Increased expression of Bcl2 is important for the maintenance and progression of tumors.

For every 1,000 children with cerebral palsy, 40-150 of them are premature or underweight at birth.

Autologous transplantation of mesenchymal stem cells has worse graft function than induction therapy with anti-interleukin-2 receptor antibodies.

Taking anti-depresents is associated with a increase in the Aβ level in the brain of experimental animals.

The first MBT repeat of the four malignant brain tumor (4MBT) domain of Drosophila's Sfmbt and of the orthologous mammalian L3MBTL2 is nonessential for the interaction with the spacer region of Drosophila's Pleiohomeotic (Pho) or its human ortholog YY1.

De novo assembly of sequence data has longer contigs than unassembled sequence data.

Having a main partner increases survival rates in HIV patients.

The periosteum consists of 2 layers: the inner layer on the periosteal surface with monocyte/macrophage-lineage cells, osteoblastic cells, and abundant periostin; and the outer layer, consisting of collagens, blood vessels, and nerve endings.

Serotonin receptors play a role in depression

The number of Ndc80 complexes varies with cell cycle timing.

Metastases have genomic aberrations different than those of the primary tumor.

CD44v6 is a marker of constitutive and reprogrammed cancer stem cells driving cancer metastasis.

Expression of MSX2 is induced 3 hours after the addition of BMP4, which occurs later than T and CDX2.

Ninety percent (90%) of kidney cancers in the UK are attributable to excess weight.

C-Met is involved in epithelial-mesenchymal transition in tumor cells.

CHEK2 has a significant role in breast cancer

Phosphorylation of the ATM protein regulates DNA damage-induced neuronal death.

A deficiency of vitamin B6 increases blood levels of homocysteine.

Somatic missense mutations in NT5C2 are not associated with relapse of acute lymphoblastic leukemia.


Induction of urokinase receptor signaling in podocytes has no effect on foot process effacement and proteinuria.

DUSP4 downregulation activates the Ras-ERK pathway

Side effects associated with antidepressants decrease risk of stroke.

Combination nicotine replacement therapies with varenicline or bupropion are not associated with significantly higher long-term abstinence rates at 52 weeks than varenicline monotherapy.

Electrophysiological changes in motor neurons have been observed in patients with amyotrophic lateral sclerosis.

Immune complex triggered cell death leads to extracellular release of oxidized mitochondrial DNA.

Pyridostatin increases telomere fragility in BRCA2-deficient cells.

Patients with panic anxiety show increased CSF levels of hypocretin.

Carriers of the alcohol aldehyde dehydrogenase deficiency mutation drink more that non-carries.

Replacement of OCT4 and SOX2 genes with mesendoderm-related genes has the ability to reprogram human cells.

Decreases in region specific aerobic glycolysis in aged humans causes aging induced changes in brain glucose metabolism.

Decreases in region specific aerobic glycolysis in aged humans slows aging induced changes in brain glucose metabolism.

Osteocytes are not associated with G-CSF induced HSPC mobilization.

Rates of hypertension in patients type 2 diabetes mellitus are similar to those in non-diabetic subjects.

Inhibiting glucose-6-phospate dehydrogenase impairs lipogenesis by reactivating LKB1-AMPK signaling.

SOD1 integrates oxygen and glucose signals to repress cellular respiration.

APOE4 expression in iPSC-derived neurons results in increased tau phosphorylation.

Impaired RhoA activity causes megakaryocytes to exit mitosis without complete karyokinesis


Infection of human T-cell lymphotropic virus type 1 is most frequent in individuals of European origin.

The minor G allele of FOXO3 represses IL-10.

The 7.5% 10-year Atherosclerotic cardiovascular disease risk threshold strategy for initiating statin therapy is less cost-effective than the 10% risk threshold strategy.

Deltex has been shown to interact with eIF3f, a DUB required for Notch activation process.

NAC stabilizes NO to reduce the effect of contrast agents on renal functions.

Unlike transposon mutagenesis, chemical mutagenesis has the capability to induce point mutations that are not typically modeled by insertional mutagenesis approaches.

Oral ibandronate reduces relative risk of new vertebral fractures and clinical vertebral fractures in women.

Tuberculosis-induced granulomas express immune system protein signatures similar to those of the surrounding tissue.

Delayed sleep phase disorder is associated with a dominant coding variation the core circadian clock gene CRY1.

High cardiopulmonary fitness causes decreased mortality rate.

De novo assembly of sequence data has longer contigs than unassembled sequence data.

Approximately 22,500 people are infected with human T-cell lymphotropic virus type 1 in the United Kingdom.

In pediatric tissues, the dominant population of T cells are naive T cells emigrants from the thymus.

T regulatory cells (tTregs) lacking αvβ8 are unable to suppress pathogenic T-cell responses during active inflammation.

Lice attenuated SIV vaccines induce a weaker antigen-specific T cell response in lymph node cells.

Hematopoietic progenitor cells are never susceptible to HIV-1 infection ex vivo.

Mice are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.

IL-10 production by monocytes encourages CD4 + T cell response.

Roughly one in twenty UK citizens harbor variant Creutzfeldt-Jakob disease prions in lymphoid tissues.


Inhibiting HDAC6 decreases survival of mice with ARID1A mutated tumors.

Teaching hospitals provide better care than non-teaching hospitals.

Short British students are bullied more than control British students.

Proteins synthesized at the growth cone are ubiquitinated at a lower rate than proteins from the cell body.

Synaptic activity enhances local synthesis of brain derived neurotrophic factor from postsynaptic dendrites.

Primary cervical cytology screening with HPV detection is no more effective than conventional cytology at detecting severe cervical intraepithelial neoplasia.

The 7.5% 10-year Atherosclerotic cardiovascular disease risk threshold strategy for initiating statin therapy is more cost-effective than the 10% risk threshold strategy.

Ginger is hazardous to mechanically ventilated patients, because these patients are susceptible to mucosal lesions and ulcers.

Occipital activation levels are not correlated with auditory spatial performance in parietal regions of the brain.

SOD1 integrates oxygen and glucose signals to repress cellular respiration.

A deficiency of vitamin B6 increases blood levels of homocysteine.

mTORC2 inhibits xCT antiporter through phosphorylation.

Alirocumab treatment increases apo(a) fractional clearance rate.

Taking anti-depresents is associated with a increase in the Aβ level in the brain of experimental animals.

MEK inhibitors are not effective in RAS-driven mouse models of cancer.

CD44v6 is a marker of constitutive and reprogrammed cancer stem cells driving cancer metastasis.

Impaired RhoA activity causes megakaryocytes to exit mitosis without complete karyokinesis

The minor G allele of FOXO3 represses IL-10.

Deletion of αvβ8 results in a spontaneous inflammatory phenotype.


Inhibiting glucose-6-phospate dehydrogenase impairs lipogenesis by reactivating LKB1-AMPK signaling.

Long chain polyunsaturated fatty acids supplementation is associated with lower rates of allergic sensitization  at 1 year.

Rates of hypertension in patients type 2 diabetes mellitus are similar to those in non-diabetic subjects.

High methylation levels within individual DNA molecules correlates with low nucleosome occupancy across species.

V-9302 causes antitumor responses by increasing cell death and oxidative stress.

Consumption of whole fruits reduces the risk of type 2 diabetes.

Intramembrane cleavage by SPP helps facilitate in the degradation of proteins with a complex membrane orientation.

S-nitrosylated GAPDH physiologically transnitrosylates DNA-activated protein kinase.

There is a neuroprotective effect of Trpm4 inhibition in mice and rats.

Long-term use of statins showed a increased risk of gallstones followed by cholecystectomy.

Diminished ovarian reserve cannot be used in isolation as an indicator of infertility in a non-infertile population.

The phosphorylation of Drp1 at S616 site inhibits its mitochondrial translocation when activated by Ca 2+ /calmodulin-dependent kinase II (CaMKII).

p53 controls autophagy through the AMPK/mTOR-dependent pathway.

The phosphorylation of Drp1 at S616 site promotes its mitochondrial translocation when activated by Ca 2+ /calmodulin-dependent kinase II (CaMKII).

Increased calcium levels activate transgultaminase activity.

Conformational changes of the CD3 complex enable ITAM phosphorylation.

Increased calcium levels repress transgultaminase activity.

DUSP4 downregulation activates the Ras-ERK pathway

Carriers of the alcohol aldehyde dehydrogenase deficiency mutation drink more that non-carries.

Nitric oxide (NO) can S- nitrosylate G protein-coupled receptor kinases (GRKs) to suppress their activity and block phosphorylation.


Inside the body, falciparum parasites form agglomerates of infected cells to avoid spleen clearance.

Oral ibandronate increases relative risk of new vertebral fractures and clinical vertebral fractures in women.

Infection of human T-cell lymphotropic virus type 1 is most frequent in individuals of European origin.

A deficiency of folate decreases blood levels of homocysteine.

AZT given with ribavirin alleviates anemia.

N348I mutations decrease resistance to zidovudine (AZT).

There is no relation between lupus erythematosus and cardiovascular disease

Esrrb associates with BAF and Mbd3/NURD complexes.

Ultrafine Anaphase Bridges represent a mechanism for resolving partially-replicated stretches of DNA.

Sustained transmission of Avian influenza A between humans is not observed.

Cell autonomous sex determination in somatic cells does not occur in Passeriformes.

The tissue surrounding the granuloma in an immune cell induces an inflammatory immune response.

Tuberculosis-induced granulomas express immune system protein signatures similar to those of the surrounding tissue.

Bromodomain proteins promote the differentiation process of bloodstream form (BSF) to procyclic form (PCF) parasites.

The innate immune response is efficient at removing small numbers of parasites.

The center of the granuloma in an immune cell induces an anti-inflammatory immune response.

Mice are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.

Normal granulomas formed in the absence of TNF-␣ despite increased bacterial growth.

Chikungunya virus (CHIKV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in mice.

Polyploidization in megakaryocytes occurs in the presence of an aberrant mitosis.


Intramembrane cleavage by SPP helps facilitate in the degradation of proteins with a complex membrane orientation.

The periosteum consists of 2 layers: the inner layer on the periosteal surface with monocyte/macrophage-lineage cells, osteoblastic cells, and abundant periostin; and the outer layer, consisting of collagens, blood vessels, and nerve endings.

Transplanted human glial cells are incapable of differentiation within the host animal.

Approximately 22,500 people are infected with human T-cell lymphotropic virus type 1 in the United Kingdom.

T cell receptor /CD3 microdomains are unnecessary in the induction of the immunlogical synapse.

Proteins synthesized at the growth cone are ubiquitinated at a lower rate than proteins from the cell body.

Vitamin D deficiency has no effect on the term of child delivery.

High methylation levels within individual DNA molecules correlates with high nucleosome occupancy across species.

Funding the elimination of sporadic malaria cases is a less efficient use of healthcare resources than treating other health priorities in a setting with limited resources.

Long chain polyunsaturated fatty acids supplementation is associated with higher rates of atopic eczema at 1 year.

The binding orientation of the ML-SA1 activator at hTRPML2 is similar to the binding orientation of the ML-SA1 activator at hTRPML1.

