Sn is present on mature DCs during inflammation in vivo.

Cholesterol loading induces KLF4 expression in VSMCs, resulting in the expression of pro-inflammatory cytokines.

NR5A2 is important in reverse cholesterol transport in humans.

Monoclonal antibody targeting of N-cadherin inhibits growth.

The most prevalent adverse events to Semaglutide are cardiovascular.

Sympathetic nerve activity is elevated throughout normal pregnancy.

The deregulated and prolonged activation of monocytes improves inflammatory disease outcomes.

TNFAIP3 is a glioblastoma tumor suppressor.

Increase of p62 in prostate tumor stroma results in defective autophagy.

Expression of oncolytic virus antigens as peptides permits additional protection against relapse.

Foxp3 represses the expression of transcriptional regulators implicated in memory T cell development.

R2D2 stops miRNA production by increasing the selectivity of Dcr2 for long dsRNA.

CCL19 is predominantly present within dLNs.

Peroxynitrite is required for induction of T cell tolerance.

N348I mutations cause resistance to nevirapine.

N348I mutations reduce resistance to nevirapine.

NAC destabilizes NO to increase the effect of contrast agents on renal functions.

KLF4 is necessary for VSMCs to gain genetic characteristics of other cell types within atherosclerotic lesions.

The HSV-2 infection is typically asymptomatic.


Specialized functional cell types can be derived from human pluripotent stem cells.

The myocardial cell lineage originally develops from cardiac progenitors of exclusively endodermal origin.

Long chain polyunsaturated fatty acids supplementation reduces wheezing and asthma.

Lack of FGF21 in mice leads to reduced lifespan.

Increased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm.

Treatment with a protein named FN impairs regenerative abilities of aged muscles.

ERAP1 SNPs are epistatic to HLA alleles for ankylosing spondylitis.

Exhaustion of B cells contributes to poor Ab response in HIV-infected individuals.

Pro-inflammatory cytokines are up regulated during tumor development.

A mutation in HNF4A leads to an increased risk of diabetes by the age of 14 years.

Human embryonic stem cells give rise to cell types from all three embryonic germ layers.

Human embryonic stem cells have the capacity to give rise to differentiated progeny representative of all three embryonic germ layers.

Human embryonic stem cells give rise to cell types from the outer embryonic germ layer, but not the other two layers.

Androgenetic haploid mouse embryonic stem cells (ESCs) can be derived and genetically manipulated in vitro.

Transplanted human glial progenitor cells can mature in their host animal.

Adult tissue-resident macrophages stem from the embryonal yolk sac and fetal liver.

Bone marrow cells don't contribute to adult macrophage compartments.

The proliferative capacity of progenitors is regulated cell-autonomously.


Splenomegaly is observed in knockin mouse lacking the SHP-2 MAPK pathway.

Guanine nucleotide exchange factors (GEFs) mediate RhoA activation in response to tensional forces on fibronectin-binding integrins.

Measuring routine outcomes is more beneficial to clinical practice than assessing treatment adherence.

N348I mutations reduce resistance to nevirapine.

Reduction of Rpl38 alters the composition of the Hox gene mRNAs translation in mice without lowering overall protein synthesis.

LSD1-positive promoters are associated with RNA polymerase II

Asymptomatic visual impairment screening in elderly populations leads to improved vision.

Broadly HIV-1 Neutralizing Antibodies (bnAb) 10EB have no affinity for phospholipids.

The G34R/V mutation does not create a hypomethylated phenotype at the H3K36 histone.

Thiopurine active metabolites can be catabolized through dephosphorylation of thioguanine nucleotides.

Up-regulation of the p53 pathway and related molecular events speeds cancer progression.

MUC1-C activates the NF-κB p65 signaling pathway by interacting with IκB kinase ß.

Foxk2 regulates autophagy genes in muscle cells and fibroblast cells.

The minor G allele of FOXO3 up-regulates IL-10.

Foxp3 represses the expression of transcriptional regulators implicated in memory T cell development.

Foxp3 enables the expression of transcriptional regulators implicated in memory T cell development.

The minor G allele of FOXO3 downregulates pro-inflammatory cytokines.

FoxO3a activation in neuronal death is inhibited by reactive oxygen species (ROS).

Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes epithelial damage.

Reducing H3k4me3 methylation induces mouse epiblast stem cells to naive pluripotency efficiently.


Stacking is more stable when a purine is present in the +5 position (C1698).

4-PBA treatment raises endoplasmic reticulum stress in response to general endoplasmic reticulum stress markers.

Activated Cdk5 phosphorylates the ATM protein in response to DNA damage.

Bone Marrow (BM) transplantation is used to treat acute myeloid leukemia (AML)

Decreased conversion of PGE 2 to PPARy ligand 15-ket-PGE 2 causes accumulation of PGE.

Ly49Q directs the organization of neutrophil polarization by regulating membrane raft functions.

Bariatric surgery increases rates of colorectal cancer.

Tonic signaling from the scFv is amplified by MyD88/CD40.

Taking anti-depresents is associated with a decrease in the Aβ level in the brain of experimental animals.

Sweet taste receptors on the tongue are deactivated by between 1 and 10 mM glucose.

Hypocretin neurones suppress panicprone state in rats.

mcm 5 s 2 U is required for proper decoding of NNR codons in eukaryotes.

The recruitment of Wdr5 to its target loci depends on Kat8.

Recognition of start codons depends on the translation initiation factor IF3.

During non-homologous end joining, the ligation step is not as tolerant of disrepairs and other distortions when joining 5' of strand breaks as compared to 3' strand breaks.

During non-homologous end joining, the ligation step is not as tolerant of disrepairs and other distortions when joining 3' of strand breaks as compared to 5' strand breaks.

Replacement of histone H2A with H2A.Z accelerates gene activation in yeasts by destabilizing +1 nucleosomes.

The H2A-H2B eviction defect is compensated for by other histone chaperone(s).

r-protein chaperones are found in complexes with their r-protein binding partners.

JMJD6 slows the hydroxylation of C-terminal lysine


Stiff substrates encourage mesodermal differentiation by degrading beta-catenin in an integrin-dependent manner.

Increased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm.

Students who perform poorly in the early years of medical school are at increased risk for professional misconduct later in their careers.

Individuals with Alzheimers who participate in six months of physical activity improve cognitive function for up to 18 months.

IL-10 production by monocytes inhibits CD4 + T cell response.

Human embryonic stem cells give rise to cell types from all three embryonic germ layers.

Commelina yellow mottle virus (ComYMV) has three typical badnavirus ORFs, capable of encoding proteins 23, 15, and 216 kD.

HIV trans-activator protein (TAT) effectively transports large and small molecules across cellular membranes into larger populations of neurons.

Bone marrow cells don't contribute to adult macrophage compartments.

Chinese individuals with TT homozygosity in the MTHFR gene are more vulnerable to strokes caused by low levels of folate intake.

Asymptomatic visual impairment screening in elderly populations leads to improved vision.

Stiff substrates inhibit mesodermal differentiation by degrading beta-catenin in an integrin-dependent manner.

Intramembrane cleavage by signal peptide peptidase aids in the degradation of proteins with a complex membrane orientation.

β-sheet opening occurs during pleurotolysin pore formation.

Upregulation of dynein in Drosophila neurons increases the number of microtubule plus-ends growing toward the cell body of each neuron.

Myelin sheaths are lipid-rich cellular structures.

PRC1-bound plasmids sediment at a slower rate in unbound plasmids than in sucrose gradients.

Differentiation of progenitor cells to myeloid cells is skewed when insulin signaling is suppressed.

Pre-mRNAs associated with spliceosomal components are less stable than unassociated splicing substrates.

Venules have less significant tunica adventitia than arterioles.


Stiff substrates inhibit mesodermal differentiation by degrading beta-catenin in an integrin-dependent manner.

IgA plasma cells that are specific for transglutaminase 2 are scarce in the duodenal mucosa of celiac disease patients when the disease is active.

Inhibiting HDAC6 increases survival of mice with ARID1A mutated tumors.

De novo assembly of sequence data has shorter contigs than unassembled sequence data.

Drosophila supracellular actomyosin structures are found at boundaries in wing imaginal discs.

Activation of the Rac1 homolog CED-10 kills viable cells in SRGP-1 mutant Caenorhabditis elegans.

Dexamethasone increases risk of postoperative bleeding.

There is a relation between Erythromycin use and hypertrophic pyloric stenosis.

The tissue surrounding the granuloma in an immune cell induces an anti-inflammatory immune response.

Mouse models can be generated using "artificial spermatids."

Formation of N-terminal pyroglutamate by glutamine cyclase (GC) competes with NTAQ1 for Nt-Gln substrates.

The microtubule-dependent delivery and secretion of matrix metalloproteases (MMPs) is partially responsible for the disassembly of adhesion sites.

Inhibiting focal adhesion formation increases the rate at which cells convert mechanical strain into inflammation and fibrosis.


Stroke patients with prior use of direct oral anticoagulants have a higher risk of in-hospital mortality than stroke patients with prior use of warfarin.

Omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegetarians.

Pseudogene PTENP1 encodes a transcript that regulates PTEN expression.

Low expression of miR7a does not repress target genes or exert a biological function in testis.

1 in 5 million in UK have abnormal PrP positivity.

De novo assembly of sequence data has fewer specific contigs than unassembled sequence data.

Insulin effects appetite via ventral tegmental neurons.

Bariatric surgery increases rates of colorectal cancer.

Combination nicotine replacement therapies with varenicline or bupropion are more effective after 12 weeks of reatment compared to varenicline monotherapy.

Androgenetic haploid mouse embryonic stem cells (ESCs) can be derived and genetically manipulated in vitro.

Activated Cdk5 phosphorylates the ATM protein in response to DNA damage.

Side effects associated with antidepressants increases risk of stroke.

Side effects associated with antidepressants do not represent a mortality risk to postmenopausal women.

Side effects associated with antidepressants lower risk of myocardial infarction.

Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission.

Dexamethasone increases risk of postoperative bleeding.

Systemic immunosuppressive (IS) therapy increases the chance of cancer mortality in patients with inflammatory eye disease (IED)

Varenicline monotherapy is more effective after 26 weeks of treatment compared to combination nicotine replacement therapies with varenicline or bupropion.

Antidepressants reduce the severity of migraines.

Systemic immunosuppressive (IS) therapy does not enhance the chance of cancer mortality in patients with inflammatory eye disease (IED)


Students who perform poorly in the early years of medical school are at increased risk for professional misconduct later in their careers.

MICAL redox enzymes regulate actin dynamics.

One in two surgical randomized controlled trials are discontinued early.

The risk of cancer rises with level of alcohol consumption.

CDK6 shows improved binding to loss-of-function variants of p18 INK4C.

Glucose restriction to 0.05% reduces RLS (replicative life span) by 20-40% in S. cerevisiae.

