Pseudoknots are not evolutionarily conserved in most eukaryotes.

Roughly 55% of women with chronic pelvic pain have no underlying pathology.

The first MBT repeat of the four malignant brain tumor (4MBT) domain of Drosophila's Sfmbt and of the orthologous mammalian L3MBTL2 is required for the interaction with the spacer region of Drosophila's Pleiohomeotic (Pho) or its human ortholog YY1.

Over half of the gabonese children with Schimmelpenning-Feuerstein-Mims syndrome (SFM) had a plasma lactate of more than 5mmol/L.

Pioneer factor OCT3/4 interacts with major chromatin remodeling factors.

The PRDM1 gene, when combined with the PRDM14 gene, plays an important role during primordial germ cell specification.

Induction of urokinase receptor signaling in podocytes causes foot process effacement and proteinuria.

Destination container port throughput(CPT) is positively related to dengue virus (DENV-1) diffusion in air traffic shipments.

Major vault protein (MVP) leads to more aggressive tumors by regulating the sorting of tumor suppressive miR-193a into extracellular vesicles (EVs).

Tirasemtiv has no effect on cardiac muscle.

Myelin sheaths are lipid-rich cellular structures.

Pre-mRNAs associated with spliceosomal components are less stable than unassociated splicing substrates.

Pre-mRNAs associated with spliceosomal components are more stable than unassociated splicing substrates.

Genes involved in pre-mRNA splicing have a significant impact on genome stability.

mcm 5 s 2 U is required for proper decoding of NNR codons in eukaryotes.

Ribosomopathies have a high degree of cell and tissue specific pathology.

miRNAs enforce homeostasis by suppressing low-level ''leaky'' transcription.

Sequence conservation in gene regulatory regions between species is a poor predictor of conserved functionality.

Sequence conservation in gene regulatory regions between species is a high-accuracy predictor of conserved functionality.

Low nucleosome occupancy correlates with high methylation levels across species.


Pure neural progenitor cell (NPC) populations can only be obtained from cell cultures that undergo passaging, filtration, or other isolation and cell sorting methods.

Medications to treat obesity do not have side effects.

There is a positive correlation between hip fractures and statin use.

AZT given with ribavirin increases anemia.

Measuring routine outcomes is more beneficial to clinical practice than assessing treatment adherence.

MICAL redox enzymes regulate actin dynamics.

Monoclonal antibody targeting of N-cadherin inhibits growth.

The morphology change from large white adipocytes to small brown adipocytes is a sign of increased energy expenditure potential in white adipose tissue.

COPI coatmer is involved in lipid homeostasis.

HbA1c consistently overestimates glycemic control in black individuals with Sickle cell trait (SCT).

TNFAIP3 is a glioblastoma tumor enhancer.

The proliferative capacity of neural progenitors differs across species.

The proliferative capacity of progenitors is regulated cell-autonomously.

0-dimensional biomaterials lack inductive properties.

Human embryonic stem cells have the capacity to give rise to differentiated progeny representative of all three embryonic germ layers.

Human embryonic stem cells give rise to cell types from the outer embryonic germ layer, but not the other two layers.

Upregulation of dynein in Drosophila neurons increases the number of microtubule plus-ends growing toward the cell body of each neuron.

Environmentally-induced senescence is mimicked in disease modeling by adding specific molecules to the culture system.

HIV trans-activator protein (TAT) effectively transports large and small molecules across cellular membranes into larger populations of neurons.

Nuclear transfer from adult human fibroblasts to human oocytes can give rise to blastocysts containing expandable pluripotent cells.


Pyridostatin decreases telomere fragility in BRCA2-deficient cells.

Systemic lupus erythematosus is a risk factor for cardiovascular disease.

Cholesterol loading induces KLF4 expression in VSMCs, resulting in the expression of pro-inflammatory cytokines.

Increased flux of microbial products provokes immune responses.

Certain immunomodulator-human dialyzable leukocyte extract (hDLE) peptides are recognized by toll-like receptors (TLRs) on macrophages and dendritic cells.

N348I mutations reduce resistance to nevirapine.

Increased microtubule acetylation repairs interference of axonal transport caused by LRRK2 Roc-COR domain mutations.

PRC1-bound plasmids sediment at a slower rate in unbound plasmids than in sucrose gradients.

The innate immune response struggles to remove small numbers of parasites.

ART has no effect on the infectiveness of HIV-positive people.

Pyridostatin stabilizes the G - quadruplex in the telomeric region.

Pyridostatin induces double-strand breaks accumulation.

Pyridostatin prevents double-strand breaks accumulation.

Pyridostatin reduces proliferation of homologous recombination - defective cells.

Pyridostatin deregulates G2/M progression.

Pyridostatin encourages proliferation of homologous recombination - defective cells.

Pyridostatin induces checkpoint activation.

Reduced phosphorylation of PP2A increases HDAC4 dephosphorylation by enhancing PP2A-HDAC4 interaction.

The C-type lectin receptor (CLEC-2) rearranges the actin cytoskeleton in dendritic cells to promote efficient motility along stromal surfaces.


Pyridostatin deregulates G2/M progression.

Lamins are associated with nuclear membrane structure maintenance.

The tip of the inner tube of the toxic type VI secretion system (T6SS) antibacterial effector in Escherichia coli (E. coli) is decorated with VgrG and PAAR proteins.

Pediatric SCD patients with vaso-occlusive crisis show increased morphine use after breathing 80 ppm iNO for 4 hours.

Ten percent (10%) of kidney cancers in the UK are attributable to excess weight.

F4/80+ macrophages regulate mature osteoblast maintenance.

Concentrations of SNV and CNV in stem-cell regulatory elements and binding sites of transcription factors in iPSC-lines are distinct from their founding cells.

Students who perform poorly in the early years of medical school are less likely to commit professional misconduct later in their careers.

4-PBA treatment decreases endoplasmic reticulum stress in response to general endoplasmic reticulum stress markers.

Ribosomal protein (RP) expression is controlled in part by stress-activated regulators.

Inhibiting focal adhesion formation enables cells to convert mechanical strain into eventual scarring.

Mutations in G-Beta protein GNB1 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.

The deamination of cytidine to uridine on the minus strand of viral DNA can inactivate the viral genome by inducing G-to-A mutations.


Pyridostatin encourages proliferation of homologous recombination - defective cells.

Environmentally-induced senescence is mimicked in disease modeling by adding specific molecules to the culture system.

PrimPol generates short DNA replication intermediates on the leading strand during DNA replication.

Eliminating the last sporadic cases of malaria requires considerable funding.

In patients with congenital heart defects, β-blockers significantly improve clinical heart failure outcomes.

The peak incidence of fractures occurs in toddlers.

Tumor development occurs in conjunction with upregulation of pro-inflammatory cytokines.

Foxp3 enables the expression of transcriptional regulators implicated in memory T cell development.

Ultrasound guidance significantly reduces the number of needle insertion attempts necessary for a given procedure.

Sepsis related mortality has risen from 2009 to 2014.

Genomic aberrations of metastases provide information for targeted therapy.

Cyclin A2 destruction is necessary to switch from unstable to stable kt-mt attachments in mitosis.


Pyridostatin induces checkpoint activation.

mcm 5 s 2 U is required for proper decoding of NNR codons in eukaryotes.

Cost effectiveness evaluations based on cRCT data lack external validity.

Adult tissue-resident macrophages stem from the embryonal yolk sac and fetal liver.

1-1% of colorectal cancer patients are diagnosed with regional or distant metastases.

Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes fibrosis.

The ability of activator E2Fs in preventing cell death is limited to terminally differentiated cells.

The minor G allele of FOXO3 up-regulates IL-10.

Pseudogene PTENP1 encodes a transcript that regulates PTEN expression.

taa1 tar1 tar2 triple mutants in Arabidopsis do not make root meristem during embryogenesis.

Chemical injury represses transglutaminase 2 activity.


Pyridostatin induces double-strand breaks accumulation.

Cost effectiveness evaluations based on cRCT data lack external validity.

miR-142-5P is a known regulator of raised body temperature.

MafA phosphorylation decreases its ubiquitination.

Ca2+ cycling is a UCP1-dependent thermogenic mechanism.

Increased flux of microbial products provokes immune responses.

Major antigen-induced signals from the T cell receptor and secondary signals from costimulatory receptors are required for T cell activation.

Mice defective for deoxyribonucleic acid (DNA) polymerase m (polm) fail to reveal increased sensitivity to ionizing radiation (IR).

Adult tissue-resident macrophages are seeded before birth.

Pediatric SCD patients with vaso-occlusive crisis show increased morphine use after breathing 80 ppm iNO for 4 hours.

RAD52 is involved in break-induced DNA replication (BIR).


Pyridostatin prevents double-strand breaks accumulation.

Urbanization is an important risk factor related to the transmission of dengue fever.

CDK6 shows impaired binding to loss-of-function variants of p18 INK4C.

TRAP+ osteoclasts regulate mature osteoblast maintenance.

Patients with common epithelial cancers  are more likely to have an emergency event as their first hospital admission if they live in resource-deprived areas.

Active Ly49Q prevents neutrophil polarization.

Physical injury represses transgultaminase activity.

Low expression of miR7a does not repress target genes or exert a biological function in testis.

Lipopolysaccharides have an inflammation independent effect on kidney barrier function.

Glioblastoma multiforme (GBM) is characterized by extensive invasion, rapid growth, necrosis, and angiogenesis.

Intra-cerebroventricular infusion of amyloid-β oligomers increases expression of fibronectin type-III domain-containing protein 5 mRNA in mice hippocampi.


Pyridostatin reduces proliferation of homologous recombination - defective cells.

Environmentally-induced senescence is mimicked in disease modeling by adding specific molecules to the culture system.

The Snf1 complex regulates carbon and energy metabolism in baker's yeast (Saccharomyces cerevisiae).

Insulin decreases risk of severe kidney failure.

Risedronate increases risk of vertebral and non-vertebral fractures.

Patients with common epithelial cancers are less likely to have an emergency event as their first hospital admission if they live in resource-deprived areas.

Sepsis related mortality has remained stable between 2009-2014.

Replacement of OCT4 and SOX2 genes with GATA3 is not capable of reprogramming human cells.

The PPR MDA5 has twenty N-terminal CARD domains.

Long chain polyunsaturated fatty acids supplementation is associated with lower rates of atopic eczema at 1 year.

Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection decreases dissemination of Salmonella Typhimurium from the gut.


Pyridostatin stabilizes the G - quadruplex in the telomeric region.

Prescribed exercise training improves quality of life.

Taxation of sugar-sweetened beverages reduced the incidence rate of type II diabetes in India.

Normal granulomas form in the presence of TNF in Zebrafish.

AZT given with ribavirin increases anemia.

50% of patients exposed to radiation have activated markers of mesenchymal stem cells.

The generation of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells.

ERAP1 SNPs are epistatic to HLA alleles for ankylosing spondylitis.

Satellite cell dysfunction is a key factor in sarcopenia development.

