Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection decreases dissemination of Salmonella Typhimurium from the gut.

Surgical treatment is not superior to non-surgical in treating adults with displaced fractures of the proximal humerus.

Ly49Q directs the organization of neutrophil polarization by regulating membrane raft functions.

Including pharmacists in rounding teams does not alter the incidence of adverse drug events (ADEs).

BCL-2 activation antagonizes the apoptotic effects of c-Myc.

Citrullinated proteins externalized in neutrophil extracellular traps act indirectly to disrupt the inflammatory cycle.

IgA plasma cells that are specific for transglutaminase 2 are scarce in the duodenal mucosa of celiac disease patients when the disease is active.

Marmosets have a brain region homologous to Broca's area.

Mouse models can be generated using "artificial spermatids."

Gpr124 increases BBB breakdown in mouse models of ischemic stroke.

Klf4 is not required for proper myeloid cell differentiation.

Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection increases dissemination of Salmonella Typhimurium from the gut.

Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 inhibit West Nile virus replication in cortical neurons.

Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 encourage West Nile virus replication in cortical neurons.

The latent infection of myeloid cells with human cytomegalovirus induces a number of changes in gene expression.

A T helper 2 cell (Th2) environment impedes disease development in patients with systemic lupus erythematosus (SLE).

Nonhuman primates are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.

Tuberculosis-induced granulomas express different immune system protein signatures than the surrounding tissue.

The HSV-2 infection is typically asymptomatic.

Eilat virus (EILV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in nonhuman primates.


Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection increases dissemination of Salmonella Typhimurium from the gut.

Converting apoE4 to apoE3 by gene editing worsens the pathology associated with apoE4 in human iPSCderived neurons.

Klf4 is important for proper myeloid cell differentiation.

In S. cerevisiae, the absence of RNA surveillance pathways causes sensitivity to high iron conditions.

Vitamin D deficiency effects birth weight.

Localization of PIN1 in the roots of Arabidopsis requires VPS9a

The proportion of people with visual difficulty is two times higher in low-income countries than in high-income countries.

Female carriers of the Apolipoprotein E4 (APOE4) allele have shorter lifetime exposure to estrogen due to a decreased reproductive period.

Antiretroviral therapy increases rates of tuberculosis across a broad range of CD4 strata.

Increased mobility of retrotransposons does not lead to mutation and higher tumorigenesis rates.

Systemic immunosuppressive (IS) therapy increases the chance of cancer mortality in patients with inflammatory eye disease (IED)


Depletion of nitric oxide is responsible for vasospasm.

β-sheet opening occurs during pleurotolysin pore formation.

During the primary early antibody response activated B cells migrate toward the inner-and outer follicular areas where oxysterol accumulation is generated by stromal cells.

Female carriers of the Apolipoprotein E4 (APOE4) allele have longer lifetime exposure to estrogen due to an increased reproductive period.

MeCP2 influences the synaptic maturation of neurons.

Incidence of 10/66 dementia is higher than the incidence of DSM-IV dementia.

The ability of activator E2Fs in preventing cell death is limited to terminally differentiated cells.

Increase of p62 in prostate tumor stroma results in defective autophagy.

Alteration of origin firing causes changes in termination zones of Okazaki fragments.

Whole brain radiotherapy increases the occurrence of new brain metastases.

Reduced levels of lipolysis leads to higher P38 phosphorylation in adipose tissue.

Increased lipolysis leads to higher P38 phosphorylation in adipose tissue.

The effect of Lipopolysaccharides on kidney barrier function is dependent on inflammation levels.

Differentiation of progenitor cells to myeloid cells is skewed when insulin signaling is suppressed.

The cytokine receptor which regulates chemotaxis and formation of lymph nodes is involved in production of myeloperoxidase in the left atrium.

Higher plasma levels of I-carnitine, when associated with trimethylamine N-oxide, are negatively correlated with cardiovascular events in humans.

Higher plasma levels of I-carnitine, when associated with trimethylamine N-oxide, are positively correlated with cardiovascular events in humans.

Sudden death can occur in patients with orthostatic hypertension without cardiac conduction abnormalities.

Differentiation of progenitor cells to myeloid cells is skewed upon activation of insulin signaling.


Deregulation of HAND2 is a crucial step in endometrial carcinogenesis in mice.

The latent infection of myeloid cells with human cytomegalovirus induces a number of changes in gene expression.

Physical injury represses transgultaminase activity.

Most termination events in Okazaki fragments are dictated by initiation patterns.

Activator-inhibitor pairs are provided ventrally by Xrl-sizzled.

Perigenital skin is not the primary site of HIV acquisition.

Pre-mRNAs associated with spliceosomal components are more stable than unassociated splicing substrates.

Adult tissue-resident macrophages are seeded before birth.

ART has no effect on the infectiveness of HIV-positive people.

p75 NTR - associated cell death executor (NADE) interacts with the p75 NTR death domain

The appearance of brown-like or beige cells primarily occurs in visceral fat, not subcutaneous fat.

HAND2 methylation is a key step in early endometrial carcinogenesis.

NR5A2 does not play a role in development of endometrial tissues.

Many cytokines that are produced by cancer cells also contribute to carcinogenesis.

EGR2 is important to myelination of the peripheral nervous system.

Decrease of p62 in prostate tumor stroma results in defective autophagy.

PGE 2 suppresss intestinal tumor growth by altering the expression of tumor suppressing and DNA repair genes.

Increase of p62 in prostate tumor stroma results in defective autophagy.

In breast cancer, the loss of myoepithelial cells slows the transition of ductal carcinoma in situ to invasive carcinoma.

Foxk2 regulates autophagy genes in muscle cells and fibroblast cells.


Destination container port throughput(CPT) is negatively related to dengue virus (DENV-1) diffusion in air traffic shipments.

ScPif1p has reduced binding ability to G-rich ssDNA compared to non-G-rich ssDNA.

Cancers that initially benefit from epidermal growth factor receptor targeted therapies later become refractory through several mechanisms.

A diminished ovarian reserve does not solely indicate infertility in an a priori non-infertile population.

Incidence of sepsis has fallen substantially from 2009 to 2014.

Guanine nucleotide exchange factors (GEFs) mediate RhoA activation in response to tensional forces on fibronectin-binding integrins.

Microcin J25 encourages nucleoside triphosphate (NTP) binding.

Patients with common epithelial cancers  are more likely to have an emergency event as their first hospital admission if they live in resource-deprived areas.

Monoclonal antibody targeting of N-cadherin inhibits castration resistance.

Destination container port throughput(CPT) is positively related to dengue virus (DENV-1) diffusion in air traffic shipments.

Origin gross domestic product(GDP) is negatively related to dengue virus (DENV-1) diffusion in air traffic shipments.

Origin gross domestic product(GDP) is positively related to dengue virus (DENV-1) diffusion in air traffic shipments.

Urbanization is an important risk factor related to the transmission of dengue fever.

Rising temperatures caused by global warming increases risk of dengue fever transmission.

Rising temperatures caused by global warming lowers the risk of dengue fever transmission.

Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 inhibit West Nile virus replication in cortical neurons.

Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 encourage West Nile virus replication in cortical neurons.

Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection increases dissemination of Salmonella Typhimurium from the gut.


Destination container port throughput(CPT) is positively related to dengue virus (DENV-1) diffusion in air traffic shipments.

The M2-phenotype in brown adipose tissue macrophages increases brown adipose tissue thermogenic activity.

Deltex interacts with eIF3. There is no known interaction between Deltex and elF3

Taking 400mg of α-tocopheryl acetate does not prevent prostate cancer.

Normal granulomas form in the absence of TNF in Zebrafish.

Chlamydia trachomatis is most prevalent in the UK among individuals in their 50s and 60s.

Mice without IFN-γ or its receptor are highly susceptible to EAM induced with α-MyHC/CFA.

In transgenic mice harboring green florescent protein under the control of the Sox2 promoter, more than 50 percent of the cells with green florescent colocalize with cell proliferation markers.

Expression of MSX2 is induced 3 hours after the addition of BMP4, which is earlier than T and CDX2.

Ultrasound guidance significantly reduces the number of traumatic procedures when attempting needle insertion.

A country's Vaccine Alliance (GAVI) eligibility is not indictivate of accelerated adoption of the Hub vaccine.


Dexamethasone increases risk of postoperative bleeding.

1 in 5 million in UK have abnormal PrP positivity.

Decrease of p62 in prostate tumor stroma results in defective autophagy.

Cardiac tissue-resident macrophages directly contribute to electrical activity.

Carriers of HNF4A mutations are at reduced risk for diabetes.

Integrated care is ineffective at tackling multiple comorbidities.

76-85% of people with severe mental disorder receive no treatment in low and middle income countries.

p75 NTR - associated cell death executor (NADE) interacts with the p75 NTR death domain

DRD1 proteins enable Pol V transcription in vivo.

Low expression of miR7a does not repress target genes or exert a biological function in testis.

Deltex has no known interactions with eIF3f.

Side effects associated with antidepressants increases risk of stroke.

Sildenafil worsens erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.

Side effects associated with antidepressants do not represent a mortality risk to postmenopausal women.

Side effects associated with antidepressants lower risk of myocardial infarction.

Pioglitazone use is significantly associated with an increased risk of pancreatic cancer.

Pioglitazone use is significantly associated with an increased risk of prostate cancer.

Stroke patients with prior use of direct oral anticoagulants have a higher risk of in-hospital mortality than stroke patients with prior use of warfarin.

Pioglitazone use is not associated with an increased risk of prostate cancer.

The most prevalent adverse events to Semaglutide are cardiovascular.


Diabetes remission occurs less in people treated with conventional therapy than in people treated with laparoscopic adjustable gastric banding surgery.

Rapamycin increases the concentration of triacylglycerols in fruit flies.

7-day-old adult Caenorhabditis elegans exhibit approximately 5% of the learning capacity seen in 1-day old adults.

There is no known interaction between Pioneer factor OCT3/4 and major chromatin remodeling factors.

De novo assembly of sequence data has shorter contigs than unassembled sequence data.

Medications to treat obesity are highly effective.

Higher plasma levels of I-carnitine, when associated with trimethylamine N-oxide, are positively correlated with cardiovascular events in humans.

aPKCz causes tumour suppression by affecting glutamine metabolism.

Side effects associated with antidepressants increases risk of stroke.

Acute ablation of Snail in the embryonic cortex affects the proliferation and number of embryonic cortical precursors.

Diabetes remission occurs more in people treated with conventional therapy than in people treated with laparoscopic adjustable gastric banding surgery.

In young and middle-aged adults, current or remote uses of ADHD medications increase the risk of serious cardiovascular events.

Autophagy deficiency in the liver increases vulnerability to insulin resistance.