Coordinated stabilization of kinetochore-microtubule attachments occurs at the prometaphase to metaphase transition.

An N-formyl group on M3 molecules suppresss strong binding to the second position of the groove.

Cyclin A2 synthesis is necessary to switch from unstable to stable kt-mt attachments in mitosis.

Myelin sheaths play an important role in trophic support.

Polyglutamine binding protein 1 (PQBP1) is the co-receptor of HIV-DNA to trigger cell-autonomous antiviral responses.


KLF4 prevents VSMCs from acquiring genetic characteristics of other cell types within atherosclerotic lesions.

Intramembrane cleavage by SPP helps facilitate in the degradation of proteins with a complex membrane orientation.

Ginger is hazardous to mechanically ventilated patients, because these patients are susceptible to mucosal lesions and ulcers.

p16INK4A accumulation is encoded by CDKN2A.

Thigh-length graduated compression stockings (GCS) reduced deep vein thrombosis in patients admitted to hospital who are immobile because of acute stroke.

Bromodomain proteins promote the differentiation process of bloodstream form (BSF) to procyclic form (PCF) parasites.

Lmna knock-in models are not suitable to test therapeutic approaches against Hutchinson-Gilford progeria syndrome (HGPS).

Near-infrared wavelengths increase penetration depth in fiberoptic confocal microscopy.

The balance between F- and G-actin regulates the orientation of neuronal migration in the developing cerebral cortex.

The innate immune response is efficient at removing small numbers of parasites.

G-CSF prevents MDSCs from infiltrating tumors.

Ly6C hi monocytes have a higher inflammatory capacity compared to their Ly6C lo counterparts.

CD44v6 is a marker of constitutive and reprogrammed cancer stem cells driving cancer metastasis.

T regulatory cells (tTregs) lacking αvβ8 are unable to suppress pathogenic T-cell responses during active inflammation.

There are no known genetic variants associated with radiation therapy-induced second malignancies in pediatric Hodgkin lymphoma patients.

Somatic missense mutations in NT5C2 are not associated with relapse of acute lymphoblastic leukemia.

Primary cervical cytology screening with HPV detection is no more effective than conventional cytology at detecting severe cervical intraepithelial neoplasia.


GEF-H1 activates RhoA in response to extracellular signal-regulated kinase activation.

NR5A2 is important in bile acid homeostasis in humans.

Decreases in region specific aerobic glycolysis in aged humans causes aging induced changes in brain glucose metabolism.

Cell autonomous sex determination in somatic cells does not occur in Passeriformes.

Sweet taste receptors on the tongue are activated by between 300 and 1000 mM glucose.

Genes regulated by Esrrb transcription factor are unaffected by Mbd3 function.

SOD1 integrates oxygen and glucose signals to repress cellular respiration.

Deletion of αvβ8 results in a spontaneous inflammatory phenotype.

Notch signalling can occur between tumor cells and stromal cells.

Differentiated E2f-1, -2, -3 TKO cells in the intestine can exhibit apoptosis.

Deltex has been shown to interact with eIF3f, a DUB required for Notch activation process.

The PDPN gene activates the C-type lectin receptor (CLEC-2).

DUSP4 downregulation activates the Ras-ERK pathway

CENP-B inhibits heterochromatin formation

Esrrb associates with BAF and Mbd3/NURD complexes.


LSD1 plays a role in transcriptional activation

Sweet taste receptors on the tongue are activated by between 300 and 1000 mM glucose.

Immune complex triggered cell death leads to extracellular release of oxidized mitochondrial DNA.

The actual sequences of CP-1 and CR-5 regions are evolutionarily conserved throughout most eukaryotes.

BRCA 1 mutation carriers' risk of breast and ovarian cancer  is not influence by the location of the mutation.

C. elegans germlines lose their immortal character when nuclear RNAi is disabled.

Genomic instability in leukemia cells results from a decrease in reactive oxygen species from oncogene activation.

Monoclonal antibody targeting of N-cadherin promotes growth.

Lupus-prone mice infected with curliproducing bacteria have lower autoantibody titers compared to controls.

Serotonin receptors play a role in depression

Serotonin receptors have no effect on depression

NLRP12 is a positive regulator of T-cell receptor activation.

Conformational changes of the CD3 complex enable ITAM phosphorylation.

Phosphorylation of the ATM protein regulates DNA damage-induced neuronal death.

The binding orientation of the ML-SA1 activator at hTRPML2 is similar to the binding orientation of the ML-SA1 activator at hTRPML1.

p53 controls autophagy through the AMPK/mTOR-dependent pathway.


Lice attenuated SIV vaccines induce a weaker antigen-specific T cell response in lymph node cells.

Valproic acid (VPA) treatment allows reprogramming by the microRNA cluster miR302/367.

V-9302 causes antitumor responses by increasing cell death and oxidative stress.

During the primary early antibody response activated B cells express low levels of EBI2.

Intramembrane cleavage by SPP helps facilitate in the degradation of proteins with a complex membrane orientation.

High cardiopulmonary fitness causes decreased mortality rate.

Pseudoknots alter gene expression by inducing ribosomal frameshifts in viruses.

Genetic deficiency of mast cells leads to increased weight gain in a mouse model of diet-induced obesity.

Broadly HIV-1 Neutralizing Antibodies (bnAb) 10EB exhibit a strong affinity for phospholipids.

Hematopoietic progenitor cells are never susceptible to HIV-1 infection ex vivo.

T regulatory cells (tTregs) lacking αvβ8 are unable to suppress pathogenic T-cell responses during active inflammation.

In pediatric tissues, the dominant population of T cells are naive T cells emigrants from the thymus.

Approximately 22,500 people are infected with human T-cell lymphotropic virus type 1 in the United Kingdom.

IL-10 production by monocytes encourages CD4 + T cell response.

Infection of human T-cell lymphotropic virus type 1 is most frequent in individuals of European origin.

Golli-deficient T-cells are hyper proliferative in initial clonal expansion.

Golli-deficient T-cells are dormant in initial clonal expansion.

Mice are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.

T cell receptor /CD3 microdomains are unnecessary in the induction of the immunlogical synapse.


Lithium damages function in the SCA1 mouse model

Golli-deficient T-cells are dormant in initial clonal expansion.

Asymptomatic bacteriuria increases risk for preterm delivery and low birth weight.

The 7.5% 10-year Atherosclerotic cardiovascular disease risk threshold strategy for initiating statin therapy is less cost-effective than the 10% risk threshold strategy.

Ly6C hi monocytes have a higher inflammatory capacity compared to their Ly6C lo counterparts.

MEK inhibitors are not effective in RAS-driven mouse models of cancer.

The center of the granuloma in an immune cell induces an anti-inflammatory immune response.

Thigh-length graduated compression stockings (GCS) reduced deep vein thrombosis in patients admitted to hospital who are immobile because of acute stroke.

Golli-deficient T-cells are hyper proliferative in initial clonal expansion.

Genomic instability in leukemia cells results from an increase in reactive oxygen species from oncogene activation.

p16INK4A accumulation is encoded by CDKN2A.

Genomic instability in leukemia cells results from a decrease in reactive oxygen species from oncogene activation.

Deletion of αvβ8 results in a spontaneous inflammatory phenotype.

Impaired RhoA activity causes megakaryocytes to exit mitosis without complete karyokinesis

A deficiency of vitamin B6 increases blood levels of homocysteine.

Valproic acid (VPA) treatment allows reprogramming by the microRNA cluster miR302/367.

During the primary early antibody response activated B cells express low levels of EBI2.

MUC1-C inhibits the NF-κB p65 signaling pathway by interacting with IκB kinase ß.


Lmna knock-in models are not suitable to test therapeutic approaches against Hutchinson-Gilford progeria syndrome (HGPS).

Impaired RhoA activity causes megakaryocytes to exit mitosis without complete karyokinesis

p53 controls autophagy through the AMPK/mTOR-dependent pathway.

Incidence rates of cervical cancer have increased over time.

Somatic missense mutations in NT5C2 are not associated with relapse of acute lymphoblastic leukemia.

Polyploidization in megakaryocytes occurs in the presence of an aberrant mitosis.

Lice attenuated SIV vaccines induce a weaker antigen-specific T cell response in lymph node cells.

IFI16 promotes STING phosphorylation and translocation, resulting in elevated activation of STING induced by cGAMP.

Delayed sleep phase disorder is associated with a dominant coding variation the core circadian clock gene CRY1.

There is no relation between lupus erythematosus and cardiovascular disease

Colloid exposure has no effect on morbidity.

Unlike transposon mutagenesis, chemical mutagenesis has the capability to induce point mutations that are not typically modeled by insertional mutagenesis approaches.

The 7.5% 10-year Atherosclerotic cardiovascular disease risk threshold strategy for initiating statin therapy is less cost-effective than the 10% risk threshold strategy.

The 7.5% 10-year Atherosclerotic cardiovascular disease risk threshold strategy for initiating statin therapy is more cost-effective than the 10% risk threshold strategy.

Autologous transplantation of mesenchymal stem cells has higher rates of rejection than induction therapy with anti-interleukin-2 receptor antibodies.

25% of patients with melanoma and an objective response to PD-1 blockade will experience a progression in their melanoma.

N348I mutations decrease resistance to zidovudine (AZT).

There are no known genetic variants associated with radiation therapy-induced second malignancies in pediatric Hodgkin lymphoma patients.

Rates of hypertension in patients type 2 diabetes mellitus are similar to those in non-diabetic subjects.

Whole brain radiotherapy reduces the occurrence of new brain metastases.


Localization of PIN1 in the Arabidopsis embryo requires VPS9a

Hematopoietic progenitor cells are never susceptible to HIV-1 infection ex vivo.

Low saturated fat diets do not have adverse effects on growth or development of infants.

Inside the body, falciparum parasites form agglomerates of infected cells to avoid spleen clearance.

Low saturated fat diets have adverse effects on growth or development of infants.

G-CSF prevents MDSCs from infiltrating tumors.

A deficiency of folate decreases blood levels of homocysteine.

A deficiency of vitamin B6 increases blood levels of homocysteine.

Inhibiting HDAC6 decreases survival of mice with ARID1A mutated tumors.

Somatic missense mutations in NT5C2 are associated with relapse of acute lymphoblastic leukemia.

Some signals for alternative polyadenylation sites are encoded in transposable elements.

The phosphorylation of Drp1 at S616 site inhibits its mitochondrial translocation when activated by Ca 2+ /calmodulin-dependent kinase II (CaMKII).

LSD1 plays a role in transcriptional activation

The binding orientation of the ML-SA1 activator at hTRPML2 is similar to the binding orientation of the ML-SA1 activator at hTRPML1.

Polyglutamine binding protein 1 (PQBP1) is the co-receptor of HIV-DNA to trigger cell-autonomous antiviral responses.

C-Met is involved in epithelial-mesenchymal transition in tumor cells.

Presence of stemloops is important for reverse transcription in short interspersed nuclear elements (SINEs).


Long chain polyunsaturated fatty acids supplementation is associated with higher rates of allergic sensitization  at 1 year.