Lipopolysaccharides have an inflammation independent effect on kidney barrier function.

In the UK, drowning affects boys and girls equally.

Formation of N-terminal pyroglutamate by glutamine cyclase (GC) competes with NTAQ1 for Nt-Gln substrates.

Oxidative phosphorylation is one of the primary glycometabolic pathways in cells.


R2D2 stops miRNA production by increasing the selectivity of Dcr2 for long dsRNA.

The NF-κB essential modulator gene prevents intestinal inflammation by inhibiting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death.

Women are more susceptible to death due to pneumonia when compared to men.

Pyridostatin decreases telomere fragility in BRCA2-deficient cells.

Upon viral challenge, influenza-specific memory CD4+ T cells greatly enhance the early production of inflammatory chemokines in the lung.

Toll-like receptor (TLR) signaling is involved in the pathogenesis of human MDS.

Varying expression levels of EBI2 affect the positioning and migration of B cells.

The recruitment of Wdr5 to its target loci depends on Kat8.

The myocardial cell lineage originally develops from cardiac progenitors of exclusively endodermal origin.

Systemic immunosuppressive (IS) therapy increases the chance of cancer mortality in patients with inflammatory eye disease (IED)

The PPR MDA5 has twenty N-terminal CARD domains.

mcm 5 s 2 U is required for proper decoding of NNR codons in eukaryotes.

N348I mutations cause resistance to nevirapine.

Low expression of miR7a does not repress target genes or exert a biological function in testis.

Low expression of miR7a does not repress target genes or exert a biological function in ovaries.

N348I mutations reduce resistance to nevirapine.

miR-142-5P is a temperature-sensitive microRNA (miRNA).

Gpr124 suppresses BBB breakdown in mouse models of ischemic stroke.


RA activation of DIF2 and NB4 cells induces hallmarks of transcriptionally active promoters.

0-dimensional biomaterials lack inductive properties.

The most prevalent adverse events to Semaglutide are cardiovascular.

Mitochondria play a major role in apoptosis.

Increased microtubule acetylation exacerbates LRRK2 Roc-COR domain mutation induced locomotor deficits.

Gpr124 increases BBB breakdown in mouse models of ischemic stroke.

Microglia are an innate immune cell type of the peripheral nervous system.

Pyridostatin encourages proliferation of homologous recombination - defective cells.

Patients in stable partnerships progress from HIV to death at the same rate as patients not in partnerships.

Up-regulation of the p53 pathway and related molecular events speeds cancer progression.

Rhythmic expression of Cry1 translates directly into a circadian regulation of cAMP signaling in hepatic glucose metabolism.

LSD1-positive promoters are associated with RNA polymerase II

Replacement of histone H2A with H2A.Z accelerates gene activation in yeasts by destabilizing +1 nucleosomes.

Binding of p53 to enhancer regions (p53BERs) regulates the activity of p53 transcription and cell cycle arrest through the production of p53-dependent eRNAs.

B3-Galectin decreases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR.

B3-Galectin increases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR.

Activated Cdk5 regulates DNA damage-induced neuronal death.

Long - range chromatin interactions regulate transcription.

The repeat-variable diresidue (RVD) in the loop of Transcription-Activator Like (TAL) effectors specifies the nucleotides-amino acid contact at the target promoter element.

Mutations in G-Beta protein GNB1 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.


RAD52 is involved in break-induced DNA replication (BIR).

Pioglitazone use is not associated with an increased risk of prostate cancer.

V-9302 inhibits antitumor responses by decreasing cell death and oxidative stress.

Deletion of ATM and Rad3 related protein is not predictive of acute tissue loss.

Taking 400mg of α-tocopheryl acetate does not prevent prostate cancer.

Pharmacist attendance at ward rounds reduces adverse events in wards.

Individuals with low serum vitamin D concentrations have decreased risk of multiple sclerosis.

Comparative transcriptome analysis identified new platelet proteins with structural features suggesting a role in platelet function.

Post-transcriptional handling of mitochondrial transcripts occurs in mitochondrial RNA granules.

MafA phosphorylation enhances its ubiquitination.

ATM and Rad3 related protein are critical for sensing DNA damage.

ATM and Rad3 related protein have no role in sensing DNA damage.

The PPR MDA5 has twenty N-terminal CARD domains.

Genes involved in pre-mRNA splicing have a significant impact on genome stability.

Mutations in RIM1 decrease levels of IME1 RNA.

Mutations in RIM1 raise levels of IME1 RNA.

BLM gene encodes RecQ-class DNA helicase.

Toll-like receptor (TLR) signaling is involved in the pathogenesis of human MDS.


RANK-RANKL pathway signalling has no known association with development of Aire-expressing medullary thymic epithelial cells.

Treatment with a protein named FN impairs regenerative abilities of aged muscles.

Reduced phosphorylation of PP2A increases HDAC4 dephosphorylation by enhancing PP2A-HDAC4 interaction.

siRNA knockdown of A20 slows tumor progression in an in vivo murine xenograft model.

Cancer cells can stimulate the accumulation of intra-tumoural myeloid-derived suppressor cells by promoting granulocyte colony stimulating factor production.

Tuberculosis-induced granulomas express different immune system protein signatures than the surrounding tissue.

Pioneer factor OCT3/4 interacts with major chromatin remodeling factors.

Patients with panic anxiety show decreased CSF levels of hypocretin.

Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 inhibit West Nile virus replication in cortical neurons.

FACT and other histone chaperone(s) compensate for Histone 2A (H2A)-histone 2B (H2B) dimer eviction during the histone exchange process.

ScPif1p has reduced binding ability to G-rich ssDNA compared to non-G-rich ssDNA.

The RANK-RANK-Ligand (RANKL) pathway is involved in the development of Aire-expressing medullary thymic epithelial cells (mTECs).

RANK-RANKL pathway signalling is linked to development of Aire-expressing medullary thymic epithelial cells.

KRT17 modulates the expression of the transcriptional regulator AIRE in diseased epithelia.

AMP-activated protein kinase (AMPK) activation reduces inflammation-related fibrosis in the lungs.

The NF-κB essential modulator gene induces intestinal inflammation by promoting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death.

The NF-κB essential modulator gene prevents intestinal inflammation by inhibiting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death.

ITAM phosphorylation allows for the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).

Inhibiting glucose-6-phospate dehydrogenase improves lipogenesis by deactivating LKB1-AMPK signaling.

Ly6C hi monocytes have a higher inflammatory capacity than Ly6C lo monocytes.


RANK-RANKL pathway signalling is linked to development of Aire-expressing medullary thymic epithelial cells.

Immune complex triggered cell death leads to sequestration of oxidized mitochondrial DNA.

A breast cancer patient's capacity to metabolize tamoxifen influences treatment outcome.

Lamins have no effect on nuclear membrane structure maintenance.

Patients in stable partnerships progress from HIV to death at the same rate as patients not in partnerships.

The appearance of brown-like or beige cells primarily occurs in visceral fat, not subcutaneous fat.

Long chain polyunsaturated fatty acids supplementation reduces wheezing and asthma.

Ectopic expression of Sall4, Nanog, Esrrb, and Lin28 generates induced pluripotent stem cells from mouse embryonic fibroblasts more efficiently than other factor combinations.

Distant CREs are important for transcriptional regulation.

The deregulated and prolonged activation of monocytes has deleterious effects in chronic infectious conditions.

The DEXI promoter region is bound by multiple transcription factors in a murine haematopoietic progenitor cell line.

Occipital activation levels are associated with auditory spatial performance in parietal regions of the brain.

Rhythmic expression of Cry1 translates directly into a circadian regulation of cAMP signaling in gluconeogenesis.


RTEL1 interacts with TRF2 through a C4C4 motif

Mutations in RIM1 raise levels of IME1 RNA.

90% of patients with melanoma and an objective response to PD-1 blockade will experience a progression in their melanoma.

Lysine histone demethylase inhibitor JIB 04 is inactive against KDM5A.

The artifactual C-terminal helix swapping in the StART domain is observed in the Ups1-Mdm35 heterodimer of the StARkin superfamily.

BCL-2 promotes the apoptotic effects of c-Myc.

50% of patients exposed to radiation have activated markers of mesenchymal stem cells.

Mice defective for deoxyribonucleic acid (DNA) polymerase m (polm) fail to reveal increased sensitivity to ionizing radiation (IR).

Ca2+ cycling is a UCP1-independent thermogenic mechanism.

Cancer-associated fibroblasts (CAFs) are constituents of tumor microenvironments

Deltex interacts with eIF3. There is no known interaction between Deltex and elF3

The PDPN gene deactivates the C-type lectin receptor (CLEC-2).

The C-type lectin receptor (CLEC-2) rearranges the actin cytoskeleton in dendritic cells to promote efficient motility along stromal surfaces.

The TRaF1/C5 rs10818488 allele polymorphism regulates the neighboring C5 gene.

ATF4 is a general endoplasmic reticulum stress marker.

Activated Cdk5 phosphorylates the ATM protein in response to DNA damage.

Deltex has no known interactions with eIF3f.

DUSP4 downregulation deactivates the Ras-ERK pathway

MUC1-C activates the NF-κB p65 signaling pathway by interacting with IκB kinase ß.


The PDPN gene deactivates the C-type lectin receptor (CLEC-2).

PrimPol degrades short DNA replication intermediates on the leading strand during DNA replication.

Tonic signaling from the scFv prevents constitutive stimulation.

Combination nicotine replacement therapies with varenicline or bupropion are more effective after 12 weeks of reatment compared to varenicline monotherapy.

Differentiation of progenitor cells to myeloid cells is skewed upon activation of insulin signaling.

Physical activity level is associated with the difference in maximal oxygen consumption between black and white youth.

Nigerian physicians constitue the largest component of sub-Saharan Africa-trained physicians in the United States.

Lamins are associated with nuclear membrane structure maintenance.

Decrease of p62 in prostate tumor stroma results in defective autophagy.

Many transmembrane receptors transmit signals by long-range conformational changes in the association of alpha-helices across the plasma membrane.

Normal expression of RUNX1 causes tumorsupressing effects.

RUNX1 is downregulated or mutated in TLX1 T-ALL.

PD-1 triggering on monocytes enhances IL-10 production by monocytes.

Less than 10% of patients exposed to radiation have activated markers of mesenchymal stem cells.

ALDH1 expression is associated with poorer prognosis for breast cancer primary tumors.

Perigenital skin is not the primary site of HIV acquisition.

IL-10 production by monocytes inhibits CD4 + T cell response.

KRT17 modulates the expression of the transcriptional regulator AIRE in diseased epithelia.

50% of patients exposed to radiation have activated markers of mesenchymal stem cells.


RUNX1 is downregulated or mutated in TLX1 T-ALL.

Varying expression levels of EBI2 affect the positioning and migration of B cells.

Transplanted human glial progenitor cells can mature in their host animal.

Patients with microcytosis and higher erythrocyte count are more vulnerable to severe malarial anaemia when infected with Plasmodium falciparum.

