The H3.3K36me3 histone reader protein ZMYND11 has a  higher binding affinity if G34R/V is mutated.

Mice are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.

Healthy volunteers exhibit rapid and transient decrease of cellular ATP after being bolus-injected with fructose.

Proteins synthesized at the growth cone are ubiquitinated at a lower rate than proteins from the cell body.

Major vault protein (MVP) functions to decrease tumor aggression.

CRY proteins mediate light signal transduction.

No strong relationship has been found with Pioglitazone use and increased risk for pancreatic cancer

G-CSF prevents MDSCs from infiltrating tumors.

Nrde-3 facilitates heritable silencing in C. elegans by transporting secondary siRNAs to the nucleus.

Self-advocacy training is not effective at decreasing homelessness.

An N-formyl group on M3 molecules suppresss strong binding to the second position of the groove.

Lysine histone demethylase inhibitor JIB 04 is primarily active against KDM5A.

N348I mutations decrease resistance to zidovudine (AZT).

The first MBT repeat of the four malignant brain tumor (4MBT) domain of Drosophila's Sfmbt and of the orthologous mammalian L3MBTL2 is nonessential for the interaction with the spacer region of Drosophila's Pleiohomeotic (Pho) or its human ortholog YY1.

The phosphorylation of Drp1 at S616 site inhibits its mitochondrial translocation when activated by Ca 2+ /calmodulin-dependent kinase II (CaMKII).

The phosphorylation of Drp1 at S616 site promotes its mitochondrial translocation when activated by Ca 2+ /calmodulin-dependent kinase II (CaMKII).

S-nitrosylated GAPDH physiologically transnitrosylates DNA-activated protein kinase.

Broadly HIV-1 Neutralizing Antibodies (bnAb) 10EB exhibit a strong affinity for phospholipids.


The PDPN gene activates the C-type lectin receptor (CLEC-2).

Synaptic activity impairs local release of brain derived neurotrophic factor from postsynaptic dendrites.

Sweet taste receptors on the tongue are activated by between 300 and 1000 mM glucose.

Side effects associated with antidepressants decrease risk of stroke.

C-Met is involved in epithelial-mesenchymal transition in tumor cells.

Increased expression of Bcl2 is important for the maintenance and progression of tumors.

Incidence rates of cervical cancer have increased over time.

Polyglutamine binding protein 1 (PQBP1) is the co-receptor of HIV-DNA to trigger cell-autonomous antiviral responses.

Bronchial responsiveness is higher in the summer than in the winter.

Mitochondria play a major role in calcium homeostasis.

The C-type lectin receptor (CLEC-2) rearranges the actin cytoskeleton in dendritic cells to suppress motility along stromal surfaces.

Deltex has been shown to interact with eIF3f, a DUB required for Notch activation process.

Serotonin receptors play a role in depression

mTORC2 inhibits xCT antiporter through phosphorylation.

NLRP12 is a positive regulator of T-cell receptor activation.

Serotonin receptors have no effect on depression

Conformational changes of the CD3 complex enable ITAM phosphorylation.

LSD1 plays a role in transcriptional activation


The actual sequences of CP-1 and CR-5 regions are evolutionarily conserved throughout most eukaryotes.

Pseudoknots are evolutionarily conserved throughout most eukaryotes.

Genome size differences in rice are explained by LTR retrotransposon expansion.

Hematopoietic progenitor cells are never susceptible to HIV-1 infection ex vivo.

The first MBT repeat of the four malignant brain tumor (4MBT) domain of Drosophila's Sfmbt and of the orthologous mammalian L3MBTL2 is nonessential for the interaction with the spacer region of Drosophila's Pleiohomeotic (Pho) or its human ortholog YY1.

Teaching hospitals provide better care than non-teaching hospitals.

The center of the granuloma in an immune cell induces an anti-inflammatory immune response.

The binding orientation of the ML-SA1 activator at hTRPML2 is similar to the binding orientation of the ML-SA1 activator at hTRPML1.

The minor G allele of FOXO3 represses IL-10.

MEK inhibitors are not effective in RAS-driven mouse models of cancer.

DUSP4 downregulation activates the Ras-ERK pathway

Distant CREs are more conserved among species.

All six cathelicidins are located on chromosome two.

Ultrafine Anaphase Bridges represent a mechanism for resolving partially-replicated stretches of DNA.

High methylation levels within individual DNA molecules correlates with high nucleosome occupancy across species.

High methylation levels within individual DNA molecules correlates with low nucleosome occupancy across species.

Some signals for alternative polyadenylation sites are encoded in transposable elements.

Coordinated stabilization of kinetochore-microtubule attachments occurs at the prometaphase to metaphase transition.

The ring complexes of chromosomes in C. elegans oocytes are built in discrete layers.


The appearance of brown-like or beige cells primarily occurs in subcutaneous fat, not visceral fat.

Ginger is hazardous to mechanically ventilated patients, because these patients are susceptible to mucosal lesions and ulcers.

Gastric lavage shows no benefit for acute paraquat poisoning.

Thoracic aortic aneurysms affect 70-100 individuals per 100,000 people per year.

Mitochondria are uninvolved in processes related to cell signaling.

Antibiotic induced alterations in the gut microbiome increase resistance against Clostridium difficile

Adult tissue-resident macrophages possess a self-renewing capacity.

Long-term use of statins showed a increased risk of gallstones followed by cholecystectomy.

Choice of specialty is not influenced by debt accrued from medical training.

There are four spatial channels in each hemifield of the auditory cortex of cats.

Hematopoietic progenitor cells are never susceptible to HIV-1 infection ex vivo.

The tissue surrounding the granuloma in an immune cell induces an inflammatory immune response.

The center of the granuloma in an immune cell induces an anti-inflammatory immune response.

Tuberculosis-induced granulomas express immune system protein signatures similar to those of the surrounding tissue.

Mitochondria play a major role in calcium homeostasis.

Inside the body, falciparum parasites form agglomerates of infected cells to avoid spleen clearance.

RUNX is a top ranscription factor in skin tissue.

Proteins synthesized at the growth cone are ubiquitinated at a lower rate than proteins from the cell body.

Polyploidization in megakaryocytes occurs in the presence of an aberrant mitosis.

Bromodomain proteins promote the differentiation process of bloodstream form (BSF) to procyclic form (PCF) parasites.


The balance between F- and G-actin regulates the orientation of neuronal migration in the developing cerebral cortex.

The periosteum consists of 2 layers: the inner layer on the periosteal surface with monocyte/macrophage-lineage cells, osteoblastic cells, and abundant periostin; and the outer layer, consisting of collagens, blood vessels, and nerve endings.

Cost effectiveness evaluations based on cRCT data do not represent patients in actual clinical practice.

Thigh-length graduated compression stockings (GCS) reduced deep vein thrombosis in patients admitted to hospital who are immobile because of acute stroke.

The PDPN gene activates the C-type lectin receptor (CLEC-2).

Pyridostatin increases telomere fragility in BRCA2-deficient cells.

Verbal autopsy (VA) performed well in distinguishing between different injury categories in the elderly population.

Short British students are bullied less than control British students.

Distant CREs are more conserved among species.

The phosphorylation of Drp1 at S616 site promotes its mitochondrial translocation when activated by Ca 2+ /calmodulin-dependent kinase II (CaMKII).

Tet enzymes activate microRNAs required for iPSC derivation.

There are four spatial channels in each hemifield of the auditory cortex of cats.

Electrophysiological changes in motor neurons have been observed in patients with amyotrophic lateral sclerosis.

Synaptic activity impairs local release of brain derived neurotrophic factor from postsynaptic dendrites.

Occipital activation levels are not correlated with auditory spatial performance in parietal regions of the brain.

Motor neurons from patients with amyotrophic lateral sclerosis have electrophysiological changes relative to healthy patients.

Synaptic activity impairs local synthesis of brain derived neurotrophic factor from postsynaptic dendrites.

p53 controls autophagy through the AMPK/mTOR-dependent pathway.

Synaptic activity enhances local synthesis of brain derived neurotrophic factor from postsynaptic dendrites.

Serotonin receptors play a role in depression


The binding orientation of the ML-SA1 activator at hTRPML2 is similar to the binding orientation of the ML-SA1 activator at hTRPML1.

Persister cells lead to clinical relapse in cancer patients.

Serotonin receptors have no effect on depression

Impaired RhoA activity causes megakaryocytes to exit mitosis without complete karyokinesis

The appearance of brown-like or beige cells primarily occurs in subcutaneous fat, not visceral fat.

AZT given with ribavirin alleviates anemia.

Consumption of whole fruits reduces the risk of type 2 diabetes.