The tissue surrounding the granuloma in an immune cell induces an inflammatory immune response.

IL-10 production by monocytes encourages CD4 + T cell response.

The H3.3K36me3 histone reader protein ZMYND11 has a  higher binding affinity if G34R/V is mutated.

Ginger is safe for mechanically ventilated patients.

Autologous transplantation of mesenchymal stem cells has worse graft function than induction therapy with anti-interleukin-2 receptor antibodies.

Hypoglycemia decreases the risk of dementia.

Falsified artemisinin family drugs with no active ingredient are generally safe.

Ultrafine Anaphase Bridges represent a mechanism for resolving partially-replicated stretches of DNA.

Some signals for alternative polyadenylation sites are encoded in transposable elements.

Long chain polyunsaturated fatty acids supplementation is associated with lower rates of allergic sensitization  at 1 year.

Long chain polyunsaturated fatty acids supplementation is associated with higher rates of atopic eczema at 1 year.

Low saturated fat diets have adverse effects on growth or development of infants.

High levels of copeptin increase risk of diabetes.

Low saturated fat diets do not have adverse effects on growth or development of infants.

Combination nicotine replacement therapies with varenicline or bupropion are not associated with significantly higher long-term abstinence rates at 52 weeks than varenicline monotherapy.

Autophagy deficiency in the liver protects from insulin resistance.

AZT given with ribavirin alleviates anemia.


Long chain polyunsaturated fatty acids supplementation is associated with higher rates of atopic eczema at 1 year.

Hypertension can be accurately diagnosed with ambulatory blood pressure monitoring.

There are four spatial channels in each hemifield of the auditory cortex of cats.

Pattern recognition receptors are transcripts determinant for resistance to Plasmodium infection.

G-CSF prevents MDSCs from infiltrating tumors.

Propriospinal interneurons that play a role in the plastic reorganization of spinal circuits are not required for recovery from spinal cord injury.

Chikungunya virus (CHIKV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in mice.

Adult tissue-resident macrophages possess a self-renewing capacity.

APOE4 expression in iPSC-derived neurons results in increased tau phosphorylation.

Decreases in region specific aerobic glycolysis in aged humans causes aging induced changes in brain glucose metabolism.

N348I mutations decrease resistance to zidovudine (AZT).

Bariatric surgery reduces resolution of diabetes.

PEP carboxylase enhances threonine production in E. coli.

Consumption of whole fruits reduces the risk of type 2 diabetes.


Long chain polyunsaturated fatty acids supplementation is associated with lower rates of allergic sensitization  at 1 year.

Serotonin receptors have no effect on depression

25% of patients with melanoma and an objective response to PD-1 blockade will experience a progression in their melanoma.

Rapamycin treatment raises G-CSF levels.

MUC1-C inhibits the NF-κB p65 signaling pathway by interacting with IκB kinase ß.

T regulatory cells (tTregs) lacking αvβ8 are unable to suppress pathogenic T-cell responses during active inflammation.

Having a main partner increases survival rates in HIV patients.

The proportion of people with visual difficulty is two times higher in high-income countries than in low-income countries.

Physical injury activates transgultaminase activity.

Antibiotic induced alterations in the gut microbiome increase resistance against Clostridium difficile

Rates of hypertension in patients type 2 diabetes mellitus are similar to those in non-diabetic subjects.


Long-term use of statins showed a decreased risk of gallstones followed by cholecystectomy.

Long chain polyunsaturated fatty acids supplementation is associated with higher rates of allergic sensitization  at 1 year.

Supracellular actomyosin structures are found at boundaries in Drosophila wing imaginal discs.

Occipital activation levels are not correlated with auditory spatial performance in parietal regions of the brain.

The DESMOND program achieved a significant impact on lifestyles outcomes.

10-20% of people with severe mental disorder receive no treatment in low and middle income countries.

Thigh-length graduated compression stockings (GCS) reduced deep vein thrombosis in patients admitted to hospital who are immobile because of acute stroke.

Presence of stemloops is important for reverse transcription in short interspersed nuclear elements (SINEs).

CD44v6 is a marker of constitutive and reprogrammed cancer stem cells driving cancer metastasis.

Vitamin D deficiency has no effect on the term of child delivery.

KLF4 prevents VSMCs from acquiring genetic characteristics of other cell types within atherosclerotic lesions.

Long-term use of statins showed a increased risk of gallstones followed by cholecystectomy.

A breast cancer patient's capacity to metabolize tamoxifen has no effect on treatment outcome.

25% of patients with melanoma and an objective response to PD-1 blockade will experience a progression in their melanoma.

The 7.5% 10-year Atherosclerotic cardiovascular disease risk threshold strategy for initiating statin therapy is less cost-effective than the 10% risk threshold strategy.

No strong relationship has been found with Pioglitazone use and increased risk for pancreatic cancer

Side effects associated with antidepressants increases risk of mortality in postmenopausal women.

The 7.5% 10-year Atherosclerotic cardiovascular disease risk threshold strategy for initiating statin therapy is more cost-effective than the 10% risk threshold strategy.

Pretreatment with the Arp2/3 inhibitor CK-666 is not associated with lamelliopodia formation.

Higher initial mortality is associated with antidepressant use.


Long-term use of statins showed a increased risk of gallstones followed by cholecystectomy.

All six cathelicidins are located on chromosome two.

β1/Ketel is unable to bind microtubules.

Transcription factor EB prevents transcription of pro-inflammatory cytokines in macrophages infected with Staphylococcus aureus.

All phenotypes associated with reduced IIS require the gene daf-16.

SOD1 integrates oxygen and glucose signals to repress cellular respiration.

Delayed sleep phase disorder is associated with a dominant coding variation the core circadian clock gene CRY1.

Ninety percent (90%) of kidney cancers in the UK are attributable to excess weight.

Teaching hospitals provide better care than non-teaching hospitals.

Side effects associated with antidepressants increases risk of myocardial infarction.


Low saturated fat diets do not have adverse effects on growth or development of infants.

Delayed sleep phase disorder is associated with a dominant coding variation the core circadian clock gene CRY1.

Patients with panic anxiety show increased CSF levels of hypocretin.

Pyridostatin delays checkpoint activation.

Funding the elimination of sporadic malaria cases is a less efficient use of healthcare resources than treating other health priorities in a setting with limited resources.

Osteocytes are not associated with G-CSF induced HSPC mobilization.

Somatic missense mutations in NT5C2 are not associated with relapse of acute lymphoblastic leukemia.

Consumption of whole fruits reduces the risk of type 2 diabetes.

Chronic aerobic exercise alters endothelial function, impairing vasodilating mechanisms mediated by NO.

The H3.3K36me3 histone reader protein ZMYND11 has a  higher binding affinity if G34R/V is mutated.

Golli-deficient T-cells are dormant in initial clonal expansion.

Low saturated fat diets have adverse effects on growth or development of infants.

Obesity is determined in part by genetic factors.

Asymptomatic bacteriuria has no effect on the risk for preterm delivery and low birth weight.

High levels of copeptin increase risk of diabetes.

Asymptomatic bacteriuria increases risk for preterm delivery and low birth weight.

Long chain polyunsaturated fatty acids supplementation is associated with higher rates of atopic eczema at 1 year.

Vitamin D deficiency has no effect on the term of child delivery.


Low saturated fat diets have adverse effects on growth or development of infants.

Ginger is safe for mechanically ventilated patients.

Oral ibandronate reduces relative risk of new vertebral fractures and clinical vertebral fractures in women.

Lithium damages function in the SCA1 mouse model

Inhibiting glucose-6-phospate dehydrogenase impairs lipogenesis by reactivating LKB1-AMPK signaling.

Transient IFN-γ exposure leads to long-lived infammatory responses in cancer cells due to IFN-γ retention on the cell surface.

GEF-H1 activates RhoA in response to extracellular signal-regulated kinase activation.

Pretreatment with the Arp2/3 inhibitor CK-666 is not associated with lamelliopodia formation.

The phosphorylation of Drp1 at S616 site inhibits its mitochondrial translocation when activated by Ca 2+ /calmodulin-dependent kinase II (CaMKII).

Bariatric surgery has a deleterious impact on mental health.

Mitochondria are uninvolved in processes related to cell signaling.

Long chain polyunsaturated fatty acids supplementation is associated with lower rates of allergic sensitization  at 1 year.


Lupus-prone mice infected with curliproducing bacteria have lower autoantibody titers compared to controls.

A deficiency of vitamin B6 increases blood levels of homocysteine.

Verbal autopsy (VA) performed well in distinguishing between different injury categories in the elderly population.

Hematopoietic progenitor cells are never susceptible to HIV-1 infection ex vivo.

NLRP12 is a positive regulator of T-cell receptor activation.

A country's Vaccine Alliance (GAVI) eligibility is associated with accelerated adoption of the Hub vaccine.

Participants who quit smoking reduce lung cancer risk by approximately 5%.

Occipital activation levels are not correlated with auditory spatial performance in parietal regions of the brain.

BRCA 1 mutation carriers' risk of breast and ovarian cancer  is not influence by the location of the mutation.

Delayed sleep phase disorder is associated with a dominant coding variation the core circadian clock gene CRY1.

The risk of cancer is lower in individuals with a history of heavy alcohol consumption.

Mice are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.

Chikungunya virus (CHIKV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in mice.

Rates of hypertension in patients type 2 diabetes mellitus are similar to those in non-diabetic subjects.

Normal granulomas formed in the absence of TNF-␣ despite increased bacterial growth.

Deletion of αvβ8 results in a spontaneous inflammatory phenotype.

Tuberculosis-induced granulomas express immune system protein signatures similar to those of the surrounding tissue.

There is no relation between lupus erythematosus and cardiovascular disease

Athletes with or without a concussion have smaller volumes of hippocampal gray matter compared to healthy controls.

In rhesus macaques, daily subcutaneous injections of emtricitabine protect against rectally transmitted simian-human immunodeficiency virus.


Ly6C hi monocytes have a higher inflammatory capacity compared to their Ly6C lo counterparts.

IFI16 promotes STING phosphorylation and translocation, resulting in elevated activation of STING induced by cGAMP.

Lice attenuated SIV vaccines induce a weaker antigen-specific T cell response in lymph node cells.

Rates of hypertension in patients type 2 diabetes mellitus are similar to those in non-diabetic subjects.

Oral ibandronate reduces relative risk of new vertebral fractures and clinical vertebral fractures in women.

Pretreatment with the Arp2/3 inhibitor CK-666 is not associated with lamelliopodia formation.

Persister cells lead to clinical relapse in cancer patients.

The first MBT repeat of the four malignant brain tumor (4MBT) domain of Drosophila's Sfmbt and of the orthologous mammalian L3MBTL2 is nonessential for the interaction with the spacer region of Drosophila's Pleiohomeotic (Pho) or its human ortholog YY1.

Pyridostatin delays checkpoint activation.

Electrophysiological changes in motor neurons have been observed in patients with amyotrophic lateral sclerosis.

KLF4 prevents VSMCs from acquiring genetic characteristics of other cell types within atherosclerotic lesions.