M. stadtmanae does not induce ASC speck formation in BlaER1 monocytes.

Chinese individuals with TT homozygosity in the MTHFR gene are less vulnerable to strokes caused by low levels of folate intake.

Ectopic expression of Sall4, Nanog, Esrrb, and Lin28 generates induced pluripotent stem cells from mouse embryonic fibroblasts more efficiently than other factor combinations.

One in two surgical randomized controlled trials are discontinued early.

Expression of MSX2 is induced 3 hours after the addition of BMP4, which is earlier than T and CDX2.

Oat tolerant coeliac patients may have oat specific inflammatory cells in their small bowel mucosa.

Type 1 Diabetes is associated with subtle perturbations in T reg development.

Reduced responsiveness to interleukin-2 in regulatory T cells is associated with autoimmune diseases such as Type 1 Diabetes.

Major antigen-induced signals from the T cell receptor and secondary signals from costimulatory receptors are required for T cell activation.

Foxp3 represses the expression of transcriptional regulators implicated in memory T cell development.

In pediatric tissue, most T cells are naive T cell emigrants from the thymus.

Foxp3 enables the expression of transcriptional regulators implicated in memory T cell development.


Radioiodine treatment of non-toxic multinodular goitre increases thyroid volume.

Activated Cdk5 phosphorylates the ATM protein in response to DNA damage.

KRT17 modulates the expression of the transcriptional regulator AIRE in diseased epithelia.

Stacking is more stable when a purine is present in the +5 position (C1698).

Pro-inflammatory cytokines are up repressed during tumor development.

Reduced responsiveness to interleukin-2 in regulatory T cells is associated with autoimmune diseases such as Type 1 Diabetes.

HOXB4 facilitates HSC expansion when co-cultured with HSCs.

Stiff substrates inhibit mesodermal differentiation by degrading beta-catenin in an integrin-dependent manner.

Normal expression of RUNX1 causes tumorsupressing effects.

PrimPol generates short DNA replication intermediates on the leading strand during DNA replication.

Phase information is useful for predicting donor-recipient matches in organ transplantation.

Metastatic colorectal cancer treated with a single agent fluoropyrimidines resulted in similar efficacy and better quality of life when compared with oxaliplatin-based chemotherapy in elderly patients.

Thiopurine active metabolites can be catabolized through dephosphorylation of thioguanine nucleotides.

A deficiency of folate increases blood levels of homocysteine.

Increased vessel density along with a reduction in fibrosis improves the efficacy of chemotherapy treatments.

In breast cancer, the loss of myoepithelial cells slows the transition of ductal carcinoma in situ to invasive carcinoma.

40mg/day dosage of folic acid and 2mg/day dosage of vitamin B12 does not affect chronic kidney disease (CKD) progression.

In breast cancer, the loss of myoepithelial cells promotes the transition of ductal carcinoma in situ to invasive carcinoma.

Dexamethasone increases risk of postoperative bleeding.

Risk of cardiovascular events can be cut by a third by using antihypertensive drug therapy among hemodialysis patients.


aPKCz causes tumour suppression by affecting glutamine metabolism.

Early patent ductus ateriosus (PDA) screening increases in-hospital mortality.

Incidence of heart failure increased by 10% in women since 1979.

Ca2+ cycling controls whole-body energy homeostasis in beige fat.

90% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.

Over half of the gabonese children with Schimmelpenning-Feuerstein-Mims syndrome (SFM) had a plasma lactate of more than 5mmol/L.

Having a main partner worsens HIV outcomes.

Oxidative phosphorylation is one of the primary glycometabolic pathways in cells.

Deltex interacts with eIF3. There is no known interaction between Deltex and elF3

Mice that lack Interferon-γ or its receptor are highly susceptible to experimental autoimmune myocarditis.

Rapamycin increases the concentration of triacylglycerols in fruit flies.

Ethanol stress increases the expression of IBP in bacteria.

Inside the body, falciparum parasites reproduce asexually.

Progerin induces premature aging in stem cells.

Autophagy deficiency in the liver increases vulnerability to insulin resistance.

Omnivores produce less trimethylamine N-oxide from dietary I-carnitine than vegans.

Omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegans.

Omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegetarians.

Sildenafil worsens erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.


Rapamycin increases the concentration of triacylglycerols in fruit flies.

Monoclonal antibody targeting of N-cadherin inhibits growth.

The tissue surrounding the granuloma in an immune cell induces an anti-inflammatory immune response.

Cancer-associated fibroblasts (CAFs) interact with cancer cells to mediate formation and activation of CAFs.

Increased flux of microbial products provokes immune responses.

Upregulation of dynein in Drosophila neurons increases the number of microtubule plus-ends growing toward the cell body of each neuron.

Incidence of sepsis has fallen substantially from 2009 to 2014.

Increased vessel density along with a reduction in fibrosis improves the efficacy of chemotherapy treatments.

Patients in stable partnerships have a slower progression from HIV to AIDS.

The DESMOND program demonstrates no significant impact on biochemical outcomes.

Approximately 250,000 people are infected with human T-cell lymphotropic virus type 1 in the United Kingdom.

Higher plasma levels of I-carnitine, when associated with trimethylamine N-oxide, are positively correlated with cardiovascular events in humans.

Higher plasma levels of I-carnitine, when associated with trimethylamine N-oxide, are negatively correlated with cardiovascular events in humans.

Oxidative DNA damage activates STING signalling.


Rapid phosphotransfer rates are correlated with histidine kinase regulator specificity.

V-9302 inhibits antitumor responses by decreasing cell death and oxidative stress.

Insulin decreases risk of severe kidney failure.

Cancer-associated fibroblasts (CAFs) are constituents of tumor microenvironments

p75 NTR - associated cell death executor (NADE) interacts with the p75 NTR death domain

Removal of H3K9me3 improves reprogramming efficiency in human somatic cell nuclear transfer experiments.

Diabetes remission occurs less in people treated with conventional therapy than in people treated with laparoscopic adjustable gastric banding surgery.

Forkhead 0 (fox0) transcription factors are involved in apoptosis.

The DEXI promoter region is bound by multiple transcription factors in a murine haematopoietic progenitor cell line.

Pioneer factor OCT3/4 interacts with major chromatin remodeling factors.

Patients with panic anxiety show decreased CSF levels of hypocretin.

Increased lipolysis leads to higher P38 phosphorylation in adipose tissue.

Reduced levels of lipolysis leads to higher P38 phosphorylation in adipose tissue.

Ethanol stress lowers the expression of PSP in bacteria.

Low nucleosome occupancy correlates with high methylation levels across species.

Ethanol stress increases the expression of PSP in bacteria.

H4 G94P proteins induce degradation of free histones via Rad53-dependent mechanisms.

H4 G94P proteins induce chromatin assembly, which increases free histones.

A deficiency of folate increases blood levels of homocysteine.

Oxidative phosphorylation is one of the primary glycometabolic pathways in cells.


Recognition of start codons depends on the translation initiation factor IF3.

Patients with common epithelial cancers  are more likely to have an emergency event as their first hospital admission if they live in resource-deprived areas.

70% of burn patients are admitted for hospitalization and further treatment after appearing at hospital emergency wards or outpatient clinics.

GATA3 regulates self-renewal capacity in bone marrow hematopoietic stem cells.

Chemical injury represses transglutaminase 2 activity.

HOXB4 is a highly expressed component of cellular secretome from fetal liver cell populations.

Radioiodine treatment of non-toxic multinodular goitre increases thyroid volume.

Replacement of histone H2A with H2A.Z accelerates gene activation in yeasts by destabilizing +1 nucleosomes.

Chenodeoxycholic acid treatment decreases brown adipose tissue activity.

Perigenital skin is not the primary site of HIV acquisition.

Formation of N-terminal pyroglutamate by glutamine cyclase (GC) competes with NTAQ1 for Nt-Gln substrates.

mcm 5 s 2 U is required for proper decoding of NNR codons in eukaryotes.

Transcription rates in S. cerevisiae range between 0.7 and 2 kb/min.

Transcription rates in S. cerevisiae range between 7 and 12 kb/min.

IFIT1 speeds viral replication by allowing for the proliferation of mis-capped viral RNAs.

The repeat-variable diresidue (RVD) in the loop of Transcription-Activator Like (TAL) effectors specifies the nucleotides-amino acid contact at the target promoter element.

Cytochrome c is transferred from cytosol to the mitochondrial intermembrane space during apoptosis.

Trans-acting factors, such as lncRNAs, influence mRNA translation.

Most termination events in Okazaki fragments are dictated by initiation patterns.

miRNAs enforce homeostasis by suppressing low-level ''leaky'' transcription.


Reduced levels of lipolysis leads to higher P38 phosphorylation in adipose tissue.

Ethanol stress increases the expression of IBP in bacteria.

Expression of oncolytic virus antigens as peptides makes relapse more likely.

The appearance of brown-like or beige cells primarily occurs in visceral fat, not subcutaneous fat.

Mitochondria play a major role in energy production.

ScPif1p has reduced binding ability to G-rich ssDNA compared to non-G-rich ssDNA.

Klf4 is not required for proper myeloid cell differentiation.

Upregulation of dynein in Drosophila neurons increases the number of microtubule plus-ends growing toward the cell body of each neuron.

Osteocytes have an essential role in G-CSF induced HSPC mobilization.

Drosophila supracellular actomyosin structures are found at boundaries in wing imaginal discs.

One in two surgical randomized controlled trials are discontinued early.

Increased lipolysis leads to higher P38 phosphorylation in adipose tissue.

Inhibiting glucose-6-phospate dehydrogenase improves lipogenesis by deactivating LKB1-AMPK signaling.

AMP-activated protein kinase (AMPK) activation reduces inflammation-related fibrosis in the lungs.

Chenodeoxycholic acid treatment increases brown adipose tissue activity.

APOE4 expression in iPSC-derived neurons results in decreased tau phosphorylation.

Chenodeoxycholic acid treatment decreases brown adipose tissue activity.

The M2-phenotype in brown adipose tissue macrophages increases brown adipose tissue thermogenic activity.

The morphology change from large white adipocytes to small brown adipocytes is a sign of decreased energy expenditure potential in white adipose tissue.

The morphology change from large white adipocytes to small brown adipocytes is a sign of increased energy expenditure potential in white adipose tissue.


Reduced phosphorylation of PP2A increases HDAC4 dephosphorylation by enhancing PP2A-HDAC4 interaction.

Depletion of nitric oxide is responsible for vasospasm.

B3-Galectin increases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR.

Rising temperatures caused by global warming increases risk of dengue fever transmission.

Dscam1 acts as a hypervariable pattern-recognition receptor for the immune system.

NR5A2 is important in reverse cholesterol transport in humans.

Aged patients are less susceptible to ischaemia/reperfusion injury.

Pioglitazone use is significantly associated with an increased risk of pancreatic cancer.

Exposure to fine particulate air pollution is unrelated to anxiety prevalence.

Rotator cuff exercises are more effective than general exercise therapy in reducing pain and improving function of the shoulder.