β1/Ketel is unable to bind microtubules.

The risk of cancer is lower in individuals with a history of heavy alcohol consumption.

c-MYC is important for maintaining pluripotent state of pluripotent stem cells.

Hematopoietic progenitor cells are never susceptible to HIV-1 infection ex vivo.

The phosphorylation of Drp1 at S616 site inhibits its mitochondrial translocation when activated by Ca 2+ /calmodulin-dependent kinase II (CaMKII).

Intramembrane cleavage by SPP helps facilitate in the degradation of proteins with a complex membrane orientation.

LSD1 plays a role in transcriptional activation

The phosphorylation of Drp1 at S616 site promotes its mitochondrial translocation when activated by Ca 2+ /calmodulin-dependent kinase II (CaMKII).

Localization of PIN1 in the Arabidopsis embryo requires VPS9a

Conformational changes of the CD3 complex enable ITAM phosphorylation.

Inhibiting glucose-6-phospate dehydrogenase impairs lipogenesis by reactivating LKB1-AMPK signaling.

The C-type lectin receptor (CLEC-2) rearranges the actin cytoskeleton in dendritic cells to suppress motility along stromal surfaces.

All phenotypes associated with reduced IIS require the gene daf-16.


The center of the granuloma in an immune cell induces an anti-inflammatory immune response.

Self-advocacy training is not effective at decreasing homelessness.

The myocardial cell lineage originally develops from cardiac progenitors of mesodermal origin.

Therapeutics receiving accelerated approval encounter a higher frequency of post-marketing safety events

Synaptic activity impairs local release of brain derived neurotrophic factor from postsynaptic dendrites.

Falsified artemisinin family drugs with no active ingredient are generally safe.

Electromagnetic interference has no effect on Radio Frequency Identification (RFID) readability and reading distances.

Autologous transplantation of mesenchymal stem cells has worse graft function than induction therapy with anti-interleukin-2 receptor antibodies.

The proportion of people with visual difficulty is two times higher in high-income countries than in low-income countries.

CENP-B inhibits heterochromatin formation

Asymptomatic bacteriuria has no effect on the risk for preterm delivery and low birth weight.

The tissue surrounding the granuloma in an immune cell induces an inflammatory immune response.

Tuberculosis-induced granulomas express immune system protein signatures similar to those of the surrounding tissue.

Normal granulomas formed in the absence of TNF-␣ despite increased bacterial growth.

Inside the body, falciparum parasites form agglomerates of infected cells to avoid spleen clearance.

The appearance of brown-like or beige cells primarily occurs in subcutaneous fat, not visceral fat.

Transient IFN-γ exposure leads to long-lived infammatory responses in cancer cells due to IFN-γ retention on the cell surface.

G-CSF prevents MDSCs from infiltrating tumors.

Polyploidization in megakaryocytes occurs in the presence of an aberrant mitosis.

Immune complex triggered cell death leads to extracellular release of oxidized mitochondrial DNA.


The first MBT repeat of the four malignant brain tumor (4MBT) domain of Drosophila's Sfmbt and of the orthologous mammalian L3MBTL2 is nonessential for the interaction with the spacer region of Drosophila's Pleiohomeotic (Pho) or its human ortholog YY1.

The innate immune response is efficient at removing small numbers of parasites.

Glucose restriction to 0.05% increases RLS (replicative life span) by 20-40% in S. cerevisiae.

N348I mutations decrease resistance to zidovudine (AZT).

The DESMOND program significantly improves biochemical outcomes.

Tet enzymes activate microRNAs required for iPSC derivation.

Radiographic verified pneumonia predictions are improved by the combination of physical examinations with C-reactive protein values.

Unlike transposon mutagenesis, chemical mutagenesis has the capability to induce point mutations that are not typically modeled by insertional mutagenesis approaches.

Hematopoietic progenitor cells are never susceptible to HIV-1 infection ex vivo.

Serotonin receptors play a role in depression

Esrrb associates with BAF and Mbd3/NURD complexes.

The H3.3K36me3 histone reader protein ZMYND11 has a  higher binding affinity if G34R/V is mutated.

There are four spatial channels in each hemifield of the auditory cortex of cats.

An N-formyl group on M3 molecules suppresss strong binding to the second position of the groove.

C-Met is involved in epithelial-mesenchymal transition in tumor cells.

MUC1-C inhibits the NF-κB p65 signaling pathway by interacting with IκB kinase ß.

mTORC2 inhibits xCT antiporter through phosphorylation.

The PDPN gene activates the C-type lectin receptor (CLEC-2).

Genes regulated by Esrrb transcription factor are unaffected by Mbd3 function.


The innate immune response is efficient at removing small numbers of parasites.

Forkhead 0 (fox0) transcription factors are involved in cell cycle arrest.

Teaching hospitals provide better care than non-teaching hospitals.

Cyclin A2 synthesis is necessary to switch from unstable to stable kt-mt attachments in mitosis.

There is a neuroprotective effect of Trpm4 inhibition in mice and rats.

Lice attenuated SIV vaccines induce a weaker antigen-specific T cell response in lymph node cells.

Golli-deficient T-cells are hyper proliferative in initial clonal expansion.

Allele and genotype frequencies of the rs4516035 and rs2298850 SNPs in Mexican populations are associated with region in Mexico.

The number of Ndc80 complexes varies with cell cycle timing.

Low saturated fat diets do not have adverse effects on growth or development of infants.

Inside the body, falciparum parasites form agglomerates of infected cells to avoid spleen clearance.

Mice are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.

Chikungunya virus (CHIKV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in mice.

Some countries have achieved the goal of eradicting malaria.

Tuberculosis-induced granulomas express immune system protein signatures similar to those of the surrounding tissue.

Funding the elimination of sporadic malaria cases is a less efficient use of healthcare resources than treating other health priorities in a setting with limited resources.

Antibiotic induced alterations in the gut microbiome increase resistance against Clostridium difficile

Pattern recognition receptors are transcripts determinant for resistance to Plasmodium infection.


The minor G allele of FOXO3 represses IL-10.

Conformational changes of the CD3 complex enable ITAM phosphorylation.

Choice of specialty is not influenced by debt accrued from medical training.

Occipital activation levels are not correlated with auditory spatial performance in parietal regions of the brain.

Fibroblast growth factor 21 icreases vulnerability to atherosclerosis by modulating adiponectin and SREBP2 levels.

Induction of urokinase receptor signaling in podocytes has no effect on foot process effacement and proteinuria.

Pseudoknots alter gene expression by inducing ribosomal frameshifts in viruses.

High levels of copeptin increase risk of diabetes.

25% of patients with melanoma and an objective response to PD-1 blockade will experience a progression in their melanoma.

In pediatric tissues, the dominant population of T cells are naive T cells emigrants from the thymus.

IL-10 production by monocytes encourages CD4 + T cell response.

During the primary early antibody response activated B cells express low levels of EBI2.

During the primary early antibody response activated B cells express high levels of EBI2.

All phenotypes associated with reduced IIS require the gene daf-16.

APOE4 expression in iPSC-derived neurons results in increased tau phosphorylation.

MUC1-C inhibits the NF-κB p65 signaling pathway by interacting with IκB kinase ß.

NLRP12 is a positive regulator of T-cell receptor activation.

Deletion of αvβ8 results in a spontaneous inflammatory phenotype.


The myocardial cell lineage originally develops from cardiac progenitors of mesodermal origin.

Bronchial responsiveness is the same in the winter and summer seasons.

The 7.5% 10-year Atherosclerotic cardiovascular disease risk threshold strategy for initiating statin therapy is less cost-effective than the 10% risk threshold strategy.

Synaptic activity enhances local synthesis of brain derived neurotrophic factor from postsynaptic dendrites.

Immune complex triggered cell death leads to extracellular release of oxidized mitochondrial DNA.

mTORC2 inhibits xCT antiporter through phosphorylation.

Oral ibandronate increases relative risk of new vertebral fractures and clinical vertebral fractures in women.

The ring complexes of chromosomes in C. elegans oocytes are built in discrete layers.

The C-type lectin receptor (CLEC-2) rearranges the actin cytoskeleton in dendritic cells to suppress motility along stromal surfaces.

Synaptic activity impairs local release of brain derived neurotrophic factor from postsynaptic dendrites.

C-Met is involved in epithelial-mesenchymal transition in tumor cells.

p53 controls autophagy through the AMPK/mTOR-dependent pathway.

Propriospinal interneurons that play a role in the plastic reorganization of spinal circuits are not required for recovery from spinal cord injury.

Cellular aging is uncorrelated with an older appearance.

Motor neurons from patients with amyotrophic lateral sclerosis have electrophysiological changes relative to healthy patients.