IL-10 production by monocytes encourages CD4 + T cell response.

CD44v6 is a marker of constitutive and reprogrammed cancer stem cells driving cancer metastasis.

The C-type lectin receptor (CLEC-2) rearranges the actin cytoskeleton in dendritic cells to suppress motility along stromal surfaces.

Adult tissue-resident macrophages are maintained independent of circulating monocytes.

F4/80+ macrophages are located in the periosteum.

Adult tissue-resident macrophages possess a self-renewing capacity.

p53 controls autophagy through the AMPK/mTOR-dependent pathway.


Lysine histone demethylase inhibitor JIB 04 is primarily active against KDM5A.

MUC1-C inhibits the NF-κB p65 signaling pathway by interacting with IκB kinase ß.

The PDPN gene activates the C-type lectin receptor (CLEC-2).

Conformational changes of the CD3 complex enable ITAM phosphorylation.

The 7.5% 10-year Atherosclerotic cardiovascular disease risk threshold strategy for initiating statin therapy is more cost-effective than the 10% risk threshold strategy.

Long chain polyunsaturated fatty acids supplementation is associated with higher rates of atopic eczema at 1 year.

Radiographic verified pneumonia predictions are improved by the combination of physical examinations with C-reactive protein values.

Mitochondria play a major role in calcium homeostasis.

Transient IFN-γ exposure leads to long-lived infammatory responses in cancer cells due to IFN-γ retention on the cell surface.

The H3.3K36me3 histone reader protein ZMYND11 has a  higher binding affinity if G34R/V is mutated.

N348I mutations decrease resistance to zidovudine (AZT).

Inhibiting glucose-6-phospate dehydrogenase impairs lipogenesis by reactivating LKB1-AMPK signaling.

PEP carboxylase suppresses threonine production in E. coli.

The phosphorylation of Drp1 at S616 site inhibits its mitochondrial translocation when activated by Ca 2+ /calmodulin-dependent kinase II (CaMKII).

Combining phosphatidylinositide 3-kinase and MEK 1/2 inhibitors is ineffective at treating KRAS mutant tumors.

p16INK4A accumulation is encoded by CDKN2A.


MEK inhibitors are not effective in RAS-driven mouse models of cancer.

T regulatory cells (tTregs) lacking αvβ8 are unable to suppress pathogenic T-cell responses during active inflammation.

C. elegans germlines lose their immortal character when nuclear RNAi is disabled.

Amitriptyline ineffective as a treatment for chronic tension-type headaches.

Fibroblast growth factor 21 icreases vulnerability to atherosclerosis by modulating adiponectin and SREBP2 levels.

Allele and genotype frequencies of the rs4516035 and rs2298850 SNPs in Mexican populations are associated with region in Mexico.

Diminished ovarian reserve cannot be used in isolation as an indicator of infertility in a non-infertile population.

No strong relationship has been found with Pioglitazone use and increased risk for pancreatic cancer

LSD1 plays a role in transcriptional activation

Participants who quit smoking reduce lung cancer risk by approximately 5%.

CHEK2 has a significant role in breast cancer

CD44v6 is a marker of constitutive and reprogrammed cancer stem cells driving cancer metastasis.

DUSP4 downregulation activates the Ras-ERK pathway

A breast cancer patient's capacity to metabolize tamoxifen has no effect on treatment outcome.

C-Met is involved in epithelial-mesenchymal transition in tumor cells.


MUC1-C inhibits the NF-κB p65 signaling pathway by interacting with IκB kinase ß.

The tissue surrounding the granuloma in an immune cell induces an inflammatory immune response.

Incidence of sepsis has remained stable between 2009-2014.

Genomic instability in leukemia cells results from a decrease in reactive oxygen species from oncogene activation.

Notch signalling can occur between tumor cells and stromal cells.

50% of patients exposed to radiation have activated markers of myofibroblasts.

The appearance of brown-like or beige cells primarily occurs in subcutaneous fat, not visceral fat.

Cell autonomous sex determination in somatic cells does not occur in Passeriformes.

Sweet taste receptors on the tongue are activated by between 300 and 1000 mM glucose.

Conformational changes of the CD3 complex enable ITAM phosphorylation.

Deletion of αvβ8 results in a spontaneous inflammatory phenotype.

NR5A2 is important in bile acid homeostasis in humans.

Transcription factor EB prevents transcription of pro-inflammatory cytokines in macrophages infected with Staphylococcus aureus.

Lysine histone demethylase inhibitor JIB 04 is primarily active against KDM5A.

Deltex has been shown to interact with eIF3f, a DUB required for Notch activation process.

Genes regulated by Esrrb transcription factor are unaffected by Mbd3 function.


Major vault protein (MVP) functions to decrease tumor aggression.

Induction of urokinase receptor signaling in podocytes has no effect on foot process effacement and proteinuria.

Pyridostatin delays checkpoint activation.

The minor G allele of FOXO3 represses IL-10.

Unlike transposon mutagenesis, chemical mutagenesis has the capability to induce point mutations that are not typically modeled by insertional mutagenesis approaches.

Lmna knock-in models are not suitable to test therapeutic approaches against Hutchinson-Gilford progeria syndrome (HGPS).

Chikungunya virus (CHIKV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in mice.

The C-type lectin receptor (CLEC-2) rearranges the actin cytoskeleton in dendritic cells to suppress motility along stromal surfaces.

Genetic deletion of JAM-A decreases gut permeability.

Distant CREs are more conserved among species.

Increased expression of Bcl2 is important for the maintenance and progression of tumors.

Osteocytes are not associated with G-CSF induced HSPC mobilization.

The first MBT repeat of the four malignant brain tumor (4MBT) domain of Drosophila's Sfmbt and of the orthologous mammalian L3MBTL2 is nonessential for the interaction with the spacer region of Drosophila's Pleiohomeotic (Pho) or its human ortholog YY1.

Notch signalling can occur between tumor cells and stromal cells.

G-CSF prevents MDSCs from infiltrating tumors.

Satellite cell dysfunction is not a key factor in sarcopenia development.

Combining phosphatidylinositide 3-kinase and MEK 1/2 inhibitors is ineffective at treating KRAS mutant tumors.

Metastases have genomic aberrations different than those of the primary tumor.


Long-term use of statins showed a decreased risk of gallstones followed by cholecystectomy.

Transcription factor EB prevents transcription of pro-inflammatory cytokines in macrophages infected with Staphylococcus aureus.

The periosteum consists of 2 layers: the inner layer on the periosteal surface with monocyte/macrophage-lineage cells, osteoblastic cells, and abundant periostin; and the outer layer, consisting of collagens, blood vessels, and nerve endings.

Occipital activation levels are not correlated with auditory spatial performance in parietal regions of the brain.

Golli-deficient T-cells are hyper proliferative in initial clonal expansion.

Carriers of the alcohol aldehyde dehydrogenase deficiency mutation drink more that non-carries.

Localization of PIN1 in the Arabidopsis embryo requires VPS9a

Gene expression can be highly variable across genetically identical cells.

PRC1-bound plasmids sediment at a faster rate in unbound plasmids than in sucrose gradients.

Near-infrared wavelengths decrease penetration depth in fiberoptic confocal microscopy.

Some countries have achieved the goal of eradicting malaria.

Funding the elimination of sporadic malaria cases is a less efficient use of healthcare resources than treating other health priorities in a setting with limited resources.

Mice are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.

The innate immune response is efficient at removing small numbers of parasites.

Sustained transmission of Avian influenza A between humans is not observed.

Chikungunya virus (CHIKV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in mice.

Tuberculosis incidence is correlated with residential crowding in the UK.

10-20% of people with severe mental disorder receive no treatment in low and middle income countries.

Suboptimal nutrition is a leading cause of chronic disease


Medicare beneficiaries experienced a median delay of 2.4 days between lung cancer diagnosis and initiation of chemotherapy in 2006.

Transplanted human glial progenitor cells can form a neural network with host animals' neurons.

Oral ibandronate reduces relative risk of new vertebral fractures and clinical vertebral fractures in women.

Rates of hypertension in patients type 2 diabetes mellitus are similar to those in non-diabetic subjects.

Vaccinating the gastrointestinal tract is not effective in protecting rectal and vaginal mucosa.

Electromagnetic interference has no effect on Radio Frequency Identification (RFID) readability and reading distances.

Aspirin encourages the production of PGE2.

Long chain polyunsaturated fatty acids supplementation is associated with lower rates of allergic sensitization  at 1 year.

Polyglutamine binding protein 1 (PQBP1) is the co-receptor of HIV-DNA to trigger cell-autonomous antiviral responses.

Short British students are bullied more than control British students.

Participants who quit smoking reduce lung cancer risk by approximately 5%.

No strong relationship has been found with Pioglitazone use and increased risk for pancreatic cancer

A breast cancer patient's capacity to metabolize tamoxifen has no effect on treatment outcome.

Ninety percent (90%) of kidney cancers in the UK are attributable to excess weight.

Incidence rates of cervical cancer have increased over time.

The risk of cancer is lower in individuals with a history of heavy alcohol consumption.

Thoracic aortic aneurysms affect 70-100 individuals per 100,000 people per year.

There are no known genetic variants associated with radiation therapy-induced second malignancies in pediatric Hodgkin lymphoma patients.

The 7.5% 10-year Atherosclerotic cardiovascular disease risk threshold strategy for initiating statin therapy is less cost-effective than the 10% risk threshold strategy.


Metastases have genomic aberrations different than those of the primary tumor.

Chikungunya virus (CHIKV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in mice.

Propriospinal interneurons that play a role in the plastic reorganization of spinal circuits are not required for recovery from spinal cord injury.

The proportion of people with visual difficulty is two times higher in high-income countries than in low-income countries.

Taking anti-depresents is associated with a increase in the Aβ level in the brain of experimental animals.

Cellular aging is uncorrelated with an older appearance.

Adult tissue-resident macrophages possess a self-renewing capacity.

The 7.5% 10-year Atherosclerotic cardiovascular disease risk threshold strategy for initiating statin therapy is more cost-effective than the 10% risk threshold strategy.

Colloid exposure has no effect on morbidity.

Satellite cell dysfunction is not a key factor in sarcopenia development.

Hematopoietic progenitor cells are never susceptible to HIV-1 infection ex vivo.

50% of patients exposed to radiation have activated markers of myofibroblasts.

MEK inhibitors are not effective in RAS-driven mouse models of cancer.

Increased expression of Bcl2 is important for the maintenance and progression of tumors.

Polyploidization in megakaryocytes occurs in the presence of an aberrant mitosis.

CD44v6 is a marker of constitutive and reprogrammed cancer stem cells driving cancer metastasis.

Hypoglycemia decreases the risk of dementia.


Mice are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.

mTORC2 inhibits xCT antiporter through phosphorylation.

The phosphorylation of Drp1 at S616 site promotes its mitochondrial translocation when activated by Ca 2+ /calmodulin-dependent kinase II (CaMKII).

Decreases in region specific aerobic glycolysis in aged humans causes aging induced changes in brain glucose metabolism.

