IL-6 signaling plays a major role in atherosclerotic cardiovascular disease.

Varenicline monotherapy is more effective after 26 weeks of treatment compared to combination nicotine replacement therapies with varenicline or bupropion.

V-9302 inhibits antitumor responses by decreasing cell death and oxidative stress.

Pioglitazone use is significantly associated with an increased risk of pancreatic cancer.

Cnn1 recruitment varies with cell cycle timing.

p16INK4A degradation is encoded by CDKN2A.

Removal of H3K9me3 by ectopic expression of other H3K9 demethylases improves reprogramming efficiency in SCNT experiments.

4-PBA treatment raises endoplasmic reticulum stress in response to general endoplasmic reticulum stress markers.

Side effects associated with antidepressants lower risk of myocardial infarction.

The RANK-RANK-Ligand (RANKL) pathway is involved in the development of Aire-expressing medullary thymic epithelial cells (mTECs).

IFIT1 speeds viral replication by allowing for the proliferation of mis-capped viral RNAs.

The minor G allele of FOXO3 up-regulates IL-10.

Repressing IL-18 has negative effects on atherosclerotic lesion composition and progression.

Interleukin-18 plays an important role in the pathogenesis of atherosclerosis.

GATA3 regulates cell cycle progression in bone marrow hematopoietic stem cells.

Toll-like receptor (TLR) signaling is involved in the pathogenesis of human MDS.

LDL cholesterol has a causal role in the development of cardiovascular disease.


ITAM phosphorylation allows for the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).

The minor G allele of FOXO3 is related to less severe symptoms of Crohn's Disease.

CD28 initiates tonic signaling in conventional T cells, which causes an exhaustion phenotype and limited efficiency.

Medications to treat obesity are highly effective.

The proliferative capacity of progenitors is regulated cell-autonomously.

Cellular differentiation of embryonic stem cells is accompanied by changes in replication timing, transcription and nuclear localization.

Expression of oncolytic virus antigens as peptides makes relapse more likely.

In melanoma, anti-CTLA-4 treatment reinvigorates exhausted PD-1+Eomes+CD8 T cells.

Origin gross domestic product(GDP) is negatively related to dengue virus (DENV-1) diffusion in air traffic shipments.

BiP is a general endoplasmic reticulum stress marker.

Activated Cdk5 regulates DNA damage-induced neuronal death.

Major antigen-induced signals from the T cell receptor and secondary signals from costimulatory receptors are required for T cell activation.

CD28 signals regulate trafficking of murine auto-reactive T cells into target tissues.

T cell receptor /CD3 microdomains are required to induce the immunologic synapse.

Foxp3 enables the expression of transcriptional regulators implicated in memory T cell development.

Blocking the interaction between TDP-43 and respiratory complex I proteins ND3 and ND6 prevents TDP-43-induced neuronal loss.

Foxp3 represses the expression of transcriptional regulators implicated in memory T cell development.

B3-Galectin increases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR.

Activated Cdk5 phosphorylates the ATM protein in response to DNA damage.

B3-Galectin decreases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR.


IgA plasma cells that are specific for transglutaminase 2 are scarce in the duodenal mucosa of celiac disease patients when the disease is active.

M. stadtmanae induces ASC speck formation in BlaER1 monocytes.

Side effects associated with antidepressants increases risk of stroke.

Dscam1 acts as a hypervariable pattern-recognition receptor for the immune system.

p16INK4A degradation is  linked to an abnormal wound response caused by the microinvasive step of advanced Oral Potentially Malignant Lesions (OPMLs).

Neutrophils produce IL-1β in response to large particles.

Charcoal shows no benefit for acute paraquat poisoning.

Low expression of miR7a does not repress target genes or exert a biological function in ovaries.

The minor G allele of FOXO3 is related to less severe symptoms of Crohn's Disease.

The deamination of cytidine to uridine on the minus strand of viral DNA can inactivate the viral genome by inducing G-to-A mutations.

Rhythmic expression of Cry1 translates directly into a circadian regulation of cAMP signaling in hepatic glucose metabolism.

A T helper 2 cell (Th2) environment impedes disease development in patients with systemic lupus erythematosus (SLE).

The composition of myosin-II isoform switches from the A isoform to the B isoform during hematopoietic differentiation.

GATA3 regulates self-renewal capacity in bone marrow hematopoietic stem cells.

Mice that lack Interferon-γ or its receptor are highly susceptible to experimental autoimmune myocarditis.

Mutations in G-Beta protein GNB1 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.

Chemical injury represses transglutaminase 2 activity.

Mutant mice lacking SVCT2 have severely reduced ascorbic acid levels in both brain and adrenals.

Gpr124 suppresses BBB breakdown in mouse models of ischemic stroke.


Immune complex triggered cell death leads to extracellular release of nuclear DNA.

Osteocytes have an essential role in G-CSF induced HSPC mobilization.

Surgical treatment is not superior to non-surgical in treating adults with displaced fractures of the proximal humerus.

Anthrax spores are very difficult to dispose once they are dispersed.

Individuals with low serum vitamin D concentrations have decreased risk of multiple sclerosis.

TNFAIP3 is a tumor enhancer in glioblastoma.

Intra-cerebroventricular infusion of amyloid-β oligomers increases expression of fibronectin type-III domain-containing protein 5 mRNA in mice hippocampi.

Patients with panic anxiety show decreased CSF levels of hypocretin.

H.pylori-mediated gastric cancer occurs due to the accumulation of mutations in host epithelial cells.

There is no relation between Erythromycin use and hypertrophic pyloric stenosis.

Stacking is more stable when a purine is present in the +5 position (C1698).

Immune complex triggered cell death leads to sequestration of oxidized mitochondrial DNA.

Oxidative DNA damage activates STING signalling.

The deamination of cytidine to uridine on the minus strand of viral DNA can inactivate the viral genome by inducing G-to-A mutations.

Cellular differentiation of embryonic stem cells is accompanied by changes in replication timing, transcription and nuclear localization.

Nuclear transfer from adult human fibroblasts to human oocytes can give rise to blastocysts containing expandable pluripotent cells.

Mitochondria play a major role in apoptosis.

Activated Cdk5 regulates DNA damage-induced neuronal death.

Oxidative DNA damage inhibits STING signalling.

Neutrophils produce IL-1β in response to large particles.


Immune complex triggered cell death leads to sequestration of oxidized mitochondrial DNA.

B3-Galectin increases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR.

Therapeutics receiving accelerated approval encounter a lower frequency of post-marketing safety events

The risk of breast cancer among parous women decreases with placental weight of pregnancies.

Incidence of heart failure increased by 10% in women since 1979.

Reduced responsiveness to interleukin-2 in regulatory T cells is associated with autoimmune diseases such as Type 1 Diabetes.

Immune responses in immune cells are geographically segregated.

Replacement of OCT4 and SOX2 genes with GATA3 is not capable of reprogramming human cells.

A 100g dose of chloroquine chemoprophylactic regimen results in retinal toxicity after 1 year of weekly intake.

Microcin J25 encourages nucleoside triphosphate (NTP) binding.

Cytochrome c is transferred from cytosol to the mitochondrial intermembrane space during apoptosis.

Elevated cell-free mitochondrial DNA levels are associated with mortality.

Mitochondria play a major role in energy production.

The generation of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells.


Immune responses in immune cells are geographically segregated.

IFIT1 speeds viral replication by allowing for the proliferation of mis-capped viral RNAs.

The cytokine receptor which regulates chemotaxis and formation of lymph nodes is involved in production of myeloperoxidase in the left atrium.

Genomic sequences involved in alternative splicing responsible for Hutchinson-Gilford progeria syndrome (HGPS) are abundant in the ''progerinonly'' allele of Lmna knock-in models.

ITAM phosphorylation allows for the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).

Activator-inhibitor pairs are provided ventrally by Xrl-sizzled.

Incidence of 10/66 dementia is lower than the incidence of DSM-IV dementia.

Folate and vitamin B12 levels influence the association between homocysteine and preeclampsia.

Cost effectiveness evaluations based on cRCT data accurately reflect prices for patients in actual clinical practice.

G-CSF increases the expansion and infiltration of MDSCs into tumors.

Environmentally-induced senescence is mimicked in disease modeling by adding specific molecules to the culture system.

Microglia are an innate immune cell type of the central nervous system.

The innate immune response struggles to remove small numbers of parasites.

Microglia are an innate immune cell type of the peripheral nervous system.

Tuberculosis-induced granulomas express different immune system protein signatures than the surrounding tissue.

The proliferative capacity of neural progenitors differs across species.

Increased flux of microbial products provokes immune responses.

Increased flux of microbial products suppresses immune responses.

The tissue surrounding the granuloma in an immune cell induces an anti-inflammatory immune response.


Improvements in OER catalysts show stable activity over several hundred hours.

Mice that lack Interferon-γ or its receptor are highly susceptible to experimental autoimmune myocarditis.

Oxidative DNA damage activates STING signalling.

The most prevalent adverse events to Semaglutide are cardiovascular.

Mutations in RIM1 raise levels of IME1 RNA.

Diabetes remission occurs less in people treated with conventional therapy than in people treated with laparoscopic adjustable gastric banding surgery.

90% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.

Upregulation of PD1 causes the upregulation of Satb1.

Bariatric surgery leads to positive outcomes in mental health.

Peroxynitrite is required for induction of T cell tolerance.

Rapid phosphotransfer rates are correlated with histidine kinase regulator specificity.

Glucose restriction to 0.05% reduces RLS (replicative life span) by 20-40% in S. cerevisiae.

Replacement of histone H2A with H2A.Z accelerates gene activation in yeasts by destabilizing +1 nucleosomes.

Active H. pylori urease has a polymeric structure consisting of five distinct subunits.

Increased conversion of PGE 2 to PPARy ligand 15-ket-PGE 2 causes accumulation of PGE.

Mitochondria play a major role in energy production.

Oxidative phosphorylation is one of the primary glycometabolic pathways in cells.

The ability of activator E2Fs in preventing cell death is limited to terminally differentiated cells.

Decreased conversion of PGE 2 to PPARy ligand 15-ket-PGE 2 causes accumulation of PGE.


In British Men, haplogroup I decreases risk of cardiovascular disease.

Taxation of sugar-sweetened beverages reduced the incidence rate of type II diabetes in India.

Removal of H3K9me3 improves reprogramming efficiency in human somatic cell nuclear transfer experiments.

61% of colorectal cancer patients are diagnosed with regional or distant metastases.

RANK-RANKL pathway signalling has no known association with development of Aire-expressing medullary thymic epithelial cells.

Ca2+ cycling controls whole-body energy homeostasis in beige fat.

Genes involved in pre-mRNA splicing have a significant impact on genome stability.

