{"query_id": "0", "query_text": "0-dimensional biomaterials lack inductive properties.", "negative": "Rising temperatures caused by global warming increases risk of dengue fever transmission.", "negatives": ["Rising temperatures caused by global warming increases risk of dengue fever transmission.", "Osteoparthritis (OA) is characterized by degeneration of articular cartilage, joint edge, and subchondral bone hyperplasia.", "MFGE8 regulates fat absorption by binding to av-Beta3 and av-Beta5 integrins.", "Repressing IL-18 has negative effects on atherosclerotic lesion composition and progression.", "Up-regulation of the p53 pathway and related molecular events speeds cancer progression.", "ATF4 is a general endoplasmic reticulum stress marker.", "Consumption of whole fruits increases the risk of type 2 diabetes.", "Human embryonic stem cells give rise to cell types from the outer embryonic germ layer, but not the other two layers.", "MT binding domain drives amyloid structure formation.", "The NF-\u03baB essential modulator gene prevents intestinal inflammation by inhibiting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death."], "hard_negatives": ["0-dimensional biomaterials lack inductive properties.", "Flexible molecules experience less steric hindrance in the tumor microenviroment than rigid molecules.", "Myelin sheaths are lipid-rich cellular structures.", "Adult tissue-resident macrophages possess a self-renewing capacity.", "Mitochondria play a major role in energy production.", "Pure neural progenitor cell (NPC) populations can only be obtained from cell cultures that undergo passaging, filtration, or other isolation and cell sorting methods.", "The proliferative capacity of neural progenitors differs across species.", "Immune responses in immune cells are geographically segregated.", "Specialized functional cell types can be derived from human pluripotent stem cells.", "Bone marrow cells don't contribute to adult macrophage compartments."], "hard_negative": "0-dimensional biomaterials lack inductive properties."}
{"query_id": "2", "query_text": "1 in 5 million in UK have abnormal PrP positivity.", "negative": "Chinese individuals with TT homozygosity in the MTHFR gene are less vulnerable to strokes caused by low levels of folate intake.", "negatives": ["Chinese individuals with TT homozygosity in the MTHFR gene are less vulnerable to strokes caused by low levels of folate intake.", "Cellular differentiation of embryonic stem cells is accompanied by changes in replication timing, transcription and nuclear localization.", "5'-nucleotidase metabolizes 6MP.", "Pseudoknots are not evolutionarily conserved in most eukaryotes.", "5'-nucleotidase metabolizes 6MP.", "Cancers that initially benefit from epidermal growth factor receptor targeted therapies later become refractory through several mechanisms.", "Antimicrobial agents are less effective due to the pressure of antimicrobial usage.", "Sequence conservation in gene regulatory regions between species is a high-accuracy predictor of conserved functionality.", "In S. cerevisiae, the absence of RNA surveillance pathways reduces sensitivity to high iron conditions.", "The DESMOND program demonstrates no significant impact on biochemical outcomes."], "hard_negatives": ["1 in 5 million in UK have abnormal PrP positivity.", "Approximately 250,000 people are infected with human T-cell lymphotropic virus type 1 in the United Kingdom.", "High levels of CRP lead to a higher risk of exacerbations in chronic obstructive pulmonary disease (COPD).", "Sepsis related mortality has risen from 2009 to 2014.", "Incidence of sepsis has fallen substantially from 2009 to 2014.", "Neutrophil extracellular trap (NET) antigens may contain the targeted autoantigens PR3 and MPO.", "Decreased conversion of PGE 2 to PPARy ligand 15-ket-PGE 2 causes accumulation of PGE.", "Tuberculosis incidence occurs at higher rates in more sparsely populated areas in the UK.", "Increased conversion of PGE 2 to PPARy ligand 15-ket-PGE 2 causes accumulation of PGE.", "Sepsis related mortality has remained stable between 2009-2014."], "hard_negative": "1 in 5 million in UK have abnormal PrP positivity."}
{"query_id": "4", "query_text": "1-1% of colorectal cancer patients are diagnosed with regional or distant metastases.", "negative": "Patients with microcytosis and higher erythrocyte count are more vulnerable to severe malarial anaemia when infected with Plasmodium falciparum.", "negatives": ["Patients with microcytosis and higher erythrocyte count are more vulnerable to severe malarial anaemia when infected with Plasmodium falciparum.", "Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 encourage West Nile virus replication in cortical neurons.", "KRT17 modulates the expression of the transcriptional regulator AIRE in diseased epithelia.", "Pioglitazone use is not associated with an increased risk of prostate cancer.", "Deregulation of HAND2 is a crucial step in endometrial carcinogenesis in mice.", "T cell receptor /CD3 microdomains are required to induce the immunologic synapse.", "Thiopurine active metabolites can be catabolized through dephosphorylation of thioguanine nucleotides.", "Ca2+ cycling controls whole-body energy homeostasis in beige fat.", "MT binding domain drives amyloid structure formation.", "Natriuretic peptides increase susceptibility to diabetes."], "hard_negatives": ["61% of colorectal cancer patients are diagnosed with regional or distant metastases.", "1-1% of colorectal cancer patients are diagnosed with regional or distant metastases.", "Ten percent (10%) of kidney cancers in the UK are attributable to excess weight.", "Bariatric surgery reduces colorectal cancer.", "Bariatric surgery increases rates of colorectal cancer.", "At least 85% of patients exposed to radiation have activated markers of myofibroblasts.", "Metastatic colorectal cancer treated with a single agent fluoropyrimidines resulted in similar efficacy and better quality of life when compared with oxaliplatin-based chemotherapy in elderly patients.", "Cancer-associated fibroblasts (CAFs) have no known interaction with cancer cells in the formation and activation of CAFs.", "Less than 10% of patients exposed to radiation have activated markers of mesenchymal stem cells.", "ALDH1 expression is associated with poorer prognosis for breast cancer primary tumors."], "hard_negative": "61% of colorectal cancer patients are diagnosed with regional or distant metastases."}
{"query_id": "6", "query_text": "10% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.", "negative": "Distant CREs are less conserved among species.", "negatives": ["Distant CREs are less conserved among species.", "BCL-2 activation antagonizes the apoptotic effects of c-Myc.", "Sympathetic nerve activity is elevated throughout normal pregnancy.", "Therapeutics receiving accelerated approval encounter a lower frequency of post-marketing safety events", "1 in 5 million in UK have abnormal PrP positivity.", "Increased flux of microbial products suppresses immune responses.", "Lack of FGF21 in mice increases life expectancy.", "Bariatric surgery leads to negative outcomes in mental health.", "Carriers of HNF4A mutations are at reduced risk for diabetes.", "Vitamin D is an important factor in the relationship between calcium and parathyroid hormone."], "hard_negatives": ["10% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.", "90% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.", "The mean suicide rate in women is lower after miscarriage than live birth.", "The mean suicide rate in women is higher after miscarriage than live birth.", "53% of perinatal mortality is due to low birth weight.", "There was an estimated 30 million cases of pneumonia in young children worldwide in 2010.", "The peak incidence of fractures occurs in toddlers.", "Sepsis related mortality has risen from 2009 to 2014.", "For every 1,000 children with cerebral palsy, more than 300 of them are premature or underweight at birth.", "Incidence of sepsis has fallen substantially from 2009 to 2014."], "hard_negative": "10% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months."}
{"query_id": "9", "query_text": "32% of liver transplantation programs required patients to discontinue methadone treatment in 2001.", "negative": "Activation of the Rac1 homolog CED-10 kills viable cells in SRGP-1 mutant Caenorhabditis elegans.", "negatives": ["Activation of the Rac1 homolog CED-10 kills viable cells in SRGP-1 mutant Caenorhabditis elegans.", "Ribosomal protein (RP) expression is controlled in part by stress-activated regulators.", "Pre-mRNAs associated with spliceosomal components are more stable than unassociated splicing substrates.", "TNFAIP3 is a tumor enhancer in glioblastoma.", "KLF4 is necessary for VSMCs to gain genetic characteristics of other cell types within atherosclerotic lesions.", "Increased microtubule acetylation exacerbates LRRK2 Roc-COR domain mutation induced locomotor deficits.", "Crossover hot spots are found within gene promoters in Saccharomyces cerevisiae.", "Increased flux of microbial products suppresses immune responses.", "Foxk2 regulates autophagy genes in muscle cells and fibroblast cells.", "Pyridostatin prevents double-strand breaks accumulation."], "hard_negatives": ["32% of liver transplantation programs required patients to discontinue methadone treatment in 2001.", "The US health care system can save up to $5 billion if 7% of patients waiting for kidney transplants participate in the optimized national kidney paired donation program.", "CRP is positively correlated with postoperative mortality following Coronary Artery Bypass Graft (CABG) surgery.", "A breast cancer patient's capacity to metabolize tamoxifen influences treatment outcome.", "Pioglitazone use is significantly associated with an increased risk of pancreatic cancer.", "Angiotensin converting enzyme inhibitors are associated with decreased risk for functional renal insufficiency.", "The relationship between a breast cancer patient's capacity to metabolize tamoxifen and treatment outcome is independent of the patient's genetic make-up.", "Risk of cardiovascular events can be cut by a third by using antihypertensive drug therapy among hemodialysis patients.", "Incidence of heart failure increased by 10% in women since 1979.", "61% of colorectal cancer patients are diagnosed with regional or distant metastases."], "hard_negative": "32% of liver transplantation programs required patients to discontinue methadone treatment in 2001."}
{"query_id": "10", "query_text": "4-PBA treatment decreases endoplasmic reticulum stress in response to general endoplasmic reticulum stress markers.", "negative": "Bacteriophagaes MS2 and Q\u03b2 are members of the Leviviridae.", "negatives": ["Bacteriophagaes MS2 and Q\u03b2 are members of the Leviviridae.", "Approximately 250,000 people are infected with human T-cell lymphotropic virus type 1 in the United Kingdom.", "Mice are incapable of producing neutralizing antibodies in reponse to the Chikungunya virus (CHIKV) produced in mosquitos.", "Ly6C hi monocytes have a higher inflammatory capacity than Ly6C lo monocytes.", "Chemical injury represses transglutaminase 2 activity.", "The density of cytokine receptor bearing cells affects the distance over which cytokines act.", "The most prevalent adverse events to Semaglutide are gastrointestinal.", "Misunderstandings between doctors and patients can lead to non-adherence.", "APOE4 expression in iPSC-derived neurons results in decreased tau phosphorylation.", "A single nucleotide variant the gene DGKK is strongly associated with increased risk of hypospadias."], "hard_negatives": ["4-PBA treatment decreases endoplasmic reticulum stress in response to general endoplasmic reticulum stress markers.", "4-PBA treatment raises endoplasmic reticulum stress in response to general endoplasmic reticulum stress markers.", "CHOP is a general endoplasmic reticulum stress marker.", "BiP is a general endoplasmic reticulum stress marker.", "ATF4 is a general endoplasmic reticulum stress marker.", "MafA ubiquitination increases the recruitment of coavtivator P/CAF by MafA.", "MafA ubiquitination decreases the recruitment of coavtivator P/CAF by MafA.", "Emodin forms hydrogen bonds with residues involved in PGAM1 substrate binding.", "Glucose restriction to 0.05% reduces RLS (replicative life span) by 20-40% in S. cerevisiae.", "Ethanol stress increases the expression of IBP in bacteria."], "hard_negative": "4-PBA treatment decreases endoplasmic reticulum stress in response to general endoplasmic reticulum stress markers."}
{"query_id": "11", "query_text": "4-PBA treatment raises endoplasmic reticulum stress in response to general endoplasmic reticulum stress markers.", "negative": "L3MBTL2 binds to H2AK119Ub marked chromatin to form a PRC1 complex.", "negatives": ["L3MBTL2 binds to H2AK119Ub marked chromatin to form a PRC1 complex.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have shorter lifetime exposure to estrogen due to a decreased reproductive period.", "Lamins are found within the inner layer of the mitochondrial membrane of all cells.", "The removal of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells.", "IL-10 production by monocytes inhibits CD4 + T cell response.", "Long chain polyunsaturated fatty acids supplementation has no significant effects on wheezing or asthma at 3 and 6 years.", "F4/80+ macrophages regulate mature osteoblast maintenance.", "B cells go though plasmablast differentiation and antibody production by continuous expression of EBI2.", "Ethanol stress reduces the expression of SRL in bacteria.", "Radioiodine treatment of non-toxic multinodular goitre increases thyroid volume."], "hard_negatives": ["4-PBA treatment decreases endoplasmic reticulum stress in response to general endoplasmic reticulum stress markers.", "4-PBA treatment raises endoplasmic reticulum stress in response to general endoplasmic reticulum stress markers.", "CHOP is a general endoplasmic reticulum stress marker.", "BiP is a general endoplasmic reticulum stress marker.", "ATF4 is a general endoplasmic reticulum stress marker.", "MafA ubiquitination increases the recruitment of coavtivator P/CAF by MafA.", "Emodin forms hydrogen bonds with residues involved in PGAM1 substrate binding.", "MafA ubiquitination decreases the recruitment of coavtivator P/CAF by MafA.", "Ethanol stress increases the expression of IBP in bacteria.", "Glucose restriction to 0.05% reduces RLS (replicative life span) by 20-40% in S. cerevisiae."], "hard_negative": "4-PBA treatment decreases endoplasmic reticulum stress in response to general endoplasmic reticulum stress markers."}
{"query_id": "12", "query_text": "40mg/day dosage of folic acid and 2mg/day dosage of vitamin B12 does not affect chronic kidney disease (CKD) progression.", "negative": "Distant CREs are important for transcriptional regulation.", "negatives": ["Distant CREs are important for transcriptional regulation.", "Insulin effects appetite via ventral tegmental neurons.", "Depletion of nitric oxide is responsible for vasospasm.", "ART has no effect on the infectiveness of HIV-positive people.", "CRP is positively correlated with postoperative mortality following Coronary Artery Bypass Graft (CABG) surgery.", "Risk-adjusted mortality rates are similar in teaching and non-teaching hospitals.", "Bariatric surgery increases rates of colorectal cancer.", "Patients in stable partnerships progress from HIV to death at the same rate as patients not in partnerships.", "Deletion of ATM and Rad3 related protein is not predictive of acute tissue loss.", "Exhaustion of B cells contributes to poor Ab response in HIV-infected individuals."], "hard_negatives": ["40mg/day dosage of folic acid and 2mg/day dosage of vitamin B12 does not affect chronic kidney disease (CKD) progression.", "Angiotensin converting enzyme inhibitors are associated with decreased risk for functional renal insufficiency.", "A deficiency of vitamin B12 decreases blood levels of homocysteine.", "A deficiency of folate increases blood levels of homocysteine.", "Insulin decreases risk of severe kidney failure.", "Vitamin D deficiency effects birth weight.", "Vitamin D is an important factor in the relationship between calcium and parathyroid hormone.", "The US health care system can save up to $5 billion if 7% of patients waiting for kidney transplants participate in the optimized national kidney paired donation program.", "A deficiency of vitamin B6 decreases blood levels of homocysteine.", "Ten percent (10%) of kidney cancers in the UK are attributable to excess weight."], "hard_negative": "40mg/day dosage of folic acid and 2mg/day dosage of vitamin B12 does not affect chronic kidney disease (CKD) progression."}
{"query_id": "14", "query_text": "5'-nucleotidase metabolizes 6MP.", "negative": "Patients with common epithelial cancers  are more likely to have an emergency event as their first hospital admission if they live in resource-deprived areas.", "negatives": ["Patients with common epithelial cancers  are more likely to have an emergency event as their first hospital admission if they live in resource-deprived areas.", "Increased flux of microbial products provokes immune responses.", "Helminths interfere with immune system control of coinfections by microbial pathogens 16.", "Homozygous deletion of murine Sbds gene from osterix-expressing mesenchymal stem and progenitor cells (MPCs) induces oxidative stress.", "Replacement of OCT4 and SOX2 genes with GATA3 has the ability to reprogram human cells.", "Rhythmic expression of Cry1 translates directly into a circadian regulation of cAMP signaling in hepatic glucose metabolism.", "Chinese individuals with TT homozygosity in the MTHFR gene are more vulnerable to strokes caused by low levels of folate intake.", "Cis-acting lncRNAs control the expression of genes that are positioned in the vicinity of their transcription sites.", "The DESMOND program demonstrates no significant impact on biochemical outcomes.", "Understanding epigenetic regulation of replication is essential for the reational design of episomally replicating vectors."], "hard_negatives": ["5'-nucleotidase metabolizes 6MP.", "Guanine nucleotide dissociation inhibitor (Rho-GDI) interacts with the p75 NTR death domain", "Ribosome-inactivating protein-2 (RIP-2) interacts with the p75 NTR death domain", "Formation of N-terminal pyroglutamate by glutamine cyclase (GC) competes with NTAQ1 for Nt-Gln substrates.", "The PPR MDA5 has twenty N-terminal CARD domains.", "C2 works synergistically with A-769662 to activate dephosphorylated AMPK.", "p75 NTR - associated cell death executor (NADE) interacts with the p75 NTR death domain", "B3-Galectin decreases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR.", "B3-Galectin increases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR.", "Removal of H3K9me3 by ectopic expression of other H3K9 demethylases improves reprogramming efficiency in SCNT experiments."], "hard_negative": "5'-nucleotidase metabolizes 6MP."}
{"query_id": "15", "query_text": "50% of patients exposed to radiation have activated markers of mesenchymal stem cells.", "negative": "The minor G allele of FOXO3 up-regulates IL-10.", "negatives": ["The minor G allele of FOXO3 up-regulates IL-10.", "PD-1 triggering on monocytes enhances IL-10 production by monocytes.", "In British Men, haplogroup I decreases risk of cardiovascular disease.", "Lysine histone demethylase inhibitor JIB 04 is inactive against KDM5A.", "Removal of H3K9me3 by ectopic expression of other H3K9 demethylases improves reprogramming efficiency in SCNT experiments.", "Rising temperatures caused by global warming lowers the risk of dengue fever transmission.", "C2 works synergistically with A-769662 to activate dephosphorylated AMPK.", "Algerian physicians constitue the largest component of sub-Saharan Africa-trained physicians in the United States.", "Genetic deletion of JAM-A increases gut permeability.", "Citrullinated proteins externalized in neutrophil extracellular traps act indirectly to disrupt the inflammatory cycle."], "hard_negatives": ["50% of patients exposed to radiation have activated markers of mesenchymal stem cells.", "Less than 10% of patients exposed to radiation have activated markers of mesenchymal stem cells.", "At least 85% of patients exposed to radiation have activated markers of myofibroblasts.", "1-1% of colorectal cancer patients are diagnosed with regional or distant metastases.", "61% of colorectal cancer patients are diagnosed with regional or distant metastases.", "Cancer-associated fibroblasts (CAFs) have no known interaction with cancer cells in the formation and activation of CAFs.", "Many cytokines that are produced by cancer cells also contribute to carcinogenesis.", "Cancer-associated fibroblasts (CAFs) interact with cancer cells to mediate formation and activation of CAFs.", "TMEM27 is a marker for beta cells.", "In pediatric tissue, most T cells are naive T cell emigrants from the thymus."], "hard_negative": "50% of patients exposed to radiation have activated markers of mesenchymal stem cells."}
{"query_id": "17", "query_text": "53% of perinatal mortality is due to low birth weight.", "negative": "Nuclear transfer from adult human fibroblasts to human oocytes can give rise to blastocysts containing expandable pluripotent cells.", "negatives": ["Nuclear transfer from adult human fibroblasts to human oocytes can give rise to blastocysts containing expandable pluripotent cells.", "Stiff substrates encourage mesodermal differentiation by degrading beta-catenin in an integrin-dependent manner.", "90% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.", "Cellular clocks are not predictive of mitosis timing in NIH 3T3 cells.", "Physical injury represses transgultaminase activity.", "Increased mobility of retrotransposons does not lead to mutation and higher tumorigenesis rates.", "Ultrasound guidance significantly reduces the number of traumatic procedures when attempting needle insertion.", "MUC1-C activates the NF-\u03baB p65 signaling pathway by interacting with I\u03baB kinase \u00df.", "Formation of N-terminal pyroglutamate by glutamine cyclase (GC) competes with NTAQ1 for Nt-Gln substrates.", "The minor G allele of FOXO3 is related to less severe symptoms of Crohn's Disease."], "hard_negatives": ["53% of perinatal mortality is due to low birth weight.", "The mean suicide rate in women is lower after miscarriage than live birth.", "The mean suicide rate in women is higher after miscarriage than live birth.", "Birth-weight is negatively associated with breast cancer.", "10% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.", "90% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.", "Women with a lower birth weight are more likely to develop breast cancer later in life.", "For every 1,000 children with cerebral palsy, more than 300 of them are premature or underweight at birth.", "The risk of breast cancer among parous women decreases with placental weight of pregnancies.", "Excess gestational weight gain is associated with obesity-related pregnancy outcomes."], "hard_negative": "53% of perinatal mortality is due to low birth weight."}
{"query_id": "18", "query_text": "61% of colorectal cancer patients are diagnosed with regional or distant metastases.", "negative": "Adult tissue-resident macrophages are seeded before birth.", "negatives": ["Adult tissue-resident macrophages are seeded before birth.", "Dscam1 acts as a hypervariable pattern-recognition receptor for the immune system.", "Walking in traffic areas in London did not improve lung function in elderly adults.", "Folate and vitamin B12 levels influence the association between homocysteine and preeclampsia.", "Surfactin producing cells and exopolymer producing cells cooperate to generate \"Van Gogh\" bundles that have sliding abilities on specialized media.", "Pyridostatin induces double-strand breaks accumulation.", "The composition of myosin-II isoform switches from the A isoform to the B isoform during hematopoietic differentiation.", "GATA3 regulates self-renewal capacity in bone marrow hematopoietic stem cells.", "Scapular stabilizer exercises are more effective than general exercise therapy in reducing pain and improving function of the shoulder.", "Primary cervical cytology screening with HPV detection has higher longitudinal sensitivity to detect severe cervical intraepithelial neoplasia than conventional cytology."], "hard_negatives": ["61% of colorectal cancer patients are diagnosed with regional or distant metastases.", "1-1% of colorectal cancer patients are diagnosed with regional or distant metastases.", "Ten percent (10%) of kidney cancers in the UK are attributable to excess weight.", "Bariatric surgery reduces colorectal cancer.", "Bariatric surgery increases rates of colorectal cancer.", "Metastatic colorectal cancer treated with a single agent fluoropyrimidines resulted in similar efficacy and better quality of life when compared with oxaliplatin-based chemotherapy in elderly patients.", "Cancer-associated fibroblasts (CAFs) have no known interaction with cancer cells in the formation and activation of CAFs.", "At least 85% of patients exposed to radiation have activated markers of myofibroblasts.", "Cancer-associated fibroblasts (CAFs) interact with cancer cells to mediate formation and activation of CAFs.", "ALDH1 expression is associated with poorer prognosis for breast cancer primary tumors."], "hard_negative": "61% of colorectal cancer patients are diagnosed with regional or distant metastases."}
{"query_id": "19", "query_text": "7-day-old adult Caenorhabditis elegans exhibit approximately 5% of the learning capacity seen in 1-day old adults.", "negative": "B cells go though plasmablast differentiation and antibody production by continuous expression of EBI2.", "negatives": ["B cells go though plasmablast differentiation and antibody production by continuous expression of EBI2.", "Converting apoE4 to apoE3 by gene editing prevents the pathology associated with apoE4 in human iPSCderived neurons.", "The World Health Organization's (WHO) data collection process is biased downward by unequal selection of larger outbreaks.", "COPI coatmer is involved in viral replication.", "cSMAC formation represses weak ligand signalling.", "HSCT-T dosage may not be diagnostic if the onset of symptoms occurs less than 3 hours before AMI.", "Bcp1 is a chaperone for Rpl23.", "PTEN is a regulator for the transcriptional activity of SRF", "Cytosolic proteins bind to iron-responsive elements on mRNAs coding for TFRC1.", "Long - range chromatin interactions regulate transcription."], "hard_negatives": ["7-day-old adult Caenorhabditis elegans exhibit approximately 75% of the learning capacity seen in 1-day old adults.", "7-day-old adult Caenorhabditis elegans exhibit approximately 5% of the learning capacity seen in 1-day old adults.", "Individuals with Alzheimers who participate in six months of physical activity improve cognitive function for up to 18 months.", "Asymptomatic visual impairment screening in elderly populations leads to improved vision.", "The peak incidence of fractures occurs during pubertal growth spurt in early adolescents.", "For every 1,000 children with cerebral palsy, more than 300 of them are premature or underweight at birth.", "Adult tissue-resident macrophages possess a self-renewing capacity.", "The proliferative capacity of neural progenitors differs across species.", "Hypothalamic glutamate neurotransmission is unrelated to energy balance.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have increased risk for Alzheimer's disease."], "hard_negative": "7-day-old adult Caenorhabditis elegans exhibit approximately 75% of the learning capacity seen in 1-day old adults."}
{"query_id": "20", "query_text": "7-day-old adult Caenorhabditis elegans exhibit approximately 75% of the learning capacity seen in 1-day old adults.", "negative": "Pioglitazone use is not associated with an increased risk of prostate cancer.", "negatives": ["Pioglitazone use is not associated with an increased risk of prostate cancer.", "Autophagy deficiency in the liver increases vulnerability to insulin resistance.", "F4/80+ macrophages regulate mature osteoblast maintenance.", "Post-transcriptional handling of mitochondrial transcripts occurs in mitochondrial RNA granules.", "Gpr124 suppresses BBB breakdown in mouse models of ischemic stroke.", "Trans-acting factors, such as lncRNAs, influence mRNA translation.", "Individuals with low serum vitamin D concentrations have decreased risk of multiple sclerosis.", "Glycan adaptation is rarely observed in the B-cell repertoire.", "The generation of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells.", "C2 works synergistically with A-769662 to activate dephosphorylated AMPK."], "hard_negatives": ["7-day-old adult Caenorhabditis elegans exhibit approximately 75% of the learning capacity seen in 1-day old adults.", "7-day-old adult Caenorhabditis elegans exhibit approximately 5% of the learning capacity seen in 1-day old adults.", "Individuals with Alzheimers who participate in six months of physical activity improve cognitive function for up to 18 months.", "Asymptomatic visual impairment screening in elderly populations leads to improved vision.", "The peak incidence of fractures occurs during pubertal growth spurt in early adolescents.", "For every 1,000 children with cerebral palsy, more than 300 of them are premature or underweight at birth.", "Adult tissue-resident macrophages possess a self-renewing capacity.", "Hypothalamic glutamate neurotransmission is unrelated to energy balance.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have increased risk for Alzheimer's disease.", "Headaches are correlated with cognitive impairment."], "hard_negative": "7-day-old adult Caenorhabditis elegans exhibit approximately 75% of the learning capacity seen in 1-day old adults."}
{"query_id": "21", "query_text": "70% of burn patients are admitted for hospitalization and further treatment after appearing at hospital emergency wards or outpatient clinics.", "negative": "Pseudoknots are not evolutionarily conserved in most eukaryotes.", "negatives": ["Pseudoknots are not evolutionarily conserved in most eukaryotes.", "Rotator cuff exercises are more effective than general exercise therapy in reducing pain and improving function of the shoulder.", "Pseudoknots are not evolutionarily conserved in most eukaryotes.", "Angiotensin converting enzyme inhibitors are associated with decreased risk for functional renal insufficiency.", "90% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.", "The deregulated and prolonged activation of monocytes improves inflammatory disease outcomes.", "53% of perinatal mortality is due to low birth weight.", "In patients with congenital heart defects, \u03b2-blockers significantly improve clinical heart failure outcomes.", "Rapamycin increases the concentration of triacylglycerols in fruit flies.", "TRAP+ osteoclasts regulate mature osteoblast maintenance."], "hard_negatives": ["70% of burn patients are admitted for hospitalization and further treatment after appearing at hospital emergency wards or outpatient clinics.", "Patients with common epithelial cancers are less likely to have an emergency event as their first hospital admission if they live in resource-deprived areas.", "Patients with common epithelial cancers  are more likely to have an emergency event as their first hospital admission if they live in resource-deprived areas.", "Incidence of sepsis has fallen substantially from 2009 to 2014.", "Sepsis related mortality has risen from 2009 to 2014.", "One in five surgical randomized controlled trials are discontinued early.", "Tuberculosis incidence occurs at higher rates in more sparsely populated areas in the UK.", "One in two surgical randomized controlled trials are discontinued early.", "High levels of CRP lead to a higher risk of exacerbations in chronic obstructive pulmonary disease (COPD).", "Risk-adjusted mortality rates are similar in teaching and non-teaching hospitals."], "hard_negative": "70% of burn patients are admitted for hospitalization and further treatment after appearing at hospital emergency wards or outpatient clinics."}
{"query_id": "22", "query_text": "76-85% of people with severe mental disorder receive no treatment in low and middle income countries.", "negative": "The NF-\u03baB essential modulator gene induces intestinal inflammation by promoting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death.", "negatives": ["The NF-\u03baB essential modulator gene induces intestinal inflammation by promoting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death.", "Hypocretin neurones suppress panicprone state in rats.", "V-9302 inhibits antitumor responses by decreasing cell death and oxidative stress.", "Autologous transplantation of mesenchymal stem cells has better graft function than induction therapy with anti-interleukin-2 receptor antibodies.", "Cnn1 recruitment varies with cell cycle timing.", "Cardiac tissue-resident macrophages directly contribute to electrical activity.", "In melanoma, anti-CTLA-4 treatment reinvigorates exhausted PD-1+Eomes+CD8 T cells.", "Stiff substrates inhibit mesodermal differentiation by degrading beta-catenin in an integrin-dependent manner.", "N348I mutations cause resistance to nevirapine.", "Eliminating the last sporadic cases of malaria requires considerable funding."], "hard_negatives": ["76-85% of people with severe mental disorder receive no treatment in low and middle income countries.", "The proportion of people with visual difficulty is two times higher in low-income countries than in high-income countries.", "The mean suicide rate in women is higher after miscarriage than live birth.", "The mean suicide rate in women is lower after miscarriage than live birth.", "90% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.", "10% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.", "53% of perinatal mortality is due to low birth weight.", "Sepsis related mortality has risen from 2009 to 2014.", "Epidemiological disease burden from noncommunicable diseases is more prevalent in high economic settings.", "Input from  mental and physical health care professionals is not effective at decreasing homelessness."], "hard_negative": "76-85% of people with severe mental disorder receive no treatment in low and middle income countries."}