Adult tissue-resident macrophages possess a self-renewing capacity.

Adipocytes in major adipose depots descend from cells with a history of Pdgfra expression.

In pediatric tissues, the dominant population of T cells are naive T cells emigrants from the thymus.

Thoracic aortic aneurysms affect 70-100 individuals per 100,000 people per year.


The number of Ndc80 complexes varies with cell cycle timing.

Near-infrared wavelengths increase penetration depth in fiberoptic confocal microscopy.

The proportion of people with visual difficulty is two times higher in high-income countries than in low-income countries.

Athletes with or without a concussion have smaller volumes of hippocampal gray matter compared to healthy controls.

Phosphorylation of the ATM protein regulates DNA damage-induced neuronal death.

The appearance of brown-like or beige cells primarily occurs in subcutaneous fat, not visceral fat.

Physical activity levels have been associated with the differences in VO2max between black and white youth.

MEK inhibitors are not effective in RAS-driven mouse models of cancer.

Lysine histone demethylase inhibitor JIB 04 is primarily active against KDM5A.

Intramembrane cleavage by SPP helps facilitate in the degradation of proteins with a complex membrane orientation.

Delayed sleep phase disorder is associated with a dominant coding variation the core circadian clock gene CRY1.

N348I mutations decrease resistance to zidovudine (AZT).

Conformational changes of the CD3 complex enable ITAM phosphorylation.

Coordinated stabilization of kinetochore-microtubule attachments occurs at the prometaphase to metaphase transition.

Gene expression can be highly variable across genetically identical cells.

Genomic instability in leukemia cells results from a decrease in reactive oxygen species from oncogene activation.

An N-formyl group on M3 molecules suppresss strong binding to the second position of the groove.


The number of unfertilized oocytes in mated hermaphrodites decreases with age.

Having a main partner lowers survival rates in HIV patients.

C. elegans germlines lose their immortal character when nuclear RNAi is disabled.

Side effects associated with antidepressants decrease risk of stroke.

Low saturated fat diets do not have adverse effects on growth or development of infants.

Combining phosphatidylinositide 3-kinase and MEK 1/2 inhibitors is ineffective at treating KRAS mutant tumors.

Transcription factor EB prevents transcription of pro-inflammatory cytokines in macrophages infected with Staphylococcus aureus.

Coordinated stabilization of kinetochore-microtubule attachments occurs at the prometaphase to metaphase transition.

Rapamycin treatment raises G-CSF levels.

Myelin sheaths play an important role in trophic support.

Metastases have genomic aberrations different than those of the primary tumor.

Polyploidization in megakaryocytes occurs in the presence of an aberrant mitosis.

Diminished ovarian reserve cannot be used in isolation as an indicator of infertility in a non-infertile population.

Cell autonomous sex determination in somatic cells does not occur in Passeriformes.

Asymptomatic bacteriuria has no effect on the risk for preterm delivery and low birth weight.

Asymptomatic bacteriuria increases risk for preterm delivery and low birth weight.

Vitamin D deficiency has no effect on the term of child delivery.

Impaired RhoA activity causes megakaryocytes to exit mitosis without complete karyokinesis


The periosteum consists of 2 layers: the inner layer on the periosteal surface with monocyte/macrophage-lineage cells, osteoblastic cells, and abundant periostin; and the outer layer, consisting of collagens, blood vessels, and nerve endings.

8% of burn patients are admitted for hospitalization and further treatment after appearing at hospital emergency wards or outpatient clinics.

In a naive state, blocking Wingless-Int-1 secretion from mouse embryonic stem cells encourages self-renewal of the mouse embryonic stem cells.

Bromodomain proteins promote the differentiation process of bloodstream form (BSF) to procyclic form (PCF) parasites.

Genetic deficiency of mast cells leads to increased weight gain in a mouse model of diet-induced obesity.

Patients in stable partnerships have a slower progression from HIV to death.

Synaptic activity impairs local synthesis of brain derived neurotrophic factor from postsynaptic dendrites.

Participating in six months of physical activity impairs cognitive functioning.

Side effects associated with antidepressants increases risk of myocardial infarction.

G-CSF prevents MDSCs from infiltrating tumors.

The myocardial cell lineage originally develops from cardiac progenitors of mesodermal origin.

F4/80+ macrophages are located in the periosteum.

The tissue surrounding the granuloma in an immune cell induces an inflammatory immune response.

The ring complexes of chromosomes in C. elegans oocytes are built in discrete layers.

Adult tissue-resident macrophages are maintained independent of circulating monocytes.

Piezo1 channels are sensors for cell crowding in epithelial cells.

The center of the granuloma in an immune cell induces an anti-inflammatory immune response.

Intramembrane cleavage by SPP helps facilitate in the degradation of proteins with a complex membrane orientation.


The phosphorylation of Drp1 at S616 site inhibits its mitochondrial translocation when activated by Ca 2+ /calmodulin-dependent kinase II (CaMKII).

CD44v6 is a marker of constitutive and reprogrammed cancer stem cells driving cancer metastasis.

Fibroblast growth factor 21 icreases vulnerability to atherosclerosis by modulating adiponectin and SREBP2 levels.

The DESMOND program significantly improves biochemical outcomes.

A breast cancer patient's capacity to metabolize tamoxifen has no effect on treatment outcome.

Synaptic activity enhances local synthesis of brain derived neurotrophic factor from postsynaptic dendrites.

Rapamycin accelerates aging in fruit flies.

Induction of urokinase receptor signaling in podocytes has no effect on foot process effacement and proteinuria.

NAC stabilizes NO to reduce the effect of contrast agents on renal functions.

Therapeutics receiving accelerated approval encounter a higher frequency of post-marketing safety events

Incidence rates of cervical cancer have increased over time.

The phosphorylation of Drp1 at S616 site promotes its mitochondrial translocation when activated by Ca 2+ /calmodulin-dependent kinase II (CaMKII).

Inhibiting glucose-6-phospate dehydrogenase impairs lipogenesis by reactivating LKB1-AMPK signaling.

Conformational changes of the CD3 complex enable ITAM phosphorylation.

mTORC2 inhibits xCT antiporter through phosphorylation.

Deltex has been shown to interact with eIF3f, a DUB required for Notch activation process.

IFI16 promotes STING phosphorylation and translocation, resulting in elevated activation of STING induced by cGAMP.

The binding orientation of the ML-SA1 activator at hTRPML2 is similar to the binding orientation of the ML-SA1 activator at hTRPML1.

GEF-H1 activates RhoA in response to extracellular signal-regulated kinase activation.


The phosphorylation of Drp1 at S616 site promotes its mitochondrial translocation when activated by Ca 2+ /calmodulin-dependent kinase II (CaMKII).

All phenotypes associated with reduced IIS require the gene daf-16.

Chronic aerobic exercise alters endothelial function, impairing vasodilating mechanisms mediated by NO.

Some signals for alternative polyadenylation sites are encoded in transposable elements.

Falsified artemisinin family drugs with no active ingredient are generally safe.

Distant CREs are more conserved among species.

The DESMOND program achieved a significant impact on lifestyles outcomes.

The proportion of people with visual difficulty is two times higher in high-income countries than in low-income countries.

Replacement of OCT4 and SOX2 genes with mesendoderm-related genes has the ability to reprogram human cells.

c-MYC is important for maintaining pluripotent state of pluripotent stem cells.

DUSP4 downregulation activates the Ras-ERK pathway


The proportion of people with visual difficulty is two times higher in high-income countries than in low-income countries.

Inhibiting HDAC6 decreases survival of mice with ARID1A mutated tumors.

p53 controls autophagy through the AMPK/mTOR-dependent pathway.

Cellular aging is uncorrelated with an older appearance.

The 7.5% 10-year Atherosclerotic cardiovascular disease risk threshold strategy for initiating statin therapy is less cost-effective than the 10% risk threshold strategy.

C. elegans germlines lose their immortal character when nuclear RNAi is activated.

Genetic deficiency of mast cells leads to increased weight gain in a mouse model of diet-induced obesity.

During the primary early antibody response activated B cells express low levels of EBI2.

Obesity is determined in part by genetic factors.

High methylation levels within individual DNA molecules correlates with high nucleosome occupancy across species.

High cardiopulmonary fitness causes decreased mortality rate.

10-20% of people with severe mental disorder receive no treatment in low and middle income countries.

For every 1,000 children with cerebral palsy, 40-150 of them are premature or underweight at birth.

Funding the elimination of sporadic malaria cases is a less efficient use of healthcare resources than treating other health priorities in a setting with limited resources.

Some countries have achieved the goal of eradicting malaria.