The latent infection of myeloid cells with human cytomegalovirus induces a number of changes in gene expression.

Bariatric surgery leads to positive outcomes in mental health.

Overexpressing Cnp1 N-tail variants exacerbates the temperature-sensitive growth defect of scm3-139.

Environmentally-induced senescence is mimicked in disease modeling by adding specific molecules to the culture system.

Students who perform poorly in the early years of medical school are less likely to commit professional misconduct later in their careers.

Misunderstandings between doctors and patients can lead to non-adherence.

Risk-adjusted mortality rates are similar in teaching and non-teaching hospitals.

Nigerian physicians constitue the largest component of sub-Saharan Africa-trained physicians in the United States.

Assessing treatment adherence is more beneficial to clinical practice than measuring routine outcomes.

Measuring routine outcomes is more beneficial to clinical practice than assessing treatment adherence.

In young and middle-aged adults, current or remote uses of ADHD medications increase the risk of serious cardiovascular events.

Algerian physicians constitue the largest component of sub-Saharan Africa-trained physicians in the United States.


Students who perform poorly in the early years of medical school are less likely to commit professional misconduct later in their careers.

Radioiodine treatment of non-toxic multinodular goitre increases thyroid volume.

Lamins are associated with nuclear membrane structure maintenance.

Integrating classroom-based collaborative learning with Web-based collaborative learning offers the best class performance.

LSD1-positive promoters are associated with RNA polymerase II

RTEL1 interacts with TRF2 through a C4C4 motif

Fibroblast Growth Factor is a ligand which signals through receptor tyrosine kinases.

Long - range chromatin interactions regulate transcription.

Medications to treat obesity have unwanted side effects.

Diabetic patients with acute coronary syndrome experience decreased short-term and long-term risk for bleeding events.

Side effects associated with antidepressants do not represent a mortality risk to postmenopausal women.


Suboptimal nutrition is a leading cause of premature death

70% of burn patients are admitted for hospitalization and further treatment after appearing at hospital emergency wards or outpatient clinics.

Clathrin stabilizes the spindle fiber apparatus during mitosis.

The morphology change from large white adipocytes to small brown adipocytes is a sign of decreased energy expenditure potential in white adipose tissue.

Consumption of whole fruits increases the risk of type 2 diabetes.

Blocking the interaction between TDP-43 and respiratory complex I proteins ND3 and ND6 prevents TDP-43-induced neuronal loss.

Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 inhibit West Nile virus replication in cortical neurons.

Sepsis related mortality has risen from 2009 to 2014.

There is a positive correlation between hip fractures and statin use.

A diminished ovarian reserve is a very strong indicator of infertility, even in an a priori non-infertile population.

Replacement of histone H2A with H2A.Z accelerates gene activation in yeasts by destabilizing +1 nucleosomes.

53% of perinatal mortality is due to low birth weight.

10% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.

90% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.

The mean suicide rate in women is higher after miscarriage than live birth.

Epidemiological disease burden from noncommunicable diseases is more prevalent in high economic settings.

The mean suicide rate in women is lower after miscarriage than live birth.

Autophagy deficiency in the liver increases vulnerability to insulin resistance.

Elevated cell-free mitochondrial DNA levels are associated with mortality.


Sudden death can occur in patients with complex ventricular arrhythmias.

Having a main partner improves HIV outcomes.

Mutations in RIM1 raise levels of IME1 RNA.

Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection increases dissemination of Salmonella Typhimurium from the gut.

Normal granulomas form in the absence of TNF in Zebrafish.

The DdrB protein from Deinococcus radiodurans functions as a pentamer.

Nonsteroidal antinflammatory drugs are ineffective as cancer treatments.

Approximately 250,000 people are infected with human T-cell lymphotropic virus type 1 in the United Kingdom.

TRAP+ osteoclasts regulate mature osteoblast maintenance.

Sudden death can occur in patients with orthostatic hypertension without cardiac conduction abnormalities.

Decreased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm.

Diabetic patients with acute coronary syndrome experience decreased short-term and long-term risk for bleeding events.

Increased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm.

Noninvasive positive pressure ventilation is not predictive of acute respiratory failure after solid organ transplantation.

Migraine with aura is associated with ischemic stroke.

Allogeneic mechanical circulatory support is not as effective as autologous mechanical circulatory support for treating acute myocardial infarction.


Sudden death can occur in patients with orthostatic hypertension without cardiac conduction abnormalities.

Immune complex triggered cell death leads to extracellular release of nuclear DNA.

Osteocytes have an essential role in G-CSF induced HSPC mobilization.

Comparative transcriptome analysis identified new platelet proteins with structural features suggesting a role in platelet function.

0-dimensional biomaterials lack inductive properties.

Interleukin-18 plays an important role in the pathogenesis of atherosclerosis.

Mice lacking Sirt1 in Sf1-expressing neurons have increased susceptibility to diet-induced obesity and insulin resistance.

MT binding domain drives amyloid structure formation.

Female carriers of the Apolipoprotein E4 (APOE4) allele have decreased risk for dementia.

IgA plasma cells that are specific for transglutaminase 2 are scarce in the duodenal mucosa of celiac disease patients when the disease is active.

Ambulatory blood pressure monitoring is inaccurate at diagnosing hypertension.

Nonhypertensive people who are 55 years old have a 90% chance of developing hypertension during their lifetime.

In patients with congenital heart defects, β-blockers significantly improve clinical heart failure outcomes.

CRP is positively correlated with postoperative mortality following Coronary Artery Bypass Graft (CABG) surgery.

Risk of cardiovascular events can be cut by a third by using antihypertensive drug therapy among hemodialysis patients.


Surfactin producing cells and exopolymer producing cells cooperate to generate "Van Gogh" bundles that have sliding abilities on specialized media.

DRD1 proteins enable Pol V transcription in vivo.

Increased conversion of PGE 2 to PPARy ligand 15-ket-PGE 2 causes accumulation of PGE.

Blocking the interaction between TDP-43 and respiratory complex I proteins ND3 and ND6 prevents TDP-43-induced neuronal loss.

Bone Marrow (BM) transplantation is used to treat acute myeloid leukemia (AML)

Phase information is useful for predicting donor-recipient matches in organ transplantation.

The TRaF1/C5 rs10818488 allele polymorphism regulates the neighboring C5 gene.

Guanine nucleotide exchange factors (GEFs) mediate RhoA activation in response to tensional forces on fibronectin-binding integrins.

32% of liver transplantation programs required patients to discontinue methadone treatment in 2001.

Students who perform poorly in the early years of medical school are less likely to commit professional misconduct later in their careers.

Ethanol stress increases the expression of SRL in bacteria.

Inhibiting focal adhesion formation increases the rate at which cells convert mechanical strain into inflammation and fibrosis.

0-dimensional biomaterials lack inductive properties.

Inhibiting focal adhesion formation enables cells to convert mechanical strain into eventual scarring.

The microtubule-dependent delivery and secretion of matrix metalloproteases (MMPs) is partially responsible for the disassembly of adhesion sites.

Ca2+ cycling controls whole-body energy homeostasis in beige fat.

Myelin sheaths play a role in action potential propagation.

MICAL redox enzymes regulate actin dynamics in many cell types.

The C-type lectin receptor (CLEC-2) rearranges the actin cytoskeleton in dendritic cells to promote efficient motility along stromal surfaces.

Drosophila supracellular actomyosin structures are found at boundaries in wing imaginal discs.


Surgical treatment is not superior to non-surgical in treating adults with displaced fractures of the proximal humerus.

AZT given with ribavirin increases anemia.

Perigenital skin is not the primary site of HIV acquisition.

Genomic aberrations of metastases provide information for targeted therapy.

MICAL redox enzymes regulate actin dynamics in many cell types.

Mitochondria play a major role in apoptosis.

Intra-cerebroventricular infusion of amyloid-β oligomers reduces expression of fibronectin type-III domain-containing protein 5 mRNA in mice hippocampi.

Aggravated inflammation is dependent on NLRP3 inflammasome activation.

HOXB4 is a highly expressed component of cellular secretome from fetal liver cell populations.

There is no association between HNF4A mutations and diabetes risks.

The peak incidence of fractures occurs in toddlers.

Osteoparthritis (OA) is characterized by degeneration of articular cartilage, joint edge, and subchondral bone hyperplasia.

The peak incidence of fractures occurs during pubertal growth spurt in early adolescents.

Rotator cuff exercises are more effective than general exercise therapy in reducing pain and improving function of the shoulder.

General exercise therapy is more effective than rotator cuff exercises in reducing pain and improving function of the shoulder.

General exercise therapy is more effective than scapular stabilizer exercises in reducing pain and improving function of the shoulder.

Roughly 55% of women with chronic pelvic pain have no underlying pathology.

Scapular stabilizer exercises are more effective than general exercise therapy in reducing pain and improving function of the shoulder.

There is a positive correlation between hip fractures and statin use.


Sweet taste receptors on the tongue are deactivated by between 1 and 10 mM glucose.

Surfactin producing cells and exopolymer producing cells cooperate to generate "Van Gogh" bundles that have sliding abilities on specialized media.

HIV trans-activator protein (TAT) effectively transports large and small molecules across cellular membranes into larger populations of neurons.

Nigerian physicians constitue the largest component of sub-Saharan Africa-trained physicians in the United States.

Men are more susceptible to death due to pneumonia when compared to women.

Increased microtubule acetylation repairs interference of axonal transport caused by LRRK2 Roc-COR domain mutations.

Genes regulated by Esrrb transcription factor are sensitive to Mbd3 function.

Ethanol stress increases the expression of PSP in bacteria.

Pioglitazone use is not associated with an increased risk of prostate cancer.

Osteocytes have an essential role in G-CSF induced HSPC mobilization.

Insulin effects appetite via ventral tegmental neurons.

Inhibiting glucose-6-phospate dehydrogenase improves lipogenesis by deactivating LKB1-AMPK signaling.

The most prevalent adverse events to Semaglutide are gastrointestinal.

Taxation of sugar-sweetened beverages reduced the incidence rate of type II diabetes in India.

Moderate consumption of candy and chocolate reduces the risk of cardiovascular disease (CVD).

It is not proven that moderate consumption of candy and chocolate reduces the risk of cardiovascular disease (CVD) specifically.

Autophagy deficiency in the liver increases vulnerability to insulin resistance.

Glucose restriction to 0.05% reduces RLS (replicative life span) by 20-40% in S. cerevisiae.

Healthy volunteers exhibit rapid and transient increase of cellular ATP after being bolus-injected with fructose.


Sympathetic nerve activity is elevated throughout normal pregnancy.

Gpr124 suppresses BBB breakdown in mouse models of ischemic stroke.

Ly49Q directs the organization of neutrophil polarization by regulating membrane raft functions.

Low expression of miR7a does not repress target genes or exert a biological function in testis.

ATM and Rad3 related protein have no role in sensing DNA damage.

