COPI coatmer is involved in lipid homeostasis.

The World Health Organization's (WHO) data collection process is biased downward by unequal selection of larger outbreaks.

Inhibiting glucose-6-phospate dehydrogenase improves lipogenesis by deactivating LKB1-AMPK signaling.

Albendazole is used to treat soil-transmitted helminths.

The latent infection of myeloid cells with human cytomegalovirus induces a number of changes in gene expression.

Pure neural progenitor cell (NPC) populations can only be obtained from cell cultures that undergo passaging, filtration, or other isolation and cell sorting methods.

Sequence conservation in gene regulatory regions between species is a poor predictor of conserved functionality.

Upregulation of PD1 causes the downmodulation of Satb1.

TNFAIP3 is a tumor enhancer in glioblastoma.

Pyridostatin reduces proliferation of homologous recombination - defective cells.

Sepsis related mortality has remained stable between 2009-2014.

COPI coatmer is involved in viral replication.

Myelin sheaths are lipid-rich cellular structures.

Lipopolysaccharides have an inflammation independent effect on kidney barrier function.

ER-localized phosphatase Sac1 processes PI4P through coordination with OSBP and the endosome-localized protein sorting nexin 2.

Active H. pylori urease has a polymeric structure consisting of five distinct subunits.

The C-type lectin receptor (CLEC-2) rearranges the actin cytoskeleton in dendritic cells to promote efficient motility along stromal surfaces.

MeCP2 influences the synaptic maturation of neurons.

MICAL redox enzymes regulate actin dynamics.

The RANK-RANK-Ligand (RANKL) pathway is involved in the development of Aire-expressing medullary thymic epithelial cells (mTECs).


COPI coatmer is involved in viral replication.

Increased microtubule acetylation exacerbates LRRK2 Roc-COR domain mutation induced locomotor deficits.

Pre-mRNAs associated with spliceosomal components are less stable than unassociated splicing substrates.

Prescribed exercise training improves quality of life.

p16INK4A degradation is encoded by CDKN2A.

The one-child policy has created a hospitable environment for female infants.

mcm 5 s 2 U is required for proper decoding of NNR codons in eukaryotes.

Binding of p53 to enhancer regions (p53BERs) regulates the activity of p53 transcription and cell cycle arrest through the production of p53-dependent eRNAs.

Differentiation of progenitor cells to myeloid cells is skewed when insulin signaling is suppressed.

7-day-old adult Caenorhabditis elegans exhibit approximately 5% of the learning capacity seen in 1-day old adults.

Commelina yellow mottle virus' (ComYMV) genome consists of 2140 baise pairs.

L3MBTL2 binds to H2AK119Ub marked chromatin to form a PRC1 complex.

BLM gene encodes RecQ-class DNA helicase.

Commelina yellow mottle virus (ComYMV) has three typical badnavirus ORFs, capable of encoding proteins 23, 15, and 216 kD.

Microcin J25 encourages nucleoside triphosphate (NTP) binding.

The origin of the CRF01_1b2k protein occurred between 1923 and 1956.


CRP is positively correlated with postoperative mortality following Coronary Artery Bypass Graft (CABG) surgery.

Systemic immunosuppressive (IS) therapy does not enhance the chance of cancer mortality in patients with inflammatory eye disease (IED)

The deregulated and prolonged activation of monocytes has deleterious effects in chronic infectious conditions.

Stacking is more stable when a purine is present in the +5 position (C1698).

Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes epithelial damage.

Type 1 Diabetes is associated with subtle perturbations in T reg development.

A T helper 2 cell (Th2) environment impedes disease development in patients with systemic lupus erythematosus (SLE).

The removal of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells.

siRNA knockdown of A20 accelerates tumor progression in an in vivo murine xenograft model.

Monoclonal antibody targeting of N-cadherin inhibits growth.

Vaccinating the gastrointestinal tract induces protection of rectal and vaginal mucosa.

High levels of CRP lead to a higher risk of exacerbations in chronic obstructive pulmonary disease (COPD).

Diabetic patients with acute coronary syndrome experience decreased short-term and long-term risk for bleeding events.

Decreased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm.

Increased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm.

Sudden death can occur in patients with orthostatic hypertension without cardiac conduction abnormalities.

Risk of cardiovascular events can be cut by a third by using antihypertensive drug therapy among hemodialysis patients.

32% of liver transplantation programs required patients to discontinue methadone treatment in 2001.

Systemic lupus erythematosus is a risk factor for cardiovascular disease.

Sudden death can occur in patients with complex ventricular arrhythmias.


Ca2+ cycling controls whole-body energy homeostasis in beige fat.

An M2-like phenotype in brown adipose tissue macrophages is quickly induced by cold exposure.

Normal expression of RUNX1 causes tumorsupressing effects.

RANK-RANKL pathway signalling is linked to development of Aire-expressing medullary thymic epithelial cells.

A high microerythrocyte count protects against severe anemia in homozygous alpha (+)- thalassemia trait subjects.

Deregulation of HAND2 is a crucial step in endometrial carcinogenesis in mice.

Replacement of histone H2A with H2A.Z accelerates gene activation in yeasts by destabilizing +1 nucleosomes.

Pyridostatin stabilizes the G - quadruplex in the telomeric region.

A strong bias in the phage genome locations where the spacers were derived has been observed in many CRISPR subtypes that confer the immunity to phage.

KLF4 is necessary for VSMCs to gain genetic characteristics of other cell types within atherosclerotic lesions.

Antimicrobial agents are less effective due to the pressure of antimicrobial usage.

Ca2+ cycling is a UCP1-dependent thermogenic mechanism.

Ca2+ cycling is a UCP1-independent thermogenic mechanism.

The M2-phenotype in brown adipose tissue macrophages increases brown adipose tissue thermogenic activity.

The morphology change from large white adipocytes to small brown adipocytes is a sign of increased energy expenditure potential in white adipose tissue.

The morphology change from large white adipocytes to small brown adipocytes is a sign of decreased energy expenditure potential in white adipose tissue.

The appearance of brown-like or beige cells primarily occurs in visceral fat, not subcutaneous fat.

Healthy volunteers exhibit rapid and transient increase of cellular ATP after being bolus-injected with fructose.

Mitochondria play a trivial role in calcium homeostasis.

MFGE8 regulates fat absorption by binding to av-Beta3 and av-Beta5 integrins.


Ca2+ cycling is a UCP1-dependent thermogenic mechanism.

p75 NTR - associated cell death executor (NADE) interacts with the p75 NTR death domain

KRT17 modulates the expression of the transcriptional regulator AIRE in diseased epithelia.

General exercise therapy is more effective than scapular stabilizer exercises in reducing pain and improving function of the shoulder.

BiP is a general endoplasmic reticulum stress marker.

Most termination events in Okazaki fragments are dictated by initiation patterns.

Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 inhibit West Nile virus replication in cortical neurons.

Lack of FGF21 in mice leads to atherosclerotic plaque formation.

Kir7.1 modulates channel activity by the G protein-coupled melanocortin-4 receptor (MC4R) in the paraventricular nucleus of the hypothalamus.

Healthy volunteers exhibit rapid and transient increase of cellular ATP after being bolus-injected with fructose.

Anthrax spores remain deadly until affected areas are decontaminated.

The Snf1 complex regulates carbon and energy metabolism in baker's yeast (Saccharomyces cerevisiae).

Oxidative phosphorylation is one of the primary glycometabolic pathways in cells.

Ethanol stress increases the expression of IBP in bacteria.

Osteocytes have an essential role in G-CSF induced HSPC mobilization.

MeCP2 influences the synaptic maturation of neurons.


Ca2+ cycling is a UCP1-independent thermogenic mechanism.

In rhesus macaques, daily subcutaneous injections of tenofovir protects against rectally transmitted simian-human immunodeficiency virus.

CRP is positively correlated with postoperative mortality following Coronary Artery Bypass Graft (CABG) surgery.

Pyridostatin deregulates G2/M progression.

Mitochondria play a major role in apoptosis.

β-sheet opening occurs during pleurotolysin pore formation.

Removal of H3K9me3 by ectopic expression of other H3K9 demethylases decreases reprogramming efficiency in SCNT experiments.

TRAP+ osteoclasts regulate mature osteoblast maintenance.

A 100g dose of chloroquine chemoprophylactic regimen results in retinal toxicity after 5-6 years of weekly intake.

TNFAIP3 is a glioblastoma tumor suppressor.

Repressing IL-18 has negative effects on atherosclerotic lesion composition and progression.

Activation of the Rac1 homolog CED-10 kills viable cells in SRGP-1 mutant Caenorhabditis elegans.


Cancer cells can stimulate the accumulation of intra-tumoural myeloid-derived suppressor cells by promoting granulocyte colony stimulating factor production.

Acute ablation of Snail in the embryonic cortex affects the proliferation and number of embryonic cortical precursors.

Increased flux of microbial products suppresses immune responses.

Aggravated inflammation is dependent on NLRP3 inflammasome activation.

A mutation in HNF4A leads to an increased risk of diabetes by the age of 14 years.

Deletion of ATM and Rad3 related protein is not predictive of acute tissue loss.

Surfactin producing cells and exopolymer producing cells cooperate to generate "Van Gogh" bundles that have sliding abilities on specialized media.

M. stadtmanae does not induce ASC speck formation in BlaER1 monocytes.

Female carriers of the Apolipoprotein E4 (APOE4) allele have decreased risk for dementia.

PRC1-bound plasmids sediment at a slower rate in unbound plasmids than in sucrose gradients.

Cholesterol loading induces KLF4 expression in VSMCs, resulting in the expression of pro-inflammatory cytokines.

Cancer-associated fibroblasts (CAFs) interact with cancer cells to mediate formation and activation of CAFs.

Cancer-associated fibroblasts (CAFs) have no known interaction with cancer cells in the formation and activation of CAFs.

Cancer-associated fibroblasts (CAFs) are constituents of tumor microenvironments

Differentiation of progenitor cells to myeloid cells is skewed when insulin signaling is suppressed.

Differentiation of progenitor cells to myeloid cells is skewed upon activation of insulin signaling.

Glioblastoma multiforme (GBM) is characterized by extensive invasion, rapid growth, necrosis, and angiogenesis.

The cytokine receptor which regulates chemotaxis and formation of lymph nodes is involved in production of myeloperoxidase in the left atrium.

Induced hepatic stem cells possess the potential to differentiate into cholangiocytic cells.

Many cytokines that are produced by cancer cells also contribute to carcinogenesis.


Cancer-associated fibroblasts (CAFs) are constituents of tumor microenvironments

cSMAC formation represses weak ligand signalling.

Post-transcriptional handling of mitochondrial transcripts occurs in mitochondrial RNA granules.

Human embryonic stem cells give rise to cell types from all three embryonic germ layers.

During the primary early antibody response activated B cells migrate toward the inner-and outer follicular areas where oxysterol accumulation is generated by stromal cells.

Foxp3 enables the expression of transcriptional regulators implicated in memory T cell development.

CHOP is a general endoplasmic reticulum stress marker.

Acute ablation of KRAS causes severe growth impairment.