Reduced phosphorylation of PP2A suppresses HDAC4 dephosphorylation.

p16INK4A degradation is encoded by CDKN2A.

C2 works synergistically with A-769662 to activate dephosphorylated AMPK.

BCL-2 activation antagonizes the apoptotic effects of c-Myc.

BCL-2 promotes the apoptotic effects of c-Myc.

DUSP4 downregulation deactivates the Ras-ERK pathway

Reduced levels of lipolysis leads to higher P38 phosphorylation in adipose tissue.

PCSK9 inhibitors decrease plasma Lp(a) levels.


Reduced phosphorylation of PP2A suppresses HDAC4 dephosphorylation.

A high microerythrocyte count protects against severe anemia in homozygous alpha (+)- thalassemia trait subjects.

miR-142-5P is a known regulator of raised body temperature.

Autophagy deficiency in the liver increases vulnerability to insulin resistance.

Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection increases dissemination of Salmonella Typhimurium from the gut.

Anthrax spores are very difficult to dispose once they are dispersed.

RA activation of DIF2 and NB4 cells induces hallmarks of transcriptionally active promoters.

The proportion of people with visual difficulty is two times higher in low-income countries than in high-income countries.

Side effects associated with antidepressants do not represent a mortality risk to postmenopausal women.

Long chain polyunsaturated fatty acids supplementation reduces wheezing and asthma.

Primary cervical cancer screening with HPV detection has lower longitudinal sensitivity than conventional cytology to detect cervical intraepithelial neoplasia grade 2.

Activation of PPM1D enhances p53 function.


Reduced responsiveness to interleukin-2 in regulatory T cells is associated with autoimmune diseases such as Type 1 Diabetes.

Up-regulation of the p53 pathway and related molecular events speeds cancer progression.

Increased flux of microbial products suppresses immune responses.

Lack of FGF21 in mice increases life expectancy.

Major vault protein regulates sorting of tumor suppressive miR-193a into EVs.

Taking 400mg of α-tocopheryl acetate does not prevent prostate cancer.

Diabetes remission occurs less in people treated with conventional therapy than in people treated with laparoscopic adjustable gastric banding surgery.

Ectopic expression of Sall4, Nanog, Esrrb, and Lin28 generates induced pluripotent stem cells from mouse embryonic fibroblasts more efficiently than other factor combinations.

Chlamydia trachomatis is most prevalent in the UK among sexually-experienced individuals aged 16 to 24.

Omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegans.

Neutrophil extracellular trap (NET) antigens may contain the targeted autoantigens PR3 and MPO.

IL-10 production by monocytes inhibits CD4 + T cell response.

Major antigen-induced signals from the T cell receptor and secondary signals from costimulatory receptors are required for T cell activation.

Type 1 Diabetes is associated with subtle perturbations in T reg development.

CD28 signals regulate trafficking of murine auto-reactive T cells into target tissues.

Foxk2 regulates autophagy genes in muscle cells and fibroblast cells.

Egr2 regulates the homeostasis of B and T cells.

Foxp3 represses the expression of transcriptional regulators implicated in memory T cell development.

Egr3 regulates the homeostasis of B and T cells.

Foxp3 enables the expression of transcriptional regulators implicated in memory T cell development.


Reducing H3k4me3 methylation induces mouse epiblast stem cells to naive pluripotency efficiently.

Tumor development occurs in conjunction with suppression of pro-inflammatory cytokines.

Misunderstandings between doctors and patients can lead to non-adherence.

Fibroblast growth factor 21 protects against atherosclerosis by modulating adiponectin and SREBP2 levels.

TNFAIP3 is a tumor enhancer in glioblastoma.

7-day-old adult Caenorhabditis elegans exhibit approximately 5% of the learning capacity seen in 1-day old adults.

General exercise therapy is more effective than rotator cuff exercises in reducing pain and improving function of the shoulder.

One in two surgical randomized controlled trials are discontinued early.

COPI coatmer is involved in viral replication.

The predominant localization of Linc00173 is in mononuclear macrophage nuclei.

Alteration of origin firing causes changes in termination zones of Okazaki fragments.

Removal of H3K9me3 by ectopic expression of other H3K9 demethylases improves reprogramming efficiency in SCNT experiments.

Removal of H3K9me3 by ectopic expression of other H3K9 demethylases decreases reprogramming efficiency in SCNT experiments.

Removal of H3K9me3 improves reprogramming efficiency in human somatic cell nuclear transfer experiments.

MEK inhibitors are effective treatments in RAS-driven mouse models of cancer.

Reduction of Rpl38 alters the composition of the Hox gene mRNAs translation in mice without lowering overall protein synthesis.

H4 G94P proteins induce degradation of free histones via Rad53-dependent mechanisms.

p16INK4A degradation is encoded by CDKN2A.

H4 G94P proteins suppress degradation of free histones via Rad53-dependent mechanisms.


Reduction of Rpl38 alters the composition of the Hox gene mRNAs translation in mice without lowering overall protein synthesis.

Thiopurine active metabolites can be catabolized through dephosphorylation of thioguanine nucleotides.

Lmna knock-in models are appropriate for testing therapeutic approaches against Hutchinson-Gilford progeria syndrome (HGPS).

Nonhypertensive people who are 55 years old have a 90% chance of developing hypertension during their lifetime.

MafA phosphorylation enhances its ubiquitination.

MICAL redox enzymes regulate actin dynamics in many cell types.

HSCT-T dosage may not be diagnostic if the onset of symptoms occurs less than 3 hours before AMI.

The one-child policy has created a hospitable environment for female infants.

HNF4A mutations are associated with macrosomia in infancy.

DUSP4 downregulation deactivates the Ras-ERK pathway

Reduced levels of lipolysis leads to higher P38 phosphorylation in adipose tissue.

Activation of PPM1D enhances p53 function.

The G34R/V mutation does not create a hypomethylated phenotype at the H3K36 histone.

Increased lipolysis leads to higher P38 phosphorylation in adipose tissue.

The G34R/V mutation creates a hypomethylated phenotype at the H3K36 histone.


Reduction of purity of cytoplasmic membranes isolated from overexpressors is indicated by stronger spots for OmpA in 2D BN-PAGE gels.

Mutations in RIM1 decrease levels of IME1 RNA.

Cnn1 recruitment varies with cell cycle timing.

YAP/TAZ is required in intestinal regeneration in mouse models of ulcerative colitis.

Clathrin stabilizes the spindle fiber apparatus during mitosis.

Folate and vitamin B12 levels influence the association between homocysteine and preeclampsia.

Women are more susceptible to death due to pneumonia when compared to men.

Increased purity of cytoplasmic membranes isolated from overexpressors is indicated by stronger spots for OmpF in 2D BN-PAGE gels.

Induced hepatic stem cells possess the potential to differentiate into hepatocytic cells.

In British Men, haplogroup I increases risk of cardiovascular disease by 50%.

G-CSF increases the expansion and infiltration of MDSCs into tumors.

Reduction of purity of cytoplasmic membranes isolated from overexpressors is indicated by stronger spots for OmpF in 2D BN-PAGE gels.

Lamins have no effect on nuclear membrane structure maintenance.

Intramembrane cleavage by signal peptide peptidase aids in the degradation of proteins with a complex membrane orientation.

The microtubule-dependent delivery and secretion of matrix metalloproteases (MMPs) is partially responsible for the disassembly of adhesion sites.

Many transmembrane receptors transmit signals by long-range conformational changes in the association of alpha-helices across the plasma membrane.

Mice defective for deoxyribonucleic acid (DNA) polymerase m (polm) fail to reveal increased sensitivity to ionizing radiation (IR).

Lamins are associated with nuclear membrane structure maintenance.

Mice defective for deoxyribonucleic acid (DNA) polymerase m (polm) reveal increased sensitivity to ionizing radiation (IR).


Reduction of purity of cytoplasmic membranes isolated from overexpressors is indicated by stronger spots for OmpF in 2D BN-PAGE gels.

Antidepressants reduce the severity of migraines.

Transplanted human glial progenitor cells can mature in their host animal.

Diabetes remission occurs more in people treated with conventional therapy than in people treated with laparoscopic adjustable gastric banding surgery.

The DESMOND program caused substantial weight loss in most participants.

Osteocytes have an essential role in G-CSF induced HSPC mobilization.

Activated Cdk5 phosphorylates the ATM protein in response to DNA damage.

Varying expression levels of EBI2 affect the positioning and migration of B cells.

Incidence of 10/66 dementia is higher than the incidence of DSM-IV dementia.

The relationship between a breast cancer patient's capacity to metabolize tamoxifen and treatment outcome is independent of the patient's genetic make-up.

Mutations in G-Beta protein GNB1 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.

Broadly HIV-1 Neutralizing Antibodies (bnAb) 10EB have no affinity for phospholipids.


Removal of H3K9me3 by ectopic expression of other H3K9 demethylases decreases reprogramming efficiency in SCNT experiments.

Intramembrane cleavage by signal peptide peptidase aids in the degradation of proteins with a complex membrane orientation.

Bariatric surgery leads to positive outcomes in mental health.

The myocardial cell lineage originally develops from cardiac progenitors of exclusively endodermal origin.

Mitochondria play a major role in energy production.

Occipital activation levels are associated with auditory spatial performance in parietal regions of the brain.

Osteoparthritis (OA) is characterized by degeneration of articular cartilage, joint edge, and subchondral bone hyperplasia.

MEK inhibitors are effective treatments in RAS-driven mouse models of cancer.

The proportion of people with visual difficulty is two times higher in low-income countries than in high-income countries.

Patients in stable partnerships progress from HIV to death at the same rate as patients not in partnerships.

Removal of H3K9me3 by ectopic expression of other H3K9 demethylases improves reprogramming efficiency in SCNT experiments.

Removal of H3K9me3 improves reprogramming efficiency in human somatic cell nuclear transfer experiments.

Reducing H3k4me3 methylation induces mouse epiblast stem cells to naive pluripotency efficiently.

H4 G94P proteins induce degradation of free histones via Rad53-dependent mechanisms.

Inhibiting glucose-6-phospate dehydrogenase improves lipogenesis by deactivating LKB1-AMPK signaling.

H4 G94P proteins suppress degradation of free histones via Rad53-dependent mechanisms.

The G34R/V mutation does not create a hypomethylated phenotype at the H3K36 histone.

JMJD6 slows the hydroxylation of C-terminal lysine

The G34R/V mutation creates a hypomethylated phenotype at the H3K36 histone.


Removal of H3K9me3 by ectopic expression of other H3K9 demethylases improves reprogramming efficiency in SCNT experiments.

Female carriers of the Apolipoprotein E4 (APOE4) allele have longer lifetime exposure to estrogen due to an increased reproductive period.

Long chain polyunsaturated fatty acids supplementation reduces wheezing and asthma.

Deletion of ATM and Rad3 related protein is not predictive of acute tissue loss.

Pharmacist attendance at ward rounds increases adverse events in wards.

VgrG (Tssl) protein punctures membranes by forming a spike at the tip of the tube apparatus.

Having a main partner worsens HIV outcomes.