{"query_id": "24", "query_text": "90% of patients with melanoma and an objective response to PD-1 blockade will experience a progression in their melanoma.", "negative": "Cognitive behavioral therapy is an ineffective treatment for insomnia", "negatives": ["Cognitive behavioral therapy is an ineffective treatment for insomnia", "Sequence conservation in gene regulatory regions between species is a high-accuracy predictor of conserved functionality.", "Urbanization is an important risk factor related to the transmission of dengue fever.", "Pre-mRNAs associated with spliceosomal components are more stable than unassociated splicing substrates.", "Tirasemtiv has no effect on cardiac muscle.", "Treatment with a protein named FN impairs regenerative abilities of aged muscles.", "Dexamethasone increases risk of postoperative bleeding.", "Formation of N-terminal pyroglutamate by glutamine cyclase (GC) competes with NTAQ1 for Nt-Gln substrates.", "RANK-RANKL pathway signalling has no known association with development of Aire-expressing medullary thymic epithelial cells.", "Vitamin D is an important factor in the relationship between calcium and parathyroid hormone."], "hard_negatives": ["90% of patients with melanoma and an objective response to PD-1 blockade will experience a progression in their melanoma.", "In melanoma, anti-CTLA-4 treatment reinvigorates exhausted PD-1+Eomes+CD8 T cells.", "Side effects associated with antidepressants increases risk of stroke.", "The most prevalent adverse events to Semaglutide are cardiovascular.", "In patients with congenital heart defects, \u03b2-blockers significantly improve clinical heart failure outcomes.", "A breast cancer patient's capacity to metabolize tamoxifen influences treatment outcome.", "Incidence of 10/66 dementia is lower than the incidence of DSM-IV dementia.", "Incidence of 10/66 dementia is higher than the incidence of DSM-IV dementia.", "The relationship between a breast cancer patient's capacity to metabolize tamoxifen and treatment outcome is independent of the patient's genetic make-up.", "PD-1 triggering on monocytes enhances IL-10 production by monocytes."], "hard_negative": "90% of patients with melanoma and an objective response to PD-1 blockade will experience a progression in their melanoma."}
{"query_id": "25", "query_text": "90% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.", "negative": "Cost effectiveness evaluations based on cRCT data accurately reflect prices for patients in actual clinical practice.", "negatives": ["Cost effectiveness evaluations based on cRCT data accurately reflect prices for patients in actual clinical practice.", "CD44v6 is not associated with constitutive and reprogrammed cancer stem cells driving cancer metastasis.", "The deamination of cytidine to uridine on the minus strand of viral DNA can inactivate the viral genome by inducing G-to-A mutations.", "CDK6 shows impaired binding to loss-of-function variants of p18 INK4C.", "Distant CREs are important for transcriptional regulation.", "Chinese individuals with TT homozygosity in the MTHFR gene are less vulnerable to strokes caused by low levels of folate intake.", "Long chain polyunsaturated fatty acids supplementation is associated with lower rates of atopic eczema at 1 year.", "Expression of oncolytic virus antigens as peptides makes relapse more likely.", "Cancer-associated fibroblasts (CAFs) have no known interaction with cancer cells in the formation and activation of CAFs.", "Asymptomatic visual impairment screening in elderly populations leads to improved vision."], "hard_negatives": ["90% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.", "10% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.", "The mean suicide rate in women is lower after miscarriage than live birth.", "The mean suicide rate in women is higher after miscarriage than live birth.", "53% of perinatal mortality is due to low birth weight.", "There was an estimated 30 million cases of pneumonia in young children worldwide in 2010.", "The peak incidence of fractures occurs in toddlers.", "Sepsis related mortality has risen from 2009 to 2014.", "For every 1,000 children with cerebral palsy, more than 300 of them are premature or underweight at birth.", "Incidence of sepsis has fallen substantially from 2009 to 2014."], "hard_negative": "90% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months."}
{"query_id": "26", "query_text": "A 100g dose of chloroquine chemoprophylactic regimen results in retinal toxicity after 1 year of weekly intake.", "negative": "Smc5/6 engagment halts the activation of SUMO E3 ligase Mms21 by ATP-dependent remolding.", "negatives": ["Smc5/6 engagment halts the activation of SUMO E3 ligase Mms21 by ATP-dependent remolding.", "Glial calcium waves influence seizures.", "Chenodeoxycholic acid treatment decreases brown adipose tissue activity.", "Post-transcriptional handling of mitochondrial transcripts occurs in mitochondrial RNA granules.", "The deregulated and prolonged activation of monocytes has deleterious effects in chronic infectious conditions.", "Exercise reduces cancer mortality rates among Chinese citizens.", "Induced hepatic stem cells possess the potential to differentiate into hepatocytic cells.", "Increased conversion of PGE 2 to PPARy ligand 15-ket-PGE 2 causes accumulation of PGE.", "4-PBA treatment raises endoplasmic reticulum stress in response to general endoplasmic reticulum stress markers.", "Reduced responsiveness to interleukin-2 in regulatory T cells is associated with autoimmune diseases such as Type 1 Diabetes."], "hard_negatives": ["A 100g dose of chloroquine chemoprophylactic regimen results in retinal toxicity after 1 year of weekly intake.", "A 100g dose of chloroquine chemoprophylactic regimen results in retinal toxicity after 5-6 years of weekly intake.", "Varenicline monotherapy is more effective after 26 weeks of treatment compared to combination nicotine replacement therapies with varenicline or bupropion.", "The most prevalent adverse events to Semaglutide are gastrointestinal.", "Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission.", "The most prevalent adverse events to Semaglutide are cardiovascular.", "Combination nicotine replacement therapies with varenicline or bupropion are more effective after 12 weeks of reatment compared to varenicline monotherapy.", "There is no increased risk of hypospadias with clomiphene.", "Sildenafil worsens erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.", "Metastatic colorectal cancer treated with a single agent fluoropyrimidines resulted in similar efficacy and better quality of life when compared with oxaliplatin-based chemotherapy in elderly patients."], "hard_negative": "A 100g dose of chloroquine chemoprophylactic regimen results in retinal toxicity after 1 year of weekly intake."}
{"query_id": "27", "query_text": "A 100g dose of chloroquine chemoprophylactic regimen results in retinal toxicity after 5-6 years of weekly intake.", "negative": "YAP/TAZ is required in intestinal regeneration in mouse models of ulcerative colitis.", "negatives": ["YAP/TAZ is required in intestinal regeneration in mouse models of ulcerative colitis.", "Adult tissue-resident macrophages possess a self-renewing capacity.", "The US health care system can save up to $5 billion if 7% of patients waiting for kidney transplants participate in the optimized national kidney paired donation program.", "LRBA promotes CTLA - 4 recycling.", "Cognitive behavioral therapy is an ineffective treatment for insomnia", "Headaches are correlated with cognitive impairment.", "The peak incidence of fractures occurs in toddlers.", "In British Men, haplogroup I increases risk of cardiovascular disease by 50%.", "The generation of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells.", "Diminished ovarian reserve is a reliable indicator of infertility in a non-infertile population."], "hard_negatives": ["A 100g dose of chloroquine chemoprophylactic regimen results in retinal toxicity after 5-6 years of weekly intake.", "A 100g dose of chloroquine chemoprophylactic regimen results in retinal toxicity after 1 year of weekly intake.", "Varenicline monotherapy is more effective after 26 weeks of treatment compared to combination nicotine replacement therapies with varenicline or bupropion.", "Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission.", "The most prevalent adverse events to Semaglutide are cardiovascular.", "The most prevalent adverse events to Semaglutide are gastrointestinal.", "There is no increased risk of hypospadias with clomiphene.", "Combination nicotine replacement therapies with varenicline or bupropion are more effective after 12 weeks of reatment compared to varenicline monotherapy.", "Antiretroviral therapy increases rates of tuberculosis across a broad range of CD4 strata.", "Metastatic colorectal cancer treated with a single agent fluoropyrimidines resulted in similar efficacy and better quality of life when compared with oxaliplatin-based chemotherapy in elderly patients."], "hard_negative": "A 100g dose of chloroquine chemoprophylactic regimen results in retinal toxicity after 5-6 years of weekly intake."}
{"query_id": "28", "query_text": "A T helper 2 cell (Th2) environment impedes disease development in patients with systemic lupus erythematosus (SLE).", "negative": "Including pharmacists in rounding teams reduces the incidence of adverse drug events (ADEs).", "negatives": ["Including pharmacists in rounding teams reduces the incidence of adverse drug events (ADEs).", "Ethanol stress lowers the expression of PSP in bacteria.", "Gpr124 suppresses BBB breakdown in mouse models of ischemic stroke.", "BLM gene encodes RecQ-class DNA helicase.", "Active Ly49Q prevents neutrophil polarization.", "The peak incidence of fractures occurs in toddlers.", "miRNAs regulate a unique suite of mRNAs to maintain homeostasis in cells.", "Environmental factors can influence the development of breast cancer.", "DUSP4 downregulation deactivates the Ras-ERK pathway", "Cancers that initially benefit from epidermal growth factor receptor targeted therapies later become refractory through several mechanisms."], "hard_negatives": ["A T helper 2 cell (Th2) environment impedes disease development in patients with systemic lupus erythematosus (SLE).", "Basophils promote disease development in patients with systemic lupus erythematosus (SLE).", "Type 1 Diabetes is associated with subtle perturbations in T reg development.", "Reduced responsiveness to interleukin-2 in regulatory T cells is associated with autoimmune diseases such as Type 1 Diabetes.", "Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection decreases dissemination of Salmonella Typhimurium from the gut.", "Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection increases dissemination of Salmonella Typhimurium from the gut.", "Approximately 250,000 people are infected with human T-cell lymphotropic virus type 1 in the United Kingdom.", "Lice attenuated SIV vaccines induce a stronger antigen-specific T cell response in lymph node cells.", "EG7 tumors can be killed by systemic oxaliplatin primed CD8+ T cells from the tumor-draining lymph node cells.", "In pediatric tissue, most T cells are naive T cell emigrants from the thymus."], "hard_negative": "A T helper 2 cell (Th2) environment impedes disease development in patients with systemic lupus erythematosus (SLE)."}
{"query_id": "30", "query_text": "A breast cancer patient's capacity to metabolize tamoxifen influences treatment outcome.", "negative": "A deficiency of vitamin B6 decreases blood levels of homocysteine.", "negatives": ["A deficiency of vitamin B6 decreases blood levels of homocysteine.", "Inside the body, falciparum parasites reproduce asexually.", "Chlamydia trachomatis is most prevalent in the UK among individuals in their 50s and 60s.", "Treatment with the EC uptake inhibitor AM404 resulted in a dose-dependent decrease in the expression of immobility.", "Individuals with low serum vitamin D concentrations have decreased risk of multiple sclerosis.", "Transcription rates in S. cerevisiae range between 7 and 12 kb/min.", "TNFAIP3 is a tumor enhancer in glioblastoma.", "eRNAs influence is linked to senescence, aging, and carcinogenesis.", "Reduced phosphorylation of PP2A suppresses HDAC4 dephosphorylation.", "Cellular clocks are not predictive of mitosis timing in NIH 3T3 cells."], "hard_negatives": ["A breast cancer patient's capacity to metabolize tamoxifen influences treatment outcome.", "The relationship between a breast cancer patient's capacity to metabolize tamoxifen and treatment outcome is independent of the patient's genetic make-up.", "Sildenafil worsens erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.", "Side effects associated with antidepressants do not represent a mortality risk to postmenopausal women.", "Pioglitazone use is significantly associated with an increased risk of pancreatic cancer.", "Pioglitazone use is significantly associated with an increased risk of prostate cancer.", "Pioglitazone use is not associated with an increased risk of prostate cancer.", "Side effects associated with antidepressants increases risk of stroke.", "The most prevalent adverse events to Semaglutide are cardiovascular.", "Side effects associated with antidepressants lower risk of myocardial infarction."], "hard_negative": "A breast cancer patient's capacity to metabolize tamoxifen influences treatment outcome."}
{"query_id": "32", "query_text": "A country's Vaccine Alliance (GAVI) eligibility is not indictivate of accelerated adoption of the Hub vaccine.", "negative": "There is no known interaction between Pioneer factor OCT3/4 and major chromatin remodeling factors.", "negatives": ["There is no known interaction between Pioneer factor OCT3/4 and major chromatin remodeling factors.", "Approximately 250,000 people are infected with human T-cell lymphotropic virus type 1 in the United Kingdom.", "Pre-mRNAs associated with spliceosomal components are more stable than unassociated splicing substrates.", "Incidence of sepsis has fallen substantially from 2009 to 2014.", "eRNAs influence is linked to senescence, aging, and carcinogenesis.", "Rapamycin increases the concentration of triacylglycerols in fruit flies.", "There is no relation between Erythromycin use and hypertrophic pyloric stenosis.", "IL-10 production by monocytes inhibits CD4 + T cell response.", "BRCA 1 mutation carriers' risk of breast and ovarian cancer depends on where the mutation is located.", "Adult tissue-resident macrophages are seeded before birth."], "hard_negatives": ["A country's Vaccine Alliance (GAVI) eligibility is not indictivate of accelerated adoption of the Hub vaccine.", "Patients in stable partnerships progress from HIV to death at the same rate as patients not in partnerships.", "The World Health Organization's (WHO) data collection process is biased downward by unequal selection of larger outbreaks.", "Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission.", "Eilat virus (EILV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in nonhuman primates.", "Nonhuman primates are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.", "Therapeutics receiving accelerated approval encounter a lower frequency of post-marketing safety events", "Rising temperatures caused by global warming lowers the risk of dengue fever transmission.", "Exhaustion of B cells contributes to poor Ab response in HIV-infected individuals.", "Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 encourage West Nile virus replication in cortical neurons."], "hard_negative": "A country's Vaccine Alliance (GAVI) eligibility is not indictivate of accelerated adoption of the Hub vaccine."}
{"query_id": "34", "query_text": "A deficiency of folate increases blood levels of homocysteine.", "negative": "Piezo1 channels are sensors for cell migration in epithelial cells.", "negatives": ["Piezo1 channels are sensors for cell migration in epithelial cells.", "Folate and vitamin B12 levels influence the association between homocysteine and preeclampsia.", "Fibroblast growth factor 21 protects against atherosclerosis by modulating adiponectin and SREBP2 levels.", "The NF-\u03baB essential modulator gene prevents intestinal inflammation by inhibiting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death.", "\u03b2-sheet opening occurs during pleurotolysin pore formation.", "BCL-2 activation antagonizes the apoptotic effects of c-Myc.", "Tonic signaling from the scFv induces constitutive stimulation.", "Chlamydia trachomatis is most prevalent in the UK among individuals in their 50s and 60s.", "ART has no effect on the infectiveness of HIV-positive people.", "Tirasemtiv targets fast-twitch muscle."], "hard_negatives": ["A deficiency of folate increases blood levels of homocysteine.", "A deficiency of vitamin B12 decreases blood levels of homocysteine.", "A deficiency of vitamin B6 decreases blood levels of homocysteine.", "Intake of folic acid (FA) and vitamin B6 (VB6) reduces levels of homocysteine.", "Intake of folic acid (FA) and vitamin B6 (VB6) increases levels of homocysteine.", "Folate and vitamin B12 levels influence the association between homocysteine and preeclampsia.", "Vitamin D is an important factor in the relationship between calcium and parathyroid hormone.", "Autophagy deficiency in the liver increases vulnerability to insulin resistance.", "LDL cholesterol has a causal role in the development of cardiovascular disease.", "40mg/day dosage of folic acid and 2mg/day dosage of vitamin B12 does not affect chronic kidney disease (CKD) progression."], "hard_negative": "A deficiency of folate increases blood levels of homocysteine."}
{"query_id": "35", "query_text": "A deficiency of vitamin B12 decreases blood levels of homocysteine.", "negative": "The G34R/V mutation creates a hypomethylated phenotype at the H3K36 histone.", "negatives": ["The G34R/V mutation creates a hypomethylated phenotype at the H3K36 histone.", "miR-142-5P is a known regulator of raised body temperature.", "Homozygous deletion of murine Sbds gene from osterix-expressing mesenchymal stem and progenitor cells (MPCs) induces oxidative stress.", "The predominant localization of Linc00173 is in mononuclear macrophage nuclei.", "Pre-mRNAs associated with spliceosomal components are more stable than unassociated splicing substrates.", "Surgical treatment is not superior to non-surgical in treating adults with displaced fractures of the proximal humerus.", "90% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.", "Antidepressants reduce the severity of migraines.", "TNFAIP3 is a tumor enhancer in glioblastoma.", "Antimicrobial agents are more effective due to the pressure of antimicrobial usage."], "hard_negatives": ["A deficiency of vitamin B12 decreases blood levels of homocysteine.", "A deficiency of vitamin B6 decreases blood levels of homocysteine.", "A deficiency of folate increases blood levels of homocysteine.", "Vitamin D is an important factor in the relationship between calcium and parathyroid hormone.", "Intake of folic acid (FA) and vitamin B6 (VB6) reduces levels of homocysteine.", "Intake of folic acid (FA) and vitamin B6 (VB6) increases levels of homocysteine.", "Vitamin D deficiency effects birth weight.", "Folate and vitamin B12 levels influence the association between homocysteine and preeclampsia.", "40mg/day dosage of folic acid and 2mg/day dosage of vitamin B12 does not affect chronic kidney disease (CKD) progression.", "Carriers of HNF4A mutations are at reduced risk for diabetes."], "hard_negative": "A deficiency of vitamin B12 decreases blood levels of homocysteine."}
{"query_id": "37", "query_text": "A deficiency of vitamin B6 decreases blood levels of homocysteine.", "negative": "Increased flux of microbial products provokes immune responses.", "negatives": ["Increased flux of microbial products provokes immune responses.", "Deletion of ATM and Rad3 related protein leads to acute tissue loss.", "Patients with microcytosis and higher erythrocyte count were more resistant to severe malarial anaemia when infected with Plasmodium falciparum.", "KLF4 is necessary for VSMCs to gain genetic characteristics of other cell types within atherosclerotic lesions.", "Kir7.1 modulates channel activity by the G protein-coupled melanocortin-4 receptor (MC4R) in the paraventricular nucleus of the hypothalamus.", "Omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegetarians.", "Incidence of 10/66 dementia is lower than the incidence of DSM-IV dementia.", "Increased vessel density along with a reduction in fibrosis improves the efficacy of chemotherapy treatments.", "Progerin induces premature aging in stem cells.", "The composition of myosin-II isoform switches from the A isoform to the B isoform during hematopoietic differentiation."], "hard_negatives": ["A deficiency of vitamin B6 decreases blood levels of homocysteine.", "A deficiency of vitamin B12 decreases blood levels of homocysteine.", "A deficiency of folate increases blood levels of homocysteine.", "Intake of folic acid (FA) and vitamin B6 (VB6) increases levels of homocysteine.", "Intake of folic acid (FA) and vitamin B6 (VB6) reduces levels of homocysteine.", "Vitamin D is an important factor in the relationship between calcium and parathyroid hormone.", "Folate and vitamin B12 levels influence the association between homocysteine and preeclampsia.", "Carriers of HNF4A mutations are at reduced risk for diabetes.", "Vitamin D deficiency effects birth weight.", "40mg/day dosage of folic acid and 2mg/day dosage of vitamin B12 does not affect chronic kidney disease (CKD) progression."], "hard_negative": "A deficiency of vitamin B6 decreases blood levels of homocysteine."}
{"query_id": "39", "query_text": "A diminished ovarian reserve does not solely indicate infertility in an a priori non-infertile population.", "negative": "V-9302 inhibits antitumor responses by decreasing cell death and oxidative stress.", "negatives": ["V-9302 inhibits antitumor responses by decreasing cell death and oxidative stress.", "Taxation of sugar-sweetened beverages reduced the incidence rate of type II diabetes in India.", "Vitamin D is an important factor in the relationship between calcium and parathyroid hormone.", "Increased microtubule acetylation repairs interference of axonal transport caused by LRRK2 Roc-COR domain mutations.", "Lack of FGF21 in mice increases life expectancy.", "Autophagy deficiency in the liver increases vulnerability to insulin resistance.", "7-day-old adult Caenorhabditis elegans exhibit approximately 75% of the learning capacity seen in 1-day old adults.", "Beta-band coherence is enhanced for visible stimuli over invisible stimuli.", "Monoclonal antibody targeting of N-cadherin encourages castration resistance.", "Natriuretic peptides protect against diabetes."], "hard_negatives": ["A diminished ovarian reserve does not solely indicate infertility in an a priori non-infertile population.", "A diminished ovarian reserve is a very strong indicator of infertility, even in an a priori non-infertile population.", "Diminished ovarian reserve is a reliable indicator of infertility in a non-infertile population.", "The mean suicide rate in women is lower after miscarriage than live birth.", "The mean suicide rate in women is higher after miscarriage than live birth.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have shorter lifetime exposure to estrogen due to a decreased reproductive period.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have longer lifetime exposure to estrogen due to an increased reproductive period.", "The risk of breast cancer among parous women decreases with placental weight of pregnancies.", "The number of unfertilized oocytes in mated hermaphrodites increases with age.", "Women with a lower birth weight are more likely to develop breast cancer later in life."], "hard_negative": "A diminished ovarian reserve does not solely indicate infertility in an a priori non-infertile population."}
{"query_id": "40", "query_text": "A diminished ovarian reserve is a very strong indicator of infertility, even in an a priori non-infertile population.", "negative": "Students who perform poorly in the early years of medical school are at increased risk for professional misconduct later in their careers.", "negatives": ["Students who perform poorly in the early years of medical school are at increased risk for professional misconduct later in their careers.", "The mean suicide rate in women is higher after miscarriage than live birth.", "Increased microtubule acetylation exacerbates LRRK2 Roc-COR domain mutation induced locomotor deficits.", "Surfactin producing cells and exopolymer producing cells cooperate to generate \"Van Gogh\" bundles that have sliding abilities on specialized media.", "Side effects associated with antidepressants do not represent a mortality risk to postmenopausal women.", "Mice defective for deoxyribonucleic acid (DNA) polymerase I (polI) fail to reveal increased sensitivity to ionizing radiation (IR).", "Perigenital skin is not the primary site of HIV acquisition.", "Upregulation of PD1 causes the upregulation of Satb1.", "The density of cytokine receptor bearing cells affects the distance over which cytokines act.", "Aggravated inflammation is dependent on NLRP3 inflammasome activation."], "hard_negatives": ["A diminished ovarian reserve is a very strong indicator of infertility, even in an a priori non-infertile population.", "A diminished ovarian reserve does not solely indicate infertility in an a priori non-infertile population.", "Diminished ovarian reserve is a reliable indicator of infertility in a non-infertile population.", "The mean suicide rate in women is lower after miscarriage than live birth.", "The mean suicide rate in women is higher after miscarriage than live birth.", "The risk of breast cancer among parous women decreases with placental weight of pregnancies.", "The number of unfertilized oocytes in mated hermaphrodites increases with age.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have shorter lifetime exposure to estrogen due to a decreased reproductive period.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have longer lifetime exposure to estrogen due to an increased reproductive period.", "Women with a lower birth weight are more likely to develop breast cancer later in life."], "hard_negative": "A diminished ovarian reserve is a very strong indicator of infertility, even in an a priori non-infertile population."}
{"query_id": "41", "query_text": "A high microerythrocyte count protects against severe anemia in homozygous alpha (+)- thalassemia trait subjects.", "negative": "50% of patients exposed to radiation have activated markers of mesenchymal stem cells.", "negatives": ["50% of patients exposed to radiation have activated markers of mesenchymal stem cells.", "Adult tissue-resident macrophages are seeded before birth.", "Treatment with a protein named FN impairs regenerative abilities of aged muscles.", "Diabetic patients with acute coronary syndrome experience decreased short-term and long-term risk for bleeding events.", "Many cytokines that are produced by cancer cells also contribute to carcinogenesis.", "Two variants of chromosome 6q21 are associated with radiation therapy-induced second malignancies in pediatric Hodgkin lymphoma patients.", "Bariatric surgery leads to positive outcomes in mental health.", "Increased mobility of retrotransposons does not lead to mutation and higher tumorigenesis rates.", "Deleting Raptor increases G-CSF levels.", "Diabetic patients with acute coronary syndrome experience decreased short-term and long-term risk for bleeding events."], "hard_negatives": ["A high microerythrocyte count protects against severe anemia in homozygous alpha (+)- thalassemia trait subjects.", "A deficiency of vitamin B6 decreases blood levels of homocysteine.", "A deficiency of vitamin B12 decreases blood levels of homocysteine.", "HbA1c consistently overestimates glycemic control in black individuals with Sickle cell trait (SCT).", "Mice without IFN-\u03b3 or its receptor are highly susceptible to EAM induced with \u03b1-MyHC/CFA.", "A deficiency of folate increases blood levels of homocysteine.", "The removal of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells.", "The generation of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells.", "Carriers of HNF4A mutations are at reduced risk for diabetes.", "HNF4A mutations are associated with macrosomia in infancy."], "hard_negative": "A high microerythrocyte count protects against severe anemia in homozygous alpha (+)- thalassemia trait subjects."}
{"query_id": "43", "query_text": "A low percentage of hematopoietic progenitor cells are susceptible to HIV-1 infection ex vivo.", "negative": "Pyridostatin decreases telomere fragility in BRCA2-deficient cells.", "negatives": ["Pyridostatin decreases telomere fragility in BRCA2-deficient cells.", "Incidence of 10/66 dementia is higher than the incidence of DSM-IV dementia.", "Reduced phosphorylation of PP2A suppresses HDAC4 dephosphorylation.", "Higher plasma levels of I-carnitine, when associated with trimethylamine N-oxide, are negatively correlated with cardiovascular events in humans.", "A high microerythrocyte count protects against severe anemia in homozygous alpha (+)- thalassemia trait subjects.", "In rhesus macaques, daily subcutaneous injections of emtricitabine are ineffective at protecting against rectally transmitted simian-human immunodeficiency virus.", "cSMAC formation represses weak ligand signalling.", "Post-transcriptional handling of mitochondrial transcripts occurs in mitochondrial RNA granules.", "ART has no effect on the infectiveness of HIV-positive people.", "Origin gross domestic product(GDP) is negatively related to dengue virus (DENV-1) diffusion in air traffic shipments."], "hard_negatives": ["A low percentage of hematopoietic progenitor cells are susceptible to HIV-1 infection ex vivo.", "The HSV-2 infection is typically asymptomatic.", "Perigenital skin is not the primary site of HIV acquisition.", "Chronic HIV stimulation of B cells leads to the premature exhaustion of B cells.", "The latent infection of myeloid cells with human cytomegalovirus induces a number of changes in gene expression.", "Exhaustion of B cells contributes to poor Ab response in HIV-infected individuals.", "Approximately 250,000 people are infected with human T-cell lymphotropic virus type 1 in the United Kingdom.", "Hematopoietic Stem Cell purification reaches purity rates above 90%.", "Nonhuman primates are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.", "Malaria has a high vectorial capacity."], "hard_negative": "A low percentage of hematopoietic progenitor cells are susceptible to HIV-1 infection ex vivo."}
{"query_id": "44", "query_text": "A mutation in HNF4A leads to an increased risk of developing diabetes by the age of 14 years.", "negative": "Ectopic expression of Sall4, Nanog, Esrrb, and Lin28 generates induced pluripotent stem cells from mouse embryonic fibroblasts more efficiently than other factor combinations.", "negatives": ["Ectopic expression of Sall4, Nanog, Esrrb, and Lin28 generates induced pluripotent stem cells from mouse embryonic fibroblasts more efficiently than other factor combinations.", "Type 1 Diabetes is associated with subtle perturbations in T reg development.", "Lack of FGF21 in mice leads to atherosclerotic plaque formation.", "5'-nucleotidase metabolizes 6MP.", "Gpr124 suppresses BBB breakdown in mouse models of ischemic stroke.", "Ca2+ cycling is a UCP1-dependent thermogenic mechanism.", "In pediatric tissue, most T cells are naive T cell emigrants from the thymus.", "Ten percent (10%) of kidney cancers in the UK are attributable to excess weight.", "Transcription rates in S. cerevisiae range between 0.7 and 2 kb/min.", "The origin of the CRF01_1b2k protein occurred between 1923 and 1956."], "hard_negatives": ["A mutation in HNF4A leads to an increased risk of developing diabetes by the age of 14 years.", "A mutation in HNF4A leads to an increased risk of diabetes by the age of 14 years.", "Carriers of HNF4A mutations are at reduced risk for diabetes.", "HNF4A mutations are associated with macrosomia in infancy.", "There is no association between HNF4A mutations and diabetes risks.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have increased risk for Alzheimer's disease.", "Autophagy deficiency in the liver increases vulnerability to insulin resistance.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have decreased risk for dementia.", "A deficiency of vitamin B12 decreases blood levels of homocysteine.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have shorter lifetime exposure to estrogen due to a decreased reproductive period."], "hard_negative": "A mutation in HNF4A leads to an increased risk of developing diabetes by the age of 14 years."}
