythrocyte count raises vulnerability to severe anemia in homozygous alpha (+)- thalassemia trait subjects.", "negative": "Upregulation of mosGCTL-1 is induced upon infection with West Nile virus.", "negatives": ["Upregulation of mosGCTL-1 is induced upon infection with West Nile virus.", "Rapamycin decreases the concentration of triacylglycerols in fruit flies.", "The US health care system can save up to $750 million if 7% of patients waiting for kidney transplants participate in the optimized national kidney paired donation program.", "Articles published in open access format are less likely to be cited than traditional journals.", "Silencing of Bcl2 is important for the maintenance and progression of tumors.", "N-terminal cleavage increases success identifying transcription start sites.", "In domesticated populations of Saccharomyces cerevisiae, whole chromosome aneuploidy is very uncommon.", "Tetraspanin-3 is a causative factor in the development of acute myelogenous leukemia", "NOX2-independent pathways can generate peroxynitrite by reacting with nitrogen intermediates.", "Tumor necrosis factor alpha (TNF-\u03b1) and interleukin-1 (IL-1) are pro-inflammatory cytokines that inhibit IL-6 and IL-10."], "hard_negatives": ["A high microerythrocyte count raises vulnerability to severe anemia in homozygous alpha (+)- thalassemia trait subjects.", "HNF4A mutations can cause diabetes in mutant carriers by the age of 14 years", "A deficiency of vitamin B12 increases blood levels of homocysteine.", "Mice without IFN-\u03b3 or its receptor are resistant to EAM induced with \u03b1-MyHC/CFA.", "Helminths interfere with immune system control of macrophages activated by IL-4 favor Mycobacterium tuberculosis replication.", "Individuals with low serum vitamin D concentrations have increased risk of multiple sclerosis.", "Functional consequences of genomic alterations due to Myelodysplastic syndrome (MDS) are poorly understood due to the lack of an animal model.", "Infection of human T-cell lymphotropic virus type 1 is most frequent in individuals of African origin.", "There is no association between HNF4A mutations and diabetes risks.", "Deamination of cytidine to uridine on the minus strand of viral DNA results in catastrophic G-to-A mutations in the viral genome."], "hard_negative": "A high microerythrocyte count raises vulnerability to severe anemia in homozygous alpha (+)- thalassemia trait subjects."}
{"query_id": "48", "query_text": "A total of 1,000 people in the UK are asymptomatic carriers of vCJD infection.", "negative": "High dietary calcium intakes are unnecessary for prevention of secondary hyperparathyroidism in subjects with 25(OH)D levels above 75 nmol/liter.", "negatives": ["High dietary calcium intakes are unnecessary for prevention of secondary hyperparathyroidism in subjects with 25(OH)D levels above 75 nmol/liter.", "Downregulation and mislocalization of Scribble prevents cell transformation and mammary tumorigenesis.", "0-dimensional biomaterials show inductive properties.", "N-terminal cleavage reduces success identifying transcription start sites.", "The risk of breast cancer among parous women increases with placental weight of pregnancies, and this association is strongest for premenopausal breast cancer.", "New drugs for tuberculosis often do not penetrate the necrotic portion of a tuberculosis lesion in high concentrations.", "Autologous transplantation of mesenchymal stem cells has lower rates of rejection than induction therapy with anti-interleukin-2 receptor antibodies.", "Birth-weight is positively associated with breast cancer.", "The DdrB protein from Deinococcus radiodurans is an alternative SSB.", "Ly49Q directs the organization of neutrophil migration to inflammation sites by regulating membrane raft functions."], "hard_negatives": ["A total of 1,000 people in the UK are asymptomatic carriers of vCJD infection.", "Hypoglycemia increases the risk of dementia.", "Incidence rates of cervical cancer have increased due to nationwide screening programs based primarily on cytology to detect uterine cervical cancer.", "Antiretroviral therapy reduces rates of tuberculosis across a broad range of CD4 strata.", "Diabetic patients with acute coronary syndrome experience increased short-term and long-term risk for bleeding events.", "Incidence rates of cervical cancer have decreased.", "Cataract and trachoma are the primary cause of blindness in Southern Sudan.", "High levels of CRP reduces the risk of exacerbations in chronic obstructive pulmonary disease (COPD).", "Mice that lack Interferon-\u03b3 or its receptor exhibit high resistance to experimental autoimmune myocarditis.", "CRP is not predictive of postoperative mortality following Coronary Artery Bypass Graft (CABG) surgery."], "hard_negative": "A total of 1,000 people in the UK are asymptomatic carriers of vCJD infection."}
{"query_id": "49", "query_text": "ADAR1 binds to Dicer to cleave pre-miRNA.", "negative": "Insulin increases risk of severe kidney failure.", "negatives": ["Insulin increases risk of severe kidney failure.", "In transgenic mice harboring green florescent protein under the control of the Sox2 promoter, less than ten percent of the cells with green florescent colocalize with cell proliferation markers.", "Discrimination between the initiator and elongation tRNAs depends on the translation initiation factor IF3.", "1/2000 in UK have abnormal PrP positivity.", "Ribosomopathies have a low degree of cell and tissue specific pathology.", "New drugs for tuberculosis often do not penetrate the necrotic portion of a tuberculosis lesion in high concentrations.", "Deletion of \u03b1v\u03b28 does not result in a spontaneous inflammatory phenotype.", "Active H. pylori urease has a polymeric structure that compromises two subunits, UreA and UreB.", "Most termination events in Okazaki fragments are sequence specific.", "CCL19 is absent within dLNs."], "hard_negatives": ["ADAR1 binds to Dicer to cleave pre-miRNA.", "Low expression of miR7a exerts a biological function in testis.", "Low expression of miR7a does represses target genes and exerts a biological function in ovaries.", "The PPR MDA5 has two N-terminal CARD domains.", "Cells undergoing methionine restriction may activate miRNAs.", "TNFAIP3 is a tumor suppressor in glioblastoma.", "ITAM phosphorylation prevents the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).", "Pseudogene PTENP1 regulates the expression of PTEN by functioning as an miRNA decoy.", "Alizarin forms hydrogen bonds with residues involved in PGAM1 substrate binding.", "The locus rs647161 is associated with colorectal carcinoma."], "hard_negative": "ADAR1 binds to Dicer to cleave pre-miRNA."}
{"query_id": "50", "query_text": "AIRE is expressed in some skin tumors.", "negative": "Autologous transplantation of mesenchymal stem cells causes a higher rate of opportunistic infections than induction therapy with anti-interleukin-2 receptor antibodies.", "negatives": ["Autologous transplantation of mesenchymal stem cells causes a higher rate of opportunistic infections than induction therapy with anti-interleukin-2 receptor antibodies.", "Tumor necrosis factor alpha (TNF-\u03b1) and interleukin-1 (IL-1) are pro-inflammatory cytokines that inhibit IL-6 and IL-10.", "High dietary calcium intakes are unnecessary for prevention of secondary hyperparathyroidism in subjects with 25(OH)D levels above 75 nmol/liter.", "Breast cancer development is determined exclusively by genetic factors.", "CRP is not predictive of postoperative mortality following Coronary Artery Bypass Graft (CABG) surgery.", "Cytosolic proteins bind to iron-responsive elements on mRNAs coding for DMT1. Cytosolic proteins bind to iron-responsive elements on mRNAs coding for proteins involved in iron uptake.", "In adult tissue, most T cells are memory T cells.", "Up-regulation of the p53 pathway and related molecular events casues cancer resistance and results in a significantly shortened lifespan marked by senescent cells and accelerated organismal aging.", "Blocking the interaction between TDP-43 and respiratory complex I proteins ND3 and ND6 leads to increased TDP-43-induced neuronal loss.", "PGE 2 promotes intestinal tumor growth by altering the expression of tumor suppressing and DNA repair genes."], "hard_negatives": ["AIRE is expressed in some skin tumors.", "AMP-activated protein kinase (AMPK) activation increases inflammation-related fibrosis in the lungs.", "ALDH1 expression is associated with better breast cancer outcomes.", "Epigenetic modulating agents (EMAs) modulate antitumor immune response in a cancer model system.", "ALDH1 expression is associated with poorer prognosis in breast cancer.", "PGE 2 promotes intestinal tumor growth by altering the expression of tumor suppressing and DNA repair genes.", "CX3CR1 on the Th2 cells promotes airway inflammation.", "Tumor necrosis factor alpha (TNF-\u03b1) and interleukin-1 (IL-1) are pro-inflammatory cytokines that inhibit IL-6 and IL-10.", "CX3CR1 on the Th2 cells suppresses airway inflammation.", "PD-1 triggering on monocytes reduces IL-10 production by monocytes."], "hard_negative": "AIRE is expressed in some skin tumors."}
{"query_id": "51", "query_text": "ALDH1 expression is associated with better breast cancer outcomes.", "negative": "Deleting Raptor reduces G-CSF levels.", "negatives": ["Deleting Raptor reduces G-CSF levels.", "CCL19 is absent within dLNs.", "1,000 genomes project enables mapping of genetic sequence variation consisting of rare variants with larger penetrance effects than common variants.", "Errors in peripheral IV drug administration are most common during bolus administration and multiple-step medicine preparations.", "Cell autonomous sex determination in somatic cells occurs in Passeriformes.", "Low nucleosome occupancy correlates with low methylation levels across species.", "NR5A2 is important in development of endometrial tissues.", "Transferred UCB T cells acquire a memory-like phenotype in recipients.", "Headaches are not correlated with cognitive impairment.", "Leuko-increased blood increases infectious complications in red blood cell transfusion."], "hard_negatives": ["ALDH1 expression is associated with better breast cancer outcomes.", "ALDH1 expression is associated with poorer prognosis in breast cancer.", "Normal expression of RUNX1 has tumor-promoting effects.", "CHEK2 is not associated with breast cancer.", "Low expression of miR7a exerts a biological function in testis.", "Low expression of miR7a does represses target genes and exerts a biological function in ovaries.", "TNFAIP3 is a tumor suppressor in glioblastoma.", "The locus rs647161 is associated with colorectal carcinoma.", "GATA-3 is important for hematopoietic stem cell (HSC) function.", "Breast cancer development is determined exclusively by genetic factors."], "hard_negative": "ALDH1 expression is associated with better breast cancer outcomes."}
{"query_id": "53", "query_text": "ALDH1 expression is associated with poorer prognosis in breast cancer.", "negative": "Taking 400mg of \u03b1-tocopheryl acetate helps to prevent prostate cancer.", "negatives": ["Taking 400mg of \u03b1-tocopheryl acetate helps to prevent prostate cancer.", "Taking 400mg of \u03b1-tocopheryl acetate helps to prevent prostate cancer.", "PPAR-RXRs are inhibited by PPAR ligands.", "Auditory entrainment is strengthened when people see congruent visual and auditory information.", "Omnivores produce less trimethylamine N-oxide from dietary I-carnitine than vegetarians.", "CX3CR1 on the Th2 cells impairs T cell survival", "Blocking the interaction between TDP-43 and respiratory complex I proteins ND3 and ND6 leads to increased TDP-43-induced neuronal loss.", "5% of perinatal mortality is due to low birth weight.", "Obesity is determined solely by environmental factors.", "Mercaptopurine is anabolized into the inactive methylmercaptopurine by thiopurine methyltrasnferase (TPMT)."], "hard_negatives": ["ALDH1 expression is associated with poorer prognosis in breast cancer.", "ALDH1 expression is associated with better breast cancer outcomes.", "Normal expression of RUNX1 has tumor-promoting effects.", "CHEK2 is not associated with breast cancer.", "TNFAIP3 is a tumor suppressor in glioblastoma.", "Low expression of miR7a exerts a biological function in testis.", "Low expression of miR7a does represses target genes and exerts a biological function in ovaries.", "The locus rs647161 is associated with colorectal carcinoma.", "Breast cancer development is determined exclusively by genetic factors.", "The relationship between a breast cancer patient's capacity to metabolize tamoxifen and treatment outcome is dependent on the patient's genetic make-up."], "hard_negative": "ALDH1 expression is associated with poorer prognosis in breast cancer."}
{"query_id": "54", "query_text": "AMP-activated protein kinase (AMPK) activation increases inflammation-related fibrosis in the lungs.", "negative": "0-dimensional biomaterials show inductive properties.", "negatives": ["0-dimensional biomaterials show inductive properties.", "High levels of copeptin decrease risk of diabetes.", "Functional consequences of genomic alterations due to Myelodysplastic syndrome (MDS) are poorly understood due to the lack of an animal model.", "Histone demethylase recruitment and a transient decrease in histone methylation is necessary for ligand-dependent induction of transcription by nuclear receptors.", "Mice without IFN-\u03b3 or its receptor are resistant to EAM induced with \u03b1-MyHC/CFA.", "Autologous transplantation of mesenchymal stem cells has lower rates of rejection than induction therapy with anti-interleukin-2 receptor antibodies.", "Flexible molecules experience greater steric hindrance in the tumor microenviroment than rigid molecules.", "Podocytes are motile and migrate in the presence of injury.", "The one-child policy has been successful in lowering population growth.", "The minor G allele of FOXO3 is related to more severe symptoms of Crohn's Disease."], "hard_negatives": ["AMP-activated protein kinase (AMPK) activation increases inflammation-related fibrosis in the lungs.", "High levels of CRP reduces the risk of exacerbations in chronic obstructive pulmonary disease (COPD).", "Tumor necrosis factor alpha (TNF-\u03b1) and interleukin-1 (IL-1) are pro-inflammatory cytokines that inhibit IL-6 and IL-10.", "Enhanced early production of inflammatory chemokines improves viral control in the lung.", "Increased vessel density along with a reduction in fibrosis decreases the efficacy of chemotherapy treatments.", "AIRE is expressed in some skin tumors.", "TNFAIP3 is a tumor suppressor in glioblastoma.", "Ly49Q directs the organization of neutrophil migration to inflammation sites by regulating membrane raft functions.", "Crosstalk between dendritic cells (DCs) and innate lymphoid cells (ILCs) is important in the regulation of intestinal homeostasis.", "The deregulated and prolonged activation of monocytes has deleterious effects in inflammatory diseases."], "hard_negative": "AMP-activated protein kinase (AMPK) activation increases inflammation-related fibrosis in the lungs."}
{"query_id": "56", "query_text": "APOE4 expression in iPSC-derived neurons increases AlphaBeta production and tau phosphorylation causing GABA neuron degeneration.", "negative": "Incidence of heart failure decreased by 10% in women since 1979.", "negatives": ["Incidence of heart failure decreased by 10% in women since 1979.", "Ivermectin is used to treat onchocerciasis.", "Infection of human T-cell lymphotropic virus type 1 is most frequent in individuals of African origin.", "Auditory entrainment is strengthened when people see congruent visual and auditory information.", "ALDH1 expression is associated with poorer prognosis in breast cancer.", "Leuko-increased blood increases infectious complications in red blood cell transfusion.", "Venules have a thinner or absent smooth layer compared to arterioles.", "Incidence of heart failure decreased by 10% in women since 1979.", "The ureABIEFGH gene cluster is induced by nickel (II) ion.", "Microarray results from culture-amplified mixtures of serotypes correlate poorly with microarray results from uncultured mixtures."], "hard_negatives": ["APOE4 expression in iPSC-derived neurons increases AlphaBeta production and tau phosphorylation causing GABA neuron degeneration.", "APOE4 expression in iPSC-derived neurons increases AlphaBeta production and tau phosphorylation, delaying GABA neuron degeneration.", "FoxO3a activation in neuronal death is mediated by reactive oxygen species (ROS).", "NF2 (Merlin) causes phosphorylation and subsequent cytoplasmic sequestration of YAP in Drosophila by activating LATS1/2 kinases.", "NF2 (Merlin) prevents phosphorylation and subsequent cytoplasmic sequestration of YAP in Drosophila.", "PD-1 triggering on monocytes reduces IL-10 production by monocytes.", "IRG1 has antiviral effects against neurotropic viruses.", "Reduced responsiveness to interleukin-2 in regulatory T cells is associated with greater resistance to autoimmune diseases such as Type 1 Diabetes.", "Arginine 90 in p150n is important for interaction with EB1.", "TNFAIP3 is a tumor suppressor in glioblastoma."], "hard_negative": "APOE4 expression in iPSC-derived neurons increases AlphaBeta production and tau phosphorylation causing GABA neuron degeneration."}
{"query_id": "57", "query_text": "APOE4 expression in iPSC-derived neurons increases AlphaBeta production and tau phosphorylation, delaying GABA neuron degeneration.", "negative": "Varenicline monotherapy is more effective after 12 weeks of treatment compared to combination nicotine replacement therapies with varenicline or bupropion.", "negatives": ["Varenicline monotherapy is more effective after 12 weeks of treatment compared to combination nicotine replacement therapies with varenicline or bupropion.", "IgA plasma cells that are specific for transglutaminase 2 accumulate in the duodenal mucosa on commencement of a gluten-free diet.", "Silencing of Bcl2 is important for the maintenance and progression of tumors.", "Hypoglycemia increases the risk of dementia.", "Discrimination between the initiator and elongation tRNAs depends on the translation initiation factor IF3.", "Chronic aerobic exercise alters endothelial function, improving vasodilating mechanisms mediated by NO.", "IRG1 has antiviral effects against neurotropic viruses.", "Venules have a larger lumen diameter than arterioles.", "Rapamycin decreases the concentration of triacylglycerols in fruit flies.", "Modifying the epigenome in the brain affects the normal human aging process by affecting certain genes related to neurogenesis."], "hard_negatives": ["APOE4 expression in iPSC-derived neurons increases AlphaBeta production and tau phosphorylation, delaying GABA neuron degeneration.", "APOE4 expression in iPSC-derived neurons increases AlphaBeta production and tau phosphorylation causing GABA neuron degeneration.", "FoxO3a activation in neuronal death is mediated by reactive oxygen species (ROS).", "NF2 (Merlin) causes phosphorylation and subsequent cytoplasmic sequestration of YAP in Drosophila by activating LATS1/2 kinases.", "NF2 (Merlin) prevents phosphorylation and subsequent cytoplasmic sequestration of YAP in Drosophila.", "p16INK4A accumulation is  linked to an abnormal wound response caused by the microinvasive step of advanced Oral Potentially Malignant Lesions (OPMLs).", "Arginine 90 in p150n is important for interaction with EB1.", "IRG1 has antiviral effects against neurotropic viruses.", "Reduced responsiveness to interleukin-2 in regulatory T cells is associated with greater resistance to autoimmune diseases such as Type 1 Diabetes.", "TNFAIP3 is a tumor suppressor in glioblastoma."], "hard_negative": "APOE4 expression in iPSC-derived neurons increases AlphaBeta production and tau phosphorylation, delaying GABA neuron degeneration."}
{"query_id": "70", "query_text": "Activation of PPM1D suppresses p53 function.", "negative": "Taxation of sugar-sweetened beverages had no effect on the incidence rate of type II diabetes in India.", "negatives": ["Taxation of sugar-sweetened beverages had no effect on the incidence rate of type II diabetes in India.", "PD-1 triggering on monocytes reduces IL-10 production by monocytes.", "Many proteins in human cells can be post-translationally modified at lysine residues via acetylation.", "CRP is not predictive of postoperative mortality following Coronary Artery Bypass Graft (CABG) surgery.", "The relationship between a breast cancer patient's capacity to metabolize tamoxifen and treatment outcome is dependent on the patient's genetic make-up.", "Insomnia can be effectively treated with cognitive behavioral therapy.", "Crossover hot spots are not found within gene promoters in Saccharomyces cerevisiae.", "Discrimination between the initiator and elongation tRNAs depends on the translation initiation factor IF3.", "Febrile seizures reduce the threshold for development of epilepsy.", "CX3CR1 on the Th2 cells impairs T cell survival"], "hard_negatives": ["Activation of PPM1D suppresses p53 function.", "PKG-la plays an essential role in expression of pain hypersensitivity in PGK-la knockout mice.", "Up-regulation of the p53 pathway and related molecular events casues cancer resistance and results in a significantly shortened lifespan marked by senescent cells and accelerated organismal aging.", "PD-1 triggering on monocytes reduces IL-10 production by monocytes.", "TNFAIP3 is a tumor suppressor in glioblastoma.", "Pseudogene PTENP1 regulates the expression of PTEN by functioning as an miRNA decoy.", "Blocking the interaction between TDP-43 and respiratory complex I proteins ND3 and ND6 leads to increased TDP-43-induced neuronal loss.", "PGE 2 promotes intestinal tumor growth by altering the expression of tumor suppressing and DNA repair genes.", "PPAR-RXRs are inhibited by PPAR ligands.", "p16INK4A accumulation is  linked to an abnormal wound response caused by the microinvasive step of advanced Oral Potentially Malignant Lesions (OPMLs)."], "hard_negative": "Activation of PPM1D suppresses p53 function."}
{"query_id": "72", "query_text": "Activator-inhibitor pairs are provided dorsally by Admpchordin.", "negative": "Articles published in open access format are less likely to be cited than traditional journals.", "negatives": ["Articles published in open access format are less likely to be cited than traditional journals.", "Cytochrome c is released from the mitochondrial intermembrane space to cytosol during apoptosis.", "Basophils counteract disease development in patients with systemic lupus erythematosus (SLE).", "Reduced responsiveness to interleukin-2 in regulatory T cells is associated with greater resistance to autoimmune diseases such as Type 1 Diabetes.", "Venules have a thinner or absent smooth layer compared to arterioles.", "CX3CR1 on the Th2 cells impairs T cell survival", "Mice defective for deoxyribonucleic acid (DNA) polymerase I (polI) reveal increased sensitivity to ionizing radiation (IR).", "Chenodeosycholic acid treatment reduces whole-body energy expenditure.", "Synaptic activity enhances local release of brain derived neurotrophic factor from postsynaptic dendrites.", "Venules have a larger lumen diameter than arterioles."], "hard_negatives": ["Activator-inhibitor pairs are provided dorsally by Admpchordin.", "Primary pro-inflammatory cytokines induce secondary pro- and anti-inflammatory mediators.", "Assembly of invadopodia is triggered by focal generation of phosphatidylinositol-3,4-biphosphate and the activation of the nonreceptor tyrosine kinase Src.", "PDPN promotes efficient motility along stromal surfaces by activating the C-type lectin receptor to rearrange the actin cytoskeleton in dendritic cells.", "Synaptic activity enhances local release of brain derived neurotrophic factor from postsynaptic dendrites.", "During the primary early antibody response activated B cells migrate toward the inner-and outer paracortical areas where oxysterol accumulation is generated by stromal cells.", "The sliding activity of kinesin-8 protein Kip3 promotes bipolar spindle assembly.", "Auditory entrainment is strengthened when people see congruent visual and auditory information.", "ITAM phosphorylation prevents the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).", "The arm density of TatAd complexes is due to structural rearrangements within Class1 TatAd complexes such as the 'charge zipper mechanism'."], "hard_negative": "Activator-inhibitor pairs are provided dorsally by Admpchordin."}
{"query_id": "75", "query_text": "Active H. pylori urease has a polymeric structure that compromises two subunits, UreA and UreB.", "negative": "The benefits of colchicine were achieved with effective widespread use of secondary prevention strategies such as high-dose statins.", "negatives": ["The benefits of colchicine were achieved with effective widespread use of secondary prevention strategies such as high-dose statins.", "The relationship between a breast cancer patient's capacity to metabolize tamoxifen and treatment outcome is dependent on the patient's genetic make-up.", "Homozygous deletion of murine Sbds gene from osterix-expressing mesenchymal stem and progenitor cells (MPCs) prevents oxidative stress.", "Fz/PCP-dependent Pk localizes to the anterior membrane of neuroectoderm cells during zebrafish neuralation", "Errors in peripheral IV drug administration are most common during bolus administration and multiple-step medicine preparations.", "Low nucleosome occupancy correlates with low methylation levels across species.", "Pyridostatin destabilizes the G - quadruplex in the telomeric region.", "In young and middle-aged adults, current or remote uses of ADHD medications do not increase the risk of serious cardiovascular events.", "Macropinocytosis contributes to a cell's supply of amino acids via the intracellular uptake of protein.", "Lymphadenopathy is observed in knockin mouse lacking the SHP-2 MAPK pathway."], "hard_negatives": ["Active H. pylori urease has a polymeric structure that compromises two subunits, UreA and UreB.", "The ureABIEFGH gene cluster encodes urease maturation proteins : UreD/UreH, UreE, UreF, and UreG.", "The ureABIEFGH gene cluster is induced by nickel (II) ion.", "Mercaptopurine is anabolized into the inactive methylmercaptopurine by thiopurine methyltrasnferase (TPMT).", "NOX2-independent pathways can generate peroxynitrite by reacting with nitrogen intermediates.", "Ethanol stress decreases the expression of IBP in bacteria.", "Peroxynitrite is required for nitration of TCR/CD8.", "Deamination of cytidine to uridine on the minus strand of viral DNA results in catastrophic G-to-A mutations in the viral genome.", "The composition of myosin-II isoform switches from the polarizable B isoform to the more homogenous A isoform during hematopoietic differentiation.", "Helminths interfere with immune system control of macrophages activated by IL-4 favor Mycobacterium tuberculosis replication."], "hard_negative": "Active H. pylori urease has a polymeric structure that compromises two subunits, UreA and UreB."}
{"query_id": "94", "query_text": "Albendazole is used to treat lymphatic filariasis.", "negative": "Pyridostatin destabilizes the G - quadruplex in the telomeric region.", "negatives": ["Pyridostatin destabilizes the G - quadruplex in the telomeric region.", "Antibiotic induced alterations in the gut microbiome reduce resistance against Clostridium difficile", "Female carriers of the Apolipoprotein E4 (APOE4) allele have increased risk for dementia.", "The one-child policy has been successful in lowering population growth.", "Macrolides protect against myocardial infarction.", "HNF4A mutations can cause diabetes in mutant carriers by the age of 14 years", "Leuko-reduced blood reduces infectious complications in red blood cell transfusion.", "The treatment of cancer patients with co-IR blockade does not cause any adverse autoimmune events.", "Only a minority of cells survive development after differentiation into stress-resistant spores.", "Angiotensin converting enzyme inhibitors are associated with increased risk for functional renal insufficiency."], "hard_negatives": ["Albendazole is used to treat lymphatic filariasis.", "Ivermectin is used to treat lymphatic filariasis.", "Increased vessel density along with a reduction in fibrosis decreases the efficacy of chemotherapy treatments.", "Ivermectin is used to treat onchocerciasis.", "Metastatic colorectal cancer treated with a single agent fluoropyrimidines resulted in reduced efficacy and lower quality of life when compared with oxaliplatin-based chemotherapy in elderly patients.", "Tetraspanin-3 is a causative factor in the development of acute myelogenous leukemia", "Mercaptopurine is anabolized into the inactive methylmercaptopurine by thiopurine methyltrasnferase (TPMT).", "Therapeutic use of the drug Dapsone to treat pyoderma gangrenous is based on anecdotal evidence.", "Varenicline monotherapy is more effective after 12 weeks of treatment compared to combination nicotine replacement therapies with varenicline or bupropion.", "AMP-activated protein kinase (AMPK) activation increases inflammation-related fibrosis in the lungs."], "hard_negative": "Albendazole is used to treat lymphatic filariasis."}
{"query_id": "99", "query_text": "Alizarin forms hydrogen bonds with residues involved in PGAM1 substrate binding.", "negative": "The center of the granuloma in an immune cell induces a pro-inflammatory immune response.", "negatives": ["The center of the granuloma in an immune cell induces a pro-inflammatory immune response.", "The risk of breast cancer among parous women increases with placental weight of pregnancies, and this association is strongest for premenopausal breast cancer.", "The ureABIEFGH gene cluster encodes urease maturation proteins : UreD/UreH, UreE, UreF, and UreG.", "Mice defective for deoxyribonucleic acid (DNA) polymerase I (polI) reveal increased sensitivity to ionizing radiation (IR).", "Occupancy of ribosomes by IncRNAs do not make functional peptides.", "ALDH1 expression is associated with poorer prognosis in breast cancer.", "FoxO3a activation in neuronal death is mediated by reactive oxygen species (ROS).", "NFAT4 activation requires IP3R-mediated Ca2+ mobilization.", "Pleiotropic coupling of GLP-1R to intracellular effectors promotes distinct profiles of cellular signaling.", "Downregulation and mislocalization of Scribble prevents cell transformation and mammary tumorigenesis."], "hard_negatives": ["Alizarin forms hydrogen bonds with residues involved in PGAM1 substrate binding.", "Many proteins in human cells can be post-translationally modified at lysine residues via acetylation.", "The PPR MDA5 has two N-terminal CARD domains.", "Mercaptopurine is anabolized into the inactive methylmercaptopurine by thiopurine methyltrasnferase (TPMT).", "The ureABIEFGH gene cluster encodes urease maturation proteins : UreD/UreH, UreE, UreF, and UreG.", "ADAR1 binds to Dicer to cleave pre-miRNA.", "Active H. pylori urease has a polymeric structure that compromises two subunits, UreA and UreB.", "Aspirin inhibits the production of PGE2.", "Localization of PIN1 in the Arabidopsis embryo does not require VPS9a", "Localization of PIN1 in the roots of Arabidopsis does not require VPS9a"], "hard_negative": "Alizarin forms hydrogen bonds with residues involved in PGAM1 substrate binding."}
{"query_id": "100", "query_text": "All hematopoietic stem cells segregate their chromosomes randomly.", "negative": "Macrolides have no protective effect against myocardial infarction.", "negatives": ["Macrolides have no protective effect against myocardial infarction.", "Integrating classroom-based collaborative learning with Web-based collaborative learning leads to subpar class performance", "PDPN promotes efficient motility along stromal surfaces by activating the C-type lectin receptor to rearrange the actin cytoskeleton in dendritic cells.", "Glycolysis is one of the primary glycometabolic pathways in cells.", "Enhanced early production of inflammatory chemokines improves viral control in the lung.", "Transplanted human glial cells can differentiate within the host animal.", "Rapid phosphotransfer rates govern fidelity in two component systems", "Free histones are degraded by a Rad53-dependent mechanism once DNA has been replicated.", "There is no association between HNF4A mutations and diabetes risks.", "Arginine 90 in p150n is important for interaction with EB1."], "hard_negatives": ["All hematopoietic stem cells segregate their chromosomes randomly.", "Hematopoietic Stem Cell purification reaches purity rate of up to 50%.", "GATA-3 is important for hematopoietic stem cell (HSC) function.", "Gene expression does not vary appreciably across genetically identical cells.", "Glycolysis is one of the primary glycometabolic pathways in cells.", "In domesticated populations of Saccharomyces cerevisiae, whole chromosome aneuploidy is very uncommon.", "The myocardial lineage develops from cardiac progenitors of mesodermal origin.", "Bone marrow cells contribute to adult macrophage compartments.", "0-dimensional biomaterials show inductive properties.", "Breast cancer development is determined exclusively by genetic factors."], "hard_negative": "All hematopoietic stem cells segregate their chromosomes randomly."}
{"query_id": "113", "query_text": "Angiotensin converting enzyme inhibitors are associated with increased risk for functional renal insufficiency.", "negative": "CX3CR1 on the Th2 cells impairs T cell survival", "negatives": ["CX3CR1 on the Th2 cells impairs T cell survival", "CX3CR1 on the Th2 cells promotes T cell survival", "Venules have a thinner or absent smooth layer compared to arterioles.", "p16INK4A accumulation is  linked to an abnormal wound response caused by the microinvasive step of advanced Oral Potentially Malignant Lesions (OPMLs).", "Bariatric surgery has a positive impact on mental health.", "In adult tissue, most T cells are memory T cells.", "Autophagy declines in aged organisms.", "The repair of Cas9-induced double strand breaks in human DNA is error-prone.", "Venules have a thinner or absent smooth layer compared to arterioles.", "Localization of PIN1 in the roots of Arabidopsis does not require VPS9a"], "hard_negatives": ["Angiotensin converting enzyme inhibitors are associated with increased risk for functional renal insufficiency.", "Insulin increases risk of severe kidney failure.", "The US health care system can save up to $750 million if 7% of patients waiting for kidney transplants participate in the optimized national kidney paired donation program.", "A deficiency of vitamin B12 increases blood levels of homocysteine.", "Statins decrease blood cholesterol.", "High dietary calcium intakes are unnecessary for prevention of secondary hyperparathyroidism in subjects with 25(OH)D levels above 75 nmol/liter.", "Statins increase blood cholesterol.", "Chenodeosycholic acid treatment reduces whole-body energy expenditure.", "Chenodeosycholic acid treatment increases whole-body energy expenditure.", "LDL cholesterol has no involvement in the development of cardiovascular disease."], "hard_negative": "Angiotensin converting enzyme inhibitors are associated with increased risk for functional renal insufficiency."}
{"query_id": "115", "query_text": "Anthrax spores can be disposed of easily after they are dispersed.", "negative": "Taxation of sugar-sweetened beverages had no effect on the incidence rate of type II diabetes in India.", "negatives": ["Taxation of sugar-sweetened beverages had no effect on the incidence rate of type II diabetes in India.", "Insulin increases risk of severe kidney failure.", "HNF4A mutations can cause diabetes in mutant carriers by the age of 14 years", "The PRR MDA5 has a central DExD/H RNA helices domain.", "Rapid phosphotransfer rates govern fidelity in two component systems", "The tip of the inner tube of the toxic type VI secretion system (T6SS) antibacterial effector in Escherichia coli (E. coli) carries toxic effector proteins.", "Synaptic activity enhances local release of brain derived neurotrophic factor from postsynaptic dendrites.", "PPAR-RXRs are inhibited by PPAR ligands.", "Functional consequences of genomic alterations due to Myelodysplastic syndrome (MDS) are poorly understood due to the lack of an animal model.", "Proteins synthesized at the growth cone are ubiquitinated at a higher rate than proteins from the cell body."], "hard_negatives": ["Anthrax spores can be disposed of easily after they are dispersed.", "Only a minority of cells survive development after differentiation into stress-resistant spores.", "New drugs for tuberculosis often do not penetrate the necrotic portion of a tuberculosis lesion in high concentrations.", "In mice, P. chabaudi parasites are able to proliferate faster early in infection when inoculated at lower numbers than when inoculated at high numbers.", "In domesticated populations of Saccharomyces cerevisiae, whole chromosome aneuploidy is very uncommon.", "The center of the granuloma in an immune cell induces a pro-inflammatory immune response.", "High levels of CRP reduces the risk of exacerbations in chronic obstructive pulmonary disease (COPD).", "Helminths interfere with immune system control of macrophages activated by IL-4 favor Mycobacterium tuberculosis replication.", "All hematopoietic stem cells segregate their chromosomes randomly.", "Enhanced early production of inflammatory chemokines improves viral control in the lung."], "hard_negative": "Anthrax spores can be disposed of easily after they are dispersed."}
{"query_id": "118", "query_text": "Antibiotic induced alterations in the gut microbiome reduce resistance against Clostridium difficile", "negative": "Immune complex triggered cell death leads to extracellular release of neutrophil protein HMGB1.", "negatives": ["Immune complex triggered cell death leads to extracellular release of neutrophil protein HMGB1.", "Discrimination between the initiator and elongation tRNAs depends on the translation initiation factor IF3.", "Cellular aging closely links to an older appearance.", "Deleting Raptor reduces G-CSF levels.", "Smc5/6 engagment drives the activation of SUMO E3 ligase Mms21 by ATP-dependent remolding.", "Diabetic patients with acute coronary syndrome experience increased short-term and long-term risk for bleeding events.", "Deletion of \u03b1v\u03b28 does not result in a spontaneous inflammatory phenotype.", "Commelina yellow mottle virus' (ComYMV) genome consists of 7489 baise pairs.", "AIRE is expressed in some skin tumors.", "Thigh-length graduated compression stockings (GCS) did not reduce deep vein thrombosis in patients admitted to hospital who are immobile because of acute stroke."], "hard_negatives": ["Antibiotic induced alterations in the gut microbiome reduce resistance against Clostridium difficile", "Helminths interfere with immune system control of macrophages activated by IL-4 favor Mycobacterium tuberculosis replication.", "Ethanol stress decreases the expression of IBP in bacteria.", "New drugs for tuberculosis often do not penetrate the necrotic portion of a tuberculosis lesion in high concentrations.", "Deamination of cytidine to uridine on the minus strand of viral DNA results in catastrophic G-to-A mutations in the viral genome.", "Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have a dramatic impact in reducing malaria transmission.", "Active H. pylori urease has a polymeric structure that compromises two subunits, UreA and UreB.", "Enhanced early production of inflammatory chemokines improves viral control in the lung.", "Mercaptopurine is anabolized into the inactive methylmercaptopurine by thiopurine methyltrasnferase (TPMT).", "Arginine 90 in p150n is important for interaction with EB1."], "hard_negative": "Antibiotic induced alterations in the gut microbiome reduce resistance against Clostridium difficile"}
{"query_id": "124", "query_text": "Antiretroviral therapy reduces rates of tuberculosis across a broad range of CD4 strata.", "negative": "Hypothalamic glutamate neurotransmission is crucial to energy balance.", "negatives": ["Hypothalamic glutamate neurotransmission is crucial to energy balance.", "Crosstalk between dendritic cells (DCs) and innate lymphoid cells (ILCs) is important in the regulation of intestinal homeostasis.", "The risk of male prisoners harming themselves is ten times that of female prisoners.", "Combination nicotine replacement therapies with varenicline or bupropion lead to significantly higher long-term abstinence rates at 52 weeks than varenicline monotherapy.", "Arginine 90 in p150n is important for interaction with EB1.", "All hematopoietic stem cells segregate their chromosomes randomly.", "Varenicline monotherapy is more effective after 12 weeks of treatment compared to combination nicotine replacement therapies with varenicline or bupropion.", "Aspirin inhibits the production of PGE2.", "Polymeal nutrition reduces cardiovascular mortality.", "Taxation of sugar-sweetened beverages had no effect on the incidence rate of type II diabetes in India."], "hard_negatives": ["Antiretroviral therapy reduces rates of tuberculosis across a broad range of CD4 strata.", "New drugs for tuberculosis often do not penetrate the necrotic portion of a tuberculosis lesion in high concentrations.", "Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have a dramatic impact in reducing malaria transmission.", "Helminths interfere with immune system control of macrophages activated by IL-4 favor Mycobacterium tuberculosis replication.", "Combination nicotine replacement therapies with varenicline or bupropion lead to significantly higher long-term abstinence rates at 52 weeks than varenicline monotherapy.", "Hypoglycemia increases the risk of dementia.", "Deletion of \u03b1v\u03b28 does not result in a spontaneous inflammatory phenotype.", "Mice that lack Interferon-\u03b3 or its receptor exhibit high resistance to experimental autoimmune myocarditis.", "Varenicline monotherapy is more effective after 12 weeks of treatment compared to combination nicotine replacement therapies with varenicline or bupropion.", "The benefits of colchicine were achieved with effective widespread use of secondary prevention strategies such as high-dose statins."], "hard_negative": "Antiretroviral therapy reduces rates of tuberculosis across a broad range of CD4 strata."}
{"query_id": "127", "query_text": "Arginine 90 in p150n is important for interaction with EB1.", "negative": "Incidence of heart failure decreased by 10% in women since 1979.", "negatives": ["Incidence of heart failure decreased by 10% in women since 1979.", "UCB T cells reduce TCR diversity after transplantation.", "In young and middle-aged adults, current or remote uses of ADHD medications do not increase the risk of serious cardiovascular events.", "Anthrax spores can be disposed of easily after they are dispersed.", "Active H. pylori urease has a polymeric structure that compromises two subunits, UreA and UreB.", "Ethanol stress decreases the expression of IBP in bacteria.", "Deletion of \u03b1v\u03b28 does not result in a spontaneous inflammatory phenotype.", "Most termination events in Okazaki fragments are sequence specific.", "Auditory entrainment is strengthened when people see congruent visual and auditory information.", "Rapid up-regulation and higher basal expression of interferon-induced genes reduce survival of granule cell neurons that are infected by West Nile virus."], "hard_negatives": ["Arginine 90 in p150n is important for interaction with EB1.", "The ureABIEFGH gene cluster is induced by nickel (II) ion.", "N348I mutations cause resistance to zidovudine (AZT).", "Mutations in G-Beta protein GNB2 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.", "Ubiquitin ligase UBC13 generates a K63-linked polyubiquitin moiety at PCNA K164.", "NR5A2 is important in development of endometrial tissues.", "p16INK4A accumulation is  linked to an abnormal wound response caused by the microinvasive step of advanced Oral Potentially Malignant Lesions (OPMLs).", "IRG1 has antiviral effects against neurotropic viruses.", "APOE4 expression in iPSC-derived neurons increases AlphaBeta production and tau phosphorylation, delaying GABA neuron degeneration.", "The extracellular domain of TMEM27 is cleaved in human beta cells."], "hard_negative": "Arginine 90 in p150n is important for interaction with EB1."}
{"query_id": "128", "query_text": "Arterioles have a larger lumen diameter than venules.", "negative": "Functional consequences of genomic alterations due to Myelodysplastic syndrome (MDS) are poorly understood due to the lack of an animal model.", "negatives": ["Functional consequences of genomic alterations due to Myelodysplastic syndrome (MDS) are poorly understood due to the lack of an animal model.", "MicroRNA is involved in the regulation of Neural Stem Cell (NSC) differentiation and proliferation dynamic homeostasis", "In mice, P. chabaudi parasites are able to proliferate faster early in infection when inoculated at lower numbers than when inoculated at high numbers.", "Primary pro-inflammatory cytokines induce secondary pro- and anti-inflammatory mediators.", "The treatment of cancer patients with co-IR blockade does not cause any adverse autoimmune events.", "Ly49Q directs the organization of neutrophil migration to inflammation sites by regulating membrane raft functions.", "Non-invasive ventilation use should be decreased if there is inadequate response to conventional treatment.", "mTORC2 regulates intracellular cysteine levels through xCT inhibition.", "Pyridostatin destabilizes the G - quadruplex in the telomeric region.", "Lymphadenopathy is observed in knockin mouse lacking the SHP-2 MAPK pathway."], "hard_negatives": ["Arterioles have a larger lumen diameter than venules.", "Venules have a larger lumen diameter than arterioles.", "Venules have a thinner or absent smooth layer compared to arterioles.", "Flexible molecules experience greater steric hindrance in the tumor microenviroment than rigid molecules.", "Podocytes are motile and migrate in the presence of injury.", "Pyridostatin destabilizes the G - quadruplex in the telomeric region.", "PDPN promotes efficient motility along stromal surfaces by activating the C-type lectin receptor to rearrange the actin cytoskeleton in dendritic cells.", "Nanoparticles can be targeted against specific cell types by incorporating aptamers into lipid nanoparticles.", "The arm density of TatAd complexes is due to structural rearrangements within Class1 TatAd complexes such as the 'charge zipper mechanism'.", "0-dimensional biomaterials show inductive properties."], "hard_negative": "Arterioles have a larger lumen diameter than venules."}
{"query_id": "129", "query_text": "Articles published in open access format are less likely to be cited than traditional journals.", "negative": "Cell autonomous sex determination in somatic cells occurs in Passeriformes.", "negatives": ["Cell autonomous sex determination in somatic cells occurs in Passeriformes.", "Chenodeosycholic acid treatment reduces whole-body energy expenditure.", "TNFAIP3 is a tumor suppressor in glioblastoma.", "Upregulation of mosGCTL-1 is induced upon infection with West Nile virus.", "Immune complex triggered cell death leads to extracellular release of neutrophil protein HMGB1.", "The extracellular domain of TMEM27 is cleaved in human beta cells.", "Less than 10% of the gabonese children with Schimmelpenning-Feuerstein-Mims syndrome (SFM) had a plasma lactate of more than 5mmol/L.", "Chenodeosycholic acid treatment increases whole-body energy expenditure.", "The arm density of TatAd complexes is due to structural rearrangements within Class1 TatAd complexes such as the 'charge zipper mechanism'.", "TNFAIP3 is a tumor suppressor in glioblastoma."], "hard_negatives": ["Articles published in open access format are less likely to be cited than traditional journals.", "Articles published in open access format are more likely to be cited than traditional journals.", "The amount of publicly available DNA data doubles every 10 years.", "Teaching hospitals do not provide better care than non-teaching hospitals.", "De novo assembly of sequence data has more specific contigs than unassembled sequence data.", "Integrating classroom-based collaborative learning with Web-based collaborative learning leads to subpar class performance", "Epidemiological disease burden from noncommunicable diseases is more prevalent in low economic settings.", "Patients in stable partnerships have a faster progression from HIV to AIDS.", "The availability of safe places to study is effective at decreasing homelessness.", "The availability of safe places to study is not effective at decreasing homelessness."], "hard_negative": "Articles published in open access format are less likely to be cited than traditional journals."}
{"query_id": "130", "query_text": "Articles published in open access format are more likely to be cited than traditional journals.", "negative": "Obesity decreases life quality.", "negatives": ["Obesity decreases life quality.", "The ureABIEFGH gene cluster encodes urease maturation proteins : UreD/UreH, UreE, UreF, and UreG.", "Mercaptopurine is anabolized into the inactive methylmercaptopurine by thiopurine methyltrasnferase (TPMT).", "The composition of myosin-II isoform switches from the polarizable B isoform to the more homogenous A isoform during hematopoietic differentiation.", "Hypothalamic glutamate neurotransmission is crucial to energy balance.", "Activator-inhibitor pairs are provided dorsally by Admpchordin.", "Commelina yellow mottle virus' (ComYMV) genome consists of 7489 baise pairs.", "Lymphadenopathy is observed in knockin mouse lacking the SHP-2 MAPK pathway.", "The ureABIEFGH gene cluster encodes urease maturation proteins : UreD/UreH, UreE, UreF, and UreG.", "Macropinocytosis contributes to a cell's supply of amino acids via the intracellular uptake of protein."], "hard_negatives": ["Articles published in open access format are more likely to be cited than traditional journals.", "Articles published in open access format are less likely to be cited than traditional journals.", "The amount of publicly available DNA data doubles every 10 years.", "Integrating classroom-based collaborative learning with Web-based collaborative learning leads to subpar class performance", "De novo assembly of sequence data has more specific contigs than unassembled sequence data.", "Teaching hospitals do not provide better care than non-teaching hospitals.", "Epidemiological disease burden from noncommunicable diseases is more prevalent in low economic settings.", "Patients in stable partnerships have a faster progression from HIV to AIDS.", "The availability of safe places to study is effective at decreasing homelessness.", "The availability of safe places to study is not effective at decreasing homelessness."], "hard_negative": "Articles published in open access format are more likely to be cited than traditional journals."}
{"query_id": "132", "query_text": "Aspirin inhibits the production of PGE2.", "negative": "NFAT4 activation requires IP3R-mediated Ca2+ mobilization.", "negatives": ["NFAT4 activation requires IP3R-mediated Ca2+ mobilization.", "Bone marrow cells contribute to adult macrophage compartments.", "Statins increase blood cholesterol.", "The loss of the TET protein functions may have dire biological consequences, such as myeloid cancers.", "Synaptic activity enhances local release of brain derived neurotrophic factor from postsynaptic dendrites.", "MicroRNA is involved in the regulation of Neural Stem Cell (NSC) differentiation and proliferation dynamic homeostasis", "The combination of H3K4me3 and H3K79me2 is found in quiescent hair follicle stem cells.", "Ultrasound guidance significantly raises the number of traumatic procedures when attempting needle insertion.", "Pyridostatin destabilizes the G - quadruplex in the telomeric region.", "Golli-deficient T-cells prefer to differentiate into an anergic phenotype in the adaptive immune response when there are increased levels of Ca2+ in the cytosol."], "hard_negatives": ["Aspirin inhibits the production of PGE2.", "PGE 2 promotes intestinal tumor growth by altering the expression of tumor suppressing and DNA repair genes.", "PKG-la plays an essential role in expression of pain hypersensitivity in PGK-la knockout mice.", "Sildenafil improves erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.", "Alizarin forms hydrogen bonds with residues involved in PGAM1 substrate binding.", "Activation of PPM1D suppresses p53 function.", "PD-1 triggering on monocytes reduces IL-10 production by monocytes.", "Arginine 90 in p150n is important for interaction with EB1.", "Ethanol stress decreases the expression of IBP in bacteria.", "Mutant mice lacking SVCT2 have greatly increased ascorbic acid levels in both brain and adrenals."], "hard_negative": "Aspirin inhibits the production of PGE2."}
{"query_id": "133", "query_text": "Assembly of invadopodia is triggered by focal generation of phosphatidylinositol-3,4-biphosphate and the activation of the nonreceptor tyrosine kinase Src.", "negative": "Low expression of miR7a exerts a biological function in testis.", "negatives": ["Low expression of miR7a exerts a biological function in testis.", "There is an inverse relationship between hip fractures and statin use.", "Input from  mental and physical health care professionals is effective at decreasing homelessness.", "Venules have a thinner or absent smooth layer compared to arterioles.", "Integrating classroom-based collaborative learning with Web-based collaborative learning leads to subpar class performance", "Reduced responsiveness to interleukin-2 in regulatory T cells is associated with greater resistance to autoimmune diseases such as Type 1 Diabetes.", "Low nucleosome occupancy correlates with low methylation levels across species.", "Pseudogene PTENP1 regulates the expression of PTEN by functioning as an miRNA decoy.", "A deficiency of vitamin B12 increases blood levels of homocysteine.", "Cells undergoing methionine restriction may activate miRNAs."], "hard_negatives": ["Assembly of invadopodia is triggered by focal generation of phosphatidylinositol-3,4-biphosphate and the activation of the nonreceptor tyrosine kinase Src.", "Activator-inhibitor pairs are provided dorsally by Admpchordin.", "The single flash-evoked ERG b-wave is generated by activity of ON-bipolar cells.", "PDPN promotes efficient motility along stromal surfaces by activating the C-type lectin receptor to rearrange the actin cytoskeleton in dendritic cells.", "The sliding activity of kinesin-8 protein Kip3 promotes bipolar spindle assembly.", "Podocytes are motile and migrate in the presence of injury.", "Mitochondria are uninvolved in apoptosis.", "During the primary early antibody response activated B cells migrate toward the inner-and outer paracortical areas where oxysterol accumulation is generated by stromal cells.", "Synaptic activity enhances local release of brain derived neurotrophic factor from postsynaptic dendrites.", "ITAM phosphorylation prevents the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR)."], "hard_negative": "Assembly of invadopodia is triggered by focal generation of phosphatidylinositol-3,4-biphosphate and the activation of the nonreceptor tyrosine kinase Src."}
{"query_id": "137", "query_text": "Asymptomatic visual impairment screening in elderly populations does not lead to improved vision.", "negative": "Headaches are not correlated with cognitive impairment.", "negatives": ["Headaches are not correlated with cognitive impairment.", "Cytosolic proteins bind to iron-responsive elements on mRNAs coding for DMT1. Cytosolic proteins bind to iron-responsive elements on mRNAs coding for proteins involved in iron uptake.", "Hyperfibrinogenemia decreases rates of femoropopliteal bypass thrombosis.", "Microarray results from culture-amplified mixtures of serotypes correlate poorly with microarray results from uncultured mixtures.", "PPAR-RXRs can be activated by PPAR ligands.", "PPAR-RXRs can be activated by PPAR ligands.", "ITAM phosphorylation prevents the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).", "High-sensitivity cardiac troponin T (HSCT-T) dosage may not be diagnostic if the onset of symptoms occurs less than 3 hours before acute myocardial injury (AMI).", "Silencing of Bcl2 is important for the maintenance and progression of tumors.", "Pyridostatin destabilizes the G - quadruplex in the telomeric region."], "hard_negatives": ["Asymptomatic visual impairment screening in elderly populations does not lead to improved vision.", "Headaches are not correlated with cognitive impairment.", "In young and middle-aged adults, current or remote uses of ADHD medications do not increase the risk of serious cardiovascular events.", "Hypoglycemia increases the risk of dementia.", "Auditory entrainment is strengthened when people see congruent visual and auditory information.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have increased risk for dementia.", "Cataract and trachoma are the primary cause of blindness in Southern Sudan.", "Hypertension is frequently observed in type 1 diabetes patients.", "Insomnia can be effectively treated with cognitive behavioral therapy.", "CRP is not predictive of postoperative mortality following Coronary Artery Bypass Graft (CABG) surgery."], "hard_negative": "Asymptomatic visual impairment screening in elderly populations does not lead to improved vision."}
{"query_id": "141", "query_text": "Auditory entrainment is strengthened when people see congruent visual and auditory information.", "negative": "The single flash-evoked ERG b-wave is generated by activity of ON-bipolar cells.", "negatives": ["The single flash-evoked ERG b-wave is generated by activity of ON-bipolar cells.", "Flexible molecules experience greater steric hindrance in the tumor microenviroment than rigid molecules.", "Rapid up-regulation and higher basal expression of interferon-induced genes reduce survival of granule cell neurons that are infected by West Nile virus.", "T regulatory cells (tTregs) lacking \u03b1v\u03b28 are more adept at suppressing pathogenic T-cell responses during active inflammation.", "All hematopoietic stem cells segregate their chromosomes randomly.", "Ivermectin is used to treat onchocerciasis.", "Epidemiological disease burden from noncommunicable diseases is more prevalent in low economic settings.", "New drugs for tuberculosis often do not penetrate the necrotic portion of a tuberculosis lesion in high concentrations.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have increased risk for dementia.", "Obesity decreases life quality."], "hard_negatives": ["Auditory entrainment is strengthened when people see congruent visual and auditory information.", "Headaches are not correlated with cognitive impairment.", "Asymptomatic visual impairment screening in elderly populations does not lead to improved vision.", "Hypothalamic glutamate neurotransmission is crucial to energy balance.", "Ultrasound guidance significantly raises the number of traumatic procedures when attempting needle insertion.", "Activator-inhibitor pairs are provided dorsally by Admpchordin.", "Exposure to fine particulate air pollution is relate to anxiety prevalence.", "Crosstalk between dendritic cells (DCs) and innate lymphoid cells (ILCs) is important in the regulation of intestinal homeostasis.", "Insomnia can be effectively treated with cognitive behavioral therapy.", "Synaptic activity enhances local release of brain derived neurotrophic factor from postsynaptic dendrites."], "hard_negative": "Auditory entrainment is strengthened when people see congruent visual and auditory information."}
{"query_id": "142", "query_text": "Autologous transplantation of mesenchymal stem cells causes a higher rate of opportunistic infections than induction therapy with anti-interleukin-2 receptor antibodies.", "negative": "Bone marrow cells contribute to adult macrophage compartments.", "negatives": ["Bone marrow cells contribute to adult macrophage compartments.", "Pyridostatin destabilizes the G - quadruplex in the telomeric region.", "Ubiquitin ligase UBC13 generates a K63-linked polyubiquitin moiety at PCNA K164.", "Only a minority of cells survive development after differentiation into stress-resistant spores.", "Cellular aging closely links to an older appearance.", "PD-1 triggering on monocytes reduces IL-10 production by monocytes.", "Combination nicotine replacement therapies with varenicline or bupropion lead to significantly higher long-term abstinence rates at 52 weeks than varenicline monotherapy.", "Ribosomopathies have a low degree of cell and tissue specific pathology.", "Lupus-prone mice infected with curliproducing bacteria have higher autoantibody titers compared to controls.", "mTORC2 regulates intracellular cysteine levels through xCT inhibition."], "hard_negatives": ["Autologous transplantation of mesenchymal stem cells causes a higher rate of opportunistic infections than induction therapy with anti-interleukin-2 receptor antibodies.", "Autologous transplantation of mesenchymal stem cells causes fewer opportunistic infections than induction therapy with anti-interleukin-2 receptor antibodies.", "Autologous transplantation of mesenchymal stem cells has lower rates of rejection than induction therapy with anti-interleukin-2 receptor antibodies.", "Increased vessel density along with a reduction in fibrosis decreases the efficacy of chemotherapy treatments.", "Immune responses result in the development of inflammatory Th17 cells and anti-inflammatory iTregs.", "Epigenetic modulating agents (EMAs) modulate antitumor immune response in a cancer model system.", "Golli-deficient T-cells prefer to differentiate into an anergic phenotype in the adaptive immune response when there are increased levels of Ca2+ in the cytosol.", "Homozygous deletion of murine Sbds gene from osterix-expressing mesenchymal stem and progenitor cells (MPCs) prevents oxidative stress.", "Reduced responsiveness to interleukin-2 in regulatory T cells is associated with greater resistance to autoimmune diseases such as Type 1 Diabetes.", "The treatment of cancer patients with co-IR blockade precipitates adverse autoimmune events."], "hard_negative": "Autologous transplantation of mesenchymal stem cells causes a higher rate of opportunistic infections than induction therapy with anti-interleukin-2 receptor antibodies."}
{"query_id": "143", "query_text": "Autologous transplantation of mesenchymal stem cells causes fewer opportunistic infections than induction therapy with anti-interleukin-2 receptor antibodies.", "negative": "Proteins synthesized at the growth cone are ubiquitinated at a higher rate than proteins from the cell body.", "negatives": ["Proteins synthesized at the growth cone are ubiquitinated at a higher rate than proteins from the cell body.", "Golli-deficient T-cells prefer to differentiate into an anergic phenotype in the adaptive immune response when there are increased levels of Ca2+ in the cytosol.", "In young and middle-aged adults, current or remote uses of ADHD medications do not increase the risk of serious cardiovascular events.", "Basophils counteract disease development in patients with systemic lupus erythematosus (SLE).", "Activator-inhibitor pairs are provided dorsally by Admpchordin.", "Rapid phosphotransfer rates govern fidelity in two component systems", "A high microerythrocyte count raises vulnerability to severe anemia in homozygous alpha (+)- thalassemia trait subjects.", "Primary pro-inflammatory cytokines induce secondary pro- and anti-inflammatory mediators.", "Macrolides have no protective effect against myocardial infarction.", "PGE 2 promotes intestinal tumor growth by altering the expression of tumor suppressing and DNA repair genes."], "hard_negatives": ["Autologous transplantation of mesenchymal stem cells causes fewer opportunistic infections than induction therapy with anti-interleukin-2 receptor antibodies.", "Autologous transplantation of mesenchymal stem cells has lower rates of rejection than induction therapy with anti-interleukin-2 receptor antibodies.", "Autologous transplantation of mesenchymal stem cells causes a higher rate of opportunistic infections than induction therapy with anti-interleukin-2 receptor antibodies.", "Reduced responsiveness to interleukin-2 in regulatory T cells is associated with greater resistance to autoimmune diseases such as Type 1 Diabetes.", "Homozygous deletion of murine Sbds gene from osterix-expressing mesenchymal stem and progenitor cells (MPCs) prevents oxidative stress.", "Epigenetic modulating agents (EMAs) modulate antitumor immune response in a cancer model system.", "Golli-deficient T-cells prefer to differentiate into an anergic phenotype in the adaptive immune response when there are increased levels of Ca2+ in the cytosol.", "Mice that lack Interferon-\u03b3 or its receptor exhibit high resistance to experimental autoimmune myocarditis.", "Stroke patients with prior use of direct oral anticoagulants have a lower risk of in-hospital mortality than stroke patients with prior use of warfarin.", "The treatment of cancer patients with co-IR blockade precipitates adverse autoimmune events."], "hard_negative": "Autologous transplantation of mesenchymal stem cells causes fewer opportunistic infections than induction therapy with anti-interleukin-2 receptor antibodies."}
{"query_id": "146", "query_text": "Autologous transplantation of mesenchymal stem cells has lower rates of rejection than induction therapy with anti-interleukin-2 receptor antibodies.", "negative": "The risk of male prisoners harming themselves is ten times that of female prisoners.", "negatives": ["The risk of male prisoners harming themselves is ten times that of female prisoners.", "A total of 1,000 people in the UK are asymptomatic carriers of vCJD infection.", "cSMAC formation enhances weak ligand signalling.", "T regulatory cells (tTregs) lacking \u03b1v\u03b28 are more adept at suppressing pathogenic T-cell responses during active inflammation.", "Activator-inhibitor pairs are provided dorsally by Admpchordin.", "Most termination events in Okazaki fragments are sequence specific.", "Low expression of miR7a does represses target genes and exerts a biological function in ovaries.", "Up-regulation of the p53 pathway and related molecular events casues cancer resistance and results in a significantly shortened lifespan marked by senescent cells and accelerated organismal aging.", "The US health care system can save up to $750 million if 7% of patients waiting for kidney transplants participate in the optimized national kidney paired donation program.", "Chronic aerobic exercise alters endothelial function, improving vasodilating mechanisms mediated by NO."], "hard_negatives": ["Autologous transplantation of mesenchymal stem cells has lower rates of rejection than induction therapy with anti-interleukin-2 receptor antibodies.", "Autologous transplantation of mesenchymal stem cells causes fewer opportunistic infections than induction therapy with anti-interleukin-2 receptor antibodies.", "Autologous transplantation of mesenchymal stem cells causes a higher rate of opportunistic infections than induction therapy with anti-interleukin-2 receptor antibodies.", "Reduced responsiveness to interleukin-2 in regulatory T cells is associated with greater resistance to autoimmune diseases such as Type 1 Diabetes.", "UCB T cells reduce TCR diversity after transplantation.", "The US health care system can save up to $750 million if 7% of patients waiting for kidney transplants participate in the optimized national kidney paired donation program.", "Golli-deficient T-cells prefer to differentiate into an anergic phenotype in the adaptive immune response when there are increased levels of Ca2+ in the cytosol.", "Homozygous deletion of murine Sbds gene from osterix-expressing mesenchymal stem and progenitor cells (MPCs) prevents oxidative stress.", "UCB T cells maintain high TCR diversity after transplantation.", "Epigenetic modulating agents (EMAs) modulate antitumor immune response in a cancer model system."], "hard_negative": "Autologous transplantation of mesenchymal stem cells has lower rates of rejection than induction therapy with anti-interleukin-2 receptor antibodies."}
{"query_id": "148", "query_text": "Autophagy declines in aged organisms.", "negative": "Glycolysis is one of the primary glycometabolic pathways in cells.", "negatives": ["Glycolysis is one of the primary glycometabolic pathways in cells.", "The sliding activity of kinesin-8 protein Kip3 promotes bipolar spindle assembly.", "Radioiodine treatment of non-toxic multinodular goitre reduces thyroid volume.", "ALDH1 expression is associated with better breast cancer outcomes.", "Errors in peripheral IV drug administration are most common during bolus administration and multiple-step medicine preparations.", "Glycolysis is one of the primary glycometabolic pathways in cells.", "Antibiotic induced alterations in the gut microbiome reduce resistance against Clostridium difficile", "Cell autonomous sex determination in somatic cells does not occur in Galliformes.", "Cell autonomous sex determination in somatic cells occurs in Passeriformes.", "The DdrB protein from Deinococcus radiodurans is an alternative SSB."], "hard_negatives": ["Autophagy declines in aged organisms.", "Cellular aging closely links to an older appearance.", "Hypoglycemia increases the risk of dementia.", "Ethanol stress decreases the expression of IBP in bacteria.", "Obesity decreases life quality.", "Low nucleosome occupancy correlates with low methylation levels across species.", "Epidemiological disease burden from noncommunicable diseases is more prevalent in low economic settings.", "Modifying the epigenome in the brain affects the normal human aging process by affecting certain genes related to neurogenesis.", "Obesity is determined solely by environmental factors.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have increased risk for dementia."], "hard_negative": "Autophagy declines in aged organisms."}
{"query_id": "163", "query_text": "Bariatric surgery has a positive impact on mental health.", "negative": "Epigenetic modulating agents (EMAs) modulate antitumor immune response in a cancer model system.", "negatives": ["Epigenetic modulating agents (EMAs) modulate antitumor immune response in a cancer model system.", "The myocardial lineage develops from cardiac progenitors of mesodermal origin.", "NR5A2 is important in development of endometrial tissues.", "The center of the granuloma in an immune cell induces a pro-inflammatory immune response.", "Carriers of the alcohol aldehyde dehydrogenase deficiency mutation drink less that non-carries.", "Arginine 90 in p150n is important for interaction with EB1.", "Therapeutic use of the drug Dapsone to treat pyoderma gangrenous is based on anecdotal evidence.", "Bone marrow cells contribute to adult macrophage compartments.", "The treatment of cancer patients with co-IR blockade precipitates adverse autoimmune events.", "Glycolysis is one of the primary glycometabolic pathways in cells."], "hard_negatives": ["Bariatric surgery has a positive impact on mental health.", "Teaching hospitals do not provide better care than non-teaching hospitals.", "Functional consequences of genomic alterations due to Myelodysplastic syndrome (MDS) are poorly understood due to the lack of an animal model.", "There is an inverse relationship between hip fractures and statin use.", "Input from  mental and physical health care professionals is effective at decreasing homelessness.", "Thigh-length graduated compression stockings (GCS) did not reduce deep vein thrombosis in patients admitted to hospital who are immobile because of acute stroke.", "Vitamin D deficiency effects the term of delivery.", "Ultrasound guidance significantly raises the number of traumatic procedures when attempting needle insertion.", "CRP is not predictive of postoperative mortality following Coronary Artery Bypass Graft (CABG) surgery.", "Healthcare delivery efficiency in crowded delivery centers is impaired by improving structural, logistical, and interpersonal elements."], "hard_negative": "Bariatric surgery has a positive impact on mental health."}
{"query_id": "171", "query_text": "Basophils counteract disease development in patients with systemic lupus erythematosus (SLE).", "negative": "AMP-activated protein kinase (AMPK) activation increases inflammation-related fibrosis in the lungs.", "negatives": ["AMP-activated protein kinase (AMPK) activation increases inflammation-related fibrosis in the lungs.", "Cell autonomous sex determination in somatic cells occurs in Passeriformes.", "Deletion of \u03b1v\u03b28 does not result in a spontaneous inflammatory phenotype.", "CRP is not predictive of postoperative mortality following Coronary Artery Bypass Graft (CABG) surgery.", "Localization of PIN1 in the Arabidopsis embryo does not require VPS9a", "Hyperfibrinogenemia decreases rates of femoropopliteal bypass thrombosis.", "Macropinocytosis contributes to a cell's supply of amino acids via the intracellular uptake of protein.", "Venules have a larger lumen diameter than arterioles.", "PD-1 triggering on monocytes reduces IL-10 production by monocytes.", "Leuko-reduced blood reduces infectious complications in red blood cell transfusion."], "hard_negatives": ["Basophils counteract disease development in patients with systemic lupus erythematosus (SLE).", "Helminths interfere with immune system control of macrophages activated by IL-4 favor Mycobacterium tuberculosis replication.", "Neutrophil extracellular traps (NETs) are released by ANCA-stimulated neutrophils.", "Mice that lack Interferon-\u03b3 or its receptor exhibit high resistance to experimental autoimmune myocarditis.", "Lupus-prone mice infected with curliproducing bacteria have higher autoantibody titers compared to controls.", "Increased vessel density along with a reduction in fibrosis decreases the efficacy of chemotherapy treatments.", "Macrolides protect against myocardial infarction.", "Leuko-reduced blood reduces infectious complications in red blood cell transfusion.", "LDL cholesterol has no involvement in the development of cardiovascular disease.", "Macrolides have no protective effect against myocardial infarction."], "hard_negative": "Basophils counteract disease development in patients with systemic lupus erythematosus (SLE)."}
{"query_id": "179", "query_text": "Birth-weight is positively associated with breast cancer.", "negative": "Combining phosphatidylinositide 3-kinase and MEK 1/2 inhibitors is effective at treating KRAS mutant tumors.", "negatives": ["Combining phosphatidylinositide 3-kinase and MEK 1/2 inhibitors is effective at treating KRAS mutant tumors.", "Activator-inhibitor pairs are provided dorsally by Admpchordin.", "Errors in peripheral IV drug administration are most common during bolus administration and multiple-step medicine preparations.", "Breast cancer development is determined exclusively by genetic factors.", "UCB T cells maintain high TCR diversity after transplantation.", "The YAP1 and TEAD complex tanslocates into the nucleus where it interacts with transcription factors and DNA-binding proteins that modulate target gene transcription.", "Statins decrease blood cholesterol.", "During the primary early antibody response activated B cells migrate toward the inner-and outer paracortical areas where oxysterol accumulation is generated by stromal cells.", "Neutrophil extracellular traps (NETs) are released by ANCA-stimulated neutrophils.", "Glycolysis is one of the primary glycometabolic pathways in cells."], "hard_negatives": ["Birth-weight is positively associated with breast cancer.", "Women with a higher birth weight are more likely to develop breast cancer later in life.", "Breast cancer development is determined exclusively by genetic factors.", "5% of perinatal mortality is due to low birth weight.", "The risk of breast cancer among parous women increases with placental weight of pregnancies, and this association is strongest for premenopausal breast cancer.", "Vitamin D deficiency is unrelated to birth weight.", "Incidence rates of cervical cancer have increased due to nationwide screening programs based primarily on cytology to detect uterine cervical cancer.", "Incidence rates of cervical cancer have decreased.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have increased risk for dementia.", "CHEK2 is not associated with breast cancer."], "hard_negative": "Birth-weight is positively associated with breast cancer."}
{"query_id": "180", "query_text": "Blocking the interaction between TDP-43 and respiratory complex I proteins ND3 and ND6 leads to increased TDP-43-induced neuronal loss.", "negative": "Localization of PIN1 in the roots of Arabidopsis does not require VPS9a", "negatives": ["Localization of PIN1 in the roots of Arabidopsis does not require VPS9a", "Mutations in G-Beta protein GNB2 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.", "Flexible molecules experience greater steric hindrance in the tumor microenviroment than rigid molecules.", "Sildenafil improves erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.", "Histone demethylase recruitment and a transient decrease in histone methylation is necessary for ligand-dependent induction of transcription by nuclear receptors.", "A high microerythrocyte count raises vulnerability to severe anemia in homozygous alpha (+)- thalassemia trait subjects.", "PPAR-RXRs are inhibited by PPAR ligands.", "Anthrax spores can be disposed of easily after they are dispersed.", "PDPN promotes efficient motility along stromal surfaces by activating the C-type lectin receptor to rearrange the actin cytoskeleton in dendritic cells.", "NFAT4 activation requires IP3R-mediated Ca2+ mobilization."], "hard_negatives": ["Blocking the interaction between TDP-43 and respiratory complex I proteins ND3 and ND6 leads to increased TDP-43-induced neuronal loss.", "ITAM phosphorylation prevents the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).", "Reduced responsiveness to interleukin-2 in regulatory T cells is associated with greater resistance to autoimmune diseases such as Type 1 Diabetes.", "Ly49Q directs the organization of neutrophil migration to inflammation sites by regulating membrane raft functions.", "CX3CR1 on the Th2 cells suppresses airway inflammation.", "PD-1 triggering on monocytes reduces IL-10 production by monocytes.", "CX3CR1 on the Th2 cells promotes airway inflammation.", "NF2 (Merlin) causes phosphorylation and subsequent cytoplasmic sequestration of YAP in Drosophila by activating LATS1/2 kinases.", "Activation of PPM1D suppresses p53 function.", "S-nitrosylated GAPDH physiologically transnitrosylates histone deacetylases."], "hard_negative": "Blocking the interaction between TDP-43 and respiratory complex I proteins ND3 and ND6 leads to increased TDP-43-induced neuronal loss."}
{"query_id": "183", "query_text": "Bone marrow cells contribute to adult macrophage compartments.", "negative": "ITAM phosphorylation prevents the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).", "negatives": ["ITAM phosphorylation prevents the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).", "The risk of male prisoners harming themselves is ten times that of female prisoners.", "Localization of PIN1 in the roots of Arabidopsis does not require VPS9a", "The sliding activity of kinesin-8 protein Kip3 promotes bipolar spindle assembly.", "Carriers of the alcohol aldehyde dehydrogenase deficiency mutation drink less that non-carries.", "Ly6C hi monocytes have a lower inflammatory capacity compared to their Ly6C lo counterparts.", "CR is associated with higher methylation age.", "Epigenetic modulating agents (EMAs) modulate antitumor immune response in a cancer model system.", "Mitochondria are uninvolved in apoptosis.", "CRP is not predictive of postoperative mortality following Coronary Artery Bypass Graft (CABG) surgery."], "hard_negatives": ["Bone marrow cells contribute to adult macrophage compartments.", "The extracellular domain of TMEM27 is cleaved in human beta cells.", "Transplanted human glial cells can differentiate within the host animal.", "Macropinocytosis contributes to a cell's supply of amino acids via the intracellular uptake of protein.", "The myocardial lineage develops from cardiac progenitors of mesodermal origin.", "Transplanted human glial progenitor cells are incapable of forming a neural network with host animals' neurons.", "Glycolysis is one of the primary glycometabolic pathways in cells.", "The deregulated and prolonged activation of monocytes has deleterious effects in inflammatory diseases.", "In adult tissue, most T cells are memory T cells.", "Ly6C hi monocytes have a lower inflammatory capacity than Ly6C lo monocytes."], "hard_negative": "Bone marrow cells contribute to adult macrophage compartments."}
{"query_id": "185", "query_text": "Breast cancer development is determined exclusively by genetic factors.", "negative": "Alizarin forms hydrogen bonds with residues involved in PGAM1 substrate binding.", "negatives": ["Alizarin forms hydrogen bonds with residues involved in PGAM1 substrate binding.", "Stroke patients with prior use of direct oral anticoagulants have a lower risk of in-hospital mortality than stroke patients with prior use of warfarin.", "UCB T cells reduce TCR diversity after transplantation.", "Patients in stable partnerships have a faster progression from HIV to AIDS.", "Chronic aerobic exercise alters endothelial function, improving vasodilating mechanisms mediated by NO.", "Bone marrow cells contribute to adult macrophage compartments.", "T regulatory cells (tTregs) lacking \u03b1v\u03b28 are more adept at suppressing pathogenic T-cell responses during active inflammation.", "High levels of copeptin decrease risk of diabetes.", "Podocytes are motile and migrate in the presence of injury.", "Febrile seizures increase the threshold for development of epilepsy."], "hard_negatives": ["Breast cancer development is determined exclusively by genetic factors.", "Women with a higher birth weight are more likely to develop breast cancer later in life.", "Birth-weight is positively associated with breast cancer.", "The risk of breast cancer among parous women increases with placental weight of pregnancies, and this association is strongest for premenopausal breast cancer.", "The relationship between a breast cancer patient's capacity to metabolize tamoxifen and treatment outcome is dependent on the patient's genetic make-up.", "Incidence rates of cervical cancer have increased due to nationwide screening programs based primarily on cytology to detect uterine cervical cancer.", "Incidence rates of cervical cancer have decreased.", "Up-regulation of the p53 pathway and related molecular events casues cancer resistance and results in a significantly shortened lifespan marked by senescent cells and accelerated organismal aging.", "Obesity is determined solely by environmental factors.", "ALDH1 expression is associated with better breast cancer outcomes."], "hard_negative": "Breast cancer development is determined exclusively by genetic factors."}