Vitamin D is an important factor in the relationship between calcium and parathyroid hormone.

Origin gross domestic product(GDP) is positively related to dengue virus (DENV-1) diffusion in air traffic shipments.

Long - range chromatin interactions regulate transcription.

F4/80+ macrophages regulate mature osteoblast maintenance.

C2 works synergistically with A-769662 to activate dephosphorylated AMPK.


Removal of H3K9me3 improves reprogramming efficiency in human somatic cell nuclear transfer experiments.

Lack of FGF21 in mice slows the rate of atherosclerotic plaque formation.

PGE 2 suppresss intestinal tumor growth by altering the expression of tumor suppressing and DNA repair genes.

The predominant localization of Linc00173 is in mononuclear macrophage nuclei.

The DESMOND program demonstrates no significant impact on biochemical outcomes.

Ribosome-inactivating protein-2 (RIP-2) interacts with the p75 NTR death domain

COPI coatmer is involved in viral replication.

CCL19 is predominantly present within dLNs.

Stiff substrates inhibit mesodermal differentiation by degrading beta-catenin in an integrin-dependent manner.

PTEN is a regulator for the transcriptional activity of SRF

Activation of PPM1D enhances p53 function.

Cytochrome c is transferred from cytosol to the mitochondrial intermembrane space during apoptosis.

Activated Cdk5 regulates DNA damage-induced neuronal death.

Replacement of histone H2A with H2A.Z accelerates gene activation in yeasts by destabilizing +1 nucleosomes.


Replacement of OCT4 and SOX2 genes with GATA3 has the ability to reprogram human cells.

Mitochondria play a major role in apoptosis.

Mice lacking Sirt1 in Sf1-expressing neurons have increased susceptibility to diet-induced obesity and insulin resistance.

Tumor development occurs in conjunction with suppression of pro-inflammatory cytokines.

The PRDM1 gene is a key determinant of primordial germ cells.

GATA3 regulates cell cycle progression in bone marrow hematopoietic stem cells.

Pseudoknots are not evolutionarily conserved in most eukaryotes.

Decreased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm.

The most prevalent adverse events to Semaglutide are cardiovascular.

Tuberculosis-induced granulomas express different immune system protein signatures than the surrounding tissue.

Pharmacist attendance at ward rounds increases adverse events in wards.

Replacement of OCT4 and SOX2 genes with GATA3 is not capable of reprogramming human cells.

In transgenic mice harboring green florescent protein under the control of the Sox2 promoter, more than 50 percent of the cells with green florescent colocalize with cell proliferation markers.

ATM and Rad3 related protein have no role in sensing DNA damage.

ATM and Rad3 related protein are critical for sensing DNA damage.

Pioneer factor OCT3/4 interacts with major chromatin remodeling factors.

There is no known interaction between Pioneer factor OCT3/4 and major chromatin remodeling factors.

CD28 signals regulate trafficking of murine auto-reactive T cells into target tissues.

Activated Cdk5 phosphorylates the ATM protein in response to DNA damage.

HIV trans-activator protein (TAT) effectively transports large and small molecules across cellular membranes into larger populations of neurons.


Replacement of OCT4 and SOX2 genes with GATA3 is not capable of reprogramming human cells.

R2D2 stops miRNA production by increasing the selectivity of Dcr2 for long dsRNA.

Ethanol stress increases the expression of PSP in bacteria.

The minor G allele of FOXO3 up-regulates IL-10.

Nonhuman primates are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.

7-day-old adult Caenorhabditis elegans exhibit approximately 75% of the learning capacity seen in 1-day old adults.

MafA ubiquitination increases the recruitment of coavtivator P/CAF by MafA.

Primary pro-inflammatory cytokines suppress secondary pro- and anti-inflammatory mediators.

Pyridostatin stabilizes the G - quadruplex in the telomeric region.

De novo assembly of sequence data has shorter contigs than unassembled sequence data.

Adult tissue-resident macrophages are seeded before birth.

Gpr124 suppresses BBB breakdown in mouse models of ischemic stroke.

Deletion of ATM and Rad3 related protein is not predictive of acute tissue loss.

Deletion of ATM and Rad3 related protein leads to acute tissue loss.

In a naive state, blocking Wingless-Int-1 secretion from mouse embryonic stem cells inhibits self-renewal of the mouse embryonic stem cells.


Replacement of histone H2A with H2A.Z accelerates gene activation in yeasts by destabilizing +1 nucleosomes.

Glycan adaptation is rarely observed in the B-cell repertoire.

Students who perform poorly in the early years of medical school are less likely to commit professional misconduct later in their careers.

Patients in stable partnerships have a slower progression from HIV to AIDS.

Angiotensin converting enzyme inhibitors are associated with decreased risk for functional renal insufficiency.

Formation of N-terminal pyroglutamate by glutamine cyclase (GC) competes with NTAQ1 for Nt-Gln substrates.

Immune complex triggered cell death leads to sequestration of oxidized mitochondrial DNA.

CD28 signals regulate trafficking of murine auto-reactive T cells into target tissues.

KRT17 modulates the expression of the transcriptional regulator AIRE in diseased epithelia.

Cardiac tissue-resident macrophages directly contribute to electrical activity.

Pre-mRNAs associated with spliceosomal components are more stable than unassociated splicing substrates.

H4 G94P proteins induce degradation of free histones via Rad53-dependent mechanisms.

H4 G94P proteins induce chromatin assembly, which increases free histones.

H4 G94P proteins suppress degradation of free histones via Rad53-dependent mechanisms.

H4 G94P proteins inhibit chromatin assembly, which decreases free histones.

The H2A-H2B eviction defect is compensated for by other histone chaperone(s).

FACT and other histone chaperone(s) compensate for Histone 2A (H2A)-histone 2B (H2B) dimer eviction during the histone exchange process.

The Snf1 complex regulates carbon and energy metabolism in baker's yeast (Saccharomyces cerevisiae).

The deamination of cytidine to uridine on the minus strand of viral DNA can inactivate the viral genome by inducing G-to-A mutations.


Repressing IL-18 has negative effects on atherosclerotic lesion composition and progression.

CCL19 is predominantly present within dLNs.

The morphology change from large white adipocytes to small brown adipocytes is a sign of increased energy expenditure potential in white adipose tissue.

H4 G94P proteins suppress degradation of free histones via Rad53-dependent mechanisms.

Fibroblast Growth Factor is a ligand which signals through receptor tyrosine kinases.

Cyclin A2 destruction is necessary to switch from unstable to stable kt-mt attachments in mitosis.

Major vault protein (MVP) leads to more aggressive tumors by regulating the sorting of tumor suppressive miR-193a into extracellular vesicles (EVs).

Patients with common epithelial cancers  are more likely to have an emergency event as their first hospital admission if they live in resource-deprived areas.

Varenicline monotherapy is more effective after 26 weeks of treatment compared to combination nicotine replacement therapies with varenicline or bupropion.

Gastric infection with Helicobacter pylori increases risk of gastric cancer in humans.

Interleukin-18 plays an important role in the pathogenesis of atherosclerosis.

IL-6 signaling plays a major role in atherosclerotic cardiovascular disease.

PD-1 triggering on monocytes enhances IL-10 production by monocytes.

p16INK4A degradation is  linked to an abnormal wound response caused by the microinvasive step of advanced Oral Potentially Malignant Lesions (OPMLs).

Neutrophils produce IL-1β in response to large particles.

Certain immunomodulator-human dialyzable leukocyte extract (hDLE) peptides are recognized by toll-like receptors (TLRs) on macrophages and dendritic cells.

IL-10 production by monocytes inhibits CD4 + T cell response.

Monoclonal antibody targeting of N-cadherin encourages metastasis.

The minor G allele of FOXO3 up-regulates IL-10.


Retinoic acid receptor-related orphan receptor gamma (RORγ) is a therapeutic target for castration-resistant prostate cancer (CRPC)

The tissue surrounding the granuloma in an immune cell induces an anti-inflammatory immune response.

Long - range chromatin interactions regulate transcription.

CD28 initiates tonic signaling in conventional T cells, which causes an exhaustion phenotype and limited efficiency.

Less than 10% of patients exposed to radiation have activated markers of mesenchymal stem cells.

The combination of physical examinations with C-reactive protein values do not improve the accuracy of radiographic verified pneumonia predictions.

In chronic viral infections or tumors, peptides that selectively inhibit PTPRS can be utilized to boost insufficient activity of pDCs.

High levels of CRP lead to a higher risk of exacerbations in chronic obstructive pulmonary disease (COPD).

Clathrin stabilizes the spindle fiber apparatus during mitosis.

Gastric infection with Helicobacter pylori decreases risk of gastric cancer in humans.

Natriuretic peptides increase susceptibility to diabetes.

TNFAIP3 is a glioblastoma tumor suppressor.

TNFAIP3 is a glioblastoma tumor enhancer.

TNFAIP3 is a tumor enhancer in glioblastoma.

Cancers that initially benefit from epidermal growth factor receptor targeted therapies later become refractory through several mechanisms.

The NF-κB essential modulator gene prevents intestinal inflammation by inhibiting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death.

LSD1-positive promoters are associated with RNA polymerase II

The NF-κB essential modulator gene induces intestinal inflammation by promoting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death.

Pioglitazone use is not associated with an increased risk of prostate cancer.

Cancer-associated fibroblasts (CAFs) have no known interaction with cancer cells in the formation and activation of CAFs.


Rhythmic expression of Cry1 translates directly into a circadian regulation of cAMP signaling in gluconeogenesis.

Mice are incapable of producing neutralizing antibodies in reponse to the Chikungunya virus (CHIKV) produced in mosquitos.

Nuclear transfer from adult human fibroblasts to human oocytes can give rise to blastocysts containing expandable pluripotent cells.

Notch signaling occurs between tumor cells and stromal cells.

Rhythmic expression of Cry1 translates directly into a circadian regulation of cAMP signaling in hepatic glucose metabolism.

The DESMOND program demonstrates no significant impact on biochemical outcomes.

ScPif1p has reduced binding ability to G-rich ssDNA compared to non-G-rich ssDNA.

In rhesus macaques, daily subcutaneous injections of emtricitabine are ineffective at protecting against rectally transmitted simian-human immunodeficiency virus.

Chlamydia trachomatis is most prevalent in the UK among individuals in their 50s and 60s.

Increased lipolysis leads to higher P38 phosphorylation in adipose tissue.

Binding of p53 to enhancer regions (p53BERs) regulates the activity of p53 transcription and cell cycle arrest through the production of p53-dependent eRNAs.

Activation of PPM1D enhances p53 function.

PKG-la does not have a large impact on expression of pain hypersensitivity in PGK-la knockout mice.

Hypothalamic glutamate neurotransmission is unrelated to energy balance.

Reduced levels of lipolysis leads to higher P38 phosphorylation in adipose tissue.

Energy balance requires hypothalamic glutamate neurotransmission.

Oxidative phosphorylation is one of the primary glycometabolic pathways in cells.