Decrease of p62 in prostate tumor stroma results in defective autophagy.

Varenicline monotherapy is more effective after 26 weeks of treatment compared to combination nicotine replacement therapies with varenicline or bupropion.

Elevated cell-free mitochondrial DNA levels are associated with mortality.

In British Men, haplogroup I increases risk of cardiovascular disease by 50%.

Female carriers of the Apolipoprotein E4 (APOE4) allele have decreased risk for dementia.

Female carriers of the Apolipoprotein E4 (APOE4) allele have increased risk for Alzheimer's disease.

Female carriers of the Apolipoprotein E4 (APOE4) allele have longer lifetime exposure to estrogen due to an increased reproductive period.

Female carriers of the Apolipoprotein E4 (APOE4) allele have shorter lifetime exposure to estrogen due to a decreased reproductive period.

Ten percent (10%) of kidney cancers in the UK are attributable to excess weight.

A mutation in HNF4A leads to an increased risk of diabetes by the age of 14 years.

A mutation in HNF4A leads to an increased risk of developing diabetes by the age of 14 years.

Women with a lower birth weight are more likely to develop breast cancer later in life.


In British Men, haplogroup I increases risk of cardiovascular disease by 50%.

BiP is a general endoplasmic reticulum stress marker.

HbA1c consistently overestimates glycemic control in black individuals with Sickle cell trait (SCT).

In pediatric tissue, most T cells are naive T cell emigrants from the thymus.

Bariatric surgery reduces colorectal cancer.

In a naive state, blocking Wingless-Int-1 secretion from mouse embryonic stem cells inhibits self-renewal of the mouse embryonic stem cells.

PKG-la does not have a large impact on expression of spinal long term potentiation in PGK-la knockout mice.

Commelina yellow mottle virus' (ComYMV) genome consists of 2140 baise pairs.

Pioglitazone use is significantly associated with an increased risk of prostate cancer.

Fibroblast Growth Factor is a ligand which signals through receptor tyrosine kinases.

Systemic lupus erythematosus is a risk factor for cardiovascular disease.


In S. cerevisiae, the absence of RNA surveillance pathways causes sensitivity to high iron conditions.

Gastric infection with Helicobacter pylori increases risk of gastric cancer in humans.

Up-regulation of the p53 pathway and related molecular events speeds cancer progression.

DMS3 protein enables Pol V transcription in vivo.

In patients with congenital heart defects, β-blockers significantly improve clinical heart failure outcomes.

Expression of oncolytic virus antigens as peptides makes relapse more likely.

Female carriers of the Apolipoprotein E4 (APOE4) allele have decreased risk for dementia.

Migraine with aura is associated with ischemic stroke.

IgA plasma cells that are specific for transglutaminase 2 are scarce in the duodenal mucosa of celiac disease patients when the disease is active.

Including pharmacists in rounding teams reduces the incidence of adverse drug events (ADEs).

Egr2 regulates the homeostasis of B and T cells.

In S. cerevisiae, the absence of RNA surveillance pathways reduces sensitivity to high iron conditions.

Cytosolic proteins bind to iron-responsive elements on mRNAs coding for TFRC1.

Mitochondria play a trivial role in calcium homeostasis.

A strong bias in the phage genome locations where the spacers were derived has been observed in many CRISPR subtypes that confer the immunity to phage.

The ability of activator E2Fs in preventing cell death is limited to terminally differentiated cells.

Higher plasma levels of I-carnitine, when associated with trimethylamine N-oxide, are negatively correlated with cardiovascular events in humans.

Higher plasma levels of I-carnitine, when associated with trimethylamine N-oxide, are positively correlated with cardiovascular events in humans.

Mitochondria play a major role in energy production.

Ethanol stress increases the expression of IBP in bacteria.


In S. cerevisiae, the absence of RNA surveillance pathways reduces sensitivity to high iron conditions.

Increased microtubule acetylation repairs interference of axonal transport caused by LRRK2 Roc-COR domain mutations.

The risk of breast cancer among parous women decreases with placental weight of pregnancies.

Omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegans.

Rhythmic expression of Cry1 translates directly into a circadian regulation of cAMP signaling in hepatic glucose metabolism.

Major vault protein regulates sorting of tumor suppressive miR-193a into EVs.

Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection increases dissemination of Salmonella Typhimurium from the gut.

Increased vessel density along with a reduction in fibrosis improves the efficacy of chemotherapy treatments.

Tumor development occurs in conjunction with suppression of pro-inflammatory cytokines.

Polymeal nutrition increases cardiovascular mortality.

The mean suicide rate in women is higher after miscarriage than live birth.

A deficiency of folate increases blood levels of homocysteine.


In a naive state, blocking Wingless-Int-1 secretion from mouse embryonic stem cells inhibits self-renewal of the mouse embryonic stem cells.

MafA ubiquitination decreases the recruitment of coavtivator P/CAF by MafA.

Distant CREs are important for transcriptional regulation.

Chinese individuals with TT homozygosity in the MTHFR gene are more vulnerable to strokes caused by low levels of folate intake.

H4 G94P proteins inhibit chromatin assembly, which decreases free histones.

The number of unfertilized oocytes in mated hermaphrodites increases with age.

Mice defective for deoxyribonucleic acid (DNA) polymerase m (polm) reveal increased sensitivity to ionizing radiation (IR).

Mutations in RIM1 decrease levels of IME1 RNA.

Activated Cdk5 phosphorylates the ATM protein in response to DNA damage.

Increased LDL receptors plays a role in the reduction of plasma Lp(a).

Androgenetic haploid mouse embryonic stem cells (ESCs) can be derived and genetically manipulated in vitro.

Human embryonic stem cells give rise to cell types from the outer embryonic germ layer, but not the other two layers.

Cellular differentiation of embryonic stem cells is accompanied by changes in replication timing, transcription and nuclear localization.

Human embryonic stem cells have the capacity to give rise to differentiated progeny representative of all three embryonic germ layers.

Reducing H3k4me3 methylation induces mouse epiblast stem cells to naive pluripotency efficiently.

Activation of the Rac1 homolog CED-10 kills viable cells in SRGP-1 mutant Caenorhabditis elegans.

Human embryonic stem cells give rise to cell types from all three embryonic germ layers.

Foxp3 enables the expression of transcriptional regulators implicated in memory T cell development.

Lack of FGF21 in mice increases life expectancy.


In breast cancer, the loss of myoepithelial cells promotes the transition of ductal carcinoma in situ to invasive carcinoma.

Ethanol stress increases the expression of SRL in bacteria.

PRC1-bound plasmids sediment at a slower rate in unbound plasmids than in sucrose gradients.

Active H. pylori urease has a polymeric structure consisting of five distinct subunits.

Lack of FGF21 in mice leads to reduced lifespan.

In melanoma, anti-CTLA-4 treatment reinvigorates exhausted PD-1+Eomes+CD8 T cells.

Forkhead 0 (fox0) transcription factors are involved in cellular differentiation.

Pseudogene PTENP1 encodes a transcript that regulates PTEN expression.

Over half of the gabonese children with Schimmelpenning-Feuerstein-Mims syndrome (SFM) had a plasma lactate of more than 5mmol/L.

Destination container port throughput(CPT) is negatively related to dengue virus (DENV-1) diffusion in air traffic shipments.

De novo assembly of sequence data has shorter contigs than unassembled sequence data.

In breast cancer, the loss of myoepithelial cells slows the transition of ductal carcinoma in situ to invasive carcinoma.

Many cytokines that are produced by cancer cells also contribute to carcinogenesis.

Cancer-associated fibroblasts (CAFs) interact with cancer cells to mediate formation and activation of CAFs.

Environmental factors can influence the development of breast cancer.

Cancer-associated fibroblasts (CAFs) have no known interaction with cancer cells in the formation and activation of CAFs.

The risk of breast cancer among parous women decreases with placental weight of pregnancies.

Ten percent (10%) of kidney cancers in the UK are attributable to excess weight.

H.pylori-mediated gastric cancer occurs due to the accumulation of mutations in host epithelial cells.

Women with a lower birth weight are more likely to develop breast cancer later in life.


In breast cancer, the loss of myoepithelial cells slows the transition of ductal carcinoma in situ to invasive carcinoma.

HOXB4 is a highly expressed component of cellular secretome from fetal liver cell populations.

IFI16 impedes STING phosphorylation and translocation, resulting in reduced activation of STING.

Blocking the interaction between TDP-43 and respiratory complex I proteins ND3 and ND6 prevents TDP-43-induced neuronal loss.

Deltex has no known interactions with eIF3f.

Nuclear transfer from adult human fibroblasts to human oocytes can give rise to blastocysts containing expandable pluripotent cells.

Klf4 is not required for proper myeloid cell differentiation.

Differentiation of progenitor cells to myeloid cells is skewed upon activation of insulin signaling.

Tuberculosis incidence occurs at higher rates in more sparsely populated areas in the UK.

Cancer-associated fibroblasts (CAFs) are constituents of tumor microenvironments

Cancer cells can stimulate the accumulation of intra-tumoural myeloid-derived suppressor cells by promoting granulocyte colony stimulating factor production.


In chronic viral infections or tumors, peptides that selectively inhibit PTPRS can be utilized to boost insufficient activity of pDCs.

G-CSF increases the expansion and infiltration of MDSCs into tumors.

A 100g dose of chloroquine chemoprophylactic regimen results in retinal toxicity after 5-6 years of weekly intake.

Radioiodine treatment of non-toxic multinodular goitre increases thyroid volume.

Removal of H3K9me3 improves reprogramming efficiency in human somatic cell nuclear transfer experiments.

CDK6 shows improved binding to loss-of-function variants of p18 INK4C.

Reduced phosphorylation of PP2A suppresses HDAC4 dephosphorylation.

Diabetes remission occurs more in people treated with conventional therapy than in people treated with laparoscopic adjustable gastric banding surgery.

Egr3 regulates the homeostasis of B and T cells.

Lysine histone demethylase inhibitor JIB 04 is inactive against KDM5A.

AZT given with ribavirin increases anemia.

PCSK9 inhibitors decrease plasma Lp(a) levels.

CD28 signals regulate trafficking of murine auto-reactive T cells into target tissues.

Activation of PPM1D enhances p53 function.

In melanoma, anti-CTLA-4 treatment reinvigorates exhausted PD-1+Eomes+CD8 T cells.

Major antigen-induced signals from the T cell receptor and secondary signals from costimulatory receptors are required for T cell activation.

The PDPN gene deactivates the C-type lectin receptor (CLEC-2).

Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes fibrosis.

Upregulation of PD1 causes the downmodulation of Satb1.

ITAM phosphorylation allows for the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).


In domesticated populations of Saccharomyces cerevisiae, segmental aneuploidy is very common.