Low nucleosome occupancy correlates with high methylation levels across species.

RTEL1 interacts with TRF2 through a C4C4 motif

ART substantially reduces infectiveness of HIV-positive people.

Microglia are an innate immune cell type of the central nervous system.

Microglia are an innate immune cell type of the peripheral nervous system.

Fibroblast Growth Factor is a ligand which signals through receptor tyrosine kinases.

Cancers that initially benefit from epidermal growth factor receptor targeted therapies later become refractory through several mechanisms.

Flexible molecules experience less steric hindrance in the tumor microenviroment than rigid molecules.


Cancer-associated fibroblasts (CAFs) have no known interaction with cancer cells in the formation and activation of CAFs.

Commelina yellow mottle virus (ComYMV) has three typical badnavirus ORFs, capable of encoding proteins 23, 15, and 216 kD.

ER-localized phosphatase Sac1 processes PI4P through coordination with OSBP and the endosome-localized protein sorting nexin 2.

Medications to treat obesity are highly effective.

Systemic immunosuppressive (IS) therapy does not enhance the chance of cancer mortality in patients with inflammatory eye disease (IED)

Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection increases dissemination of Salmonella Typhimurium from the gut.

Tonic signaling from the scFv is amplified by MyD88/CD40.

The proportion of people with visual difficulty is two times higher in low-income countries than in high-income countries.

Egr3 regulates the homeostasis of B and T cells.

Taking 400mg of α-tocopheryl acetate in combination with vitamin C reduces the risk of prostate cancer.

Chinese individuals with TT homozygosity in the MTHFR gene are less vulnerable to strokes caused by low levels of folate intake.

Cancer-associated fibroblasts (CAFs) interact with cancer cells to mediate formation and activation of CAFs.


Cancer-associated fibroblasts (CAFs) interact with cancer cells to mediate formation and activation of CAFs.

Cognitive behavioral therapy is an ineffective treatment for insomnia

AMP-activated protein kinase (AMPK) activation reduces inflammation-related fibrosis in the lungs.

Suboptimal nutrition is a leading cause of premature death

The generation of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells.

50% of patients exposed to radiation have activated markers of mesenchymal stem cells.

Addition of BMP4, activin A, CHIR99021, and SU504 to reprogramming fibroblasts generates, expands and maintains cardiovascular progenitor cells (CPCs)

GATA3 regulates cell cycle progression in bone marrow hematopoietic stem cells.

Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission.

M. stadtmanae does not induce ASC speck formation in BlaER1 monocytes.

32% of liver transplantation programs required patients to discontinue methadone treatment in 2001.

Pro-inflammatory cytokines are up regulated during tumor development.


Cancers that initially benefit from epidermal growth factor receptor targeted therapies later become refractory through several mechanisms.

The deamination of cytidine to uridine on the minus strand of viral DNA can inactivate the viral genome by inducing G-to-A mutations.

Chlamydia trachomatis is most prevalent in the UK among sexually-experienced individuals aged 16 to 24.

Rising temperatures caused by global warming increases risk of dengue fever transmission.

Long chain polyunsaturated fatty acids supplementation has no significant effects on wheezing or asthma at 3 and 6 years.

Origin gross domestic product(GDP) is negatively related to dengue virus (DENV-1) diffusion in air traffic shipments.

Mice are incapable of producing neutralizing antibodies in reponse to the Chikungunya virus (CHIKV) produced in mosquitos.

Increased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm.

Ca2+ cycling is a UCP1-dependent thermogenic mechanism.

Guanine nucleotide exchange factors (GEFs) mediate RhoA activation in response to tensional forces on fibronectin-binding integrins.

Upon developing tyrosine-kinase inhibitor resistance, new mutations in epidermal growth factor receptors emerge and cause treatment failure.

Nonsteroidal antinflammatory drugs are ineffective as cancer treatments.

MEK inhibitors are effective treatments in RAS-driven mouse models of cancer.

Environmental factors can influence the development of breast cancer.

Up-regulation of the p53 pathway and related molecular events speeds cancer progression.


Cardiac tissue-resident macrophages directly contribute to electrical activity.

Pioneer factor OCT3/4 interacts with major chromatin remodeling factors.

Pyridostatin stabilizes the G - quadruplex in the telomeric region.

Crossover hot spots are found within gene promoters in Saccharomyces cerevisiae.

HNF4A mutations are associated with macrosomia in infancy.

Weighed food records (WFR) result in poor completion since they're costly to run and impose high participant burden.

Intramembrane cleavage by signal peptide peptidase aids in the degradation of proteins with a complex membrane orientation.

Carriers of HNF4A mutations are at reduced risk for diabetes.

In melanoma, anti-CTLA-4 treatment reinvigorates exhausted PD-1+Eomes+CD8 T cells.

Notch signaling occurs between tumor cells and stromal cells.

The myocardial cell lineage originally develops from cardiac progenitors of exclusively endodermal origin.

Mitochondria play a major role in energy production.

Adult tissue-resident macrophages possess a self-renewing capacity.

Bone marrow cells don't contribute to adult macrophage compartments.

The cytokine receptor which regulates chemotaxis and formation of lymph nodes is involved in production of myeloperoxidase in the left atrium.

Nuclear transfer from adult human fibroblasts to human oocytes can give rise to blastocysts containing expandable pluripotent cells.

Mitochondria play a trivial role in calcium homeostasis.

AMP-activated protein kinase (AMPK) activation reduces inflammation-related fibrosis in the lungs.


Carriers of HNF4A mutations are at reduced risk for diabetes.

The density of cytokine receptor bearing cells affects the distance over which cytokines act.

Amitriptyline is an effective treatment for chronic tension-type headaches.

Ca2+ cycling is a UCP1-independent thermogenic mechanism.

Active Ly49Q induces neutrophil polarization.

Addition of BMP4, activin A, CHIR99021, and SU504 to reprogramming fibroblasts generates, expands and maintains cardiovascular progenitor cells (CPCs)

The relationship between a breast cancer patient's capacity to metabolize tamoxifen and treatment outcome is independent of the patient's genetic make-up.

Ribosomopathies have a high degree of cell and tissue specific pathology.

Neutrophil extracellular trap (NET) antigens may contain the targeted autoantigens PR3 and MPO.

Antimicrobial agents are more effective due to the pressure of antimicrobial usage.

β-sheet opening occurs during pleurotolysin pore formation.

HNF4A mutations are associated with macrosomia in infancy.

There is no association between HNF4A mutations and diabetes risks.

A mutation in HNF4A leads to an increased risk of developing diabetes by the age of 14 years.

A mutation in HNF4A leads to an increased risk of diabetes by the age of 14 years.

Female carriers of the Apolipoprotein E4 (APOE4) allele have decreased risk for dementia.

Female carriers of the Apolipoprotein E4 (APOE4) allele have increased risk for Alzheimer's disease.

A deficiency of vitamin B12 decreases blood levels of homocysteine.

The generation of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells.

The removal of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells.


Cell autonomous sex determination in somatic cells occurs in Galliformes.

The HSV-2 infection is typically asymptomatic.

Polymeal nutrition increases cardiovascular mortality.

The first MBT repeat of the four malignant brain tumor (4MBT) domain of Drosophila's Sfmbt and of the orthologous mammalian L3MBTL2 is required for the interaction with the spacer region of Drosophila's Pleiohomeotic (Pho) or its human ortholog YY1.

HAND2 methylation is a key step in early endometrial carcinogenesis.

Hypocretin neurones suppress panicprone state in rats.

The effect of Lipopolysaccharides on kidney barrier function is dependent on inflammation levels.

Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection decreases dissemination of Salmonella Typhimurium from the gut.

Ribosome-inactivating protein-2 (RIP-2) interacts with the p75 NTR death domain

General exercise therapy is more effective than scapular stabilizer exercises in reducing pain and improving function of the shoulder.

Genes involved in pre-mRNA splicing have a significant impact on genome stability.

The number of unfertilized oocytes in mated hermaphrodites increases with age.

The proliferative capacity of progenitors is regulated cell-autonomously.

Mitochondria play a major role in apoptosis.

Cellular differentiation of embryonic stem cells is accompanied by changes in replication timing, transcription and nuclear localization.

Human embryonic stem cells have the capacity to give rise to differentiated progeny representative of all three embryonic germ layers.

Inside the body, falciparum parasites reproduce asexually.

Cellular clocks are not predictive of mitosis timing in NIH 3T3 cells.

Human embryonic stem cells give rise to cell types from all three embryonic germ layers.

Cellular clocks are associated with mitosis timing in NIH 3T3 cells.


Cellular clocks are associated with mitosis timing in NIH 3T3 cells.

The microtubule-dependent delivery and secretion of matrix metalloproteases (MMPs) is partially responsible for the disassembly of adhesion sites.

Students who perform poorly in the early years of medical school are less likely to commit professional misconduct later in their careers.

Crossover hot spots are found within gene promoters in Saccharomyces cerevisiae.

Converting apoE4 to apoE3 by gene editing prevents the pathology associated with apoE4 in human iPSCderived neurons.

Mutations in RIM1 decrease levels of IME1 RNA.

Nigerian physicians constitue the largest component of sub-Saharan Africa-trained physicians in the United States.

Ly49Q directs the organization of neutrophil polarization by regulating membrane raft functions.

76-85% of people with severe mental disorder receive no treatment in low and middle income countries.

CRP is positively correlated with postoperative mortality following Coronary Artery Bypass Graft (CABG) surgery.

DMS3 protein enables Pol V transcription in vivo.

Mitochondria play a major role in energy production.

Mitochondria play a trivial role in calcium homeostasis.

Foxp3 enables the expression of transcriptional regulators implicated in memory T cell development.

The Snf1 complex regulates carbon and energy metabolism in baker's yeast (Saccharomyces cerevisiae).

Long - range chromatin interactions regulate transcription.

Foxp3 represses the expression of transcriptional regulators implicated in memory T cell development.


Cellular clocks are not predictive of mitosis timing in NIH 3T3 cells.

Activation of PPM1D enhances p53 function.

Activated Cdk5 phosphorylates the ATM protein in response to DNA damage.

Microglia are an innate immune cell type of the peripheral nervous system.

Glycan adaptation is rarely observed in the B-cell repertoire.

FoxO3a activation in neuronal death is inhibited by reactive oxygen species (ROS).

Adult tissue-resident macrophages are seeded before birth.

Less than 10% of patients exposed to radiation have activated markers of mesenchymal stem cells.

CHOP is a general endoplasmic reticulum stress marker.

BRCA 1 mutation carriers' risk of breast and ovarian cancer depends on where the mutation is located.

The one-child policy has created a hospitable environment for female infants.

Cyclin A2 destruction is necessary to switch from unstable to stable kt-mt attachments in mitosis.

Recognition of start codons depends on the translation initiation factor IF3.


Cellular differentiation of embryonic stem cells is accompanied by changes in replication timing, transcription and nuclear localization.

At least 85% of patients exposed to radiation have activated markers of myofibroblasts.

A deficiency of vitamin B12 decreases blood levels of homocysteine.