Rhythmic expression of Cry1 translates directly into a circadian regulation of cAMP signaling in hepatic glucose metabolism.

siRNA knockdown of A20 slows tumor progression in an in vivo murine xenograft model.

PKG-la does not have a large impact on expression of spinal long term potentiation in PGK-la knockout mice.

Tuberculosis incidence occurs at higher rates in more sparsely populated areas in the UK.

Formation of N-terminal pyroglutamate by glutamine cyclase (GC) competes with NTAQ1 for Nt-Gln substrates.

A deficiency of vitamin B6 decreases blood levels of homocysteine.

In rhesus macaques, daily subcutaneous injections of tenofovir protects against rectally transmitted simian-human immunodeficiency virus.

Urbanization is an important risk factor related to the transmission of dengue fever.

Destination container port throughput(CPT) is negatively related to dengue virus (DENV-1) diffusion in air traffic shipments.

Differentiation of progenitor cells to myeloid cells is skewed when insulin signaling is suppressed.

The Snf1 complex regulates carbon and energy metabolism in baker's yeast (Saccharomyces cerevisiae).

Ethanol stress increases the expression of PSP in bacteria.

Ethanol stress lowers the expression of PSP in bacteria.


Ribosomal protein (RP) expression is controlled in part by stress-activated regulators.

N348I mutations reduce resistance to nevirapine.

In melanoma, anti-CTLA-4 treatment reinvigorates exhausted PD-1+Eomes+CD8 T cells.

Osteocytes have an essential role in G-CSF induced HSPC mobilization.

Ribosome-inactivating protein-2 (RIP-2) interacts with the p75 NTR death domain

Commelina yellow mottle virus (ComYMV) has three typical badnavirus ORFs, capable of encoding proteins 23, 15, and 216 kD.

The generation of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells.

RAD52 is involved in break-induced DNA replication (BIR).

H.pylori-mediated gastric cancer occurs due to the accumulation of mutations in host epithelial cells.

Increased conversion of PGE 2 to PPARy ligand 15-ket-PGE 2 causes accumulation of PGE.

BiP is a general endoplasmic reticulum stress marker.

miRNAs regulate a unique suite of mRNAs to maintain homeostasis in cells.

ATF4 is a general endoplasmic reticulum stress marker.

Lack of FGF21 in mice increases life expectancy.

Lack of FGF21 in mice leads to reduced lifespan.

Rhythmic expression of Cry1 translates directly into a circadian regulation of cAMP signaling in gluconeogenesis.

Ethanol stress increases the expression of SRL in bacteria.

Mice lacking Sirt1 in Sf1-expressing neurons are immune to diet-induced obesity and insulin resistance.

CD28 signals regulate trafficking of murine auto-reactive T cells into target tissues.


Ribosome-inactivating protein-2 (RIP-2) interacts with the p75 NTR death domain

Taking 400mg of α-tocopheryl acetate does not prevent prostate cancer.

40mg/day dosage of folic acid and 2mg/day dosage of vitamin B12 does not affect chronic kidney disease (CKD) progression.

Low expression of miR7a does not repress target genes or exert a biological function in ovaries.

Prescribed exercise training improves quality of life.

50% of patients exposed to radiation have activated markers of mesenchymal stem cells.

Chlamydia trachomatis is most prevalent in the UK among sexually-experienced individuals aged 16 to 24.

BCL-2 promotes the apoptotic effects of c-Myc.

In S. cerevisiae, the absence of RNA surveillance pathways reduces sensitivity to high iron conditions.

HNF4A mutations are associated with macrosomia in infancy.

Propriospinal interneurons that play a role in the plastic reorganization of spinal circuits are integral for recovery from spinal cord injury.

p75 NTR - associated cell death executor (NADE) interacts with the p75 NTR death domain

Guanine nucleotide dissociation inhibitor (Rho-GDI) interacts with the p75 NTR death domain

Formation of N-terminal pyroglutamate by glutamine cyclase (GC) competes with NTAQ1 for Nt-Gln substrates.

The NF-κB essential modulator gene induces intestinal inflammation by promoting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death.

The NF-κB essential modulator gene prevents intestinal inflammation by inhibiting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death.

MUC1-C activates the NF-κB p65 signaling pathway by interacting with IκB kinase ß.

Smc5/6 engagment halts the activation of SUMO E3 ligase Mms21 by ATP-dependent remolding.

RAD52 is involved in break-induced DNA replication (BIR).


Ribosomopathies have a high degree of cell and tissue specific pathology.

Aggravated inflammation is dependent on NLRP3 inflammasome activation.

4-PBA treatment raises endoplasmic reticulum stress in response to general endoplasmic reticulum stress markers.

Taxation of sugar-sweetened beverages reduced the incidence rate of type II diabetes in India.

Perigenital skin is not the primary site of HIV acquisition.

Citrullinated proteins externalized in neutrophil extracellular traps act indirectly to perpetuate the inflammatory cycle via induction of autoantibodies.

The ability of activator E2Fs in preventing cell death is limited to terminally differentiated cells.

Antidepressants increase the severity of migraines.

Cytosolic proteins bind to iron-responsive elements on mRNAs coding for TFRC1.

miRNAs regulate a unique suite of mRNAs to maintain homeostasis in cells.

Ribosome-inactivating protein-2 (RIP-2) interacts with the p75 NTR death domain

r-protein chaperones are found in complexes with their r-protein binding partners.

Lamins are found within the inner layer of the mitochondrial membrane of all cells.

Pseudoknots are not evolutionarily conserved in most eukaryotes.

Pre-mRNAs associated with spliceosomal components are less stable than unassociated splicing substrates.

Pre-mRNAs associated with spliceosomal components are more stable than unassociated splicing substrates.

Cancer-associated fibroblasts (CAFs) are constituents of tumor microenvironments

Glioblastoma multiforme (GBM) is characterized by extensive invasion, rapid growth, necrosis, and angiogenesis.

Adult tissue-resident macrophages possess a self-renewing capacity.

The latent infection of myeloid cells with human cytomegalovirus induces a number of changes in gene expression.


Risedronate increases risk of vertebral and non-vertebral fractures.

COPI coatmer is involved in lipid homeostasis.

KRT17 modulates the expression of the transcriptional regulator AIRE in diseased epithelia.

Incidence of 10/66 dementia is higher than the incidence of DSM-IV dementia.

Activation of PPM1D enhances p53 function.

IgA plasma cells that are specific for transglutaminase 2 are scarce in the duodenal mucosa of celiac disease patients when the disease is active.

Surgical treatment is not superior to non-surgical in treating adults with displaced fractures of the proximal humerus.

Deltex has no known interactions with eIF3f.

CD28 signals regulate trafficking of murine auto-reactive T cells into target tissues.

MafA ubiquitination decreases the recruitment of coavtivator P/CAF by MafA.

Osteoparthritis (OA) is characterized by degeneration of articular cartilage, joint edge, and subchondral bone hyperplasia.

Dexamethasone increases risk of postoperative bleeding.

There is a positive correlation between hip fractures and statin use.

There is no increased risk of hypospadias with clomiphene.

The peak incidence of fractures occurs in toddlers.

The peak incidence of fractures occurs during pubertal growth spurt in early adolescents.

Sildenafil worsens erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.

Radioiodine treatment of non-toxic multinodular goitre increases thyroid volume.


Rising temperatures caused by global warming increases risk of dengue fever transmission.

In melanoma, anti-CTLA-4 treatment reinvigorates exhausted PD-1+Eomes+CD8 T cells.

Ectopic expression of Sall4, Nanog, Esrrb, and Lin28 generates induced pluripotent stem cells from mouse embryonic fibroblasts more efficiently than other factor combinations.

L3MBTL2 binds to H2AK119Ub marked chromatin to form a PRC1 complex.

ART substantially reduces infectiveness of HIV-positive people.

7-day-old adult Caenorhabditis elegans exhibit approximately 75% of the learning capacity seen in 1-day old adults.

Chinese individuals with TT homozygosity in the MTHFR gene are less vulnerable to strokes caused by low levels of folate intake.

ITAM phosphorylation allows for the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).

Lipopolysaccharides have an inflammation independent effect on kidney barrier function.

The most prevalent adverse events to Semaglutide are gastrointestinal.

Rising temperatures caused by global warming lowers the risk of dengue fever transmission.

Urbanization is an important risk factor related to the transmission of dengue fever.

There was an estimated 30 million cases of pneumonia in young children worldwide in 2010.

Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission.

The World Health Organization's (WHO) data collection process is biased downward by unequal selection of larger outbreaks.

Eilat virus (EILV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in nonhuman primates.

The latent infection of myeloid cells with human cytomegalovirus induces a number of changes in gene expression.

Mice are incapable of producing neutralizing antibodies in reponse to the Chikungunya virus (CHIKV) produced in mosquitos.


Rising temperatures caused by global warming lowers the risk of dengue fever transmission.

Chenodeoxycholic acid treatment decreases brown adipose tissue activity.

Stroke patients with prior use of direct oral anticoagulants have a higher risk of in-hospital mortality than stroke patients with prior use of warfarin.

Peroxynitrite is required for induction of T cell tolerance.

Removal of H3K9me3 by ectopic expression of other H3K9 demethylases decreases reprogramming efficiency in SCNT experiments.

Nonhuman primates are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.

Adult tissue-resident macrophages stem from the embryonal yolk sac and fetal liver.

Increased microtubule acetylation worsens interference of axonal transport caused by LRRK2 Roc-COR domain mutations.

Bacterial meningitis can be diagnosed on the basis of positive cerebrospinal fluid (CSF) cultures.

HNF4A mutations are associated with macrosomia in infancy.

TRAP+ osteoclasts regulate mature osteoblast maintenance.

Eliminating the last sporadic cases of malaria requires considerable funding.


Risk of cardiovascular events can be cut by a third by using antihypertensive drug therapy among hemodialysis patients.

Environmentally-induced senescence is mimicked in disease modeling by adding specific molecules to the culture system.

Metastatic colorectal cancer treated with a single agent fluoropyrimidines resulted in similar efficacy and better quality of life when compared with oxaliplatin-based chemotherapy in elderly patients.

H4 G94P proteins induce chromatin assembly, which increases free histones.

The DESMOND program demonstrates no significant impact on lifestyles outcomes.

Osteocytes have an essential role in G-CSF induced HSPC mobilization.

Oat tolerant coeliac patients may have oat specific inflammatory cells in their small bowel mucosa.

Helicobacter pylori-induced aberrant NF-kB-dependent expression of activation-induced cytidine deaminase contributes to the mutagenesis of host DNA.

0-dimensional biomaterials lack inductive properties.

10% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.

In young and middle-aged adults, current or remote uses of ADHD medications increase the risk of serious cardiovascular events.

Diabetic patients with acute coronary syndrome experience decreased short-term and long-term risk for bleeding events.

Systemic lupus erythematosus is a risk factor for cardiovascular disease.

CRP is positively correlated with postoperative mortality following Coronary Artery Bypass Graft (CABG) surgery.

Sudden death can occur in patients with orthostatic hypertension without cardiac conduction abnormalities.