{"query_id": "198", "query_text": "CCL19 is absent within dLNs.", "negative": "Hypothalamic glutamate neurotransmission is crucial to energy balance.", "negatives": ["Hypothalamic glutamate neurotransmission is crucial to energy balance.", "Febrile seizures reduce the threshold for development of epilepsy.", "Integrating classroom-based collaborative learning with Web-based collaborative learning leads to subpar class performance", "Inositol lipid 3-phosphatase PTEN converts Ptdlns(3,4)P 2 into phosphatidylinositol 4-phosphate.", "Febrile seizures increase the threshold for development of epilepsy.", "The combination of H3K4me3 and H3K79me2 is found in quiescent hair follicle stem cells.", "ADAR1 binds to Dicer to cleave pre-miRNA.", "IFIT1 restricts viral replication by sequestrating mis-capped viral RNAs.", "Inositol lipid 3-phosphatase PTEN converts Ptdlns(3,4)P 2 into phosphatidylinositol 4-phosphate.", "Localization of PIN1 in the roots of Arabidopsis does not require VPS9a"], "hard_negatives": ["CCL19 is absent within dLNs.", "The PPR MDA5 has two N-terminal CARD domains.", "Recurrent mutations occur frequently within CTCF anchor sites adjacent to oncogenes.", "Localization of PIN1 in the Arabidopsis embryo does not require VPS9a", "CR is associated with higher methylation age.", "cSMAC formation enhances weak ligand signalling.", "The locus rs647161 is associated with colorectal carcinoma.", "The ureABIEFGH gene cluster encodes urease maturation proteins : UreD/UreH, UreE, UreF, and UreG.", "The PRR MDA5 has a central DExD/H RNA helices domain.", "Peroxynitrite is required for nitration of TCR/CD8."], "hard_negative": "CCL19 is absent within dLNs."}
{"query_id": "208", "query_text": "CHEK2 is not associated with breast cancer.", "negative": "The genomic aberrations found in matasteses are very similar to those found in the primary tumor.", "negatives": ["The genomic aberrations found in matasteses are very similar to those found in the primary tumor.", "Deletion of \u03b1v\u03b28 does not result in a spontaneous inflammatory phenotype.", "Cells lacking clpC have a defect in sporulation efficiency in Bacillus subtilis.", "Glycolysis is one of the primary glycometabolic pathways in cells.", "Ly6C hi monocytes have a lower inflammatory capacity compared to their Ly6C lo counterparts.", "Individuals with low serum vitamin D concentrations have increased risk of multiple sclerosis.", "DMRT1 is a sex-determining gene that is epigenetically regulated by the MHM region.", "Mice that lack Interferon-\u03b3 or its receptor exhibit high resistance to experimental autoimmune myocarditis.", "Macrolides have no protective effect against myocardial infarction.", "Albendazole is used to treat lymphatic filariasis."], "hard_negatives": ["CHEK2 is not associated with breast cancer.", "ALDH1 expression is associated with poorer prognosis in breast cancer.", "ALDH1 expression is associated with better breast cancer outcomes.", "A deficiency of vitamin B12 increases blood levels of homocysteine.", "NR5A2 is important in development of endometrial tissues.", "mTORC2 regulates intracellular cysteine levels through xCT inhibition.", "The risk of breast cancer among parous women increases with placental weight of pregnancies, and this association is strongest for premenopausal breast cancer.", "The extracellular domain of TMEM27 is cleaved in human beta cells.", "Women with a higher birth weight are more likely to develop breast cancer later in life.", "Birth-weight is positively associated with breast cancer."], "hard_negative": "CHEK2 is not associated with breast cancer."}
{"query_id": "212", "query_text": "CR is associated with higher methylation age.", "negative": "Flexible molecules experience greater steric hindrance in the tumor microenviroment than rigid molecules.", "negatives": ["Flexible molecules experience greater steric hindrance in the tumor microenviroment than rigid molecules.", "Replacement of histone H2A with H2A.Z slows gene activation in yeasts by stabilizing +1 nucleosomes.", "AMP-activated protein kinase (AMPK) activation increases inflammation-related fibrosis in the lungs.", "The availability of safe places to study is not effective at decreasing homelessness.", "Mutant mice lacking SVCT2 have greatly increased ascorbic acid levels in both brain and adrenals.", "The DdrB protein from Deinococcus radiodurans is an alternative SSB.", "Lack of clpC does not affect sporulation efficiency in Bacillus subtilis cells.", "NOX2-independent pathways can generate peroxynitrite by reacting with nitrogen intermediates.", "Silencing of Bcl2 is important for the maintenance and progression of tumors.", "The arm density of TatAd complexes is due to structural rearrangements within Class1 TatAd complexes such as the 'charge zipper mechanism'."], "hard_negatives": ["CR is associated with higher methylation age.", "Low nucleosome occupancy correlates with low methylation levels across species.", "ALDH1 expression is associated with poorer prognosis in breast cancer.", "ALDH1 expression is associated with better breast cancer outcomes.", "Ly6C hi monocytes have a lower inflammatory capacity compared to their Ly6C lo counterparts.", "Histone demethylase recruitment and a transient decrease in histone methylation is necessary for ligand-dependent induction of transcription by nuclear receptors.", "A deficiency of vitamin B12 increases blood levels of homocysteine.", "The locus rs647161 is associated with colorectal carcinoma.", "NR5A2 is important in development of endometrial tissues.", "Ly6C hi monocytes have a lower inflammatory capacity than Ly6C lo monocytes."], "hard_negative": "CR is associated with higher methylation age."}
{"query_id": "213", "query_text": "CRP is not predictive of postoperative mortality following Coronary Artery Bypass Graft (CABG) surgery.", "negative": "Incidence rates of cervical cancer have increased due to nationwide screening programs based primarily on cytology to detect uterine cervical cancer.", "negatives": ["Incidence rates of cervical cancer have increased due to nationwide screening programs based primarily on cytology to detect uterine cervical cancer.", "Chronic aerobic exercise alters endothelial function, improving vasodilating mechanisms mediated by NO.", "Insomnia can be effectively treated with cognitive behavioral therapy.", "Obesity decreases life quality.", "cSMAC formation enhances weak ligand signalling.", "N-terminal cleavage reduces success identifying transcription start sites.", "ADAR1 binds to Dicer to cleave pre-miRNA.", "Nanoparticles can be targeted against specific cell types by incorporating aptamers into lipid nanoparticles.", "Hematopoietic Stem Cell purification reaches purity rate of up to 50%.", "Primary cervical cancer screening with HPV detection has higher longitudinal sensitivity than conventional cytology to detect cervical intraepithelial neoplasia grade 2."], "hard_negatives": ["CRP is not predictive of postoperative mortality following Coronary Artery Bypass Graft (CABG) surgery.", "Diabetic patients with acute coronary syndrome experience increased short-term and long-term risk for bleeding events.", "High levels of CRP reduces the risk of exacerbations in chronic obstructive pulmonary disease (COPD).", "Dexamethasone decreases risk of postoperative bleeding.", "The severity of cardiac involvement in amyloidosis can be described by the degree of transmurality of late gadolinium enhancement in MRI.", "LDL cholesterol has no involvement in the development of cardiovascular disease.", "Angiotensin converting enzyme inhibitors are associated with increased risk for functional renal insufficiency.", "GATA-3 is important for hematopoietic stem cell (HSC) function.", "The myocardial lineage develops from cardiac progenitors of mesodermal origin.", "Incidence of heart failure decreased by 10% in women since 1979."], "hard_negative": "CRP is not predictive of postoperative mortality following Coronary Artery Bypass Graft (CABG) surgery."}
{"query_id": "216", "query_text": "CX3CR1 on the Th2 cells impairs T cell survival", "negative": "Ubiquitin ligase UBC13 generates a K63-linked polyubiquitin moiety at PCNA K164.", "negatives": ["Ubiquitin ligase UBC13 generates a K63-linked polyubiquitin moiety at PCNA K164.", "CHEK2 is not associated with breast cancer.", "Headaches are not correlated with cognitive impairment.", "1,000 genomes project enables mapping of genetic sequence variation consisting of rare variants with larger penetrance effects than common variants.", "Albendazole is used to treat lymphatic filariasis.", "Basophils counteract disease development in patients with systemic lupus erythematosus (SLE).", "cSMAC formation enhances weak ligand signalling.", "Ly49Q directs the organization of neutrophil migration to inflammation sites by regulating membrane raft functions.", "Suboptimal nutrition is not predictive of chronic disease", "Synaptic activity enhances local release of brain derived neurotrophic factor from postsynaptic dendrites."], "hard_negatives": ["CX3CR1 on the Th2 cells impairs T cell survival", "CX3CR1 on the Th2 cells promotes T cell survival", "Reduced responsiveness to interleukin-2 in regulatory T cells is associated with greater resistance to autoimmune diseases such as Type 1 Diabetes.", "TCR/CD3 microdomains are a required to induce the immunologic synapse to activate T cells.", "T regulatory cells (tTregs) lacking \u03b1v\u03b28 are more adept at suppressing pathogenic T-cell responses during active inflammation.", "ITAM phosphorylation prevents the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).", "CX3CR1 on the Th2 cells suppresses airway inflammation.", "CX3CR1 on the Th2 cells promotes airway inflammation.", "In adult tissue, most T cells are memory T cells.", "UCB T cells reduce TCR diversity after transplantation."], "hard_negative": "CX3CR1 on the Th2 cells impairs T cell survival"}
{"query_id": "217", "query_text": "CX3CR1 on the Th2 cells promotes T cell survival", "negative": "Peroxynitrite is required for nitration of TCR/CD8.", "negatives": ["Peroxynitrite is required for nitration of TCR/CD8.", "Proteins synthesized at the growth cone are ubiquitinated at a higher rate than proteins from the cell body.", "CX3CR1 on the Th2 cells suppresses airway inflammation.", "Cataract and trachoma are the primary cause of blindness in Southern Sudan.", "Arterioles have a larger lumen diameter than venules.", "Tumor necrosis factor alpha (TNF-\u03b1) and interleukin-1 (IL-1) are pro-inflammatory cytokines that inhibit IL-6 and IL-10.", "APOE4 expression in iPSC-derived neurons increases AlphaBeta production and tau phosphorylation causing GABA neuron degeneration.", "CR is associated with higher methylation age.", "Leuko-increased blood increases infectious complications in red blood cell transfusion.", "Autologous transplantation of mesenchymal stem cells causes fewer opportunistic infections than induction therapy with anti-interleukin-2 receptor antibodies."], "hard_negatives": ["CX3CR1 on the Th2 cells promotes T cell survival", "CX3CR1 on the Th2 cells impairs T cell survival", "Reduced responsiveness to interleukin-2 in regulatory T cells is associated with greater resistance to autoimmune diseases such as Type 1 Diabetes.", "TCR/CD3 microdomains are a required to induce the immunologic synapse to activate T cells.", "T regulatory cells (tTregs) lacking \u03b1v\u03b28 are more adept at suppressing pathogenic T-cell responses during active inflammation.", "ITAM phosphorylation prevents the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).", "CX3CR1 on the Th2 cells suppresses airway inflammation.", "CX3CR1 on the Th2 cells promotes airway inflammation.", "In adult tissue, most T cells are memory T cells.", "UCB T cells maintain high TCR diversity after transplantation."], "hard_negative": "CX3CR1 on the Th2 cells promotes T cell survival"}
{"query_id": "218", "query_text": "CX3CR1 on the Th2 cells promotes airway inflammation.", "negative": "DMRT1 is a sex-determining gene that is epigenetically regulated by the MHM region.", "negatives": ["DMRT1 is a sex-determining gene that is epigenetically regulated by the MHM region.", "Therapeutic use of the drug Dapsone to treat pyoderma gangrenous is based on anecdotal evidence.", "The amount of publicly available DNA data doubles every 10 years.", "Increased vessel density along with a reduction in fibrosis decreases the efficacy of chemotherapy treatments.", "Taking 400mg of \u03b1-tocopheryl acetate helps to prevent prostate cancer.", "UCB T cells maintain high TCR diversity after transplantation.", "Histone demethylase recruitment and a transient decrease in histone methylation is necessary for ligand-dependent induction of transcription by nuclear receptors.", "Taking 400mg of \u03b1-tocopheryl acetate helps to prevent prostate cancer.", "Anthrax spores can be disposed of easily after they are dispersed.", "ALDH1 expression is associated with poorer prognosis in breast cancer."], "hard_negatives": ["CX3CR1 on the Th2 cells promotes airway inflammation.", "CX3CR1 on the Th2 cells suppresses airway inflammation.", "Crosstalk between dendritic cells (DCs) and innate lymphoid cells (ILCs) is important in the regulation of intestinal homeostasis.", "CX3CR1 on the Th2 cells promotes T cell survival", "CX3CR1 on the Th2 cells impairs T cell survival", "Immune responses result in the development of inflammatory Th17 cells and anti-inflammatory iTregs.", "AMP-activated protein kinase (AMPK) activation increases inflammation-related fibrosis in the lungs.", "Blocking the interaction between TDP-43 and respiratory complex I proteins ND3 and ND6 leads to increased TDP-43-induced neuronal loss.", "Ly49Q directs the organization of neutrophil migration to inflammation sites by regulating membrane raft functions.", "Ly6C hi monocytes have a lower inflammatory capacity compared to their Ly6C lo counterparts."], "hard_negative": "CX3CR1 on the Th2 cells promotes airway inflammation."}
{"query_id": "219", "query_text": "CX3CR1 on the Th2 cells suppresses airway inflammation.", "negative": "CX3CR1 on the Th2 cells promotes airway inflammation.", "negatives": ["CX3CR1 on the Th2 cells promotes airway inflammation.", "cSMAC formation enhances weak ligand signalling.", "The amount of publicly available DNA data doubles every 10 years.", "Anthrax spores can be disposed of easily after they are dispersed.", "Obesity decreases life quality.", "All hematopoietic stem cells segregate their chromosomes randomly.", "N-terminal cleavage reduces success identifying transcription start sites.", "Immune responses result in the development of inflammatory Th17 cells and anti-inflammatory iTregs.", "Arginine 90 in p150n is important for interaction with EB1.", "High cardiopulmonary fitness causes increased mortality rate."], "hard_negatives": ["CX3CR1 on the Th2 cells suppresses airway inflammation.", "CX3CR1 on the Th2 cells promotes airway inflammation.", "CX3CR1 on the Th2 cells impairs T cell survival", "CX3CR1 on the Th2 cells promotes T cell survival", "Crosstalk between dendritic cells (DCs) and innate lymphoid cells (ILCs) is important in the regulation of intestinal homeostasis.", "Blocking the interaction between TDP-43 and respiratory complex I proteins ND3 and ND6 leads to increased TDP-43-induced neuronal loss.", "Immune responses result in the development of inflammatory Th17 cells and anti-inflammatory iTregs.", "Ly49Q directs the organization of neutrophil migration to inflammation sites by regulating membrane raft functions.", "AMP-activated protein kinase (AMPK) activation increases inflammation-related fibrosis in the lungs.", "High levels of CRP reduces the risk of exacerbations in chronic obstructive pulmonary disease (COPD)."], "hard_negative": "CX3CR1 on the Th2 cells suppresses airway inflammation."}
{"query_id": "230", "query_text": "Carriers of the alcohol aldehyde dehydrogenase deficiency mutation drink less that non-carries.", "negative": "The ureABIEFGH gene cluster encodes urease maturation proteins : UreD/UreH, UreE, UreF, and UreG.", "negatives": ["The ureABIEFGH gene cluster encodes urease maturation proteins : UreD/UreH, UreE, UreF, and UreG.", "IgA plasma cells that are specific for transglutaminase 2 accumulate in the duodenal mucosa on commencement of a gluten-free diet.", "Downregulation and mislocalization of Scribble prevents cell transformation and mammary tumorigenesis.", "NR5A2 is important in development of endometrial tissues.", "In adult tissue, most T cells are memory T cells.", "Tetraspanin-3 is a causative factor in the development of acute myelogenous leukemia", "Errors in peripheral IV drug administration are most common during bolus administration and multiple-step medicine preparations.", "PDPN promotes efficient motility along stromal surfaces by activating the C-type lectin receptor to rearrange the actin cytoskeleton in dendritic cells.", "Histone demethylase recruitment and a transient decrease in histone methylation is necessary for ligand-dependent induction of transcription by nuclear receptors.", "PD-1 triggering on monocytes reduces IL-10 production by monocytes."], "hard_negatives": ["Carriers of the alcohol aldehyde dehydrogenase deficiency mutation drink less that non-carries.", "HNF4A mutations can cause diabetes in mutant carriers by the age of 14 years", "There is no association between HNF4A mutations and diabetes risks.", "A deficiency of vitamin B12 increases blood levels of homocysteine.", "Taxation of sugar-sweetened beverages had no effect on the incidence rate of type II diabetes in India.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have increased risk for dementia.", "Vitamin D deficiency is unrelated to birth weight.", "Omnivores produce less trimethylamine N-oxide from dietary I-carnitine than vegetarians.", "Ethanol stress decreases the expression of IBP in bacteria.", "High dietary calcium intakes are unnecessary for prevention of secondary hyperparathyroidism in subjects with 25(OH)D levels above 75 nmol/liter."], "hard_negative": "Carriers of the alcohol aldehyde dehydrogenase deficiency mutation drink less that non-carries."}
{"query_id": "232", "query_text": "Cataract and trachoma are the primary cause of blindness in Southern Sudan.", "negative": "ITAM phosphorylation prevents the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).", "negatives": ["ITAM phosphorylation prevents the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).", "Up-regulation of the p53 pathway and related molecular events casues cancer resistance and results in a significantly shortened lifespan marked by senescent cells and accelerated organismal aging.", "NOX2-independent pathways can generate peroxynitrite by reacting with nitrogen intermediates.", "The ureABIEFGH gene cluster encodes urease maturation proteins : UreD/UreH, UreE, UreF, and UreG.", "Smc5/6 engagment drives the activation of SUMO E3 ligase Mms21 by ATP-dependent remolding.", "ITAM phosphorylation prevents the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).", "Deamination of cytidine to uridine on the minus strand of viral DNA results in catastrophic G-to-A mutations in the viral genome.", "The ureABIEFGH gene cluster encodes urease maturation proteins : UreD/UreH, UreE, UreF, and UreG.", "Gene expression does not vary appreciably across genetically identical cells.", "MicroRNA is involved in the regulation of Neural Stem Cell (NSC) differentiation and proliferation dynamic homeostasis"], "hard_negatives": ["Cataract and trachoma are the primary cause of blindness in Southern Sudan.", "Asymptomatic visual impairment screening in elderly populations does not lead to improved vision.", "Infection of human T-cell lymphotropic virus type 1 is most frequent in individuals of African origin.", "A total of 1,000 people in the UK are asymptomatic carriers of vCJD infection.", "Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have a dramatic impact in reducing malaria transmission.", "Headaches are not correlated with cognitive impairment.", "Hypoglycemia increases the risk of dementia.", "Human T-lymphotropic virus type-I-associated myelopathy / tropical spastic paraparesis (HAM/TSP) patients produce Immunoglobulin G (IgG) antibodies which cross-react with an immunodominant epitope in Tax.", "Antiretroviral therapy reduces rates of tuberculosis across a broad range of CD4 strata.", "New drugs for tuberculosis often do not penetrate the necrotic portion of a tuberculosis lesion in high concentrations."], "hard_negative": "Cataract and trachoma are the primary cause of blindness in Southern Sudan."}
{"query_id": "233", "query_text": "Cell autonomous sex determination in somatic cells does not occur in Galliformes.", "negative": "Articles published in open access format are more likely to be cited than traditional journals.", "negatives": ["Articles published in open access format are more likely to be cited than traditional journals.", "Statins increase blood cholesterol.", "There is an inverse relationship between hip fractures and statin use.", "Statins decrease blood cholesterol.", "Exposure to fine particulate air pollution is relate to anxiety prevalence.", "High levels of copeptin decrease risk of diabetes.", "Cytochrome c is released from the mitochondrial intermembrane space to cytosol during apoptosis.", "Proteins synthesized at the growth cone are ubiquitinated at a higher rate than proteins from the cell body.", "Rapid up-regulation and higher basal expression of interferon-induced genes increase survival of granule cell neurons that are infected by West Nile virus.", "Pseudogene PTENP1 regulates the expression of PTEN by functioning as an miRNA decoy."], "hard_negatives": ["Cell autonomous sex determination in somatic cells does not occur in Galliformes.", "Cell autonomous sex determination in somatic cells occurs in Passeriformes.", "Mitochondria are uninvolved in apoptosis.", "In domesticated populations of Saccharomyces cerevisiae, whole chromosome aneuploidy is very uncommon.", "All hematopoietic stem cells segregate their chromosomes randomly.", "Gene expression does not vary appreciably across genetically identical cells.", "Assembly of invadopodia is triggered by focal generation of phosphatidylinositol-3,4-biphosphate and the activation of the nonreceptor tyrosine kinase Src.", "Transplanted human glial cells can differentiate within the host animal.", "Replacement of histone H2A with H2A.Z slows gene activation in yeasts by stabilizing +1 nucleosomes.", "Transplanted human glial progenitor cells are incapable of forming a neural network with host animals' neurons."], "hard_negative": "Cell autonomous sex determination in somatic cells does not occur in Galliformes."}
{"query_id": "236", "query_text": "Cell autonomous sex determination in somatic cells occurs in Passeriformes.", "negative": "Golli-deficient T-cells prefer to differentiate into an anergic phenotype in the adaptive immune response when there are increased levels of Ca2+ in the cytosol.", "negatives": ["Golli-deficient T-cells prefer to differentiate into an anergic phenotype in the adaptive immune response when there are increased levels of Ca2+ in the cytosol.", "Monoclonal antibody targeting of N-cadherin inhibits metastasis.", "High levels of copeptin decrease risk of diabetes.", "Cells undergoing methionine restriction may activate miRNAs.", "Inositol lipid 3-phosphatase PTEN converts Ptdlns(3,4)P 2 into phosphatidylinositol 4-phosphate.", "Tumor necrosis factor alpha (TNF-\u03b1) and interleukin-1 (IL-1) are pro-inflammatory cytokines that inhibit IL-6 and IL-10.", "Activation of PPM1D suppresses p53 function.", "Hypoglycemia increases the risk of dementia.", "The PPR MDA5 has two N-terminal CARD domains.", "Obesity is determined solely by environmental factors."], "hard_negatives": ["Cell autonomous sex determination in somatic cells occurs in Passeriformes.", "Cell autonomous sex determination in somatic cells does not occur in Galliformes.", "All hematopoietic stem cells segregate their chromosomes randomly.", "Mitochondria are uninvolved in apoptosis.", "Gene expression does not vary appreciably across genetically identical cells.", "In domesticated populations of Saccharomyces cerevisiae, whole chromosome aneuploidy is very uncommon.", "Transplanted human glial cells can differentiate within the host animal.", "Transplanted human glial progenitor cells are incapable of forming a neural network with host animals' neurons.", "Assembly of invadopodia is triggered by focal generation of phosphatidylinositol-3,4-biphosphate and the activation of the nonreceptor tyrosine kinase Src.", "The myocardial lineage develops from cardiac progenitors of mesodermal origin."], "hard_negative": "Cell autonomous sex determination in somatic cells occurs in Passeriformes."}
{"query_id": "237", "query_text": "Cells lacking clpC have a defect in sporulation efficiency in Bacillus subtilis.", "negative": "Ly6C hi monocytes have a lower inflammatory capacity than Ly6C lo monocytes.", "negatives": ["Ly6C hi monocytes have a lower inflammatory capacity than Ly6C lo monocytes.", "Autologous transplantation of mesenchymal stem cells causes a higher rate of opportunistic infections than induction therapy with anti-interleukin-2 receptor antibodies.", "The PPR MDA5 has two N-terminal CARD domains.", "There is an inverse relationship between hip fractures and statin use.", "IRG1 has antiviral effects against neurotropic viruses.", "Aspirin inhibits the production of PGE2.", "TCR/CD3 microdomains are a required to induce the immunologic synapse to activate T cells.", "Fz/PCP-dependent Pk localizes to the anterior membrane of neuroectoderm cells during zebrafish neuralation", "Transplanted human glial progenitor cells are incapable of forming a neural network with host animals' neurons.", "IRG1 has antiviral effects against neurotropic viruses."], "hard_negatives": ["Cells lacking clpC have a defect in sporulation efficiency in Bacillus subtilis.", "Lack of clpC does not affect sporulation efficiency in Bacillus subtilis cells.", "Mutant mice lacking SVCT2 have greatly increased ascorbic acid levels in both brain and adrenals.", "Ly6C hi monocytes have a lower inflammatory capacity compared to their Ly6C lo counterparts.", "Proteins synthesized at the growth cone are ubiquitinated at a higher rate than proteins from the cell body.", "Crossover hot spots are not found within gene promoters in Saccharomyces cerevisiae.", "Ly6C hi monocytes have a lower inflammatory capacity than Ly6C lo monocytes.", "Increased vessel density along with a reduction in fibrosis decreases the efficacy of chemotherapy treatments.", "Ethanol stress decreases the expression of IBP in bacteria.", "Upregulation of mosGCTL-1 is induced upon infection with West Nile virus."], "hard_negative": "Cells lacking clpC have a defect in sporulation efficiency in Bacillus subtilis."}
{"query_id": "238", "query_text": "Cells undergoing methionine restriction may activate miRNAs.", "negative": "Women with a higher birth weight are more likely to develop breast cancer later in life.", "negatives": ["Women with a higher birth weight are more likely to develop breast cancer later in life.", "Smc5/6 engagment drives the activation of SUMO E3 ligase Mms21 by ATP-dependent remolding.", "Febrile seizures reduce the threshold for development of epilepsy.", "Deamination of cytidine to uridine on the minus strand of viral DNA results in catastrophic G-to-A mutations in the viral genome.", "Downregulation and mislocalization of Scribble prevents cell transformation and mammary tumorigenesis.", "Low nucleosome occupancy correlates with low methylation levels across species.", "The treatment of cancer patients with co-IR blockade does not cause any adverse autoimmune events.", "The severity of cardiac involvement in amyloidosis can be described by the degree of transmurality of late gadolinium enhancement in MRI.", "The PRR MDA5 has a central DExD/H RNA helices domain.", "High levels of CRP reduces the risk of exacerbations in chronic obstructive pulmonary disease (COPD)."], "hard_negatives": ["Cells undergoing methionine restriction may activate miRNAs.", "Low expression of miR7a does represses target genes and exerts a biological function in ovaries.", "ADAR1 binds to Dicer to cleave pre-miRNA.", "Low expression of miR7a exerts a biological function in testis.", "ITAM phosphorylation prevents the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).", "Pseudogene PTENP1 regulates the expression of PTEN by functioning as an miRNA decoy.", "mTORC2 regulates intracellular cysteine levels through xCT inhibition.", "IFIT1 restricts viral replication by sequestrating mis-capped viral RNAs.", "N348I mutations cause resistance to zidovudine (AZT).", "Mercaptopurine is anabolized into the inactive methylmercaptopurine by thiopurine methyltrasnferase (TPMT)."], "hard_negative": "Cells undergoing methionine restriction may activate miRNAs."}
{"query_id": "239", "query_text": "Cellular aging closely links to an older appearance.", "negative": "Crossover hot spots are not found within gene promoters in Saccharomyces cerevisiae.", "negatives": ["Crossover hot spots are not found within gene promoters in Saccharomyces cerevisiae.", "The locus rs647161 is associated with colorectal carcinoma.", "The repair of Cas9-induced double strand breaks in human DNA is error-prone.", "Alizarin forms hydrogen bonds with residues involved in PGAM1 substrate binding.", "Most termination events in Okazaki fragments are sequence specific.", "NR5A2 is important in development of endometrial tissues.", "Leuko-reduced blood reduces infectious complications in red blood cell transfusion.", "Cold exposure increases BAT recruitment.", "Ultrasound guidance significantly raises the number of traumatic procedures when attempting needle insertion.", "Women with a higher birth weight are more likely to develop breast cancer later in life."], "hard_negatives": ["Cellular aging closely links to an older appearance.", "Modifying the epigenome in the brain affects the normal human aging process by affecting certain genes related to neurogenesis.", "Autophagy declines in aged organisms.", "Obesity is determined solely by environmental factors.", "Up-regulation of the p53 pathway and related molecular events casues cancer resistance and results in a significantly shortened lifespan marked by senescent cells and accelerated organismal aging.", "Gene expression does not vary appreciably across genetically identical cells.", "Obesity decreases life quality.", "Breast cancer development is determined exclusively by genetic factors.", "The myocardial lineage develops from cardiac progenitors of mesodermal origin.", "Macropinocytosis contributes to a cell's supply of amino acids via the intracellular uptake of protein."], "hard_negative": "Cellular aging closely links to an older appearance."}
{"query_id": "248", "query_text": "Chenodeosycholic acid treatment increases whole-body energy expenditure.", "negative": "GATA-3 is important for hematopoietic stem cell (HSC) function.", "negatives": ["GATA-3 is important for hematopoietic stem cell (HSC) function.", "Cytosolic proteins bind to iron-responsive elements on mRNAs coding for DMT1. Cytosolic proteins bind to iron-responsive elements on mRNAs coding for proteins involved in iron uptake.", "IgA plasma cells that are specific for transglutaminase 2 accumulate in the duodenal mucosa on commencement of a gluten-free diet.", "Teaching hospitals do not provide better care than non-teaching hospitals.", "Immune complex triggered cell death leads to extracellular release of neutrophil protein HMGB1.", "Inositol lipid 3-phosphatase PTEN converts Ptdlns(3,4)P 2 into phosphatidylinositol 4-phosphate.", "Most termination events in Okazaki fragments are sequence specific.", "aPKCz causes tumour enhancement by affecting glutamine metabolism.", "Homozygous deletion of murine Sbds gene from osterix-expressing mesenchymal stem and progenitor cells (MPCs) prevents oxidative stress.", "Normal expression of RUNX1 has tumor-promoting effects."], "hard_negatives": ["Chenodeosycholic acid treatment increases whole-body energy expenditure.", "Chenodeosycholic acid treatment reduces whole-body energy expenditure.", "High dietary calcium intakes are unnecessary for prevention of secondary hyperparathyroidism in subjects with 25(OH)D levels above 75 nmol/liter.", "Angiotensin converting enzyme inhibitors are associated with increased risk for functional renal insufficiency.", "Sildenafil improves erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.", "A deficiency of vitamin B12 increases blood levels of homocysteine.", "Statins decrease blood cholesterol.", "Statins increase blood cholesterol.", "Ethanol stress decreases the expression of IBP in bacteria.", "Dexamethasone decreases risk of postoperative bleeding."], "hard_negative": "Chenodeosycholic acid treatment increases whole-body energy expenditure."}
{"query_id": "249", "query_text": "Chenodeosycholic acid treatment reduces whole-body energy expenditure.", "negative": "The genomic aberrations found in matasteses are very similar to those found in the primary tumor.", "negatives": ["The genomic aberrations found in matasteses are very similar to those found in the primary tumor.", "Arginine 90 in p150n is important for interaction with EB1.", "Ribosomopathies have a low degree of cell and tissue specific pathology.", "Errors in peripheral IV drug administration are most common during bolus administration and multiple-step medicine preparations.", "Ivermectin is used to treat lymphatic filariasis.", "Lack of clpC does not affect sporulation efficiency in Bacillus subtilis cells.", "PKG-la plays an essential role in expression of pain hypersensitivity in PGK-la knockout mice.", "Mutant mice lacking SVCT2 have greatly increased ascorbic acid levels in both brain and adrenals.", "High levels of CRP reduces the risk of exacerbations in chronic obstructive pulmonary disease (COPD).", "Hypocretin neurones induce panicprone state in rats."], "hard_negatives": ["Chenodeosycholic acid treatment reduces whole-body energy expenditure.", "Chenodeosycholic acid treatment increases whole-body energy expenditure.", "High dietary calcium intakes are unnecessary for prevention of secondary hyperparathyroidism in subjects with 25(OH)D levels above 75 nmol/liter.", "Angiotensin converting enzyme inhibitors are associated with increased risk for functional renal insufficiency.", "A deficiency of vitamin B12 increases blood levels of homocysteine.", "NOX2-independent pathways can generate peroxynitrite by reacting with nitrogen intermediates.", "Sildenafil improves erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.", "Ethanol stress decreases the expression of IBP in bacteria.", "Dexamethasone decreases risk of postoperative bleeding.", "Statins decrease blood cholesterol."], "hard_negative": "Chenodeosycholic acid treatment reduces whole-body energy expenditure."}
{"query_id": "261", "query_text": "Chronic aerobic exercise alters endothelial function, improving vasodilating mechanisms mediated by NO.", "negative": "Cell autonomous sex determination in somatic cells does not occur in Galliformes.", "negatives": ["Cell autonomous sex determination in somatic cells does not occur in Galliformes.", "Patients in stable partnerships have a faster progression from HIV to AIDS.", "Hypertension is frequently observed in type 1 diabetes patients.", "Ethanol stress decreases the expression of IBP in bacteria.", "Cell autonomous sex determination in somatic cells occurs in Passeriformes.", "FoxO3a activation in neuronal death is mediated by reactive oxygen species (ROS).", "Leuko-reduced blood reduces infectious complications in red blood cell transfusion.", "De novo assembly of sequence data has more specific contigs than unassembled sequence data.", "Cytochrome c is released from the mitochondrial intermembrane space to cytosol during apoptosis.", "Vitamin D deficiency is unrelated to birth weight."], "hard_negatives": ["Chronic aerobic exercise alters endothelial function, improving vasodilating mechanisms mediated by NO.", "AMP-activated protein kinase (AMPK) activation increases inflammation-related fibrosis in the lungs.", "The deregulated and prolonged activation of monocytes has deleterious effects in inflammatory diseases.", "CX3CR1 on the Th2 cells promotes airway inflammation.", "CX3CR1 on the Th2 cells suppresses airway inflammation.", "The severity of cardiac involvement in amyloidosis can be described by the degree of transmurality of late gadolinium enhancement in MRI.", "Angiotensin converting enzyme inhibitors are associated with increased risk for functional renal insufficiency.", "Up-regulation of the p53 pathway and related molecular events casues cancer resistance and results in a significantly shortened lifespan marked by senescent cells and accelerated organismal aging.", "Ly49Q directs the organization of neutrophil migration to inflammation sites by regulating membrane raft functions.", "ALDH1 expression is associated with poorer prognosis in breast cancer."], "hard_negative": "Chronic aerobic exercise alters endothelial function, improving vasodilating mechanisms mediated by NO."}
{"query_id": "268", "query_text": "Cold exposure increases BAT recruitment.", "negative": "Autologous transplantation of mesenchymal stem cells causes a higher rate of opportunistic infections than induction therapy with anti-interleukin-2 receptor antibodies.", "negatives": ["Autologous transplantation of mesenchymal stem cells causes a higher rate of opportunistic infections than induction therapy with anti-interleukin-2 receptor antibodies.", "Ethanol stress decreases the expression of IBP in bacteria.", "Only a minority of cells survive development after differentiation into stress-resistant spores.", "The locus rs647161 is associated with colorectal carcinoma.", "Venules have a thinner or absent smooth layer compared to arterioles.", "Pretreatment with the Arp2/3 inhibitor CK-666 affects lamelliopodia formation.", "ALDH1 expression is associated with better breast cancer outcomes.", "The availability of safe places to study is effective at decreasing homelessness.", "Cells undergoing methionine restriction may activate miRNAs.", "ITAM phosphorylation prevents the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR)."], "hard_negatives": ["Cold exposure increases BAT recruitment.", "Cold exposure reduces BAT recruitment.", "Non-invasive ventilation use should be decreased if there is inadequate response to conventional treatment.", "Exposure to fine particulate air pollution is relate to anxiety prevalence.", "Autophagy declines in aged organisms.", "In mice, P. chabaudi parasites are able to proliferate faster early in infection when inoculated at lower numbers than when inoculated at high numbers.", "Only a minority of cells survive development after differentiation into stress-resistant spores.", "High levels of copeptin decrease risk of diabetes.", "Ethanol stress decreases the expression of IBP in bacteria.", "New drugs for tuberculosis often do not penetrate the necrotic portion of a tuberculosis lesion in high concentrations."], "hard_negative": "Cold exposure increases BAT recruitment."}
{"query_id": "269", "query_text": "Cold exposure reduces BAT recruitment.", "negative": "Microarray results from culture-amplified mixtures of serotypes correlate poorly with microarray results from uncultured mixtures.", "negatives": ["Microarray results from culture-amplified mixtures of serotypes correlate poorly with microarray results from uncultured mixtures.", "Febrile seizures increase the threshold for development of epilepsy.", "The combination of H3K4me3 and H3K79me2 is found in quiescent hair follicle stem cells.", "Headaches are not correlated with cognitive impairment.", "NF2 (Merlin) causes phosphorylation and subsequent cytoplasmic sequestration of YAP in Drosophila by activating LATS1/2 kinases.", "New drugs for tuberculosis often do not penetrate the necrotic portion of a tuberculosis lesion in high concentrations.", "Asymptomatic visual impairment screening in elderly populations does not lead to improved vision.", "Anthrax spores can be disposed of easily after they are dispersed.", "Rapamycin decreases the concentration of triacylglycerols in fruit flies.", "Hematopoietic Stem Cell purification reaches purity rate of up to 50%."], "hard_negatives": ["Cold exposure reduces BAT recruitment.", "Cold exposure increases BAT recruitment.", "Non-invasive ventilation use should be decreased if there is inadequate response to conventional treatment.", "In mice, P. chabaudi parasites are able to proliferate faster early in infection when inoculated at lower numbers than when inoculated at high numbers.", "Autophagy declines in aged organisms.", "New drugs for tuberculosis often do not penetrate the necrotic portion of a tuberculosis lesion in high concentrations.", "Exposure to fine particulate air pollution is relate to anxiety prevalence.", "Only a minority of cells survive development after differentiation into stress-resistant spores.", "Anthrax spores can be disposed of easily after they are dispersed.", "Antiretroviral therapy reduces rates of tuberculosis across a broad range of CD4 strata."], "hard_negative": "Cold exposure reduces BAT recruitment."}
{"query_id": "274", "query_text": "Combination nicotine replacement therapies with varenicline or bupropion lead to significantly higher long-term abstinence rates at 52 weeks than varenicline monotherapy.", "negative": "Dexamethasone decreases risk of postoperative bleeding.", "negatives": ["Dexamethasone decreases risk of postoperative bleeding.", "Integrating classroom-based collaborative learning with Web-based collaborative learning leads to subpar class performance", "Ubiquitin ligase UBC13 generates a K63-linked polyubiquitin moiety at PCNA K164.", "The tip of the inner tube of the toxic type VI secretion system (T6SS) antibacterial effector in Escherichia coli (E. coli) carries toxic effector proteins.", "CCL19 is absent within dLNs.", "PGE 2 promotes intestinal tumor growth by altering the expression of tumor suppressing and DNA repair genes.", "Arginine 90 in p150n is important for interaction with EB1.", "Articles published in open access format are less likely to be cited than traditional journals.", "N-terminal cleavage reduces success identifying transcription start sites.", "Rapid phosphotransfer rates govern fidelity in two component systems"], "hard_negatives": ["Combination nicotine replacement therapies with varenicline or bupropion lead to significantly higher long-term abstinence rates at 52 weeks than varenicline monotherapy.", "Varenicline monotherapy is more effective after 12 weeks of treatment compared to combination nicotine replacement therapies with varenicline or bupropion.", "Sildenafil improves erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.", "Antiretroviral therapy reduces rates of tuberculosis across a broad range of CD4 strata.", "High dietary calcium intakes are unnecessary for prevention of secondary hyperparathyroidism in subjects with 25(OH)D levels above 75 nmol/liter.", "In young and middle-aged adults, current or remote uses of ADHD medications do not increase the risk of serious cardiovascular events.", "Dexamethasone decreases risk of postoperative bleeding.", "The risk of breast cancer among parous women increases with placental weight of pregnancies, and this association is strongest for premenopausal breast cancer.", "Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have a dramatic impact in reducing malaria transmission.", "Taking 400mg of \u03b1-tocopheryl acetate helps to prevent prostate cancer."], "hard_negative": "Combination nicotine replacement therapies with varenicline or bupropion lead to significantly higher long-term abstinence rates at 52 weeks than varenicline monotherapy."}
{"query_id": "275", "query_text": "Combining phosphatidylinositide 3-kinase and MEK 1/2 inhibitors is effective at treating KRAS mutant tumors.", "negative": "The locus rs647161 is associated with colorectal carcinoma.", "negatives": ["The locus rs647161 is associated with colorectal carcinoma.", "CX3CR1 on the Th2 cells suppresses airway inflammation.", "The sliding activity of kinesin-8 protein Kip3 promotes bipolar spindle assembly.", "IRG1 has antiviral effects against neurotropic viruses.", "High dietary calcium intakes are unnecessary for prevention of secondary hyperparathyroidism in subjects with 25(OH)D levels above 75 nmol/liter.", "Articles published in open access format are more likely to be cited than traditional journals.", "A deficiency of vitamin B12 increases blood levels of homocysteine.", "Ly6C hi monocytes have a lower inflammatory capacity compared to their Ly6C lo counterparts.", "0-dimensional biomaterials show inductive properties.", "Healthcare delivery efficiency in crowded delivery centers is impaired by improving structural, logistical, and interpersonal elements."], "hard_negatives": ["Combining phosphatidylinositide 3-kinase and MEK 1/2 inhibitors is effective at treating KRAS mutant tumors.", "CHEK2 is not associated with breast cancer.", "Mercaptopurine is anabolized into the inactive methylmercaptopurine by thiopurine methyltrasnferase (TPMT).", "The genomic aberrations found in matasteses are very similar to those found in the primary tumor.", "aPKCz causes tumour enhancement by affecting glutamine metabolism.", "Angiotensin converting enzyme inhibitors are associated with increased risk for functional renal insufficiency.", "Epigenetic modulating agents (EMAs) modulate antitumor immune response in a cancer model system.", "The treatment of cancer patients with co-IR blockade does not cause any adverse autoimmune events.", "Therapeutic use of the drug Dapsone to treat pyoderma gangrenous is based on anecdotal evidence.", "Metastatic colorectal cancer treated with a single agent fluoropyrimidines resulted in reduced efficacy and lower quality of life when compared with oxaliplatin-based chemotherapy in elderly patients."], "hard_negative": "Combining phosphatidylinositide 3-kinase and MEK 1/2 inhibitors is effective at treating KRAS mutant tumors."}
{"query_id": "279", "query_text": "Commelina yellow mottle virus' (ComYMV) genome consists of 7489 baise pairs.", "negative": "Radioiodine treatment of non-toxic multinodular goitre reduces thyroid volume.", "negatives": ["Radioiodine treatment of non-toxic multinodular goitre reduces thyroid volume.", "MicroRNA is involved in the regulation of Neural Stem Cell (NSC) differentiation and proliferation dynamic homeostasis", "Deamination of cytidine to uridine on the minus strand of viral DNA results in catastrophic G-to-A mutations in the viral genome.", "CX3CR1 on the Th2 cells promotes airway inflammation.", "Less than 10% of the gabonese children with Schimmelpenning-Feuerstein-Mims syndrome (SFM) had a plasma lactate of more than 5mmol/L.", "ITAM phosphorylation prevents the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).", "Anthrax spores can be disposed of easily after they are dispersed.", "Hypoglycemia increases the risk of dementia.", "1/2000 in UK have abnormal PrP positivity.", "The locus rs647161 is associated with colorectal carcinoma."], "hard_negatives": ["Commelina yellow mottle virus' (ComYMV) genome consists of 7489 baise pairs.", "The PPR MDA5 has two N-terminal CARD domains.", "The ureABIEFGH gene cluster encodes urease maturation proteins : UreD/UreH, UreE, UreF, and UreG.", "Human T-lymphotropic virus type-I-associated myelopathy / tropical spastic paraparesis (HAM/TSP) patients produce Immunoglobulin G (IgG) antibodies which cross-react with an immunodominant epitope in Tax.", "The PRR MDA5 has a central DExD/H RNA helices domain.", "The PRR MDA5 is a sensor of RNA virus infection.", "Ubiquitin ligase UBC13 generates a K63-linked polyubiquitin moiety at PCNA K164.", "The ureABIEFGH gene cluster is induced by nickel (II) ion.", "Localization of PIN1 in the roots of Arabidopsis does not require VPS9a", "Active H. pylori urease has a polymeric structure that compromises two subunits, UreA and UreB."], "hard_negative": "Commelina yellow mottle virus' (ComYMV) genome consists of 7489 baise pairs."}
{"query_id": "294", "query_text": "Crossover hot spots are not found within gene promoters in Saccharomyces cerevisiae.", "negative": "Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have a dramatic impact in reducing malaria transmission.", "negatives": ["Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have a dramatic impact in reducing malaria transmission.", "Macropinocytosis contributes to a cell's supply of amino acids via the intracellular uptake of protein.", "Autologous transplantation of mesenchymal stem cells causes fewer opportunistic infections than induction therapy with anti-interleukin-2 receptor antibodies.", "The treatment of cancer patients with co-IR blockade does not cause any adverse autoimmune events.", "5% of perinatal mortality is due to low birth weight.", "Microarray results from culture-amplified mixtures of serotypes correlate poorly with microarray results from uncultured mixtures.", "Tetraspanin-3 is a causative factor in the development of acute myelogenous leukemia", "Errors in peripheral IV drug administration are most common during bolus administration and multiple-step medicine preparations.", "Chenodeosycholic acid treatment increases whole-body energy expenditure.", "The availability of safe places to study is effective at decreasing homelessness."], "hard_negatives": ["Crossover hot spots are not found within gene promoters in Saccharomyces cerevisiae.", "The ureABIEFGH gene cluster encodes urease maturation proteins : UreD/UreH, UreE, UreF, and UreG.", "In domesticated populations of Saccharomyces cerevisiae, whole chromosome aneuploidy is very uncommon.", "Recurrent mutations occur frequently within CTCF anchor sites adjacent to oncogenes.", "Active H. pylori urease has a polymeric structure that compromises two subunits, UreA and UreB.", "Cells lacking clpC have a defect in sporulation efficiency in Bacillus subtilis.", "The ureABIEFGH gene cluster is induced by nickel (II) ion.", "Occupancy of ribosomes by IncRNAs mirror 5 0-UTRs", "Low nucleosome occupancy correlates with low methylation levels across species.", "Lack of clpC does not affect sporulation efficiency in Bacillus subtilis cells."], "hard_negative": "Crossover hot spots are not found within gene promoters in Saccharomyces cerevisiae."}
{"query_id": "295", "query_text": "Crosstalk between dendritic cells (DCs) and innate lymphoid cells (ILCs) is important in the regulation of intestinal homeostasis.", "negative": "Headaches are not correlated with cognitive impairment.", "negatives": ["Headaches are not correlated with cognitive impairment.", "Human T-lymphotropic virus type-I-associated myelopathy / tropical spastic paraparesis (HAM/TSP) patients produce Immunoglobulin G (IgG) antibodies which cross-react with an immunodominant epitope in Tax.", "Rapamycin decreases the concentration of triacylglycerols in fruit flies.", "Cellular aging closely links to an older appearance.", "Obesity is determined solely by environmental factors.", "MicroRNA is involved in the regulation of Neural Stem Cell (NSC) differentiation and proliferation dynamic homeostasis", "Vitamin D deficiency is unrelated to birth weight.", "The PPR MDA5 has two N-terminal CARD domains.", "Deleting Raptor reduces G-CSF levels.", "There is no association between HNF4A mutations and diabetes risks."], "hard_negatives": ["Crosstalk between dendritic cells (DCs) and innate lymphoid cells (ILCs) is important in the regulation of intestinal homeostasis.", "Reduced responsiveness to interleukin-2 in regulatory T cells is associated with greater resistance to autoimmune diseases such as Type 1 Diabetes.", "Tumor necrosis factor alpha (TNF-\u03b1) and interleukin-1 (IL-1) are pro-inflammatory cytokines that inhibit IL-6 and IL-10.", "CX3CR1 on the Th2 cells promotes airway inflammation.", "CX3CR1 on the Th2 cells suppresses airway inflammation.", "AMP-activated protein kinase (AMPK) activation increases inflammation-related fibrosis in the lungs.", "Ly49Q directs the organization of neutrophil migration to inflammation sites by regulating membrane raft functions.", "Mice that lack Interferon-\u03b3 or its receptor exhibit high resistance to experimental autoimmune myocarditis.", "Enhanced early production of inflammatory chemokines improves viral control in the lung.", "PD-1 triggering on monocytes reduces IL-10 production by monocytes."], "hard_negative": "Crosstalk between dendritic cells (DCs) and innate lymphoid cells (ILCs) is important in the regulation of intestinal homeostasis."}
{"query_id": "298", "query_text": "Cytochrome c is released from the mitochondrial intermembrane space to cytosol during apoptosis.", "negative": "Recurrent mutations occur frequently within CTCF anchor sites adjacent to oncogenes.", "negatives": ["Recurrent mutations occur frequently within CTCF anchor sites adjacent to oncogenes.", "IgA plasma cells that are specific for transglutaminase 2 accumulate in the duodenal mucosa on commencement of a gluten-free diet.", "ALDH1 expression is associated with better breast cancer outcomes.", "IRG1 has antiviral effects against neurotropic viruses.", "Autologous transplantation of mesenchymal stem cells causes fewer opportunistic infections than induction therapy with anti-interleukin-2 receptor antibodies.", "Women with a higher birth weight are more likely to develop breast cancer later in life.", "Tirasemtiv has no effect on fast-twitch muscle.", "Functional consequences of genomic alterations due to Myelodysplastic syndrome (MDS) are poorly understood due to the lack of an animal model.", "ITAM phosphorylation prevents the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).", "The availability of safe places to study is effective at decreasing homelessness."], "hard_negatives": ["Cytochrome c is released from the mitochondrial intermembrane space to cytosol during apoptosis.", "Mitochondria are uninvolved in apoptosis.", "NFAT4 activation requires IP3R-mediated Ca2+ mobilization.", "FoxO3a activation in neuronal death is mediated by reactive oxygen species (ROS).", "Deamination of cytidine to uridine on the minus strand of viral DNA results in catastrophic G-to-A mutations in the viral genome.", "A deficiency of vitamin B12 increases blood levels of homocysteine.", "Active H. pylori urease has a polymeric structure that compromises two subunits, UreA and UreB.", "Free histones are degraded by a Rad53-dependent mechanism once DNA has been replicated.", "Replacement of histone H2A with H2A.Z slows gene activation in yeasts by stabilizing +1 nucleosomes.", "mTORC2 regulates intracellular cysteine levels through xCT inhibition."], "hard_negative": "Cytochrome c is released from the mitochondrial intermembrane space to cytosol during apoptosis."}
{"query_id": "300", "query_text": "Cytosolic proteins bind to iron-responsive elements on mRNAs coding for DMT1. Cytosolic proteins bind to iron-responsive elements on mRNAs coding for proteins involved in iron uptake.", "negative": "Mitochondria are uninvolved in apoptosis.", "negatives": ["Mitochondria are uninvolved in apoptosis.", "Cell autonomous sex determination in somatic cells does not occur in Galliformes.", "GATA-3 is important for hematopoietic stem cell (HSC) function.", "CR is associated with higher methylation age.", "In transgenic mice harboring green florescent protein under the control of the Sox2 promoter, less than ten percent of the cells with green florescent colocalize with cell proliferation markers.", "Fz/PCP-dependent Pk localizes to the anterior membrane of notochord cells during zebrafish neuralation.", "New drugs for tuberculosis often do not penetrate the necrotic portion of a tuberculosis lesion in high concentrations.", "Deleting Raptor reduces G-CSF levels.", "Low expression of miR7a does represses target genes and exerts a biological function in ovaries.", "CX3CR1 on the Th2 cells promotes airway inflammation."], "hard_negatives": ["Cytosolic proteins bind to iron-responsive elements on mRNAs coding for DMT1. Cytosolic proteins bind to iron-responsive elements on mRNAs coding for proteins involved in iron uptake.", "Many proteins in human cells can be post-translationally modified at lysine residues via acetylation.", "The arm density of TatAd complexes is due to structural rearrangements within Class1 TatAd complexes such as the 'charge zipper mechanism'.", "mTORC2 regulates intracellular cysteine levels through xCT inhibition.", "The ureABIEFGH gene cluster is induced by nickel (II) ion.", "A deficiency of vitamin B12 increases blood levels of homocysteine.", "Omnivores produce less trimethylamine N-oxide from dietary I-carnitine than vegetarians.", "Mutations in G-Beta protein GNB2 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.", "NF2 (Merlin) causes phosphorylation and subsequent cytoplasmic sequestration of YAP in Drosophila by activating LATS1/2 kinases.", "Arginine 90 in p150n is important for interaction with EB1."], "hard_negative": "Cytosolic proteins bind to iron-responsive elements on mRNAs coding for DMT1. Cytosolic proteins bind to iron-responsive elements on mRNAs coding for proteins involved in iron uptake."}
{"query_id": "303", "query_text": "DMRT1 is a sex-determining gene that is epigenetically regulated by the MHM region.", "negative": "TNFAIP3 is a tumor suppressor in glioblastoma.", "negatives": ["TNFAIP3 is a tumor suppressor in glioblastoma.", "Primary cervical cancer screening with HPV detection has higher longitudinal sensitivity than conventional cytology to detect cervical intraepithelial neoplasia grade 2.", "Vitamin D deficiency effects the term of delivery.", "APOE4 expression in iPSC-derived neurons increases AlphaBeta production and tau phosphorylation causing GABA neuron degeneration.", "Articles published in open access format are more likely to be cited than traditional journals.", "The loss of the TET protein functions may have dire biological consequences, such as myeloid cancers.", "Hypothalamic glutamate neurotransmission is crucial to energy balance.", "Recurrent mutations occur frequently within CTCF anchor sites adjacent to oncogenes.", "APOE4 expression in iPSC-derived neurons increases AlphaBeta production and tau phosphorylation causing GABA neuron degeneration.", "In mouse models, the loss of CSF1R facilitates MOZ-TIF2-induced leuekmogenesis."], "hard_negatives": ["DMRT1 is a sex-determining gene that is epigenetically regulated by the MHM region.", "The ureABIEFGH gene cluster encodes urease maturation proteins : UreD/UreH, UreE, UreF, and UreG.", "PDPN promotes efficient motility along stromal surfaces by activating the C-type lectin receptor to rearrange the actin cytoskeleton in dendritic cells.", "The PPR MDA5 has two N-terminal CARD domains.", "Activation of PPM1D suppresses p53 function.", "Low expression of miR7a does represses target genes and exerts a biological function in ovaries.", "The locus rs647161 is associated with colorectal carcinoma.", "Low expression of miR7a exerts a biological function in testis.", "The risk of breast cancer among parous women increases with placental weight of pregnancies, and this association is strongest for premenopausal breast cancer.", "aPKCz causes tumour enhancement by affecting glutamine metabolism."], "hard_negative": "DMRT1 is a sex-determining gene that is epigenetically regulated by the MHM region."}
{"query_id": "312", "query_text": "De novo assembly of sequence data has more specific contigs than unassembled sequence data.", "negative": "The treatment of cancer patients with co-IR blockade does not cause any adverse autoimmune events.", "negatives": ["The treatment of cancer patients with co-IR blockade does not cause any adverse autoimmune events.", "Subcutaneous fat depots undergo extensive browning processes after cold exposure.", "Increased vessel density along with a reduction in fibrosis decreases the efficacy of chemotherapy treatments.", "NR5A2 is important in development of endometrial tissues.", "N348I mutations cause resistance to zidovudine (AZT).", "1/2000 in UK have abnormal PrP positivity.", "Lupus-prone mice infected with curliproducing bacteria have higher autoantibody titers compared to controls.", "The severity of cardiac involvement in amyloidosis can be described by the degree of transmurality of late gadolinium enhancement in MRI.", "The risk of male prisoners harming themselves is ten times that of female prisoners.", "Radioiodine treatment of non-toxic multinodular goitre reduces thyroid volume."], "hard_negatives": ["De novo assembly of sequence data has more specific contigs than unassembled sequence data.", "Microarray results from culture-amplified mixtures of serotypes correlate poorly with microarray results from uncultured mixtures.", "Most termination events in Okazaki fragments are sequence specific.", "Flexible molecules experience greater steric hindrance in the tumor microenviroment than rigid molecules.", "0-dimensional biomaterials show inductive properties.", "Functional consequences of genomic alterations due to Myelodysplastic syndrome (MDS) are poorly understood due to the lack of an animal model.", "Nanoparticles can be targeted against specific cell types by incorporating aptamers into lipid nanoparticles.", "The amount of publicly available DNA data doubles every 10 years.", "1,000 genomes project enables mapping of genetic sequence variation consisting of rare variants with larger penetrance effects than common variants.", "Occupancy of ribosomes by IncRNAs do not make functional peptides."], "hard_negative": "De novo assembly of sequence data has more specific contigs than unassembled sequence data."}
{"query_id": "314", "query_text": "Deamination of cytidine to uridine on the minus strand of viral DNA results in catastrophic G-to-A mutations in the viral genome.", "negative": "Combination nicotine replacement therapies with varenicline or bupropion lead to significantly higher long-term abstinence rates at 52 weeks than varenicline monotherapy.", "negatives": ["Combination nicotine replacement therapies with varenicline or bupropion lead to significantly higher long-term abstinence rates at 52 weeks than varenicline monotherapy.", "Ethanol stress decreases the expression of IBP in bacteria.", "Immune responses result in the development of inflammatory Th17 cells and anti-inflammatory iTregs.", "The myocardial lineage develops from cardiac progenitors of mesodermal origin.", "The PRR MDA5 has a central DExD/H RNA helices domain.", "CX3CR1 on the Th2 cells promotes T cell survival", "A high microerythrocyte count raises vulnerability to severe anemia in homozygous alpha (+)- thalassemia trait subjects.", "APOE4 expression in iPSC-derived neurons increases AlphaBeta production and tau phosphorylation, delaying GABA neuron degeneration.", "Aspirin inhibits the production of PGE2.", "Taking 400mg of \u03b1-tocopheryl acetate helps to prevent prostate cancer."], "hard_negatives": ["Deamination of cytidine to uridine on the minus strand of viral DNA results in catastrophic G-to-A mutations in the viral genome.", "N348I mutations cause resistance to zidovudine (AZT).", "Active H. pylori urease has a polymeric structure that compromises two subunits, UreA and UreB.", "Helminths interfere with immune system control of macrophages activated by IL-4 favor Mycobacterium tuberculosis replication.", "Mutations in G-Beta protein GNB2 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.", "Cytochrome c is released from the mitochondrial intermembrane space to cytosol during apoptosis.", "Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have a dramatic impact in reducing malaria transmission.", "HNF4A mutations can cause diabetes in mutant carriers by the age of 14 years", "Deletion of \u03b1v\u03b28 does not result in a spontaneous inflammatory phenotype.", "Antibiotic induced alterations in the gut microbiome reduce resistance against Clostridium difficile"], "hard_negative": "Deamination of cytidine to uridine on the minus strand of viral DNA results in catastrophic G-to-A mutations in the viral genome."}
{"query_id": "324", "query_text": "Deleting Raptor reduces G-CSF levels.", "negative": "Rapamycin decreases the concentration of triacylglycerols in fruit flies.", "negatives": ["Rapamycin decreases the concentration of triacylglycerols in fruit flies.", "Ly49Q directs the organization of neutrophil migration to inflammation sites by regulating membrane raft functions.", "Ly6C hi monocytes have a lower inflammatory capacity compared to their Ly6C lo counterparts.", "Ivermectin is used to treat onchocerciasis.", "The center of the granuloma in an immune cell induces a pro-inflammatory immune response.", "Human T-lymphotropic virus type-I-associated myelopathy / tropical spastic paraparesis (HAM/TSP) patients produce Immunoglobulin G (IgG) antibodies which cross-react with an immunodominant epitope in Tax.", "N348I mutations cause resistance to zidovudine (AZT).", "Mitochondria are uninvolved in apoptosis.", "Pretreatment with the Arp2/3 inhibitor CK-666 affects lamelliopodia formation.", "APOE4 expression in iPSC-derived neurons increases AlphaBeta production and tau phosphorylation, delaying GABA neuron degeneration."], "hard_negatives": ["Deleting Raptor reduces G-CSF levels.", "In mouse models, the loss of CSF1R facilitates MOZ-TIF2-induced leuekmogenesis.", "cSMAC formation enhances weak ligand signalling.", "Mutations in G-Beta protein GNB2 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.", "Pyridostatin destabilizes the G - quadruplex in the telomeric region.", "Glycolysis is one of the primary glycometabolic pathways in cells.", "Leukemia associated Rho guanine nucleotide-exchange factor represses RhoA in response to SRC activation.", "Deletion of \u03b1v\u03b28 does not result in a spontaneous inflammatory phenotype.", "Mice that lack Interferon-\u03b3 or its receptor exhibit high resistance to experimental autoimmune myocarditis.", "Antiretroviral therapy reduces rates of tuberculosis across a broad range of CD4 strata."], "hard_negative": "Deleting Raptor reduces G-CSF levels."}
{"query_id": "327", "query_text": "Deletion of \u03b1v\u03b28 does not result in a spontaneous inflammatory phenotype.", "negative": "PGE 2 promotes intestinal tumor growth by altering the expression of tumor suppressing and DNA repair genes.", "negatives": ["PGE 2 promotes intestinal tumor growth by altering the expression of tumor suppressing and DNA repair genes.", "The treatment of cancer patients with co-IR blockade does not cause any adverse autoimmune events.", "Bone marrow cells contribute to adult macrophage compartments.", "Arterioles have a larger lumen diameter than venules.", "Modifying the epigenome in the brain affects the normal human aging process by affecting certain genes related to neurogenesis.", "Mice defective for deoxyribonucleic acid (DNA) polymerase I (polI) reveal increased sensitivity to ionizing radiation (IR).", "Therapeutic use of the drug Dapsone to treat pyoderma gangrenous is based on anecdotal evidence.", "The extracellular domain of TMEM27 is cleaved in human beta cells.", "There is an inverse relationship between hip fractures and statin use.", "The myocardial lineage develops from cardiac progenitors of mesodermal origin."], "hard_negatives": ["Deletion of \u03b1v\u03b28 does not result in a spontaneous inflammatory phenotype.", "T regulatory cells (tTregs) lacking \u03b1v\u03b28 are more adept at suppressing pathogenic T-cell responses during active inflammation.", "N348I mutations cause resistance to zidovudine (AZT).", "Mice that lack Interferon-\u03b3 or its receptor exhibit high resistance to experimental autoimmune myocarditis.", "Antiretroviral therapy reduces rates of tuberculosis across a broad range of CD4 strata.", "Enhanced early production of inflammatory chemokines improves viral control in the lung.", "TNFAIP3 is a tumor suppressor in glioblastoma.", "p16INK4A accumulation is  linked to an abnormal wound response caused by the microinvasive step of advanced Oral Potentially Malignant Lesions (OPMLs).", "New drugs for tuberculosis often do not penetrate the necrotic portion of a tuberculosis lesion in high concentrations.", "PD-1 triggering on monocytes reduces IL-10 production by monocytes."], "hard_negative": "Deletion of \u03b1v\u03b28 does not result in a spontaneous inflammatory phenotype."}
{"query_id": "338", "query_text": "Dexamethasone decreases risk of postoperative bleeding.", "negative": "0-dimensional biomaterials show inductive properties.", "negatives": ["0-dimensional biomaterials show inductive properties.", "Rapamycin decreases the concentration of triacylglycerols in fruit flies.", "Subcutaneous fat depots undergo extensive browning processes after cold exposure.", "Immune complex triggered cell death leads to extracellular release of neutrophil protein HMGB1.", "NF2 (Merlin) prevents phosphorylation and subsequent cytoplasmic sequestration of YAP in Drosophila.", "Pretreatment with the Arp2/3 inhibitor CK-666 affects lamelliopodia formation.", "Homozygous deletion of murine Sbds gene from osterix-expressing mesenchymal stem and progenitor cells (MPCs) prevents oxidative stress.", "NOX2-independent pathways can generate peroxynitrite by reacting with nitrogen intermediates.", "Incidence rates of cervical cancer have decreased.", "Bariatric surgery has a positive impact on mental health."], "hard_negatives": ["Dexamethasone decreases risk of postoperative bleeding.", "Sildenafil improves erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.", "Stroke patients with prior use of direct oral anticoagulants have a lower risk of in-hospital mortality than stroke patients with prior use of warfarin.", "Diabetic patients with acute coronary syndrome experience increased short-term and long-term risk for bleeding events.", "Varenicline monotherapy is more effective after 12 weeks of treatment compared to combination nicotine replacement therapies with varenicline or bupropion.", "In young and middle-aged adults, current or remote uses of ADHD medications do not increase the risk of serious cardiovascular events.", "CRP is not predictive of postoperative mortality following Coronary Artery Bypass Graft (CABG) surgery.", "LDL cholesterol has no involvement in the development of cardiovascular disease.", "High levels of CRP reduces the risk of exacerbations in chronic obstructive pulmonary disease (COPD).", "Metastatic colorectal cancer treated with a single agent fluoropyrimidines resulted in reduced efficacy and lower quality of life when compared with oxaliplatin-based chemotherapy in elderly patients."], "hard_negative": "Dexamethasone decreases risk of postoperative bleeding."}
{"query_id": "343", "query_text": "Diabetic patients with acute coronary syndrome experience increased short-term and long-term risk for bleeding events.", "negative": "Flexible molecules experience greater steric hindrance in the tumor microenviroment than rigid molecules.", "negatives": ["Flexible molecules experience greater steric hindrance in the tumor microenviroment than rigid molecules.", "Bariatric surgery has a positive impact on mental health.", "Free histones are degraded by a Rad53-dependent mechanism once DNA has been replicated.", "Discrimination between the initiator and elongation tRNAs depends on the translation initiation factor IF3.", "There is an inverse relationship between hip fractures and statin use.", "Albendazole is used to treat lymphatic filariasis.", "Sildenafil improves erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.", "Women with a higher birth weight are more likely to develop breast cancer later in life.", "High cardiopulmonary fitness causes increased mortality rate.", "Histone demethylase recruitment and a transient decrease in histone methylation is necessary for ligand-dependent induction of transcription by nuclear receptors."], "hard_negatives": ["Diabetic patients with acute coronary syndrome experience increased short-term and long-term risk for bleeding events.", "CRP is not predictive of postoperative mortality following Coronary Artery Bypass Graft (CABG) surgery.", "In young and middle-aged adults, current or remote uses of ADHD medications do not increase the risk of serious cardiovascular events.", "Mice that lack Interferon-\u03b3 or its receptor exhibit high resistance to experimental autoimmune myocarditis.", "High levels of CRP reduces the risk of exacerbations in chronic obstructive pulmonary disease (COPD).", "Dexamethasone decreases risk of postoperative bleeding.", "Hypertension is frequently observed in type 1 diabetes patients.", "Errors in peripheral IV drug administration are most common during bolus administration and multiple-step medicine preparations.", "Stroke patients with prior use of direct oral anticoagulants have a lower risk of in-hospital mortality than stroke patients with prior use of warfarin.", "Functional consequences of genomic alterations due to Myelodysplastic syndrome (MDS) are poorly understood due to the lack of an animal model."], "hard_negative": "Diabetic patients with acute coronary syndrome experience increased short-term and long-term risk for bleeding events."}
{"query_id": "350", "query_text": "Discrimination between the initiator and elongation tRNAs depends on the translation initiation factor IF3.", "negative": "Hypocretin neurones induce panicprone state in rats.", "negatives": ["Hypocretin neurones induce panicprone state in rats.", "The extracellular domain of TMEM27 is cleaved in human beta cells.", "The tip of the inner tube of the toxic type VI secretion system (T6SS) antibacterial effector in Escherichia coli (E. coli) carries toxic effector proteins.", "Glycolysis is one of the primary glycometabolic pathways in cells.", "Alizarin forms hydrogen bonds with residues involved in PGAM1 substrate binding.", "Combination nicotine replacement therapies with varenicline or bupropion lead to significantly higher long-term abstinence rates at 52 weeks than varenicline monotherapy.", "Less than 10% of the gabonese children with Schimmelpenning-Feuerstein-Mims syndrome (SFM) had a plasma lactate of more than 5mmol/L.", "During the primary early antibody response activated B cells migrate toward the inner-and outer paracortical areas where oxysterol accumulation is generated by stromal cells.", "IRG1 has antiviral effects against neurotropic viruses.", "During the primary early antibody response activated B cells migrate toward the inner-and outer paracortical areas where oxysterol accumulation is generated by stromal cells."], "hard_negatives": ["Discrimination between the initiator and elongation tRNAs depends on the translation initiation factor IF3.", "N-terminal cleavage increases success identifying transcription start sites.", "N-terminal cleavage reduces success identifying transcription start sites.", "Histone demethylase recruitment and a transient decrease in histone methylation is necessary for ligand-dependent induction of transcription by nuclear receptors.", "Occupancy of ribosomes by IncRNAs mirror 5 0-UTRs", "The arm density of TatAd complexes is due to structural rearrangements within Class1 TatAd complexes such as the 'charge zipper mechanism'.", "Occupancy of ribosomes by IncRNAs do not make functional peptides.", "Most termination events in Okazaki fragments are sequence specific.", "PDPN promotes efficient motility along stromal surfaces by activating the C-type lectin receptor to rearrange the actin cytoskeleton in dendritic cells.", "Ly49Q directs the organization of neutrophil migration to inflammation sites by regulating membrane raft functions."], "hard_negative": "Discrimination between the initiator and elongation tRNAs depends on the translation initiation factor IF3."}
{"query_id": "354", "query_text": "Downregulation and mislocalization of Scribble prevents cell transformation and mammary tumorigenesis.", "negative": "High levels of CRP reduces the risk of exacerbations in chronic obstructive pulmonary disease (COPD).", "negatives": ["High levels of CRP reduces the risk of exacerbations in chronic obstructive pulmonary disease (COPD).", "New drugs for tuberculosis often do not penetrate the necrotic portion of a tuberculosis lesion in high concentrations.", "CCL19 is absent within dLNs.", "Mutations in G-Beta protein GNB2 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.", "Many proteins in human cells can be post-translationally modified at lysine residues via acetylation.", "Autologous transplantation of mesenchymal stem cells has lower rates of rejection than induction therapy with anti-interleukin-2 receptor antibodies.", "Venules have a larger lumen diameter than arterioles.", "Arterioles have a larger lumen diameter than venules.", "Only a minority of cells survive development after differentiation into stress-resistant spores.", "N348I mutations cause resistance to zidovudine (AZT)."], "hard_negatives": ["Downregulation and mislocalization of Scribble prevents cell transformation and mammary tumorigenesis.", "Silencing of Bcl2 is important for the maintenance and progression of tumors.", "The genomic aberrations found in matasteses are very similar to those found in the primary tumor.", "The severity of cardiac involvement in amyloidosis can be described by the degree of transmurality of late gadolinium enhancement in MRI.", "Normal expression of RUNX1 has tumor-promoting effects.", "Homozygous deletion of murine Sbds gene from osterix-expressing mesenchymal stem and progenitor cells (MPCs) prevents oxidative stress.", "Functional consequences of genomic alterations due to Myelodysplastic syndrome (MDS) are poorly understood due to the lack of an animal model.", "Breast cancer development is determined exclusively by genetic factors.", "Up-regulation of the p53 pathway and related molecular events casues cancer resistance and results in a significantly shortened lifespan marked by senescent cells and accelerated organismal aging.", "PGE 2 promotes intestinal tumor growth by altering the expression of tumor suppressing and DNA repair genes."], "hard_negative": "Downregulation and mislocalization of Scribble prevents cell transformation and mammary tumorigenesis."}
{"query_id": "362", "query_text": "During the primary early antibody response activated B cells migrate toward the inner-and outer paracortical areas where oxysterol accumulation is generated by stromal cells.", "negative": "Vitamin D deficiency effects the term of delivery.", "negatives": ["Vitamin D deficiency effects the term of delivery.", "The US health care system can save up to $750 million if 7% of patients waiting for kidney transplants participate in the optimized national kidney paired donation program.", "PKG-la plays an essential role in expression of pain hypersensitivity in PGK-la knockout mice.", "Reduced responsiveness to interleukin-2 in regulatory T cells is associated with greater resistance to autoimmune diseases such as Type 1 Diabetes.", "Primary pro-inflammatory cytokines induce secondary pro- and anti-inflammatory mediators.", "Recurrent mutations occur frequently within CTCF anchor sites adjacent to oncogenes.", "Diabetic patients with acute coronary syndrome experience increased short-term and long-term risk for bleeding events.", "Low nucleosome occupancy correlates with low methylation levels across species.", "APOE4 expression in iPSC-derived neurons increases AlphaBeta production and tau phosphorylation causing GABA neuron degeneration.", "Neutrophil extracellular traps (NETs) are released by ANCA-stimulated neutrophils."], "hard_negatives": ["During the primary early antibody response activated B cells migrate toward the inner-and outer paracortical areas where oxysterol accumulation is generated by stromal cells.", "The composition of myosin-II isoform switches from the polarizable B isoform to the more homogenous A isoform during hematopoietic differentiation.", "The single flash-evoked ERG b-wave is generated by activity of ON-bipolar cells.", "PDPN promotes efficient motility along stromal surfaces by activating the C-type lectin receptor to rearrange the actin cytoskeleton in dendritic cells.", "Golli-deficient T-cells prefer to differentiate into an anergic phenotype in the adaptive immune response when there are increased levels of Ca2+ in the cytosol.", "Activator-inhibitor pairs are provided dorsally by Admpchordin.", "Immune responses result in the development of inflammatory Th17 cells and anti-inflammatory iTregs.", "The tip of the inner tube of the toxic type VI secretion system (T6SS) antibacterial effector in Escherichia coli (E. coli) carries toxic effector proteins.", "Primary pro-inflammatory cytokines induce secondary pro- and anti-inflammatory mediators.", "Crosstalk between dendritic cells (DCs) and innate lymphoid cells (ILCs) is important in the regulation of intestinal homeostasis."], "hard_negative": "During the primary early antibody response activated B cells migrate toward the inner-and outer paracortical areas where oxysterol accumulation is generated by stromal cells."}
{"query_id": "380", "query_text": "Enhanced early production of inflammatory chemokines improves viral control in the lung.", "negative": "Flexible molecules experience greater steric hindrance in the tumor microenviroment than rigid molecules.", "negatives": ["Flexible molecules experience greater steric hindrance in the tumor microenviroment than rigid molecules.", "T regulatory cells (tTregs) lacking \u03b1v\u03b28 are more adept at suppressing pathogenic T-cell responses during active inflammation.", "Most termination events in Okazaki fragments are sequence specific.", "Mutations in G-Beta protein GNB2 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.", "Bone marrow cells contribute to adult macrophage compartments.", "Healthcare delivery efficiency in crowded delivery centers is impaired by improving structural, logistical, and interpersonal elements.", "Histone demethylase recruitment and a transient decrease in histone methylation is necessary for ligand-dependent induction of transcription by nuclear receptors.", "FoxO3a activation in neuronal death is mediated by reactive oxygen species (ROS).", "The amount of publicly available DNA data doubles every 10 years.", "A high microerythrocyte count raises vulnerability to severe anemia in homozygous alpha (+)- thalassemia trait subjects."], "hard_negatives": ["Enhanced early production of inflammatory chemokines improves viral control in the lung.", "AMP-activated protein kinase (AMPK) activation increases inflammation-related fibrosis in the lungs.", "Deletion of \u03b1v\u03b28 does not result in a spontaneous inflammatory phenotype.", "Crosstalk between dendritic cells (DCs) and innate lymphoid cells (ILCs) is important in the regulation of intestinal homeostasis.", "Immune responses result in the development of inflammatory Th17 cells and anti-inflammatory iTregs.", "High levels of CRP reduces the risk of exacerbations in chronic obstructive pulmonary disease (COPD).", "Primary pro-inflammatory cytokines induce secondary pro- and anti-inflammatory mediators.", "Mice that lack Interferon-\u03b3 or its receptor exhibit high resistance to experimental autoimmune myocarditis.", "Non-invasive ventilation use should be decreased if there is inadequate response to conventional treatment.", "Increased vessel density along with a reduction in fibrosis decreases the efficacy of chemotherapy treatments."], "hard_negative": "Enhanced early production of inflammatory chemokines improves viral control in the lung."}