Diminished ovarian reserve is a reliable indicator of infertility in a non-infertile population.

eRNAs influence is linked to senescence, aging, and carcinogenesis.

ITAM phosphorylation allows for the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).

Incidence of sepsis has fallen substantially from 2009 to 2014.

L3MBTL2 binds to H2AK119Ub marked chromatin to form a PRC1 complex.

Inhibiting HDAC6 increases survival of mice with ARID1A mutated tumors.

Normal expression of RUNX1 causes tumorsupressing effects.

B cells go though plasmablast differentiation and antibody production by continuous expression of EBI2.

Human embryonic stem cells give rise to cell types from the outer embryonic germ layer, but not the other two layers.

Differentiation of progenitor cells to myeloid cells is skewed upon activation of insulin signaling.

Nuclear transfer from adult human fibroblasts to human oocytes can give rise to blastocysts containing expandable pluripotent cells.

Understanding epigenetic regulation of replication is essential for the reational design of episomally replicating vectors.

Up-regulation of the p53 pathway and related molecular events speeds cancer progression.

Genes involved in pre-mRNA splicing have a significant impact on genome stability.


Certain immunomodulator-human dialyzable leukocyte extract (hDLE) peptides are recognized by toll-like receptors (TLRs) on macrophages and dendritic cells.

Removal of H3K9me3 improves reprogramming efficiency in human somatic cell nuclear transfer experiments.

The microtubule-dependent delivery and secretion of matrix metalloproteases (MMPs) is partially responsible for the disassembly of adhesion sites.

Reduction of purity of cytoplasmic membranes isolated from overexpressors is indicated by stronger spots for OmpA in 2D BN-PAGE gels.

ATM and Rad3 related protein are critical for sensing DNA damage.

Rhythmic expression of Cry1 translates directly into a circadian regulation of cAMP signaling in gluconeogenesis.

In British Men, haplogroup I decreases risk of cardiovascular disease.

Energy balance requires hypothalamic glutamate neurotransmission.

The PPR MDA5 has twenty N-terminal CARD domains.

Natriuretic peptides protect against diabetes.

HOXB4 is a highly expressed component of cellular secretome from fetal liver cell populations.

Toll-like receptor (TLR) signaling is involved in the pathogenesis of human MDS.

Blocking the interaction between TDP-43 and respiratory complex I proteins ND3 and ND6 prevents TDP-43-induced neuronal loss.

CD28 signals regulate trafficking of murine auto-reactive T cells into target tissues.

The NF-κB essential modulator gene induces intestinal inflammation by promoting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death.

ITAM phosphorylation allows for the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).

Repressing IL-18 has negative effects on atherosclerotic lesion composition and progression.

The NF-κB essential modulator gene prevents intestinal inflammation by inhibiting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death.

Eilat virus (EILV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in nonhuman primates.

EG7 tumors can be killed by systemic oxaliplatin primed CD8+ T cells from the tumor-draining lymph node cells.


Charcoal is an effective treatment for acute paraquat poisoning.

Hypothalamic glutamate neurotransmission is unrelated to energy balance.

Mice defective for deoxyribonucleic acid (DNA) polymerase m (polm) reveal increased sensitivity to ionizing radiation (IR).

The tip of the inner tube of the toxic type VI secretion system (T6SS) antibacterial effector in Escherichia coli (E. coli) is decorated with VgrG and PAAR proteins.

PrimPol degrades short DNA replication intermediates on the leading strand during DNA replication.

A country's Vaccine Alliance (GAVI) eligibility is not indictivate of accelerated adoption of the Hub vaccine.

Ly49Q directs the organization of neutrophil polarization by regulating membrane raft functions.

Incidence of 10/66 dementia is lower than the incidence of DSM-IV dementia.

Increased flux of microbial products provokes immune responses.

ER-localized phosphatase Sac1 processes PI4P through coordination with OSBP and the endosome-localized protein sorting nexin 2.

Charcoal shows no benefit for acute paraquat poisoning.

Gastric lavage is an effective treatment for acute paraquat poisoning.

Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission.

Anthrax spores remain deadly until affected areas are decontaminated.

High levels of CRP lead to a higher risk of exacerbations in chronic obstructive pulmonary disease (COPD).

Anthrax spores are very difficult to dispose once they are dispersed.

Gastric infection with Helicobacter pylori increases risk of gastric cancer in humans.

Gastric infection with Helicobacter pylori decreases risk of gastric cancer in humans.

Higher plasma levels of I-carnitine, when associated with trimethylamine N-oxide, are negatively correlated with cardiovascular events in humans.


Charcoal shows no benefit for acute paraquat poisoning.

Bone Marrow (BM) transplantation is used to treat acute myeloid leukemia (AML)

Epidemiological disease burden from noncommunicable diseases is more prevalent in high economic settings.

Two variants of chromosome 6q21 are associated with radiation therapy-induced second malignancies in pediatric Hodgkin lymphoma patients.

High levels of CRP lead to a higher risk of exacerbations in chronic obstructive pulmonary disease (COPD).

COPI coatmer is involved in viral replication.

Microglia are an innate immune cell type of the peripheral nervous system.

Lamins are associated with nuclear membrane structure maintenance.

Over half of the gabonese children with Schimmelpenning-Feuerstein-Mims syndrome (SFM) had a plasma lactate of more than 5mmol/L.

NR5A2 is important in reverse cholesterol transport in humans.

Replacement of histone H2A with H2A.Z accelerates gene activation in yeasts by destabilizing +1 nucleosomes.

There is no increased risk of hypospadias with clomiphene.


Chemical injury represses transglutaminase 2 activity.

Mutations in G-Beta protein GNB1 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.

Including pharmacists in rounding teams does not alter the incidence of adverse drug events (ADEs).

Mouse models can be generated using "artificial spermatids."

Ambulatory blood pressure monitoring is inaccurate at diagnosing hypertension.

Marmosets have a brain region homologous to Broca's area.

Intake of folic acid (FA) and vitamin B6 (VB6) reduces levels of homocysteine.

A high microerythrocyte count protects against severe anemia in homozygous alpha (+)- thalassemia trait subjects.

Chronic HIV stimulation of B cells leads to the premature exhaustion of B cells.

BCL-2 activation antagonizes the apoptotic effects of c-Myc.

Physical injury represses transgultaminase activity.

The deamination of cytidine to uridine on the minus strand of viral DNA can inactivate the viral genome by inducing G-to-A mutations.

A deficiency of vitamin B12 decreases blood levels of homocysteine.

Ethanol stress increases the expression of IBP in bacteria.

Autophagy deficiency in the liver increases vulnerability to insulin resistance.

A deficiency of folate increases blood levels of homocysteine.

Neutrophils produce IL-1β in response to large particles.

Immune complex triggered cell death leads to sequestration of oxidized mitochondrial DNA.

Oxidative phosphorylation is one of the primary glycometabolic pathways in cells.


Chenodeoxycholic acid treatment decreases brown adipose tissue activity.

Deltex has no known interactions with eIF3f.

There is no relation between Erythromycin use and hypertrophic pyloric stenosis.

General exercise therapy is more effective than rotator cuff exercises in reducing pain and improving function of the shoulder.

BCL-2 promotes the apoptotic effects of c-Myc.

Cholesterol loading induces KLF4 expression in VSMCs, resulting in the expression of pro-inflammatory cytokines.

TNFAIP3 is a glioblastoma tumor suppressor.

APOE4 expression in iPSC-derived neurons results in decreased tau phosphorylation.

Scapular stabilizer exercises are more effective than general exercise therapy in reducing pain and improving function of the shoulder.

Adult tissue-resident macrophages stem from the embryonal yolk sac and fetal liver.

Chenodeoxycholic acid treatment increases brown adipose tissue activity.

The M2-phenotype in brown adipose tissue macrophages increases brown adipose tissue thermogenic activity.

The morphology change from large white adipocytes to small brown adipocytes is a sign of decreased energy expenditure potential in white adipose tissue.

The morphology change from large white adipocytes to small brown adipocytes is a sign of increased energy expenditure potential in white adipose tissue.

Reduced levels of lipolysis leads to higher P38 phosphorylation in adipose tissue.

Increased lipolysis leads to higher P38 phosphorylation in adipose tissue.

An M2-like phenotype in brown adipose tissue macrophages is quickly induced by cold exposure.

Ca2+ cycling controls whole-body energy homeostasis in beige fat.

PCSK9 inhibitors decrease plasma Lp(a) levels.


Chenodeoxycholic acid treatment increases brown adipose tissue activity.

The DEXI promoter region is bound by multiple transcription factors in a murine haematopoietic progenitor cell line.

ALDH1 expression is associated with poorer prognosis for breast cancer primary tumors.

Pioglitazone use is not associated with an increased risk of prostate cancer.

Understanding epigenetic regulation of replication is essential for the reational design of episomally replicating vectors.

Inhibiting focal adhesion formation enables cells to convert mechanical strain into eventual scarring.

Expression of MSX2 is induced 3 hours after the addition of BMP4, which is earlier than T and CDX2.

Differentiated E2f-1, -2, -3 TKO cells in the intestine do not exhibit apoptosis.

siRNA knockdown of A20 accelerates tumor progression in an in vivo murine xenograft model.

The density of cytokine receptor bearing cells affects the distance over which cytokines act.

Inhibiting glucose-6-phospate dehydrogenase improves lipogenesis by deactivating LKB1-AMPK signaling.


Chinese individuals with TT homozygosity in the MTHFR gene are less vulnerable to strokes caused by low levels of folate intake.

Long chain polyunsaturated fatty acids supplementation is associated with lower rates of atopic eczema at 1 year.

Lamins have no effect on nuclear membrane structure maintenance.

Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes fibrosis.

Pre-mRNAs associated with spliceosomal components are more stable than unassociated splicing substrates.

Rising temperatures caused by global warming increases risk of dengue fever transmission.

Gastric lavage is an effective treatment for acute paraquat poisoning.

Pioneer factor OCT3/4 interacts with major chromatin remodeling factors.

HNF4A mutations are associated with macrosomia in infancy.

Chinese individuals with TT homozygosity in the MTHFR gene are more vulnerable to strokes caused by low levels of folate intake.

A deficiency of folate increases blood levels of homocysteine.

Intake of folic acid (FA) and vitamin B6 (VB6) reduces levels of homocysteine.

High levels of CRP lead to a higher risk of exacerbations in chronic obstructive pulmonary disease (COPD).

Intake of folic acid (FA) and vitamin B6 (VB6) increases levels of homocysteine.

40mg/day dosage of folic acid and 2mg/day dosage of vitamin B12 does not affect chronic kidney disease (CKD) progression.

Mice lacking Sirt1 in Sf1-expressing neurons have increased susceptibility to diet-induced obesity and insulin resistance.

Exercise reduces cancer mortality rates among Chinese citizens.

Exercise increases cancer mortality rates among Chinese citizens.


Chinese individuals with TT homozygosity in the MTHFR gene are more vulnerable to strokes caused by low levels of folate intake.

Sn is present on mature DCs during inflammation in vivo.