Insulin decreases risk of severe kidney failure.

Including pharmacists in rounding teams does not alter the incidence of adverse drug events (ADEs).

Side effects associated with antidepressants increases risk of stroke.

Side effects associated with antidepressants lower risk of myocardial infarction.


Risk-adjusted mortality rates are similar in teaching and non-teaching hospitals.

Activator-inhibitor pairs are provided ventrally by Xrl-sizzled.

The G34R/V mutation creates a hypomethylated phenotype at the H3K36 histone.

MafA phosphorylation decreases its ubiquitination.

Incidence of sepsis has fallen substantially from 2009 to 2014.

Natriuretic peptides protect against diabetes.

Weighed food records (WFR) result in poor completion since they're costly to run and impose high participant burden.

Genetic deletion of JAM-A increases gut permeability.

Reduction of purity of cytoplasmic membranes isolated from overexpressors is indicated by stronger spots for OmpF in 2D BN-PAGE gels.

Sepsis related mortality has risen from 2009 to 2014.

Cost effectiveness evaluations based on cRCT data accurately reflect prices for patients in actual clinical practice.

Sepsis related mortality has remained stable between 2009-2014.

Students who perform poorly in the early years of medical school are less likely to commit professional misconduct later in their careers.

The mean suicide rate in women is lower after miscarriage than live birth.

The mean suicide rate in women is higher after miscarriage than live birth.

Assessing treatment adherence is more beneficial to clinical practice than measuring routine outcomes.

Tuberculosis incidence occurs at higher rates in more sparsely populated areas in the UK.

Students who perform poorly in the early years of medical school are at increased risk for professional misconduct later in their careers.


Rotator cuff exercises are more effective than general exercise therapy in reducing pain and improving function of the shoulder.

Notch signaling occurs between tumor cells and stromal cells.

Cancers that initially benefit from epidermal growth factor receptor targeted therapies later become refractory through several mechanisms.

The gene daf-16, which encodes forkhead Box O (FOXO), is required for all phenotypes associated with reduced insulin/insulin-like growth factor (Igf) signaling.

The ability of activator E2Fs in preventing cell death is limited to terminally differentiated cells.

Mice lacking Sirt1 in Sf1-expressing neurons are immune to diet-induced obesity and insulin resistance.

Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 encourage West Nile virus replication in cortical neurons.

Pharmacist attendance at ward rounds reduces adverse events in wards.

Formation of N-terminal pyroglutamate by glutamine cyclase (GC) competes with NTAQ1 for Nt-Gln substrates.

The artifactual C-terminal helix swapping in the StART domain is observed in the Ups1-Mdm35 heterodimer of the StARkin superfamily.

General exercise therapy is more effective than rotator cuff exercises in reducing pain and improving function of the shoulder.

Scapular stabilizer exercises are more effective than general exercise therapy in reducing pain and improving function of the shoulder.

General exercise therapy is more effective than scapular stabilizer exercises in reducing pain and improving function of the shoulder.

Surgical treatment is not superior to non-surgical in treating adults with displaced fractures of the proximal humerus.

Roughly 55% of women with chronic pelvic pain have no underlying pathology.

There is a positive correlation between hip fractures and statin use.

Osteoparthritis (OA) is characterized by degeneration of articular cartilage, joint edge, and subchondral bone hyperplasia.

Bariatric surgery leads to negative outcomes in mental health.

Propriospinal interneurons that play a role in the plastic reorganization of spinal circuits are integral for recovery from spinal cord injury.


Roughly 55% of women with chronic pelvic pain have no underlying pathology.

Egr3 regulates the homeostasis of B and T cells.

FACT and other histone chaperone(s) compensate for Histone 2A (H2A)-histone 2B (H2B) dimer eviction during the histone exchange process.

Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission.

Amitriptyline is an effective treatment for chronic tension-type headaches.

Androgenetic haploid mouse embryonic stem cells (ESCs) can be derived and genetically manipulated in vitro.

Low expression of miR7a does not repress target genes or exert a biological function in testis.

The one-child policy has created a hospitable environment for female infants.

The C-type lectin receptor (CLEC-2) rearranges the actin cytoskeleton in dendritic cells to promote efficient motility along stromal surfaces.

The US health care system can save up to $5 billion if 7% of patients waiting for kidney transplants participate in the optimized national kidney paired donation program.

The peak incidence of fractures occurs in toddlers.

Bacterial meningitis can be diagnosed on the basis of positive cerebrospinal fluid (CSF) cultures.


Satellite cell dysfunction is a key factor in sarcopenia development.

Nonsteroidal antinflammatory drugs are ineffective as cancer treatments.

Moderate consumption of candy and chocolate reduces the risk of cardiovascular disease (CVD).

Transcription rates in S. cerevisiae range between 7 and 12 kb/min.

53% of perinatal mortality is due to low birth weight.

Cellular clocks are not predictive of mitosis timing in NIH 3T3 cells.

Female carriers of the Apolipoprotein E4 (APOE4) allele have increased risk for Alzheimer's disease.

Pediatric SCD patients with vaso-occlusive crisis show increased morphine use after breathing 80 ppm iNO for 4 hours.

The RANK-RANK-Ligand (RANKL) pathway is involved in the development of Aire-expressing medullary thymic epithelial cells (mTECs).

Ultrasound guidance significantly reduces the number of traumatic procedures when attempting needle insertion.

Pioglitazone use is not associated with an increased risk of prostate cancer.

The cytokine receptor which regulates chemotaxis and formation of lymph nodes is involved in production of myeloperoxidase in the left atrium.

Differentiation of progenitor cells to myeloid cells is skewed upon activation of insulin signaling.

Differentiation of progenitor cells to myeloid cells is skewed when insulin signaling is suppressed.

The proliferative capacity of neural progenitors differs across species.

The proliferative capacity of progenitors is regulated cell-autonomously.

Cancer cells can stimulate the accumulation of intra-tumoural myeloid-derived suppressor cells by promoting granulocyte colony stimulating factor production.

Klf4 is important for proper myeloid cell differentiation.


ScPif1p has higher binding ability to G-rich ssDNA than to non-G-rich ssDNA.

There is a positive correlation between hip fractures and statin use.

Tonic signaling from the scFv induces constitutive stimulation.

At least 85% of patients exposed to radiation have activated markers of myofibroblasts.

Primary cervical cytology screening with HPV detection has higher longitudinal sensitivity to detect severe cervical intraepithelial neoplasia than conventional cytology.

Participants who quit smoking reduce lung cancer risk by approximately 50%.

PD-1 triggering on monocytes enhances IL-10 production by monocytes.

Active caspase-11 participate in regulating phagosome-lysosome fusion.

H4 G94P proteins induce chromatin assembly, which increases free histones.

Increased mobility of retrotransposons is assosciated with mutation and higher tumorigenesis rates.

ScPif1p has reduced binding ability to G-rich ssDNA compared to non-G-rich ssDNA.

Mutations in G-Beta protein GNB1 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.

The deamination of cytidine to uridine on the minus strand of viral DNA can inactivate the viral genome by inducing G-to-A mutations.

Deltex has no known interactions with eIF3f.

The G34R/V mutation does not create a hypomethylated phenotype at the H3K36 histone.

The PPR MDA5 has twenty N-terminal CARD domains.

Pyridostatin stabilizes the G - quadruplex in the telomeric region.

The G34R/V mutation creates a hypomethylated phenotype at the H3K36 histone.


ScPif1p has reduced binding ability to G-rich ssDNA compared to non-G-rich ssDNA.

Migraine with aura is associated with ischemic stroke.

Incidence of 10/66 dementia is higher than the incidence of DSM-IV dementia.

Amitriptyline is an effective treatment for chronic tension-type headaches.

HOXB4 facilitates HSC expansion when co-cultured with HSCs.

Consumption of whole fruits increases the risk of type 2 diabetes.

Lice attenuated SIV vaccines induce a stronger antigen-specific T cell response in lymph node cells.

Anthrax spores remain deadly until affected areas are decontaminated.

A deficiency of vitamin B6 decreases blood levels of homocysteine.

Binding of p53 to enhancer regions (p53BERs) regulates the activity of p53 transcription and cell cycle arrest through the production of p53-dependent eRNAs.

Notch signaling occurs between tumor cells and stromal cells.


Scapular stabilizer exercises are more effective than general exercise therapy in reducing pain and improving function of the shoulder.

Walking in traffic areas in London did not improve lung function in elderly adults.

76-85% of people with severe mental disorder receive no treatment in low and middle income countries.

Immune responses in immune cells are geographically segregated.

Nonhypertensive people who are 55 years old have a 90% chance of developing hypertension during their lifetime.

p16INK4A degradation is  linked to an abnormal wound response caused by the microinvasive step of advanced Oral Potentially Malignant Lesions (OPMLs).

Upregulation of PD1 causes the downmodulation of Satb1.

Induced hepatic stem cells possess the potential to differentiate into cholangiocytic cells.

Propriospinal interneurons that play a role in the plastic reorganization of spinal circuits are integral for recovery from spinal cord injury.

The morphology change from large white adipocytes to small brown adipocytes is a sign of decreased energy expenditure potential in white adipose tissue.

Less than 10% of patients exposed to radiation have activated markers of mesenchymal stem cells.

General exercise therapy is more effective than scapular stabilizer exercises in reducing pain and improving function of the shoulder.

Rotator cuff exercises are more effective than general exercise therapy in reducing pain and improving function of the shoulder.

General exercise therapy is more effective than rotator cuff exercises in reducing pain and improving function of the shoulder.

Surgical treatment is not superior to non-surgical in treating adults with displaced fractures of the proximal humerus.

There is a positive correlation between hip fractures and statin use.

Amitriptyline is an effective treatment for chronic tension-type headaches.

Roughly 55% of women with chronic pelvic pain have no underlying pathology.

Bariatric surgery leads to positive outcomes in mental health.

Antidepressants reduce the severity of migraines.


Self-advocacy training is effective at decreasing homelessness.

A mutation in HNF4A leads to an increased risk of diabetes by the age of 14 years.

Helminths interfere with immune system control of coinfections by microbial pathogens 16.

At least 85% of patients exposed to radiation have activated markers of myofibroblasts.

Cognitive behavioral therapy is an ineffective treatment for insomnia

Weighed food records (WFR) result in poor completion since they're costly to run and impose high participant burden.

Ly49Q directs the organization of neutrophil polarization by regulating membrane raft functions.

Guanine nucleotide dissociation inhibitor (Rho-GDI) interacts with the p75 NTR death domain

Origin gross domestic product(GDP) is positively related to dengue virus (DENV-1) diffusion in air traffic shipments.

Activator-inhibitor pairs are provided ventrally by Xrl-sizzled.

A country's Vaccine Alliance (GAVI) eligibility is not indictivate of accelerated adoption of the Hub vaccine.

Input from  mental and physical health care professionals is not effective at decreasing homelessness.

Integrated care is successful at tackling multiple comorbidities.

Integrated care is ineffective at tackling multiple comorbidities.