{"query_id": "45", "query_text": "A mutation in HNF4A leads to an increased risk of diabetes by the age of 14 years.", "negative": "Localization of PIN1 in the roots of Arabidopsis requires VPS9a", "negatives": ["Localization of PIN1 in the roots of Arabidopsis requires VPS9a", "CD28 signals regulate trafficking of murine auto-reactive T cells into target tissues.", "A deficiency of vitamin B12 decreases blood levels of homocysteine.", "Active H. pylori urease has a polymeric structure consisting of five distinct subunits.", "Alteration of origin firing causes changes in termination zones of Okazaki fragments.", "Gastric lavage is an effective treatment for acute paraquat poisoning.", "Ca2+ cycling controls whole-body energy homeostasis in beige fat.", "Human embryonic stem cells give rise to cell types from all three embryonic germ layers.", "Origin gross domestic product(GDP) is positively related to dengue virus (DENV-1) diffusion in air traffic shipments.", "Tonic signaling from the scFv induces constitutive stimulation."], "hard_negatives": ["A mutation in HNF4A leads to an increased risk of developing diabetes by the age of 14 years.", "A mutation in HNF4A leads to an increased risk of diabetes by the age of 14 years.", "Carriers of HNF4A mutations are at reduced risk for diabetes.", "HNF4A mutations are associated with macrosomia in infancy.", "There is no association between HNF4A mutations and diabetes risks.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have increased risk for Alzheimer's disease.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have decreased risk for dementia.", "Autophagy deficiency in the liver increases vulnerability to insulin resistance.", "A deficiency of vitamin B12 decreases blood levels of homocysteine.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have shorter lifetime exposure to estrogen due to a decreased reproductive period."], "hard_negative": "A mutation in HNF4A leads to an increased risk of developing diabetes by the age of 14 years."}
{"query_id": "46", "query_text": "A single nucleotide variant the gene DGKK is strongly associated with increased risk of hypospadias.", "negative": "The risk of cancer rises with level of alcohol consumption.", "negatives": ["The risk of cancer rises with level of alcohol consumption.", "Continued HHV-8 transmission among MSM in San Francisco may be explained by urogenital contact.", "Long chain polyunsaturated fatty acids supplementation reduces wheezing and asthma.", "APOE4 expression in iPSC-derived neurons results in decreased tau phosphorylation.", "The artifactual C-terminal helix swapping in the StART domain is observed in the Ups1-Mdm35 heterodimer of the StARkin superfamily.", "Women are more susceptible to death due to pneumonia when compared to men.", "Lamins are found within the inner layer of the nuclear membrane of all cells.", "\u03b2-sheet opening occurs during pleurotolysin pore formation.", "p16INK4A degradation is  linked to an abnormal wound response caused by the microinvasive step of advanced Oral Potentially Malignant Lesions (OPMLs).", "CCL19 is predominantly present within dLNs."], "hard_negatives": ["A single nucleotide variant the gene DGKK is strongly associated with increased risk of hypospadias.", "HNF4A mutations are associated with macrosomia in infancy.", "The G34R/V mutation does not create a hypomethylated phenotype at the H3K36 histone.", "The G34R/V mutation creates a hypomethylated phenotype at the H3K36 histone.", "Carriers of HNF4A mutations are at reduced risk for diabetes.", "The minor G allele of FOXO3 is related to less severe symptoms of Crohn's Disease.", "Incidence of 10/66 dementia is higher than the incidence of DSM-IV dementia.", "Incidence of 10/66 dementia is lower than the incidence of DSM-IV dementia.", "Mutations in G-Beta protein GNB1 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.", "There is no association between HNF4A mutations and diabetes risks."], "hard_negative": "A single nucleotide variant the gene DGKK is strongly associated with increased risk of hypospadias."}
{"query_id": "47", "query_text": "A strong bias in the phage genome locations where the spacers were derived has been observed in many CRISPR subtypes that confer the immunity to phage.", "negative": "Cardiac tissue-resident macrophages directly contribute to electrical activity.", "negatives": ["Cardiac tissue-resident macrophages directly contribute to electrical activity.", "Patients with microcytosis and higher erythrocyte count were more resistant to severe malarial anaemia when infected with Plasmodium falciparum.", "The tissue surrounding the granuloma in an immune cell induces an anti-inflammatory immune response.", "A 100g dose of chloroquine chemoprophylactic regimen results in retinal toxicity after 5-6 years of weekly intake.", "In breast cancer, the loss of myoepithelial cells slows the transition of ductal carcinoma in situ to invasive carcinoma.", "IFIT1 speeds viral replication by allowing for the proliferation of mis-capped viral RNAs.", "The NF-\u03baB essential modulator gene prevents intestinal inflammation by inhibiting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death.", "The composition of myosin-II isoform switches from the A isoform to the B isoform during hematopoietic differentiation.", "Immune complex triggered cell death leads to sequestration of oxidized mitochondrial DNA.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have decreased risk for dementia."], "hard_negatives": ["A strong bias in the phage genome locations where the spacers were derived has been observed in many CRISPR subtypes that confer the immunity to phage.", "Nonhuman primates are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.", "Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 encourage West Nile virus replication in cortical neurons.", "Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 inhibit West Nile virus replication in cortical neurons.", "Eilat virus (EILV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in nonhuman primates.", "Understanding epigenetic regulation of replication is essential for the reational design of episomally replicating vectors.", "Sequence conservation in gene regulatory regions between species is a poor predictor of conserved functionality.", "Upon viral challenge, influenza-specific memory CD4+ T cells greatly diminish the early production of inflammatory chemokines in the lung.", "In S. cerevisiae, the absence of RNA surveillance pathways reduces sensitivity to high iron conditions.", "Upon viral challenge, influenza-specific memory CD4+ T cells greatly enhance the early production of inflammatory chemokines in the lung."], "hard_negative": "A strong bias in the phage genome locations where the spacers were derived has been observed in many CRISPR subtypes that confer the immunity to phage."}
{"query_id": "52", "query_text": "ALDH1 expression is associated with poorer prognosis for breast cancer primary tumors.", "negative": "The peak incidence of fractures occurs during pubertal growth spurt in early adolescents.", "negatives": ["The peak incidence of fractures occurs during pubertal growth spurt in early adolescents.", "Patients with microcytosis and higher erythrocyte count were more resistant to severe malarial anaemia when infected with Plasmodium falciparum.", "Rapamycin increases the concentration of triacylglycerols in fruit flies.", "Immune responses in immune cells are geographically segregated.", "N348I mutations cause resistance to nevirapine.", "Pyridostatin induces double-strand breaks accumulation.", "Antidepressants increase the severity of migraines.", "Nonsteroidal antinflammatory drugs show potential anticancer indications.", "Deletion of ATM and Rad3 related protein is not predictive of acute tissue loss.", "Microcin J25 inhibits nucleoside triphosphate (NTP) binding."], "hard_negatives": ["ALDH1 expression is associated with poorer prognosis for breast cancer primary tumors.", "TNFAIP3 is a tumor enhancer in glioblastoma.", "Normal expression of RUNX1 causes tumorsupressing effects.", "TNFAIP3 is a glioblastoma tumor enhancer.", "TNFAIP3 is a glioblastoma tumor suppressor.", "BRCA 1 mutation carriers' risk of breast and ovarian cancer depends on where the mutation is located.", "Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes epithelial damage.", "Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes fibrosis.", "Low expression of miR7a does not repress target genes or exert a biological function in ovaries.", "GATA3 regulates cell cycle progression in bone marrow hematopoietic stem cells."], "hard_negative": "ALDH1 expression is associated with poorer prognosis for breast cancer primary tumors."}
{"query_id": "55", "query_text": "AMP-activated protein kinase (AMPK) activation reduces inflammation-related fibrosis in the lungs.", "negative": "Prescribed exercise training improves quality of life.", "negatives": ["Prescribed exercise training improves quality of life.", "Expression of oncolytic virus antigens as peptides permits additional protection against relapse.", "Two variants of chromosome 6q21 are associated with radiation therapy-induced second malignancies in pediatric Hodgkin lymphoma patients.", "Transplanted human glial progenitor cells can mature in their host animal.", "Side effects associated with antidepressants do not represent a mortality risk to postmenopausal women.", "A breast cancer patient's capacity to metabolize tamoxifen influences treatment outcome.", "Ly6C hi monocytes have a higher inflammatory capacity than Ly6C lo monocytes.", "Risk of cardiovascular events can be cut by a third by using antihypertensive drug therapy among hemodialysis patients.", "Foxp3 enables the expression of transcriptional regulators implicated in memory T cell development.", "LDL cholesterol has a causal role in the development of cardiovascular disease."], "hard_negatives": ["AMP-activated protein kinase (AMPK) activation reduces inflammation-related fibrosis in the lungs.", "Increased lipolysis leads to higher P38 phosphorylation in adipose tissue.", "Reduced levels of lipolysis leads to higher P38 phosphorylation in adipose tissue.", "Cancer-associated fibroblasts (CAFs) interact with cancer cells to mediate formation and activation of CAFs.", "The cytokine receptor which regulates chemotaxis and formation of lymph nodes is involved in production of myeloperoxidase in the left atrium.", "High levels of CRP lead to a higher risk of exacerbations in chronic obstructive pulmonary disease (COPD).", "Cancer-associated fibroblasts (CAFs) have no known interaction with cancer cells in the formation and activation of CAFs.", "The effect of Lipopolysaccharides on kidney barrier function is dependent on inflammation levels.", "Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes fibrosis.", "Increased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm."], "hard_negative": "AMP-activated protein kinase (AMPK) activation reduces inflammation-related fibrosis in the lungs."}
{"query_id": "58", "query_text": "APOE4 expression in iPSC-derived neurons results in decreased tau phosphorylation.", "negative": "Propriospinal interneurons that play a role in the plastic reorganization of spinal circuits are integral for recovery from spinal cord injury.", "negatives": ["Propriospinal interneurons that play a role in the plastic reorganization of spinal circuits are integral for recovery from spinal cord injury.", "In transgenic mice harboring green florescent protein under the control of the Sox2 promoter, more than 50 percent of the cells with green florescent colocalize with cell proliferation markers.", "Elevated cell-free mitochondrial DNA levels are associated with mortality.", "Oxidative DNA damage activates STING signalling.", "CD44v6 is not associated with constitutive and reprogrammed cancer stem cells driving cancer metastasis.", "V-9302 inhibits antitumor responses by decreasing cell death and oxidative stress.", "Physical activity level is associated with the difference in maximal oxygen consumption between black and white youth.", "Distant CREs are less conserved among species.", "Cytosolic proteins bind to iron-responsive elements on mRNAs coding for TFRC1.", "IL-6 signaling plays a major role in atherosclerotic cardiovascular disease."], "hard_negatives": ["APOE4 expression in iPSC-derived neurons results in decreased tau phosphorylation.", "Reduced levels of lipolysis leads to higher P38 phosphorylation in adipose tissue.", "Increased lipolysis leads to higher P38 phosphorylation in adipose tissue.", "Converting apoE4 to apoE3 by gene editing worsens the pathology associated with apoE4 in human iPSCderived neurons.", "Converting apoE4 to apoE3 by gene editing prevents the pathology associated with apoE4 in human iPSCderived neurons.", "Foxp3 represses the expression of transcriptional regulators implicated in memory T cell development.", "Mice lacking Sirt1 in Sf1-expressing neurons have increased susceptibility to diet-induced obesity and insulin resistance.", "MFGE8 regulates fat absorption by binding to av-Beta3 and av-Beta5 integrins.", "Foxp3 enables the expression of transcriptional regulators implicated in memory T cell development.", "Reduced phosphorylation of PP2A suppresses HDAC4 dephosphorylation."], "hard_negative": "APOE4 expression in iPSC-derived neurons results in decreased tau phosphorylation."}
{"query_id": "60", "query_text": "ART has no effect on the infectiveness of HIV-positive people.", "negative": "Differentiated E2f-1, -2, -3 TKO cells in the intestine do not exhibit apoptosis.", "negatives": ["Differentiated E2f-1, -2, -3 TKO cells in the intestine do not exhibit apoptosis.", "KLF4 is necessary for VSMCs to gain genetic characteristics of other cell types within atherosclerotic lesions.", "Self-advocacy training is effective at decreasing homelessness.", "Pyridostatin deregulates G2/M progression.", "Venules have less significant tunica adventitia than arterioles.", "Inhibiting glucose-6-phospate dehydrogenase improves lipogenesis by deactivating LKB1-AMPK signaling.", "The World Health Organization's (WHO) data collection process is biased downward by unequal selection of larger outbreaks.", "NR5A2 does not play a role in development of endometrial tissues.", "Klf4 is not required for proper myeloid cell differentiation.", "In British Men, haplogroup I increases risk of cardiovascular disease by 50%."], "hard_negatives": ["ART has no effect on the infectiveness of HIV-positive people.", "ART substantially reduces infectiveness of HIV-positive people.", "Having a main partner worsens HIV outcomes.", "Perigenital skin is not the primary site of HIV acquisition.", "Patients in stable partnerships have a slower progression from HIV to AIDS.", "Exhaustion of B cells contributes to poor Ab response in HIV-infected individuals.", "Patients in stable partnerships progress from HIV to death at the same rate as patients not in partnerships.", "Chronic HIV stimulation of B cells leads to the premature exhaustion of B cells.", "Having a main partner improves HIV outcomes.", "A low percentage of hematopoietic progenitor cells are susceptible to HIV-1 infection ex vivo."], "hard_negative": "ART has no effect on the infectiveness of HIV-positive people."}
{"query_id": "61", "query_text": "ART substantially reduces infectiveness of HIV-positive people.", "negative": "A deficiency of vitamin B6 decreases blood levels of homocysteine.", "negatives": ["A deficiency of vitamin B6 decreases blood levels of homocysteine.", "Post-transcriptional handling of mitochondrial transcripts occurs in mitochondrial RNA granules.", "Antimicrobial agents are more effective due to the pressure of antimicrobial usage.", "In breast cancer, the loss of myoepithelial cells promotes the transition of ductal carcinoma in situ to invasive carcinoma.", "There is no increased risk of hypospadias with clomiphene.", "Reduced responsiveness to interleukin-2 in regulatory T cells is associated with autoimmune diseases such as Type 1 Diabetes.", "Pioneer factor OCT3/4 interacts with major chromatin remodeling factors.", "Cis-acting lncRNAs control the expression of genes that are positioned in the vicinity of their transcription sites.", "Lack of FGF21 in mice leads to reduced lifespan.", "The one-child policy has created a hospitable environment for female infants."], "hard_negatives": ["ART substantially reduces infectiveness of HIV-positive people.", "ART has no effect on the infectiveness of HIV-positive people.", "Exhaustion of B cells contributes to poor Ab response in HIV-infected individuals.", "Patients in stable partnerships have a slower progression from HIV to AIDS.", "Perigenital skin is not the primary site of HIV acquisition.", "Having a main partner worsens HIV outcomes.", "Having a main partner improves HIV outcomes.", "Patients in stable partnerships progress from HIV to death at the same rate as patients not in partnerships.", "Antiretroviral therapy increases rates of tuberculosis across a broad range of CD4 strata.", "Chronic HIV stimulation of B cells leads to the premature exhaustion of B cells."], "hard_negative": "ART substantially reduces infectiveness of HIV-positive people."}
{"query_id": "62", "query_text": "ATF4 is a general endoplasmic reticulum stress marker.", "negative": "The US health care system can save up to $5 billion if 7% of patients waiting for kidney transplants participate in the optimized national kidney paired donation program.", "negatives": ["The US health care system can save up to $5 billion if 7% of patients waiting for kidney transplants participate in the optimized national kidney paired donation program.", "B cells go though plasmablast differentiation and antibody production by continuous expression of EBI2.", "The minor G allele of FOXO3 up-regulates IL-10.", "The latent infection of myeloid cells with human cytomegalovirus induces a number of changes in gene expression.", "Walking in traffic areas in London improves lung function in elderly adults.", "Pyridostatin decreases telomere fragility in BRCA2-deficient cells.", "ATM and Rad3 related protein are critical for sensing DNA damage.", "Tonic signaling from the scFv prevents constitutive stimulation.", "Higher plasma levels of I-carnitine, when associated with trimethylamine N-oxide, are positively correlated with cardiovascular events in humans.", "NR5A2 is important in reverse cholesterol transport in humans."], "hard_negatives": ["ATF4 is a general endoplasmic reticulum stress marker.", "BiP is a general endoplasmic reticulum stress marker.", "CHOP is a general endoplasmic reticulum stress marker.", "4-PBA treatment decreases endoplasmic reticulum stress in response to general endoplasmic reticulum stress markers.", "4-PBA treatment raises endoplasmic reticulum stress in response to general endoplasmic reticulum stress markers.", "Ribosomal protein (RP) expression is controlled in part by stress-activated regulators.", "Deltex has no known interactions with eIF3f.", "MFGE8 regulates fat absorption by binding to av-Beta3 and av-Beta5 integrins.", "KRT17 modulates the expression of the transcriptional regulator AIRE in diseased epithelia.", "Mice lacking Sirt1 in Sf1-expressing neurons have increased susceptibility to diet-induced obesity and insulin resistance."], "hard_negative": "ATF4 is a general endoplasmic reticulum stress marker."}
{"query_id": "63", "query_text": "ATM and Rad3 related protein are critical for sensing DNA damage.", "negative": "Deletion of ATM and Rad3 related protein is not predictive of acute tissue loss.", "negatives": ["Deletion of ATM and Rad3 related protein is not predictive of acute tissue loss.", "Taxation of sugar-sweetened beverages reduced the incidence rate of type II diabetes in India.", "Approximately 250,000 people are infected with human T-cell lymphotropic virus type 1 in the United Kingdom.", "Immune responses in immune cells are geographically segregated.", "Post-transcriptional handling of mitochondrial transcripts occurs in mitochondrial RNA granules.", "LDL cholesterol has a causal role in the development of cardiovascular disease.", "Smc5/6 engagment halts the activation of SUMO E3 ligase Mms21 by ATP-dependent remolding.", "Increased mobility of retrotransposons is assosciated with mutation and higher tumorigenesis rates.", "Lamins are found within the inner layer of the mitochondrial membrane of all cells.", "Persister cells provide relapse resistance in cancer patients."], "hard_negatives": ["ATM and Rad3 related protein are critical for sensing DNA damage.", "ATM and Rad3 related protein have no role in sensing DNA damage.", "Deletion of ATM and Rad3 related protein leads to acute tissue loss.", "Deletion of ATM and Rad3 related protein is not predictive of acute tissue loss.", "Activated Cdk5 phosphorylates the ATM protein in response to DNA damage.", "RAD52 is involved in break-induced DNA replication (BIR).", "Toll-like receptor (TLR) signaling is involved in the pathogenesis of human MDS.", "Gpr124 suppresses BBB breakdown in mouse models of ischemic stroke.", "Replacement of OCT4 and SOX2 genes with GATA3 has the ability to reprogram human cells.", "CD28 signals regulate trafficking of murine auto-reactive T cells into target tissues."], "hard_negative": "ATM and Rad3 related protein are critical for sensing DNA damage."}
{"query_id": "64", "query_text": "ATM and Rad3 related protein have no role in sensing DNA damage.", "negative": "Radioiodine treatment of non-toxic multinodular goitre increases thyroid volume.", "negatives": ["Radioiodine treatment of non-toxic multinodular goitre increases thyroid volume.", "Cnn1 recruitment varies with cell cycle timing.", "A deficiency of vitamin B6 decreases blood levels of homocysteine.", "Kir7.1 modulates channel activity by the G protein-coupled melanocortin-4 receptor (MC4R) in the paraventricular nucleus of the hypothalamus.", "Whole brain radiotherapy increases the occurrence of new brain metastases.", "A deficiency of vitamin B6 decreases blood levels of homocysteine.", "Ethanol stress increases the expression of PSP in bacteria.", "Pyridostatin decreases telomere fragility in BRCA2-deficient cells.", "Treatment with the EC uptake inhibitor AM404 resulted in a dose-dependent decrease in the expression of immobility.", "V-9302 inhibits antitumor responses by decreasing cell death and oxidative stress."], "hard_negatives": ["ATM and Rad3 related protein have no role in sensing DNA damage.", "ATM and Rad3 related protein are critical for sensing DNA damage.", "Deletion of ATM and Rad3 related protein leads to acute tissue loss.", "Deletion of ATM and Rad3 related protein is not predictive of acute tissue loss.", "Activated Cdk5 phosphorylates the ATM protein in response to DNA damage.", "RAD52 is involved in break-induced DNA replication (BIR).", "Toll-like receptor (TLR) signaling is involved in the pathogenesis of human MDS.", "Gpr124 suppresses BBB breakdown in mouse models of ischemic stroke.", "Replacement of OCT4 and SOX2 genes with GATA3 is not capable of reprogramming human cells.", "Replacement of OCT4 and SOX2 genes with GATA3 has the ability to reprogram human cells."], "hard_negative": "ATM and Rad3 related protein have no role in sensing DNA damage."}
{"query_id": "66", "query_text": "AZT given with ribavirin increases anemia.", "negative": "Physical activity does not improve cognitive function in individuals with Alzheimers.", "negatives": ["Physical activity does not improve cognitive function in individuals with Alzheimers.", "Citrullinated proteins externalized in neutrophil extracellular traps act indirectly to perpetuate the inflammatory cycle via induction of autoantibodies.", "Upregulation of PD1 causes the downmodulation of Satb1.", "KRT17 modulates the expression of the transcriptional regulator AIRE in diseased epithelia.", "HOXB4 facilitates HSC expansion when co-cultured with HSCs.", "Cholesterol loading induces KLF4 expression in VSMCs, resulting in the expression of pro-inflammatory cytokines.", "Induced hepatic stem cells possess the potential to differentiate into hepatocytic cells.", "Progerin induces premature aging in stem cells.", "Mutant mice lacking SVCT2 have severely reduced ascorbic acid levels in both brain and adrenals.", "Excess gestational weight gain is associated with obesity-related pregnancy outcomes."], "hard_negatives": ["AZT given with ribavirin increases anemia.", "Antidepressants increase the severity of migraines.", "Taking anti-depresents is associated with a decrease in the A\u03b2 level in the brain of experimental animals.", "Alirocumab treatment reduces apo(a) fractional clearance rate.", "Antidepressants reduce the severity of migraines.", "Side effects associated with antidepressants increases risk of stroke.", "Antiretroviral therapy increases rates of tuberculosis across a broad range of CD4 strata.", "Side effects associated with antidepressants lower risk of myocardial infarction.", "A deficiency of folate increases blood levels of homocysteine.", "The most prevalent adverse events to Semaglutide are gastrointestinal."], "hard_negative": "AZT given with ribavirin increases anemia."}
{"query_id": "67", "query_text": "Activated Cdk5 phosphorylates the ATM protein in response to DNA damage.", "negative": "Nonsteroidal antinflammatory drugs are ineffective as cancer treatments.", "negatives": ["Nonsteroidal antinflammatory drugs are ineffective as cancer treatments.", "Prescribed exercise training improves quality of life.", "The repeat-variable diresidue (RVD) in the loop of Transcription-Activator Like (TAL) effectors specifies the nucleotides-amino acid contact at the target promoter element.", "Folate and vitamin B12 levels influence the association between homocysteine and preeclampsia.", "Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 inhibit West Nile virus replication in cortical neurons.", "eRNAs influence is linked to senescence, aging, and carcinogenesis.", "Active Ly49Q induces neutrophil polarization.", "MafA phosphorylation decreases its ubiquitination.", "Physical activity level is associated with the difference in maximal oxygen consumption between black and white youth.", "Taking anti-depresents is associated with a decrease in the A\u03b2 level in the brain of experimental animals."], "hard_negatives": ["Activated Cdk5 phosphorylates the ATM protein in response to DNA damage.", "Activated Cdk5 regulates DNA damage-induced neuronal death.", "Deletion of ATM and Rad3 related protein leads to acute tissue loss.", "ATM and Rad3 related protein have no role in sensing DNA damage.", "ATM and Rad3 related protein are critical for sensing DNA damage.", "Deletion of ATM and Rad3 related protein is not predictive of acute tissue loss.", "CD28 signals regulate trafficking of murine auto-reactive T cells into target tissues.", "ITAM phosphorylation allows for the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).", "Binding of p53 to enhancer regions (p53BERs) regulates the activity of p53 transcription and cell cycle arrest through the production of p53-dependent eRNAs.", "Toll-like receptor (TLR) signaling is involved in the pathogenesis of human MDS."], "hard_negative": "Activated Cdk5 phosphorylates the ATM protein in response to DNA damage."}
{"query_id": "68", "query_text": "Activated Cdk5 regulates DNA damage-induced neuronal death.", "negative": "Converting apoE4 to apoE3 by gene editing prevents the pathology associated with apoE4 in human iPSCderived neurons.", "negatives": ["Converting apoE4 to apoE3 by gene editing prevents the pathology associated with apoE4 in human iPSCderived neurons.", "Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection decreases dissemination of Salmonella Typhimurium from the gut.", "HOXB4 is a highly expressed component of cellular secretome from fetal liver cell populations.", "Taking anti-depresents is associated with a decrease in the A\u03b2 level in the brain of experimental animals.", "Walking in traffic areas in London improves lung function in elderly adults.", "siRNA knockdown of A20 slows tumor progression in an in vivo murine xenograft model.", "Ribosomal protein (RP) expression is controlled in part by stress-activated regulators.", "The G34R/V mutation does not create a hypomethylated phenotype at the H3K36 histone.", "A diminished ovarian reserve does not solely indicate infertility in an a priori non-infertile population.", "Cis-acting lncRNAs control the expression of genes that are positioned in the vicinity of their transcription sites."], "hard_negatives": ["Activated Cdk5 regulates DNA damage-induced neuronal death.", "Activated Cdk5 phosphorylates the ATM protein in response to DNA damage.", "Binding of p53 to enhancer regions (p53BERs) regulates the activity of p53 transcription and cell cycle arrest through the production of p53-dependent eRNAs.", "FoxO3a activation in neuronal death is inhibited by reactive oxygen species (ROS).", "Activation of PPM1D enhances p53 function.", "CD28 initiates tonic signaling in conventional T cells, which causes an exhaustion phenotype and limited efficiency.", "Up-regulation of the p53 pathway and related molecular events speeds cancer progression.", "PD-1 triggering on monocytes enhances IL-10 production by monocytes.", "IL-10 production by monocytes inhibits CD4 + T cell response.", "CD28 signals regulate trafficking of murine auto-reactive T cells into target tissues."], "hard_negative": "Activated Cdk5 regulates DNA damage-induced neuronal death."}
{"query_id": "69", "query_text": "Activation of PPM1D enhances p53 function.", "negative": "Adult tissue-resident macrophages stem from the embryonal yolk sac and fetal liver.", "negatives": ["Adult tissue-resident macrophages stem from the embryonal yolk sac and fetal liver.", "\u03b21/Ketel is able to bind microtubules.", "Cellular clocks are not predictive of mitosis timing in NIH 3T3 cells.", "Treatment with a protein named FN impairs regenerative abilities of aged muscles.", "In S. cerevisiae, the absence of RNA surveillance pathways reduces sensitivity to high iron conditions.", "Removal of H3K9me3 improves reprogramming efficiency in human somatic cell nuclear transfer experiments.", "Gastric infection with Helicobacter pylori increases risk of gastric cancer in humans.", "Sympathetic nerve activity is elevated throughout normal pregnancy.", "The Snf1 complex regulates carbon and energy metabolism in baker's yeast (Saccharomyces cerevisiae).", "Healthy volunteers exhibit rapid and transient increase of cellular ATP after being bolus-injected with fructose."], "hard_negatives": ["Activation of PPM1D enhances p53 function.", "Binding of p53 to enhancer regions (p53BERs) regulates the activity of p53 transcription and cell cycle arrest through the production of p53-dependent eRNAs.", "Activated Cdk5 regulates DNA damage-induced neuronal death.", "Up-regulation of the p53 pathway and related molecular events speeds cancer progression.", "p16INK4A degradation is encoded by CDKN2A.", "MeCP2 influences the synaptic maturation of neurons.", "Activated Cdk5 phosphorylates the ATM protein in response to DNA damage.", "PD-1 triggering on monocytes enhances IL-10 production by monocytes.", "Upregulation of PD1 causes the downmodulation of Satb1.", "Upregulation of PD1 causes the upregulation of Satb1."], "hard_negative": "Activation of PPM1D enhances p53 function."}
{"query_id": "71", "query_text": "Activation of the Rac1 homolog CED-10 kills viable cells in SRGP-1 mutant Caenorhabditis elegans.", "negative": "N348I mutations reduce resistance to nevirapine.", "negatives": ["N348I mutations reduce resistance to nevirapine.", "EG7 tumors can be killed by systemic oxaliplatin primed CD8+ T cells from the tumor-draining lymph node cells.", "COPI coatmer is involved in lipid homeostasis.", "Depletion of nitric oxide is responsible for vasospasm.", "Homozygous deletion of murine Sbds gene from osterix-expressing mesenchymal stem and progenitor cells (MPCs) induces oxidative stress.", "Microglia are an innate immune cell type of the peripheral nervous system.", "Broadly HIV-1 Neutralizing Antibodies (bnAb) 10EB have no affinity for phospholipids.", "Neutrophils produce IL-1\u03b2 in response to large particles.", "ART substantially reduces infectiveness of HIV-positive people.", "Ca2+ cycling is a UCP1-independent thermogenic mechanism."], "hard_negatives": ["Activation of the Rac1 homolog CED-10 kills viable cells in SRGP-1 mutant Caenorhabditis elegans.", "Activation of PPM1D enhances p53 function.", "PD-1 triggering on monocytes enhances IL-10 production by monocytes.", "Activated Cdk5 regulates DNA damage-induced neuronal death.", "The Snf1 complex regulates carbon and energy metabolism in baker's yeast (Saccharomyces cerevisiae).", "siRNA knockdown of A20 slows tumor progression in an in vivo murine xenograft model.", "The PRDM1 gene is a key determinant of primordial germ cells.", "Localization of PIN1 in the roots of Arabidopsis requires VPS9a", "Gpr124 suppresses BBB breakdown in mouse models of ischemic stroke.", "In a naive state, blocking Wingless-Int-1 secretion from mouse embryonic stem cells inhibits self-renewal of the mouse embryonic stem cells."], "hard_negative": "Activation of the Rac1 homolog CED-10 kills viable cells in SRGP-1 mutant Caenorhabditis elegans."}