Individuals with low serum vitamin D concentrations have decreased risk of multiple sclerosis.

Low nucleosome occupancy correlates with high methylation levels across species.

β-sheet opening occurs during pleurotolysin pore formation.

EGR2 is important to myelination of the peripheral nervous system.

Most termination events in Okazaki fragments are dictated by initiation patterns.

Tuberculosis-induced granulomas express different immune system protein signatures than the surrounding tissue.

Pharmacist attendance at ward rounds increases adverse events in wards.

The DdrB protein from Deinococcus radiodurans functions as a pentamer.


Chlamydia trachomatis is most prevalent in the UK among individuals in their 50s and 60s.

CD44v6 is not associated with constitutive and reprogrammed cancer stem cells driving cancer metastasis.

A T helper 2 cell (Th2) environment impedes disease development in patients with systemic lupus erythematosus (SLE).

Ultrasound guidance significantly reduces the number of traumatic procedures when attempting needle insertion.

Bone Marrow (BM) transplantation is used to treat acute myeloid leukemia (AML)

Primary cervical cancer screening with HPV detection has lower longitudinal sensitivity than conventional cytology to detect cervical intraepithelial neoplasia grade 2.

IFIT1 speeds viral replication by allowing for the proliferation of mis-capped viral RNAs.

Medications to treat obesity do not have side effects.

Neutrophil extracellular trap (NET) antigens may contain the targeted autoantigens PR3 and MPO.

siRNA knockdown of A20 slows tumor progression in an in vivo murine xenograft model.

Polymeal nutrition increases cardiovascular mortality.

Chlamydia trachomatis is most prevalent in the UK among sexually-experienced individuals aged 16 to 24.

Tuberculosis incidence occurs at higher rates in more sparsely populated areas in the UK.

Incidence of 10/66 dementia is lower than the incidence of DSM-IV dementia.

Incidence of 10/66 dementia is higher than the incidence of DSM-IV dementia.

Ten percent (10%) of kidney cancers in the UK are attributable to excess weight.

Approximately 250,000 people are infected with human T-cell lymphotropic virus type 1 in the United Kingdom.

Female carriers of the Apolipoprotein E4 (APOE4) allele have decreased risk for dementia.

In the UK, drowning affects boys and girls equally.

Incidence of sepsis has fallen substantially from 2009 to 2014.


Chlamydia trachomatis is most prevalent in the UK among sexually-experienced individuals aged 16 to 24.

Distant CREs are important for transcriptional regulation.

Chenodeoxycholic acid treatment increases brown adipose tissue activity.

Oxidative phosphorylation is one of the primary glycometabolic pathways in cells.

Hypocretin neurones suppress panicprone state in rats.

In transgenic mice harboring green florescent protein under the control of the Sox2 promoter, more than 50 percent of the cells with green florescent colocalize with cell proliferation markers.

Mice that lack Interferon-γ or its receptor are highly susceptible to experimental autoimmune myocarditis.

ATM and Rad3 related protein are critical for sensing DNA damage.

In British Men, haplogroup I decreases risk of cardiovascular disease.

Crossover hot spots are found within gene promoters in Saccharomyces cerevisiae.

Sildenafil worsens erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.

The peak incidence of fractures occurs during pubertal growth spurt in early adolescents.

Bacterial meningitis can be diagnosed on the basis of positive cerebrospinal fluid (CSF) cultures.

Female carriers of the Apolipoprotein E4 (APOE4) allele have shorter lifetime exposure to estrogen due to a decreased reproductive period.

The peak incidence of fractures occurs in toddlers.

Female carriers of the Apolipoprotein E4 (APOE4) allele have longer lifetime exposure to estrogen due to an increased reproductive period.


Cholesterol loading induces KLF4 expression in VSMCs, resulting in the expression of pro-inflammatory cytokines.

Microcin J25 inhibits nucleoside triphosphate (NTP) binding.

A strong bias in the phage genome locations where the spacers were derived has been observed in many CRISPR subtypes that confer the immunity to phage.

Deletion of ATM and Rad3 related protein is not predictive of acute tissue loss.

Cyclin A2 destruction is necessary to switch from unstable to stable kt-mt attachments in mitosis.

The HSV-2 infection is typically asymptomatic.

HOXB4 is a highly expressed component of cellular secretome from fetal liver cell populations.

Carriers of HNF4A mutations are at reduced risk for diabetes.

Birth-weight is negatively associated with breast cancer.

Metastatic colorectal cancer treated with a single agent fluoropyrimidines resulted in similar efficacy and better quality of life when compared with oxaliplatin-based chemotherapy in elderly patients.

DMS3 protein enables Pol V transcription in vivo.

Primary pro-inflammatory cytokines suppress secondary pro- and anti-inflammatory mediators.

KLF4 is necessary for VSMCs to gain genetic characteristics of other cell types within atherosclerotic lesions.

Pro-inflammatory cytokines are up regulated during tumor development.

Tumor development occurs in conjunction with upregulation of pro-inflammatory cytokines.

The cytokine receptor which regulates chemotaxis and formation of lymph nodes is involved in production of myeloperoxidase in the left atrium.

Pro-inflammatory cytokines are up repressed during tumor development.

Tumor development occurs in conjunction with suppression of pro-inflammatory cytokines.

CD28 signals regulate trafficking of murine auto-reactive T cells into target tissues.

The density of cytokine receptor bearing cells has no effect on the distance over which cytokines act.


Chronic HIV stimulation of B cells leads to the premature exhaustion of B cells.

Eilat virus (EILV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in nonhuman primates.

Mice defective for deoxyribonucleic acid (DNA) polymerase m (polm) reveal increased sensitivity to ionizing radiation (IR).

The number of unfertilized oocytes in mated hermaphrodites increases with age.

Commelina yellow mottle virus (ComYMV) has three typical badnavirus ORFs, capable of encoding proteins 23, 15, and 216 kD.

Insulin decreases risk of severe kidney failure.

Chinese individuals with TT homozygosity in the MTHFR gene are less vulnerable to strokes caused by low levels of folate intake.

Gpr124 increases BBB breakdown in mouse models of ischemic stroke.

RUNX1 is downregulated or mutated in TLX1 T-ALL.

Taxation of sugar-sweetened beverages reduced the incidence rate of type II diabetes in India.

Lamins are found within the inner layer of the nuclear membrane of all cells.

Exhaustion of B cells contributes to poor Ab response in HIV-infected individuals.

Antiretroviral therapy increases rates of tuberculosis across a broad range of CD4 strata.

Having a main partner worsens HIV outcomes.

Patients in stable partnerships progress from HIV to death at the same rate as patients not in partnerships.

Tuberculosis-induced granulomas express different immune system protein signatures than the surrounding tissue.

Rising temperatures caused by global warming increases risk of dengue fever transmission.

Rising temperatures caused by global warming lowers the risk of dengue fever transmission.

A low percentage of hematopoietic progenitor cells are susceptible to HIV-1 infection ex vivo.

The deregulated and prolonged activation of monocytes has deleterious effects in chronic infectious conditions.


Cis-acting lncRNAs control the expression of genes that are positioned in the vicinity of their transcription sites.

The generation of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells.

Self-advocacy training is effective at decreasing homelessness.

There is a positive correlation between hip fractures and statin use.

Deltex interacts with eIF3. There is no known interaction between Deltex and elF3

Perigenital skin is not the primary site of HIV acquisition.

Beta-band coherence is enhanced for visible stimuli over invisible stimuli.

Suboptimal nutrition is a leading cause of premature death

Thiopurine active metabolites can be catabolized through dephosphorylation of thioguanine nucleotides.

Mice without IFN-γ or its receptor are highly susceptible to EAM induced with α-MyHC/CFA.

Albendazole is used to treat soil-transmitted helminths.

Trans-acting factors, such as lncRNAs, influence mRNA translation.

Long - range chromatin interactions regulate transcription.

Distant CREs are important for transcriptional regulation.

CCL19 is predominantly present within dLNs.

Concentrations of SNV and CNV in stem-cell regulatory elements and binding sites of transcription factors in iPSC-lines are distinct from their founding cells.

miRNAs enforce homeostasis by suppressing low-level ''leaky'' transcription.

Lamins are found within the inner layer of the nuclear membrane of all cells.

Lamins are associated with nuclear membrane structure maintenance.

JMJD6 catalyzes the hydroxylation of C-terminal lysine and supresses transcriptional activity.


Citrullinated proteins externalized in neutrophil extracellular traps act indirectly to disrupt the inflammatory cycle.

DRD1 proteins enable Pol V transcription in vivo.

Increased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm.

Microcin J25 encourages nucleoside triphosphate (NTP) binding.

Cellular clocks are not predictive of mitosis timing in NIH 3T3 cells.

Vitamin D is an important factor in the relationship between calcium and parathyroid hormone.

The DEXI promoter region is bound by multiple transcription factors in a murine haematopoietic progenitor cell line.

The DESMOND program demonstrates no significant impact on weight loss.

Mice defective for deoxyribonucleic acid (DNA) polymerase I (polI) fail to reveal increased sensitivity to ionizing radiation (IR).

miRNAs enforce homeostasis by suppressing low-level ''leaky'' transcription.

R2D2 stops miRNA production by increasing the selectivity of Dcr2 for long dsRNA.

Citrullinated proteins externalized in neutrophil extracellular traps act indirectly to perpetuate the inflammatory cycle via induction of autoantibodies.

Neutrophils produce IL-1β in response to large particles.

Inhibiting focal adhesion formation increases the rate at which cells convert mechanical strain into inflammation and fibrosis.

Neutrophil extracellular trap (NET) antigens may contain the targeted autoantigens PR3 and MPO.

The tissue surrounding the granuloma in an immune cell induces an anti-inflammatory immune response.

Enhanced early production of inflammatory chemokines damages viral control in the lung.

Tuberculosis-induced granulomas express different immune system protein signatures than the surrounding tissue.

Ethanol stress increases the expression of SRL in bacteria.

Primary pro-inflammatory cytokines suppress secondary pro- and anti-inflammatory mediators.


Citrullinated proteins externalized in neutrophil extracellular traps act indirectly to perpetuate the inflammatory cycle via induction of autoantibodies.

British male students are bullied more than British female students.

Replacement of histone H2A with H2A.Z accelerates gene activation in yeasts by destabilizing +1 nucleosomes.

Depletion of nitric oxide is responsible for vasospasm.

Glucose restriction to 0.05% reduces RLS (replicative life span) by 20-40% in S. cerevisiae.

The RANK-RANK-Ligand (RANKL) pathway is involved in the development of Aire-expressing medullary thymic epithelial cells (mTECs).

Reducing H3k4me3 methylation induces mouse epiblast stem cells to naive pluripotency efficiently.

Inside the body, falciparum parasites reproduce asexually.

Decreased conversion of PGE 2 to PPARy ligand 15-ket-PGE 2 causes accumulation of PGE.

The DESMOND program demonstrates no significant impact on lifestyles outcomes.

Microcin J25 inhibits nucleoside triphosphate (NTP) binding.