Sudden death can occur in patients with orthostatic hypertension without cardiac conduction abnormalities.

Diabetic patients with acute coronary syndrome experience decreased short-term and long-term risk for bleeding events.

Medications to treat obesity do not have side effects.

Insulin decreases risk of severe kidney failure.

Nonhypertensive people who are 55 years old have a 90% chance of developing hypertension during their lifetime.

Ambulatory blood pressure monitoring is inaccurate at diagnosing hypertension.


Diabetes remission occurs more in people treated with conventional therapy than in people treated with laparoscopic adjustable gastric banding surgery.

Ethanol stress lowers the expression of PSP in bacteria.

Risedronate increases risk of vertebral and non-vertebral fractures.

There is no increased risk of hypospadias with clomiphene.

Primary pro-inflammatory cytokines suppress secondary pro- and anti-inflammatory mediators.

Active Ly49Q prevents neutrophil polarization.

Piezo1 channels are sensors for cell migration in epithelial cells.

Environmental factors can influence the development of breast cancer.

In domesticated populations of Saccharomyces cerevisiae, segmental aneuploidy is very common.

Higher plasma levels of I-carnitine, when associated with trimethylamine N-oxide, are negatively correlated with cardiovascular events in humans.

The amount of publicly available DNA data doubles every 10 months.


Diabetic patients with acute coronary syndrome experience decreased short-term and long-term risk for bleeding events.

Ethanol stress increases the expression of IBP in bacteria.

During non-homologous end joining, the ligation step is not as tolerant of disrepairs and other distortions when joining 3' of strand breaks as compared to 5' strand breaks.

Lack of FGF21 in mice leads to reduced lifespan.

A diminished ovarian reserve is a very strong indicator of infertility, even in an a priori non-infertile population.

Scapular stabilizer exercises are more effective than general exercise therapy in reducing pain and improving function of the shoulder.

Primary cervical cancer screening with HPV detection has lower longitudinal sensitivity than conventional cytology to detect cervical intraepithelial neoplasia grade 2.

A mutation in HNF4A leads to an increased risk of developing diabetes by the age of 14 years.

Differentiation of progenitor cells to myeloid cells is skewed when insulin signaling is suppressed.

JMJD6 slows the hydroxylation of C-terminal lysine

Chemical injury represses transglutaminase 2 activity.

CRP is positively correlated with postoperative mortality following Coronary Artery Bypass Graft (CABG) surgery.

High levels of CRP lead to a higher risk of exacerbations in chronic obstructive pulmonary disease (COPD).

Sudden death can occur in patients with complex ventricular arrhythmias.

Risk of cardiovascular events can be cut by a third by using antihypertensive drug therapy among hemodialysis patients.

Decreased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm.

Side effects associated with antidepressants lower risk of myocardial infarction.

Mice that lack Interferon-γ or its receptor are highly susceptible to experimental autoimmune myocarditis.


Differentiated E2f-1, -2, -3 TKO cells in the intestine do not exhibit apoptosis.

Intake of folic acid (FA) and vitamin B6 (VB6) reduces levels of homocysteine.

Mice defective for deoxyribonucleic acid (DNA) polymerase m (polm) reveal increased sensitivity to ionizing radiation (IR).

The TRaF1/C5 rs10818488 allele polymorphism regulates the neighboring C5 gene.

A strong bias in the phage genome locations where the spacers were derived has been observed in many CRISPR subtypes that confer the immunity to phage.

90% of patients with melanoma and an objective response to PD-1 blockade will experience a progression in their melanoma.

IgA plasma cells that are specific for transglutaminase 2 are scarce in the duodenal mucosa of celiac disease patients when the disease is active.

Increased microtubule acetylation exacerbates LRRK2 Roc-COR domain mutation induced locomotor deficits.

Increased purity of cytoplasmic membranes isolated from overexpressors is indicated by stronger spots for OmpF in 2D BN-PAGE gels.

Sweet taste receptors on the tongue are deactivated by between 1 and 10 mM glucose.

Mice defective for deoxyribonucleic acid (DNA) polymerase I (polI) fail to reveal increased sensitivity to ionizing radiation (IR).

The ability of activator E2Fs in preventing cell death is limited to terminally differentiated cells.

Differentiation of progenitor cells to myeloid cells is skewed when insulin signaling is suppressed.

TNFAIP3 is a glioblastoma tumor suppressor.

Klf4 is not required for proper myeloid cell differentiation.

Differentiation of progenitor cells to myeloid cells is skewed upon activation of insulin signaling.

Klf4 is important for proper myeloid cell differentiation.

Bone marrow cells don't contribute to adult macrophage compartments.

Osteocytes have an essential role in G-CSF induced HSPC mobilization.

TNFAIP3 is a tumor enhancer in glioblastoma.


Differentiation of progenitor cells to myeloid cells is skewed upon activation of insulin signaling.

Natriuretic peptides increase susceptibility to diabetes.

Prescribed exercise training improves quality of life.

Phase information is useful for predicting donor-recipient matches in organ transplantation.

Therapeutics receiving accelerated approval encounter a lower frequency of post-marketing safety events

Human embryonic stem cells give rise to cell types from all three embryonic germ layers.

Alirocumab treatment reduces apo(a) fractional clearance rate.

Female carriers of the Apolipoprotein E4 (APOE4) allele have longer lifetime exposure to estrogen due to an increased reproductive period.

Cancer-associated fibroblasts (CAFs) have no known interaction with cancer cells in the formation and activation of CAFs.

A single nucleotide variant the gene DGKK is strongly associated with increased risk of hypospadias.

PRC1-bound plasmids sediment at a slower rate in unbound plasmids than in sucrose gradients.

Cancer cells can stimulate the accumulation of intra-tumoural myeloid-derived suppressor cells by promoting granulocyte colony stimulating factor production.

The proliferative capacity of progenitors is regulated cell-autonomously.

The myocardial cell lineage originally develops from cardiac progenitors of exclusively endodermal origin.

Autophagy deficiency in the liver increases vulnerability to insulin resistance.

Klf2 is important for proper myeloid cell function.

Cancer-associated fibroblasts (CAFs) interact with cancer cells to mediate formation and activation of CAFs.


Differentiation of progenitor cells to myeloid cells is skewed when insulin signaling is suppressed.

Systemic immunosuppressive (IS) therapy does not enhance the chance of cancer mortality in patients with inflammatory eye disease (IED)

PrimPol generates short DNA replication intermediates on the leading strand during DNA replication.

VgrG (Tssl) protein punctures membranes by forming a spike at the tip of the tube apparatus.

Normal expression of RUNX1 causes tumorsupressing effects.

Autologous transplantation of mesenchymal stem cells has better graft function than induction therapy with anti-interleukin-2 receptor antibodies.

Commelina yellow mottle virus (ComYMV) has three typical badnavirus ORFs, capable of encoding proteins 23, 15, and 216 kD.

Inhibiting focal adhesion formation enables cells to convert mechanical strain into eventual scarring.

Angiotensin converting enzyme inhibitors are associated with decreased risk for functional renal insufficiency.

Broadly HIV-1 Neutralizing Antibodies (bnAb) 10EB have no affinity for phospholipids.

A T helper 2 cell (Th2) environment impedes disease development in patients with systemic lupus erythematosus (SLE).


Diminished ovarian reserve is a reliable indicator of infertility in a non-infertile population.

Patients with common epithelial cancers are less likely to have an emergency event as their first hospital admission if they live in resource-deprived areas.

Piezo1 channels are sensors for cell migration in epithelial cells.

In chronic viral infections or tumors, peptides that selectively inhibit PTPRS can be utilized to boost insufficient activity of pDCs.

Post-transcriptional handling of mitochondrial transcripts occurs in mitochondrial RNA granules.

Propriospinal interneurons that play a role in the plastic reorganization of spinal circuits are integral for recovery from spinal cord injury.

IL-6 signaling plays a major role in atherosclerotic cardiovascular disease.

The generation of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells.

Risk-adjusted mortality rates are similar in teaching and non-teaching hospitals.

A diminished ovarian reserve is a very strong indicator of infertility, even in an a priori non-infertile population.

A diminished ovarian reserve does not solely indicate infertility in an a priori non-infertile population.

The mean suicide rate in women is lower after miscarriage than live birth.

The mean suicide rate in women is higher after miscarriage than live birth.

The number of unfertilized oocytes in mated hermaphrodites increases with age.

The risk of breast cancer among parous women decreases with placental weight of pregnancies.

Female carriers of the Apolipoprotein E4 (APOE4) allele have shorter lifetime exposure to estrogen due to a decreased reproductive period.

Female carriers of the Apolipoprotein E4 (APOE4) allele have longer lifetime exposure to estrogen due to an increased reproductive period.

53% of perinatal mortality is due to low birth weight.


Distant CREs are important for transcriptional regulation.

Misunderstandings between doctors and patients can lead to non-adherence.

Vitamin D deficiency effects birth weight.

Tumor development occurs in conjunction with suppression of pro-inflammatory cytokines.

Increased flux of microbial products suppresses immune responses.

Chlamydia trachomatis is most prevalent in the UK among individuals in their 50s and 60s.

A mutation in HNF4A leads to an increased risk of developing diabetes by the age of 14 years.

Cnn1 recruitment varies with cell cycle timing.

Autophagy deficiency in the liver increases vulnerability to insulin resistance.

Treatment with a protein named FN impairs regenerative abilities of aged muscles.

Androgenetic haploid mouse embryonic stem cells (ESCs) can be derived and genetically manipulated in vitro.

Distant CREs are less conserved among species.

Long - range chromatin interactions regulate transcription.

Cis-acting lncRNAs control the expression of genes that are positioned in the vicinity of their transcription sites.

Active caspase-11 participate in regulating phagosome-lysosome fusion.

Forkhead 0 (fox0) transcription factors are involved in cellular differentiation.

Sequence conservation in gene regulatory regions between species is a high-accuracy predictor of conserved functionality.

Binding of p53 to enhancer regions (p53BERs) regulates the activity of p53 transcription and cell cycle arrest through the production of p53-dependent eRNAs.

eRNAs influence is linked to senescence, aging, and carcinogenesis.

Concentrations of SNV and CNV in stem-cell regulatory elements and binding sites of transcription factors in iPSC-lines are distinct from their founding cells.


Distant CREs are less conserved among species.

DUSP4 downregulation deactivates the Ras-ERK pathway

Sepsis related mortality has risen from 2009 to 2014.

TRAP+ osteoclasts regulate mature osteoblast maintenance.

Activator-inhibitor pairs are provided ventrally by Xrl-sizzled.

Pro-inflammatory cytokines are up repressed during tumor development.

AZT given with ribavirin increases anemia.

Anthrax spores are very difficult to dispose once they are dispersed.