Urbanization is an important risk factor related to the transmission of dengue fever.

TNFAIP3 is a glioblastoma tumor suppressor.

Including pharmacists in rounding teams does not alter the incidence of adverse drug events (ADEs).

Origin gross domestic product(GDP) is negatively related to dengue virus (DENV-1) diffusion in air traffic shipments.

Inhibiting glucose-6-phospate dehydrogenase improves lipogenesis by deactivating LKB1-AMPK signaling.

Helminths interfere with immune system control of coinfections by microbial pathogens 16.

Women with a lower birth weight are more likely to develop breast cancer later in life.

In rhesus macaques, daily subcutaneous injections of tenofovir protects against rectally transmitted simian-human immunodeficiency virus.

Tonic signaling from the scFv is amplified by MyD88/CD40.

ATM and Rad3 related protein have no role in sensing DNA damage.

In domesticated populations of Saccharomyces cerevisiae, segmental aneuploidy occurs infrequently.

Crossover hot spots are found within gene promoters in Saccharomyces cerevisiae.

Inside the body, falciparum parasites reproduce asexually.

Human embryonic stem cells have the capacity to give rise to differentiated progeny representative of all three embryonic germ layers.

Human embryonic stem cells give rise to cell types from the outer embryonic germ layer, but not the other two layers.

A strong bias in the phage genome locations where the spacers were derived has been observed in many CRISPR subtypes that confer the immunity to phage.

Adult tissue-resident macrophages are seeded before birth.

Adult tissue-resident macrophages stem from the embryonal yolk sac and fetal liver.


In domesticated populations of Saccharomyces cerevisiae, segmental aneuploidy occurs infrequently.

Scapular stabilizer exercises are more effective than general exercise therapy in reducing pain and improving function of the shoulder.

Systemic lupus erythematosus is a risk factor for cardiovascular disease.

MafA phosphorylation enhances its ubiquitination.

L3MBTL2 binds to H2AK119Ub marked chromatin to form a PRC1 complex.

Kir7.1 modulates channel activity by the G protein-coupled melanocortin-4 receptor (MC4R) in the paraventricular nucleus of the hypothalamus.

PD-1 triggering on monocytes enhances IL-10 production by monocytes.

Adult tissue-resident macrophages are seeded before birth.

Metastatic colorectal cancer treated with a single agent fluoropyrimidines resulted in similar efficacy and better quality of life when compared with oxaliplatin-based chemotherapy in elderly patients.

The NF-κB essential modulator gene prevents intestinal inflammation by inhibiting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death.

MT binding domain drives amyloid structure formation.

The latent infection of myeloid cells with human cytomegalovirus induces a number of changes in gene expression.


In melanoma, anti-CTLA-4 treatment reinvigorates exhausted PD-1+Eomes+CD8 T cells.

IgA plasma cells that are specific for transglutaminase 2 are scarce in the duodenal mucosa of celiac disease patients when the disease is active.

PRC1-bound plasmids sediment at a slower rate in unbound plasmids than in sucrose gradients.

There is no known interaction between Pioneer factor OCT3/4 and major chromatin remodeling factors.

p75 NTR - associated cell death executor (NADE) interacts with the p75 NTR death domain

Ly49Q directs the organization of neutrophil polarization by regulating membrane raft functions.

In breast cancer, the loss of myoepithelial cells slows the transition of ductal carcinoma in situ to invasive carcinoma.

The risk of cancer rises with level of alcohol consumption.

Mitochondria play a major role in apoptosis.

Chlamydia trachomatis is most prevalent in the UK among individuals in their 50s and 60s.

90% of patients with melanoma and an objective response to PD-1 blockade will experience a progression in their melanoma.

CD28 initiates tonic signaling in conventional T cells, which causes an exhaustion phenotype and limited efficiency.

PCSK9 inhibitors decrease plasma Lp(a) levels.

PD-1 triggering on monocytes enhances IL-10 production by monocytes.

EG7 tumors can be killed by systemic oxaliplatin primed CD8+ T cells from the tumor-draining lymph node cells.

Antiretroviral therapy increases rates of tuberculosis across a broad range of CD4 strata.

HSCT-T dosage may not be diagnostic if the onset of symptoms occurs less than 3 hours before AMI.


In patients with congenital heart defects, β-blockers significantly improve clinical heart failure outcomes.

Incidence of 10/66 dementia is higher than the incidence of DSM-IV dementia.

Glucose restriction to 0.05% reduces RLS (replicative life span) by 20-40% in S. cerevisiae.

Surgical treatment is not superior to non-surgical in treating adults with displaced fractures of the proximal humerus.

Reduction of purity of cytoplasmic membranes isolated from overexpressors is indicated by stronger spots for OmpA in 2D BN-PAGE gels.

PD-1 triggering on monocytes enhances IL-10 production by monocytes.

Transcription factor EB induces transcription of pro-inflammatory cytokines in macrophages infected with Staphylococcus aureus.

The PRDM1 gene, when combined with the PRDM14 gene, plays an important role during primordial germ cell specification.

Increased mobility of retrotransposons is assosciated with mutation and higher tumorigenesis rates.

Increased LDL receptors plays a role in the reduction of plasma Lp(a).

Side effects associated with antidepressants increases risk of stroke.

Taking anti-depresents is associated with a decrease in the Aβ level in the brain of experimental animals.

Side effects associated with antidepressants lower risk of myocardial infarction.

In young and middle-aged adults, current or remote uses of ADHD medications increase the risk of serious cardiovascular events.

Sildenafil worsens erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.

Mice that lack Interferon-γ or its receptor are highly susceptible to experimental autoimmune myocarditis.

Sudden death can occur in patients with orthostatic hypertension without cardiac conduction abnormalities.

Antidepressants reduce the severity of migraines.

Side effects associated with antidepressants do not represent a mortality risk to postmenopausal women.


In pediatric tissue, most T cells are naive T cell emigrants from the thymus.

N348I mutations reduce resistance to nevirapine.

miRNAs enforce homeostasis by suppressing low-level ''leaky'' transcription.

Genomic aberrations of metastases provide information for targeted therapy.

Eilat virus (EILV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in nonhuman primates.

Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes epithelial damage.

Activation of the Rac1 homolog CED-10 kills viable cells in SRGP-1 mutant Caenorhabditis elegans.

4-PBA treatment raises endoplasmic reticulum stress in response to general endoplasmic reticulum stress markers.

The proliferative capacity of neural progenitors differs across species.

B cells go though plasmablast differentiation and antibody production by continuous expression of EBI2.

Approximately 250,000 people are infected with human T-cell lymphotropic virus type 1 in the United Kingdom.

Major antigen-induced signals from the T cell receptor and secondary signals from costimulatory receptors are required for T cell activation.

Type 1 Diabetes is associated with subtle perturbations in T reg development.

CD28 signals regulate trafficking of murine auto-reactive T cells into target tissues.

Lice attenuated SIV vaccines induce a stronger antigen-specific T cell response in lymph node cells.

Reduced responsiveness to interleukin-2 in regulatory T cells is associated with autoimmune diseases such as Type 1 Diabetes.

Androgenetic haploid mouse embryonic stem cells (ESCs) can be derived and genetically manipulated in vitro.

EG7 tumors can be killed by systemic oxaliplatin primed CD8+ T cells from the tumor-draining lymph node cells.

A T helper 2 cell (Th2) environment impedes disease development in patients with systemic lupus erythematosus (SLE).


In rhesus macaques, daily subcutaneous injections of emtricitabine are ineffective at protecting against rectally transmitted simian-human immunodeficiency virus.

ScPif1p has reduced binding ability to G-rich ssDNA compared to non-G-rich ssDNA.

Epidemiological disease burden from noncommunicable diseases is more prevalent in high economic settings.

Insulin decreases risk of severe kidney failure.

Upon viral challenge, influenza-specific memory CD4+ T cells greatly diminish the early production of inflammatory chemokines in the lung.

The DESMOND program demonstrates no significant impact on biochemical outcomes.

The risk of cancer rises with level of alcohol consumption.

Bacteriophagaes MS2 and Qβ are members of the Leviviridae.

VgrG (Tssl) protein punctures membranes by forming a spike at the tip of the tube apparatus.

Post-transcriptional handling of mitochondrial transcripts occurs in mitochondrial RNA granules.

TNFAIP3 is a glioblastoma tumor suppressor.

In rhesus macaques, daily subcutaneous injections of tenofovir protects against rectally transmitted simian-human immunodeficiency virus.

Eilat virus (EILV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in nonhuman primates.

Nonhuman primates are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.

Mice are incapable of producing neutralizing antibodies in reponse to the Chikungunya virus (CHIKV) produced in mosquitos.

Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission.

Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection decreases dissemination of Salmonella Typhimurium from the gut.

Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection increases dissemination of Salmonella Typhimurium from the gut.

A 100g dose of chloroquine chemoprophylactic regimen results in retinal toxicity after 1 year of weekly intake.

Mice that lack Interferon-γ or its receptor are highly susceptible to experimental autoimmune myocarditis.


In rhesus macaques, daily subcutaneous injections of tenofovir protects against rectally transmitted simian-human immunodeficiency virus.

Cancer-associated fibroblasts (CAFs) have no known interaction with cancer cells in the formation and activation of CAFs.

Activator-inhibitor pairs are provided ventrally by Xrl-sizzled.

The ability of activator E2Fs in preventing cell death is limited to terminally differentiated cells.

70% of burn patients are admitted for hospitalization and further treatment after appearing at hospital emergency wards or outpatient clinics.

Deltex interacts with eIF3. There is no known interaction between Deltex and elF3

Primary cervical cytology screening with HPV detection has higher longitudinal sensitivity to detect severe cervical intraepithelial neoplasia than conventional cytology.

Pediatric SCD patients with vaso-occlusive crisis show increased morphine use after breathing 80 ppm iNO for 4 hours.

Over half of the gabonese children with Schimmelpenning-Feuerstein-Mims syndrome (SFM) had a plasma lactate of more than 5mmol/L.

Microglia are an innate immune cell type of the peripheral nervous system.

Omnivores produce less trimethylamine N-oxide from dietary I-carnitine than vegans.

Omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegans.

Sildenafil worsens erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.


In the UK, drowning affects boys and girls equally.

Enhanced early production of inflammatory chemokines damages viral control in the lung.

Including pharmacists in rounding teams does not alter the incidence of adverse drug events (ADEs).

Upregulation of dynein in Drosophila neurons increases the number of microtubule plus-ends growing toward the cell body of each neuron.

The proportion of people with visual difficulty is two times higher in low-income countries than in high-income countries.

Algerian physicians constitue the largest component of sub-Saharan Africa-trained physicians in the United States.

Students who perform poorly in the early years of medical school are at increased risk for professional misconduct later in their careers.

