Aggravated inflammation is dependent on NLRP3 inflammasome activation.

Adult tissue-resident macrophages are seeded before birth.

Sn is present on mature DCs during inflammation in vivo.

Increased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm.

Amitriptyline is an effective treatment for chronic tension-type headaches.

Nonhuman primates are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.

CD28 initiates tonic signaling in conventional T cells, which causes an exhaustion phenotype and limited efficiency.

The proliferative capacity of neural progenitors differs across species.

Origin gross domestic product(GDP) is positively related to dengue virus (DENV-1) diffusion in air traffic shipments.

Binding of p53 to enhancer regions (p53BERs) regulates the activity of p53 transcription and cell cycle arrest through the production of p53-dependent eRNAs.

The cytokine receptor which regulates chemotaxis and formation of lymph nodes is involved in production of myeloperoxidase in the left atrium.

PKG-la does not have a large impact on expression of pain hypersensitivity in PGK-la knockout mice.

PKG-la plays an essential role in expression of spinal long term potentiation in PGK-la knockout mice.

The NF-κB essential modulator gene induces intestinal inflammation by promoting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death.

Inhibiting focal adhesion formation increases the rate at which cells convert mechanical strain into inflammation and fibrosis.

PKG-la does not have a large impact on expression of spinal long term potentiation in PGK-la knockout mice.

The NF-κB essential modulator gene prevents intestinal inflammation by inhibiting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death.

Citrullinated proteins externalized in neutrophil extracellular traps act indirectly to perpetuate the inflammatory cycle via induction of autoantibodies.

Upon viral challenge, influenza-specific memory CD4+ T cells greatly diminish the early production of inflammatory chemokines in the lung.

Inhibiting focal adhesion formation enables cells to convert mechanical strain into eventual scarring.


Albendazole is used to treat soil-transmitted helminths.

Long chain polyunsaturated fatty acids supplementation is associated with lower rates of atopic eczema at 1 year.

Pioglitazone use is significantly associated with an increased risk of prostate cancer.

The one-child policy has created a hospitable environment for female infants.

The DESMOND program caused substantial weight loss in most participants.

ATM and Rad3 related protein are critical for sensing DNA damage.

Diabetic patients with acute coronary syndrome experience decreased short-term and long-term risk for bleeding events.

Perigenital skin is not the primary site of HIV acquisition.

Patients in stable partnerships progress from HIV to death at the same rate as patients not in partnerships.

APOE4 expression in iPSC-derived neurons results in decreased tau phosphorylation.

Helminths interfere with immune system control of coinfections by microbial pathogens 16.

Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission.

Eilat virus (EILV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in nonhuman primates.

Antimicrobial agents are less effective due to the pressure of antimicrobial usage.

Anthrax spores are very difficult to dispose once they are dispersed.

The DdrB protein from Deinococcus radiodurans functions as a pentamer.

Anthrax spores remain deadly until affected areas are decontaminated.

Antimicrobial agents are more effective due to the pressure of antimicrobial usage.

Urbanization is an important risk factor related to the transmission of dengue fever.


Algerian physicians constitue the largest component of sub-Saharan Africa-trained physicians in the United States.

Upregulation of PD1 causes the upregulation of Satb1.

Beta-band coherence is diminished for visible stimuli over invisible stimuli.

Mutant mice lacking SVCT2 have severely reduced ascorbic acid levels in both brain and adrenals.

The effect of Lipopolysaccharides on kidney barrier function is dependent on inflammation levels.

Bariatric surgery reduces colorectal cancer.

Patients with microcytosis and higher erythrocyte count were more resistant to severe malarial anaemia when infected with Plasmodium falciparum.

50% of patients exposed to radiation have activated markers of mesenchymal stem cells.

DMS3 protein enables Pol V transcription in vivo.

MafA ubiquitination decreases the recruitment of coavtivator P/CAF by MafA.

p16INK4A degradation is encoded by CDKN2A.

Nigerian physicians constitue the largest component of sub-Saharan Africa-trained physicians in the United States.

Students who perform poorly in the early years of medical school are less likely to commit professional misconduct later in their careers.

Students who perform poorly in the early years of medical school are at increased risk for professional misconduct later in their careers.

Risk-adjusted mortality rates are similar in teaching and non-teaching hospitals.

76-85% of people with severe mental disorder receive no treatment in low and middle income countries.

The World Health Organization's (WHO) data collection process is biased downward by unequal selection of larger outbreaks.

70% of burn patients are admitted for hospitalization and further treatment after appearing at hospital emergency wards or outpatient clinics.

Tuberculosis incidence occurs at higher rates in more sparsely populated areas in the UK.


Alirocumab treatment reduces apo(a) fractional clearance rate.

Prescribed exercise training improves quality of life.

Omnivores produce less trimethylamine N-oxide from dietary I-carnitine than vegans.

The predominant localization of Linc00173 is in mononuclear macrophage nuclei.

Human embryonic stem cells give rise to cell types from the outer embryonic germ layer, but not the other two layers.

Sympathetic nerve activity is elevated throughout normal pregnancy.

One in five surgical randomized controlled trials are discontinued early.

Pioglitazone use is significantly associated with an increased risk of pancreatic cancer.

The risk of female prisoners harming themselves is ten times that of male prisoners.

Metastatic colorectal cancer treated with a single agent fluoropyrimidines resulted in similar efficacy and better quality of life when compared with oxaliplatin-based chemotherapy in elderly patients.

Bariatric surgery reduces postmenopausal breast cancer.

AZT given with ribavirin increases anemia.

Taking anti-depresents is associated with a decrease in the Aβ level in the brain of experimental animals.

MafA ubiquitination decreases the recruitment of coavtivator P/CAF by MafA.

The most prevalent adverse events to Semaglutide are gastrointestinal.

MafA ubiquitination increases the recruitment of coavtivator P/CAF by MafA.

Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission.

The most prevalent adverse events to Semaglutide are cardiovascular.

A 100g dose of chloroquine chemoprophylactic regimen results in retinal toxicity after 1 year of weekly intake.

Treatment with the EC uptake inhibitor AM404 resulted in a dose-dependent decrease in the expression of immobility.


Allogeneic mechanical circulatory support is not as effective as autologous mechanical circulatory support for treating acute myocardial infarction.

At least 85% of patients exposed to radiation have activated markers of myofibroblasts.

HOXB4 is a highly expressed component of cellular secretome from fetal liver cell populations.

The first MBT repeat of the four malignant brain tumor (4MBT) domain of Drosophila's Sfmbt and of the orthologous mammalian L3MBTL2 is required for the interaction with the spacer region of Drosophila's Pleiohomeotic (Pho) or its human ortholog YY1.

Foxk2 regulates autophagy genes in muscle cells and fibroblast cells.

Insulin decreases risk of severe kidney failure.

PGE 2 suppresss intestinal tumor growth by altering the expression of tumor suppressing and DNA repair genes.

Assessing treatment adherence is more beneficial to clinical practice than measuring routine outcomes.

Mutations in G-Beta protein GNB1 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.

Mice without IFN-γ or its receptor are highly susceptible to EAM induced with α-MyHC/CFA.

Patients with common epithelial cancers  are more likely to have an emergency event as their first hospital admission if they live in resource-deprived areas.

Noninvasive positive pressure ventilation is not predictive of acute respiratory failure after solid organ transplantation.

Sudden death can occur in patients with complex ventricular arrhythmias.

Sudden death can occur in patients with orthostatic hypertension without cardiac conduction abnormalities.

The myocardial cell lineage originally develops from cardiac progenitors of exclusively endodermal origin.

Stroke patients with prior use of direct oral anticoagulants have a higher risk of in-hospital mortality than stroke patients with prior use of warfarin.

Osteoparthritis (OA) is characterized by degeneration of articular cartilage, joint edge, and subchondral bone hyperplasia.

Inhibiting focal adhesion formation increases the rate at which cells convert mechanical strain into inflammation and fibrosis.

Surgical treatment is not superior to non-surgical in treating adults with displaced fractures of the proximal humerus.

CRP is positively correlated with postoperative mortality following Coronary Artery Bypass Graft (CABG) surgery.


Alteration of origin firing causes changes in termination zones of Okazaki fragments.

PCSK9 inhibitors decrease plasma Lp(a) levels.

Forkhead 0 (fox0) transcription factors are involved in cellular differentiation.

Osteocytes have an essential role in G-CSF induced HSPC mobilization.

Klf2 is important for proper myeloid cell function.

Kir7.1 modulates channel activity by the G protein-coupled melanocortin-4 receptor (MC4R) in the paraventricular nucleus of the hypothalamus.

miR-142-5P is a temperature-sensitive microRNA (miRNA).

A country's Vaccine Alliance (GAVI) eligibility is not indictivate of accelerated adoption of the Hub vaccine.

Oxidative DNA damage activates STING signalling.

Immune complex triggered cell death leads to sequestration of oxidized mitochondrial DNA.

Cyclin A2 destruction is necessary to switch from unstable to stable kt-mt attachments in mitosis.

Most termination events in Okazaki fragments are dictated by initiation patterns.

Acute ablation of Snail in the embryonic cortex affects the proliferation and number of embryonic cortical precursors.

Inhibiting focal adhesion formation enables cells to convert mechanical strain into eventual scarring.

Immune complex triggered cell death leads to extracellular release of nuclear DNA.

Cellular clocks are associated with mitosis timing in NIH 3T3 cells.

Cellular clocks are not predictive of mitosis timing in NIH 3T3 cells.

Recognition of start codons depends on the translation initiation factor IF3.

Pyridostatin encourages proliferation of homologous recombination - defective cells.


Ambulatory blood pressure monitoring is inaccurate at diagnosing hypertension.

BLM gene encodes RecQ-class DNA helicase.

Antidepressants increase the severity of migraines.

Expression of MSX2 is induced 3 hours after the addition of BMP4, which is earlier than T and CDX2.

Egr2 regulates the homeostasis of B and T cells.

Adult tissue-resident macrophages stem from the embryonal yolk sac and fetal liver.

Incidence of 10/66 dementia is lower than the incidence of DSM-IV dementia.

A single nucleotide variant the gene DGKK is strongly associated with increased risk of hypospadias.

Treatment with a protein named FN restores regenerative abilities of aged muscles.

Decreased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm.

Increased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm.

Sudden death can occur in patients with orthostatic hypertension without cardiac conduction abnormalities.

Nonhypertensive people who are 55 years old have a 90% chance of developing hypertension during their lifetime.

Noninvasive positive pressure ventilation is not predictive of acute respiratory failure after solid organ transplantation.

Insulin decreases risk of severe kidney failure.

Risk of cardiovascular events can be cut by a third by using antihypertensive drug therapy among hemodialysis patients.