Ca2+ cycling is a UCP1-independent thermogenic mechanism.

Reduced phosphorylation of PP2A suppresses HDAC4 dephosphorylation.

Risk of cardiovascular events can be cut by a third by using antihypertensive drug therapy among hemodialysis patients.

Vaccinating the gastrointestinal tract induces protection of rectal and vaginal mucosa.

The mean suicide rate in women is higher after miscarriage than live birth.

Epidemiological disease burden from noncommunicable diseases is more prevalent in high economic settings.

Sympathetic nerve activity is reduced throughout normal pregnancy.

Sudden death can occur in patients with orthostatic hypertension without cardiac conduction abnormalities.

Excess gestational weight gain is associated with obesity-related pregnancy outcomes.

Vitamin D is an important factor in the relationship between calcium and parathyroid hormone.

Cardiac tissue-resident macrophages directly contribute to electrical activity.

Increased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm.

Lack of FGF21 in mice increases life expectancy.


Sympathetic nerve activity is reduced throughout normal pregnancy.

Klf4 is not required for proper myeloid cell differentiation.

Long chain polyunsaturated fatty acids supplementation is associated with lower rates of atopic eczema at 1 year.

Pyridostatin induces checkpoint activation.

High levels of CRP lead to a higher risk of exacerbations in chronic obstructive pulmonary disease (COPD).

Varenicline monotherapy is more effective after 26 weeks of treatment compared to combination nicotine replacement therapies with varenicline or bupropion.

Combination nicotine replacement therapies with varenicline or bupropion are more effective after 12 weeks of reatment compared to varenicline monotherapy.

Gastric lavage is an effective treatment for acute paraquat poisoning.

Occipital activation levels are associated with auditory spatial performance in parietal regions of the brain.

Klf2 is important for proper myeloid cell function.

The mean suicide rate in women is lower after miscarriage than live birth.

The mean suicide rate in women is higher after miscarriage than live birth.

Incidence of heart failure increased by 10% in women since 1979.

Noninvasive positive pressure ventilation is not predictive of acute respiratory failure after solid organ transplantation.


Systemic immunosuppressive (IS) therapy does not enhance the chance of cancer mortality in patients with inflammatory eye disease (IED)

BCL-2 promotes the apoptotic effects of c-Myc.

Mutations in G-Beta protein GNB1 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.

Surgical treatment is not superior to non-surgical in treating adults with displaced fractures of the proximal humerus.

MT binding domain drives amyloid structure formation.

In domesticated populations of Saccharomyces cerevisiae, segmental aneuploidy is very common.

Taking anti-depresents is associated with a decrease in the Aβ level in the brain of experimental animals.

Comparative transcriptome analysis identified new platelet proteins with structural features suggesting a role in platelet function.

Patients with microcytosis and higher erythrocyte count were more resistant to severe malarial anaemia when infected with Plasmodium falciparum.

Distant CREs are important for transcriptional regulation.

Increased mobility of retrotransposons is assosciated with mutation and higher tumorigenesis rates.

Systemic immunosuppressive (IS) therapy increases the chance of cancer mortality in patients with inflammatory eye disease (IED)

Stroke patients with prior use of direct oral anticoagulants have a higher risk of in-hospital mortality than stroke patients with prior use of warfarin.

Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission.

Metastatic colorectal cancer treated with a single agent fluoropyrimidines resulted in similar efficacy and better quality of life when compared with oxaliplatin-based chemotherapy in elderly patients.

Side effects associated with antidepressants increases risk of stroke.

The most prevalent adverse events to Semaglutide are cardiovascular.

The most prevalent adverse events to Semaglutide are gastrointestinal.

Diabetic patients with acute coronary syndrome experience decreased short-term and long-term risk for bleeding events.

Antimicrobial agents are less effective due to the pressure of antimicrobial usage.


Systemic immunosuppressive (IS) therapy increases the chance of cancer mortality in patients with inflammatory eye disease (IED)

Tonic signaling from the scFv prevents constitutive stimulation.

The PPR MDA5 has twenty N-terminal CARD domains.

GATA3 regulates cell cycle progression in bone marrow hematopoietic stem cells.

Pure neural progenitor cell (NPC) populations can only be obtained from cell cultures that undergo passaging, filtration, or other isolation and cell sorting methods.

Incidence of sepsis has fallen substantially from 2009 to 2014.

A low percentage of hematopoietic progenitor cells are susceptible to HIV-1 infection ex vivo.

Sequence conservation in gene regulatory regions between species is a poor predictor of conserved functionality.

FACT and other histone chaperone(s) compensate for Histone 2A (H2A)-histone 2B (H2B) dimer eviction during the histone exchange process.

Upregulation of dynein in Drosophila neurons increases the number of microtubule plus-ends growing toward the cell body of each neuron.

Enhanced early production of inflammatory chemokines damages viral control in the lung.

Side effects associated with antidepressants lower risk of myocardial infarction.


Systemic lupus erythematosus is a risk factor for cardiovascular disease.

Medications to treat obesity do not have side effects.

Nonsteroidal antinflammatory drugs are ineffective as cancer treatments.

Pioglitazone use is significantly associated with an increased risk of prostate cancer.

Nonhypertensive people who are 55 years old have a 90% chance of developing hypertension during their lifetime.

Formation of N-terminal pyroglutamate by glutamine cyclase (GC) competes with NTAQ1 for Nt-Gln substrates.

Environmentally-induced senescence is mimicked in disease modeling by adding specific molecules to the culture system.

Active Ly49Q prevents neutrophil polarization.

The tissue surrounding the granuloma in an immune cell induces an anti-inflammatory immune response.

Folate and vitamin B12 levels influence the association between homocysteine and preeclampsia.

Risk of cardiovascular events can be cut by a third by using antihypertensive drug therapy among hemodialysis patients.

CRP is positively correlated with postoperative mortality following Coronary Artery Bypass Graft (CABG) surgery.

LDL cholesterol has a causal role in the development of cardiovascular disease.

In young and middle-aged adults, current or remote uses of ADHD medications increase the risk of serious cardiovascular events.

In British Men, haplogroup I increases risk of cardiovascular disease by 50%.

Sudden death can occur in patients with complex ventricular arrhythmias.

IL-6 signaling plays a major role in atherosclerotic cardiovascular disease.

In British Men, haplogroup I decreases risk of cardiovascular disease.


T cell receptor /CD3 microdomains are required to induce the immunologic synapse.

R2D2 stops miRNA production by increasing the selectivity of Dcr2 for long dsRNA.

Antidepressants increase the severity of migraines.

Splenomegaly is observed in knockin mouse lacking the SHP-2 MAPK pathway.

B3-Galectin increases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR.

A single nucleotide variant the gene DGKK is strongly associated with increased risk of hypospadias.

During non-homologous end joining, the ligation step is not as tolerant of disrepairs and other distortions when joining 3' of strand breaks as compared to 5' strand breaks.

Sn is present on mature DCs during inflammation in vivo.

4-PBA treatment decreases endoplasmic reticulum stress in response to general endoplasmic reticulum stress markers.

Cost effectiveness evaluations based on cRCT data accurately reflect prices for patients in actual clinical practice.

Intra-cerebroventricular infusion of amyloid-β oligomers reduces expression of fibronectin type-III domain-containing protein 5 mRNA in mice hippocampi.

Major antigen-induced signals from the T cell receptor and secondary signals from costimulatory receptors are required for T cell activation.

ITAM phosphorylation allows for the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).

CD28 signals regulate trafficking of murine auto-reactive T cells into target tissues.

Egr3 regulates the homeostasis of B and T cells.

Many transmembrane receptors transmit signals by long-range conformational changes in the association of alpha-helices across the plasma membrane.

Egr2 regulates the homeostasis of B and T cells.

Reduced responsiveness to interleukin-2 in regulatory T cells is associated with autoimmune diseases such as Type 1 Diabetes.

Peroxynitrite is required for induction of T cell tolerance.

The density of cytokine receptor bearing cells affects the distance over which cytokines act.


C2 works synergistically with A-769662 to activate dephosphorylated AMPK.

V-9302 inhibits antitumor responses by decreasing cell death and oxidative stress.

Genes involved in pre-mRNA splicing have a significant impact on genome stability.

Occipital activation levels are associated with auditory spatial performance in parietal regions of the brain.

Lysine histone demethylase inhibitor JIB 04 is inactive against KDM5A.

Increased lipolysis leads to higher P38 phosphorylation in adipose tissue.

Mutant mice lacking SVCT2 have severely reduced ascorbic acid levels in both brain and adrenals.

Sequence conservation in gene regulatory regions between species is a poor predictor of conserved functionality.

Type 1 Diabetes is associated with subtle perturbations in T reg development.

The density of cytokine receptor bearing cells has no effect on the distance over which cytokines act.

Foxp3 enables the expression of transcriptional regulators implicated in memory T cell development.

Foxp3 represses the expression of transcriptional regulators implicated in memory T cell development.

IL-10 production by monocytes inhibits CD4 + T cell response.

Foxk2 regulates autophagy genes in muscle cells and fibroblast cells.


TNFAIP3 is a glioblastoma tumor enhancer.

The M2-phenotype in brown adipose tissue macrophages increases brown adipose tissue thermogenic activity.

In breast cancer, the loss of myoepithelial cells promotes the transition of ductal carcinoma in situ to invasive carcinoma.

Activation of the Rac1 homolog CED-10 kills viable cells in SRGP-1 mutant Caenorhabditis elegans.

Omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegans.

The DESMOND program caused substantial weight loss in most participants.

Cytosolic proteins bind to iron-responsive elements on mRNAs coding for TFRC1.

Reduction of purity of cytoplasmic membranes isolated from overexpressors is indicated by stronger spots for OmpF in 2D BN-PAGE gels.

BLM gene encodes RecQ-class DNA helicase.

Carriers of HNF4A mutations are at reduced risk for diabetes.

Piezo1 channels are sensors for cell migration in epithelial cells.

TNFAIP3 is a glioblastoma tumor suppressor.

TNFAIP3 is a tumor enhancer in glioblastoma.

GATA3 regulates cell cycle progression in bone marrow hematopoietic stem cells.

MafA phosphorylation enhances its ubiquitination.

Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes fibrosis.

GATA3 regulates self-renewal capacity in bone marrow hematopoietic stem cells.

ALDH1 expression is associated with poorer prognosis for breast cancer primary tumors.


TNFAIP3 is a glioblastoma tumor suppressor.

Depletion of nitric oxide is responsible for vasospasm.

The DESMOND program demonstrates no significant impact on biochemical outcomes.

Cyclin A2 destruction is necessary to switch from unstable to stable kt-mt attachments in mitosis.

The relationship between a breast cancer patient's capacity to metabolize tamoxifen and treatment outcome is independent of the patient's genetic make-up.

Eliminating the last sporadic cases of malaria requires considerable funding.