MafA ubiquitination increases the recruitment of coavtivator P/CAF by MafA.

Adult tissue-resident macrophages stem from the embryonal yolk sac and fetal liver.

At least 85% of patients exposed to radiation have activated markers of myofibroblasts.

Chlamydia trachomatis is most prevalent in the UK among sexually-experienced individuals aged 16 to 24.

Tuberculosis incidence occurs at higher rates in more sparsely populated areas in the UK.

There was an estimated 30 million cases of pneumonia in young children worldwide in 2010.

The mean suicide rate in women is lower after miscarriage than live birth.

The mean suicide rate in women is higher after miscarriage than live birth.

10% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.

90% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.

The peak incidence of fractures occurs in toddlers.

Chlamydia trachomatis is most prevalent in the UK among individuals in their 50s and 60s.


In transgenic mice harboring green florescent protein under the control of the Sox2 promoter, more than 50 percent of the cells with green florescent colocalize with cell proliferation markers.

There is a relation between Erythromycin use and hypertrophic pyloric stenosis.

H4 G94P proteins induce degradation of free histones via Rad53-dependent mechanisms.

IL-10 production by monocytes inhibits CD4 + T cell response.

The DESMOND program demonstrates no significant impact on lifestyles outcomes.

Inhibiting focal adhesion formation enables cells to convert mechanical strain into eventual scarring.

The innate immune response struggles to remove small numbers of parasites.

Deltex interacts with eIF3. There is no known interaction between Deltex and elF3

Human embryonic stem cells give rise to cell types from the outer embryonic germ layer, but not the other two layers.

1 in 5 million in UK have abnormal PrP positivity.

General exercise therapy is more effective than scapular stabilizer exercises in reducing pain and improving function of the shoulder.

Replacement of OCT4 and SOX2 genes with GATA3 has the ability to reprogram human cells.

Replacement of OCT4 and SOX2 genes with GATA3 is not capable of reprogramming human cells.

Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes fibrosis.

The minor G allele of FOXO3 up-regulates IL-10.

Cytosolic proteins bind to iron-responsive elements on mRNAs coding for TFRC1.

Foxk2 regulates autophagy genes in muscle cells and fibroblast cells.

The recruitment of Wdr5 to its target loci depends on Kat8.

In S. cerevisiae, the absence of RNA surveillance pathways reduces sensitivity to high iron conditions.


In young and middle-aged adults, current or remote uses of ADHD medications increase the risk of serious cardiovascular events.

The DdrB protein from Deinococcus radiodurans functions as a pentamer.

HIV trans-activator protein (TAT) effectively transports large and small molecules across cellular membranes into larger populations of neurons.

Varying expression levels of EBI2 affect the positioning and migration of B cells.

Upregulation of PD1 causes the upregulation of Satb1.

Integrated care is successful at tackling multiple comorbidities.

The tip of the inner tube of the toxic type VI secretion system (T6SS) antibacterial effector in Escherichia coli (E. coli) is decorated with VgrG and PAAR proteins.

PrimPol degrades short DNA replication intermediates on the leading strand during DNA replication.

The PRDM1 gene is a key determinant of primordial germ cells.

Glycan adaptation involves insertion-deletion events.

Cholesterol loading induces KLF4 expression in VSMCs, resulting in the expression of pro-inflammatory cytokines.

Side effects associated with antidepressants increases risk of stroke.

Side effects associated with antidepressants do not represent a mortality risk to postmenopausal women.

Side effects associated with antidepressants lower risk of myocardial infarction.

Antidepressants increase the severity of migraines.

Antidepressants reduce the severity of migraines.

In patients with congenital heart defects, β-blockers significantly improve clinical heart failure outcomes.

The most prevalent adverse events to Semaglutide are cardiovascular.

Risk of cardiovascular events can be cut by a third by using antihypertensive drug therapy among hemodialysis patients.

Medications to treat obesity have unwanted side effects.


Incidence of 10/66 dementia is higher than the incidence of DSM-IV dementia.

Concentrations of SNV and CNV in stem-cell regulatory elements and binding sites of transcription factors in iPSC-lines are distinct from their founding cells.

Urbanization is an important risk factor related to the transmission of dengue fever.

Rising temperatures caused by global warming increases risk of dengue fever transmission.

Mutant mice lacking SVCT2 have severely reduced ascorbic acid levels in both brain and adrenals.

Exercise increases cancer mortality rates among Chinese citizens.

Inside the body, falciparum parasites reproduce asexually.

It is not proven that moderate consumption of candy and chocolate reduces the risk of cardiovascular disease (CVD) specifically.

Systemic immunosuppressive (IS) therapy increases the chance of cancer mortality in patients with inflammatory eye disease (IED)

aPKCz causes tumour suppression by affecting glutamine metabolism.

The G34R/V mutation does not create a hypomethylated phenotype at the H3K36 histone.

Incidence of 10/66 dementia is lower than the incidence of DSM-IV dementia.

Asymptomatic visual impairment screening in elderly populations leads to improved vision.

Individuals with Alzheimers who participate in six months of physical activity improve cognitive function for up to 18 months.

Female carriers of the Apolipoprotein E4 (APOE4) allele have decreased risk for dementia.

Headaches are correlated with cognitive impairment.

90% of patients with melanoma and an objective response to PD-1 blockade will experience a progression in their melanoma.

Physical activity does not improve cognitive function in individuals with Alzheimers.

Female carriers of the Apolipoprotein E4 (APOE4) allele have increased risk for Alzheimer's disease.

Chlamydia trachomatis is most prevalent in the UK among individuals in their 50s and 60s.


Incidence of 10/66 dementia is lower than the incidence of DSM-IV dementia.

p16INK4A degradation is encoded by CDKN2A.

Normal granulomas form in the absence of TNF in Zebrafish.

Emodin forms hydrogen bonds with residues involved in PGAM1 substrate binding.

Sympathetic nerve activity is reduced throughout normal pregnancy.

RANK-RANKL pathway signalling has no known association with development of Aire-expressing medullary thymic epithelial cells.

Patients with microcytosis and higher erythrocyte count are more vulnerable to severe malarial anaemia when infected with Plasmodium falciparum.

Bariatric surgery reduces colorectal cancer.

Tonic signaling from the scFv prevents constitutive stimulation.

Hypocretin neurones suppress panicprone state in rats.


Incidence of heart failure increased by 10% in women since 1979.

Rapamycin increases the concentration of triacylglycerols in fruit flies.

IgA plasma cells that are specific for transglutaminase 2 are scarce in the duodenal mucosa of celiac disease patients when the disease is active.

Adult tissue-resident macrophages are seeded before birth.

Human embryonic stem cells give rise to cell types from the outer embryonic germ layer, but not the other two layers.

Active caspase-11 participate in regulating phagosome-lysosome fusion.

Differentiation of progenitor cells to myeloid cells is skewed upon activation of insulin signaling.

Guanine nucleotide dissociation inhibitor (Rho-GDI) interacts with the p75 NTR death domain

N348I mutations reduce resistance to nevirapine.

Adult tissue-resident macrophages possess a self-renewing capacity.

Ultrasound guidance significantly reduces the number of traumatic procedures when attempting needle insertion.

The mean suicide rate in women is higher after miscarriage than live birth.

The mean suicide rate in women is lower after miscarriage than live birth.

90% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.

10% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.

The risk of breast cancer among parous women decreases with placental weight of pregnancies.

Sepsis related mortality has risen from 2009 to 2014.

Incidence of sepsis has fallen substantially from 2009 to 2014.

Women with a lower birth weight are more likely to develop breast cancer later in life.

53% of perinatal mortality is due to low birth weight.


Incidence of sepsis has fallen substantially from 2009 to 2014.

ITAM phosphorylation allows for the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).

Origin gross domestic product(GDP) is negatively related to dengue virus (DENV-1) diffusion in air traffic shipments.

The most prevalent adverse events to Semaglutide are gastrointestinal.

taa1 tar1 tar2 triple mutants in Arabidopsis do not make root meristem during embryogenesis.

Physical activity does not improve cognitive function in individuals with Alzheimers.

Taxation of sugar-sweetened beverages reduced the incidence rate of type II diabetes in India.

Foxp3 enables the expression of transcriptional regulators implicated in memory T cell development.

Cardiac tissue-resident macrophages directly contribute to electrical activity.

Toll-like receptor (TLR) signaling is involved in the pathogenesis of human MDS.

The minor G allele of FOXO3 is related to less severe symptoms of Crohn's Disease.

Sepsis related mortality has remained stable between 2009-2014.

There was an estimated 30 million cases of pneumonia in young children worldwide in 2010.

Tuberculosis incidence occurs at higher rates in more sparsely populated areas in the UK.


Including pharmacists in rounding teams does not alter the incidence of adverse drug events (ADEs).

Monoclonal antibody targeting of N-cadherin encourages metastasis.

7-day-old adult Caenorhabditis elegans exhibit approximately 5% of the learning capacity seen in 1-day old adults.

Neutrophil extracellular trap (NET) antigens may contain the targeted autoantigens PR3 and MPO.

Oxidative DNA damage inhibits STING signalling.

Citrullinated proteins externalized in neutrophil extracellular traps act indirectly to perpetuate the inflammatory cycle via induction of autoantibodies.

Genes involved in pre-mRNA splicing have a significant impact on genome stability.

Antimicrobial agents are less effective due to the pressure of antimicrobial usage.

Pyridostatin decreases telomere fragility in BRCA2-deficient cells.

Ethanol stress increases the expression of PSP in bacteria.

Including pharmacists in rounding teams reduces the incidence of adverse drug events (ADEs).

Pharmacist attendance at ward rounds increases adverse events in wards.

Pharmacist attendance at ward rounds reduces adverse events in wards.

Assessing treatment adherence is more beneficial to clinical practice than measuring routine outcomes.

Measuring routine outcomes is more beneficial to clinical practice than assessing treatment adherence.

Risk of cardiovascular events can be cut by a third by using antihypertensive drug therapy among hemodialysis patients.

In young and middle-aged adults, current or remote uses of ADHD medications increase the risk of serious cardiovascular events.

The most prevalent adverse events to Semaglutide are cardiovascular.

Cost effectiveness evaluations based on cRCT data accurately reflect prices for patients in actual clinical practice.


Including pharmacists in rounding teams reduces the incidence of adverse drug events (ADEs).

Ribosomal protein (RP) expression is controlled in part by stress-activated regulators.

Human embryonic stem cells have the capacity to give rise to differentiated progeny representative of all three embryonic germ layers.

ScPif1p has higher binding ability to G-rich ssDNA than to non-G-rich ssDNA.

The PRDM1 gene is a key determinant of primordial germ cells.

Mutations in RIM1 raise levels of IME1 RNA.