{"query_id": "384", "query_text": "Epidemiological disease burden from noncommunicable diseases is more prevalent in low economic settings.", "negative": "The single flash-evoked ERG b-wave is generated by activity of ON-bipolar cells.", "negatives": ["The single flash-evoked ERG b-wave is generated by activity of ON-bipolar cells.", "Taking 400mg of \u03b1-tocopheryl acetate helps to prevent prostate cancer.", "IgA plasma cells that are specific for transglutaminase 2 accumulate in the duodenal mucosa on commencement of a gluten-free diet.", "Commelina yellow mottle virus' (ComYMV) genome consists of 7489 baise pairs.", "Cell autonomous sex determination in somatic cells occurs in Passeriformes.", "Individuals with low serum vitamin D concentrations have increased risk of multiple sclerosis.", "The myocardial lineage develops from cardiac progenitors of mesodermal origin.", "Flexible molecules experience greater steric hindrance in the tumor microenviroment than rigid molecules.", "Fz/PCP-dependent Pk localizes to the anterior membrane of neuroectoderm cells during zebrafish neuralation", "Errors in peripheral IV drug administration are most common during bolus administration and multiple-step medicine preparations."], "hard_negatives": ["Epidemiological disease burden from noncommunicable diseases is more prevalent in low economic settings.", "Suboptimal nutrition is not predictive of chronic disease", "Obesity is determined solely by environmental factors.", "Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have a dramatic impact in reducing malaria transmission.", "5% of perinatal mortality is due to low birth weight.", "High cardiopulmonary fitness causes increased mortality rate.", "Exposure to fine particulate air pollution is relate to anxiety prevalence.", "Infection of human T-cell lymphotropic virus type 1 is most frequent in individuals of African origin.", "Antiretroviral therapy reduces rates of tuberculosis across a broad range of CD4 strata.", "Obesity decreases life quality."], "hard_negative": "Epidemiological disease burden from noncommunicable diseases is more prevalent in low economic settings."}
{"query_id": "385", "query_text": "Epigenetic modulating agents (EMAs) modulate antitumor immune response in a cancer model system.", "negative": "Obesity decreases life quality.", "negatives": ["Obesity decreases life quality.", "Fz/PCP-dependent Pk localizes to the anterior membrane of neuroectoderm cells during zebrafish neuralation", "Tetraspanin-3 is a causative factor in the development of acute myelogenous leukemia", "Asymptomatic visual impairment screening in elderly populations does not lead to improved vision.", "Epidemiological disease burden from noncommunicable diseases is more prevalent in low economic settings.", "Low expression of miR7a exerts a biological function in testis.", "Headaches are not correlated with cognitive impairment.", "PDPN promotes efficient motility along stromal surfaces by activating the C-type lectin receptor to rearrange the actin cytoskeleton in dendritic cells.", "GATA-3 is important for hematopoietic stem cell (HSC) function.", "Cataract and trachoma are the primary cause of blindness in Southern Sudan."], "hard_negatives": ["Epigenetic modulating agents (EMAs) modulate antitumor immune response in a cancer model system.", "Tumor necrosis factor alpha (TNF-\u03b1) and interleukin-1 (IL-1) are pro-inflammatory cytokines that inhibit IL-6 and IL-10.", "Primary pro-inflammatory cytokines induce secondary pro- and anti-inflammatory mediators.", "The treatment of cancer patients with co-IR blockade precipitates adverse autoimmune events.", "Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have a dramatic impact in reducing malaria transmission.", "Nanoparticles can be targeted against specific cell types by incorporating aptamers into lipid nanoparticles.", "The relationship between a breast cancer patient's capacity to metabolize tamoxifen and treatment outcome is dependent on the patient's genetic make-up.", "The treatment of cancer patients with co-IR blockade does not cause any adverse autoimmune events.", "Up-regulation of the p53 pathway and related molecular events casues cancer resistance and results in a significantly shortened lifespan marked by senescent cells and accelerated organismal aging.", "Stroke patients with prior use of direct oral anticoagulants have a lower risk of in-hospital mortality than stroke patients with prior use of warfarin."], "hard_negative": "Epigenetic modulating agents (EMAs) modulate antitumor immune response in a cancer model system."}
{"query_id": "386", "query_text": "Errors in peripheral IV drug administration are most common during bolus administration and multiple-step medicine preparations.", "negative": "Hyperfibrinogenemia increases rates of femoropopliteal bypass thrombosis.", "negatives": ["Hyperfibrinogenemia increases rates of femoropopliteal bypass thrombosis.", "Basophils counteract disease development in patients with systemic lupus erythematosus (SLE).", "Pleiotropic coupling of GLP-1R to intracellular effectors promotes distinct profiles of cellular signaling.", "Helminths interfere with immune system control of macrophages activated by IL-4 favor Mycobacterium tuberculosis replication.", "Increased vessel density along with a reduction in fibrosis decreases the efficacy of chemotherapy treatments.", "PDPN promotes efficient motility along stromal surfaces by activating the C-type lectin receptor to rearrange the actin cytoskeleton in dendritic cells.", "TCR/CD3 microdomains are a required to induce the immunologic synapse to activate T cells.", "Hypertension is frequently observed in type 1 diabetes patients.", "Commelina yellow mottle virus' (ComYMV) genome consists of 7489 baise pairs.", "FoxO3a activation in neuronal death is mediated by reactive oxygen species (ROS)."], "hard_negatives": ["Errors in peripheral IV drug administration are most common during bolus administration and multiple-step medicine preparations.", "Diabetic patients with acute coronary syndrome experience increased short-term and long-term risk for bleeding events.", "Ultrasound guidance significantly raises the number of traumatic procedures when attempting needle insertion.", "Stroke patients with prior use of direct oral anticoagulants have a lower risk of in-hospital mortality than stroke patients with prior use of warfarin.", "CRP is not predictive of postoperative mortality following Coronary Artery Bypass Graft (CABG) surgery.", "Dexamethasone decreases risk of postoperative bleeding.", "The treatment of cancer patients with co-IR blockade precipitates adverse autoimmune events.", "Mice that lack Interferon-\u03b3 or its receptor exhibit high resistance to experimental autoimmune myocarditis.", "The treatment of cancer patients with co-IR blockade does not cause any adverse autoimmune events.", "Functional consequences of genomic alterations due to Myelodysplastic syndrome (MDS) are poorly understood due to the lack of an animal model."], "hard_negative": "Errors in peripheral IV drug administration are most common during bolus administration and multiple-step medicine preparations."}
{"query_id": "388", "query_text": "Ethanol stress decreases the expression of IBP in bacteria.", "negative": "Smc5/6 engagment drives the activation of SUMO E3 ligase Mms21 by ATP-dependent remolding.", "negatives": ["Smc5/6 engagment drives the activation of SUMO E3 ligase Mms21 by ATP-dependent remolding.", "The myocardial lineage develops from cardiac progenitors of mesodermal origin.", "Autologous transplantation of mesenchymal stem cells causes fewer opportunistic infections than induction therapy with anti-interleukin-2 receptor antibodies.", "Pretreatment with the Arp2/3 inhibitor CK-666 affects lamelliopodia formation.", "The ureABIEFGH gene cluster is induced by nickel (II) ion.", "CX3CR1 on the Th2 cells suppresses airway inflammation.", "Tirasemtiv has no effect on fast-twitch muscle.", "NFAT4 activation requires IP3R-mediated Ca2+ mobilization.", "There is no association between HNF4A mutations and diabetes risks.", "Up-regulation of the p53 pathway and related molecular events casues cancer resistance and results in a significantly shortened lifespan marked by senescent cells and accelerated organismal aging."], "hard_negatives": ["Ethanol stress decreases the expression of IBP in bacteria.", "Helminths interfere with immune system control of macrophages activated by IL-4 favor Mycobacterium tuberculosis replication.", "Active H. pylori urease has a polymeric structure that compromises two subunits, UreA and UreB.", "Macropinocytosis contributes to a cell's supply of amino acids via the intracellular uptake of protein.", "High dietary calcium intakes are unnecessary for prevention of secondary hyperparathyroidism in subjects with 25(OH)D levels above 75 nmol/liter.", "Carriers of the alcohol aldehyde dehydrogenase deficiency mutation drink less that non-carries.", "Antibiotic induced alterations in the gut microbiome reduce resistance against Clostridium difficile", "Rapamycin decreases the concentration of triacylglycerols in fruit flies.", "Autophagy declines in aged organisms.", "Deamination of cytidine to uridine on the minus strand of viral DNA results in catastrophic G-to-A mutations in the viral genome."], "hard_negative": "Ethanol stress decreases the expression of IBP in bacteria."}
{"query_id": "399", "query_text": "Exposure to fine particulate air pollution is relate to anxiety prevalence.", "negative": "Increased vessel density along with a reduction in fibrosis decreases the efficacy of chemotherapy treatments.", "negatives": ["Increased vessel density along with a reduction in fibrosis decreases the efficacy of chemotherapy treatments.", "The arm density of TatAd complexes is due to structural rearrangements within Class1 TatAd complexes such as the 'charge zipper mechanism'.", "CX3CR1 on the Th2 cells suppresses airway inflammation.", "Articles published in open access format are less likely to be cited than traditional journals.", "Assembly of invadopodia is triggered by focal generation of phosphatidylinositol-3,4-biphosphate and the activation of the nonreceptor tyrosine kinase Src.", "Thigh-length graduated compression stockings (GCS) did not reduce deep vein thrombosis in patients admitted to hospital who are immobile because of acute stroke.", "Commelina yellow mottle virus' (ComYMV) genome consists of 7489 baise pairs.", "Febrile seizures reduce the threshold for development of epilepsy.", "Articles published in open access format are more likely to be cited than traditional journals.", "Ubiquitin ligase UBC13 generates a K63-linked polyubiquitin moiety at PCNA K164."], "hard_negatives": ["Exposure to fine particulate air pollution is relate to anxiety prevalence.", "Headaches are not correlated with cognitive impairment.", "Insomnia can be effectively treated with cognitive behavioral therapy.", "High levels of CRP reduces the risk of exacerbations in chronic obstructive pulmonary disease (COPD).", "Mice without IFN-\u03b3 or its receptor are resistant to EAM induced with \u03b1-MyHC/CFA.", "Non-invasive ventilation use should be decreased if there is inadequate response to conventional treatment.", "Epidemiological disease burden from noncommunicable diseases is more prevalent in low economic settings.", "Enhanced early production of inflammatory chemokines improves viral control in the lung.", "Hypoglycemia increases the risk of dementia.", "Asymptomatic visual impairment screening in elderly populations does not lead to improved vision."], "hard_negative": "Exposure to fine particulate air pollution is relate to anxiety prevalence."}
{"query_id": "410", "query_text": "Febrile seizures increase the threshold for development of epilepsy.", "negative": "Low expression of miR7a does represses target genes and exerts a biological function in ovaries.", "negatives": ["Low expression of miR7a does represses target genes and exerts a biological function in ovaries.", "Rapid up-regulation and higher basal expression of interferon-induced genes increase survival of granule cell neurons that are infected by West Nile virus.", "Individuals with low serum vitamin D concentrations have increased risk of multiple sclerosis.", "Alizarin forms hydrogen bonds with residues involved in PGAM1 substrate binding.", "Ly49Q directs the organization of neutrophil migration to inflammation sites by regulating membrane raft functions.", "Replacement of histone H2A with H2A.Z slows gene activation in yeasts by stabilizing +1 nucleosomes.", "Obesity is determined solely by environmental factors.", "Vitamin D deficiency effects the term of delivery.", "A total of 1,000 people in the UK are asymptomatic carriers of vCJD infection.", "Low nucleosome occupancy correlates with low methylation levels across species."], "hard_negatives": ["Febrile seizures increase the threshold for development of epilepsy.", "Febrile seizures reduce the threshold for development of epilepsy.", "Headaches are not correlated with cognitive impairment.", "Insomnia can be effectively treated with cognitive behavioral therapy.", "Hypoglycemia increases the risk of dementia.", "Sildenafil improves erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.", "Hypocretin neurones induce panicprone state in rats.", "Activation of PPM1D suppresses p53 function.", "Hypothalamic glutamate neurotransmission is crucial to energy balance.", "In young and middle-aged adults, current or remote uses of ADHD medications do not increase the risk of serious cardiovascular events."], "hard_negative": "Febrile seizures increase the threshold for development of epilepsy."}
{"query_id": "411", "query_text": "Febrile seizures reduce the threshold for development of epilepsy.", "negative": "Rapid up-regulation and higher basal expression of interferon-induced genes reduce survival of granule cell neurons that are infected by West Nile virus.", "negatives": ["Rapid up-regulation and higher basal expression of interferon-induced genes reduce survival of granule cell neurons that are infected by West Nile virus.", "High-sensitivity cardiac troponin T (HSCT-T) dosage may not be diagnostic if the onset of symptoms occurs less than 3 hours before acute myocardial injury (AMI).", "Autologous transplantation of mesenchymal stem cells causes a higher rate of opportunistic infections than induction therapy with anti-interleukin-2 receptor antibodies.", "Dexamethasone decreases risk of postoperative bleeding.", "Ubiquitin ligase UBC13 generates a K63-linked polyubiquitin moiety at PCNA K164.", "Primary cervical cancer screening with HPV detection has higher longitudinal sensitivity than conventional cytology to detect cervical intraepithelial neoplasia grade 2.", "The loss of the TET protein functions may have dire biological consequences, such as myeloid cancers.", "IFIT1 restricts viral replication by sequestrating mis-capped viral RNAs.", "Discrimination between the initiator and elongation tRNAs depends on the translation initiation factor IF3.", "Low nucleosome occupancy correlates with low methylation levels across species."], "hard_negatives": ["Febrile seizures reduce the threshold for development of epilepsy.", "Febrile seizures increase the threshold for development of epilepsy.", "Headaches are not correlated with cognitive impairment.", "Hypoglycemia increases the risk of dementia.", "Insomnia can be effectively treated with cognitive behavioral therapy.", "Sildenafil improves erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.", "Hypocretin neurones induce panicprone state in rats.", "Activation of PPM1D suppresses p53 function.", "In young and middle-aged adults, current or remote uses of ADHD medications do not increase the risk of serious cardiovascular events.", "Hypothalamic glutamate neurotransmission is crucial to energy balance."], "hard_negative": "Febrile seizures reduce the threshold for development of epilepsy."}
{"query_id": "415", "query_text": "Female carriers of the Apolipoprotein E4 (APOE4) allele have increased risk for dementia.", "negative": "Albendazole is used to treat lymphatic filariasis.", "negatives": ["Albendazole is used to treat lymphatic filariasis.", "Podocytes are motile and migrate in the presence of injury.", "CHEK2 is not associated with breast cancer.", "Insulin increases risk of severe kidney failure.", "Cell autonomous sex determination in somatic cells does not occur in Galliformes.", "Antiretroviral therapy reduces rates of tuberculosis across a broad range of CD4 strata.", "Inositol lipid 3-phosphatase PTEN converts Ptdlns(3,4)P 2 into phosphatidylinositol 4-phosphate.", "UCB T cells maintain high TCR diversity after transplantation.", "Birth-weight is positively associated with breast cancer.", "Occupancy of ribosomes by IncRNAs do not make functional peptides."], "hard_negatives": ["Female carriers of the Apolipoprotein E4 (APOE4) allele have increased risk for dementia.", "Hypoglycemia increases the risk of dementia.", "The risk of breast cancer among parous women increases with placental weight of pregnancies, and this association is strongest for premenopausal breast cancer.", "Women with a higher birth weight are more likely to develop breast cancer later in life.", "HNF4A mutations can cause diabetes in mutant carriers by the age of 14 years", "Birth-weight is positively associated with breast cancer.", "Carriers of the alcohol aldehyde dehydrogenase deficiency mutation drink less that non-carries.", "Asymptomatic visual impairment screening in elderly populations does not lead to improved vision.", "5% of perinatal mortality is due to low birth weight.", "There is no association between HNF4A mutations and diabetes risks."], "hard_negative": "Female carriers of the Apolipoprotein E4 (APOE4) allele have increased risk for dementia."}
{"query_id": "421", "query_text": "Flexible molecules experience greater steric hindrance in the tumor microenviroment than rigid molecules.", "negative": "N348I mutations cause resistance to zidovudine (AZT).", "negatives": ["N348I mutations cause resistance to zidovudine (AZT).", "CHEK2 is not associated with breast cancer.", "CX3CR1 on the Th2 cells promotes airway inflammation.", "The repair of Cas9-induced double strand breaks in human DNA is error-prone.", "Asymptomatic visual impairment screening in elderly populations does not lead to improved vision.", "NR5A2 is important in development of endometrial tissues.", "Taxation of sugar-sweetened beverages had no effect on the incidence rate of type II diabetes in India.", "Ultrasound guidance significantly raises the number of traumatic procedures when attempting needle insertion.", "T regulatory cells (tTregs) lacking \u03b1v\u03b28 are more adept at suppressing pathogenic T-cell responses during active inflammation.", "Mutant mice lacking SVCT2 have greatly increased ascorbic acid levels in both brain and adrenals."], "hard_negatives": ["Flexible molecules experience greater steric hindrance in the tumor microenviroment than rigid molecules.", "Nanoparticles can be targeted against specific cell types by incorporating aptamers into lipid nanoparticles.", "0-dimensional biomaterials show inductive properties.", "Venules have a thinner or absent smooth layer compared to arterioles.", "Increased vessel density along with a reduction in fibrosis decreases the efficacy of chemotherapy treatments.", "The genomic aberrations found in matasteses are very similar to those found in the primary tumor.", "Macrolides protect against myocardial infarction.", "Macrolides have no protective effect against myocardial infarction.", "Arterioles have a larger lumen diameter than venules.", "De novo assembly of sequence data has more specific contigs than unassembled sequence data."], "hard_negative": "Flexible molecules experience greater steric hindrance in the tumor microenviroment than rigid molecules."}
{"query_id": "431", "query_text": "FoxO3a activation in neuronal death is mediated by reactive oxygen species (ROS).", "negative": "A deficiency of vitamin B12 increases blood levels of homocysteine.", "negatives": ["A deficiency of vitamin B12 increases blood levels of homocysteine.", "CX3CR1 on the Th2 cells promotes T cell survival", "The single flash-evoked ERG b-wave is generated by activity of ON-bipolar cells.", "AIRE is expressed in some skin tumors.", "Hematopoietic Stem Cell purification reaches purity rate of up to 50%.", "Homozygous deletion of murine Sbds gene from osterix-expressing mesenchymal stem and progenitor cells (MPCs) prevents oxidative stress.", "Arterioles have a larger lumen diameter than venules.", "CX3CR1 on the Th2 cells suppresses airway inflammation.", "Normal expression of RUNX1 has tumor-promoting effects.", "Mitochondria are uninvolved in apoptosis."], "hard_negatives": ["FoxO3a activation in neuronal death is mediated by reactive oxygen species (ROS).", "The minor G allele of FOXO3 is related to more severe symptoms of Crohn's Disease.", "APOE4 expression in iPSC-derived neurons increases AlphaBeta production and tau phosphorylation, delaying GABA neuron degeneration.", "Modifying the epigenome in the brain affects the normal human aging process by affecting certain genes related to neurogenesis.", "APOE4 expression in iPSC-derived neurons increases AlphaBeta production and tau phosphorylation causing GABA neuron degeneration.", "NF2 (Merlin) causes phosphorylation and subsequent cytoplasmic sequestration of YAP in Drosophila by activating LATS1/2 kinases.", "ITAM phosphorylation prevents the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).", "TNFAIP3 is a tumor suppressor in glioblastoma.", "Leukemia associated Rho guanine nucleotide-exchange factor represses RhoA in response to SRC activation.", "Mice without IFN-\u03b3 or its receptor are resistant to EAM induced with \u03b1-MyHC/CFA."], "hard_negative": "FoxO3a activation in neuronal death is mediated by reactive oxygen species (ROS)."}
{"query_id": "436", "query_text": "Free histones are degraded by a Rad53-dependent mechanism once DNA has been replicated.", "negative": "Cells undergoing methionine restriction may activate miRNAs.", "negatives": ["Cells undergoing methionine restriction may activate miRNAs.", "Incidence rates of cervical cancer have increased due to nationwide screening programs based primarily on cytology to detect uterine cervical cancer.", "Mutant mice lacking SVCT2 have greatly increased ascorbic acid levels in both brain and adrenals.", "Activator-inhibitor pairs are provided dorsally by Admpchordin.", "The YAP1 and TEAD complex tanslocates into the nucleus where it interacts with transcription factors and DNA-binding proteins that modulate target gene transcription.", "The ureABIEFGH gene cluster is induced by nickel (II) ion.", "IRG1 has antiviral effects against neurotropic viruses.", "Active H. pylori urease has a polymeric structure that compromises two subunits, UreA and UreB.", "Cytosolic proteins bind to iron-responsive elements on mRNAs coding for DMT1. Cytosolic proteins bind to iron-responsive elements on mRNAs coding for proteins involved in iron uptake.", "A high microerythrocyte count raises vulnerability to severe anemia in homozygous alpha (+)- thalassemia trait subjects."], "hard_negatives": ["Free histones are degraded by a Rad53-dependent mechanism once DNA has been replicated.", "Histone demethylase recruitment and a transient decrease in histone methylation is necessary for ligand-dependent induction of transcription by nuclear receptors.", "Replacement of histone H2A with H2A.Z slows gene activation in yeasts by stabilizing +1 nucleosomes.", "The repair of Cas9-induced double strand breaks in human DNA is error-prone.", "S-nitrosylated GAPDH physiologically transnitrosylates histone deacetylases.", "Cytochrome c is released from the mitochondrial intermembrane space to cytosol during apoptosis.", "Low nucleosome occupancy correlates with low methylation levels across species.", "Many proteins in human cells can be post-translationally modified at lysine residues via acetylation.", "Most termination events in Okazaki fragments are sequence specific.", "Ribosomopathies have a low degree of cell and tissue specific pathology."], "hard_negative": "Free histones are degraded by a Rad53-dependent mechanism once DNA has been replicated."}
{"query_id": "437", "query_text": "Functional consequences of genomic alterations due to Myelodysplastic syndrome (MDS) are poorly understood due to the lack of an animal model.", "negative": "Gene expression does not vary appreciably across genetically identical cells.", "negatives": ["Gene expression does not vary appreciably across genetically identical cells.", "The YAP1 and TEAD complex tanslocates into the nucleus where it interacts with transcription factors and DNA-binding proteins that modulate target gene transcription.", "Thigh-length graduated compression stockings (GCS) did not reduce deep vein thrombosis in patients admitted to hospital who are immobile because of acute stroke.", "Ubiquitin ligase UBC13 generates a K63-linked polyubiquitin moiety at PCNA K164.", "Non-invasive ventilation use should be decreased if there is inadequate response to conventional treatment.", "Statins increase blood cholesterol.", "Cell autonomous sex determination in somatic cells occurs in Passeriformes.", "De novo assembly of sequence data has more specific contigs than unassembled sequence data.", "High levels of CRP reduces the risk of exacerbations in chronic obstructive pulmonary disease (COPD).", "The arm density of TatAd complexes is due to structural rearrangements within Class1 TatAd complexes such as the 'charge zipper mechanism'."], "hard_negatives": ["Functional consequences of genomic alterations due to Myelodysplastic syndrome (MDS) are poorly understood due to the lack of an animal model.", "The severity of cardiac involvement in amyloidosis can be described by the degree of transmurality of late gadolinium enhancement in MRI.", "Diabetic patients with acute coronary syndrome experience increased short-term and long-term risk for bleeding events.", "There is no association between HNF4A mutations and diabetes risks.", "Ribosomopathies have a low degree of cell and tissue specific pathology.", "CRP is not predictive of postoperative mortality following Coronary Artery Bypass Graft (CABG) surgery.", "Individuals with low serum vitamin D concentrations have increased risk of multiple sclerosis.", "Macrolides have no protective effect against myocardial infarction.", "A high microerythrocyte count raises vulnerability to severe anemia in homozygous alpha (+)- thalassemia trait subjects.", "The repair of Cas9-induced double strand breaks in human DNA is error-prone."], "hard_negative": "Functional consequences of genomic alterations due to Myelodysplastic syndrome (MDS) are poorly understood due to the lack of an animal model."}
{"query_id": "439", "query_text": "Fz/PCP-dependent Pk localizes to the anterior membrane of neuroectoderm cells during zebrafish neuralation", "negative": "The PRR MDA5 is a sensor of RNA virus infection.", "negatives": ["The PRR MDA5 is a sensor of RNA virus infection.", "In domesticated populations of Saccharomyces cerevisiae, whole chromosome aneuploidy is very uncommon.", "PDPN promotes efficient motility along stromal surfaces by activating the C-type lectin receptor to rearrange the actin cytoskeleton in dendritic cells.", "Birth-weight is positively associated with breast cancer.", "Many proteins in human cells can be post-translationally modified at lysine residues via acetylation.", "Up-regulation of the p53 pathway and related molecular events casues cancer resistance and results in a significantly shortened lifespan marked by senescent cells and accelerated organismal aging.", "Neutrophil extracellular traps (NETs) are released by ANCA-stimulated neutrophils.", "A deficiency of vitamin B12 increases blood levels of homocysteine.", "Autologous transplantation of mesenchymal stem cells causes a higher rate of opportunistic infections than induction therapy with anti-interleukin-2 receptor antibodies.", "Ivermectin is used to treat lymphatic filariasis."], "hard_negatives": ["Fz/PCP-dependent Pk localizes to the anterior membrane of neuroectoderm cells during zebrafish neuralation", "Fz/PCP-dependent Pk localizes to the anterior membrane of notochord cells during zebrafish neuralation.", "PDPN promotes efficient motility along stromal surfaces by activating the C-type lectin receptor to rearrange the actin cytoskeleton in dendritic cells.", "Ly49Q directs the organization of neutrophil migration to inflammation sites by regulating membrane raft functions.", "ITAM phosphorylation prevents the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).", "Synaptic activity enhances local release of brain derived neurotrophic factor from postsynaptic dendrites.", "The sliding activity of kinesin-8 protein Kip3 promotes bipolar spindle assembly.", "PKG-la plays an essential role in expression of pain hypersensitivity in PGK-la knockout mice.", "MicroRNA is involved in the regulation of Neural Stem Cell (NSC) differentiation and proliferation dynamic homeostasis", "Activator-inhibitor pairs are provided dorsally by Admpchordin."], "hard_negative": "Fz/PCP-dependent Pk localizes to the anterior membrane of neuroectoderm cells during zebrafish neuralation"}
{"query_id": "440", "query_text": "Fz/PCP-dependent Pk localizes to the anterior membrane of notochord cells during zebrafish neuralation.", "negative": "The locus rs647161 is associated with colorectal carcinoma.", "negatives": ["The locus rs647161 is associated with colorectal carcinoma.", "Helminths interfere with immune system control of macrophages activated by IL-4 favor Mycobacterium tuberculosis replication.", "Ly6C hi monocytes have a lower inflammatory capacity compared to their Ly6C lo counterparts.", "Angiotensin converting enzyme inhibitors are associated with increased risk for functional renal insufficiency.", "Leukemia associated Rho guanine nucleotide-exchange factor represses RhoA in response to SRC activation.", "Hyperfibrinogenemia increases rates of femoropopliteal bypass thrombosis.", "Deleting Raptor reduces G-CSF levels.", "Normal expression of RUNX1 has tumor-promoting effects.", "Mice defective for deoxyribonucleic acid (DNA) polymerase I (polI) reveal increased sensitivity to ionizing radiation (IR).", "The tip of the inner tube of the toxic type VI secretion system (T6SS) antibacterial effector in Escherichia coli (E. coli) carries toxic effector proteins."], "hard_negatives": ["Fz/PCP-dependent Pk localizes to the anterior membrane of notochord cells during zebrafish neuralation.", "Fz/PCP-dependent Pk localizes to the anterior membrane of neuroectoderm cells during zebrafish neuralation", "Ly49Q directs the organization of neutrophil migration to inflammation sites by regulating membrane raft functions.", "PDPN promotes efficient motility along stromal surfaces by activating the C-type lectin receptor to rearrange the actin cytoskeleton in dendritic cells.", "The sliding activity of kinesin-8 protein Kip3 promotes bipolar spindle assembly.", "Synaptic activity enhances local release of brain derived neurotrophic factor from postsynaptic dendrites.", "PKG-la plays an essential role in expression of pain hypersensitivity in PGK-la knockout mice.", "TCR/CD3 microdomains are a required to induce the immunologic synapse to activate T cells.", "ITAM phosphorylation prevents the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).", "Golli-deficient T-cells prefer to differentiate into an anergic phenotype in the adaptive immune response when there are increased levels of Ca2+ in the cytosol."], "hard_negative": "Fz/PCP-dependent Pk localizes to the anterior membrane of notochord cells during zebrafish neuralation."}
{"query_id": "443", "query_text": "GATA-3 is important for hematopoietic stem cell (HSC) function.", "negative": "Obesity is determined solely by environmental factors.", "negatives": ["Obesity is determined solely by environmental factors.", "The risk of breast cancer among parous women increases with placental weight of pregnancies, and this association is strongest for premenopausal breast cancer.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have increased risk for dementia.", "High-sensitivity cardiac troponin T (HSCT-T) dosage may not be diagnostic if the onset of symptoms occurs less than 3 hours before acute myocardial injury (AMI).", "Bariatric surgery has a positive impact on mental health.", "Mice without IFN-\u03b3 or its receptor are resistant to EAM induced with \u03b1-MyHC/CFA.", "Pyridostatin destabilizes the G - quadruplex in the telomeric region.", "Blocking the interaction between TDP-43 and respiratory complex I proteins ND3 and ND6 leads to increased TDP-43-induced neuronal loss.", "Crossover hot spots are not found within gene promoters in Saccharomyces cerevisiae.", "Up-regulation of the p53 pathway and related molecular events casues cancer resistance and results in a significantly shortened lifespan marked by senescent cells and accelerated organismal aging."], "hard_negatives": ["GATA-3 is important for hematopoietic stem cell (HSC) function.", "All hematopoietic stem cells segregate their chromosomes randomly.", "Hematopoietic Stem Cell purification reaches purity rate of up to 50%.", "ALDH1 expression is associated with better breast cancer outcomes.", "CRP is not predictive of postoperative mortality following Coronary Artery Bypass Graft (CABG) surgery.", "TNFAIP3 is a tumor suppressor in glioblastoma.", "The PPR MDA5 has two N-terminal CARD domains.", "NR5A2 is important in development of endometrial tissues.", "ALDH1 expression is associated with poorer prognosis in breast cancer.", "The PRR MDA5 has a central DExD/H RNA helices domain."], "hard_negative": "GATA-3 is important for hematopoietic stem cell (HSC) function."}
{"query_id": "452", "query_text": "Gene expression does not vary appreciably across genetically identical cells.", "negative": "Transplanted human glial progenitor cells are incapable of forming a neural network with host animals' neurons.", "negatives": ["Transplanted human glial progenitor cells are incapable of forming a neural network with host animals' neurons.", "Alizarin forms hydrogen bonds with residues involved in PGAM1 substrate binding.", "Suboptimal nutrition is not predictive of chronic disease", "Lack of clpC does not affect sporulation efficiency in Bacillus subtilis cells.", "Febrile seizures reduce the threshold for development of epilepsy.", "Bone marrow cells contribute to adult macrophage compartments.", "Carriers of the alcohol aldehyde dehydrogenase deficiency mutation drink less that non-carries.", "Enhanced early production of inflammatory chemokines improves viral control in the lung.", "Podocytes are motile and migrate in the presence of injury.", "Golli-deficient T-cells prefer to differentiate into an anergic phenotype in the adaptive immune response when there are increased levels of Ca2+ in the cytosol."], "hard_negatives": ["Gene expression does not vary appreciably across genetically identical cells.", "All hematopoietic stem cells segregate their chromosomes randomly.", "Low nucleosome occupancy correlates with low methylation levels across species.", "Breast cancer development is determined exclusively by genetic factors.", "Microarray results from culture-amplified mixtures of serotypes correlate poorly with microarray results from uncultured mixtures.", "Modifying the epigenome in the brain affects the normal human aging process by affecting certain genes related to neurogenesis.", "Ribosomopathies have a low degree of cell and tissue specific pathology.", "Macropinocytosis contributes to a cell's supply of amino acids via the intracellular uptake of protein.", "Transplanted human glial cells can differentiate within the host animal.", "Cellular aging closely links to an older appearance."], "hard_negative": "Gene expression does not vary appreciably across genetically identical cells."}
{"query_id": "475", "query_text": "Glycolysis is one of the primary glycometabolic pathways in cells.", "negative": "Proteins synthesized at the growth cone are ubiquitinated at a higher rate than proteins from the cell body.", "negatives": ["Proteins synthesized at the growth cone are ubiquitinated at a higher rate than proteins from the cell body.", "Mitochondria are uninvolved in apoptosis.", "Transplanted human glial cells can differentiate within the host animal.", "Integrating classroom-based collaborative learning with Web-based collaborative learning leads to subpar class performance", "Ethanol stress decreases the expression of IBP in bacteria.", "Smc5/6 engagment drives the activation of SUMO E3 ligase Mms21 by ATP-dependent remolding.", "APOE4 expression in iPSC-derived neurons increases AlphaBeta production and tau phosphorylation, delaying GABA neuron degeneration.", "Replacement of histone H2A with H2A.Z slows gene activation in yeasts by stabilizing +1 nucleosomes.", "Cellular aging closely links to an older appearance.", "The loss of the TET protein functions may have dire biological consequences, such as myeloid cancers."], "hard_negatives": ["Glycolysis is one of the primary glycometabolic pathways in cells.", "Macropinocytosis contributes to a cell's supply of amino acids via the intracellular uptake of protein.", "Bone marrow cells contribute to adult macrophage compartments.", "Mutations in G-Beta protein GNB2 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.", "IgA plasma cells that are specific for transglutaminase 2 accumulate in the duodenal mucosa on commencement of a gluten-free diet.", "Pleiotropic coupling of GLP-1R to intracellular effectors promotes distinct profiles of cellular signaling.", "Cytochrome c is released from the mitochondrial intermembrane space to cytosol during apoptosis.", "Mitochondria are uninvolved in apoptosis.", "Hypothalamic glutamate neurotransmission is crucial to energy balance.", "Proteins synthesized at the growth cone are ubiquitinated at a higher rate than proteins from the cell body."], "hard_negative": "Glycolysis is one of the primary glycometabolic pathways in cells."}
{"query_id": "478", "query_text": "Golli-deficient T-cells prefer to differentiate into an anergic phenotype in the adaptive immune response when there are increased levels of Ca2+ in the cytosol.", "negative": "Sildenafil improves erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.", "negatives": ["Sildenafil improves erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.", "Free histones are degraded by a Rad53-dependent mechanism once DNA has been replicated.", "Primary pro-inflammatory cytokines induce secondary pro- and anti-inflammatory mediators.", "Leuko-increased blood increases infectious complications in red blood cell transfusion.", "Lupus-prone mice infected with curliproducing bacteria have higher autoantibody titers compared to controls.", "LDL cholesterol has no involvement in the development of cardiovascular disease.", "Up-regulation of the p53 pathway and related molecular events casues cancer resistance and results in a significantly shortened lifespan marked by senescent cells and accelerated organismal aging.", "Epigenetic modulating agents (EMAs) modulate antitumor immune response in a cancer model system.", "The treatment of cancer patients with co-IR blockade precipitates adverse autoimmune events.", "cSMAC formation enhances weak ligand signalling."], "hard_negatives": ["Golli-deficient T-cells prefer to differentiate into an anergic phenotype in the adaptive immune response when there are increased levels of Ca2+ in the cytosol.", "Reduced responsiveness to interleukin-2 in regulatory T cells is associated with greater resistance to autoimmune diseases such as Type 1 Diabetes.", "T regulatory cells (tTregs) lacking \u03b1v\u03b28 are more adept at suppressing pathogenic T-cell responses during active inflammation.", "In adult tissue, most T cells are memory T cells.", "Mice that lack Interferon-\u03b3 or its receptor exhibit high resistance to experimental autoimmune myocarditis.", "Transplanted human glial progenitor cells are incapable of forming a neural network with host animals' neurons.", "TCR/CD3 microdomains are a required to induce the immunologic synapse to activate T cells.", "CX3CR1 on the Th2 cells impairs T cell survival", "ITAM phosphorylation prevents the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).", "CX3CR1 on the Th2 cells promotes T cell survival"], "hard_negative": "Golli-deficient T-cells prefer to differentiate into an anergic phenotype in the adaptive immune response when there are increased levels of Ca2+ in the cytosol."}
{"query_id": "491", "query_text": "HNF4A mutations can cause diabetes in mutant carriers by the age of 14 years", "negative": "Glycolysis is one of the primary glycometabolic pathways in cells.", "negatives": ["Glycolysis is one of the primary glycometabolic pathways in cells.", "Ubiquitin ligase UBC13 generates a K63-linked polyubiquitin moiety at PCNA K164.", "Discrimination between the initiator and elongation tRNAs depends on the translation initiation factor IF3.", "The relationship between a breast cancer patient's capacity to metabolize tamoxifen and treatment outcome is dependent on the patient's genetic make-up.", "TCR/CD3 microdomains are a required to induce the immunologic synapse to activate T cells.", "Cold exposure increases BAT recruitment.", "The risk of male prisoners harming themselves is ten times that of female prisoners.", "AIRE is expressed in some skin tumors.", "Autophagy declines in aged organisms.", "ITAM phosphorylation prevents the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR)."], "hard_negatives": ["HNF4A mutations can cause diabetes in mutant carriers by the age of 14 years", "There is no association between HNF4A mutations and diabetes risks.", "Carriers of the alcohol aldehyde dehydrogenase deficiency mutation drink less that non-carries.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have increased risk for dementia.", "A deficiency of vitamin B12 increases blood levels of homocysteine.", "Vitamin D deficiency is unrelated to birth weight.", "A high microerythrocyte count raises vulnerability to severe anemia in homozygous alpha (+)- thalassemia trait subjects.", "Hypertension is frequently observed in type 1 diabetes patients.", "Hypoglycemia increases the risk of dementia.", "Mutations in G-Beta protein GNB2 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway."], "hard_negative": "HNF4A mutations can cause diabetes in mutant carriers by the age of 14 years"}
{"query_id": "501", "query_text": "Headaches are not correlated with cognitive impairment.", "negative": "Cataract and trachoma are the primary cause of blindness in Southern Sudan.", "negatives": ["Cataract and trachoma are the primary cause of blindness in Southern Sudan.", "Cells undergoing methionine restriction may activate miRNAs.", "Pretreatment with the Arp2/3 inhibitor CK-666 affects lamelliopodia formation.", "Chenodeosycholic acid treatment reduces whole-body energy expenditure.", "PPAR-RXRs are inhibited by PPAR ligands.", "Cell autonomous sex determination in somatic cells does not occur in Galliformes.", "Mutations in G-Beta protein GNB2 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.", "Aspirin inhibits the production of PGE2.", "Ly6C hi monocytes have a lower inflammatory capacity than Ly6C lo monocytes.", "The myocardial lineage develops from cardiac progenitors of mesodermal origin."], "hard_negatives": ["Headaches are not correlated with cognitive impairment.", "Insomnia can be effectively treated with cognitive behavioral therapy.", "Febrile seizures reduce the threshold for development of epilepsy.", "Asymptomatic visual impairment screening in elderly populations does not lead to improved vision.", "Febrile seizures increase the threshold for development of epilepsy.", "Hypoglycemia increases the risk of dementia.", "Auditory entrainment is strengthened when people see congruent visual and auditory information.", "Hypertension is frequently observed in type 1 diabetes patients.", "In young and middle-aged adults, current or remote uses of ADHD medications do not increase the risk of serious cardiovascular events.", "Exposure to fine particulate air pollution is relate to anxiety prevalence."], "hard_negative": "Headaches are not correlated with cognitive impairment."}
{"query_id": "502", "query_text": "Healthcare delivery efficiency in crowded delivery centers is impaired by improving structural, logistical, and interpersonal elements.", "negative": "FoxO3a activation in neuronal death is mediated by reactive oxygen species (ROS).", "negatives": ["FoxO3a activation in neuronal death is mediated by reactive oxygen species (ROS).", "Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have a dramatic impact in reducing malaria transmission.", "In transgenic mice harboring green florescent protein under the control of the Sox2 promoter, less than ten percent of the cells with green florescent colocalize with cell proliferation markers.", "N348I mutations cause resistance to zidovudine (AZT).", "Pyridostatin destabilizes the G - quadruplex in the telomeric region.", "Tetraspanin-3 is a causative factor in the development of acute myelogenous leukemia", "Glycolysis is one of the primary glycometabolic pathways in cells.", "Increased microtubule acetylation repairs LRRK2 Roc-COR domain mutation induced locomotor deficits.", "Ly6C hi monocytes have a lower inflammatory capacity compared to their Ly6C lo counterparts.", "Recurrent mutations occur frequently within CTCF anchor sites adjacent to oncogenes."], "hard_negatives": ["Healthcare delivery efficiency in crowded delivery centers is impaired by improving structural, logistical, and interpersonal elements.", "Input from  mental and physical health care professionals is effective at decreasing homelessness.", "Teaching hospitals do not provide better care than non-teaching hospitals.", "The availability of safe places to study is not effective at decreasing homelessness.", "The availability of safe places to study is effective at decreasing homelessness.", "Integrating classroom-based collaborative learning with Web-based collaborative learning leads to subpar class performance", "Epidemiological disease burden from noncommunicable diseases is more prevalent in low economic settings.", "Bariatric surgery has a positive impact on mental health.", "Non-invasive ventilation use should be decreased if there is inadequate response to conventional treatment.", "Patients in stable partnerships have a faster progression from HIV to AIDS."], "hard_negative": "Healthcare delivery efficiency in crowded delivery centers is impaired by improving structural, logistical, and interpersonal elements."}
{"query_id": "507", "query_text": "Helminths interfere with immune system control of macrophages activated by IL-4 favor Mycobacterium tuberculosis replication.", "negative": "Metastatic colorectal cancer treated with a single agent fluoropyrimidines resulted in reduced efficacy and lower quality of life when compared with oxaliplatin-based chemotherapy in elderly patients.", "negatives": ["Metastatic colorectal cancer treated with a single agent fluoropyrimidines resulted in reduced efficacy and lower quality of life when compared with oxaliplatin-based chemotherapy in elderly patients.", "Stroke patients with prior use of direct oral anticoagulants have a lower risk of in-hospital mortality than stroke patients with prior use of warfarin.", "Macrolides protect against myocardial infarction.", "The PRR MDA5 is a sensor of RNA virus infection.", "The composition of myosin-II isoform switches from the polarizable B isoform to the more homogenous A isoform during hematopoietic differentiation.", "The myocardial lineage develops from cardiac progenitors of mesodermal origin.", "ADAR1 binds to Dicer to cleave pre-miRNA.", "ALDH1 expression is associated with better breast cancer outcomes.", "Epidemiological disease burden from noncommunicable diseases is more prevalent in low economic settings.", "Golli-deficient T-cells prefer to differentiate into an anergic phenotype in the adaptive immune response when there are increased levels of Ca2+ in the cytosol."], "hard_negatives": ["Helminths interfere with immune system control of macrophages activated by IL-4 favor Mycobacterium tuberculosis replication.", "New drugs for tuberculosis often do not penetrate the necrotic portion of a tuberculosis lesion in high concentrations.", "Antiretroviral therapy reduces rates of tuberculosis across a broad range of CD4 strata.", "Antibiotic induced alterations in the gut microbiome reduce resistance against Clostridium difficile", "Ethanol stress decreases the expression of IBP in bacteria.", "Deamination of cytidine to uridine on the minus strand of viral DNA results in catastrophic G-to-A mutations in the viral genome.", "Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have a dramatic impact in reducing malaria transmission.", "Active H. pylori urease has a polymeric structure that compromises two subunits, UreA and UreB.", "Basophils counteract disease development in patients with systemic lupus erythematosus (SLE).", "Mice that lack Interferon-\u03b3 or its receptor exhibit high resistance to experimental autoimmune myocarditis."], "hard_negative": "Helminths interfere with immune system control of macrophages activated by IL-4 favor Mycobacterium tuberculosis replication."}
{"query_id": "508", "query_text": "Hematopoietic Stem Cell purification reaches purity rate of up to 50%.", "negative": "Autologous transplantation of mesenchymal stem cells causes a higher rate of opportunistic infections than induction therapy with anti-interleukin-2 receptor antibodies.", "negatives": ["Autologous transplantation of mesenchymal stem cells causes a higher rate of opportunistic infections than induction therapy with anti-interleukin-2 receptor antibodies.", "Less than 10% of the gabonese children with Schimmelpenning-Feuerstein-Mims syndrome (SFM) had a plasma lactate of more than 5mmol/L.", "Auditory entrainment is strengthened when people see congruent visual and auditory information.", "PD-1 triggering on monocytes reduces IL-10 production by monocytes.", "The arm density of TatAd complexes is due to structural rearrangements within Class1 TatAd complexes such as the 'charge zipper mechanism'.", "Replacement of histone H2A with H2A.Z slows gene activation in yeasts by stabilizing +1 nucleosomes.", "Fz/PCP-dependent Pk localizes to the anterior membrane of notochord cells during zebrafish neuralation.", "Pyridostatin destabilizes the G - quadruplex in the telomeric region.", "Auditory entrainment is strengthened when people see congruent visual and auditory information.", "The relationship between a breast cancer patient's capacity to metabolize tamoxifen and treatment outcome is dependent on the patient's genetic make-up."], "hard_negatives": ["Hematopoietic Stem Cell purification reaches purity rate of up to 50%.", "All hematopoietic stem cells segregate their chromosomes randomly.", "GATA-3 is important for hematopoietic stem cell (HSC) function.", "Leuko-reduced blood reduces infectious complications in red blood cell transfusion.", "Leuko-increased blood increases infectious complications in red blood cell transfusion.", "High levels of CRP reduces the risk of exacerbations in chronic obstructive pulmonary disease (COPD).", "Peroxynitrite is required for nitration of TCR/CD8.", "Primary cervical cancer screening with HPV detection has higher longitudinal sensitivity than conventional cytology to detect cervical intraepithelial neoplasia grade 2.", "1,000 genomes project enables mapping of genetic sequence variation consisting of rare variants with larger penetrance effects than common variants.", "The US health care system can save up to $750 million if 7% of patients waiting for kidney transplants participate in the optimized national kidney paired donation program."], "hard_negative": "Hematopoietic Stem Cell purification reaches purity rate of up to 50%."}
{"query_id": "513", "query_text": "High cardiopulmonary fitness causes increased mortality rate.", "negative": "The deregulated and prolonged activation of monocytes has deleterious effects in inflammatory diseases.", "negatives": ["The deregulated and prolonged activation of monocytes has deleterious effects in inflammatory diseases.", "Febrile seizures increase the threshold for development of epilepsy.", "Venules have a larger lumen diameter than arterioles.", "Leuko-reduced blood reduces infectious complications in red blood cell transfusion.", "High levels of copeptin decrease risk of diabetes.", "Less than 10% of the gabonese children with Schimmelpenning-Feuerstein-Mims syndrome (SFM) had a plasma lactate of more than 5mmol/L.", "Ivermectin is used to treat onchocerciasis.", "ALDH1 expression is associated with poorer prognosis in breast cancer.", "The amount of publicly available DNA data doubles every 10 years.", "Microarray results from culture-amplified mixtures of serotypes correlate poorly with microarray results from uncultured mixtures."], "hard_negatives": ["High cardiopulmonary fitness causes increased mortality rate.", "Incidence of heart failure decreased by 10% in women since 1979.", "Obesity decreases life quality.", "5% of perinatal mortality is due to low birth weight.", "Insulin increases risk of severe kidney failure.", "CRP is not predictive of postoperative mortality following Coronary Artery Bypass Graft (CABG) surgery.", "Hypoglycemia increases the risk of dementia.", "Epidemiological disease burden from noncommunicable diseases is more prevalent in low economic settings.", "Diabetic patients with acute coronary syndrome experience increased short-term and long-term risk for bleeding events.", "Angiotensin converting enzyme inhibitors are associated with increased risk for functional renal insufficiency."], "hard_negative": "High cardiopulmonary fitness causes increased mortality rate."}
{"query_id": "514", "query_text": "High dietary calcium intakes are unnecessary for prevention of secondary hyperparathyroidism in subjects with 25(OH)D levels above 75 nmol/liter.", "negative": "Reduced responsiveness to interleukin-2 in regulatory T cells is associated with greater resistance to autoimmune diseases such as Type 1 Diabetes.", "negatives": ["Reduced responsiveness to interleukin-2 in regulatory T cells is associated with greater resistance to autoimmune diseases such as Type 1 Diabetes.", "The benefits of colchicine were achieved with effective widespread use of secondary prevention strategies such as high-dose statins.", "0-dimensional biomaterials show inductive properties.", "Alizarin forms hydrogen bonds with residues involved in PGAM1 substrate binding.", "The arm density of TatAd complexes is due to structural rearrangements within Class1 TatAd complexes such as the 'charge zipper mechanism'.", "N-terminal cleavage reduces success identifying transcription start sites.", "In mice, P. chabaudi parasites are able to proliferate faster early in infection when inoculated at lower numbers than when inoculated at high numbers.", "The availability of safe places to study is effective at decreasing homelessness.", "Epidemiological disease burden from noncommunicable diseases is more prevalent in low economic settings.", "Non-invasive ventilation use should be decreased if there is inadequate response to conventional treatment."], "hard_negatives": ["High dietary calcium intakes are unnecessary for prevention of secondary hyperparathyroidism in subjects with 25(OH)D levels above 75 nmol/liter.", "A deficiency of vitamin B12 increases blood levels of homocysteine.", "LDL cholesterol has no involvement in the development of cardiovascular disease.", "Chenodeosycholic acid treatment increases whole-body energy expenditure.", "Angiotensin converting enzyme inhibitors are associated with increased risk for functional renal insufficiency.", "Chenodeosycholic acid treatment reduces whole-body energy expenditure.", "High levels of copeptin decrease risk of diabetes.", "Vitamin D deficiency is unrelated to birth weight.", "Mutant mice lacking SVCT2 have greatly increased ascorbic acid levels in both brain and adrenals.", "Insulin increases risk of severe kidney failure."], "hard_negative": "High dietary calcium intakes are unnecessary for prevention of secondary hyperparathyroidism in subjects with 25(OH)D levels above 75 nmol/liter."}
{"query_id": "516", "query_text": "High levels of CRP reduces the risk of exacerbations in chronic obstructive pulmonary disease (COPD).", "negative": "The locus rs647161 is associated with colorectal carcinoma.", "negatives": ["The locus rs647161 is associated with colorectal carcinoma.", "Silencing of Bcl2 is important for the maintenance and progression of tumors.", "Polymeal nutrition reduces cardiovascular mortality.", "Omnivores produce less trimethylamine N-oxide from dietary I-carnitine than vegetarians.", "Leukemia associated Rho guanine nucleotide-exchange factor represses RhoA in response to SRC activation.", "Cells lacking clpC have a defect in sporulation efficiency in Bacillus subtilis.", "Glycolysis is one of the primary glycometabolic pathways in cells.", "Neutrophil extracellular traps (NETs) are released by ANCA-stimulated neutrophils.", "NF2 (Merlin) causes phosphorylation and subsequent cytoplasmic sequestration of YAP in Drosophila by activating LATS1/2 kinases.", "Microarray results from culture-amplified mixtures of serotypes correlate poorly with microarray results from uncultured mixtures."], "hard_negatives": ["High levels of CRP reduces the risk of exacerbations in chronic obstructive pulmonary disease (COPD).", "CRP is not predictive of postoperative mortality following Coronary Artery Bypass Graft (CABG) surgery.", "AMP-activated protein kinase (AMPK) activation increases inflammation-related fibrosis in the lungs.", "Diabetic patients with acute coronary syndrome experience increased short-term and long-term risk for bleeding events.", "Mice that lack Interferon-\u03b3 or its receptor exhibit high resistance to experimental autoimmune myocarditis.", "Exposure to fine particulate air pollution is relate to anxiety prevalence.", "LDL cholesterol has no involvement in the development of cardiovascular disease.", "Dexamethasone decreases risk of postoperative bleeding.", "Hypertension is frequently observed in type 1 diabetes patients.", "Antiretroviral therapy reduces rates of tuberculosis across a broad range of CD4 strata."], "hard_negative": "High levels of CRP reduces the risk of exacerbations in chronic obstructive pulmonary disease (COPD)."}
{"query_id": "517", "query_text": "High levels of copeptin decrease risk of diabetes.", "negative": "Increased vessel density along with a reduction in fibrosis decreases the efficacy of chemotherapy treatments.", "negatives": ["Increased vessel density along with a reduction in fibrosis decreases the efficacy of chemotherapy treatments.", "Ivermectin is used to treat lymphatic filariasis.", "High cardiopulmonary fitness causes increased mortality rate.", "The composition of myosin-II isoform switches from the polarizable B isoform to the more homogenous A isoform during hematopoietic differentiation.", "Cold exposure reduces BAT recruitment.", "Febrile seizures increase the threshold for development of epilepsy.", "Hypertension is frequently observed in type 1 diabetes patients.", "In mouse models, the loss of CSF1R facilitates MOZ-TIF2-induced leuekmogenesis.", "The PPR MDA5 has two N-terminal CARD domains.", "Autologous transplantation of mesenchymal stem cells has lower rates of rejection than induction therapy with anti-interleukin-2 receptor antibodies."], "hard_negatives": ["High levels of copeptin decrease risk of diabetes.", "Insulin increases risk of severe kidney failure.", "Hypertension is frequently observed in type 1 diabetes patients.", "In young and middle-aged adults, current or remote uses of ADHD medications do not increase the risk of serious cardiovascular events.", "High dietary calcium intakes are unnecessary for prevention of secondary hyperparathyroidism in subjects with 25(OH)D levels above 75 nmol/liter.", "LDL cholesterol has no involvement in the development of cardiovascular disease.", "Sildenafil improves erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.", "Headaches are not correlated with cognitive impairment.", "Dexamethasone decreases risk of postoperative bleeding.", "High levels of CRP reduces the risk of exacerbations in chronic obstructive pulmonary disease (COPD)."], "hard_negative": "High levels of copeptin decrease risk of diabetes."}
{"query_id": "521", "query_text": "High-sensitivity cardiac troponin T (HSCT-T) dosage may not be diagnostic if the onset of symptoms occurs less than 3 hours before acute myocardial injury (AMI).", "negative": "Ly49Q directs the organization of neutrophil migration to inflammation sites by regulating membrane raft functions.", "negatives": ["Ly49Q directs the organization of neutrophil migration to inflammation sites by regulating membrane raft functions.", "Active H. pylori urease has a polymeric structure that compromises two subunits, UreA and UreB.", "Individuals with low serum vitamin D concentrations have increased risk of multiple sclerosis.", "Tetraspanin-3 is a causative factor in the development of acute myelogenous leukemia", "Less than 10% of the gabonese children with Schimmelpenning-Feuerstein-Mims syndrome (SFM) had a plasma lactate of more than 5mmol/L.", "Cold exposure increases BAT recruitment.", "High dietary calcium intakes are unnecessary for prevention of secondary hyperparathyroidism in subjects with 25(OH)D levels above 75 nmol/liter.", "Taxation of sugar-sweetened beverages had no effect on the incidence rate of type II diabetes in India.", "Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have a dramatic impact in reducing malaria transmission.", "Cold exposure reduces BAT recruitment."], "hard_negatives": ["High-sensitivity cardiac troponin T (HSCT-T) dosage may not be diagnostic if the onset of symptoms occurs less than 3 hours before acute myocardial injury (AMI).", "The severity of cardiac involvement in amyloidosis can be described by the degree of transmurality of late gadolinium enhancement in MRI.", "Reduced responsiveness to interleukin-2 in regulatory T cells is associated with greater resistance to autoimmune diseases such as Type 1 Diabetes.", "CX3CR1 on the Th2 cells impairs T cell survival", "TCR/CD3 microdomains are a required to induce the immunologic synapse to activate T cells.", "T regulatory cells (tTregs) lacking \u03b1v\u03b28 are more adept at suppressing pathogenic T-cell responses during active inflammation.", "High dietary calcium intakes are unnecessary for prevention of secondary hyperparathyroidism in subjects with 25(OH)D levels above 75 nmol/liter.", "Golli-deficient T-cells prefer to differentiate into an anergic phenotype in the adaptive immune response when there are increased levels of Ca2+ in the cytosol.", "LDL cholesterol has no involvement in the development of cardiovascular disease.", "CX3CR1 on the Th2 cells promotes T cell survival"], "hard_negative": "High-sensitivity cardiac troponin T (HSCT-T) dosage may not be diagnostic if the onset of symptoms occurs less than 3 hours before acute myocardial injury (AMI)."}
{"query_id": "525", "query_text": "Histone demethylase recruitment and a transient decrease in histone methylation is necessary for ligand-dependent induction of transcription by nuclear receptors.", "negative": "Antiretroviral therapy reduces rates of tuberculosis across a broad range of CD4 strata.", "negatives": ["Antiretroviral therapy reduces rates of tuberculosis across a broad range of CD4 strata.", "Arterioles have a larger lumen diameter than venules.", "Incidence of heart failure decreased by 10% in women since 1979.", "Immune complex triggered cell death leads to extracellular release of neutrophil protein HMGB1.", "Breast cancer development is determined exclusively by genetic factors.", "Human T-lymphotropic virus type-I-associated myelopathy / tropical spastic paraparesis (HAM/TSP) patients produce Immunoglobulin G (IgG) antibodies which cross-react with an immunodominant epitope in Tax.", "Individuals with low serum vitamin D concentrations have increased risk of multiple sclerosis.", "Localization of PIN1 in the Arabidopsis embryo does not require VPS9a", "Women with a higher birth weight are more likely to develop breast cancer later in life.", "New drugs for tuberculosis often do not penetrate the necrotic portion of a tuberculosis lesion in high concentrations."], "hard_negatives": ["Histone demethylase recruitment and a transient decrease in histone methylation is necessary for ligand-dependent induction of transcription by nuclear receptors.", "Free histones are degraded by a Rad53-dependent mechanism once DNA has been replicated.", "S-nitrosylated GAPDH physiologically transnitrosylates histone deacetylases.", "Replacement of histone H2A with H2A.Z slows gene activation in yeasts by stabilizing +1 nucleosomes.", "N-terminal cleavage increases success identifying transcription start sites.", "N-terminal cleavage reduces success identifying transcription start sites.", "ITAM phosphorylation prevents the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).", "Low nucleosome occupancy correlates with low methylation levels across species.", "Discrimination between the initiator and elongation tRNAs depends on the translation initiation factor IF3.", "CR is associated with higher methylation age."], "hard_negative": "Histone demethylase recruitment and a transient decrease in histone methylation is necessary for ligand-dependent induction of transcription by nuclear receptors."}
{"query_id": "527", "query_text": "Homozygous deletion of murine Sbds gene from osterix-expressing mesenchymal stem and progenitor cells (MPCs) prevents oxidative stress.", "negative": "PD-1 triggering on monocytes reduces IL-10 production by monocytes.", "negatives": ["PD-1 triggering on monocytes reduces IL-10 production by monocytes.", "Chenodeosycholic acid treatment increases whole-body energy expenditure.", "Combining phosphatidylinositide 3-kinase and MEK 1/2 inhibitors is effective at treating KRAS mutant tumors.", "N348I mutations cause resistance to zidovudine (AZT).", "Primary pro-inflammatory cytokines induce secondary pro- and anti-inflammatory mediators.", "Pseudogene PTENP1 regulates the expression of PTEN by functioning as an miRNA decoy.", "CX3CR1 on the Th2 cells impairs T cell survival", "In domesticated populations of Saccharomyces cerevisiae, whole chromosome aneuploidy is very uncommon.", "Ethanol stress decreases the expression of IBP in bacteria.", "Errors in peripheral IV drug administration are most common during bolus administration and multiple-step medicine preparations."], "hard_negatives": ["Homozygous deletion of murine Sbds gene from osterix-expressing mesenchymal stem and progenitor cells (MPCs) prevents oxidative stress.", "Human T-lymphotropic virus type-I-associated myelopathy / tropical spastic paraparesis (HAM/TSP) patients produce Immunoglobulin G (IgG) antibodies which cross-react with an immunodominant epitope in Tax.", "Autologous transplantation of mesenchymal stem cells causes fewer opportunistic infections than induction therapy with anti-interleukin-2 receptor antibodies.", "Autologous transplantation of mesenchymal stem cells causes a higher rate of opportunistic infections than induction therapy with anti-interleukin-2 receptor antibodies.", "Autologous transplantation of mesenchymal stem cells has lower rates of rejection than induction therapy with anti-interleukin-2 receptor antibodies.", "Infection of human T-cell lymphotropic virus type 1 is most frequent in individuals of African origin.", "N348I mutations cause resistance to zidovudine (AZT).", "A high microerythrocyte count raises vulnerability to severe anemia in homozygous alpha (+)- thalassemia trait subjects.", "Deamination of cytidine to uridine on the minus strand of viral DNA results in catastrophic G-to-A mutations in the viral genome.", "Up-regulation of the p53 pathway and related molecular events casues cancer resistance and results in a significantly shortened lifespan marked by senescent cells and accelerated organismal aging."], "hard_negative": "Homozygous deletion of murine Sbds gene from osterix-expressing mesenchymal stem and progenitor cells (MPCs) prevents oxidative stress."}
{"query_id": "528", "query_text": "Human T-lymphotropic virus type-I-associated myelopathy / tropical spastic paraparesis (HAM/TSP) patients produce Immunoglobulin G (IgG) antibodies which cross-react with an immunodominant epitope in Tax.", "negative": "Mutant mice lacking SVCT2 have greatly increased ascorbic acid levels in both brain and adrenals.", "negatives": ["Mutant mice lacking SVCT2 have greatly increased ascorbic acid levels in both brain and adrenals.", "IFIT1 restricts viral replication by sequestrating mis-capped viral RNAs.", "The loss of the TET protein functions may have dire biological consequences, such as myeloid cancers.", "Activator-inhibitor pairs are provided dorsally by Admpchordin.", "Synaptic activity enhances local release of brain derived neurotrophic factor from postsynaptic dendrites.", "The extracellular domain of TMEM27 is cleaved in human beta cells.", "Less than 10% of the gabonese children with Schimmelpenning-Feuerstein-Mims syndrome (SFM) had a plasma lactate of more than 5mmol/L.", "Mercaptopurine is anabolized into the inactive methylmercaptopurine by thiopurine methyltrasnferase (TPMT).", "Modifying the epigenome in the brain affects the normal human aging process by affecting certain genes related to neurogenesis.", "TNFAIP3 is a tumor suppressor in glioblastoma."], "hard_negatives": ["Human T-lymphotropic virus type-I-associated myelopathy / tropical spastic paraparesis (HAM/TSP) patients produce Immunoglobulin G (IgG) antibodies which cross-react with an immunodominant epitope in Tax.", "Infection of human T-cell lymphotropic virus type 1 is most frequent in individuals of African origin.", "Tetraspanin-3 is a causative factor in the development of acute myelogenous leukemia", "Mice that lack Interferon-\u03b3 or its receptor exhibit high resistance to experimental autoimmune myocarditis.", "Homozygous deletion of murine Sbds gene from osterix-expressing mesenchymal stem and progenitor cells (MPCs) prevents oxidative stress.", "Functional consequences of genomic alterations due to Myelodysplastic syndrome (MDS) are poorly understood due to the lack of an animal model.", "Upregulation of mosGCTL-1 is induced upon infection with West Nile virus.", "A high microerythrocyte count raises vulnerability to severe anemia in homozygous alpha (+)- thalassemia trait subjects.", "Cataract and trachoma are the primary cause of blindness in Southern Sudan.", "Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have a dramatic impact in reducing malaria transmission."], "hard_negative": "Human T-lymphotropic virus type-I-associated myelopathy / tropical spastic paraparesis (HAM/TSP) patients produce Immunoglobulin G (IgG) antibodies which cross-react with an immunodominant epitope in Tax."}
{"query_id": "532", "query_text": "Hyperfibrinogenemia decreases rates of femoropopliteal bypass thrombosis.", "negative": "Non-invasive ventilation use should be decreased if there is inadequate response to conventional treatment.", "negatives": ["Non-invasive ventilation use should be decreased if there is inadequate response to conventional treatment.", "A high microerythrocyte count raises vulnerability to severe anemia in homozygous alpha (+)- thalassemia trait subjects.", "Insomnia can be effectively treated with cognitive behavioral therapy.", "NFAT4 activation requires IP3R-mediated Ca2+ mobilization.", "Integrating classroom-based collaborative learning with Web-based collaborative learning leads to subpar class performance", "Golli-deficient T-cells prefer to differentiate into an anergic phenotype in the adaptive immune response when there are increased levels of Ca2+ in the cytosol.", "The single flash-evoked ERG b-wave is generated by activity of ON-bipolar cells.", "The ureABIEFGH gene cluster is induced by nickel (II) ion.", "Sildenafil improves erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.", "Hematopoietic Stem Cell purification reaches purity rate of up to 50%."], "hard_negatives": ["Hyperfibrinogenemia decreases rates of femoropopliteal bypass thrombosis.", "Hyperfibrinogenemia increases rates of femoropopliteal bypass thrombosis.", "Diabetic patients with acute coronary syndrome experience increased short-term and long-term risk for bleeding events.", "The risk of breast cancer among parous women increases with placental weight of pregnancies, and this association is strongest for premenopausal breast cancer.", "CRP is not predictive of postoperative mortality following Coronary Artery Bypass Graft (CABG) surgery.", "Dexamethasone decreases risk of postoperative bleeding.", "Hypertension is frequently observed in type 1 diabetes patients.", "Thigh-length graduated compression stockings (GCS) did not reduce deep vein thrombosis in patients admitted to hospital who are immobile because of acute stroke.", "Mice that lack Interferon-\u03b3 or its receptor exhibit high resistance to experimental autoimmune myocarditis.", "Hypoglycemia increases the risk of dementia."], "hard_negative": "Hyperfibrinogenemia decreases rates of femoropopliteal bypass thrombosis."}
{"query_id": "533", "query_text": "Hyperfibrinogenemia increases rates of femoropopliteal bypass thrombosis.", "negative": "Chronic aerobic exercise alters endothelial function, improving vasodilating mechanisms mediated by NO.", "negatives": ["Chronic aerobic exercise alters endothelial function, improving vasodilating mechanisms mediated by NO.", "Macropinocytosis contributes to a cell's supply of amino acids via the intracellular uptake of protein.", "FoxO3a activation in neuronal death is mediated by reactive oxygen species (ROS).", "Blocking the interaction between TDP-43 and respiratory complex I proteins ND3 and ND6 leads to increased TDP-43-induced neuronal loss.", "Bone marrow cells contribute to adult macrophage compartments.", "Healthcare delivery efficiency in crowded delivery centers is impaired by improving structural, logistical, and interpersonal elements.", "CR is associated with higher methylation age.", "Macropinocytosis contributes to a cell's supply of amino acids via the intracellular uptake of protein.", "Transplanted human glial cells can differentiate within the host animal.", "PPAR-RXRs are inhibited by PPAR ligands."], "hard_negatives": ["Hyperfibrinogenemia increases rates of femoropopliteal bypass thrombosis.", "Hyperfibrinogenemia decreases rates of femoropopliteal bypass thrombosis.", "Diabetic patients with acute coronary syndrome experience increased short-term and long-term risk for bleeding events.", "The risk of breast cancer among parous women increases with placental weight of pregnancies, and this association is strongest for premenopausal breast cancer.", "Dexamethasone decreases risk of postoperative bleeding.", "Hypertension is frequently observed in type 1 diabetes patients.", "Hypoglycemia increases the risk of dementia.", "CRP is not predictive of postoperative mortality following Coronary Artery Bypass Graft (CABG) surgery.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have increased risk for dementia.", "Mice that lack Interferon-\u03b3 or its receptor exhibit high resistance to experimental autoimmune myocarditis."], "hard_negative": "Hyperfibrinogenemia increases rates of femoropopliteal bypass thrombosis."}
{"query_id": "535", "query_text": "Hypertension is frequently observed in type 1 diabetes patients.", "negative": "Microarray results from culture-amplified mixtures of serotypes correlate poorly with microarray results from uncultured mixtures.", "negatives": ["Microarray results from culture-amplified mixtures of serotypes correlate poorly with microarray results from uncultured mixtures.", "Vitamin D deficiency effects the term of delivery.", "Carriers of the alcohol aldehyde dehydrogenase deficiency mutation drink less that non-carries.", "Macropinocytosis contributes to a cell's supply of amino acids via the intracellular uptake of protein.", "Active H. pylori urease has a polymeric structure that compromises two subunits, UreA and UreB.", "Hypothalamic glutamate neurotransmission is crucial to energy balance.", "Cells undergoing methionine restriction may activate miRNAs.", "Exposure to fine particulate air pollution is relate to anxiety prevalence.", "Hypertension is frequently observed in type 1 diabetes patients.", "Women with a higher birth weight are more likely to develop breast cancer later in life."], "hard_negatives": ["Hypertension is frequently observed in type 1 diabetes patients.", "Insulin increases risk of severe kidney failure.", "Headaches are not correlated with cognitive impairment.", "High levels of copeptin decrease risk of diabetes.", "Diabetic patients with acute coronary syndrome experience increased short-term and long-term risk for bleeding events.", "In young and middle-aged adults, current or remote uses of ADHD medications do not increase the risk of serious cardiovascular events.", "Hypoglycemia increases the risk of dementia.", "Taxation of sugar-sweetened beverages had no effect on the incidence rate of type II diabetes in India.", "Angiotensin converting enzyme inhibitors are associated with increased risk for functional renal insufficiency.", "HNF4A mutations can cause diabetes in mutant carriers by the age of 14 years"], "hard_negative": "Hypertension is frequently observed in type 1 diabetes patients."}
{"query_id": "536", "query_text": "Hypocretin neurones induce panicprone state in rats.", "negative": "Diabetic patients with acute coronary syndrome experience increased short-term and long-term risk for bleeding events.", "negatives": ["Diabetic patients with acute coronary syndrome experience increased short-term and long-term risk for bleeding events.", "Monoclonal antibody targeting of N-cadherin inhibits metastasis.", "ALDH1 expression is associated with poorer prognosis in breast cancer.", "Autologous transplantation of mesenchymal stem cells has lower rates of rejection than induction therapy with anti-interleukin-2 receptor antibodies.", "Asymptomatic visual impairment screening in elderly populations does not lead to improved vision.", "The relationship between a breast cancer patient's capacity to metabolize tamoxifen and treatment outcome is dependent on the patient's genetic make-up.", "GATA-3 is important for hematopoietic stem cell (HSC) function.", "The deregulated and prolonged activation of monocytes has deleterious effects in inflammatory diseases.", "The combination of H3K4me3 and H3K79me2 is found in quiescent hair follicle stem cells.", "Free histones are degraded by a Rad53-dependent mechanism once DNA has been replicated."], "hard_negatives": ["Hypocretin neurones induce panicprone state in rats.", "Mice that lack Interferon-\u03b3 or its receptor exhibit high resistance to experimental autoimmune myocarditis.", "Febrile seizures increase the threshold for development of epilepsy.", "Febrile seizures reduce the threshold for development of epilepsy.", "Hypothalamic glutamate neurotransmission is crucial to energy balance.", "Exposure to fine particulate air pollution is relate to anxiety prevalence.", "The single flash-evoked ERG b-wave is generated by activity of ON-bipolar cells.", "Mice without IFN-\u03b3 or its receptor are resistant to EAM induced with \u03b1-MyHC/CFA.", "IRG1 has antiviral effects against neurotropic viruses.", "FoxO3a activation in neuronal death is mediated by reactive oxygen species (ROS)."], "hard_negative": "Hypocretin neurones induce panicprone state in rats."}
{"query_id": "539", "query_text": "Hypoglycemia increases the risk of dementia.", "negative": "The PRR MDA5 is a sensor of RNA virus infection.", "negatives": ["The PRR MDA5 is a sensor of RNA virus infection.", "Febrile seizures reduce the threshold for development of epilepsy.", "Macropinocytosis contributes to a cell's supply of amino acids via the intracellular uptake of protein.", "CCL19 is absent within dLNs.", "Metastatic colorectal cancer treated with a single agent fluoropyrimidines resulted in reduced efficacy and lower quality of life when compared with oxaliplatin-based chemotherapy in elderly patients.", "Aspirin inhibits the production of PGE2.", "The ureABIEFGH gene cluster is induced by nickel (II) ion.", "Cytosolic proteins bind to iron-responsive elements on mRNAs coding for DMT1. Cytosolic proteins bind to iron-responsive elements on mRNAs coding for proteins involved in iron uptake.", "NOX2-independent pathways can generate peroxynitrite by reacting with nitrogen intermediates.", "Bone marrow cells contribute to adult macrophage compartments."], "hard_negatives": ["Hypoglycemia increases the risk of dementia.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have increased risk for dementia.", "Headaches are not correlated with cognitive impairment.", "Febrile seizures reduce the threshold for development of epilepsy.", "Asymptomatic visual impairment screening in elderly populations does not lead to improved vision.", "Antiretroviral therapy reduces rates of tuberculosis across a broad range of CD4 strata.", "Insomnia can be effectively treated with cognitive behavioral therapy.", "Febrile seizures increase the threshold for development of epilepsy.", "Hypertension is frequently observed in type 1 diabetes patients.", "A total of 1,000 people in the UK are asymptomatic carriers of vCJD infection."], "hard_negative": "Hypoglycemia increases the risk of dementia."}