Healthy volunteers exhibit rapid and transient decrease of cellular ATP after being bolus-injected with fructose.

Nitric oxide (NO) can S- nitrosylate G protein-coupled receptor kinases (GRKs) to suppress their activity and block phosphorylation.

In the UK, drowning affects boys at a higher rate than girls.

Correlative electron microscopy and superresolution fluorescence imaging are imaging techniques.

N348I mutations decrease resistance to zidovudine (AZT).

Chikungunya virus (CHIKV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in mice.

Tuberculosis-induced granulomas express immune system protein signatures similar to those of the surrounding tissue.

The innate immune response is efficient at removing small numbers of parasites.

Sustained transmission of Avian influenza A between humans is not observed.

Approximately 22,500 people are infected with human T-cell lymphotropic virus type 1 in the United Kingdom.

Lupus-prone mice infected with curliproducing bacteria have lower autoantibody titers compared to controls.

Some countries have achieved the goal of eradicting malaria.

Infection of human T-cell lymphotropic virus type 1 is most frequent in individuals of European origin.


Microarray results from culture-amplified mixtures of serotypes correlate well microarray results from uncultured mixtures.

Genes regulated by Esrrb transcription factor are unaffected by Mbd3 function.

Roughly one in two thousand UK citizens harbor variant Creutzfeldt-Jakob disease prions in lymphoid tissues.

Myelin sheaths play an important role in trophic support.

Pyridostatin delays checkpoint activation.

Inhibiting glucose-6-phospate dehydrogenase impairs lipogenesis by reactivating LKB1-AMPK signaling.

Localization of PIN1 in the Arabidopsis embryo requires VPS9a

The binding orientation of the ML-SA1 activator at hTRPML2 is similar to the binding orientation of the ML-SA1 activator at hTRPML1.

Metastases have genomic aberrations different than those of the primary tumor.

Incidence rates of cervical cancer have increased over time.

High methylation levels within individual DNA molecules correlates with high nucleosome occupancy across species.

De novo assembly of sequence data has longer contigs than unassembled sequence data.

Genome size differences in rice are explained by LTR retrotransposon expansion.

Gene expression can be highly variable across genetically identical cells.

High methylation levels within individual DNA molecules correlates with low nucleosome occupancy across species.

Pattern recognition receptors are transcripts determinant for resistance to Plasmodium infection.

Unlike transposon mutagenesis, chemical mutagenesis has the capability to induce point mutations that are not typically modeled by insertional mutagenesis approaches.

Correlative electron microscopy and superresolution fluorescence imaging are imaging techniques.


Mitochondria are uninvolved in processes related to cell signaling.

p53 controls autophagy through the AMPK/mTOR-dependent pathway.

Motor neurons from patients with amyotrophic lateral sclerosis have electrophysiological changes relative to healthy patients.

There are no known genetic variants associated with radiation therapy-induced second malignancies in pediatric Hodgkin lymphoma patients.

The center of the granuloma in an immune cell induces an anti-inflammatory immune response.

Long-term use of statins showed a increased risk of gallstones followed by cholecystectomy.

Monoclonal antibody targeting of N-cadherin promotes growth.

The balance between F- and G-actin regulates the orientation of neuronal migration in the developing cerebral cortex.

Side effects associated with antidepressants decrease risk of stroke.

Rapamycin treatment raises G-CSF levels.

The PDPN gene activates the C-type lectin receptor (CLEC-2).

Mitochondria play a major role in calcium homeostasis.

Polyploidization in megakaryocytes occurs in the presence of an aberrant mitosis.

Impaired RhoA activity causes megakaryocytes to exit mitosis without complete karyokinesis

The ring complexes of chromosomes in C. elegans oocytes are built in discrete layers.

Cyclin A2 synthesis is necessary to switch from unstable to stable kt-mt attachments in mitosis.

Proteins synthesized at the growth cone are ubiquitinated at a lower rate than proteins from the cell body.

Immune complex triggered cell death leads to extracellular release of oxidized mitochondrial DNA.

Adult tissue-resident macrophages possess a self-renewing capacity.

Coordinated stabilization of kinetochore-microtubule attachments occurs at the prometaphase to metaphase transition.


Mitochondria play a major role in calcium homeostasis.

Normal granulomas formed in the absence of TNF-␣ despite increased bacterial growth.

T regulatory cells (tTregs) lacking αvβ8 are unable to suppress pathogenic T-cell responses during active inflammation.

Synaptic activity impairs local synthesis of brain derived neurotrophic factor from postsynaptic dendrites.

β1/Ketel is unable to bind microtubules.

Bariatric surgery has a deleterious impact on mental health.

Mice are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.

Deltex has been shown to interact with eIF3f, a DUB required for Notch activation process.

Decreases in region specific aerobic glycolysis in aged humans slows aging induced changes in brain glucose metabolism.

Tet enzymes activate microRNAs required for iPSC derivation.

Myelin sheaths play an important role in trophic support.

p53 controls autophagy through the AMPK/mTOR-dependent pathway.

Cytosolic proteins fail to bind to iron-responsive elements on mRNAs coding for TFRC1.

Increased calcium levels activate transgultaminase activity.


Monoclonal antibody targeting of N-cadherin promotes growth.

Deltex has been shown to interact with eIF3f, a DUB required for Notch activation process.

Falsified artemisinin family drugs with no active ingredient can be life-threatening.

High methylation levels within individual DNA molecules correlates with low nucleosome occupancy across species.

Deficiency of Tetraspanin-3 causes impaired stem cell-renewal and disease propagation.

T cell receptor /CD3 microdomains are unnecessary in the induction of the immunlogical synapse.

NAC stabilizes NO to reduce the effect of contrast agents on renal functions.

The innate immune response is efficient at removing small numbers of parasites.

Somatic missense mutations in NT5C2 are not associated with relapse of acute lymphoblastic leukemia.

Low saturated fat diets have adverse effects on growth or development of infants.

N348I mutations decrease resistance to zidovudine (AZT).

A breast cancer patient's capacity to metabolize tamoxifen has no effect on treatment outcome.

During the primary early antibody response activated B cells express high levels of EBI2.

During the primary early antibody response activated B cells express low levels of EBI2.

G-CSF prevents MDSCs from infiltrating tumors.

Rapamycin treatment raises G-CSF levels.

Side effects associated with antidepressants decrease risk of stroke.

AZT given with ribavirin alleviates anemia.

V-9302 causes antitumor responses by increasing cell death and oxidative stress.


Motor neurons from patients with amyotrophic lateral sclerosis have electrophysiological changes relative to healthy patients.

Colloid exposure has no effect on morbidity.

There is a neuroprotective effect of Trpm4 inhibition in mice and rats.

The proportion of people with visual difficulty is two times higher in high-income countries than in low-income countries.

Sweet taste receptors on the tongue are activated by between 300 and 1000 mM glucose.

The binding orientation of the ML-SA1 activator at hTRPML2 is similar to the binding orientation of the ML-SA1 activator at hTRPML1.

Piezo1 channels are sensors for cell crowding in epithelial cells.

Bromodomain proteins promote the differentiation process of bloodstream form (BSF) to procyclic form (PCF) parasites.

High levels of copeptin increase risk of diabetes.

Long chain polyunsaturated fatty acids supplementation is associated with higher rates of allergic sensitization  at 1 year.

Genes regulated by Esrrb transcription factor are unaffected by Mbd3 function.

Electrophysiological changes in motor neurons have been observed in patients with amyotrophic lateral sclerosis.

Propriospinal interneurons that play a role in the plastic reorganization of spinal circuits are not required for recovery from spinal cord injury.

The balance between F- and G-actin regulates the orientation of neuronal migration in the developing cerebral cortex.

Athletes with or without a concussion have smaller volumes of hippocampal gray matter compared to healthy controls.

p53 controls autophagy through the AMPK/mTOR-dependent pathway.

Adipocytes in major adipose depots descend from cells with a history of Pdgfra expression.

There are four spatial channels in each hemifield of the auditory cortex of cats.

Transplanted human glial progenitor cells can form a neural network with host animals' neurons.

Synaptic activity impairs local release of brain derived neurotrophic factor from postsynaptic dendrites.


Myelin sheaths play an important role in trophic support.

The number of unfertilized oocytes in mated hermaphrodites decreases with age.

The ring complexes of chromosomes in C. elegans oocytes are built in discrete layers.

Lmna knock-in models are not suitable to test therapeutic approaches against Hutchinson-Gilford progeria syndrome (HGPS).

Normal granulomas formed in the absence of TNF-␣ despite increased bacterial growth.

Bariatric surgery has a deleterious impact on mental health.

Diminished ovarian reserve cannot be used in isolation as an indicator of infertility in a non-infertile population.

Inhibiting HDAC6 decreases survival of mice with ARID1A mutated tumors.

Glucose restriction to 0.05% increases RLS (replicative life span) by 20-40% in S. cerevisiae.

Healthy volunteers exhibit rapid and transient decrease of cellular ATP after being bolus-injected with fructose.

Mitochondria play a major role in calcium homeostasis.

Adult tissue-resident macrophages possess a self-renewing capacity.

Coordinated stabilization of kinetochore-microtubule attachments occurs at the prometaphase to metaphase transition.

The C-type lectin receptor (CLEC-2) rearranges the actin cytoskeleton in dendritic cells to suppress motility along stromal surfaces.

Supracellular actomyosin structures are found at boundaries in Drosophila wing imaginal discs.

Proteins synthesized at the growth cone are ubiquitinated at a lower rate than proteins from the cell body.

Adult tissue-resident macrophages are maintained independent of circulating monocytes.

Mitochondria are uninvolved in processes related to cell signaling.

Intramembrane cleavage by SPP helps facilitate in the degradation of proteins with a complex membrane orientation.


N348I mutations decrease resistance to zidovudine (AZT).

PEP carboxylase suppresses threonine production in E. coli.

Differentiated E2f-1, -2, -3 TKO cells in the intestine can exhibit apoptosis.

Inside the body, falciparum parasites form agglomerates of infected cells to avoid spleen clearance.

The PDPN gene activates the C-type lectin receptor (CLEC-2).

C-Met is involved in epithelial-mesenchymal transition in tumor cells.

c-MYC is important for maintaining pluripotent state of pluripotent stem cells.

Phosphorylation of the ATM protein regulates DNA damage-induced neuronal death.

8% of burn patients are admitted for hospitalization and further treatment after appearing at hospital emergency wards or outpatient clinics.

Intramembrane cleavage by SPP helps facilitate in the degradation of proteins with a complex membrane orientation.

Deletion of αvβ8 results in a spontaneous inflammatory phenotype.

The number of Ndc80 complexes varies with cell cycle timing.

AZT given with ribavirin alleviates anemia.

Unlike transposon mutagenesis, chemical mutagenesis has the capability to induce point mutations that are not typically modeled by insertional mutagenesis approaches.

A deficiency of folate decreases blood levels of homocysteine.

V-9302 causes antitumor responses by increasing cell death and oxidative stress.

Monoclonal antibody targeting of N-cadherin promotes growth.

An N-formyl group on M3 molecules suppresss strong binding to the second position of the groove.