The G34R/V mutation does not create a hypomethylated phenotype at the H3K36 histone.

PRC1-bound plasmids sediment at a slower rate in unbound plasmids than in sucrose gradients.

Emodin forms hydrogen bonds with residues involved in PGAM1 substrate binding.

Sequence conservation in gene regulatory regions between species is a poor predictor of conserved functionality.

Pseudoknots are not evolutionarily conserved in most eukaryotes.

r-protein chaperones are found in complexes with their r-protein binding partners.

mcm 5 s 2 U is required for proper decoding of NNR codons in eukaryotes.

A strong bias in the phage genome locations where the spacers were derived has been observed in many CRISPR subtypes that confer the immunity to phage.

Low nucleosome occupancy correlates with high methylation levels across species.


Drosophila supracellular actomyosin structures are found at boundaries in wing imaginal discs.

B3-Galectin decreases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR.

Deregulation of HAND2 is a crucial step in endometrial carcinogenesis in mice.

Women with a lower birth weight are more likely to develop breast cancer later in life.

Tuberculosis incidence occurs at higher rates in more sparsely populated areas in the UK.

B3-Galectin increases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR.

GATA3 regulates cell cycle progression in bone marrow hematopoietic stem cells.

qSOFA scores are associated with length of stay in emergency department patients.

Having a main partner improves HIV outcomes.

Lipopolysaccharides have an inflammation independent effect on kidney barrier function.

Active caspase-11 participate in regulating phagosome-lysosome fusion.

The C-type lectin receptor (CLEC-2) rearranges the actin cytoskeleton in dendritic cells to promote efficient motility along stromal surfaces.

Lamins are found within the inner layer of the nuclear membrane of all cells.

Lamins are found within the inner layer of the mitochondrial membrane of all cells.

Activator-inhibitor pairs are provided ventrally by Xrl-sizzled.

Lamins are associated with nuclear membrane structure maintenance.

Cis-acting lncRNAs control the expression of genes that are positioned in the vicinity of their transcription sites.

Upregulation of dynein in Drosophila neurons increases the number of microtubule plus-ends growing toward the cell body of each neuron.

Myelin sheaths are lipid-rich cellular structures.

MICAL redox enzymes regulate actin dynamics in many cell types.


Dscam1 acts as a hypervariable pattern-recognition receptor for the immune system.

BiP is a general endoplasmic reticulum stress marker.

p16INK4A degradation is  linked to an abnormal wound response caused by the microinvasive step of advanced Oral Potentially Malignant Lesions (OPMLs).

Sepsis related mortality has risen from 2009 to 2014.

Bone Marrow (BM) transplantation is used to treat acute myeloid leukemia (AML)

The repeat-variable diresidue (RVD) in the loop of Transcription-Activator Like (TAL) effectors specifies the nucleotides-amino acid contact at the target promoter element.

The peak incidence of fractures occurs during pubertal growth spurt in early adolescents.

Hematopoietic Stem Cell purification reaches purity rates above 90%.

Natriuretic peptides increase susceptibility to diabetes.

Lamins are found within the inner layer of the nuclear membrane of all cells.

In melanoma, anti-CTLA-4 treatment reinvigorates exhausted PD-1+Eomes+CD8 T cells.

Microglia are an innate immune cell type of the central nervous system.

The PPR MDA5 has twenty N-terminal CARD domains.

Toll-like receptor (TLR) signaling is involved in the pathogenesis of human MDS.

Microglia are an innate immune cell type of the peripheral nervous system.

The latent infection of myeloid cells with human cytomegalovirus induces a number of changes in gene expression.

TNFAIP3 is a glioblastoma tumor suppressor.

Commelina yellow mottle virus (ComYMV) has three typical badnavirus ORFs, capable of encoding proteins 23, 15, and 216 kD.


During non-homologous end joining, the ligation step is not as tolerant of disrepairs and other distortions when joining 3' of strand breaks as compared to 5' strand breaks.

Monoclonal antibody targeting of N-cadherin encourages metastasis.

Splenomegaly is observed in knockin mouse lacking the SHP-2 MAPK pathway.

Acute ablation of Snail in the embryonic cortex affects the proliferation and number of embryonic cortical precursors.

Diabetes remission occurs less in people treated with conventional therapy than in people treated with laparoscopic adjustable gastric banding surgery.

An M2-like phenotype in brown adipose tissue macrophages is quickly induced by cold exposure.

Primary cervical cytology screening with HPV detection has higher longitudinal sensitivity to detect severe cervical intraepithelial neoplasia than conventional cytology.

Charcoal shows no benefit for acute paraquat poisoning.

Aggravated inflammation is dependent on NLRP3 inflammasome activation.

Cholesterol loading induces KLF4 expression in VSMCs, resulting in the expression of pro-inflammatory cytokines.

MafA ubiquitination increases the recruitment of coavtivator P/CAF by MafA.

During non-homologous end joining, the ligation step is not as tolerant of disrepairs and other distortions when joining 5' of strand breaks as compared to 3' strand breaks.

mcm 5 s 2 U is required for proper decoding of NNR codons in eukaryotes.

Recognition of start codons depends on the translation initiation factor IF3.

The artifactual C-terminal helix swapping in the StART domain is observed in the Ups1-Mdm35 heterodimer of the StARkin superfamily.

Pyridostatin prevents double-strand breaks accumulation.

R2D2 stops miRNA production by increasing the selectivity of Dcr2 for long dsRNA.

The H2A-H2B eviction defect is compensated for by other histone chaperone(s).

Stacking is more stable when a purine is present in the +5 position (C1698).

Overexpressing Cnp1 N-tail variants rescues the temperature-sensitive growth defect of scm3-139.


During non-homologous end joining, the ligation step is not as tolerant of disrepairs and other distortions when joining 5' of strand breaks as compared to 3' strand breaks.

Lamins are associated with nuclear membrane structure maintenance.

The HSV-2 infection is typically asymptomatic.

CD44v6 is not associated with constitutive and reprogrammed cancer stem cells driving cancer metastasis.

Tuberculosis-induced granulomas express different immune system protein signatures than the surrounding tissue.

HIV trans-activator protein (TAT) effectively transports large and small molecules across cellular membranes into larger populations of neurons.

Reduction of Rpl38 alters the composition of the Hox gene mRNAs translation in mice without lowering overall protein synthesis.

In a naive state, blocking Wingless-Int-1 secretion from mouse embryonic stem cells inhibits self-renewal of the mouse embryonic stem cells.

Antimicrobial agents are more effective due to the pressure of antimicrobial usage.

Female carriers of the Apolipoprotein E4 (APOE4) allele have increased risk for Alzheimer's disease.

Monoclonal antibody targeting of N-cadherin inhibits growth.


During the primary early antibody response activated B cells migrate toward the inner-and outer follicular areas where oxysterol accumulation is generated by stromal cells.

Retinoic acid receptor-related orphan receptor gamma (RORγ) is a therapeutic target for castration-resistant prostate cancer (CRPC)

Deregulation of HAND2 is a crucial step in endometrial carcinogenesis in mice.

Upregulation of dynein in Drosophila neurons increases the number of microtubule plus-ends growing toward the cell body of each neuron.

The innate immune response struggles to remove small numbers of parasites.

Cellular clocks are not predictive of mitosis timing in NIH 3T3 cells.

A deficiency of vitamin B6 decreases blood levels of homocysteine.

Medications to treat obesity are highly effective.

Progerin induces premature aging in stem cells.

Sepsis related mortality has risen from 2009 to 2014.

Activator-inhibitor pairs are provided ventrally by Xrl-sizzled.

B cells go though plasmablast differentiation and antibody production by continuous expression of EBI2.

Citrullinated proteins externalized in neutrophil extracellular traps act indirectly to perpetuate the inflammatory cycle via induction of autoantibodies.

Varying expression levels of EBI2 affect the positioning and migration of B cells.

Egr3 regulates the homeostasis of B and T cells.

T cell receptor /CD3 microdomains are required to induce the immunologic synapse.

The tip of the inner tube of the toxic type VI secretion system (T6SS) antibacterial effector in Escherichia coli (E. coli) is decorated with VgrG and PAAR proteins.

Oxidative DNA damage activates STING signalling.

Citrullinated proteins externalized in neutrophil extracellular traps act indirectly to disrupt the inflammatory cycle.

Major antigen-induced signals from the T cell receptor and secondary signals from costimulatory receptors are required for T cell activation.


EG7 tumors can be killed by systemic oxaliplatin primed CD8+ T cells from the tumor-draining lymph node cells.

Active Ly49Q prevents neutrophil polarization.

Emodin forms hydrogen bonds with residues involved in PGAM1 substrate binding.

HOXB4 is a highly expressed component of cellular secretome from fetal liver cell populations.

One in five surgical randomized controlled trials are discontinued early.

The proliferative capacity of neural progenitors differs across species.

Foxp3 represses the expression of transcriptional regulators implicated in memory T cell development.

Occipital activation levels are associated with auditory spatial performance in parietal regions of the brain.

During non-homologous end joining, the ligation step is not as tolerant of disrepairs and other distortions when joining 3' of strand breaks as compared to 5' strand breaks.

MICAL redox enzymes regulate actin dynamics.

The effect of Lipopolysaccharides on kidney barrier function is dependent on inflammation levels.

CD28 signals regulate trafficking of murine auto-reactive T cells into target tissues.

IL-10 production by monocytes inhibits CD4 + T cell response.

In melanoma, anti-CTLA-4 treatment reinvigorates exhausted PD-1+Eomes+CD8 T cells.

CD28 initiates tonic signaling in conventional T cells, which causes an exhaustion phenotype and limited efficiency.

Cancer cells can stimulate the accumulation of intra-tumoural myeloid-derived suppressor cells by promoting granulocyte colony stimulating factor production.

A T helper 2 cell (Th2) environment impedes disease development in patients with systemic lupus erythematosus (SLE).

Approximately 250,000 people are infected with human T-cell lymphotropic virus type 1 in the United Kingdom.

Lice attenuated SIV vaccines induce a stronger antigen-specific T cell response in lymph node cells.


EGR2 is important to myelination of the peripheral nervous system.

Toll-like receptor (TLR) signaling is involved in the pathogenesis of human MDS.

Microglia are an innate immune cell type of the central nervous system.

Early patent ductus ateriosus (PDA) screening decreases in-hospital mortality.

Lamins are found within the inner layer of the mitochondrial membrane of all cells.

Genomic sequences involved in alternative splicing responsible for Hutchinson-Gilford progeria syndrome (HGPS) are abundant in the ''progerinonly'' allele of Lmna knock-in models.

Alirocumab treatment reduces apo(a) fractional clearance rate.

Pioglitazone use is significantly associated with an increased risk of prostate cancer.

Removal of H3K9me3 improves reprogramming efficiency in human somatic cell nuclear transfer experiments.