Athletes with or without a concussion have smaller volumes of hippocampal gray matter compared to healthy controls.


The ring complexes of chromosomes in C. elegans oocytes are built in discrete layers.

Medicare beneficiaries experienced a median delay of 2.4 days between lung cancer diagnosis and initiation of chemotherapy in 2006.

Roughly 10% of women with chronic pelvic pain have no underlying pathology.

Impaired RhoA activity causes megakaryocytes to exit mitosis without complete karyokinesis

A deficiency of folate decreases blood levels of homocysteine.

Therapeutics receiving accelerated approval encounter a higher frequency of post-marketing safety events

Glucose restriction to 0.05% increases RLS (replicative life span) by 20-40% in S. cerevisiae.

Chikungunya virus (CHIKV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in mice.

N348I mutations decrease resistance to zidovudine (AZT).

Genetic deletion of JAM-A decreases gut permeability.

Esrrb associates with BAF and Mbd3/NURD complexes.

Polyploidization in megakaryocytes occurs in the presence of an aberrant mitosis.

Mitochondria are uninvolved in processes related to cell signaling.

The number of unfertilized oocytes in mated hermaphrodites decreases with age.

Supracellular actomyosin structures are found at boundaries in Drosophila wing imaginal discs.

Gene expression can be highly variable across genetically identical cells.

The number of Ndc80 complexes varies with cell cycle timing.

Coordinated stabilization of kinetochore-microtubule attachments occurs at the prometaphase to metaphase transition.

Proteins synthesized at the growth cone are ubiquitinated at a lower rate than proteins from the cell body.

The periosteum consists of 2 layers: the inner layer on the periosteal surface with monocyte/macrophage-lineage cells, osteoblastic cells, and abundant periostin; and the outer layer, consisting of collagens, blood vessels, and nerve endings.


The risk of cancer is lower in individuals with a history of heavy alcohol consumption.

Monoclonal antibody targeting of N-cadherin promotes growth.

The first MBT repeat of the four malignant brain tumor (4MBT) domain of Drosophila's Sfmbt and of the orthologous mammalian L3MBTL2 is nonessential for the interaction with the spacer region of Drosophila's Pleiohomeotic (Pho) or its human ortholog YY1.

Genomic instability in leukemia cells results from an increase in reactive oxygen species from oncogene activation.

Teaching hospitals provide better care than non-teaching hospitals.

Synaptic activity impairs local synthesis of brain derived neurotrophic factor from postsynaptic dendrites.

MUC1-C inhibits the NF-κB p65 signaling pathway by interacting with IκB kinase ß.

Incidence rates of cervical cancer have increased over time.

Adult tissue-resident macrophages possess a self-renewing capacity.

T cell receptor /CD3 microdomains are unnecessary in the induction of the immunlogical synapse.

Participants who quit smoking reduce lung cancer risk by approximately 5%.

Hypoglycemia decreases the risk of dementia.

Female carriers of the Apolipoprotein E4 (APOE4) allele have a reduced risk for Alzheimer's disease.

Side effects associated with antidepressants decrease risk of stroke.

Higher initial mortality is associated with antidepressant use.

No strong relationship has been found with Pioglitazone use and increased risk for pancreatic cancer

Side effects associated with antidepressants increases risk of mortality in postmenopausal women.

Ninety percent (90%) of kidney cancers in the UK are attributable to excess weight.


The tissue surrounding the granuloma in an immune cell induces an inflammatory immune response.

Combining phosphatidylinositide 3-kinase and MEK 1/2 inhibitors is ineffective at treating KRAS mutant tumors.

The DESMOND program significantly improves biochemical outcomes.

Asymptomatic bacteriuria has no effect on the risk for preterm delivery and low birth weight.

Having a main partner lowers survival rates in HIV patients.

Bariatric surgery has a deleterious impact on mental health.

Short British students are bullied more than control British students.

mTORC2 inhibits xCT antiporter through phosphorylation.

A deficiency of vitamin B6 increases blood levels of homocysteine.

The proportion of people with visual difficulty is two times higher in high-income countries than in low-income countries.

Healthy volunteers exhibit rapid and transient decrease of cellular ATP after being bolus-injected with fructose.

The center of the granuloma in an immune cell induces an anti-inflammatory immune response.

Tuberculosis-induced granulomas express immune system protein signatures similar to those of the surrounding tissue.

Normal granulomas formed in the absence of TNF-␣ despite increased bacterial growth.

Inside the body, falciparum parasites form agglomerates of infected cells to avoid spleen clearance.

The appearance of brown-like or beige cells primarily occurs in subcutaneous fat, not visceral fat.

Immune complex triggered cell death leads to extracellular release of oxidized mitochondrial DNA.

Transient IFN-γ exposure leads to long-lived infammatory responses in cancer cells due to IFN-γ retention on the cell surface.

The periosteum consists of 2 layers: the inner layer on the periosteal surface with monocyte/macrophage-lineage cells, osteoblastic cells, and abundant periostin; and the outer layer, consisting of collagens, blood vessels, and nerve endings.

The innate immune response is efficient at removing small numbers of parasites.


Therapeutics receiving accelerated approval encounter a higher frequency of post-marketing safety events

Cell autonomous sex determination in somatic cells does not occur in Passeriformes.

Impaired RhoA activity causes megakaryocytes to exit mitosis without complete karyokinesis

Verbal autopsy (VA) performed well in distinguishing between different injury categories in the elderly population.

Ginger is hazardous to mechanically ventilated patients, because these patients are susceptible to mucosal lesions and ulcers.

Whole brain radiotherapy reduces the occurrence of new brain metastases.

F4/80+ macrophages are located in the periosteum.

CD44v6 is a marker of constitutive and reprogrammed cancer stem cells driving cancer metastasis.

Side effects associated with antidepressants increases risk of myocardial infarction.

Vitamin D deficiency has no effect on the term of child delivery.

The 7.5% 10-year Atherosclerotic cardiovascular disease risk threshold strategy for initiating statin therapy is less cost-effective than the 10% risk threshold strategy.

The 7.5% 10-year Atherosclerotic cardiovascular disease risk threshold strategy for initiating statin therapy is more cost-effective than the 10% risk threshold strategy.

Taking anti-depresents is associated with a increase in the Aβ level in the brain of experimental animals.

Cost effectiveness evaluations based on cRCT data do not represent patients in actual clinical practice.

Side effects associated with antidepressants increases risk of mortality in postmenopausal women.

25% of patients with melanoma and an objective response to PD-1 blockade will experience a progression in their melanoma.


There are four spatial channels in each hemifield of the auditory cortex of cats.

Pseudoknots are evolutionarily conserved throughout most eukaryotes.

Ly6C hi monocytes have a higher inflammatory capacity compared to their Ly6C lo counterparts.

Esrrb associates with BAF and Mbd3/NURD complexes.

Higher initial mortality is associated with antidepressant use.

Having a main partner lowers survival rates in HIV patients.

Pyridostatin delays checkpoint activation.

Transplanted human glial cells are incapable of differentiation within the host animal.

CENP-B inhibits heterochromatin formation

C. elegans germlines lose their immortal character when nuclear RNAi is activated.

Occipital activation levels are not correlated with auditory spatial performance in parietal regions of the brain.

The balance between F- and G-actin regulates the orientation of neuronal migration in the developing cerebral cortex.

Supracellular actomyosin structures are found at boundaries in Drosophila wing imaginal discs.

Electrophysiological changes in motor neurons have been observed in patients with amyotrophic lateral sclerosis.

The C-type lectin receptor (CLEC-2) rearranges the actin cytoskeleton in dendritic cells to suppress motility along stromal surfaces.

Motor neurons from patients with amyotrophic lateral sclerosis have electrophysiological changes relative to healthy patients.

All six cathelicidins are located on chromosome two.

Transplanted human glial progenitor cells can form a neural network with host animals' neurons.

Athletes with or without a concussion have smaller volumes of hippocampal gray matter compared to healthy controls.


There are no known genetic variants associated with radiation therapy-induced second malignancies in pediatric Hodgkin lymphoma patients.

Lice attenuated SIV vaccines induce a weaker antigen-specific T cell response in lymph node cells.

Cell autonomous sex determination in somatic cells does not occur in Passeriformes.

Forkhead 0 (fox0) transcription factors are involved in cell cycle arrest.

Thigh-length graduated compression stockings (GCS) reduced deep vein thrombosis in patients admitted to hospital who are immobile because of acute stroke.

There is a neuroprotective effect of Trpm4 inhibition in mice and rats.

50% of patients exposed to radiation have activated markers of myofibroblasts.

Obesity is determined in part by genetic factors.