{"query_id": "540", "query_text": "Hypothalamic glutamate neurotransmission is crucial to energy balance.", "negative": "Pleiotropic coupling of GLP-1R to intracellular effectors promotes distinct profiles of cellular signaling.", "negatives": ["Pleiotropic coupling of GLP-1R to intracellular effectors promotes distinct profiles of cellular signaling.", "Autologous transplantation of mesenchymal stem cells has lower rates of rejection than induction therapy with anti-interleukin-2 receptor antibodies.", "The PRR MDA5 is a sensor of RNA virus infection.", "5% of perinatal mortality is due to low birth weight.", "Neutrophil extracellular traps (NETs) are released by ANCA-stimulated neutrophils.", "N-terminal cleavage increases success identifying transcription start sites.", "The deregulated and prolonged activation of monocytes has deleterious effects in inflammatory diseases.", "Aspirin inhibits the production of PGE2.", "Integrating classroom-based collaborative learning with Web-based collaborative learning leads to subpar class performance", "The PRR MDA5 is a sensor of RNA virus infection."], "hard_negatives": ["Hypothalamic glutamate neurotransmission is crucial to energy balance.", "Synaptic activity enhances local release of brain derived neurotrophic factor from postsynaptic dendrites.", "Headaches are not correlated with cognitive impairment.", "Modifying the epigenome in the brain affects the normal human aging process by affecting certain genes related to neurogenesis.", "AMP-activated protein kinase (AMPK) activation increases inflammation-related fibrosis in the lungs.", "Auditory entrainment is strengthened when people see congruent visual and auditory information.", "FoxO3a activation in neuronal death is mediated by reactive oxygen species (ROS).", "aPKCz causes tumour enhancement by affecting glutamine metabolism.", "Statins increase blood cholesterol.", "Glycolysis is one of the primary glycometabolic pathways in cells."], "hard_negative": "Hypothalamic glutamate neurotransmission is crucial to energy balance."}
{"query_id": "544", "query_text": "IFIT1 restricts viral replication by sequestrating mis-capped viral RNAs.", "negative": "A deficiency of vitamin B12 increases blood levels of homocysteine.", "negatives": ["A deficiency of vitamin B12 increases blood levels of homocysteine.", "Venules have a larger lumen diameter than arterioles.", "Cytochrome c is released from the mitochondrial intermembrane space to cytosol during apoptosis.", "Gene expression does not vary appreciably across genetically identical cells.", "FoxO3a activation in neuronal death is mediated by reactive oxygen species (ROS).", "The availability of safe places to study is not effective at decreasing homelessness.", "Homozygous deletion of murine Sbds gene from osterix-expressing mesenchymal stem and progenitor cells (MPCs) prevents oxidative stress.", "The combination of H3K4me3 and H3K79me2 is found in quiescent hair follicle stem cells.", "Mutations in G-Beta protein GNB2 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.", "Cells lacking clpC have a defect in sporulation efficiency in Bacillus subtilis."], "hard_negatives": ["IFIT1 restricts viral replication by sequestrating mis-capped viral RNAs.", "Pseudogene PTENP1 regulates the expression of PTEN by functioning as an miRNA decoy.", "IRG1 has antiviral effects against neurotropic viruses.", "The repair of Cas9-induced double strand breaks in human DNA is error-prone.", "Cells undergoing methionine restriction may activate miRNAs.", "Localization of PIN1 in the Arabidopsis embryo does not require VPS9a", "Deamination of cytidine to uridine on the minus strand of viral DNA results in catastrophic G-to-A mutations in the viral genome.", "ADAR1 binds to Dicer to cleave pre-miRNA.", "Occupancy of ribosomes by IncRNAs do not make functional peptides.", "Discrimination between the initiator and elongation tRNAs depends on the translation initiation factor IF3."], "hard_negative": "IFIT1 restricts viral replication by sequestrating mis-capped viral RNAs."}
{"query_id": "549", "query_text": "IRG1 has antiviral effects against neurotropic viruses.", "negative": "Cold exposure increases BAT recruitment.", "negatives": ["Cold exposure increases BAT recruitment.", "The minor G allele of FOXO3 is related to more severe symptoms of Crohn's Disease.", "N-terminal cleavage increases success identifying transcription start sites.", "Mutant mice lacking SVCT2 have greatly increased ascorbic acid levels in both brain and adrenals.", "Localization of PIN1 in the Arabidopsis embryo does not require VPS9a", "Low expression of miR7a exerts a biological function in testis.", "Hypertension is frequently observed in type 1 diabetes patients.", "Helminths interfere with immune system control of macrophages activated by IL-4 favor Mycobacterium tuberculosis replication.", "Ly6C hi monocytes have a lower inflammatory capacity compared to their Ly6C lo counterparts.", "ADAR1 binds to Dicer to cleave pre-miRNA."], "hard_negatives": ["IRG1 has antiviral effects against neurotropic viruses.", "Mice that lack Interferon-\u03b3 or its receptor exhibit high resistance to experimental autoimmune myocarditis.", "TNFAIP3 is a tumor suppressor in glioblastoma.", "The treatment of cancer patients with co-IR blockade precipitates adverse autoimmune events.", "The treatment of cancer patients with co-IR blockade does not cause any adverse autoimmune events.", "IFIT1 restricts viral replication by sequestrating mis-capped viral RNAs.", "Arginine 90 in p150n is important for interaction with EB1.", "APOE4 expression in iPSC-derived neurons increases AlphaBeta production and tau phosphorylation, delaying GABA neuron degeneration.", "Tetraspanin-3 is a causative factor in the development of acute myelogenous leukemia", "Tumor necrosis factor alpha (TNF-\u03b1) and interleukin-1 (IL-1) are pro-inflammatory cytokines that inhibit IL-6 and IL-10."], "hard_negative": "IRG1 has antiviral effects against neurotropic viruses."}
{"query_id": "551", "query_text": "ITAM phosphorylation prevents the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).", "negative": "Low nucleosome occupancy correlates with low methylation levels across species.", "negatives": ["Low nucleosome occupancy correlates with low methylation levels across species.", "PDPN promotes efficient motility along stromal surfaces by activating the C-type lectin receptor to rearrange the actin cytoskeleton in dendritic cells.", "Lack of clpC does not affect sporulation efficiency in Bacillus subtilis cells.", "MicroRNA is involved in the regulation of Neural Stem Cell (NSC) differentiation and proliferation dynamic homeostasis", "The amount of publicly available DNA data doubles every 10 years.", "Statins increase blood cholesterol.", "In adult tissue, most T cells are memory T cells.", "The risk of breast cancer among parous women increases with placental weight of pregnancies, and this association is strongest for premenopausal breast cancer.", "1,000 genomes project enables mapping of genetic sequence variation consisting of rare variants with larger penetrance effects than common variants.", "De novo assembly of sequence data has more specific contigs than unassembled sequence data."], "hard_negatives": ["ITAM phosphorylation prevents the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).", "TCR/CD3 microdomains are a required to induce the immunologic synapse to activate T cells.", "Blocking the interaction between TDP-43 and respiratory complex I proteins ND3 and ND6 leads to increased TDP-43-induced neuronal loss.", "mTORC2 regulates intracellular cysteine levels through xCT inhibition.", "Reduced responsiveness to interleukin-2 in regulatory T cells is associated with greater resistance to autoimmune diseases such as Type 1 Diabetes.", "CX3CR1 on the Th2 cells promotes T cell survival", "CX3CR1 on the Th2 cells impairs T cell survival", "Low expression of miR7a exerts a biological function in testis.", "NF2 (Merlin) causes phosphorylation and subsequent cytoplasmic sequestration of YAP in Drosophila by activating LATS1/2 kinases.", "PDPN promotes efficient motility along stromal surfaces by activating the C-type lectin receptor to rearrange the actin cytoskeleton in dendritic cells."], "hard_negative": "ITAM phosphorylation prevents the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR)."}
{"query_id": "552", "query_text": "IgA plasma cells that are specific for transglutaminase 2 accumulate in the duodenal mucosa on commencement of a gluten-free diet.", "negative": "The availability of safe places to study is effective at decreasing homelessness.", "negatives": ["The availability of safe places to study is effective at decreasing homelessness.", "Auditory entrainment is strengthened when people see congruent visual and auditory information.", "IFIT1 restricts viral replication by sequestrating mis-capped viral RNAs.", "ALDH1 expression is associated with poorer prognosis in breast cancer.", "Chenodeosycholic acid treatment increases whole-body energy expenditure.", "Cells lacking clpC have a defect in sporulation efficiency in Bacillus subtilis.", "Pleiotropic coupling of GLP-1R to intracellular effectors promotes distinct profiles of cellular signaling.", "Blocking the interaction between TDP-43 and respiratory complex I proteins ND3 and ND6 leads to increased TDP-43-induced neuronal loss.", "High-sensitivity cardiac troponin T (HSCT-T) dosage may not be diagnostic if the onset of symptoms occurs less than 3 hours before acute myocardial injury (AMI).", "Activation of PPM1D suppresses p53 function."], "hard_negatives": ["IgA plasma cells that are specific for transglutaminase 2 accumulate in the duodenal mucosa on commencement of a gluten-free diet.", "Mutations in G-Beta protein GNB2 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.", "Pyridostatin destabilizes the G - quadruplex in the telomeric region.", "Glycolysis is one of the primary glycometabolic pathways in cells.", "PDPN promotes efficient motility along stromal surfaces by activating the C-type lectin receptor to rearrange the actin cytoskeleton in dendritic cells.", "Arginine 90 in p150n is important for interaction with EB1.", "Alizarin forms hydrogen bonds with residues involved in PGAM1 substrate binding.", "Ubiquitin ligase UBC13 generates a K63-linked polyubiquitin moiety at PCNA K164.", "Deamination of cytidine to uridine on the minus strand of viral DNA results in catastrophic G-to-A mutations in the viral genome.", "NF2 (Merlin) causes phosphorylation and subsequent cytoplasmic sequestration of YAP in Drosophila by activating LATS1/2 kinases."], "hard_negative": "IgA plasma cells that are specific for transglutaminase 2 accumulate in the duodenal mucosa on commencement of a gluten-free diet."}
{"query_id": "554", "query_text": "Immune complex triggered cell death leads to extracellular release of neutrophil protein HMGB1.", "negative": "Febrile seizures reduce the threshold for development of epilepsy.", "negatives": ["Febrile seizures reduce the threshold for development of epilepsy.", "Upregulation of mosGCTL-1 is induced upon infection with West Nile virus.", "A total of 1,000 people in the UK are asymptomatic carriers of vCJD infection.", "PD-1 triggering on monocytes reduces IL-10 production by monocytes.", "Cold exposure reduces BAT recruitment.", "Teaching hospitals do not provide better care than non-teaching hospitals.", "Autologous transplantation of mesenchymal stem cells has lower rates of rejection than induction therapy with anti-interleukin-2 receptor antibodies.", "Ly49Q directs the organization of neutrophil migration to inflammation sites by regulating membrane raft functions.", "Exposure to fine particulate air pollution is relate to anxiety prevalence.", "Human T-lymphotropic virus type-I-associated myelopathy / tropical spastic paraparesis (HAM/TSP) patients produce Immunoglobulin G (IgG) antibodies which cross-react with an immunodominant epitope in Tax."], "hard_negatives": ["Immune complex triggered cell death leads to extracellular release of neutrophil protein HMGB1.", "Immune responses result in the development of inflammatory Th17 cells and anti-inflammatory iTregs.", "The center of the granuloma in an immune cell induces a pro-inflammatory immune response.", "Mitochondria are uninvolved in apoptosis.", "CX3CR1 on the Th2 cells impairs T cell survival", "The deregulated and prolonged activation of monocytes has deleterious effects in inflammatory diseases.", "ITAM phosphorylation prevents the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).", "Neutrophil extracellular traps (NETs) are released by ANCA-stimulated neutrophils.", "Cytochrome c is released from the mitochondrial intermembrane space to cytosol during apoptosis.", "Upregulation of mosGCTL-1 is induced upon infection with West Nile virus."], "hard_negative": "Immune complex triggered cell death leads to extracellular release of neutrophil protein HMGB1."}
{"query_id": "560", "query_text": "Immune responses result in the development of inflammatory Th17 cells and anti-inflammatory iTregs.", "negative": "Articles published in open access format are more likely to be cited than traditional journals.", "negatives": ["Articles published in open access format are more likely to be cited than traditional journals.", "ADAR1 binds to Dicer to cleave pre-miRNA.", "UCB T cells maintain high TCR diversity after transplantation.", "Epidemiological disease burden from noncommunicable diseases is more prevalent in low economic settings.", "1,000 genomes project enables mapping of genetic sequence variation consisting of rare variants with larger penetrance effects than common variants.", "PKG-la plays an essential role in expression of pain hypersensitivity in PGK-la knockout mice.", "Ivermectin is used to treat onchocerciasis.", "ITAM phosphorylation prevents the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).", "Leuko-increased blood increases infectious complications in red blood cell transfusion.", "In young and middle-aged adults, current or remote uses of ADHD medications do not increase the risk of serious cardiovascular events."], "hard_negatives": ["Immune responses result in the development of inflammatory Th17 cells and anti-inflammatory iTregs.", "Primary pro-inflammatory cytokines induce secondary pro- and anti-inflammatory mediators.", "T regulatory cells (tTregs) lacking \u03b1v\u03b28 are more adept at suppressing pathogenic T-cell responses during active inflammation.", "Reduced responsiveness to interleukin-2 in regulatory T cells is associated with greater resistance to autoimmune diseases such as Type 1 Diabetes.", "Tumor necrosis factor alpha (TNF-\u03b1) and interleukin-1 (IL-1) are pro-inflammatory cytokines that inhibit IL-6 and IL-10.", "CX3CR1 on the Th2 cells promotes airway inflammation.", "CX3CR1 on the Th2 cells suppresses airway inflammation.", "Enhanced early production of inflammatory chemokines improves viral control in the lung.", "Immune complex triggered cell death leads to extracellular release of neutrophil protein HMGB1.", "Crosstalk between dendritic cells (DCs) and innate lymphoid cells (ILCs) is important in the regulation of intestinal homeostasis."], "hard_negative": "Immune responses result in the development of inflammatory Th17 cells and anti-inflammatory iTregs."}
{"query_id": "569", "query_text": "In adult tissue, most T cells are memory T cells.", "negative": "Monoclonal antibody targeting of N-cadherin inhibits metastasis.", "negatives": ["Monoclonal antibody targeting of N-cadherin inhibits metastasis.", "Modifying the epigenome in the brain affects the normal human aging process by affecting certain genes related to neurogenesis.", "PGE 2 promotes intestinal tumor growth by altering the expression of tumor suppressing and DNA repair genes.", "Arterioles have a larger lumen diameter than venules.", "T regulatory cells (tTregs) lacking \u03b1v\u03b28 are more adept at suppressing pathogenic T-cell responses during active inflammation.", "The severity of cardiac involvement in amyloidosis can be described by the degree of transmurality of late gadolinium enhancement in MRI.", "Active H. pylori urease has a polymeric structure that compromises two subunits, UreA and UreB.", "Crosstalk between dendritic cells (DCs) and innate lymphoid cells (ILCs) is important in the regulation of intestinal homeostasis.", "Primary pro-inflammatory cytokines induce secondary pro- and anti-inflammatory mediators.", "Deleting Raptor reduces G-CSF levels."], "hard_negatives": ["In adult tissue, most T cells are memory T cells.", "T regulatory cells (tTregs) lacking \u03b1v\u03b28 are more adept at suppressing pathogenic T-cell responses during active inflammation.", "Transferred UCB T cells acquire a memory-like phenotype in recipients.", "TCR/CD3 microdomains are a required to induce the immunologic synapse to activate T cells.", "CX3CR1 on the Th2 cells promotes T cell survival", "Golli-deficient T-cells prefer to differentiate into an anergic phenotype in the adaptive immune response when there are increased levels of Ca2+ in the cytosol.", "Reduced responsiveness to interleukin-2 in regulatory T cells is associated with greater resistance to autoimmune diseases such as Type 1 Diabetes.", "UCB T cells maintain high TCR diversity after transplantation.", "CX3CR1 on the Th2 cells impairs T cell survival", "UCB T cells reduce TCR diversity after transplantation."], "hard_negative": "In adult tissue, most T cells are memory T cells."}
{"query_id": "575", "query_text": "In domesticated populations of Saccharomyces cerevisiae, whole chromosome aneuploidy is very uncommon.", "negative": "There is no association between HNF4A mutations and diabetes risks.", "negatives": ["There is no association between HNF4A mutations and diabetes risks.", "Obesity decreases life quality.", "Cold exposure reduces BAT recruitment.", "Microarray results from culture-amplified mixtures of serotypes correlate poorly with microarray results from uncultured mixtures.", "cSMAC formation enhances weak ligand signalling.", "Ly6C hi monocytes have a lower inflammatory capacity than Ly6C lo monocytes.", "Radioiodine treatment of non-toxic multinodular goitre reduces thyroid volume.", "During the primary early antibody response activated B cells migrate toward the inner-and outer paracortical areas where oxysterol accumulation is generated by stromal cells.", "High-sensitivity cardiac troponin T (HSCT-T) dosage may not be diagnostic if the onset of symptoms occurs less than 3 hours before acute myocardial injury (AMI).", "Ivermectin is used to treat onchocerciasis."], "hard_negatives": ["In domesticated populations of Saccharomyces cerevisiae, whole chromosome aneuploidy is very uncommon.", "Crossover hot spots are not found within gene promoters in Saccharomyces cerevisiae.", "Functional consequences of genomic alterations due to Myelodysplastic syndrome (MDS) are poorly understood due to the lack of an animal model.", "All hematopoietic stem cells segregate their chromosomes randomly.", "Low nucleosome occupancy correlates with low methylation levels across species.", "The repair of Cas9-induced double strand breaks in human DNA is error-prone.", "Anthrax spores can be disposed of easily after they are dispersed.", "Cell autonomous sex determination in somatic cells does not occur in Galliformes.", "Gene expression does not vary appreciably across genetically identical cells.", "Cells lacking clpC have a defect in sporulation efficiency in Bacillus subtilis."], "hard_negative": "In domesticated populations of Saccharomyces cerevisiae, whole chromosome aneuploidy is very uncommon."}
{"query_id": "577", "query_text": "In mice, P. chabaudi parasites are able to proliferate faster early in infection when inoculated at lower numbers than when inoculated at high numbers.", "negative": "Statins decrease blood cholesterol.", "negatives": ["Statins decrease blood cholesterol.", "Cell autonomous sex determination in somatic cells occurs in Passeriformes.", "Low expression of miR7a exerts a biological function in testis.", "Fz/PCP-dependent Pk localizes to the anterior membrane of notochord cells during zebrafish neuralation.", "Normal expression of RUNX1 has tumor-promoting effects.", "Antiretroviral therapy reduces rates of tuberculosis across a broad range of CD4 strata.", "Tetraspanin-3 is a causative factor in the development of acute myelogenous leukemia", "Localization of PIN1 in the roots of Arabidopsis does not require VPS9a", "Replacement of histone H2A with H2A.Z slows gene activation in yeasts by stabilizing +1 nucleosomes.", "Taxation of sugar-sweetened beverages had no effect on the incidence rate of type II diabetes in India."], "hard_negatives": ["In mice, P. chabaudi parasites are able to proliferate faster early in infection when inoculated at lower numbers than when inoculated at high numbers.", "New drugs for tuberculosis often do not penetrate the necrotic portion of a tuberculosis lesion in high concentrations.", "Only a minority of cells survive development after differentiation into stress-resistant spores.", "Podocytes are motile and migrate in the presence of injury.", "Helminths interfere with immune system control of macrophages activated by IL-4 favor Mycobacterium tuberculosis replication.", "Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have a dramatic impact in reducing malaria transmission.", "Lupus-prone mice infected with curliproducing bacteria have higher autoantibody titers compared to controls.", "Infection of human T-cell lymphotropic virus type 1 is most frequent in individuals of African origin.", "Anthrax spores can be disposed of easily after they are dispersed.", "Antibiotic induced alterations in the gut microbiome reduce resistance against Clostridium difficile"], "hard_negative": "In mice, P. chabaudi parasites are able to proliferate faster early in infection when inoculated at lower numbers than when inoculated at high numbers."}
{"query_id": "578", "query_text": "In mouse models, the loss of CSF1R facilitates MOZ-TIF2-induced leuekmogenesis.", "negative": "Immune complex triggered cell death leads to extracellular release of neutrophil protein HMGB1.", "negatives": ["Immune complex triggered cell death leads to extracellular release of neutrophil protein HMGB1.", "The PRR MDA5 has a central DExD/H RNA helices domain.", "Cellular aging closely links to an older appearance.", "The PRR MDA5 is a sensor of RNA virus infection.", "Leukemia associated Rho guanine nucleotide-exchange factor represses RhoA in response to SRC activation.", "N348I mutations cause resistance to zidovudine (AZT).", "Ribosomopathies have a low degree of cell and tissue specific pathology.", "TNFAIP3 is a tumor suppressor in glioblastoma.", "Human T-lymphotropic virus type-I-associated myelopathy / tropical spastic paraparesis (HAM/TSP) patients produce Immunoglobulin G (IgG) antibodies which cross-react with an immunodominant epitope in Tax.", "Epigenetic modulating agents (EMAs) modulate antitumor immune response in a cancer model system."], "hard_negatives": ["In mouse models, the loss of CSF1R facilitates MOZ-TIF2-induced leuekmogenesis.", "Deleting Raptor reduces G-CSF levels.", "mTORC2 regulates intracellular cysteine levels through xCT inhibition.", "Mutant mice lacking SVCT2 have greatly increased ascorbic acid levels in both brain and adrenals.", "Ly49Q directs the organization of neutrophil migration to inflammation sites by regulating membrane raft functions.", "cSMAC formation enhances weak ligand signalling.", "NF2 (Merlin) prevents phosphorylation and subsequent cytoplasmic sequestration of YAP in Drosophila.", "NF2 (Merlin) causes phosphorylation and subsequent cytoplasmic sequestration of YAP in Drosophila by activating LATS1/2 kinases.", "Lymphadenopathy is observed in knockin mouse lacking the SHP-2 MAPK pathway.", "FoxO3a activation in neuronal death is mediated by reactive oxygen species (ROS)."], "hard_negative": "In mouse models, the loss of CSF1R facilitates MOZ-TIF2-induced leuekmogenesis."}
{"query_id": "587", "query_text": "In transgenic mice harboring green florescent protein under the control of the Sox2 promoter, less than ten percent of the cells with green florescent colocalize with cell proliferation markers.", "negative": "The treatment of cancer patients with co-IR blockade precipitates adverse autoimmune events.", "negatives": ["The treatment of cancer patients with co-IR blockade precipitates adverse autoimmune events.", "Mice that lack Interferon-\u03b3 or its receptor exhibit high resistance to experimental autoimmune myocarditis.", "AMP-activated protein kinase (AMPK) activation increases inflammation-related fibrosis in the lungs.", "Up-regulation of the p53 pathway and related molecular events casues cancer resistance and results in a significantly shortened lifespan marked by senescent cells and accelerated organismal aging.", "The DdrB protein from Deinococcus radiodurans is an alternative SSB.", "Replacement of histone H2A with H2A.Z slows gene activation in yeasts by stabilizing +1 nucleosomes.", "Occupancy of ribosomes by IncRNAs mirror 5 0-UTRs", "AMP-activated protein kinase (AMPK) activation increases inflammation-related fibrosis in the lungs.", "Cellular aging closely links to an older appearance.", "Gene expression does not vary appreciably across genetically identical cells."], "hard_negatives": ["In transgenic mice harboring green florescent protein under the control of the Sox2 promoter, less than ten percent of the cells with green florescent colocalize with cell proliferation markers.", "The extracellular domain of TMEM27 is cleaved in human beta cells.", "Cytosolic proteins bind to iron-responsive elements on mRNAs coding for DMT1. Cytosolic proteins bind to iron-responsive elements on mRNAs coding for proteins involved in iron uptake.", "CHEK2 is not associated with breast cancer.", "AMP-activated protein kinase (AMPK) activation increases inflammation-related fibrosis in the lungs.", "ALDH1 expression is associated with poorer prognosis in breast cancer.", "PDPN promotes efficient motility along stromal surfaces by activating the C-type lectin receptor to rearrange the actin cytoskeleton in dendritic cells.", "The combination of H3K4me3 and H3K79me2 is found in quiescent hair follicle stem cells.", "NF2 (Merlin) causes phosphorylation and subsequent cytoplasmic sequestration of YAP in Drosophila by activating LATS1/2 kinases.", "ALDH1 expression is associated with better breast cancer outcomes."], "hard_negative": "In transgenic mice harboring green florescent protein under the control of the Sox2 promoter, less than ten percent of the cells with green florescent colocalize with cell proliferation markers."}
{"query_id": "589", "query_text": "In young and middle-aged adults, current or remote uses of ADHD medications do not increase the risk of serious cardiovascular events.", "negative": "Replacement of histone H2A with H2A.Z slows gene activation in yeasts by stabilizing +1 nucleosomes.", "negatives": ["Replacement of histone H2A with H2A.Z slows gene activation in yeasts by stabilizing +1 nucleosomes.", "0-dimensional biomaterials show inductive properties.", "Immune responses result in the development of inflammatory Th17 cells and anti-inflammatory iTregs.", "IFIT1 restricts viral replication by sequestrating mis-capped viral RNAs.", "Autophagy declines in aged organisms.", "Macropinocytosis contributes to a cell's supply of amino acids via the intracellular uptake of protein.", "Taxation of sugar-sweetened beverages had no effect on the incidence rate of type II diabetes in India.", "Silencing of Bcl2 is important for the maintenance and progression of tumors.", "Cells lacking clpC have a defect in sporulation efficiency in Bacillus subtilis.", "TCR/CD3 microdomains are a required to induce the immunologic synapse to activate T cells."], "hard_negatives": ["In young and middle-aged adults, current or remote uses of ADHD medications do not increase the risk of serious cardiovascular events.", "Insomnia can be effectively treated with cognitive behavioral therapy.", "Diabetic patients with acute coronary syndrome experience increased short-term and long-term risk for bleeding events.", "Headaches are not correlated with cognitive impairment.", "Asymptomatic visual impairment screening in elderly populations does not lead to improved vision.", "Sildenafil improves erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.", "Stroke patients with prior use of direct oral anticoagulants have a lower risk of in-hospital mortality than stroke patients with prior use of warfarin.", "Dexamethasone decreases risk of postoperative bleeding.", "High levels of copeptin decrease risk of diabetes.", "Hypertension is frequently observed in type 1 diabetes patients."], "hard_negative": "In young and middle-aged adults, current or remote uses of ADHD medications do not increase the risk of serious cardiovascular events."}
{"query_id": "593", "query_text": "Incidence of heart failure decreased by 10% in women since 1979.", "negative": "The center of the granuloma in an immune cell induces a pro-inflammatory immune response.", "negatives": ["The center of the granuloma in an immune cell induces a pro-inflammatory immune response.", "Tetraspanin-3 is a causative factor in the development of acute myelogenous leukemia", "Epigenetic modulating agents (EMAs) modulate antitumor immune response in a cancer model system.", "N348I mutations cause resistance to zidovudine (AZT).", "Silencing of Bcl2 is important for the maintenance and progression of tumors.", "ALDH1 expression is associated with better breast cancer outcomes.", "PPAR-RXRs are inhibited by PPAR ligands.", "0-dimensional biomaterials show inductive properties.", "Primary cervical cancer screening with HPV detection has higher longitudinal sensitivity than conventional cytology to detect cervical intraepithelial neoplasia grade 2.", "PKG-la plays an essential role in expression of pain hypersensitivity in PGK-la knockout mice."], "hard_negatives": ["Incidence of heart failure decreased by 10% in women since 1979.", "Women with a higher birth weight are more likely to develop breast cancer later in life.", "High cardiopulmonary fitness causes increased mortality rate.", "5% of perinatal mortality is due to low birth weight.", "Incidence rates of cervical cancer have decreased.", "CRP is not predictive of postoperative mortality following Coronary Artery Bypass Graft (CABG) surgery.", "Insulin increases risk of severe kidney failure.", "The risk of breast cancer among parous women increases with placental weight of pregnancies, and this association is strongest for premenopausal breast cancer.", "Diabetic patients with acute coronary syndrome experience increased short-term and long-term risk for bleeding events.", "The US health care system can save up to $750 million if 7% of patients waiting for kidney transplants participate in the optimized national kidney paired donation program."], "hard_negative": "Incidence of heart failure decreased by 10% in women since 1979."}
{"query_id": "597", "query_text": "Incidence rates of cervical cancer have decreased.", "negative": "Deletion of \u03b1v\u03b28 does not result in a spontaneous inflammatory phenotype.", "negatives": ["Deletion of \u03b1v\u03b28 does not result in a spontaneous inflammatory phenotype.", "ALDH1 expression is associated with poorer prognosis in breast cancer.", "Hypothalamic glutamate neurotransmission is crucial to energy balance.", "AIRE is expressed in some skin tumors.", "T regulatory cells (tTregs) lacking \u03b1v\u03b28 are more adept at suppressing pathogenic T-cell responses during active inflammation.", "Macrolides protect against myocardial infarction.", "The single flash-evoked ERG b-wave is generated by activity of ON-bipolar cells.", "The center of the granuloma in an immune cell induces a pro-inflammatory immune response.", "Leuko-increased blood increases infectious complications in red blood cell transfusion.", "Venules have a thinner or absent smooth layer compared to arterioles."], "hard_negatives": ["Incidence rates of cervical cancer have decreased.", "Incidence rates of cervical cancer have increased due to nationwide screening programs based primarily on cytology to detect uterine cervical cancer.", "Women with a higher birth weight are more likely to develop breast cancer later in life.", "The risk of breast cancer among parous women increases with placental weight of pregnancies, and this association is strongest for premenopausal breast cancer.", "Primary cervical cancer screening with HPV detection has higher longitudinal sensitivity than conventional cytology to detect cervical intraepithelial neoplasia grade 2.", "5% of perinatal mortality is due to low birth weight.", "Birth-weight is positively associated with breast cancer.", "Breast cancer development is determined exclusively by genetic factors.", "Incidence of heart failure decreased by 10% in women since 1979.", "A total of 1,000 people in the UK are asymptomatic carriers of vCJD infection."], "hard_negative": "Incidence rates of cervical cancer have decreased."}
{"query_id": "598", "query_text": "Incidence rates of cervical cancer have increased due to nationwide screening programs based primarily on cytology to detect uterine cervical cancer.", "negative": "p16INK4A accumulation is  linked to an abnormal wound response caused by the microinvasive step of advanced Oral Potentially Malignant Lesions (OPMLs).", "negatives": ["p16INK4A accumulation is  linked to an abnormal wound response caused by the microinvasive step of advanced Oral Potentially Malignant Lesions (OPMLs).", "Enhanced early production of inflammatory chemokines improves viral control in the lung.", "Cell autonomous sex determination in somatic cells occurs in Passeriformes.", "A high microerythrocyte count raises vulnerability to severe anemia in homozygous alpha (+)- thalassemia trait subjects.", "Headaches are not correlated with cognitive impairment.", "Pyridostatin destabilizes the G - quadruplex in the telomeric region.", "Transferred UCB T cells acquire a memory-like phenotype in recipients.", "Proteins synthesized at the growth cone are ubiquitinated at a higher rate than proteins from the cell body.", "Articles published in open access format are more likely to be cited than traditional journals.", "Ribosomopathies have a low degree of cell and tissue specific pathology."], "hard_negatives": ["Incidence rates of cervical cancer have increased due to nationwide screening programs based primarily on cytology to detect uterine cervical cancer.", "Incidence rates of cervical cancer have decreased.", "Primary cervical cancer screening with HPV detection has higher longitudinal sensitivity than conventional cytology to detect cervical intraepithelial neoplasia grade 2.", "Women with a higher birth weight are more likely to develop breast cancer later in life.", "The risk of breast cancer among parous women increases with placental weight of pregnancies, and this association is strongest for premenopausal breast cancer.", "Breast cancer development is determined exclusively by genetic factors.", "Birth-weight is positively associated with breast cancer.", "5% of perinatal mortality is due to low birth weight.", "A total of 1,000 people in the UK are asymptomatic carriers of vCJD infection.", "The relationship between a breast cancer patient's capacity to metabolize tamoxifen and treatment outcome is dependent on the patient's genetic make-up."], "hard_negative": "Incidence rates of cervical cancer have increased due to nationwide screening programs based primarily on cytology to detect uterine cervical cancer."}
{"query_id": "613", "query_text": "Increased microtubule acetylation repairs LRRK2 Roc-COR domain mutation induced locomotor deficits.", "negative": "Bariatric surgery has a positive impact on mental health.", "negatives": ["Bariatric surgery has a positive impact on mental health.", "Venules have a thinner or absent smooth layer compared to arterioles.", "Rapamycin decreases the concentration of triacylglycerols in fruit flies.", "All hematopoietic stem cells segregate their chromosomes randomly.", "The PPR MDA5 has two N-terminal CARD domains.", "Mutations in G-Beta protein GNB2 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.", "Microarray results from culture-amplified mixtures of serotypes correlate poorly with microarray results from uncultured mixtures.", "The sliding activity of kinesin-8 protein Kip3 promotes bipolar spindle assembly.", "Crosstalk between dendritic cells (DCs) and innate lymphoid cells (ILCs) is important in the regulation of intestinal homeostasis.", "AMP-activated protein kinase (AMPK) activation increases inflammation-related fibrosis in the lungs."], "hard_negatives": ["Increased microtubule acetylation repairs LRRK2 Roc-COR domain mutation induced locomotor deficits.", "ITAM phosphorylation prevents the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).", "CX3CR1 on the Th2 cells impairs T cell survival", "mTORC2 regulates intracellular cysteine levels through xCT inhibition.", "The sliding activity of kinesin-8 protein Kip3 promotes bipolar spindle assembly.", "PPAR-RXRs can be activated by PPAR ligands.", "FoxO3a activation in neuronal death is mediated by reactive oxygen species (ROS).", "CX3CR1 on the Th2 cells promotes T cell survival", "NF2 (Merlin) causes phosphorylation and subsequent cytoplasmic sequestration of YAP in Drosophila by activating LATS1/2 kinases.", "ADAR1 binds to Dicer to cleave pre-miRNA."], "hard_negative": "Increased microtubule acetylation repairs LRRK2 Roc-COR domain mutation induced locomotor deficits."}
{"query_id": "619", "query_text": "Increased vessel density along with a reduction in fibrosis decreases the efficacy of chemotherapy treatments.", "negative": "The PRR MDA5 is a sensor of RNA virus infection.", "negatives": ["The PRR MDA5 is a sensor of RNA virus infection.", "TCR/CD3 microdomains are a required to induce the immunologic synapse to activate T cells.", "Normal expression of RUNX1 has tumor-promoting effects.", "Patients in stable partnerships have a faster progression from HIV to AIDS.", "Albendazole is used to treat lymphatic filariasis.", "Crossover hot spots are not found within gene promoters in Saccharomyces cerevisiae.", "Rapid phosphotransfer rates govern fidelity in two component systems", "Deamination of cytidine to uridine on the minus strand of viral DNA results in catastrophic G-to-A mutations in the viral genome.", "Varenicline monotherapy is more effective after 12 weeks of treatment compared to combination nicotine replacement therapies with varenicline or bupropion.", "FoxO3a activation in neuronal death is mediated by reactive oxygen species (ROS)."], "hard_negatives": ["Increased vessel density along with a reduction in fibrosis decreases the efficacy of chemotherapy treatments.", "AMP-activated protein kinase (AMPK) activation increases inflammation-related fibrosis in the lungs.", "Albendazole is used to treat lymphatic filariasis.", "Angiotensin converting enzyme inhibitors are associated with increased risk for functional renal insufficiency.", "Ivermectin is used to treat lymphatic filariasis.", "Flexible molecules experience greater steric hindrance in the tumor microenviroment than rigid molecules.", "The center of the granuloma in an immune cell induces a pro-inflammatory immune response.", "New drugs for tuberculosis often do not penetrate the necrotic portion of a tuberculosis lesion in high concentrations.", "Enhanced early production of inflammatory chemokines improves viral control in the lung.", "Leuko-increased blood increases infectious complications in red blood cell transfusion."], "hard_negative": "Increased vessel density along with a reduction in fibrosis decreases the efficacy of chemotherapy treatments."}
{"query_id": "623", "query_text": "Individuals with low serum vitamin D concentrations have increased risk of multiple sclerosis.", "negative": "Transplanted human glial cells can differentiate within the host animal.", "negatives": ["Transplanted human glial cells can differentiate within the host animal.", "Articles published in open access format are less likely to be cited than traditional journals.", "The risk of male prisoners harming themselves is ten times that of female prisoners.", "Antiretroviral therapy reduces rates of tuberculosis across a broad range of CD4 strata.", "Cell autonomous sex determination in somatic cells does not occur in Galliformes.", "NF2 (Merlin) causes phosphorylation and subsequent cytoplasmic sequestration of YAP in Drosophila by activating LATS1/2 kinases.", "A total of 1,000 people in the UK are asymptomatic carriers of vCJD infection.", "Carriers of the alcohol aldehyde dehydrogenase deficiency mutation drink less that non-carries.", "MicroRNA is involved in the regulation of Neural Stem Cell (NSC) differentiation and proliferation dynamic homeostasis", "Helminths interfere with immune system control of macrophages activated by IL-4 favor Mycobacterium tuberculosis replication."], "hard_negatives": ["Individuals with low serum vitamin D concentrations have increased risk of multiple sclerosis.", "Vitamin D deficiency is unrelated to birth weight.", "Antiretroviral therapy reduces rates of tuberculosis across a broad range of CD4 strata.", "A deficiency of vitamin B12 increases blood levels of homocysteine.", "Hypoglycemia increases the risk of dementia.", "Women with a higher birth weight are more likely to develop breast cancer later in life.", "Functional consequences of genomic alterations due to Myelodysplastic syndrome (MDS) are poorly understood due to the lack of an animal model.", "Diabetic patients with acute coronary syndrome experience increased short-term and long-term risk for bleeding events.", "Angiotensin converting enzyme inhibitors are associated with increased risk for functional renal insufficiency.", "A high microerythrocyte count raises vulnerability to severe anemia in homozygous alpha (+)- thalassemia trait subjects."], "hard_negative": "Individuals with low serum vitamin D concentrations have increased risk of multiple sclerosis."}
{"query_id": "628", "query_text": "Infection of human T-cell lymphotropic virus type 1 is most frequent in individuals of African origin.", "negative": "UCB T cells maintain high TCR diversity after transplantation.", "negatives": ["UCB T cells maintain high TCR diversity after transplantation.", "Integrating classroom-based collaborative learning with Web-based collaborative learning leads to subpar class performance", "The locus rs647161 is associated with colorectal carcinoma.", "Cells undergoing methionine restriction may activate miRNAs.", "FoxO3a activation in neuronal death is mediated by reactive oxygen species (ROS).", "Incidence rates of cervical cancer have increased due to nationwide screening programs based primarily on cytology to detect uterine cervical cancer.", "Rapamycin decreases the concentration of triacylglycerols in fruit flies.", "NR5A2 is important in development of endometrial tissues.", "Insulin increases risk of severe kidney failure.", "The deregulated and prolonged activation of monocytes has deleterious effects in inflammatory diseases."], "hard_negatives": ["Infection of human T-cell lymphotropic virus type 1 is most frequent in individuals of African origin.", "Human T-lymphotropic virus type-I-associated myelopathy / tropical spastic paraparesis (HAM/TSP) patients produce Immunoglobulin G (IgG) antibodies which cross-react with an immunodominant epitope in Tax.", "T regulatory cells (tTregs) lacking \u03b1v\u03b28 are more adept at suppressing pathogenic T-cell responses during active inflammation.", "Cataract and trachoma are the primary cause of blindness in Southern Sudan.", "Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have a dramatic impact in reducing malaria transmission.", "New drugs for tuberculosis often do not penetrate the necrotic portion of a tuberculosis lesion in high concentrations.", "Mice that lack Interferon-\u03b3 or its receptor exhibit high resistance to experimental autoimmune myocarditis.", "Rapid up-regulation and higher basal expression of interferon-induced genes reduce survival of granule cell neurons that are infected by West Nile virus.", "Reduced responsiveness to interleukin-2 in regulatory T cells is associated with greater resistance to autoimmune diseases such as Type 1 Diabetes.", "Crosstalk between dendritic cells (DCs) and innate lymphoid cells (ILCs) is important in the regulation of intestinal homeostasis."], "hard_negative": "Infection of human T-cell lymphotropic virus type 1 is most frequent in individuals of African origin."}
{"query_id": "636", "query_text": "Inositol lipid 3-phosphatase PTEN converts Ptdlns(3,4)P 2 into phosphatidylinositol 4-phosphate.", "negative": "Combining phosphatidylinositide 3-kinase and MEK 1/2 inhibitors is effective at treating KRAS mutant tumors.", "negatives": ["Combining phosphatidylinositide 3-kinase and MEK 1/2 inhibitors is effective at treating KRAS mutant tumors.", "Incidence of heart failure decreased by 10% in women since 1979.", "The severity of cardiac involvement in amyloidosis can be described by the degree of transmurality of late gadolinium enhancement in MRI.", "Mutations in G-Beta protein GNB2 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.", "Low expression of miR7a exerts a biological function in testis.", "Teaching hospitals do not provide better care than non-teaching hospitals.", "Healthcare delivery efficiency in crowded delivery centers is impaired by improving structural, logistical, and interpersonal elements.", "Infection of human T-cell lymphotropic virus type 1 is most frequent in individuals of African origin.", "Mitochondria are uninvolved in apoptosis.", "High-sensitivity cardiac troponin T (HSCT-T) dosage may not be diagnostic if the onset of symptoms occurs less than 3 hours before acute myocardial injury (AMI)."], "hard_negatives": ["Inositol lipid 3-phosphatase PTEN converts Ptdlns(3,4)P 2 into phosphatidylinositol 4-phosphate.", "Pseudogene PTENP1 regulates the expression of PTEN by functioning as an miRNA decoy.", "Mercaptopurine is anabolized into the inactive methylmercaptopurine by thiopurine methyltrasnferase (TPMT).", "The binding orientation of the ML-SA1 activator at hTRPML2 is different from the binding orientation of the ML-SA1 activator at hTRPML1.", "S-nitrosylated GAPDH physiologically transnitrosylates histone deacetylases.", "PDPN promotes efficient motility along stromal surfaces by activating the C-type lectin receptor to rearrange the actin cytoskeleton in dendritic cells.", "Nanoparticles can be targeted against specific cell types by incorporating aptamers into lipid nanoparticles.", "Ly49Q directs the organization of neutrophil migration to inflammation sites by regulating membrane raft functions.", "Active H. pylori urease has a polymeric structure that compromises two subunits, UreA and UreB.", "GATA-3 is important for hematopoietic stem cell (HSC) function."], "hard_negative": "Inositol lipid 3-phosphatase PTEN converts Ptdlns(3,4)P 2 into phosphatidylinositol 4-phosphate."}
{"query_id": "637", "query_text": "Input from  mental and physical health care professionals is effective at decreasing homelessness.", "negative": "The genomic aberrations found in matasteses are very similar to those found in the primary tumor.", "negatives": ["The genomic aberrations found in matasteses are very similar to those found in the primary tumor.", "Transplanted human glial cells can differentiate within the host animal.", "The minor G allele of FOXO3 is related to more severe symptoms of Crohn's Disease.", "IgA plasma cells that are specific for transglutaminase 2 accumulate in the duodenal mucosa on commencement of a gluten-free diet.", "Only a minority of cells survive development after differentiation into stress-resistant spores.", "Commelina yellow mottle virus' (ComYMV) genome consists of 7489 baise pairs.", "Bone marrow cells contribute to adult macrophage compartments.", "APOE4 expression in iPSC-derived neurons increases AlphaBeta production and tau phosphorylation, delaying GABA neuron degeneration.", "In young and middle-aged adults, current or remote uses of ADHD medications do not increase the risk of serious cardiovascular events.", "Insulin increases risk of severe kidney failure."], "hard_negatives": ["Input from  mental and physical health care professionals is effective at decreasing homelessness.", "The availability of safe places to study is not effective at decreasing homelessness.", "The availability of safe places to study is effective at decreasing homelessness.", "Healthcare delivery efficiency in crowded delivery centers is impaired by improving structural, logistical, and interpersonal elements.", "In young and middle-aged adults, current or remote uses of ADHD medications do not increase the risk of serious cardiovascular events.", "Insomnia can be effectively treated with cognitive behavioral therapy.", "Patients in stable partnerships have a faster progression from HIV to AIDS.", "Bariatric surgery has a positive impact on mental health.", "Non-invasive ventilation use should be decreased if there is inadequate response to conventional treatment.", "Obesity is determined solely by environmental factors."], "hard_negative": "Input from  mental and physical health care professionals is effective at decreasing homelessness."}
{"query_id": "641", "query_text": "Insomnia can be effectively treated with cognitive behavioral therapy.", "negative": "Low expression of miR7a does represses target genes and exerts a biological function in ovaries.", "negatives": ["Low expression of miR7a does represses target genes and exerts a biological function in ovaries.", "5% of perinatal mortality is due to low birth weight.", "TCR/CD3 microdomains are a required to induce the immunologic synapse to activate T cells.", "N348I mutations cause resistance to zidovudine (AZT).", "The minor G allele of FOXO3 is related to more severe symptoms of Crohn's Disease.", "AIRE is expressed in some skin tumors.", "Vitamin D deficiency is unrelated to birth weight.", "Neutrophil extracellular traps (NETs) are released by ANCA-stimulated neutrophils.", "Downregulation and mislocalization of Scribble prevents cell transformation and mammary tumorigenesis.", "Insulin increases risk of severe kidney failure."], "hard_negatives": ["Insomnia can be effectively treated with cognitive behavioral therapy.", "Headaches are not correlated with cognitive impairment.", "In young and middle-aged adults, current or remote uses of ADHD medications do not increase the risk of serious cardiovascular events.", "Febrile seizures reduce the threshold for development of epilepsy.", "Febrile seizures increase the threshold for development of epilepsy.", "Exposure to fine particulate air pollution is relate to anxiety prevalence.", "Hypoglycemia increases the risk of dementia.", "Sildenafil improves erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.", "Hypertension is frequently observed in type 1 diabetes patients.", "Asymptomatic visual impairment screening in elderly populations does not lead to improved vision."], "hard_negative": "Insomnia can be effectively treated with cognitive behavioral therapy."}
{"query_id": "644", "query_text": "Insulin increases risk of severe kidney failure.", "negative": "Increased vessel density along with a reduction in fibrosis decreases the efficacy of chemotherapy treatments.", "negatives": ["Increased vessel density along with a reduction in fibrosis decreases the efficacy of chemotherapy treatments.", "The repair of Cas9-induced double strand breaks in human DNA is error-prone.", "Hyperfibrinogenemia increases rates of femoropopliteal bypass thrombosis.", "Alizarin forms hydrogen bonds with residues involved in PGAM1 substrate binding.", "Occupancy of ribosomes by IncRNAs do not make functional peptides.", "Women with a higher birth weight are more likely to develop breast cancer later in life.", "Inositol lipid 3-phosphatase PTEN converts Ptdlns(3,4)P 2 into phosphatidylinositol 4-phosphate.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have increased risk for dementia.", "Albendazole is used to treat lymphatic filariasis.", "Helminths interfere with immune system control of macrophages activated by IL-4 favor Mycobacterium tuberculosis replication."], "hard_negatives": ["Insulin increases risk of severe kidney failure.", "Hypertension is frequently observed in type 1 diabetes patients.", "Angiotensin converting enzyme inhibitors are associated with increased risk for functional renal insufficiency.", "High levels of copeptin decrease risk of diabetes.", "High dietary calcium intakes are unnecessary for prevention of secondary hyperparathyroidism in subjects with 25(OH)D levels above 75 nmol/liter.", "A deficiency of vitamin B12 increases blood levels of homocysteine.", "The US health care system can save up to $750 million if 7% of patients waiting for kidney transplants participate in the optimized national kidney paired donation program.", "Incidence of heart failure decreased by 10% in women since 1979.", "High cardiopulmonary fitness causes increased mortality rate.", "Obesity decreases life quality."], "hard_negative": "Insulin increases risk of severe kidney failure."}
{"query_id": "649", "query_text": "Integrating classroom-based collaborative learning with Web-based collaborative learning leads to subpar class performance", "negative": "Upregulation of mosGCTL-1 is induced upon infection with West Nile virus.", "negatives": ["Upregulation of mosGCTL-1 is induced upon infection with West Nile virus.", "Inositol lipid 3-phosphatase PTEN converts Ptdlns(3,4)P 2 into phosphatidylinositol 4-phosphate.", "The myocardial lineage develops from cardiac progenitors of mesodermal origin.", "In adult tissue, most T cells are memory T cells.", "Hypothalamic glutamate neurotransmission is crucial to energy balance.", "Radioiodine treatment of non-toxic multinodular goitre reduces thyroid volume.", "Leuko-reduced blood reduces infectious complications in red blood cell transfusion.", "Neutrophil extracellular traps (NETs) are released by ANCA-stimulated neutrophils.", "Incidence of heart failure decreased by 10% in women since 1979.", "PGE 2 promotes intestinal tumor growth by altering the expression of tumor suppressing and DNA repair genes."], "hard_negatives": ["Integrating classroom-based collaborative learning with Web-based collaborative learning leads to subpar class performance", "Healthcare delivery efficiency in crowded delivery centers is impaired by improving structural, logistical, and interpersonal elements.", "Rapid phosphotransfer rates govern fidelity in two component systems", "Input from  mental and physical health care professionals is effective at decreasing homelessness.", "The availability of safe places to study is effective at decreasing homelessness.", "The availability of safe places to study is not effective at decreasing homelessness.", "Participating in six months of physical activity improves cognitive functioning.", "Articles published in open access format are more likely to be cited than traditional journals.", "Non-invasive ventilation use should be decreased if there is inadequate response to conventional treatment.", "Asymptomatic visual impairment screening in elderly populations does not lead to improved vision."], "hard_negative": "Integrating classroom-based collaborative learning with Web-based collaborative learning leads to subpar class performance"}
{"query_id": "659", "query_text": "Ivermectin is used to treat lymphatic filariasis.", "negative": "Ly6C hi monocytes have a lower inflammatory capacity compared to their Ly6C lo counterparts.", "negatives": ["Ly6C hi monocytes have a lower inflammatory capacity compared to their Ly6C lo counterparts.", "New drugs for tuberculosis often do not penetrate the necrotic portion of a tuberculosis lesion in high concentrations.", "S-nitrosylated GAPDH physiologically transnitrosylates histone deacetylases.", "Occupancy of ribosomes by IncRNAs mirror 5 0-UTRs", "Ivermectin is used to treat onchocerciasis.", "Autologous transplantation of mesenchymal stem cells has lower rates of rejection than induction therapy with anti-interleukin-2 receptor antibodies.", "Mice defective for deoxyribonucleic acid (DNA) polymerase I (polI) reveal increased sensitivity to ionizing radiation (IR).", "Chronic aerobic exercise alters endothelial function, improving vasodilating mechanisms mediated by NO.", "Golli-deficient T-cells prefer to differentiate into an anergic phenotype in the adaptive immune response when there are increased levels of Ca2+ in the cytosol.", "Reduced responsiveness to interleukin-2 in regulatory T cells is associated with greater resistance to autoimmune diseases such as Type 1 Diabetes."], "hard_negatives": ["Ivermectin is used to treat lymphatic filariasis.", "Albendazole is used to treat lymphatic filariasis.", "Ivermectin is used to treat onchocerciasis.", "Increased vessel density along with a reduction in fibrosis decreases the efficacy of chemotherapy treatments.", "Tetraspanin-3 is a causative factor in the development of acute myelogenous leukemia", "Crosstalk between dendritic cells (DCs) and innate lymphoid cells (ILCs) is important in the regulation of intestinal homeostasis.", "Metastatic colorectal cancer treated with a single agent fluoropyrimidines resulted in reduced efficacy and lower quality of life when compared with oxaliplatin-based chemotherapy in elderly patients.", "Varenicline monotherapy is more effective after 12 weeks of treatment compared to combination nicotine replacement therapies with varenicline or bupropion.", "The treatment of cancer patients with co-IR blockade does not cause any adverse autoimmune events.", "AMP-activated protein kinase (AMPK) activation increases inflammation-related fibrosis in the lungs."], "hard_negative": "Ivermectin is used to treat lymphatic filariasis."}
{"query_id": "660", "query_text": "Ivermectin is used to treat onchocerciasis.", "negative": "Commelina yellow mottle virus' (ComYMV) genome consists of 7489 baise pairs.", "negatives": ["Commelina yellow mottle virus' (ComYMV) genome consists of 7489 baise pairs.", "CR is associated with higher methylation age.", "Bariatric surgery has a positive impact on mental health.", "Upregulation of mosGCTL-1 is induced upon infection with West Nile virus.", "APOE4 expression in iPSC-derived neurons increases AlphaBeta production and tau phosphorylation, delaying GABA neuron degeneration.", "UCB T cells maintain high TCR diversity after transplantation.", "The one-child policy has been successful in lowering population growth.", "High-sensitivity cardiac troponin T (HSCT-T) dosage may not be diagnostic if the onset of symptoms occurs less than 3 hours before acute myocardial injury (AMI).", "Diabetic patients with acute coronary syndrome experience increased short-term and long-term risk for bleeding events.", "ADAR1 binds to Dicer to cleave pre-miRNA."], "hard_negatives": ["Ivermectin is used to treat onchocerciasis.", "Ivermectin is used to treat lymphatic filariasis.", "Albendazole is used to treat lymphatic filariasis.", "Sildenafil improves erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.", "Dexamethasone decreases risk of postoperative bleeding.", "Varenicline monotherapy is more effective after 12 weeks of treatment compared to combination nicotine replacement therapies with varenicline or bupropion.", "The treatment of cancer patients with co-IR blockade does not cause any adverse autoimmune events.", "Stroke patients with prior use of direct oral anticoagulants have a lower risk of in-hospital mortality than stroke patients with prior use of warfarin.", "Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have a dramatic impact in reducing malaria transmission.", "Aspirin inhibits the production of PGE2."], "hard_negative": "Ivermectin is used to treat onchocerciasis."}
{"query_id": "674", "query_text": "LDL cholesterol has no involvement in the development of cardiovascular disease.", "negative": "Macropinocytosis contributes to a cell's supply of amino acids via the intracellular uptake of protein.", "negatives": ["Macropinocytosis contributes to a cell's supply of amino acids via the intracellular uptake of protein.", "Ly6C hi monocytes have a lower inflammatory capacity than Ly6C lo monocytes.", "1/2000 in UK have abnormal PrP positivity.", "The binding orientation of the ML-SA1 activator at hTRPML2 is different from the binding orientation of the ML-SA1 activator at hTRPML1.", "Metastatic colorectal cancer treated with a single agent fluoropyrimidines resulted in reduced efficacy and lower quality of life when compared with oxaliplatin-based chemotherapy in elderly patients.", "Fz/PCP-dependent Pk localizes to the anterior membrane of notochord cells during zebrafish neuralation.", "PDPN promotes efficient motility along stromal surfaces by activating the C-type lectin receptor to rearrange the actin cytoskeleton in dendritic cells.", "Human T-lymphotropic virus type-I-associated myelopathy / tropical spastic paraparesis (HAM/TSP) patients produce Immunoglobulin G (IgG) antibodies which cross-react with an immunodominant epitope in Tax.", "HNF4A mutations can cause diabetes in mutant carriers by the age of 14 years", "Cellular aging closely links to an older appearance."], "hard_negatives": ["LDL cholesterol has no involvement in the development of cardiovascular disease.", "Statins decrease blood cholesterol.", "Statins increase blood cholesterol.", "A deficiency of vitamin B12 increases blood levels of homocysteine.", "High dietary calcium intakes are unnecessary for prevention of secondary hyperparathyroidism in subjects with 25(OH)D levels above 75 nmol/liter.", "Vitamin D deficiency is unrelated to birth weight.", "Sildenafil improves erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.", "High levels of CRP reduces the risk of exacerbations in chronic obstructive pulmonary disease (COPD).", "Dexamethasone decreases risk of postoperative bleeding.", "In young and middle-aged adults, current or remote uses of ADHD medications do not increase the risk of serious cardiovascular events."], "hard_negative": "LDL cholesterol has no involvement in the development of cardiovascular disease."}
{"query_id": "684", "query_text": "Lack of clpC does not affect sporulation efficiency in Bacillus subtilis cells.", "negative": "MicroRNA is involved in the regulation of Neural Stem Cell (NSC) differentiation and proliferation dynamic homeostasis", "negatives": ["MicroRNA is involved in the regulation of Neural Stem Cell (NSC) differentiation and proliferation dynamic homeostasis", "Alizarin forms hydrogen bonds with residues involved in PGAM1 substrate binding.", "Metastatic colorectal cancer treated with a single agent fluoropyrimidines resulted in reduced efficacy and lower quality of life when compared with oxaliplatin-based chemotherapy in elderly patients.", "Many proteins in human cells can be post-translationally modified at lysine residues via acetylation.", "De novo assembly of sequence data has more specific contigs than unassembled sequence data.", "Arterioles have a larger lumen diameter than venules.", "Cold exposure reduces BAT recruitment.", "The arm density of TatAd complexes is due to structural rearrangements within Class1 TatAd complexes such as the 'charge zipper mechanism'.", "New drugs for tuberculosis often do not penetrate the necrotic portion of a tuberculosis lesion in high concentrations.", "CR is associated with higher methylation age."], "hard_negatives": ["Lack of clpC does not affect sporulation efficiency in Bacillus subtilis cells.", "Cells lacking clpC have a defect in sporulation efficiency in Bacillus subtilis.", "Ly6C hi monocytes have a lower inflammatory capacity compared to their Ly6C lo counterparts.", "Ly6C hi monocytes have a lower inflammatory capacity than Ly6C lo monocytes.", "Ethanol stress decreases the expression of IBP in bacteria.", "Increased vessel density along with a reduction in fibrosis decreases the efficacy of chemotherapy treatments.", "mTORC2 regulates intracellular cysteine levels through xCT inhibition.", "aPKCz causes tumour enhancement by affecting glutamine metabolism.", "Crossover hot spots are not found within gene promoters in Saccharomyces cerevisiae.", "Proteins synthesized at the growth cone are ubiquitinated at a higher rate than proteins from the cell body."], "hard_negative": "Lack of clpC does not affect sporulation efficiency in Bacillus subtilis cells."}
{"query_id": "690", "query_text": "Less than 10% of the gabonese children with Schimmelpenning-Feuerstein-Mims syndrome (SFM) had a plasma lactate of more than 5mmol/L.", "negative": "CX3CR1 on the Th2 cells promotes airway inflammation.", "negatives": ["CX3CR1 on the Th2 cells promotes airway inflammation.", "The DdrB protein from Deinococcus radiodurans is an alternative SSB.", "Tetraspanin-3 is a causative factor in the development of acute myelogenous leukemia", "Deletion of \u03b1v\u03b28 does not result in a spontaneous inflammatory phenotype.", "Combining phosphatidylinositide 3-kinase and MEK 1/2 inhibitors is effective at treating KRAS mutant tumors.", "Primary cervical cancer screening with HPV detection has higher longitudinal sensitivity than conventional cytology to detect cervical intraepithelial neoplasia grade 2.", "The risk of breast cancer among parous women increases with placental weight of pregnancies, and this association is strongest for premenopausal breast cancer.", "Activator-inhibitor pairs are provided dorsally by Admpchordin.", "Low expression of miR7a does represses target genes and exerts a biological function in ovaries.", "The severity of cardiac involvement in amyloidosis can be described by the degree of transmurality of late gadolinium enhancement in MRI."], "hard_negatives": ["Less than 10% of the gabonese children with Schimmelpenning-Feuerstein-Mims syndrome (SFM) had a plasma lactate of more than 5mmol/L.", "High dietary calcium intakes are unnecessary for prevention of secondary hyperparathyroidism in subjects with 25(OH)D levels above 75 nmol/liter.", "Human T-lymphotropic virus type-I-associated myelopathy / tropical spastic paraparesis (HAM/TSP) patients produce Immunoglobulin G (IgG) antibodies which cross-react with an immunodominant epitope in Tax.", "Mutant mice lacking SVCT2 have greatly increased ascorbic acid levels in both brain and adrenals.", "Functional consequences of genomic alterations due to Myelodysplastic syndrome (MDS) are poorly understood due to the lack of an animal model.", "Mice that lack Interferon-\u03b3 or its receptor exhibit high resistance to experimental autoimmune myocarditis.", "Infection of human T-cell lymphotropic virus type 1 is most frequent in individuals of African origin.", "Cataract and trachoma are the primary cause of blindness in Southern Sudan.", "Taxation of sugar-sweetened beverages had no effect on the incidence rate of type II diabetes in India.", "HNF4A mutations can cause diabetes in mutant carriers by the age of 14 years"], "hard_negative": "Less than 10% of the gabonese children with Schimmelpenning-Feuerstein-Mims syndrome (SFM) had a plasma lactate of more than 5mmol/L."}
{"query_id": "691", "query_text": "Leukemia associated Rho guanine nucleotide-exchange factor represses RhoA in response to SRC activation.", "negative": "Ribosomopathies have a low degree of cell and tissue specific pathology.", "negatives": ["Ribosomopathies have a low degree of cell and tissue specific pathology.", "Rapid up-regulation and higher basal expression of interferon-induced genes reduce survival of granule cell neurons that are infected by West Nile virus.", "The tip of the inner tube of the toxic type VI secretion system (T6SS) antibacterial effector in Escherichia coli (E. coli) carries toxic effector proteins.", "Ethanol stress decreases the expression of IBP in bacteria.", "The combination of H3K4me3 and H3K79me2 is found in quiescent hair follicle stem cells.", "Homozygous deletion of murine Sbds gene from osterix-expressing mesenchymal stem and progenitor cells (MPCs) prevents oxidative stress.", "APOE4 expression in iPSC-derived neurons increases AlphaBeta production and tau phosphorylation, delaying GABA neuron degeneration.", "Proteins synthesized at the growth cone are ubiquitinated at a higher rate than proteins from the cell body.", "Reduced responsiveness to interleukin-2 in regulatory T cells is associated with greater resistance to autoimmune diseases such as Type 1 Diabetes.", "The genomic aberrations found in matasteses are very similar to those found in the primary tumor."], "hard_negatives": ["Leukemia associated Rho guanine nucleotide-exchange factor represses RhoA in response to SRC activation.", "FoxO3a activation in neuronal death is mediated by reactive oxygen species (ROS).", "ITAM phosphorylation prevents the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).", "Tetraspanin-3 is a causative factor in the development of acute myelogenous leukemia", "AMP-activated protein kinase (AMPK) activation increases inflammation-related fibrosis in the lungs.", "Low expression of miR7a does represses target genes and exerts a biological function in ovaries.", "Mice without IFN-\u03b3 or its receptor are resistant to EAM induced with \u03b1-MyHC/CFA.", "The treatment of cancer patients with co-IR blockade precipitates adverse autoimmune events.", "PPAR-RXRs can be activated by PPAR ligands.", "Low expression of miR7a exerts a biological function in testis."], "hard_negative": "Leukemia associated Rho guanine nucleotide-exchange factor represses RhoA in response to SRC activation."}
{"query_id": "692", "query_text": "Leuko-increased blood increases infectious complications in red blood cell transfusion.", "negative": "Flexible molecules experience greater steric hindrance in the tumor microenviroment than rigid molecules.", "negatives": ["Flexible molecules experience greater steric hindrance in the tumor microenviroment than rigid molecules.", "Occupancy of ribosomes by IncRNAs mirror 5 0-UTRs", "Neutrophil extracellular traps (NETs) are released by ANCA-stimulated neutrophils.", "Activator-inhibitor pairs are provided dorsally by Admpchordin.", "Leuko-reduced blood reduces infectious complications in red blood cell transfusion.", "Only a minority of cells survive development after differentiation into stress-resistant spores.", "S-nitrosylated GAPDH physiologically transnitrosylates histone deacetylases.", "Birth-weight is positively associated with breast cancer.", "FoxO3a activation in neuronal death is mediated by reactive oxygen species (ROS).", "Taking 400mg of \u03b1-tocopheryl acetate helps to prevent prostate cancer."], "hard_negatives": ["Leuko-increased blood increases infectious complications in red blood cell transfusion.", "Leuko-reduced blood reduces infectious complications in red blood cell transfusion.", "Diabetic patients with acute coronary syndrome experience increased short-term and long-term risk for bleeding events.", "Statins increase blood cholesterol.", "Statins decrease blood cholesterol.", "Increased vessel density along with a reduction in fibrosis decreases the efficacy of chemotherapy treatments.", "Hematopoietic Stem Cell purification reaches purity rate of up to 50%.", "High levels of CRP reduces the risk of exacerbations in chronic obstructive pulmonary disease (COPD).", "Mice that lack Interferon-\u03b3 or its receptor exhibit high resistance to experimental autoimmune myocarditis.", "Dexamethasone decreases risk of postoperative bleeding."], "hard_negative": "Leuko-increased blood increases infectious complications in red blood cell transfusion."}
{"query_id": "693", "query_text": "Leuko-reduced blood reduces infectious complications in red blood cell transfusion.", "negative": "Venules have a thinner or absent smooth layer compared to arterioles.", "negatives": ["Venules have a thinner or absent smooth layer compared to arterioles.", "Auditory entrainment is strengthened when people see congruent visual and auditory information.", "Articles published in open access format are more likely to be cited than traditional journals.", "Epidemiological disease burden from noncommunicable diseases is more prevalent in low economic settings.", "Incidence rates of cervical cancer have increased due to nationwide screening programs based primarily on cytology to detect uterine cervical cancer.", "Metastatic colorectal cancer treated with a single agent fluoropyrimidines resulted in reduced efficacy and lower quality of life when compared with oxaliplatin-based chemotherapy in elderly patients.", "Polymeal nutrition reduces cardiovascular mortality.", "Activator-inhibitor pairs are provided dorsally by Admpchordin.", "Rapid up-regulation and higher basal expression of interferon-induced genes increase survival of granule cell neurons that are infected by West Nile virus.", "Lupus-prone mice infected with curliproducing bacteria have higher autoantibody titers compared to controls."], "hard_negatives": ["Leuko-reduced blood reduces infectious complications in red blood cell transfusion.", "Leuko-increased blood increases infectious complications in red blood cell transfusion.", "Hematopoietic Stem Cell purification reaches purity rate of up to 50%.", "Diabetic patients with acute coronary syndrome experience increased short-term and long-term risk for bleeding events.", "Statins decrease blood cholesterol.", "Statins increase blood cholesterol.", "High levels of CRP reduces the risk of exacerbations in chronic obstructive pulmonary disease (COPD).", "Dexamethasone decreases risk of postoperative bleeding.", "Mice that lack Interferon-\u03b3 or its receptor exhibit high resistance to experimental autoimmune myocarditis.", "CRP is not predictive of postoperative mortality following Coronary Artery Bypass Graft (CABG) surgery."], "hard_negative": "Leuko-reduced blood reduces infectious complications in red blood cell transfusion."}
{"query_id": "700", "query_text": "Localization of PIN1 in the Arabidopsis embryo does not require VPS9a", "negative": "Less than 10% of the gabonese children with Schimmelpenning-Feuerstein-Mims syndrome (SFM) had a plasma lactate of more than 5mmol/L.", "negatives": ["Less than 10% of the gabonese children with Schimmelpenning-Feuerstein-Mims syndrome (SFM) had a plasma lactate of more than 5mmol/L.", "Macrolides have no protective effect against myocardial infarction.", "Bone marrow cells contribute to adult macrophage compartments.", "Mutations in G-Beta protein GNB2 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.", "The genomic aberrations found in matasteses are very similar to those found in the primary tumor.", "ADAR1 binds to Dicer to cleave pre-miRNA.", "During the primary early antibody response activated B cells migrate toward the inner-and outer paracortical areas where oxysterol accumulation is generated by stromal cells.", "AMP-activated protein kinase (AMPK) activation increases inflammation-related fibrosis in the lungs.", "Women with a higher birth weight are more likely to develop breast cancer later in life.", "Hypothalamic glutamate neurotransmission is crucial to energy balance."], "hard_negatives": ["Localization of PIN1 in the Arabidopsis embryo does not require VPS9a", "Localization of PIN1 in the roots of Arabidopsis does not require VPS9a", "Low expression of miR7a does represses target genes and exerts a biological function in ovaries.", "Low expression of miR7a exerts a biological function in testis.", "IFIT1 restricts viral replication by sequestrating mis-capped viral RNAs.", "Ubiquitin ligase UBC13 generates a K63-linked polyubiquitin moiety at PCNA K164.", "Alizarin forms hydrogen bonds with residues involved in PGAM1 substrate binding.", "The repair of Cas9-induced double strand breaks in human DNA is error-prone.", "Pseudogene PTENP1 regulates the expression of PTEN by functioning as an miRNA decoy.", "Occupancy of ribosomes by IncRNAs mirror 5 0-UTRs"], "hard_negative": "Localization of PIN1 in the Arabidopsis embryo does not require VPS9a"}
{"query_id": "702", "query_text": "Localization of PIN1 in the roots of Arabidopsis does not require VPS9a", "negative": "Pretreatment with the Arp2/3 inhibitor CK-666 affects lamelliopodia formation.", "negatives": ["Pretreatment with the Arp2/3 inhibitor CK-666 affects lamelliopodia formation.", "Modifying the epigenome in the brain affects the normal human aging process by affecting certain genes related to neurogenesis.", "Leuko-increased blood increases infectious complications in red blood cell transfusion.", "N-terminal cleavage increases success identifying transcription start sites.", "Chenodeosycholic acid treatment increases whole-body energy expenditure.", "The single flash-evoked ERG b-wave is generated by activity of ON-bipolar cells.", "Transferred UCB T cells acquire a memory-like phenotype in recipients.", "Many proteins in human cells can be post-translationally modified at lysine residues via acetylation.", "Healthcare delivery efficiency in crowded delivery centers is impaired by improving structural, logistical, and interpersonal elements.", "UCB T cells reduce TCR diversity after transplantation."], "hard_negatives": ["Localization of PIN1 in the roots of Arabidopsis does not require VPS9a", "Localization of PIN1 in the Arabidopsis embryo does not require VPS9a", "Low expression of miR7a does represses target genes and exerts a biological function in ovaries.", "Low expression of miR7a exerts a biological function in testis.", "Ubiquitin ligase UBC13 generates a K63-linked polyubiquitin moiety at PCNA K164.", "Alizarin forms hydrogen bonds with residues involved in PGAM1 substrate binding.", "The PPR MDA5 has two N-terminal CARD domains.", "Pseudogene PTENP1 regulates the expression of PTEN by functioning as an miRNA decoy.", "N348I mutations cause resistance to zidovudine (AZT).", "Low nucleosome occupancy correlates with low methylation levels across species."], "hard_negative": "Localization of PIN1 in the roots of Arabidopsis does not require VPS9a"}
{"query_id": "715", "query_text": "Low expression of miR7a does represses target genes and exerts a biological function in ovaries.", "negative": "Diabetic patients with acute coronary syndrome experience increased short-term and long-term risk for bleeding events.", "negatives": ["Diabetic patients with acute coronary syndrome experience increased short-term and long-term risk for bleeding events.", "New drugs for tuberculosis often do not penetrate the necrotic portion of a tuberculosis lesion in high concentrations.", "Chenodeosycholic acid treatment reduces whole-body energy expenditure.", "Recurrent mutations occur frequently within CTCF anchor sites adjacent to oncogenes.", "UCB T cells maintain high TCR diversity after transplantation.", "Dexamethasone decreases risk of postoperative bleeding.", "Primary pro-inflammatory cytokines induce secondary pro- and anti-inflammatory mediators.", "The sliding activity of kinesin-8 protein Kip3 promotes bipolar spindle assembly.", "Assembly of invadopodia is triggered by focal generation of phosphatidylinositol-3,4-biphosphate and the activation of the nonreceptor tyrosine kinase Src.", "In transgenic mice harboring green florescent protein under the control of the Sox2 promoter, less than ten percent of the cells with green florescent colocalize with cell proliferation markers."], "hard_negatives": ["Low expression of miR7a does represses target genes and exerts a biological function in ovaries.", "Low expression of miR7a exerts a biological function in testis.", "ADAR1 binds to Dicer to cleave pre-miRNA.", "Cells undergoing methionine restriction may activate miRNAs.", "TNFAIP3 is a tumor suppressor in glioblastoma.", "ALDH1 expression is associated with better breast cancer outcomes.", "Pseudogene PTENP1 regulates the expression of PTEN by functioning as an miRNA decoy.", "ALDH1 expression is associated with poorer prognosis in breast cancer.", "Localization of PIN1 in the Arabidopsis embryo does not require VPS9a", "The locus rs647161 is associated with colorectal carcinoma."], "hard_negative": "Low expression of miR7a does represses target genes and exerts a biological function in ovaries."}
{"query_id": "716", "query_text": "Low expression of miR7a exerts a biological function in testis.", "negative": "Reduced responsiveness to interleukin-2 in regulatory T cells is associated with greater resistance to autoimmune diseases such as Type 1 Diabetes.", "negatives": ["Reduced responsiveness to interleukin-2 in regulatory T cells is associated with greater resistance to autoimmune diseases such as Type 1 Diabetes.", "Functional consequences of genomic alterations due to Myelodysplastic syndrome (MDS) are poorly understood due to the lack of an animal model.", "CCL19 is absent within dLNs.", "Statins increase blood cholesterol.", "Tumor necrosis factor alpha (TNF-\u03b1) and interleukin-1 (IL-1) are pro-inflammatory cytokines that inhibit IL-6 and IL-10.", "CR is associated with higher methylation age.", "Recurrent mutations occur frequently within CTCF anchor sites adjacent to oncogenes.", "Auditory entrainment is strengthened when people see congruent visual and auditory information.", "In domesticated populations of Saccharomyces cerevisiae, whole chromosome aneuploidy is very uncommon.", "Reduced responsiveness to interleukin-2 in regulatory T cells is associated with greater resistance to autoimmune diseases such as Type 1 Diabetes."], "hard_negatives": ["Low expression of miR7a exerts a biological function in testis.", "Low expression of miR7a does represses target genes and exerts a biological function in ovaries.", "TNFAIP3 is a tumor suppressor in glioblastoma.", "ADAR1 binds to Dicer to cleave pre-miRNA.", "The locus rs647161 is associated with colorectal carcinoma.", "ITAM phosphorylation prevents the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).", "ALDH1 expression is associated with better breast cancer outcomes.", "Pseudogene PTENP1 regulates the expression of PTEN by functioning as an miRNA decoy.", "ALDH1 expression is associated with poorer prognosis in breast cancer.", "Cells undergoing methionine restriction may activate miRNAs."], "hard_negative": "Low expression of miR7a exerts a biological function in testis."}