During the primary early antibody response activated B cells migrate toward the inner-and outer follicular areas where oxysterol accumulation is generated by stromal cells.

Helicobacter pylori-induced aberrant NF-kB-dependent expression of activation-induced cytidine deaminase contributes to the mutagenesis of host DNA.

Upon viral challenge, influenza-specific memory CD4+ T cells greatly diminish the early production of inflammatory chemokines in the lung.

Oxidative DNA damage activates STING signalling.


Clathrin stabilizes the spindle fiber apparatus during mitosis.

ScPif1p has higher binding ability to G-rich ssDNA than to non-G-rich ssDNA.

There is no known interaction between Pioneer factor OCT3/4 and major chromatin remodeling factors.

Rapid phosphotransfer rates are correlated with histidine kinase regulator specificity.

Ribosomal protein (RP) expression is controlled in part by stress-activated regulators.

Systemic immunosuppressive (IS) therapy does not enhance the chance of cancer mortality in patients with inflammatory eye disease (IED)

In S. cerevisiae, the absence of RNA surveillance pathways causes sensitivity to high iron conditions.

Glycan adaptation involves insertion-deletion events.

Cancer cells can stimulate the accumulation of intra-tumoural myeloid-derived suppressor cells by promoting granulocyte colony stimulating factor production.

Side effects associated with antidepressants increases risk of stroke.

PrimPol generates short DNA replication intermediates on the leading strand during DNA replication.

Mitochondria play a major role in energy production.

Lamins have no effect on nuclear membrane structure maintenance.

Mitochondria play a major role in apoptosis.

PrimPol degrades short DNA replication intermediates on the leading strand during DNA replication.

Mitochondria play a trivial role in calcium homeostasis.

Lamins are found within the inner layer of the nuclear membrane of all cells.

The microtubule-dependent delivery and secretion of matrix metalloproteases (MMPs) is partially responsible for the disassembly of adhesion sites.


Cnn1 recruitment varies with cell cycle timing.

Toll-like receptor (TLR) signaling is involved in the pathogenesis of human MDS.

Pediatric SCD patients with vaso-occlusive crisis show increased morphine use after breathing 80 ppm iNO for 4 hours.

Patients with common epithelial cancers  are more likely to have an emergency event as their first hospital admission if they live in resource-deprived areas.

Osteocytes have an essential role in G-CSF induced HSPC mobilization.

B3-Galectin increases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR.

Lmna knock-in models are appropriate for testing therapeutic approaches against Hutchinson-Gilford progeria syndrome (HGPS).

Lice attenuated SIV vaccines induce a stronger antigen-specific T cell response in lymph node cells.

Ethanol stress lowers the expression of PSP in bacteria.

Female carriers of the Apolipoprotein E4 (APOE4) allele have shorter lifetime exposure to estrogen due to a decreased reproductive period.

Lack of FGF21 in mice increases life expectancy.

Recognition of start codons depends on the translation initiation factor IF3.

Lack of FGF21 in mice leads to reduced lifespan.

The proliferative capacity of neural progenitors differs across species.

Cellular differentiation of embryonic stem cells is accompanied by changes in replication timing, transcription and nuclear localization.

Understanding epigenetic regulation of replication is essential for the reational design of episomally replicating vectors.

Dscam1 acts as a hypervariable pattern-recognition receptor for the immune system.

Forkhead 0 (fox0) transcription factors are involved in cellular differentiation.

Ly49Q directs the organization of neutrophil polarization by regulating membrane raft functions.


Cognitive behavioral therapy is an ineffective treatment for insomnia

CDK6 shows impaired binding to loss-of-function variants of p18 INK4C.

0-dimensional biomaterials lack inductive properties.

Satellite cell dysfunction is a key factor in sarcopenia development.

Tumor development occurs in conjunction with upregulation of pro-inflammatory cytokines.

Ethanol stress increases the expression of IBP in bacteria.

Increase of p62 in prostate tumor stroma results in defective autophagy.

Cholesterol loading induces KLF4 expression in VSMCs, resulting in the expression of pro-inflammatory cytokines.

Vaccinating the gastrointestinal tract induces protection of rectal and vaginal mucosa.

7-day-old adult Caenorhabditis elegans exhibit approximately 75% of the learning capacity seen in 1-day old adults.

Reducing H3k4me3 methylation induces mouse epiblast stem cells to naive pluripotency efficiently.

Headaches are correlated with cognitive impairment.

Antidepressants reduce the severity of migraines.

Side effects associated with antidepressants increases risk of stroke.

In young and middle-aged adults, current or remote uses of ADHD medications increase the risk of serious cardiovascular events.

Antidepressants increase the severity of migraines.

Sildenafil worsens erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.

Side effects associated with antidepressants do not represent a mortality risk to postmenopausal women.

Patients with panic anxiety show decreased CSF levels of hypocretin.

Amitriptyline is an effective treatment for chronic tension-type headaches.


Combination nicotine replacement therapies with varenicline or bupropion are more effective after 12 weeks of reatment compared to varenicline monotherapy.

The H2A-H2B eviction defect is compensated for by other histone chaperone(s).

Vitamin D is an important factor in the relationship between calcium and parathyroid hormone.

RUNX1 is downregulated or mutated in TLX1 T-ALL.

Men are more susceptible to death due to pneumonia when compared to women.

Transcription factor EB induces transcription of pro-inflammatory cytokines in macrophages infected with Staphylococcus aureus.

Up-regulation of the p53 pathway and related molecular events speeds cancer progression.

The generation of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells.

Whole brain radiotherapy increases the occurrence of new brain metastases.

ATM and Rad3 related protein are critical for sensing DNA damage.

Pioglitazone use is significantly associated with an increased risk of prostate cancer.

Varenicline monotherapy is more effective after 26 weeks of treatment compared to combination nicotine replacement therapies with varenicline or bupropion.

Antiretroviral therapy increases rates of tuberculosis across a broad range of CD4 strata.

Stroke patients with prior use of direct oral anticoagulants have a higher risk of in-hospital mortality than stroke patients with prior use of warfarin.

Side effects associated with antidepressants lower risk of myocardial infarction.

Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission.

A 100g dose of chloroquine chemoprophylactic regimen results in retinal toxicity after 1 year of weekly intake.


Commelina yellow mottle virus (ComYMV) has three typical badnavirus ORFs, capable of encoding proteins 23, 15, and 216 kD.

H4 G94P proteins induce degradation of free histones via Rad53-dependent mechanisms.

The one-child policy has created a hospitable environment for female infants.

Rising temperatures caused by global warming increases risk of dengue fever transmission.

Intake of folic acid (FA) and vitamin B6 (VB6) reduces levels of homocysteine.

Egr3 regulates the homeostasis of B and T cells.

Including pharmacists in rounding teams reduces the incidence of adverse drug events (ADEs).

Active Ly49Q induces neutrophil polarization.

miR-142-5P is a known regulator of raised body temperature.

Commelina yellow mottle virus' (ComYMV) genome consists of 2140 baise pairs.

Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 encourage West Nile virus replication in cortical neurons.

Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 inhibit West Nile virus replication in cortical neurons.

The PPR MDA5 has twenty N-terminal CARD domains.

Bacteriophagaes MS2 and Qβ are members of the Leviviridae.

Helminths interfere with immune system control of coinfections by microbial pathogens 16.

Eilat virus (EILV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in nonhuman primates.

Dscam1 acts as a hypervariable pattern-recognition receptor for the immune system.

The predominant localization of Linc00173 is in mononuclear macrophage nuclei.


Commelina yellow mottle virus' (ComYMV) genome consists of 2140 baise pairs.

Aged patients are more susceptible to ischaemia/reperfusion injury.

Ethanol stress reduces the expression of SRL in bacteria.

Taking 400mg of α-tocopheryl acetate does not prevent prostate cancer.

A high microerythrocyte count protects against severe anemia in homozygous alpha (+)- thalassemia trait subjects.

Mice without IFN-γ or its receptor are highly susceptible to EAM induced with α-MyHC/CFA.

Tuberculosis-induced granulomas express different immune system protein signatures than the surrounding tissue.

Cell autonomous sex determination in somatic cells occurs in Galliformes.

The proportion of people with visual difficulty is two times higher in low-income countries than in high-income countries.

Chemical injury represses transglutaminase 2 activity.

Active H. pylori urease has a polymeric structure consisting of five distinct subunits.

ScPif1p has higher binding ability to G-rich ssDNA than to non-G-rich ssDNA.


Comparative transcriptome analysis identified new platelet proteins with structural features suggesting a role in platelet function.

Stiff substrates encourage mesodermal differentiation by degrading beta-catenin in an integrin-dependent manner.

Citrullinated proteins externalized in neutrophil extracellular traps act indirectly to perpetuate the inflammatory cycle via induction of autoantibodies.

Cancer-associated fibroblasts (CAFs) interact with cancer cells to mediate formation and activation of CAFs.

Algerian physicians constitue the largest component of sub-Saharan Africa-trained physicians in the United States.

The PPR MDA5 has twenty N-terminal CARD domains.

Mutations in RIM1 raise levels of IME1 RNA.

Chlamydia trachomatis is most prevalent in the UK among individuals in their 50s and 60s.

Pre-mRNAs associated with spliceosomal components are more stable than unassociated splicing substrates.

Foxk2 regulates autophagy genes in muscle cells and fibroblast cells.

Active caspase-11 participate in regulating phagosome-lysosome fusion.

Binding of p53 to enhancer regions (p53BERs) regulates the activity of p53 transcription and cell cycle arrest through the production of p53-dependent eRNAs.

Many cytokines that are produced by cancer cells also contribute to carcinogenesis.

MEK inhibitors are effective treatments in RAS-driven mouse models of cancer.

Lack of FGF21 in mice leads to atherosclerotic plaque formation.

Many transmembrane receptors transmit signals by long-range conformational changes in the association of alpha-helices across the plasma membrane.

Intramembrane cleavage by signal peptide peptidase aids in the degradation of proteins with a complex membrane orientation.

Lack of FGF21 in mice slows the rate of atherosclerotic plaque formation.

r-protein chaperones are found in complexes with their r-protein binding partners.


Concentrations of SNV and CNV in stem-cell regulatory elements and binding sites of transcription factors in iPSC-lines are distinct from their founding cells.

90% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.

Blocking the interaction between TDP-43 and respiratory complex I proteins ND3 and ND6 prevents TDP-43-induced neuronal loss.

Glycan adaptation is rarely observed in the B-cell repertoire.

ATF4 is a general endoplasmic reticulum stress marker.

Helminths interfere with immune system control of coinfections by microbial pathogens 16.

Mitochondria play a trivial role in calcium homeostasis.

Gastric infection with Helicobacter pylori increases risk of gastric cancer in humans.

miRNAs regulate a unique suite of mRNAs to maintain homeostasis in cells.

Retinoic acid receptor-related orphan receptor gamma (RORγ) is a therapeutic target for castration-resistant prostate cancer (CRPC)

Lipopolysaccharides have an inflammation independent effect on kidney barrier function.

Cis-acting lncRNAs control the expression of genes that are positioned in the vicinity of their transcription sites.