{"query_id": "73", "query_text": "Activator-inhibitor pairs are provided ventrally by Xrl-sizzled.", "negative": "HAND2 methylation is a key step in early endometrial carcinogenesis.", "negatives": ["HAND2 methylation is a key step in early endometrial carcinogenesis.", "Increased purity of cytoplasmic membranes isolated from overexpressors is indicated by stronger spots for OmpF in 2D BN-PAGE gels.", "Systemic lupus erythematosus is a risk factor for cardiovascular disease.", "Pro-inflammatory cytokines are up regulated during tumor development.", "KLF4 is necessary for VSMCs to gain genetic characteristics of other cell types within atherosclerotic lesions.", "mcm 5 s 2 U is required for proper decoding of NNR codons in eukaryotes.", "Insulin effects appetite via ventral tegmental neurons.", "In the UK, drowning affects boys and girls equally.", "At least 85% of patients exposed to radiation have activated markers of myofibroblasts.", "Carriers of HNF4A mutations are at reduced risk for diabetes."], "hard_negatives": ["Activator-inhibitor pairs are provided ventrally by Xrl-sizzled.", "Drosophila supracellular actomyosin structures are found at boundaries in wing imaginal discs.", "The C-type lectin receptor (CLEC-2) rearranges the actin cytoskeleton in dendritic cells to promote efficient motility along stromal surfaces.", "Upregulation of dynein in Drosophila neurons increases the number of microtubule plus-ends growing toward the cell body of each neuron.", "ITAM phosphorylation allows for the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).", "IFI16 impedes STING phosphorylation and translocation, resulting in reduced activation of STING.", "C2 works synergistically with A-769662 to activate dephosphorylated AMPK.", "Beta-band coherence is enhanced for visible stimuli over invisible stimuli.", "Beta-band coherence is diminished for visible stimuli over invisible stimuli.", "During the primary early antibody response activated B cells migrate toward the inner-and outer follicular areas where oxysterol accumulation is generated by stromal cells."], "hard_negative": "Activator-inhibitor pairs are provided ventrally by Xrl-sizzled."}
{"query_id": "74", "query_text": "Active H. pylori urease has a polymeric structure consisting of five distinct subunits.", "negative": "ScPif1p has reduced binding ability to G-rich ssDNA compared to non-G-rich ssDNA.", "negatives": ["ScPif1p has reduced binding ability to G-rich ssDNA compared to non-G-rich ssDNA.", "DUSP4 downregulation deactivates the Ras-ERK pathway", "Chinese individuals with TT homozygosity in the MTHFR gene are more vulnerable to strokes caused by low levels of folate intake.", "Higher plasma levels of I-carnitine, when associated with trimethylamine N-oxide, are negatively correlated with cardiovascular events in humans.", "Exercise reduces cancer mortality rates among Chinese citizens.", "Major vault protein regulates sorting of tumor suppressive miR-193a into EVs.", "KRT17 modulates the expression of the transcriptional regulator AIRE in diseased epithelia.", "Phase information is useful for predicting donor-recipient matches in organ transplantation.", "Suboptimal nutrition is a leading cause of premature death", "CCL19 is predominantly present within dLNs."], "hard_negatives": ["Active H. pylori urease has a polymeric structure consisting of five distinct subunits.", "The deamination of cytidine to uridine on the minus strand of viral DNA can inactivate the viral genome by inducing G-to-A mutations.", "The composition of myosin-II isoform switches from the A isoform to the B isoform during hematopoietic differentiation.", "Formation of N-terminal pyroglutamate by glutamine cyclase (GC) competes with NTAQ1 for Nt-Gln substrates.", "Emodin forms hydrogen bonds with residues involved in PGAM1 substrate binding.", "Thiopurine active metabolites can be catabolized through dephosphorylation of thioguanine nucleotides.", "The predominant localization of Linc00173 is in mononuclear macrophage nuclei.", "The C-type lectin receptor (CLEC-2) rearranges the actin cytoskeleton in dendritic cells to promote efficient motility along stromal surfaces.", "The Snf1 complex regulates carbon and energy metabolism in baker's yeast (Saccharomyces cerevisiae).", "Ethanol stress reduces the expression of SRL in bacteria."], "hard_negative": "Active H. pylori urease has a polymeric structure consisting of five distinct subunits."}
{"query_id": "76", "query_text": "Active Ly49Q induces neutrophil polarization.", "negative": "Having a main partner improves HIV outcomes.", "negatives": ["Having a main partner improves HIV outcomes.", "Treatment with a protein named FN impairs regenerative abilities of aged muscles.", "Cnn1 recruitment varies with cell cycle timing.", "Therapeutics receiving accelerated approval encounter a lower frequency of post-marketing safety events", "The amount of publicly available DNA data doubles every 10 months.", "Cholesterol loading induces KLF4 expression in VSMCs, resulting in the expression of pro-inflammatory cytokines.", "The composition of myosin-II isoform switches from the A isoform to the B isoform during hematopoietic differentiation.", "Intra-cerebroventricular infusion of amyloid-\u03b2 oligomers increases expression of fibronectin type-III domain-containing protein 5 mRNA in mice hippocampi.", "Ribosomopathies have a high degree of cell and tissue specific pathology.", "JMJD6 slows the hydroxylation of C-terminal lysine"], "hard_negatives": ["Active Ly49Q induces neutrophil polarization.", "Active Ly49Q prevents neutrophil polarization.", "Ly49Q directs the organization of neutrophil polarization by regulating membrane raft functions.", "JMJD6 slows the hydroxylation of C-terminal lysine", "Blocking the interaction between TDP-43 and respiratory complex I proteins ND3 and ND6 prevents TDP-43-induced neuronal loss.", "Formation of N-terminal pyroglutamate by glutamine cyclase (GC) competes with NTAQ1 for Nt-Gln substrates.", "Neutrophils produce IL-1\u03b2 in response to large particles.", "Activated Cdk5 phosphorylates the ATM protein in response to DNA damage.", "ITAM phosphorylation allows for the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).", "Activation of PPM1D enhances p53 function."], "hard_negative": "Active Ly49Q induces neutrophil polarization."}
{"query_id": "77", "query_text": "Active Ly49Q prevents neutrophil polarization.", "negative": "NAC destabilizes NO to increase the effect of contrast agents on renal functions.", "negatives": ["NAC destabilizes NO to increase the effect of contrast agents on renal functions.", "There is no increased risk of hypospadias with clomiphene.", "Increased mobility of retrotransposons does not lead to mutation and higher tumorigenesis rates.", "Chinese individuals with TT homozygosity in the MTHFR gene are less vulnerable to strokes caused by low levels of folate intake.", "General exercise therapy is more effective than rotator cuff exercises in reducing pain and improving function of the shoulder.", "British female students are bullied more than British male students.", "Tumor development occurs in conjunction with upregulation of pro-inflammatory cytokines.", "Lamins are found within the inner layer of the nuclear membrane of all cells.", "Mice without IFN-\u03b3 or its receptor are highly susceptible to EAM induced with \u03b1-MyHC/CFA.", "Nonhuman primates are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos."], "hard_negatives": ["Active Ly49Q prevents neutrophil polarization.", "Active Ly49Q induces neutrophil polarization.", "Ly49Q directs the organization of neutrophil polarization by regulating membrane raft functions.", "Blocking the interaction between TDP-43 and respiratory complex I proteins ND3 and ND6 prevents TDP-43-induced neuronal loss.", "JMJD6 slows the hydroxylation of C-terminal lysine", "H4 G94P proteins inhibit chromatin assembly, which decreases free histones.", "Low expression of miR7a does not repress target genes or exert a biological function in testis.", "Activated Cdk5 phosphorylates the ATM protein in response to DNA damage.", "Formation of N-terminal pyroglutamate by glutamine cyclase (GC) competes with NTAQ1 for Nt-Gln substrates.", "Activation of PPM1D enhances p53 function."], "hard_negative": "Active Ly49Q prevents neutrophil polarization."}
{"query_id": "78", "query_text": "Active caspase-11 participate in regulating phagosome-lysosome fusion.", "negative": "Origin gross domestic product(GDP) is positively related to dengue virus (DENV-1) diffusion in air traffic shipments.", "negatives": ["Origin gross domestic product(GDP) is positively related to dengue virus (DENV-1) diffusion in air traffic shipments.", "Human embryonic stem cells have the capacity to give rise to differentiated progeny representative of all three embryonic germ layers.", "Long chain polyunsaturated fatty acids supplementation is associated with lower rates of atopic eczema at 1 year.", "Prescribed exercise training improves quality of life.", "Exercise increases cancer mortality rates among Chinese citizens.", "Inside the body, falciparum parasites reproduce asexually.", "Intake of folic acid (FA) and vitamin B6 (VB6) increases levels of homocysteine.", "CDK6 shows impaired binding to loss-of-function variants of p18 INK4C.", "Women are more susceptible to death due to pneumonia when compared to men.", "NAC destabilizes NO to increase the effect of contrast agents on renal functions."], "hard_negatives": ["Active caspase-11 participate in regulating phagosome-lysosome fusion.", "Active caspase-11 protein promotes pyroptosis.", "Binding of p53 to enhancer regions (p53BERs) regulates the activity of p53 transcription and cell cycle arrest through the production of p53-dependent eRNAs.", "Comparative transcriptome analysis identified new platelet proteins with structural features suggesting a role in platelet function.", "ER-localized phosphatase Sac1 processes PI4P through coordination with OSBP and the endosome-localized protein sorting nexin 2.", "Ly49Q directs the organization of neutrophil polarization by regulating membrane raft functions.", "JMJD6 catalyzes the hydroxylation of C-terminal lysine and supresses transcriptional activity.", "Intramembrane cleavage by signal peptide peptidase aids in the degradation of proteins with a complex membrane orientation.", "Distant CREs are important for transcriptional regulation.", "Foxp3 enables the expression of transcriptional regulators implicated in memory T cell development."], "hard_negative": "Active caspase-11 participate in regulating phagosome-lysosome fusion."}
{"query_id": "79", "query_text": "Active caspase-11 protein promotes pyroptosis.", "negative": "In domesticated populations of Saccharomyces cerevisiae, segmental aneuploidy is very common.", "negatives": ["In domesticated populations of Saccharomyces cerevisiae, segmental aneuploidy is very common.", "The PPR MDA5 has twenty N-terminal CARD domains.", "Intake of folic acid (FA) and vitamin B6 (VB6) reduces levels of homocysteine.", "Gpr124 suppresses BBB breakdown in mouse models of ischemic stroke.", "Pro-inflammatory cytokines are up regulated during tumor development.", "Foxk2 regulates autophagy genes in muscle cells and fibroblast cells.", "The myocardial cell lineage originally develops from cardiac progenitors of exclusively endodermal origin.", "Rising temperatures caused by global warming increases risk of dengue fever transmission.", "Side effects associated with antidepressants increases risk of stroke.", "Distant CREs are important for transcriptional regulation."], "hard_negatives": ["Active caspase-11 protein promotes pyroptosis.", "Active caspase-11 participate in regulating phagosome-lysosome fusion.", "Binding of p53 to enhancer regions (p53BERs) regulates the activity of p53 transcription and cell cycle arrest through the production of p53-dependent eRNAs.", "H4 G94P proteins induce degradation of free histones via Rad53-dependent mechanisms.", "Major vault protein regulates sorting of tumor suppressive miR-193a into EVs.", "H4 G94P proteins suppress degradation of free histones via Rad53-dependent mechanisms.", "Reduced phosphorylation of PP2A increases HDAC4 dephosphorylation by enhancing PP2A-HDAC4 interaction.", "Decrease of p62 in prostate tumor stroma results in defective autophagy.", "APOE4 expression in iPSC-derived neurons results in decreased tau phosphorylation.", "Mitochondria play a major role in apoptosis."], "hard_negative": "Active caspase-11 protein promotes pyroptosis."}
{"query_id": "80", "query_text": "Acute ablation of KRAS causes severe growth impairment.", "negative": "Lack of FGF21 in mice slows the rate of atherosclerotic plaque formation.", "negatives": ["Lack of FGF21 in mice slows the rate of atherosclerotic plaque formation.", "H4 G94P proteins suppress degradation of free histones via Rad53-dependent mechanisms.", "Induced hepatic stem cells possess the potential to differentiate into cholangiocytic cells.", "Nigerian physicians constitue the largest component of sub-Saharan Africa-trained physicians in the United States.", "Exercise reduces cancer mortality rates among Chinese citizens.", "Eilat virus (EILV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in nonhuman primates.", "Increased lipolysis leads to higher P38 phosphorylation in adipose tissue.", "Acute ablation of Snail in the embryonic cortex affects the proliferation and number of embryonic cortical precursors.", "The H2A-H2B eviction defect is compensated for by other histone chaperone(s).", "During non-homologous end joining, the ligation step is not as tolerant of disrepairs and other distortions when joining 3' of strand breaks as compared to 5' strand breaks."], "hard_negatives": ["Acute ablation of KRAS causes severe growth impairment.", "Upon developing tyrosine-kinase inhibitor resistance, new mutations in epidermal growth factor receptors emerge and cause treatment failure.", "B3-Galectin decreases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR.", "B3-Galectin increases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR.", "aPKCz causes tumour suppression by affecting glutamine metabolism.", "Taking 400mg of \u03b1-tocopheryl acetate in combination with vitamin C reduces the risk of prostate cancer.", "Autophagy deficiency in the liver increases vulnerability to insulin resistance.", "Taking 400mg of \u03b1-tocopheryl acetate does not prevent prostate cancer.", "Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes fibrosis.", "AMP-activated protein kinase (AMPK) activation reduces inflammation-related fibrosis in the lungs."], "hard_negative": "Acute ablation of KRAS causes severe growth impairment."}
{"query_id": "81", "query_text": "Acute ablation of Snail in the embryonic cortex affects the proliferation and number of embryonic cortical precursors.", "negative": "Vitamin D is an important factor in the relationship between calcium and parathyroid hormone.", "negatives": ["Vitamin D is an important factor in the relationship between calcium and parathyroid hormone.", "The peak incidence of fractures occurs during pubertal growth spurt in early adolescents.", "Epidemiological disease burden from noncommunicable diseases is more prevalent in high economic settings.", "Tonic signaling from the scFv is amplified by MyD88/CD40.", "Moderate consumption of candy and chocolate reduces the risk of cardiovascular disease (CVD).", "Human embryonic stem cells give rise to cell types from the outer embryonic germ layer, but not the other two layers.", "The proliferative capacity of neural progenitors differs across species.", "The minor G allele of FOXO3 up-regulates IL-10.", "R2D2 stops miRNA production by increasing the selectivity of Dcr2 for long dsRNA.", "Exercise reduces cancer mortality rates among Chinese citizens."], "hard_negatives": ["Acute ablation of Snail in the embryonic cortex affects the proliferation and number of embryonic cortical precursors.", "Cellular differentiation of embryonic stem cells is accompanied by changes in replication timing, transcription and nuclear localization.", "MeCP2 influences the synaptic maturation of neurons.", "Nuclear transfer from adult human fibroblasts to human oocytes can give rise to blastocysts containing expandable pluripotent cells.", "Alteration of origin firing causes changes in termination zones of Okazaki fragments.", "Activation of the Rac1 homolog CED-10 kills viable cells in SRGP-1 mutant Caenorhabditis elegans.", "The deregulated and prolonged activation of monocytes has deleterious effects in chronic infectious conditions.", "Differentiation of progenitor cells to myeloid cells is skewed upon activation of insulin signaling.", "Differentiation of progenitor cells to myeloid cells is skewed when insulin signaling is suppressed.", "Upregulation of dynein in Drosophila neurons increases the number of microtubule plus-ends growing toward the cell body of each neuron."], "hard_negative": "Acute ablation of Snail in the embryonic cortex affects the proliferation and number of embryonic cortical precursors."}
{"query_id": "82", "query_text": "Addition of BMP4, activin A, CHIR99021, and SU504 to reprogramming fibroblasts generates, expands and maintains cardiovascular progenitor cells (CPCs)", "negative": "Bariatric surgery reduces postmenopausal breast cancer.", "negatives": ["Bariatric surgery reduces postmenopausal breast cancer.", "Patients with panic anxiety show decreased CSF levels of hypocretin.", "Gastric infection with Helicobacter pylori increases risk of gastric cancer in humans.", "The myocardial cell lineage originally develops from cardiac progenitors of exclusively endodermal origin.", "Normal granulomas form in the presence of TNF in Zebrafish.", "Microglia are an innate immune cell type of the central nervous system.", "Taking 400mg of \u03b1-tocopheryl acetate does not prevent prostate cancer.", "Retinoic acid receptor-related orphan receptor gamma (ROR\u03b3) is a therapeutic target for castration-resistant prostate cancer (CRPC)", "Venules have less significant tunica adventitia than arterioles.", "B3-Galectin decreases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR."], "hard_negatives": ["Addition of BMP4, activin A, CHIR99021, and SU504 to reprogramming fibroblasts generates, expands and maintains cardiovascular progenitor cells (CPCs)", "Fibroblast Growth Factor is a ligand which signals through receptor tyrosine kinases.", "Fibroblast growth factor 21 protects against atherosclerosis by modulating adiponectin and SREBP2 levels.", "Cancer-associated fibroblasts (CAFs) interact with cancer cells to mediate formation and activation of CAFs.", "Cancer-associated fibroblasts (CAFs) are constituents of tumor microenvironments", "Cancer-associated fibroblasts (CAFs) have no known interaction with cancer cells in the formation and activation of CAFs.", "Ectopic expression of Sall4, Nanog, Esrrb, and Lin28 generates induced pluripotent stem cells from mouse embryonic fibroblasts more efficiently than other factor combinations.", "The PPR MDA5 has twenty N-terminal CARD domains.", "Pioneer factor OCT3/4 interacts with major chromatin remodeling factors.", "Tirasemtiv targets cardiac muscle."], "hard_negative": "Addition of BMP4, activin A, CHIR99021, and SU504 to reprogramming fibroblasts generates, expands and maintains cardiovascular progenitor cells (CPCs)"}
{"query_id": "85", "query_text": "Adult tissue-resident macrophages are seeded before birth.", "negative": "HNF4A mutations are associated with macrosomia in infancy.", "negatives": ["HNF4A mutations are associated with macrosomia in infancy.", "Enhanced early production of inflammatory chemokines damages viral control in the lung.", "Input from  mental and physical health care professionals is not effective at decreasing homelessness.", "Chenodeoxycholic acid treatment increases brown adipose tissue activity.", "JMJD6 slows the hydroxylation of C-terminal lysine", "Progerin induces premature aging in stem cells.", "Oxidative DNA damage inhibits STING signalling.", "De novo assembly of sequence data has fewer specific contigs than unassembled sequence data.", "Sepsis related mortality has remained stable between 2009-2014.", "NR5A2 does not play a role in development of endometrial tissues."], "hard_negatives": ["Adult tissue-resident macrophages are seeded before birth.", "Adult tissue-resident macrophages are seeded before birth.", "Adult tissue-resident macrophages possess a self-renewing capacity.", "Adult tissue-resident macrophages stem from the embryonal yolk sac and fetal liver.", "Adult tissue-resident macrophages stem from the embryonal yolk sac and fetal liver.", "Bone marrow cells don't contribute to adult macrophage compartments.", "Human embryonic stem cells give rise to cell types from the outer embryonic germ layer, but not the other two layers.", "miRNAs regulate a unique suite of mRNAs to maintain homeostasis in cells.", "Differentiation of progenitor cells to myeloid cells is skewed when insulin signaling is suppressed.", "Differentiation of progenitor cells to myeloid cells is skewed upon activation of insulin signaling."], "hard_negative": "Adult tissue-resident macrophages are seeded before birth."}
{"query_id": "86", "query_text": "Adult tissue-resident macrophages are seeded before birth.", "negative": "Gastric lavage is an effective treatment for acute paraquat poisoning.", "negatives": ["Gastric lavage is an effective treatment for acute paraquat poisoning.", "A low percentage of hematopoietic progenitor cells are susceptible to HIV-1 infection ex vivo.", "Concentrations of SNV and CNV in stem-cell regulatory elements and binding sites of transcription factors in iPSC-lines are distinct from their founding cells.", "Scapular stabilizer exercises are more effective than general exercise therapy in reducing pain and improving function of the shoulder.", "The PPR MDA5 has twenty N-terminal CARD domains.", "Ultrasound guidance significantly reduces the number of needle insertion attempts necessary for a given procedure.", "Acute ablation of KRAS causes severe growth impairment.", "Differentiated E2f-1, -2, -3 TKO cells in the intestine do not exhibit apoptosis.", "The minor G allele of FOXO3 up-regulates IL-10.", "Nonhuman primates are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos."], "hard_negatives": ["Adult tissue-resident macrophages are seeded before birth.", "Adult tissue-resident macrophages are seeded before birth.", "Adult tissue-resident macrophages possess a self-renewing capacity.", "Adult tissue-resident macrophages stem from the embryonal yolk sac and fetal liver.", "Adult tissue-resident macrophages stem from the embryonal yolk sac and fetal liver.", "Bone marrow cells don't contribute to adult macrophage compartments.", "Human embryonic stem cells give rise to cell types from the outer embryonic germ layer, but not the other two layers.", "miRNAs regulate a unique suite of mRNAs to maintain homeostasis in cells.", "Differentiation of progenitor cells to myeloid cells is skewed when insulin signaling is suppressed.", "Differentiation of progenitor cells to myeloid cells is skewed upon activation of insulin signaling."], "hard_negative": "Adult tissue-resident macrophages are seeded before birth."}
{"query_id": "88", "query_text": "Adult tissue-resident macrophages possess a self-renewing capacity.", "negative": "For every 1,000 children with cerebral palsy, more than 300 of them are premature or underweight at birth.", "negatives": ["For every 1,000 children with cerebral palsy, more than 300 of them are premature or underweight at birth.", "Microcin J25 encourages nucleoside triphosphate (NTP) binding.", "Glycan adaptation is rarely observed in the B-cell repertoire.", "Klf4 is not required for proper myeloid cell differentiation.", "Tuberculosis-induced granulomas express different immune system protein signatures than the surrounding tissue.", "Oxidative phosphorylation is one of the primary glycometabolic pathways in cells.", "Up-regulation of the p53 pathway and related molecular events speeds cancer progression.", "Pyridostatin decreases telomere fragility in BRCA2-deficient cells.", "The morphology change from large white adipocytes to small brown adipocytes is a sign of increased energy expenditure potential in white adipose tissue.", "RANK-RANKL pathway signalling is linked to development of Aire-expressing medullary thymic epithelial cells."], "hard_negatives": ["Adult tissue-resident macrophages possess a self-renewing capacity.", "Adult tissue-resident macrophages are seeded before birth.", "Adult tissue-resident macrophages are seeded before birth.", "Adult tissue-resident macrophages stem from the embryonal yolk sac and fetal liver.", "Adult tissue-resident macrophages stem from the embryonal yolk sac and fetal liver.", "Bone marrow cells don't contribute to adult macrophage compartments.", "Cardiac tissue-resident macrophages directly contribute to electrical activity.", "Mitochondria play a major role in energy production.", "0-dimensional biomaterials lack inductive properties.", "The proliferative capacity of progenitors is regulated cell-autonomously."], "hard_negative": "Adult tissue-resident macrophages possess a self-renewing capacity."}
{"query_id": "89", "query_text": "Adult tissue-resident macrophages stem from the embryonal yolk sac and fetal liver.", "negative": "The innate immune response struggles to remove small numbers of parasites.", "negatives": ["The innate immune response struggles to remove small numbers of parasites.", "1-1% of colorectal cancer patients are diagnosed with regional or distant metastases.", "Omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegetarians.", "Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission.", "GATA3 regulates cell cycle progression in bone marrow hematopoietic stem cells.", "Beta-band coherence is diminished for visible stimuli over invisible stimuli.", "Increase of p62 in prostate tumor stroma results in defective autophagy.", "Deletion of ATM and Rad3 related protein leads to acute tissue loss.", "Inhibiting focal adhesion formation enables cells to convert mechanical strain into eventual scarring.", "Charcoal shows no benefit for acute paraquat poisoning."], "hard_negatives": ["Adult tissue-resident macrophages stem from the embryonal yolk sac and fetal liver.", "Adult tissue-resident macrophages stem from the embryonal yolk sac and fetal liver.", "Adult tissue-resident macrophages possess a self-renewing capacity.", "Adult tissue-resident macrophages are seeded before birth.", "Adult tissue-resident macrophages are seeded before birth.", "Bone marrow cells don't contribute to adult macrophage compartments.", "Human embryonic stem cells give rise to cell types from the outer embryonic germ layer, but not the other two layers.", "Human embryonic stem cells give rise to cell types from all three embryonic germ layers.", "Human embryonic stem cells have the capacity to give rise to differentiated progeny representative of all three embryonic germ layers.", "Microglia are an innate immune cell type of the central nervous system."], "hard_negative": "Adult tissue-resident macrophages stem from the embryonal yolk sac and fetal liver."}
{"query_id": "90", "query_text": "Adult tissue-resident macrophages stem from the embryonal yolk sac and fetal liver.", "negative": "Participants who quit smoking reduce lung cancer risk by approximately 50%.", "negatives": ["Participants who quit smoking reduce lung cancer risk by approximately 50%.", "CCL19 is a ligand for CCR7.", "Primary pro-inflammatory cytokines suppress secondary pro- and anti-inflammatory mediators.", "Scapular stabilizer exercises are more effective than general exercise therapy in reducing pain and improving function of the shoulder.", "In rhesus macaques, daily subcutaneous injections of emtricitabine are ineffective at protecting against rectally transmitted simian-human immunodeficiency virus.", "Cancer cells can stimulate the accumulation of intra-tumoural myeloid-derived suppressor cells by promoting granulocyte colony stimulating factor production.", "Sequence conservation in gene regulatory regions between species is a poor predictor of conserved functionality.", "Lamins are associated with nuclear membrane structure maintenance.", "Expression of oncolytic virus antigens as peptides makes relapse more likely.", "The number of unfertilized oocytes in mated hermaphrodites increases with age."], "hard_negatives": ["Adult tissue-resident macrophages stem from the embryonal yolk sac and fetal liver.", "Adult tissue-resident macrophages stem from the embryonal yolk sac and fetal liver.", "Adult tissue-resident macrophages possess a self-renewing capacity.", "Adult tissue-resident macrophages are seeded before birth.", "Adult tissue-resident macrophages are seeded before birth.", "Bone marrow cells don't contribute to adult macrophage compartments.", "Human embryonic stem cells give rise to cell types from the outer embryonic germ layer, but not the other two layers.", "Human embryonic stem cells give rise to cell types from all three embryonic germ layers.", "Human embryonic stem cells have the capacity to give rise to differentiated progeny representative of all three embryonic germ layers.", "Microglia are an innate immune cell type of the central nervous system."], "hard_negative": "Adult tissue-resident macrophages stem from the embryonal yolk sac and fetal liver."}
{"query_id": "91", "query_text": "Aged patients are less susceptible to ischaemia/reperfusion injury.", "negative": "cSMAC formation represses weak ligand signalling.", "negatives": ["cSMAC formation represses weak ligand signalling.", "Activated Cdk5 regulates DNA damage-induced neuronal death.", "M. stadtmanae does not induce ASC speck formation in BlaER1 monocytes.", "Cnn1 recruitment varies with cell cycle timing.", "Intramembrane cleavage by signal peptide peptidase aids in the degradation of proteins with a complex membrane orientation.", "Including pharmacists in rounding teams reduces the incidence of adverse drug events (ADEs).", "IL-6 signaling plays a major role in atherosclerotic cardiovascular disease.", "Cost effectiveness evaluations based on cRCT data lack external validity.", "Bacterial meningitis can be diagnosed on the basis of positive cerebrospinal fluid (CSF) cultures.", "Localization of PIN1 in the roots of Arabidopsis requires VPS9a"], "hard_negatives": ["Aged patients are less susceptible to ischaemia/reperfusion injury.", "Aged patients are more susceptible to ischaemia/reperfusion injury.", "Nonhypertensive people who are 55 years old have a 90% chance of developing hypertension during their lifetime.", "Diabetic patients with acute coronary syndrome experience decreased short-term and long-term risk for bleeding events.", "Treatment with a protein named FN impairs regenerative abilities of aged muscles.", "Risk of cardiovascular events can be cut by a third by using antihypertensive drug therapy among hemodialysis patients.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have increased risk for Alzheimer's disease.", "Physical activity does not improve cognitive function in individuals with Alzheimers.", "In young and middle-aged adults, current or remote uses of ADHD medications increase the risk of serious cardiovascular events.", "Individuals with Alzheimers who participate in six months of physical activity improve cognitive function for up to 18 months."], "hard_negative": "Aged patients are less susceptible to ischaemia/reperfusion injury."}
{"query_id": "92", "query_text": "Aged patients are more susceptible to ischaemia/reperfusion injury.", "negative": "Certain immunomodulator-human dialyzable leukocyte extract (hDLE) peptides are recognized by toll-like receptors (TLRs) on macrophages and dendritic cells.", "negatives": ["Certain immunomodulator-human dialyzable leukocyte extract (hDLE) peptides are recognized by toll-like receptors (TLRs) on macrophages and dendritic cells.", "Bone Marrow (BM) transplantation is used to treat acute myeloid leukemia (AML)", "Kir7.1 modulates channel activity by the G protein-coupled melanocortin-4 receptor (MC4R) in the paraventricular nucleus of the hypothalamus.", "90% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.", "LRBA promotes CTLA - 4 recycling.", "Women with a lower birth weight are more likely to develop breast cancer later in life.", "M. stadtmanae does not induce ASC speck formation in BlaER1 monocytes.", "PKG-la plays an essential role in expression of spinal long term potentiation in PGK-la knockout mice.", "Rising temperatures caused by global warming lowers the risk of dengue fever transmission.", "53% of perinatal mortality is due to low birth weight."], "hard_negatives": ["Aged patients are more susceptible to ischaemia/reperfusion injury.", "Aged patients are less susceptible to ischaemia/reperfusion injury.", "Diabetic patients with acute coronary syndrome experience decreased short-term and long-term risk for bleeding events.", "Nonhypertensive people who are 55 years old have a 90% chance of developing hypertension during their lifetime.", "Treatment with a protein named FN impairs regenerative abilities of aged muscles.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have increased risk for Alzheimer's disease.", "Physical activity does not improve cognitive function in individuals with Alzheimers.", "In young and middle-aged adults, current or remote uses of ADHD medications increase the risk of serious cardiovascular events.", "Risk of cardiovascular events can be cut by a third by using antihypertensive drug therapy among hemodialysis patients.", "Individuals with Alzheimers who participate in six months of physical activity improve cognitive function for up to 18 months."], "hard_negative": "Aged patients are more susceptible to ischaemia/reperfusion injury."}