Excess gestational weight gain is associated with obesity-related pregnancy outcomes.

The composition of myosin-II isoform switches from the A isoform to the B isoform during hematopoietic differentiation.

Adult tissue-resident macrophages stem from the embryonal yolk sac and fetal liver.

Cytochrome c is transferred from cytosol to the mitochondrial intermembrane space during apoptosis.

De novo assembly of sequence data has shorter contigs than unassembled sequence data.

Diabetic patients with acute coronary syndrome experience decreased short-term and long-term risk for bleeding events.


Increase of p62 in prostate tumor stroma results in defective autophagy.

The PRDM1 gene is a key determinant of primordial germ cells.

Over half of the gabonese children with Schimmelpenning-Feuerstein-Mims syndrome (SFM) had a plasma lactate of more than 5mmol/L.

Intake of folic acid (FA) and vitamin B6 (VB6) reduces levels of homocysteine.

Splenomegaly is observed in knockin mouse lacking the SHP-2 MAPK pathway.

Genomic aberrations of metastases provide information for targeted therapy.

Flexible molecules experience less steric hindrance in the tumor microenviroment than rigid molecules.

In the UK, drowning affects boys and girls equally.

A diminished ovarian reserve does not solely indicate infertility in an a priori non-infertile population.

The US health care system can save up to $5 billion if 7% of patients waiting for kidney transplants participate in the optimized national kidney paired donation program.

Decrease of p62 in prostate tumor stroma results in defective autophagy.

Taking 400mg of α-tocopheryl acetate does not prevent prostate cancer.

Pioglitazone use is not associated with an increased risk of prostate cancer.

Pioglitazone use is significantly associated with an increased risk of prostate cancer.

Taking 400mg of α-tocopheryl acetate in combination with vitamin C reduces the risk of prostate cancer.

Activation of PPM1D enhances p53 function.

Upregulation of PD1 causes the upregulation of Satb1.

Reduced levels of lipolysis leads to higher P38 phosphorylation in adipose tissue.

Upregulation of PD1 causes the downmodulation of Satb1.


Increased LDL receptors plays a role in the reduction of plasma Lp(a).

Lack of FGF21 in mice increases life expectancy.

Antimicrobial agents are less effective due to the pressure of antimicrobial usage.

Systemic lupus erythematosus is a risk factor for cardiovascular disease.

Moderate consumption of candy and chocolate reduces the risk of cardiovascular disease (CVD).

Type 1 Diabetes is associated with subtle perturbations in T reg development.

Microcin J25 inhibits nucleoside triphosphate (NTP) binding.

Vaccinating the gastrointestinal tract induces protection of rectal and vaginal mucosa.

Asymptomatic visual impairment screening in elderly populations leads to improved vision.

C2 works synergistically with A-769662 to activate dephosphorylated AMPK.

PCSK9 inhibitors decrease plasma Lp(a) levels.

LDL cholesterol has a causal role in the development of cardiovascular disease.

Increased conversion of PGE 2 to PPARy ligand 15-ket-PGE 2 causes accumulation of PGE.

Decreased conversion of PGE 2 to PPARy ligand 15-ket-PGE 2 causes accumulation of PGE.

AMP-activated protein kinase (AMPK) activation reduces inflammation-related fibrosis in the lungs.

Inhibiting glucose-6-phospate dehydrogenase improves lipogenesis by deactivating LKB1-AMPK signaling.

The density of cytokine receptor bearing cells has no effect on the distance over which cytokines act.

Depletion of nitric oxide is responsible for vasospasm.

High levels of CRP lead to a higher risk of exacerbations in chronic obstructive pulmonary disease (COPD).


Increased conversion of PGE 2 to PPARy ligand 15-ket-PGE 2 causes accumulation of PGE.

B3-Galectin increases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR.

Taking 400mg of α-tocopheryl acetate in combination with vitamin C reduces the risk of prostate cancer.

Mouse models can be generated using "artificial spermatids."

Increased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm.

ART has no effect on the infectiveness of HIV-positive people.

Bariatric surgery leads to negative outcomes in mental health.

Active caspase-11 participate in regulating phagosome-lysosome fusion.

Pediatric SCD patients with vaso-occlusive crisis show increased morphine use after breathing 80 ppm iNO for 4 hours.

British female students are bullied more than British male students.

PKG-la does not have a large impact on expression of pain hypersensitivity in PGK-la knockout mice.

PGE 2 suppresss intestinal tumor growth by altering the expression of tumor suppressing and DNA repair genes.

Reduced phosphorylation of PP2A increases HDAC4 dephosphorylation by enhancing PP2A-HDAC4 interaction.

Reduced phosphorylation of PP2A suppresses HDAC4 dephosphorylation.

There is no increased risk of hypospadias with clomiphene.


Increased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm.

Prescribed exercise training improves quality of life.

Pyridostatin decreases telomere fragility in BRCA2-deficient cells.

The tissue surrounding the granuloma in an immune cell induces an anti-inflammatory immune response.

The appearance of brown-like or beige cells primarily occurs in visceral fat, not subcutaneous fat.

Interleukin-18 plays an important role in the pathogenesis of atherosclerosis.

Walking in traffic areas in London improves lung function in elderly adults.

Increase of p62 in prostate tumor stroma results in defective autophagy.

Persistor cells are one reason for incomplete responses to Tyrosine kinase inhibitor (TKI) therapy in cancer patients.

Birth-weight is negatively associated with breast cancer.

CD44v6 is not associated with constitutive and reprogrammed cancer stem cells driving cancer metastasis.

Decreased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm.

Ambulatory blood pressure monitoring is inaccurate at diagnosing hypertension.

Sudden death can occur in patients with orthostatic hypertension without cardiac conduction abnormalities.

CRP is positively correlated with postoperative mortality following Coronary Artery Bypass Graft (CABG) surgery.

Sudden death can occur in patients with complex ventricular arrhythmias.

Diabetic patients with acute coronary syndrome experience decreased short-term and long-term risk for bleeding events.

Noninvasive positive pressure ventilation is not predictive of acute respiratory failure after solid organ transplantation.


Increased flux of microbial products provokes immune responses.

Toll-like receptor (TLR) signaling is involved in the pathogenesis of human MDS.

Intake of folic acid (FA) and vitamin B6 (VB6) increases levels of homocysteine.

Increased microtubule acetylation worsens interference of axonal transport caused by LRRK2 Roc-COR domain mutations.

Patients with panic anxiety show decreased CSF levels of hypocretin.

The proliferative capacity of neural progenitors differs across species.

Pseudoknots are not evolutionarily conserved in most eukaryotes.

The risk of cancer rises with level of alcohol consumption.

APOE4 expression in iPSC-derived neurons results in decreased tau phosphorylation.

Oxidative DNA damage activates STING signalling.

Men are more susceptible to death due to pneumonia when compared to women.

Increased flux of microbial products suppresses immune responses.

Antimicrobial agents are more effective due to the pressure of antimicrobial usage.

Antimicrobial agents are less effective due to the pressure of antimicrobial usage.

The innate immune response struggles to remove small numbers of parasites.

The tissue surrounding the granuloma in an immune cell induces an anti-inflammatory immune response.

Chronic HIV stimulation of B cells leads to the premature exhaustion of B cells.

Tuberculosis-induced granulomas express different immune system protein signatures than the surrounding tissue.

Immune responses in immune cells are geographically segregated.

Enhanced early production of inflammatory chemokines damages viral control in the lung.


Increased flux of microbial products suppresses immune responses.

Albendazole is used to treat soil-transmitted helminths.

Inhibiting focal adhesion formation enables cells to convert mechanical strain into eventual scarring.

A mutation in HNF4A leads to an increased risk of diabetes by the age of 14 years.

Addition of BMP4, activin A, CHIR99021, and SU504 to reprogramming fibroblasts generates, expands and maintains cardiovascular progenitor cells (CPCs)

Sympathetic nerve activity is reduced throughout normal pregnancy.

Chronic HIV stimulation of B cells leads to the premature exhaustion of B cells.

Aggravated inflammation is dependent on NLRP3 inflammasome activation.

Women with a lower birth weight are more likely to develop breast cancer later in life.

Pyridostatin reduces proliferation of homologous recombination - defective cells.

Nonhuman primates are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.


Increased lipolysis leads to higher P38 phosphorylation in adipose tissue.

The minor G allele of FOXO3 is related to less severe symptoms of Crohn's Disease.

Integrated care is successful at tackling multiple comorbidities.

Toll-like receptor (TLR) signaling is involved in the pathogenesis of human MDS.

H4 G94P proteins inhibit chromatin assembly, which decreases free histones.

A diminished ovarian reserve does not solely indicate infertility in an a priori non-infertile population.

Bone Marrow (BM) transplantation is used to treat acute myeloid leukemia (AML)

The ability of activator E2Fs in preventing cell death is limited to terminally differentiated cells.

Bariatric surgery reduces colorectal cancer.

CDK6 shows improved binding to loss-of-function variants of p18 INK4C.

KLF4 is necessary for VSMCs to gain genetic characteristics of other cell types within atherosclerotic lesions.

Reduced levels of lipolysis leads to higher P38 phosphorylation in adipose tissue.

Inhibiting glucose-6-phospate dehydrogenase improves lipogenesis by deactivating LKB1-AMPK signaling.

AMP-activated protein kinase (AMPK) activation reduces inflammation-related fibrosis in the lungs.

Chenodeoxycholic acid treatment increases brown adipose tissue activity.

The M2-phenotype in brown adipose tissue macrophages increases brown adipose tissue thermogenic activity.

The morphology change from large white adipocytes to small brown adipocytes is a sign of increased energy expenditure potential in white adipose tissue.

The morphology change from large white adipocytes to small brown adipocytes is a sign of decreased energy expenditure potential in white adipose tissue.

Chenodeoxycholic acid treatment decreases brown adipose tissue activity.

APOE4 expression in iPSC-derived neurons results in decreased tau phosphorylation.


Increased microtubule acetylation exacerbates LRRK2 Roc-COR domain mutation induced locomotor deficits.

Inhibiting glucose-6-phospate dehydrogenase improves lipogenesis by deactivating LKB1-AMPK signaling.

Mice lacking Sirt1 in Sf1-expressing neurons are immune to diet-induced obesity and insulin resistance.

The one-child policy has created a hospitable environment for female infants.

Incidence of sepsis has fallen substantially from 2009 to 2014.

Measuring routine outcomes is more beneficial to clinical practice than assessing treatment adherence.

Excess gestational weight gain is associated with obesity-related pregnancy outcomes.

Notch signaling occurs between tumor cells and stromal cells.

Increased microtubule acetylation worsens interference of axonal transport caused by LRRK2 Roc-COR domain mutations.

Pharmacist attendance at ward rounds increases adverse events in wards.