CRP is positively correlated with postoperative mortality following Coronary Artery Bypass Graft (CABG) surgery.

Diabetic patients with acute coronary syndrome experience decreased short-term and long-term risk for bleeding events.


Amitriptyline is an effective treatment for chronic tension-type headaches.

Allogeneic mechanical circulatory support is not as effective as autologous mechanical circulatory support for treating acute myocardial infarction.

Cytosolic proteins bind to iron-responsive elements on mRNAs coding for TFRC1.

The cytokine receptor which regulates chemotaxis and formation of lymph nodes is involved in production of myeloperoxidase in the left atrium.

Replacement of OCT4 and SOX2 genes with GATA3 has the ability to reprogram human cells.

Incidence of sepsis has fallen substantially from 2009 to 2014.

Intake of folic acid (FA) and vitamin B6 (VB6) increases levels of homocysteine.

The World Health Organization's (WHO) data collection process is biased downward by unequal selection of larger outbreaks.

During the primary early antibody response activated B cells migrate toward the inner-and outer follicular areas where oxysterol accumulation is generated by stromal cells.

90% of patients with melanoma and an objective response to PD-1 blockade will experience a progression in their melanoma.

Antidepressants reduce the severity of migraines.

Antidepressants increase the severity of migraines.

Sildenafil worsens erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.

Side effects associated with antidepressants increases risk of stroke.

Side effects associated with antidepressants do not represent a mortality risk to postmenopausal women.

Pioglitazone use is significantly associated with an increased risk of prostate cancer.

Cognitive behavioral therapy is an ineffective treatment for insomnia

Pioglitazone use is not associated with an increased risk of prostate cancer.

Varenicline monotherapy is more effective after 26 weeks of treatment compared to combination nicotine replacement therapies with varenicline or bupropion.


An M2-like phenotype in brown adipose tissue macrophages is quickly induced by cold exposure.

Taking 400mg of α-tocopheryl acetate does not prevent prostate cancer.

A diminished ovarian reserve is a very strong indicator of infertility, even in an a priori non-infertile population.

YAP/TAZ is required in intestinal regeneration in mouse models of ulcerative colitis.

Diabetes remission occurs more in people treated with conventional therapy than in people treated with laparoscopic adjustable gastric banding surgery.

The first MBT repeat of the four malignant brain tumor (4MBT) domain of Drosophila's Sfmbt and of the orthologous mammalian L3MBTL2 is required for the interaction with the spacer region of Drosophila's Pleiohomeotic (Pho) or its human ortholog YY1.

Side effects associated with antidepressants increases risk of stroke.

Removal of H3K9me3 by ectopic expression of other H3K9 demethylases decreases reprogramming efficiency in SCNT experiments.

A deficiency of folate increases blood levels of homocysteine.

Toll-like receptor (TLR) signaling is involved in the pathogenesis of human MDS.

Anthrax spores remain deadly until affected areas are decontaminated.

The M2-phenotype in brown adipose tissue macrophages increases brown adipose tissue thermogenic activity.

The morphology change from large white adipocytes to small brown adipocytes is a sign of decreased energy expenditure potential in white adipose tissue.

The morphology change from large white adipocytes to small brown adipocytes is a sign of increased energy expenditure potential in white adipose tissue.

Chenodeoxycholic acid treatment decreases brown adipose tissue activity.

Chenodeoxycholic acid treatment increases brown adipose tissue activity.

Ca2+ cycling controls whole-body energy homeostasis in beige fat.

Ethanol stress reduces the expression of SRL in bacteria.

Ethanol stress increases the expression of SRL in bacteria.

aPKCz causes tumour suppression by affecting glutamine metabolism.


Androgenetic haploid mouse embryonic stem cells (ESCs) can be derived and genetically manipulated in vitro.

Mice defective for deoxyribonucleic acid (DNA) polymerase I (polI) fail to reveal increased sensitivity to ionizing radiation (IR).

Female carriers of the Apolipoprotein E4 (APOE4) allele have increased risk for Alzheimer's disease.

Certain immunomodulator-human dialyzable leukocyte extract (hDLE) peptides are recognized by toll-like receptors (TLRs) on macrophages and dendritic cells.

The artifactual C-terminal helix swapping in the StART domain is observed in the Ups1-Mdm35 heterodimer of the StARkin superfamily.

B3-Galectin increases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR.

ScPif1p has reduced binding ability to G-rich ssDNA compared to non-G-rich ssDNA.

qSOFA scores are associated with length of stay in emergency department patients.

Vitamin D is an important factor in the relationship between calcium and parathyroid hormone.

Varenicline monotherapy is more effective after 26 weeks of treatment compared to combination nicotine replacement therapies with varenicline or bupropion.

Origin gross domestic product(GDP) is positively related to dengue virus (DENV-1) diffusion in air traffic shipments.

Human embryonic stem cells have the capacity to give rise to differentiated progeny representative of all three embryonic germ layers.

Human embryonic stem cells give rise to cell types from all three embryonic germ layers.

Human embryonic stem cells give rise to cell types from the outer embryonic germ layer, but not the other two layers.

Mouse models can be generated using "artificial spermatids."

Specialized functional cell types can be derived from human pluripotent stem cells.

Cellular differentiation of embryonic stem cells is accompanied by changes in replication timing, transcription and nuclear localization.

Transplanted human glial progenitor cells can mature in their host animal.

In pediatric tissue, most T cells are naive T cell emigrants from the thymus.

Induced hepatic stem cells possess the potential to differentiate into cholangiocytic cells.


Angiotensin converting enzyme inhibitors are associated with decreased risk for functional renal insufficiency.

The innate immune response struggles to remove small numbers of parasites.

Approximately 250,000 people are infected with human T-cell lymphotropic virus type 1 in the United Kingdom.

YAP/TAZ is required in intestinal regeneration in mouse models of ulcerative colitis.

Deletion of ATM and Rad3 related protein leads to acute tissue loss.

Pediatric SCD patients with vaso-occlusive crisis show increased morphine use after breathing 80 ppm iNO for 4 hours.

British male students are bullied more than British female students.

GATA3 regulates cell cycle progression in bone marrow hematopoietic stem cells.

N348I mutations cause resistance to nevirapine.

JMJD6 slows the hydroxylation of C-terminal lysine

NAC destabilizes NO to increase the effect of contrast agents on renal functions.

40mg/day dosage of folic acid and 2mg/day dosage of vitamin B12 does not affect chronic kidney disease (CKD) progression.

The effect of Lipopolysaccharides on kidney barrier function is dependent on inflammation levels.

NAC inhibits the generation of angiotensin-converting enzyme.

Insulin decreases risk of severe kidney failure.

Autophagy deficiency in the liver increases vulnerability to insulin resistance.

A deficiency of folate increases blood levels of homocysteine.

A deficiency of vitamin B12 decreases blood levels of homocysteine.

Lipopolysaccharides have an inflammation independent effect on kidney barrier function.


Anthrax spores are very difficult to dispose once they are dispersed.

Cellular clocks are associated with mitosis timing in NIH 3T3 cells.

Aged patients are more susceptible to ischaemia/reperfusion injury.

Diabetes remission occurs less in people treated with conventional therapy than in people treated with laparoscopic adjustable gastric banding surgery.

PKG-la does not have a large impact on expression of pain hypersensitivity in PGK-la knockout mice.

Androgenetic haploid mouse embryonic stem cells (ESCs) can be derived and genetically manipulated in vitro.

Cellular differentiation of embryonic stem cells is accompanied by changes in replication timing, transcription and nuclear localization.

Ly49Q directs the organization of neutrophil polarization by regulating membrane raft functions.

V-9302 inhibits antitumor responses by decreasing cell death and oxidative stress.

Normal expression of RUNX1 causes tumorsupressing effects.

Anthrax spores remain deadly until affected areas are decontaminated.

Tuberculosis-induced granulomas express different immune system protein signatures than the surrounding tissue.

The tissue surrounding the granuloma in an immune cell induces an anti-inflammatory immune response.

Inside the body, falciparum parasites reproduce asexually.

Nonhuman primates are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.

Eilat virus (EILV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in nonhuman primates.

A low percentage of hematopoietic progenitor cells are susceptible to HIV-1 infection ex vivo.

Charcoal is an effective treatment for acute paraquat poisoning.

Gastric infection with Helicobacter pylori decreases risk of gastric cancer in humans.


Anthrax spores remain deadly until affected areas are decontaminated.

RA activation of DIF2 and NB4 cells induces hallmarks of transcriptionally active promoters.

Pyridostatin induces checkpoint activation.

Helicobacter pylori-induced aberrant NF-kB-dependent expression of activation-induced cytidine deaminase contributes to the mutagenesis of host DNA.

Omnivores produce less trimethylamine N-oxide from dietary I-carnitine than vegans.

Post-transcriptional handling of mitochondrial transcripts occurs in mitochondrial RNA granules.

Low expression of miR7a does not repress target genes or exert a biological function in testis.

The amount of publicly available DNA data doubles every 10 months.

Genomic sequences involved in alternative splicing responsible for Hutchinson-Gilford progeria syndrome (HGPS) are abundant in the ''progerinonly'' allele of Lmna knock-in models.

MFGE8 regulates fat absorption by binding to av-Beta3 and av-Beta5 integrins.

Ethanol stress reduces the expression of SRL in bacteria.

Rising temperatures caused by global warming lowers the risk of dengue fever transmission.

Rising temperatures caused by global warming increases risk of dengue fever transmission.

Urbanization is an important risk factor related to the transmission of dengue fever.

The innate immune response struggles to remove small numbers of parasites.

Charcoal shows no benefit for acute paraquat poisoning.


Antidepressants increase the severity of migraines.

For every 1,000 children with cerebral palsy, more than 300 of them are premature or underweight at birth.

Surgical treatment is not superior to non-surgical in treating adults with displaced fractures of the proximal humerus.

Lack of FGF21 in mice leads to reduced lifespan.

A deficiency of folate increases blood levels of homocysteine.

Enhanced early production of inflammatory chemokines damages viral control in the lung.

Incidence of sepsis has fallen substantially from 2009 to 2014.

The ability of activator E2Fs in preventing cell death is limited to terminally differentiated cells.

The PDPN gene deactivates the C-type lectin receptor (CLEC-2).

Cognitive behavioral therapy is an ineffective treatment for insomnia

Binding of p53 to enhancer regions (p53BERs) regulates the activity of p53 transcription and cell cycle arrest through the production of p53-dependent eRNAs.

Antidepressants reduce the severity of migraines.

Side effects associated with antidepressants increases risk of stroke.

Side effects associated with antidepressants do not represent a mortality risk to postmenopausal women.

Sildenafil worsens erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.