{"query_id": "718", "query_text": "Low nucleosome occupancy correlates with low methylation levels across species.", "negative": "The PPR MDA5 has two N-terminal CARD domains.", "negatives": ["The PPR MDA5 has two N-terminal CARD domains.", "Cells lacking clpC have a defect in sporulation efficiency in Bacillus subtilis.", "aPKCz causes tumour enhancement by affecting glutamine metabolism.", "Glycolysis is one of the primary glycometabolic pathways in cells.", "The risk of breast cancer among parous women increases with placental weight of pregnancies, and this association is strongest for premenopausal breast cancer.", "Errors in peripheral IV drug administration are most common during bolus administration and multiple-step medicine preparations.", "Primary pro-inflammatory cytokines induce secondary pro- and anti-inflammatory mediators.", "Ly49Q directs the organization of neutrophil migration to inflammation sites by regulating membrane raft functions.", "The composition of myosin-II isoform switches from the polarizable B isoform to the more homogenous A isoform during hematopoietic differentiation.", "Errors in peripheral IV drug administration are most common during bolus administration and multiple-step medicine preparations."], "hard_negatives": ["Low nucleosome occupancy correlates with low methylation levels across species.", "CR is associated with higher methylation age.", "Histone demethylase recruitment and a transient decrease in histone methylation is necessary for ligand-dependent induction of transcription by nuclear receptors.", "Occupancy of ribosomes by IncRNAs mirror 5 0-UTRs", "Gene expression does not vary appreciably across genetically identical cells.", "N-terminal cleavage reduces success identifying transcription start sites.", "A deficiency of vitamin B12 increases blood levels of homocysteine.", "Free histones are degraded by a Rad53-dependent mechanism once DNA has been replicated.", "The ureABIEFGH gene cluster is induced by nickel (II) ion.", "N-terminal cleavage increases success identifying transcription start sites."], "hard_negative": "Low nucleosome occupancy correlates with low methylation levels across species."}
{"query_id": "721", "query_text": "Lupus-prone mice infected with curliproducing bacteria have higher autoantibody titers compared to controls.", "negative": "Tirasemtiv has no effect on fast-twitch muscle.", "negatives": ["Tirasemtiv has no effect on fast-twitch muscle.", "Epigenetic modulating agents (EMAs) modulate antitumor immune response in a cancer model system.", "Rapamycin decreases the concentration of triacylglycerols in fruit flies.", "Rapid up-regulation and higher basal expression of interferon-induced genes reduce survival of granule cell neurons that are infected by West Nile virus.", "PDPN promotes efficient motility along stromal surfaces by activating the C-type lectin receptor to rearrange the actin cytoskeleton in dendritic cells.", "Mercaptopurine is anabolized into the inactive methylmercaptopurine by thiopurine methyltrasnferase (TPMT).", "Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have a dramatic impact in reducing malaria transmission.", "Sildenafil improves erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.", "Homozygous deletion of murine Sbds gene from osterix-expressing mesenchymal stem and progenitor cells (MPCs) prevents oxidative stress.", "1/2000 in UK have abnormal PrP positivity."], "hard_negatives": ["Lupus-prone mice infected with curliproducing bacteria have higher autoantibody titers compared to controls.", "Mutant mice lacking SVCT2 have greatly increased ascorbic acid levels in both brain and adrenals.", "In mice, P. chabaudi parasites are able to proliferate faster early in infection when inoculated at lower numbers than when inoculated at high numbers.", "Basophils counteract disease development in patients with systemic lupus erythematosus (SLE).", "Mice that lack Interferon-\u03b3 or its receptor exhibit high resistance to experimental autoimmune myocarditis.", "Rapid up-regulation and higher basal expression of interferon-induced genes reduce survival of granule cell neurons that are infected by West Nile virus.", "Deletion of \u03b1v\u03b28 does not result in a spontaneous inflammatory phenotype.", "Rapid up-regulation and higher basal expression of interferon-induced genes increase survival of granule cell neurons that are infected by West Nile virus.", "Helminths interfere with immune system control of macrophages activated by IL-4 favor Mycobacterium tuberculosis replication.", "A high microerythrocyte count raises vulnerability to severe anemia in homozygous alpha (+)- thalassemia trait subjects."], "hard_negative": "Lupus-prone mice infected with curliproducing bacteria have higher autoantibody titers compared to controls."}
{"query_id": "723", "query_text": "Ly49Q directs the organization of neutrophil migration to inflammation sites by regulating membrane raft functions.", "negative": "Epigenetic modulating agents (EMAs) modulate antitumor immune response in a cancer model system.", "negatives": ["Epigenetic modulating agents (EMAs) modulate antitumor immune response in a cancer model system.", "MicroRNA is involved in the regulation of Neural Stem Cell (NSC) differentiation and proliferation dynamic homeostasis", "Tetraspanin-3 is a causative factor in the development of acute myelogenous leukemia", "PD-1 triggering on monocytes reduces IL-10 production by monocytes.", "Cell autonomous sex determination in somatic cells occurs in Passeriformes.", "Mitochondria are uninvolved in apoptosis.", "Hyperfibrinogenemia increases rates of femoropopliteal bypass thrombosis.", "Non-invasive ventilation use should be decreased if there is inadequate response to conventional treatment.", "Varenicline monotherapy is more effective after 12 weeks of treatment compared to combination nicotine replacement therapies with varenicline or bupropion.", "The PPR MDA5 has two N-terminal CARD domains."], "hard_negatives": ["Ly49Q directs the organization of neutrophil migration to inflammation sites by regulating membrane raft functions.", "PDPN promotes efficient motility along stromal surfaces by activating the C-type lectin receptor to rearrange the actin cytoskeleton in dendritic cells.", "AMP-activated protein kinase (AMPK) activation increases inflammation-related fibrosis in the lungs.", "Blocking the interaction between TDP-43 and respiratory complex I proteins ND3 and ND6 leads to increased TDP-43-induced neuronal loss.", "Crosstalk between dendritic cells (DCs) and innate lymphoid cells (ILCs) is important in the regulation of intestinal homeostasis.", "Pleiotropic coupling of GLP-1R to intracellular effectors promotes distinct profiles of cellular signaling.", "ITAM phosphorylation prevents the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).", "CX3CR1 on the Th2 cells promotes airway inflammation.", "MicroRNA is involved in the regulation of Neural Stem Cell (NSC) differentiation and proliferation dynamic homeostasis", "CX3CR1 on the Th2 cells suppresses airway inflammation."], "hard_negative": "Ly49Q directs the organization of neutrophil migration to inflammation sites by regulating membrane raft functions."}
{"query_id": "727", "query_text": "Ly6C hi monocytes have a lower inflammatory capacity compared to their Ly6C lo counterparts.", "negative": "Downregulation and mislocalization of Scribble prevents cell transformation and mammary tumorigenesis.", "negatives": ["Downregulation and mislocalization of Scribble prevents cell transformation and mammary tumorigenesis.", "NF2 (Merlin) prevents phosphorylation and subsequent cytoplasmic sequestration of YAP in Drosophila.", "The loss of the TET protein functions may have dire biological consequences, such as myeloid cancers.", "1,000 genomes project enables mapping of genetic sequence variation consisting of rare variants with larger penetrance effects than common variants.", "CHEK2 is not associated with breast cancer.", "The treatment of cancer patients with co-IR blockade does not cause any adverse autoimmune events.", "Autologous transplantation of mesenchymal stem cells causes a higher rate of opportunistic infections than induction therapy with anti-interleukin-2 receptor antibodies.", "The benefits of colchicine were achieved with effective widespread use of secondary prevention strategies such as high-dose statins.", "Free histones are degraded by a Rad53-dependent mechanism once DNA has been replicated.", "Blocking the interaction between TDP-43 and respiratory complex I proteins ND3 and ND6 leads to increased TDP-43-induced neuronal loss."], "hard_negatives": ["Ly6C hi monocytes have a lower inflammatory capacity compared to their Ly6C lo counterparts.", "Ly6C hi monocytes have a lower inflammatory capacity than Ly6C lo monocytes.", "Crosstalk between dendritic cells (DCs) and innate lymphoid cells (ILCs) is important in the regulation of intestinal homeostasis.", "CX3CR1 on the Th2 cells promotes airway inflammation.", "The deregulated and prolonged activation of monocytes has deleterious effects in inflammatory diseases.", "CX3CR1 on the Th2 cells suppresses airway inflammation.", "Ly49Q directs the organization of neutrophil migration to inflammation sites by regulating membrane raft functions.", "CR is associated with higher methylation age.", "Leukemia associated Rho guanine nucleotide-exchange factor represses RhoA in response to SRC activation.", "Bone marrow cells contribute to adult macrophage compartments."], "hard_negative": "Ly6C hi monocytes have a lower inflammatory capacity compared to their Ly6C lo counterparts."}
{"query_id": "728", "query_text": "Ly6C hi monocytes have a lower inflammatory capacity than Ly6C lo monocytes.", "negative": "Exposure to fine particulate air pollution is relate to anxiety prevalence.", "negatives": ["Exposure to fine particulate air pollution is relate to anxiety prevalence.", "Incidence rates of cervical cancer have decreased.", "The repair of Cas9-induced double strand breaks in human DNA is error-prone.", "Reduced responsiveness to interleukin-2 in regulatory T cells is associated with greater resistance to autoimmune diseases such as Type 1 Diabetes.", "Immune responses result in the development of inflammatory Th17 cells and anti-inflammatory iTregs.", "Inositol lipid 3-phosphatase PTEN converts Ptdlns(3,4)P 2 into phosphatidylinositol 4-phosphate.", "Blocking the interaction between TDP-43 and respiratory complex I proteins ND3 and ND6 leads to increased TDP-43-induced neuronal loss.", "Albendazole is used to treat lymphatic filariasis.", "Articles published in open access format are more likely to be cited than traditional journals.", "Participating in six months of physical activity improves cognitive functioning."], "hard_negatives": ["Ly6C hi monocytes have a lower inflammatory capacity than Ly6C lo monocytes.", "Ly6C hi monocytes have a lower inflammatory capacity compared to their Ly6C lo counterparts.", "CX3CR1 on the Th2 cells promotes airway inflammation.", "The deregulated and prolonged activation of monocytes has deleterious effects in inflammatory diseases.", "Crosstalk between dendritic cells (DCs) and innate lymphoid cells (ILCs) is important in the regulation of intestinal homeostasis.", "CX3CR1 on the Th2 cells suppresses airway inflammation.", "Bone marrow cells contribute to adult macrophage compartments.", "Ly49Q directs the organization of neutrophil migration to inflammation sites by regulating membrane raft functions.", "CR is associated with higher methylation age.", "Leukemia associated Rho guanine nucleotide-exchange factor represses RhoA in response to SRC activation."], "hard_negative": "Ly6C hi monocytes have a lower inflammatory capacity than Ly6C lo monocytes."}
{"query_id": "729", "query_text": "Lymphadenopathy is observed in knockin mouse lacking the SHP-2 MAPK pathway.", "negative": "The extracellular domain of TMEM27 is cleaved in human beta cells.", "negatives": ["The extracellular domain of TMEM27 is cleaved in human beta cells.", "CHEK2 is not associated with breast cancer.", "Obesity is determined solely by environmental factors.", "The availability of safe places to study is effective at decreasing homelessness.", "Functional consequences of genomic alterations due to Myelodysplastic syndrome (MDS) are poorly understood due to the lack of an animal model.", "Integrating classroom-based collaborative learning with Web-based collaborative learning leads to subpar class performance", "There is an inverse relationship between hip fractures and statin use.", "IgA plasma cells that are specific for transglutaminase 2 accumulate in the duodenal mucosa on commencement of a gluten-free diet.", "Integrating classroom-based collaborative learning with Web-based collaborative learning leads to subpar class performance", "Insomnia can be effectively treated with cognitive behavioral therapy."], "hard_negatives": ["Lymphadenopathy is observed in knockin mouse lacking the SHP-2 MAPK pathway.", "Reduced responsiveness to interleukin-2 in regulatory T cells is associated with greater resistance to autoimmune diseases such as Type 1 Diabetes.", "Crosstalk between dendritic cells (DCs) and innate lymphoid cells (ILCs) is important in the regulation of intestinal homeostasis.", "In mouse models, the loss of CSF1R facilitates MOZ-TIF2-induced leuekmogenesis.", "The extracellular domain of TMEM27 is cleaved in human beta cells.", "FoxO3a activation in neuronal death is mediated by reactive oxygen species (ROS).", "Mice that lack Interferon-\u03b3 or its receptor exhibit high resistance to experimental autoimmune myocarditis.", "CX3CR1 on the Th2 cells suppresses airway inflammation.", "CX3CR1 on the Th2 cells impairs T cell survival", "Arginine 90 in p150n is important for interaction with EB1."], "hard_negative": "Lymphadenopathy is observed in knockin mouse lacking the SHP-2 MAPK pathway."}
{"query_id": "742", "query_text": "Macrolides have no protective effect against myocardial infarction.", "negative": "APOE4 expression in iPSC-derived neurons increases AlphaBeta production and tau phosphorylation causing GABA neuron degeneration.", "negatives": ["APOE4 expression in iPSC-derived neurons increases AlphaBeta production and tau phosphorylation causing GABA neuron degeneration.", "Dexamethasone decreases risk of postoperative bleeding.", "Thigh-length graduated compression stockings (GCS) did not reduce deep vein thrombosis in patients admitted to hospital who are immobile because of acute stroke.", "Hyperfibrinogenemia decreases rates of femoropopliteal bypass thrombosis.", "Pleiotropic coupling of GLP-1R to intracellular effectors promotes distinct profiles of cellular signaling.", "Microarray results from culture-amplified mixtures of serotypes correlate poorly with microarray results from uncultured mixtures.", "Obesity decreases life quality.", "High-sensitivity cardiac troponin T (HSCT-T) dosage may not be diagnostic if the onset of symptoms occurs less than 3 hours before acute myocardial injury (AMI).", "Less than 10% of the gabonese children with Schimmelpenning-Feuerstein-Mims syndrome (SFM) had a plasma lactate of more than 5mmol/L.", "CR is associated with higher methylation age."], "hard_negatives": ["Macrolides have no protective effect against myocardial infarction.", "Macrolides protect against myocardial infarction.", "LDL cholesterol has no involvement in the development of cardiovascular disease.", "Flexible molecules experience greater steric hindrance in the tumor microenviroment than rigid molecules.", "Functional consequences of genomic alterations due to Myelodysplastic syndrome (MDS) are poorly understood due to the lack of an animal model.", "Mice that lack Interferon-\u03b3 or its receptor exhibit high resistance to experimental autoimmune myocarditis.", "Angiotensin converting enzyme inhibitors are associated with increased risk for functional renal insufficiency.", "Diabetic patients with acute coronary syndrome experience increased short-term and long-term risk for bleeding events.", "Ribosomopathies have a low degree of cell and tissue specific pathology.", "Increased vessel density along with a reduction in fibrosis decreases the efficacy of chemotherapy treatments."], "hard_negative": "Macrolides have no protective effect against myocardial infarction."}
{"query_id": "743", "query_text": "Macrolides protect against myocardial infarction.", "negative": "Tetraspanin-3 is a causative factor in the development of acute myelogenous leukemia", "negatives": ["Tetraspanin-3 is a causative factor in the development of acute myelogenous leukemia", "A total of 1,000 people in the UK are asymptomatic carriers of vCJD infection.", "Up-regulation of the p53 pathway and related molecular events casues cancer resistance and results in a significantly shortened lifespan marked by senescent cells and accelerated organismal aging.", "Immune responses result in the development of inflammatory Th17 cells and anti-inflammatory iTregs.", "Hypertension is frequently observed in type 1 diabetes patients.", "T regulatory cells (tTregs) lacking \u03b1v\u03b28 are more adept at suppressing pathogenic T-cell responses during active inflammation.", "Crossover hot spots are not found within gene promoters in Saccharomyces cerevisiae.", "Increased microtubule acetylation repairs LRRK2 Roc-COR domain mutation induced locomotor deficits.", "Stroke patients with prior use of direct oral anticoagulants have a lower risk of in-hospital mortality than stroke patients with prior use of warfarin.", "Mice that lack Interferon-\u03b3 or its receptor exhibit high resistance to experimental autoimmune myocarditis."], "hard_negatives": ["Macrolides protect against myocardial infarction.", "Macrolides have no protective effect against myocardial infarction.", "Flexible molecules experience greater steric hindrance in the tumor microenviroment than rigid molecules.", "Ribosomopathies have a low degree of cell and tissue specific pathology.", "LDL cholesterol has no involvement in the development of cardiovascular disease.", "Diabetic patients with acute coronary syndrome experience increased short-term and long-term risk for bleeding events.", "Functional consequences of genomic alterations due to Myelodysplastic syndrome (MDS) are poorly understood due to the lack of an animal model.", "Increased vessel density along with a reduction in fibrosis decreases the efficacy of chemotherapy treatments.", "Basophils counteract disease development in patients with systemic lupus erythematosus (SLE).", "Albendazole is used to treat lymphatic filariasis."], "hard_negative": "Macrolides protect against myocardial infarction."}
{"query_id": "744", "query_text": "Macropinocytosis contributes to a cell's supply of amino acids via the intracellular uptake of protein.", "negative": "Proteins synthesized at the growth cone are ubiquitinated at a higher rate than proteins from the cell body.", "negatives": ["Proteins synthesized at the growth cone are ubiquitinated at a higher rate than proteins from the cell body.", "Sildenafil improves erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.", "Obesity is determined solely by environmental factors.", "Mice defective for deoxyribonucleic acid (DNA) polymerase I (polI) reveal increased sensitivity to ionizing radiation (IR).", "Suboptimal nutrition is not predictive of chronic disease", "Sildenafil improves erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.", "Cells lacking clpC have a defect in sporulation efficiency in Bacillus subtilis.", "Replacement of histone H2A with H2A.Z slows gene activation in yeasts by stabilizing +1 nucleosomes.", "The genomic aberrations found in matasteses are very similar to those found in the primary tumor.", "Auditory entrainment is strengthened when people see congruent visual and auditory information."], "hard_negatives": ["Macropinocytosis contributes to a cell's supply of amino acids via the intracellular uptake of protein.", "Many proteins in human cells can be post-translationally modified at lysine residues via acetylation.", "Ethanol stress decreases the expression of IBP in bacteria.", "Bone marrow cells contribute to adult macrophage compartments.", "Glycolysis is one of the primary glycometabolic pathways in cells.", "Ly49Q directs the organization of neutrophil migration to inflammation sites by regulating membrane raft functions.", "Ribosomopathies have a low degree of cell and tissue specific pathology.", "Obesity is determined solely by environmental factors.", "Cells undergoing methionine restriction may activate miRNAs.", "Occupancy of ribosomes by IncRNAs do not make functional peptides."], "hard_negative": "Macropinocytosis contributes to a cell's supply of amino acids via the intracellular uptake of protein."}
{"query_id": "756", "query_text": "Many proteins in human cells can be post-translationally modified at lysine residues via acetylation.", "negative": "Macrolides protect against myocardial infarction.", "negatives": ["Macrolides protect against myocardial infarction.", "Cold exposure reduces BAT recruitment.", "Ly49Q directs the organization of neutrophil migration to inflammation sites by regulating membrane raft functions.", "The amount of publicly available DNA data doubles every 10 years.", "The extracellular domain of TMEM27 is cleaved in human beta cells.", "Deamination of cytidine to uridine on the minus strand of viral DNA results in catastrophic G-to-A mutations in the viral genome.", "Autologous transplantation of mesenchymal stem cells causes a higher rate of opportunistic infections than induction therapy with anti-interleukin-2 receptor antibodies.", "The center of the granuloma in an immune cell induces a pro-inflammatory immune response.", "Cell autonomous sex determination in somatic cells does not occur in Galliformes.", "Insulin increases risk of severe kidney failure."], "hard_negatives": ["Many proteins in human cells can be post-translationally modified at lysine residues via acetylation.", "The arm density of TatAd complexes is due to structural rearrangements within Class1 TatAd complexes such as the 'charge zipper mechanism'.", "Alizarin forms hydrogen bonds with residues involved in PGAM1 substrate binding.", "Cytosolic proteins bind to iron-responsive elements on mRNAs coding for DMT1. Cytosolic proteins bind to iron-responsive elements on mRNAs coding for proteins involved in iron uptake.", "Macropinocytosis contributes to a cell's supply of amino acids via the intracellular uptake of protein.", "Occupancy of ribosomes by IncRNAs do not make functional peptides.", "Mutations in G-Beta protein GNB2 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.", "Ribosomopathies have a low degree of cell and tissue specific pathology.", "Nanoparticles can be targeted against specific cell types by incorporating aptamers into lipid nanoparticles.", "Free histones are degraded by a Rad53-dependent mechanism once DNA has been replicated."], "hard_negative": "Many proteins in human cells can be post-translationally modified at lysine residues via acetylation."}
{"query_id": "759", "query_text": "Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have a dramatic impact in reducing malaria transmission.", "negative": "The minor G allele of FOXO3 is related to more severe symptoms of Crohn's Disease.", "negatives": ["The minor G allele of FOXO3 is related to more severe symptoms of Crohn's Disease.", "aPKCz causes tumour enhancement by affecting glutamine metabolism.", "Discrimination between the initiator and elongation tRNAs depends on the translation initiation factor IF3.", "Mice without IFN-\u03b3 or its receptor are resistant to EAM induced with \u03b1-MyHC/CFA.", "MicroRNA is involved in the regulation of Neural Stem Cell (NSC) differentiation and proliferation dynamic homeostasis", "The sliding activity of kinesin-8 protein Kip3 promotes bipolar spindle assembly.", "CX3CR1 on the Th2 cells suppresses airway inflammation.", "Rapamycin decreases the concentration of triacylglycerols in fruit flies.", "Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have a dramatic impact in reducing malaria transmission.", "ADAR1 binds to Dicer to cleave pre-miRNA."], "hard_negatives": ["Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have a dramatic impact in reducing malaria transmission.", "Antiretroviral therapy reduces rates of tuberculosis across a broad range of CD4 strata.", "Stroke patients with prior use of direct oral anticoagulants have a lower risk of in-hospital mortality than stroke patients with prior use of warfarin.", "The benefits of colchicine were achieved with effective widespread use of secondary prevention strategies such as high-dose statins.", "Epigenetic modulating agents (EMAs) modulate antitumor immune response in a cancer model system.", "New drugs for tuberculosis often do not penetrate the necrotic portion of a tuberculosis lesion in high concentrations.", "The treatment of cancer patients with co-IR blockade precipitates adverse autoimmune events.", "Varenicline monotherapy is more effective after 12 weeks of treatment compared to combination nicotine replacement therapies with varenicline or bupropion.", "The treatment of cancer patients with co-IR blockade does not cause any adverse autoimmune events.", "Sildenafil improves erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants."], "hard_negative": "Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have a dramatic impact in reducing malaria transmission."}
{"query_id": "768", "query_text": "Mercaptopurine is anabolized into the inactive methylmercaptopurine by thiopurine methyltrasnferase (TPMT).", "negative": "Leuko-increased blood increases infectious complications in red blood cell transfusion.", "negatives": ["Leuko-increased blood increases infectious complications in red blood cell transfusion.", "Diabetic patients with acute coronary syndrome experience increased short-term and long-term risk for bleeding events.", "Infection of human T-cell lymphotropic virus type 1 is most frequent in individuals of African origin.", "Ubiquitin ligase UBC13 generates a K63-linked polyubiquitin moiety at PCNA K164.", "Obesity is determined solely by environmental factors.", "All hematopoietic stem cells segregate their chromosomes randomly.", "Asymptomatic visual impairment screening in elderly populations does not lead to improved vision.", "There is no association between HNF4A mutations and diabetes risks.", "Mutations in G-Beta protein GNB2 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.", "Ly49Q directs the organization of neutrophil migration to inflammation sites by regulating membrane raft functions."], "hard_negatives": ["Mercaptopurine is anabolized into the inactive methylmercaptopurine by thiopurine methyltrasnferase (TPMT).", "Active H. pylori urease has a polymeric structure that compromises two subunits, UreA and UreB.", "S-nitrosylated GAPDH physiologically transnitrosylates histone deacetylases.", "NOX2-independent pathways can generate peroxynitrite by reacting with nitrogen intermediates.", "Alizarin forms hydrogen bonds with residues involved in PGAM1 substrate binding.", "Peroxynitrite is required for nitration of TCR/CD8.", "Omnivores produce less trimethylamine N-oxide from dietary I-carnitine than vegetarians.", "N348I mutations cause resistance to zidovudine (AZT).", "Monoclonal antibody targeting of N-cadherin inhibits metastasis.", "Metastatic colorectal cancer treated with a single agent fluoropyrimidines resulted in reduced efficacy and lower quality of life when compared with oxaliplatin-based chemotherapy in elderly patients."], "hard_negative": "Mercaptopurine is anabolized into the inactive methylmercaptopurine by thiopurine methyltrasnferase (TPMT)."}
{"query_id": "770", "query_text": "Metastatic colorectal cancer treated with a single agent fluoropyrimidines resulted in reduced efficacy and lower quality of life when compared with oxaliplatin-based chemotherapy in elderly patients.", "negative": "The genomic aberrations found in matasteses are very similar to those found in the primary tumor.", "negatives": ["The genomic aberrations found in matasteses are very similar to those found in the primary tumor.", "Gene expression does not vary appreciably across genetically identical cells.", "Cold exposure increases BAT recruitment.", "Asymptomatic visual impairment screening in elderly populations does not lead to improved vision.", "Free histones are degraded by a Rad53-dependent mechanism once DNA has been replicated.", "Hypoglycemia increases the risk of dementia.", "During the primary early antibody response activated B cells migrate toward the inner-and outer paracortical areas where oxysterol accumulation is generated by stromal cells.", "Cataract and trachoma are the primary cause of blindness in Southern Sudan.", "Leukemia associated Rho guanine nucleotide-exchange factor represses RhoA in response to SRC activation.", "HNF4A mutations can cause diabetes in mutant carriers by the age of 14 years"], "hard_negatives": ["Metastatic colorectal cancer treated with a single agent fluoropyrimidines resulted in reduced efficacy and lower quality of life when compared with oxaliplatin-based chemotherapy in elderly patients.", "The relationship between a breast cancer patient's capacity to metabolize tamoxifen and treatment outcome is dependent on the patient's genetic make-up.", "Stroke patients with prior use of direct oral anticoagulants have a lower risk of in-hospital mortality than stroke patients with prior use of warfarin.", "The treatment of cancer patients with co-IR blockade precipitates adverse autoimmune events.", "The treatment of cancer patients with co-IR blockade does not cause any adverse autoimmune events.", "Varenicline monotherapy is more effective after 12 weeks of treatment compared to combination nicotine replacement therapies with varenicline or bupropion.", "Dexamethasone decreases risk of postoperative bleeding.", "Albendazole is used to treat lymphatic filariasis.", "Mercaptopurine is anabolized into the inactive methylmercaptopurine by thiopurine methyltrasnferase (TPMT).", "Epigenetic modulating agents (EMAs) modulate antitumor immune response in a cancer model system."], "hard_negative": "Metastatic colorectal cancer treated with a single agent fluoropyrimidines resulted in reduced efficacy and lower quality of life when compared with oxaliplatin-based chemotherapy in elderly patients."}
{"query_id": "775", "query_text": "Mice defective for deoxyribonucleic acid (DNA) polymerase I (polI) reveal increased sensitivity to ionizing radiation (IR).", "negative": "CHEK2 is not associated with breast cancer.", "negatives": ["CHEK2 is not associated with breast cancer.", "Hypothalamic glutamate neurotransmission is crucial to energy balance.", "Hypocretin neurones induce panicprone state in rats.", "Insulin increases risk of severe kidney failure.", "Incidence of heart failure decreased by 10% in women since 1979.", "The PRR MDA5 has a central DExD/H RNA helices domain.", "Stroke patients with prior use of direct oral anticoagulants have a lower risk of in-hospital mortality than stroke patients with prior use of warfarin.", "Only a minority of cells survive development after differentiation into stress-resistant spores.", "PD-1 triggering on monocytes reduces IL-10 production by monocytes.", "Cells lacking clpC have a defect in sporulation efficiency in Bacillus subtilis."], "hard_negatives": ["Mice defective for deoxyribonucleic acid (DNA) polymerase I (polI) reveal increased sensitivity to ionizing radiation (IR).", "p16INK4A accumulation is  linked to an abnormal wound response caused by the microinvasive step of advanced Oral Potentially Malignant Lesions (OPMLs).", "The repair of Cas9-induced double strand breaks in human DNA is error-prone.", "Deamination of cytidine to uridine on the minus strand of viral DNA results in catastrophic G-to-A mutations in the viral genome.", "N348I mutations cause resistance to zidovudine (AZT).", "Helminths interfere with immune system control of macrophages activated by IL-4 favor Mycobacterium tuberculosis replication.", "Mercaptopurine is anabolized into the inactive methylmercaptopurine by thiopurine methyltrasnferase (TPMT).", "Ethanol stress decreases the expression of IBP in bacteria.", "Metastatic colorectal cancer treated with a single agent fluoropyrimidines resulted in reduced efficacy and lower quality of life when compared with oxaliplatin-based chemotherapy in elderly patients.", "Crosstalk between dendritic cells (DCs) and innate lymphoid cells (ILCs) is important in the regulation of intestinal homeostasis."], "hard_negative": "Mice defective for deoxyribonucleic acid (DNA) polymerase I (polI) reveal increased sensitivity to ionizing radiation (IR)."}
{"query_id": "781", "query_text": "Mice that lack Interferon-\u03b3 or its receptor exhibit high resistance to experimental autoimmune myocarditis.", "negative": "Albendazole is used to treat lymphatic filariasis.", "negatives": ["Albendazole is used to treat lymphatic filariasis.", "High cardiopulmonary fitness causes increased mortality rate.", "Diabetic patients with acute coronary syndrome experience increased short-term and long-term risk for bleeding events.", "Pleiotropic coupling of GLP-1R to intracellular effectors promotes distinct profiles of cellular signaling.", "Podocytes are motile and migrate in the presence of injury.", "Insomnia can be effectively treated with cognitive behavioral therapy.", "Transplanted human glial cells can differentiate within the host animal.", "Pseudogene PTENP1 regulates the expression of PTEN by functioning as an miRNA decoy.", "Varenicline monotherapy is more effective after 12 weeks of treatment compared to combination nicotine replacement therapies with varenicline or bupropion.", "Polymeal nutrition reduces cardiovascular mortality."], "hard_negatives": ["Mice that lack Interferon-\u03b3 or its receptor exhibit high resistance to experimental autoimmune myocarditis.", "Mice without IFN-\u03b3 or its receptor are resistant to EAM induced with \u03b1-MyHC/CFA.", "The treatment of cancer patients with co-IR blockade precipitates adverse autoimmune events.", "Reduced responsiveness to interleukin-2 in regulatory T cells is associated with greater resistance to autoimmune diseases such as Type 1 Diabetes.", "Diabetic patients with acute coronary syndrome experience increased short-term and long-term risk for bleeding events.", "The treatment of cancer patients with co-IR blockade does not cause any adverse autoimmune events.", "Deletion of \u03b1v\u03b28 does not result in a spontaneous inflammatory phenotype.", "IRG1 has antiviral effects against neurotropic viruses.", "High levels of CRP reduces the risk of exacerbations in chronic obstructive pulmonary disease (COPD).", "Antiretroviral therapy reduces rates of tuberculosis across a broad range of CD4 strata."], "hard_negative": "Mice that lack Interferon-\u03b3 or its receptor exhibit high resistance to experimental autoimmune myocarditis."}
{"query_id": "783", "query_text": "Mice without IFN-\u03b3 or its receptor are resistant to EAM induced with \u03b1-MyHC/CFA.", "negative": "Ultrasound guidance significantly raises the number of traumatic procedures when attempting needle insertion.", "negatives": ["Ultrasound guidance significantly raises the number of traumatic procedures when attempting needle insertion.", "Non-invasive ventilation use should be decreased if there is inadequate response to conventional treatment.", "Patients in stable partnerships have a faster progression from HIV to AIDS.", "Cellular aging closely links to an older appearance.", "Venules have a thinner or absent smooth layer compared to arterioles.", "Cytochrome c is released from the mitochondrial intermembrane space to cytosol during apoptosis.", "Subcutaneous fat depots undergo extensive browning processes after cold exposure.", "Podocytes are motile and migrate in the presence of injury.", "Pseudogene PTENP1 regulates the expression of PTEN by functioning as an miRNA decoy.", "Inositol lipid 3-phosphatase PTEN converts Ptdlns(3,4)P 2 into phosphatidylinositol 4-phosphate."], "hard_negatives": ["Mice without IFN-\u03b3 or its receptor are resistant to EAM induced with \u03b1-MyHC/CFA.", "Mice that lack Interferon-\u03b3 or its receptor exhibit high resistance to experimental autoimmune myocarditis.", "FoxO3a activation in neuronal death is mediated by reactive oxygen species (ROS).", "The treatment of cancer patients with co-IR blockade precipitates adverse autoimmune events.", "The treatment of cancer patients with co-IR blockade does not cause any adverse autoimmune events.", "Reduced responsiveness to interleukin-2 in regulatory T cells is associated with greater resistance to autoimmune diseases such as Type 1 Diabetes.", "The minor G allele of FOXO3 is related to more severe symptoms of Crohn's Disease.", "There is no association between HNF4A mutations and diabetes risks.", "A high microerythrocyte count raises vulnerability to severe anemia in homozygous alpha (+)- thalassemia trait subjects.", "Leukemia associated Rho guanine nucleotide-exchange factor represses RhoA in response to SRC activation."], "hard_negative": "Mice without IFN-\u03b3 or its receptor are resistant to EAM induced with \u03b1-MyHC/CFA."}
{"query_id": "784", "query_text": "MicroRNA is involved in the regulation of Neural Stem Cell (NSC) differentiation and proliferation dynamic homeostasis", "negative": "Articles published in open access format are more likely to be cited than traditional journals.", "negatives": ["Articles published in open access format are more likely to be cited than traditional journals.", "The tip of the inner tube of the toxic type VI secretion system (T6SS) antibacterial effector in Escherichia coli (E. coli) carries toxic effector proteins.", "Cell autonomous sex determination in somatic cells does not occur in Galliformes.", "1/2000 in UK have abnormal PrP positivity.", "Obesity is determined solely by environmental factors.", "The myocardial lineage develops from cardiac progenitors of mesodermal origin.", "UCB T cells maintain high TCR diversity after transplantation.", "Silencing of Bcl2 is important for the maintenance and progression of tumors.", "The amount of publicly available DNA data doubles every 10 years.", "IRG1 has antiviral effects against neurotropic viruses."], "hard_negatives": ["MicroRNA is involved in the regulation of Neural Stem Cell (NSC) differentiation and proliferation dynamic homeostasis", "NR5A2 is important in development of endometrial tissues.", "Ly49Q directs the organization of neutrophil migration to inflammation sites by regulating membrane raft functions.", "Tumor necrosis factor alpha (TNF-\u03b1) and interleukin-1 (IL-1) are pro-inflammatory cytokines that inhibit IL-6 and IL-10.", "Pseudogene PTENP1 regulates the expression of PTEN by functioning as an miRNA decoy.", "TNFAIP3 is a tumor suppressor in glioblastoma.", "TCR/CD3 microdomains are a required to induce the immunologic synapse to activate T cells.", "Low expression of miR7a exerts a biological function in testis.", "Reduced responsiveness to interleukin-2 in regulatory T cells is associated with greater resistance to autoimmune diseases such as Type 1 Diabetes.", "Modifying the epigenome in the brain affects the normal human aging process by affecting certain genes related to neurogenesis."], "hard_negative": "MicroRNA is involved in the regulation of Neural Stem Cell (NSC) differentiation and proliferation dynamic homeostasis"}
{"query_id": "785", "query_text": "Microarray results from culture-amplified mixtures of serotypes correlate poorly with microarray results from uncultured mixtures.", "negative": "The genomic aberrations found in matasteses are very similar to those found in the primary tumor.", "negatives": ["The genomic aberrations found in matasteses are very similar to those found in the primary tumor.", "Replacement of histone H2A with H2A.Z slows gene activation in yeasts by stabilizing +1 nucleosomes.", "NOX2-independent pathways can generate peroxynitrite by reacting with nitrogen intermediates.", "Vitamin D deficiency is unrelated to birth weight.", "The ureABIEFGH gene cluster encodes urease maturation proteins : UreD/UreH, UreE, UreF, and UreG.", "GATA-3 is important for hematopoietic stem cell (HSC) function.", "Headaches are not correlated with cognitive impairment.", "Cellular aging closely links to an older appearance.", "Ly6C hi monocytes have a lower inflammatory capacity compared to their Ly6C lo counterparts.", "1,000 genomes project enables mapping of genetic sequence variation consisting of rare variants with larger penetrance effects than common variants."], "hard_negatives": ["Microarray results from culture-amplified mixtures of serotypes correlate poorly with microarray results from uncultured mixtures.", "De novo assembly of sequence data has more specific contigs than unassembled sequence data.", "Gene expression does not vary appreciably across genetically identical cells.", "1,000 genomes project enables mapping of genetic sequence variation consisting of rare variants with larger penetrance effects than common variants.", "In domesticated populations of Saccharomyces cerevisiae, whole chromosome aneuploidy is very uncommon.", "Functional consequences of genomic alterations due to Myelodysplastic syndrome (MDS) are poorly understood due to the lack of an animal model.", "Low nucleosome occupancy correlates with low methylation levels across species.", "In mice, P. chabaudi parasites are able to proliferate faster early in infection when inoculated at lower numbers than when inoculated at high numbers.", "Lupus-prone mice infected with curliproducing bacteria have higher autoantibody titers compared to controls.", "A high microerythrocyte count raises vulnerability to severe anemia in homozygous alpha (+)- thalassemia trait subjects."], "hard_negative": "Microarray results from culture-amplified mixtures of serotypes correlate poorly with microarray results from uncultured mixtures."}
{"query_id": "793", "query_text": "Mitochondria are uninvolved in apoptosis.", "negative": "NOX2-independent pathways can generate peroxynitrite by reacting with nitrogen intermediates.", "negatives": ["NOX2-independent pathways can generate peroxynitrite by reacting with nitrogen intermediates.", "CHEK2 is not associated with breast cancer.", "IFIT1 restricts viral replication by sequestrating mis-capped viral RNAs.", "Cells lacking clpC have a defect in sporulation efficiency in Bacillus subtilis.", "Articles published in open access format are more likely to be cited than traditional journals.", "The risk of breast cancer among parous women increases with placental weight of pregnancies, and this association is strongest for premenopausal breast cancer.", "Helminths interfere with immune system control of macrophages activated by IL-4 favor Mycobacterium tuberculosis replication.", "Increased microtubule acetylation repairs LRRK2 Roc-COR domain mutation induced locomotor deficits.", "Cells lacking clpC have a defect in sporulation efficiency in Bacillus subtilis.", "Rapid up-regulation and higher basal expression of interferon-induced genes reduce survival of granule cell neurons that are infected by West Nile virus."], "hard_negatives": ["Mitochondria are uninvolved in apoptosis.", "Cytochrome c is released from the mitochondrial intermembrane space to cytosol during apoptosis.", "Immune complex triggered cell death leads to extracellular release of neutrophil protein HMGB1.", "Activation of PPM1D suppresses p53 function.", "Glycolysis is one of the primary glycometabolic pathways in cells.", "FoxO3a activation in neuronal death is mediated by reactive oxygen species (ROS).", "Podocytes are motile and migrate in the presence of injury.", "Cells undergoing methionine restriction may activate miRNAs.", "Proteins synthesized at the growth cone are ubiquitinated at a higher rate than proteins from the cell body.", "The deregulated and prolonged activation of monocytes has deleterious effects in inflammatory diseases."], "hard_negative": "Mitochondria are uninvolved in apoptosis."}
{"query_id": "800", "query_text": "Modifying the epigenome in the brain affects the normal human aging process by affecting certain genes related to neurogenesis.", "negative": "T regulatory cells (tTregs) lacking \u03b1v\u03b28 are more adept at suppressing pathogenic T-cell responses during active inflammation.", "negatives": ["T regulatory cells (tTregs) lacking \u03b1v\u03b28 are more adept at suppressing pathogenic T-cell responses during active inflammation.", "Crossover hot spots are not found within gene promoters in Saccharomyces cerevisiae.", "The sliding activity of kinesin-8 protein Kip3 promotes bipolar spindle assembly.", "The arm density of TatAd complexes is due to structural rearrangements within Class1 TatAd complexes such as the 'charge zipper mechanism'.", "The DdrB protein from Deinococcus radiodurans is an alternative SSB.", "Localization of PIN1 in the Arabidopsis embryo does not require VPS9a", "Febrile seizures reduce the threshold for development of epilepsy.", "APOE4 expression in iPSC-derived neurons increases AlphaBeta production and tau phosphorylation causing GABA neuron degeneration.", "N-terminal cleavage increases success identifying transcription start sites.", "N-terminal cleavage increases success identifying transcription start sites."], "hard_negatives": ["Modifying the epigenome in the brain affects the normal human aging process by affecting certain genes related to neurogenesis.", "Cellular aging closely links to an older appearance.", "FoxO3a activation in neuronal death is mediated by reactive oxygen species (ROS).", "Up-regulation of the p53 pathway and related molecular events casues cancer resistance and results in a significantly shortened lifespan marked by senescent cells and accelerated organismal aging.", "Hypothalamic glutamate neurotransmission is crucial to energy balance.", "Headaches are not correlated with cognitive impairment.", "Transplanted human glial progenitor cells are incapable of forming a neural network with host animals' neurons.", "Activation of PPM1D suppresses p53 function.", "Reduced responsiveness to interleukin-2 in regulatory T cells is associated with greater resistance to autoimmune diseases such as Type 1 Diabetes.", "Epigenetic modulating agents (EMAs) modulate antitumor immune response in a cancer model system."], "hard_negative": "Modifying the epigenome in the brain affects the normal human aging process by affecting certain genes related to neurogenesis."}
{"query_id": "805", "query_text": "Monoclonal antibody targeting of N-cadherin inhibits metastasis.", "negative": "Women with a higher birth weight are more likely to develop breast cancer later in life.", "negatives": ["Women with a higher birth weight are more likely to develop breast cancer later in life.", "Incidence of heart failure decreased by 10% in women since 1979.", "The treatment of cancer patients with co-IR blockade precipitates adverse autoimmune events.", "Febrile seizures reduce the threshold for development of epilepsy.", "Gene expression does not vary appreciably across genetically identical cells.", "Febrile seizures reduce the threshold for development of epilepsy.", "The center of the granuloma in an immune cell induces a pro-inflammatory immune response.", "Angiotensin converting enzyme inhibitors are associated with increased risk for functional renal insufficiency.", "Homozygous deletion of murine Sbds gene from osterix-expressing mesenchymal stem and progenitor cells (MPCs) prevents oxidative stress.", "Taking 400mg of \u03b1-tocopheryl acetate helps to prevent prostate cancer."], "hard_negatives": ["Monoclonal antibody targeting of N-cadherin inhibits metastasis.", "Sildenafil improves erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.", "The relationship between a breast cancer patient's capacity to metabolize tamoxifen and treatment outcome is dependent on the patient's genetic make-up.", "N348I mutations cause resistance to zidovudine (AZT).", "The treatment of cancer patients with co-IR blockade precipitates adverse autoimmune events.", "The treatment of cancer patients with co-IR blockade does not cause any adverse autoimmune events.", "Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have a dramatic impact in reducing malaria transmission.", "Dexamethasone decreases risk of postoperative bleeding.", "Mercaptopurine is anabolized into the inactive methylmercaptopurine by thiopurine methyltrasnferase (TPMT).", "Metastatic colorectal cancer treated with a single agent fluoropyrimidines resulted in reduced efficacy and lower quality of life when compared with oxaliplatin-based chemotherapy in elderly patients."], "hard_negative": "Monoclonal antibody targeting of N-cadherin inhibits metastasis."}
{"query_id": "808", "query_text": "Most termination events in Okazaki fragments are sequence specific.", "negative": "The sliding activity of kinesin-8 protein Kip3 promotes bipolar spindle assembly.", "negatives": ["The sliding activity of kinesin-8 protein Kip3 promotes bipolar spindle assembly.", "The binding orientation of the ML-SA1 activator at hTRPML2 is different from the binding orientation of the ML-SA1 activator at hTRPML1.", "Free histones are degraded by a Rad53-dependent mechanism once DNA has been replicated.", "Infection of human T-cell lymphotropic virus type 1 is most frequent in individuals of African origin.", "The composition of myosin-II isoform switches from the polarizable B isoform to the more homogenous A isoform during hematopoietic differentiation.", "Crossover hot spots are not found within gene promoters in Saccharomyces cerevisiae.", "Rapid up-regulation and higher basal expression of interferon-induced genes increase survival of granule cell neurons that are infected by West Nile virus.", "Mutant mice lacking SVCT2 have greatly increased ascorbic acid levels in both brain and adrenals.", "Teaching hospitals do not provide better care than non-teaching hospitals.", "Recurrent mutations occur frequently within CTCF anchor sites adjacent to oncogenes."], "hard_negatives": ["Most termination events in Okazaki fragments are sequence specific.", "The repair of Cas9-induced double strand breaks in human DNA is error-prone.", "N-terminal cleavage reduces success identifying transcription start sites.", "Occupancy of ribosomes by IncRNAs do not make functional peptides.", "Occupancy of ribosomes by IncRNAs mirror 5 0-UTRs", "Discrimination between the initiator and elongation tRNAs depends on the translation initiation factor IF3.", "N-terminal cleavage increases success identifying transcription start sites.", "Free histones are degraded by a Rad53-dependent mechanism once DNA has been replicated.", "De novo assembly of sequence data has more specific contigs than unassembled sequence data.", "Histone demethylase recruitment and a transient decrease in histone methylation is necessary for ligand-dependent induction of transcription by nuclear receptors."], "hard_negative": "Most termination events in Okazaki fragments are sequence specific."}
{"query_id": "811", "query_text": "Mutant mice lacking SVCT2 have greatly increased ascorbic acid levels in both brain and adrenals.", "negative": "Monoclonal antibody targeting of N-cadherin inhibits metastasis.", "negatives": ["Monoclonal antibody targeting of N-cadherin inhibits metastasis.", "High levels of copeptin decrease risk of diabetes.", "NFAT4 activation requires IP3R-mediated Ca2+ mobilization.", "Lack of clpC does not affect sporulation efficiency in Bacillus subtilis cells.", "Enhanced early production of inflammatory chemokines improves viral control in the lung.", "NR5A2 is important in development of endometrial tissues.", "T regulatory cells (tTregs) lacking \u03b1v\u03b28 are more adept at suppressing pathogenic T-cell responses during active inflammation.", "New drugs for tuberculosis often do not penetrate the necrotic portion of a tuberculosis lesion in high concentrations.", "Low expression of miR7a exerts a biological function in testis.", "CX3CR1 on the Th2 cells impairs T cell survival"], "hard_negatives": ["Mutant mice lacking SVCT2 have greatly increased ascorbic acid levels in both brain and adrenals.", "mTORC2 regulates intracellular cysteine levels through xCT inhibition.", "High dietary calcium intakes are unnecessary for prevention of secondary hyperparathyroidism in subjects with 25(OH)D levels above 75 nmol/liter.", "A deficiency of vitamin B12 increases blood levels of homocysteine.", "In mouse models, the loss of CSF1R facilitates MOZ-TIF2-induced leuekmogenesis.", "Mice that lack Interferon-\u03b3 or its receptor exhibit high resistance to experimental autoimmune myocarditis.", "Lupus-prone mice infected with curliproducing bacteria have higher autoantibody titers compared to controls.", "Upregulation of mosGCTL-1 is induced upon infection with West Nile virus.", "Hypertension is frequently observed in type 1 diabetes patients.", "Aspirin inhibits the production of PGE2."], "hard_negative": "Mutant mice lacking SVCT2 have greatly increased ascorbic acid levels in both brain and adrenals."}
{"query_id": "814", "query_text": "Mutations in G-Beta protein GNB2 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.", "negative": "Discrimination between the initiator and elongation tRNAs depends on the translation initiation factor IF3.", "negatives": ["Discrimination between the initiator and elongation tRNAs depends on the translation initiation factor IF3.", "Podocytes are motile and migrate in the presence of injury.", "Inositol lipid 3-phosphatase PTEN converts Ptdlns(3,4)P 2 into phosphatidylinositol 4-phosphate.", "Combination nicotine replacement therapies with varenicline or bupropion lead to significantly higher long-term abstinence rates at 52 weeks than varenicline monotherapy.", "Ultrasound guidance significantly raises the number of traumatic procedures when attempting needle insertion.", "High dietary calcium intakes are unnecessary for prevention of secondary hyperparathyroidism in subjects with 25(OH)D levels above 75 nmol/liter.", "Autologous transplantation of mesenchymal stem cells causes fewer opportunistic infections than induction therapy with anti-interleukin-2 receptor antibodies.", "The tip of the inner tube of the toxic type VI secretion system (T6SS) antibacterial effector in Escherichia coli (E. coli) carries toxic effector proteins.", "Rapid phosphotransfer rates govern fidelity in two component systems", "Pleiotropic coupling of GLP-1R to intracellular effectors promotes distinct profiles of cellular signaling."], "hard_negatives": ["Mutations in G-Beta protein GNB2 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.", "A deficiency of vitamin B12 increases blood levels of homocysteine.", "The extracellular domain of TMEM27 is cleaved in human beta cells.", "The ureABIEFGH gene cluster is induced by nickel (II) ion.", "The minor G allele of FOXO3 is related to more severe symptoms of Crohn's Disease.", "Pyridostatin destabilizes the G - quadruplex in the telomeric region.", "IgA plasma cells that are specific for transglutaminase 2 accumulate in the duodenal mucosa on commencement of a gluten-free diet.", "Deamination of cytidine to uridine on the minus strand of viral DNA results in catastrophic G-to-A mutations in the viral genome.", "There is no association between HNF4A mutations and diabetes risks.", "Arginine 90 in p150n is important for interaction with EB1."], "hard_negative": "Mutations in G-Beta protein GNB2 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway."}
{"query_id": "820", "query_text": "N-terminal cleavage increases success identifying transcription start sites.", "negative": "LDL cholesterol has no involvement in the development of cardiovascular disease.", "negatives": ["LDL cholesterol has no involvement in the development of cardiovascular disease.", "Downregulation and mislocalization of Scribble prevents cell transformation and mammary tumorigenesis.", "The ureABIEFGH gene cluster is induced by nickel (II) ion.", "Errors in peripheral IV drug administration are most common during bolus administration and multiple-step medicine preparations.", "Lack of clpC does not affect sporulation efficiency in Bacillus subtilis cells.", "In domesticated populations of Saccharomyces cerevisiae, whole chromosome aneuploidy is very uncommon.", "Hypertension is frequently observed in type 1 diabetes patients.", "Polymeal nutrition reduces cardiovascular mortality.", "Vitamin D deficiency is unrelated to birth weight.", "Up-regulation of the p53 pathway and related molecular events casues cancer resistance and results in a significantly shortened lifespan marked by senescent cells and accelerated organismal aging."], "hard_negatives": ["N-terminal cleavage increases success identifying transcription start sites.", "N-terminal cleavage reduces success identifying transcription start sites.", "Histone demethylase recruitment and a transient decrease in histone methylation is necessary for ligand-dependent induction of transcription by nuclear receptors.", "Discrimination between the initiator and elongation tRNAs depends on the translation initiation factor IF3.", "Most termination events in Okazaki fragments are sequence specific.", "Low nucleosome occupancy correlates with low methylation levels across species.", "Occupancy of ribosomes by IncRNAs mirror 5 0-UTRs", "Activation of PPM1D suppresses p53 function.", "Replacement of histone H2A with H2A.Z slows gene activation in yeasts by stabilizing +1 nucleosomes.", "Cells undergoing methionine restriction may activate miRNAs."], "hard_negative": "N-terminal cleavage increases success identifying transcription start sites."}
{"query_id": "821", "query_text": "N-terminal cleavage reduces success identifying transcription start sites.", "negative": "1/2000 in UK have abnormal PrP positivity.", "negatives": ["1/2000 in UK have abnormal PrP positivity.", "The minor G allele of FOXO3 is related to more severe symptoms of Crohn's Disease.", "Inositol lipid 3-phosphatase PTEN converts Ptdlns(3,4)P 2 into phosphatidylinositol 4-phosphate.", "A high microerythrocyte count raises vulnerability to severe anemia in homozygous alpha (+)- thalassemia trait subjects.", "Cell autonomous sex determination in somatic cells does not occur in Galliformes.", "CX3CR1 on the Th2 cells suppresses airway inflammation.", "Cell autonomous sex determination in somatic cells occurs in Passeriformes.", "CX3CR1 on the Th2 cells promotes airway inflammation.", "Macrolides protect against myocardial infarction.", "The minor G allele of FOXO3 is related to more severe symptoms of Crohn's Disease."], "hard_negatives": ["N-terminal cleavage reduces success identifying transcription start sites.", "N-terminal cleavage increases success identifying transcription start sites.", "Histone demethylase recruitment and a transient decrease in histone methylation is necessary for ligand-dependent induction of transcription by nuclear receptors.", "Discrimination between the initiator and elongation tRNAs depends on the translation initiation factor IF3.", "Most termination events in Okazaki fragments are sequence specific.", "Low nucleosome occupancy correlates with low methylation levels across species.", "Activation of PPM1D suppresses p53 function.", "Occupancy of ribosomes by IncRNAs mirror 5 0-UTRs", "Cells undergoing methionine restriction may activate miRNAs.", "Replacement of histone H2A with H2A.Z slows gene activation in yeasts by stabilizing +1 nucleosomes."], "hard_negative": "N-terminal cleavage reduces success identifying transcription start sites."}
{"query_id": "823", "query_text": "N348I mutations cause resistance to zidovudine (AZT).", "negative": "Incidence rates of cervical cancer have increased due to nationwide screening programs based primarily on cytology to detect uterine cervical cancer.", "negatives": ["Incidence rates of cervical cancer have increased due to nationwide screening programs based primarily on cytology to detect uterine cervical cancer.", "Macropinocytosis contributes to a cell's supply of amino acids via the intracellular uptake of protein.", "Homozygous deletion of murine Sbds gene from osterix-expressing mesenchymal stem and progenitor cells (MPCs) prevents oxidative stress.", "New drugs for tuberculosis often do not penetrate the necrotic portion of a tuberculosis lesion in high concentrations.", "In transgenic mice harboring green florescent protein under the control of the Sox2 promoter, less than ten percent of the cells with green florescent colocalize with cell proliferation markers.", "Leuko-increased blood increases infectious complications in red blood cell transfusion.", "Incidence rates of cervical cancer have decreased.", "NF2 (Merlin) prevents phosphorylation and subsequent cytoplasmic sequestration of YAP in Drosophila.", "Insulin increases risk of severe kidney failure.", "Activation of PPM1D suppresses p53 function."], "hard_negatives": ["N348I mutations cause resistance to zidovudine (AZT).", "Deletion of \u03b1v\u03b28 does not result in a spontaneous inflammatory phenotype.", "Deamination of cytidine to uridine on the minus strand of viral DNA results in catastrophic G-to-A mutations in the viral genome.", "The PPR MDA5 has two N-terminal CARD domains.", "Arginine 90 in p150n is important for interaction with EB1.", "Monoclonal antibody targeting of N-cadherin inhibits metastasis.", "Ubiquitin ligase UBC13 generates a K63-linked polyubiquitin moiety at PCNA K164.", "HNF4A mutations can cause diabetes in mutant carriers by the age of 14 years", "Mercaptopurine is anabolized into the inactive methylmercaptopurine by thiopurine methyltrasnferase (TPMT).", "There is no association between HNF4A mutations and diabetes risks."], "hard_negative": "N348I mutations cause resistance to zidovudine (AZT)."}
{"query_id": "830", "query_text": "NF2 (Merlin) causes phosphorylation and subsequent cytoplasmic sequestration of YAP in Drosophila by activating LATS1/2 kinases.", "negative": "Carriers of the alcohol aldehyde dehydrogenase deficiency mutation drink less that non-carries.", "negatives": ["Carriers of the alcohol aldehyde dehydrogenase deficiency mutation drink less that non-carries.", "MicroRNA is involved in the regulation of Neural Stem Cell (NSC) differentiation and proliferation dynamic homeostasis", "Normal expression of RUNX1 has tumor-promoting effects.", "APOE4 expression in iPSC-derived neurons increases AlphaBeta production and tau phosphorylation causing GABA neuron degeneration.", "ITAM phosphorylation prevents the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).", "A deficiency of vitamin B12 increases blood levels of homocysteine.", "The benefits of colchicine were achieved with effective widespread use of secondary prevention strategies such as high-dose statins.", "p16INK4A accumulation is  linked to an abnormal wound response caused by the microinvasive step of advanced Oral Potentially Malignant Lesions (OPMLs).", "Recurrent mutations occur frequently within CTCF anchor sites adjacent to oncogenes.", "The tip of the inner tube of the toxic type VI secretion system (T6SS) antibacterial effector in Escherichia coli (E. coli) carries toxic effector proteins."], "hard_negatives": ["NF2 (Merlin) causes phosphorylation and subsequent cytoplasmic sequestration of YAP in Drosophila by activating LATS1/2 kinases.", "NF2 (Merlin) prevents phosphorylation and subsequent cytoplasmic sequestration of YAP in Drosophila.", "ITAM phosphorylation prevents the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).", "FoxO3a activation in neuronal death is mediated by reactive oxygen species (ROS).", "APOE4 expression in iPSC-derived neurons increases AlphaBeta production and tau phosphorylation, delaying GABA neuron degeneration.", "TNFAIP3 is a tumor suppressor in glioblastoma.", "Replacement of histone H2A with H2A.Z slows gene activation in yeasts by stabilizing +1 nucleosomes.", "Blocking the interaction between TDP-43 and respiratory complex I proteins ND3 and ND6 leads to increased TDP-43-induced neuronal loss.", "APOE4 expression in iPSC-derived neurons increases AlphaBeta production and tau phosphorylation causing GABA neuron degeneration.", "Cytosolic proteins bind to iron-responsive elements on mRNAs coding for DMT1. Cytosolic proteins bind to iron-responsive elements on mRNAs coding for proteins involved in iron uptake."], "hard_negative": "NF2 (Merlin) causes phosphorylation and subsequent cytoplasmic sequestration of YAP in Drosophila by activating LATS1/2 kinases."}
{"query_id": "831", "query_text": "NF2 (Merlin) prevents phosphorylation and subsequent cytoplasmic sequestration of YAP in Drosophila.", "negative": "Alizarin forms hydrogen bonds with residues involved in PGAM1 substrate binding.", "negatives": ["Alizarin forms hydrogen bonds with residues involved in PGAM1 substrate binding.", "AMP-activated protein kinase (AMPK) activation increases inflammation-related fibrosis in the lungs.", "Cellular aging closely links to an older appearance.", "Primary cervical cancer screening with HPV detection has higher longitudinal sensitivity than conventional cytology to detect cervical intraepithelial neoplasia grade 2.", "Ethanol stress decreases the expression of IBP in bacteria.", "NF2 (Merlin) causes phosphorylation and subsequent cytoplasmic sequestration of YAP in Drosophila by activating LATS1/2 kinases.", "The extracellular domain of TMEM27 is cleaved in human beta cells.", "Deletion of \u03b1v\u03b28 does not result in a spontaneous inflammatory phenotype.", "Teaching hospitals do not provide better care than non-teaching hospitals.", "The extracellular domain of TMEM27 is cleaved in human beta cells."], "hard_negatives": ["NF2 (Merlin) prevents phosphorylation and subsequent cytoplasmic sequestration of YAP in Drosophila.", "NF2 (Merlin) causes phosphorylation and subsequent cytoplasmic sequestration of YAP in Drosophila by activating LATS1/2 kinases.", "FoxO3a activation in neuronal death is mediated by reactive oxygen species (ROS).", "ITAM phosphorylation prevents the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).", "Replacement of histone H2A with H2A.Z slows gene activation in yeasts by stabilizing +1 nucleosomes.", "APOE4 expression in iPSC-derived neurons increases AlphaBeta production and tau phosphorylation, delaying GABA neuron degeneration.", "TNFAIP3 is a tumor suppressor in glioblastoma.", "Blocking the interaction between TDP-43 and respiratory complex I proteins ND3 and ND6 leads to increased TDP-43-induced neuronal loss.", "APOE4 expression in iPSC-derived neurons increases AlphaBeta production and tau phosphorylation causing GABA neuron degeneration.", "The ureABIEFGH gene cluster is induced by nickel (II) ion."], "hard_negative": "NF2 (Merlin) prevents phosphorylation and subsequent cytoplasmic sequestration of YAP in Drosophila."}
{"query_id": "832", "query_text": "NFAT4 activation requires IP3R-mediated Ca2+ mobilization.", "negative": "Mercaptopurine is anabolized into the inactive methylmercaptopurine by thiopurine methyltrasnferase (TPMT).", "negatives": ["Mercaptopurine is anabolized into the inactive methylmercaptopurine by thiopurine methyltrasnferase (TPMT).", "Tirasemtiv has no effect on fast-twitch muscle.", "Non-invasive ventilation use should be decreased if there is inadequate response to conventional treatment.", "Only a minority of cells survive development after differentiation into stress-resistant spores.", "0-dimensional biomaterials show inductive properties.", "Downregulation and mislocalization of Scribble prevents cell transformation and mammary tumorigenesis.", "Arginine 90 in p150n is important for interaction with EB1.", "Ivermectin is used to treat lymphatic filariasis.", "Ultrasound guidance significantly raises the number of traumatic procedures when attempting needle insertion.", "Autologous transplantation of mesenchymal stem cells causes fewer opportunistic infections than induction therapy with anti-interleukin-2 receptor antibodies."], "hard_negatives": ["NFAT4 activation requires IP3R-mediated Ca2+ mobilization.", "Cytochrome c is released from the mitochondrial intermembrane space to cytosol during apoptosis.", "mTORC2 regulates intracellular cysteine levels through xCT inhibition.", "FoxO3a activation in neuronal death is mediated by reactive oxygen species (ROS).", "ITAM phosphorylation prevents the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).", "PD-1 triggering on monocytes reduces IL-10 production by monocytes.", "APOE4 expression in iPSC-derived neurons increases AlphaBeta production and tau phosphorylation, delaying GABA neuron degeneration.", "The extracellular domain of TMEM27 is cleaved in human beta cells.", "Activation of PPM1D suppresses p53 function.", "Smc5/6 engagment drives the activation of SUMO E3 ligase Mms21 by ATP-dependent remolding."], "hard_negative": "NFAT4 activation requires IP3R-mediated Ca2+ mobilization."}
{"query_id": "834", "query_text": "NOX2-independent pathways can generate peroxynitrite by reacting with nitrogen intermediates.", "negative": "Hypothalamic glutamate neurotransmission is crucial to energy balance.", "negatives": ["Hypothalamic glutamate neurotransmission is crucial to energy balance.", "Ubiquitin ligase UBC13 generates a K63-linked polyubiquitin moiety at PCNA K164.", "Enhanced early production of inflammatory chemokines improves viral control in the lung.", "The binding orientation of the ML-SA1 activator at hTRPML2 is different from the binding orientation of the ML-SA1 activator at hTRPML1.", "Histone demethylase recruitment and a transient decrease in histone methylation is necessary for ligand-dependent induction of transcription by nuclear receptors.", "Podocytes are motile and migrate in the presence of injury.", "Nanoparticles can be targeted against specific cell types by incorporating aptamers into lipid nanoparticles.", "DMRT1 is a sex-determining gene that is epigenetically regulated by the MHM region.", "Bone marrow cells contribute to adult macrophage compartments.", "Localization of PIN1 in the Arabidopsis embryo does not require VPS9a"], "hard_negatives": ["NOX2-independent pathways can generate peroxynitrite by reacting with nitrogen intermediates.", "Peroxynitrite is required for nitration of TCR/CD8.", "Active H. pylori urease has a polymeric structure that compromises two subunits, UreA and UreB.", "Mercaptopurine is anabolized into the inactive methylmercaptopurine by thiopurine methyltrasnferase (TPMT).", "Replacement of histone H2A with H2A.Z slows gene activation in yeasts by stabilizing +1 nucleosomes.", "The ureABIEFGH gene cluster is induced by nickel (II) ion.", "Omnivores produce less trimethylamine N-oxide from dietary I-carnitine than vegetarians.", "S-nitrosylated GAPDH physiologically transnitrosylates histone deacetylases.", "FoxO3a activation in neuronal death is mediated by reactive oxygen species (ROS).", "A deficiency of vitamin B12 increases blood levels of homocysteine."], "hard_negative": "NOX2-independent pathways can generate peroxynitrite by reacting with nitrogen intermediates."}
{"query_id": "837", "query_text": "NR5A2 is important in development of endometrial tissues.", "negative": "The treatment of cancer patients with co-IR blockade precipitates adverse autoimmune events.", "negatives": ["The treatment of cancer patients with co-IR blockade precipitates adverse autoimmune events.", "Arginine 90 in p150n is important for interaction with EB1.", "The risk of breast cancer among parous women increases with placental weight of pregnancies, and this association is strongest for premenopausal breast cancer.", "Asymptomatic visual impairment screening in elderly populations does not lead to improved vision.", "Auditory entrainment is strengthened when people see congruent visual and auditory information.", "Cataract and trachoma are the primary cause of blindness in Southern Sudan.", "Ivermectin is used to treat onchocerciasis.", "Ethanol stress decreases the expression of IBP in bacteria.", "The loss of the TET protein functions may have dire biological consequences, such as myeloid cancers.", "Modifying the epigenome in the brain affects the normal human aging process by affecting certain genes related to neurogenesis."], "hard_negatives": ["NR5A2 is important in development of endometrial tissues.", "CHEK2 is not associated with breast cancer.", "MicroRNA is involved in the regulation of Neural Stem Cell (NSC) differentiation and proliferation dynamic homeostasis", "Arginine 90 in p150n is important for interaction with EB1.", "PDPN promotes efficient motility along stromal surfaces by activating the C-type lectin receptor to rearrange the actin cytoskeleton in dendritic cells.", "Mutations in G-Beta protein GNB2 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.", "ALDH1 expression is associated with better breast cancer outcomes.", "The locus rs647161 is associated with colorectal carcinoma.", "GATA-3 is important for hematopoietic stem cell (HSC) function.", "TNFAIP3 is a tumor suppressor in glioblastoma."], "hard_negative": "NR5A2 is important in development of endometrial tissues."}
{"query_id": "839", "query_text": "Nanoparticles can be targeted against specific cell types by incorporating aptamers into lipid nanoparticles.", "negative": "Birth-weight is positively associated with breast cancer.", "negatives": ["Birth-weight is positively associated with breast cancer.", "Cataract and trachoma are the primary cause of blindness in Southern Sudan.", "The DdrB protein from Deinococcus radiodurans is an alternative SSB.", "Upregulation of mosGCTL-1 is induced upon infection with West Nile virus.", "Metastatic colorectal cancer treated with a single agent fluoropyrimidines resulted in reduced efficacy and lower quality of life when compared with oxaliplatin-based chemotherapy in elderly patients.", "1/2000 in UK have abnormal PrP positivity.", "aPKCz causes tumour enhancement by affecting glutamine metabolism.", "ALDH1 expression is associated with poorer prognosis in breast cancer.", "Mice defective for deoxyribonucleic acid (DNA) polymerase I (polI) reveal increased sensitivity to ionizing radiation (IR).", "Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have a dramatic impact in reducing malaria transmission."], "hard_negatives": ["Nanoparticles can be targeted against specific cell types by incorporating aptamers into lipid nanoparticles.", "Flexible molecules experience greater steric hindrance in the tumor microenviroment than rigid molecules.", "0-dimensional biomaterials show inductive properties.", "Epigenetic modulating agents (EMAs) modulate antitumor immune response in a cancer model system.", "Proteins synthesized at the growth cone are ubiquitinated at a higher rate than proteins from the cell body.", "Many proteins in human cells can be post-translationally modified at lysine residues via acetylation.", "Inositol lipid 3-phosphatase PTEN converts Ptdlns(3,4)P 2 into phosphatidylinositol 4-phosphate.", "Neutrophil extracellular traps (NETs) are released by ANCA-stimulated neutrophils.", "Venules have a thinner or absent smooth layer compared to arterioles.", "The loss of the TET protein functions may have dire biological consequences, such as myeloid cancers."], "hard_negative": "Nanoparticles can be targeted against specific cell types by incorporating aptamers into lipid nanoparticles."}
{"query_id": "845", "query_text": "Neutrophil extracellular traps (NETs) are released by ANCA-stimulated neutrophils.", "negative": "Synaptic activity enhances local release of brain derived neurotrophic factor from postsynaptic dendrites.", "negatives": ["Synaptic activity enhances local release of brain derived neurotrophic factor from postsynaptic dendrites.", "All hematopoietic stem cells segregate their chromosomes randomly.", "The ureABIEFGH gene cluster encodes urease maturation proteins : UreD/UreH, UreE, UreF, and UreG.", "Deamination of cytidine to uridine on the minus strand of viral DNA results in catastrophic G-to-A mutations in the viral genome.", "CCL19 is absent within dLNs.", "The minor G allele of FOXO3 is related to more severe symptoms of Crohn's Disease.", "S-nitrosylated GAPDH physiologically transnitrosylates histone deacetylases.", "Hypertension is frequently observed in type 1 diabetes patients.", "Pseudogene PTENP1 regulates the expression of PTEN by functioning as an miRNA decoy.", "ADAR1 binds to Dicer to cleave pre-miRNA."], "hard_negatives": ["Neutrophil extracellular traps (NETs) are released by ANCA-stimulated neutrophils.", "Immune complex triggered cell death leads to extracellular release of neutrophil protein HMGB1.", "Basophils counteract disease development in patients with systemic lupus erythematosus (SLE).", "Nanoparticles can be targeted against specific cell types by incorporating aptamers into lipid nanoparticles.", "Epigenetic modulating agents (EMAs) modulate antitumor immune response in a cancer model system.", "Glycolysis is one of the primary glycometabolic pathways in cells.", "The center of the granuloma in an immune cell induces a pro-inflammatory immune response.", "Transferred UCB T cells acquire a memory-like phenotype in recipients.", "Crosstalk between dendritic cells (DCs) and innate lymphoid cells (ILCs) is important in the regulation of intestinal homeostasis.", "IgA plasma cells that are specific for transglutaminase 2 accumulate in the duodenal mucosa on commencement of a gluten-free diet."], "hard_negative": "Neutrophil extracellular traps (NETs) are released by ANCA-stimulated neutrophils."}
{"query_id": "847", "query_text": "New drugs for tuberculosis often do not penetrate the necrotic portion of a tuberculosis lesion in high concentrations.", "negative": "Ethanol stress decreases the expression of IBP in bacteria.", "negatives": ["Ethanol stress decreases the expression of IBP in bacteria.", "AIRE is expressed in some skin tumors.", "Rapid up-regulation and higher basal expression of interferon-induced genes increase survival of granule cell neurons that are infected by West Nile virus.", "Bariatric surgery has a positive impact on mental health.", "Localization of PIN1 in the Arabidopsis embryo does not require VPS9a", "Rapamycin decreases the concentration of triacylglycerols in fruit flies.", "Transferred UCB T cells acquire a memory-like phenotype in recipients.", "Rapid phosphotransfer rates govern fidelity in two component systems", "Thigh-length graduated compression stockings (GCS) did not reduce deep vein thrombosis in patients admitted to hospital who are immobile because of acute stroke.", "Occupancy of ribosomes by IncRNAs mirror 5 0-UTRs"], "hard_negatives": ["New drugs for tuberculosis often do not penetrate the necrotic portion of a tuberculosis lesion in high concentrations.", "Antiretroviral therapy reduces rates of tuberculosis across a broad range of CD4 strata.", "Helminths interfere with immune system control of macrophages activated by IL-4 favor Mycobacterium tuberculosis replication.", "Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have a dramatic impact in reducing malaria transmission.", "Anthrax spores can be disposed of easily after they are dispersed.", "In mice, P. chabaudi parasites are able to proliferate faster early in infection when inoculated at lower numbers than when inoculated at high numbers.", "Infection of human T-cell lymphotropic virus type 1 is most frequent in individuals of African origin.", "Deletion of \u03b1v\u03b28 does not result in a spontaneous inflammatory phenotype.", "Stroke patients with prior use of direct oral anticoagulants have a lower risk of in-hospital mortality than stroke patients with prior use of warfarin.", "Increased vessel density along with a reduction in fibrosis decreases the efficacy of chemotherapy treatments."], "hard_negative": "New drugs for tuberculosis often do not penetrate the necrotic portion of a tuberculosis lesion in high concentrations."}
{"query_id": "852", "query_text": "Non-invasive ventilation use should be decreased if there is inadequate response to conventional treatment.", "negative": "TNFAIP3 is a tumor suppressor in glioblastoma.", "negatives": ["TNFAIP3 is a tumor suppressor in glioblastoma.", "Thigh-length graduated compression stockings (GCS) did not reduce deep vein thrombosis in patients admitted to hospital who are immobile because of acute stroke.", "ADAR1 binds to Dicer to cleave pre-miRNA.", "The severity of cardiac involvement in amyloidosis can be described by the degree of transmurality of late gadolinium enhancement in MRI.", "Obesity is determined solely by environmental factors.", "Sildenafil improves erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.", "All hematopoietic stem cells segregate their chromosomes randomly.", "De novo assembly of sequence data has more specific contigs than unassembled sequence data.", "In transgenic mice harboring green florescent protein under the control of the Sox2 promoter, less than ten percent of the cells with green florescent colocalize with cell proliferation markers.", "Subcutaneous fat depots undergo extensive browning processes after cold exposure."], "hard_negatives": ["Non-invasive ventilation use should be decreased if there is inadequate response to conventional treatment.", "Stroke patients with prior use of direct oral anticoagulants have a lower risk of in-hospital mortality than stroke patients with prior use of warfarin.", "Enhanced early production of inflammatory chemokines improves viral control in the lung.", "Antiretroviral therapy reduces rates of tuberculosis across a broad range of CD4 strata.", "Exposure to fine particulate air pollution is relate to anxiety prevalence.", "In young and middle-aged adults, current or remote uses of ADHD medications do not increase the risk of serious cardiovascular events.", "AMP-activated protein kinase (AMPK) activation increases inflammation-related fibrosis in the lungs.", "The treatment of cancer patients with co-IR blockade does not cause any adverse autoimmune events.", "Asymptomatic visual impairment screening in elderly populations does not lead to improved vision.", "Ultrasound guidance significantly raises the number of traumatic procedures when attempting needle insertion."], "hard_negative": "Non-invasive ventilation use should be decreased if there is inadequate response to conventional treatment."}