Distant CREs are important for transcriptional regulation.

Long - range chromatin interactions regulate transcription.

Pre-mRNAs associated with spliceosomal components are more stable than unassociated splicing substrates.

Pre-mRNAs associated with spliceosomal components are less stable than unassociated splicing substrates.

Overexpressing Cnp1 N-tail variants exacerbates the temperature-sensitive growth defect of scm3-139.

The DEXI promoter region is bound by multiple transcription factors in a murine haematopoietic progenitor cell line.


Consumption of whole fruits increases the risk of type 2 diabetes.

Normal granulomas form in the absence of TNF in Zebrafish.

PKG-la does not have a large impact on expression of pain hypersensitivity in PGK-la knockout mice.

1-1% of colorectal cancer patients are diagnosed with regional or distant metastases.

Pyridostatin reduces proliferation of homologous recombination - defective cells.

Patients in stable partnerships have a slower progression from HIV to AIDS.

Cell autonomous sex determination in somatic cells occurs in Galliformes.

Mice lacking Sirt1 in Sf1-expressing neurons have increased susceptibility to diet-induced obesity and insulin resistance.

Moderate consumption of candy and chocolate reduces the risk of cardiovascular disease (CVD).

Taxation of sugar-sweetened beverages reduced the incidence rate of type II diabetes in India.

It is not proven that moderate consumption of candy and chocolate reduces the risk of cardiovascular disease (CVD) specifically.

Autophagy deficiency in the liver increases vulnerability to insulin resistance.

Medications to treat obesity have unwanted side effects.

Medications to treat obesity do not have side effects.

Suboptimal nutrition is a leading cause of premature death

The risk of cancer rises with level of alcohol consumption.


Continued HHV-8 transmission among MSM in San Francisco may be explained by urogenital contact.

Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection increases dissemination of Salmonella Typhimurium from the gut.

Satellite cell dysfunction is a key factor in sarcopenia development.

In rhesus macaques, daily subcutaneous injections of tenofovir protects against rectally transmitted simian-human immunodeficiency virus.

Antimicrobial agents are more effective due to the pressure of antimicrobial usage.

Rhythmic expression of Cry1 translates directly into a circadian regulation of cAMP signaling in hepatic glucose metabolism.

Individuals with low serum vitamin D concentrations have decreased risk of multiple sclerosis.

The PDPN gene deactivates the C-type lectin receptor (CLEC-2).

Tonic signaling from the scFv is amplified by MyD88/CD40.

32% of liver transplantation programs required patients to discontinue methadone treatment in 2001.

Physical activity level is associated with the difference in maximal oxygen consumption between black and white youth.

The HSV-2 infection is typically asymptomatic.

Chlamydia trachomatis is most prevalent in the UK among sexually-experienced individuals aged 16 to 24.

Bacterial meningitis can be diagnosed on the basis of positive cerebrospinal fluid (CSF) cultures.

Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection decreases dissemination of Salmonella Typhimurium from the gut.

Urbanization is an important risk factor related to the transmission of dengue fever.

Toll-like receptor (TLR) signaling is involved in the pathogenesis of human MDS.

In rhesus macaques, daily subcutaneous injections of emtricitabine are ineffective at protecting against rectally transmitted simian-human immunodeficiency virus.

Pediatric SCD patients with vaso-occlusive crisis show increased morphine use after breathing 80 ppm iNO for 4 hours.


Converting apoE4 to apoE3 by gene editing prevents the pathology associated with apoE4 in human iPSCderived neurons.

Mitochondria play a major role in apoptosis.

Sympathetic nerve activity is reduced throughout normal pregnancy.

T cell receptor /CD3 microdomains are required to induce the immunologic synapse.

Omnivores produce less trimethylamine N-oxide from dietary I-carnitine than vegans.

The one-child policy has created a hospitable environment for female infants.

Splenomegaly is observed in knockin mouse lacking the SHP-2 MAPK pathway.

Antidepressants increase the severity of migraines.

The G34R/V mutation does not create a hypomethylated phenotype at the H3K36 histone.

APOE4 expression in iPSC-derived neurons results in decreased tau phosphorylation.

Converting apoE4 to apoE3 by gene editing worsens the pathology associated with apoE4 in human iPSCderived neurons.

MeCP2 influences the synaptic maturation of neurons.

p16INK4A degradation is  linked to an abnormal wound response caused by the microinvasive step of advanced Oral Potentially Malignant Lesions (OPMLs).

FoxO3a activation in neuronal death is inhibited by reactive oxygen species (ROS).

PKG-la plays an essential role in expression of spinal long term potentiation in PGK-la knockout mice.

PKG-la does not have a large impact on expression of spinal long term potentiation in PGK-la knockout mice.

ER-localized phosphatase Sac1 processes PI4P through coordination with OSBP and the endosome-localized protein sorting nexin 2.

Reduced phosphorylation of PP2A increases HDAC4 dephosphorylation by enhancing PP2A-HDAC4 interaction.


Converting apoE4 to apoE3 by gene editing worsens the pathology associated with apoE4 in human iPSCderived neurons.

L3MBTL2 binds to H2AK119Ub marked chromatin to form a PRC1 complex.

Ribosomopathies have a high degree of cell and tissue specific pathology.

There is no association between HNF4A mutations and diabetes risks.

Most termination events in Okazaki fragments are dictated by initiation patterns.

Cytosolic proteins bind to iron-responsive elements on mRNAs coding for TFRC1.

The proliferative capacity of neural progenitors differs across species.

Alirocumab treatment reduces apo(a) fractional clearance rate.

Expression of MSX2 is induced 3 hours after the addition of BMP4, which is earlier than T and CDX2.

TNFAIP3 is a glioblastoma tumor enhancer.

Activation of PPM1D enhances p53 function.

Reduced phosphorylation of PP2A suppresses HDAC4 dephosphorylation.


Cost effectiveness evaluations based on cRCT data accurately reflect prices for patients in actual clinical practice.

Physical injury represses transgultaminase activity.

Ca2+ cycling controls whole-body energy homeostasis in beige fat.

Omnivores produce less trimethylamine N-oxide from dietary I-carnitine than vegans.

Glioblastoma multiforme (GBM) is characterized by extensive invasion, rapid growth, necrosis, and angiogenesis.

Oxidative DNA damage inhibits STING signalling.

Fibroblast growth factor 21 protects against atherosclerosis by modulating adiponectin and SREBP2 levels.

The cytokine receptor which regulates chemotaxis and formation of lymph nodes is involved in production of myeloperoxidase in the left atrium.

Rapid phosphotransfer rates are correlated with histidine kinase regulator specificity.

The effect of Lipopolysaccharides on kidney barrier function is dependent on inflammation levels.

Antimicrobial agents are less effective due to the pressure of antimicrobial usage.

Cost effectiveness evaluations based on cRCT data lack external validity.

Measuring routine outcomes is more beneficial to clinical practice than assessing treatment adherence.

Assessing treatment adherence is more beneficial to clinical practice than measuring routine outcomes.

Risk-adjusted mortality rates are similar in teaching and non-teaching hospitals.

Including pharmacists in rounding teams reduces the incidence of adverse drug events (ADEs).

Including pharmacists in rounding teams does not alter the incidence of adverse drug events (ADEs).

Weighed food records (WFR) result in poor completion since they're costly to run and impose high participant burden.

Weighed food records (WFR) result in high completion since they're cheap to run and impose low participant burden.

Therapeutics receiving accelerated approval encounter a lower frequency of post-marketing safety events


Cost effectiveness evaluations based on cRCT data lack external validity.

Mutations in G-Beta protein GNB1 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.

Aged patients are less susceptible to ischaemia/reperfusion injury.

Activated Cdk5 phosphorylates the ATM protein in response to DNA damage.

British female students are bullied more than British male students.

Nonhuman primates are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.

RANK-RANKL pathway signalling has no known association with development of Aire-expressing medullary thymic epithelial cells.

Mice are incapable of producing neutralizing antibodies in reponse to the Chikungunya virus (CHIKV) produced in mosquitos.

Transcription factor EB induces transcription of pro-inflammatory cytokines in macrophages infected with Staphylococcus aureus.

Pre-mRNAs associated with spliceosomal components are less stable than unassociated splicing substrates.

In transgenic mice harboring green florescent protein under the control of the Sox2 promoter, more than 50 percent of the cells with green florescent colocalize with cell proliferation markers.

Integrated care is ineffective at tackling multiple comorbidities.


Crossover hot spots are found within gene promoters in Saccharomyces cerevisiae.

H.pylori-mediated gastric cancer occurs due to the accumulation of mutations in host epithelial cells.

The proliferative capacity of progenitors is regulated cell-autonomously.

Progerin induces premature aging in stem cells.

Expression of MSX2 is induced 3 hours after the addition of BMP4, which is earlier than T and CDX2.

Lamins are found within the inner layer of the mitochondrial membrane of all cells.

Occipital activation levels are associated with auditory spatial performance in parietal regions of the brain.

Insulin decreases risk of severe kidney failure.

Ca2+ cycling controls whole-body energy homeostasis in beige fat.

RTEL1 interacts with TRF2 through a C4C4 motif

siRNA knockdown of A20 slows tumor progression in an in vivo murine xenograft model.

In domesticated populations of Saccharomyces cerevisiae, segmental aneuploidy occurs infrequently.

In domesticated populations of Saccharomyces cerevisiae, segmental aneuploidy is very common.

The Snf1 complex regulates carbon and energy metabolism in baker's yeast (Saccharomyces cerevisiae).

A strong bias in the phage genome locations where the spacers were derived has been observed in many CRISPR subtypes that confer the immunity to phage.

Long - range chromatin interactions regulate transcription.

Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 inhibit West Nile virus replication in cortical neurons.

Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 encourage West Nile virus replication in cortical neurons.

Cis-acting lncRNAs control the expression of genes that are positioned in the vicinity of their transcription sites.

The latent infection of myeloid cells with human cytomegalovirus induces a number of changes in gene expression.


Cyclin A2 destruction is necessary to switch from unstable to stable kt-mt attachments in mitosis.

Aged patients are more susceptible to ischaemia/reperfusion injury.

Certain immunomodulator-human dialyzable leukocyte extract (hDLE) peptides are recognized by toll-like receptors (TLRs) on macrophages and dendritic cells.

Asymptomatic visual impairment screening in elderly populations leads to improved vision.

Pyridostatin deregulates G2/M progression.

Venules have less significant tunica adventitia than arterioles.

Ribosomopathies have a high degree of cell and tissue specific pathology.

Flexible molecules experience less steric hindrance in the tumor microenviroment than rigid molecules.

The deamination of cytidine to uridine on the minus strand of viral DNA can inactivate the viral genome by inducing G-to-A mutations.

The amount of publicly available DNA data doubles every 10 months.

Mitochondria play a trivial role in calcium homeostasis.

Mitochondria play a major role in apoptosis.

Clathrin stabilizes the spindle fiber apparatus during mitosis.

Mitochondria play a major role in energy production.

Alteration of origin firing causes changes in termination zones of Okazaki fragments.