Side effects associated with antidepressants lower risk of myocardial infarction.

Headaches are correlated with cognitive impairment.

Amitriptyline is an effective treatment for chronic tension-type headaches.

Patients with panic anxiety show decreased CSF levels of hypocretin.

In young and middle-aged adults, current or remote uses of ADHD medications increase the risk of serious cardiovascular events.


Antidepressants reduce the severity of migraines.

Flexible molecules experience less steric hindrance in the tumor microenviroment than rigid molecules.

Microcin J25 inhibits nucleoside triphosphate (NTP) binding.

Patients with microcytosis and higher erythrocyte count are more vulnerable to severe malarial anaemia when infected with Plasmodium falciparum.

Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes fibrosis.

A diminished ovarian reserve does not solely indicate infertility in an a priori non-infertile population.

Aged patients are less susceptible to ischaemia/reperfusion injury.

Allogeneic mechanical circulatory support is not as effective as autologous mechanical circulatory support for treating acute myocardial infarction.

Toll-like receptor (TLR) signaling is involved in the pathogenesis of human MDS.

There was an estimated 30 million cases of pneumonia in young children worldwide in 2010.

cSMAC formation represses weak ligand signalling.


Antimicrobial agents are less effective due to the pressure of antimicrobial usage.

Genetic deficiency of mast cells leads to decreased weight gain in a mouse model of diet-induced obesity.

The composition of myosin-II isoform switches from the A isoform to the B isoform during hematopoietic differentiation.

Ambulatory blood pressure monitoring is inaccurate at diagnosing hypertension.

The peak incidence of fractures occurs during pubertal growth spurt in early adolescents.

Basophils promote disease development in patients with systemic lupus erythematosus (SLE).

PCSK9 inhibitors decrease plasma Lp(a) levels.

The proportion of people with visual difficulty is two times higher in low-income countries than in high-income countries.

50% of patients exposed to radiation have activated markers of mesenchymal stem cells.

Sn is present on mature DCs during inflammation in vivo.

HOXB4 facilitates HSC expansion when co-cultured with HSCs.

Antimicrobial agents are more effective due to the pressure of antimicrobial usage.

Increased flux of microbial products provokes immune responses.

Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission.

Increased flux of microbial products suppresses immune responses.

The most prevalent adverse events to Semaglutide are cardiovascular.

The most prevalent adverse events to Semaglutide are gastrointestinal.

Systemic immunosuppressive (IS) therapy increases the chance of cancer mortality in patients with inflammatory eye disease (IED)

Systemic immunosuppressive (IS) therapy does not enhance the chance of cancer mortality in patients with inflammatory eye disease (IED)


Antimicrobial agents are more effective due to the pressure of antimicrobial usage.

32% of liver transplantation programs required patients to discontinue methadone treatment in 2001.

Ly49Q directs the organization of neutrophil polarization by regulating membrane raft functions.

Cancers that initially benefit from epidermal growth factor receptor targeted therapies later become refractory through several mechanisms.

A single nucleotide variant the gene DGKK is strongly associated with increased risk of hypospadias.

The ability of activator E2Fs in preventing cell death is limited to terminally differentiated cells.

Environmental factors can influence the development of breast cancer.

Insulin decreases risk of severe kidney failure.

Commelina yellow mottle virus' (ComYMV) genome consists of 2140 baise pairs.

FoxO3a activation in neuronal death is inhibited by reactive oxygen species (ROS).

Side effects associated with antidepressants increases risk of stroke.


Antiretroviral therapy increases rates of tuberculosis across a broad range of CD4 strata.

Primary cervical cytology screening with HPV detection has higher longitudinal sensitivity to detect severe cervical intraepithelial neoplasia than conventional cytology.

IL-6 signaling plays a major role in atherosclerotic cardiovascular disease.

Repressing IL-18 has negative effects on atherosclerotic lesion composition and progression.

mcm 5 s 2 U is required for proper decoding of NNR codons in eukaryotes.

VgrG (Tssl) protein punctures membranes by forming a spike at the tip of the tube apparatus.

Long chain polyunsaturated fatty acids supplementation is associated with lower rates of atopic eczema at 1 year.

Roughly 55% of women with chronic pelvic pain have no underlying pathology.

Comparative transcriptome analysis identified new platelet proteins with structural features suggesting a role in platelet function.

Chronic HIV stimulation of B cells leads to the premature exhaustion of B cells.

BCL-2 activation antagonizes the apoptotic effects of c-Myc.

Tuberculosis incidence occurs at higher rates in more sparsely populated areas in the UK.

Tuberculosis-induced granulomas express different immune system protein signatures than the surrounding tissue.

Exhaustion of B cells contributes to poor Ab response in HIV-infected individuals.

Taking anti-depresents is associated with a decrease in the Aβ level in the brain of experimental animals.

Antidepressants reduce the severity of migraines.

In patients with congenital heart defects, β-blockers significantly improve clinical heart failure outcomes.


Approximately 250,000 people are infected with human T-cell lymphotropic virus type 1 in the United Kingdom.

Reduced levels of lipolysis leads to higher P38 phosphorylation in adipose tissue.

The deregulated and prolonged activation of monocytes has deleterious effects in chronic infectious conditions.

Bacteriophagaes MS2 and Qβ are members of the Leviviridae.

Systemic lupus erythematosus is a risk factor for cardiovascular disease.

Homozygous deletion of murine Sbds gene from osterix-expressing mesenchymal stem and progenitor cells (MPCs) induces oxidative stress.

Fibroblast Growth Factor is a ligand which signals through receptor tyrosine kinases.

Ethanol stress increases the expression of SRL in bacteria.

Expression of oncolytic virus antigens as peptides permits additional protection against relapse.

Glycan adaptation is rarely observed in the B-cell repertoire.

Long - range chromatin interactions regulate transcription.

In pediatric tissue, most T cells are naive T cell emigrants from the thymus.

There was an estimated 30 million cases of pneumonia in young children worldwide in 2010.

Ten percent (10%) of kidney cancers in the UK are attributable to excess weight.

Eilat virus (EILV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in nonhuman primates.

The latent infection of myeloid cells with human cytomegalovirus induces a number of changes in gene expression.

A low percentage of hematopoietic progenitor cells are susceptible to HIV-1 infection ex vivo.

A T helper 2 cell (Th2) environment impedes disease development in patients with systemic lupus erythematosus (SLE).

Bone Marrow (BM) transplantation is used to treat acute myeloid leukemia (AML)


Assessing treatment adherence is more beneficial to clinical practice than measuring routine outcomes.

In transgenic mice harboring green florescent protein under the control of the Sox2 promoter, more than 50 percent of the cells with green florescent colocalize with cell proliferation markers.

Distant CREs are less conserved among species.

1-1% of colorectal cancer patients are diagnosed with regional or distant metastases.

EG7 tumors can be killed by systemic oxaliplatin primed CD8+ T cells from the tumor-draining lymph node cells.

Rising temperatures caused by global warming increases risk of dengue fever transmission.

Early patent ductus ateriosus (PDA) screening decreases in-hospital mortality.

The risk of cancer rises with level of alcohol consumption.

The combination of physical examinations with C-reactive protein values do not improve the accuracy of radiographic verified pneumonia predictions.

MafA ubiquitination increases the recruitment of coavtivator P/CAF by MafA.

Measuring routine outcomes is more beneficial to clinical practice than assessing treatment adherence.

Cost effectiveness evaluations based on cRCT data accurately reflect prices for patients in actual clinical practice.

Misunderstandings between doctors and patients can lead to non-adherence.

Including pharmacists in rounding teams does not alter the incidence of adverse drug events (ADEs).

Including pharmacists in rounding teams reduces the incidence of adverse drug events (ADEs).

Cost effectiveness evaluations based on cRCT data lack external validity.

Integrated care is ineffective at tackling multiple comorbidities.

Integrated care is successful at tackling multiple comorbidities.

Therapeutics receiving accelerated approval encounter a lower frequency of post-marketing safety events


Asymptomatic visual impairment screening in elderly populations leads to improved vision.

The gene daf-16, which encodes forkhead Box O (FOXO), is required for all phenotypes associated with reduced insulin/insulin-like growth factor (Igf) signaling.

miRNAs regulate a unique suite of mRNAs to maintain homeostasis in cells.

Bone marrow cells don't contribute to adult macrophage compartments.

Having a main partner improves HIV outcomes.

The C-type lectin receptor (CLEC-2) rearranges the actin cytoskeleton in dendritic cells to promote efficient motility along stromal surfaces.

Pyridostatin prevents double-strand breaks accumulation.

PGE 2 suppresss intestinal tumor growth by altering the expression of tumor suppressing and DNA repair genes.

Stroke patients with prior use of direct oral anticoagulants have a higher risk of in-hospital mortality than stroke patients with prior use of warfarin.

Algerian physicians constitue the largest component of sub-Saharan Africa-trained physicians in the United States.

There is no relation between Erythromycin use and hypertrophic pyloric stenosis.

Headaches are correlated with cognitive impairment.

Physical activity does not improve cognitive function in individuals with Alzheimers.

Individuals with Alzheimers who participate in six months of physical activity improve cognitive function for up to 18 months.

Incidence of 10/66 dementia is lower than the incidence of DSM-IV dementia.

Incidence of 10/66 dementia is higher than the incidence of DSM-IV dementia.

In young and middle-aged adults, current or remote uses of ADHD medications increase the risk of serious cardiovascular events.

Female carriers of the Apolipoprotein E4 (APOE4) allele have decreased risk for dementia.

Female carriers of the Apolipoprotein E4 (APOE4) allele have increased risk for Alzheimer's disease.

Nonhypertensive people who are 55 years old have a 90% chance of developing hypertension during their lifetime.


At least 85% of patients exposed to radiation have activated markers of myofibroblasts.

Chlamydia trachomatis is most prevalent in the UK among individuals in their 50s and 60s.

Mice are incapable of producing neutralizing antibodies in reponse to the Chikungunya virus (CHIKV) produced in mosquitos.

Splenomegaly is observed in knockin mouse lacking the SHP-2 MAPK pathway.

The risk of female prisoners harming themselves is ten times that of male prisoners.

DRD1 proteins enable Pol V transcription in vivo.

Intramembrane cleavage by signal peptide peptidase aids in the degradation of proteins with a complex membrane orientation.

A deficiency of vitamin B12 decreases blood levels of homocysteine.

70% of burn patients are admitted for hospitalization and further treatment after appearing at hospital emergency wards or outpatient clinics.

Hematopoietic Stem Cell purification reaches purity rates above 90%.

Excess gestational weight gain is associated with obesity-related pregnancy outcomes.

Less than 10% of patients exposed to radiation have activated markers of mesenchymal stem cells.