Low expression of miR7a does not repress target genes or exert a biological function in ovaries.

Comparative transcriptome analysis identified new platelet proteins with structural features suggesting a role in platelet function.

ATM and Rad3 related protein are critical for sensing DNA damage.

Removal of H3K9me3 by ectopic expression of other H3K9 demethylases improves reprogramming efficiency in SCNT experiments.

ERAP1 SNPs are epistatic to HLA alleles for ankylosing spondylitis.

The minor G allele of FOXO3 up-regulates IL-10.


TNFAIP3 is a tumor enhancer in glioblastoma.

Microglia are an innate immune cell type of the peripheral nervous system.

Differentiation of progenitor cells to myeloid cells is skewed when insulin signaling is suppressed.

The World Health Organization's (WHO) data collection process is biased downward by unequal selection of larger outbreaks.

In young and middle-aged adults, current or remote uses of ADHD medications increase the risk of serious cardiovascular events.

KRT17 modulates the expression of the transcriptional regulator AIRE in diseased epithelia.

1-1% of colorectal cancer patients are diagnosed with regional or distant metastases.

A diminished ovarian reserve is a very strong indicator of infertility, even in an a priori non-infertile population.

L3MBTL2 binds to H2AK119Ub marked chromatin to form a PRC1 complex.


TRAP+ osteoclasts regulate mature osteoblast maintenance.

Pro-inflammatory cytokines are up regulated during tumor development.

Crossover hot spots are found within gene promoters in Saccharomyces cerevisiae.

Decreased conversion of PGE 2 to PPARy ligand 15-ket-PGE 2 causes accumulation of PGE.

Female carriers of the Apolipoprotein E4 (APOE4) allele have increased risk for Alzheimer's disease.

Commelina yellow mottle virus' (ComYMV) genome consists of 2140 baise pairs.

Having a main partner improves HIV outcomes.

H4 G94P proteins inhibit chromatin assembly, which decreases free histones.

PGE 2 suppresss intestinal tumor growth by altering the expression of tumor suppressing and DNA repair genes.

CDK6 shows improved binding to loss-of-function variants of p18 INK4C.

F4/80+ macrophages regulate mature osteoblast maintenance.

Osteoparthritis (OA) is characterized by degeneration of articular cartilage, joint edge, and subchondral bone hyperplasia.

Osteocytes have an essential role in G-CSF induced HSPC mobilization.

The microtubule-dependent delivery and secretion of matrix metalloproteases (MMPs) is partially responsible for the disassembly of adhesion sites.

MT binding domain drives amyloid structure formation.

Allogeneic mechanical circulatory support is not as effective as autologous mechanical circulatory support for treating acute myocardial infarction.

Intramembrane cleavage by signal peptide peptidase aids in the degradation of proteins with a complex membrane orientation.

Induction of urokinase receptor signaling in podocytes causes foot process effacement and proteinuria.

MFGE8 regulates fat absorption by binding to av-Beta3 and av-Beta5 integrins.


Taking 400mg of α-tocopheryl acetate does not prevent prostate cancer.

Noninvasive positive pressure ventilation is not predictive of acute respiratory failure after solid organ transplantation.

cSMAC formation represses weak ligand signalling.

Lack of FGF21 in mice leads to reduced lifespan.

Misunderstandings between doctors and patients can lead to non-adherence.

Inhibiting focal adhesion formation enables cells to convert mechanical strain into eventual scarring.

Side effects associated with antidepressants do not represent a mortality risk to postmenopausal women.

Algerian physicians constitue the largest component of sub-Saharan Africa-trained physicians in the United States.

The tip of the inner tube of the toxic type VI secretion system (T6SS) antibacterial effector in Escherichia coli (E. coli) is decorated with VgrG and PAAR proteins.

Gastric infection with Helicobacter pylori increases risk of gastric cancer in humans.

Taking 400mg of α-tocopheryl acetate in combination with vitamin C reduces the risk of prostate cancer.

Pioglitazone use is not associated with an increased risk of prostate cancer.

Pioglitazone use is significantly associated with an increased risk of prostate cancer.

Pioglitazone use is significantly associated with an increased risk of pancreatic cancer.

Sildenafil worsens erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.

Decrease of p62 in prostate tumor stroma results in defective autophagy.

Increase of p62 in prostate tumor stroma results in defective autophagy.

A breast cancer patient's capacity to metabolize tamoxifen influences treatment outcome.

Ten percent (10%) of kidney cancers in the UK are attributable to excess weight.


Taking 400mg of α-tocopheryl acetate in combination with vitamin C reduces the risk of prostate cancer.

Induced hepatic stem cells possess the potential to differentiate into cholangiocytic cells.

NR5A2 is important in reverse cholesterol transport in humans.

A diminished ovarian reserve does not solely indicate infertility in an a priori non-infertile population.

Monoclonal antibody targeting of N-cadherin inhibits castration resistance.

Mitochondria play a major role in energy production.

Sepsis related mortality has risen from 2009 to 2014.

The appearance of brown-like or beige cells primarily occurs in visceral fat, not subcutaneous fat.

Cognitive behavioral therapy is an ineffective treatment for insomnia

Bone marrow cells don't contribute to adult macrophage compartments.

Upregulation of PD1 causes the upregulation of Satb1.

Dexamethasone increases risk of postoperative bleeding.


Taking anti-depresents is associated with a decrease in the Aβ level in the brain of experimental animals.

PKG-la does not have a large impact on expression of spinal long term potentiation in PGK-la knockout mice.

Increased purity of cytoplasmic membranes isolated from overexpressors is indicated by stronger spots for OmpF in 2D BN-PAGE gels.

Taxation of sugar-sweetened beverages reduced the incidence rate of type II diabetes in India.

Reduction of purity of cytoplasmic membranes isolated from overexpressors is indicated by stronger spots for OmpA in 2D BN-PAGE gels.

Propriospinal interneurons that play a role in the plastic reorganization of spinal circuits are integral for recovery from spinal cord injury.

Pseudogene PTENP1 encodes a transcript that regulates PTEN expression.

Inhibiting glucose-6-phospate dehydrogenase improves lipogenesis by deactivating LKB1-AMPK signaling.

Surfactin producing cells and exopolymer producing cells cooperate to generate "Van Gogh" bundles that have sliding abilities on specialized media.

Pseudoknots are not evolutionarily conserved in most eukaryotes.

Side effects associated with antidepressants increases risk of stroke.

In patients with congenital heart defects, β-blockers significantly improve clinical heart failure outcomes.

Side effects associated with antidepressants lower risk of myocardial infarction.

The most prevalent adverse events to Semaglutide are cardiovascular.

The most prevalent adverse events to Semaglutide are gastrointestinal.

Antiretroviral therapy increases rates of tuberculosis across a broad range of CD4 strata.

Side effects associated with antidepressants do not represent a mortality risk to postmenopausal women.

Antidepressants increase the severity of migraines.

Exhaustion of B cells contributes to poor Ab response in HIV-infected individuals.


Taxation of sugar-sweetened beverages reduced the incidence rate of type II diabetes in India.

Patients with microcytosis and higher erythrocyte count were more resistant to severe malarial anaemia when infected with Plasmodium falciparum.

HAND2 methylation is a key step in early endometrial carcinogenesis.

DRD1 proteins enable Pol V transcription in vivo.

Radioiodine treatment of non-toxic multinodular goitre increases thyroid volume.

The gene daf-16, which encodes forkhead Box O (FOXO), is required for all phenotypes associated with reduced insulin/insulin-like growth factor (Igf) signaling.

Ultrasound guidance significantly reduces the number of traumatic procedures when attempting needle insertion.

Anthrax spores are very difficult to dispose once they are dispersed.

TNFAIP3 is a tumor enhancer in glioblastoma.

Cost effectiveness evaluations based on cRCT data lack external validity.

Microglia are an innate immune cell type of the peripheral nervous system.

Consumption of whole fruits increases the risk of type 2 diabetes.

It is not proven that moderate consumption of candy and chocolate reduces the risk of cardiovascular disease (CVD) specifically.

Moderate consumption of candy and chocolate reduces the risk of cardiovascular disease (CVD).

Autophagy deficiency in the liver increases vulnerability to insulin resistance.

Exercise increases cancer mortality rates among Chinese citizens.

Exercise reduces cancer mortality rates among Chinese citizens.

The risk of cancer rises with level of alcohol consumption.

Medications to treat obesity have unwanted side effects.

Reduced levels of lipolysis leads to higher P38 phosphorylation in adipose tissue.


Ten percent (10%) of kidney cancers in the UK are attributable to excess weight.

BiP is a general endoplasmic reticulum stress marker.

Glycan adaptation is rarely observed in the B-cell repertoire.

During non-homologous end joining, the ligation step is not as tolerant of disrepairs and other distortions when joining 3' of strand breaks as compared to 5' strand breaks.

Distant CREs are important for transcriptional regulation.

Insulin decreases risk of severe kidney failure.

Removal of H3K9me3 by ectopic expression of other H3K9 demethylases decreases reprogramming efficiency in SCNT experiments.

MafA ubiquitination decreases the recruitment of coavtivator P/CAF by MafA.

Primary cervical cytology screening with HPV detection has higher longitudinal sensitivity to detect severe cervical intraepithelial neoplasia than conventional cytology.

Binding of p53 to enhancer regions (p53BERs) regulates the activity of p53 transcription and cell cycle arrest through the production of p53-dependent eRNAs.

Women with a lower birth weight are more likely to develop breast cancer later in life.

61% of colorectal cancer patients are diagnosed with regional or distant metastases.

1-1% of colorectal cancer patients are diagnosed with regional or distant metastases.

Birth-weight is negatively associated with breast cancer.

The risk of breast cancer among parous women decreases with placental weight of pregnancies.

In British Men, haplogroup I increases risk of cardiovascular disease by 50%.

Environmental factors can influence the development of breast cancer.

In breast cancer, the loss of myoepithelial cells promotes the transition of ductal carcinoma in situ to invasive carcinoma.

In British Men, haplogroup I decreases risk of cardiovascular disease.


The C-type lectin receptor (CLEC-2) rearranges the actin cytoskeleton in dendritic cells to promote efficient motility along stromal surfaces.

Migraine with aura is associated with ischemic stroke.

Sudden death can occur in patients with orthostatic hypertension without cardiac conduction abnormalities.

Mouse models can be generated using "artificial spermatids."

Physical activity level is associated with the difference in maximal oxygen consumption between black and white youth.

Assessing treatment adherence is more beneficial to clinical practice than measuring routine outcomes.

Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 encourage West Nile virus replication in cortical neurons.

IFI16 impedes STING phosphorylation and translocation, resulting in reduced activation of STING.

Medications to treat obesity have unwanted side effects.

JMJD6 slows the hydroxylation of C-terminal lysine

The PDPN gene deactivates the C-type lectin receptor (CLEC-2).

Fibroblast Growth Factor is a ligand which signals through receptor tyrosine kinases.