{"query_id": "93", "query_text": "Aggravated inflammation is dependent on NLRP3 inflammasome activation.", "negative": "Adult tissue-resident macrophages are seeded before birth.", "negatives": ["Adult tissue-resident macrophages are seeded before birth.", "Sn is present on mature DCs during inflammation in vivo.", "Increased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm.", "Amitriptyline is an effective treatment for chronic tension-type headaches.", "Nonhuman primates are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.", "CD28 initiates tonic signaling in conventional T cells, which causes an exhaustion phenotype and limited efficiency.", "The proliferative capacity of neural progenitors differs across species.", "Origin gross domestic product(GDP) is positively related to dengue virus (DENV-1) diffusion in air traffic shipments.", "Binding of p53 to enhancer regions (p53BERs) regulates the activity of p53 transcription and cell cycle arrest through the production of p53-dependent eRNAs.", "The cytokine receptor which regulates chemotaxis and formation of lymph nodes is involved in production of myeloperoxidase in the left atrium."], "hard_negatives": ["Aggravated inflammation is dependent on NLRP3 inflammasome activation.", "PKG-la does not have a large impact on expression of pain hypersensitivity in PGK-la knockout mice.", "PKG-la plays an essential role in expression of spinal long term potentiation in PGK-la knockout mice.", "The NF-\u03baB essential modulator gene induces intestinal inflammation by promoting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death.", "Inhibiting focal adhesion formation increases the rate at which cells convert mechanical strain into inflammation and fibrosis.", "PKG-la does not have a large impact on expression of spinal long term potentiation in PGK-la knockout mice.", "The NF-\u03baB essential modulator gene prevents intestinal inflammation by inhibiting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death.", "Citrullinated proteins externalized in neutrophil extracellular traps act indirectly to perpetuate the inflammatory cycle via induction of autoantibodies.", "Upon viral challenge, influenza-specific memory CD4+ T cells greatly diminish the early production of inflammatory chemokines in the lung.", "Inhibiting focal adhesion formation enables cells to convert mechanical strain into eventual scarring."], "hard_negative": "Aggravated inflammation is dependent on NLRP3 inflammasome activation."}
{"query_id": "95", "query_text": "Albendazole is used to treat soil-transmitted helminths.", "negative": "Long chain polyunsaturated fatty acids supplementation is associated with lower rates of atopic eczema at 1 year.", "negatives": ["Long chain polyunsaturated fatty acids supplementation is associated with lower rates of atopic eczema at 1 year.", "Pioglitazone use is significantly associated with an increased risk of prostate cancer.", "The one-child policy has created a hospitable environment for female infants.", "The DESMOND program caused substantial weight loss in most participants.", "ATM and Rad3 related protein are critical for sensing DNA damage.", "Diabetic patients with acute coronary syndrome experience decreased short-term and long-term risk for bleeding events.", "Perigenital skin is not the primary site of HIV acquisition.", "Rapamycin delays aging in fruit flies.", "Patients in stable partnerships progress from HIV to death at the same rate as patients not in partnerships.", "APOE4 expression in iPSC-derived neurons results in decreased tau phosphorylation."], "hard_negatives": ["Albendazole is used to treat soil-transmitted helminths.", "Helminths interfere with immune system control of coinfections by microbial pathogens 16.", "Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission.", "Eilat virus (EILV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in nonhuman primates.", "Antimicrobial agents are less effective due to the pressure of antimicrobial usage.", "Anthrax spores are very difficult to dispose once they are dispersed.", "The DdrB protein from Deinococcus radiodurans functions as a pentamer.", "Anthrax spores remain deadly until affected areas are decontaminated.", "Antimicrobial agents are more effective due to the pressure of antimicrobial usage.", "Urbanization is an important risk factor related to the transmission of dengue fever."], "hard_negative": "Albendazole is used to treat soil-transmitted helminths."}
{"query_id": "96", "query_text": "Algerian physicians constitue the largest component of sub-Saharan Africa-trained physicians in the United States.", "negative": "Upregulation of PD1 causes the upregulation of Satb1.", "negatives": ["Upregulation of PD1 causes the upregulation of Satb1.", "Beta-band coherence is diminished for visible stimuli over invisible stimuli.", "Mutant mice lacking SVCT2 have severely reduced ascorbic acid levels in both brain and adrenals.", "The effect of Lipopolysaccharides on kidney barrier function is dependent on inflammation levels.", "Bariatric surgery reduces colorectal cancer.", "Patients with microcytosis and higher erythrocyte count were more resistant to severe malarial anaemia when infected with Plasmodium falciparum.", "50% of patients exposed to radiation have activated markers of mesenchymal stem cells.", "DMS3 protein enables Pol V transcription in vivo.", "MafA ubiquitination decreases the recruitment of coavtivator P/CAF by MafA.", "p16INK4A degradation is encoded by CDKN2A."], "hard_negatives": ["Algerian physicians constitue the largest component of sub-Saharan Africa-trained physicians in the United States.", "Nigerian physicians constitue the largest component of sub-Saharan Africa-trained physicians in the United States.", "Students who perform poorly in the early years of medical school are less likely to commit professional misconduct later in their careers.", "Students who perform poorly in the early years of medical school are at increased risk for professional misconduct later in their careers.", "Risk-adjusted mortality rates are similar in teaching and non-teaching hospitals.", "76-85% of people with severe mental disorder receive no treatment in low and middle income countries.", "The World Health Organization's (WHO) data collection process is biased downward by unequal selection of larger outbreaks.", "Malaria has a high vectorial capacity.", "70% of burn patients are admitted for hospitalization and further treatment after appearing at hospital emergency wards or outpatient clinics.", "Tuberculosis incidence occurs at higher rates in more sparsely populated areas in the UK."], "hard_negative": "Algerian physicians constitue the largest component of sub-Saharan Africa-trained physicians in the United States."}
{"query_id": "98", "query_text": "Alirocumab treatment reduces apo(a) fractional clearance rate.", "negative": "Prescribed exercise training improves quality of life.", "negatives": ["Prescribed exercise training improves quality of life.", "Omnivores produce less trimethylamine N-oxide from dietary I-carnitine than vegans.", "The predominant localization of Linc00173 is in mononuclear macrophage nuclei.", "Human embryonic stem cells give rise to cell types from the outer embryonic germ layer, but not the other two layers.", "Sympathetic nerve activity is elevated throughout normal pregnancy.", "One in five surgical randomized controlled trials are discontinued early.", "Pioglitazone use is significantly associated with an increased risk of pancreatic cancer.", "The risk of female prisoners harming themselves is ten times that of male prisoners.", "Metastatic colorectal cancer treated with a single agent fluoropyrimidines resulted in similar efficacy and better quality of life when compared with oxaliplatin-based chemotherapy in elderly patients.", "Bariatric surgery reduces postmenopausal breast cancer."], "hard_negatives": ["Alirocumab treatment reduces apo(a) fractional clearance rate.", "AZT given with ribavirin increases anemia.", "Taking anti-depresents is associated with a decrease in the A\u03b2 level in the brain of experimental animals.", "MafA ubiquitination decreases the recruitment of coavtivator P/CAF by MafA.", "The most prevalent adverse events to Semaglutide are gastrointestinal.", "MafA ubiquitination increases the recruitment of coavtivator P/CAF by MafA.", "Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission.", "The most prevalent adverse events to Semaglutide are cardiovascular.", "A 100g dose of chloroquine chemoprophylactic regimen results in retinal toxicity after 1 year of weekly intake.", "Treatment with the EC uptake inhibitor AM404 resulted in a dose-dependent decrease in the expression of immobility."], "hard_negative": "Alirocumab treatment reduces apo(a) fractional clearance rate."}
{"query_id": "104", "query_text": "Allogeneic mechanical circulatory support is not as effective as autologous mechanical circulatory support for treating acute myocardial infarction.", "negative": "At least 85% of patients exposed to radiation have activated markers of myofibroblasts.", "negatives": ["At least 85% of patients exposed to radiation have activated markers of myofibroblasts.", "HOXB4 is a highly expressed component of cellular secretome from fetal liver cell populations.", "The first MBT repeat of the four malignant brain tumor (4MBT) domain of Drosophila's Sfmbt and of the orthologous mammalian L3MBTL2 is required for the interaction with the spacer region of Drosophila's Pleiohomeotic (Pho) or its human ortholog YY1.", "Foxk2 regulates autophagy genes in muscle cells and fibroblast cells.", "Insulin decreases risk of severe kidney failure.", "PGE 2 suppresss intestinal tumor growth by altering the expression of tumor suppressing and DNA repair genes.", "Assessing treatment adherence is more beneficial to clinical practice than measuring routine outcomes.", "Mutations in G-Beta protein GNB1 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.", "Mice without IFN-\u03b3 or its receptor are highly susceptible to EAM induced with \u03b1-MyHC/CFA.", "Patients with common epithelial cancers  are more likely to have an emergency event as their first hospital admission if they live in resource-deprived areas."], "hard_negatives": ["Allogeneic mechanical circulatory support is not as effective as autologous mechanical circulatory support for treating acute myocardial infarction.", "Noninvasive positive pressure ventilation is not predictive of acute respiratory failure after solid organ transplantation.", "Sudden death can occur in patients with complex ventricular arrhythmias.", "Sudden death can occur in patients with orthostatic hypertension without cardiac conduction abnormalities.", "The myocardial cell lineage originally develops from cardiac progenitors of exclusively endodermal origin.", "Stroke patients with prior use of direct oral anticoagulants have a higher risk of in-hospital mortality than stroke patients with prior use of warfarin.", "Osteoparthritis (OA) is characterized by degeneration of articular cartilage, joint edge, and subchondral bone hyperplasia.", "Inhibiting focal adhesion formation increases the rate at which cells convert mechanical strain into inflammation and fibrosis.", "Surgical treatment is not superior to non-surgical in treating adults with displaced fractures of the proximal humerus.", "CRP is positively correlated with postoperative mortality following Coronary Artery Bypass Graft (CABG) surgery."], "hard_negative": "Allogeneic mechanical circulatory support is not as effective as autologous mechanical circulatory support for treating acute myocardial infarction."}
{"query_id": "105", "query_text": "Alteration of origin firing causes changes in termination zones of Okazaki fragments.", "negative": "PCSK9 inhibitors decrease plasma Lp(a) levels.", "negatives": ["PCSK9 inhibitors decrease plasma Lp(a) levels.", "Forkhead 0 (fox0) transcription factors are involved in cellular differentiation.", "Osteocytes have an essential role in G-CSF induced HSPC mobilization.", "Klf2 is important for proper myeloid cell function.", "Kir7.1 modulates channel activity by the G protein-coupled melanocortin-4 receptor (MC4R) in the paraventricular nucleus of the hypothalamus.", "miR-142-5P is a temperature-sensitive microRNA (miRNA).", "A country's Vaccine Alliance (GAVI) eligibility is not indictivate of accelerated adoption of the Hub vaccine.", "Oxidative DNA damage activates STING signalling.", "Immune complex triggered cell death leads to sequestration of oxidized mitochondrial DNA.", "Cyclin A2 destruction is necessary to switch from unstable to stable kt-mt attachments in mitosis."], "hard_negatives": ["Alteration of origin firing causes changes in termination zones of Okazaki fragments.", "Most termination events in Okazaki fragments are dictated by initiation patterns.", "Cyclin A2 destruction is necessary to switch from unstable to stable kt-mt attachments in mitosis.", "Acute ablation of Snail in the embryonic cortex affects the proliferation and number of embryonic cortical precursors.", "Inhibiting focal adhesion formation enables cells to convert mechanical strain into eventual scarring.", "Immune complex triggered cell death leads to extracellular release of nuclear DNA.", "Cellular clocks are associated with mitosis timing in NIH 3T3 cells.", "Cellular clocks are not predictive of mitosis timing in NIH 3T3 cells.", "Recognition of start codons depends on the translation initiation factor IF3.", "Pyridostatin encourages proliferation of homologous recombination - defective cells."], "hard_negative": "Alteration of origin firing causes changes in termination zones of Okazaki fragments."}
{"query_id": "106", "query_text": "Ambulatory blood pressure monitoring is inaccurate at diagnosing hypertension.", "negative": "BLM gene encodes RecQ-class DNA helicase.", "negatives": ["BLM gene encodes RecQ-class DNA helicase.", "Antidepressants increase the severity of migraines.", "Expression of MSX2 is induced 3 hours after the addition of BMP4, which is earlier than T and CDX2.", "RUNX is not expressed in skin tissue.", "Egr2 regulates the homeostasis of B and T cells.", "Adult tissue-resident macrophages stem from the embryonal yolk sac and fetal liver.", "Incidence of 10/66 dementia is lower than the incidence of DSM-IV dementia.", "A single nucleotide variant the gene DGKK is strongly associated with increased risk of hypospadias.", "A country's Vaccine Alliance (GAVI) eligibility is not indictivate of accelerated adoption of the Hub vaccine.", "Treatment with a protein named FN restores regenerative abilities of aged muscles."], "hard_negatives": ["Ambulatory blood pressure monitoring is inaccurate at diagnosing hypertension.", "Decreased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm.", "Increased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm.", "Sudden death can occur in patients with orthostatic hypertension without cardiac conduction abnormalities.", "Nonhypertensive people who are 55 years old have a 90% chance of developing hypertension during their lifetime.", "Noninvasive positive pressure ventilation is not predictive of acute respiratory failure after solid organ transplantation.", "Insulin decreases risk of severe kidney failure.", "Risk of cardiovascular events can be cut by a third by using antihypertensive drug therapy among hemodialysis patients.", "CRP is positively correlated with postoperative mortality following Coronary Artery Bypass Graft (CABG) surgery.", "Diabetic patients with acute coronary syndrome experience decreased short-term and long-term risk for bleeding events."], "hard_negative": "Ambulatory blood pressure monitoring is inaccurate at diagnosing hypertension."}
{"query_id": "108", "query_text": "Amitriptyline is an effective treatment for chronic tension-type headaches.", "negative": "Allogeneic mechanical circulatory support is not as effective as autologous mechanical circulatory support for treating acute myocardial infarction.", "negatives": ["Allogeneic mechanical circulatory support is not as effective as autologous mechanical circulatory support for treating acute myocardial infarction.", "Cytosolic proteins bind to iron-responsive elements on mRNAs coding for TFRC1.", "The cytokine receptor which regulates chemotaxis and formation of lymph nodes is involved in production of myeloperoxidase in the left atrium.", "Replacement of OCT4 and SOX2 genes with GATA3 has the ability to reprogram human cells.", "Incidence of sepsis has fallen substantially from 2009 to 2014.", "A single nucleotide variant the gene DGKK is strongly associated with increased risk of hypospadias.", "Intake of folic acid (FA) and vitamin B6 (VB6) increases levels of homocysteine.", "The World Health Organization's (WHO) data collection process is biased downward by unequal selection of larger outbreaks.", "During the primary early antibody response activated B cells migrate toward the inner-and outer follicular areas where oxysterol accumulation is generated by stromal cells.", "90% of patients with melanoma and an objective response to PD-1 blockade will experience a progression in their melanoma."], "hard_negatives": ["Amitriptyline is an effective treatment for chronic tension-type headaches.", "Antidepressants reduce the severity of migraines.", "Antidepressants increase the severity of migraines.", "Sildenafil worsens erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.", "Side effects associated with antidepressants increases risk of stroke.", "Side effects associated with antidepressants do not represent a mortality risk to postmenopausal women.", "Pioglitazone use is significantly associated with an increased risk of prostate cancer.", "Cognitive behavioral therapy is an ineffective treatment for insomnia", "Pioglitazone use is not associated with an increased risk of prostate cancer.", "Varenicline monotherapy is more effective after 26 weeks of treatment compared to combination nicotine replacement therapies with varenicline or bupropion."], "hard_negative": "Amitriptyline is an effective treatment for chronic tension-type headaches."}
{"query_id": "109", "query_text": "An M2-like phenotype in brown adipose tissue macrophages is quickly induced by cold exposure.", "negative": "Taking 400mg of \u03b1-tocopheryl acetate does not prevent prostate cancer.", "negatives": ["Taking 400mg of \u03b1-tocopheryl acetate does not prevent prostate cancer.", "A diminished ovarian reserve is a very strong indicator of infertility, even in an a priori non-infertile population.", "YAP/TAZ is required in intestinal regeneration in mouse models of ulcerative colitis.", "Diabetes remission occurs more in people treated with conventional therapy than in people treated with laparoscopic adjustable gastric banding surgery.", "The first MBT repeat of the four malignant brain tumor (4MBT) domain of Drosophila's Sfmbt and of the orthologous mammalian L3MBTL2 is required for the interaction with the spacer region of Drosophila's Pleiohomeotic (Pho) or its human ortholog YY1.", "Side effects associated with antidepressants increases risk of stroke.", "Removal of H3K9me3 by ectopic expression of other H3K9 demethylases decreases reprogramming efficiency in SCNT experiments.", "A deficiency of folate increases blood levels of homocysteine.", "Toll-like receptor (TLR) signaling is involved in the pathogenesis of human MDS.", "Anthrax spores remain deadly until affected areas are decontaminated."], "hard_negatives": ["An M2-like phenotype in brown adipose tissue macrophages is quickly induced by cold exposure.", "The M2-phenotype in brown adipose tissue macrophages increases brown adipose tissue thermogenic activity.", "The morphology change from large white adipocytes to small brown adipocytes is a sign of decreased energy expenditure potential in white adipose tissue.", "The morphology change from large white adipocytes to small brown adipocytes is a sign of increased energy expenditure potential in white adipose tissue.", "Chenodeoxycholic acid treatment decreases brown adipose tissue activity.", "Chenodeoxycholic acid treatment increases brown adipose tissue activity.", "Ca2+ cycling controls whole-body energy homeostasis in beige fat.", "Ethanol stress reduces the expression of SRL in bacteria.", "Ethanol stress increases the expression of SRL in bacteria.", "aPKCz causes tumour suppression by affecting glutamine metabolism."], "hard_negative": "An M2-like phenotype in brown adipose tissue macrophages is quickly induced by cold exposure."}
{"query_id": "111", "query_text": "Androgenetic haploid mouse embryonic stem cells (ESCs) can be derived and genetically manipulated in vitro.", "negative": "Mice defective for deoxyribonucleic acid (DNA) polymerase I (polI) fail to reveal increased sensitivity to ionizing radiation (IR).", "negatives": ["Mice defective for deoxyribonucleic acid (DNA) polymerase I (polI) fail to reveal increased sensitivity to ionizing radiation (IR).", "Female carriers of the Apolipoprotein E4 (APOE4) allele have increased risk for Alzheimer's disease.", "Certain immunomodulator-human dialyzable leukocyte extract (hDLE) peptides are recognized by toll-like receptors (TLRs) on macrophages and dendritic cells.", "The artifactual C-terminal helix swapping in the StART domain is observed in the Ups1-Mdm35 heterodimer of the StARkin superfamily.", "B3-Galectin increases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR.", "ScPif1p has reduced binding ability to G-rich ssDNA compared to non-G-rich ssDNA.", "qSOFA scores are associated with length of stay in emergency department patients.", "Vitamin D is an important factor in the relationship between calcium and parathyroid hormone.", "Varenicline monotherapy is more effective after 26 weeks of treatment compared to combination nicotine replacement therapies with varenicline or bupropion.", "Origin gross domestic product(GDP) is positively related to dengue virus (DENV-1) diffusion in air traffic shipments."], "hard_negatives": ["Androgenetic haploid mouse embryonic stem cells (ESCs) can be derived and genetically manipulated in vitro.", "Human embryonic stem cells have the capacity to give rise to differentiated progeny representative of all three embryonic germ layers.", "Human embryonic stem cells give rise to cell types from all three embryonic germ layers.", "Human embryonic stem cells give rise to cell types from the outer embryonic germ layer, but not the other two layers.", "Mouse models can be generated using \"artificial spermatids.\"", "Specialized functional cell types can be derived from human pluripotent stem cells.", "Cellular differentiation of embryonic stem cells is accompanied by changes in replication timing, transcription and nuclear localization.", "Transplanted human glial progenitor cells can mature in their host animal.", "In pediatric tissue, most T cells are naive T cell emigrants from the thymus.", "Induced hepatic stem cells possess the potential to differentiate into cholangiocytic cells."], "hard_negative": "Androgenetic haploid mouse embryonic stem cells (ESCs) can be derived and genetically manipulated in vitro."}
{"query_id": "112", "query_text": "Angiotensin converting enzyme inhibitors are associated with decreased risk for functional renal insufficiency.", "negative": "The innate immune response struggles to remove small numbers of parasites.", "negatives": ["The innate immune response struggles to remove small numbers of parasites.", "Approximately 250,000 people are infected with human T-cell lymphotropic virus type 1 in the United Kingdom.", "YAP/TAZ is required in intestinal regeneration in mouse models of ulcerative colitis.", "Deletion of ATM and Rad3 related protein leads to acute tissue loss.", "Rapamycin delays aging in fruit flies.", "Pediatric SCD patients with vaso-occlusive crisis show increased morphine use after breathing 80 ppm iNO for 4 hours.", "British male students are bullied more than British female students.", "GATA3 regulates cell cycle progression in bone marrow hematopoietic stem cells.", "N348I mutations cause resistance to nevirapine.", "JMJD6 slows the hydroxylation of C-terminal lysine"], "hard_negatives": ["Angiotensin converting enzyme inhibitors are associated with decreased risk for functional renal insufficiency.", "NAC destabilizes NO to increase the effect of contrast agents on renal functions.", "40mg/day dosage of folic acid and 2mg/day dosage of vitamin B12 does not affect chronic kidney disease (CKD) progression.", "The effect of Lipopolysaccharides on kidney barrier function is dependent on inflammation levels.", "NAC inhibits the generation of angiotensin-converting enzyme.", "Insulin decreases risk of severe kidney failure.", "Autophagy deficiency in the liver increases vulnerability to insulin resistance.", "A deficiency of folate increases blood levels of homocysteine.", "A deficiency of vitamin B12 decreases blood levels of homocysteine.", "Lipopolysaccharides have an inflammation independent effect on kidney barrier function."], "hard_negative": "Angiotensin converting enzyme inhibitors are associated with decreased risk for functional renal insufficiency."}
{"query_id": "114", "query_text": "Anthrax spores are very difficult to dispose once they are dispersed.", "negative": "Cellular clocks are associated with mitosis timing in NIH 3T3 cells.", "negatives": ["Cellular clocks are associated with mitosis timing in NIH 3T3 cells.", "Aged patients are more susceptible to ischaemia/reperfusion injury.", "Diabetes remission occurs less in people treated with conventional therapy than in people treated with laparoscopic adjustable gastric banding surgery.", "PKG-la does not have a large impact on expression of pain hypersensitivity in PGK-la knockout mice.", "Androgenetic haploid mouse embryonic stem cells (ESCs) can be derived and genetically manipulated in vitro.", "Cellular differentiation of embryonic stem cells is accompanied by changes in replication timing, transcription and nuclear localization.", "Ly49Q directs the organization of neutrophil polarization by regulating membrane raft functions.", "The innate immune response struggles to remove small numbers of parasites.", "V-9302 inhibits antitumor responses by decreasing cell death and oxidative stress.", "Normal expression of RUNX1 causes tumorsupressing effects."], "hard_negatives": ["Anthrax spores are very difficult to dispose once they are dispersed.", "Anthrax spores remain deadly until affected areas are decontaminated.", "Tuberculosis-induced granulomas express different immune system protein signatures than the surrounding tissue.", "The tissue surrounding the granuloma in an immune cell induces an anti-inflammatory immune response.", "Inside the body, falciparum parasites reproduce asexually.", "Nonhuman primates are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.", "Eilat virus (EILV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in nonhuman primates.", "A low percentage of hematopoietic progenitor cells are susceptible to HIV-1 infection ex vivo.", "Charcoal is an effective treatment for acute paraquat poisoning.", "Gastric infection with Helicobacter pylori decreases risk of gastric cancer in humans."], "hard_negative": "Anthrax spores are very difficult to dispose once they are dispersed."}
{"query_id": "116", "query_text": "Anthrax spores remain deadly until affected areas are decontaminated.", "negative": "RA activation of DIF2 and NB4 cells induces hallmarks of transcriptionally active promoters.", "negatives": ["RA activation of DIF2 and NB4 cells induces hallmarks of transcriptionally active promoters.", "Pyridostatin induces checkpoint activation.", "Helicobacter pylori-induced aberrant NF-kB-dependent expression of activation-induced cytidine deaminase contributes to the mutagenesis of host DNA.", "Omnivores produce less trimethylamine N-oxide from dietary I-carnitine than vegans.", "Post-transcriptional handling of mitochondrial transcripts occurs in mitochondrial RNA granules.", "Low expression of miR7a does not repress target genes or exert a biological function in testis.", "The amount of publicly available DNA data doubles every 10 months.", "Genomic sequences involved in alternative splicing responsible for Hutchinson-Gilford progeria syndrome (HGPS) are abundant in the ''progerinonly'' allele of Lmna knock-in models.", "MFGE8 regulates fat absorption by binding to av-Beta3 and av-Beta5 integrins.", "Ethanol stress reduces the expression of SRL in bacteria."], "hard_negatives": ["Anthrax spores remain deadly until affected areas are decontaminated.", "Anthrax spores are very difficult to dispose once they are dispersed.", "Eilat virus (EILV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in nonhuman primates.", "Charcoal is an effective treatment for acute paraquat poisoning.", "Nonhuman primates are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.", "Rising temperatures caused by global warming lowers the risk of dengue fever transmission.", "Rising temperatures caused by global warming increases risk of dengue fever transmission.", "Urbanization is an important risk factor related to the transmission of dengue fever.", "The innate immune response struggles to remove small numbers of parasites.", "Charcoal shows no benefit for acute paraquat poisoning."], "hard_negative": "Anthrax spores remain deadly until affected areas are decontaminated."}
{"query_id": "119", "query_text": "Antidepressants increase the severity of migraines.", "negative": "For every 1,000 children with cerebral palsy, more than 300 of them are premature or underweight at birth.", "negatives": ["For every 1,000 children with cerebral palsy, more than 300 of them are premature or underweight at birth.", "Surgical treatment is not superior to non-surgical in treating adults with displaced fractures of the proximal humerus.", "Lack of FGF21 in mice leads to reduced lifespan.", "A deficiency of folate increases blood levels of homocysteine.", "Enhanced early production of inflammatory chemokines damages viral control in the lung.", "Incidence of sepsis has fallen substantially from 2009 to 2014.", "The ability of activator E2Fs in preventing cell death is limited to terminally differentiated cells.", "The PDPN gene deactivates the C-type lectin receptor (CLEC-2).", "Cognitive behavioral therapy is an ineffective treatment for insomnia", "Binding of p53 to enhancer regions (p53BERs) regulates the activity of p53 transcription and cell cycle arrest through the production of p53-dependent eRNAs."], "hard_negatives": ["Antidepressants increase the severity of migraines.", "Antidepressants reduce the severity of migraines.", "Side effects associated with antidepressants increases risk of stroke.", "Side effects associated with antidepressants do not represent a mortality risk to postmenopausal women.", "Sildenafil worsens erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.", "Side effects associated with antidepressants lower risk of myocardial infarction.", "Headaches are correlated with cognitive impairment.", "Amitriptyline is an effective treatment for chronic tension-type headaches.", "Patients with panic anxiety show decreased CSF levels of hypocretin.", "In young and middle-aged adults, current or remote uses of ADHD medications increase the risk of serious cardiovascular events."], "hard_negative": "Antidepressants increase the severity of migraines."}
{"query_id": "120", "query_text": "Antidepressants reduce the severity of migraines.", "negative": "Flexible molecules experience less steric hindrance in the tumor microenviroment than rigid molecules.", "negatives": ["Flexible molecules experience less steric hindrance in the tumor microenviroment than rigid molecules.", "Microcin J25 inhibits nucleoside triphosphate (NTP) binding.", "Patients with microcytosis and higher erythrocyte count are more vulnerable to severe malarial anaemia when infected with Plasmodium falciparum.", "Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes fibrosis.", "A diminished ovarian reserve does not solely indicate infertility in an a priori non-infertile population.", "Aged patients are less susceptible to ischaemia/reperfusion injury.", "Allogeneic mechanical circulatory support is not as effective as autologous mechanical circulatory support for treating acute myocardial infarction.", "Toll-like receptor (TLR) signaling is involved in the pathogenesis of human MDS.", "There was an estimated 30 million cases of pneumonia in young children worldwide in 2010.", "cSMAC formation represses weak ligand signalling."], "hard_negatives": ["Antidepressants reduce the severity of migraines.", "Antidepressants increase the severity of migraines.", "Side effects associated with antidepressants increases risk of stroke.", "Side effects associated with antidepressants do not represent a mortality risk to postmenopausal women.", "Sildenafil worsens erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.", "Side effects associated with antidepressants lower risk of myocardial infarction.", "Amitriptyline is an effective treatment for chronic tension-type headaches.", "Headaches are correlated with cognitive impairment.", "Patients with panic anxiety show decreased CSF levels of hypocretin.", "In young and middle-aged adults, current or remote uses of ADHD medications increase the risk of serious cardiovascular events."], "hard_negative": "Antidepressants reduce the severity of migraines."}