{"query_id": "859", "query_text": "Normal expression of RUNX1 has tumor-promoting effects.", "negative": "Lack of clpC does not affect sporulation efficiency in Bacillus subtilis cells.", "negatives": ["Lack of clpC does not affect sporulation efficiency in Bacillus subtilis cells.", "IRG1 has antiviral effects against neurotropic viruses.", "Deleting Raptor reduces G-CSF levels.", "Stroke patients with prior use of direct oral anticoagulants have a lower risk of in-hospital mortality than stroke patients with prior use of warfarin.", "Replacement of histone H2A with H2A.Z slows gene activation in yeasts by stabilizing +1 nucleosomes.", "Monoclonal antibody targeting of N-cadherin inhibits metastasis.", "Low expression of miR7a does represses target genes and exerts a biological function in ovaries.", "Integrating classroom-based collaborative learning with Web-based collaborative learning leads to subpar class performance", "Upregulation of mosGCTL-1 is induced upon infection with West Nile virus.", "Localization of PIN1 in the Arabidopsis embryo does not require VPS9a"], "hard_negatives": ["Normal expression of RUNX1 has tumor-promoting effects.", "ALDH1 expression is associated with poorer prognosis in breast cancer.", "ALDH1 expression is associated with better breast cancer outcomes.", "PGE 2 promotes intestinal tumor growth by altering the expression of tumor suppressing and DNA repair genes.", "Up-regulation of the p53 pathway and related molecular events casues cancer resistance and results in a significantly shortened lifespan marked by senescent cells and accelerated organismal aging.", "PD-1 triggering on monocytes reduces IL-10 production by monocytes.", "Activation of PPM1D suppresses p53 function.", "The locus rs647161 is associated with colorectal carcinoma.", "Breast cancer development is determined exclusively by genetic factors.", "Pseudogene PTENP1 regulates the expression of PTEN by functioning as an miRNA decoy."], "hard_negative": "Normal expression of RUNX1 has tumor-promoting effects."}
{"query_id": "870", "query_text": "Obesity decreases life quality.", "negative": "NF2 (Merlin) causes phosphorylation and subsequent cytoplasmic sequestration of YAP in Drosophila by activating LATS1/2 kinases.", "negatives": ["NF2 (Merlin) causes phosphorylation and subsequent cytoplasmic sequestration of YAP in Drosophila by activating LATS1/2 kinases.", "Therapeutic use of the drug Dapsone to treat pyoderma gangrenous is based on anecdotal evidence.", "LDL cholesterol has no involvement in the development of cardiovascular disease.", "The composition of myosin-II isoform switches from the polarizable B isoform to the more homogenous A isoform during hematopoietic differentiation.", "Suboptimal nutrition is not predictive of chronic disease", "PGE 2 promotes intestinal tumor growth by altering the expression of tumor suppressing and DNA repair genes.", "Peroxynitrite is required for nitration of TCR/CD8.", "Macrolides protect against myocardial infarction.", "Exposure to fine particulate air pollution is relate to anxiety prevalence.", "Teaching hospitals do not provide better care than non-teaching hospitals."], "hard_negatives": ["Obesity decreases life quality.", "Obesity is determined solely by environmental factors.", "High cardiopulmonary fitness causes increased mortality rate.", "Insulin increases risk of severe kidney failure.", "5% of perinatal mortality is due to low birth weight.", "Vitamin D deficiency is unrelated to birth weight.", "Suboptimal nutrition is not predictive of chronic disease", "Epidemiological disease burden from noncommunicable diseases is more prevalent in low economic settings.", "High levels of copeptin decrease risk of diabetes.", "Autophagy declines in aged organisms."], "hard_negative": "Obesity decreases life quality."}
{"query_id": "873", "query_text": "Obesity is determined solely by environmental factors.", "negative": "Leukemia associated Rho guanine nucleotide-exchange factor represses RhoA in response to SRC activation.", "negatives": ["Leukemia associated Rho guanine nucleotide-exchange factor represses RhoA in response to SRC activation.", "Increased vessel density along with a reduction in fibrosis decreases the efficacy of chemotherapy treatments.", "Activator-inhibitor pairs are provided dorsally by Admpchordin.", "Bone marrow cells contribute to adult macrophage compartments.", "Ivermectin is used to treat onchocerciasis.", "Chronic aerobic exercise alters endothelial function, improving vasodilating mechanisms mediated by NO.", "The center of the granuloma in an immune cell induces a pro-inflammatory immune response.", "Crossover hot spots are not found within gene promoters in Saccharomyces cerevisiae.", "In adult tissue, most T cells are memory T cells.", "Upregulation of mosGCTL-1 is induced upon infection with West Nile virus."], "hard_negatives": ["Obesity is determined solely by environmental factors.", "Obesity decreases life quality.", "Suboptimal nutrition is not predictive of chronic disease", "Vitamin D deficiency is unrelated to birth weight.", "5% of perinatal mortality is due to low birth weight.", "Breast cancer development is determined exclusively by genetic factors.", "Headaches are not correlated with cognitive impairment.", "Epidemiological disease burden from noncommunicable diseases is more prevalent in low economic settings.", "Birth-weight is positively associated with breast cancer.", "Hypertension is frequently observed in type 1 diabetes patients."], "hard_negative": "Obesity is determined solely by environmental factors."}
{"query_id": "879", "query_text": "Occupancy of ribosomes by IncRNAs do not make functional peptides.", "negative": "Hypothalamic glutamate neurotransmission is crucial to energy balance.", "negatives": ["Hypothalamic glutamate neurotransmission is crucial to energy balance.", "High levels of CRP reduces the risk of exacerbations in chronic obstructive pulmonary disease (COPD).", "In adult tissue, most T cells are memory T cells.", "The loss of the TET protein functions may have dire biological consequences, such as myeloid cancers.", "In domesticated populations of Saccharomyces cerevisiae, whole chromosome aneuploidy is very uncommon.", "Ly6C hi monocytes have a lower inflammatory capacity than Ly6C lo monocytes.", "Mercaptopurine is anabolized into the inactive methylmercaptopurine by thiopurine methyltrasnferase (TPMT).", "High dietary calcium intakes are unnecessary for prevention of secondary hyperparathyroidism in subjects with 25(OH)D levels above 75 nmol/liter.", "The genomic aberrations found in matasteses are very similar to those found in the primary tumor.", "Occupancy of ribosomes by IncRNAs mirror 5 0-UTRs"], "hard_negatives": ["Occupancy of ribosomes by IncRNAs do not make functional peptides.", "Occupancy of ribosomes by IncRNAs mirror 5 0-UTRs", "Ribosomopathies have a low degree of cell and tissue specific pathology.", "Many proteins in human cells can be post-translationally modified at lysine residues via acetylation.", "The arm density of TatAd complexes is due to structural rearrangements within Class1 TatAd complexes such as the 'charge zipper mechanism'.", "Most termination events in Okazaki fragments are sequence specific.", "Discrimination between the initiator and elongation tRNAs depends on the translation initiation factor IF3.", "Recurrent mutations occur frequently within CTCF anchor sites adjacent to oncogenes.", "IFIT1 restricts viral replication by sequestrating mis-capped viral RNAs.", "The PPR MDA5 has two N-terminal CARD domains."], "hard_negative": "Occupancy of ribosomes by IncRNAs do not make functional peptides."}
{"query_id": "880", "query_text": "Occupancy of ribosomes by IncRNAs mirror 5 0-UTRs", "negative": "Microarray results from culture-amplified mixtures of serotypes correlate poorly with microarray results from uncultured mixtures.", "negatives": ["Microarray results from culture-amplified mixtures of serotypes correlate poorly with microarray results from uncultured mixtures.", "The center of the granuloma in an immune cell induces a pro-inflammatory immune response.", "High dietary calcium intakes are unnecessary for prevention of secondary hyperparathyroidism in subjects with 25(OH)D levels above 75 nmol/liter.", "Smc5/6 engagment drives the activation of SUMO E3 ligase Mms21 by ATP-dependent remolding.", "Primary pro-inflammatory cytokines induce secondary pro- and anti-inflammatory mediators.", "ALDH1 expression is associated with better breast cancer outcomes.", "The US health care system can save up to $750 million if 7% of patients waiting for kidney transplants participate in the optimized national kidney paired donation program.", "0-dimensional biomaterials show inductive properties.", "Obesity is determined solely by environmental factors.", "Women with a higher birth weight are more likely to develop breast cancer later in life."], "hard_negatives": ["Occupancy of ribosomes by IncRNAs mirror 5 0-UTRs", "Occupancy of ribosomes by IncRNAs do not make functional peptides.", "The PPR MDA5 has two N-terminal CARD domains.", "The ureABIEFGH gene cluster encodes urease maturation proteins : UreD/UreH, UreE, UreF, and UreG.", "Low nucleosome occupancy correlates with low methylation levels across species.", "Discrimination between the initiator and elongation tRNAs depends on the translation initiation factor IF3.", "Ribosomopathies have a low degree of cell and tissue specific pathology.", "The ureABIEFGH gene cluster is induced by nickel (II) ion.", "The PRR MDA5 has a central DExD/H RNA helices domain.", "Most termination events in Okazaki fragments are sequence specific."], "hard_negative": "Occupancy of ribosomes by IncRNAs mirror 5 0-UTRs"}
{"query_id": "882", "query_text": "Omnivores produce less trimethylamine N-oxide from dietary I-carnitine than vegetarians.", "negative": "Ubiquitin ligase UBC13 generates a K63-linked polyubiquitin moiety at PCNA K164.", "negatives": ["Ubiquitin ligase UBC13 generates a K63-linked polyubiquitin moiety at PCNA K164.", "Macrolides protect against myocardial infarction.", "Nanoparticles can be targeted against specific cell types by incorporating aptamers into lipid nanoparticles.", "DMRT1 is a sex-determining gene that is epigenetically regulated by the MHM region.", "The availability of safe places to study is not effective at decreasing homelessness.", "Chenodeosycholic acid treatment increases whole-body energy expenditure.", "NOX2-independent pathways can generate peroxynitrite by reacting with nitrogen intermediates.", "High levels of CRP reduces the risk of exacerbations in chronic obstructive pulmonary disease (COPD).", "Homozygous deletion of murine Sbds gene from osterix-expressing mesenchymal stem and progenitor cells (MPCs) prevents oxidative stress.", "Insomnia can be effectively treated with cognitive behavioral therapy."], "hard_negatives": ["Omnivores produce less trimethylamine N-oxide from dietary I-carnitine than vegetarians.", "Mercaptopurine is anabolized into the inactive methylmercaptopurine by thiopurine methyltrasnferase (TPMT).", "Sildenafil improves erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.", "Carriers of the alcohol aldehyde dehydrogenase deficiency mutation drink less that non-carries.", "NOX2-independent pathways can generate peroxynitrite by reacting with nitrogen intermediates.", "Cytosolic proteins bind to iron-responsive elements on mRNAs coding for DMT1. Cytosolic proteins bind to iron-responsive elements on mRNAs coding for proteins involved in iron uptake.", "Active H. pylori urease has a polymeric structure that compromises two subunits, UreA and UreB.", "A deficiency of vitamin B12 increases blood levels of homocysteine.", "The benefits of colchicine were achieved with effective widespread use of secondary prevention strategies such as high-dose statins.", "High dietary calcium intakes are unnecessary for prevention of secondary hyperparathyroidism in subjects with 25(OH)D levels above 75 nmol/liter."], "hard_negative": "Omnivores produce less trimethylamine N-oxide from dietary I-carnitine than vegetarians."}
{"query_id": "887", "query_text": "Only a minority of cells survive development after differentiation into stress-resistant spores.", "negative": "Venules have a larger lumen diameter than arterioles.", "negatives": ["Venules have a larger lumen diameter than arterioles.", "New drugs for tuberculosis often do not penetrate the necrotic portion of a tuberculosis lesion in high concentrations.", "Arginine 90 in p150n is important for interaction with EB1.", "Birth-weight is positively associated with breast cancer.", "Enhanced early production of inflammatory chemokines improves viral control in the lung.", "PGE 2 promotes intestinal tumor growth by altering the expression of tumor suppressing and DNA repair genes.", "Immune responses result in the development of inflammatory Th17 cells and anti-inflammatory iTregs.", "Breast cancer development is determined exclusively by genetic factors.", "The amount of publicly available DNA data doubles every 10 years.", "N-terminal cleavage reduces success identifying transcription start sites."], "hard_negatives": ["Only a minority of cells survive development after differentiation into stress-resistant spores.", "Podocytes are motile and migrate in the presence of injury.", "Anthrax spores can be disposed of easily after they are dispersed.", "Proteins synthesized at the growth cone are ubiquitinated at a higher rate than proteins from the cell body.", "The center of the granuloma in an immune cell induces a pro-inflammatory immune response.", "In mice, P. chabaudi parasites are able to proliferate faster early in infection when inoculated at lower numbers than when inoculated at high numbers.", "Bone marrow cells contribute to adult macrophage compartments.", "Rapid up-regulation and higher basal expression of interferon-induced genes reduce survival of granule cell neurons that are infected by West Nile virus.", "Rapid up-regulation and higher basal expression of interferon-induced genes increase survival of granule cell neurons that are infected by West Nile virus.", "New drugs for tuberculosis often do not penetrate the necrotic portion of a tuberculosis lesion in high concentrations."], "hard_negative": "Only a minority of cells survive development after differentiation into stress-resistant spores."}
{"query_id": "903", "query_text": "PD-1 triggering on monocytes reduces IL-10 production by monocytes.", "negative": "Incidence rates of cervical cancer have decreased.", "negatives": ["Incidence rates of cervical cancer have decreased.", "N348I mutations cause resistance to zidovudine (AZT).", "Cells undergoing methionine restriction may activate miRNAs.", "Chronic aerobic exercise alters endothelial function, improving vasodilating mechanisms mediated by NO.", "Gene expression does not vary appreciably across genetically identical cells.", "Peroxynitrite is required for nitration of TCR/CD8.", "In mouse models, the loss of CSF1R facilitates MOZ-TIF2-induced leuekmogenesis.", "The DdrB protein from Deinococcus radiodurans is an alternative SSB.", "Lack of clpC does not affect sporulation efficiency in Bacillus subtilis cells.", "The minor G allele of FOXO3 is related to more severe symptoms of Crohn's Disease."], "hard_negatives": ["PD-1 triggering on monocytes reduces IL-10 production by monocytes.", "The deregulated and prolonged activation of monocytes has deleterious effects in inflammatory diseases.", "Reduced responsiveness to interleukin-2 in regulatory T cells is associated with greater resistance to autoimmune diseases such as Type 1 Diabetes.", "Activation of PPM1D suppresses p53 function.", "Mice that lack Interferon-\u03b3 or its receptor exhibit high resistance to experimental autoimmune myocarditis.", "Blocking the interaction between TDP-43 and respiratory complex I proteins ND3 and ND6 leads to increased TDP-43-induced neuronal loss.", "Crosstalk between dendritic cells (DCs) and innate lymphoid cells (ILCs) is important in the regulation of intestinal homeostasis.", "HNF4A mutations can cause diabetes in mutant carriers by the age of 14 years", "AMP-activated protein kinase (AMPK) activation increases inflammation-related fibrosis in the lungs.", "Deletion of \u03b1v\u03b28 does not result in a spontaneous inflammatory phenotype."], "hard_negative": "PD-1 triggering on monocytes reduces IL-10 production by monocytes."}
{"query_id": "904", "query_text": "PDPN promotes efficient motility along stromal surfaces by activating the C-type lectin receptor to rearrange the actin cytoskeleton in dendritic cells.", "negative": "Autophagy declines in aged organisms.", "negatives": ["Autophagy declines in aged organisms.", "Metastatic colorectal cancer treated with a single agent fluoropyrimidines resulted in reduced efficacy and lower quality of life when compared with oxaliplatin-based chemotherapy in elderly patients.", "NF2 (Merlin) causes phosphorylation and subsequent cytoplasmic sequestration of YAP in Drosophila by activating LATS1/2 kinases.", "Incidence of heart failure decreased by 10% in women since 1979.", "Hypothalamic glutamate neurotransmission is crucial to energy balance.", "Cataract and trachoma are the primary cause of blindness in Southern Sudan.", "High dietary calcium intakes are unnecessary for prevention of secondary hyperparathyroidism in subjects with 25(OH)D levels above 75 nmol/liter.", "Mice without IFN-\u03b3 or its receptor are resistant to EAM induced with \u03b1-MyHC/CFA.", "Recurrent mutations occur frequently within CTCF anchor sites adjacent to oncogenes.", "IRG1 has antiviral effects against neurotropic viruses."], "hard_negatives": ["PDPN promotes efficient motility along stromal surfaces by activating the C-type lectin receptor to rearrange the actin cytoskeleton in dendritic cells.", "Ly49Q directs the organization of neutrophil migration to inflammation sites by regulating membrane raft functions.", "ITAM phosphorylation prevents the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).", "Fz/PCP-dependent Pk localizes to the anterior membrane of neuroectoderm cells during zebrafish neuralation", "The binding orientation of the ML-SA1 activator at hTRPML2 is different from the binding orientation of the ML-SA1 activator at hTRPML1.", "NR5A2 is important in development of endometrial tissues.", "PPAR-RXRs can be activated by PPAR ligands.", "DMRT1 is a sex-determining gene that is epigenetically regulated by the MHM region.", "Pleiotropic coupling of GLP-1R to intracellular effectors promotes distinct profiles of cellular signaling.", "Activator-inhibitor pairs are provided dorsally by Admpchordin."], "hard_negative": "PDPN promotes efficient motility along stromal surfaces by activating the C-type lectin receptor to rearrange the actin cytoskeleton in dendritic cells."}
{"query_id": "907", "query_text": "PGE 2 promotes intestinal tumor growth by altering the expression of tumor suppressing and DNA repair genes.", "negative": "N-terminal cleavage increases success identifying transcription start sites.", "negatives": ["N-terminal cleavage increases success identifying transcription start sites.", "Cellular aging closely links to an older appearance.", "N-terminal cleavage increases success identifying transcription start sites.", "LDL cholesterol has no involvement in the development of cardiovascular disease.", "Hematopoietic Stem Cell purification reaches purity rate of up to 50%.", "Bone marrow cells contribute to adult macrophage compartments.", "Varenicline monotherapy is more effective after 12 weeks of treatment compared to combination nicotine replacement therapies with varenicline or bupropion.", "Polymeal nutrition reduces cardiovascular mortality.", "Febrile seizures increase the threshold for development of epilepsy.", "Non-invasive ventilation use should be decreased if there is inadequate response to conventional treatment."], "hard_negatives": ["PGE 2 promotes intestinal tumor growth by altering the expression of tumor suppressing and DNA repair genes.", "Aspirin inhibits the production of PGE2.", "PKG-la plays an essential role in expression of pain hypersensitivity in PGK-la knockout mice.", "Activation of PPM1D suppresses p53 function.", "Up-regulation of the p53 pathway and related molecular events casues cancer resistance and results in a significantly shortened lifespan marked by senescent cells and accelerated organismal aging.", "Normal expression of RUNX1 has tumor-promoting effects.", "p16INK4A accumulation is  linked to an abnormal wound response caused by the microinvasive step of advanced Oral Potentially Malignant Lesions (OPMLs).", "Pseudogene PTENP1 regulates the expression of PTEN by functioning as an miRNA decoy.", "CX3CR1 on the Th2 cells promotes airway inflammation.", "NR5A2 is important in development of endometrial tissues."], "hard_negative": "PGE 2 promotes intestinal tumor growth by altering the expression of tumor suppressing and DNA repair genes."}
{"query_id": "911", "query_text": "PKG-la plays an essential role in expression of pain hypersensitivity in PGK-la knockout mice.", "negative": "Chenodeosycholic acid treatment reduces whole-body energy expenditure.", "negatives": ["Chenodeosycholic acid treatment reduces whole-body energy expenditure.", "Statins increase blood cholesterol.", "Deamination of cytidine to uridine on the minus strand of viral DNA results in catastrophic G-to-A mutations in the viral genome.", "CRP is not predictive of postoperative mortality following Coronary Artery Bypass Graft (CABG) surgery.", "The extracellular domain of TMEM27 is cleaved in human beta cells.", "0-dimensional biomaterials show inductive properties.", "Localization of PIN1 in the roots of Arabidopsis does not require VPS9a", "New drugs for tuberculosis often do not penetrate the necrotic portion of a tuberculosis lesion in high concentrations.", "Normal expression of RUNX1 has tumor-promoting effects.", "IRG1 has antiviral effects against neurotropic viruses."], "hard_negatives": ["PKG-la plays an essential role in expression of pain hypersensitivity in PGK-la knockout mice.", "PGE 2 promotes intestinal tumor growth by altering the expression of tumor suppressing and DNA repair genes.", "Activation of PPM1D suppresses p53 function.", "Aspirin inhibits the production of PGE2.", "TNFAIP3 is a tumor suppressor in glioblastoma.", "p16INK4A accumulation is  linked to an abnormal wound response caused by the microinvasive step of advanced Oral Potentially Malignant Lesions (OPMLs).", "PPAR-RXRs can be activated by PPAR ligands.", "mTORC2 regulates intracellular cysteine levels through xCT inhibition.", "FoxO3a activation in neuronal death is mediated by reactive oxygen species (ROS).", "PPAR-RXRs are inhibited by PPAR ligands."], "hard_negative": "PKG-la plays an essential role in expression of pain hypersensitivity in PGK-la knockout mice."}
{"query_id": "913", "query_text": "PPAR-RXRs are inhibited by PPAR ligands.", "negative": "ALDH1 expression is associated with poorer prognosis in breast cancer.", "negatives": ["ALDH1 expression is associated with poorer prognosis in breast cancer.", "Venules have a larger lumen diameter than arterioles.", "Blocking the interaction between TDP-43 and respiratory complex I proteins ND3 and ND6 leads to increased TDP-43-induced neuronal loss.", "Increased vessel density along with a reduction in fibrosis decreases the efficacy of chemotherapy treatments.", "Chenodeosycholic acid treatment increases whole-body energy expenditure.", "CCL19 is absent within dLNs.", "High levels of copeptin decrease risk of diabetes.", "Diabetic patients with acute coronary syndrome experience increased short-term and long-term risk for bleeding events.", "Febrile seizures increase the threshold for development of epilepsy.", "The center of the granuloma in an immune cell induces a pro-inflammatory immune response."], "hard_negatives": ["PPAR-RXRs are inhibited by PPAR ligands.", "PPAR-RXRs can be activated by PPAR ligands.", "The PPR MDA5 has two N-terminal CARD domains.", "Activation of PPM1D suppresses p53 function.", "PKG-la plays an essential role in expression of pain hypersensitivity in PGK-la knockout mice.", "The PRR MDA5 has a central DExD/H RNA helices domain.", "Leukemia associated Rho guanine nucleotide-exchange factor represses RhoA in response to SRC activation.", "mTORC2 regulates intracellular cysteine levels through xCT inhibition.", "PDPN promotes efficient motility along stromal surfaces by activating the C-type lectin receptor to rearrange the actin cytoskeleton in dendritic cells.", "The binding orientation of the ML-SA1 activator at hTRPML2 is different from the binding orientation of the ML-SA1 activator at hTRPML1."], "hard_negative": "PPAR-RXRs are inhibited by PPAR ligands."}
{"query_id": "914", "query_text": "PPAR-RXRs can be activated by PPAR ligands.", "negative": "cSMAC formation enhances weak ligand signalling.", "negatives": ["cSMAC formation enhances weak ligand signalling.", "Integrating classroom-based collaborative learning with Web-based collaborative learning leads to subpar class performance", "Fz/PCP-dependent Pk localizes to the anterior membrane of neuroectoderm cells during zebrafish neuralation", "Asymptomatic visual impairment screening in elderly populations does not lead to improved vision.", "Pyridostatin destabilizes the G - quadruplex in the telomeric region.", "Mice without IFN-\u03b3 or its receptor are resistant to EAM induced with \u03b1-MyHC/CFA.", "Chenodeosycholic acid treatment increases whole-body energy expenditure.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have increased risk for dementia.", "Bariatric surgery has a positive impact on mental health.", "Angiotensin converting enzyme inhibitors are associated with increased risk for functional renal insufficiency."], "hard_negatives": ["PPAR-RXRs can be activated by PPAR ligands.", "PPAR-RXRs are inhibited by PPAR ligands.", "The PPR MDA5 has two N-terminal CARD domains.", "PKG-la plays an essential role in expression of pain hypersensitivity in PGK-la knockout mice.", "PDPN promotes efficient motility along stromal surfaces by activating the C-type lectin receptor to rearrange the actin cytoskeleton in dendritic cells.", "Leukemia associated Rho guanine nucleotide-exchange factor represses RhoA in response to SRC activation.", "The PRR MDA5 has a central DExD/H RNA helices domain.", "mTORC2 regulates intracellular cysteine levels through xCT inhibition.", "Pleiotropic coupling of GLP-1R to intracellular effectors promotes distinct profiles of cellular signaling.", "The binding orientation of the ML-SA1 activator at hTRPML2 is different from the binding orientation of the ML-SA1 activator at hTRPML1."], "hard_negative": "PPAR-RXRs can be activated by PPAR ligands."}
{"query_id": "921", "query_text": "Participating in six months of physical activity improves cognitive functioning.", "negative": "Peroxynitrite is required for nitration of TCR/CD8.", "negatives": ["Peroxynitrite is required for nitration of TCR/CD8.", "Homozygous deletion of murine Sbds gene from osterix-expressing mesenchymal stem and progenitor cells (MPCs) prevents oxidative stress.", "Cytosolic proteins bind to iron-responsive elements on mRNAs coding for DMT1. Cytosolic proteins bind to iron-responsive elements on mRNAs coding for proteins involved in iron uptake.", "ITAM phosphorylation prevents the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).", "In mice, P. chabaudi parasites are able to proliferate faster early in infection when inoculated at lower numbers than when inoculated at high numbers.", "Ethanol stress decreases the expression of IBP in bacteria.", "During the primary early antibody response activated B cells migrate toward the inner-and outer paracortical areas where oxysterol accumulation is generated by stromal cells.", "Varenicline monotherapy is more effective after 12 weeks of treatment compared to combination nicotine replacement therapies with varenicline or bupropion.", "IgA plasma cells that are specific for transglutaminase 2 accumulate in the duodenal mucosa on commencement of a gluten-free diet.", "Mutations in G-Beta protein GNB2 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway."], "hard_negatives": ["Participating in six months of physical activity improves cognitive functioning.", "Headaches are not correlated with cognitive impairment.", "Insomnia can be effectively treated with cognitive behavioral therapy.", "Input from  mental and physical health care professionals is effective at decreasing homelessness.", "Auditory entrainment is strengthened when people see congruent visual and auditory information.", "Hypothalamic glutamate neurotransmission is crucial to energy balance.", "Integrating classroom-based collaborative learning with Web-based collaborative learning leads to subpar class performance", "In young and middle-aged adults, current or remote uses of ADHD medications do not increase the risk of serious cardiovascular events.", "Asymptomatic visual impairment screening in elderly populations does not lead to improved vision.", "Obesity decreases life quality."], "hard_negative": "Participating in six months of physical activity improves cognitive functioning."}
{"query_id": "922", "query_text": "Patients in stable partnerships have a faster progression from HIV to AIDS.", "negative": "Cold exposure increases BAT recruitment.", "negatives": ["Cold exposure increases BAT recruitment.", "Primary cervical cancer screening with HPV detection has higher longitudinal sensitivity than conventional cytology to detect cervical intraepithelial neoplasia grade 2.", "Statins decrease blood cholesterol.", "0-dimensional biomaterials show inductive properties.", "Smc5/6 engagment drives the activation of SUMO E3 ligase Mms21 by ATP-dependent remolding.", "Teaching hospitals do not provide better care than non-teaching hospitals.", "Thigh-length graduated compression stockings (GCS) did not reduce deep vein thrombosis in patients admitted to hospital who are immobile because of acute stroke.", "Occupancy of ribosomes by IncRNAs do not make functional peptides.", "The benefits of colchicine were achieved with effective widespread use of secondary prevention strategies such as high-dose statins.", "Monoclonal antibody targeting of N-cadherin inhibits metastasis."], "hard_negatives": ["Patients in stable partnerships have a faster progression from HIV to AIDS.", "Antiretroviral therapy reduces rates of tuberculosis across a broad range of CD4 strata.", "Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have a dramatic impact in reducing malaria transmission.", "Input from  mental and physical health care professionals is effective at decreasing homelessness.", "New drugs for tuberculosis often do not penetrate the necrotic portion of a tuberculosis lesion in high concentrations.", "Teaching hospitals do not provide better care than non-teaching hospitals.", "A total of 1,000 people in the UK are asymptomatic carriers of vCJD infection.", "The availability of safe places to study is not effective at decreasing homelessness.", "Healthcare delivery efficiency in crowded delivery centers is impaired by improving structural, logistical, and interpersonal elements.", "The treatment of cancer patients with co-IR blockade does not cause any adverse autoimmune events."], "hard_negative": "Patients in stable partnerships have a faster progression from HIV to AIDS."}
{"query_id": "936", "query_text": "Peroxynitrite is required for nitration of TCR/CD8.", "negative": "Individuals with low serum vitamin D concentrations have increased risk of multiple sclerosis.", "negatives": ["Individuals with low serum vitamin D concentrations have increased risk of multiple sclerosis.", "Replacement of histone H2A with H2A.Z slows gene activation in yeasts by stabilizing +1 nucleosomes.", "Chronic aerobic exercise alters endothelial function, improving vasodilating mechanisms mediated by NO.", "Arterioles have a larger lumen diameter than venules.", "cSMAC formation enhances weak ligand signalling.", "Arterioles have a larger lumen diameter than venules.", "Tetraspanin-3 is a causative factor in the development of acute myelogenous leukemia", "Proteins synthesized at the growth cone are ubiquitinated at a higher rate than proteins from the cell body.", "Aspirin inhibits the production of PGE2.", "Insulin increases risk of severe kidney failure."], "hard_negatives": ["Peroxynitrite is required for nitration of TCR/CD8.", "NOX2-independent pathways can generate peroxynitrite by reacting with nitrogen intermediates.", "Active H. pylori urease has a polymeric structure that compromises two subunits, UreA and UreB.", "Mercaptopurine is anabolized into the inactive methylmercaptopurine by thiopurine methyltrasnferase (TPMT).", "High levels of CRP reduces the risk of exacerbations in chronic obstructive pulmonary disease (COPD).", "TCR/CD3 microdomains are a required to induce the immunologic synapse to activate T cells.", "Radioiodine treatment of non-toxic multinodular goitre reduces thyroid volume.", "N348I mutations cause resistance to zidovudine (AZT).", "ITAM phosphorylation prevents the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).", "Mice without IFN-\u03b3 or its receptor are resistant to EAM induced with \u03b1-MyHC/CFA."], "hard_negative": "Peroxynitrite is required for nitration of TCR/CD8."}
{"query_id": "956", "query_text": "Pleiotropic coupling of GLP-1R to intracellular effectors promotes distinct profiles of cellular signaling.", "negative": "Gene expression does not vary appreciably across genetically identical cells.", "negatives": ["Gene expression does not vary appreciably across genetically identical cells.", "Homozygous deletion of murine Sbds gene from osterix-expressing mesenchymal stem and progenitor cells (MPCs) prevents oxidative stress.", "Cytosolic proteins bind to iron-responsive elements on mRNAs coding for DMT1. Cytosolic proteins bind to iron-responsive elements on mRNAs coding for proteins involved in iron uptake.", "Antiretroviral therapy reduces rates of tuberculosis across a broad range of CD4 strata.", "CX3CR1 on the Th2 cells suppresses airway inflammation.", "The DdrB protein from Deinococcus radiodurans is an alternative SSB.", "5% of perinatal mortality is due to low birth weight.", "Diabetic patients with acute coronary syndrome experience increased short-term and long-term risk for bleeding events.", "Tumor necrosis factor alpha (TNF-\u03b1) and interleukin-1 (IL-1) are pro-inflammatory cytokines that inhibit IL-6 and IL-10.", "Basophils counteract disease development in patients with systemic lupus erythematosus (SLE)."], "hard_negatives": ["Pleiotropic coupling of GLP-1R to intracellular effectors promotes distinct profiles of cellular signaling.", "Ly49Q directs the organization of neutrophil migration to inflammation sites by regulating membrane raft functions.", "Primary pro-inflammatory cytokines induce secondary pro- and anti-inflammatory mediators.", "PDPN promotes efficient motility along stromal surfaces by activating the C-type lectin receptor to rearrange the actin cytoskeleton in dendritic cells.", "Glycolysis is one of the primary glycometabolic pathways in cells.", "ITAM phosphorylation prevents the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).", "PPAR-RXRs can be activated by PPAR ligands.", "Leukemia associated Rho guanine nucleotide-exchange factor represses RhoA in response to SRC activation.", "Pyridostatin destabilizes the G - quadruplex in the telomeric region.", "Mutations in G-Beta protein GNB2 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway."], "hard_negative": "Pleiotropic coupling of GLP-1R to intracellular effectors promotes distinct profiles of cellular signaling."}
{"query_id": "957", "query_text": "Podocytes are motile and migrate in the presence of injury.", "negative": "Radioiodine treatment of non-toxic multinodular goitre reduces thyroid volume.", "negatives": ["Radioiodine treatment of non-toxic multinodular goitre reduces thyroid volume.", "Commelina yellow mottle virus' (ComYMV) genome consists of 7489 baise pairs.", "Normal expression of RUNX1 has tumor-promoting effects.", "High-sensitivity cardiac troponin T (HSCT-T) dosage may not be diagnostic if the onset of symptoms occurs less than 3 hours before acute myocardial injury (AMI).", "CX3CR1 on the Th2 cells promotes airway inflammation.", "Mutant mice lacking SVCT2 have greatly increased ascorbic acid levels in both brain and adrenals.", "Vitamin D deficiency effects the term of delivery.", "Podocytes are motile and migrate in the presence of injury.", "Antibiotic induced alterations in the gut microbiome reduce resistance against Clostridium difficile", "PPAR-RXRs are inhibited by PPAR ligands."], "hard_negatives": ["Podocytes are motile and migrate in the presence of injury.", "Only a minority of cells survive development after differentiation into stress-resistant spores.", "Venules have a thinner or absent smooth layer compared to arterioles.", "Mitochondria are uninvolved in apoptosis.", "In mice, P. chabaudi parasites are able to proliferate faster early in infection when inoculated at lower numbers than when inoculated at high numbers.", "Arterioles have a larger lumen diameter than venules.", "The center of the granuloma in an immune cell induces a pro-inflammatory immune response.", "Venules have a larger lumen diameter than arterioles.", "Assembly of invadopodia is triggered by focal generation of phosphatidylinositol-3,4-biphosphate and the activation of the nonreceptor tyrosine kinase Src.", "Proteins synthesized at the growth cone are ubiquitinated at a higher rate than proteins from the cell body."], "hard_negative": "Podocytes are motile and migrate in the presence of injury."}
{"query_id": "960", "query_text": "Polymeal nutrition reduces cardiovascular mortality.", "negative": "Integrating classroom-based collaborative learning with Web-based collaborative learning leads to subpar class performance", "negatives": ["Integrating classroom-based collaborative learning with Web-based collaborative learning leads to subpar class performance", "CX3CR1 on the Th2 cells promotes T cell survival", "Febrile seizures increase the threshold for development of epilepsy.", "N-terminal cleavage increases success identifying transcription start sites.", "Autologous transplantation of mesenchymal stem cells causes fewer opportunistic infections than induction therapy with anti-interleukin-2 receptor antibodies.", "Dexamethasone decreases risk of postoperative bleeding.", "Macrolides have no protective effect against myocardial infarction.", "The one-child policy has been successful in lowering population growth.", "T regulatory cells (tTregs) lacking \u03b1v\u03b28 are more adept at suppressing pathogenic T-cell responses during active inflammation.", "5% of perinatal mortality is due to low birth weight."], "hard_negatives": ["Polymeal nutrition reduces cardiovascular mortality.", "LDL cholesterol has no involvement in the development of cardiovascular disease.", "Obesity is determined solely by environmental factors.", "Macropinocytosis contributes to a cell's supply of amino acids via the intracellular uptake of protein.", "Macrolides protect against myocardial infarction.", "Suboptimal nutrition is not predictive of chronic disease", "Healthcare delivery efficiency in crowded delivery centers is impaired by improving structural, logistical, and interpersonal elements.", "Input from  mental and physical health care professionals is effective at decreasing homelessness.", "Epidemiological disease burden from noncommunicable diseases is more prevalent in low economic settings.", "Flexible molecules experience greater steric hindrance in the tumor microenviroment than rigid molecules."], "hard_negative": "Polymeal nutrition reduces cardiovascular mortality."}
{"query_id": "967", "query_text": "Pretreatment with the Arp2/3 inhibitor CK-666 affects lamelliopodia formation.", "negative": "Therapeutic use of the drug Dapsone to treat pyoderma gangrenous is based on anecdotal evidence.", "negatives": ["Therapeutic use of the drug Dapsone to treat pyoderma gangrenous is based on anecdotal evidence.", "Anthrax spores can be disposed of easily after they are dispersed.", "Thigh-length graduated compression stockings (GCS) did not reduce deep vein thrombosis in patients admitted to hospital who are immobile because of acute stroke.", "PDPN promotes efficient motility along stromal surfaces by activating the C-type lectin receptor to rearrange the actin cytoskeleton in dendritic cells.", "Carriers of the alcohol aldehyde dehydrogenase deficiency mutation drink less that non-carries.", "Upregulation of mosGCTL-1 is induced upon infection with West Nile virus.", "Basophils counteract disease development in patients with systemic lupus erythematosus (SLE).", "Cell autonomous sex determination in somatic cells occurs in Passeriformes.", "Teaching hospitals do not provide better care than non-teaching hospitals.", "Fz/PCP-dependent Pk localizes to the anterior membrane of notochord cells during zebrafish neuralation."], "hard_negatives": ["Pretreatment with the Arp2/3 inhibitor CK-666 affects lamelliopodia formation.", "p16INK4A accumulation is  linked to an abnormal wound response caused by the microinvasive step of advanced Oral Potentially Malignant Lesions (OPMLs).", "Blocking the interaction between TDP-43 and respiratory complex I proteins ND3 and ND6 leads to increased TDP-43-induced neuronal loss.", "Activation of PPM1D suppresses p53 function.", "mTORC2 regulates intracellular cysteine levels through xCT inhibition.", "N348I mutations cause resistance to zidovudine (AZT).", "Assembly of invadopodia is triggered by focal generation of phosphatidylinositol-3,4-biphosphate and the activation of the nonreceptor tyrosine kinase Src.", "Increased vessel density along with a reduction in fibrosis decreases the efficacy of chemotherapy treatments.", "Combining phosphatidylinositide 3-kinase and MEK 1/2 inhibitors is effective at treating KRAS mutant tumors.", "High dietary calcium intakes are unnecessary for prevention of secondary hyperparathyroidism in subjects with 25(OH)D levels above 75 nmol/liter."], "hard_negative": "Pretreatment with the Arp2/3 inhibitor CK-666 affects lamelliopodia formation."}
{"query_id": "971", "query_text": "Primary cervical cancer screening with HPV detection has higher longitudinal sensitivity than conventional cytology to detect cervical intraepithelial neoplasia grade 2.", "negative": "Inositol lipid 3-phosphatase PTEN converts Ptdlns(3,4)P 2 into phosphatidylinositol 4-phosphate.", "negatives": ["Inositol lipid 3-phosphatase PTEN converts Ptdlns(3,4)P 2 into phosphatidylinositol 4-phosphate.", "Deletion of \u03b1v\u03b28 does not result in a spontaneous inflammatory phenotype.", "The deregulated and prolonged activation of monocytes has deleterious effects in inflammatory diseases.", "Lymphadenopathy is observed in knockin mouse lacking the SHP-2 MAPK pathway.", "Localization of PIN1 in the roots of Arabidopsis does not require VPS9a", "Mice that lack Interferon-\u03b3 or its receptor exhibit high resistance to experimental autoimmune myocarditis.", "S-nitrosylated GAPDH physiologically transnitrosylates histone deacetylases.", "PKG-la plays an essential role in expression of pain hypersensitivity in PGK-la knockout mice.", "Carriers of the alcohol aldehyde dehydrogenase deficiency mutation drink less that non-carries.", "Mitochondria are uninvolved in apoptosis."], "hard_negatives": ["Primary cervical cancer screening with HPV detection has higher longitudinal sensitivity than conventional cytology to detect cervical intraepithelial neoplasia grade 2.", "Incidence rates of cervical cancer have increased due to nationwide screening programs based primarily on cytology to detect uterine cervical cancer.", "Incidence rates of cervical cancer have decreased.", "The risk of breast cancer among parous women increases with placental weight of pregnancies, and this association is strongest for premenopausal breast cancer.", "Women with a higher birth weight are more likely to develop breast cancer later in life.", "Breast cancer development is determined exclusively by genetic factors.", "A total of 1,000 people in the UK are asymptomatic carriers of vCJD infection.", "CHEK2 is not associated with breast cancer.", "Birth-weight is positively associated with breast cancer.", "CRP is not predictive of postoperative mortality following Coronary Artery Bypass Graft (CABG) surgery."], "hard_negative": "Primary cervical cancer screening with HPV detection has higher longitudinal sensitivity than conventional cytology to detect cervical intraepithelial neoplasia grade 2."}
{"query_id": "975", "query_text": "Primary pro-inflammatory cytokines induce secondary pro- and anti-inflammatory mediators.", "negative": "Increased vessel density along with a reduction in fibrosis decreases the efficacy of chemotherapy treatments.", "negatives": ["Increased vessel density along with a reduction in fibrosis decreases the efficacy of chemotherapy treatments.", "Free histones are degraded by a Rad53-dependent mechanism once DNA has been replicated.", "In young and middle-aged adults, current or remote uses of ADHD medications do not increase the risk of serious cardiovascular events.", "Articles published in open access format are less likely to be cited than traditional journals.", "The combination of H3K4me3 and H3K79me2 is found in quiescent hair follicle stem cells.", "Varenicline monotherapy is more effective after 12 weeks of treatment compared to combination nicotine replacement therapies with varenicline or bupropion.", "Obesity decreases life quality.", "Modifying the epigenome in the brain affects the normal human aging process by affecting certain genes related to neurogenesis.", "Fz/PCP-dependent Pk localizes to the anterior membrane of neuroectoderm cells during zebrafish neuralation", "Albendazole is used to treat lymphatic filariasis."], "hard_negatives": ["Primary pro-inflammatory cytokines induce secondary pro- and anti-inflammatory mediators.", "Tumor necrosis factor alpha (TNF-\u03b1) and interleukin-1 (IL-1) are pro-inflammatory cytokines that inhibit IL-6 and IL-10.", "Immune responses result in the development of inflammatory Th17 cells and anti-inflammatory iTregs.", "Epigenetic modulating agents (EMAs) modulate antitumor immune response in a cancer model system.", "Enhanced early production of inflammatory chemokines improves viral control in the lung.", "Pleiotropic coupling of GLP-1R to intracellular effectors promotes distinct profiles of cellular signaling.", "Activator-inhibitor pairs are provided dorsally by Admpchordin.", "Crosstalk between dendritic cells (DCs) and innate lymphoid cells (ILCs) is important in the regulation of intestinal homeostasis.", "Mice that lack Interferon-\u03b3 or its receptor exhibit high resistance to experimental autoimmune myocarditis.", "T regulatory cells (tTregs) lacking \u03b1v\u03b28 are more adept at suppressing pathogenic T-cell responses during active inflammation."], "hard_negative": "Primary pro-inflammatory cytokines induce secondary pro- and anti-inflammatory mediators."}
{"query_id": "982", "query_text": "Proteins synthesized at the growth cone are ubiquitinated at a higher rate than proteins from the cell body.", "negative": "Autologous transplantation of mesenchymal stem cells causes a higher rate of opportunistic infections than induction therapy with anti-interleukin-2 receptor antibodies.", "negatives": ["Autologous transplantation of mesenchymal stem cells causes a higher rate of opportunistic infections than induction therapy with anti-interleukin-2 receptor antibodies.", "Exposure to fine particulate air pollution is relate to anxiety prevalence.", "Antiretroviral therapy reduces rates of tuberculosis across a broad range of CD4 strata.", "Nanoparticles can be targeted against specific cell types by incorporating aptamers into lipid nanoparticles.", "Articles published in open access format are less likely to be cited than traditional journals.", "ITAM phosphorylation prevents the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).", "Dexamethasone decreases risk of postoperative bleeding.", "High levels of copeptin decrease risk of diabetes.", "Functional consequences of genomic alterations due to Myelodysplastic syndrome (MDS) are poorly understood due to the lack of an animal model.", "Glycolysis is one of the primary glycometabolic pathways in cells."], "hard_negatives": ["Proteins synthesized at the growth cone are ubiquitinated at a higher rate than proteins from the cell body.", "Only a minority of cells survive development after differentiation into stress-resistant spores.", "Nanoparticles can be targeted against specific cell types by incorporating aptamers into lipid nanoparticles.", "0-dimensional biomaterials show inductive properties.", "Glycolysis is one of the primary glycometabolic pathways in cells.", "Mitochondria are uninvolved in apoptosis.", "Podocytes are motile and migrate in the presence of injury.", "Macropinocytosis contributes to a cell's supply of amino acids via the intracellular uptake of protein.", "The center of the granuloma in an immune cell induces a pro-inflammatory immune response.", "Flexible molecules experience greater steric hindrance in the tumor microenviroment than rigid molecules."], "hard_negative": "Proteins synthesized at the growth cone are ubiquitinated at a higher rate than proteins from the cell body."}
{"query_id": "985", "query_text": "Pseudogene PTENP1 regulates the expression of PTEN by functioning as an miRNA decoy.", "negative": "Only a minority of cells survive development after differentiation into stress-resistant spores.", "negatives": ["Only a minority of cells survive development after differentiation into stress-resistant spores.", "N348I mutations cause resistance to zidovudine (AZT).", "Low expression of miR7a exerts a biological function in testis.", "Diabetic patients with acute coronary syndrome experience increased short-term and long-term risk for bleeding events.", "Leukemia associated Rho guanine nucleotide-exchange factor represses RhoA in response to SRC activation.", "MicroRNA is involved in the regulation of Neural Stem Cell (NSC) differentiation and proliferation dynamic homeostasis", "TCR/CD3 microdomains are a required to induce the immunologic synapse to activate T cells.", "Deamination of cytidine to uridine on the minus strand of viral DNA results in catastrophic G-to-A mutations in the viral genome.", "The YAP1 and TEAD complex tanslocates into the nucleus where it interacts with transcription factors and DNA-binding proteins that modulate target gene transcription.", "Ly6C hi monocytes have a lower inflammatory capacity compared to their Ly6C lo counterparts."], "hard_negatives": ["Pseudogene PTENP1 regulates the expression of PTEN by functioning as an miRNA decoy.", "Inositol lipid 3-phosphatase PTEN converts Ptdlns(3,4)P 2 into phosphatidylinositol 4-phosphate.", "Low expression of miR7a does represses target genes and exerts a biological function in ovaries.", "Low expression of miR7a exerts a biological function in testis.", "TNFAIP3 is a tumor suppressor in glioblastoma.", "IFIT1 restricts viral replication by sequestrating mis-capped viral RNAs.", "Activation of PPM1D suppresses p53 function.", "The extracellular domain of TMEM27 is cleaved in human beta cells.", "ADAR1 binds to Dicer to cleave pre-miRNA.", "Up-regulation of the p53 pathway and related molecular events casues cancer resistance and results in a significantly shortened lifespan marked by senescent cells and accelerated organismal aging."], "hard_negative": "Pseudogene PTENP1 regulates the expression of PTEN by functioning as an miRNA decoy."}
{"query_id": "993", "query_text": "Pyridostatin destabilizes the G - quadruplex in the telomeric region.", "negative": "N348I mutations cause resistance to zidovudine (AZT).", "negatives": ["N348I mutations cause resistance to zidovudine (AZT).", "Chenodeosycholic acid treatment increases whole-body energy expenditure.", "Pretreatment with the Arp2/3 inhibitor CK-666 affects lamelliopodia formation.", "Deleting Raptor reduces G-CSF levels.", "Many proteins in human cells can be post-translationally modified at lysine residues via acetylation.", "Antibiotic induced alterations in the gut microbiome reduce resistance against Clostridium difficile", "T regulatory cells (tTregs) lacking \u03b1v\u03b28 are more adept at suppressing pathogenic T-cell responses during active inflammation.", "UCB T cells maintain high TCR diversity after transplantation.", "A deficiency of vitamin B12 increases blood levels of homocysteine.", "Crossover hot spots are not found within gene promoters in Saccharomyces cerevisiae."], "hard_negatives": ["Pyridostatin destabilizes the G - quadruplex in the telomeric region.", "The arm density of TatAd complexes is due to structural rearrangements within Class1 TatAd complexes such as the 'charge zipper mechanism'.", "Mutations in G-Beta protein GNB2 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.", "The sliding activity of kinesin-8 protein Kip3 promotes bipolar spindle assembly.", "S-nitrosylated GAPDH physiologically transnitrosylates histone deacetylases.", "IgA plasma cells that are specific for transglutaminase 2 accumulate in the duodenal mucosa on commencement of a gluten-free diet.", "PDPN promotes efficient motility along stromal surfaces by activating the C-type lectin receptor to rearrange the actin cytoskeleton in dendritic cells.", "mTORC2 regulates intracellular cysteine levels through xCT inhibition.", "Pleiotropic coupling of GLP-1R to intracellular effectors promotes distinct profiles of cellular signaling.", "NOX2-independent pathways can generate peroxynitrite by reacting with nitrogen intermediates."], "hard_negative": "Pyridostatin destabilizes the G - quadruplex in the telomeric region."}
{"query_id": "1012", "query_text": "Radioiodine treatment of non-toxic multinodular goitre reduces thyroid volume.", "negative": "Mice defective for deoxyribonucleic acid (DNA) polymerase I (polI) reveal increased sensitivity to ionizing radiation (IR).", "negatives": ["Mice defective for deoxyribonucleic acid (DNA) polymerase I (polI) reveal increased sensitivity to ionizing radiation (IR).", "The sliding activity of kinesin-8 protein Kip3 promotes bipolar spindle assembly.", "The sliding activity of kinesin-8 protein Kip3 promotes bipolar spindle assembly.", "The ureABIEFGH gene cluster encodes urease maturation proteins : UreD/UreH, UreE, UreF, and UreG.", "APOE4 expression in iPSC-derived neurons increases AlphaBeta production and tau phosphorylation causing GABA neuron degeneration.", "Synaptic activity enhances local release of brain derived neurotrophic factor from postsynaptic dendrites.", "Polymeal nutrition reduces cardiovascular mortality.", "Low expression of miR7a does represses target genes and exerts a biological function in ovaries.", "In transgenic mice harboring green florescent protein under the control of the Sox2 promoter, less than ten percent of the cells with green florescent colocalize with cell proliferation markers.", "Incidence rates of cervical cancer have increased due to nationwide screening programs based primarily on cytology to detect uterine cervical cancer."], "hard_negatives": ["Radioiodine treatment of non-toxic multinodular goitre reduces thyroid volume.", "Metastatic colorectal cancer treated with a single agent fluoropyrimidines resulted in reduced efficacy and lower quality of life when compared with oxaliplatin-based chemotherapy in elderly patients.", "Peroxynitrite is required for nitration of TCR/CD8.", "Increased vessel density along with a reduction in fibrosis decreases the efficacy of chemotherapy treatments.", "The treatment of cancer patients with co-IR blockade precipitates adverse autoimmune events.", "High-sensitivity cardiac troponin T (HSCT-T) dosage may not be diagnostic if the onset of symptoms occurs less than 3 hours before acute myocardial injury (AMI).", "The treatment of cancer patients with co-IR blockade does not cause any adverse autoimmune events.", "Dexamethasone decreases risk of postoperative bleeding.", "Angiotensin converting enzyme inhibitors are associated with increased risk for functional renal insufficiency.", "The relationship between a breast cancer patient's capacity to metabolize tamoxifen and treatment outcome is dependent on the patient's genetic make-up."], "hard_negative": "Radioiodine treatment of non-toxic multinodular goitre reduces thyroid volume."}
{"query_id": "1014", "query_text": "Rapamycin decreases the concentration of triacylglycerols in fruit flies.", "negative": "T regulatory cells (tTregs) lacking \u03b1v\u03b28 are more adept at suppressing pathogenic T-cell responses during active inflammation.", "negatives": ["T regulatory cells (tTregs) lacking \u03b1v\u03b28 are more adept at suppressing pathogenic T-cell responses during active inflammation.", "The PRR MDA5 has a central DExD/H RNA helices domain.", "ALDH1 expression is associated with poorer prognosis in breast cancer.", "Hypothalamic glutamate neurotransmission is crucial to energy balance.", "Low nucleosome occupancy correlates with low methylation levels across species.", "Cytochrome c is released from the mitochondrial intermembrane space to cytosol during apoptosis.", "In mouse models, the loss of CSF1R facilitates MOZ-TIF2-induced leuekmogenesis.", "Tetraspanin-3 is a causative factor in the development of acute myelogenous leukemia", "Lymphadenopathy is observed in knockin mouse lacking the SHP-2 MAPK pathway.", "Aspirin inhibits the production of PGE2."], "hard_negatives": ["Rapamycin decreases the concentration of triacylglycerols in fruit flies.", "Mercaptopurine is anabolized into the inactive methylmercaptopurine by thiopurine methyltrasnferase (TPMT).", "Ethanol stress decreases the expression of IBP in bacteria.", "Omnivores produce less trimethylamine N-oxide from dietary I-carnitine than vegetarians.", "Aspirin inhibits the production of PGE2.", "Sildenafil improves erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.", "APOE4 expression in iPSC-derived neurons increases AlphaBeta production and tau phosphorylation, delaying GABA neuron degeneration.", "APOE4 expression in iPSC-derived neurons increases AlphaBeta production and tau phosphorylation causing GABA neuron degeneration.", "NF2 (Merlin) causes phosphorylation and subsequent cytoplasmic sequestration of YAP in Drosophila by activating LATS1/2 kinases.", "Statins decrease blood cholesterol."], "hard_negative": "Rapamycin decreases the concentration of triacylglycerols in fruit flies."}
{"query_id": "1019", "query_text": "Rapid phosphotransfer rates govern fidelity in two component systems", "negative": "The PRR MDA5 has a central DExD/H RNA helices domain.", "negatives": ["The PRR MDA5 has a central DExD/H RNA helices domain.", "Varenicline monotherapy is more effective after 12 weeks of treatment compared to combination nicotine replacement therapies with varenicline or bupropion.", "Hypertension is frequently observed in type 1 diabetes patients.", "Monoclonal antibody targeting of N-cadherin inhibits metastasis.", "Immune responses result in the development of inflammatory Th17 cells and anti-inflammatory iTregs.", "T regulatory cells (tTregs) lacking \u03b1v\u03b28 are more adept at suppressing pathogenic T-cell responses during active inflammation.", "mTORC2 regulates intracellular cysteine levels through xCT inhibition.", "Alizarin forms hydrogen bonds with residues involved in PGAM1 substrate binding.", "Low expression of miR7a does represses target genes and exerts a biological function in ovaries.", "Aspirin inhibits the production of PGE2."], "hard_negatives": ["Rapid phosphotransfer rates govern fidelity in two component systems", "0-dimensional biomaterials show inductive properties.", "Integrating classroom-based collaborative learning with Web-based collaborative learning leads to subpar class performance", "Pleiotropic coupling of GLP-1R to intracellular effectors promotes distinct profiles of cellular signaling.", "The arm density of TatAd complexes is due to structural rearrangements within Class1 TatAd complexes such as the 'charge zipper mechanism'.", "Low nucleosome occupancy correlates with low methylation levels across species.", "Flexible molecules experience greater steric hindrance in the tumor microenviroment than rigid molecules.", "Gene expression does not vary appreciably across genetically identical cells.", "Peroxynitrite is required for nitration of TCR/CD8.", "Replacement of histone H2A with H2A.Z slows gene activation in yeasts by stabilizing +1 nucleosomes."], "hard_negative": "Rapid phosphotransfer rates govern fidelity in two component systems"}
{"query_id": "1020", "query_text": "Rapid up-regulation and higher basal expression of interferon-induced genes increase survival of granule cell neurons that are infected by West Nile virus.", "negative": "PKG-la plays an essential role in expression of pain hypersensitivity in PGK-la knockout mice.", "negatives": ["PKG-la plays an essential role in expression of pain hypersensitivity in PGK-la knockout mice.", "T regulatory cells (tTregs) lacking \u03b1v\u03b28 are more adept at suppressing pathogenic T-cell responses during active inflammation.", "Cell autonomous sex determination in somatic cells occurs in Passeriformes.", "NR5A2 is important in development of endometrial tissues.", "Histone demethylase recruitment and a transient decrease in histone methylation is necessary for ligand-dependent induction of transcription by nuclear receptors.", "Varenicline monotherapy is more effective after 12 weeks of treatment compared to combination nicotine replacement therapies with varenicline or bupropion.", "1/2000 in UK have abnormal PrP positivity.", "Mice defective for deoxyribonucleic acid (DNA) polymerase I (polI) reveal increased sensitivity to ionizing radiation (IR).", "The combination of H3K4me3 and H3K79me2 is found in quiescent hair follicle stem cells.", "Ubiquitin ligase UBC13 generates a K63-linked polyubiquitin moiety at PCNA K164."], "hard_negatives": ["Rapid up-regulation and higher basal expression of interferon-induced genes increase survival of granule cell neurons that are infected by West Nile virus.", "Rapid up-regulation and higher basal expression of interferon-induced genes reduce survival of granule cell neurons that are infected by West Nile virus.", "Upregulation of mosGCTL-1 is induced upon infection with West Nile virus.", "Mice that lack Interferon-\u03b3 or its receptor exhibit high resistance to experimental autoimmune myocarditis.", "Transplanted human glial progenitor cells are incapable of forming a neural network with host animals' neurons.", "Infection of human T-cell lymphotropic virus type 1 is most frequent in individuals of African origin.", "Crosstalk between dendritic cells (DCs) and innate lymphoid cells (ILCs) is important in the regulation of intestinal homeostasis.", "Hypothalamic glutamate neurotransmission is crucial to energy balance.", "Enhanced early production of inflammatory chemokines improves viral control in the lung.", "IRG1 has antiviral effects against neurotropic viruses."], "hard_negative": "Rapid up-regulation and higher basal expression of interferon-induced genes increase survival of granule cell neurons that are infected by West Nile virus."}
{"query_id": "1021", "query_text": "Rapid up-regulation and higher basal expression of interferon-induced genes reduce survival of granule cell neurons that are infected by West Nile virus.", "negative": "Chronic aerobic exercise alters endothelial function, improving vasodilating mechanisms mediated by NO.", "negatives": ["Chronic aerobic exercise alters endothelial function, improving vasodilating mechanisms mediated by NO.", "Cell autonomous sex determination in somatic cells does not occur in Galliformes.", "Aspirin inhibits the production of PGE2.", "Lymphadenopathy is observed in knockin mouse lacking the SHP-2 MAPK pathway.", "Healthcare delivery efficiency in crowded delivery centers is impaired by improving structural, logistical, and interpersonal elements.", "IRG1 has antiviral effects against neurotropic viruses.", "Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have a dramatic impact in reducing malaria transmission.", "Therapeutic use of the drug Dapsone to treat pyoderma gangrenous is based on anecdotal evidence.", "Subcutaneous fat depots undergo extensive browning processes after cold exposure.", "Ivermectin is used to treat lymphatic filariasis."], "hard_negatives": ["Rapid up-regulation and higher basal expression of interferon-induced genes reduce survival of granule cell neurons that are infected by West Nile virus.", "Rapid up-regulation and higher basal expression of interferon-induced genes increase survival of granule cell neurons that are infected by West Nile virus.", "Upregulation of mosGCTL-1 is induced upon infection with West Nile virus.", "Mice that lack Interferon-\u03b3 or its receptor exhibit high resistance to experimental autoimmune myocarditis.", "Infection of human T-cell lymphotropic virus type 1 is most frequent in individuals of African origin.", "Transplanted human glial progenitor cells are incapable of forming a neural network with host animals' neurons.", "Crosstalk between dendritic cells (DCs) and innate lymphoid cells (ILCs) is important in the regulation of intestinal homeostasis.", "IRG1 has antiviral effects against neurotropic viruses.", "Golli-deficient T-cells prefer to differentiate into an anergic phenotype in the adaptive immune response when there are increased levels of Ca2+ in the cytosol.", "Enhanced early production of inflammatory chemokines improves viral control in the lung."], "hard_negative": "Rapid up-regulation and higher basal expression of interferon-induced genes reduce survival of granule cell neurons that are infected by West Nile virus."}
{"query_id": "1024", "query_text": "Recurrent mutations occur frequently within CTCF anchor sites adjacent to oncogenes.", "negative": "Metastatic colorectal cancer treated with a single agent fluoropyrimidines resulted in reduced efficacy and lower quality of life when compared with oxaliplatin-based chemotherapy in elderly patients.", "negatives": ["Metastatic colorectal cancer treated with a single agent fluoropyrimidines resulted in reduced efficacy and lower quality of life when compared with oxaliplatin-based chemotherapy in elderly patients.", "Epigenetic modulating agents (EMAs) modulate antitumor immune response in a cancer model system.", "The risk of breast cancer among parous women increases with placental weight of pregnancies, and this association is strongest for premenopausal breast cancer.", "Golli-deficient T-cells prefer to differentiate into an anergic phenotype in the adaptive immune response when there are increased levels of Ca2+ in the cytosol.", "Obesity is determined solely by environmental factors.", "Obesity decreases life quality.", "Articles published in open access format are more likely to be cited than traditional journals.", "S-nitrosylated GAPDH physiologically transnitrosylates histone deacetylases.", "Free histones are degraded by a Rad53-dependent mechanism once DNA has been replicated.", "Mitochondria are uninvolved in apoptosis."], "hard_negatives": ["Recurrent mutations occur frequently within CTCF anchor sites adjacent to oncogenes.", "The PPR MDA5 has two N-terminal CARD domains.", "Occupancy of ribosomes by IncRNAs do not make functional peptides.", "Ribosomopathies have a low degree of cell and tissue specific pathology.", "Occupancy of ribosomes by IncRNAs mirror 5 0-UTRs", "Crossover hot spots are not found within gene promoters in Saccharomyces cerevisiae.", "In mouse models, the loss of CSF1R facilitates MOZ-TIF2-induced leuekmogenesis.", "CCL19 is absent within dLNs.", "The repair of Cas9-induced double strand breaks in human DNA is error-prone.", "Functional consequences of genomic alterations due to Myelodysplastic syndrome (MDS) are poorly understood due to the lack of an animal model."], "hard_negative": "Recurrent mutations occur frequently within CTCF anchor sites adjacent to oncogenes."}
{"query_id": "1029", "query_text": "Reduced responsiveness to interleukin-2 in regulatory T cells is associated with greater resistance to autoimmune diseases such as Type 1 Diabetes.", "negative": "Mutant mice lacking SVCT2 have greatly increased ascorbic acid levels in both brain and adrenals.", "negatives": ["Mutant mice lacking SVCT2 have greatly increased ascorbic acid levels in both brain and adrenals.", "Normal expression of RUNX1 has tumor-promoting effects.", "De novo assembly of sequence data has more specific contigs than unassembled sequence data.", "The benefits of colchicine were achieved with effective widespread use of secondary prevention strategies such as high-dose statins.", "ADAR1 binds to Dicer to cleave pre-miRNA.", "Taking 400mg of \u03b1-tocopheryl acetate helps to prevent prostate cancer.", "Integrating classroom-based collaborative learning with Web-based collaborative learning leads to subpar class performance", "Arginine 90 in p150n is important for interaction with EB1.", "Infection of human T-cell lymphotropic virus type 1 is most frequent in individuals of African origin.", "During the primary early antibody response activated B cells migrate toward the inner-and outer paracortical areas where oxysterol accumulation is generated by stromal cells."], "hard_negatives": ["Reduced responsiveness to interleukin-2 in regulatory T cells is associated with greater resistance to autoimmune diseases such as Type 1 Diabetes.", "T regulatory cells (tTregs) lacking \u03b1v\u03b28 are more adept at suppressing pathogenic T-cell responses during active inflammation.", "TCR/CD3 microdomains are a required to induce the immunologic synapse to activate T cells.", "CX3CR1 on the Th2 cells impairs T cell survival", "CX3CR1 on the Th2 cells promotes T cell survival", "Mice that lack Interferon-\u03b3 or its receptor exhibit high resistance to experimental autoimmune myocarditis.", "Golli-deficient T-cells prefer to differentiate into an anergic phenotype in the adaptive immune response when there are increased levels of Ca2+ in the cytosol.", "Crosstalk between dendritic cells (DCs) and innate lymphoid cells (ILCs) is important in the regulation of intestinal homeostasis.", "Tumor necrosis factor alpha (TNF-\u03b1) and interleukin-1 (IL-1) are pro-inflammatory cytokines that inhibit IL-6 and IL-10.", "Blocking the interaction between TDP-43 and respiratory complex I proteins ND3 and ND6 leads to increased TDP-43-induced neuronal loss."], "hard_negative": "Reduced responsiveness to interleukin-2 in regulatory T cells is associated with greater resistance to autoimmune diseases such as Type 1 Diabetes."}
{"query_id": "1041", "query_text": "Replacement of histone H2A with H2A.Z slows gene activation in yeasts by stabilizing +1 nucleosomes.", "negative": "Healthcare delivery efficiency in crowded delivery centers is impaired by improving structural, logistical, and interpersonal elements.", "negatives": ["Healthcare delivery efficiency in crowded delivery centers is impaired by improving structural, logistical, and interpersonal elements.", "Histone demethylase recruitment and a transient decrease in histone methylation is necessary for ligand-dependent induction of transcription by nuclear receptors.", "NF2 (Merlin) causes phosphorylation and subsequent cytoplasmic sequestration of YAP in Drosophila by activating LATS1/2 kinases.", "aPKCz causes tumour enhancement by affecting glutamine metabolism.", "Articles published in open access format are less likely to be cited than traditional journals.", "PPAR-RXRs are inhibited by PPAR ligands.", "Ivermectin is used to treat lymphatic filariasis.", "PKG-la plays an essential role in expression of pain hypersensitivity in PGK-la knockout mice.", "Normal expression of RUNX1 has tumor-promoting effects.", "The US health care system can save up to $750 million if 7% of patients waiting for kidney transplants participate in the optimized national kidney paired donation program."], "hard_negatives": ["Replacement of histone H2A with H2A.Z slows gene activation in yeasts by stabilizing +1 nucleosomes.", "Histone demethylase recruitment and a transient decrease in histone methylation is necessary for ligand-dependent induction of transcription by nuclear receptors.", "S-nitrosylated GAPDH physiologically transnitrosylates histone deacetylases.", "Free histones are degraded by a Rad53-dependent mechanism once DNA has been replicated.", "NF2 (Merlin) causes phosphorylation and subsequent cytoplasmic sequestration of YAP in Drosophila by activating LATS1/2 kinases.", "NF2 (Merlin) prevents phosphorylation and subsequent cytoplasmic sequestration of YAP in Drosophila.", "NOX2-independent pathways can generate peroxynitrite by reacting with nitrogen intermediates.", "HNF4A mutations can cause diabetes in mutant carriers by the age of 14 years", "The ureABIEFGH gene cluster is induced by nickel (II) ion.", "Cytochrome c is released from the mitochondrial intermembrane space to cytosol during apoptosis."], "hard_negative": "Replacement of histone H2A with H2A.Z slows gene activation in yeasts by stabilizing +1 nucleosomes."}
{"query_id": "1049", "query_text": "Ribosomopathies have a low degree of cell and tissue specific pathology.", "negative": "Ly6C hi monocytes have a lower inflammatory capacity than Ly6C lo monocytes.", "negatives": ["Ly6C hi monocytes have a lower inflammatory capacity than Ly6C lo monocytes.", "De novo assembly of sequence data has more specific contigs than unassembled sequence data.", "The benefits of colchicine were achieved with effective widespread use of secondary prevention strategies such as high-dose statins.", "Chronic aerobic exercise alters endothelial function, improving vasodilating mechanisms mediated by NO.", "Cell autonomous sex determination in somatic cells does not occur in Galliformes.", "Rapid up-regulation and higher basal expression of interferon-induced genes increase survival of granule cell neurons that are infected by West Nile virus.", "MicroRNA is involved in the regulation of Neural Stem Cell (NSC) differentiation and proliferation dynamic homeostasis", "Diabetic patients with acute coronary syndrome experience increased short-term and long-term risk for bleeding events.", "Incidence of heart failure decreased by 10% in women since 1979.", "CR is associated with higher methylation age."], "hard_negatives": ["Ribosomopathies have a low degree of cell and tissue specific pathology.", "Occupancy of ribosomes by IncRNAs do not make functional peptides.", "Functional consequences of genomic alterations due to Myelodysplastic syndrome (MDS) are poorly understood due to the lack of an animal model.", "Occupancy of ribosomes by IncRNAs mirror 5 0-UTRs", "Many proteins in human cells can be post-translationally modified at lysine residues via acetylation.", "Macrolides protect against myocardial infarction.", "Mutations in G-Beta protein GNB2 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.", "Free histones are degraded by a Rad53-dependent mechanism once DNA has been replicated.", "Recurrent mutations occur frequently within CTCF anchor sites adjacent to oncogenes.", "Macropinocytosis contributes to a cell's supply of amino acids via the intracellular uptake of protein."], "hard_negative": "Ribosomopathies have a low degree of cell and tissue specific pathology."}
{"query_id": "1062", "query_text": "S-nitrosylated GAPDH physiologically transnitrosylates histone deacetylases.", "negative": "The relationship between a breast cancer patient's capacity to metabolize tamoxifen and treatment outcome is dependent on the patient's genetic make-up.", "negatives": ["The relationship between a breast cancer patient's capacity to metabolize tamoxifen and treatment outcome is dependent on the patient's genetic make-up.", "Podocytes are motile and migrate in the presence of injury.", "Activator-inhibitor pairs are provided dorsally by Admpchordin.", "The treatment of cancer patients with co-IR blockade precipitates adverse autoimmune events.", "Peroxynitrite is required for nitration of TCR/CD8.", "Homozygous deletion of murine Sbds gene from osterix-expressing mesenchymal stem and progenitor cells (MPCs) prevents oxidative stress.", "The PRR MDA5 has a central DExD/H RNA helices domain.", "Carriers of the alcohol aldehyde dehydrogenase deficiency mutation drink less that non-carries.", "Upregulation of mosGCTL-1 is induced upon infection with West Nile virus.", "Activator-inhibitor pairs are provided dorsally by Admpchordin."], "hard_negatives": ["S-nitrosylated GAPDH physiologically transnitrosylates histone deacetylases.", "Histone demethylase recruitment and a transient decrease in histone methylation is necessary for ligand-dependent induction of transcription by nuclear receptors.", "Replacement of histone H2A with H2A.Z slows gene activation in yeasts by stabilizing +1 nucleosomes.", "Mercaptopurine is anabolized into the inactive methylmercaptopurine by thiopurine methyltrasnferase (TPMT).", "Blocking the interaction between TDP-43 and respiratory complex I proteins ND3 and ND6 leads to increased TDP-43-induced neuronal loss.", "Free histones are degraded by a Rad53-dependent mechanism once DNA has been replicated.", "Pyridostatin destabilizes the G - quadruplex in the telomeric region.", "NOX2-independent pathways can generate peroxynitrite by reacting with nitrogen intermediates.", "Active H. pylori urease has a polymeric structure that compromises two subunits, UreA and UreB.", "Ly49Q directs the organization of neutrophil migration to inflammation sites by regulating membrane raft functions."], "hard_negative": "S-nitrosylated GAPDH physiologically transnitrosylates histone deacetylases."}
{"query_id": "1086", "query_text": "Sildenafil improves erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.", "negative": "Upregulation of mosGCTL-1 is induced upon infection with West Nile virus.", "negatives": ["Upregulation of mosGCTL-1 is induced upon infection with West Nile virus.", "Infection of human T-cell lymphotropic virus type 1 is most frequent in individuals of African origin.", "The benefits of colchicine were achieved with effective widespread use of secondary prevention strategies such as high-dose statins.", "Participating in six months of physical activity improves cognitive functioning.", "Angiotensin converting enzyme inhibitors are associated with increased risk for functional renal insufficiency.", "Primary pro-inflammatory cytokines induce secondary pro- and anti-inflammatory mediators.", "Lupus-prone mice infected with curliproducing bacteria have higher autoantibody titers compared to controls.", "The YAP1 and TEAD complex tanslocates into the nucleus where it interacts with transcription factors and DNA-binding proteins that modulate target gene transcription.", "Modifying the epigenome in the brain affects the normal human aging process by affecting certain genes related to neurogenesis.", "The binding orientation of the ML-SA1 activator at hTRPML2 is different from the binding orientation of the ML-SA1 activator at hTRPML1."], "hard_negatives": ["Sildenafil improves erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.", "Dexamethasone decreases risk of postoperative bleeding.", "Varenicline monotherapy is more effective after 12 weeks of treatment compared to combination nicotine replacement therapies with varenicline or bupropion.", "Combination nicotine replacement therapies with varenicline or bupropion lead to significantly higher long-term abstinence rates at 52 weeks than varenicline monotherapy.", "The risk of breast cancer among parous women increases with placental weight of pregnancies, and this association is strongest for premenopausal breast cancer.", "Taking 400mg of \u03b1-tocopheryl acetate helps to prevent prostate cancer.", "The relationship between a breast cancer patient's capacity to metabolize tamoxifen and treatment outcome is dependent on the patient's genetic make-up.", "In young and middle-aged adults, current or remote uses of ADHD medications do not increase the risk of serious cardiovascular events.", "Monoclonal antibody targeting of N-cadherin inhibits metastasis.", "LDL cholesterol has no involvement in the development of cardiovascular disease."], "hard_negative": "Sildenafil improves erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants."}
{"query_id": "1088", "query_text": "Silencing of Bcl2 is important for the maintenance and progression of tumors.", "negative": "Insomnia can be effectively treated with cognitive behavioral therapy.", "negatives": ["Insomnia can be effectively treated with cognitive behavioral therapy.", "Deamination of cytidine to uridine on the minus strand of viral DNA results in catastrophic G-to-A mutations in the viral genome.", "Low expression of miR7a exerts a biological function in testis.", "Input from  mental and physical health care professionals is effective at decreasing homelessness.", "NFAT4 activation requires IP3R-mediated Ca2+ mobilization.", "CR is associated with higher methylation age.", "Localization of PIN1 in the Arabidopsis embryo does not require VPS9a", "Localization of PIN1 in the Arabidopsis embryo does not require VPS9a", "Transferred UCB T cells acquire a memory-like phenotype in recipients.", "CCL19 is absent within dLNs."], "hard_negatives": ["Silencing of Bcl2 is important for the maintenance and progression of tumors.", "Downregulation and mislocalization of Scribble prevents cell transformation and mammary tumorigenesis.", "Increased vessel density along with a reduction in fibrosis decreases the efficacy of chemotherapy treatments.", "The genomic aberrations found in matasteses are very similar to those found in the primary tumor.", "The severity of cardiac involvement in amyloidosis can be described by the degree of transmurality of late gadolinium enhancement in MRI.", "PGE 2 promotes intestinal tumor growth by altering the expression of tumor suppressing and DNA repair genes.", "Up-regulation of the p53 pathway and related molecular events casues cancer resistance and results in a significantly shortened lifespan marked by senescent cells and accelerated organismal aging.", "The deregulated and prolonged activation of monocytes has deleterious effects in inflammatory diseases.", "Mutations in G-Beta protein GNB2 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.", "Flexible molecules experience greater steric hindrance in the tumor microenviroment than rigid molecules."], "hard_negative": "Silencing of Bcl2 is important for the maintenance and progression of tumors."}