TNFAIP3 is a glioblastoma tumor enhancer.

Integrating classroom-based collaborative learning with Web-based collaborative learning offers the best class performance.

Egr2 regulates the homeostasis of B and T cells.

Egr3 regulates the homeostasis of B and T cells.

MeCP2 influences the synaptic maturation of neurons.

NR5A2 does not play a role in development of endometrial tissues.

Varying expression levels of EBI2 affect the positioning and migration of B cells.

Myelin sheaths play a role in action potential propagation.

NR5A2 is important in reverse cholesterol transport in humans.

Mice lacking Sirt1 in Sf1-expressing neurons are immune to diet-induced obesity and insulin resistance.


ER-localized phosphatase Sac1 processes PI4P through coordination with OSBP and the endosome-localized protein sorting nexin 2.

Bariatric surgery increases rates of postmenopausal breast cancer.

Incidence of heart failure increased by 10% in women since 1979.

Physical activity level has no association with the difference in maximal oxygen consumption between black and white youth.

Birth-weight is negatively associated with breast cancer.

MICAL redox enzymes regulate actin dynamics in many cell types.

Over half of the gabonese children with Schimmelpenning-Feuerstein-Mims syndrome (SFM) had a plasma lactate of more than 5mmol/L.

Destination container port throughput(CPT) is negatively related to dengue virus (DENV-1) diffusion in air traffic shipments.

Foxk2 regulates autophagy genes in muscle cells and fibroblast cells.

RANK-RANKL pathway signalling has no known association with development of Aire-expressing medullary thymic epithelial cells.

Active caspase-11 participate in regulating phagosome-lysosome fusion.

The NF-κB essential modulator gene induces intestinal inflammation by promoting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death.

Converting apoE4 to apoE3 by gene editing prevents the pathology associated with apoE4 in human iPSCderived neurons.

The NF-κB essential modulator gene prevents intestinal inflammation by inhibiting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death.

APOE4 expression in iPSC-derived neurons results in decreased tau phosphorylation.

Intramembrane cleavage by signal peptide peptidase aids in the degradation of proteins with a complex membrane orientation.

Binding of p53 to enhancer regions (p53BERs) regulates the activity of p53 transcription and cell cycle arrest through the production of p53-dependent eRNAs.

Converting apoE4 to apoE3 by gene editing worsens the pathology associated with apoE4 in human iPSCderived neurons.

Ly49Q directs the organization of neutrophil polarization by regulating membrane raft functions.


ERAP1 SNPs are epistatic to HLA alleles for ankylosing spondylitis.

DMS3 protein enables Pol V transcription in vivo.

Pyridostatin stabilizes the G - quadruplex in the telomeric region.

Increased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm.

The amount of publicly available DNA data doubles every 10 months.

In patients with congenital heart defects, β-blockers significantly improve clinical heart failure outcomes.

Diabetes remission occurs more in people treated with conventional therapy than in people treated with laparoscopic adjustable gastric banding surgery.

A diminished ovarian reserve does not solely indicate infertility in an a priori non-infertile population.

Converting apoE4 to apoE3 by gene editing worsens the pathology associated with apoE4 in human iPSCderived neurons.

Intra-cerebroventricular infusion of amyloid-β oligomers increases expression of fibronectin type-III domain-containing protein 5 mRNA in mice hippocampi.

Localization of PIN1 in the roots of Arabidopsis requires VPS9a

KRT17 modulates the expression of the transcriptional regulator AIRE in diseased epithelia.

N348I mutations cause resistance to nevirapine.

HNF4A mutations are associated with macrosomia in infancy.

N348I mutations reduce resistance to nevirapine.

A high microerythrocyte count protects against severe anemia in homozygous alpha (+)- thalassemia trait subjects.

Carriers of HNF4A mutations are at reduced risk for diabetes.

Interleukin-18 plays an important role in the pathogenesis of atherosclerosis.

Pseudogene PTENP1 encodes a transcript that regulates PTEN expression.


Early patent ductus ateriosus (PDA) screening decreases in-hospital mortality.

B3-Galectin decreases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR.

In young and middle-aged adults, current or remote uses of ADHD medications increase the risk of serious cardiovascular events.

The minor G allele of FOXO3 up-regulates IL-10.

Omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegetarians.

The NF-κB essential modulator gene induces intestinal inflammation by promoting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death.

Rapid phosphotransfer rates are correlated with histidine kinase regulator specificity.

TNFAIP3 is a glioblastoma tumor enhancer.

MafA phosphorylation decreases its ubiquitination.

Mutations in G-Beta protein GNB1 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.

Mice are incapable of producing neutralizing antibodies in reponse to the Chikungunya virus (CHIKV) produced in mosquitos.

Early patent ductus ateriosus (PDA) screening increases in-hospital mortality.

CRP is positively correlated with postoperative mortality following Coronary Artery Bypass Graft (CABG) surgery.

Including pharmacists in rounding teams reduces the incidence of adverse drug events (ADEs).

Including pharmacists in rounding teams does not alter the incidence of adverse drug events (ADEs).

Diabetic patients with acute coronary syndrome experience decreased short-term and long-term risk for bleeding events.

Decreased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm.

Ambulatory blood pressure monitoring is inaccurate at diagnosing hypertension.

One in five surgical randomized controlled trials are discontinued early.

Stroke patients with prior use of direct oral anticoagulants have a higher risk of in-hospital mortality than stroke patients with prior use of warfarin.


Early patent ductus ateriosus (PDA) screening increases in-hospital mortality.

Pyridostatin prevents double-strand breaks accumulation.

Formation of N-terminal pyroglutamate by glutamine cyclase (GC) competes with NTAQ1 for Nt-Gln substrates.

Destination container port throughput(CPT) is positively related to dengue virus (DENV-1) diffusion in air traffic shipments.

Algerian physicians constitue the largest component of sub-Saharan Africa-trained physicians in the United States.

At least 85% of patients exposed to radiation have activated markers of myofibroblasts.

The proportion of people with visual difficulty is two times higher in low-income countries than in high-income countries.

Medications to treat obesity do not have side effects.

Female carriers of the Apolipoprotein E4 (APOE4) allele have shorter lifetime exposure to estrogen due to a decreased reproductive period.

Charcoal is an effective treatment for acute paraquat poisoning.

Cost effectiveness evaluations based on cRCT data accurately reflect prices for patients in actual clinical practice.


Ectopic expression of Sall4, Nanog, Esrrb, and Lin28 generates induced pluripotent stem cells from mouse embryonic fibroblasts more efficiently than other factor combinations.

Physical activity level is associated with the difference in maximal oxygen consumption between black and white youth.

Enhanced early production of inflammatory chemokines damages viral control in the lung.

Self-advocacy training is effective at decreasing homelessness.

A diminished ovarian reserve is a very strong indicator of infertility, even in an a priori non-infertile population.

Reduction of purity of cytoplasmic membranes isolated from overexpressors is indicated by stronger spots for OmpA in 2D BN-PAGE gels.

Antidepressants reduce the severity of migraines.

There is no association between HNF4A mutations and diabetes risks.

The mean suicide rate in women is lower after miscarriage than live birth.

Genes involved in pre-mRNA splicing have a significant impact on genome stability.

Addition of BMP4, activin A, CHIR99021, and SU504 to reprogramming fibroblasts generates, expands and maintains cardiovascular progenitor cells (CPCs)

Specialized functional cell types can be derived from human pluripotent stem cells.

Low expression of miR7a does not repress target genes or exert a biological function in testis.

Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 encourage West Nile virus replication in cortical neurons.

MICAL redox enzymes regulate actin dynamics in many cell types.

Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 inhibit West Nile virus replication in cortical neurons.

Mice lacking Sirt1 in Sf1-expressing neurons are immune to diet-induced obesity and insulin resistance.

Activation of the Rac1 homolog CED-10 kills viable cells in SRGP-1 mutant Caenorhabditis elegans.

Myelin sheaths are lipid-rich cellular structures.


Egr2 regulates the homeostasis of B and T cells.

A deficiency of vitamin B6 decreases blood levels of homocysteine.

Input from  mental and physical health care professionals is not effective at decreasing homelessness.

Moderate consumption of candy and chocolate reduces the risk of cardiovascular disease (CVD).

Taking 400mg of α-tocopheryl acetate does not prevent prostate cancer.

Increased LDL receptors plays a role in the reduction of plasma Lp(a).

miR-142-5P is a known regulator of raised body temperature.

Upregulation of PD1 causes the downmodulation of Satb1.

Bacterial meningitis can be diagnosed on the basis of positive cerebrospinal fluid (CSF) cultures.

Differentiated E2f-1, -2, -3 TKO cells in the intestine do not exhibit apoptosis.

Egr3 regulates the homeostasis of B and T cells.

EGR2 is important to myelination of the peripheral nervous system.

Varying expression levels of EBI2 affect the positioning and migration of B cells.

Major antigen-induced signals from the T cell receptor and secondary signals from costimulatory receptors are required for T cell activation.

Reduced responsiveness to interleukin-2 in regulatory T cells is associated with autoimmune diseases such as Type 1 Diabetes.

B cells go though plasmablast differentiation and antibody production by continuous expression of EBI2.

CD28 signals regulate trafficking of murine auto-reactive T cells into target tissues.

IL-10 production by monocytes inhibits CD4 + T cell response.

Foxk2 regulates autophagy genes in muscle cells and fibroblast cells.


Egr3 regulates the homeostasis of B and T cells.

Osteocytes have an essential role in G-CSF induced HSPC mobilization.

The proliferative capacity of neural progenitors differs across species.

Oxidative DNA damage activates STING signalling.

During non-homologous end joining, the ligation step is not as tolerant of disrepairs and other distortions when joining 5' of strand breaks as compared to 3' strand breaks.

Pre-mRNAs associated with spliceosomal components are more stable than unassociated splicing substrates.

The gene daf-16, which encodes forkhead Box O (FOXO), is required for all phenotypes associated with reduced insulin/insulin-like growth factor (Igf) signaling.

Distant CREs are less conserved among species.

Antimicrobial agents are more effective due to the pressure of antimicrobial usage.

RUNX1 is downregulated or mutated in TLX1 T-ALL.

Bariatric surgery increases rates of colorectal cancer.

GATA3 regulates cell cycle progression in bone marrow hematopoietic stem cells.

GATA3 regulates self-renewal capacity in bone marrow hematopoietic stem cells.


Eilat virus (EILV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in nonhuman primates.

The density of cytokine receptor bearing cells has no effect on the distance over which cytokines act.

qSOFA scores are associated with length of stay in emergency department patients.

Guanine nucleotide dissociation inhibitor (Rho-GDI) interacts with the p75 NTR death domain

Glucose restriction to 0.05% reduces RLS (replicative life span) by 20-40% in S. cerevisiae.