Nonhuman primates are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.

Increased microtubule acetylation repairs interference of axonal transport caused by LRRK2 Roc-COR domain mutations.

Gpr124 suppresses BBB breakdown in mouse models of ischemic stroke.

Activated Cdk5 phosphorylates the ATM protein in response to DNA damage.

ATM and Rad3 related protein have no role in sensing DNA damage.

Deletion of ATM and Rad3 related protein leads to acute tissue loss.

Gpr124 increases BBB breakdown in mouse models of ischemic stroke.

ATM and Rad3 related protein are critical for sensing DNA damage.

CD28 initiates tonic signaling in conventional T cells, which causes an exhaustion phenotype and limited efficiency.


Increased microtubule acetylation repairs interference of axonal transport caused by LRRK2 Roc-COR domain mutations.

Female carriers of the Apolipoprotein E4 (APOE4) allele have decreased risk for dementia.

Replacement of OCT4 and SOX2 genes with GATA3 has the ability to reprogram human cells.

RUNX1 is downregulated or mutated in TLX1 T-ALL.

M. stadtmanae induces ASC speck formation in BlaER1 monocytes.

90% of patients with melanoma and an objective response to PD-1 blockade will experience a progression in their melanoma.

MafA ubiquitination decreases the recruitment of coavtivator P/CAF by MafA.

Active caspase-11 participate in regulating phagosome-lysosome fusion.

Major vault protein regulates sorting of tumor suppressive miR-193a into EVs.

PrimPol generates short DNA replication intermediates on the leading strand during DNA replication.

L3MBTL2 binds to H2AK119Ub marked chromatin to form a PRC1 complex.

ITAM phosphorylation allows for the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).

B3-Galectin decreases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR.


Increased microtubule acetylation worsens interference of axonal transport caused by LRRK2 Roc-COR domain mutations.

The morphology change from large white adipocytes to small brown adipocytes is a sign of decreased energy expenditure potential in white adipose tissue.

The origin of the CRF01_1b2k protein occurred between 1923 and 1956.

siRNA knockdown of A20 slows tumor progression in an in vivo murine xenograft model.

Bariatric surgery leads to positive outcomes in mental health.

Albendazole is used to treat soil-transmitted helminths.

Folate and vitamin B12 levels influence the association between homocysteine and preeclampsia.

Genetic deficiency of mast cells leads to decreased weight gain in a mouse model of diet-induced obesity.

In transgenic mice harboring green florescent protein under the control of the Sox2 promoter, more than 50 percent of the cells with green florescent colocalize with cell proliferation markers.

Transplanted human glial progenitor cells can mature in their host animal.

CD28 signals regulate trafficking of murine auto-reactive T cells into target tissues.


Increased mobility of retrotransposons does not lead to mutation and higher tumorigenesis rates.

The PRDM1 gene is a key determinant of primordial germ cells.

Ambulatory blood pressure monitoring is inaccurate at diagnosing hypertension.

Physical activity level is associated with the difference in maximal oxygen consumption between black and white youth.

Women with a lower birth weight are more likely to develop breast cancer later in life.

Bariatric surgery reduces colorectal cancer.

Having a main partner improves HIV outcomes.

Patients in stable partnerships progress from HIV to death at the same rate as patients not in partnerships.

N348I mutations cause resistance to nevirapine.

Upregulation of dynein in Drosophila neurons increases the number of microtubule plus-ends growing toward the cell body of each neuron.

Neutrophils produce IL-1β in response to large particles.

Increased mobility of retrotransposons is assosciated with mutation and higher tumorigenesis rates.

Up-regulation of the p53 pathway and related molecular events speeds cancer progression.

Genes involved in pre-mRNA splicing have a significant impact on genome stability.

siRNA knockdown of A20 accelerates tumor progression in an in vivo murine xenograft model.

siRNA knockdown of A20 slows tumor progression in an in vivo murine xenograft model.

Carriers of HNF4A mutations are at reduced risk for diabetes.

The generation of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells.

Understanding epigenetic regulation of replication is essential for the reational design of episomally replicating vectors.

The removal of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells.


Increased mobility of retrotransposons is assosciated with mutation and higher tumorigenesis rates.

A diminished ovarian reserve is a very strong indicator of infertility, even in an a priori non-infertile population.

B3-Galectin decreases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR.

Forkhead 0 (fox0) transcription factors are involved in cellular differentiation.

Dexamethasone increases risk of postoperative bleeding.

Cardiac tissue-resident macrophages directly contribute to electrical activity.

Healthy volunteers exhibit rapid and transient increase of cellular ATP after being bolus-injected with fructose.

Ethanol stress increases the expression of IBP in bacteria.

The origin of the CRF01_1b2k protein occurred between 1923 and 1956.

A mutation in HNF4A leads to an increased risk of developing diabetes by the age of 14 years.

Homozygous deletion of murine Sbds gene from osterix-expressing mesenchymal stem and progenitor cells (MPCs) induces oxidative stress.


Increased purity of cytoplasmic membranes isolated from overexpressors is indicated by stronger spots for OmpF in 2D BN-PAGE gels.

Egr3 regulates the homeostasis of B and T cells.

BRCA 1 mutation carriers' risk of breast and ovarian cancer depends on where the mutation is located.

Fibroblast Growth Factor is a ligand which signals through receptor tyrosine kinases.

Intake of folic acid (FA) and vitamin B6 (VB6) increases levels of homocysteine.

Rising temperatures caused by global warming increases risk of dengue fever transmission.

Nigerian physicians constitue the largest component of sub-Saharan Africa-trained physicians in the United States.

Mice defective for deoxyribonucleic acid (DNA) polymerase m (polm) fail to reveal increased sensitivity to ionizing radiation (IR).

Sildenafil worsens erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.

Angiotensin converting enzyme inhibitors are associated with decreased risk for functional renal insufficiency.

The deamination of cytidine to uridine on the minus strand of viral DNA can inactivate the viral genome by inducing G-to-A mutations.

Reduction of purity of cytoplasmic membranes isolated from overexpressors is indicated by stronger spots for OmpF in 2D BN-PAGE gels.

Reduction of purity of cytoplasmic membranes isolated from overexpressors is indicated by stronger spots for OmpA in 2D BN-PAGE gels.

Intramembrane cleavage by signal peptide peptidase aids in the degradation of proteins with a complex membrane orientation.

Lamins have no effect on nuclear membrane structure maintenance.

The microtubule-dependent delivery and secretion of matrix metalloproteases (MMPs) is partially responsible for the disassembly of adhesion sites.

Broadly HIV-1 Neutralizing Antibodies (bnAb) 10EB have no affinity for phospholipids.

Many transmembrane receptors transmit signals by long-range conformational changes in the association of alpha-helices across the plasma membrane.

PRC1-bound plasmids sediment at a slower rate in unbound plasmids than in sucrose gradients.


Increased vessel density along with a reduction in fibrosis improves the efficacy of chemotherapy treatments.

There is no known interaction between Pioneer factor OCT3/4 and major chromatin remodeling factors.

During the primary early antibody response activated B cells migrate toward the inner-and outer follicular areas where oxysterol accumulation is generated by stromal cells.

Primary cervical cytology screening with HPV detection has higher longitudinal sensitivity to detect severe cervical intraepithelial neoplasia than conventional cytology.

Risedronate increases risk of vertebral and non-vertebral fractures.

The predominant localization of Linc00173 is in mononuclear macrophage nuclei.

IL-10 production by monocytes inhibits CD4 + T cell response.

The innate immune response struggles to remove small numbers of parasites.

The G34R/V mutation creates a hypomethylated phenotype at the H3K36 histone.

Mutations in RIM1 raise levels of IME1 RNA.

Two variants of chromosome 6q21 are associated with radiation therapy-induced second malignancies in pediatric Hodgkin lymphoma patients.

G-CSF increases the expansion and infiltration of MDSCs into tumors.

Cancer-associated fibroblasts (CAFs) interact with cancer cells to mediate formation and activation of CAFs.

Cancer-associated fibroblasts (CAFs) have no known interaction with cancer cells in the formation and activation of CAFs.

AMP-activated protein kinase (AMPK) activation reduces inflammation-related fibrosis in the lungs.

Cancer-associated fibroblasts (CAFs) are constituents of tumor microenvironments

Inhibiting focal adhesion formation increases the rate at which cells convert mechanical strain into inflammation and fibrosis.

The cytokine receptor which regulates chemotaxis and formation of lymph nodes is involved in production of myeloperoxidase in the left atrium.

The tissue surrounding the granuloma in an immune cell induces an anti-inflammatory immune response.

In breast cancer, the loss of myoepithelial cells slows the transition of ductal carcinoma in situ to invasive carcinoma.


Individuals with Alzheimers who participate in six months of physical activity improve cognitive function for up to 18 months.

Patients with common epithelial cancers  are more likely to have an emergency event as their first hospital admission if they live in resource-deprived areas.

Pioneer factor OCT3/4 interacts with major chromatin remodeling factors.

The HSV-2 infection is typically asymptomatic.

The minor G allele of FOXO3 up-regulates IL-10.

Overexpressing Cnp1 N-tail variants rescues the temperature-sensitive growth defect of scm3-139.

Reduction of Rpl38 alters the composition of the Hox gene mRNAs translation in mice without lowering overall protein synthesis.

Increased conversion of PGE 2 to PPARy ligand 15-ket-PGE 2 causes accumulation of PGE.

Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission.

4-PBA treatment decreases endoplasmic reticulum stress in response to general endoplasmic reticulum stress markers.

taa1 tar1 tar2 triple mutants in Arabidopsis do not make root meristem during embryogenesis.

Physical activity does not improve cognitive function in individuals with Alzheimers.

Headaches are correlated with cognitive impairment.

Female carriers of the Apolipoprotein E4 (APOE4) allele have increased risk for Alzheimer's disease.

Asymptomatic visual impairment screening in elderly populations leads to improved vision.

Incidence of 10/66 dementia is lower than the incidence of DSM-IV dementia.

Incidence of 10/66 dementia is higher than the incidence of DSM-IV dementia.

In young and middle-aged adults, current or remote uses of ADHD medications increase the risk of serious cardiovascular events.

Female carriers of the Apolipoprotein E4 (APOE4) allele have decreased risk for dementia.

Nonhypertensive people who are 55 years old have a 90% chance of developing hypertension during their lifetime.


Individuals with low serum vitamin D concentrations have decreased risk of multiple sclerosis.

Lack of FGF21 in mice increases life expectancy.

Deregulation of HAND2 is a crucial step in endometrial carcinogenesis in mice.

Klf4 is not required for proper myeloid cell differentiation.

Mice lacking Sirt1 in Sf1-expressing neurons have increased susceptibility to diet-induced obesity and insulin resistance.