{"query_id": "1089", "query_text": "Smc5/6 engagment drives the activation of SUMO E3 ligase Mms21 by ATP-dependent remolding.", "negative": "Fz/PCP-dependent Pk localizes to the anterior membrane of notochord cells during zebrafish neuralation.", "negatives": ["Fz/PCP-dependent Pk localizes to the anterior membrane of notochord cells during zebrafish neuralation.", "NF2 (Merlin) causes phosphorylation and subsequent cytoplasmic sequestration of YAP in Drosophila by activating LATS1/2 kinases.", "Metastatic colorectal cancer treated with a single agent fluoropyrimidines resulted in reduced efficacy and lower quality of life when compared with oxaliplatin-based chemotherapy in elderly patients.", "PKG-la plays an essential role in expression of pain hypersensitivity in PGK-la knockout mice.", "Fz/PCP-dependent Pk localizes to the anterior membrane of notochord cells during zebrafish neuralation.", "Non-invasive ventilation use should be decreased if there is inadequate response to conventional treatment.", "Recurrent mutations occur frequently within CTCF anchor sites adjacent to oncogenes.", "N-terminal cleavage reduces success identifying transcription start sites.", "Mutant mice lacking SVCT2 have greatly increased ascorbic acid levels in both brain and adrenals.", "Insomnia can be effectively treated with cognitive behavioral therapy."], "hard_negatives": ["Smc5/6 engagment drives the activation of SUMO E3 ligase Mms21 by ATP-dependent remolding.", "Ubiquitin ligase UBC13 generates a K63-linked polyubiquitin moiety at PCNA K164.", "The binding orientation of the ML-SA1 activator at hTRPML2 is different from the binding orientation of the ML-SA1 activator at hTRPML1.", "PDPN promotes efficient motility along stromal surfaces by activating the C-type lectin receptor to rearrange the actin cytoskeleton in dendritic cells.", "The sliding activity of kinesin-8 protein Kip3 promotes bipolar spindle assembly.", "Activation of PPM1D suppresses p53 function.", "Replacement of histone H2A with H2A.Z slows gene activation in yeasts by stabilizing +1 nucleosomes.", "The PPR MDA5 has two N-terminal CARD domains.", "Ly49Q directs the organization of neutrophil migration to inflammation sites by regulating membrane raft functions.", "Low expression of miR7a does represses target genes and exerts a biological function in ovaries."], "hard_negative": "Smc5/6 engagment drives the activation of SUMO E3 ligase Mms21 by ATP-dependent remolding."}
{"query_id": "1099", "query_text": "Statins decrease blood cholesterol.", "negative": "Incidence rates of cervical cancer have decreased.", "negatives": ["Incidence rates of cervical cancer have decreased.", "The sliding activity of kinesin-8 protein Kip3 promotes bipolar spindle assembly.", "Downregulation and mislocalization of Scribble prevents cell transformation and mammary tumorigenesis.", "Ivermectin is used to treat onchocerciasis.", "1/2000 in UK have abnormal PrP positivity.", "Individuals with low serum vitamin D concentrations have increased risk of multiple sclerosis.", "The deregulated and prolonged activation of monocytes has deleterious effects in inflammatory diseases.", "Diabetic patients with acute coronary syndrome experience increased short-term and long-term risk for bleeding events.", "Statins decrease blood cholesterol.", "Only a minority of cells survive development after differentiation into stress-resistant spores."], "hard_negatives": ["Statins increase blood cholesterol.", "Statins decrease blood cholesterol.", "LDL cholesterol has no involvement in the development of cardiovascular disease.", "Angiotensin converting enzyme inhibitors are associated with increased risk for functional renal insufficiency.", "A deficiency of vitamin B12 increases blood levels of homocysteine.", "Leuko-increased blood increases infectious complications in red blood cell transfusion.", "High levels of copeptin decrease risk of diabetes.", "Leuko-reduced blood reduces infectious complications in red blood cell transfusion.", "Dexamethasone decreases risk of postoperative bleeding.", "High dietary calcium intakes are unnecessary for prevention of secondary hyperparathyroidism in subjects with 25(OH)D levels above 75 nmol/liter."], "hard_negative": "Statins increase blood cholesterol."}
{"query_id": "1100", "query_text": "Statins increase blood cholesterol.", "negative": "Infection of human T-cell lymphotropic virus type 1 is most frequent in individuals of African origin.", "negatives": ["Infection of human T-cell lymphotropic virus type 1 is most frequent in individuals of African origin.", "The YAP1 and TEAD complex tanslocates into the nucleus where it interacts with transcription factors and DNA-binding proteins that modulate target gene transcription.", "Up-regulation of the p53 pathway and related molecular events casues cancer resistance and results in a significantly shortened lifespan marked by senescent cells and accelerated organismal aging.", "1/2000 in UK have abnormal PrP positivity.", "T regulatory cells (tTregs) lacking \u03b1v\u03b28 are more adept at suppressing pathogenic T-cell responses during active inflammation.", "The PRR MDA5 is a sensor of RNA virus infection.", "Exposure to fine particulate air pollution is relate to anxiety prevalence.", "The combination of H3K4me3 and H3K79me2 is found in quiescent hair follicle stem cells.", "Vitamin D deficiency effects the term of delivery.", "APOE4 expression in iPSC-derived neurons increases AlphaBeta production and tau phosphorylation, delaying GABA neuron degeneration."], "hard_negatives": ["Statins increase blood cholesterol.", "Statins decrease blood cholesterol.", "LDL cholesterol has no involvement in the development of cardiovascular disease.", "A deficiency of vitamin B12 increases blood levels of homocysteine.", "Angiotensin converting enzyme inhibitors are associated with increased risk for functional renal insufficiency.", "Leuko-increased blood increases infectious complications in red blood cell transfusion.", "Leuko-reduced blood reduces infectious complications in red blood cell transfusion.", "Dexamethasone decreases risk of postoperative bleeding.", "High levels of copeptin decrease risk of diabetes.", "Hypothalamic glutamate neurotransmission is crucial to energy balance."], "hard_negative": "Statins increase blood cholesterol."}
{"query_id": "1104", "query_text": "Stroke patients with prior use of direct oral anticoagulants have a lower risk of in-hospital mortality than stroke patients with prior use of warfarin.", "negative": "Peroxynitrite is required for nitration of TCR/CD8.", "negatives": ["Peroxynitrite is required for nitration of TCR/CD8.", "Inositol lipid 3-phosphatase PTEN converts Ptdlns(3,4)P 2 into phosphatidylinositol 4-phosphate.", "S-nitrosylated GAPDH physiologically transnitrosylates histone deacetylases.", "High levels of CRP reduces the risk of exacerbations in chronic obstructive pulmonary disease (COPD).", "Auditory entrainment is strengthened when people see congruent visual and auditory information.", "Arterioles have a larger lumen diameter than venules.", "The composition of myosin-II isoform switches from the polarizable B isoform to the more homogenous A isoform during hematopoietic differentiation.", "Synaptic activity enhances local release of brain derived neurotrophic factor from postsynaptic dendrites.", "Less than 10% of the gabonese children with Schimmelpenning-Feuerstein-Mims syndrome (SFM) had a plasma lactate of more than 5mmol/L.", "The ureABIEFGH gene cluster encodes urease maturation proteins : UreD/UreH, UreE, UreF, and UreG."], "hard_negatives": ["Stroke patients with prior use of direct oral anticoagulants have a lower risk of in-hospital mortality than stroke patients with prior use of warfarin.", "Dexamethasone decreases risk of postoperative bleeding.", "Varenicline monotherapy is more effective after 12 weeks of treatment compared to combination nicotine replacement therapies with varenicline or bupropion.", "Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have a dramatic impact in reducing malaria transmission.", "The treatment of cancer patients with co-IR blockade precipitates adverse autoimmune events.", "In young and middle-aged adults, current or remote uses of ADHD medications do not increase the risk of serious cardiovascular events.", "The treatment of cancer patients with co-IR blockade does not cause any adverse autoimmune events.", "Metastatic colorectal cancer treated with a single agent fluoropyrimidines resulted in reduced efficacy and lower quality of life when compared with oxaliplatin-based chemotherapy in elderly patients.", "The relationship between a breast cancer patient's capacity to metabolize tamoxifen and treatment outcome is dependent on the patient's genetic make-up.", "Antiretroviral therapy reduces rates of tuberculosis across a broad range of CD4 strata."], "hard_negative": "Stroke patients with prior use of direct oral anticoagulants have a lower risk of in-hospital mortality than stroke patients with prior use of warfarin."}
{"query_id": "1107", "query_text": "Subcutaneous fat depots undergo extensive browning processes after cold exposure.", "negative": "Ly49Q directs the organization of neutrophil migration to inflammation sites by regulating membrane raft functions.", "negatives": ["Ly49Q directs the organization of neutrophil migration to inflammation sites by regulating membrane raft functions.", "Antiretroviral therapy reduces rates of tuberculosis across a broad range of CD4 strata.", "Epidemiological disease burden from noncommunicable diseases is more prevalent in low economic settings.", "Mutant mice lacking SVCT2 have greatly increased ascorbic acid levels in both brain and adrenals.", "MicroRNA is involved in the regulation of Neural Stem Cell (NSC) differentiation and proliferation dynamic homeostasis", "The ureABIEFGH gene cluster encodes urease maturation proteins : UreD/UreH, UreE, UreF, and UreG.", "HNF4A mutations can cause diabetes in mutant carriers by the age of 14 years", "Asymptomatic visual impairment screening in elderly populations does not lead to improved vision.", "p16INK4A accumulation is  linked to an abnormal wound response caused by the microinvasive step of advanced Oral Potentially Malignant Lesions (OPMLs).", "Normal expression of RUNX1 has tumor-promoting effects."], "hard_negatives": ["Subcutaneous fat depots undergo extensive browning processes after cold exposure.", "Obesity is determined solely by environmental factors.", "Macropinocytosis contributes to a cell's supply of amino acids via the intracellular uptake of protein.", "Bone marrow cells contribute to adult macrophage compartments.", "Ethanol stress decreases the expression of IBP in bacteria.", "Active H. pylori urease has a polymeric structure that compromises two subunits, UreA and UreB.", "Statins decrease blood cholesterol.", "High levels of copeptin decrease risk of diabetes.", "Suboptimal nutrition is not predictive of chronic disease", "Statins increase blood cholesterol."], "hard_negative": "Subcutaneous fat depots undergo extensive browning processes after cold exposure."}
{"query_id": "1110", "query_text": "Suboptimal nutrition is not predictive of chronic disease", "negative": "Tumor necrosis factor alpha (TNF-\u03b1) and interleukin-1 (IL-1) are pro-inflammatory cytokines that inhibit IL-6 and IL-10.", "negatives": ["Tumor necrosis factor alpha (TNF-\u03b1) and interleukin-1 (IL-1) are pro-inflammatory cytokines that inhibit IL-6 and IL-10.", "Chenodeosycholic acid treatment increases whole-body energy expenditure.", "In transgenic mice harboring green florescent protein under the control of the Sox2 promoter, less than ten percent of the cells with green florescent colocalize with cell proliferation markers.", "Reduced responsiveness to interleukin-2 in regulatory T cells is associated with greater resistance to autoimmune diseases such as Type 1 Diabetes.", "Cellular aging closely links to an older appearance.", "Localization of PIN1 in the roots of Arabidopsis does not require VPS9a", "The myocardial lineage develops from cardiac progenitors of mesodermal origin.", "Macrolides have no protective effect against myocardial infarction.", "Ly6C hi monocytes have a lower inflammatory capacity compared to their Ly6C lo counterparts.", "In young and middle-aged adults, current or remote uses of ADHD medications do not increase the risk of serious cardiovascular events."], "hard_negatives": ["Suboptimal nutrition is not predictive of chronic disease", "Obesity is determined solely by environmental factors.", "Epidemiological disease burden from noncommunicable diseases is more prevalent in low economic settings.", "Obesity decreases life quality.", "A high microerythrocyte count raises vulnerability to severe anemia in homozygous alpha (+)- thalassemia trait subjects.", "High levels of copeptin decrease risk of diabetes.", "Vitamin D deficiency is unrelated to birth weight.", "Functional consequences of genomic alterations due to Myelodysplastic syndrome (MDS) are poorly understood due to the lack of an animal model.", "Polymeal nutrition reduces cardiovascular mortality.", "Vitamin D deficiency effects the term of delivery."], "hard_negative": "Suboptimal nutrition is not predictive of chronic disease"}
{"query_id": "1121", "query_text": "Synaptic activity enhances local release of brain derived neurotrophic factor from postsynaptic dendrites.", "negative": "Mice without IFN-\u03b3 or its receptor are resistant to EAM induced with \u03b1-MyHC/CFA.", "negatives": ["Mice without IFN-\u03b3 or its receptor are resistant to EAM induced with \u03b1-MyHC/CFA.", "Combination nicotine replacement therapies with varenicline or bupropion lead to significantly higher long-term abstinence rates at 52 weeks than varenicline monotherapy.", "Less than 10% of the gabonese children with Schimmelpenning-Feuerstein-Mims syndrome (SFM) had a plasma lactate of more than 5mmol/L.", "Chenodeosycholic acid treatment increases whole-body energy expenditure.", "Febrile seizures reduce the threshold for development of epilepsy.", "The availability of safe places to study is not effective at decreasing homelessness.", "The PRR MDA5 is a sensor of RNA virus infection.", "Assembly of invadopodia is triggered by focal generation of phosphatidylinositol-3,4-biphosphate and the activation of the nonreceptor tyrosine kinase Src.", "5% of perinatal mortality is due to low birth weight.", "The YAP1 and TEAD complex tanslocates into the nucleus where it interacts with transcription factors and DNA-binding proteins that modulate target gene transcription."], "hard_negatives": ["Synaptic activity enhances local release of brain derived neurotrophic factor from postsynaptic dendrites.", "Hypothalamic glutamate neurotransmission is crucial to energy balance.", "Crosstalk between dendritic cells (DCs) and innate lymphoid cells (ILCs) is important in the regulation of intestinal homeostasis.", "PDPN promotes efficient motility along stromal surfaces by activating the C-type lectin receptor to rearrange the actin cytoskeleton in dendritic cells.", "Activator-inhibitor pairs are provided dorsally by Admpchordin.", "Ly49Q directs the organization of neutrophil migration to inflammation sites by regulating membrane raft functions.", "Fz/PCP-dependent Pk localizes to the anterior membrane of neuroectoderm cells during zebrafish neuralation", "ITAM phosphorylation prevents the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).", "The sliding activity of kinesin-8 protein Kip3 promotes bipolar spindle assembly.", "Pleiotropic coupling of GLP-1R to intracellular effectors promotes distinct profiles of cellular signaling."], "hard_negative": "Synaptic activity enhances local release of brain derived neurotrophic factor from postsynaptic dendrites."}
{"query_id": "1130", "query_text": "T regulatory cells (tTregs) lacking \u03b1v\u03b28 are more adept at suppressing pathogenic T-cell responses during active inflammation.", "negative": "Crosstalk between dendritic cells (DCs) and innate lymphoid cells (ILCs) is important in the regulation of intestinal homeostasis.", "negatives": ["Crosstalk between dendritic cells (DCs) and innate lymphoid cells (ILCs) is important in the regulation of intestinal homeostasis.", "There is an inverse relationship between hip fractures and statin use.", "There is an inverse relationship between hip fractures and statin use.", "The PPR MDA5 has two N-terminal CARD domains.", "T regulatory cells (tTregs) lacking \u03b1v\u03b28 are more adept at suppressing pathogenic T-cell responses during active inflammation.", "The PPR MDA5 has two N-terminal CARD domains.", "Antiretroviral therapy reduces rates of tuberculosis across a broad range of CD4 strata.", "Mitochondria are uninvolved in apoptosis.", "Autologous transplantation of mesenchymal stem cells causes a higher rate of opportunistic infections than induction therapy with anti-interleukin-2 receptor antibodies.", "The benefits of colchicine were achieved with effective widespread use of secondary prevention strategies such as high-dose statins."], "hard_negatives": ["T regulatory cells (tTregs) lacking \u03b1v\u03b28 are more adept at suppressing pathogenic T-cell responses during active inflammation.", "Reduced responsiveness to interleukin-2 in regulatory T cells is associated with greater resistance to autoimmune diseases such as Type 1 Diabetes.", "TCR/CD3 microdomains are a required to induce the immunologic synapse to activate T cells.", "Immune responses result in the development of inflammatory Th17 cells and anti-inflammatory iTregs.", "In adult tissue, most T cells are memory T cells.", "CX3CR1 on the Th2 cells promotes T cell survival", "Golli-deficient T-cells prefer to differentiate into an anergic phenotype in the adaptive immune response when there are increased levels of Ca2+ in the cytosol.", "Deletion of \u03b1v\u03b28 does not result in a spontaneous inflammatory phenotype.", "CX3CR1 on the Th2 cells impairs T cell survival", "UCB T cells reduce TCR diversity after transplantation."], "hard_negative": "T regulatory cells (tTregs) lacking \u03b1v\u03b28 are more adept at suppressing pathogenic T-cell responses during active inflammation."}
{"query_id": "1132", "query_text": "TCR/CD3 microdomains are a required to induce the immunologic synapse to activate T cells.", "negative": "ADAR1 binds to Dicer to cleave pre-miRNA.", "negatives": ["ADAR1 binds to Dicer to cleave pre-miRNA.", "CR is associated with higher methylation age.", "Leuko-increased blood increases infectious complications in red blood cell transfusion.", "Modifying the epigenome in the brain affects the normal human aging process by affecting certain genes related to neurogenesis.", "Most termination events in Okazaki fragments are sequence specific.", "The sliding activity of kinesin-8 protein Kip3 promotes bipolar spindle assembly.", "Radioiodine treatment of non-toxic multinodular goitre reduces thyroid volume.", "Fz/PCP-dependent Pk localizes to the anterior membrane of neuroectoderm cells during zebrafish neuralation", "New drugs for tuberculosis often do not penetrate the necrotic portion of a tuberculosis lesion in high concentrations.", "Increased microtubule acetylation repairs LRRK2 Roc-COR domain mutation induced locomotor deficits."], "hard_negatives": ["TCR/CD3 microdomains are a required to induce the immunologic synapse to activate T cells.", "ITAM phosphorylation prevents the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).", "T regulatory cells (tTregs) lacking \u03b1v\u03b28 are more adept at suppressing pathogenic T-cell responses during active inflammation.", "Reduced responsiveness to interleukin-2 in regulatory T cells is associated with greater resistance to autoimmune diseases such as Type 1 Diabetes.", "CX3CR1 on the Th2 cells promotes T cell survival", "CX3CR1 on the Th2 cells impairs T cell survival", "UCB T cells maintain high TCR diversity after transplantation.", "UCB T cells reduce TCR diversity after transplantation.", "In adult tissue, most T cells are memory T cells.", "Golli-deficient T-cells prefer to differentiate into an anergic phenotype in the adaptive immune response when there are increased levels of Ca2+ in the cytosol."], "hard_negative": "TCR/CD3 microdomains are a required to induce the immunologic synapse to activate T cells."}
{"query_id": "1137", "query_text": "TNFAIP3 is a tumor suppressor in glioblastoma.", "negative": "NOX2-independent pathways can generate peroxynitrite by reacting with nitrogen intermediates.", "negatives": ["NOX2-independent pathways can generate peroxynitrite by reacting with nitrogen intermediates.", "mTORC2 regulates intracellular cysteine levels through xCT inhibition.", "Leuko-increased blood increases infectious complications in red blood cell transfusion.", "Rapid phosphotransfer rates govern fidelity in two component systems", "Statins increase blood cholesterol.", "CHEK2 is not associated with breast cancer.", "Primary pro-inflammatory cytokines induce secondary pro- and anti-inflammatory mediators.", "Radioiodine treatment of non-toxic multinodular goitre reduces thyroid volume.", "Teaching hospitals do not provide better care than non-teaching hospitals.", "HNF4A mutations can cause diabetes in mutant carriers by the age of 14 years"], "hard_negatives": ["TNFAIP3 is a tumor suppressor in glioblastoma.", "Low expression of miR7a exerts a biological function in testis.", "Tumor necrosis factor alpha (TNF-\u03b1) and interleukin-1 (IL-1) are pro-inflammatory cytokines that inhibit IL-6 and IL-10.", "Low expression of miR7a does represses target genes and exerts a biological function in ovaries.", "The extracellular domain of TMEM27 is cleaved in human beta cells.", "ALDH1 expression is associated with better breast cancer outcomes.", "ALDH1 expression is associated with poorer prognosis in breast cancer.", "IRG1 has antiviral effects against neurotropic viruses.", "AMP-activated protein kinase (AMPK) activation increases inflammation-related fibrosis in the lungs.", "The locus rs647161 is associated with colorectal carcinoma."], "hard_negative": "TNFAIP3 is a tumor suppressor in glioblastoma."}
{"query_id": "1140", "query_text": "Taking 400mg of \u03b1-tocopheryl acetate helps to prevent prostate cancer.", "negative": "PGE 2 promotes intestinal tumor growth by altering the expression of tumor suppressing and DNA repair genes.", "negatives": ["PGE 2 promotes intestinal tumor growth by altering the expression of tumor suppressing and DNA repair genes.", "Mice defective for deoxyribonucleic acid (DNA) polymerase I (polI) reveal increased sensitivity to ionizing radiation (IR).", "Venules have a thinner or absent smooth layer compared to arterioles.", "Ivermectin is used to treat lymphatic filariasis.", "Fz/PCP-dependent Pk localizes to the anterior membrane of notochord cells during zebrafish neuralation.", "Albendazole is used to treat lymphatic filariasis.", "Low nucleosome occupancy correlates with low methylation levels across species.", "Diabetic patients with acute coronary syndrome experience increased short-term and long-term risk for bleeding events.", "The availability of safe places to study is not effective at decreasing homelessness.", "The combination of H3K4me3 and H3K79me2 is found in quiescent hair follicle stem cells."], "hard_negatives": ["Taking 400mg of \u03b1-tocopheryl acetate helps to prevent prostate cancer.", "Sildenafil improves erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.", "Dexamethasone decreases risk of postoperative bleeding.", "Combination nicotine replacement therapies with varenicline or bupropion lead to significantly higher long-term abstinence rates at 52 weeks than varenicline monotherapy.", "The risk of breast cancer among parous women increases with placental weight of pregnancies, and this association is strongest for premenopausal breast cancer.", "Metastatic colorectal cancer treated with a single agent fluoropyrimidines resulted in reduced efficacy and lower quality of life when compared with oxaliplatin-based chemotherapy in elderly patients.", "The relationship between a breast cancer patient's capacity to metabolize tamoxifen and treatment outcome is dependent on the patient's genetic make-up.", "The treatment of cancer patients with co-IR blockade does not cause any adverse autoimmune events.", "Varenicline monotherapy is more effective after 12 weeks of treatment compared to combination nicotine replacement therapies with varenicline or bupropion.", "Mercaptopurine is anabolized into the inactive methylmercaptopurine by thiopurine methyltrasnferase (TPMT)."], "hard_negative": "Taking 400mg of \u03b1-tocopheryl acetate helps to prevent prostate cancer."}
{"query_id": "1144", "query_text": "Taxation of sugar-sweetened beverages had no effect on the incidence rate of type II diabetes in India.", "negative": "The treatment of cancer patients with co-IR blockade precipitates adverse autoimmune events.", "negatives": ["The treatment of cancer patients with co-IR blockade precipitates adverse autoimmune events.", "Pretreatment with the Arp2/3 inhibitor CK-666 affects lamelliopodia formation.", "Febrile seizures reduce the threshold for development of epilepsy.", "Peroxynitrite is required for nitration of TCR/CD8.", "Primary cervical cancer screening with HPV detection has higher longitudinal sensitivity than conventional cytology to detect cervical intraepithelial neoplasia grade 2.", "0-dimensional biomaterials show inductive properties.", "Macrolides have no protective effect against myocardial infarction.", "Dexamethasone decreases risk of postoperative bleeding.", "There is an inverse relationship between hip fractures and statin use.", "Leuko-reduced blood reduces infectious complications in red blood cell transfusion."], "hard_negatives": ["Taxation of sugar-sweetened beverages had no effect on the incidence rate of type II diabetes in India.", "Carriers of the alcohol aldehyde dehydrogenase deficiency mutation drink less that non-carries.", "Hypertension is frequently observed in type 1 diabetes patients.", "Hypoglycemia increases the risk of dementia.", "LDL cholesterol has no involvement in the development of cardiovascular disease.", "High dietary calcium intakes are unnecessary for prevention of secondary hyperparathyroidism in subjects with 25(OH)D levels above 75 nmol/liter.", "Insulin increases risk of severe kidney failure.", "Obesity is determined solely by environmental factors.", "Angiotensin converting enzyme inhibitors are associated with increased risk for functional renal insufficiency.", "Sildenafil improves erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants."], "hard_negative": "Taxation of sugar-sweetened beverages had no effect on the incidence rate of type II diabetes in India."}
{"query_id": "1146", "query_text": "Teaching hospitals do not provide better care than non-teaching hospitals.", "negative": "NF2 (Merlin) causes phosphorylation and subsequent cytoplasmic sequestration of YAP in Drosophila by activating LATS1/2 kinases.", "negatives": ["NF2 (Merlin) causes phosphorylation and subsequent cytoplasmic sequestration of YAP in Drosophila by activating LATS1/2 kinases.", "Activator-inhibitor pairs are provided dorsally by Admpchordin.", "PDPN promotes efficient motility along stromal surfaces by activating the C-type lectin receptor to rearrange the actin cytoskeleton in dendritic cells.", "Autologous transplantation of mesenchymal stem cells causes a higher rate of opportunistic infections than induction therapy with anti-interleukin-2 receptor antibodies.", "The center of the granuloma in an immune cell induces a pro-inflammatory immune response.", "Rapid phosphotransfer rates govern fidelity in two component systems", "The treatment of cancer patients with co-IR blockade precipitates adverse autoimmune events.", "A deficiency of vitamin B12 increases blood levels of homocysteine.", "Ivermectin is used to treat lymphatic filariasis.", "Nanoparticles can be targeted against specific cell types by incorporating aptamers into lipid nanoparticles."], "hard_negatives": ["Teaching hospitals do not provide better care than non-teaching hospitals.", "Healthcare delivery efficiency in crowded delivery centers is impaired by improving structural, logistical, and interpersonal elements.", "Bariatric surgery has a positive impact on mental health.", "Patients in stable partnerships have a faster progression from HIV to AIDS.", "The availability of safe places to study is not effective at decreasing homelessness.", "Articles published in open access format are less likely to be cited than traditional journals.", "Input from  mental and physical health care professionals is effective at decreasing homelessness.", "The availability of safe places to study is effective at decreasing homelessness.", "Articles published in open access format are more likely to be cited than traditional journals.", "Epidemiological disease burden from noncommunicable diseases is more prevalent in low economic settings."], "hard_negative": "Teaching hospitals do not provide better care than non-teaching hospitals."}
{"query_id": "1150", "query_text": "Tetraspanin-3 is a causative factor in the development of acute myelogenous leukemia", "negative": "Mutations in G-Beta protein GNB2 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.", "negatives": ["Mutations in G-Beta protein GNB2 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.", "The minor G allele of FOXO3 is related to more severe symptoms of Crohn's Disease.", "Autologous transplantation of mesenchymal stem cells causes a higher rate of opportunistic infections than induction therapy with anti-interleukin-2 receptor antibodies.", "Homozygous deletion of murine Sbds gene from osterix-expressing mesenchymal stem and progenitor cells (MPCs) prevents oxidative stress.", "Bone marrow cells contribute to adult macrophage compartments.", "Auditory entrainment is strengthened when people see congruent visual and auditory information.", "Angiotensin converting enzyme inhibitors are associated with increased risk for functional renal insufficiency.", "Omnivores produce less trimethylamine N-oxide from dietary I-carnitine than vegetarians.", "Mice defective for deoxyribonucleic acid (DNA) polymerase I (polI) reveal increased sensitivity to ionizing radiation (IR).", "Birth-weight is positively associated with breast cancer."], "hard_negatives": ["Tetraspanin-3 is a causative factor in the development of acute myelogenous leukemia", "Human T-lymphotropic virus type-I-associated myelopathy / tropical spastic paraparesis (HAM/TSP) patients produce Immunoglobulin G (IgG) antibodies which cross-react with an immunodominant epitope in Tax.", "Leukemia associated Rho guanine nucleotide-exchange factor represses RhoA in response to SRC activation.", "N348I mutations cause resistance to zidovudine (AZT).", "Mice that lack Interferon-\u03b3 or its receptor exhibit high resistance to experimental autoimmune myocarditis.", "Ivermectin is used to treat lymphatic filariasis.", "Albendazole is used to treat lymphatic filariasis.", "TNFAIP3 is a tumor suppressor in glioblastoma.", "Metastatic colorectal cancer treated with a single agent fluoropyrimidines resulted in reduced efficacy and lower quality of life when compared with oxaliplatin-based chemotherapy in elderly patients.", "CHEK2 is not associated with breast cancer."], "hard_negative": "Tetraspanin-3 is a causative factor in the development of acute myelogenous leukemia"}
{"query_id": "1163", "query_text": "The DdrB protein from Deinococcus radiodurans is an alternative SSB.", "negative": "The benefits of colchicine were achieved with effective widespread use of secondary prevention strategies such as high-dose statins.", "negatives": ["The benefits of colchicine were achieved with effective widespread use of secondary prevention strategies such as high-dose statins.", "The treatment of cancer patients with co-IR blockade precipitates adverse autoimmune events.", "Ivermectin is used to treat onchocerciasis.", "Incidence of heart failure decreased by 10% in women since 1979.", "Statins increase blood cholesterol.", "Occupancy of ribosomes by IncRNAs mirror 5 0-UTRs", "PKG-la plays an essential role in expression of pain hypersensitivity in PGK-la knockout mice.", "aPKCz causes tumour enhancement by affecting glutamine metabolism.", "Cells undergoing methionine restriction may activate miRNAs.", "Recurrent mutations occur frequently within CTCF anchor sites adjacent to oncogenes."], "hard_negatives": ["The DdrB protein from Deinococcus radiodurans is an alternative SSB.", "The PRR MDA5 has a central DExD/H RNA helices domain.", "The PPR MDA5 has two N-terminal CARD domains.", "Helminths interfere with immune system control of macrophages activated by IL-4 favor Mycobacterium tuberculosis replication.", "The PRR MDA5 is a sensor of RNA virus infection.", "Active H. pylori urease has a polymeric structure that compromises two subunits, UreA and UreB.", "Peroxynitrite is required for nitration of TCR/CD8.", "The treatment of cancer patients with co-IR blockade precipitates adverse autoimmune events.", "N348I mutations cause resistance to zidovudine (AZT).", "The treatment of cancer patients with co-IR blockade does not cause any adverse autoimmune events."], "hard_negative": "The DdrB protein from Deinococcus radiodurans is an alternative SSB."}
{"query_id": "1175", "query_text": "The PPR MDA5 has two N-terminal CARD domains.", "negative": "ADAR1 binds to Dicer to cleave pre-miRNA.", "negatives": ["ADAR1 binds to Dicer to cleave pre-miRNA.", "CX3CR1 on the Th2 cells impairs T cell survival", "Fz/PCP-dependent Pk localizes to the anterior membrane of neuroectoderm cells during zebrafish neuralation", "The ureABIEFGH gene cluster is induced by nickel (II) ion.", "Hypoglycemia increases the risk of dementia.", "NOX2-independent pathways can generate peroxynitrite by reacting with nitrogen intermediates.", "Activation of PPM1D suppresses p53 function.", "Less than 10% of the gabonese children with Schimmelpenning-Feuerstein-Mims syndrome (SFM) had a plasma lactate of more than 5mmol/L.", "FoxO3a activation in neuronal death is mediated by reactive oxygen species (ROS).", "Incidence rates of cervical cancer have increased due to nationwide screening programs based primarily on cytology to detect uterine cervical cancer."], "hard_negatives": ["The PPR MDA5 has two N-terminal CARD domains.", "The PRR MDA5 has a central DExD/H RNA helices domain.", "The PRR MDA5 is a sensor of RNA virus infection.", "ADAR1 binds to Dicer to cleave pre-miRNA.", "PPAR-RXRs can be activated by PPAR ligands.", "Occupancy of ribosomes by IncRNAs mirror 5 0-UTRs", "Alizarin forms hydrogen bonds with residues involved in PGAM1 substrate binding.", "N348I mutations cause resistance to zidovudine (AZT).", "PPAR-RXRs are inhibited by PPAR ligands.", "Commelina yellow mottle virus' (ComYMV) genome consists of 7489 baise pairs."], "hard_negative": "The PPR MDA5 has two N-terminal CARD domains."}
{"query_id": "1179", "query_text": "The PRR MDA5 has a central DExD/H RNA helices domain.", "negative": "Podocytes are motile and migrate in the presence of injury.", "negatives": ["Podocytes are motile and migrate in the presence of injury.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have increased risk for dementia.", "Bone marrow cells contribute to adult macrophage compartments.", "0-dimensional biomaterials show inductive properties.", "A total of 1,000 people in the UK are asymptomatic carriers of vCJD infection.", "Cold exposure reduces BAT recruitment.", "Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have a dramatic impact in reducing malaria transmission.", "Pyridostatin destabilizes the G - quadruplex in the telomeric region.", "Modifying the epigenome in the brain affects the normal human aging process by affecting certain genes related to neurogenesis.", "The risk of male prisoners harming themselves is ten times that of female prisoners."], "hard_negatives": ["The PRR MDA5 has a central DExD/H RNA helices domain.", "The PPR MDA5 has two N-terminal CARD domains.", "The PRR MDA5 is a sensor of RNA virus infection.", "The DdrB protein from Deinococcus radiodurans is an alternative SSB.", "PPAR-RXRs can be activated by PPAR ligands.", "PPAR-RXRs are inhibited by PPAR ligands.", "Occupancy of ribosomes by IncRNAs mirror 5 0-UTRs", "N348I mutations cause resistance to zidovudine (AZT).", "GATA-3 is important for hematopoietic stem cell (HSC) function.", "ADAR1 binds to Dicer to cleave pre-miRNA."], "hard_negative": "The PRR MDA5 has a central DExD/H RNA helices domain."}
{"query_id": "1180", "query_text": "The PRR MDA5 is a sensor of RNA virus infection.", "negative": "Subcutaneous fat depots undergo extensive browning processes after cold exposure.", "negatives": ["Subcutaneous fat depots undergo extensive browning processes after cold exposure.", "The treatment of cancer patients with co-IR blockade precipitates adverse autoimmune events.", "ALDH1 expression is associated with better breast cancer outcomes.", "The center of the granuloma in an immune cell induces a pro-inflammatory immune response.", "A high microerythrocyte count raises vulnerability to severe anemia in homozygous alpha (+)- thalassemia trait subjects.", "Modifying the epigenome in the brain affects the normal human aging process by affecting certain genes related to neurogenesis.", "MicroRNA is involved in the regulation of Neural Stem Cell (NSC) differentiation and proliferation dynamic homeostasis", "CR is associated with higher methylation age.", "cSMAC formation enhances weak ligand signalling.", "Suboptimal nutrition is not predictive of chronic disease"], "hard_negatives": ["The PRR MDA5 is a sensor of RNA virus infection.", "The PPR MDA5 has two N-terminal CARD domains.", "The PRR MDA5 has a central DExD/H RNA helices domain.", "The DdrB protein from Deinococcus radiodurans is an alternative SSB.", "IRG1 has antiviral effects against neurotropic viruses.", "Occupancy of ribosomes by IncRNAs mirror 5 0-UTRs", "Low expression of miR7a exerts a biological function in testis.", "Helminths interfere with immune system control of macrophages activated by IL-4 favor Mycobacterium tuberculosis replication.", "Occupancy of ribosomes by IncRNAs do not make functional peptides.", "Enhanced early production of inflammatory chemokines improves viral control in the lung."], "hard_negative": "The PRR MDA5 is a sensor of RNA virus infection."}
{"query_id": "1185", "query_text": "The US health care system can save up to $750 million if 7% of patients waiting for kidney transplants participate in the optimized national kidney paired donation program.", "negative": "Incidence rates of cervical cancer have increased due to nationwide screening programs based primarily on cytology to detect uterine cervical cancer.", "negatives": ["Incidence rates of cervical cancer have increased due to nationwide screening programs based primarily on cytology to detect uterine cervical cancer.", "cSMAC formation enhances weak ligand signalling.", "Many proteins in human cells can be post-translationally modified at lysine residues via acetylation.", "Thigh-length graduated compression stockings (GCS) did not reduce deep vein thrombosis in patients admitted to hospital who are immobile because of acute stroke.", "Radioiodine treatment of non-toxic multinodular goitre reduces thyroid volume.", "Cold exposure increases BAT recruitment.", "Diabetic patients with acute coronary syndrome experience increased short-term and long-term risk for bleeding events.", "The locus rs647161 is associated with colorectal carcinoma.", "Hypertension is frequently observed in type 1 diabetes patients.", "There is an inverse relationship between hip fractures and statin use."], "hard_negatives": ["The US health care system can save up to $750 million if 7% of patients waiting for kidney transplants participate in the optimized national kidney paired donation program.", "Angiotensin converting enzyme inhibitors are associated with increased risk for functional renal insufficiency.", "Insulin increases risk of severe kidney failure.", "CRP is not predictive of postoperative mortality following Coronary Artery Bypass Graft (CABG) surgery.", "Autologous transplantation of mesenchymal stem cells has lower rates of rejection than induction therapy with anti-interleukin-2 receptor antibodies.", "Incidence of heart failure decreased by 10% in women since 1979.", "Autologous transplantation of mesenchymal stem cells causes a higher rate of opportunistic infections than induction therapy with anti-interleukin-2 receptor antibodies.", "The relationship between a breast cancer patient's capacity to metabolize tamoxifen and treatment outcome is dependent on the patient's genetic make-up.", "Transplanted human glial cells can differentiate within the host animal.", "Autologous transplantation of mesenchymal stem cells causes fewer opportunistic infections than induction therapy with anti-interleukin-2 receptor antibodies."], "hard_negative": "The US health care system can save up to $750 million if 7% of patients waiting for kidney transplants participate in the optimized national kidney paired donation program."}
{"query_id": "1187", "query_text": "The YAP1 and TEAD complex tanslocates into the nucleus where it interacts with transcription factors and DNA-binding proteins that modulate target gene transcription.", "negative": "Women with a higher birth weight are more likely to develop breast cancer later in life.", "negatives": ["Women with a higher birth weight are more likely to develop breast cancer later in life.", "Fz/PCP-dependent Pk localizes to the anterior membrane of notochord cells during zebrafish neuralation.", "The relationship between a breast cancer patient's capacity to metabolize tamoxifen and treatment outcome is dependent on the patient's genetic make-up.", "Bariatric surgery has a positive impact on mental health.", "Tumor necrosis factor alpha (TNF-\u03b1) and interleukin-1 (IL-1) are pro-inflammatory cytokines that inhibit IL-6 and IL-10.", "Occupancy of ribosomes by IncRNAs do not make functional peptides.", "Pseudogene PTENP1 regulates the expression of PTEN by functioning as an miRNA decoy.", "Antibiotic induced alterations in the gut microbiome reduce resistance against Clostridium difficile", "Anthrax spores can be disposed of easily after they are dispersed.", "Nanoparticles can be targeted against specific cell types by incorporating aptamers into lipid nanoparticles."], "hard_negatives": ["The YAP1 and TEAD complex tanslocates into the nucleus where it interacts with transcription factors and DNA-binding proteins that modulate target gene transcription.", "ITAM phosphorylation prevents the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).", "Histone demethylase recruitment and a transient decrease in histone methylation is necessary for ligand-dependent induction of transcription by nuclear receptors.", "NF2 (Merlin) causes phosphorylation and subsequent cytoplasmic sequestration of YAP in Drosophila by activating LATS1/2 kinases.", "PDPN promotes efficient motility along stromal surfaces by activating the C-type lectin receptor to rearrange the actin cytoskeleton in dendritic cells.", "NF2 (Merlin) prevents phosphorylation and subsequent cytoplasmic sequestration of YAP in Drosophila.", "Localization of PIN1 in the Arabidopsis embryo does not require VPS9a", "Smc5/6 engagment drives the activation of SUMO E3 ligase Mms21 by ATP-dependent remolding.", "The ureABIEFGH gene cluster encodes urease maturation proteins : UreD/UreH, UreE, UreF, and UreG.", "Localization of PIN1 in the roots of Arabidopsis does not require VPS9a"], "hard_negative": "The YAP1 and TEAD complex tanslocates into the nucleus where it interacts with transcription factors and DNA-binding proteins that modulate target gene transcription."}
{"query_id": "1191", "query_text": "The amount of publicly available DNA data doubles every 10 years.", "negative": "Activation of PPM1D suppresses p53 function.", "negatives": ["Activation of PPM1D suppresses p53 function.", "Combining phosphatidylinositide 3-kinase and MEK 1/2 inhibitors is effective at treating KRAS mutant tumors.", "Individuals with low serum vitamin D concentrations have increased risk of multiple sclerosis.", "Cataract and trachoma are the primary cause of blindness in Southern Sudan.", "Most termination events in Okazaki fragments are sequence specific.", "Podocytes are motile and migrate in the presence of injury.", "Occupancy of ribosomes by IncRNAs mirror 5 0-UTRs", "Subcutaneous fat depots undergo extensive browning processes after cold exposure.", "Incidence rates of cervical cancer have decreased.", "Mice without IFN-\u03b3 or its receptor are resistant to EAM induced with \u03b1-MyHC/CFA."], "hard_negatives": ["The amount of publicly available DNA data doubles every 10 years.", "1,000 genomes project enables mapping of genetic sequence variation consisting of rare variants with larger penetrance effects than common variants.", "5% of perinatal mortality is due to low birth weight.", "Low nucleosome occupancy correlates with low methylation levels across species.", "Incidence rates of cervical cancer have decreased.", "De novo assembly of sequence data has more specific contigs than unassembled sequence data.", "Birth-weight is positively associated with breast cancer.", "Articles published in open access format are more likely to be cited than traditional journals.", "Vitamin D deficiency is unrelated to birth weight.", "Articles published in open access format are less likely to be cited than traditional journals."], "hard_negative": "The amount of publicly available DNA data doubles every 10 years."}
{"query_id": "1194", "query_text": "The arm density of TatAd complexes is due to structural rearrangements within Class1 TatAd complexes such as the 'charge zipper mechanism'.", "negative": "Birth-weight is positively associated with breast cancer.", "negatives": ["Birth-weight is positively associated with breast cancer.", "In transgenic mice harboring green florescent protein under the control of the Sox2 promoter, less than ten percent of the cells with green florescent colocalize with cell proliferation markers.", "In mice, P. chabaudi parasites are able to proliferate faster early in infection when inoculated at lower numbers than when inoculated at high numbers.", "APOE4 expression in iPSC-derived neurons increases AlphaBeta production and tau phosphorylation causing GABA neuron degeneration.", "Chronic aerobic exercise alters endothelial function, improving vasodilating mechanisms mediated by NO.", "IgA plasma cells that are specific for transglutaminase 2 accumulate in the duodenal mucosa on commencement of a gluten-free diet.", "CX3CR1 on the Th2 cells promotes T cell survival", "NFAT4 activation requires IP3R-mediated Ca2+ mobilization.", "Increased microtubule acetylation repairs LRRK2 Roc-COR domain mutation induced locomotor deficits.", "Cytosolic proteins bind to iron-responsive elements on mRNAs coding for DMT1. Cytosolic proteins bind to iron-responsive elements on mRNAs coding for proteins involved in iron uptake."], "hard_negatives": ["The arm density of TatAd complexes is due to structural rearrangements within Class1 TatAd complexes such as the 'charge zipper mechanism'.", "Many proteins in human cells can be post-translationally modified at lysine residues via acetylation.", "Pyridostatin destabilizes the G - quadruplex in the telomeric region.", "The ureABIEFGH gene cluster is induced by nickel (II) ion.", "Cytosolic proteins bind to iron-responsive elements on mRNAs coding for DMT1. Cytosolic proteins bind to iron-responsive elements on mRNAs coding for proteins involved in iron uptake.", "Mutations in G-Beta protein GNB2 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.", "Discrimination between the initiator and elongation tRNAs depends on the translation initiation factor IF3.", "Occupancy of ribosomes by IncRNAs do not make functional peptides.", "mTORC2 regulates intracellular cysteine levels through xCT inhibition.", "Ly49Q directs the organization of neutrophil migration to inflammation sites by regulating membrane raft functions."], "hard_negative": "The arm density of TatAd complexes is due to structural rearrangements within Class1 TatAd complexes such as the 'charge zipper mechanism'."}
{"query_id": "1196", "query_text": "The availability of safe places to study is effective at decreasing homelessness.", "negative": "Commelina yellow mottle virus' (ComYMV) genome consists of 7489 baise pairs.", "negatives": ["Commelina yellow mottle virus' (ComYMV) genome consists of 7489 baise pairs.", "Deletion of \u03b1v\u03b28 does not result in a spontaneous inflammatory phenotype.", "Mice defective for deoxyribonucleic acid (DNA) polymerase I (polI) reveal increased sensitivity to ionizing radiation (IR).", "Lymphadenopathy is observed in knockin mouse lacking the SHP-2 MAPK pathway.", "Low expression of miR7a does represses target genes and exerts a biological function in ovaries.", "The DdrB protein from Deinococcus radiodurans is an alternative SSB.", "Albendazole is used to treat lymphatic filariasis.", "Therapeutic use of the drug Dapsone to treat pyoderma gangrenous is based on anecdotal evidence.", "Breast cancer development is determined exclusively by genetic factors.", "The combination of H3K4me3 and H3K79me2 is found in quiescent hair follicle stem cells."], "hard_negatives": ["The availability of safe places to study is effective at decreasing homelessness.", "The availability of safe places to study is not effective at decreasing homelessness.", "Input from  mental and physical health care professionals is effective at decreasing homelessness.", "Healthcare delivery efficiency in crowded delivery centers is impaired by improving structural, logistical, and interpersonal elements.", "Insomnia can be effectively treated with cognitive behavioral therapy.", "Obesity is determined solely by environmental factors.", "In young and middle-aged adults, current or remote uses of ADHD medications do not increase the risk of serious cardiovascular events.", "Integrating classroom-based collaborative learning with Web-based collaborative learning leads to subpar class performance", "Patients in stable partnerships have a faster progression from HIV to AIDS.", "Non-invasive ventilation use should be decreased if there is inadequate response to conventional treatment."], "hard_negative": "The availability of safe places to study is effective at decreasing homelessness."}
{"query_id": "1197", "query_text": "The availability of safe places to study is not effective at decreasing homelessness.", "negative": "Incidence rates of cervical cancer have decreased.", "negatives": ["Incidence rates of cervical cancer have decreased.", "Less than 10% of the gabonese children with Schimmelpenning-Feuerstein-Mims syndrome (SFM) had a plasma lactate of more than 5mmol/L.", "1/2000 in UK have abnormal PrP positivity.", "NF2 (Merlin) prevents phosphorylation and subsequent cytoplasmic sequestration of YAP in Drosophila.", "Teaching hospitals do not provide better care than non-teaching hospitals.", "PPAR-RXRs can be activated by PPAR ligands.", "Transplanted human glial cells can differentiate within the host animal.", "Immune responses result in the development of inflammatory Th17 cells and anti-inflammatory iTregs.", "Transplanted human glial progenitor cells are incapable of forming a neural network with host animals' neurons.", "PDPN promotes efficient motility along stromal surfaces by activating the C-type lectin receptor to rearrange the actin cytoskeleton in dendritic cells."], "hard_negatives": ["The availability of safe places to study is not effective at decreasing homelessness.", "The availability of safe places to study is effective at decreasing homelessness.", "Input from  mental and physical health care professionals is effective at decreasing homelessness.", "Healthcare delivery efficiency in crowded delivery centers is impaired by improving structural, logistical, and interpersonal elements.", "In young and middle-aged adults, current or remote uses of ADHD medications do not increase the risk of serious cardiovascular events.", "Obesity is determined solely by environmental factors.", "Insomnia can be effectively treated with cognitive behavioral therapy.", "Non-invasive ventilation use should be decreased if there is inadequate response to conventional treatment.", "Patients in stable partnerships have a faster progression from HIV to AIDS.", "The one-child policy has been successful in lowering population growth."], "hard_negative": "The availability of safe places to study is not effective at decreasing homelessness."}
{"query_id": "1199", "query_text": "The benefits of colchicine were achieved with effective widespread use of secondary prevention strategies such as high-dose statins.", "negative": "NF2 (Merlin) causes phosphorylation and subsequent cytoplasmic sequestration of YAP in Drosophila by activating LATS1/2 kinases.", "negatives": ["NF2 (Merlin) causes phosphorylation and subsequent cytoplasmic sequestration of YAP in Drosophila by activating LATS1/2 kinases.", "Polymeal nutrition reduces cardiovascular mortality.", "mTORC2 regulates intracellular cysteine levels through xCT inhibition.", "DMRT1 is a sex-determining gene that is epigenetically regulated by the MHM region.", "Healthcare delivery efficiency in crowded delivery centers is impaired by improving structural, logistical, and interpersonal elements.", "Arginine 90 in p150n is important for interaction with EB1.", "Ly6C hi monocytes have a lower inflammatory capacity than Ly6C lo monocytes.", "Taking 400mg of \u03b1-tocopheryl acetate helps to prevent prostate cancer.", "De novo assembly of sequence data has more specific contigs than unassembled sequence data.", "The deregulated and prolonged activation of monocytes has deleterious effects in inflammatory diseases."], "hard_negatives": ["The benefits of colchicine were achieved with effective widespread use of secondary prevention strategies such as high-dose statins.", "Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have a dramatic impact in reducing malaria transmission.", "Antiretroviral therapy reduces rates of tuberculosis across a broad range of CD4 strata.", "Varenicline monotherapy is more effective after 12 weeks of treatment compared to combination nicotine replacement therapies with varenicline or bupropion.", "Mice that lack Interferon-\u03b3 or its receptor exhibit high resistance to experimental autoimmune myocarditis.", "Stroke patients with prior use of direct oral anticoagulants have a lower risk of in-hospital mortality than stroke patients with prior use of warfarin.", "Dexamethasone decreases risk of postoperative bleeding.", "Sildenafil improves erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.", "The treatment of cancer patients with co-IR blockade precipitates adverse autoimmune events.", "The treatment of cancer patients with co-IR blockade does not cause any adverse autoimmune events."], "hard_negative": "The benefits of colchicine were achieved with effective widespread use of secondary prevention strategies such as high-dose statins."}
{"query_id": "1200", "query_text": "The binding orientation of the ML-SA1 activator at hTRPML2 is different from the binding orientation of the ML-SA1 activator at hTRPML1.", "negative": "Basophils counteract disease development in patients with systemic lupus erythematosus (SLE).", "negatives": ["Basophils counteract disease development in patients with systemic lupus erythematosus (SLE).", "Hyperfibrinogenemia decreases rates of femoropopliteal bypass thrombosis.", "Activation of PPM1D suppresses p53 function.", "Taking 400mg of \u03b1-tocopheryl acetate helps to prevent prostate cancer.", "Lymphadenopathy is observed in knockin mouse lacking the SHP-2 MAPK pathway.", "Autologous transplantation of mesenchymal stem cells causes a higher rate of opportunistic infections than induction therapy with anti-interleukin-2 receptor antibodies.", "Statins increase blood cholesterol.", "Many proteins in human cells can be post-translationally modified at lysine residues via acetylation.", "Headaches are not correlated with cognitive impairment.", "Cell autonomous sex determination in somatic cells occurs in Passeriformes."], "hard_negatives": ["The binding orientation of the ML-SA1 activator at hTRPML2 is different from the binding orientation of the ML-SA1 activator at hTRPML1.", "PDPN promotes efficient motility along stromal surfaces by activating the C-type lectin receptor to rearrange the actin cytoskeleton in dendritic cells.", "Smc5/6 engagment drives the activation of SUMO E3 ligase Mms21 by ATP-dependent remolding.", "Inositol lipid 3-phosphatase PTEN converts Ptdlns(3,4)P 2 into phosphatidylinositol 4-phosphate.", "PPAR-RXRs can be activated by PPAR ligands.", "The PPR MDA5 has two N-terminal CARD domains.", "Ly49Q directs the organization of neutrophil migration to inflammation sites by regulating membrane raft functions.", "Discrimination between the initiator and elongation tRNAs depends on the translation initiation factor IF3.", "PPAR-RXRs are inhibited by PPAR ligands.", "The PRR MDA5 has a central DExD/H RNA helices domain."], "hard_negative": "The binding orientation of the ML-SA1 activator at hTRPML2 is different from the binding orientation of the ML-SA1 activator at hTRPML1."}
{"query_id": "1202", "query_text": "The center of the granuloma in an immune cell induces a pro-inflammatory immune response.", "negative": "Epidemiological disease burden from noncommunicable diseases is more prevalent in low economic settings.", "negatives": ["Epidemiological disease burden from noncommunicable diseases is more prevalent in low economic settings.", "Pretreatment with the Arp2/3 inhibitor CK-666 affects lamelliopodia formation.", "Monoclonal antibody targeting of N-cadherin inhibits metastasis.", "Neutrophil extracellular traps (NETs) are released by ANCA-stimulated neutrophils.", "Occupancy of ribosomes by IncRNAs mirror 5 0-UTRs", "0-dimensional biomaterials show inductive properties.", "AMP-activated protein kinase (AMPK) activation increases inflammation-related fibrosis in the lungs.", "Low expression of miR7a does represses target genes and exerts a biological function in ovaries.", "PPAR-RXRs can be activated by PPAR ligands.", "Pleiotropic coupling of GLP-1R to intracellular effectors promotes distinct profiles of cellular signaling."], "hard_negatives": ["The center of the granuloma in an immune cell induces a pro-inflammatory immune response.", "Immune complex triggered cell death leads to extracellular release of neutrophil protein HMGB1.", "Increased vessel density along with a reduction in fibrosis decreases the efficacy of chemotherapy treatments.", "Only a minority of cells survive development after differentiation into stress-resistant spores.", "Podocytes are motile and migrate in the presence of injury.", "Immune responses result in the development of inflammatory Th17 cells and anti-inflammatory iTregs.", "Flexible molecules experience greater steric hindrance in the tumor microenviroment than rigid molecules.", "During the primary early antibody response activated B cells migrate toward the inner-and outer paracortical areas where oxysterol accumulation is generated by stromal cells.", "Crosstalk between dendritic cells (DCs) and innate lymphoid cells (ILCs) is important in the regulation of intestinal homeostasis.", "The deregulated and prolonged activation of monocytes has deleterious effects in inflammatory diseases."], "hard_negative": "The center of the granuloma in an immune cell induces a pro-inflammatory immune response."}
{"query_id": "1204", "query_text": "The combination of H3K4me3 and H3K79me2 is found in quiescent hair follicle stem cells.", "negative": "Bariatric surgery has a positive impact on mental health.", "negatives": ["Bariatric surgery has a positive impact on mental health.", "Flexible molecules experience greater steric hindrance in the tumor microenviroment than rigid molecules.", "Febrile seizures increase the threshold for development of epilepsy.", "CX3CR1 on the Th2 cells suppresses airway inflammation.", "The ureABIEFGH gene cluster encodes urease maturation proteins : UreD/UreH, UreE, UreF, and UreG.", "The binding orientation of the ML-SA1 activator at hTRPML2 is different from the binding orientation of the ML-SA1 activator at hTRPML1.", "FoxO3a activation in neuronal death is mediated by reactive oxygen species (ROS).", "Obesity decreases life quality.", "Antibiotic induced alterations in the gut microbiome reduce resistance against Clostridium difficile", "Activation of PPM1D suppresses p53 function."], "hard_negatives": ["The combination of H3K4me3 and H3K79me2 is found in quiescent hair follicle stem cells.", "The extracellular domain of TMEM27 is cleaved in human beta cells.", "Ubiquitin ligase UBC13 generates a K63-linked polyubiquitin moiety at PCNA K164.", "MicroRNA is involved in the regulation of Neural Stem Cell (NSC) differentiation and proliferation dynamic homeostasis", "The sliding activity of kinesin-8 protein Kip3 promotes bipolar spindle assembly.", "PDPN promotes efficient motility along stromal surfaces by activating the C-type lectin receptor to rearrange the actin cytoskeleton in dendritic cells.", "NR5A2 is important in development of endometrial tissues.", "In transgenic mice harboring green florescent protein under the control of the Sox2 promoter, less than ten percent of the cells with green florescent colocalize with cell proliferation markers.", "Proteins synthesized at the growth cone are ubiquitinated at a higher rate than proteins from the cell body.", "CHEK2 is not associated with breast cancer."], "hard_negative": "The combination of H3K4me3 and H3K79me2 is found in quiescent hair follicle stem cells."}
{"query_id": "1207", "query_text": "The composition of myosin-II isoform switches from the polarizable B isoform to the more homogenous A isoform during hematopoietic differentiation.", "negative": "Subcutaneous fat depots undergo extensive browning processes after cold exposure.", "negatives": ["Subcutaneous fat depots undergo extensive browning processes after cold exposure.", "Angiotensin converting enzyme inhibitors are associated with increased risk for functional renal insufficiency.", "All hematopoietic stem cells segregate their chromosomes randomly.", "Macropinocytosis contributes to a cell's supply of amino acids via the intracellular uptake of protein.", "In mice, P. chabaudi parasites are able to proliferate faster early in infection when inoculated at lower numbers than when inoculated at high numbers.", "Febrile seizures increase the threshold for development of epilepsy.", "High-sensitivity cardiac troponin T (HSCT-T) dosage may not be diagnostic if the onset of symptoms occurs less than 3 hours before acute myocardial injury (AMI).", "Hypocretin neurones induce panicprone state in rats.", "Epidemiological disease burden from noncommunicable diseases is more prevalent in low economic settings.", "5% of perinatal mortality is due to low birth weight."], "hard_negatives": ["The composition of myosin-II isoform switches from the polarizable B isoform to the more homogenous A isoform during hematopoietic differentiation.", "Active H. pylori urease has a polymeric structure that compromises two subunits, UreA and UreB.", "During the primary early antibody response activated B cells migrate toward the inner-and outer paracortical areas where oxysterol accumulation is generated by stromal cells.", "Mutations in G-Beta protein GNB2 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.", "Deamination of cytidine to uridine on the minus strand of viral DNA results in catastrophic G-to-A mutations in the viral genome.", "PDPN promotes efficient motility along stromal surfaces by activating the C-type lectin receptor to rearrange the actin cytoskeleton in dendritic cells.", "Arginine 90 in p150n is important for interaction with EB1.", "The arm density of TatAd complexes is due to structural rearrangements within Class1 TatAd complexes such as the 'charge zipper mechanism'.", "Discrimination between the initiator and elongation tRNAs depends on the translation initiation factor IF3.", "The single flash-evoked ERG b-wave is generated by activity of ON-bipolar cells."], "hard_negative": "The composition of myosin-II isoform switches from the polarizable B isoform to the more homogenous A isoform during hematopoietic differentiation."}
{"query_id": "1213", "query_text": "The deregulated and prolonged activation of monocytes has deleterious effects in inflammatory diseases.", "negative": "Obesity decreases life quality.", "negatives": ["Obesity decreases life quality.", "PDPN promotes efficient motility along stromal surfaces by activating the C-type lectin receptor to rearrange the actin cytoskeleton in dendritic cells.", "MicroRNA is involved in the regulation of Neural Stem Cell (NSC) differentiation and proliferation dynamic homeostasis", "Bone marrow cells contribute to adult macrophage compartments.", "The minor G allele of FOXO3 is related to more severe symptoms of Crohn's Disease.", "Varenicline monotherapy is more effective after 12 weeks of treatment compared to combination nicotine replacement therapies with varenicline or bupropion.", "Vitamin D deficiency is unrelated to birth weight.", "Transferred UCB T cells acquire a memory-like phenotype in recipients.", "Ubiquitin ligase UBC13 generates a K63-linked polyubiquitin moiety at PCNA K164.", "Infection of human T-cell lymphotropic virus type 1 is most frequent in individuals of African origin."], "hard_negatives": ["The deregulated and prolonged activation of monocytes has deleterious effects in inflammatory diseases.", "PD-1 triggering on monocytes reduces IL-10 production by monocytes.", "AMP-activated protein kinase (AMPK) activation increases inflammation-related fibrosis in the lungs.", "Golli-deficient T-cells prefer to differentiate into an anergic phenotype in the adaptive immune response when there are increased levels of Ca2+ in the cytosol.", "Immune complex triggered cell death leads to extracellular release of neutrophil protein HMGB1.", "Ly6C hi monocytes have a lower inflammatory capacity compared to their Ly6C lo counterparts.", "Bone marrow cells contribute to adult macrophage compartments.", "Ly6C hi monocytes have a lower inflammatory capacity than Ly6C lo monocytes.", "Chronic aerobic exercise alters endothelial function, improving vasodilating mechanisms mediated by NO.", "Immune responses result in the development of inflammatory Th17 cells and anti-inflammatory iTregs."], "hard_negative": "The deregulated and prolonged activation of monocytes has deleterious effects in inflammatory diseases."}
{"query_id": "1216", "query_text": "The extracellular domain of TMEM27 is cleaved in human beta cells.", "negative": "Anthrax spores can be disposed of easily after they are dispersed.", "negatives": ["Anthrax spores can be disposed of easily after they are dispersed.", "New drugs for tuberculosis often do not penetrate the necrotic portion of a tuberculosis lesion in high concentrations.", "The genomic aberrations found in matasteses are very similar to those found in the primary tumor.", "Only a minority of cells survive development after differentiation into stress-resistant spores.", "UCB T cells maintain high TCR diversity after transplantation.", "Lymphadenopathy is observed in knockin mouse lacking the SHP-2 MAPK pathway.", "Glycolysis is one of the primary glycometabolic pathways in cells.", "Dexamethasone decreases risk of postoperative bleeding.", "Nanoparticles can be targeted against specific cell types by incorporating aptamers into lipid nanoparticles.", "There is an inverse relationship between hip fractures and statin use."], "hard_negatives": ["The extracellular domain of TMEM27 is cleaved in human beta cells.", "TNFAIP3 is a tumor suppressor in glioblastoma.", "Mutations in G-Beta protein GNB2 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.", "T regulatory cells (tTregs) lacking \u03b1v\u03b28 are more adept at suppressing pathogenic T-cell responses during active inflammation.", "CHEK2 is not associated with breast cancer.", "ITAM phosphorylation prevents the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).", "Bone marrow cells contribute to adult macrophage compartments.", "Pseudogene PTENP1 regulates the expression of PTEN by functioning as an miRNA decoy.", "Low expression of miR7a exerts a biological function in testis.", "CX3CR1 on the Th2 cells promotes T cell survival"], "hard_negative": "The extracellular domain of TMEM27 is cleaved in human beta cells."}
{"query_id": "1221", "query_text": "The genomic aberrations found in matasteses are very similar to those found in the primary tumor.", "negative": "Macropinocytosis contributes to a cell's supply of amino acids via the intracellular uptake of protein.", "negatives": ["Macropinocytosis contributes to a cell's supply of amino acids via the intracellular uptake of protein.", "Bariatric surgery has a positive impact on mental health.", "PD-1 triggering on monocytes reduces IL-10 production by monocytes.", "Increased microtubule acetylation repairs LRRK2 Roc-COR domain mutation induced locomotor deficits.", "Subcutaneous fat depots undergo extensive browning processes after cold exposure.", "The ureABIEFGH gene cluster is induced by nickel (II) ion.", "In young and middle-aged adults, current or remote uses of ADHD medications do not increase the risk of serious cardiovascular events.", "Localization of PIN1 in the roots of Arabidopsis does not require VPS9a", "There is no association between HNF4A mutations and diabetes risks.", "Mercaptopurine is anabolized into the inactive methylmercaptopurine by thiopurine methyltrasnferase (TPMT)."], "hard_negatives": ["The genomic aberrations found in matasteses are very similar to those found in the primary tumor.", "Flexible molecules experience greater steric hindrance in the tumor microenviroment than rigid molecules.", "Epigenetic modulating agents (EMAs) modulate antitumor immune response in a cancer model system.", "Silencing of Bcl2 is important for the maintenance and progression of tumors.", "Downregulation and mislocalization of Scribble prevents cell transformation and mammary tumorigenesis.", "Combining phosphatidylinositide 3-kinase and MEK 1/2 inhibitors is effective at treating KRAS mutant tumors.", "The loss of the TET protein functions may have dire biological consequences, such as myeloid cancers.", "The severity of cardiac involvement in amyloidosis can be described by the degree of transmurality of late gadolinium enhancement in MRI.", "PGE 2 promotes intestinal tumor growth by altering the expression of tumor suppressing and DNA repair genes.", "Increased vessel density along with a reduction in fibrosis decreases the efficacy of chemotherapy treatments."], "hard_negative": "The genomic aberrations found in matasteses are very similar to those found in the primary tumor."}
{"query_id": "1225", "query_text": "The locus rs647161 is associated with colorectal carcinoma.", "negative": "Mice without IFN-\u03b3 or its receptor are resistant to EAM induced with \u03b1-MyHC/CFA.", "negatives": ["Mice without IFN-\u03b3 or its receptor are resistant to EAM induced with \u03b1-MyHC/CFA.", "The loss of the TET protein functions may have dire biological consequences, such as myeloid cancers.", "During the primary early antibody response activated B cells migrate toward the inner-and outer paracortical areas where oxysterol accumulation is generated by stromal cells.", "Integrating classroom-based collaborative learning with Web-based collaborative learning leads to subpar class performance", "The single flash-evoked ERG b-wave is generated by activity of ON-bipolar cells.", "Homozygous deletion of murine Sbds gene from osterix-expressing mesenchymal stem and progenitor cells (MPCs) prevents oxidative stress.", "NF2 (Merlin) causes phosphorylation and subsequent cytoplasmic sequestration of YAP in Drosophila by activating LATS1/2 kinases.", "Rapamycin decreases the concentration of triacylglycerols in fruit flies.", "5% of perinatal mortality is due to low birth weight.", "Silencing of Bcl2 is important for the maintenance and progression of tumors."], "hard_negatives": ["The locus rs647161 is associated with colorectal carcinoma.", "Low expression of miR7a exerts a biological function in testis.", "TNFAIP3 is a tumor suppressor in glioblastoma.", "ALDH1 expression is associated with poorer prognosis in breast cancer.", "ALDH1 expression is associated with better breast cancer outcomes.", "Low expression of miR7a does represses target genes and exerts a biological function in ovaries.", "NR5A2 is important in development of endometrial tissues.", "N348I mutations cause resistance to zidovudine (AZT).", "The PPR MDA5 has two N-terminal CARD domains.", "ADAR1 binds to Dicer to cleave pre-miRNA."], "hard_negative": "The locus rs647161 is associated with colorectal carcinoma."}
{"query_id": "1226", "query_text": "The loss of the TET protein functions may have dire biological consequences, such as myeloid cancers.", "negative": "Bone marrow cells contribute to adult macrophage compartments.", "negatives": ["Bone marrow cells contribute to adult macrophage compartments.", "High cardiopulmonary fitness causes increased mortality rate.", "Occupancy of ribosomes by IncRNAs mirror 5 0-UTRs", "Increased microtubule acetylation repairs LRRK2 Roc-COR domain mutation induced locomotor deficits.", "IgA plasma cells that are specific for transglutaminase 2 accumulate in the duodenal mucosa on commencement of a gluten-free diet.", "Insulin increases risk of severe kidney failure.", "Primary pro-inflammatory cytokines induce secondary pro- and anti-inflammatory mediators.", "Non-invasive ventilation use should be decreased if there is inadequate response to conventional treatment.", "Deleting Raptor reduces G-CSF levels.", "Ultrasound guidance significantly raises the number of traumatic procedures when attempting needle insertion."], "hard_negatives": ["The loss of the TET protein functions may have dire biological consequences, such as myeloid cancers.", "Up-regulation of the p53 pathway and related molecular events casues cancer resistance and results in a significantly shortened lifespan marked by senescent cells and accelerated organismal aging.", "Pseudogene PTENP1 regulates the expression of PTEN by functioning as an miRNA decoy.", "The relationship between a breast cancer patient's capacity to metabolize tamoxifen and treatment outcome is dependent on the patient's genetic make-up.", "mTORC2 regulates intracellular cysteine levels through xCT inhibition.", "Nanoparticles can be targeted against specific cell types by incorporating aptamers into lipid nanoparticles.", "The genomic aberrations found in matasteses are very similar to those found in the primary tumor.", "ITAM phosphorylation prevents the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).", "Normal expression of RUNX1 has tumor-promoting effects.", "PGE 2 promotes intestinal tumor growth by altering the expression of tumor suppressing and DNA repair genes."], "hard_negative": "The loss of the TET protein functions may have dire biological consequences, such as myeloid cancers."}
{"query_id": "1232", "query_text": "The minor G allele of FOXO3 is related to more severe symptoms of Crohn's Disease.", "negative": "Downregulation and mislocalization of Scribble prevents cell transformation and mammary tumorigenesis.", "negatives": ["Downregulation and mislocalization of Scribble prevents cell transformation and mammary tumorigenesis.", "Antiretroviral therapy reduces rates of tuberculosis across a broad range of CD4 strata.", "Taxation of sugar-sweetened beverages had no effect on the incidence rate of type II diabetes in India.", "Occupancy of ribosomes by IncRNAs mirror 5 0-UTRs", "The extracellular domain of TMEM27 is cleaved in human beta cells.", "High dietary calcium intakes are unnecessary for prevention of secondary hyperparathyroidism in subjects with 25(OH)D levels above 75 nmol/liter.", "Auditory entrainment is strengthened when people see congruent visual and auditory information.", "Autologous transplantation of mesenchymal stem cells causes fewer opportunistic infections than induction therapy with anti-interleukin-2 receptor antibodies.", "Silencing of Bcl2 is important for the maintenance and progression of tumors.", "Lupus-prone mice infected with curliproducing bacteria have higher autoantibody titers compared to controls."], "hard_negatives": ["The minor G allele of FOXO3 is related to more severe symptoms of Crohn's Disease.", "FoxO3a activation in neuronal death is mediated by reactive oxygen species (ROS).", "Mutations in G-Beta protein GNB2 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.", "Mice that lack Interferon-\u03b3 or its receptor exhibit high resistance to experimental autoimmune myocarditis.", "Mice without IFN-\u03b3 or its receptor are resistant to EAM induced with \u03b1-MyHC/CFA.", "There is no association between HNF4A mutations and diabetes risks.", "HNF4A mutations can cause diabetes in mutant carriers by the age of 14 years", "Tetraspanin-3 is a causative factor in the development of acute myelogenous leukemia", "TNFAIP3 is a tumor suppressor in glioblastoma.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have increased risk for dementia."], "hard_negative": "The minor G allele of FOXO3 is related to more severe symptoms of Crohn's Disease."}
{"query_id": "1241", "query_text": "The myocardial lineage develops from cardiac progenitors of mesodermal origin.", "negative": "During the primary early antibody response activated B cells migrate toward the inner-and outer paracortical areas where oxysterol accumulation is generated by stromal cells.", "negatives": ["During the primary early antibody response activated B cells migrate toward the inner-and outer paracortical areas where oxysterol accumulation is generated by stromal cells.", "Transplanted human glial progenitor cells are incapable of forming a neural network with host animals' neurons.", "In transgenic mice harboring green florescent protein under the control of the Sox2 promoter, less than ten percent of the cells with green florescent colocalize with cell proliferation markers.", "Non-invasive ventilation use should be decreased if there is inadequate response to conventional treatment.", "Hyperfibrinogenemia decreases rates of femoropopliteal bypass thrombosis.", "PDPN promotes efficient motility along stromal surfaces by activating the C-type lectin receptor to rearrange the actin cytoskeleton in dendritic cells.", "p16INK4A accumulation is  linked to an abnormal wound response caused by the microinvasive step of advanced Oral Potentially Malignant Lesions (OPMLs).", "The minor G allele of FOXO3 is related to more severe symptoms of Crohn's Disease.", "The repair of Cas9-induced double strand breaks in human DNA is error-prone.", "Arterioles have a larger lumen diameter than venules."], "hard_negatives": ["The myocardial lineage develops from cardiac progenitors of mesodermal origin.", "The severity of cardiac involvement in amyloidosis can be described by the degree of transmurality of late gadolinium enhancement in MRI.", "CRP is not predictive of postoperative mortality following Coronary Artery Bypass Graft (CABG) surgery.", "Bone marrow cells contribute to adult macrophage compartments.", "All hematopoietic stem cells segregate their chromosomes randomly.", "Functional consequences of genomic alterations due to Myelodysplastic syndrome (MDS) are poorly understood due to the lack of an animal model.", "Modifying the epigenome in the brain affects the normal human aging process by affecting certain genes related to neurogenesis.", "Macrolides have no protective effect against myocardial infarction.", "Macrolides protect against myocardial infarction.", "GATA-3 is important for hematopoietic stem cell (HSC) function."], "hard_negative": "The myocardial lineage develops from cardiac progenitors of mesodermal origin."}
{"query_id": "1245", "query_text": "The one-child policy has been successful in lowering population growth.", "negative": "CX3CR1 on the Th2 cells promotes airway inflammation.", "negatives": ["CX3CR1 on the Th2 cells promotes airway inflammation.", "During the primary early antibody response activated B cells migrate toward the inner-and outer paracortical areas where oxysterol accumulation is generated by stromal cells.", "Mutations in G-Beta protein GNB2 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.", "The benefits of colchicine were achieved with effective widespread use of secondary prevention strategies such as high-dose statins.", "Bariatric surgery has a positive impact on mental health.", "The ureABIEFGH gene cluster is induced by nickel (II) ion.", "Upregulation of mosGCTL-1 is induced upon infection with West Nile virus.", "Enhanced early production of inflammatory chemokines improves viral control in the lung.", "Occupancy of ribosomes by IncRNAs mirror 5 0-UTRs", "Transplanted human glial cells can differentiate within the host animal."], "hard_negatives": ["The one-child policy has been successful in lowering population growth.", "5% of perinatal mortality is due to low birth weight.", "The availability of safe places to study is not effective at decreasing homelessness.", "The availability of safe places to study is effective at decreasing homelessness.", "Birth-weight is positively associated with breast cancer.", "The amount of publicly available DNA data doubles every 10 years.", "Women with a higher birth weight are more likely to develop breast cancer later in life.", "Incidence rates of cervical cancer have decreased.", "Patients in stable partnerships have a faster progression from HIV to AIDS.", "Vitamin D deficiency is unrelated to birth weight."], "hard_negative": "The one-child policy has been successful in lowering population growth."}
{"query_id": "1259", "query_text": "The relationship between a breast cancer patient's capacity to metabolize tamoxifen and treatment outcome is dependent on the patient's genetic make-up.", "negative": "Inositol lipid 3-phosphatase PTEN converts Ptdlns(3,4)P 2 into phosphatidylinositol 4-phosphate.", "negatives": ["Inositol lipid 3-phosphatase PTEN converts Ptdlns(3,4)P 2 into phosphatidylinositol 4-phosphate.", "Functional consequences of genomic alterations due to Myelodysplastic syndrome (MDS) are poorly understood due to the lack of an animal model.", "Podocytes are motile and migrate in the presence of injury.", "Glycolysis is one of the primary glycometabolic pathways in cells.", "Infection of human T-cell lymphotropic virus type 1 is most frequent in individuals of African origin.", "Hypertension is frequently observed in type 1 diabetes patients.", "High cardiopulmonary fitness causes increased mortality rate.", "Active H. pylori urease has a polymeric structure that compromises two subunits, UreA and UreB.", "Leukemia associated Rho guanine nucleotide-exchange factor represses RhoA in response to SRC activation.", "Antibiotic induced alterations in the gut microbiome reduce resistance against Clostridium difficile"], "hard_negatives": ["The relationship between a breast cancer patient's capacity to metabolize tamoxifen and treatment outcome is dependent on the patient's genetic make-up.", "The risk of breast cancer among parous women increases with placental weight of pregnancies, and this association is strongest for premenopausal breast cancer.", "Breast cancer development is determined exclusively by genetic factors.", "Sildenafil improves erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.", "Metastatic colorectal cancer treated with a single agent fluoropyrimidines resulted in reduced efficacy and lower quality of life when compared with oxaliplatin-based chemotherapy in elderly patients.", "Epigenetic modulating agents (EMAs) modulate antitumor immune response in a cancer model system.", "Stroke patients with prior use of direct oral anticoagulants have a lower risk of in-hospital mortality than stroke patients with prior use of warfarin.", "Monoclonal antibody targeting of N-cadherin inhibits metastasis.", "Women with a higher birth weight are more likely to develop breast cancer later in life.", "Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have a dramatic impact in reducing malaria transmission."], "hard_negative": "The relationship between a breast cancer patient's capacity to metabolize tamoxifen and treatment outcome is dependent on the patient's genetic make-up."}