50% of patients exposed to radiation have activated markers of mesenchymal stem cells.

Cancer-associated fibroblasts (CAFs) have no known interaction with cancer cells in the formation and activation of CAFs.

1-1% of colorectal cancer patients are diagnosed with regional or distant metastases.

61% of colorectal cancer patients are diagnosed with regional or distant metastases.

Cancer-associated fibroblasts (CAFs) interact with cancer cells to mediate formation and activation of CAFs.

Cancer-associated fibroblasts (CAFs) are constituents of tumor microenvironments

Pro-inflammatory cytokines are up regulated during tumor development.

Tumor development occurs in conjunction with upregulation of pro-inflammatory cytokines.


Autologous transplantation of mesenchymal stem cells has better graft function than induction therapy with anti-interleukin-2 receptor antibodies.

JMJD6 slows the hydroxylation of C-terminal lysine

Integrating classroom-based collaborative learning with Web-based collaborative learning offers the best class performance.

One in two surgical randomized controlled trials are discontinued early.

Cognitive behavioral therapy is an ineffective treatment for insomnia

The NF-κB essential modulator gene induces intestinal inflammation by promoting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death.

Reducing H3k4me3 methylation induces mouse epiblast stem cells to naive pluripotency efficiently.

Deregulation of HAND2 is a crucial step in endometrial carcinogenesis in mice.

The minor G allele of FOXO3 is related to less severe symptoms of Crohn's Disease.

The NF-κB essential modulator gene prevents intestinal inflammation by inhibiting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death.

Oxidative phosphorylation is one of the primary glycometabolic pathways in cells.

Bone Marrow (BM) transplantation is used to treat acute myeloid leukemia (AML)

Transplanted human glial progenitor cells can mature in their host animal.

Induced hepatic stem cells possess the potential to differentiate into cholangiocytic cells.

In breast cancer, the loss of myoepithelial cells slows the transition of ductal carcinoma in situ to invasive carcinoma.

Homozygous deletion of murine Sbds gene from osterix-expressing mesenchymal stem and progenitor cells (MPCs) induces oxidative stress.

In breast cancer, the loss of myoepithelial cells promotes the transition of ductal carcinoma in situ to invasive carcinoma.

Repressing IL-18 has negative effects on atherosclerotic lesion composition and progression.

Allogeneic mechanical circulatory support is not as effective as autologous mechanical circulatory support for treating acute myocardial infarction.

Systemic immunosuppressive (IS) therapy increases the chance of cancer mortality in patients with inflammatory eye disease (IED)


Autophagy deficiency in the liver increases vulnerability to insulin resistance.

Differentiation of progenitor cells to myeloid cells is skewed when insulin signaling is suppressed.

Chronic HIV stimulation of B cells leads to the premature exhaustion of B cells.

At least 85% of patients exposed to radiation have activated markers of myofibroblasts.

Pyridostatin deregulates G2/M progression.

Increased mobility of retrotransposons is assosciated with mutation and higher tumorigenesis rates.

A 100g dose of chloroquine chemoprophylactic regimen results in retinal toxicity after 1 year of weekly intake.

Bariatric surgery reduces postmenopausal breast cancer.

Human embryonic stem cells give rise to cell types from all three embryonic germ layers.

Surgical treatment is not superior to non-surgical in treating adults with displaced fractures of the proximal humerus.

Insulin decreases risk of severe kidney failure.

Insulin effects appetite via ventral tegmental neurons.

Medications to treat obesity have unwanted side effects.

Medications to treat obesity do not have side effects.

A deficiency of folate increases blood levels of homocysteine.

Mice lacking Sirt1 in Sf1-expressing neurons have increased susceptibility to diet-induced obesity and insulin resistance.

Angiotensin converting enzyme inhibitors are associated with decreased risk for functional renal insufficiency.

Ethanol stress increases the expression of IBP in bacteria.

A mutation in HNF4A leads to an increased risk of developing diabetes by the age of 14 years.


B cells go though plasmablast differentiation and antibody production by continuous expression of EBI2.

RTEL1 interacts with TRF2 through a C4C4 motif

Hypothalamic glutamate neurotransmission is unrelated to energy balance.

H4 G94P proteins inhibit chromatin assembly, which decreases free histones.

Cis-acting lncRNAs control the expression of genes that are positioned in the vicinity of their transcription sites.

The proportion of people with visual difficulty is two times higher in low-income countries than in high-income countries.

MICAL redox enzymes regulate actin dynamics.

Forkhead 0 (fox0) transcription factors are involved in cellular differentiation.

Bone marrow cells don't contribute to adult macrophage compartments.

The recruitment of Wdr5 to its target loci depends on Kat8.

Trans-acting factors, such as lncRNAs, influence mRNA translation.

Varying expression levels of EBI2 affect the positioning and migration of B cells.

Egr2 regulates the homeostasis of B and T cells.

Egr3 regulates the homeostasis of B and T cells.

Neutrophils produce IL-1β in response to large particles.

During the primary early antibody response activated B cells migrate toward the inner-and outer follicular areas where oxysterol accumulation is generated by stromal cells.

The composition of myosin-II isoform switches from the A isoform to the B isoform during hematopoietic differentiation.

Transcription factor EB induces transcription of pro-inflammatory cytokines in macrophages infected with Staphylococcus aureus.

Exhaustion of B cells contributes to poor Ab response in HIV-infected individuals.


B3-Galectin decreases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR.

Vitamin D deficiency effects birth weight.

The minor G allele of FOXO3 up-regulates IL-10.

Cost effectiveness evaluations based on cRCT data lack external validity.

Increased microtubule acetylation exacerbates LRRK2 Roc-COR domain mutation induced locomotor deficits.

NAC inhibits the generation of angiotensin-converting enzyme.

CCL19 is predominantly present within dLNs.

Treatment with a protein named FN impairs regenerative abilities of aged muscles.

There is a positive correlation between hip fractures and statin use.

Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission.

Primary cervical cytology screening with HPV detection has higher longitudinal sensitivity to detect severe cervical intraepithelial neoplasia than conventional cytology.

B3-Galectin increases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR.

ITAM phosphorylation allows for the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).

Blocking the interaction between TDP-43 and respiratory complex I proteins ND3 and ND6 prevents TDP-43-induced neuronal loss.

MUC1-C activates the NF-κB p65 signaling pathway by interacting with IκB kinase ß.

Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes fibrosis.

C2 works synergistically with A-769662 to activate dephosphorylated AMPK.

Kir7.1 modulates channel activity by the G protein-coupled melanocortin-4 receptor (MC4R) in the paraventricular nucleus of the hypothalamus.

Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes epithelial damage.


B3-Galectin increases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR.

Input from  mental and physical health care professionals is not effective at decreasing homelessness.

Aged patients are less susceptible to ischaemia/reperfusion injury.

Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes fibrosis.

The US health care system can save up to $5 billion if 7% of patients waiting for kidney transplants participate in the optimized national kidney paired donation program.

Anthrax spores remain deadly until affected areas are decontaminated.

Cell autonomous sex determination in somatic cells occurs in Galliformes.

Low expression of miR7a does not repress target genes or exert a biological function in ovaries.

Distant CREs are important for transcriptional regulation.

Mice defective for deoxyribonucleic acid (DNA) polymerase m (polm) fail to reveal increased sensitivity to ionizing radiation (IR).

In a naive state, blocking Wingless-Int-1 secretion from mouse embryonic stem cells inhibits self-renewal of the mouse embryonic stem cells.

MEK inhibitors are effective treatments in RAS-driven mouse models of cancer.


BCL-2 activation antagonizes the apoptotic effects of c-Myc.

Replacement of histone H2A with H2A.Z accelerates gene activation in yeasts by destabilizing +1 nucleosomes.

Nonhuman primates are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.

The recruitment of Wdr5 to its target loci depends on Kat8.

Including pharmacists in rounding teams does not alter the incidence of adverse drug events (ADEs).

Exposure to fine particulate air pollution is unrelated to anxiety prevalence.

BCL-2 promotes the apoptotic effects of c-Myc.

Aggravated inflammation is dependent on NLRP3 inflammasome activation.

Radioiodine treatment of non-toxic multinodular goitre increases thyroid volume.

CD44v6 is not associated with constitutive and reprogrammed cancer stem cells driving cancer metastasis.

1-1% of colorectal cancer patients are diagnosed with regional or distant metastases.

Reduced phosphorylation of PP2A increases HDAC4 dephosphorylation by enhancing PP2A-HDAC4 interaction.

Reduced phosphorylation of PP2A suppresses HDAC4 dephosphorylation.

Cytochrome c is transferred from cytosol to the mitochondrial intermembrane space during apoptosis.

The PDPN gene deactivates the C-type lectin receptor (CLEC-2).

Gpr124 suppresses BBB breakdown in mouse models of ischemic stroke.

Activation of PPM1D enhances p53 function.

Gpr124 increases BBB breakdown in mouse models of ischemic stroke.


BCL-2 promotes the apoptotic effects of c-Myc.

CDK6 shows improved binding to loss-of-function variants of p18 INK4C.

Physical activity does not improve cognitive function in individuals with Alzheimers.

Rhythmic expression of Cry1 translates directly into a circadian regulation of cAMP signaling in gluconeogenesis.

Pioglitazone use is significantly associated with an increased risk of pancreatic cancer.

Urbanization is an important risk factor related to the transmission of dengue fever.

Fibroblast growth factor 21 protects against atherosclerosis by modulating adiponectin and SREBP2 levels.

32% of liver transplantation programs required patients to discontinue methadone treatment in 2001.

Expression of oncolytic virus antigens as peptides permits additional protection against relapse.

The deregulated and prolonged activation of monocytes improves inflammatory disease outcomes.

Distant CREs are less conserved among species.

G-CSF increases the expansion and infiltration of MDSCs into tumors.


BLM gene encodes RecQ-class DNA helicase.

There is no known interaction between Pioneer factor OCT3/4 and major chromatin remodeling factors.

Converting apoE4 to apoE3 by gene editing worsens the pathology associated with apoE4 in human iPSCderived neurons.

Increased vessel density along with a reduction in fibrosis improves the efficacy of chemotherapy treatments.

Tumor development occurs in conjunction with upregulation of pro-inflammatory cytokines.

Improvements in OER catalysts show stable activity over several hundred hours.

One in two surgical randomized controlled trials are discontinued early.

Misunderstandings between doctors and patients can lead to non-adherence.

Insulin effects appetite via ventral tegmental neurons.

The G34R/V mutation creates a hypomethylated phenotype at the H3K36 histone.

Dexamethasone increases risk of postoperative bleeding.

The PPR MDA5 has twenty N-terminal CARD domains.

RAD52 is involved in break-induced DNA replication (BIR).