Cytochrome c is transferred from cytosol to the mitochondrial intermembrane space during apoptosis.

Cellular clocks are not predictive of mitosis timing in NIH 3T3 cells.

MT binding domain drives amyloid structure formation.

siRNA knockdown of A20 slows tumor progression in an in vivo murine xenograft model.


Cytochrome c is transferred from cytosol to the mitochondrial intermembrane space during apoptosis.

Human embryonic stem cells give rise to cell types from all three embryonic germ layers.

TNFAIP3 is a glioblastoma tumor enhancer.

Repressing IL-18 has negative effects on atherosclerotic lesion composition and progression.

B cells go though plasmablast differentiation and antibody production by continuous expression of EBI2.

Overexpressing Cnp1 N-tail variants rescues the temperature-sensitive growth defect of scm3-139.

Mice that lack Interferon-γ or its receptor are highly susceptible to experimental autoimmune myocarditis.

The density of cytokine receptor bearing cells affects the distance over which cytokines act.

A deficiency of vitamin B12 decreases blood levels of homocysteine.

Taxation of sugar-sweetened beverages reduced the incidence rate of type II diabetes in India.

Immune complex triggered cell death leads to sequestration of oxidized mitochondrial DNA.

BCL-2 activation antagonizes the apoptotic effects of c-Myc.

The deamination of cytidine to uridine on the minus strand of viral DNA can inactivate the viral genome by inducing G-to-A mutations.

Oxidative phosphorylation is one of the primary glycometabolic pathways in cells.

BCL-2 promotes the apoptotic effects of c-Myc.

Activated Cdk5 regulates DNA damage-induced neuronal death.

Reduced phosphorylation of PP2A increases HDAC4 dephosphorylation by enhancing PP2A-HDAC4 interaction.


Cytosolic proteins bind to iron-responsive elements on mRNAs coding for TFRC1.

British male students are bullied more than British female students.

Type 1 Diabetes is associated with subtle perturbations in T reg development.

Sequence conservation in gene regulatory regions between species is a high-accuracy predictor of conserved functionality.

Inhibiting HDAC6 increases survival of mice with ARID1A mutated tumors.

Bone Marrow (BM) transplantation is used to treat acute myeloid leukemia (AML)

Human embryonic stem cells give rise to cell types from the outer embryonic germ layer, but not the other two layers.

PRC1-bound plasmids sediment at a slower rate in unbound plasmids than in sucrose gradients.

The H2A-H2B eviction defect is compensated for by other histone chaperone(s).

In S. cerevisiae, the absence of RNA surveillance pathways causes sensitivity to high iron conditions.

In S. cerevisiae, the absence of RNA surveillance pathways reduces sensitivity to high iron conditions.

Egr2 regulates the homeostasis of B and T cells.

Mitochondria play a trivial role in calcium homeostasis.

Egr3 regulates the homeostasis of B and T cells.

A deficiency of folate increases blood levels of homocysteine.

APOE4 expression in iPSC-derived neurons results in decreased tau phosphorylation.

Osteocytes have an essential role in G-CSF induced HSPC mobilization.

Transcription factor EB induces transcription of pro-inflammatory cytokines in macrophages infected with Staphylococcus aureus.


DMS3 protein enables Pol V transcription in vivo.

Nonsteroidal antinflammatory drugs are ineffective as cancer treatments.

Adult tissue-resident macrophages are seeded before birth.

Pyridostatin reduces proliferation of homologous recombination - defective cells.

M. stadtmanae does not induce ASC speck formation in BlaER1 monocytes.

Genes involved in pre-mRNA splicing have a significant impact on genome stability.

Immune complex triggered cell death leads to extracellular release of nuclear DNA.

BRCA 1 mutation carriers' risk of breast and ovarian cancer depends on where the mutation is located.

Bariatric surgery reduces postmenopausal breast cancer.

Foxk2 regulates autophagy genes in muscle cells and fibroblast cells.

DRD1 proteins enable Pol V transcription in vivo.

LSD1-positive promoters are associated with RNA polymerase II

JMJD6 catalyzes the hydroxylation of C-terminal lysine and supresses transcriptional activity.

The PRDM1 gene, when combined with the PRDM14 gene, plays an important role during primordial germ cell specification.

Foxp3 enables the expression of transcriptional regulators implicated in memory T cell development.

ER-localized phosphatase Sac1 processes PI4P through coordination with OSBP and the endosome-localized protein sorting nexin 2.

Binding of p53 to enhancer regions (p53BERs) regulates the activity of p53 transcription and cell cycle arrest through the production of p53-dependent eRNAs.

TNFAIP3 is a glioblastoma tumor suppressor.

PKG-la plays an essential role in expression of spinal long term potentiation in PGK-la knockout mice.


DRD1 proteins enable Pol V transcription in vivo.

Energy balance requires hypothalamic glutamate neurotransmission.

Walking in traffic areas in London did not improve lung function in elderly adults.

The M2-phenotype in brown adipose tissue macrophages increases brown adipose tissue thermogenic activity.

Activated Cdk5 regulates DNA damage-induced neuronal death.

Beta-band coherence is diminished for visible stimuli over invisible stimuli.

r-protein chaperones are found in complexes with their r-protein binding partners.

FACT and other histone chaperone(s) compensate for Histone 2A (H2A)-histone 2B (H2B) dimer eviction during the histone exchange process.

Ten percent (10%) of kidney cancers in the UK are attributable to excess weight.

Self-advocacy training is effective at decreasing homelessness.

Roughly 55% of women with chronic pelvic pain have no underlying pathology.

The repeat-variable diresidue (RVD) in the loop of Transcription-Activator Like (TAL) effectors specifies the nucleotides-amino acid contact at the target promoter element.

The PRDM1 gene is a key determinant of primordial germ cells.

Active caspase-11 participate in regulating phagosome-lysosome fusion.

Distant CREs are important for transcriptional regulation.


Commelina yellow mottle virus' (ComYMV) genome consists of 2140 baise pairs.

Mice lacking Sirt1 in Sf1-expressing neurons are immune to diet-induced obesity and insulin resistance.

The PRDM1 gene is a key determinant of primordial germ cells.

RUNX1 is downregulated or mutated in TLX1 T-ALL.

Incidence of 10/66 dementia is lower than the incidence of DSM-IV dementia.

TNFAIP3 is a glioblastoma tumor suppressor.

There is no increased risk of hypospadias with clomiphene.

Patients with microcytosis and higher erythrocyte count are more vulnerable to severe malarial anaemia when infected with Plasmodium falciparum.

Adult tissue-resident macrophages stem from the embryonal yolk sac and fetal liver.

Ultrasound guidance significantly reduces the number of needle insertion attempts necessary for a given procedure.

DUSP4 downregulation deactivates the Ras-ERK pathway

Reduced phosphorylation of PP2A suppresses HDAC4 dephosphorylation.

Reduced phosphorylation of PP2A increases HDAC4 dephosphorylation by enhancing PP2A-HDAC4 interaction.

Activation of PPM1D enhances p53 function.

PD-1 triggering on monocytes enhances IL-10 production by monocytes.

Deltex has no known interactions with eIF3f.

Reduced levels of lipolysis leads to higher P38 phosphorylation in adipose tissue.

Increased lipolysis leads to higher P38 phosphorylation in adipose tissue.


DUSP4 downregulation deactivates the Ras-ERK pathway

Immune responses in immune cells are geographically segregated.

Insulin decreases risk of severe kidney failure.

Having a main partner improves HIV outcomes.

MEK inhibitors are effective treatments in RAS-driven mouse models of cancer.

M. stadtmanae does not induce ASC speck formation in BlaER1 monocytes.

Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission.

In young and middle-aged adults, current or remote uses of ADHD medications increase the risk of serious cardiovascular events.

MT binding domain drives amyloid structure formation.

Retinoic acid receptor-related orphan receptor gamma (RORγ) is a therapeutic target for castration-resistant prostate cancer (CRPC)


An M2-like phenotype in brown adipose tissue macrophages is quickly induced by cold exposure.

Upon viral challenge, influenza-specific memory CD4+ T cells greatly enhance the early production of inflammatory chemokines in the lung.

Ethanol stress increases the expression of IBP in bacteria.

Occipital activation levels are associated with auditory spatial performance in parietal regions of the brain.

In rhesus macaques, daily subcutaneous injections of tenofovir protects against rectally transmitted simian-human immunodeficiency virus.

Moderate consumption of candy and chocolate reduces the risk of cardiovascular disease (CVD).

Omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegetarians.

The tissue surrounding the granuloma in an immune cell induces an anti-inflammatory immune response.

Increased mobility of retrotransposons is assosciated with mutation and higher tumorigenesis rates.


De novo assembly of sequence data has fewer specific contigs than unassembled sequence data.

RUNX1 is downregulated or mutated in TLX1 T-ALL.

CDK6 shows improved binding to loss-of-function variants of p18 INK4C.

Interleukin-18 plays an important role in the pathogenesis of atherosclerosis.

Origin gross domestic product(GDP) is positively related to dengue virus (DENV-1) diffusion in air traffic shipments.

Insulin decreases risk of severe kidney failure.

The combination of physical examinations with C-reactive protein values do not improve the accuracy of radiographic verified pneumonia predictions.

Having a main partner worsens HIV outcomes.

The World Health Organization's (WHO) data collection process is biased downward by unequal selection of larger outbreaks.

Many cytokines that are produced by cancer cells also contribute to carcinogenesis.

ATM and Rad3 related protein are critical for sensing DNA damage.

De novo assembly of sequence data has shorter contigs than unassembled sequence data.

Flexible molecules experience less steric hindrance in the tumor microenviroment than rigid molecules.

Understanding epigenetic regulation of replication is essential for the reational design of episomally replicating vectors.

0-dimensional biomaterials lack inductive properties.

Genes involved in pre-mRNA splicing have a significant impact on genome stability.

Mouse models can be generated using "artificial spermatids."

Sequence conservation in gene regulatory regions between species is a high-accuracy predictor of conserved functionality.

The amount of publicly available DNA data doubles every 10 months.

Pre-mRNAs associated with spliceosomal components are less stable than unassociated splicing substrates.


De novo assembly of sequence data has shorter contigs than unassembled sequence data.

Transcription rates in S. cerevisiae range between 0.7 and 2 kb/min.

Bacteriophagaes MS2 and Qβ are members of the Leviviridae.

Bone Marrow (BM) transplantation is used to treat acute myeloid leukemia (AML)

Pharmacist attendance at ward rounds reduces adverse events in wards.

Activated Cdk5 regulates DNA damage-induced neuronal death.

Lack of FGF21 in mice increases life expectancy.

53% of perinatal mortality is due to low birth weight.

Acute ablation of Snail in the embryonic cortex affects the proliferation and number of embryonic cortical precursors.

Monoclonal antibody targeting of N-cadherin encourages metastasis.


Decrease of p62 in prostate tumor stroma results in defective autophagy.

A strong bias in the phage genome locations where the spacers were derived has been observed in many CRISPR subtypes that confer the immunity to phage.

Smc5/6 engagment halts the activation of SUMO E3 ligase Mms21 by ATP-dependent remolding.