Kir7.1 modulates channel activity by the G protein-coupled melanocortin-4 receptor (MC4R) in the paraventricular nucleus of the hypothalamus.

MICAL redox enzymes regulate actin dynamics in many cell types.

Drosophila supracellular actomyosin structures are found at boundaries in wing imaginal discs.

Guanine nucleotide exchange factors (GEFs) mediate RhoA activation in response to tensional forces on fibronectin-binding integrins.

ITAM phosphorylation allows for the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).

Upregulation of dynein in Drosophila neurons increases the number of microtubule plus-ends growing toward the cell body of each neuron.

RTEL1 interacts with TRF2 through a C4C4 motif


The DESMOND program caused substantial weight loss in most participants.

Increased lipolysis leads to higher P38 phosphorylation in adipose tissue.

RUNX1 is downregulated or mutated in TLX1 T-ALL.

Mice lacking Sirt1 in Sf1-expressing neurons have increased susceptibility to diet-induced obesity and insulin resistance.

The artifactual C-terminal helix swapping in the StART domain is observed in the Ups1-Mdm35 heterodimer of the StARkin superfamily.

Human embryonic stem cells give rise to cell types from the outer embryonic germ layer, but not the other two layers.

In S. cerevisiae, the absence of RNA surveillance pathways reduces sensitivity to high iron conditions.

Pseudogene PTENP1 encodes a transcript that regulates PTEN expression.

Elevated cell-free mitochondrial DNA levels are associated with mortality.

50% of patients exposed to radiation have activated markers of mesenchymal stem cells.

The DESMOND program demonstrates no significant impact on weight loss.

The DESMOND program demonstrates no significant impact on lifestyles outcomes.

The DESMOND program demonstrates no significant impact on biochemical outcomes.

Excess gestational weight gain is associated with obesity-related pregnancy outcomes.

Input from  mental and physical health care professionals is not effective at decreasing homelessness.

32% of liver transplantation programs required patients to discontinue methadone treatment in 2001.

Dexamethasone increases risk of postoperative bleeding.

Individuals with Alzheimers who participate in six months of physical activity improve cognitive function for up to 18 months.

Participants who quit smoking reduce lung cancer risk by approximately 50%.


The DESMOND program demonstrates no significant impact on biochemical outcomes.

Reduced phosphorylation of PP2A suppresses HDAC4 dephosphorylation.

In pediatric tissue, most T cells are naive T cell emigrants from the thymus.

Origin gross domestic product(GDP) is positively related to dengue virus (DENV-1) diffusion in air traffic shipments.

APOE4 expression in iPSC-derived neurons results in decreased tau phosphorylation.

Foxp3 represses the expression of transcriptional regulators implicated in memory T cell development.

Incidence of heart failure increased by 10% in women since 1979.

p16INK4A degradation is  linked to an abnormal wound response caused by the microinvasive step of advanced Oral Potentially Malignant Lesions (OPMLs).

Physical activity level has no association with the difference in maximal oxygen consumption between black and white youth.

Early patent ductus ateriosus (PDA) screening decreases in-hospital mortality.

miR-142-5P is a known regulator of raised body temperature.

Cost effectiveness evaluations based on cRCT data lack external validity.

Therapeutics receiving accelerated approval encounter a lower frequency of post-marketing safety events

Cost effectiveness evaluations based on cRCT data accurately reflect prices for patients in actual clinical practice.

There is no association between HNF4A mutations and diabetes risks.

Androgenetic haploid mouse embryonic stem cells (ESCs) can be derived and genetically manipulated in vitro.

Measuring routine outcomes is more beneficial to clinical practice than assessing treatment adherence.


The DESMOND program demonstrates no significant impact on lifestyles outcomes.

Students who perform poorly in the early years of medical school are at increased risk for professional misconduct later in their careers.

Mice defective for deoxyribonucleic acid (DNA) polymerase m (polm) reveal increased sensitivity to ionizing radiation (IR).

Neutrophils produce IL-1β in response to large particles.

Increased conversion of PGE 2 to PPARy ligand 15-ket-PGE 2 causes accumulation of PGE.

Destination container port throughput(CPT) is negatively related to dengue virus (DENV-1) diffusion in air traffic shipments.

Adult tissue-resident macrophages stem from the embryonal yolk sac and fetal liver.

The repeat-variable diresidue (RVD) in the loop of Transcription-Activator Like (TAL) effectors specifies the nucleotides-amino acid contact at the target promoter element.

PRC1-bound plasmids sediment at a slower rate in unbound plasmids than in sucrose gradients.

Helminths interfere with immune system control of coinfections by microbial pathogens 16.

Integrated care is ineffective at tackling multiple comorbidities.

Incidence of 10/66 dementia is lower than the incidence of DSM-IV dementia.

Integrated care is successful at tackling multiple comorbidities.

Self-advocacy training is effective at decreasing homelessness.

Incidence of 10/66 dementia is higher than the incidence of DSM-IV dementia.


The DESMOND program demonstrates no significant impact on weight loss.

MT binding domain drives amyloid structure formation.

Cancers that initially benefit from epidermal growth factor receptor targeted therapies later become refractory through several mechanisms.

In transgenic mice harboring green florescent protein under the control of the Sox2 promoter, more than 50 percent of the cells with green florescent colocalize with cell proliferation markers.

PKG-la plays an essential role in expression of spinal long term potentiation in PGK-la knockout mice.

Rapid phosphotransfer rates are correlated with histidine kinase regulator specificity.

Bariatric surgery leads to negative outcomes in mental health.

Toll-like receptor (TLR) signaling is involved in the pathogenesis of human MDS.

Weighed food records (WFR) result in high completion since they're cheap to run and impose low participant burden.

Genetic deficiency of mast cells leads to decreased weight gain in a mouse model of diet-induced obesity.

aPKCz causes tumour suppression by affecting glutamine metabolism.

The DESMOND program caused substantial weight loss in most participants.

The DESMOND program demonstrates no significant impact on lifestyles outcomes.

The DESMOND program demonstrates no significant impact on biochemical outcomes.

Excess gestational weight gain is associated with obesity-related pregnancy outcomes.

For every 1,000 children with cerebral palsy, more than 300 of them are premature or underweight at birth.

Input from  mental and physical health care professionals is not effective at decreasing homelessness.

Individuals with Alzheimers who participate in six months of physical activity improve cognitive function for up to 18 months.

Medications to treat obesity do not have side effects.


The DEXI promoter region is bound by multiple transcription factors in a murine haematopoietic progenitor cell line.

Myelin sheaths play a role in action potential propagation.

70% of burn patients are admitted for hospitalization and further treatment after appearing at hospital emergency wards or outpatient clinics.

Female carriers of the Apolipoprotein E4 (APOE4) allele have shorter lifetime exposure to estrogen due to a decreased reproductive period.

Normal granulomas form in the presence of TNF in Zebrafish.

TNFAIP3 is a tumor enhancer in glioblastoma.

Intake of folic acid (FA) and vitamin B6 (VB6) reduces levels of homocysteine.

Dexamethasone increases risk of postoperative bleeding.

The first MBT repeat of the four malignant brain tumor (4MBT) domain of Drosophila's Sfmbt and of the orthologous mammalian L3MBTL2 is required for the interaction with the spacer region of Drosophila's Pleiohomeotic (Pho) or its human ortholog YY1.

Omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegetarians.

TNFAIP3 is a glioblastoma tumor suppressor.

TNFAIP3 is a glioblastoma tumor enhancer.

KRT17 modulates the expression of the transcriptional regulator AIRE in diseased epithelia.

miRNAs regulate a unique suite of mRNAs to maintain homeostasis in cells.

MUC1-C activates the NF-κB p65 signaling pathway by interacting with IκB kinase ß.

BiP is a general endoplasmic reticulum stress marker.

Genes regulated by Esrrb transcription factor are sensitive to Mbd3 function.

Glioblastoma multiforme (GBM) is characterized by extensive invasion, rapid growth, necrosis, and angiogenesis.


The DdrB protein from Deinococcus radiodurans functions as a pentamer.

B3-Galectin increases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR.

The microtubule-dependent delivery and secretion of matrix metalloproteases (MMPs) is partially responsible for the disassembly of adhesion sites.

DMS3 protein enables Pol V transcription in vivo.

A breast cancer patient's capacity to metabolize tamoxifen influences treatment outcome.

Deltex has no known interactions with eIF3f.

Lamins are found within the inner layer of the mitochondrial membrane of all cells.

Aged patients are less susceptible to ischaemia/reperfusion injury.

Tuberculosis-induced granulomas express different immune system protein signatures than the surrounding tissue.

Increased flux of microbial products provokes immune responses.

Gpr124 suppresses BBB breakdown in mouse models of ischemic stroke.

Gpr124 increases BBB breakdown in mouse models of ischemic stroke.

Transcription factor EB induces transcription of pro-inflammatory cytokines in macrophages infected with Staphylococcus aureus.

Broadly HIV-1 Neutralizing Antibodies (bnAb) 10EB have no affinity for phospholipids.

R2D2 stops miRNA production by increasing the selectivity of Dcr2 for long dsRNA.

Toll-like receptor (TLR) signaling is involved in the pathogenesis of human MDS.

The PPR MDA5 has twenty N-terminal CARD domains.

Reduction of purity of cytoplasmic membranes isolated from overexpressors is indicated by stronger spots for OmpA in 2D BN-PAGE gels.


The G34R/V mutation creates a hypomethylated phenotype at the H3K36 histone.

BLM gene encodes RecQ-class DNA helicase.

Tonic signaling from the scFv prevents constitutive stimulation.

Integrated care is ineffective at tackling multiple comorbidities.

Antimicrobial agents are less effective due to the pressure of antimicrobial usage.

A mutation in HNF4A leads to an increased risk of developing diabetes by the age of 14 years.

Low expression of miR7a does not repress target genes or exert a biological function in ovaries.

A diminished ovarian reserve does not solely indicate infertility in an a priori non-infertile population.

Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission.

Adult tissue-resident macrophages stem from the embryonal yolk sac and fetal liver.

VgrG (Tssl) protein punctures membranes by forming a spike at the tip of the tube apparatus.

The G34R/V mutation does not create a hypomethylated phenotype at the H3K36 histone.

H4 G94P proteins induce degradation of free histones via Rad53-dependent mechanisms.

H4 G94P proteins induce chromatin assembly, which increases free histones.

H4 G94P proteins suppress degradation of free histones via Rad53-dependent mechanisms.

H4 G94P proteins inhibit chromatin assembly, which decreases free histones.

The minor G allele of FOXO3 is related to less severe symptoms of Crohn's Disease.

HNF4A mutations are associated with macrosomia in infancy.

The minor G allele of FOXO3 up-regulates IL-10.

Mutations in G-Beta protein GNB1 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.


The G34R/V mutation does not create a hypomethylated phenotype at the H3K36 histone.