Somatic missense mutations in NT5C2 are associated with relapse of acute lymphoblastic leukemia.


NAC encourages the generation of angiotensin-converting enzyme.

The risk of cancer is lower in individuals with a history of heavy alcohol consumption.

Cyclin A2 synthesis is necessary to switch from unstable to stable kt-mt attachments in mitosis.

Oral ibandronate reduces relative risk of new vertebral fractures and clinical vertebral fractures in women.

Mice are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.

Decreases in region specific aerobic glycolysis in aged humans slows aging induced changes in brain glucose metabolism.

Low saturated fat diets do not have adverse effects on growth or development of infants.

CD44v6 is a marker of constitutive and reprogrammed cancer stem cells driving cancer metastasis.

Autologous transplantation of mesenchymal stem cells has higher rates of rejection than induction therapy with anti-interleukin-2 receptor antibodies.

The number of unfertilized oocytes in mated hermaphrodites decreases with age.

Self-advocacy training is not effective at decreasing homelessness.

NAC stabilizes NO to reduce the effect of contrast agents on renal functions.

NR5A2 is important in bile acid homeostasis in humans.

Inhibiting glucose-6-phospate dehydrogenase impairs lipogenesis by reactivating LKB1-AMPK signaling.

Nitric oxide (NO) can S- nitrosylate G protein-coupled receptor kinases (GRKs) to suppress their activity and block phosphorylation.

The 7.5% 10-year Atherosclerotic cardiovascular disease risk threshold strategy for initiating statin therapy is more cost-effective than the 10% risk threshold strategy.

Increased calcium levels activate transgultaminase activity.

Increased calcium levels repress transgultaminase activity.

The 7.5% 10-year Atherosclerotic cardiovascular disease risk threshold strategy for initiating statin therapy is less cost-effective than the 10% risk threshold strategy.


NAC stabilizes NO to reduce the effect of contrast agents on renal functions.

The first MBT repeat of the four malignant brain tumor (4MBT) domain of Drosophila's Sfmbt and of the orthologous mammalian L3MBTL2 is nonessential for the interaction with the spacer region of Drosophila's Pleiohomeotic (Pho) or its human ortholog YY1.

Nitric oxide (NO) can S- nitrosylate G protein-coupled receptor kinases (GRKs) to suppress their activity and block phosphorylation.

Genome size differences in rice are explained by LTR retrotransposon expansion.

Thoracic aortic aneurysms affect 70-100 individuals per 100,000 people per year.

Ninety percent (90%) of kidney cancers in the UK are attributable to excess weight.

NR5A2 is important in bile acid homeostasis in humans.

Asymptomatic bacteriuria increases risk for preterm delivery and low birth weight.

Rates of hypertension in patients type 2 diabetes mellitus are similar to those in non-diabetic subjects.

Increased calcium levels repress transgultaminase activity.

Coordinated stabilization of kinetochore-microtubule attachments occurs at the prometaphase to metaphase transition.

Chronic aerobic exercise alters endothelial function, impairing vasodilating mechanisms mediated by NO.

Excess nitric oxide is responsible for vasospasm.

A breast cancer patient's capacity to metabolize tamoxifen has no effect on treatment outcome.

Hypertension can be accurately diagnosed with ambulatory blood pressure monitoring.

Side effects associated with antidepressants increases risk of myocardial infarction.


NLRP12 is a positive regulator of T-cell receptor activation.

The PDPN gene activates the C-type lectin receptor (CLEC-2).

Distant CREs are more conserved among species.

Mice are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.

Golli-deficient T-cells are hyper proliferative in initial clonal expansion.

The 7.5% 10-year Atherosclerotic cardiovascular disease risk threshold strategy for initiating statin therapy is more cost-effective than the 10% risk threshold strategy.

Oral ibandronate increases relative risk of new vertebral fractures and clinical vertebral fractures in women.

Metastases have genomic aberrations different than those of the primary tumor.

PRC1-bound plasmids sediment at a faster rate in unbound plasmids than in sucrose gradients.

Vaccinating the gastrointestinal tract is not effective in protecting rectal and vaginal mucosa.

Ly6C hi monocytes have a higher inflammatory capacity compared to their Ly6C lo counterparts.

IL-10 production by monocytes encourages CD4 + T cell response.

Deltex has been shown to interact with eIF3f, a DUB required for Notch activation process.

T regulatory cells (tTregs) lacking αvβ8 are unable to suppress pathogenic T-cell responses during active inflammation.

LSD1 plays a role in transcriptional activation

T cell receptor /CD3 microdomains are unnecessary in the induction of the immunlogical synapse.

Phosphorylation of the ATM protein regulates DNA damage-induced neuronal death.

Serotonin receptors play a role in depression

mTORC2 inhibits xCT antiporter through phosphorylation.


NR5A2 is important in bile acid homeostasis in humans.

Long chain polyunsaturated fatty acids supplementation is associated with lower rates of allergic sensitization  at 1 year.

Taking anti-depresents is associated with a increase in the Aβ level in the brain of experimental animals.

Gene expression can be highly variable across genetically identical cells.

Bronchial responsiveness is higher in the summer than in the winter.

Lmna knock-in models are not suitable to test therapeutic approaches against Hutchinson-Gilford progeria syndrome (HGPS).

Pseudoknots alter gene expression by inducing ribosomal frameshifts in viruses.

In a naive state, blocking Wingless-Int-1 secretion from mouse embryonic stem cells encourages self-renewal of the mouse embryonic stem cells.

The minor G allele of FOXO3 represses IL-10.

p16INK4A accumulation is encoded by CDKN2A.

Nitric oxide (NO) can S- nitrosylate G protein-coupled receptor kinases (GRKs) to suppress their activity and block phosphorylation.

A deficiency of folate decreases blood levels of homocysteine.

CHEK2 has a significant role in breast cancer

Nrde-3 facilitates heritable silencing in C. elegans by transporting secondary siRNAs to the nucleus.

A deficiency of vitamin B6 increases blood levels of homocysteine.

MUC1-C inhibits the NF-κB p65 signaling pathway by interacting with IκB kinase ß.

Inhibiting glucose-6-phospate dehydrogenase impairs lipogenesis by reactivating LKB1-AMPK signaling.

p53 controls autophagy through the AMPK/mTOR-dependent pathway.


Near-infrared wavelengths decrease penetration depth in fiberoptic confocal microscopy.

The myocardial cell lineage originally develops from cardiac progenitors of mesodermal origin.

Immune complex triggered cell death leads to extracellular release of oxidized mitochondrial DNA.

Piezo1 channels are sensors for cell crowding in epithelial cells.

p16INK4A accumulation is encoded by CDKN2A.

Bariatric surgery has a deleterious impact on mental health.

Normal granulomas formed in the absence of TNF-␣ despite increased bacterial growth.

Falsified artemisinin family drugs with no active ingredient can be life-threatening.

BRCA 1 mutation carriers' risk of breast and ovarian cancer  is not influence by the location of the mutation.

Antibiotic induced alterations in the gut microbiome increase resistance against Clostridium difficile

Monoclonal antibody targeting of N-cadherin promotes growth.

Near-infrared wavelengths increase penetration depth in fiberoptic confocal microscopy.

Correlative electron microscopy and superresolution fluorescence imaging are imaging techniques.

Electromagnetic interference has no effect on Radio Frequency Identification (RFID) readability and reading distances.

Ultrafine Anaphase Bridges represent a mechanism for resolving partially-replicated stretches of DNA.

An N-formyl group on M3 molecules suppresss strong binding to the second position of the groove.

There are four spatial channels in each hemifield of the auditory cortex of cats.

Intramembrane cleavage by SPP helps facilitate in the degradation of proteins with a complex membrane orientation.

Pattern recognition receptors are transcripts determinant for resistance to Plasmodium infection.

The appearance of brown-like or beige cells primarily occurs in subcutaneous fat, not visceral fat.


Near-infrared wavelengths increase penetration depth in fiberoptic confocal microscopy.

Adipocytes in major adipose depots descend from cells with a history of Pdgfra expression.

Deficiency of Tetraspanin-3 causes improved stem cell-renewal and slows disease propagation.

The periosteum consists of 2 layers: the inner layer on the periosteal surface with monocyte/macrophage-lineage cells, osteoblastic cells, and abundant periostin; and the outer layer, consisting of collagens, blood vessels, and nerve endings.

N348I mutations decrease resistance to zidovudine (AZT).

Lice attenuated SIV vaccines induce a weaker antigen-specific T cell response in lymph node cells.

Hematopoietic progenitor cells are never susceptible to HIV-1 infection ex vivo.

Deficiency of Tetraspanin-3 causes impaired stem cell-renewal and disease propagation.

Genetic deficiency of mast cells leads to increased weight gain in a mouse model of diet-induced obesity.

Transcription factor EB prevents transcription of pro-inflammatory cytokines in macrophages infected with Staphylococcus aureus.

Pyridostatin increases telomere fragility in BRCA2-deficient cells.

CRY proteins mediate light signal transduction.


Ninety percent (90%) of kidney cancers in the UK are attributable to excess weight.

Incidence rates of cervical cancer have increased over time.

Broadly HIV-1 Neutralizing Antibodies (bnAb) 10EB exhibit a strong affinity for phospholipids.

C-Met is involved in epithelial-mesenchymal transition in tumor cells.

Inhibiting HDAC6 decreases survival of mice with ARID1A mutated tumors.

Allele and genotype frequencies of the rs4516035 and rs2298850 SNPs in Mexican populations are associated with region in Mexico.

The center of the granuloma in an immune cell induces an anti-inflammatory immune response.

Higher initial mortality is associated with antidepressant use.

β1/Ketel is unable to bind microtubules.

Obesity is determined in part by genetic factors.

Approximately 22,500 people are infected with human T-cell lymphotropic virus type 1 in the United Kingdom.

Genetic deficiency of mast cells leads to increased weight gain in a mouse model of diet-induced obesity.

Thoracic aortic aneurysms affect 70-100 individuals per 100,000 people per year.

The risk of cancer is lower in individuals with a history of heavy alcohol consumption.

Medicare beneficiaries experienced a median delay of 2.4 days between lung cancer diagnosis and initiation of chemotherapy in 2006.

For every 1,000 children with cerebral palsy, 40-150 of them are premature or underweight at birth.

No strong relationship has been found with Pioglitazone use and increased risk for pancreatic cancer


Nitric oxide (NO) can S- nitrosylate G protein-coupled receptor kinases (GRKs) to suppress their activity and block phosphorylation.

PEP carboxylase enhances threonine production in E. coli.

PRC1-bound plasmids sediment at a faster rate in unbound plasmids than in sucrose gradients.

Thigh-length graduated compression stockings (GCS) reduced deep vein thrombosis in patients admitted to hospital who are immobile because of acute stroke.

Distant CREs are more conserved among species.

Electromagnetic interference has no effect on Radio Frequency Identification (RFID) readability and reading distances.

Diminished ovarian reserve cannot be used in isolation as an indicator of infertility in a non-infertile population.

mTORC2 inhibits xCT antiporter through phosphorylation.