{"query_id": "121", "query_text": "Antimicrobial agents are less effective due to the pressure of antimicrobial usage.", "negative": "Genetic deficiency of mast cells leads to decreased weight gain in a mouse model of diet-induced obesity.", "negatives": ["Genetic deficiency of mast cells leads to decreased weight gain in a mouse model of diet-induced obesity.", "The composition of myosin-II isoform switches from the A isoform to the B isoform during hematopoietic differentiation.", "Ambulatory blood pressure monitoring is inaccurate at diagnosing hypertension.", "The peak incidence of fractures occurs during pubertal growth spurt in early adolescents.", "Basophils promote disease development in patients with systemic lupus erythematosus (SLE).", "PCSK9 inhibitors decrease plasma Lp(a) levels.", "The proportion of people with visual difficulty is two times higher in low-income countries than in high-income countries.", "50% of patients exposed to radiation have activated markers of mesenchymal stem cells.", "Sn is present on mature DCs during inflammation in vivo.", "HOXB4 facilitates HSC expansion when co-cultured with HSCs."], "hard_negatives": ["Antimicrobial agents are less effective due to the pressure of antimicrobial usage.", "Antimicrobial agents are more effective due to the pressure of antimicrobial usage.", "Increased flux of microbial products provokes immune responses.", "Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission.", "Increased flux of microbial products suppresses immune responses.", "The most prevalent adverse events to Semaglutide are cardiovascular.", "The most prevalent adverse events to Semaglutide are gastrointestinal.", "Systemic immunosuppressive (IS) therapy increases the chance of cancer mortality in patients with inflammatory eye disease (IED)", "Side effects associated with antidepressants increases risk of stroke.", "Systemic immunosuppressive (IS) therapy does not enhance the chance of cancer mortality in patients with inflammatory eye disease (IED)"], "hard_negative": "Antimicrobial agents are less effective due to the pressure of antimicrobial usage."}
{"query_id": "122", "query_text": "Antimicrobial agents are more effective due to the pressure of antimicrobial usage.", "negative": "32% of liver transplantation programs required patients to discontinue methadone treatment in 2001.", "negatives": ["32% of liver transplantation programs required patients to discontinue methadone treatment in 2001.", "Ly49Q directs the organization of neutrophil polarization by regulating membrane raft functions.", "Cancers that initially benefit from epidermal growth factor receptor targeted therapies later become refractory through several mechanisms.", "A single nucleotide variant the gene DGKK is strongly associated with increased risk of hypospadias.", "LRBA prevents CTLA - 4 recycling.", "The ability of activator E2Fs in preventing cell death is limited to terminally differentiated cells.", "Environmental factors can influence the development of breast cancer.", "Insulin decreases risk of severe kidney failure.", "Commelina yellow mottle virus' (ComYMV) genome consists of 2140 baise pairs.", "FoxO3a activation in neuronal death is inhibited by reactive oxygen species (ROS)."], "hard_negatives": ["Antimicrobial agents are more effective due to the pressure of antimicrobial usage.", "Antimicrobial agents are less effective due to the pressure of antimicrobial usage.", "Increased flux of microbial products provokes immune responses.", "Increased flux of microbial products suppresses immune responses.", "Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission.", "The most prevalent adverse events to Semaglutide are cardiovascular.", "The most prevalent adverse events to Semaglutide are gastrointestinal.", "Systemic immunosuppressive (IS) therapy increases the chance of cancer mortality in patients with inflammatory eye disease (IED)", "Side effects associated with antidepressants increases risk of stroke.", "Systemic immunosuppressive (IS) therapy does not enhance the chance of cancer mortality in patients with inflammatory eye disease (IED)"], "hard_negative": "Antimicrobial agents are more effective due to the pressure of antimicrobial usage."}
{"query_id": "123", "query_text": "Antiretroviral therapy increases rates of tuberculosis across a broad range of CD4 strata.", "negative": "Primary cervical cytology screening with HPV detection has higher longitudinal sensitivity to detect severe cervical intraepithelial neoplasia than conventional cytology.", "negatives": ["Primary cervical cytology screening with HPV detection has higher longitudinal sensitivity to detect severe cervical intraepithelial neoplasia than conventional cytology.", "IL-6 signaling plays a major role in atherosclerotic cardiovascular disease.", "Repressing IL-18 has negative effects on atherosclerotic lesion composition and progression.", "mcm 5 s 2 U is required for proper decoding of NNR codons in eukaryotes.", "VgrG (Tssl) protein punctures membranes by forming a spike at the tip of the tube apparatus.", "Long chain polyunsaturated fatty acids supplementation is associated with lower rates of atopic eczema at 1 year.", "Roughly 55% of women with chronic pelvic pain have no underlying pathology.", "Comparative transcriptome analysis identified new platelet proteins with structural features suggesting a role in platelet function.", "Chronic HIV stimulation of B cells leads to the premature exhaustion of B cells.", "BCL-2 activation antagonizes the apoptotic effects of c-Myc."], "hard_negatives": ["Antiretroviral therapy increases rates of tuberculosis across a broad range of CD4 strata.", "Tuberculosis incidence occurs at higher rates in more sparsely populated areas in the UK.", "Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission.", "Tuberculosis-induced granulomas express different immune system protein signatures than the surrounding tissue.", "Chronic HIV stimulation of B cells leads to the premature exhaustion of B cells.", "Side effects associated with antidepressants increases risk of stroke.", "Exhaustion of B cells contributes to poor Ab response in HIV-infected individuals.", "Taking anti-depresents is associated with a decrease in the A\u03b2 level in the brain of experimental animals.", "Antidepressants reduce the severity of migraines.", "In patients with congenital heart defects, \u03b2-blockers significantly improve clinical heart failure outcomes."], "hard_negative": "Antiretroviral therapy increases rates of tuberculosis across a broad range of CD4 strata."}
{"query_id": "126", "query_text": "Approximately 250,000 people are infected with human T-cell lymphotropic virus type 1 in the United Kingdom.", "negative": "Reduced levels of lipolysis leads to higher P38 phosphorylation in adipose tissue.", "negatives": ["Reduced levels of lipolysis leads to higher P38 phosphorylation in adipose tissue.", "The deregulated and prolonged activation of monocytes has deleterious effects in chronic infectious conditions.", "Bacteriophagaes MS2 and Q\u03b2 are members of the Leviviridae.", "Systemic lupus erythematosus is a risk factor for cardiovascular disease.", "Homozygous deletion of murine Sbds gene from osterix-expressing mesenchymal stem and progenitor cells (MPCs) induces oxidative stress.", "Fibroblast Growth Factor is a ligand which signals through receptor tyrosine kinases.", "Ethanol stress increases the expression of SRL in bacteria.", "Expression of oncolytic virus antigens as peptides permits additional protection against relapse.", "Glycan adaptation is rarely observed in the B-cell repertoire.", "Long - range chromatin interactions regulate transcription."], "hard_negatives": ["Approximately 250,000 people are infected with human T-cell lymphotropic virus type 1 in the United Kingdom.", "In pediatric tissue, most T cells are naive T cell emigrants from the thymus.", "There was an estimated 30 million cases of pneumonia in young children worldwide in 2010.", "Tuberculosis incidence occurs at higher rates in more sparsely populated areas in the UK.", "Ten percent (10%) of kidney cancers in the UK are attributable to excess weight.", "Eilat virus (EILV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in nonhuman primates.", "The latent infection of myeloid cells with human cytomegalovirus induces a number of changes in gene expression.", "A low percentage of hematopoietic progenitor cells are susceptible to HIV-1 infection ex vivo.", "A T helper 2 cell (Th2) environment impedes disease development in patients with systemic lupus erythematosus (SLE).", "Bone Marrow (BM) transplantation is used to treat acute myeloid leukemia (AML)"], "hard_negative": "Approximately 250,000 people are infected with human T-cell lymphotropic virus type 1 in the United Kingdom."}
{"query_id": "134", "query_text": "Assessing treatment adherence is more beneficial to clinical practice than measuring routine outcomes.", "negative": "In transgenic mice harboring green florescent protein under the control of the Sox2 promoter, more than 50 percent of the cells with green florescent colocalize with cell proliferation markers.", "negatives": ["In transgenic mice harboring green florescent protein under the control of the Sox2 promoter, more than 50 percent of the cells with green florescent colocalize with cell proliferation markers.", "Distant CREs are less conserved among species.", "1-1% of colorectal cancer patients are diagnosed with regional or distant metastases.", "1-1% of colorectal cancer patients are diagnosed with regional or distant metastases.", "EG7 tumors can be killed by systemic oxaliplatin primed CD8+ T cells from the tumor-draining lymph node cells.", "Rising temperatures caused by global warming increases risk of dengue fever transmission.", "Early patent ductus ateriosus (PDA) screening decreases in-hospital mortality.", "The risk of cancer rises with level of alcohol consumption.", "The combination of physical examinations with C-reactive protein values do not improve the accuracy of radiographic verified pneumonia predictions.", "MafA ubiquitination increases the recruitment of coavtivator P/CAF by MafA."], "hard_negatives": ["Assessing treatment adherence is more beneficial to clinical practice than measuring routine outcomes.", "Measuring routine outcomes is more beneficial to clinical practice than assessing treatment adherence.", "Cost effectiveness evaluations based on cRCT data accurately reflect prices for patients in actual clinical practice.", "Misunderstandings between doctors and patients can lead to non-adherence.", "Including pharmacists in rounding teams does not alter the incidence of adverse drug events (ADEs).", "Including pharmacists in rounding teams reduces the incidence of adverse drug events (ADEs).", "Cost effectiveness evaluations based on cRCT data lack external validity.", "Integrated care is ineffective at tackling multiple comorbidities.", "Integrated care is successful at tackling multiple comorbidities.", "Therapeutics receiving accelerated approval encounter a lower frequency of post-marketing safety events"], "hard_negative": "Assessing treatment adherence is more beneficial to clinical practice than measuring routine outcomes."}
{"query_id": "138", "query_text": "Asymptomatic visual impairment screening in elderly populations leads to improved vision.", "negative": "The gene daf-16, which encodes forkhead Box O (FOXO), is required for all phenotypes associated with reduced insulin/insulin-like growth factor (Igf) signaling.", "negatives": ["The gene daf-16, which encodes forkhead Box O (FOXO), is required for all phenotypes associated with reduced insulin/insulin-like growth factor (Igf) signaling.", "miRNAs regulate a unique suite of mRNAs to maintain homeostasis in cells.", "Bone marrow cells don't contribute to adult macrophage compartments.", "Having a main partner improves HIV outcomes.", "The C-type lectin receptor (CLEC-2) rearranges the actin cytoskeleton in dendritic cells to promote efficient motility along stromal surfaces.", "Pyridostatin prevents double-strand breaks accumulation.", "PGE 2 suppresss intestinal tumor growth by altering the expression of tumor suppressing and DNA repair genes.", "Stroke patients with prior use of direct oral anticoagulants have a higher risk of in-hospital mortality than stroke patients with prior use of warfarin.", "Algerian physicians constitue the largest component of sub-Saharan Africa-trained physicians in the United States.", "There is no relation between Erythromycin use and hypertrophic pyloric stenosis."], "hard_negatives": ["Asymptomatic visual impairment screening in elderly populations leads to improved vision.", "Headaches are correlated with cognitive impairment.", "Physical activity does not improve cognitive function in individuals with Alzheimers.", "Individuals with Alzheimers who participate in six months of physical activity improve cognitive function for up to 18 months.", "Incidence of 10/66 dementia is lower than the incidence of DSM-IV dementia.", "Incidence of 10/66 dementia is higher than the incidence of DSM-IV dementia.", "In young and middle-aged adults, current or remote uses of ADHD medications increase the risk of serious cardiovascular events.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have decreased risk for dementia.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have increased risk for Alzheimer's disease.", "Nonhypertensive people who are 55 years old have a 90% chance of developing hypertension during their lifetime."], "hard_negative": "Asymptomatic visual impairment screening in elderly populations leads to improved vision."}
{"query_id": "139", "query_text": "At least 85% of patients exposed to radiation have activated markers of myofibroblasts.", "negative": "Chlamydia trachomatis is most prevalent in the UK among individuals in their 50s and 60s.", "negatives": ["Chlamydia trachomatis is most prevalent in the UK among individuals in their 50s and 60s.", "Mice are incapable of producing neutralizing antibodies in reponse to the Chikungunya virus (CHIKV) produced in mosquitos.", "Splenomegaly is observed in knockin mouse lacking the SHP-2 MAPK pathway.", "The risk of female prisoners harming themselves is ten times that of male prisoners.", "DRD1 proteins enable Pol V transcription in vivo.", "Intramembrane cleavage by signal peptide peptidase aids in the degradation of proteins with a complex membrane orientation.", "A deficiency of vitamin B12 decreases blood levels of homocysteine.", "70% of burn patients are admitted for hospitalization and further treatment after appearing at hospital emergency wards or outpatient clinics.", "Hematopoietic Stem Cell purification reaches purity rates above 90%.", "Excess gestational weight gain is associated with obesity-related pregnancy outcomes."], "hard_negatives": ["At least 85% of patients exposed to radiation have activated markers of myofibroblasts.", "Less than 10% of patients exposed to radiation have activated markers of mesenchymal stem cells.", "50% of patients exposed to radiation have activated markers of mesenchymal stem cells.", "Cancer-associated fibroblasts (CAFs) have no known interaction with cancer cells in the formation and activation of CAFs.", "1-1% of colorectal cancer patients are diagnosed with regional or distant metastases.", "61% of colorectal cancer patients are diagnosed with regional or distant metastases.", "Cancer-associated fibroblasts (CAFs) interact with cancer cells to mediate formation and activation of CAFs.", "Cancer-associated fibroblasts (CAFs) are constituents of tumor microenvironments", "Pro-inflammatory cytokines are up regulated during tumor development.", "Tumor development occurs in conjunction with upregulation of pro-inflammatory cytokines."], "hard_negative": "At least 85% of patients exposed to radiation have activated markers of myofibroblasts."}
{"query_id": "144", "query_text": "Autologous transplantation of mesenchymal stem cells has better graft function than induction therapy with anti-interleukin-2 receptor antibodies.", "negative": "JMJD6 slows the hydroxylation of C-terminal lysine", "negatives": ["JMJD6 slows the hydroxylation of C-terminal lysine", "Integrating classroom-based collaborative learning with Web-based collaborative learning offers the best class performance.", "One in two surgical randomized controlled trials are discontinued early.", "Cognitive behavioral therapy is an ineffective treatment for insomnia", "The NF-\u03baB essential modulator gene induces intestinal inflammation by promoting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death.", "Reducing H3k4me3 methylation induces mouse epiblast stem cells to naive pluripotency efficiently.", "Deregulation of HAND2 is a crucial step in endometrial carcinogenesis in mice.", "The minor G allele of FOXO3 is related to less severe symptoms of Crohn's Disease.", "The NF-\u03baB essential modulator gene prevents intestinal inflammation by inhibiting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death.", "Oxidative phosphorylation is one of the primary glycometabolic pathways in cells."], "hard_negatives": ["Autologous transplantation of mesenchymal stem cells has better graft function than induction therapy with anti-interleukin-2 receptor antibodies.", "Bone Marrow (BM) transplantation is used to treat acute myeloid leukemia (AML)", "Transplanted human glial progenitor cells can mature in their host animal.", "Induced hepatic stem cells possess the potential to differentiate into cholangiocytic cells.", "In breast cancer, the loss of myoepithelial cells slows the transition of ductal carcinoma in situ to invasive carcinoma.", "Homozygous deletion of murine Sbds gene from osterix-expressing mesenchymal stem and progenitor cells (MPCs) induces oxidative stress.", "In breast cancer, the loss of myoepithelial cells promotes the transition of ductal carcinoma in situ to invasive carcinoma.", "Repressing IL-18 has negative effects on atherosclerotic lesion composition and progression.", "Allogeneic mechanical circulatory support is not as effective as autologous mechanical circulatory support for treating acute myocardial infarction.", "Systemic immunosuppressive (IS) therapy increases the chance of cancer mortality in patients with inflammatory eye disease (IED)"], "hard_negative": "Autologous transplantation of mesenchymal stem cells has better graft function than induction therapy with anti-interleukin-2 receptor antibodies."}
{"query_id": "149", "query_text": "Autophagy deficiency in the liver increases vulnerability to insulin resistance.", "negative": "Differentiation of progenitor cells to myeloid cells is skewed when insulin signaling is suppressed.", "negatives": ["Differentiation of progenitor cells to myeloid cells is skewed when insulin signaling is suppressed.", "Chronic HIV stimulation of B cells leads to the premature exhaustion of B cells.", "At least 85% of patients exposed to radiation have activated markers of myofibroblasts.", "Pyridostatin deregulates G2/M progression.", "Increased mobility of retrotransposons is assosciated with mutation and higher tumorigenesis rates.", "A 100g dose of chloroquine chemoprophylactic regimen results in retinal toxicity after 1 year of weekly intake.", "Bariatric surgery reduces postmenopausal breast cancer.", "Human embryonic stem cells give rise to cell types from all three embryonic germ layers.", "Deleting Raptor increases G-CSF levels.", "Surgical treatment is not superior to non-surgical in treating adults with displaced fractures of the proximal humerus."], "hard_negatives": ["Autophagy deficiency in the liver increases vulnerability to insulin resistance.", "Insulin decreases risk of severe kidney failure.", "Insulin effects appetite via ventral tegmental neurons.", "Medications to treat obesity have unwanted side effects.", "Medications to treat obesity do not have side effects.", "A deficiency of folate increases blood levels of homocysteine.", "Mice lacking Sirt1 in Sf1-expressing neurons have increased susceptibility to diet-induced obesity and insulin resistance.", "Angiotensin converting enzyme inhibitors are associated with decreased risk for functional renal insufficiency.", "Ethanol stress increases the expression of IBP in bacteria.", "A mutation in HNF4A leads to an increased risk of developing diabetes by the age of 14 years."], "hard_negative": "Autophagy deficiency in the liver increases vulnerability to insulin resistance."}
{"query_id": "152", "query_text": "B cells go though plasmablast differentiation and antibody production by continuous expression of EBI2.", "negative": "RTEL1 interacts with TRF2 through a C4C4 motif", "negatives": ["RTEL1 interacts with TRF2 through a C4C4 motif", "Hypothalamic glutamate neurotransmission is unrelated to energy balance.", "H4 G94P proteins inhibit chromatin assembly, which decreases free histones.", "Cis-acting lncRNAs control the expression of genes that are positioned in the vicinity of their transcription sites.", "The proportion of people with visual difficulty is two times higher in low-income countries than in high-income countries.", "MICAL redox enzymes regulate actin dynamics.", "Forkhead 0 (fox0) transcription factors are involved in cellular differentiation.", "Bone marrow cells don't contribute to adult macrophage compartments.", "The recruitment of Wdr5 to its target loci depends on Kat8.", "Trans-acting factors, such as lncRNAs, influence mRNA translation."], "hard_negatives": ["B cells go though plasmablast differentiation and antibody production by continuous expression of EBI2.", "Varying expression levels of EBI2 affect the positioning and migration of B cells.", "Egr2 regulates the homeostasis of B and T cells.", "Egr3 regulates the homeostasis of B and T cells.", "Neutrophils produce IL-1\u03b2 in response to large particles.", "During the primary early antibody response activated B cells migrate toward the inner-and outer follicular areas where oxysterol accumulation is generated by stromal cells.", "TMEM27 is a marker for beta cells.", "The composition of myosin-II isoform switches from the A isoform to the B isoform during hematopoietic differentiation.", "Transcription factor EB induces transcription of pro-inflammatory cytokines in macrophages infected with Staphylococcus aureus.", "Exhaustion of B cells contributes to poor Ab response in HIV-infected individuals."], "hard_negative": "B cells go though plasmablast differentiation and antibody production by continuous expression of EBI2."}
{"query_id": "153", "query_text": "B3-Galectin decreases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR.", "negative": "Vitamin D deficiency effects birth weight.", "negatives": ["Vitamin D deficiency effects birth weight.", "The minor G allele of FOXO3 up-regulates IL-10.", "Cost effectiveness evaluations based on cRCT data lack external validity.", "Increased microtubule acetylation exacerbates LRRK2 Roc-COR domain mutation induced locomotor deficits.", "NAC inhibits the generation of angiotensin-converting enzyme.", "CCL19 is predominantly present within dLNs.", "Treatment with a protein named FN impairs regenerative abilities of aged muscles.", "There is a positive correlation between hip fractures and statin use.", "Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission.", "Primary cervical cytology screening with HPV detection has higher longitudinal sensitivity to detect severe cervical intraepithelial neoplasia than conventional cytology."], "hard_negatives": ["B3-Galectin decreases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR.", "B3-Galectin increases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR.", "ITAM phosphorylation allows for the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).", "Blocking the interaction between TDP-43 and respiratory complex I proteins ND3 and ND6 prevents TDP-43-induced neuronal loss.", "MUC1-C activates the NF-\u03baB p65 signaling pathway by interacting with I\u03baB kinase \u00df.", "Egr3 regulates the homeostasis of B and T cells.", "Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes fibrosis.", "C2 works synergistically with A-769662 to activate dephosphorylated AMPK.", "Kir7.1 modulates channel activity by the G protein-coupled melanocortin-4 receptor (MC4R) in the paraventricular nucleus of the hypothalamus.", "Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes epithelial damage."], "hard_negative": "B3-Galectin decreases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR."}
{"query_id": "154", "query_text": "B3-Galectin increases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR.", "negative": "Input from  mental and physical health care professionals is not effective at decreasing homelessness.", "negatives": ["Input from  mental and physical health care professionals is not effective at decreasing homelessness.", "Aged patients are less susceptible to ischaemia/reperfusion injury.", "Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes fibrosis.", "The US health care system can save up to $5 billion if 7% of patients waiting for kidney transplants participate in the optimized national kidney paired donation program.", "Anthrax spores remain deadly until affected areas are decontaminated.", "Cell autonomous sex determination in somatic cells occurs in Galliformes.", "Low expression of miR7a does not repress target genes or exert a biological function in ovaries.", "Distant CREs are important for transcriptional regulation.", "Mice defective for deoxyribonucleic acid (DNA) polymerase m (polm) fail to reveal increased sensitivity to ionizing radiation (IR).", "In a naive state, blocking Wingless-Int-1 secretion from mouse embryonic stem cells inhibits self-renewal of the mouse embryonic stem cells."], "hard_negatives": ["B3-Galectin decreases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR.", "B3-Galectin increases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR.", "ITAM phosphorylation allows for the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).", "Blocking the interaction between TDP-43 and respiratory complex I proteins ND3 and ND6 prevents TDP-43-induced neuronal loss.", "MUC1-C activates the NF-\u03baB p65 signaling pathway by interacting with I\u03baB kinase \u00df.", "Egr3 regulates the homeostasis of B and T cells.", "C2 works synergistically with A-769662 to activate dephosphorylated AMPK.", "Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes fibrosis.", "Kir7.1 modulates channel activity by the G protein-coupled melanocortin-4 receptor (MC4R) in the paraventricular nucleus of the hypothalamus.", "MEK inhibitors are effective treatments in RAS-driven mouse models of cancer."], "hard_negative": "B3-Galectin decreases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR."}
{"query_id": "155", "query_text": "BCL-2 activation antagonizes the apoptotic effects of c-Myc.", "negative": "Replacement of histone H2A with H2A.Z accelerates gene activation in yeasts by destabilizing +1 nucleosomes.", "negatives": ["Replacement of histone H2A with H2A.Z accelerates gene activation in yeasts by destabilizing +1 nucleosomes.", "Nonhuman primates are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.", "The recruitment of Wdr5 to its target loci depends on Kat8.", "Including pharmacists in rounding teams does not alter the incidence of adverse drug events (ADEs).", "Exposure to fine particulate air pollution is unrelated to anxiety prevalence.", "BCL-2 promotes the apoptotic effects of c-Myc.", "Aggravated inflammation is dependent on NLRP3 inflammasome activation.", "Radioiodine treatment of non-toxic multinodular goitre increases thyroid volume.", "CD44v6 is not associated with constitutive and reprogrammed cancer stem cells driving cancer metastasis.", "1-1% of colorectal cancer patients are diagnosed with regional or distant metastases."], "hard_negatives": ["BCL-2 activation antagonizes the apoptotic effects of c-Myc.", "BCL-2 promotes the apoptotic effects of c-Myc.", "Reduced phosphorylation of PP2A increases HDAC4 dephosphorylation by enhancing PP2A-HDAC4 interaction.", "Reduced phosphorylation of PP2A suppresses HDAC4 dephosphorylation.", "Cytochrome c is transferred from cytosol to the mitochondrial intermembrane space during apoptosis.", "The PDPN gene deactivates the C-type lectin receptor (CLEC-2).", "Gpr124 suppresses BBB breakdown in mouse models of ischemic stroke.", "Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes fibrosis.", "Activation of PPM1D enhances p53 function.", "Gpr124 increases BBB breakdown in mouse models of ischemic stroke."], "hard_negative": "BCL-2 activation antagonizes the apoptotic effects of c-Myc."}
{"query_id": "156", "query_text": "BCL-2 promotes the apoptotic effects of c-Myc.", "negative": "CDK6 shows improved binding to loss-of-function variants of p18 INK4C.", "negatives": ["CDK6 shows improved binding to loss-of-function variants of p18 INK4C.", "Physical activity does not improve cognitive function in individuals with Alzheimers.", "Rhythmic expression of Cry1 translates directly into a circadian regulation of cAMP signaling in gluconeogenesis.", "Pioglitazone use is significantly associated with an increased risk of pancreatic cancer.", "Urbanization is an important risk factor related to the transmission of dengue fever.", "Fibroblast growth factor 21 protects against atherosclerosis by modulating adiponectin and SREBP2 levels.", "32% of liver transplantation programs required patients to discontinue methadone treatment in 2001.", "Expression of oncolytic virus antigens as peptides permits additional protection against relapse.", "The deregulated and prolonged activation of monocytes improves inflammatory disease outcomes.", "Distant CREs are less conserved among species."], "hard_negatives": ["BCL-2 promotes the apoptotic effects of c-Myc.", "BCL-2 activation antagonizes the apoptotic effects of c-Myc.", "Reduced phosphorylation of PP2A increases HDAC4 dephosphorylation by enhancing PP2A-HDAC4 interaction.", "Reduced phosphorylation of PP2A suppresses HDAC4 dephosphorylation.", "Cytochrome c is transferred from cytosol to the mitochondrial intermembrane space during apoptosis.", "The PDPN gene deactivates the C-type lectin receptor (CLEC-2).", "G-CSF increases the expansion and infiltration of MDSCs into tumors.", "Gpr124 suppresses BBB breakdown in mouse models of ischemic stroke.", "5'-nucleotidase metabolizes 6MP.", "Gpr124 increases BBB breakdown in mouse models of ischemic stroke."], "hard_negative": "BCL-2 promotes the apoptotic effects of c-Myc."}
{"query_id": "157", "query_text": "BLM gene encodes RecQ-class DNA helicase.", "negative": "There is no known interaction between Pioneer factor OCT3/4 and major chromatin remodeling factors.", "negatives": ["There is no known interaction between Pioneer factor OCT3/4 and major chromatin remodeling factors.", "Converting apoE4 to apoE3 by gene editing worsens the pathology associated with apoE4 in human iPSCderived neurons.", "Increased vessel density along with a reduction in fibrosis improves the efficacy of chemotherapy treatments.", "Tumor development occurs in conjunction with upregulation of pro-inflammatory cytokines.", "Improvements in OER catalysts show stable activity over several hundred hours.", "One in two surgical randomized controlled trials are discontinued early.", "Misunderstandings between doctors and patients can lead to non-adherence.", "Insulin effects appetite via ventral tegmental neurons.", "The G34R/V mutation creates a hypomethylated phenotype at the H3K36 histone.", "Dexamethasone increases risk of postoperative bleeding."], "hard_negatives": ["BLM gene encodes RecQ-class DNA helicase.", "The PPR MDA5 has twenty N-terminal CARD domains.", "RAD52 is involved in break-induced DNA replication (BIR).", "The PRR MDA5 has a C-terminal domain.", "ScPif1p has higher binding ability to G-rich ssDNA than to non-G-rich ssDNA.", "Bcp1 is a chaperone for Rpl23.", "ScPif1p has reduced binding ability to G-rich ssDNA compared to non-G-rich ssDNA.", "R2D2 stops miRNA production by increasing the selectivity of Dcr2 for long dsRNA.", "The predominant localization of Linc00173 is in mononuclear macrophage nuclei.", "CCL19 is a ligand for CCR7."], "hard_negative": "BLM gene encodes RecQ-class DNA helicase."}