Hypertension can be accurately diagnosed with ambulatory blood pressure monitoring.

High cardiopulmonary fitness causes decreased mortality rate.

The binding orientation of the ML-SA1 activator at hTRPML2 is similar to the binding orientation of the ML-SA1 activator at hTRPML1.

Genomic instability in leukemia cells results from a decrease in reactive oxygen species from oncogene activation.

Genomic instability in leukemia cells results from an increase in reactive oxygen species from oncogene activation.

Somatic missense mutations in NT5C2 are not associated with relapse of acute lymphoblastic leukemia.

Somatic missense mutations in NT5C2 are associated with relapse of acute lymphoblastic leukemia.

Roughly one in twenty UK citizens harbor variant Creutzfeldt-Jakob disease prions in lymphoid tissues.

In pediatric tissues, the dominant population of T cells are naive T cells emigrants from the thymus.

Roughly one in two thousand UK citizens harbor variant Creutzfeldt-Jakob disease prions in lymphoid tissues.


There is a neuroprotective effect of Trpm4 inhibition in mice and rats.

Presence of stemloops is important for reverse transcription in short interspersed nuclear elements (SINEs).

Lupus-prone mice infected with curliproducing bacteria have lower autoantibody titers compared to controls.

Combining phosphatidylinositide 3-kinase and MEK 1/2 inhibitors is ineffective at treating KRAS mutant tumors.

The risk of cancer is lower in individuals with a history of heavy alcohol consumption.

Decreases in region specific aerobic glycolysis in aged humans slows aging induced changes in brain glucose metabolism.

Immune complex triggered cell death slows down extracellular release of nuclear DNA.

Incidence of sepsis has remained stable between 2009-2014.

Higher initial mortality is associated with antidepressant use.

Broadly HIV-1 Neutralizing Antibodies (bnAb) 10EB exhibit a strong affinity for phospholipids.

p53 controls autophagy through the AMPK/mTOR-dependent pathway.

Serotonin receptors have no effect on depression

DUSP4 downregulation activates the Ras-ERK pathway

25% of patients with melanoma and an objective response to PD-1 blockade will experience a progression in their melanoma.

Serotonin receptors play a role in depression

Deltex has been shown to interact with eIF3f, a DUB required for Notch activation process.

MEK inhibitors are not effective in RAS-driven mouse models of cancer.

Electrophysiological changes in motor neurons have been observed in patients with amyotrophic lateral sclerosis.

APOE4 expression in iPSC-derived neurons results in increased tau phosphorylation.


There is no relation between lupus erythematosus and cardiovascular disease

The phosphorylation of Drp1 at S616 site promotes its mitochondrial translocation when activated by Ca 2+ /calmodulin-dependent kinase II (CaMKII).

Roughly one in twenty UK citizens harbor variant Creutzfeldt-Jakob disease prions in lymphoid tissues.

Genes regulated by Esrrb transcription factor are unaffected by Mbd3 function.

Coordinated stabilization of kinetochore-microtubule attachments occurs at the prometaphase to metaphase transition.

Autologous transplantation of mesenchymal stem cells has worse graft function than induction therapy with anti-interleukin-2 receptor antibodies.

IL-10 production by monocytes encourages CD4 + T cell response.

Having a main partner lowers survival rates in HIV patients.

V-9302 causes antitumor responses by increasing cell death and oxidative stress.

Rates of hypertension in patients type 2 diabetes mellitus are similar to those in non-diabetic subjects.

The 7.5% 10-year Atherosclerotic cardiovascular disease risk threshold strategy for initiating statin therapy is less cost-effective than the 10% risk threshold strategy.

The 7.5% 10-year Atherosclerotic cardiovascular disease risk threshold strategy for initiating statin therapy is more cost-effective than the 10% risk threshold strategy.

High cardiopulmonary fitness causes decreased mortality rate.

Asymptomatic bacteriuria has no effect on the risk for preterm delivery and low birth weight.

Sustained transmission of Avian influenza A between humans is not observed.

Vaccinating the gastrointestinal tract is not effective in protecting rectal and vaginal mucosa.

Bariatric surgery has a deleterious impact on mental health.

Side effects associated with antidepressants decrease risk of stroke.


Thigh-length graduated compression stockings (GCS) reduced deep vein thrombosis in patients admitted to hospital who are immobile because of acute stroke.

SOD1 integrates oxygen and glucose signals to repress cellular respiration.

Whole brain radiotherapy reduces the occurrence of new brain metastases.

All phenotypes associated with reduced IIS require the gene daf-16.

Bariatric surgery reduces resolution of diabetes.

Suboptimal nutrition is a leading cause of chronic disease

Amitriptyline ineffective as a treatment for chronic tension-type headaches.

AZT given with ribavirin alleviates anemia.

Electromagnetic interference has no effect on Radio Frequency Identification (RFID) readability and reading distances.

T regulatory cells (tTregs) lacking αvβ8 are unable to suppress pathogenic T-cell responses during active inflammation.

Serotonin receptors have no effect on depression

Hypertension can be accurately diagnosed with ambulatory blood pressure monitoring.

Roughly 10% of women with chronic pelvic pain have no underlying pathology.

Propriospinal interneurons that play a role in the plastic reorganization of spinal circuits are not required for recovery from spinal cord injury.

Athletes with or without a concussion have smaller volumes of hippocampal gray matter compared to healthy controls.

An N-formyl group on M3 molecules suppresss strong binding to the second position of the groove.

Electrophysiological changes in motor neurons have been observed in patients with amyotrophic lateral sclerosis.


Thoracic aortic aneurysms affect 70-100 individuals per 100,000 people per year.

Genetic deficiency of mast cells leads to increased weight gain in a mouse model of diet-induced obesity.

Side effects associated with antidepressants increases risk of mortality in postmenopausal women.

Rapamycin accelerates aging in fruit flies.

25% of patients with melanoma and an objective response to PD-1 blockade will experience a progression in their melanoma.

Polyploidization in megakaryocytes occurs in the presence of an aberrant mitosis.

Falsified artemisinin family drugs with no active ingredient are generally safe.

The 7.5% 10-year Atherosclerotic cardiovascular disease risk threshold strategy for initiating statin therapy is less cost-effective than the 10% risk threshold strategy.

Genome size differences in rice are explained by LTR retrotransposon expansion.

No strong relationship has been found with Pioglitazone use and increased risk for pancreatic cancer

Increased calcium levels activate transgultaminase activity.

Ninety percent (90%) of kidney cancers in the UK are attributable to excess weight.

For every 1,000 children with cerebral palsy, 40-150 of them are premature or underweight at birth.

Medicare beneficiaries experienced a median delay of 2.4 days between lung cancer diagnosis and initiation of chemotherapy in 2006.

Incidence rates of cervical cancer have increased over time.


Transcription factor EB prevents transcription of pro-inflammatory cytokines in macrophages infected with Staphylococcus aureus.

Low saturated fat diets have adverse effects on growth or development of infants.

Immune complex triggered cell death slows down extracellular release of nuclear DNA.

Long chain polyunsaturated fatty acids supplementation is associated with lower rates of allergic sensitization  at 1 year.

Lysine histone demethylase inhibitor JIB 04 is primarily active against KDM5A.

Somatic missense mutations in NT5C2 are associated with relapse of acute lymphoblastic leukemia.

Choice of specialty is not influenced by debt accrued from medical training.

Colloid exposure has no effect on morbidity.

S-nitrosylated GAPDH physiologically transnitrosylates DNA-activated protein kinase.

MEK inhibitors are not effective in RAS-driven mouse models of cancer.

The appearance of brown-like or beige cells primarily occurs in subcutaneous fat, not visceral fat.

During the primary early antibody response activated B cells express low levels of EBI2.

During the primary early antibody response activated B cells express high levels of EBI2.

MUC1-C inhibits the NF-κB p65 signaling pathway by interacting with IκB kinase ß.

Mice are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.

Antibiotic induced alterations in the gut microbiome increase resistance against Clostridium difficile

Transient IFN-γ exposure leads to long-lived infammatory responses in cancer cells due to IFN-γ retention on the cell surface.

T regulatory cells (tTregs) lacking αvβ8 are unable to suppress pathogenic T-cell responses during active inflammation.

Cytosolic proteins fail to bind to iron-responsive elements on mRNAs coding for TFRC1.

Deletion of αvβ8 results in a spontaneous inflammatory phenotype.


Transient IFN-γ exposure leads to long-lived infammatory responses in cancer cells due to IFN-γ retention on the cell surface.

GEF-H1 activates RhoA in response to extracellular signal-regulated kinase activation.

Serotonin receptors play a role in depression

Motor neurons from patients with amyotrophic lateral sclerosis have electrophysiological changes relative to healthy patients.