Coordinated stabilization of kinetochore-microtubule attachments occurs at the prometaphase to metaphase transition.

Phosphorylation of the ATM protein regulates DNA damage-induced neuronal death.

Electrophysiological changes in motor neurons have been observed in patients with amyotrophic lateral sclerosis.

Excess nitric oxide is responsible for vasospasm.

Serotonin receptors have no effect on depression

Serotonin receptors play a role in depression

NAC stabilizes NO to reduce the effect of contrast agents on renal functions.

Transient IFN-γ exposure leads to long-lived infammatory responses in cancer cells due to IFN-γ retention on the cell surface.

S-nitrosylated GAPDH physiologically transnitrosylates target nuclear proteins.

Chronic aerobic exercise alters endothelial function, impairing vasodilating mechanisms mediated by NO.

NR5A2 is important in bile acid homeostasis in humans.

S-nitrosylated GAPDH physiologically transnitrosylates DNA-activated protein kinase.


No strong relationship has been found with Pioglitazone use and increased risk for pancreatic cancer

Long chain polyunsaturated fatty acids supplementation is associated with lower rates of allergic sensitization  at 1 year.

Vitamin D deficiency has no effect on the term of child delivery.

CENP-B inhibits heterochromatin formation

Cellular aging is uncorrelated with an older appearance.

Transcription factor EB prevents transcription of pro-inflammatory cytokines in macrophages infected with Staphylococcus aureus.

T regulatory cells (tTregs) lacking αvβ8 are unable to suppress pathogenic T-cell responses during active inflammation.

The periosteum consists of 2 layers: the inner layer on the periosteal surface with monocyte/macrophage-lineage cells, osteoblastic cells, and abundant periostin; and the outer layer, consisting of collagens, blood vessels, and nerve endings.

Nrde-3 facilitates heritable silencing in C. elegans by transporting secondary siRNAs to the nucleus.

Vaccinating the gastrointestinal tract is not effective in protecting rectal and vaginal mucosa.

PEP carboxylase enhances threonine production in E. coli.

A breast cancer patient's capacity to metabolize tamoxifen has no effect on treatment outcome.

Side effects associated with antidepressants increases risk of myocardial infarction.

Side effects associated with antidepressants decrease risk of stroke.

Side effects associated with antidepressants increases risk of mortality in postmenopausal women.

Medicare beneficiaries experienced a median delay of 2.4 days between lung cancer diagnosis and initiation of chemotherapy in 2006.

Higher initial mortality is associated with antidepressant use.

Combination nicotine replacement therapies with varenicline or bupropion are not associated with significantly higher long-term abstinence rates at 52 weeks than varenicline monotherapy.

The risk of cancer is lower in individuals with a history of heavy alcohol consumption.

MEK inhibitors are not effective in RAS-driven mouse models of cancer.


Normal granulomas formed in the absence of TNF-␣ despite increased bacterial growth.

Choice of specialty is not influenced by debt accrued from medical training.

Excess nitric oxide is responsible for vasospasm.

Somatic missense mutations in NT5C2 are associated with relapse of acute lymphoblastic leukemia.

Whole brain radiotherapy reduces the occurrence of new brain metastases.

Persister cells lead to clinical relapse in cancer patients.

All phenotypes associated with reduced IIS require the gene daf-16.

Hematopoietic progenitor cells are never susceptible to HIV-1 infection ex vivo.

Tuberculosis-induced granulomas express immune system protein signatures similar to those of the surrounding tissue.

The tissue surrounding the granuloma in an immune cell induces an inflammatory immune response.

The center of the granuloma in an immune cell induces an anti-inflammatory immune response.

Transient IFN-γ exposure leads to long-lived infammatory responses in cancer cells due to IFN-γ retention on the cell surface.

Inside the body, falciparum parasites form agglomerates of infected cells to avoid spleen clearance.

Antibiotic induced alterations in the gut microbiome increase resistance against Clostridium difficile

G-CSF prevents MDSCs from infiltrating tumors.

Deletion of αvβ8 results in a spontaneous inflammatory phenotype.

T regulatory cells (tTregs) lacking αvβ8 are unable to suppress pathogenic T-cell responses during active inflammation.


Notch signalling can occur between tumor cells and stromal cells.

Pyridostatin delays checkpoint activation.

CHEK2 has a significant role in breast cancer

Phosphorylation of the ATM protein regulates DNA damage-induced neuronal death.

Teaching hospitals provide better care than non-teaching hospitals.

In the UK, drowning affects boys at a higher rate than girls.

Ginger is safe for mechanically ventilated patients.

Bronchial responsiveness is higher in the summer than in the winter.

Occipital activation levels are not correlated with auditory spatial performance in parietal regions of the brain.

A breast cancer patient's capacity to metabolize tamoxifen has no effect on treatment outcome.

C. elegans germlines lose their immortal character when nuclear RNAi is activated.

Deltex has been shown to interact with eIF3f, a DUB required for Notch activation process.

50% of patients exposed to radiation have activated markers of myofibroblasts.

C-Met is involved in epithelial-mesenchymal transition in tumor cells.

NLRP12 is a positive regulator of T-cell receptor activation.

Mitochondria play a major role in calcium homeostasis.

The balance between F- and G-actin regulates the orientation of neuronal migration in the developing cerebral cortex.

p53 controls autophagy through the AMPK/mTOR-dependent pathway.


Nrde-3 facilitates heritable silencing in C. elegans by transporting secondary siRNAs to the nucleus.

LSD1 plays a role in transcriptional activation

10-20% of people with severe mental disorder receive no treatment in low and middle income countries.

Near-infrared wavelengths increase penetration depth in fiberoptic confocal microscopy.

Oral ibandronate reduces relative risk of new vertebral fractures and clinical vertebral fractures in women.

Antibiotic induced alterations in the gut microbiome increase resistance against Clostridium difficile

The binding orientation of the ML-SA1 activator at hTRPML2 is similar to the binding orientation of the ML-SA1 activator at hTRPML1.

Rapamycin accelerates aging in fruit flies.

The myocardial cell lineage originally develops from cardiac progenitors of mesodermal origin.

Carriers of the alcohol aldehyde dehydrogenase deficiency mutation drink more that non-carries.

The center of the granuloma in an immune cell induces an anti-inflammatory immune response.

NR5A2 is important in bile acid homeostasis in humans.

Conformational changes of the CD3 complex enable ITAM phosphorylation.

S-nitrosylated GAPDH physiologically transnitrosylates target nuclear proteins.

C. elegans germlines lose their immortal character when nuclear RNAi is disabled.

C. elegans germlines lose their immortal character when nuclear RNAi is activated.

S-nitrosylated GAPDH physiologically transnitrosylates DNA-activated protein kinase.

The number of Ndc80 complexes varies with cell cycle timing.

All phenotypes associated with reduced IIS require the gene daf-16.


In the UK, drowning affects boys at a higher rate than girls.

PRC1-bound plasmids sediment at a faster rate in unbound plasmids than in sucrose gradients.

SOD1 integrates oxygen and glucose signals to repress cellular respiration.

In a naive state, blocking Wingless-Int-1 secretion from mouse embryonic stem cells encourages self-renewal of the mouse embryonic stem cells.

PEP carboxylase enhances threonine production in E. coli.

Bronchial responsiveness is the same in the winter and summer seasons.

Adult tissue-resident macrophages are maintained independent of circulating monocytes.

The appearance of brown-like or beige cells primarily occurs in subcutaneous fat, not visceral fat.

Cellular aging is uncorrelated with an older appearance.

Obesity is determined in part by genetic factors.

High cardiopulmonary fitness causes decreased mortality rate.

Low saturated fat diets have adverse effects on growth or development of infants.

Low saturated fat diets do not have adverse effects on growth or development of infants.

Suboptimal nutrition is a leading cause of chronic disease

Vitamin D deficiency has no effect on the term of child delivery.


Rapamycin accelerates aging in fruit flies.

Combining phosphatidylinositide 3-kinase and MEK 1/2 inhibitors is ineffective at treating KRAS mutant tumors.

Coordinated stabilization of kinetochore-microtubule attachments occurs at the prometaphase to metaphase transition.

Glucose restriction to 0.05% increases RLS (replicative life span) by 20-40% in S. cerevisiae.

Gastric lavage shows no benefit for acute paraquat poisoning.

Antibiotic induced alterations in the gut microbiome increase resistance against Clostridium difficile

All six cathelicidins are located on chromosome two.

Roughly one in twenty UK citizens harbor variant Creutzfeldt-Jakob disease prions in lymphoid tissues.

Bariatric surgery reduces resolution of diabetes.

Lysine histone demethylase inhibitor JIB 04 is primarily active against KDM5A.


Obesity is determined in part by genetic factors.

Presence of stemloops is important for reverse transcription in short interspersed nuclear elements (SINEs).

Excess nitric oxide is responsible for vasospasm.

De novo assembly of sequence data has longer contigs than unassembled sequence data.

Electromagnetic interference has no effect on Radio Frequency Identification (RFID) readability and reading distances.

Participating in six months of physical activity impairs cognitive functioning.

Falsified artemisinin family drugs with no active ingredient are generally safe.

The PDPN gene activates the C-type lectin receptor (CLEC-2).

Approximately 22,500 people are infected with human T-cell lymphotropic virus type 1 in the United Kingdom.

C. elegans germlines lose their immortal character when nuclear RNAi is activated.

RUNX is a top ranscription factor in skin tissue.

Ninety percent (90%) of kidney cancers in the UK are attributable to excess weight.

Genetic deficiency of mast cells leads to increased weight gain in a mouse model of diet-induced obesity.


The actual sequences of CP-1 and CR-5 regions are evolutionarily conserved throughout most eukaryotes.

MEK inhibitors are not effective in RAS-driven mouse models of cancer.

Cell autonomous sex determination in somatic cells does not occur in Passeriformes.

LSD1 plays a role in transcriptional activation

PEP carboxylase enhances threonine production in E. coli.

CRY proteins mediate light signal transduction.

MUC1-C inhibits the NF-κB p65 signaling pathway by interacting with IκB kinase ß.

An N-formyl group on M3 molecules suppresss strong binding to the second position of the groove.

Correlative electron microscopy and superresolution fluorescence imaging are imaging techniques.

Rates of hypertension in patients type 2 diabetes mellitus are similar to those in non-diabetic subjects.

Decreases in region specific aerobic glycolysis in aged humans causes aging induced changes in brain glucose metabolism.

Cellular aging is uncorrelated with an older appearance.


Esrrb associates with BAF and Mbd3/NURD complexes.

Low saturated fat diets have adverse effects on growth or development of infants.

The number of unfertilized oocytes in mated hermaphrodites decreases with age.

Low saturated fat diets do not have adverse effects on growth or development of infants.

Supracellular actomyosin structures are found at boundaries in Drosophila wing imaginal discs.

CENP-B inhibits heterochromatin formation

Osteocytes are not associated with G-CSF induced HSPC mobilization.

Lysine histone demethylase inhibitor JIB 04 is primarily active against KDM5A.

Hypertension can be accurately diagnosed with ambulatory blood pressure monitoring.