{"query_id": "159", "query_text": "BRCA 1 mutation carriers' risk of breast and ovarian cancer depends on where the mutation is located.", "negative": "Cancer cells can stimulate the accumulation of intra-tumoural myeloid-derived suppressor cells by promoting granulocyte colony stimulating factor production.", "negatives": ["Cancer cells can stimulate the accumulation of intra-tumoural myeloid-derived suppressor cells by promoting granulocyte colony stimulating factor production.", "The mean suicide rate in women is lower after miscarriage than live birth.", "90% of patients with melanoma and an objective response to PD-1 blockade will experience a progression in their melanoma.", "Destination container port throughput(CPT) is negatively related to dengue virus (DENV-1) diffusion in air traffic shipments.", "Monoclonal antibody targeting of N-cadherin encourages castration resistance.", "Treatment with a protein named FN restores regenerative abilities of aged muscles.", "Dexamethasone increases risk of postoperative bleeding.", "LRBA promotes CTLA - 4 recycling.", "Egr2 regulates the homeostasis of B and T cells.", "Ten percent (10%) of kidney cancers in the UK are attributable to excess weight."], "hard_negatives": ["BRCA 1 mutation carriers' risk of breast and ovarian cancer depends on where the mutation is located.", "The risk of breast cancer among parous women decreases with placental weight of pregnancies.", "ALDH1 expression is associated with poorer prognosis for breast cancer primary tumors.", "Carriers of HNF4A mutations are at reduced risk for diabetes.", "Birth-weight is negatively associated with breast cancer.", "Women with a lower birth weight are more likely to develop breast cancer later in life.", "Environmental factors can influence the development of breast cancer.", "Ten percent (10%) of kidney cancers in the UK are attributable to excess weight.", "HNF4A mutations are associated with macrosomia in infancy.", "In breast cancer, the loss of myoepithelial cells slows the transition of ductal carcinoma in situ to invasive carcinoma."], "hard_negative": "BRCA 1 mutation carriers' risk of breast and ovarian cancer depends on where the mutation is located."}
{"query_id": "160", "query_text": "Bacterial meningitis can be diagnosed on the basis of positive cerebrospinal fluid (CSF) cultures.", "negative": "The morphology change from large white adipocytes to small brown adipocytes is a sign of decreased energy expenditure potential in white adipose tissue.", "negatives": ["The morphology change from large white adipocytes to small brown adipocytes is a sign of decreased energy expenditure potential in white adipose tissue.", "Mice defective for deoxyribonucleic acid (DNA) polymerase m (polm) reveal increased sensitivity to ionizing radiation (IR).", "TRAP+ osteoclasts regulate mature osteoblast maintenance.", "Physical activity does not improve cognitive function in individuals with Alzheimers.", "Tonic signaling from the scFv induces constitutive stimulation.", "Microglia are an innate immune cell type of the central nervous system.", "PKG-la does not have a large impact on expression of pain hypersensitivity in PGK-la knockout mice.", "Eilat virus (EILV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in nonhuman primates.", "Allogeneic mechanical circulatory support is not as effective as autologous mechanical circulatory support for treating acute myocardial infarction.", "Removal of H3K9me3 by ectopic expression of other H3K9 demethylases improves reprogramming efficiency in SCNT experiments."], "hard_negatives": ["Bacterial meningitis can be diagnosed on the basis of positive cerebrospinal fluid (CSF) cultures.", "Women are more susceptible to death due to pneumonia when compared to men.", "Men are more susceptible to death due to pneumonia when compared to women.", "Chlamydia trachomatis is most prevalent in the UK among sexually-experienced individuals aged 16 to 24.", "A low percentage of hematopoietic progenitor cells are susceptible to HIV-1 infection ex vivo.", "Tuberculosis-induced granulomas express different immune system protein signatures than the surrounding tissue.", "Oat tolerant coeliac patients may have oat specific inflammatory cells in their small bowel mucosa.", "Roughly 55% of women with chronic pelvic pain have no underlying pathology.", "Chlamydia trachomatis is most prevalent in the UK among individuals in their 50s and 60s.", "Urbanization is an important risk factor related to the transmission of dengue fever."], "hard_negative": "Bacterial meningitis can be diagnosed on the basis of positive cerebrospinal fluid (CSF) cultures."}
{"query_id": "161", "query_text": "Bacteriophagaes MS2 and Q\u03b2 are members of the Leviviridae.", "negative": "HbA1c consistently overestimates glycemic control in black individuals with Sickle cell trait (SCT).", "negatives": ["HbA1c consistently overestimates glycemic control in black individuals with Sickle cell trait (SCT).", "B3-Galectin decreases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR.", "Cost effectiveness evaluations based on cRCT data lack external validity.", "Including pharmacists in rounding teams does not alter the incidence of adverse drug events (ADEs).", "LRBA prevents CTLA - 4 recycling.", "Inhibiting focal adhesion formation increases the rate at which cells convert mechanical strain into inflammation and fibrosis.", "In a naive state, blocking Wingless-Int-1 secretion from mouse embryonic stem cells inhibits self-renewal of the mouse embryonic stem cells.", "Human embryonic stem cells have the capacity to give rise to differentiated progeny representative of all three embryonic germ layers.", "Over half of the gabonese children with Schimmelpenning-Feuerstein-Mims syndrome (SFM) had a plasma lactate of more than 5mmol/L.", "The tissue surrounding the granuloma in an immune cell induces an anti-inflammatory immune response."], "hard_negatives": ["Bacteriophagaes MS2 and Q\u03b2 are members of the Leviviridae.", "Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 inhibit West Nile virus replication in cortical neurons.", "The PPR MDA5 has twenty N-terminal CARD domains.", "Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 encourage West Nile virus replication in cortical neurons.", "Commelina yellow mottle virus (ComYMV) has three typical badnavirus ORFs, capable of encoding proteins 23, 15, and 216 kD.", "Cancer-associated fibroblasts (CAFs) are constituents of tumor microenvironments", "Helminths interfere with immune system control of coinfections by microbial pathogens 16.", "Microglia are an innate immune cell type of the peripheral nervous system.", "Microglia are an innate immune cell type of the central nervous system.", "Basophils promote disease development in patients with systemic lupus erythematosus (SLE)."], "hard_negative": "Bacteriophagaes MS2 and Q\u03b2 are members of the Leviviridae."}
{"query_id": "164", "query_text": "Bariatric surgery increases rates of colorectal cancer.", "negative": "Reduced phosphorylation of PP2A increases HDAC4 dephosphorylation by enhancing PP2A-HDAC4 interaction.", "negatives": ["Reduced phosphorylation of PP2A increases HDAC4 dephosphorylation by enhancing PP2A-HDAC4 interaction.", "Broadly HIV-1 Neutralizing Antibodies (bnAb) 10EB have no affinity for phospholipids.", "Increased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm.", "Integrating classroom-based collaborative learning with Web-based collaborative learning offers the best class performance.", "Immune responses in immune cells are geographically segregated.", "Overexpressing Cnp1 N-tail variants exacerbates the temperature-sensitive growth defect of scm3-139.", "Formation of N-terminal pyroglutamate by glutamine cyclase (GC) competes with NTAQ1 for Nt-Gln substrates.", "miRNAs regulate a unique suite of mRNAs to maintain homeostasis in cells.", "Eliminating the last sporadic cases of malaria requires considerable funding.", "Increased lipolysis leads to higher P38 phosphorylation in adipose tissue."], "hard_negatives": ["Bariatric surgery reduces colorectal cancer.", "Bariatric surgery increases rates of colorectal cancer.", "Bariatric surgery increases rates of postmenopausal breast cancer.", "Bariatric surgery reduces postmenopausal breast cancer.", "Bariatric surgery leads to negative outcomes in mental health.", "Bariatric surgery leads to positive outcomes in mental health.", "61% of colorectal cancer patients are diagnosed with regional or distant metastases.", "1-1% of colorectal cancer patients are diagnosed with regional or distant metastases.", "Ten percent (10%) of kidney cancers in the UK are attributable to excess weight.", "CRP is positively correlated with postoperative mortality following Coronary Artery Bypass Graft (CABG) surgery."], "hard_negative": "Bariatric surgery reduces colorectal cancer."}
{"query_id": "165", "query_text": "Bariatric surgery increases rates of postmenopausal breast cancer.", "negative": "The deregulated and prolonged activation of monocytes improves inflammatory disease outcomes.", "negatives": ["The deregulated and prolonged activation of monocytes improves inflammatory disease outcomes.", "Repressing IL-18 has negative effects on atherosclerotic lesion composition and progression.", "Ca2+ cycling is a UCP1-dependent thermogenic mechanism.", "H4 G94P proteins induce chromatin assembly, which increases free histones.", "In transgenic mice harboring green florescent protein under the control of the Sox2 promoter, more than 50 percent of the cells with green florescent colocalize with cell proliferation markers.", "N348I mutations cause resistance to nevirapine.", "One in two surgical randomized controlled trials are discontinued early.", "Long - range chromatin interactions regulate transcription.", "Metastatic colorectal cancer treated with a single agent fluoropyrimidines resulted in similar efficacy and better quality of life when compared with oxaliplatin-based chemotherapy in elderly patients.", "DMS3 protein enables Pol V transcription in vivo."], "hard_negatives": ["Bariatric surgery increases rates of postmenopausal breast cancer.", "Bariatric surgery reduces postmenopausal breast cancer.", "Bariatric surgery reduces colorectal cancer.", "Bariatric surgery increases rates of colorectal cancer.", "Women with a lower birth weight are more likely to develop breast cancer later in life.", "The risk of breast cancer among parous women decreases with placental weight of pregnancies.", "Bariatric surgery leads to negative outcomes in mental health.", "Bariatric surgery leads to positive outcomes in mental health.", "Birth-weight is negatively associated with breast cancer.", "In breast cancer, the loss of myoepithelial cells promotes the transition of ductal carcinoma in situ to invasive carcinoma."], "hard_negative": "Bariatric surgery increases rates of postmenopausal breast cancer."}
{"query_id": "166", "query_text": "Bariatric surgery leads to negative outcomes in mental health.", "negative": "Anthrax spores are very difficult to dispose once they are dispersed.", "negatives": ["Anthrax spores are very difficult to dispose once they are dispersed.", "Mutant mice lacking SVCT2 have severely reduced ascorbic acid levels in both brain and adrenals.", "Ethanol stress increases the expression of PSP in bacteria.", "Up-regulation of the p53 pathway and related molecular events speeds cancer progression.", "Students who perform poorly in the early years of medical school are less likely to commit professional misconduct later in their careers.", "4-PBA treatment decreases endoplasmic reticulum stress in response to general endoplasmic reticulum stress markers.", "M. stadtmanae does not induce ASC speck formation in BlaER1 monocytes.", "In transgenic mice harboring green florescent protein under the control of the Sox2 promoter, more than 50 percent of the cells with green florescent colocalize with cell proliferation markers.", "Gpr124 increases BBB breakdown in mouse models of ischemic stroke.", "Epidemiological disease burden from noncommunicable diseases is more prevalent in high economic settings."], "hard_negatives": ["Bariatric surgery leads to negative outcomes in mental health.", "Bariatric surgery leads to positive outcomes in mental health.", "Bariatric surgery reduces colorectal cancer.", "Bariatric surgery increases rates of colorectal cancer.", "Bariatric surgery reduces postmenopausal breast cancer.", "Bariatric surgery increases rates of postmenopausal breast cancer.", "Surgical treatment is not superior to non-surgical in treating adults with displaced fractures of the proximal humerus.", "Rotator cuff exercises are more effective than general exercise therapy in reducing pain and improving function of the shoulder.", "General exercise therapy is more effective than rotator cuff exercises in reducing pain and improving function of the shoulder.", "Roughly 55% of women with chronic pelvic pain have no underlying pathology."], "hard_negative": "Bariatric surgery leads to negative outcomes in mental health."}
{"query_id": "167", "query_text": "Bariatric surgery leads to positive outcomes in mental health.", "negative": "Increased LDL receptors plays a role in the reduction of plasma Lp(a).", "negatives": ["Increased LDL receptors plays a role in the reduction of plasma Lp(a).", "The peak incidence of fractures occurs in toddlers.", "Nonsteroidal antinflammatory drugs are ineffective as cancer treatments.", "Mutations in G-Beta protein GNB1 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.", "Monoclonal antibody targeting of N-cadherin encourages castration resistance.", "p75 NTR - associated cell death executor (NADE) interacts with the p75 NTR death domain", "MafA phosphorylation decreases its ubiquitination.", "CRP is positively correlated with postoperative mortality following Coronary Artery Bypass Graft (CABG) surgery.", "Hematopoietic Stem Cell purification reaches purity rates above 90%.", "R2D2 stops miRNA production by increasing the selectivity of Dcr2 for long dsRNA."], "hard_negatives": ["Bariatric surgery leads to positive outcomes in mental health.", "Bariatric surgery leads to negative outcomes in mental health.", "Bariatric surgery reduces colorectal cancer.", "Bariatric surgery increases rates of colorectal cancer.", "Bariatric surgery reduces postmenopausal breast cancer.", "Bariatric surgery increases rates of postmenopausal breast cancer.", "Surgical treatment is not superior to non-surgical in treating adults with displaced fractures of the proximal humerus.", "Rotator cuff exercises are more effective than general exercise therapy in reducing pain and improving function of the shoulder.", "General exercise therapy is more effective than rotator cuff exercises in reducing pain and improving function of the shoulder.", "Scapular stabilizer exercises are more effective than general exercise therapy in reducing pain and improving function of the shoulder."], "hard_negative": "Bariatric surgery leads to positive outcomes in mental health."}
{"query_id": "168", "query_text": "Bariatric surgery reduces colorectal cancer.", "negative": "Walking in traffic areas in London improves lung function in elderly adults.", "negatives": ["Walking in traffic areas in London improves lung function in elderly adults.", "Comparative transcriptome analysis identified new platelet proteins with structural features suggesting a role in platelet function.", "Bone Marrow (BM) transplantation is used to treat acute myeloid leukemia (AML)", "Taking anti-depresents is associated with a decrease in the A\u03b2 level in the brain of experimental animals.", "Mice defective for deoxyribonucleic acid (DNA) polymerase m (polm) fail to reveal increased sensitivity to ionizing radiation (IR).", "ALDH1 expression is associated with poorer prognosis for breast cancer primary tumors.", "Increased mobility of retrotransposons is assosciated with mutation and higher tumorigenesis rates.", "Genes involved in pre-mRNA splicing have a significant impact on genome stability.", "EG7 tumors can be killed by systemic oxaliplatin primed CD8+ T cells from the tumor-draining lymph node cells.", "PrimPol degrades short DNA replication intermediates on the leading strand during DNA replication."], "hard_negatives": ["Bariatric surgery reduces colorectal cancer.", "Bariatric surgery increases rates of colorectal cancer.", "Bariatric surgery reduces postmenopausal breast cancer.", "Bariatric surgery increases rates of postmenopausal breast cancer.", "Bariatric surgery leads to negative outcomes in mental health.", "Bariatric surgery leads to positive outcomes in mental health.", "61% of colorectal cancer patients are diagnosed with regional or distant metastases.", "1-1% of colorectal cancer patients are diagnosed with regional or distant metastases.", "Ten percent (10%) of kidney cancers in the UK are attributable to excess weight.", "Metastatic colorectal cancer treated with a single agent fluoropyrimidines resulted in similar efficacy and better quality of life when compared with oxaliplatin-based chemotherapy in elderly patients."], "hard_negative": "Bariatric surgery reduces colorectal cancer."}
{"query_id": "169", "query_text": "Bariatric surgery reduces postmenopausal breast cancer.", "negative": "Increased flux of microbial products suppresses immune responses.", "negatives": ["Increased flux of microbial products suppresses immune responses.", "Tirasemtiv targets fast-twitch muscle.", "Excess gestational weight gain is associated with obesity-related pregnancy outcomes.", "Major antigen-induced signals from the T cell receptor and secondary signals from costimulatory receptors are required for T cell activation.", "Clathrin stabilizes the spindle fiber apparatus during mitosis.", "Upregulation of PD1 causes the downmodulation of Satb1.", "Genes regulated by Esrrb transcription factor are sensitive to Mbd3 function.", "Lamins are found within the inner layer of the mitochondrial membrane of all cells.", "Gpr124 suppresses BBB breakdown in mouse models of ischemic stroke.", "In British Men, haplogroup I increases risk of cardiovascular disease by 50%."], "hard_negatives": ["Bariatric surgery reduces postmenopausal breast cancer.", "Bariatric surgery increases rates of postmenopausal breast cancer.", "Bariatric surgery reduces colorectal cancer.", "Bariatric surgery increases rates of colorectal cancer.", "Women with a lower birth weight are more likely to develop breast cancer later in life.", "The risk of breast cancer among parous women decreases with placental weight of pregnancies.", "Bariatric surgery leads to negative outcomes in mental health.", "Bariatric surgery leads to positive outcomes in mental health.", "In breast cancer, the loss of myoepithelial cells promotes the transition of ductal carcinoma in situ to invasive carcinoma.", "Ten percent (10%) of kidney cancers in the UK are attributable to excess weight."], "hard_negative": "Bariatric surgery reduces postmenopausal breast cancer."}
{"query_id": "172", "query_text": "Basophils promote disease development in patients with systemic lupus erythematosus (SLE).", "negative": "HIV trans-activator protein (TAT) effectively transports large and small molecules across cellular membranes into larger populations of neurons.", "negatives": ["HIV trans-activator protein (TAT) effectively transports large and small molecules across cellular membranes into larger populations of neurons.", "Algerian physicians constitue the largest component of sub-Saharan Africa-trained physicians in the United States.", "Phase information is useful for predicting donor-recipient matches in organ transplantation.", "Urbanization is an important risk factor related to the transmission of dengue fever.", "TNFAIP3 is a glioblastoma tumor enhancer.", "Bariatric surgery reduces colorectal cancer.", "H4 G94P proteins induce chromatin assembly, which increases free histones.", "The latent infection of myeloid cells with human cytomegalovirus induces a number of changes in gene expression.", "Cytosolic proteins bind to iron-responsive elements on mRNAs coding for TFRC1.", "Aggravated inflammation is dependent on NLRP3 inflammasome activation."], "hard_negatives": ["Basophils promote disease development in patients with systemic lupus erythematosus (SLE).", "Neutrophils produce IL-1\u03b2 in response to large particles.", "A T helper 2 cell (Th2) environment impedes disease development in patients with systemic lupus erythematosus (SLE).", "Lipopolysaccharides have an inflammation independent effect on kidney barrier function.", "Bacteriophagaes MS2 and Q\u03b2 are members of the Leviviridae.", "G-CSF increases the expansion and infiltration of MDSCs into tumors.", "Systemic lupus erythematosus is a risk factor for cardiovascular disease.", "The tissue surrounding the granuloma in an immune cell induces an anti-inflammatory immune response.", "Many transmembrane receptors transmit signals by long-range conformational changes in the association of alpha-helices across the plasma membrane.", "B cells go though plasmablast differentiation and antibody production by continuous expression of EBI2."], "hard_negative": "Basophils promote disease development in patients with systemic lupus erythematosus (SLE)."}
{"query_id": "173", "query_text": "Bcp1 is a chaperone for Rpl23.", "negative": "Removal of H3K9me3 improves reprogramming efficiency in human somatic cell nuclear transfer experiments.", "negatives": ["Removal of H3K9me3 improves reprogramming efficiency in human somatic cell nuclear transfer experiments.", "Obesity raises life quality.", "The NF-\u03baB essential modulator gene prevents intestinal inflammation by inhibiting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death.", "The DESMOND program demonstrates no significant impact on biochemical outcomes.", "Pre-mRNAs associated with spliceosomal components are more stable than unassociated splicing substrates.", "Long chain polyunsaturated fatty acids supplementation reduces wheezing and asthma.", "LRBA prevents CTLA - 4 recycling.", "The proportion of people with visual difficulty is two times higher in low-income countries than in high-income countries.", "Pure neural progenitor cell (NPC) populations can only be obtained from cell cultures that undergo passaging, filtration, or other isolation and cell sorting methods.", "Oxidative DNA damage activates STING signalling."], "hard_negatives": ["Bcp1 is a chaperone for Rpl23.", "The PPR MDA5 has twenty N-terminal CARD domains.", "mcm 5 s 2 U is required for proper decoding of NNR codons in eukaryotes.", "ScPif1p has higher binding ability to G-rich ssDNA than to non-G-rich ssDNA.", "CCL19 is predominantly present within dLNs.", "ScPif1p has reduced binding ability to G-rich ssDNA compared to non-G-rich ssDNA.", "Active caspase-11 participate in regulating phagosome-lysosome fusion.", "CCL19 is a ligand for CCR7.", "BLM gene encodes RecQ-class DNA helicase.", "Lack of FGF21 in mice increases life expectancy."], "hard_negative": "Bcp1 is a chaperone for Rpl23."}
{"query_id": "174", "query_text": "Beta-band coherence is diminished for visible stimuli over invisible stimuli.", "negative": "Cancer-associated fibroblasts (CAFs) are constituents of tumor microenvironments", "negatives": ["Cancer-associated fibroblasts (CAFs) are constituents of tumor microenvironments", "Therapeutics receiving accelerated approval encounter a lower frequency of post-marketing safety events", "r-protein chaperones are found in complexes with their r-protein binding partners.", "Physical activity does not improve cognitive function in individuals with Alzheimers.", "HOXB4 is a highly expressed component of cellular secretome from fetal liver cell populations.", "PKG-la does not have a large impact on expression of spinal long term potentiation in PGK-la knockout mice.", "Induction of urokinase receptor signaling in podocytes causes foot process effacement and proteinuria.", "MafA phosphorylation enhances its ubiquitination.", "76-85% of people with severe mental disorder receive no treatment in low and middle income countries.", "The proliferative capacity of neural progenitors differs across species."], "hard_negatives": ["Beta-band coherence is diminished for visible stimuli over invisible stimuli.", "Beta-band coherence is enhanced for visible stimuli over invisible stimuli.", "Many transmembrane receptors transmit signals by long-range conformational changes in the association of alpha-helices across the plasma membrane.", "The density of cytokine receptor bearing cells has no effect on the distance over which cytokines act.", "Glial calcium waves influence seizures.", "Occipital activation levels are associated with auditory spatial performance in parietal regions of the brain.", "The density of cytokine receptor bearing cells affects the distance over which cytokines act.", "Taking anti-depresents is associated with a decrease in the A\u03b2 level in the brain of experimental animals.", "Varying expression levels of EBI2 affect the positioning and migration of B cells.", "Lack of FGF21 in mice leads to atherosclerotic plaque formation."], "hard_negative": "Beta-band coherence is diminished for visible stimuli over invisible stimuli."}
{"query_id": "175", "query_text": "Beta-band coherence is enhanced for visible stimuli over invisible stimuli.", "negative": "Cellular clocks are associated with mitosis timing in NIH 3T3 cells.", "negatives": ["Cellular clocks are associated with mitosis timing in NIH 3T3 cells.", "Reduction of purity of cytoplasmic membranes isolated from overexpressors is indicated by stronger spots for OmpA in 2D BN-PAGE gels.", "Two variants of chromosome 6q21 are associated with radiation therapy-induced second malignancies in pediatric Hodgkin lymphoma patients.", "A 100g dose of chloroquine chemoprophylactic regimen results in retinal toxicity after 1 year of weekly intake.", "The C-type lectin receptor (CLEC-2) rearranges the actin cytoskeleton in dendritic cells to promote efficient motility along stromal surfaces.", "Rapamycin increases the concentration of triacylglycerols in fruit flies.", "Sepsis related mortality has risen from 2009 to 2014.", "siRNA knockdown of A20 accelerates tumor progression in an in vivo murine xenograft model.", "APOE4 expression in iPSC-derived neurons results in decreased tau phosphorylation.", "RTEL1 interacts with TRF2 through a C4C4 motif"], "hard_negatives": ["Beta-band coherence is enhanced for visible stimuli over invisible stimuli.", "Beta-band coherence is diminished for visible stimuli over invisible stimuli.", "Many transmembrane receptors transmit signals by long-range conformational changes in the association of alpha-helices across the plasma membrane.", "Occipital activation levels are associated with auditory spatial performance in parietal regions of the brain.", "Glial calcium waves influence seizures.", "The density of cytokine receptor bearing cells has no effect on the distance over which cytokines act.", "Neutrophils produce IL-1\u03b2 in response to large particles.", "Varying expression levels of EBI2 affect the positioning and migration of B cells.", "Myelin sheaths play a role in action potential propagation.", "The density of cytokine receptor bearing cells affects the distance over which cytokines act."], "hard_negative": "Beta-band coherence is enhanced for visible stimuli over invisible stimuli."}
{"query_id": "176", "query_text": "BiP is a general endoplasmic reticulum stress marker.", "negative": "During the primary early antibody response activated B cells migrate toward the inner-and outer follicular areas where oxysterol accumulation is generated by stromal cells.", "negatives": ["During the primary early antibody response activated B cells migrate toward the inner-and outer follicular areas where oxysterol accumulation is generated by stromal cells.", "Pyridostatin reduces proliferation of homologous recombination - defective cells.", "Anthrax spores remain deadly until affected areas are decontaminated.", "Crossover hot spots are found within gene promoters in Saccharomyces cerevisiae.", "Tirasemtiv targets fast-twitch muscle.", "ScPif1p has reduced binding ability to G-rich ssDNA compared to non-G-rich ssDNA.", "Varenicline monotherapy is more effective after 26 weeks of treatment compared to combination nicotine replacement therapies with varenicline or bupropion.", "A deficiency of folate increases blood levels of homocysteine.", "H4 G94P proteins induce chromatin assembly, which increases free histones.", "Cost effectiveness evaluations based on cRCT data lack external validity."], "hard_negatives": ["BiP is a general endoplasmic reticulum stress marker.", "CHOP is a general endoplasmic reticulum stress marker.", "ATF4 is a general endoplasmic reticulum stress marker.", "4-PBA treatment decreases endoplasmic reticulum stress in response to general endoplasmic reticulum stress markers.", "4-PBA treatment raises endoplasmic reticulum stress in response to general endoplasmic reticulum stress markers.", "Ribosomal protein (RP) expression is controlled in part by stress-activated regulators.", "Many transmembrane receptors transmit signals by long-range conformational changes in the association of alpha-helices across the plasma membrane.", "Mice lacking Sirt1 in Sf1-expressing neurons are immune to diet-induced obesity and insulin resistance.", "Mice lacking Sirt1 in Sf1-expressing neurons have increased susceptibility to diet-induced obesity and insulin resistance.", "MFGE8 regulates fat absorption by binding to av-Beta3 and av-Beta5 integrins."], "hard_negative": "BiP is a general endoplasmic reticulum stress marker."}
{"query_id": "177", "query_text": "Binding of p53 to enhancer regions (p53BERs) regulates the activity of p53 transcription and cell cycle arrest through the production of p53-dependent eRNAs.", "negative": "Cancer-associated fibroblasts (CAFs) are constituents of tumor microenvironments", "negatives": ["Cancer-associated fibroblasts (CAFs) are constituents of tumor microenvironments", "Bariatric surgery reduces postmenopausal breast cancer.", "Cost effectiveness evaluations based on cRCT data lack external validity.", "FACT and other histone chaperone(s) compensate for Histone 2A (H2A)-histone 2B (H2B) dimer eviction during the histone exchange process.", "B3-Galectin increases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR.", "Broadly HIV-1 Neutralizing Antibodies (bnAb) 10EB have no affinity for phospholipids.", "Cognitive behavioral therapy is an ineffective treatment for insomnia", "Cancers that initially benefit from epidermal growth factor receptor targeted therapies later become refractory through several mechanisms.", "Adult tissue-resident macrophages are seeded before birth.", "Ectopic expression of Sall4, Nanog, Esrrb, and Lin28 generates induced pluripotent stem cells from mouse embryonic fibroblasts more efficiently than other factor combinations."], "hard_negatives": ["Binding of p53 to enhancer regions (p53BERs) regulates the activity of p53 transcription and cell cycle arrest through the production of p53-dependent eRNAs.", "Activation of PPM1D enhances p53 function.", "Up-regulation of the p53 pathway and related molecular events speeds cancer progression.", "Activated Cdk5 regulates DNA damage-induced neuronal death.", "Activated Cdk5 phosphorylates the ATM protein in response to DNA damage.", "Foxp3 enables the expression of transcriptional regulators implicated in memory T cell development.", "Foxp3 represses the expression of transcriptional regulators implicated in memory T cell development.", "eRNAs influence is linked to senescence, aging, and carcinogenesis.", "Active caspase-11 participate in regulating phagosome-lysosome fusion.", "Rhythmic expression of Cry1 translates directly into a circadian regulation of cAMP signaling in gluconeogenesis."], "hard_negative": "Binding of p53 to enhancer regions (p53BERs) regulates the activity of p53 transcription and cell cycle arrest through the production of p53-dependent eRNAs."}
{"query_id": "178", "query_text": "Birth-weight is negatively associated with breast cancer.", "negative": "Taking anti-depresents is associated with a decrease in the A\u03b2 level in the brain of experimental animals.", "negatives": ["Taking anti-depresents is associated with a decrease in the A\u03b2 level in the brain of experimental animals.", "Hypocretin neurones suppress panicprone state in rats.", "The predominant localization of Linc00173 is in mononuclear macrophage nuclei.", "Specialized functional cell types can be derived from human pluripotent stem cells.", "Glioblastoma multiforme (GBM) is characterized by extensive invasion, rapid growth, necrosis, and angiogenesis.", "Chemical injury represses transglutaminase 2 activity.", "H.pylori-mediated gastric cancer occurs due to the accumulation of mutations in host epithelial cells.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have decreased risk for dementia.", "Ethanol stress increases the expression of PSP in bacteria.", "Clathrin stabilizes the spindle fiber apparatus during mitosis."], "hard_negatives": ["Birth-weight is negatively associated with breast cancer.", "Women with a lower birth weight are more likely to develop breast cancer later in life.", "The risk of breast cancer among parous women decreases with placental weight of pregnancies.", "53% of perinatal mortality is due to low birth weight.", "Excess gestational weight gain is associated with obesity-related pregnancy outcomes.", "Vitamin D deficiency effects birth weight.", "The mean suicide rate in women is lower after miscarriage than live birth.", "The mean suicide rate in women is higher after miscarriage than live birth.", "Ten percent (10%) of kidney cancers in the UK are attributable to excess weight.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have shorter lifetime exposure to estrogen due to a decreased reproductive period."], "hard_negative": "Birth-weight is negatively associated with breast cancer."}