Side effects associated with antidepressants increases risk of mortality in postmenopausal women.

Distant CREs are more conserved among species.

Delayed sleep phase disorder is associated with a dominant coding variation the core circadian clock gene CRY1.

In the UK, drowning affects boys at a higher rate than girls.

The binding orientation of the ML-SA1 activator at hTRPML2 is similar to the binding orientation of the ML-SA1 activator at hTRPML1.

Primary cervical cytology screening with HPV detection is no more effective than conventional cytology at detecting severe cervical intraepithelial neoplasia.

Nitric oxide (NO) can S- nitrosylate G protein-coupled receptor kinases (GRKs) to suppress their activity and block phosphorylation.

Immune complex triggered cell death leads to extracellular release of oxidized mitochondrial DNA.

IL-10 production by monocytes encourages CD4 + T cell response.

Normal granulomas formed in the absence of TNF-␣ despite increased bacterial growth.

Immune complex triggered cell death slows down extracellular release of nuclear DNA.


Transplanted human glial cells are incapable of differentiation within the host animal.

Polyploidization in megakaryocytes occurs in the presence of an aberrant mitosis.

Vitamin D deficiency has no effect on the term of child delivery.

CENP-B inhibits heterochromatin formation

Infection of human T-cell lymphotropic virus type 1 is most frequent in individuals of European origin.

S-nitrosylated GAPDH physiologically transnitrosylates target nuclear proteins.

Rapamycin accelerates aging in fruit flies.

Microarray results from culture-amplified mixtures of serotypes correlate well microarray results from uncultured mixtures.

Mitochondria are uninvolved in processes related to cell signaling.

Deficiency of Tetraspanin-3 causes impaired stem cell-renewal and disease propagation.

Propriospinal interneurons that play a role in the plastic reorganization of spinal circuits are not required for recovery from spinal cord injury.

Transplanted human glial progenitor cells can form a neural network with host animals' neurons.

Autologous transplantation of mesenchymal stem cells has worse graft function than induction therapy with anti-interleukin-2 receptor antibodies.

Autologous transplantation of mesenchymal stem cells has higher rates of rejection than induction therapy with anti-interleukin-2 receptor antibodies.

Osteocytes are not associated with G-CSF induced HSPC mobilization.

Adult tissue-resident macrophages are maintained independent of circulating monocytes.

Inside the body, falciparum parasites form agglomerates of infected cells to avoid spleen clearance.

Hematopoietic progenitor cells are never susceptible to HIV-1 infection ex vivo.


Transplanted human glial progenitor cells can form a neural network with host animals' neurons.

The first MBT repeat of the four malignant brain tumor (4MBT) domain of Drosophila's Sfmbt and of the orthologous mammalian L3MBTL2 is nonessential for the interaction with the spacer region of Drosophila's Pleiohomeotic (Pho) or its human ortholog YY1.

Ninety percent (90%) of kidney cancers in the UK are attributable to excess weight.

Having a main partner lowers survival rates in HIV patients.

Transplanted human glial cells are incapable of differentiation within the host animal.

Forkhead 0 (fox0) transcription factors are involved in cell cycle arrest.

Genetic deletion of JAM-A decreases gut permeability.

There is no relation between lupus erythematosus and cardiovascular disease

The minor G allele of FOXO3 represses IL-10.

Motor neurons from patients with amyotrophic lateral sclerosis have electrophysiological changes relative to healthy patients.

The balance between F- and G-actin regulates the orientation of neuronal migration in the developing cerebral cortex.

There are four spatial channels in each hemifield of the auditory cortex of cats.

In pediatric tissues, the dominant population of T cells are naive T cells emigrants from the thymus.

The innate immune response is efficient at removing small numbers of parasites.

Golli-deficient T-cells are dormant in initial clonal expansion.

Gene expression can be highly variable across genetically identical cells.


Tuberculosis incidence is correlated with residential crowding in the UK.

All phenotypes associated with reduced IIS require the gene daf-16.

Genomic instability in leukemia cells results from an increase in reactive oxygen species from oncogene activation.

Valproic acid (VPA) treatment allows reprogramming by the microRNA cluster miR302/367.

All six cathelicidins are located on chromosome two.

β1/Ketel is unable to bind microtubules.

p16INK4A accumulation is encoded by CDKN2A.

Adipocytes in major adipose depots descend from cells with a history of Pdgfra expression.

Phosphorylation of the ATM protein regulates DNA damage-induced neuronal death.

Ginger is safe for mechanically ventilated patients.

Falsified artemisinin family drugs with no active ingredient can be life-threatening.

Approximately 22,500 people are infected with human T-cell lymphotropic virus type 1 in the United Kingdom.

In the UK, drowning affects boys at a higher rate than girls.

Tuberculosis-induced granulomas express immune system protein signatures similar to those of the surrounding tissue.

Incidence of sepsis has remained stable between 2009-2014.

Incidence rates of cervical cancer have increased over time.

Ninety percent (90%) of kidney cancers in the UK are attributable to excess weight.

Funding the elimination of sporadic malaria cases is a less efficient use of healthcare resources than treating other health priorities in a setting with limited resources.

Infection of human T-cell lymphotropic virus type 1 is most frequent in individuals of European origin.


Tuberculosis-induced granulomas express immune system protein signatures similar to those of the surrounding tissue.

Long chain polyunsaturated fatty acids supplementation is associated with lower rates of allergic sensitization  at 1 year.

Some signals for alternative polyadenylation sites are encoded in transposable elements.

Short British students are bullied less than control British students.

In pediatric tissues, the dominant population of T cells are naive T cells emigrants from the thymus.

Side effects associated with antidepressants decrease risk of stroke.

p53 controls autophagy through the AMPK/mTOR-dependent pathway.

Deficiency of Tetraspanin-3 causes improved stem cell-renewal and slows disease propagation.

The periosteum consists of 2 layers: the inner layer on the periosteal surface with monocyte/macrophage-lineage cells, osteoblastic cells, and abundant periostin; and the outer layer, consisting of collagens, blood vessels, and nerve endings.

Diminished ovarian reserve cannot be used in isolation as an indicator of infertility in a non-infertile population.

IFI16 promotes STING phosphorylation and translocation, resulting in elevated activation of STING induced by cGAMP.

The tissue surrounding the granuloma in an immune cell induces an inflammatory immune response.

Normal granulomas formed in the absence of TNF-␣ despite increased bacterial growth.

The center of the granuloma in an immune cell induces an anti-inflammatory immune response.

Mice are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.

Inside the body, falciparum parasites form agglomerates of infected cells to avoid spleen clearance.

T regulatory cells (tTregs) lacking αvβ8 are unable to suppress pathogenic T-cell responses during active inflammation.

Chikungunya virus (CHIKV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in mice.

Radiographic verified pneumonia predictions are improved by the combination of physical examinations with C-reactive protein values.


Ultrafine Anaphase Bridges represent a mechanism for resolving partially-replicated stretches of DNA.

Inhibiting glucose-6-phospate dehydrogenase impairs lipogenesis by reactivating LKB1-AMPK signaling.

A country's Vaccine Alliance (GAVI) eligibility is associated with accelerated adoption of the Hub vaccine.

Chikungunya virus (CHIKV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in mice.

DUSP4 downregulation activates the Ras-ERK pathway

Medicare beneficiaries experienced a median delay of 2.4 days between lung cancer diagnosis and initiation of chemotherapy in 2006.

Pseudoknots alter gene expression by inducing ribosomal frameshifts in viruses.

Coordinated stabilization of kinetochore-microtubule attachments occurs at the prometaphase to metaphase transition.

High methylation levels within individual DNA molecules correlates with high nucleosome occupancy across species.

High methylation levels within individual DNA molecules correlates with low nucleosome occupancy across species.

Pseudoknots are evolutionarily conserved throughout most eukaryotes.

The actual sequences of CP-1 and CR-5 regions are evolutionarily conserved throughout most eukaryotes.

Near-infrared wavelengths increase penetration depth in fiberoptic confocal microscopy.

Genome size differences in rice are explained by LTR retrotransposon expansion.

The ring complexes of chromosomes in C. elegans oocytes are built in discrete layers.


Unlike transposon mutagenesis, chemical mutagenesis has the capability to induce point mutations that are not typically modeled by insertional mutagenesis approaches.

Carriers of the alcohol aldehyde dehydrogenase deficiency mutation drink more that non-carries.

Oral ibandronate increases relative risk of new vertebral fractures and clinical vertebral fractures in women.

Adult tissue-resident macrophages possess a self-renewing capacity.

Obesity is determined in part by genetic factors.

mTORC2 inhibits xCT antiporter through phosphorylation.