1 in 5 million in UK have abnormal PrP positivity.

Mouse models can be generated using "artificial spermatids."

DMS3 protein enables Pol V transcription in vivo.

MafA phosphorylation decreases its ubiquitination.

Antiretroviral therapy increases rates of tuberculosis across a broad range of CD4 strata.

Vitamin D deficiency effects birth weight.

A deficiency of vitamin B12 decreases blood levels of homocysteine.

A deficiency of folate increases blood levels of homocysteine.

Women with a lower birth weight are more likely to develop breast cancer later in life.

40mg/day dosage of folic acid and 2mg/day dosage of vitamin B12 does not affect chronic kidney disease (CKD) progression.

In patients with congenital heart defects, β-blockers significantly improve clinical heart failure outcomes.

Ten percent (10%) of kidney cancers in the UK are attributable to excess weight.

The risk of breast cancer among parous women decreases with placental weight of pregnancies.


Induced hepatic stem cells possess the potential to differentiate into cholangiocytic cells.

BiP is a general endoplasmic reticulum stress marker.

Traditional reviews are biased in their interpretations.

Whole brain radiotherapy increases the occurrence of new brain metastases.

Gastric lavage is an effective treatment for acute paraquat poisoning.

Early patent ductus ateriosus (PDA) screening decreases in-hospital mortality.

Roughly 55% of women with chronic pelvic pain have no underlying pathology.

Intake of folic acid (FA) and vitamin B6 (VB6) increases levels of homocysteine.

The removal of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells.

The most prevalent adverse events to Semaglutide are cardiovascular.

Sweet taste receptors on the tongue are deactivated by between 1 and 10 mM glucose.

Induced hepatic stem cells possess the potential to differentiate into hepatocytic cells.

Cancer cells can stimulate the accumulation of intra-tumoural myeloid-derived suppressor cells by promoting granulocyte colony stimulating factor production.

Osteocytes have an essential role in G-CSF induced HSPC mobilization.

Differentiation of progenitor cells to myeloid cells is skewed when insulin signaling is suppressed.

Differentiation of progenitor cells to myeloid cells is skewed upon activation of insulin signaling.

The cytokine receptor which regulates chemotaxis and formation of lymph nodes is involved in production of myeloperoxidase in the left atrium.

The generation of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells.

The myocardial cell lineage originally develops from cardiac progenitors of exclusively endodermal origin.

Activated Cdk5 regulates DNA damage-induced neuronal death.


Induced hepatic stem cells possess the potential to differentiate into hepatocytic cells.

The generation of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells.

In breast cancer, the loss of myoepithelial cells slows the transition of ductal carcinoma in situ to invasive carcinoma.

Pyridostatin decreases telomere fragility in BRCA2-deficient cells.

RANK-RANKL pathway signalling has no known association with development of Aire-expressing medullary thymic epithelial cells.

Neutrophils produce IL-1β in response to large particles.

Citrullinated proteins externalized in neutrophil extracellular traps act indirectly to perpetuate the inflammatory cycle via induction of autoantibodies.

MafA ubiquitination increases the recruitment of coavtivator P/CAF by MafA.

Cancers that initially benefit from epidermal growth factor receptor targeted therapies later become refractory through several mechanisms.

Cognitive behavioral therapy is an ineffective treatment for insomnia

Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 inhibit West Nile virus replication in cortical neurons.

Hematopoietic Stem Cell purification reaches purity rates above 90%.

Specialized functional cell types can be derived from human pluripotent stem cells.

Androgenetic haploid mouse embryonic stem cells (ESCs) can be derived and genetically manipulated in vitro.


Induction of urokinase receptor signaling in podocytes causes foot process effacement and proteinuria.

Genetic deficiency of mast cells leads to decreased weight gain in a mouse model of diet-induced obesity.

ALDH1 expression is associated with poorer prognosis for breast cancer primary tumors.

4-PBA treatment raises endoplasmic reticulum stress in response to general endoplasmic reticulum stress markers.

Patients with microcytosis and higher erythrocyte count are more vulnerable to severe malarial anaemia when infected with Plasmodium falciparum.

Aged patients are more susceptible to ischaemia/reperfusion injury.

Microglia are an innate immune cell type of the central nervous system.

Pyridostatin encourages proliferation of homologous recombination - defective cells.

Activator-inhibitor pairs are provided ventrally by Xrl-sizzled.

Primary pro-inflammatory cytokines suppress secondary pro- and anti-inflammatory mediators.

The first MBT repeat of the four malignant brain tumor (4MBT) domain of Drosophila's Sfmbt and of the orthologous mammalian L3MBTL2 is required for the interaction with the spacer region of Drosophila's Pleiohomeotic (Pho) or its human ortholog YY1.

Osteoparthritis (OA) is characterized by degeneration of articular cartilage, joint edge, and subchondral bone hyperplasia.

Reduced levels of lipolysis leads to higher P38 phosphorylation in adipose tissue.

Increased lipolysis leads to higher P38 phosphorylation in adipose tissue.

Depletion of nitric oxide is responsible for vasospasm.

The morphology change from large white adipocytes to small brown adipocytes is a sign of decreased energy expenditure potential in white adipose tissue.

The effect of Lipopolysaccharides on kidney barrier function is dependent on inflammation levels.

Rhythmic expression of Cry1 translates directly into a circadian regulation of cAMP signaling in gluconeogenesis.

The morphology change from large white adipocytes to small brown adipocytes is a sign of increased energy expenditure potential in white adipose tissue.

An M2-like phenotype in brown adipose tissue macrophages is quickly induced by cold exposure.


Inhibiting HDAC6 increases survival of mice with ARID1A mutated tumors.

Autophagy deficiency in the liver increases vulnerability to insulin resistance.

Risedronate increases risk of vertebral and non-vertebral fractures.

Rotator cuff exercises are more effective than general exercise therapy in reducing pain and improving function of the shoulder.

De novo assembly of sequence data has shorter contigs than unassembled sequence data.

Decreased conversion of PGE 2 to PPARy ligand 15-ket-PGE 2 causes accumulation of PGE.

Foxk2 regulates autophagy genes in muscle cells and fibroblast cells.

Female carriers of the Apolipoprotein E4 (APOE4) allele have longer lifetime exposure to estrogen due to an increased reproductive period.

Prescribed exercise training improves quality of life.

Lack of FGF21 in mice increases life expectancy.

Reduced phosphorylation of PP2A increases HDAC4 dephosphorylation by enhancing PP2A-HDAC4 interaction.

A deficiency of vitamin B6 decreases blood levels of homocysteine.

Reduced phosphorylation of PP2A suppresses HDAC4 dephosphorylation.

B3-Galectin increases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR.

B3-Galectin decreases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR.

Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes epithelial damage.

ALDH1 expression is associated with poorer prognosis for breast cancer primary tumors.

In transgenic mice harboring green florescent protein under the control of the Sox2 promoter, more than 50 percent of the cells with green florescent colocalize with cell proliferation markers.

Mice without IFN-γ or its receptor are highly susceptible to EAM induced with α-MyHC/CFA.


Inhibiting focal adhesion formation enables cells to convert mechanical strain into eventual scarring.

Increased microtubule acetylation repairs interference of axonal transport caused by LRRK2 Roc-COR domain mutations.

A diminished ovarian reserve does not solely indicate infertility in an a priori non-infertile population.

HNF4A mutations are associated with macrosomia in infancy.

Addition of BMP4, activin A, CHIR99021, and SU504 to reprogramming fibroblasts generates, expands and maintains cardiovascular progenitor cells (CPCs)

Lack of FGF21 in mice slows the rate of atherosclerotic plaque formation.

RANK-RANKL pathway signalling is linked to development of Aire-expressing medullary thymic epithelial cells.

Mice that lack Interferon-γ or its receptor are highly susceptible to experimental autoimmune myocarditis.

Increased LDL receptors plays a role in the reduction of plasma Lp(a).

Inhibiting focal adhesion formation increases the rate at which cells convert mechanical strain into inflammation and fibrosis.

Myelin sheaths play a role in action potential propagation.

The microtubule-dependent delivery and secretion of matrix metalloproteases (MMPs) is partially responsible for the disassembly of adhesion sites.

Tuberculosis-induced granulomas express different immune system protein signatures than the surrounding tissue.

The tissue surrounding the granuloma in an immune cell induces an anti-inflammatory immune response.

Flexible molecules experience less steric hindrance in the tumor microenviroment than rigid molecules.

Glioblastoma multiforme (GBM) is characterized by extensive invasion, rapid growth, necrosis, and angiogenesis.

Lamins have no effect on nuclear membrane structure maintenance.

Cancer-associated fibroblasts (CAFs) interact with cancer cells to mediate formation and activation of CAFs.


Inhibiting focal adhesion formation increases the rate at which cells convert mechanical strain into inflammation and fibrosis.

A deficiency of vitamin B6 decreases blood levels of homocysteine.

Mitochondria play a major role in apoptosis.

Intramembrane cleavage by signal peptide peptidase aids in the degradation of proteins with a complex membrane orientation.

Pure neural progenitor cell (NPC) populations can only be obtained from cell cultures that undergo passaging, filtration, or other isolation and cell sorting methods.

Carriers of HNF4A mutations are at reduced risk for diabetes.

Continued HHV-8 transmission among MSM in San Francisco may be explained by urogenital contact.

Gpr124 increases BBB breakdown in mouse models of ischemic stroke.

Removal of H3K9me3 improves reprogramming efficiency in human somatic cell nuclear transfer experiments.

H4 G94P proteins suppress degradation of free histones via Rad53-dependent mechanisms.

Oxidative DNA damage activates STING signalling.

Cancer-associated fibroblasts (CAFs) have no known interaction with cancer cells in the formation and activation of CAFs.

Increased vessel density along with a reduction in fibrosis improves the efficacy of chemotherapy treatments.

Citrullinated proteins externalized in neutrophil extracellular traps act indirectly to disrupt the inflammatory cycle.


Inhibiting glucose-6-phospate dehydrogenase improves lipogenesis by deactivating LKB1-AMPK signaling.

HOXB4 facilitates HSC expansion when co-cultured with HSCs.

N348I mutations cause resistance to nevirapine.

The density of cytokine receptor bearing cells has no effect on the distance over which cytokines act.

Mutations in RIM1 raise levels of IME1 RNA.

Charcoal shows no benefit for acute paraquat poisoning.

TNFAIP3 is a glioblastoma tumor suppressor.

Lack of FGF21 in mice increases life expectancy.

Folate and vitamin B12 levels influence the association between homocysteine and preeclampsia.

Cytochrome c is transferred from cytosol to the mitochondrial intermembrane space during apoptosis.

Increased lipolysis leads to higher P38 phosphorylation in adipose tissue.