ScPif1p has higher binding ability to G-rich ssDNA than to non-G-rich ssDNA.

ScPif1p has reduced binding ability to G-rich ssDNA compared to non-G-rich ssDNA.

R2D2 stops miRNA production by increasing the selectivity of Dcr2 for long dsRNA.

The predominant localization of Linc00173 is in mononuclear macrophage nuclei.


BRCA 1 mutation carriers' risk of breast and ovarian cancer depends on where the mutation is located.

Cancer cells can stimulate the accumulation of intra-tumoural myeloid-derived suppressor cells by promoting granulocyte colony stimulating factor production.

The mean suicide rate in women is lower after miscarriage than live birth.

90% of patients with melanoma and an objective response to PD-1 blockade will experience a progression in their melanoma.

Destination container port throughput(CPT) is negatively related to dengue virus (DENV-1) diffusion in air traffic shipments.

Monoclonal antibody targeting of N-cadherin encourages castration resistance.

Treatment with a protein named FN restores regenerative abilities of aged muscles.

Egr2 regulates the homeostasis of B and T cells.

Ten percent (10%) of kidney cancers in the UK are attributable to excess weight.

The risk of breast cancer among parous women decreases with placental weight of pregnancies.

ALDH1 expression is associated with poorer prognosis for breast cancer primary tumors.

Carriers of HNF4A mutations are at reduced risk for diabetes.

Birth-weight is negatively associated with breast cancer.

Women with a lower birth weight are more likely to develop breast cancer later in life.

Environmental factors can influence the development of breast cancer.

HNF4A mutations are associated with macrosomia in infancy.

In breast cancer, the loss of myoepithelial cells slows the transition of ductal carcinoma in situ to invasive carcinoma.


Bacterial meningitis can be diagnosed on the basis of positive cerebrospinal fluid (CSF) cultures.

The morphology change from large white adipocytes to small brown adipocytes is a sign of decreased energy expenditure potential in white adipose tissue.

Mice defective for deoxyribonucleic acid (DNA) polymerase m (polm) reveal increased sensitivity to ionizing radiation (IR).

TRAP+ osteoclasts regulate mature osteoblast maintenance.

Physical activity does not improve cognitive function in individuals with Alzheimers.

Tonic signaling from the scFv induces constitutive stimulation.

Microglia are an innate immune cell type of the central nervous system.

PKG-la does not have a large impact on expression of pain hypersensitivity in PGK-la knockout mice.

Eilat virus (EILV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in nonhuman primates.

Allogeneic mechanical circulatory support is not as effective as autologous mechanical circulatory support for treating acute myocardial infarction.

Removal of H3K9me3 by ectopic expression of other H3K9 demethylases improves reprogramming efficiency in SCNT experiments.

Women are more susceptible to death due to pneumonia when compared to men.

Men are more susceptible to death due to pneumonia when compared to women.

Chlamydia trachomatis is most prevalent in the UK among sexually-experienced individuals aged 16 to 24.

A low percentage of hematopoietic progenitor cells are susceptible to HIV-1 infection ex vivo.

Tuberculosis-induced granulomas express different immune system protein signatures than the surrounding tissue.

Oat tolerant coeliac patients may have oat specific inflammatory cells in their small bowel mucosa.

Roughly 55% of women with chronic pelvic pain have no underlying pathology.

Chlamydia trachomatis is most prevalent in the UK among individuals in their 50s and 60s.

Urbanization is an important risk factor related to the transmission of dengue fever.


Bacteriophagaes MS2 and Qβ are members of the Leviviridae.

HbA1c consistently overestimates glycemic control in black individuals with Sickle cell trait (SCT).

B3-Galectin decreases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR.

Cost effectiveness evaluations based on cRCT data lack external validity.

Including pharmacists in rounding teams does not alter the incidence of adverse drug events (ADEs).

Inhibiting focal adhesion formation increases the rate at which cells convert mechanical strain into inflammation and fibrosis.

In a naive state, blocking Wingless-Int-1 secretion from mouse embryonic stem cells inhibits self-renewal of the mouse embryonic stem cells.

Human embryonic stem cells have the capacity to give rise to differentiated progeny representative of all three embryonic germ layers.

Over half of the gabonese children with Schimmelpenning-Feuerstein-Mims syndrome (SFM) had a plasma lactate of more than 5mmol/L.

The tissue surrounding the granuloma in an immune cell induces an anti-inflammatory immune response.

Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 inhibit West Nile virus replication in cortical neurons.

The PPR MDA5 has twenty N-terminal CARD domains.

Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 encourage West Nile virus replication in cortical neurons.

Commelina yellow mottle virus (ComYMV) has three typical badnavirus ORFs, capable of encoding proteins 23, 15, and 216 kD.

Cancer-associated fibroblasts (CAFs) are constituents of tumor microenvironments

Helminths interfere with immune system control of coinfections by microbial pathogens 16.

Microglia are an innate immune cell type of the peripheral nervous system.

Microglia are an innate immune cell type of the central nervous system.

Basophils promote disease development in patients with systemic lupus erythematosus (SLE).


Bariatric surgery increases rates of colorectal cancer.

Reduced phosphorylation of PP2A increases HDAC4 dephosphorylation by enhancing PP2A-HDAC4 interaction.

Broadly HIV-1 Neutralizing Antibodies (bnAb) 10EB have no affinity for phospholipids.

Increased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm.

Integrating classroom-based collaborative learning with Web-based collaborative learning offers the best class performance.

Immune responses in immune cells are geographically segregated.

Overexpressing Cnp1 N-tail variants exacerbates the temperature-sensitive growth defect of scm3-139.

Formation of N-terminal pyroglutamate by glutamine cyclase (GC) competes with NTAQ1 for Nt-Gln substrates.

miRNAs regulate a unique suite of mRNAs to maintain homeostasis in cells.

Eliminating the last sporadic cases of malaria requires considerable funding.

Increased lipolysis leads to higher P38 phosphorylation in adipose tissue.

Bariatric surgery reduces colorectal cancer.

Bariatric surgery increases rates of postmenopausal breast cancer.

Bariatric surgery reduces postmenopausal breast cancer.

Bariatric surgery leads to negative outcomes in mental health.

Bariatric surgery leads to positive outcomes in mental health.

61% of colorectal cancer patients are diagnosed with regional or distant metastases.

1-1% of colorectal cancer patients are diagnosed with regional or distant metastases.

Ten percent (10%) of kidney cancers in the UK are attributable to excess weight.

CRP is positively correlated with postoperative mortality following Coronary Artery Bypass Graft (CABG) surgery.


Bariatric surgery increases rates of postmenopausal breast cancer.

The deregulated and prolonged activation of monocytes improves inflammatory disease outcomes.

Repressing IL-18 has negative effects on atherosclerotic lesion composition and progression.

Ca2+ cycling is a UCP1-dependent thermogenic mechanism.

H4 G94P proteins induce chromatin assembly, which increases free histones.

In transgenic mice harboring green florescent protein under the control of the Sox2 promoter, more than 50 percent of the cells with green florescent colocalize with cell proliferation markers.

N348I mutations cause resistance to nevirapine.

One in two surgical randomized controlled trials are discontinued early.

Long - range chromatin interactions regulate transcription.

Metastatic colorectal cancer treated with a single agent fluoropyrimidines resulted in similar efficacy and better quality of life when compared with oxaliplatin-based chemotherapy in elderly patients.

DMS3 protein enables Pol V transcription in vivo.

Women with a lower birth weight are more likely to develop breast cancer later in life.

The risk of breast cancer among parous women decreases with placental weight of pregnancies.

Birth-weight is negatively associated with breast cancer.

In breast cancer, the loss of myoepithelial cells promotes the transition of ductal carcinoma in situ to invasive carcinoma.


Bariatric surgery leads to negative outcomes in mental health.

Anthrax spores are very difficult to dispose once they are dispersed.

Mutant mice lacking SVCT2 have severely reduced ascorbic acid levels in both brain and adrenals.

Ethanol stress increases the expression of PSP in bacteria.

Up-regulation of the p53 pathway and related molecular events speeds cancer progression.

Students who perform poorly in the early years of medical school are less likely to commit professional misconduct later in their careers.

4-PBA treatment decreases endoplasmic reticulum stress in response to general endoplasmic reticulum stress markers.

M. stadtmanae does not induce ASC speck formation in BlaER1 monocytes.

Gpr124 increases BBB breakdown in mouse models of ischemic stroke.

Epidemiological disease burden from noncommunicable diseases is more prevalent in high economic settings.

Surgical treatment is not superior to non-surgical in treating adults with displaced fractures of the proximal humerus.

Rotator cuff exercises are more effective than general exercise therapy in reducing pain and improving function of the shoulder.

General exercise therapy is more effective than rotator cuff exercises in reducing pain and improving function of the shoulder.

Roughly 55% of women with chronic pelvic pain have no underlying pathology.


Bariatric surgery leads to positive outcomes in mental health.

Increased LDL receptors plays a role in the reduction of plasma Lp(a).

The peak incidence of fractures occurs in toddlers.

Nonsteroidal antinflammatory drugs are ineffective as cancer treatments.

Mutations in G-Beta protein GNB1 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.

Monoclonal antibody targeting of N-cadherin encourages castration resistance.

p75 NTR - associated cell death executor (NADE) interacts with the p75 NTR death domain

MafA phosphorylation decreases its ubiquitination.

CRP is positively correlated with postoperative mortality following Coronary Artery Bypass Graft (CABG) surgery.

Hematopoietic Stem Cell purification reaches purity rates above 90%.

R2D2 stops miRNA production by increasing the selectivity of Dcr2 for long dsRNA.

Bariatric surgery reduces colorectal cancer.

Bariatric surgery increases rates of colorectal cancer.

Bariatric surgery reduces postmenopausal breast cancer.

Bariatric surgery increases rates of postmenopausal breast cancer.

Scapular stabilizer exercises are more effective than general exercise therapy in reducing pain and improving function of the shoulder.


Bariatric surgery reduces colorectal cancer.

Walking in traffic areas in London improves lung function in elderly adults.

Comparative transcriptome analysis identified new platelet proteins with structural features suggesting a role in platelet function.

Bone Marrow (BM) transplantation is used to treat acute myeloid leukemia (AML)

Taking anti-depresents is associated with a decrease in the Aβ level in the brain of experimental animals.

Mice defective for deoxyribonucleic acid (DNA) polymerase m (polm) fail to reveal increased sensitivity to ionizing radiation (IR).

ALDH1 expression is associated with poorer prognosis for breast cancer primary tumors.

Increased mobility of retrotransposons is assosciated with mutation and higher tumorigenesis rates.

Genes involved in pre-mRNA splicing have a significant impact on genome stability.