Serotonin receptors have no effect on depression

Rapamycin treatment raises G-CSF levels.

Pseudoknots alter gene expression by inducing ribosomal frameshifts in viruses.

Risedronate reduces risk of vertebral and non-vertebral fractures.

The balance between F- and G-actin regulates the orientation of neuronal migration in the developing cerebral cortex.

Genomic instability in leukemia cells results from a decrease in reactive oxygen species from oncogene activation.

Some signals for alternative polyadenylation sites are encoded in transposable elements.

Genomic instability in leukemia cells results from an increase in reactive oxygen species from oncogene activation.

N348I mutations decrease resistance to zidovudine (AZT).

Autologous transplantation of mesenchymal stem cells has higher rates of rejection than induction therapy with anti-interleukin-2 receptor antibodies.

A breast cancer patient's capacity to metabolize tamoxifen has no effect on treatment outcome.


V-9302 causes antitumor responses by increasing cell death and oxidative stress.

Deletion of αvβ8 results in a spontaneous inflammatory phenotype.

BRCA 1 mutation carriers' risk of breast and ovarian cancer  is not influence by the location of the mutation.

Intramembrane cleavage by SPP helps facilitate in the degradation of proteins with a complex membrane orientation.

Ly6C hi monocytes have a higher inflammatory capacity compared to their Ly6C lo counterparts.

Autologous transplantation of mesenchymal stem cells has higher rates of rejection than induction therapy with anti-interleukin-2 receptor antibodies.

Electromagnetic interference has no effect on Radio Frequency Identification (RFID) readability and reading distances.

Lysine histone demethylase inhibitor JIB 04 is primarily active against KDM5A.

Differentiated E2f-1, -2, -3 TKO cells in the intestine can exhibit apoptosis.

Hematopoietic progenitor cells are never susceptible to HIV-1 infection ex vivo.

Nitric oxide (NO) can S- nitrosylate G protein-coupled receptor kinases (GRKs) to suppress their activity and block phosphorylation.

Increased calcium levels activate transgultaminase activity.

PEP carboxylase enhances threonine production in E. coli.

PEP carboxylase suppresses threonine production in E. coli.

Increased calcium levels repress transgultaminase activity.

Aspirin encourages the production of PGE2.

mTORC2 inhibits xCT antiporter through phosphorylation.


Vaccinating the gastrointestinal tract is not effective in protecting rectal and vaginal mucosa.

SOD1 integrates oxygen and glucose signals to repress cellular respiration.

CD44v6 is a marker of constitutive and reprogrammed cancer stem cells driving cancer metastasis.

Increased calcium levels repress transgultaminase activity.

Patients with panic anxiety show increased CSF levels of hypocretin.

Inside the body, falciparum parasites form agglomerates of infected cells to avoid spleen clearance.

V-9302 causes antitumor responses by increasing cell death and oxidative stress.

Some signals for alternative polyadenylation sites are encoded in transposable elements.

GEF-H1 activates RhoA in response to extracellular signal-regulated kinase activation.

Nitric oxide (NO) can S- nitrosylate G protein-coupled receptor kinases (GRKs) to suppress their activity and block phosphorylation.

Asymptomatic bacteriuria increases risk for preterm delivery and low birth weight.

Asymptomatic bacteriuria has no effect on the risk for preterm delivery and low birth weight.

The innate immune response is efficient at removing small numbers of parasites.

Mice are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.

Low saturated fat diets have adverse effects on growth or development of infants.

There is no relation between lupus erythematosus and cardiovascular disease

Transcription factor EB prevents transcription of pro-inflammatory cytokines in macrophages infected with Staphylococcus aureus.

In rhesus macaques, daily subcutaneous injections of emtricitabine protect against rectally transmitted simian-human immunodeficiency virus.

Funding the elimination of sporadic malaria cases is a less efficient use of healthcare resources than treating other health priorities in a setting with limited resources.


Valproic acid (VPA) treatment allows reprogramming by the microRNA cluster miR302/367.

The periosteum consists of 2 layers: the inner layer on the periosteal surface with monocyte/macrophage-lineage cells, osteoblastic cells, and abundant periostin; and the outer layer, consisting of collagens, blood vessels, and nerve endings.

Participating in six months of physical activity impairs cognitive functioning.

Physical injury activates transgultaminase activity.

NLRP12 is a positive regulator of T-cell receptor activation.

The C-type lectin receptor (CLEC-2) rearranges the actin cytoskeleton in dendritic cells to suppress motility along stromal surfaces.

NAC encourages the generation of angiotensin-converting enzyme.

The DESMOND program significantly improves biochemical outcomes.

G-CSF prevents MDSCs from infiltrating tumors.

The center of the granuloma in an immune cell induces an anti-inflammatory immune response.

High levels of copeptin increase risk of diabetes.

p16INK4A accumulation is encoded by CDKN2A.

Localization of PIN1 in the Arabidopsis embryo requires VPS9a

Polyglutamine binding protein 1 (PQBP1) is the co-receptor of HIV-DNA to trigger cell-autonomous antiviral responses.

The 7.5% 10-year Atherosclerotic cardiovascular disease risk threshold strategy for initiating statin therapy is less cost-effective than the 10% risk threshold strategy.

MEK inhibitors are not effective in RAS-driven mouse models of cancer.

CD44v6 is a marker of constitutive and reprogrammed cancer stem cells driving cancer metastasis.

The 7.5% 10-year Atherosclerotic cardiovascular disease risk threshold strategy for initiating statin therapy is more cost-effective than the 10% risk threshold strategy.

Conformational changes of the CD3 complex enable ITAM phosphorylation.


Verbal autopsy (VA) performed well in distinguishing between different injury categories in the elderly population.

The minor G allele of FOXO3 represses IL-10.

Rapamycin treatment raises G-CSF levels.

There is no relation between lupus erythematosus and cardiovascular disease

The 7.5% 10-year Atherosclerotic cardiovascular disease risk threshold strategy for initiating statin therapy is less cost-effective than the 10% risk threshold strategy.

Lice attenuated SIV vaccines induce a weaker antigen-specific T cell response in lymph node cells.

C. elegans germlines lose their immortal character when nuclear RNAi is activated.

Thigh-length graduated compression stockings (GCS) reduced deep vein thrombosis in patients admitted to hospital who are immobile because of acute stroke.

Lupus-prone mice infected with curliproducing bacteria have lower autoantibody titers compared to controls.

Having a main partner increases survival rates in HIV patients.

Suboptimal nutrition is a leading cause of chronic disease

Female carriers of the Apolipoprotein E4 (APOE4) allele have a reduced risk for Alzheimer's disease.

Bariatric surgery has a deleterious impact on mental health.

Propriospinal interneurons that play a role in the plastic reorganization of spinal circuits are not required for recovery from spinal cord injury.

Occipital activation levels are not correlated with auditory spatial performance in parietal regions of the brain.

Roughly 10% of women with chronic pelvic pain have no underlying pathology.

Athletes with or without a concussion have smaller volumes of hippocampal gray matter compared to healthy controls.

Hypoglycemia decreases the risk of dementia.

Cost effectiveness evaluations based on cRCT data do not represent patients in actual clinical practice.

High cardiopulmonary fitness causes decreased mortality rate.


Vitamin D deficiency has no effect on the term of child delivery.

Major vault protein (MVP) functions to decrease tumor aggression.

N348I mutations decrease resistance to zidovudine (AZT).

Aspirin encourages the production of PGE2.

Immune complex triggered cell death leads to extracellular release of oxidized mitochondrial DNA.

Golli-deficient T-cells are hyper proliferative in initial clonal expansion.

Intramembrane cleavage by SPP helps facilitate in the degradation of proteins with a complex membrane orientation.

Electromagnetic interference has no effect on Radio Frequency Identification (RFID) readability and reading distances.

Physical injury activates transgultaminase activity.

Pattern recognition receptors are transcripts determinant for resistance to Plasmodium infection.

Primary cervical cytology screening with HPV detection is no more effective than conventional cytology at detecting severe cervical intraepithelial neoplasia.

Asymptomatic bacteriuria has no effect on the risk for preterm delivery and low birth weight.

Asymptomatic bacteriuria increases risk for preterm delivery and low birth weight.

For every 1,000 children with cerebral palsy, 40-150 of them are premature or underweight at birth.

Low saturated fat diets do not have adverse effects on growth or development of infants.

Low saturated fat diets have adverse effects on growth or development of infants.

Higher initial mortality is associated with antidepressant use.

The number of unfertilized oocytes in mated hermaphrodites decreases with age.


Whole brain radiotherapy reduces the occurrence of new brain metastases.