{"query_id": "1262", "query_text": "The repair of Cas9-induced double strand breaks in human DNA is error-prone.", "negative": "Pretreatment with the Arp2/3 inhibitor CK-666 affects lamelliopodia formation.", "negatives": ["Pretreatment with the Arp2/3 inhibitor CK-666 affects lamelliopodia formation.", "Only a minority of cells survive development after differentiation into stress-resistant spores.", "Stroke patients with prior use of direct oral anticoagulants have a lower risk of in-hospital mortality than stroke patients with prior use of warfarin.", "The treatment of cancer patients with co-IR blockade does not cause any adverse autoimmune events.", "Ly49Q directs the organization of neutrophil migration to inflammation sites by regulating membrane raft functions.", "Anthrax spores can be disposed of easily after they are dispersed.", "Autologous transplantation of mesenchymal stem cells causes fewer opportunistic infections than induction therapy with anti-interleukin-2 receptor antibodies.", "Carriers of the alcohol aldehyde dehydrogenase deficiency mutation drink less that non-carries.", "Macropinocytosis contributes to a cell's supply of amino acids via the intracellular uptake of protein.", "Pseudogene PTENP1 regulates the expression of PTEN by functioning as an miRNA decoy."], "hard_negatives": ["The repair of Cas9-induced double strand breaks in human DNA is error-prone.", "Most termination events in Okazaki fragments are sequence specific.", "Free histones are degraded by a Rad53-dependent mechanism once DNA has been replicated.", "IFIT1 restricts viral replication by sequestrating mis-capped viral RNAs.", "Functional consequences of genomic alterations due to Myelodysplastic syndrome (MDS) are poorly understood due to the lack of an animal model.", "Localization of PIN1 in the Arabidopsis embryo does not require VPS9a", "Low nucleosome occupancy correlates with low methylation levels across species.", "Mice defective for deoxyribonucleic acid (DNA) polymerase I (polI) reveal increased sensitivity to ionizing radiation (IR).", "Deamination of cytidine to uridine on the minus strand of viral DNA results in catastrophic G-to-A mutations in the viral genome.", "N348I mutations cause resistance to zidovudine (AZT)."], "hard_negative": "The repair of Cas9-induced double strand breaks in human DNA is error-prone."}
{"query_id": "1266", "query_text": "The risk of breast cancer among parous women increases with placental weight of pregnancies, and this association is strongest for premenopausal breast cancer.", "negative": "The treatment of cancer patients with co-IR blockade precipitates adverse autoimmune events.", "negatives": ["The treatment of cancer patients with co-IR blockade precipitates adverse autoimmune events.", "Gene expression does not vary appreciably across genetically identical cells.", "aPKCz causes tumour enhancement by affecting glutamine metabolism.", "Increased vessel density along with a reduction in fibrosis decreases the efficacy of chemotherapy treatments.", "IFIT1 restricts viral replication by sequestrating mis-capped viral RNAs.", "1,000 genomes project enables mapping of genetic sequence variation consisting of rare variants with larger penetrance effects than common variants.", "Transplanted human glial cells can differentiate within the host animal.", "Taxation of sugar-sweetened beverages had no effect on the incidence rate of type II diabetes in India.", "Increased microtubule acetylation repairs LRRK2 Roc-COR domain mutation induced locomotor deficits.", "Hypertension is frequently observed in type 1 diabetes patients."], "hard_negatives": ["The risk of breast cancer among parous women increases with placental weight of pregnancies, and this association is strongest for premenopausal breast cancer.", "Women with a higher birth weight are more likely to develop breast cancer later in life.", "Birth-weight is positively associated with breast cancer.", "Breast cancer development is determined exclusively by genetic factors.", "Incidence rates of cervical cancer have increased due to nationwide screening programs based primarily on cytology to detect uterine cervical cancer.", "The relationship between a breast cancer patient's capacity to metabolize tamoxifen and treatment outcome is dependent on the patient's genetic make-up.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have increased risk for dementia.", "Incidence rates of cervical cancer have decreased.", "Sildenafil improves erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.", "5% of perinatal mortality is due to low birth weight."], "hard_negative": "The risk of breast cancer among parous women increases with placental weight of pregnancies, and this association is strongest for premenopausal breast cancer."}
{"query_id": "1270", "query_text": "The risk of male prisoners harming themselves is ten times that of female prisoners.", "negative": "NF2 (Merlin) prevents phosphorylation and subsequent cytoplasmic sequestration of YAP in Drosophila.", "negatives": ["NF2 (Merlin) prevents phosphorylation and subsequent cytoplasmic sequestration of YAP in Drosophila.", "The treatment of cancer patients with co-IR blockade precipitates adverse autoimmune events.", "High cardiopulmonary fitness causes increased mortality rate.", "The PRR MDA5 has a central DExD/H RNA helices domain.", "Venules have a larger lumen diameter than arterioles.", "Articles published in open access format are more likely to be cited than traditional journals.", "Thigh-length graduated compression stockings (GCS) did not reduce deep vein thrombosis in patients admitted to hospital who are immobile because of acute stroke.", "Primary cervical cancer screening with HPV detection has higher longitudinal sensitivity than conventional cytology to detect cervical intraepithelial neoplasia grade 2.", "NOX2-independent pathways can generate peroxynitrite by reacting with nitrogen intermediates.", "Crosstalk between dendritic cells (DCs) and innate lymphoid cells (ILCs) is important in the regulation of intestinal homeostasis."], "hard_negatives": ["The risk of male prisoners harming themselves is ten times that of female prisoners.", "Sildenafil improves erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.", "The availability of safe places to study is not effective at decreasing homelessness.", "5% of perinatal mortality is due to low birth weight.", "The availability of safe places to study is effective at decreasing homelessness.", "Input from  mental and physical health care professionals is effective at decreasing homelessness.", "Incidence of heart failure decreased by 10% in women since 1979.", "HNF4A mutations can cause diabetes in mutant carriers by the age of 14 years", "Less than 10% of the gabonese children with Schimmelpenning-Feuerstein-Mims syndrome (SFM) had a plasma lactate of more than 5mmol/L.", "Combination nicotine replacement therapies with varenicline or bupropion lead to significantly higher long-term abstinence rates at 52 weeks than varenicline monotherapy."], "hard_negative": "The risk of male prisoners harming themselves is ten times that of female prisoners."}
{"query_id": "1271", "query_text": "The severity of cardiac involvement in amyloidosis can be described by the degree of transmurality of late gadolinium enhancement in MRI.", "negative": "The severity of cardiac involvement in amyloidosis can be described by the degree of transmurality of late gadolinium enhancement in MRI.", "negatives": ["The severity of cardiac involvement in amyloidosis can be described by the degree of transmurality of late gadolinium enhancement in MRI.", "Articles published in open access format are more likely to be cited than traditional journals.", "The locus rs647161 is associated with colorectal carcinoma.", "Omnivores produce less trimethylamine N-oxide from dietary I-carnitine than vegetarians.", "Hyperfibrinogenemia increases rates of femoropopliteal bypass thrombosis.", "The myocardial lineage develops from cardiac progenitors of mesodermal origin.", "CCL19 is absent within dLNs.", "The treatment of cancer patients with co-IR blockade does not cause any adverse autoimmune events.", "Immune complex triggered cell death leads to extracellular release of neutrophil protein HMGB1.", "The deregulated and prolonged activation of monocytes has deleterious effects in inflammatory diseases."], "hard_negatives": ["The severity of cardiac involvement in amyloidosis can be described by the degree of transmurality of late gadolinium enhancement in MRI.", "Functional consequences of genomic alterations due to Myelodysplastic syndrome (MDS) are poorly understood due to the lack of an animal model.", "CRP is not predictive of postoperative mortality following Coronary Artery Bypass Graft (CABG) surgery.", "The myocardial lineage develops from cardiac progenitors of mesodermal origin.", "High-sensitivity cardiac troponin T (HSCT-T) dosage may not be diagnostic if the onset of symptoms occurs less than 3 hours before acute myocardial injury (AMI).", "Diabetic patients with acute coronary syndrome experience increased short-term and long-term risk for bleeding events.", "Angiotensin converting enzyme inhibitors are associated with increased risk for functional renal insufficiency.", "Silencing of Bcl2 is important for the maintenance and progression of tumors.", "Chronic aerobic exercise alters endothelial function, improving vasodilating mechanisms mediated by NO.", "A deficiency of vitamin B12 increases blood levels of homocysteine."], "hard_negative": "The severity of cardiac involvement in amyloidosis can be described by the degree of transmurality of late gadolinium enhancement in MRI."}
{"query_id": "1272", "query_text": "The single flash-evoked ERG b-wave is generated by activity of ON-bipolar cells.", "negative": "The extracellular domain of TMEM27 is cleaved in human beta cells.", "negatives": ["The extracellular domain of TMEM27 is cleaved in human beta cells.", "Taking 400mg of \u03b1-tocopheryl acetate helps to prevent prostate cancer.", "Blocking the interaction between TDP-43 and respiratory complex I proteins ND3 and ND6 leads to increased TDP-43-induced neuronal loss.", "PKG-la plays an essential role in expression of pain hypersensitivity in PGK-la knockout mice.", "Articles published in open access format are less likely to be cited than traditional journals.", "Activator-inhibitor pairs are provided dorsally by Admpchordin.", "Up-regulation of the p53 pathway and related molecular events casues cancer resistance and results in a significantly shortened lifespan marked by senescent cells and accelerated organismal aging.", "De novo assembly of sequence data has more specific contigs than unassembled sequence data.", "The benefits of colchicine were achieved with effective widespread use of secondary prevention strategies such as high-dose statins.", "Only a minority of cells survive development after differentiation into stress-resistant spores."], "hard_negatives": ["The single flash-evoked ERG b-wave is generated by activity of ON-bipolar cells.", "During the primary early antibody response activated B cells migrate toward the inner-and outer paracortical areas where oxysterol accumulation is generated by stromal cells.", "The sliding activity of kinesin-8 protein Kip3 promotes bipolar spindle assembly.", "Assembly of invadopodia is triggered by focal generation of phosphatidylinositol-3,4-biphosphate and the activation of the nonreceptor tyrosine kinase Src.", "ITAM phosphorylation prevents the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).", "IRG1 has antiviral effects against neurotropic viruses.", "PD-1 triggering on monocytes reduces IL-10 production by monocytes.", "Hypocretin neurones induce panicprone state in rats.", "Immune complex triggered cell death leads to extracellular release of neutrophil protein HMGB1.", "Transferred UCB T cells acquire a memory-like phenotype in recipients."], "hard_negative": "The single flash-evoked ERG b-wave is generated by activity of ON-bipolar cells."}
{"query_id": "1273", "query_text": "The sliding activity of kinesin-8 protein Kip3 promotes bipolar spindle assembly.", "negative": "The ureABIEFGH gene cluster is induced by nickel (II) ion.", "negatives": ["The ureABIEFGH gene cluster is induced by nickel (II) ion.", "The US health care system can save up to $750 million if 7% of patients waiting for kidney transplants participate in the optimized national kidney paired donation program.", "NF2 (Merlin) prevents phosphorylation and subsequent cytoplasmic sequestration of YAP in Drosophila.", "Arterioles have a larger lumen diameter than venules.", "Sildenafil improves erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.", "Hypothalamic glutamate neurotransmission is crucial to energy balance.", "PGE 2 promotes intestinal tumor growth by altering the expression of tumor suppressing and DNA repair genes.", "ALDH1 expression is associated with better breast cancer outcomes.", "Occupancy of ribosomes by IncRNAs mirror 5 0-UTRs", "Mutant mice lacking SVCT2 have greatly increased ascorbic acid levels in both brain and adrenals."], "hard_negatives": ["The sliding activity of kinesin-8 protein Kip3 promotes bipolar spindle assembly.", "Pyridostatin destabilizes the G - quadruplex in the telomeric region.", "The single flash-evoked ERG b-wave is generated by activity of ON-bipolar cells.", "The arm density of TatAd complexes is due to structural rearrangements within Class1 TatAd complexes such as the 'charge zipper mechanism'.", "Smc5/6 engagment drives the activation of SUMO E3 ligase Mms21 by ATP-dependent remolding.", "Ubiquitin ligase UBC13 generates a K63-linked polyubiquitin moiety at PCNA K164.", "Assembly of invadopodia is triggered by focal generation of phosphatidylinositol-3,4-biphosphate and the activation of the nonreceptor tyrosine kinase Src.", "PDPN promotes efficient motility along stromal surfaces by activating the C-type lectin receptor to rearrange the actin cytoskeleton in dendritic cells.", "Activator-inhibitor pairs are provided dorsally by Admpchordin.", "Fz/PCP-dependent Pk localizes to the anterior membrane of neuroectoderm cells during zebrafish neuralation"], "hard_negative": "The sliding activity of kinesin-8 protein Kip3 promotes bipolar spindle assembly."}
{"query_id": "1274", "query_text": "The tip of the inner tube of the toxic type VI secretion system (T6SS) antibacterial effector in Escherichia coli (E. coli) carries toxic effector proteins.", "negative": "TNFAIP3 is a tumor suppressor in glioblastoma.", "negatives": ["TNFAIP3 is a tumor suppressor in glioblastoma.", "ADAR1 binds to Dicer to cleave pre-miRNA.", "Peroxynitrite is required for nitration of TCR/CD8.", "Headaches are not correlated with cognitive impairment.", "CX3CR1 on the Th2 cells promotes airway inflammation.", "Cold exposure reduces BAT recruitment.", "Crossover hot spots are not found within gene promoters in Saccharomyces cerevisiae.", "The loss of the TET protein functions may have dire biological consequences, such as myeloid cancers.", "All hematopoietic stem cells segregate their chromosomes randomly.", "FoxO3a activation in neuronal death is mediated by reactive oxygen species (ROS)."], "hard_negatives": ["The tip of the inner tube of the toxic type VI secretion system (T6SS) antibacterial effector in Escherichia coli (E. coli) carries toxic effector proteins.", "During the primary early antibody response activated B cells migrate toward the inner-and outer paracortical areas where oxysterol accumulation is generated by stromal cells.", "Activator-inhibitor pairs are provided dorsally by Admpchordin.", "The center of the granuloma in an immune cell induces a pro-inflammatory immune response.", "The PRR MDA5 has a central DExD/H RNA helices domain.", "Active H. pylori urease has a polymeric structure that compromises two subunits, UreA and UreB.", "Antibiotic induced alterations in the gut microbiome reduce resistance against Clostridium difficile", "Crosstalk between dendritic cells (DCs) and innate lymphoid cells (ILCs) is important in the regulation of intestinal homeostasis.", "New drugs for tuberculosis often do not penetrate the necrotic portion of a tuberculosis lesion in high concentrations.", "PDPN promotes efficient motility along stromal surfaces by activating the C-type lectin receptor to rearrange the actin cytoskeleton in dendritic cells."], "hard_negative": "The tip of the inner tube of the toxic type VI secretion system (T6SS) antibacterial effector in Escherichia coli (E. coli) carries toxic effector proteins."}
{"query_id": "1278", "query_text": "The treatment of cancer patients with co-IR blockade does not cause any adverse autoimmune events.", "negative": "Occupancy of ribosomes by IncRNAs mirror 5 0-UTRs", "negatives": ["Occupancy of ribosomes by IncRNAs mirror 5 0-UTRs", "Ultrasound guidance significantly raises the number of traumatic procedures when attempting needle insertion.", "Arterioles have a larger lumen diameter than venules.", "Anthrax spores can be disposed of easily after they are dispersed.", "Patients in stable partnerships have a faster progression from HIV to AIDS.", "Lupus-prone mice infected with curliproducing bacteria have higher autoantibody titers compared to controls.", "Human T-lymphotropic virus type-I-associated myelopathy / tropical spastic paraparesis (HAM/TSP) patients produce Immunoglobulin G (IgG) antibodies which cross-react with an immunodominant epitope in Tax.", "1,000 genomes project enables mapping of genetic sequence variation consisting of rare variants with larger penetrance effects than common variants.", "CCL19 is absent within dLNs.", "Cell autonomous sex determination in somatic cells occurs in Passeriformes."], "hard_negatives": ["The treatment of cancer patients with co-IR blockade does not cause any adverse autoimmune events.", "The treatment of cancer patients with co-IR blockade precipitates adverse autoimmune events.", "Mice that lack Interferon-\u03b3 or its receptor exhibit high resistance to experimental autoimmune myocarditis.", "Stroke patients with prior use of direct oral anticoagulants have a lower risk of in-hospital mortality than stroke patients with prior use of warfarin.", "Epigenetic modulating agents (EMAs) modulate antitumor immune response in a cancer model system.", "Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have a dramatic impact in reducing malaria transmission.", "Metastatic colorectal cancer treated with a single agent fluoropyrimidines resulted in reduced efficacy and lower quality of life when compared with oxaliplatin-based chemotherapy in elderly patients.", "IRG1 has antiviral effects against neurotropic viruses.", "Mice without IFN-\u03b3 or its receptor are resistant to EAM induced with \u03b1-MyHC/CFA.", "Reduced responsiveness to interleukin-2 in regulatory T cells is associated with greater resistance to autoimmune diseases such as Type 1 Diabetes."], "hard_negative": "The treatment of cancer patients with co-IR blockade does not cause any adverse autoimmune events."}
{"query_id": "1279", "query_text": "The treatment of cancer patients with co-IR blockade precipitates adverse autoimmune events.", "negative": "Deamination of cytidine to uridine on the minus strand of viral DNA results in catastrophic G-to-A mutations in the viral genome.", "negatives": ["Deamination of cytidine to uridine on the minus strand of viral DNA results in catastrophic G-to-A mutations in the viral genome.", "The extracellular domain of TMEM27 is cleaved in human beta cells.", "Venules have a larger lumen diameter than arterioles.", "Ethanol stress decreases the expression of IBP in bacteria.", "TNFAIP3 is a tumor suppressor in glioblastoma.", "Mitochondria are uninvolved in apoptosis.", "The loss of the TET protein functions may have dire biological consequences, such as myeloid cancers.", "Microarray results from culture-amplified mixtures of serotypes correlate poorly with microarray results from uncultured mixtures.", "Neutrophil extracellular traps (NETs) are released by ANCA-stimulated neutrophils.", "Statins increase blood cholesterol."], "hard_negatives": ["The treatment of cancer patients with co-IR blockade precipitates adverse autoimmune events.", "The treatment of cancer patients with co-IR blockade does not cause any adverse autoimmune events.", "Mice that lack Interferon-\u03b3 or its receptor exhibit high resistance to experimental autoimmune myocarditis.", "Stroke patients with prior use of direct oral anticoagulants have a lower risk of in-hospital mortality than stroke patients with prior use of warfarin.", "Epigenetic modulating agents (EMAs) modulate antitumor immune response in a cancer model system.", "Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have a dramatic impact in reducing malaria transmission.", "Metastatic colorectal cancer treated with a single agent fluoropyrimidines resulted in reduced efficacy and lower quality of life when compared with oxaliplatin-based chemotherapy in elderly patients.", "IRG1 has antiviral effects against neurotropic viruses.", "Mice without IFN-\u03b3 or its receptor are resistant to EAM induced with \u03b1-MyHC/CFA.", "Reduced responsiveness to interleukin-2 in regulatory T cells is associated with greater resistance to autoimmune diseases such as Type 1 Diabetes."], "hard_negative": "The treatment of cancer patients with co-IR blockade precipitates adverse autoimmune events."}
{"query_id": "1280", "query_text": "The ureABIEFGH gene cluster encodes urease maturation proteins : UreD/UreH, UreE, UreF, and UreG.", "negative": "Statins decrease blood cholesterol.", "negatives": ["Statins decrease blood cholesterol.", "A high microerythrocyte count raises vulnerability to severe anemia in homozygous alpha (+)- thalassemia trait subjects.", "Autologous transplantation of mesenchymal stem cells causes a higher rate of opportunistic infections than induction therapy with anti-interleukin-2 receptor antibodies.", "Occupancy of ribosomes by IncRNAs do not make functional peptides.", "CCL19 is absent within dLNs.", "Insomnia can be effectively treated with cognitive behavioral therapy.", "Combination nicotine replacement therapies with varenicline or bupropion lead to significantly higher long-term abstinence rates at 52 weeks than varenicline monotherapy.", "In transgenic mice harboring green florescent protein under the control of the Sox2 promoter, less than ten percent of the cells with green florescent colocalize with cell proliferation markers.", "Vitamin D deficiency is unrelated to birth weight.", "Cellular aging closely links to an older appearance."], "hard_negatives": ["The ureABIEFGH gene cluster encodes urease maturation proteins : UreD/UreH, UreE, UreF, and UreG.", "Active H. pylori urease has a polymeric structure that compromises two subunits, UreA and UreB.", "The ureABIEFGH gene cluster is induced by nickel (II) ion.", "Occupancy of ribosomes by IncRNAs mirror 5 0-UTRs", "Crossover hot spots are not found within gene promoters in Saccharomyces cerevisiae.", "The PPR MDA5 has two N-terminal CARD domains.", "DMRT1 is a sex-determining gene that is epigenetically regulated by the MHM region.", "Alizarin forms hydrogen bonds with residues involved in PGAM1 substrate binding.", "Commelina yellow mottle virus' (ComYMV) genome consists of 7489 baise pairs.", "Ly49Q directs the organization of neutrophil migration to inflammation sites by regulating membrane raft functions."], "hard_negative": "The ureABIEFGH gene cluster encodes urease maturation proteins : UreD/UreH, UreE, UreF, and UreG."}
{"query_id": "1281", "query_text": "The ureABIEFGH gene cluster is induced by nickel (II) ion.", "negative": "The extracellular domain of TMEM27 is cleaved in human beta cells.", "negatives": ["The extracellular domain of TMEM27 is cleaved in human beta cells.", "Less than 10% of the gabonese children with Schimmelpenning-Feuerstein-Mims syndrome (SFM) had a plasma lactate of more than 5mmol/L.", "Therapeutic use of the drug Dapsone to treat pyoderma gangrenous is based on anecdotal evidence.", "NF2 (Merlin) causes phosphorylation and subsequent cytoplasmic sequestration of YAP in Drosophila by activating LATS1/2 kinases.", "Taxation of sugar-sweetened beverages had no effect on the incidence rate of type II diabetes in India.", "The availability of safe places to study is effective at decreasing homelessness.", "The PRR MDA5 has a central DExD/H RNA helices domain.", "The PRR MDA5 has a central DExD/H RNA helices domain.", "PPAR-RXRs are inhibited by PPAR ligands.", "Immune responses result in the development of inflammatory Th17 cells and anti-inflammatory iTregs."], "hard_negatives": ["The ureABIEFGH gene cluster is induced by nickel (II) ion.", "The ureABIEFGH gene cluster encodes urease maturation proteins : UreD/UreH, UreE, UreF, and UreG.", "Active H. pylori urease has a polymeric structure that compromises two subunits, UreA and UreB.", "Mutations in G-Beta protein GNB2 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.", "Arginine 90 in p150n is important for interaction with EB1.", "The arm density of TatAd complexes is due to structural rearrangements within Class1 TatAd complexes such as the 'charge zipper mechanism'.", "NOX2-independent pathways can generate peroxynitrite by reacting with nitrogen intermediates.", "Cytosolic proteins bind to iron-responsive elements on mRNAs coding for DMT1. Cytosolic proteins bind to iron-responsive elements on mRNAs coding for proteins involved in iron uptake.", "Replacement of histone H2A with H2A.Z slows gene activation in yeasts by stabilizing +1 nucleosomes.", "N348I mutations cause resistance to zidovudine (AZT)."], "hard_negative": "The ureABIEFGH gene cluster is induced by nickel (II) ion."}
{"query_id": "1282", "query_text": "Therapeutic use of the drug Dapsone to treat pyoderma gangrenous is based on anecdotal evidence.", "negative": "Recurrent mutations occur frequently within CTCF anchor sites adjacent to oncogenes.", "negatives": ["Recurrent mutations occur frequently within CTCF anchor sites adjacent to oncogenes.", "Replacement of histone H2A with H2A.Z slows gene activation in yeasts by stabilizing +1 nucleosomes.", "Many proteins in human cells can be post-translationally modified at lysine residues via acetylation.", "cSMAC formation enhances weak ligand signalling.", "Mutations in G-Beta protein GNB2 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.", "T regulatory cells (tTregs) lacking \u03b1v\u03b28 are more adept at suppressing pathogenic T-cell responses during active inflammation.", "Activator-inhibitor pairs are provided dorsally by Admpchordin.", "A high microerythrocyte count raises vulnerability to severe anemia in homozygous alpha (+)- thalassemia trait subjects.", "All hematopoietic stem cells segregate their chromosomes randomly.", "The PRR MDA5 is a sensor of RNA virus infection."], "hard_negatives": ["Therapeutic use of the drug Dapsone to treat pyoderma gangrenous is based on anecdotal evidence.", "Epigenetic modulating agents (EMAs) modulate antitumor immune response in a cancer model system.", "Albendazole is used to treat lymphatic filariasis.", "Metastatic colorectal cancer treated with a single agent fluoropyrimidines resulted in reduced efficacy and lower quality of life when compared with oxaliplatin-based chemotherapy in elderly patients.", "The relationship between a breast cancer patient's capacity to metabolize tamoxifen and treatment outcome is dependent on the patient's genetic make-up.", "Varenicline monotherapy is more effective after 12 weeks of treatment compared to combination nicotine replacement therapies with varenicline or bupropion.", "Tetraspanin-3 is a causative factor in the development of acute myelogenous leukemia", "Functional consequences of genomic alterations due to Myelodysplastic syndrome (MDS) are poorly understood due to the lack of an animal model.", "Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have a dramatic impact in reducing malaria transmission.", "Ivermectin is used to treat lymphatic filariasis."], "hard_negative": "Therapeutic use of the drug Dapsone to treat pyoderma gangrenous is based on anecdotal evidence."}
{"query_id": "1290", "query_text": "There is an inverse relationship between hip fractures and statin use.", "negative": "Hematopoietic Stem Cell purification reaches purity rate of up to 50%.", "negatives": ["Hematopoietic Stem Cell purification reaches purity rate of up to 50%.", "New drugs for tuberculosis often do not penetrate the necrotic portion of a tuberculosis lesion in high concentrations.", "CX3CR1 on the Th2 cells impairs T cell survival", "Crosstalk between dendritic cells (DCs) and innate lymphoid cells (ILCs) is important in the regulation of intestinal homeostasis.", "Ly6C hi monocytes have a lower inflammatory capacity compared to their Ly6C lo counterparts.", "In adult tissue, most T cells are memory T cells.", "Omnivores produce less trimethylamine N-oxide from dietary I-carnitine than vegetarians.", "Mutations in G-Beta protein GNB2 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.", "0-dimensional biomaterials show inductive properties.", "The US health care system can save up to $750 million if 7% of patients waiting for kidney transplants participate in the optimized national kidney paired donation program."], "hard_negatives": ["There is an inverse relationship between hip fractures and statin use.", "Sildenafil improves erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.", "Bariatric surgery has a positive impact on mental health.", "Headaches are not correlated with cognitive impairment.", "In young and middle-aged adults, current or remote uses of ADHD medications do not increase the risk of serious cardiovascular events.", "The severity of cardiac involvement in amyloidosis can be described by the degree of transmurality of late gadolinium enhancement in MRI.", "Ultrasound guidance significantly raises the number of traumatic procedures when attempting needle insertion.", "Combination nicotine replacement therapies with varenicline or bupropion lead to significantly higher long-term abstinence rates at 52 weeks than varenicline monotherapy.", "High-sensitivity cardiac troponin T (HSCT-T) dosage may not be diagnostic if the onset of symptoms occurs less than 3 hours before acute myocardial injury (AMI).", "Dexamethasone decreases risk of postoperative bleeding."], "hard_negative": "There is an inverse relationship between hip fractures and statin use."}
{"query_id": "1292", "query_text": "There is no association between HNF4A mutations and diabetes risks.", "negative": "Autophagy declines in aged organisms.", "negatives": ["Autophagy declines in aged organisms.", "Incidence rates of cervical cancer have decreased.", "Up-regulation of the p53 pathway and related molecular events casues cancer resistance and results in a significantly shortened lifespan marked by senescent cells and accelerated organismal aging.", "Smc5/6 engagment drives the activation of SUMO E3 ligase Mms21 by ATP-dependent remolding.", "aPKCz causes tumour enhancement by affecting glutamine metabolism.", "N-terminal cleavage increases success identifying transcription start sites.", "The ureABIEFGH gene cluster is induced by nickel (II) ion.", "Monoclonal antibody targeting of N-cadherin inhibits metastasis.", "De novo assembly of sequence data has more specific contigs than unassembled sequence data.", "Tirasemtiv has no effect on fast-twitch muscle."], "hard_negatives": ["There is no association between HNF4A mutations and diabetes risks.", "HNF4A mutations can cause diabetes in mutant carriers by the age of 14 years", "A deficiency of vitamin B12 increases blood levels of homocysteine.", "Carriers of the alcohol aldehyde dehydrogenase deficiency mutation drink less that non-carries.", "Diabetic patients with acute coronary syndrome experience increased short-term and long-term risk for bleeding events.", "Mutations in G-Beta protein GNB2 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.", "Hypertension is frequently observed in type 1 diabetes patients.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have increased risk for dementia.", "Vitamin D deficiency is unrelated to birth weight.", "Functional consequences of genomic alterations due to Myelodysplastic syndrome (MDS) are poorly understood due to the lack of an animal model."], "hard_negative": "There is no association between HNF4A mutations and diabetes risks."}
{"query_id": "1298", "query_text": "Thigh-length graduated compression stockings (GCS) did not reduce deep vein thrombosis in patients admitted to hospital who are immobile because of acute stroke.", "negative": "Taxation of sugar-sweetened beverages had no effect on the incidence rate of type II diabetes in India.", "negatives": ["Taxation of sugar-sweetened beverages had no effect on the incidence rate of type II diabetes in India.", "Therapeutic use of the drug Dapsone to treat pyoderma gangrenous is based on anecdotal evidence.", "Febrile seizures reduce the threshold for development of epilepsy.", "Articles published in open access format are more likely to be cited than traditional journals.", "N-terminal cleavage increases success identifying transcription start sites.", "Individuals with low serum vitamin D concentrations have increased risk of multiple sclerosis.", "Normal expression of RUNX1 has tumor-promoting effects.", "Tetraspanin-3 is a causative factor in the development of acute myelogenous leukemia", "Peroxynitrite is required for nitration of TCR/CD8.", "Headaches are not correlated with cognitive impairment."], "hard_negatives": ["Thigh-length graduated compression stockings (GCS) did not reduce deep vein thrombosis in patients admitted to hospital who are immobile because of acute stroke.", "CRP is not predictive of postoperative mortality following Coronary Artery Bypass Graft (CABG) surgery.", "Hyperfibrinogenemia decreases rates of femoropopliteal bypass thrombosis.", "Bariatric surgery has a positive impact on mental health.", "Hyperfibrinogenemia increases rates of femoropopliteal bypass thrombosis.", "Hypertension is frequently observed in type 1 diabetes patients.", "High levels of CRP reduces the risk of exacerbations in chronic obstructive pulmonary disease (COPD).", "Basophils counteract disease development in patients with systemic lupus erythematosus (SLE).", "There is an inverse relationship between hip fractures and statin use.", "The severity of cardiac involvement in amyloidosis can be described by the degree of transmurality of late gadolinium enhancement in MRI."], "hard_negative": "Thigh-length graduated compression stockings (GCS) did not reduce deep vein thrombosis in patients admitted to hospital who are immobile because of acute stroke."}
{"query_id": "1303", "query_text": "Tirasemtiv has no effect on fast-twitch muscle.", "negative": "Peroxynitrite is required for nitration of TCR/CD8.", "negatives": ["Peroxynitrite is required for nitration of TCR/CD8.", "NFAT4 activation requires IP3R-mediated Ca2+ mobilization.", "Combining phosphatidylinositide 3-kinase and MEK 1/2 inhibitors is effective at treating KRAS mutant tumors.", "Hypertension is frequently observed in type 1 diabetes patients.", "Metastatic colorectal cancer treated with a single agent fluoropyrimidines resulted in reduced efficacy and lower quality of life when compared with oxaliplatin-based chemotherapy in elderly patients.", "Auditory entrainment is strengthened when people see congruent visual and auditory information.", "High dietary calcium intakes are unnecessary for prevention of secondary hyperparathyroidism in subjects with 25(OH)D levels above 75 nmol/liter.", "The risk of male prisoners harming themselves is ten times that of female prisoners.", "Macrolides have no protective effect against myocardial infarction.", "Participating in six months of physical activity improves cognitive functioning."], "hard_negatives": ["Tirasemtiv has no effect on fast-twitch muscle.", "High-sensitivity cardiac troponin T (HSCT-T) dosage may not be diagnostic if the onset of symptoms occurs less than 3 hours before acute myocardial injury (AMI).", "T regulatory cells (tTregs) lacking \u03b1v\u03b28 are more adept at suppressing pathogenic T-cell responses during active inflammation.", "mTORC2 regulates intracellular cysteine levels through xCT inhibition.", "IRG1 has antiviral effects against neurotropic viruses.", "Golli-deficient T-cells prefer to differentiate into an anergic phenotype in the adaptive immune response when there are increased levels of Ca2+ in the cytosol.", "Activation of PPM1D suppresses p53 function.", "Reduced responsiveness to interleukin-2 in regulatory T cells is associated with greater resistance to autoimmune diseases such as Type 1 Diabetes.", "Mutant mice lacking SVCT2 have greatly increased ascorbic acid levels in both brain and adrenals.", "Immune responses result in the development of inflammatory Th17 cells and anti-inflammatory iTregs."], "hard_negative": "Tirasemtiv has no effect on fast-twitch muscle."}
{"query_id": "1316", "query_text": "Transferred UCB T cells acquire a memory-like phenotype in recipients.", "negative": "Ivermectin is used to treat lymphatic filariasis.", "negatives": ["Ivermectin is used to treat lymphatic filariasis.", "Cytosolic proteins bind to iron-responsive elements on mRNAs coding for DMT1. Cytosolic proteins bind to iron-responsive elements on mRNAs coding for proteins involved in iron uptake.", "TCR/CD3 microdomains are a required to induce the immunologic synapse to activate T cells.", "Cold exposure reduces BAT recruitment.", "Only a minority of cells survive development after differentiation into stress-resistant spores.", "Ethanol stress decreases the expression of IBP in bacteria.", "Flexible molecules experience greater steric hindrance in the tumor microenviroment than rigid molecules.", "Hyperfibrinogenemia increases rates of femoropopliteal bypass thrombosis.", "cSMAC formation enhances weak ligand signalling.", "Auditory entrainment is strengthened when people see congruent visual and auditory information."], "hard_negatives": ["Transferred UCB T cells acquire a memory-like phenotype in recipients.", "UCB T cells maintain high TCR diversity after transplantation.", "UCB T cells reduce TCR diversity after transplantation.", "In adult tissue, most T cells are memory T cells.", "TCR/CD3 microdomains are a required to induce the immunologic synapse to activate T cells.", "Golli-deficient T-cells prefer to differentiate into an anergic phenotype in the adaptive immune response when there are increased levels of Ca2+ in the cytosol.", "ITAM phosphorylation prevents the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).", "T regulatory cells (tTregs) lacking \u03b1v\u03b28 are more adept at suppressing pathogenic T-cell responses during active inflammation.", "Transplanted human glial progenitor cells are incapable of forming a neural network with host animals' neurons.", "The single flash-evoked ERG b-wave is generated by activity of ON-bipolar cells."], "hard_negative": "Transferred UCB T cells acquire a memory-like phenotype in recipients."}
{"query_id": "1319", "query_text": "Transplanted human glial cells can differentiate within the host animal.", "negative": "Input from  mental and physical health care professionals is effective at decreasing homelessness.", "negatives": ["Input from  mental and physical health care professionals is effective at decreasing homelessness.", "cSMAC formation enhances weak ligand signalling.", "Infection of human T-cell lymphotropic virus type 1 is most frequent in individuals of African origin.", "Macropinocytosis contributes to a cell's supply of amino acids via the intracellular uptake of protein.", "Mercaptopurine is anabolized into the inactive methylmercaptopurine by thiopurine methyltrasnferase (TPMT).", "Asymptomatic visual impairment screening in elderly populations does not lead to improved vision.", "The extracellular domain of TMEM27 is cleaved in human beta cells.", "Antiretroviral therapy reduces rates of tuberculosis across a broad range of CD4 strata.", "High levels of CRP reduces the risk of exacerbations in chronic obstructive pulmonary disease (COPD).", "Integrating classroom-based collaborative learning with Web-based collaborative learning leads to subpar class performance"], "hard_negatives": ["Transplanted human glial cells can differentiate within the host animal.", "Transplanted human glial progenitor cells are incapable of forming a neural network with host animals' neurons.", "Bone marrow cells contribute to adult macrophage compartments.", "Autologous transplantation of mesenchymal stem cells has lower rates of rejection than induction therapy with anti-interleukin-2 receptor antibodies.", "UCB T cells maintain high TCR diversity after transplantation.", "Golli-deficient T-cells prefer to differentiate into an anergic phenotype in the adaptive immune response when there are increased levels of Ca2+ in the cytosol.", "Gene expression does not vary appreciably across genetically identical cells.", "Autologous transplantation of mesenchymal stem cells causes fewer opportunistic infections than induction therapy with anti-interleukin-2 receptor antibodies.", "The US health care system can save up to $750 million if 7% of patients waiting for kidney transplants participate in the optimized national kidney paired donation program.", "UCB T cells reduce TCR diversity after transplantation."], "hard_negative": "Transplanted human glial cells can differentiate within the host animal."}
{"query_id": "1320", "query_text": "Transplanted human glial progenitor cells are incapable of forming a neural network with host animals' neurons.", "negative": "Only a minority of cells survive development after differentiation into stress-resistant spores.", "negatives": ["Only a minority of cells survive development after differentiation into stress-resistant spores.", "Antibiotic induced alterations in the gut microbiome reduce resistance against Clostridium difficile", "Increased microtubule acetylation repairs LRRK2 Roc-COR domain mutation induced locomotor deficits.", "Discrimination between the initiator and elongation tRNAs depends on the translation initiation factor IF3.", "Vitamin D deficiency is unrelated to birth weight.", "The center of the granuloma in an immune cell induces a pro-inflammatory immune response.", "CX3CR1 on the Th2 cells impairs T cell survival", "Podocytes are motile and migrate in the presence of injury.", "Chenodeosycholic acid treatment increases whole-body energy expenditure.", "Microarray results from culture-amplified mixtures of serotypes correlate poorly with microarray results from uncultured mixtures."], "hard_negatives": ["Transplanted human glial progenitor cells are incapable of forming a neural network with host animals' neurons.", "Transplanted human glial cells can differentiate within the host animal.", "Golli-deficient T-cells prefer to differentiate into an anergic phenotype in the adaptive immune response when there are increased levels of Ca2+ in the cytosol.", "Bone marrow cells contribute to adult macrophage compartments.", "Rapid up-regulation and higher basal expression of interferon-induced genes reduce survival of granule cell neurons that are infected by West Nile virus.", "Rapid up-regulation and higher basal expression of interferon-induced genes increase survival of granule cell neurons that are infected by West Nile virus.", "Modifying the epigenome in the brain affects the normal human aging process by affecting certain genes related to neurogenesis.", "In adult tissue, most T cells are memory T cells.", "Autologous transplantation of mesenchymal stem cells has lower rates of rejection than induction therapy with anti-interleukin-2 receptor antibodies.", "T regulatory cells (tTregs) lacking \u03b1v\u03b28 are more adept at suppressing pathogenic T-cell responses during active inflammation."], "hard_negative": "Transplanted human glial progenitor cells are incapable of forming a neural network with host animals' neurons."}
{"query_id": "1332", "query_text": "Tumor necrosis factor alpha (TNF-\u03b1) and interleukin-1 (IL-1) are pro-inflammatory cytokines that inhibit IL-6 and IL-10.", "negative": "Autologous transplantation of mesenchymal stem cells has lower rates of rejection than induction therapy with anti-interleukin-2 receptor antibodies.", "negatives": ["Autologous transplantation of mesenchymal stem cells has lower rates of rejection than induction therapy with anti-interleukin-2 receptor antibodies.", "Activation of PPM1D suppresses p53 function.", "Articles published in open access format are less likely to be cited than traditional journals.", "The center of the granuloma in an immune cell induces a pro-inflammatory immune response.", "Vitamin D deficiency effects the term of delivery.", "Pseudogene PTENP1 regulates the expression of PTEN by functioning as an miRNA decoy.", "A total of 1,000 people in the UK are asymptomatic carriers of vCJD infection.", "Leuko-increased blood increases infectious complications in red blood cell transfusion.", "Transplanted human glial cells can differentiate within the host animal.", "The minor G allele of FOXO3 is related to more severe symptoms of Crohn's Disease."], "hard_negatives": ["Tumor necrosis factor alpha (TNF-\u03b1) and interleukin-1 (IL-1) are pro-inflammatory cytokines that inhibit IL-6 and IL-10.", "Primary pro-inflammatory cytokines induce secondary pro- and anti-inflammatory mediators.", "AMP-activated protein kinase (AMPK) activation increases inflammation-related fibrosis in the lungs.", "Epigenetic modulating agents (EMAs) modulate antitumor immune response in a cancer model system.", "TNFAIP3 is a tumor suppressor in glioblastoma.", "Reduced responsiveness to interleukin-2 in regulatory T cells is associated with greater resistance to autoimmune diseases such as Type 1 Diabetes.", "Crosstalk between dendritic cells (DCs) and innate lymphoid cells (ILCs) is important in the regulation of intestinal homeostasis.", "Immune responses result in the development of inflammatory Th17 cells and anti-inflammatory iTregs.", "T regulatory cells (tTregs) lacking \u03b1v\u03b28 are more adept at suppressing pathogenic T-cell responses during active inflammation.", "The treatment of cancer patients with co-IR blockade precipitates adverse autoimmune events."], "hard_negative": "Tumor necrosis factor alpha (TNF-\u03b1) and interleukin-1 (IL-1) are pro-inflammatory cytokines that inhibit IL-6 and IL-10."}
{"query_id": "1335", "query_text": "UCB T cells maintain high TCR diversity after transplantation.", "negative": "Microarray results from culture-amplified mixtures of serotypes correlate poorly with microarray results from uncultured mixtures.", "negatives": ["Microarray results from culture-amplified mixtures of serotypes correlate poorly with microarray results from uncultured mixtures.", "Enhanced early production of inflammatory chemokines improves viral control in the lung.", "Free histones are degraded by a Rad53-dependent mechanism once DNA has been replicated.", "Exposure to fine particulate air pollution is relate to anxiety prevalence.", "Aspirin inhibits the production of PGE2.", "Increased vessel density along with a reduction in fibrosis decreases the efficacy of chemotherapy treatments.", "Mutations in G-Beta protein GNB2 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.", "Thigh-length graduated compression stockings (GCS) did not reduce deep vein thrombosis in patients admitted to hospital who are immobile because of acute stroke.", "Homozygous deletion of murine Sbds gene from osterix-expressing mesenchymal stem and progenitor cells (MPCs) prevents oxidative stress.", "De novo assembly of sequence data has more specific contigs than unassembled sequence data."], "hard_negatives": ["UCB T cells maintain high TCR diversity after transplantation.", "UCB T cells reduce TCR diversity after transplantation.", "Transferred UCB T cells acquire a memory-like phenotype in recipients.", "TCR/CD3 microdomains are a required to induce the immunologic synapse to activate T cells.", "T regulatory cells (tTregs) lacking \u03b1v\u03b28 are more adept at suppressing pathogenic T-cell responses during active inflammation.", "CX3CR1 on the Th2 cells promotes T cell survival", "In adult tissue, most T cells are memory T cells.", "ITAM phosphorylation prevents the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).", "Golli-deficient T-cells prefer to differentiate into an anergic phenotype in the adaptive immune response when there are increased levels of Ca2+ in the cytosol.", "CX3CR1 on the Th2 cells impairs T cell survival"], "hard_negative": "UCB T cells maintain high TCR diversity after transplantation."}
{"query_id": "1336", "query_text": "UCB T cells reduce TCR diversity after transplantation.", "negative": "Ly6C hi monocytes have a lower inflammatory capacity than Ly6C lo monocytes.", "negatives": ["Ly6C hi monocytes have a lower inflammatory capacity than Ly6C lo monocytes.", "Articles published in open access format are less likely to be cited than traditional journals.", "Antibiotic induced alterations in the gut microbiome reduce resistance against Clostridium difficile", "Discrimination between the initiator and elongation tRNAs depends on the translation initiation factor IF3.", "IRG1 has antiviral effects against neurotropic viruses.", "NF2 (Merlin) prevents phosphorylation and subsequent cytoplasmic sequestration of YAP in Drosophila.", "Lupus-prone mice infected with curliproducing bacteria have higher autoantibody titers compared to controls.", "IFIT1 restricts viral replication by sequestrating mis-capped viral RNAs.", "N-terminal cleavage increases success identifying transcription start sites.", "All hematopoietic stem cells segregate their chromosomes randomly."], "hard_negatives": ["UCB T cells reduce TCR diversity after transplantation.", "UCB T cells maintain high TCR diversity after transplantation.", "Transferred UCB T cells acquire a memory-like phenotype in recipients.", "TCR/CD3 microdomains are a required to induce the immunologic synapse to activate T cells.", "T regulatory cells (tTregs) lacking \u03b1v\u03b28 are more adept at suppressing pathogenic T-cell responses during active inflammation.", "CX3CR1 on the Th2 cells promotes T cell survival", "CX3CR1 on the Th2 cells impairs T cell survival", "ITAM phosphorylation prevents the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).", "In adult tissue, most T cells are memory T cells.", "Reduced responsiveness to interleukin-2 in regulatory T cells is associated with greater resistance to autoimmune diseases such as Type 1 Diabetes."], "hard_negative": "UCB T cells reduce TCR diversity after transplantation."}
{"query_id": "1337", "query_text": "Ubiquitin ligase UBC13 generates a K63-linked polyubiquitin moiety at PCNA K164.", "negative": "Mercaptopurine is anabolized into the inactive methylmercaptopurine by thiopurine methyltrasnferase (TPMT).", "negatives": ["Mercaptopurine is anabolized into the inactive methylmercaptopurine by thiopurine methyltrasnferase (TPMT).", "Hematopoietic Stem Cell purification reaches purity rate of up to 50%.", "Dexamethasone decreases risk of postoperative bleeding.", "The one-child policy has been successful in lowering population growth.", "Reduced responsiveness to interleukin-2 in regulatory T cells is associated with greater resistance to autoimmune diseases such as Type 1 Diabetes.", "CX3CR1 on the Th2 cells promotes airway inflammation.", "Upregulation of mosGCTL-1 is induced upon infection with West Nile virus.", "The tip of the inner tube of the toxic type VI secretion system (T6SS) antibacterial effector in Escherichia coli (E. coli) carries toxic effector proteins.", "The loss of the TET protein functions may have dire biological consequences, such as myeloid cancers.", "The severity of cardiac involvement in amyloidosis can be described by the degree of transmurality of late gadolinium enhancement in MRI."], "hard_negatives": ["Ubiquitin ligase UBC13 generates a K63-linked polyubiquitin moiety at PCNA K164.", "N348I mutations cause resistance to zidovudine (AZT).", "Arginine 90 in p150n is important for interaction with EB1.", "Smc5/6 engagment drives the activation of SUMO E3 ligase Mms21 by ATP-dependent remolding.", "The extracellular domain of TMEM27 is cleaved in human beta cells.", "The ureABIEFGH gene cluster is induced by nickel (II) ion.", "Localization of PIN1 in the roots of Arabidopsis does not require VPS9a", "Localization of PIN1 in the Arabidopsis embryo does not require VPS9a", "Replacement of histone H2A with H2A.Z slows gene activation in yeasts by stabilizing +1 nucleosomes.", "Occupancy of ribosomes by IncRNAs mirror 5 0-UTRs"], "hard_negative": "Ubiquitin ligase UBC13 generates a K63-linked polyubiquitin moiety at PCNA K164."}
{"query_id": "1339", "query_text": "Ultrasound guidance significantly raises the number of traumatic procedures when attempting needle insertion.", "negative": "Macrolides protect against myocardial infarction.", "negatives": ["Macrolides protect against myocardial infarction.", "Auditory entrainment is strengthened when people see congruent visual and auditory information.", "NR5A2 is important in development of endometrial tissues.", "Helminths interfere with immune system control of macrophages activated by IL-4 favor Mycobacterium tuberculosis replication.", "Leuko-reduced blood reduces infectious complications in red blood cell transfusion.", "Articles published in open access format are more likely to be cited than traditional journals.", "PD-1 triggering on monocytes reduces IL-10 production by monocytes.", "Ethanol stress decreases the expression of IBP in bacteria.", "Hyperfibrinogenemia increases rates of femoropopliteal bypass thrombosis.", "Cells undergoing methionine restriction may activate miRNAs."], "hard_negatives": ["Ultrasound guidance significantly raises the number of traumatic procedures when attempting needle insertion.", "Errors in peripheral IV drug administration are most common during bolus administration and multiple-step medicine preparations.", "Stroke patients with prior use of direct oral anticoagulants have a lower risk of in-hospital mortality than stroke patients with prior use of warfarin.", "Non-invasive ventilation use should be decreased if there is inadequate response to conventional treatment.", "Auditory entrainment is strengthened when people see congruent visual and auditory information.", "CRP is not predictive of postoperative mortality following Coronary Artery Bypass Graft (CABG) surgery.", "There is an inverse relationship between hip fractures and statin use.", "Bariatric surgery has a positive impact on mental health.", "Primary cervical cancer screening with HPV detection has higher longitudinal sensitivity than conventional cytology to detect cervical intraepithelial neoplasia grade 2.", "Incidence rates of cervical cancer have increased due to nationwide screening programs based primarily on cytology to detect uterine cervical cancer."], "hard_negative": "Ultrasound guidance significantly raises the number of traumatic procedures when attempting needle insertion."}
{"query_id": "1344", "query_text": "Up-regulation of the p53 pathway and related molecular events casues cancer resistance and results in a significantly shortened lifespan marked by senescent cells and accelerated organismal aging.", "negative": "LDL cholesterol has no involvement in the development of cardiovascular disease.", "negatives": ["LDL cholesterol has no involvement in the development of cardiovascular disease.", "Silencing of Bcl2 is important for the maintenance and progression of tumors.", "Participating in six months of physical activity improves cognitive functioning.", "1/2000 in UK have abnormal PrP positivity.", "Occupancy of ribosomes by IncRNAs do not make functional peptides.", "Stroke patients with prior use of direct oral anticoagulants have a lower risk of in-hospital mortality than stroke patients with prior use of warfarin.", "Occupancy of ribosomes by IncRNAs do not make functional peptides.", "Cold exposure increases BAT recruitment.", "FoxO3a activation in neuronal death is mediated by reactive oxygen species (ROS).", "Rapid up-regulation and higher basal expression of interferon-induced genes reduce survival of granule cell neurons that are infected by West Nile virus."], "hard_negatives": ["Up-regulation of the p53 pathway and related molecular events casues cancer resistance and results in a significantly shortened lifespan marked by senescent cells and accelerated organismal aging.", "Activation of PPM1D suppresses p53 function.", "Breast cancer development is determined exclusively by genetic factors.", "Modifying the epigenome in the brain affects the normal human aging process by affecting certain genes related to neurogenesis.", "Epigenetic modulating agents (EMAs) modulate antitumor immune response in a cancer model system.", "Tumor necrosis factor alpha (TNF-\u03b1) and interleukin-1 (IL-1) are pro-inflammatory cytokines that inhibit IL-6 and IL-10.", "PGE 2 promotes intestinal tumor growth by altering the expression of tumor suppressing and DNA repair genes.", "Pseudogene PTENP1 regulates the expression of PTEN by functioning as an miRNA decoy.", "Normal expression of RUNX1 has tumor-promoting effects.", "The loss of the TET protein functions may have dire biological consequences, such as myeloid cancers."], "hard_negative": "Up-regulation of the p53 pathway and related molecular events casues cancer resistance and results in a significantly shortened lifespan marked by senescent cells and accelerated organismal aging."}
{"query_id": "1352", "query_text": "Upregulation of mosGCTL-1 is induced upon infection with West Nile virus.", "negative": "T regulatory cells (tTregs) lacking \u03b1v\u03b28 are more adept at suppressing pathogenic T-cell responses during active inflammation.", "negatives": ["T regulatory cells (tTregs) lacking \u03b1v\u03b28 are more adept at suppressing pathogenic T-cell responses during active inflammation.", "Cold exposure reduces BAT recruitment.", "Leukemia associated Rho guanine nucleotide-exchange factor represses RhoA in response to SRC activation.", "Flexible molecules experience greater steric hindrance in the tumor microenviroment than rigid molecules.", "Insomnia can be effectively treated with cognitive behavioral therapy.", "Cytosolic proteins bind to iron-responsive elements on mRNAs coding for DMT1. Cytosolic proteins bind to iron-responsive elements on mRNAs coding for proteins involved in iron uptake.", "Metastatic colorectal cancer treated with a single agent fluoropyrimidines resulted in reduced efficacy and lower quality of life when compared with oxaliplatin-based chemotherapy in elderly patients.", "N-terminal cleavage reduces success identifying transcription start sites.", "Combining phosphatidylinositide 3-kinase and MEK 1/2 inhibitors is effective at treating KRAS mutant tumors.", "The risk of male prisoners harming themselves is ten times that of female prisoners."], "hard_negatives": ["Upregulation of mosGCTL-1 is induced upon infection with West Nile virus.", "Rapid up-regulation and higher basal expression of interferon-induced genes reduce survival of granule cell neurons that are infected by West Nile virus.", "Rapid up-regulation and higher basal expression of interferon-induced genes increase survival of granule cell neurons that are infected by West Nile virus.", "Infection of human T-cell lymphotropic virus type 1 is most frequent in individuals of African origin.", "Mutant mice lacking SVCT2 have greatly increased ascorbic acid levels in both brain and adrenals.", "Immune complex triggered cell death leads to extracellular release of neutrophil protein HMGB1.", "Human T-lymphotropic virus type-I-associated myelopathy / tropical spastic paraparesis (HAM/TSP) patients produce Immunoglobulin G (IgG) antibodies which cross-react with an immunodominant epitope in Tax.", "mTORC2 regulates intracellular cysteine levels through xCT inhibition.", "In mouse models, the loss of CSF1R facilitates MOZ-TIF2-induced leuekmogenesis.", "Tetraspanin-3 is a causative factor in the development of acute myelogenous leukemia"], "hard_negative": "Upregulation of mosGCTL-1 is induced upon infection with West Nile virus."}
{"query_id": "1359", "query_text": "Varenicline monotherapy is more effective after 12 weeks of treatment compared to combination nicotine replacement therapies with varenicline or bupropion.", "negative": "APOE4 expression in iPSC-derived neurons increases AlphaBeta production and tau phosphorylation causing GABA neuron degeneration.", "negatives": ["APOE4 expression in iPSC-derived neurons increases AlphaBeta production and tau phosphorylation causing GABA neuron degeneration.", "Pretreatment with the Arp2/3 inhibitor CK-666 affects lamelliopodia formation.", "Human T-lymphotropic virus type-I-associated myelopathy / tropical spastic paraparesis (HAM/TSP) patients produce Immunoglobulin G (IgG) antibodies which cross-react with an immunodominant epitope in Tax.", "Leuko-increased blood increases infectious complications in red blood cell transfusion.", "Deletion of \u03b1v\u03b28 does not result in a spontaneous inflammatory phenotype.", "Smc5/6 engagment drives the activation of SUMO E3 ligase Mms21 by ATP-dependent remolding.", "Gene expression does not vary appreciably across genetically identical cells.", "Cold exposure reduces BAT recruitment.", "Enhanced early production of inflammatory chemokines improves viral control in the lung.", "Mice without IFN-\u03b3 or its receptor are resistant to EAM induced with \u03b1-MyHC/CFA."], "hard_negatives": ["Varenicline monotherapy is more effective after 12 weeks of treatment compared to combination nicotine replacement therapies with varenicline or bupropion.", "Combination nicotine replacement therapies with varenicline or bupropion lead to significantly higher long-term abstinence rates at 52 weeks than varenicline monotherapy.", "Sildenafil improves erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.", "Stroke patients with prior use of direct oral anticoagulants have a lower risk of in-hospital mortality than stroke patients with prior use of warfarin.", "Dexamethasone decreases risk of postoperative bleeding.", "Antiretroviral therapy reduces rates of tuberculosis across a broad range of CD4 strata.", "The benefits of colchicine were achieved with effective widespread use of secondary prevention strategies such as high-dose statins.", "Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have a dramatic impact in reducing malaria transmission.", "Metastatic colorectal cancer treated with a single agent fluoropyrimidines resulted in reduced efficacy and lower quality of life when compared with oxaliplatin-based chemotherapy in elderly patients.", "The relationship between a breast cancer patient's capacity to metabolize tamoxifen and treatment outcome is dependent on the patient's genetic make-up."], "hard_negative": "Varenicline monotherapy is more effective after 12 weeks of treatment compared to combination nicotine replacement therapies with varenicline or bupropion."}
{"query_id": "1362", "query_text": "Venules have a larger lumen diameter than arterioles.", "negative": "Macrolides have no protective effect against myocardial infarction.", "negatives": ["Macrolides have no protective effect against myocardial infarction.", "PPAR-RXRs are inhibited by PPAR ligands.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have increased risk for dementia.", "N348I mutations cause resistance to zidovudine (AZT).", "Localization of PIN1 in the Arabidopsis embryo does not require VPS9a", "Venules have a larger lumen diameter than arterioles.", "Basophils counteract disease development in patients with systemic lupus erythematosus (SLE).", "Gene expression does not vary appreciably across genetically identical cells.", "Enhanced early production of inflammatory chemokines improves viral control in the lung.", "Sildenafil improves erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants."], "hard_negatives": ["Venules have a larger lumen diameter than arterioles.", "Arterioles have a larger lumen diameter than venules.", "Venules have a thinner or absent smooth layer compared to arterioles.", "Flexible molecules experience greater steric hindrance in the tumor microenviroment than rigid molecules.", "Podocytes are motile and migrate in the presence of injury.", "Pyridostatin destabilizes the G - quadruplex in the telomeric region.", "PDPN promotes efficient motility along stromal surfaces by activating the C-type lectin receptor to rearrange the actin cytoskeleton in dendritic cells.", "Nanoparticles can be targeted against specific cell types by incorporating aptamers into lipid nanoparticles.", "The PRR MDA5 has a central DExD/H RNA helices domain.", "Ultrasound guidance significantly raises the number of traumatic procedures when attempting needle insertion."], "hard_negative": "Venules have a larger lumen diameter than arterioles."}
{"query_id": "1363", "query_text": "Venules have a thinner or absent smooth layer compared to arterioles.", "negative": "CX3CR1 on the Th2 cells impairs T cell survival", "negatives": ["CX3CR1 on the Th2 cells impairs T cell survival", "Occupancy of ribosomes by IncRNAs mirror 5 0-UTRs", "Pseudogene PTENP1 regulates the expression of PTEN by functioning as an miRNA decoy.", "Cytosolic proteins bind to iron-responsive elements on mRNAs coding for DMT1. Cytosolic proteins bind to iron-responsive elements on mRNAs coding for proteins involved in iron uptake.", "Gene expression does not vary appreciably across genetically identical cells.", "Tumor necrosis factor alpha (TNF-\u03b1) and interleukin-1 (IL-1) are pro-inflammatory cytokines that inhibit IL-6 and IL-10.", "Ivermectin is used to treat onchocerciasis.", "Thigh-length graduated compression stockings (GCS) did not reduce deep vein thrombosis in patients admitted to hospital who are immobile because of acute stroke.", "Cell autonomous sex determination in somatic cells occurs in Passeriformes.", "Hypothalamic glutamate neurotransmission is crucial to energy balance."], "hard_negatives": ["Venules have a thinner or absent smooth layer compared to arterioles.", "Venules have a larger lumen diameter than arterioles.", "Arterioles have a larger lumen diameter than venules.", "Flexible molecules experience greater steric hindrance in the tumor microenviroment than rigid molecules.", "Podocytes are motile and migrate in the presence of injury.", "Nanoparticles can be targeted against specific cell types by incorporating aptamers into lipid nanoparticles.", "The genomic aberrations found in matasteses are very similar to those found in the primary tumor.", "Ribosomopathies have a low degree of cell and tissue specific pathology.", "Pyridostatin destabilizes the G - quadruplex in the telomeric region.", "Thigh-length graduated compression stockings (GCS) did not reduce deep vein thrombosis in patients admitted to hospital who are immobile because of acute stroke."], "hard_negative": "Venules have a thinner or absent smooth layer compared to arterioles."}
{"query_id": "1368", "query_text": "Vitamin D deficiency effects the term of delivery.", "negative": "Pyridostatin destabilizes the G - quadruplex in the telomeric region.", "negatives": ["Pyridostatin destabilizes the G - quadruplex in the telomeric region.", "Ly6C hi monocytes have a lower inflammatory capacity compared to their Ly6C lo counterparts.", "Fz/PCP-dependent Pk localizes to the anterior membrane of neuroectoderm cells during zebrafish neuralation", "Statins decrease blood cholesterol.", "Immune responses result in the development of inflammatory Th17 cells and anti-inflammatory iTregs.", "The benefits of colchicine were achieved with effective widespread use of secondary prevention strategies such as high-dose statins.", "In transgenic mice harboring green florescent protein under the control of the Sox2 promoter, less than ten percent of the cells with green florescent colocalize with cell proliferation markers.", "Cells undergoing methionine restriction may activate miRNAs.", "Febrile seizures increase the threshold for development of epilepsy.", "Macrolides protect against myocardial infarction."], "hard_negatives": ["Vitamin D deficiency effects the term of delivery.", "Vitamin D deficiency is unrelated to birth weight.", "A deficiency of vitamin B12 increases blood levels of homocysteine.", "The relationship between a breast cancer patient's capacity to metabolize tamoxifen and treatment outcome is dependent on the patient's genetic make-up.", "Antiretroviral therapy reduces rates of tuberculosis across a broad range of CD4 strata.", "Individuals with low serum vitamin D concentrations have increased risk of multiple sclerosis.", "Dexamethasone decreases risk of postoperative bleeding.", "High dietary calcium intakes are unnecessary for prevention of secondary hyperparathyroidism in subjects with 25(OH)D levels above 75 nmol/liter.", "Deletion of \u03b1v\u03b28 does not result in a spontaneous inflammatory phenotype.", "LDL cholesterol has no involvement in the development of cardiovascular disease."], "hard_negative": "Vitamin D deficiency effects the term of delivery."}
{"query_id": "1370", "query_text": "Vitamin D deficiency is unrelated to birth weight.", "negative": "Hypertension is frequently observed in type 1 diabetes patients.", "negatives": ["Hypertension is frequently observed in type 1 diabetes patients.", "Neutrophil extracellular traps (NETs) are released by ANCA-stimulated neutrophils.", "ADAR1 binds to Dicer to cleave pre-miRNA.", "Recurrent mutations occur frequently within CTCF anchor sites adjacent to oncogenes.", "Integrating classroom-based collaborative learning with Web-based collaborative learning leads to subpar class performance", "In domesticated populations of Saccharomyces cerevisiae, whole chromosome aneuploidy is very uncommon.", "In transgenic mice harboring green florescent protein under the control of the Sox2 promoter, less than ten percent of the cells with green florescent colocalize with cell proliferation markers.", "Birth-weight is positively associated with breast cancer.", "T regulatory cells (tTregs) lacking \u03b1v\u03b28 are more adept at suppressing pathogenic T-cell responses during active inflammation.", "Articles published in open access format are less likely to be cited than traditional journals."], "hard_negatives": ["Vitamin D deficiency is unrelated to birth weight.", "Vitamin D deficiency effects the term of delivery.", "A deficiency of vitamin B12 increases blood levels of homocysteine.", "Birth-weight is positively associated with breast cancer.", "5% of perinatal mortality is due to low birth weight.", "Individuals with low serum vitamin D concentrations have increased risk of multiple sclerosis.", "LDL cholesterol has no involvement in the development of cardiovascular disease.", "Obesity is determined solely by environmental factors.", "HNF4A mutations can cause diabetes in mutant carriers by the age of 14 years", "High dietary calcium intakes are unnecessary for prevention of secondary hyperparathyroidism in subjects with 25(OH)D levels above 75 nmol/liter."], "hard_negative": "Vitamin D deficiency is unrelated to birth weight."}
{"query_id": "1379", "query_text": "Women with a higher birth weight are more likely to develop breast cancer later in life.", "negative": "The myocardial lineage develops from cardiac progenitors of mesodermal origin.", "negatives": ["The myocardial lineage develops from cardiac progenitors of mesodermal origin.", "Peroxynitrite is required for nitration of TCR/CD8.", "The composition of myosin-II isoform switches from the polarizable B isoform to the more homogenous A isoform during hematopoietic differentiation.", "Ethanol stress decreases the expression of IBP in bacteria.", "Subcutaneous fat depots undergo extensive browning processes after cold exposure.", "Hypocretin neurones induce panicprone state in rats.", "Neutrophil extracellular traps (NETs) are released by ANCA-stimulated neutrophils.", "Fz/PCP-dependent Pk localizes to the anterior membrane of neuroectoderm cells during zebrafish neuralation", "Autophagy declines in aged organisms.", "Angiotensin converting enzyme inhibitors are associated with increased risk for functional renal insufficiency."], "hard_negatives": ["Women with a higher birth weight are more likely to develop breast cancer later in life.", "Birth-weight is positively associated with breast cancer.", "The risk of breast cancer among parous women increases with placental weight of pregnancies, and this association is strongest for premenopausal breast cancer.", "Breast cancer development is determined exclusively by genetic factors.", "Incidence rates of cervical cancer have increased due to nationwide screening programs based primarily on cytology to detect uterine cervical cancer.", "Incidence rates of cervical cancer have decreased.", "5% of perinatal mortality is due to low birth weight.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have increased risk for dementia.", "Incidence of heart failure decreased by 10% in women since 1979.", "The relationship between a breast cancer patient's capacity to metabolize tamoxifen and treatment outcome is dependent on the patient's genetic make-up."], "hard_negative": "Women with a higher birth weight are more likely to develop breast cancer later in life."}
{"query_id": "1382", "query_text": "aPKCz causes tumour enhancement by affecting glutamine metabolism.", "negative": "N-terminal cleavage increases success identifying transcription start sites.", "negatives": ["N-terminal cleavage increases success identifying transcription start sites.", "Activation of PPM1D suppresses p53 function.", "ALDH1 expression is associated with poorer prognosis in breast cancer.", "The locus rs647161 is associated with colorectal carcinoma.", "Primary cervical cancer screening with HPV detection has higher longitudinal sensitivity than conventional cytology to detect cervical intraepithelial neoplasia grade 2.", "Low expression of miR7a does represses target genes and exerts a biological function in ovaries.", "Headaches are not correlated with cognitive impairment.", "N-terminal cleavage reduces success identifying transcription start sites.", "Lymphadenopathy is observed in knockin mouse lacking the SHP-2 MAPK pathway.", "Basophils counteract disease development in patients with systemic lupus erythematosus (SLE)."], "hard_negatives": ["aPKCz causes tumour enhancement by affecting glutamine metabolism.", "ALDH1 expression is associated with better breast cancer outcomes.", "mTORC2 regulates intracellular cysteine levels through xCT inhibition.", "ALDH1 expression is associated with poorer prognosis in breast cancer.", "Low expression of miR7a does represses target genes and exerts a biological function in ovaries.", "Mutations in G-Beta protein GNB2 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.", "AMP-activated protein kinase (AMPK) activation increases inflammation-related fibrosis in the lungs.", "Hypothalamic glutamate neurotransmission is crucial to energy balance.", "TNFAIP3 is a tumor suppressor in glioblastoma.", "CHEK2 is not associated with breast cancer."], "hard_negative": "aPKCz causes tumour enhancement by affecting glutamine metabolism."}
{"query_id": "1385", "query_text": "cSMAC formation enhances weak ligand signalling.", "negative": "Radioiodine treatment of non-toxic multinodular goitre reduces thyroid volume.", "negatives": ["Radioiodine treatment of non-toxic multinodular goitre reduces thyroid volume.", "A total of 1,000 people in the UK are asymptomatic carriers of vCJD infection.", "The binding orientation of the ML-SA1 activator at hTRPML2 is different from the binding orientation of the ML-SA1 activator at hTRPML1.", "Localization of PIN1 in the Arabidopsis embryo does not require VPS9a", "Glycolysis is one of the primary glycometabolic pathways in cells.", "Replacement of histone H2A with H2A.Z slows gene activation in yeasts by stabilizing +1 nucleosomes.", "Normal expression of RUNX1 has tumor-promoting effects.", "There is an inverse relationship between hip fractures and statin use.", "GATA-3 is important for hematopoietic stem cell (HSC) function.", "There is no association between HNF4A mutations and diabetes risks."], "hard_negatives": ["cSMAC formation enhances weak ligand signalling.", "Deleting Raptor reduces G-CSF levels.", "mTORC2 regulates intracellular cysteine levels through xCT inhibition.", "In mouse models, the loss of CSF1R facilitates MOZ-TIF2-induced leuekmogenesis.", "TCR/CD3 microdomains are a required to induce the immunologic synapse to activate T cells.", "Smc5/6 engagment drives the activation of SUMO E3 ligase Mms21 by ATP-dependent remolding.", "aPKCz causes tumour enhancement by affecting glutamine metabolism.", "Synaptic activity enhances local release of brain derived neurotrophic factor from postsynaptic dendrites.", "Ly49Q directs the organization of neutrophil migration to inflammation sites by regulating membrane raft functions.", "Mice without IFN-\u03b3 or its receptor are resistant to EAM induced with \u03b1-MyHC/CFA."], "hard_negative": "cSMAC formation enhances weak ligand signalling."}
{"query_id": "1389", "query_text": "mTORC2 regulates intracellular cysteine levels through xCT inhibition.", "negative": "Obesity decreases life quality.", "negatives": ["Obesity decreases life quality.", "Suboptimal nutrition is not predictive of chronic disease", "Lymphadenopathy is observed in knockin mouse lacking the SHP-2 MAPK pathway.", "Albendazole is used to treat lymphatic filariasis.", "Assembly of invadopodia is triggered by focal generation of phosphatidylinositol-3,4-biphosphate and the activation of the nonreceptor tyrosine kinase Src.", "Golli-deficient T-cells prefer to differentiate into an anergic phenotype in the adaptive immune response when there are increased levels of Ca2+ in the cytosol.", "CX3CR1 on the Th2 cells promotes T cell survival", "Varenicline monotherapy is more effective after 12 weeks of treatment compared to combination nicotine replacement therapies with varenicline or bupropion.", "Aspirin inhibits the production of PGE2.", "Human T-lymphotropic virus type-I-associated myelopathy / tropical spastic paraparesis (HAM/TSP) patients produce Immunoglobulin G (IgG) antibodies which cross-react with an immunodominant epitope in Tax."], "hard_negatives": ["mTORC2 regulates intracellular cysteine levels through xCT inhibition.", "ITAM phosphorylation prevents the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).", "A deficiency of vitamin B12 increases blood levels of homocysteine.", "Mutant mice lacking SVCT2 have greatly increased ascorbic acid levels in both brain and adrenals.", "CHEK2 is not associated with breast cancer.", "NFAT4 activation requires IP3R-mediated Ca2+ mobilization.", "Cytosolic proteins bind to iron-responsive elements on mRNAs coding for DMT1. Cytosolic proteins bind to iron-responsive elements on mRNAs coding for proteins involved in iron uptake.", "CX3CR1 on the Th2 cells impairs T cell survival", "In mouse models, the loss of CSF1R facilitates MOZ-TIF2-induced leuekmogenesis.", "Reduced responsiveness to interleukin-2 in regulatory T cells is associated with greater resistance to autoimmune diseases such as Type 1 Diabetes."], "hard_negative": "mTORC2 regulates intracellular cysteine levels through xCT inhibition."}
{"query_id": "1395", "query_text": "p16INK4A accumulation is  linked to an abnormal wound response caused by the microinvasive step of advanced Oral Potentially Malignant Lesions (OPMLs).", "negative": "There is no association between HNF4A mutations and diabetes risks.", "negatives": ["There is no association between HNF4A mutations and diabetes risks.", "Less than 10% of the gabonese children with Schimmelpenning-Feuerstein-Mims syndrome (SFM) had a plasma lactate of more than 5mmol/L.", "Proteins synthesized at the growth cone are ubiquitinated at a higher rate than proteins from the cell body.", "Gene expression does not vary appreciably across genetically identical cells.", "Cell autonomous sex determination in somatic cells does not occur in Galliformes.", "PPAR-RXRs are inhibited by PPAR ligands.", "Many proteins in human cells can be post-translationally modified at lysine residues via acetylation.", "During the primary early antibody response activated B cells migrate toward the inner-and outer paracortical areas where oxysterol accumulation is generated by stromal cells.", "Lymphadenopathy is observed in knockin mouse lacking the SHP-2 MAPK pathway.", "Golli-deficient T-cells prefer to differentiate into an anergic phenotype in the adaptive immune response when there are increased levels of Ca2+ in the cytosol."], "hard_negatives": ["p16INK4A accumulation is  linked to an abnormal wound response caused by the microinvasive step of advanced Oral Potentially Malignant Lesions (OPMLs).", "PKG-la plays an essential role in expression of pain hypersensitivity in PGK-la knockout mice.", "Deletion of \u03b1v\u03b28 does not result in a spontaneous inflammatory phenotype.", "Arginine 90 in p150n is important for interaction with EB1.", "APOE4 expression in iPSC-derived neurons increases AlphaBeta production and tau phosphorylation, delaying GABA neuron degeneration.", "FoxO3a activation in neuronal death is mediated by reactive oxygen species (ROS).", "Activation of PPM1D suppresses p53 function.", "TNFAIP3 is a tumor suppressor in glioblastoma.", "Mice defective for deoxyribonucleic acid (DNA) polymerase I (polI) reveal increased sensitivity to ionizing radiation (IR).", "Blocking the interaction between TDP-43 and respiratory complex I proteins ND3 and ND6 leads to increased TDP-43-induced neuronal loss."], "hard_negative": "p16INK4A accumulation is  linked to an abnormal wound response caused by the microinvasive step of advanced Oral Potentially Malignant Lesions (OPMLs)."}