Ly49Q directs the organization of neutrophil polarization by regulating membrane raft functions.

The latent infection of myeloid cells with human cytomegalovirus induces a number of changes in gene expression.

Weighed food records (WFR) result in high completion since they're cheap to run and impose low participant burden.

Migraine with aura is associated with ischemic stroke.

Replacement of OCT4 and SOX2 genes with GATA3 has the ability to reprogram human cells.

Nonhuman primates are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.

Mice are incapable of producing neutralizing antibodies in reponse to the Chikungunya virus (CHIKV) produced in mosquitos.

Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 inhibit West Nile virus replication in cortical neurons.

Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 encourage West Nile virus replication in cortical neurons.

Rising temperatures caused by global warming increases risk of dengue fever transmission.

In rhesus macaques, daily subcutaneous injections of emtricitabine are ineffective at protecting against rectally transmitted simian-human immunodeficiency virus.

Rising temperatures caused by global warming lowers the risk of dengue fever transmission.


Elevated cell-free mitochondrial DNA levels are associated with mortality.

Induced hepatic stem cells possess the potential to differentiate into hepatocytic cells.

The predominant localization of Linc00173 is in mononuclear macrophage nuclei.

Pyridostatin reduces proliferation of homologous recombination - defective cells.

76-85% of people with severe mental disorder receive no treatment in low and middle income countries.

70% of burn patients are admitted for hospitalization and further treatment after appearing at hospital emergency wards or outpatient clinics.

Incidence of 10/66 dementia is higher than the incidence of DSM-IV dementia.

Lamins are found within the inner layer of the mitochondrial membrane of all cells.

The origin of the CRF01_1b2k protein occurred between 1923 and 1956.

Pediatric SCD patients with vaso-occlusive crisis show increased morphine use after breathing 80 ppm iNO for 4 hours.

Inhibiting HDAC6 increases survival of mice with ARID1A mutated tumors.

Immune complex triggered cell death leads to sequestration of oxidized mitochondrial DNA.

A deficiency of vitamin B12 decreases blood levels of homocysteine.

The generation of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells.

The removal of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells.

53% of perinatal mortality is due to low birth weight.

Suboptimal nutrition is a leading cause of premature death

10% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.

A deficiency of vitamin B6 decreases blood levels of homocysteine.

A deficiency of folate increases blood levels of homocysteine.


Eliminating the last sporadic cases of malaria requires considerable funding.

Active Ly49Q induces neutrophil polarization.

Female carriers of the Apolipoprotein E4 (APOE4) allele have shorter lifetime exposure to estrogen due to a decreased reproductive period.

Acute ablation of KRAS causes severe growth impairment.

Transcription rates in S. cerevisiae range between 7 and 12 kb/min.

Environmentally-induced senescence is mimicked in disease modeling by adding specific molecules to the culture system.

Lamins have no effect on nuclear membrane structure maintenance.

Cis-acting lncRNAs control the expression of genes that are positioned in the vicinity of their transcription sites.

CD28 initiates tonic signaling in conventional T cells, which causes an exhaustion phenotype and limited efficiency.

VgrG (Tssl) protein punctures membranes by forming a spike at the tip of the tube apparatus.

Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission.

Urbanization is an important risk factor related to the transmission of dengue fever.

The World Health Organization's (WHO) data collection process is biased downward by unequal selection of larger outbreaks.

76-85% of people with severe mental disorder receive no treatment in low and middle income countries.

Antiretroviral therapy increases rates of tuberculosis across a broad range of CD4 strata.

Patients in stable partnerships progress from HIV to death at the same rate as patients not in partnerships.


Emodin forms hydrogen bonds with residues involved in PGAM1 substrate binding.

In pediatric tissue, most T cells are naive T cell emigrants from the thymus.

COPI coatmer is involved in lipid homeostasis.

Bariatric surgery reduces colorectal cancer.

The TRaF1/C5 rs10818488 allele polymorphism regulates the neighboring C5 gene.

Monoclonal antibody targeting of N-cadherin encourages castration resistance.

The HSV-2 infection is typically asymptomatic.

Genes involved in pre-mRNA splicing have a significant impact on genome stability.

Foxk2 regulates autophagy genes in muscle cells and fibroblast cells.

ATF4 is a general endoplasmic reticulum stress marker.

De novo assembly of sequence data has fewer specific contigs than unassembled sequence data.

The PPR MDA5 has twenty N-terminal CARD domains.

Localization of PIN1 in the roots of Arabidopsis requires VPS9a

Formation of N-terminal pyroglutamate by glutamine cyclase (GC) competes with NTAQ1 for Nt-Gln substrates.

The artifactual C-terminal helix swapping in the StART domain is observed in the Ups1-Mdm35 heterodimer of the StARkin superfamily.

MafA ubiquitination increases the recruitment of coavtivator P/CAF by MafA.

MafA phosphorylation enhances its ubiquitination.

The microtubule-dependent delivery and secretion of matrix metalloproteases (MMPs) is partially responsible for the disassembly of adhesion sites.

Mutations in RIM1 decrease levels of IME1 RNA.

C2 works synergistically with A-769662 to activate dephosphorylated AMPK.


Energy balance requires hypothalamic glutamate neurotransmission.

Ribosome-inactivating protein-2 (RIP-2) interacts with the p75 NTR death domain

MICAL redox enzymes regulate actin dynamics in many cell types.

Female carriers of the Apolipoprotein E4 (APOE4) allele have decreased risk for dementia.

Increased microtubule acetylation repairs interference of axonal transport caused by LRRK2 Roc-COR domain mutations.

Activator-inhibitor pairs are provided ventrally by Xrl-sizzled.

Transcription factor EB induces transcription of pro-inflammatory cytokines in macrophages infected with Staphylococcus aureus.

Inhibiting focal adhesion formation enables cells to convert mechanical strain into eventual scarring.

Removal of H3K9me3 by ectopic expression of other H3K9 demethylases improves reprogramming efficiency in SCNT experiments.

Forkhead 0 (fox0) transcription factors are involved in apoptosis.

DUSP4 downregulation deactivates the Ras-ERK pathway

Hypothalamic glutamate neurotransmission is unrelated to energy balance.

Insulin effects appetite via ventral tegmental neurons.

Rhythmic expression of Cry1 translates directly into a circadian regulation of cAMP signaling in hepatic glucose metabolism.

Increased lipolysis leads to higher P38 phosphorylation in adipose tissue.

Oxidative phosphorylation is one of the primary glycometabolic pathways in cells.

Occipital activation levels are associated with auditory spatial performance in parietal regions of the brain.

Reduced levels of lipolysis leads to higher P38 phosphorylation in adipose tissue.

Rhythmic expression of Cry1 translates directly into a circadian regulation of cAMP signaling in gluconeogenesis.


Enhanced early production of inflammatory chemokines damages viral control in the lung.

Surgical treatment is not superior to non-surgical in treating adults with displaced fractures of the proximal humerus.

Systemic lupus erythematosus is a risk factor for cardiovascular disease.

BRCA 1 mutation carriers' risk of breast and ovarian cancer depends on where the mutation is located.

Insulin decreases risk of severe kidney failure.

Monoclonal antibody targeting of N-cadherin inhibits growth.

Bacteriophagaes MS2 and Qβ are members of the Leviviridae.

F4/80+ macrophages regulate mature osteoblast maintenance.

Physical activity level has no association with the difference in maximal oxygen consumption between black and white youth.

Allogeneic mechanical circulatory support is not as effective as autologous mechanical circulatory support for treating acute myocardial infarction.

Eliminating the last sporadic cases of malaria requires considerable funding.

Upon viral challenge, influenza-specific memory CD4+ T cells greatly diminish the early production of inflammatory chemokines in the lung.

Upon viral challenge, influenza-specific memory CD4+ T cells greatly enhance the early production of inflammatory chemokines in the lung.

The deregulated and prolonged activation of monocytes improves inflammatory disease outcomes.

AMP-activated protein kinase (AMPK) activation reduces inflammation-related fibrosis in the lungs.

Systemic immunosuppressive (IS) therapy increases the chance of cancer mortality in patients with inflammatory eye disease (IED)

The latent infection of myeloid cells with human cytomegalovirus induces a number of changes in gene expression.

Primary pro-inflammatory cytokines suppress secondary pro- and anti-inflammatory mediators.

Systemic immunosuppressive (IS) therapy does not enhance the chance of cancer mortality in patients with inflammatory eye disease (IED)

Citrullinated proteins externalized in neutrophil extracellular traps act indirectly to perpetuate the inflammatory cycle via induction of autoantibodies.


Environmental factors can influence the development of breast cancer.

Microcin J25 encourages nucleoside triphosphate (NTP) binding.

Upon developing tyrosine-kinase inhibitor resistance, new mutations in epidermal growth factor receptors emerge and cause treatment failure.

Oxidative DNA damage activates STING signalling.

Microglia are an innate immune cell type of the central nervous system.

Occipital activation levels are associated with auditory spatial performance in parietal regions of the brain.

Having a main partner worsens HIV outcomes.

Increased flux of microbial products suppresses immune responses.

Aged patients are more susceptible to ischaemia/reperfusion injury.

Dscam1 acts as a hypervariable pattern-recognition receptor for the immune system.

Cell autonomous sex determination in somatic cells occurs in Galliformes.

Women with a lower birth weight are more likely to develop breast cancer later in life.

The risk of breast cancer among parous women decreases with placental weight of pregnancies.

In breast cancer, the loss of myoepithelial cells promotes the transition of ductal carcinoma in situ to invasive carcinoma.

In breast cancer, the loss of myoepithelial cells slows the transition of ductal carcinoma in situ to invasive carcinoma.

A breast cancer patient's capacity to metabolize tamoxifen influences treatment outcome.

Birth-weight is negatively associated with breast cancer.

Many cytokines that are produced by cancer cells also contribute to carcinogenesis.

Ten percent (10%) of kidney cancers in the UK are attributable to excess weight.

Cancers that initially benefit from epidermal growth factor receptor targeted therapies later become refractory through several mechanisms.


Environmentally-induced senescence is mimicked in disease modeling by adding specific molecules to the culture system.

Female carriers of the Apolipoprotein E4 (APOE4) allele have longer lifetime exposure to estrogen due to an increased reproductive period.

Increased mobility of retrotransposons is assosciated with mutation and higher tumorigenesis rates.

In the UK, drowning affects boys and girls equally.

Activation of PPM1D enhances p53 function.

Omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegetarians.

Ethanol stress increases the expression of IBP in bacteria.

Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission.

The density of cytokine receptor bearing cells affects the distance over which cytokines act.

Forkhead 0 (fox0) transcription factors are involved in apoptosis.