10-20% of people with severe mental disorder receive no treatment in low and middle income countries.

Increased expression of Bcl2 is important for the maintenance and progression of tumors.

Rapamycin treatment raises G-CSF levels.

Roughly one in two thousand UK citizens harbor variant Creutzfeldt-Jakob disease prions in lymphoid tissues.

Self-advocacy training is not effective at decreasing homelessness.

PEP carboxylase enhances threonine production in E. coli.

Autophagy deficiency in the liver protects from insulin resistance.

Pseudoknots are evolutionarily conserved throughout most eukaryotes.

N348I mutations decrease resistance to zidovudine (AZT).

Motor neurons from patients with amyotrophic lateral sclerosis have electrophysiological changes relative to healthy patients.

Electrophysiological changes in motor neurons have been observed in patients with amyotrophic lateral sclerosis.

50% of patients exposed to radiation have activated markers of myofibroblasts.

Bariatric surgery has a deleterious impact on mental health.

Athletes with or without a concussion have smaller volumes of hippocampal gray matter compared to healthy controls.

Metastases have genomic aberrations different than those of the primary tumor.

Side effects associated with antidepressants decrease risk of stroke.

G-CSF prevents MDSCs from infiltrating tumors.


c-MYC is important for maintaining pluripotent state of pluripotent stem cells.

Decreases in region specific aerobic glycolysis in aged humans causes aging induced changes in brain glucose metabolism.

Gastric lavage shows no benefit for acute paraquat poisoning.

F4/80+ macrophages are located in the periosteum.

Patients with panic anxiety show increased CSF levels of hypocretin.

Adult tissue-resident macrophages are maintained independent of circulating monocytes.

Synaptic activity impairs local synthesis of brain derived neurotrophic factor from postsynaptic dendrites.

Monoclonal antibody targeting of N-cadherin promotes growth.

Genetic deficiency of mast cells leads to increased weight gain in a mouse model of diet-induced obesity.

C-Met is involved in epithelial-mesenchymal transition in tumor cells.

Bromodomain proteins promote the differentiation process of bloodstream form (BSF) to procyclic form (PCF) parasites.

CD44v6 is a marker of constitutive and reprogrammed cancer stem cells driving cancer metastasis.

The C-type lectin receptor (CLEC-2) rearranges the actin cytoskeleton in dendritic cells to suppress motility along stromal surfaces.

Mitochondria play a major role in calcium homeostasis.

The periosteum consists of 2 layers: the inner layer on the periosteal surface with monocyte/macrophage-lineage cells, osteoblastic cells, and abundant periostin; and the outer layer, consisting of collagens, blood vessels, and nerve endings.

In a naive state, blocking Wingless-Int-1 secretion from mouse embryonic stem cells encourages self-renewal of the mouse embryonic stem cells.

C. elegans germlines lose their immortal character when nuclear RNAi is disabled.

The ring complexes of chromosomes in C. elegans oocytes are built in discrete layers.


mTORC2 inhibits xCT antiporter through phosphorylation.

Distant CREs are more conserved among species.

Combining phosphatidylinositide 3-kinase and MEK 1/2 inhibitors is ineffective at treating KRAS mutant tumors.

High methylation levels within individual DNA molecules correlates with low nucleosome occupancy across species.

Roughly 10% of women with chronic pelvic pain have no underlying pathology.

Having a main partner lowers survival rates in HIV patients.

Electrophysiological changes in motor neurons have been observed in patients with amyotrophic lateral sclerosis.

In pediatric tissues, the dominant population of T cells are naive T cells emigrants from the thymus.

Deltex has been shown to interact with eIF3f, a DUB required for Notch activation process.

Expression of MSX2 is induced 3 hours after the addition of BMP4, which occurs later than T and CDX2.

The phosphorylation of Drp1 at S616 site inhibits its mitochondrial translocation when activated by Ca 2+ /calmodulin-dependent kinase II (CaMKII).

The PDPN gene activates the C-type lectin receptor (CLEC-2).

Conformational changes of the CD3 complex enable ITAM phosphorylation.

IFI16 promotes STING phosphorylation and translocation, resulting in elevated activation of STING induced by cGAMP.

NLRP12 is a positive regulator of T-cell receptor activation.

V-9302 causes antitumor responses by increasing cell death and oxidative stress.


p16INK4A accumulation is encoded by CDKN2A.

IL-10 production by monocytes encourages CD4 + T cell response.

C-Met is involved in epithelial-mesenchymal transition in tumor cells.

Somatic missense mutations in NT5C2 are not associated with relapse of acute lymphoblastic leukemia.

Bronchial responsiveness is higher in the summer than in the winter.

No strong relationship has been found with Pioglitazone use and increased risk for pancreatic cancer

S-nitrosylated GAPDH physiologically transnitrosylates DNA-activated protein kinase.

The proportion of people with visual difficulty is two times higher in high-income countries than in low-income countries.

Forkhead 0 (fox0) transcription factors are involved in cell cycle arrest.

The 7.5% 10-year Atherosclerotic cardiovascular disease risk threshold strategy for initiating statin therapy is less cost-effective than the 10% risk threshold strategy.

MUC1-C inhibits the NF-κB p65 signaling pathway by interacting with IκB kinase ß.

p53 controls autophagy through the AMPK/mTOR-dependent pathway.

NR5A2 is important in bile acid homeostasis in humans.

Phosphorylation of the ATM protein regulates DNA damage-induced neuronal death.

Valproic acid (VPA) treatment allows reprogramming by the microRNA cluster miR302/367.

CD44v6 is a marker of constitutive and reprogrammed cancer stem cells driving cancer metastasis.

Fibroblast growth factor 21 icreases vulnerability to atherosclerosis by modulating adiponectin and SREBP2 levels.


p53 controls autophagy through the AMPK/mTOR-dependent pathway.

There is a neuroprotective effect of Trpm4 inhibition in mice and rats.

Tet enzymes activate microRNAs required for iPSC derivation.

Long chain polyunsaturated fatty acids supplementation is associated with higher rates of allergic sensitization  at 1 year.

Esrrb associates with BAF and Mbd3/NURD complexes.

Short British students are bullied less than control British students.

T regulatory cells (tTregs) lacking αvβ8 are unable to suppress pathogenic T-cell responses during active inflammation.

In pediatric tissues, the dominant population of T cells are naive T cells emigrants from the thymus.

Inside the body, falciparum parasites form agglomerates of infected cells to avoid spleen clearance.

Mice are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.

Microarray results from culture-amplified mixtures of serotypes correlate well microarray results from uncultured mixtures.

Autophagy deficiency in the liver protects from insulin resistance.

SOD1 integrates oxygen and glucose signals to repress cellular respiration.

MEK inhibitors are not effective in RAS-driven mouse models of cancer.

Adipocytes in major adipose depots descend from cells with a history of Pdgfra expression.

Inhibiting glucose-6-phospate dehydrogenase impairs lipogenesis by reactivating LKB1-AMPK signaling.

APOE4 expression in iPSC-derived neurons results in increased tau phosphorylation.


β1/Ketel is unable to bind microtubules.

Bronchial responsiveness is higher in the summer than in the winter.

Deficiency of Tetraspanin-3 causes improved stem cell-renewal and slows disease propagation.

C. elegans germlines lose their immortal character when nuclear RNAi is disabled.

Roughly one in twenty UK citizens harbor variant Creutzfeldt-Jakob disease prions in lymphoid tissues.

Hematopoietic progenitor cells are never susceptible to HIV-1 infection ex vivo.

Whole brain radiotherapy reduces the occurrence of new brain metastases.

The H3.3K36me3 histone reader protein ZMYND11 has a  higher binding affinity if G34R/V is mutated.

NAC encourages the generation of angiotensin-converting enzyme.

Taking anti-depresents is associated with a increase in the Aβ level in the brain of experimental animals.

The tissue surrounding the granuloma in an immune cell induces an inflammatory immune response.

Proteins synthesized at the growth cone are ubiquitinated at a lower rate than proteins from the cell body.

During the primary early antibody response activated B cells express low levels of EBI2.

During the primary early antibody response activated B cells express high levels of EBI2.

Broadly HIV-1 Neutralizing Antibodies (bnAb) 10EB exhibit a strong affinity for phospholipids.

Normal granulomas formed in the absence of TNF-␣ despite increased bacterial growth.

Piezo1 channels are sensors for cell crowding in epithelial cells.

Coordinated stabilization of kinetochore-microtubule attachments occurs at the prometaphase to metaphase transition.

The binding orientation of the ML-SA1 activator at hTRPML2 is similar to the binding orientation of the ML-SA1 activator at hTRPML1.