Patients with microcytosis and higher erythrocyte count were more resistant to severe malarial anaemia when infected with Plasmodium falciparum.

Chenodeoxycholic acid treatment increases brown adipose tissue activity.

H4 G94P proteins induce chromatin assembly, which increases free histones.

miRNAs enforce homeostasis by suppressing low-level ''leaky'' transcription.

Medications to treat obesity have unwanted side effects.

Mice defective for deoxyribonucleic acid (DNA) polymerase m (polm) fail to reveal increased sensitivity to ionizing radiation (IR).

Cancer-associated fibroblasts (CAFs) have no known interaction with cancer cells in the formation and activation of CAFs.

r-protein chaperones are found in complexes with their r-protein binding partners.

Destination container port throughput(CPT) is negatively related to dengue virus (DENV-1) diffusion in air traffic shipments.


The H2A-H2B eviction defect is compensated for by other histone chaperone(s).

Helicobacter pylori-induced aberrant NF-kB-dependent expression of activation-induced cytidine deaminase contributes to the mutagenesis of host DNA.

Insulin decreases risk of severe kidney failure.

Microcin J25 inhibits nucleoside triphosphate (NTP) binding.

50% of patients exposed to radiation have activated markers of mesenchymal stem cells.

61% of colorectal cancer patients are diagnosed with regional or distant metastases.

Integrated care is successful at tackling multiple comorbidities.

Ethanol stress increases the expression of SRL in bacteria.

Bacteriophagaes MS2 and Qβ are members of the Leviviridae.

Inhibiting glucose-6-phospate dehydrogenase improves lipogenesis by deactivating LKB1-AMPK signaling.

Mice defective for deoxyribonucleic acid (DNA) polymerase I (polI) fail to reveal increased sensitivity to ionizing radiation (IR).

FACT and other histone chaperone(s) compensate for Histone 2A (H2A)-histone 2B (H2B) dimer eviction during the histone exchange process.

Replacement of histone H2A with H2A.Z accelerates gene activation in yeasts by destabilizing +1 nucleosomes.


The HSV-2 infection is typically asymptomatic.

Active Ly49Q prevents neutrophil polarization.

Lack of FGF21 in mice slows the rate of atherosclerotic plaque formation.

Depletion of nitric oxide is responsible for vasospasm.

Systemic immunosuppressive (IS) therapy increases the chance of cancer mortality in patients with inflammatory eye disease (IED)

Chlamydia trachomatis is most prevalent in the UK among sexually-experienced individuals aged 16 to 24.

Patients in stable partnerships progress from HIV to death at the same rate as patients not in partnerships.

Increased LDL receptors plays a role in the reduction of plasma Lp(a).

Propriospinal interneurons that play a role in the plastic reorganization of spinal circuits are integral for recovery from spinal cord injury.

Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection increases dissemination of Salmonella Typhimurium from the gut.

A low percentage of hematopoietic progenitor cells are susceptible to HIV-1 infection ex vivo.

Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection decreases dissemination of Salmonella Typhimurium from the gut.

The latent infection of myeloid cells with human cytomegalovirus induces a number of changes in gene expression.

The composition of myosin-II isoform switches from the A isoform to the B isoform during hematopoietic differentiation.

Approximately 250,000 people are infected with human T-cell lymphotropic virus type 1 in the United Kingdom.

Exhaustion of B cells contributes to poor Ab response in HIV-infected individuals.

Toll-like receptor (TLR) signaling is involved in the pathogenesis of human MDS.

Continued HHV-8 transmission among MSM in San Francisco may be explained by urogenital contact.


The M2-phenotype in brown adipose tissue macrophages increases brown adipose tissue thermogenic activity.

Lack of FGF21 in mice increases life expectancy.

Cyclin A2 destruction is necessary to switch from unstable to stable kt-mt attachments in mitosis.

R2D2 stops miRNA production by increasing the selectivity of Dcr2 for long dsRNA.

Varying expression levels of EBI2 affect the positioning and migration of B cells.

Enhanced early production of inflammatory chemokines damages viral control in the lung.

Sequence conservation in gene regulatory regions between species is a high-accuracy predictor of conserved functionality.

TNFAIP3 is a tumor enhancer in glioblastoma.

Rapid phosphotransfer rates are correlated with histidine kinase regulator specificity.

Lamins are found within the inner layer of the mitochondrial membrane of all cells.

A deficiency of folate increases blood levels of homocysteine.

An M2-like phenotype in brown adipose tissue macrophages is quickly induced by cold exposure.

The morphology change from large white adipocytes to small brown adipocytes is a sign of increased energy expenditure potential in white adipose tissue.

The morphology change from large white adipocytes to small brown adipocytes is a sign of decreased energy expenditure potential in white adipose tissue.

Chenodeoxycholic acid treatment increases brown adipose tissue activity.

Chenodeoxycholic acid treatment decreases brown adipose tissue activity.

Ca2+ cycling controls whole-body energy homeostasis in beige fat.

Increased lipolysis leads to higher P38 phosphorylation in adipose tissue.

Reduced levels of lipolysis leads to higher P38 phosphorylation in adipose tissue.

aPKCz causes tumour suppression by affecting glutamine metabolism.


The NF-κB essential modulator gene induces intestinal inflammation by promoting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death.

Mutations in RIM1 decrease levels of IME1 RNA.

Converting apoE4 to apoE3 by gene editing worsens the pathology associated with apoE4 in human iPSCderived neurons.

Physical activity level has no association with the difference in maximal oxygen consumption between black and white youth.

Patients in stable partnerships progress from HIV to death at the same rate as patients not in partnerships.

JMJD6 catalyzes the hydroxylation of C-terminal lysine and supresses transcriptional activity.

1 in 5 million in UK have abnormal PrP positivity.

The DEXI promoter region is bound by multiple transcription factors in a murine haematopoietic progenitor cell line.

ScPif1p has reduced binding ability to G-rich ssDNA compared to non-G-rich ssDNA.

Chlamydia trachomatis is most prevalent in the UK among individuals in their 50s and 60s.

Increased purity of cytoplasmic membranes isolated from overexpressors is indicated by stronger spots for OmpF in 2D BN-PAGE gels.

The NF-κB essential modulator gene prevents intestinal inflammation by inhibiting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death.

MUC1-C activates the NF-κB p65 signaling pathway by interacting with IκB kinase ß.

Ribosome-inactivating protein-2 (RIP-2) interacts with the p75 NTR death domain

ITAM phosphorylation allows for the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).

p16INK4A degradation is  linked to an abnormal wound response caused by the microinvasive step of advanced Oral Potentially Malignant Lesions (OPMLs).

Certain immunomodulator-human dialyzable leukocyte extract (hDLE) peptides are recognized by toll-like receptors (TLRs) on macrophages and dendritic cells.

AMP-activated protein kinase (AMPK) activation reduces inflammation-related fibrosis in the lungs.

The RANK-RANK-Ligand (RANKL) pathway is involved in the development of Aire-expressing medullary thymic epithelial cells (mTECs).

Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes fibrosis.


The NF-κB essential modulator gene prevents intestinal inflammation by inhibiting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death.

Cytochrome c is transferred from cytosol to the mitochondrial intermembrane space during apoptosis.

Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 inhibit West Nile virus replication in cortical neurons.

Albendazole is used to treat soil-transmitted helminths.

Mutations in G-Beta protein GNB1 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.

Activation of PPM1D enhances p53 function.

Medications to treat obesity are highly effective.

Sympathetic nerve activity is reduced throughout normal pregnancy.

Bone marrow cells don't contribute to adult macrophage compartments.

Ly6C hi monocytes have a higher inflammatory capacity than Ly6C lo monocytes.

Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes epithelial damage.


The PDPN gene deactivates the C-type lectin receptor (CLEC-2).

The US health care system can save up to $5 billion if 7% of patients waiting for kidney transplants participate in the optimized national kidney paired donation program.

MafA phosphorylation decreases its ubiquitination.

PrimPol generates short DNA replication intermediates on the leading strand during DNA replication.

In transgenic mice harboring green florescent protein under the control of the Sox2 promoter, more than 50 percent of the cells with green florescent colocalize with cell proliferation markers.

Adult tissue-resident macrophages stem from the embryonal yolk sac and fetal liver.

Asymptomatic visual impairment screening in elderly populations leads to improved vision.

1 in 5 million in UK have abnormal PrP positivity.

Egr2 regulates the homeostasis of B and T cells.

Sudden death can occur in patients with complex ventricular arrhythmias.

JMJD6 slows the hydroxylation of C-terminal lysine

The C-type lectin receptor (CLEC-2) rearranges the actin cytoskeleton in dendritic cells to promote efficient motility along stromal surfaces.

Activated Cdk5 phosphorylates the ATM protein in response to DNA damage.

BCL-2 activation antagonizes the apoptotic effects of c-Myc.

RTEL1 interacts with TRF2 through a C4C4 motif

BCL-2 promotes the apoptotic effects of c-Myc.

Activated Cdk5 regulates DNA damage-induced neuronal death.


The PPR MDA5 has twenty N-terminal CARD domains.

Hypothalamic glutamate neurotransmission is unrelated to energy balance.

Replacement of OCT4 and SOX2 genes with GATA3 is not capable of reprogramming human cells.

There is a relation between Erythromycin use and hypertrophic pyloric stenosis.

The risk of female prisoners harming themselves is ten times that of male prisoners.

Citrullinated proteins externalized in neutrophil extracellular traps act indirectly to disrupt the inflammatory cycle.

mcm 5 s 2 U is required for proper decoding of NNR codons in eukaryotes.

Medications to treat obesity have unwanted side effects.

For every 1,000 children with cerebral palsy, more than 300 of them are premature or underweight at birth.

Piezo1 channels are sensors for cell migration in epithelial cells.

Mice lacking Sirt1 in Sf1-expressing neurons have increased susceptibility to diet-induced obesity and insulin resistance.

The artifactual C-terminal helix swapping in the StART domain is observed in the Ups1-Mdm35 heterodimer of the StARkin superfamily.

Toll-like receptor (TLR) signaling is involved in the pathogenesis of human MDS.

R2D2 stops miRNA production by increasing the selectivity of Dcr2 for long dsRNA.

Emodin forms hydrogen bonds with residues involved in PGAM1 substrate binding.

Dscam1 acts as a hypervariable pattern-recognition receptor for the immune system.

BLM gene encodes RecQ-class DNA helicase.

Commelina yellow mottle virus (ComYMV) has three typical badnavirus ORFs, capable of encoding proteins 23, 15, and 216 kD.


The PRDM1 gene is a key determinant of primordial germ cells.

DRD1 proteins enable Pol V transcription in vivo.

Recognition of start codons depends on the translation initiation factor IF3.

A deficiency of vitamin B6 decreases blood levels of homocysteine.

Active caspase-11 protein promotes pyroptosis.