Stroke patients with prior use of direct oral anticoagulants have a higher risk of in-hospital mortality than stroke patients with prior use of warfarin.

The proliferative capacity of progenitors is regulated cell-autonomously.

eRNAs influence is linked to senescence, aging, and carcinogenesis.

The proliferative capacity of neural progenitors differs across species.

Progerin induces premature aging in stem cells.

Upon developing tyrosine-kinase inhibitor resistance, new mutations in epidermal growth factor receptors emerge and cause treatment failure.

Autophagy deficiency in the liver increases vulnerability to insulin resistance.

Pure neural progenitor cell (NPC) populations can only be obtained from cell cultures that undergo passaging, filtration, or other isolation and cell sorting methods.

Ethanol stress increases the expression of PSP in bacteria.


Epidemiological disease burden from noncommunicable diseases is more prevalent in high economic settings.

PrimPol generates short DNA replication intermediates on the leading strand during DNA replication.

Incidence of 10/66 dementia is lower than the incidence of DSM-IV dementia.

Side effects associated with antidepressants lower risk of myocardial infarction.

Vaccinating the gastrointestinal tract induces protection of rectal and vaginal mucosa.

Eilat virus (EILV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in nonhuman primates.

Albendazole is used to treat soil-transmitted helminths.

Genes regulated by Esrrb transcription factor are sensitive to Mbd3 function.

Cellular clocks are not predictive of mitosis timing in NIH 3T3 cells.

ITAM phosphorylation allows for the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).

Intramembrane cleavage by signal peptide peptidase aids in the degradation of proteins with a complex membrane orientation.

Rising temperatures caused by global warming increases risk of dengue fever transmission.

Rising temperatures caused by global warming lowers the risk of dengue fever transmission.

Urbanization is an important risk factor related to the transmission of dengue fever.

The innate immune response struggles to remove small numbers of parasites.

Suboptimal nutrition is a leading cause of premature death

76-85% of people with severe mental disorder receive no treatment in low and middle income countries.

Sepsis related mortality has risen from 2009 to 2014.

The World Health Organization's (WHO) data collection process is biased downward by unequal selection of larger outbreaks.


Ethanol stress increases the expression of IBP in bacteria.

Mice without IFN-γ or its receptor are highly susceptible to EAM induced with α-MyHC/CFA.

Replacement of OCT4 and SOX2 genes with GATA3 is not capable of reprogramming human cells.

A country's Vaccine Alliance (GAVI) eligibility is not indictivate of accelerated adoption of the Hub vaccine.

Hematopoietic Stem Cell purification reaches purity rates above 90%.

VgrG (Tssl) protein punctures membranes by forming a spike at the tip of the tube apparatus.

53% of perinatal mortality is due to low birth weight.

Polymeal nutrition increases cardiovascular mortality.

In domesticated populations of Saccharomyces cerevisiae, segmental aneuploidy occurs infrequently.

Primary cervical cytology screening with HPV detection has higher longitudinal sensitivity to detect severe cervical intraepithelial neoplasia than conventional cytology.

Deletion of ATM and Rad3 related protein is not predictive of acute tissue loss.

Ethanol stress lowers the expression of PSP in bacteria.

Ethanol stress increases the expression of SRL in bacteria.

Ethanol stress reduces the expression of SRL in bacteria.

The Snf1 complex regulates carbon and energy metabolism in baker's yeast (Saccharomyces cerevisiae).

The generation of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells.

Oxidative phosphorylation is one of the primary glycometabolic pathways in cells.

The removal of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells.


Ethanol stress increases the expression of PSP in bacteria.

p75 NTR - associated cell death executor (NADE) interacts with the p75 NTR death domain

Long chain polyunsaturated fatty acids supplementation is associated with lower rates of atopic eczema at 1 year.

Inhibiting HDAC6 increases survival of mice with ARID1A mutated tumors.

Gastric lavage is an effective treatment for acute paraquat poisoning.

Foxp3 enables the expression of transcriptional regulators implicated in memory T cell development.

Klf4 is not required for proper myeloid cell differentiation.

Female carriers of the Apolipoprotein E4 (APOE4) allele have longer lifetime exposure to estrogen due to an increased reproductive period.

Increase of p62 in prostate tumor stroma results in defective autophagy.

Pediatric SCD patients with vaso-occlusive crisis show increased morphine use after breathing 80 ppm iNO for 4 hours.

Pyridostatin deregulates G2/M progression.

AMP-activated protein kinase (AMPK) activation reduces inflammation-related fibrosis in the lungs.

Autophagy deficiency in the liver increases vulnerability to insulin resistance.

Rhythmic expression of Cry1 translates directly into a circadian regulation of cAMP signaling in hepatic glucose metabolism.


Ethanol stress increases the expression of SRL in bacteria.

LSD1-positive promoters are associated with RNA polymerase II

Students who perform poorly in the early years of medical school are less likely to commit professional misconduct later in their careers.

The ability of activator E2Fs in preventing cell death is limited to terminally differentiated cells.

Upregulation of dynein in Drosophila neurons increases the number of microtubule plus-ends growing toward the cell body of each neuron.

Increased lipolysis leads to higher P38 phosphorylation in adipose tissue.

Mice defective for deoxyribonucleic acid (DNA) polymerase m (polm) reveal increased sensitivity to ionizing radiation (IR).

The PDPN gene deactivates the C-type lectin receptor (CLEC-2).

Immune complex triggered cell death leads to sequestration of oxidized mitochondrial DNA.

Long chain polyunsaturated fatty acids supplementation is associated with lower rates of atopic eczema at 1 year.

The M2-phenotype in brown adipose tissue macrophages increases brown adipose tissue thermogenic activity.

Glucose restriction to 0.05% reduces RLS (replicative life span) by 20-40% in S. cerevisiae.

An M2-like phenotype in brown adipose tissue macrophages is quickly induced by cold exposure.


Ethanol stress lowers the expression of PSP in bacteria.

miR-142-5P is a known regulator of raised body temperature.

LDL cholesterol has a causal role in the development of cardiovascular disease.

Microcin J25 inhibits nucleoside triphosphate (NTP) binding.

Ca2+ cycling is a UCP1-dependent thermogenic mechanism.

Pure neural progenitor cell (NPC) populations can only be obtained from cell cultures that undergo passaging, filtration, or other isolation and cell sorting methods.

The DESMOND program demonstrates no significant impact on biochemical outcomes.

Healthy volunteers exhibit rapid and transient increase of cellular ATP after being bolus-injected with fructose.

Active caspase-11 participate in regulating phagosome-lysosome fusion.

Patients in stable partnerships progress from HIV to death at the same rate as patients not in partnerships.


Ethanol stress reduces the expression of SRL in bacteria.

Transcription factor EB induces transcription of pro-inflammatory cytokines in macrophages infected with Staphylococcus aureus.

Ambulatory blood pressure monitoring is inaccurate at diagnosing hypertension.

Risedronate increases risk of vertebral and non-vertebral fractures.

Decrease of p62 in prostate tumor stroma results in defective autophagy.

Moderate consumption of candy and chocolate reduces the risk of cardiovascular disease (CVD).

Bacterial meningitis can be diagnosed on the basis of positive cerebrospinal fluid (CSF) cultures.

Surfactin producing cells and exopolymer producing cells cooperate to generate "Van Gogh" bundles that have sliding abilities on specialized media.

Diabetic patients with acute coronary syndrome experience decreased short-term and long-term risk for bleeding events.

Glycan adaptation is rarely observed in the B-cell repertoire.

Improvements in OER catalysts show stable activity over several hundred hours.


Excess gestational weight gain is associated with obesity-related pregnancy outcomes.

Guanine nucleotide exchange factors (GEFs) mediate RhoA activation in response to tensional forces on fibronectin-binding integrins.

G-CSF increases the expansion and infiltration of MDSCs into tumors.

1 in 5 million in UK have abnormal PrP positivity.

Up-regulation of the p53 pathway and related molecular events speeds cancer progression.

Microcin J25 encourages nucleoside triphosphate (NTP) binding.

Increased conversion of PGE 2 to PPARy ligand 15-ket-PGE 2 causes accumulation of PGE.

Headaches are correlated with cognitive impairment.

The mean suicide rate in women is higher after miscarriage than live birth.

B3-Galectin increases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR.

Surgical treatment is not superior to non-surgical in treating adults with displaced fractures of the proximal humerus.

Birth-weight is negatively associated with breast cancer.

Women with a lower birth weight are more likely to develop breast cancer later in life.

The risk of breast cancer among parous women decreases with placental weight of pregnancies.

Medications to treat obesity do not have side effects.

53% of perinatal mortality is due to low birth weight.

Medications to treat obesity have unwanted side effects.

Female carriers of the Apolipoprotein E4 (APOE4) allele have shorter lifetime exposure to estrogen due to a decreased reproductive period.

Female carriers of the Apolipoprotein E4 (APOE4) allele have longer lifetime exposure to estrogen due to an increased reproductive period.

Vitamin D deficiency effects birth weight.


Exercise increases cancer mortality rates among Chinese citizens.

53% of perinatal mortality is due to low birth weight.

Lamins are associated with nuclear membrane structure maintenance.

CDK6 shows impaired binding to loss-of-function variants of p18 INK4C.

Upon viral challenge, influenza-specific memory CD4+ T cells greatly diminish the early production of inflammatory chemokines in the lung.

Approximately 250,000 people are infected with human T-cell lymphotropic virus type 1 in the United Kingdom.

A diminished ovarian reserve is a very strong indicator of infertility, even in an a priori non-infertile population.

The minor G allele of FOXO3 is related to less severe symptoms of Crohn's Disease.

Transplanted human glial progenitor cells can mature in their host animal.

Varenicline monotherapy is more effective after 26 weeks of treatment compared to combination nicotine replacement therapies with varenicline or bupropion.

Exercise reduces cancer mortality rates among Chinese citizens.

The risk of cancer rises with level of alcohol consumption.

Participants who quit smoking reduce lung cancer risk by approximately 50%.

Walking in traffic areas in London improves lung function in elderly adults.


Exercise reduces cancer mortality rates among Chinese citizens.

It is not proven that moderate consumption of candy and chocolate reduces the risk of cardiovascular disease (CVD) specifically.

Systemic lupus erythematosus is a risk factor for cardiovascular disease.

Induced hepatic stem cells possess the potential to differentiate into hepatocytic cells.

AMP-activated protein kinase (AMPK) activation reduces inflammation-related fibrosis in the lungs.

Mice lacking Sirt1 in Sf1-expressing neurons have increased susceptibility to diet-induced obesity and insulin resistance.

Low nucleosome occupancy correlates with high methylation levels across species.