Having a main partner improves HIV outcomes.

Assessing treatment adherence is more beneficial to clinical practice than measuring routine outcomes.

Measuring routine outcomes is more beneficial to clinical practice than assessing treatment adherence.

Integrating classroom-based collaborative learning with Web-based collaborative learning offers the best class performance.


Sepsis related mortality has remained stable between 2009-2014.

Major vault protein regulates sorting of tumor suppressive miR-193a into EVs.

The US health care system can save up to $5 billion if 7% of patients waiting for kidney transplants participate in the optimized national kidney paired donation program.

Cost effectiveness evaluations based on cRCT data lack external validity.

Deltex has no known interactions with eIF3f.

Chenodeoxycholic acid treatment decreases brown adipose tissue activity.

Including pharmacists in rounding teams reduces the incidence of adverse drug events (ADEs).

Pediatric SCD patients with vaso-occlusive crisis show increased morphine use after breathing 80 ppm iNO for 4 hours.

In melanoma, anti-CTLA-4 treatment reinvigorates exhausted PD-1+Eomes+CD8 T cells.

The PRDM1 gene, when combined with the PRDM14 gene, plays an important role during primordial germ cell specification.

Increase of p62 in prostate tumor stroma results in defective autophagy.

Sepsis related mortality has risen from 2009 to 2014.

Incidence of sepsis has fallen substantially from 2009 to 2014.

10% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.

90% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.

The mean suicide rate in women is higher after miscarriage than live birth.

The mean suicide rate in women is lower after miscarriage than live birth.

53% of perinatal mortality is due to low birth weight.

Risk-adjusted mortality rates are similar in teaching and non-teaching hospitals.

Tuberculosis incidence occurs at higher rates in more sparsely populated areas in the UK.


Sepsis related mortality has risen from 2009 to 2014.

Helminths interfere with immune system control of coinfections by microbial pathogens 16.

The DESMOND program caused substantial weight loss in most participants.

Low expression of miR7a does not repress target genes or exert a biological function in testis.

The proliferative capacity of neural progenitors differs across species.

CHOP is a general endoplasmic reticulum stress marker.

The DESMOND program demonstrates no significant impact on biochemical outcomes.

N348I mutations reduce resistance to nevirapine.

A deficiency of vitamin B6 decreases blood levels of homocysteine.

Diabetes remission occurs less in people treated with conventional therapy than in people treated with laparoscopic adjustable gastric banding surgery.

There was an estimated 30 million cases of pneumonia in young children worldwide in 2010.


Sequence conservation in gene regulatory regions between species is a high-accuracy predictor of conserved functionality.

ITAM phosphorylation allows for the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).

Tonic signaling from the scFv is amplified by MyD88/CD40.

Stroke patients with prior use of direct oral anticoagulants have a higher risk of in-hospital mortality than stroke patients with prior use of warfarin.

MEK inhibitors are effective treatments in RAS-driven mouse models of cancer.

The appearance of brown-like or beige cells primarily occurs in visceral fat, not subcutaneous fat.

Addition of BMP4, activin A, CHIR99021, and SU504 to reprogramming fibroblasts generates, expands and maintains cardiovascular progenitor cells (CPCs)

Post-transcriptional handling of mitochondrial transcripts occurs in mitochondrial RNA granules.

The first MBT repeat of the four malignant brain tumor (4MBT) domain of Drosophila's Sfmbt and of the orthologous mammalian L3MBTL2 is required for the interaction with the spacer region of Drosophila's Pleiohomeotic (Pho) or its human ortholog YY1.

Inhibiting glucose-6-phospate dehydrogenase improves lipogenesis by deactivating LKB1-AMPK signaling.

4-PBA treatment raises endoplasmic reticulum stress in response to general endoplasmic reticulum stress markers.

Sequence conservation in gene regulatory regions between species is a poor predictor of conserved functionality.

Low nucleosome occupancy correlates with high methylation levels across species.

Long - range chromatin interactions regulate transcription.

Genes involved in pre-mRNA splicing have a significant impact on genome stability.

r-protein chaperones are found in complexes with their r-protein binding partners.

Distant CREs are less conserved among species.

The repeat-variable diresidue (RVD) in the loop of Transcription-Activator Like (TAL) effectors specifies the nucleotides-amino acid contact at the target promoter element.

mcm 5 s 2 U is required for proper decoding of NNR codons in eukaryotes.

Pseudoknots are not evolutionarily conserved in most eukaryotes.


Sequence conservation in gene regulatory regions between species is a poor predictor of conserved functionality.

Noninvasive positive pressure ventilation is not predictive of acute respiratory failure after solid organ transplantation.

DRD1 proteins enable Pol V transcription in vivo.

Traditional reviews are biased in their interpretations.

The density of cytokine receptor bearing cells has no effect on the distance over which cytokines act.

The latent infection of myeloid cells with human cytomegalovirus induces a number of changes in gene expression.

Omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegetarians.

Urbanization is an important risk factor related to the transmission of dengue fever.

The number of unfertilized oocytes in mated hermaphrodites increases with age.

Pyridostatin stabilizes the G - quadruplex in the telomeric region.

Natriuretic peptides increase susceptibility to diabetes.


Side effects associated with antidepressants do not represent a mortality risk to postmenopausal women.

Deletion of ATM and Rad3 related protein is not predictive of acute tissue loss.

Individuals with Alzheimers who participate in six months of physical activity improve cognitive function for up to 18 months.

Mice without IFN-γ or its receptor are highly susceptible to EAM induced with α-MyHC/CFA.

Bacterial meningitis can be diagnosed on the basis of positive cerebrospinal fluid (CSF) cultures.

Hematopoietic Stem Cell purification reaches purity rates above 90%.

Gpr124 increases BBB breakdown in mouse models of ischemic stroke.

Omnivores produce less trimethylamine N-oxide from dietary I-carnitine than vegans.

Immune responses in immune cells are geographically segregated.

siRNA knockdown of A20 accelerates tumor progression in an in vivo murine xenograft model.

Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission.

Side effects associated with antidepressants increases risk of stroke.

Sildenafil worsens erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.

Side effects associated with antidepressants lower risk of myocardial infarction.

Antidepressants reduce the severity of migraines.

Antidepressants increase the severity of migraines.

A breast cancer patient's capacity to metabolize tamoxifen influences treatment outcome.

The most prevalent adverse events to Semaglutide are cardiovascular.

In young and middle-aged adults, current or remote uses of ADHD medications increase the risk of serious cardiovascular events.

Pioglitazone use is significantly associated with an increased risk of prostate cancer.


Side effects associated with antidepressants increases risk of stroke.

Mitochondria play a major role in apoptosis.

Asymptomatic visual impairment screening in elderly populations leads to improved vision.

Taxation of sugar-sweetened beverages reduced the incidence rate of type II diabetes in India.

Increased microtubule acetylation repairs interference of axonal transport caused by LRRK2 Roc-COR domain mutations.

Pro-inflammatory cytokines are up regulated during tumor development.

Osteoparthritis (OA) is characterized by degeneration of articular cartilage, joint edge, and subchondral bone hyperplasia.

TNFAIP3 is a tumor enhancer in glioblastoma.

Cost effectiveness evaluations based on cRCT data lack external validity.

The DEXI promoter region is bound by multiple transcription factors in a murine haematopoietic progenitor cell line.

Stroke patients with prior use of direct oral anticoagulants have a higher risk of in-hospital mortality than stroke patients with prior use of warfarin.

Dexamethasone increases risk of postoperative bleeding.


Side effects associated with antidepressants lower risk of myocardial infarction.

There was an estimated 30 million cases of pneumonia in young children worldwide in 2010.

61% of colorectal cancer patients are diagnosed with regional or distant metastases.

Microglia are an innate immune cell type of the peripheral nervous system.

Headaches are correlated with cognitive impairment.

Human embryonic stem cells give rise to cell types from the outer embryonic germ layer, but not the other two layers.

90% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.

RUNX1 is downregulated or mutated in TLX1 T-ALL.

Weighed food records (WFR) result in poor completion since they're costly to run and impose high participant burden.

H4 G94P proteins suppress degradation of free histones via Rad53-dependent mechanisms.

aPKCz causes tumour suppression by affecting glutamine metabolism.

The most prevalent adverse events to Semaglutide are gastrointestinal.

Pioglitazone use is significantly associated with an increased risk of pancreatic cancer.


Sildenafil worsens erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.

Charcoal is an effective treatment for acute paraquat poisoning.

COPI coatmer is involved in viral replication.

Low nucleosome occupancy correlates with high methylation levels across species.

AZT given with ribavirin increases anemia.

De novo assembly of sequence data has fewer specific contigs than unassembled sequence data.

Reduction of purity of cytoplasmic membranes isolated from overexpressors is indicated by stronger spots for OmpA in 2D BN-PAGE gels.

Low expression of miR7a does not repress target genes or exert a biological function in ovaries.

PD-1 triggering on monocytes enhances IL-10 production by monocytes.

There is no association between HNF4A mutations and diabetes risks.

Myelin sheaths play a role in action potential propagation.

Pioglitazone use is not associated with an increased risk of prostate cancer.

Amitriptyline is an effective treatment for chronic tension-type headaches.


Smc5/6 engagment halts the activation of SUMO E3 ligase Mms21 by ATP-dependent remolding.

Energy balance requires hypothalamic glutamate neurotransmission.

Sequence conservation in gene regulatory regions between species is a high-accuracy predictor of conserved functionality.

The tip of the inner tube of the toxic type VI secretion system (T6SS) antibacterial effector in Escherichia coli (E. coli) is decorated with VgrG and PAAR proteins.

There is a positive correlation between hip fractures and statin use.

MafA ubiquitination decreases the recruitment of coavtivator P/CAF by MafA.

Blocking the interaction between TDP-43 and respiratory complex I proteins ND3 and ND6 prevents TDP-43-induced neuronal loss.

Major vault protein regulates sorting of tumor suppressive miR-193a into EVs.

The proliferative capacity of neural progenitors differs across species.

Formation of N-terminal pyroglutamate by glutamine cyclase (GC) competes with NTAQ1 for Nt-Gln substrates.

PrimPol degrades short DNA replication intermediates on the leading strand during DNA replication.

JMJD6 catalyzes the hydroxylation of C-terminal lysine and supresses transcriptional activity.

Binding of p53 to enhancer regions (p53BERs) regulates the activity of p53 transcription and cell cycle arrest through the production of p53-dependent eRNAs.

Ribosome-inactivating protein-2 (RIP-2) interacts with the p75 NTR death domain

JMJD6 slows the hydroxylation of C-terminal lysine

The microtubule-dependent delivery and secretion of matrix metalloproteases (MMPs) is partially responsible for the disassembly of adhesion sites.

Intramembrane cleavage by signal peptide peptidase aids in the degradation of proteins with a complex membrane orientation.

p16INK4A degradation is encoded by CDKN2A.

Activation of PPM1D enhances p53 function.

H4 G94P proteins induce degradation of free histones via Rad53-dependent mechanisms.