EG7 tumors can be killed by systemic oxaliplatin primed CD8+ T cells from the tumor-draining lymph node cells.

PrimPol degrades short DNA replication intermediates on the leading strand during DNA replication.

Bariatric surgery leads to negative outcomes in mental health.

Bariatric surgery leads to positive outcomes in mental health.

61% of colorectal cancer patients are diagnosed with regional or distant metastases.

1-1% of colorectal cancer patients are diagnosed with regional or distant metastases.

Ten percent (10%) of kidney cancers in the UK are attributable to excess weight.

Metastatic colorectal cancer treated with a single agent fluoropyrimidines resulted in similar efficacy and better quality of life when compared with oxaliplatin-based chemotherapy in elderly patients.


Bariatric surgery reduces postmenopausal breast cancer.

Increased flux of microbial products suppresses immune responses.

Excess gestational weight gain is associated with obesity-related pregnancy outcomes.

Major antigen-induced signals from the T cell receptor and secondary signals from costimulatory receptors are required for T cell activation.

Clathrin stabilizes the spindle fiber apparatus during mitosis.

Upregulation of PD1 causes the downmodulation of Satb1.

Genes regulated by Esrrb transcription factor are sensitive to Mbd3 function.

Lamins are found within the inner layer of the mitochondrial membrane of all cells.

Gpr124 suppresses BBB breakdown in mouse models of ischemic stroke.

In British Men, haplogroup I increases risk of cardiovascular disease by 50%.

Women with a lower birth weight are more likely to develop breast cancer later in life.

The risk of breast cancer among parous women decreases with placental weight of pregnancies.

In breast cancer, the loss of myoepithelial cells promotes the transition of ductal carcinoma in situ to invasive carcinoma.


Basophils promote disease development in patients with systemic lupus erythematosus (SLE).

HIV trans-activator protein (TAT) effectively transports large and small molecules across cellular membranes into larger populations of neurons.

Algerian physicians constitue the largest component of sub-Saharan Africa-trained physicians in the United States.

Phase information is useful for predicting donor-recipient matches in organ transplantation.

Urbanization is an important risk factor related to the transmission of dengue fever.

TNFAIP3 is a glioblastoma tumor enhancer.

Bariatric surgery reduces colorectal cancer.

H4 G94P proteins induce chromatin assembly, which increases free histones.

The latent infection of myeloid cells with human cytomegalovirus induces a number of changes in gene expression.

Cytosolic proteins bind to iron-responsive elements on mRNAs coding for TFRC1.

Aggravated inflammation is dependent on NLRP3 inflammasome activation.

Neutrophils produce IL-1β in response to large particles.

A T helper 2 cell (Th2) environment impedes disease development in patients with systemic lupus erythematosus (SLE).

Lipopolysaccharides have an inflammation independent effect on kidney barrier function.

Bacteriophagaes MS2 and Qβ are members of the Leviviridae.

G-CSF increases the expansion and infiltration of MDSCs into tumors.

Systemic lupus erythematosus is a risk factor for cardiovascular disease.

The tissue surrounding the granuloma in an immune cell induces an anti-inflammatory immune response.

Many transmembrane receptors transmit signals by long-range conformational changes in the association of alpha-helices across the plasma membrane.

B cells go though plasmablast differentiation and antibody production by continuous expression of EBI2.


Removal of H3K9me3 improves reprogramming efficiency in human somatic cell nuclear transfer experiments.

The NF-κB essential modulator gene prevents intestinal inflammation by inhibiting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death.

The DESMOND program demonstrates no significant impact on biochemical outcomes.

Pre-mRNAs associated with spliceosomal components are more stable than unassociated splicing substrates.

Long chain polyunsaturated fatty acids supplementation reduces wheezing and asthma.

The proportion of people with visual difficulty is two times higher in low-income countries than in high-income countries.

Pure neural progenitor cell (NPC) populations can only be obtained from cell cultures that undergo passaging, filtration, or other isolation and cell sorting methods.

Oxidative DNA damage activates STING signalling.

The PPR MDA5 has twenty N-terminal CARD domains.

mcm 5 s 2 U is required for proper decoding of NNR codons in eukaryotes.

ScPif1p has higher binding ability to G-rich ssDNA than to non-G-rich ssDNA.

CCL19 is predominantly present within dLNs.

ScPif1p has reduced binding ability to G-rich ssDNA compared to non-G-rich ssDNA.

Active caspase-11 participate in regulating phagosome-lysosome fusion.

BLM gene encodes RecQ-class DNA helicase.

Lack of FGF21 in mice increases life expectancy.


Beta-band coherence is diminished for visible stimuli over invisible stimuli.

Cancer-associated fibroblasts (CAFs) are constituents of tumor microenvironments

Therapeutics receiving accelerated approval encounter a lower frequency of post-marketing safety events

r-protein chaperones are found in complexes with their r-protein binding partners.

Physical activity does not improve cognitive function in individuals with Alzheimers.

HOXB4 is a highly expressed component of cellular secretome from fetal liver cell populations.

PKG-la does not have a large impact on expression of spinal long term potentiation in PGK-la knockout mice.

Induction of urokinase receptor signaling in podocytes causes foot process effacement and proteinuria.

MafA phosphorylation enhances its ubiquitination.

76-85% of people with severe mental disorder receive no treatment in low and middle income countries.

The proliferative capacity of neural progenitors differs across species.

Beta-band coherence is enhanced for visible stimuli over invisible stimuli.

The density of cytokine receptor bearing cells has no effect on the distance over which cytokines act.

Occipital activation levels are associated with auditory spatial performance in parietal regions of the brain.

The density of cytokine receptor bearing cells affects the distance over which cytokines act.

Taking anti-depresents is associated with a decrease in the Aβ level in the brain of experimental animals.

Varying expression levels of EBI2 affect the positioning and migration of B cells.

Lack of FGF21 in mice leads to atherosclerotic plaque formation.


Beta-band coherence is enhanced for visible stimuli over invisible stimuli.

Cellular clocks are associated with mitosis timing in NIH 3T3 cells.

Reduction of purity of cytoplasmic membranes isolated from overexpressors is indicated by stronger spots for OmpA in 2D BN-PAGE gels.

Two variants of chromosome 6q21 are associated with radiation therapy-induced second malignancies in pediatric Hodgkin lymphoma patients.

A 100g dose of chloroquine chemoprophylactic regimen results in retinal toxicity after 1 year of weekly intake.

The C-type lectin receptor (CLEC-2) rearranges the actin cytoskeleton in dendritic cells to promote efficient motility along stromal surfaces.

Rapamycin increases the concentration of triacylglycerols in fruit flies.

Sepsis related mortality has risen from 2009 to 2014.

siRNA knockdown of A20 accelerates tumor progression in an in vivo murine xenograft model.

APOE4 expression in iPSC-derived neurons results in decreased tau phosphorylation.

RTEL1 interacts with TRF2 through a C4C4 motif

Many transmembrane receptors transmit signals by long-range conformational changes in the association of alpha-helices across the plasma membrane.

Neutrophils produce IL-1β in response to large particles.

Myelin sheaths play a role in action potential propagation.


BiP is a general endoplasmic reticulum stress marker.

During the primary early antibody response activated B cells migrate toward the inner-and outer follicular areas where oxysterol accumulation is generated by stromal cells.

Pyridostatin reduces proliferation of homologous recombination - defective cells.

Anthrax spores remain deadly until affected areas are decontaminated.

Crossover hot spots are found within gene promoters in Saccharomyces cerevisiae.

ScPif1p has reduced binding ability to G-rich ssDNA compared to non-G-rich ssDNA.

Varenicline monotherapy is more effective after 26 weeks of treatment compared to combination nicotine replacement therapies with varenicline or bupropion.

A deficiency of folate increases blood levels of homocysteine.

H4 G94P proteins induce chromatin assembly, which increases free histones.

Cost effectiveness evaluations based on cRCT data lack external validity.

CHOP is a general endoplasmic reticulum stress marker.

ATF4 is a general endoplasmic reticulum stress marker.

4-PBA treatment decreases endoplasmic reticulum stress in response to general endoplasmic reticulum stress markers.

4-PBA treatment raises endoplasmic reticulum stress in response to general endoplasmic reticulum stress markers.

Ribosomal protein (RP) expression is controlled in part by stress-activated regulators.

Mice lacking Sirt1 in Sf1-expressing neurons are immune to diet-induced obesity and insulin resistance.

Mice lacking Sirt1 in Sf1-expressing neurons have increased susceptibility to diet-induced obesity and insulin resistance.

MFGE8 regulates fat absorption by binding to av-Beta3 and av-Beta5 integrins.


Binding of p53 to enhancer regions (p53BERs) regulates the activity of p53 transcription and cell cycle arrest through the production of p53-dependent eRNAs.

Cancer-associated fibroblasts (CAFs) are constituents of tumor microenvironments

Bariatric surgery reduces postmenopausal breast cancer.

FACT and other histone chaperone(s) compensate for Histone 2A (H2A)-histone 2B (H2B) dimer eviction during the histone exchange process.

B3-Galectin increases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR.

Broadly HIV-1 Neutralizing Antibodies (bnAb) 10EB have no affinity for phospholipids.

Cognitive behavioral therapy is an ineffective treatment for insomnia

Cancers that initially benefit from epidermal growth factor receptor targeted therapies later become refractory through several mechanisms.

Adult tissue-resident macrophages are seeded before birth.

Ectopic expression of Sall4, Nanog, Esrrb, and Lin28 generates induced pluripotent stem cells from mouse embryonic fibroblasts more efficiently than other factor combinations.

Activation of PPM1D enhances p53 function.

Up-regulation of the p53 pathway and related molecular events speeds cancer progression.

Activated Cdk5 regulates DNA damage-induced neuronal death.

Activated Cdk5 phosphorylates the ATM protein in response to DNA damage.

Foxp3 enables the expression of transcriptional regulators implicated in memory T cell development.

Foxp3 represses the expression of transcriptional regulators implicated in memory T cell development.

eRNAs influence is linked to senescence, aging, and carcinogenesis.

Active caspase-11 participate in regulating phagosome-lysosome fusion.

Rhythmic expression of Cry1 translates directly into a circadian regulation of cAMP signaling in gluconeogenesis.


Birth-weight is negatively associated with breast cancer.

Taking anti-depresents is associated with a decrease in the Aβ level in the brain of experimental animals.

Hypocretin neurones suppress panicprone state in rats.

The predominant localization of Linc00173 is in mononuclear macrophage nuclei.

Specialized functional cell types can be derived from human pluripotent stem cells.

Glioblastoma multiforme (GBM) is characterized by extensive invasion, rapid growth, necrosis, and angiogenesis.

Chemical injury represses transglutaminase 2 activity.