Inhibiting glucose-6-phospate dehydrogenase improves lipogenesis by deactivating LKB1-AMPK signaling.

Active H. pylori urease has a polymeric structure consisting of five distinct subunits.

1-1% of colorectal cancer patients are diagnosed with regional or distant metastases.

Increased microtubule acetylation repairs interference of axonal transport caused by LRRK2 Roc-COR domain mutations.

There was an estimated 30 million cases of pneumonia in young children worldwide in 2010.

0-dimensional biomaterials lack inductive properties.

The PRDM1 gene, when combined with the PRDM14 gene, plays an important role during primordial germ cell specification.

The myocardial cell lineage originally develops from cardiac progenitors of exclusively endodermal origin.

Rhythmic expression of Cry1 translates directly into a circadian regulation of cAMP signaling in hepatic glucose metabolism.

The Snf1 complex regulates carbon and energy metabolism in baker's yeast (Saccharomyces cerevisiae).

Human embryonic stem cells have the capacity to give rise to differentiated progeny representative of all three embryonic germ layers.

The proliferative capacity of progenitors is regulated cell-autonomously.

Activation of the Rac1 homolog CED-10 kills viable cells in SRGP-1 mutant Caenorhabditis elegans.

Binding of p53 to enhancer regions (p53BERs) regulates the activity of p53 transcription and cell cycle arrest through the production of p53-dependent eRNAs.

Rhythmic expression of Cry1 translates directly into a circadian regulation of cAMP signaling in gluconeogenesis.


The PRDM1 gene, when combined with the PRDM14 gene, plays an important role during primordial germ cell specification.

Bariatric surgery leads to negative outcomes in mental health.

Metastatic colorectal cancer treated with a single agent fluoropyrimidines resulted in similar efficacy and better quality of life when compared with oxaliplatin-based chemotherapy in elderly patients.

Polymeal nutrition increases cardiovascular mortality.

Asymptomatic visual impairment screening in elderly populations leads to improved vision.

Fibroblast growth factor 21 protects against atherosclerosis by modulating adiponectin and SREBP2 levels.

Glycan adaptation is rarely observed in the B-cell repertoire.

Mutant mice lacking SVCT2 have severely reduced ascorbic acid levels in both brain and adrenals.

Androgenetic haploid mouse embryonic stem cells (ESCs) can be derived and genetically manipulated in vitro.

LDL cholesterol has a causal role in the development of cardiovascular disease.

7-day-old adult Caenorhabditis elegans exhibit approximately 5% of the learning capacity seen in 1-day old adults.

Activation of PPM1D enhances p53 function.

MeCP2 influences the synaptic maturation of neurons.


Assessing treatment adherence is more beneficial to clinical practice than measuring routine outcomes.

Immune responses in immune cells are geographically segregated.

Removal of H3K9me3 improves reprogramming efficiency in human somatic cell nuclear transfer experiments.

Ly6C hi monocytes have a higher inflammatory capacity than Ly6C lo monocytes.

Acute ablation of KRAS causes severe growth impairment.

The recruitment of Wdr5 to its target loci depends on Kat8.

Rhythmic expression of Cry1 translates directly into a circadian regulation of cAMP signaling in gluconeogenesis.

7-day-old adult Caenorhabditis elegans exhibit approximately 75% of the learning capacity seen in 1-day old adults.

Peroxynitrite is required for induction of T cell tolerance.

The PPR MDA5 has twenty N-terminal CARD domains.

Toll-like receptor (TLR) signaling is involved in the pathogenesis of human MDS.

The artifactual C-terminal helix swapping in the StART domain is observed in the Ups1-Mdm35 heterodimer of the StARkin superfamily.

R2D2 stops miRNA production by increasing the selectivity of Dcr2 for long dsRNA.

Dscam1 acts as a hypervariable pattern-recognition receptor for the immune system.

Deltex has no known interactions with eIF3f.

BLM gene encodes RecQ-class DNA helicase.

TNFAIP3 is a glioblastoma tumor suppressor.


The RANK-RANK-Ligand (RANKL) pathway is involved in the development of Aire-expressing medullary thymic epithelial cells (mTECs).

B3-Galectin increases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR.

Primary cervical cytology screening with HPV detection has higher longitudinal sensitivity to detect severe cervical intraepithelial neoplasia than conventional cytology.

The most prevalent adverse events to Semaglutide are gastrointestinal.

Walking in traffic areas in London did not improve lung function in elderly adults.

The removal of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells.

There is no increased risk of hypospadias with clomiphene.

BRCA 1 mutation carriers' risk of breast and ovarian cancer depends on where the mutation is located.

Ambulatory blood pressure monitoring is inaccurate at diagnosing hypertension.

The mean suicide rate in women is lower after miscarriage than live birth.

RANK-RANKL pathway signalling is linked to development of Aire-expressing medullary thymic epithelial cells.

RANK-RANKL pathway signalling has no known association with development of Aire-expressing medullary thymic epithelial cells.

KRT17 modulates the expression of the transcriptional regulator AIRE in diseased epithelia.

AMP-activated protein kinase (AMPK) activation reduces inflammation-related fibrosis in the lungs.

The NF-κB essential modulator gene induces intestinal inflammation by promoting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death.

The NF-κB essential modulator gene prevents intestinal inflammation by inhibiting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death.

ITAM phosphorylation allows for the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).

ER-localized phosphatase Sac1 processes PI4P through coordination with OSBP and the endosome-localized protein sorting nexin 2.

The C-type lectin receptor (CLEC-2) rearranges the actin cytoskeleton in dendritic cells to promote efficient motility along stromal surfaces.


The Snf1 complex regulates carbon and energy metabolism in baker's yeast (Saccharomyces cerevisiae).

Blocking the interaction between TDP-43 and respiratory complex I proteins ND3 and ND6 prevents TDP-43-induced neuronal loss.

ERAP1 SNPs are epistatic to HLA alleles for ankylosing spondylitis.

Induction of urokinase receptor signaling in podocytes causes foot process effacement and proteinuria.

Omnivores produce less trimethylamine N-oxide from dietary I-carnitine than vegans.

A single nucleotide variant the gene DGKK is strongly associated with increased risk of hypospadias.

Early patent ductus ateriosus (PDA) screening decreases in-hospital mortality.

Addition of BMP4, activin A, CHIR99021, and SU504 to reprogramming fibroblasts generates, expands and maintains cardiovascular progenitor cells (CPCs)

Antidepressants increase the severity of migraines.

7-day-old adult Caenorhabditis elegans exhibit approximately 5% of the learning capacity seen in 1-day old adults.

ALDH1 expression is associated with poorer prognosis for breast cancer primary tumors.

Mitochondria play a major role in energy production.

Ethanol stress increases the expression of IBP in bacteria.

Oxidative phosphorylation is one of the primary glycometabolic pathways in cells.

Rhythmic expression of Cry1 translates directly into a circadian regulation of cAMP signaling in hepatic glucose metabolism.

MUC1-C activates the NF-κB p65 signaling pathway by interacting with IκB kinase ß.

Replacement of histone H2A with H2A.Z accelerates gene activation in yeasts by destabilizing +1 nucleosomes.

Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 encourage West Nile virus replication in cortical neurons.

miRNAs regulate a unique suite of mRNAs to maintain homeostasis in cells.

miR-142-5P is a temperature-sensitive microRNA (miRNA).


The TRaF1/C5 rs10818488 allele polymorphism regulates the neighboring C5 gene.

Adult tissue-resident macrophages are seeded before birth.

BLM gene encodes RecQ-class DNA helicase.

Cost effectiveness evaluations based on cRCT data lack external validity.

Cognitive behavioral therapy is an ineffective treatment for insomnia

Formation of N-terminal pyroglutamate by glutamine cyclase (GC) competes with NTAQ1 for Nt-Gln substrates.

Tonic signaling from the scFv induces constitutive stimulation.

Deletion of ATM and Rad3 related protein leads to acute tissue loss.

Exercise increases cancer mortality rates among Chinese citizens.

The proliferative capacity of progenitors is regulated cell-autonomously.

CRP is positively correlated with postoperative mortality following Coronary Artery Bypass Graft (CABG) surgery.

RTEL1 interacts with TRF2 through a C4C4 motif

The PPR MDA5 has twenty N-terminal CARD domains.

mcm 5 s 2 U is required for proper decoding of NNR codons in eukaryotes.

The recruitment of Wdr5 to its target loci depends on Kat8.

The predominant localization of Linc00173 is in mononuclear macrophage nuclei.

The PDPN gene deactivates the C-type lectin receptor (CLEC-2).


The US health care system can save up to $5 billion if 7% of patients waiting for kidney transplants participate in the optimized national kidney paired donation program.

HSCT-T dosage may not be diagnostic if the onset of symptoms occurs less than 3 hours before AMI.

10% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.

miR-142-5P is a known regulator of raised body temperature.

Risedronate increases risk of vertebral and non-vertebral fractures.

Ethanol stress increases the expression of SRL in bacteria.

Differentiation of progenitor cells to myeloid cells is skewed when insulin signaling is suppressed.

Tumor development occurs in conjunction with suppression of pro-inflammatory cytokines.

T cell receptor /CD3 microdomains are required to induce the immunologic synapse.

Early patent ductus ateriosus (PDA) screening decreases in-hospital mortality.

32% of liver transplantation programs required patients to discontinue methadone treatment in 2001.

Angiotensin converting enzyme inhibitors are associated with decreased risk for functional renal insufficiency.

40mg/day dosage of folic acid and 2mg/day dosage of vitamin B12 does not affect chronic kidney disease (CKD) progression.

Ten percent (10%) of kidney cancers in the UK are attributable to excess weight.

Insulin decreases risk of severe kidney failure.

Risk of cardiovascular events can be cut by a third by using antihypertensive drug therapy among hemodialysis patients.

The effect of Lipopolysaccharides on kidney barrier function is dependent on inflammation levels.

CRP is positively correlated with postoperative mortality following Coronary Artery Bypass Graft (CABG) surgery.

Bone Marrow (BM) transplantation is used to treat acute myeloid leukemia (AML)


The World Health Organization's (WHO) data collection process is biased downward by unequal selection of larger outbreaks.

Upon developing tyrosine-kinase inhibitor resistance, new mutations in epidermal growth factor receptors emerge and cause treatment failure.

Rising temperatures caused by global warming lowers the risk of dengue fever transmission.

The appearance of brown-like or beige cells primarily occurs in visceral fat, not subcutaneous fat.

PCSK9 inhibitors decrease plasma Lp(a) levels.

Stroke patients with prior use of direct oral anticoagulants have a higher risk of in-hospital mortality than stroke patients with prior use of warfarin.

FACT and other histone chaperone(s) compensate for Histone 2A (H2A)-histone 2B (H2B) dimer eviction during the histone exchange process.

Deletion of ATM and Rad3 related protein is not predictive of acute tissue loss.