JMJD6 slows the hydroxylation of C-terminal lysine

Monoclonal antibody targeting of N-cadherin inhibits growth.

Omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegetarians.

Major antigen-induced signals from the T cell receptor and secondary signals from costimulatory receptors are required for T cell activation.

General exercise therapy is more effective than scapular stabilizer exercises in reducing pain and improving function of the shoulder.

PCSK9 inhibitors decrease plasma Lp(a) levels.

The effect of Lipopolysaccharides on kidney barrier function is dependent on inflammation levels.

Roughly 55% of women with chronic pelvic pain have no underlying pathology.

Increase of p62 in prostate tumor stroma results in defective autophagy.

Taking 400mg of α-tocopheryl acetate does not prevent prostate cancer.

Pioglitazone use is not associated with an increased risk of prostate cancer.

Taking 400mg of α-tocopheryl acetate in combination with vitamin C reduces the risk of prostate cancer.

Activation of PPM1D enhances p53 function.

Reduced levels of lipolysis leads to higher P38 phosphorylation in adipose tissue.

Increased lipolysis leads to higher P38 phosphorylation in adipose tissue.

Upregulation of PD1 causes the downmodulation of Satb1.

Upregulation of PD1 causes the upregulation of Satb1.


Decreased conversion of PGE 2 to PPARy ligand 15-ket-PGE 2 causes accumulation of PGE.

The DESMOND program demonstrates no significant impact on weight loss.

Helminths interfere with immune system control of coinfections by microbial pathogens 16.

The PRDM1 gene, when combined with the PRDM14 gene, plays an important role during primordial germ cell specification.

The combination of physical examinations with C-reactive protein values do not improve the accuracy of radiographic verified pneumonia predictions.

Elevated cell-free mitochondrial DNA levels are associated with mortality.

Exercise reduces cancer mortality rates among Chinese citizens.

Amitriptyline is an effective treatment for chronic tension-type headaches.

Differentiation of progenitor cells to myeloid cells is skewed when insulin signaling is suppressed.

Reduction of Rpl38 alters the composition of the Hox gene mRNAs translation in mice without lowering overall protein synthesis.

Increased conversion of PGE 2 to PPARy ligand 15-ket-PGE 2 causes accumulation of PGE.

High levels of CRP lead to a higher risk of exacerbations in chronic obstructive pulmonary disease (COPD).

PKG-la does not have a large impact on expression of pain hypersensitivity in PGK-la knockout mice.

Reduced phosphorylation of PP2A increases HDAC4 dephosphorylation by enhancing PP2A-HDAC4 interaction.

PGE 2 suppresss intestinal tumor growth by altering the expression of tumor suppressing and DNA repair genes.

Increased LDL receptors plays a role in the reduction of plasma Lp(a).

Reduced phosphorylation of PP2A suppresses HDAC4 dephosphorylation.

PCSK9 inhibitors decrease plasma Lp(a) levels.

There is no increased risk of hypospadias with clomiphene.


Decreased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm.

Upregulation of PD1 causes the upregulation of Satb1.

Rhythmic expression of Cry1 translates directly into a circadian regulation of cAMP signaling in hepatic glucose metabolism.

Microglia are an innate immune cell type of the peripheral nervous system.

In young and middle-aged adults, current or remote uses of ADHD medications increase the risk of serious cardiovascular events.

Cholesterol loading induces KLF4 expression in VSMCs, resulting in the expression of pro-inflammatory cytokines.

Participants who quit smoking reduce lung cancer risk by approximately 50%.

Traditional reviews are biased in their interpretations.

N348I mutations cause resistance to nevirapine.

MUC1-C activates the NF-κB p65 signaling pathway by interacting with IκB kinase ß.

The tissue surrounding the granuloma in an immune cell induces an anti-inflammatory immune response.

Increased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm.

Ambulatory blood pressure monitoring is inaccurate at diagnosing hypertension.

Sudden death can occur in patients with orthostatic hypertension without cardiac conduction abnormalities.

CRP is positively correlated with postoperative mortality following Coronary Artery Bypass Graft (CABG) surgery.

Sudden death can occur in patients with complex ventricular arrhythmias.

Diabetic patients with acute coronary syndrome experience decreased short-term and long-term risk for bleeding events.

AMP-activated protein kinase (AMPK) activation reduces inflammation-related fibrosis in the lungs.

Noninvasive positive pressure ventilation is not predictive of acute respiratory failure after solid organ transplantation.


L3MBTL2 binds to H2AK119Ub marked chromatin to form a PRC1 complex.

NR5A2 is important in reverse cholesterol transport in humans.

R2D2 stops miRNA production by increasing the selectivity of Dcr2 for long dsRNA.

Physical activity does not improve cognitive function in individuals with Alzheimers.

Patients with microcytosis and higher erythrocyte count are more vulnerable to severe malarial anaemia when infected with Plasmodium falciparum.

Foxk2 regulates autophagy genes in muscle cells and fibroblast cells.

The combination of physical examinations with C-reactive protein values do not improve the accuracy of radiographic verified pneumonia predictions.

Increase of p62 in prostate tumor stroma results in defective autophagy.

PTEN is a regulator for the transcriptional activity of SRF

G-CSF increases the expansion and infiltration of MDSCs into tumors.

Osteocytes have an essential role in G-CSF induced HSPC mobilization.

cSMAC formation represses weak ligand signalling.

Patients with panic anxiety show decreased CSF levels of hypocretin.

The deamination of cytidine to uridine on the minus strand of viral DNA can inactivate the viral genome by inducing G-to-A mutations.

MafA ubiquitination decreases the recruitment of coavtivator P/CAF by MafA.

ScPif1p has reduced binding ability to G-rich ssDNA compared to non-G-rich ssDNA.

Glycan adaptation involves insertion-deletion events.

MafA ubiquitination increases the recruitment of coavtivator P/CAF by MafA.


Deletion of ATM and Rad3 related protein is not predictive of acute tissue loss.

Monoclonal antibody targeting of N-cadherin encourages castration resistance.

Upregulation of dynein in Drosophila neurons increases the number of microtubule plus-ends growing toward the cell body of each neuron.

PKG-la plays an essential role in expression of spinal long term potentiation in PGK-la knockout mice.

Human embryonic stem cells give rise to cell types from the outer embryonic germ layer, but not the other two layers.

Vitamin D deficiency effects birth weight.

The generation of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells.

Myelin sheaths play a role in action potential propagation.

70% of burn patients are admitted for hospitalization and further treatment after appearing at hospital emergency wards or outpatient clinics.

Deletion of ATM and Rad3 related protein leads to acute tissue loss.

ATM and Rad3 related protein have no role in sensing DNA damage.

ATM and Rad3 related protein are critical for sensing DNA damage.

Activated Cdk5 phosphorylates the ATM protein in response to DNA damage.

Gpr124 suppresses BBB breakdown in mouse models of ischemic stroke.

MEK inhibitors are effective treatments in RAS-driven mouse models of cancer.

Sudden death can occur in patients with orthostatic hypertension without cardiac conduction abnormalities.

Gpr124 increases BBB breakdown in mouse models of ischemic stroke.

Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes epithelial damage.


Deletion of ATM and Rad3 related protein leads to acute tissue loss.

Stiff substrates inhibit mesodermal differentiation by degrading beta-catenin in an integrin-dependent manner.

HbA1c consistently overestimates glycemic control in black individuals with Sickle cell trait (SCT).

Improvements in OER catalysts show stable activity over several hundred hours.

Bariatric surgery reduces colorectal cancer.

Environmental factors can influence the development of breast cancer.

Whole brain radiotherapy increases the occurrence of new brain metastases.

Forkhead 0 (fox0) transcription factors are involved in cellular differentiation.

Bone Marrow (BM) transplantation is used to treat acute myeloid leukemia (AML)

Patients with microcytosis and higher erythrocyte count were more resistant to severe malarial anaemia when infected with Plasmodium falciparum.

Mouse models can be generated using "artificial spermatids."

Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes fibrosis.

Major vault protein (MVP) leads to more aggressive tumors by regulating the sorting of tumor suppressive miR-193a into extracellular vesicles (EVs).


Deltex has no known interactions with eIF3f.

Commelina yellow mottle virus (ComYMV) has three typical badnavirus ORFs, capable of encoding proteins 23, 15, and 216 kD.

Adult tissue-resident macrophages are seeded before birth.

LDL cholesterol has a causal role in the development of cardiovascular disease.

Side effects associated with antidepressants increases risk of stroke.

Tuberculosis-induced granulomas express different immune system protein signatures than the surrounding tissue.

Surfactin producing cells and exopolymer producing cells cooperate to generate "Van Gogh" bundles that have sliding abilities on specialized media.

VgrG (Tssl) protein punctures membranes by forming a spike at the tip of the tube apparatus.

Persistor cells are one reason for incomplete responses to Tyrosine kinase inhibitor (TKI) therapy in cancer patients.

Activation of the Rac1 homolog CED-10 kills viable cells in SRGP-1 mutant Caenorhabditis elegans.

Removal of H3K9me3 by ectopic expression of other H3K9 demethylases decreases reprogramming efficiency in SCNT experiments.

Deltex interacts with eIF3. There is no known interaction between Deltex and elF3

ScPif1p has reduced binding ability to G-rich ssDNA compared to non-G-rich ssDNA.

ScPif1p has higher binding ability to G-rich ssDNA than to non-G-rich ssDNA.

TNFAIP3 is a glioblastoma tumor suppressor.

ATF4 is a general endoplasmic reticulum stress marker.

The PPR MDA5 has twenty N-terminal CARD domains.

TNFAIP3 is a glioblastoma tumor enhancer.

MafA phosphorylation enhances its ubiquitination.


Deltex interacts with eIF3. There is no known interaction between Deltex and elF3

A diminished ovarian reserve is a very strong indicator of infertility, even in an a priori non-infertile population.

Allogeneic mechanical circulatory support is not as effective as autologous mechanical circulatory support for treating acute myocardial infarction.

In S. cerevisiae, the absence of RNA surveillance pathways causes sensitivity to high iron conditions.

Mice defective for deoxyribonucleic acid (DNA) polymerase I (polI) fail to reveal increased sensitivity to ionizing radiation (IR).

Lipopolysaccharides have an inflammation independent effect on kidney barrier function.

A 100g dose of chloroquine chemoprophylactic regimen results in retinal toxicity after 1 year of weekly intake.

Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection decreases dissemination of Salmonella Typhimurium from the gut.

Microcin J25 encourages nucleoside triphosphate (NTP) binding.

RTEL1 interacts with TRF2 through a C4C4 motif

The minor G allele of FOXO3 up-regulates IL-10.

EGR2 is important to myelination of the peripheral nervous system.

Egr3 regulates the homeostasis of B and T cells.

DUSP4 downregulation deactivates the Ras-ERK pathway

Recognition of start codons depends on the translation initiation factor IF3.

JMJD6 slows the hydroxylation of C-terminal lysine

IFI16 impedes STING phosphorylation and translocation, resulting in reduced activation of STING.