M. stadtmanae induces ASC speck formation in BlaER1 monocytes.

Formation of N-terminal pyroglutamate by glutamine cyclase (GC) competes with NTAQ1 for Nt-Gln substrates.


Exhaustion of B cells contributes to poor Ab response in HIV-infected individuals.

Sepsis related mortality has risen from 2009 to 2014.

Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection increases dissemination of Salmonella Typhimurium from the gut.

Integrated care is ineffective at tackling multiple comorbidities.

PrimPol degrades short DNA replication intermediates on the leading strand during DNA replication.

50% of patients exposed to radiation have activated markers of mesenchymal stem cells.

Cis-acting lncRNAs control the expression of genes that are positioned in the vicinity of their transcription sites.

Human embryonic stem cells give rise to cell types from all three embryonic germ layers.

There is a positive correlation between hip fractures and statin use.

VgrG (Tssl) protein punctures membranes by forming a spike at the tip of the tube apparatus.

In domesticated populations of Saccharomyces cerevisiae, segmental aneuploidy occurs infrequently.

Chronic HIV stimulation of B cells leads to the premature exhaustion of B cells.

Antiretroviral therapy increases rates of tuberculosis across a broad range of CD4 strata.

Taking anti-depresents is associated with a decrease in the Aβ level in the brain of experimental animals.

Having a main partner worsens HIV outcomes.

Patients in stable partnerships progress from HIV to death at the same rate as patients not in partnerships.

Patients in stable partnerships have a slower progression from HIV to AIDS.

Tuberculosis-induced granulomas express different immune system protein signatures than the surrounding tissue.

A low percentage of hematopoietic progenitor cells are susceptible to HIV-1 infection ex vivo.

ART substantially reduces infectiveness of HIV-positive people.


Exposure to fine particulate air pollution is unrelated to anxiety prevalence.

Acute ablation of KRAS causes severe growth impairment.

Foxp3 enables the expression of transcriptional regulators implicated in memory T cell development.

Roughly 55% of women with chronic pelvic pain have no underlying pathology.

Guanine nucleotide exchange factors (GEFs) mediate RhoA activation in response to tensional forces on fibronectin-binding integrins.

Individuals with Alzheimers who participate in six months of physical activity improve cognitive function for up to 18 months.

Vaccinating the gastrointestinal tract induces protection of rectal and vaginal mucosa.

Marmosets have a brain region homologous to Broca's area.

Having a main partner worsens HIV outcomes.

Origin gross domestic product(GDP) is positively related to dengue virus (DENV-1) diffusion in air traffic shipments.

Ultrasound guidance significantly reduces the number of traumatic procedures when attempting needle insertion.

Headaches are correlated with cognitive impairment.

Patients with panic anxiety show decreased CSF levels of hypocretin.

High levels of CRP lead to a higher risk of exacerbations in chronic obstructive pulmonary disease (COPD).

Rising temperatures caused by global warming increases risk of dengue fever transmission.

Cognitive behavioral therapy is an ineffective treatment for insomnia

Urbanization is an important risk factor related to the transmission of dengue fever.

Rising temperatures caused by global warming lowers the risk of dengue fever transmission.

Mice without IFN-γ or its receptor are highly susceptible to EAM induced with α-MyHC/CFA.

Antidepressants increase the severity of migraines.


Expression of MSX2 is induced 3 hours after the addition of BMP4, which is earlier than T and CDX2.

Reduced levels of lipolysis leads to higher P38 phosphorylation in adipose tissue.

CHOP is a general endoplasmic reticulum stress marker.

Misunderstandings between doctors and patients can lead to non-adherence.

Consumption of whole fruits increases the risk of type 2 diabetes.

Cytosolic proteins bind to iron-responsive elements on mRNAs coding for TFRC1.

Lack of FGF21 in mice leads to atherosclerotic plaque formation.

JMJD6 catalyzes the hydroxylation of C-terminal lysine and supresses transcriptional activity.

Lack of FGF21 in mice leads to reduced lifespan.

siRNA knockdown of A20 accelerates tumor progression in an in vivo murine xenograft model.

Type 1 Diabetes is associated with subtle perturbations in T reg development.

PD-1 triggering on monocytes enhances IL-10 production by monocytes.

IL-10 production by monocytes inhibits CD4 + T cell response.

p16INK4A degradation is encoded by CDKN2A.

CD28 initiates tonic signaling in conventional T cells, which causes an exhaustion phenotype and limited efficiency.

Activation of PPM1D enhances p53 function.

Upregulation of PD1 causes the downmodulation of Satb1.

Varying expression levels of EBI2 affect the positioning and migration of B cells.

Egr2 regulates the homeostasis of B and T cells.


Expression of oncolytic virus antigens as peptides makes relapse more likely.

Prescribed exercise training improves quality of life.

Low nucleosome occupancy correlates with high methylation levels across species.

Diabetes remission occurs less in people treated with conventional therapy than in people treated with laparoscopic adjustable gastric banding surgery.

Pyridostatin induces double-strand breaks accumulation.

Mice that lack Interferon-γ or its receptor are highly susceptible to experimental autoimmune myocarditis.

Deltex interacts with eIF3. There is no known interaction between Deltex and elF3

Increased LDL receptors plays a role in the reduction of plasma Lp(a).

Activator-inhibitor pairs are provided ventrally by Xrl-sizzled.

Intra-cerebroventricular infusion of amyloid-β oligomers reduces expression of fibronectin type-III domain-containing protein 5 mRNA in mice hippocampi.

Expression of oncolytic virus antigens as peptides permits additional protection against relapse.

Persister cells provide relapse resistance in cancer patients.

Enhanced early production of inflammatory chemokines damages viral control in the lung.

90% of patients with melanoma and an objective response to PD-1 blockade will experience a progression in their melanoma.

Antiretroviral therapy increases rates of tuberculosis across a broad range of CD4 strata.

Cancer cells can stimulate the accumulation of intra-tumoural myeloid-derived suppressor cells by promoting granulocyte colony stimulating factor production.

Side effects associated with antidepressants increases risk of stroke.

Monoclonal antibody targeting of N-cadherin encourages metastasis.

In melanoma, anti-CTLA-4 treatment reinvigorates exhausted PD-1+Eomes+CD8 T cells.


Expression of oncolytic virus antigens as peptides permits additional protection against relapse.

Long chain polyunsaturated fatty acids supplementation has no significant effects on wheezing or asthma at 3 and 6 years.

4-PBA treatment raises endoplasmic reticulum stress in response to general endoplasmic reticulum stress markers.

Folate and vitamin B12 levels influence the association between homocysteine and preeclampsia.

Inside the body, falciparum parasites reproduce asexually.

Bariatric surgery reduces colorectal cancer.

Cancer-associated fibroblasts (CAFs) are constituents of tumor microenvironments

COPI coatmer is involved in lipid homeostasis.

Bariatric surgery increases rates of postmenopausal breast cancer.

The amount of publicly available DNA data doubles every 10 months.

Tuberculosis-induced granulomas express different immune system protein signatures than the surrounding tissue.

Upon viral challenge, influenza-specific memory CD4+ T cells greatly diminish the early production of inflammatory chemokines in the lung.

Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection increases dissemination of Salmonella Typhimurium from the gut.

Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection decreases dissemination of Salmonella Typhimurium from the gut.


F4/80+ macrophages regulate mature osteoblast maintenance.

Chinese individuals with TT homozygosity in the MTHFR gene are more vulnerable to strokes caused by low levels of folate intake.

61% of colorectal cancer patients are diagnosed with regional or distant metastases.

Flexible molecules experience less steric hindrance in the tumor microenviroment than rigid molecules.

Pure neural progenitor cell (NPC) populations can only be obtained from cell cultures that undergo passaging, filtration, or other isolation and cell sorting methods.

Asymptomatic visual impairment screening in elderly populations leads to improved vision.

Induced hepatic stem cells possess the potential to differentiate into hepatocytic cells.

Activation of the Rac1 homolog CED-10 kills viable cells in SRGP-1 mutant Caenorhabditis elegans.

Increased mobility of retrotransposons does not lead to mutation and higher tumorigenesis rates.

Expression of oncolytic virus antigens as peptides permits additional protection against relapse.

A high microerythrocyte count protects against severe anemia in homozygous alpha (+)- thalassemia trait subjects.

Osteocytes have an essential role in G-CSF induced HSPC mobilization.

TRAP+ osteoclasts regulate mature osteoblast maintenance.

Osteoparthritis (OA) is characterized by degeneration of articular cartilage, joint edge, and subchondral bone hyperplasia.

Fibroblast Growth Factor is a ligand which signals through receptor tyrosine kinases.

Adult tissue-resident macrophages possess a self-renewing capacity.

MFGE8 regulates fat absorption by binding to av-Beta3 and av-Beta5 integrins.

Bone marrow cells don't contribute to adult macrophage compartments.

Klf4 is important for proper myeloid cell differentiation.

The cytokine receptor which regulates chemotaxis and formation of lymph nodes is involved in production of myeloperoxidase in the left atrium.


FACT and other histone chaperone(s) compensate for Histone 2A (H2A)-histone 2B (H2B) dimer eviction during the histone exchange process.

NR5A2 is important in reverse cholesterol transport in humans.

The relationship between a breast cancer patient's capacity to metabolize tamoxifen and treatment outcome is independent of the patient's genetic make-up.

ER-localized phosphatase Sac1 processes PI4P through coordination with OSBP and the endosome-localized protein sorting nexin 2.

There is no association between HNF4A mutations and diabetes risks.

The origin of the CRF01_1b2k protein occurred between 1923 and 1956.

ERAP1 SNPs are epistatic to HLA alleles for ankylosing spondylitis.

Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 inhibit West Nile virus replication in cortical neurons.

Tuberculosis incidence occurs at higher rates in more sparsely populated areas in the UK.

The ability of activator E2Fs in preventing cell death is limited to terminally differentiated cells.

Reduced levels of lipolysis leads to higher P38 phosphorylation in adipose tissue.

The H2A-H2B eviction defect is compensated for by other histone chaperone(s).

H4 G94P proteins induce chromatin assembly, which increases free histones.

Replacement of histone H2A with H2A.Z accelerates gene activation in yeasts by destabilizing +1 nucleosomes.

H4 G94P proteins induce degradation of free histones via Rad53-dependent mechanisms.

H4 G94P proteins suppress degradation of free histones via Rad53-dependent mechanisms.

The G34R/V mutation does not create a hypomethylated phenotype at the H3K36 histone.

H4 G94P proteins inhibit chromatin assembly, which decreases free histones.

The G34R/V mutation creates a hypomethylated phenotype at the H3K36 histone.

Mutations in G-Beta protein GNB1 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.


Female carriers of the Apolipoprotein E4 (APOE4) allele have decreased risk for dementia.

Converting apoE4 to apoE3 by gene editing worsens the pathology associated with apoE4 in human iPSCderived neurons.