Occipital activation levels are not correlated with auditory spatial performance in parietal regions of the brain.

Hematopoietic progenitor cells are never susceptible to HIV-1 infection ex vivo.

A deficiency of vitamin B6 increases blood levels of homocysteine.

Pseudoknots alter gene expression by inducing ribosomal frameshifts in viruses.

Taking anti-depresents is associated with a increase in the Aβ level in the brain of experimental animals.

Coordinated stabilization of kinetochore-microtubule attachments occurs at the prometaphase to metaphase transition.

Athletes with or without a concussion have smaller volumes of hippocampal gray matter compared to healthy controls.

The ring complexes of chromosomes in C. elegans oocytes are built in discrete layers.

Presence of stemloops is important for reverse transcription in short interspersed nuclear elements (SINEs).

There are four spatial channels in each hemifield of the auditory cortex of cats.

Serotonin receptors have no effect on depression

Serotonin receptors play a role in depression

The balance between F- and G-actin regulates the orientation of neuronal migration in the developing cerebral cortex.

Electrophysiological changes in motor neurons have been observed in patients with amyotrophic lateral sclerosis.

Synaptic activity enhances local synthesis of brain derived neurotrophic factor from postsynaptic dendrites.

Synaptic activity impairs local release of brain derived neurotrophic factor from postsynaptic dendrites.

Motor neurons from patients with amyotrophic lateral sclerosis have electrophysiological changes relative to healthy patients.


Oral ibandronate increases relative risk of new vertebral fractures and clinical vertebral fractures in women.

Rates of hypertension in patients type 2 diabetes mellitus are similar to those in non-diabetic subjects.

Inhibiting HDAC6 decreases survival of mice with ARID1A mutated tumors.

Self-advocacy training is not effective at decreasing homelessness.

Phosphorylation of the ATM protein regulates DNA damage-induced neuronal death.

DUSP4 downregulation activates the Ras-ERK pathway

The binding orientation of the ML-SA1 activator at hTRPML2 is similar to the binding orientation of the ML-SA1 activator at hTRPML1.

Supracellular actomyosin structures are found at boundaries in Drosophila wing imaginal discs.

25% of patients with melanoma and an objective response to PD-1 blockade will experience a progression in their melanoma.

RUNX is a top ranscription factor in skin tissue.

Oral ibandronate reduces relative risk of new vertebral fractures and clinical vertebral fractures in women.

Risedronate reduces risk of vertebral and non-vertebral fractures.

Side effects associated with antidepressants increases risk of mortality in postmenopausal women.

Side effects associated with antidepressants decrease risk of stroke.

A breast cancer patient's capacity to metabolize tamoxifen has no effect on treatment outcome.

Side effects associated with antidepressants increases risk of myocardial infarction.

Amitriptyline ineffective as a treatment for chronic tension-type headaches.

AZT given with ribavirin alleviates anemia.

Higher initial mortality is associated with antidepressant use.


Oral ibandronate reduces relative risk of new vertebral fractures and clinical vertebral fractures in women.

Hematopoietic progenitor cells are never susceptible to HIV-1 infection ex vivo.

Hypoglycemia decreases the risk of dementia.

Tet enzymes activate microRNAs required for iPSC derivation.

In rhesus macaques, daily subcutaneous injections of emtricitabine protect against rectally transmitted simian-human immunodeficiency virus.

Thigh-length graduated compression stockings (GCS) reduced deep vein thrombosis in patients admitted to hospital who are immobile because of acute stroke.

Side effects associated with antidepressants increases risk of myocardial infarction.

Synaptic activity impairs local release of brain derived neurotrophic factor from postsynaptic dendrites.

Satellite cell dysfunction is not a key factor in sarcopenia development.

Combination nicotine replacement therapies with varenicline or bupropion are not associated with significantly higher long-term abstinence rates at 52 weeks than varenicline monotherapy.


Osteocytes are not associated with G-CSF induced HSPC mobilization.

25% of patients with melanoma and an objective response to PD-1 blockade will experience a progression in their melanoma.

Pretreatment with the Arp2/3 inhibitor CK-666 is not associated with lamelliopodia formation.

C. elegans germlines lose their immortal character when nuclear RNAi is disabled.

Amitriptyline ineffective as a treatment for chronic tension-type headaches.

Adipocytes in major adipose depots descend from cells with a history of Pdgfra expression.

Transplanted human glial cells are incapable of differentiation within the host animal.

Transplanted human glial progenitor cells can form a neural network with host animals' neurons.

Replacement of OCT4 and SOX2 genes with mesendoderm-related genes has the ability to reprogram human cells.

Valproic acid (VPA) treatment allows reprogramming by the microRNA cluster miR302/367.

A deficiency of vitamin B6 increases blood levels of homocysteine.

G-CSF prevents MDSCs from infiltrating tumors.

GEF-H1 activates RhoA in response to extracellular signal-regulated kinase activation.

Increased calcium levels activate transgultaminase activity.

The balance between F- and G-actin regulates the orientation of neuronal migration in the developing cerebral cortex.

Rapamycin treatment raises G-CSF levels.

Differentiated E2f-1, -2, -3 TKO cells in the intestine can exhibit apoptosis.

Mitochondria play a major role in calcium homeostasis.

Pyridostatin increases telomere fragility in BRCA2-deficient cells.

Increased calcium levels repress transgultaminase activity.


PEP carboxylase enhances threonine production in E. coli.

A deficiency of vitamin B6 increases blood levels of homocysteine.

Bariatric surgery has a deleterious impact on mental health.

The binding orientation of the ML-SA1 activator at hTRPML2 is similar to the binding orientation of the ML-SA1 activator at hTRPML1.

Consumption of whole fruits reduces the risk of type 2 diabetes.

Cellular aging is uncorrelated with an older appearance.

C. elegans germlines lose their immortal character when nuclear RNAi is activated.

Near-infrared wavelengths decrease penetration depth in fiberoptic confocal microscopy.

Participants who quit smoking reduce lung cancer risk by approximately 5%.

Infection of human T-cell lymphotropic virus type 1 is most frequent in individuals of European origin.

Carriers of the alcohol aldehyde dehydrogenase deficiency mutation drink more that non-carries.

PEP carboxylase suppresses threonine production in E. coli.

Aspirin encourages the production of PGE2.

Inhibiting glucose-6-phospate dehydrogenase impairs lipogenesis by reactivating LKB1-AMPK signaling.

V-9302 causes antitumor responses by increasing cell death and oxidative stress.

A deficiency of folate decreases blood levels of homocysteine.

MUC1-C inhibits the NF-κB p65 signaling pathway by interacting with IκB kinase ß.

Nitric oxide (NO) can S- nitrosylate G protein-coupled receptor kinases (GRKs) to suppress their activity and block phosphorylation.

Long chain polyunsaturated fatty acids supplementation is associated with higher rates of atopic eczema at 1 year.


PEP carboxylase suppresses threonine production in E. coli.

Rates of hypertension in patients type 2 diabetes mellitus are similar to those in non-diabetic subjects.

There is a neuroprotective effect of Trpm4 inhibition in mice and rats.

Verbal autopsy (VA) performed well in distinguishing between different injury categories in the elderly population.

Long chain polyunsaturated fatty acids supplementation is associated with lower rates of allergic sensitization  at 1 year.

Vitamin D deficiency has no effect on the term of child delivery.

PEP carboxylase enhances threonine production in E. coli.

High methylation levels within individual DNA molecules correlates with high nucleosome occupancy across species.

The tissue surrounding the granuloma in an immune cell induces an inflammatory immune response.

Tet enzymes activate microRNAs required for iPSC derivation.

Lysine histone demethylase inhibitor JIB 04 is primarily active against KDM5A.


PRC1-bound plasmids sediment at a faster rate in unbound plasmids than in sucrose gradients.

S-nitrosylated GAPDH physiologically transnitrosylates target nuclear proteins.

Broadly HIV-1 Neutralizing Antibodies (bnAb) 10EB exhibit a strong affinity for phospholipids.

The first MBT repeat of the four malignant brain tumor (4MBT) domain of Drosophila's Sfmbt and of the orthologous mammalian L3MBTL2 is nonessential for the interaction with the spacer region of Drosophila's Pleiohomeotic (Pho) or its human ortholog YY1.

Having a main partner increases survival rates in HIV patients.

Sweet taste receptors on the tongue are activated by between 300 and 1000 mM glucose.

Increased calcium levels activate transgultaminase activity.

Tuberculosis incidence is correlated with residential crowding in the UK.

Ninety percent (90%) of kidney cancers in the UK are attributable to excess weight.

Synaptic activity impairs local synthesis of brain derived neurotrophic factor from postsynaptic dendrites.

Chikungunya virus (CHIKV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in mice.

The ring complexes of chromosomes in C. elegans oocytes are built in discrete layers.

CENP-B inhibits heterochromatin formation

Proteins synthesized at the growth cone are ubiquitinated at a lower rate than proteins from the cell body.

Ultrafine Anaphase Bridges represent a mechanism for resolving partially-replicated stretches of DNA.

β1/Ketel is unable to bind microtubules.

Pyridostatin increases telomere fragility in BRCA2-deficient cells.

Coordinated stabilization of kinetochore-microtubule attachments occurs at the prometaphase to metaphase transition.

Supracellular actomyosin structures are found at boundaries in Drosophila wing imaginal discs.

The actual sequences of CP-1 and CR-5 regions are evolutionarily conserved throughout most eukaryotes.


Participants who quit smoking reduce lung cancer risk by approximately 5%.

Near-infrared wavelengths decrease penetration depth in fiberoptic confocal microscopy.

CRY proteins mediate light signal transduction.

Oral ibandronate increases relative risk of new vertebral fractures and clinical vertebral fractures in women.

Pretreatment with the Arp2/3 inhibitor CK-666 is not associated with lamelliopodia formation.

C-Met is involved in epithelial-mesenchymal transition in tumor cells.

C. elegans germlines lose their immortal character when nuclear RNAi is disabled.

Autologous transplantation of mesenchymal stem cells has higher rates of rejection than induction therapy with anti-interleukin-2 receptor antibodies.

V-9302 causes antitumor responses by increasing cell death and oxidative stress.

Low saturated fat diets do not have adverse effects on growth or development of infants.

Pattern recognition receptors are transcripts determinant for resistance to Plasmodium infection.

The risk of cancer is lower in individuals with a history of heavy alcohol consumption.

Medicare beneficiaries experienced a median delay of 2.4 days between lung cancer diagnosis and initiation of chemotherapy in 2006.

Higher initial mortality is associated with antidepressant use.

Combination nicotine replacement therapies with varenicline or bupropion are not associated with significantly higher long-term abstinence rates at 52 weeks than varenicline monotherapy.

Incidence rates of cervical cancer have increased over time.

No strong relationship has been found with Pioglitazone use and increased risk for pancreatic cancer

Side effects associated with antidepressants decrease risk of stroke.

Female carriers of the Apolipoprotein E4 (APOE4) allele have a reduced risk for Alzheimer's disease.

Side effects associated with antidepressants increases risk of mortality in postmenopausal women.