H.pylori-mediated gastric cancer occurs due to the accumulation of mutations in host epithelial cells.

Female carriers of the Apolipoprotein E4 (APOE4) allele have decreased risk for dementia.

Ethanol stress increases the expression of PSP in bacteria.

Clathrin stabilizes the spindle fiber apparatus during mitosis.

Women with a lower birth weight are more likely to develop breast cancer later in life.

The risk of breast cancer among parous women decreases with placental weight of pregnancies.

53% of perinatal mortality is due to low birth weight.

Excess gestational weight gain is associated with obesity-related pregnancy outcomes.

Vitamin D deficiency effects birth weight.

The mean suicide rate in women is lower after miscarriage than live birth.

The mean suicide rate in women is higher after miscarriage than live birth.

Ten percent (10%) of kidney cancers in the UK are attributable to excess weight.

Female carriers of the Apolipoprotein E4 (APOE4) allele have shorter lifetime exposure to estrogen due to a decreased reproductive period.


Blocking the interaction between TDP-43 and respiratory complex I proteins ND3 and ND6 prevents TDP-43-induced neuronal loss.

MeCP2 influences the synaptic maturation of neurons.

Mice defective for deoxyribonucleic acid (DNA) polymerase m (polm) fail to reveal increased sensitivity to ionizing radiation (IR).

Patients with panic anxiety show decreased CSF levels of hypocretin.

Citrullinated proteins externalized in neutrophil extracellular traps act indirectly to perpetuate the inflammatory cycle via induction of autoantibodies.

Inhibiting focal adhesion formation increases the rate at which cells convert mechanical strain into inflammation and fibrosis.

Omnivores produce less trimethylamine N-oxide from dietary I-carnitine than vegans.

Fibroblast Growth Factor is a ligand which signals through receptor tyrosine kinases.

ScPif1p has reduced binding ability to G-rich ssDNA compared to non-G-rich ssDNA.

MafA phosphorylation enhances its ubiquitination.

The NF-κB essential modulator gene prevents intestinal inflammation by inhibiting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death.

ITAM phosphorylation allows for the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).

Foxp3 enables the expression of transcriptional regulators implicated in memory T cell development.

Reduced responsiveness to interleukin-2 in regulatory T cells is associated with autoimmune diseases such as Type 1 Diabetes.

Gpr124 suppresses BBB breakdown in mouse models of ischemic stroke.

IL-10 production by monocytes inhibits CD4 + T cell response.

Certain immunomodulator-human dialyzable leukocyte extract (hDLE) peptides are recognized by toll-like receptors (TLRs) on macrophages and dendritic cells.

Gpr124 increases BBB breakdown in mouse models of ischemic stroke.

B3-Galectin decreases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR.


Bone Marrow (BM) transplantation is used to treat acute myeloid leukemia (AML)

Walking in traffic areas in London improves lung function in elderly adults.

Individuals with Alzheimers who participate in six months of physical activity improve cognitive function for up to 18 months.

Diabetic patients with acute coronary syndrome experience decreased short-term and long-term risk for bleeding events.

Human embryonic stem cells give rise to cell types from the outer embryonic germ layer, but not the other two layers.

Neutrophils produce IL-1β in response to large particles.

DMS3 protein enables Pol V transcription in vivo.

Primary cervical cancer screening with HPV detection has lower longitudinal sensitivity than conventional cytology to detect cervical intraepithelial neoplasia grade 2.

Cardiac tissue-resident macrophages directly contribute to electrical activity.

A country's Vaccine Alliance (GAVI) eligibility is not indictivate of accelerated adoption of the Hub vaccine.

PKG-la does not have a large impact on expression of pain hypersensitivity in PGK-la knockout mice.

Glioblastoma multiforme (GBM) is characterized by extensive invasion, rapid growth, necrosis, and angiogenesis.

The latent infection of myeloid cells with human cytomegalovirus induces a number of changes in gene expression.

Approximately 250,000 people are infected with human T-cell lymphotropic virus type 1 in the United Kingdom.

Klf2 is important for proper myeloid cell function.

Chronic HIV stimulation of B cells leads to the premature exhaustion of B cells.

Bone marrow cells don't contribute to adult macrophage compartments.

Klf4 is not required for proper myeloid cell differentiation.

Cancer-associated fibroblasts (CAFs) are constituents of tumor microenvironments

Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes fibrosis.


Bone marrow cells don't contribute to adult macrophage compartments.

The DdrB protein from Deinococcus radiodurans functions as a pentamer.

Binding of p53 to enhancer regions (p53BERs) regulates the activity of p53 transcription and cell cycle arrest through the production of p53-dependent eRNAs.

Higher plasma levels of I-carnitine, when associated with trimethylamine N-oxide, are negatively correlated with cardiovascular events in humans.

Tonic signaling from the scFv prevents constitutive stimulation.

Antidepressants reduce the severity of migraines.

Retinoic acid receptor-related orphan receptor gamma (RORγ) is a therapeutic target for castration-resistant prostate cancer (CRPC)

Female carriers of the Apolipoprotein E4 (APOE4) allele have decreased risk for dementia.

Addition of BMP4, activin A, CHIR99021, and SU504 to reprogramming fibroblasts generates, expands and maintains cardiovascular progenitor cells (CPCs)

Eliminating the last sporadic cases of malaria requires considerable funding.

Overexpressing Cnp1 N-tail variants exacerbates the temperature-sensitive growth defect of scm3-139.

Adult tissue-resident macrophages stem from the embryonal yolk sac and fetal liver.

Adult tissue-resident macrophages possess a self-renewing capacity.

Adult tissue-resident macrophages are seeded before birth.

Cardiac tissue-resident macrophages directly contribute to electrical activity.

Differentiation of progenitor cells to myeloid cells is skewed upon activation of insulin signaling.

Human embryonic stem cells give rise to cell types from the outer embryonic germ layer, but not the other two layers.

Differentiation of progenitor cells to myeloid cells is skewed when insulin signaling is suppressed.


British female students are bullied more than British male students.

Misunderstandings between doctors and patients can lead to non-adherence.

Patients in stable partnerships have a slower progression from HIV to AIDS.

The morphology change from large white adipocytes to small brown adipocytes is a sign of increased energy expenditure potential in white adipose tissue.

The repeat-variable diresidue (RVD) in the loop of Transcription-Activator Like (TAL) effectors specifies the nucleotides-amino acid contact at the target promoter element.

Distant CREs are important for transcriptional regulation.

Decreased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm.

In young and middle-aged adults, current or remote uses of ADHD medications increase the risk of serious cardiovascular events.

Guanine nucleotide exchange factors (GEFs) mediate RhoA activation in response to tensional forces on fibronectin-binding integrins.

Nonsteroidal antinflammatory drugs show potential anticancer indications.

Rapamycin increases the concentration of triacylglycerols in fruit flies.

British male students are bullied more than British female students.

The risk of female prisoners harming themselves is ten times that of male prisoners.

In the UK, drowning affects boys and girls equally.

The mean suicide rate in women is higher after miscarriage than live birth.

The mean suicide rate in women is lower after miscarriage than live birth.

Women with a lower birth weight are more likely to develop breast cancer later in life.

Chlamydia trachomatis is most prevalent in the UK among sexually-experienced individuals aged 16 to 24.

Students who perform poorly in the early years of medical school are at increased risk for professional misconduct later in their careers.

Students who perform poorly in the early years of medical school are less likely to commit professional misconduct later in their careers.


British male students are bullied more than British female students.

Recognition of start codons depends on the translation initiation factor IF3.

Alirocumab treatment reduces apo(a) fractional clearance rate.

Reduction of Rpl38 alters the composition of the Hox gene mRNAs translation in mice without lowering overall protein synthesis.

Folate and vitamin B12 levels influence the association between homocysteine and preeclampsia.

p75 NTR - associated cell death executor (NADE) interacts with the p75 NTR death domain

90% of patients with melanoma and an objective response to PD-1 blockade will experience a progression in their melanoma.

Low nucleosome occupancy correlates with high methylation levels across species.

Pre-mRNAs associated with spliceosomal components are less stable than unassociated splicing substrates.

61% of colorectal cancer patients are diagnosed with regional or distant metastases.


Broadly HIV-1 Neutralizing Antibodies (bnAb) 10EB have no affinity for phospholipids.

LSD1-positive promoters are associated with RNA polymerase II

Women are more susceptible to death due to pneumonia when compared to men.

Increased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm.

De novo assembly of sequence data has fewer specific contigs than unassembled sequence data.

Bariatric surgery increases rates of colorectal cancer.

Ca2+ cycling is a UCP1-dependent thermogenic mechanism.

Increased microtubule acetylation repairs interference of axonal transport caused by LRRK2 Roc-COR domain mutations.

Upon viral challenge, influenza-specific memory CD4+ T cells greatly enhance the early production of inflammatory chemokines in the lung.

Rising temperatures caused by global warming lowers the risk of dengue fever transmission.

Mutations in G-Beta protein GNB1 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.

Microcin J25 inhibits nucleoside triphosphate (NTP) binding.

Gpr124 increases BBB breakdown in mouse models of ischemic stroke.

Microcin J25 encourages nucleoside triphosphate (NTP) binding.

ScPif1p has higher binding ability to G-rich ssDNA than to non-G-rich ssDNA.

Gpr124 suppresses BBB breakdown in mouse models of ischemic stroke.

The DdrB protein from Deinococcus radiodurans functions as a pentamer.

ScPif1p has reduced binding ability to G-rich ssDNA compared to non-G-rich ssDNA.


C2 works synergistically with A-769662 to activate dephosphorylated AMPK.

The first MBT repeat of the four malignant brain tumor (4MBT) domain of Drosophila's Sfmbt and of the orthologous mammalian L3MBTL2 is required for the interaction with the spacer region of Drosophila's Pleiohomeotic (Pho) or its human ortholog YY1.

Walking in traffic areas in London did not improve lung function in elderly adults.

Oxidative DNA damage inhibits STING signalling.

Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection increases dissemination of Salmonella Typhimurium from the gut.

A diminished ovarian reserve is a very strong indicator of infertility, even in an a priori non-infertile population.

Physical activity does not improve cognitive function in individuals with Alzheimers.

High levels of CRP lead to a higher risk of exacerbations in chronic obstructive pulmonary disease (COPD).

MT binding domain drives amyloid structure formation.

Integrated care is ineffective at tackling multiple comorbidities.

Reduced phosphorylation of PP2A increases HDAC4 dephosphorylation by enhancing PP2A-HDAC4 interaction.

ITAM phosphorylation allows for the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).

Reduced phosphorylation of PP2A suppresses HDAC4 dephosphorylation.