Polymeal nutrition increases cardiovascular mortality.

Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 encourage West Nile virus replication in cortical neurons.

Rising temperatures caused by global warming increases risk of dengue fever transmission.

Urbanization is an important risk factor related to the transmission of dengue fever.

Sepsis related mortality has risen from 2009 to 2014.

Tuberculosis incidence occurs at higher rates in more sparsely populated areas in the UK.

Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission.

Epidemiological disease burden from noncommunicable diseases is more prevalent in high economic settings.

The innate immune response struggles to remove small numbers of parasites.


The ability of activator E2Fs in preventing cell death is limited to terminally differentiated cells.

Early patent ductus ateriosus (PDA) screening decreases in-hospital mortality.

Active Ly49Q induces neutrophil polarization.

Clathrin stabilizes the spindle fiber apparatus during mitosis.

Expression of oncolytic virus antigens as peptides makes relapse more likely.

Excess gestational weight gain is associated with obesity-related pregnancy outcomes.

Side effects associated with antidepressants lower risk of myocardial infarction.

The Snf1 complex regulates carbon and energy metabolism in baker's yeast (Saccharomyces cerevisiae).

Gastric infection with Helicobacter pylori increases risk of gastric cancer in humans.

Lack of FGF21 in mice leads to atherosclerotic plaque formation.

Differentiated E2f-1, -2, -3 TKO cells in the intestine do not exhibit apoptosis.

Egr2 regulates the homeostasis of B and T cells.

Varying expression levels of EBI2 affect the positioning and migration of B cells.

Mutations in G-Beta protein GNB1 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.

EGR2 is important to myelination of the peripheral nervous system.

Osteocytes have an essential role in G-CSF induced HSPC mobilization.

Egr3 regulates the homeostasis of B and T cells.

In S. cerevisiae, the absence of RNA surveillance pathways reduces sensitivity to high iron conditions.


The amount of publicly available DNA data doubles every 10 months.

Monoclonal antibody targeting of N-cadherin encourages castration resistance.

Overexpressing Cnp1 N-tail variants rescues the temperature-sensitive growth defect of scm3-139.

B3-Galectin decreases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR.

Rising temperatures caused by global warming increases risk of dengue fever transmission.

Including pharmacists in rounding teams does not alter the incidence of adverse drug events (ADEs).

Ethanol stress increases the expression of SRL in bacteria.

The C-type lectin receptor (CLEC-2) rearranges the actin cytoskeleton in dendritic cells to promote efficient motility along stromal surfaces.

Medications to treat obesity have unwanted side effects.

L3MBTL2 binds to H2AK119Ub marked chromatin to form a PRC1 complex.

IFIT1 speeds viral replication by allowing for the proliferation of mis-capped viral RNAs.

53% of perinatal mortality is due to low birth weight.

Sepsis related mortality has risen from 2009 to 2014.

Genes involved in pre-mRNA splicing have a significant impact on genome stability.

For every 1,000 children with cerebral palsy, more than 300 of them are premature or underweight at birth.

Low nucleosome occupancy correlates with high methylation levels across species.

The World Health Organization's (WHO) data collection process is biased downward by unequal selection of larger outbreaks.

De novo assembly of sequence data has fewer specific contigs than unassembled sequence data.

De novo assembly of sequence data has shorter contigs than unassembled sequence data.

Transcription rates in S. cerevisiae range between 7 and 12 kb/min.


The appearance of brown-like or beige cells primarily occurs in visceral fat, not subcutaneous fat.

Reduced levels of lipolysis leads to higher P38 phosphorylation in adipose tissue.

Marmosets have a brain region homologous to Broca's area.

Exercise increases cancer mortality rates among Chinese citizens.

Bariatric surgery leads to positive outcomes in mental health.

Men are more susceptible to death due to pneumonia when compared to women.

In S. cerevisiae, the absence of RNA surveillance pathways causes sensitivity to high iron conditions.

Vitamin D is an important factor in the relationship between calcium and parathyroid hormone.

Post-transcriptional handling of mitochondrial transcripts occurs in mitochondrial RNA granules.

Environmental factors can influence the development of breast cancer.

Ca2+ cycling controls whole-body energy homeostasis in beige fat.

The morphology change from large white adipocytes to small brown adipocytes is a sign of decreased energy expenditure potential in white adipose tissue.

The morphology change from large white adipocytes to small brown adipocytes is a sign of increased energy expenditure potential in white adipose tissue.

Myelin sheaths are lipid-rich cellular structures.

The tissue surrounding the granuloma in an immune cell induces an anti-inflammatory immune response.

Bone marrow cells don't contribute to adult macrophage compartments.

Normal granulomas form in the presence of TNF in Zebrafish.

Normal granulomas form in the absence of TNF in Zebrafish.

Adult tissue-resident macrophages stem from the embryonal yolk sac and fetal liver.


The artifactual C-terminal helix swapping in the StART domain is observed in the Ups1-Mdm35 heterodimer of the StARkin superfamily.

Omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegans.

Aged patients are less susceptible to ischaemia/reperfusion injury.

A deficiency of vitamin B6 decreases blood levels of homocysteine.

Ribosomopathies have a high degree of cell and tissue specific pathology.

RANK-RANKL pathway signalling is linked to development of Aire-expressing medullary thymic epithelial cells.

The C-type lectin receptor (CLEC-2) rearranges the actin cytoskeleton in dendritic cells to promote efficient motility along stromal surfaces.

IL-10 production by monocytes inhibits CD4 + T cell response.

Bariatric surgery reduces colorectal cancer.

In British Men, haplogroup I increases risk of cardiovascular disease by 50%.

The PPR MDA5 has twenty N-terminal CARD domains.

Emodin forms hydrogen bonds with residues involved in PGAM1 substrate binding.

R2D2 stops miRNA production by increasing the selectivity of Dcr2 for long dsRNA.

mcm 5 s 2 U is required for proper decoding of NNR codons in eukaryotes.

LSD1-positive promoters are associated with RNA polymerase II

Mutations in RIM1 decrease levels of IME1 RNA.

Guanine nucleotide dissociation inhibitor (Rho-GDI) interacts with the p75 NTR death domain

Formation of N-terminal pyroglutamate by glutamine cyclase (GC) competes with NTAQ1 for Nt-Gln substrates.


The combination of physical examinations with C-reactive protein values do not improve the accuracy of radiographic verified pneumonia predictions.

Nuclear transfer from adult human fibroblasts to human oocytes can give rise to blastocysts containing expandable pluripotent cells.

Insulin effects appetite via ventral tegmental neurons.

The most prevalent adverse events to Semaglutide are gastrointestinal.

Genes involved in pre-mRNA splicing have a significant impact on genome stability.

Kir7.1 modulates channel activity by the G protein-coupled melanocortin-4 receptor (MC4R) in the paraventricular nucleus of the hypothalamus.

Pioglitazone use is significantly associated with an increased risk of pancreatic cancer.

Tirasemtiv has no effect on cardiac muscle.

Chemical injury represses transglutaminase 2 activity.

Overexpressing Cnp1 N-tail variants rescues the temperature-sensitive growth defect of scm3-139.

Tuberculosis-induced granulomas express different immune system protein signatures than the surrounding tissue.

Men are more susceptible to death due to pneumonia when compared to women.

Women are more susceptible to death due to pneumonia when compared to men.

There was an estimated 30 million cases of pneumonia in young children worldwide in 2010.

Antiretroviral therapy increases rates of tuberculosis across a broad range of CD4 strata.

The World Health Organization's (WHO) data collection process is biased downward by unequal selection of larger outbreaks.

Primary cervical cytology screening with HPV detection has higher longitudinal sensitivity to detect severe cervical intraepithelial neoplasia than conventional cytology.

Risk of cardiovascular events can be cut by a third by using antihypertensive drug therapy among hemodialysis patients.

High levels of CRP lead to a higher risk of exacerbations in chronic obstructive pulmonary disease (COPD).


The composition of myosin-II isoform switches from the A isoform to the B isoform during hematopoietic differentiation.

Active Ly49Q induces neutrophil polarization.

Upregulation of PD1 causes the downmodulation of Satb1.

Cost effectiveness evaluations based on cRCT data lack external validity.

Destination container port throughput(CPT) is positively related to dengue virus (DENV-1) diffusion in air traffic shipments.

The most prevalent adverse events to Semaglutide are cardiovascular.

Vitamin D deficiency effects birth weight.

YAP/TAZ is required in intestinal regeneration in mouse models of ulcerative colitis.

Immune complex triggered cell death leads to extracellular release of nuclear DNA.

Intra-cerebroventricular infusion of amyloid-β oligomers increases expression of fibronectin type-III domain-containing protein 5 mRNA in mice hippocampi.

PTEN is a regulator for the transcriptional activity of SRF

Varying expression levels of EBI2 affect the positioning and migration of B cells.

GATA3 regulates cell cycle progression in bone marrow hematopoietic stem cells.

Active H. pylori urease has a polymeric structure consisting of five distinct subunits.

The HSV-2 infection is typically asymptomatic.

B cells go though plasmablast differentiation and antibody production by continuous expression of EBI2.

GATA3 regulates self-renewal capacity in bone marrow hematopoietic stem cells.

Egr3 regulates the homeostasis of B and T cells.

Egr2 regulates the homeostasis of B and T cells.

Mutations in G-Beta protein GNB1 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.


The cytokine receptor which regulates chemotaxis and formation of lymph nodes is involved in production of myeloperoxidase in the left atrium.

Chemical injury represses transglutaminase 2 activity.

The G34R/V mutation does not create a hypomethylated phenotype at the H3K36 histone.

CDK6 shows improved binding to loss-of-function variants of p18 INK4C.

Sympathetic nerve activity is reduced throughout normal pregnancy.

Diabetes remission occurs less in people treated with conventional therapy than in people treated with laparoscopic adjustable gastric banding surgery.

Foxk2 regulates autophagy genes in muscle cells and fibroblast cells.

Incidence of heart failure increased by 10% in women since 1979.

The recruitment of Wdr5 to its target loci depends on Kat8.

BiP is a general endoplasmic reticulum stress marker.

Osteocytes have an essential role in G-CSF induced HSPC mobilization.

AMP-activated protein kinase (AMPK) activation reduces inflammation-related fibrosis in the lungs.

Pro-inflammatory cytokines are up regulated during tumor development.

Cancer cells can stimulate the accumulation of intra-tumoural myeloid-derived suppressor cells by promoting granulocyte colony stimulating factor production.

Klf4 is important for proper myeloid cell differentiation.

Cancer-associated fibroblasts (CAFs) interact with cancer cells to mediate formation and activation of CAFs.

Increased lipolysis leads to higher P38 phosphorylation in adipose tissue.

Reduced levels of lipolysis leads to higher P38 phosphorylation in adipose tissue.

Tumor development occurs in conjunction with upregulation of pro-inflammatory cytokines.