Chlamydia trachomatis is most prevalent in the UK among individuals in their 50s and 60s.

Lice attenuated SIV vaccines induce a stronger antigen-specific T cell response in lymph node cells.

Replacement of OCT4 and SOX2 genes with GATA3 is not capable of reprogramming human cells.

Egr3 regulates the homeostasis of B and T cells.

The PRDM1 gene, when combined with the PRDM14 gene, plays an important role during primordial germ cell specification.

The C-type lectin receptor (CLEC-2) rearranges the actin cytoskeleton in dendritic cells to promote efficient motility along stromal surfaces.

Including pharmacists in rounding teams reduces the incidence of adverse drug events (ADEs).

Pyridostatin stabilizes the G - quadruplex in the telomeric region.

Forkhead 0 (fox0) transcription factors are involved in apoptosis.

Female carriers of the Apolipoprotein E4 (APOE4) allele have increased risk for Alzheimer's disease.

Female carriers of the Apolipoprotein E4 (APOE4) allele have shorter lifetime exposure to estrogen due to a decreased reproductive period.

Female carriers of the Apolipoprotein E4 (APOE4) allele have longer lifetime exposure to estrogen due to an increased reproductive period.

Women with a lower birth weight are more likely to develop breast cancer later in life.

The risk of breast cancer among parous women decreases with placental weight of pregnancies.

Carriers of HNF4A mutations are at reduced risk for diabetes.

A mutation in HNF4A leads to an increased risk of developing diabetes by the age of 14 years.

A mutation in HNF4A leads to an increased risk of diabetes by the age of 14 years.

In British Men, haplogroup I increases risk of cardiovascular disease by 50%.


Female carriers of the Apolipoprotein E4 (APOE4) allele have increased risk for Alzheimer's disease.

Charcoal is an effective treatment for acute paraquat poisoning.

Pioneer factor OCT3/4 interacts with major chromatin remodeling factors.

ALDH1 expression is associated with poorer prognosis for breast cancer primary tumors.

Microcin J25 inhibits nucleoside triphosphate (NTP) binding.

ART has no effect on the infectiveness of HIV-positive people.

Human embryonic stem cells give rise to cell types from all three embryonic germ layers.

Mice lacking Sirt1 in Sf1-expressing neurons have increased susceptibility to diet-induced obesity and insulin resistance.

The G34R/V mutation does not create a hypomethylated phenotype at the H3K36 histone.

CRP is positively correlated with postoperative mortality following Coronary Artery Bypass Graft (CABG) surgery.

Deltex has no known interactions with eIF3f.

Physical activity does not improve cognitive function in individuals with Alzheimers.

Individuals with Alzheimers who participate in six months of physical activity improve cognitive function for up to 18 months.


Female carriers of the Apolipoprotein E4 (APOE4) allele have longer lifetime exposure to estrogen due to an increased reproductive period.

Adult tissue-resident macrophages are seeded before birth.

Physical activity does not improve cognitive function in individuals with Alzheimers.

Cancer cells can stimulate the accumulation of intra-tumoural myeloid-derived suppressor cells by promoting granulocyte colony stimulating factor production.

Sudden death can occur in patients with complex ventricular arrhythmias.

Reducing H3k4me3 methylation induces mouse epiblast stem cells to naive pluripotency efficiently.

British female students are bullied more than British male students.

De novo assembly of sequence data has fewer specific contigs than unassembled sequence data.

Cell autonomous sex determination in somatic cells occurs in Galliformes.

Sweet taste receptors on the tongue are deactivated by between 1 and 10 mM glucose.

Pyridostatin prevents double-strand breaks accumulation.

The mean suicide rate in women is lower after miscarriage than live birth.

Excess gestational weight gain is associated with obesity-related pregnancy outcomes.

The mean suicide rate in women is higher after miscarriage than live birth.

Side effects associated with antidepressants do not represent a mortality risk to postmenopausal women.


Female carriers of the Apolipoprotein E4 (APOE4) allele have shorter lifetime exposure to estrogen due to a decreased reproductive period.

0-dimensional biomaterials lack inductive properties.

Venules have less significant tunica adventitia than arterioles.

There is no relation between Erythromycin use and hypertrophic pyloric stenosis.

MICAL redox enzymes regulate actin dynamics.

Traditional reviews are biased in their interpretations.

Individuals with Alzheimers who participate in six months of physical activity improve cognitive function for up to 18 months.

Active Ly49Q prevents neutrophil polarization.

The composition of myosin-II isoform switches from the A isoform to the B isoform during hematopoietic differentiation.

Misunderstandings between doctors and patients can lead to non-adherence.

Reduced phosphorylation of PP2A suppresses HDAC4 dephosphorylation.


Fibroblast Growth Factor is a ligand which signals through receptor tyrosine kinases.

Retinoic acid receptor-related orphan receptor gamma (RORγ) is a therapeutic target for castration-resistant prostate cancer (CRPC)

Exercise increases cancer mortality rates among Chinese citizens.

Myelin sheaths play a role in action potential propagation.

FoxO3a activation in neuronal death is inhibited by reactive oxygen species (ROS).

MFGE8 regulates fat absorption by binding to av-Beta3 and av-Beta5 integrins.

Microcin J25 inhibits nucleoside triphosphate (NTP) binding.

Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection decreases dissemination of Salmonella Typhimurium from the gut.

Pseudogene PTENP1 encodes a transcript that regulates PTEN expression.

Incidence of 10/66 dementia is higher than the incidence of DSM-IV dementia.

Cancer-associated fibroblasts (CAFs) interact with cancer cells to mediate formation and activation of CAFs.

Fibroblast growth factor 21 protects against atherosclerosis by modulating adiponectin and SREBP2 levels.

Cancer-associated fibroblasts (CAFs) have no known interaction with cancer cells in the formation and activation of CAFs.

Cancer-associated fibroblasts (CAFs) are constituents of tumor microenvironments

Glioblastoma multiforme (GBM) is characterized by extensive invasion, rapid growth, necrosis, and angiogenesis.

Addition of BMP4, activin A, CHIR99021, and SU504 to reprogramming fibroblasts generates, expands and maintains cardiovascular progenitor cells (CPCs)

Cancer cells can stimulate the accumulation of intra-tumoural myeloid-derived suppressor cells by promoting granulocyte colony stimulating factor production.

The C-type lectin receptor (CLEC-2) rearranges the actin cytoskeleton in dendritic cells to promote efficient motility along stromal surfaces.

Cancers that initially benefit from epidermal growth factor receptor targeted therapies later become refractory through several mechanisms.


Fibroblast growth factor 21 protects against atherosclerosis by modulating adiponectin and SREBP2 levels.

Citrullinated proteins externalized in neutrophil extracellular traps act indirectly to perpetuate the inflammatory cycle via induction of autoantibodies.

Deletion of ATM and Rad3 related protein is not predictive of acute tissue loss.

Osteocytes have an essential role in G-CSF induced HSPC mobilization.

Increase of p62 in prostate tumor stroma results in defective autophagy.

Vaccinating the gastrointestinal tract induces protection of rectal and vaginal mucosa.

Expression of oncolytic virus antigens as peptides makes relapse more likely.

L3MBTL2 binds to H2AK119Ub marked chromatin to form a PRC1 complex.

Klf4 is important for proper myeloid cell differentiation.

There is no known interaction between Pioneer factor OCT3/4 and major chromatin remodeling factors.

In the UK, drowning affects boys and girls equally.

Lack of FGF21 in mice slows the rate of atherosclerotic plaque formation.

Lack of FGF21 in mice leads to atherosclerotic plaque formation.

Lack of FGF21 in mice leads to reduced lifespan.

Binding of p53 to enhancer regions (p53BERs) regulates the activity of p53 transcription and cell cycle arrest through the production of p53-dependent eRNAs.

Lack of FGF21 in mice increases life expectancy.

Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes fibrosis.


Flexible molecules experience less steric hindrance in the tumor microenviroment than rigid molecules.

Cancer-associated fibroblasts (CAFs) interact with cancer cells to mediate formation and activation of CAFs.

EGR2 is important to myelination of the peripheral nervous system.

Allogeneic mechanical circulatory support is not as effective as autologous mechanical circulatory support for treating acute myocardial infarction.

Enhanced early production of inflammatory chemokines damages viral control in the lung.

The minor G allele of FOXO3 up-regulates IL-10.

Monoclonal antibody targeting of N-cadherin inhibits growth.

Clathrin stabilizes the spindle fiber apparatus during mitosis.

Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection decreases dissemination of Salmonella Typhimurium from the gut.

The proliferative capacity of progenitors is regulated cell-autonomously.

Patients with common epithelial cancers  are more likely to have an emergency event as their first hospital admission if they live in resource-deprived areas.

0-dimensional biomaterials lack inductive properties.

Lamins have no effect on nuclear membrane structure maintenance.

Cancer-associated fibroblasts (CAFs) have no known interaction with cancer cells in the formation and activation of CAFs.

Myelin sheaths are lipid-rich cellular structures.

The microtubule-dependent delivery and secretion of matrix metalloproteases (MMPs) is partially responsible for the disassembly of adhesion sites.

Inhibiting focal adhesion formation enables cells to convert mechanical strain into eventual scarring.

Lamins are associated with nuclear membrane structure maintenance.


Folate and vitamin B12 levels influence the association between homocysteine and preeclampsia.

Rapamycin increases the concentration of triacylglycerols in fruit flies.

Tuberculosis incidence occurs at higher rates in more sparsely populated areas in the UK.

HbA1c consistently overestimates glycemic control in black individuals with Sickle cell trait (SCT).

Patients in stable partnerships have a slower progression from HIV to AIDS.

Increased LDL receptors plays a role in the reduction of plasma Lp(a).

Upregulation of PD1 causes the upregulation of Satb1.

H4 G94P proteins induce chromatin assembly, which increases free histones.

Consumption of whole fruits increases the risk of type 2 diabetes.

Neutrophils produce IL-1β in response to large particles.

Reduction of purity of cytoplasmic membranes isolated from overexpressors is indicated by stronger spots for OmpA in 2D BN-PAGE gels.

A deficiency of folate increases blood levels of homocysteine.

A deficiency of vitamin B12 decreases blood levels of homocysteine.

Intake of folic acid (FA) and vitamin B6 (VB6) increases levels of homocysteine.

Intake of folic acid (FA) and vitamin B6 (VB6) reduces levels of homocysteine.

A deficiency of vitamin B6 decreases blood levels of homocysteine.

Vitamin D is an important factor in the relationship between calcium and parathyroid hormone.

Vitamin D deficiency effects birth weight.

LDL cholesterol has a causal role in the development of cardiovascular disease.

Mutations in G-Beta protein GNB1 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.