Reduced levels of lipolysis leads to higher P38 phosphorylation in adipose tissue.

C2 works synergistically with A-769662 to activate dephosphorylated AMPK.

PCSK9 inhibitors decrease plasma Lp(a) levels.

AMP-activated protein kinase (AMPK) activation reduces inflammation-related fibrosis in the lungs.

Removal of H3K9me3 by ectopic expression of other H3K9 demethylases improves reprogramming efficiency in SCNT experiments.

Reduced phosphorylation of PP2A increases HDAC4 dephosphorylation by enhancing PP2A-HDAC4 interaction.

Removal of H3K9me3 by ectopic expression of other H3K9 demethylases decreases reprogramming efficiency in SCNT experiments.

Upregulation of PD1 causes the upregulation of Satb1.


Input from  mental and physical health care professionals is not effective at decreasing homelessness.

Pioglitazone use is not associated with an increased risk of prostate cancer.

Converting apoE4 to apoE3 by gene editing worsens the pathology associated with apoE4 in human iPSCderived neurons.

BiP is a general endoplasmic reticulum stress marker.

Differentiation of progenitor cells to myeloid cells is skewed when insulin signaling is suppressed.

Varying expression levels of EBI2 affect the positioning and migration of B cells.

Environmental factors can influence the development of breast cancer.

In S. cerevisiae, the absence of RNA surveillance pathways reduces sensitivity to high iron conditions.

Gastric lavage is an effective treatment for acute paraquat poisoning.

Self-advocacy training is effective at decreasing homelessness.

Integrated care is ineffective at tackling multiple comorbidities.

Integrated care is successful at tackling multiple comorbidities.

76-85% of people with severe mental disorder receive no treatment in low and middle income countries.

In young and middle-aged adults, current or remote uses of ADHD medications increase the risk of serious cardiovascular events.

Bariatric surgery leads to negative outcomes in mental health.

Assessing treatment adherence is more beneficial to clinical practice than measuring routine outcomes.

Bariatric surgery leads to positive outcomes in mental health.

Walking in traffic areas in London improves lung function in elderly adults.


Inside the body, falciparum parasites reproduce asexually.

Enhanced early production of inflammatory chemokines damages viral control in the lung.

Antimicrobial agents are more effective due to the pressure of antimicrobial usage.

Vaccinating the gastrointestinal tract induces protection of rectal and vaginal mucosa.

Omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegetarians.

cSMAC formation represses weak ligand signalling.

Commelina yellow mottle virus (ComYMV) has three typical badnavirus ORFs, capable of encoding proteins 23, 15, and 216 kD.

Long chain polyunsaturated fatty acids supplementation is associated with lower rates of atopic eczema at 1 year.

50% of patients exposed to radiation have activated markers of mesenchymal stem cells.

The number of unfertilized oocytes in mated hermaphrodites increases with age.

Adult tissue-resident macrophages stem from the embryonal yolk sac and fetal liver.

The innate immune response struggles to remove small numbers of parasites.

Nonhuman primates are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.

Mice are incapable of producing neutralizing antibodies in reponse to the Chikungunya virus (CHIKV) produced in mosquitos.

Eilat virus (EILV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in nonhuman primates.

Tuberculosis-induced granulomas express different immune system protein signatures than the surrounding tissue.

Anthrax spores are very difficult to dispose once they are dispersed.

Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection increases dissemination of Salmonella Typhimurium from the gut.

Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection decreases dissemination of Salmonella Typhimurium from the gut.

Microglia are an innate immune cell type of the peripheral nervous system.


Insulin decreases risk of severe kidney failure.

COPI coatmer is involved in lipid homeostasis.

BRCA 1 mutation carriers' risk of breast and ovarian cancer depends on where the mutation is located.

Dscam1 acts as a hypervariable pattern-recognition receptor for the immune system.

Physical injury represses transgultaminase activity.

Vitamin D deficiency effects birth weight.

Klf4 is not required for proper myeloid cell differentiation.

Increased mobility of retrotransposons is assosciated with mutation and higher tumorigenesis rates.

eRNAs influence is linked to senescence, aging, and carcinogenesis.

Bariatric surgery leads to positive outcomes in mental health.

Autophagy deficiency in the liver increases vulnerability to insulin resistance.

Angiotensin converting enzyme inhibitors are associated with decreased risk for functional renal insufficiency.

40mg/day dosage of folic acid and 2mg/day dosage of vitamin B12 does not affect chronic kidney disease (CKD) progression.

Medications to treat obesity do not have side effects.

Risk of cardiovascular events can be cut by a third by using antihypertensive drug therapy among hemodialysis patients.

Sudden death can occur in patients with orthostatic hypertension without cardiac conduction abnormalities.

Ambulatory blood pressure monitoring is inaccurate at diagnosing hypertension.

Medications to treat obesity have unwanted side effects.

Diabetes remission occurs less in people treated with conventional therapy than in people treated with laparoscopic adjustable gastric banding surgery.


Insulin effects appetite via ventral tegmental neurons.

Distant CREs are less conserved among species.

Migraine with aura is associated with ischemic stroke.

Prescribed exercise training improves quality of life.

Taking 400mg of α-tocopheryl acetate in combination with vitamin C reduces the risk of prostate cancer.

Up-regulation of the p53 pathway and related molecular events speeds cancer progression.

Exercise increases cancer mortality rates among Chinese citizens.

HSCT-T dosage may not be diagnostic if the onset of symptoms occurs less than 3 hours before AMI.

Mice without IFN-γ or its receptor are highly susceptible to EAM induced with α-MyHC/CFA.

HIV trans-activator protein (TAT) effectively transports large and small molecules across cellular membranes into larger populations of neurons.

Mice defective for deoxyribonucleic acid (DNA) polymerase I (polI) fail to reveal increased sensitivity to ionizing radiation (IR).

Hypothalamic glutamate neurotransmission is unrelated to energy balance.

Energy balance requires hypothalamic glutamate neurotransmission.

Differentiation of progenitor cells to myeloid cells is skewed upon activation of insulin signaling.

Mice lacking Sirt1 in Sf1-expressing neurons have increased susceptibility to diet-induced obesity and insulin resistance.

Differentiation of progenitor cells to myeloid cells is skewed when insulin signaling is suppressed.

Foxk2 regulates autophagy genes in muscle cells and fibroblast cells.

The proliferative capacity of neural progenitors differs across species.

Mice lacking Sirt1 in Sf1-expressing neurons are immune to diet-induced obesity and insulin resistance.


Intake of folic acid (FA) and vitamin B6 (VB6) increases levels of homocysteine.

p16INK4A degradation is  linked to an abnormal wound response caused by the microinvasive step of advanced Oral Potentially Malignant Lesions (OPMLs).

HbA1c consistently overestimates glycemic control in black individuals with Sickle cell trait (SCT).

Pediatric SCD patients with vaso-occlusive crisis show increased morphine use after breathing 80 ppm iNO for 4 hours.

Nuclear transfer from adult human fibroblasts to human oocytes can give rise to blastocysts containing expandable pluripotent cells.

Ethanol stress increases the expression of SRL in bacteria.

Forkhead 0 (fox0) transcription factors are involved in cellular differentiation.

Emodin forms hydrogen bonds with residues involved in PGAM1 substrate binding.

Primary pro-inflammatory cytokines suppress secondary pro- and anti-inflammatory mediators.

Chinese individuals with TT homozygosity in the MTHFR gene are less vulnerable to strokes caused by low levels of folate intake.

Intake of folic acid (FA) and vitamin B6 (VB6) reduces levels of homocysteine.

A deficiency of folate increases blood levels of homocysteine.

A deficiency of vitamin B6 decreases blood levels of homocysteine.

A deficiency of vitamin B12 decreases blood levels of homocysteine.

Vitamin D is an important factor in the relationship between calcium and parathyroid hormone.

LDL cholesterol has a causal role in the development of cardiovascular disease.

Folate and vitamin B12 levels influence the association between homocysteine and preeclampsia.

Chinese individuals with TT homozygosity in the MTHFR gene are more vulnerable to strokes caused by low levels of folate intake.

40mg/day dosage of folic acid and 2mg/day dosage of vitamin B12 does not affect chronic kidney disease (CKD) progression.


Intake of folic acid (FA) and vitamin B6 (VB6) reduces levels of homocysteine.

In domesticated populations of Saccharomyces cerevisiae, segmental aneuploidy occurs infrequently.

ER-localized phosphatase Sac1 processes PI4P through coordination with OSBP and the endosome-localized protein sorting nexin 2.

TRAP+ osteoclasts regulate mature osteoblast maintenance.

High levels of CRP lead to a higher risk of exacerbations in chronic obstructive pulmonary disease (COPD).

Stiff substrates inhibit mesodermal differentiation by degrading beta-catenin in an integrin-dependent manner.

The most prevalent adverse events to Semaglutide are gastrointestinal.

During non-homologous end joining, the ligation step is not as tolerant of disrepairs and other distortions when joining 5' of strand breaks as compared to 3' strand breaks.

KLF4 is necessary for VSMCs to gain genetic characteristics of other cell types within atherosclerotic lesions.

B cells go though plasmablast differentiation and antibody production by continuous expression of EBI2.

Overexpressing Cnp1 N-tail variants exacerbates the temperature-sensitive growth defect of scm3-139.

Chinese individuals with TT homozygosity in the MTHFR gene are less vulnerable to strokes caused by low levels of folate intake.


Integrated care is ineffective at tackling multiple comorbidities.

Antiretroviral therapy increases rates of tuberculosis across a broad range of CD4 strata.

APOE4 expression in iPSC-derived neurons results in decreased tau phosphorylation.

Pioneer factor OCT3/4 interacts with major chromatin remodeling factors.

Lamins have no effect on nuclear membrane structure maintenance.

Perigenital skin is not the primary site of HIV acquisition.

Sildenafil worsens erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.

Helicobacter pylori-induced aberrant NF-kB-dependent expression of activation-induced cytidine deaminase contributes to the mutagenesis of host DNA.

Women are more susceptible to death due to pneumonia when compared to men.

Integrated care is successful at tackling multiple comorbidities.

Assessing treatment adherence is more beneficial to clinical practice than measuring routine outcomes.

Input from  mental and physical health care professionals is not effective at decreasing homelessness.

Measuring routine outcomes is more beneficial to clinical practice than assessing treatment adherence.

Self-advocacy training is effective at decreasing homelessness.

Cost effectiveness evaluations based on cRCT data accurately reflect prices for patients in actual clinical practice.

Cost effectiveness evaluations based on cRCT data lack external validity.

Asymptomatic visual impairment screening in elderly populations leads to improved vision.

Integrating classroom-based collaborative learning with Web-based collaborative learning offers the best class performance.