Inhibiting glucose-6-phospate dehydrogenase improves lipogenesis by deactivating LKB1-AMPK signaling.

AMP-activated protein kinase (AMPK) activation reduces inflammation-related fibrosis in the lungs.

Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes fibrosis.

Removal of H3K9me3 by ectopic expression of other H3K9 demethylases improves reprogramming efficiency in SCNT experiments.

B3-Galectin increases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR.

B3-Galectin decreases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR.


Forkhead 0 (fox0) transcription factors are involved in cellular differentiation.

Natriuretic peptides increase susceptibility to diabetes.

Inhibiting focal adhesion formation enables cells to convert mechanical strain into eventual scarring.

Cancer-associated fibroblasts (CAFs) have no known interaction with cancer cells in the formation and activation of CAFs.

Ribosomal protein (RP) expression is controlled in part by stress-activated regulators.

Mutant mice lacking SVCT2 have severely reduced ascorbic acid levels in both brain and adrenals.

Lamins are associated with nuclear membrane structure maintenance.

76-85% of people with severe mental disorder receive no treatment in low and middle income countries.

Ca2+ cycling is a UCP1-dependent thermogenic mechanism.

In the UK, drowning affects boys and girls equally.

CCL19 is predominantly present within dLNs.

L3MBTL2 binds to H2AK119Ub marked chromatin to form a PRC1 complex.

The PPR MDA5 has twenty N-terminal CARD domains.

The PDPN gene deactivates the C-type lectin receptor (CLEC-2).

The predominant localization of Linc00173 is in mononuclear macrophage nuclei.


CCL19 is predominantly present within dLNs.

Carriers of HNF4A mutations are at reduced risk for diabetes.

Reduction of Rpl38 alters the composition of the Hox gene mRNAs translation in mice without lowering overall protein synthesis.

Cancer cells can stimulate the accumulation of intra-tumoural myeloid-derived suppressor cells by promoting granulocyte colony stimulating factor production.

Ultrasound guidance significantly reduces the number of needle insertion attempts necessary for a given procedure.

The morphology change from large white adipocytes to small brown adipocytes is a sign of increased energy expenditure potential in white adipose tissue.

There was an estimated 30 million cases of pneumonia in young children worldwide in 2010.

Major vault protein (MVP) leads to more aggressive tumors by regulating the sorting of tumor suppressive miR-193a into extracellular vesicles (EVs).

Propriospinal interneurons that play a role in the plastic reorganization of spinal circuits are integral for recovery from spinal cord injury.

Oxidative DNA damage activates STING signalling.

Cis-acting lncRNAs control the expression of genes that are positioned in the vicinity of their transcription sites.

CDK6 shows improved binding to loss-of-function variants of p18 INK4C.

Sn is present on mature DCs during inflammation in vivo.


CD28 initiates tonic signaling in conventional T cells, which causes an exhaustion phenotype and limited efficiency.

Sweet taste receptors on the tongue are deactivated by between 1 and 10 mM glucose.

Active H. pylori urease has a polymeric structure consisting of five distinct subunits.

1-1% of colorectal cancer patients are diagnosed with regional or distant metastases.

Excess gestational weight gain is associated with obesity-related pregnancy outcomes.

Tumor development occurs in conjunction with upregulation of pro-inflammatory cytokines.

Cardiac tissue-resident macrophages directly contribute to electrical activity.

Ca2+ cycling controls whole-body energy homeostasis in beige fat.

The cytokine receptor which regulates chemotaxis and formation of lymph nodes is involved in production of myeloperoxidase in the left atrium.

Many cytokines that are produced by cancer cells also contribute to carcinogenesis.

De novo assembly of sequence data has fewer specific contigs than unassembled sequence data.

CD28 signals regulate trafficking of murine auto-reactive T cells into target tissues.

Major antigen-induced signals from the T cell receptor and secondary signals from costimulatory receptors are required for T cell activation.

IL-10 production by monocytes inhibits CD4 + T cell response.

Type 1 Diabetes is associated with subtle perturbations in T reg development.

Peroxynitrite is required for induction of T cell tolerance.

ITAM phosphorylation allows for the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).

Activated Cdk5 phosphorylates the ATM protein in response to DNA damage.

Reduced responsiveness to interleukin-2 in regulatory T cells is associated with autoimmune diseases such as Type 1 Diabetes.

Activated Cdk5 regulates DNA damage-induced neuronal death.


CD28 signals regulate trafficking of murine auto-reactive T cells into target tissues.

Upregulation of PD1 causes the downmodulation of Satb1.

Monoclonal antibody targeting of N-cadherin inhibits growth.

Urbanization is an important risk factor related to the transmission of dengue fever.

Persistor cells are one reason for incomplete responses to Tyrosine kinase inhibitor (TKI) therapy in cancer patients.

DRD1 proteins enable Pol V transcription in vivo.

Mutations in G-Beta protein GNB1 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.

Roughly 55% of women with chronic pelvic pain have no underlying pathology.

The innate immune response struggles to remove small numbers of parasites.

Stroke patients with prior use of direct oral anticoagulants have a higher risk of in-hospital mortality than stroke patients with prior use of warfarin.

HOXB4 is a highly expressed component of cellular secretome from fetal liver cell populations.

T cell receptor /CD3 microdomains are required to induce the immunologic synapse.

Foxp3 represses the expression of transcriptional regulators implicated in memory T cell development.

Foxp3 enables the expression of transcriptional regulators implicated in memory T cell development.


CD44v6 is not associated with constitutive and reprogrammed cancer stem cells driving cancer metastasis.

Cognitive behavioral therapy is an ineffective treatment for insomnia

MICAL redox enzymes regulate actin dynamics.

Monoclonal antibody targeting of N-cadherin encourages castration resistance.

B3-Galectin decreases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR.

Systemic immunosuppressive (IS) therapy increases the chance of cancer mortality in patients with inflammatory eye disease (IED)

The PRDM1 gene, when combined with the PRDM14 gene, plays an important role during primordial germ cell specification.

Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes epithelial damage.

Mice lacking Sirt1 in Sf1-expressing neurons have increased susceptibility to diet-induced obesity and insulin resistance.

Inhibiting glucose-6-phospate dehydrogenase improves lipogenesis by deactivating LKB1-AMPK signaling.

CDK6 shows impaired binding to loss-of-function variants of p18 INK4C.

p16INK4A degradation is encoded by CDKN2A.

CDK6 shows improved binding to loss-of-function variants of p18 INK4C.

MEK inhibitors are effective treatments in RAS-driven mouse models of cancer.

ALDH1 expression is associated with poorer prognosis for breast cancer primary tumors.

Cancer-associated fibroblasts (CAFs) have no known interaction with cancer cells in the formation and activation of CAFs.

GATA3 regulates self-renewal capacity in bone marrow hematopoietic stem cells.


CDK6 shows impaired binding to loss-of-function variants of p18 INK4C.

Homozygous deletion of murine Sbds gene from osterix-expressing mesenchymal stem and progenitor cells (MPCs) induces oxidative stress.

T cell receptor /CD3 microdomains are required to induce the immunologic synapse.

Gpr124 increases BBB breakdown in mouse models of ischemic stroke.

Pseudogene PTENP1 encodes a transcript that regulates PTEN expression.

The microtubule-dependent delivery and secretion of matrix metalloproteases (MMPs) is partially responsible for the disassembly of adhesion sites.

Moderate consumption of candy and chocolate reduces the risk of cardiovascular disease (CVD).

M. stadtmanae induces ASC speck formation in BlaER1 monocytes.

British male students are bullied more than British female students.

PrimPol degrades short DNA replication intermediates on the leading strand during DNA replication.

Forkhead 0 (fox0) transcription factors are involved in apoptosis.

p16INK4A degradation is  linked to an abnormal wound response caused by the microinvasive step of advanced Oral Potentially Malignant Lesions (OPMLs).

Reduced phosphorylation of PP2A increases HDAC4 dephosphorylation by enhancing PP2A-HDAC4 interaction.

Reduced phosphorylation of PP2A suppresses HDAC4 dephosphorylation.

Gpr124 suppresses BBB breakdown in mouse models of ischemic stroke.

The PPR MDA5 has twenty N-terminal CARD domains.


CDK6 shows improved binding to loss-of-function variants of p18 INK4C.

GATA3 regulates cell cycle progression in bone marrow hematopoietic stem cells.

Pioglitazone use is significantly associated with an increased risk of prostate cancer.

In the UK, drowning affects boys and girls equally.

H4 G94P proteins suppress degradation of free histones via Rad53-dependent mechanisms.

Many transmembrane receptors transmit signals by long-range conformational changes in the association of alpha-helices across the plasma membrane.

Normal granulomas form in the presence of TNF in Zebrafish.

Algerian physicians constitue the largest component of sub-Saharan Africa-trained physicians in the United States.

Environmentally-induced senescence is mimicked in disease modeling by adding specific molecules to the culture system.

Antidepressants increase the severity of migraines.

The G34R/V mutation does not create a hypomethylated phenotype at the H3K36 histone.

Activated Cdk5 phosphorylates the ATM protein in response to DNA damage.


CHOP is a general endoplasmic reticulum stress marker.

Tonic signaling from the scFv prevents constitutive stimulation.

Physical activity does not improve cognitive function in individuals with Alzheimers.

The HSV-2 infection is typically asymptomatic.

Increase of p62 in prostate tumor stroma results in defective autophagy.

Mutant mice lacking SVCT2 have severely reduced ascorbic acid levels in both brain and adrenals.

The deregulated and prolonged activation of monocytes improves inflammatory disease outcomes.

Cancer-associated fibroblasts (CAFs) are constituents of tumor microenvironments

Mice lacking Sirt1 in Sf1-expressing neurons have increased susceptibility to diet-induced obesity and insulin resistance.

R2D2 stops miRNA production by increasing the selectivity of Dcr2 for long dsRNA.

Reduction of purity of cytoplasmic membranes isolated from overexpressors is indicated by stronger spots for OmpF in 2D BN-PAGE gels.

BiP is a general endoplasmic reticulum stress marker.

ATF4 is a general endoplasmic reticulum stress marker.

4-PBA treatment decreases endoplasmic reticulum stress in response to general endoplasmic reticulum stress markers.

4-PBA treatment raises endoplasmic reticulum stress in response to general endoplasmic reticulum stress markers.

Ribosomal protein (RP) expression is controlled in part by stress-activated regulators.

The Snf1 complex regulates carbon and energy metabolism in baker's yeast (Saccharomyces cerevisiae).

EGR2 is important to myelination of the peripheral nervous system.

Activation of PPM1D enhances p53 function.

Binding of p53 to enhancer regions (p53BERs) regulates the activity of p53 transcription and cell cycle arrest through the production of p53-dependent eRNAs.