{"query_id": "181", "query_text": "Blocking the interaction between TDP-43 and respiratory complex I proteins ND3 and ND6 prevents TDP-43-induced neuronal loss.", "negative": "MeCP2 influences the synaptic maturation of neurons.", "negatives": ["MeCP2 influences the synaptic maturation of neurons.", "Mice defective for deoxyribonucleic acid (DNA) polymerase m (polm) fail to reveal increased sensitivity to ionizing radiation (IR).", "Patients with panic anxiety show decreased CSF levels of hypocretin.", "Citrullinated proteins externalized in neutrophil extracellular traps act indirectly to perpetuate the inflammatory cycle via induction of autoantibodies.", "Inhibiting focal adhesion formation increases the rate at which cells convert mechanical strain into inflammation and fibrosis.", "Omnivores produce less trimethylamine N-oxide from dietary I-carnitine than vegans.", "Fibroblast Growth Factor is a ligand which signals through receptor tyrosine kinases.", "ScPif1p has reduced binding ability to G-rich ssDNA compared to non-G-rich ssDNA.", "MafA phosphorylation enhances its ubiquitination.", "The NF-\u03baB essential modulator gene prevents intestinal inflammation by inhibiting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death."], "hard_negatives": ["Blocking the interaction between TDP-43 and respiratory complex I proteins ND3 and ND6 prevents TDP-43-induced neuronal loss.", "ITAM phosphorylation allows for the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).", "Foxp3 represses the expression of transcriptional regulators implicated in memory T cell development.", "Foxp3 enables the expression of transcriptional regulators implicated in memory T cell development.", "Reduced responsiveness to interleukin-2 in regulatory T cells is associated with autoimmune diseases such as Type 1 Diabetes.", "Gpr124 suppresses BBB breakdown in mouse models of ischemic stroke.", "IL-10 production by monocytes inhibits CD4 + T cell response.", "Certain immunomodulator-human dialyzable leukocyte extract (hDLE) peptides are recognized by toll-like receptors (TLRs) on macrophages and dendritic cells.", "Gpr124 increases BBB breakdown in mouse models of ischemic stroke.", "B3-Galectin decreases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR."], "hard_negative": "Blocking the interaction between TDP-43 and respiratory complex I proteins ND3 and ND6 prevents TDP-43-induced neuronal loss."}
{"query_id": "182", "query_text": "Bone Marrow (BM) transplantation is used to treat acute myeloid leukemia (AML)", "negative": "Walking in traffic areas in London improves lung function in elderly adults.", "negatives": ["Walking in traffic areas in London improves lung function in elderly adults.", "Individuals with Alzheimers who participate in six months of physical activity improve cognitive function for up to 18 months.", "Diabetic patients with acute coronary syndrome experience decreased short-term and long-term risk for bleeding events.", "Human embryonic stem cells give rise to cell types from the outer embryonic germ layer, but not the other two layers.", "Neutrophils produce IL-1\u03b2 in response to large particles.", "DMS3 protein enables Pol V transcription in vivo.", "Primary cervical cancer screening with HPV detection has lower longitudinal sensitivity than conventional cytology to detect cervical intraepithelial neoplasia grade 2.", "Cardiac tissue-resident macrophages directly contribute to electrical activity.", "A country's Vaccine Alliance (GAVI) eligibility is not indictivate of accelerated adoption of the Hub vaccine.", "PKG-la does not have a large impact on expression of pain hypersensitivity in PGK-la knockout mice."], "hard_negatives": ["Bone Marrow (BM) transplantation is used to treat acute myeloid leukemia (AML)", "Glioblastoma multiforme (GBM) is characterized by extensive invasion, rapid growth, necrosis, and angiogenesis.", "The latent infection of myeloid cells with human cytomegalovirus induces a number of changes in gene expression.", "Approximately 250,000 people are infected with human T-cell lymphotropic virus type 1 in the United Kingdom.", "Klf2 is important for proper myeloid cell function.", "Chronic HIV stimulation of B cells leads to the premature exhaustion of B cells.", "Bone marrow cells don't contribute to adult macrophage compartments.", "Klf4 is not required for proper myeloid cell differentiation.", "Cancer-associated fibroblasts (CAFs) are constituents of tumor microenvironments", "Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes fibrosis."], "hard_negative": "Bone Marrow (BM) transplantation is used to treat acute myeloid leukemia (AML)"}
{"query_id": "184", "query_text": "Bone marrow cells don't contribute to adult macrophage compartments.", "negative": "The DdrB protein from Deinococcus radiodurans functions as a pentamer.", "negatives": ["The DdrB protein from Deinococcus radiodurans functions as a pentamer.", "Binding of p53 to enhancer regions (p53BERs) regulates the activity of p53 transcription and cell cycle arrest through the production of p53-dependent eRNAs.", "Higher plasma levels of I-carnitine, when associated with trimethylamine N-oxide, are negatively correlated with cardiovascular events in humans.", "Tonic signaling from the scFv prevents constitutive stimulation.", "Antidepressants reduce the severity of migraines.", "Retinoic acid receptor-related orphan receptor gamma (ROR\u03b3) is a therapeutic target for castration-resistant prostate cancer (CRPC)", "Female carriers of the Apolipoprotein E4 (APOE4) allele have decreased risk for dementia.", "Addition of BMP4, activin A, CHIR99021, and SU504 to reprogramming fibroblasts generates, expands and maintains cardiovascular progenitor cells (CPCs)", "Eliminating the last sporadic cases of malaria requires considerable funding.", "Overexpressing Cnp1 N-tail variants exacerbates the temperature-sensitive growth defect of scm3-139."], "hard_negatives": ["Bone marrow cells don't contribute to adult macrophage compartments.", "Adult tissue-resident macrophages stem from the embryonal yolk sac and fetal liver.", "Adult tissue-resident macrophages stem from the embryonal yolk sac and fetal liver.", "Adult tissue-resident macrophages possess a self-renewing capacity.", "Adult tissue-resident macrophages are seeded before birth.", "Adult tissue-resident macrophages are seeded before birth.", "Cardiac tissue-resident macrophages directly contribute to electrical activity.", "Differentiation of progenitor cells to myeloid cells is skewed upon activation of insulin signaling.", "Human embryonic stem cells give rise to cell types from the outer embryonic germ layer, but not the other two layers.", "Differentiation of progenitor cells to myeloid cells is skewed when insulin signaling is suppressed."], "hard_negative": "Bone marrow cells don't contribute to adult macrophage compartments."}
{"query_id": "186", "query_text": "British female students are bullied more than British male students.", "negative": "Misunderstandings between doctors and patients can lead to non-adherence.", "negatives": ["Misunderstandings between doctors and patients can lead to non-adherence.", "Patients in stable partnerships have a slower progression from HIV to AIDS.", "The morphology change from large white adipocytes to small brown adipocytes is a sign of increased energy expenditure potential in white adipose tissue.", "The repeat-variable diresidue (RVD) in the loop of Transcription-Activator Like (TAL) effectors specifies the nucleotides-amino acid contact at the target promoter element.", "Distant CREs are important for transcriptional regulation.", "Decreased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm.", "In young and middle-aged adults, current or remote uses of ADHD medications increase the risk of serious cardiovascular events.", "Guanine nucleotide exchange factors (GEFs) mediate RhoA activation in response to tensional forces on fibronectin-binding integrins.", "Nonsteroidal antinflammatory drugs show potential anticancer indications.", "Rapamycin increases the concentration of triacylglycerols in fruit flies."], "hard_negatives": ["British female students are bullied more than British male students.", "British male students are bullied more than British female students.", "The risk of female prisoners harming themselves is ten times that of male prisoners.", "In the UK, drowning affects boys and girls equally.", "The mean suicide rate in women is higher after miscarriage than live birth.", "The mean suicide rate in women is lower after miscarriage than live birth.", "Women with a lower birth weight are more likely to develop breast cancer later in life.", "Chlamydia trachomatis is most prevalent in the UK among sexually-experienced individuals aged 16 to 24.", "Students who perform poorly in the early years of medical school are at increased risk for professional misconduct later in their careers.", "Students who perform poorly in the early years of medical school are less likely to commit professional misconduct later in their careers."], "hard_negative": "British female students are bullied more than British male students."}
{"query_id": "187", "query_text": "British male students are bullied more than British female students.", "negative": "Recognition of start codons depends on the translation initiation factor IF3.", "negatives": ["Recognition of start codons depends on the translation initiation factor IF3.", "Alirocumab treatment reduces apo(a) fractional clearance rate.", "Reduction of Rpl38 alters the composition of the Hox gene mRNAs translation in mice without lowering overall protein synthesis.", "Folate and vitamin B12 levels influence the association between homocysteine and preeclampsia.", "p75 NTR - associated cell death executor (NADE) interacts with the p75 NTR death domain", "Overexpressing Cnp1 N-tail variants exacerbates the temperature-sensitive growth defect of scm3-139.", "90% of patients with melanoma and an objective response to PD-1 blockade will experience a progression in their melanoma.", "Low nucleosome occupancy correlates with high methylation levels across species.", "Pre-mRNAs associated with spliceosomal components are less stable than unassociated splicing substrates.", "61% of colorectal cancer patients are diagnosed with regional or distant metastases."], "hard_negatives": ["British male students are bullied more than British female students.", "British female students are bullied more than British male students.", "The risk of female prisoners harming themselves is ten times that of male prisoners.", "In the UK, drowning affects boys and girls equally.", "Chlamydia trachomatis is most prevalent in the UK among sexually-experienced individuals aged 16 to 24.", "Women with a lower birth weight are more likely to develop breast cancer later in life.", "Students who perform poorly in the early years of medical school are at increased risk for professional misconduct later in their careers.", "The mean suicide rate in women is higher after miscarriage than live birth.", "The mean suicide rate in women is lower after miscarriage than live birth.", "Students who perform poorly in the early years of medical school are less likely to commit professional misconduct later in their careers."], "hard_negative": "British male students are bullied more than British female students."}
{"query_id": "189", "query_text": "Broadly HIV-1 Neutralizing Antibodies (bnAb) 10EB have no affinity for phospholipids.", "negative": "LSD1-positive promoters are associated with RNA polymerase II", "negatives": ["LSD1-positive promoters are associated with RNA polymerase II", "Women are more susceptible to death due to pneumonia when compared to men.", "Increased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm.", "De novo assembly of sequence data has fewer specific contigs than unassembled sequence data.", "Bariatric surgery increases rates of colorectal cancer.", "Low nucleosome occupancy correlates with high methylation levels across species.", "Ca2+ cycling is a UCP1-dependent thermogenic mechanism.", "Increased microtubule acetylation repairs interference of axonal transport caused by LRRK2 Roc-COR domain mutations.", "Upon viral challenge, influenza-specific memory CD4+ T cells greatly enhance the early production of inflammatory chemokines in the lung.", "Rising temperatures caused by global warming lowers the risk of dengue fever transmission."], "hard_negatives": ["Broadly HIV-1 Neutralizing Antibodies (bnAb) 10EB have no affinity for phospholipids.", "TMEM27 is a marker for beta cells.", "Mutations in G-Beta protein GNB1 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.", "Microcin J25 inhibits nucleoside triphosphate (NTP) binding.", "Gpr124 increases BBB breakdown in mouse models of ischemic stroke.", "Microcin J25 encourages nucleoside triphosphate (NTP) binding.", "ScPif1p has higher binding ability to G-rich ssDNA than to non-G-rich ssDNA.", "Gpr124 suppresses BBB breakdown in mouse models of ischemic stroke.", "The DdrB protein from Deinococcus radiodurans functions as a pentamer.", "ScPif1p has reduced binding ability to G-rich ssDNA compared to non-G-rich ssDNA."], "hard_negative": "Broadly HIV-1 Neutralizing Antibodies (bnAb) 10EB have no affinity for phospholipids."}
{"query_id": "196", "query_text": "C2 works synergistically with A-769662 to activate dephosphorylated AMPK.", "negative": "The first MBT repeat of the four malignant brain tumor (4MBT) domain of Drosophila's Sfmbt and of the orthologous mammalian L3MBTL2 is required for the interaction with the spacer region of Drosophila's Pleiohomeotic (Pho) or its human ortholog YY1.", "negatives": ["The first MBT repeat of the four malignant brain tumor (4MBT) domain of Drosophila's Sfmbt and of the orthologous mammalian L3MBTL2 is required for the interaction with the spacer region of Drosophila's Pleiohomeotic (Pho) or its human ortholog YY1.", "Rapamycin delays aging in fruit flies.", "Walking in traffic areas in London did not improve lung function in elderly adults.", "Oxidative DNA damage inhibits STING signalling.", "Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection increases dissemination of Salmonella Typhimurium from the gut.", "A diminished ovarian reserve is a very strong indicator of infertility, even in an a priori non-infertile population.", "Physical activity does not improve cognitive function in individuals with Alzheimers.", "High levels of CRP lead to a higher risk of exacerbations in chronic obstructive pulmonary disease (COPD).", "MT binding domain drives amyloid structure formation.", "Integrated care is ineffective at tackling multiple comorbidities."], "hard_negatives": ["C2 works synergistically with A-769662 to activate dephosphorylated AMPK.", "Reduced phosphorylation of PP2A increases HDAC4 dephosphorylation by enhancing PP2A-HDAC4 interaction.", "ITAM phosphorylation allows for the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).", "Reduced phosphorylation of PP2A suppresses HDAC4 dephosphorylation.", "Inhibiting glucose-6-phospate dehydrogenase improves lipogenesis by deactivating LKB1-AMPK signaling.", "AMP-activated protein kinase (AMPK) activation reduces inflammation-related fibrosis in the lungs.", "Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes fibrosis.", "Removal of H3K9me3 by ectopic expression of other H3K9 demethylases improves reprogramming efficiency in SCNT experiments.", "B3-Galectin increases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR.", "B3-Galectin decreases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR."], "hard_negative": "C2 works synergistically with A-769662 to activate dephosphorylated AMPK."}
{"query_id": "197", "query_text": "CCL19 is a ligand for CCR7.", "negative": "Forkhead 0 (fox0) transcription factors are involved in cellular differentiation.", "negatives": ["Forkhead 0 (fox0) transcription factors are involved in cellular differentiation.", "Natriuretic peptides increase susceptibility to diabetes.", "Inhibiting focal adhesion formation enables cells to convert mechanical strain into eventual scarring.", "Cancer-associated fibroblasts (CAFs) have no known interaction with cancer cells in the formation and activation of CAFs.", "Ribosomal protein (RP) expression is controlled in part by stress-activated regulators.", "Mutant mice lacking SVCT2 have severely reduced ascorbic acid levels in both brain and adrenals.", "Lamins are associated with nuclear membrane structure maintenance.", "76-85% of people with severe mental disorder receive no treatment in low and middle income countries.", "Ca2+ cycling is a UCP1-dependent thermogenic mechanism.", "In the UK, drowning affects boys and girls equally."], "hard_negatives": ["CCL19 is a ligand for CCR7.", "CCL19 is predominantly present within dLNs.", "L3MBTL2 binds to H2AK119Ub marked chromatin to form a PRC1 complex.", "The PRR MDA5 has a C-terminal domain.", "The PPR MDA5 has twenty N-terminal CARD domains.", "LRBA prevents CTLA - 4 recycling.", "Bcp1 is a chaperone for Rpl23.", "LRBA promotes CTLA - 4 recycling.", "The PDPN gene deactivates the C-type lectin receptor (CLEC-2).", "The predominant localization of Linc00173 is in mononuclear macrophage nuclei."], "hard_negative": "CCL19 is a ligand for CCR7."}
{"query_id": "199", "query_text": "CCL19 is predominantly present within dLNs.", "negative": "CCL19 is a ligand for CCR7.", "negatives": ["CCL19 is a ligand for CCR7.", "Carriers of HNF4A mutations are at reduced risk for diabetes.", "Reduction of Rpl38 alters the composition of the Hox gene mRNAs translation in mice without lowering overall protein synthesis.", "Cancer cells can stimulate the accumulation of intra-tumoural myeloid-derived suppressor cells by promoting granulocyte colony stimulating factor production.", "Ultrasound guidance significantly reduces the number of needle insertion attempts necessary for a given procedure.", "The morphology change from large white adipocytes to small brown adipocytes is a sign of increased energy expenditure potential in white adipose tissue.", "There was an estimated 30 million cases of pneumonia in young children worldwide in 2010.", "Major vault protein (MVP) leads to more aggressive tumors by regulating the sorting of tumor suppressive miR-193a into extracellular vesicles (EVs).", "Propriospinal interneurons that play a role in the plastic reorganization of spinal circuits are integral for recovery from spinal cord injury.", "Oxidative DNA damage activates STING signalling."], "hard_negatives": ["CCL19 is predominantly present within dLNs.", "CCL19 is a ligand for CCR7.", "The predominant localization of Linc00173 is in mononuclear macrophage nuclei.", "Cis-acting lncRNAs control the expression of genes that are positioned in the vicinity of their transcription sites.", "Bcp1 is a chaperone for Rpl23.", "LRBA prevents CTLA - 4 recycling.", "L3MBTL2 binds to H2AK119Ub marked chromatin to form a PRC1 complex.", "CDK6 shows improved binding to loss-of-function variants of p18 INK4C.", "Sn is present on mature DCs during inflammation in vivo.", "The PPR MDA5 has twenty N-terminal CARD domains."], "hard_negative": "CCL19 is predominantly present within dLNs."}
{"query_id": "200", "query_text": "CD28 initiates tonic signaling in conventional T cells, which causes an exhaustion phenotype and limited efficiency.", "negative": "Sweet taste receptors on the tongue are deactivated by between 1 and 10 mM glucose.", "negatives": ["Sweet taste receptors on the tongue are deactivated by between 1 and 10 mM glucose.", "Active H. pylori urease has a polymeric structure consisting of five distinct subunits.", "1-1% of colorectal cancer patients are diagnosed with regional or distant metastases.", "Excess gestational weight gain is associated with obesity-related pregnancy outcomes.", "Tumor development occurs in conjunction with upregulation of pro-inflammatory cytokines.", "Cardiac tissue-resident macrophages directly contribute to electrical activity.", "Ca2+ cycling controls whole-body energy homeostasis in beige fat.", "The cytokine receptor which regulates chemotaxis and formation of lymph nodes is involved in production of myeloperoxidase in the left atrium.", "Many cytokines that are produced by cancer cells also contribute to carcinogenesis.", "De novo assembly of sequence data has fewer specific contigs than unassembled sequence data."], "hard_negatives": ["CD28 initiates tonic signaling in conventional T cells, which causes an exhaustion phenotype and limited efficiency.", "CD28 signals regulate trafficking of murine auto-reactive T cells into target tissues.", "Major antigen-induced signals from the T cell receptor and secondary signals from costimulatory receptors are required for T cell activation.", "IL-10 production by monocytes inhibits CD4 + T cell response.", "Type 1 Diabetes is associated with subtle perturbations in T reg development.", "Peroxynitrite is required for induction of T cell tolerance.", "ITAM phosphorylation allows for the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).", "Activated Cdk5 phosphorylates the ATM protein in response to DNA damage.", "Reduced responsiveness to interleukin-2 in regulatory T cells is associated with autoimmune diseases such as Type 1 Diabetes.", "Activated Cdk5 regulates DNA damage-induced neuronal death."], "hard_negative": "CD28 initiates tonic signaling in conventional T cells, which causes an exhaustion phenotype and limited efficiency."}
{"query_id": "201", "query_text": "CD28 signals regulate trafficking of murine auto-reactive T cells into target tissues.", "negative": "Upregulation of PD1 causes the downmodulation of Satb1.", "negatives": ["Upregulation of PD1 causes the downmodulation of Satb1.", "Monoclonal antibody targeting of N-cadherin inhibits growth.", "Urbanization is an important risk factor related to the transmission of dengue fever.", "Persistor cells are one reason for incomplete responses to Tyrosine kinase inhibitor (TKI) therapy in cancer patients.", "DRD1 proteins enable Pol V transcription in vivo.", "Mutations in G-Beta protein GNB1 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.", "Roughly 55% of women with chronic pelvic pain have no underlying pathology.", "The innate immune response struggles to remove small numbers of parasites.", "Stroke patients with prior use of direct oral anticoagulants have a higher risk of in-hospital mortality than stroke patients with prior use of warfarin.", "HOXB4 is a highly expressed component of cellular secretome from fetal liver cell populations."], "hard_negatives": ["CD28 signals regulate trafficking of murine auto-reactive T cells into target tissues.", "Major antigen-induced signals from the T cell receptor and secondary signals from costimulatory receptors are required for T cell activation.", "CD28 initiates tonic signaling in conventional T cells, which causes an exhaustion phenotype and limited efficiency.", "ITAM phosphorylation allows for the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).", "IL-10 production by monocytes inhibits CD4 + T cell response.", "T cell receptor /CD3 microdomains are required to induce the immunologic synapse.", "Foxp3 represses the expression of transcriptional regulators implicated in memory T cell development.", "Activated Cdk5 phosphorylates the ATM protein in response to DNA damage.", "Foxp3 enables the expression of transcriptional regulators implicated in memory T cell development.", "Reduced responsiveness to interleukin-2 in regulatory T cells is associated with autoimmune diseases such as Type 1 Diabetes."], "hard_negative": "CD28 signals regulate trafficking of murine auto-reactive T cells into target tissues."}
{"query_id": "203", "query_text": "CD44v6 is not associated with constitutive and reprogrammed cancer stem cells driving cancer metastasis.", "negative": "Cognitive behavioral therapy is an ineffective treatment for insomnia", "negatives": ["Cognitive behavioral therapy is an ineffective treatment for insomnia", "MICAL redox enzymes regulate actin dynamics.", "Monoclonal antibody targeting of N-cadherin encourages castration resistance.", "B3-Galectin decreases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR.", "Systemic immunosuppressive (IS) therapy increases the chance of cancer mortality in patients with inflammatory eye disease (IED)", "Obesity decreases life quality.", "The PRDM1 gene, when combined with the PRDM14 gene, plays an important role during primordial germ cell specification.", "Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes epithelial damage.", "Mice lacking Sirt1 in Sf1-expressing neurons have increased susceptibility to diet-induced obesity and insulin resistance.", "Inhibiting glucose-6-phospate dehydrogenase improves lipogenesis by deactivating LKB1-AMPK signaling."], "hard_negatives": ["CD44v6 is not associated with constitutive and reprogrammed cancer stem cells driving cancer metastasis.", "Activated Cdk5 regulates DNA damage-induced neuronal death.", "CDK6 shows impaired binding to loss-of-function variants of p18 INK4C.", "p16INK4A degradation is encoded by CDKN2A.", "CDK6 shows improved binding to loss-of-function variants of p18 INK4C.", "MEK inhibitors are effective treatments in RAS-driven mouse models of cancer.", "Activated Cdk5 phosphorylates the ATM protein in response to DNA damage.", "ALDH1 expression is associated with poorer prognosis for breast cancer primary tumors.", "Cancer-associated fibroblasts (CAFs) have no known interaction with cancer cells in the formation and activation of CAFs.", "GATA3 regulates self-renewal capacity in bone marrow hematopoietic stem cells."], "hard_negative": "CD44v6 is not associated with constitutive and reprogrammed cancer stem cells driving cancer metastasis."}
{"query_id": "204", "query_text": "CDK6 shows impaired binding to loss-of-function variants of p18 INK4C.", "negative": "Homozygous deletion of murine Sbds gene from osterix-expressing mesenchymal stem and progenitor cells (MPCs) induces oxidative stress.", "negatives": ["Homozygous deletion of murine Sbds gene from osterix-expressing mesenchymal stem and progenitor cells (MPCs) induces oxidative stress.", "T cell receptor /CD3 microdomains are required to induce the immunologic synapse.", "Gpr124 increases BBB breakdown in mouse models of ischemic stroke.", "Pseudogene PTENP1 encodes a transcript that regulates PTEN expression.", "The microtubule-dependent delivery and secretion of matrix metalloproteases (MMPs) is partially responsible for the disassembly of adhesion sites.", "Moderate consumption of candy and chocolate reduces the risk of cardiovascular disease (CVD).", "M. stadtmanae induces ASC speck formation in BlaER1 monocytes.", "British male students are bullied more than British female students.", "PrimPol degrades short DNA replication intermediates on the leading strand during DNA replication.", "Forkhead 0 (fox0) transcription factors are involved in apoptosis."], "hard_negatives": ["CDK6 shows impaired binding to loss-of-function variants of p18 INK4C.", "CDK6 shows improved binding to loss-of-function variants of p18 INK4C.", "p16INK4A degradation is encoded by CDKN2A.", "p16INK4A degradation is  linked to an abnormal wound response caused by the microinvasive step of advanced Oral Potentially Malignant Lesions (OPMLs).", "CD44v6 is not associated with constitutive and reprogrammed cancer stem cells driving cancer metastasis.", "Activated Cdk5 phosphorylates the ATM protein in response to DNA damage.", "Reduced phosphorylation of PP2A increases HDAC4 dephosphorylation by enhancing PP2A-HDAC4 interaction.", "Reduced phosphorylation of PP2A suppresses HDAC4 dephosphorylation.", "Gpr124 suppresses BBB breakdown in mouse models of ischemic stroke.", "The PPR MDA5 has twenty N-terminal CARD domains."], "hard_negative": "CDK6 shows impaired binding to loss-of-function variants of p18 INK4C."}
{"query_id": "205", "query_text": "CDK6 shows improved binding to loss-of-function variants of p18 INK4C.", "negative": "GATA3 regulates cell cycle progression in bone marrow hematopoietic stem cells.", "negatives": ["GATA3 regulates cell cycle progression in bone marrow hematopoietic stem cells.", "Pioglitazone use is significantly associated with an increased risk of prostate cancer.", "In the UK, drowning affects boys and girls equally.", "H4 G94P proteins suppress degradation of free histones via Rad53-dependent mechanisms.", "Many transmembrane receptors transmit signals by long-range conformational changes in the association of alpha-helices across the plasma membrane.", "Normal granulomas form in the presence of TNF in Zebrafish.", "Algerian physicians constitue the largest component of sub-Saharan Africa-trained physicians in the United States.", "Environmentally-induced senescence is mimicked in disease modeling by adding specific molecules to the culture system.", "Antidepressants increase the severity of migraines.", "The G34R/V mutation does not create a hypomethylated phenotype at the H3K36 histone."], "hard_negatives": ["CDK6 shows improved binding to loss-of-function variants of p18 INK4C.", "CDK6 shows impaired binding to loss-of-function variants of p18 INK4C.", "p16INK4A degradation is encoded by CDKN2A.", "p16INK4A degradation is  linked to an abnormal wound response caused by the microinvasive step of advanced Oral Potentially Malignant Lesions (OPMLs).", "CD44v6 is not associated with constitutive and reprogrammed cancer stem cells driving cancer metastasis.", "Reduced phosphorylation of PP2A increases HDAC4 dephosphorylation by enhancing PP2A-HDAC4 interaction.", "Reduced phosphorylation of PP2A suppresses HDAC4 dephosphorylation.", "The PPR MDA5 has twenty N-terminal CARD domains.", "Activated Cdk5 phosphorylates the ATM protein in response to DNA damage.", "Gpr124 suppresses BBB breakdown in mouse models of ischemic stroke."], "hard_negative": "CDK6 shows improved binding to loss-of-function variants of p18 INK4C."}
{"query_id": "209", "query_text": "CHOP is a general endoplasmic reticulum stress marker.", "negative": "Tonic signaling from the scFv prevents constitutive stimulation.", "negatives": ["Tonic signaling from the scFv prevents constitutive stimulation.", "Physical activity does not improve cognitive function in individuals with Alzheimers.", "The HSV-2 infection is typically asymptomatic.", "Increase of p62 in prostate tumor stroma results in defective autophagy.", "Mutant mice lacking SVCT2 have severely reduced ascorbic acid levels in both brain and adrenals.", "The deregulated and prolonged activation of monocytes improves inflammatory disease outcomes.", "Cancer-associated fibroblasts (CAFs) are constituents of tumor microenvironments", "Mice lacking Sirt1 in Sf1-expressing neurons have increased susceptibility to diet-induced obesity and insulin resistance.", "R2D2 stops miRNA production by increasing the selectivity of Dcr2 for long dsRNA.", "Reduction of purity of cytoplasmic membranes isolated from overexpressors is indicated by stronger spots for OmpF in 2D BN-PAGE gels."], "hard_negatives": ["CHOP is a general endoplasmic reticulum stress marker.", "BiP is a general endoplasmic reticulum stress marker.", "ATF4 is a general endoplasmic reticulum stress marker.", "4-PBA treatment decreases endoplasmic reticulum stress in response to general endoplasmic reticulum stress markers.", "4-PBA treatment raises endoplasmic reticulum stress in response to general endoplasmic reticulum stress markers.", "Ribosomal protein (RP) expression is controlled in part by stress-activated regulators.", "The Snf1 complex regulates carbon and energy metabolism in baker's yeast (Saccharomyces cerevisiae).", "EGR2 is important to myelination of the peripheral nervous system.", "Activation of PPM1D enhances p53 function.", "Binding of p53 to enhancer regions (p53BERs) regulates the activity of p53 transcription and cell cycle arrest through the production of p53-dependent eRNAs."], "hard_negative": "CHOP is a general endoplasmic reticulum stress marker."}
{"query_id": "210", "query_text": "COPI coatmer is involved in lipid homeostasis.", "negative": "The World Health Organization's (WHO) data collection process is biased downward by unequal selection of larger outbreaks.", "negatives": ["The World Health Organization's (WHO) data collection process is biased downward by unequal selection of larger outbreaks.", "Inhibiting glucose-6-phospate dehydrogenase improves lipogenesis by deactivating LKB1-AMPK signaling.", "Albendazole is used to treat soil-transmitted helminths.", "The latent infection of myeloid cells with human cytomegalovirus induces a number of changes in gene expression.", "Pure neural progenitor cell (NPC) populations can only be obtained from cell cultures that undergo passaging, filtration, or other isolation and cell sorting methods.", "Sequence conservation in gene regulatory regions between species is a poor predictor of conserved functionality.", "Upregulation of PD1 causes the downmodulation of Satb1.", "TNFAIP3 is a tumor enhancer in glioblastoma.", "Pyridostatin reduces proliferation of homologous recombination - defective cells.", "Sepsis related mortality has remained stable between 2009-2014."], "hard_negatives": ["COPI coatmer is involved in lipid homeostasis.", "COPI coatmer is involved in viral replication.", "Myelin sheaths are lipid-rich cellular structures.", "Lipopolysaccharides have an inflammation independent effect on kidney barrier function.", "ER-localized phosphatase Sac1 processes PI4P through coordination with OSBP and the endosome-localized protein sorting nexin 2.", "Active H. pylori urease has a polymeric structure consisting of five distinct subunits.", "The C-type lectin receptor (CLEC-2) rearranges the actin cytoskeleton in dendritic cells to promote efficient motility along stromal surfaces.", "MeCP2 influences the synaptic maturation of neurons.", "MICAL redox enzymes regulate actin dynamics.", "The RANK-RANK-Ligand (RANKL) pathway is involved in the development of Aire-expressing medullary thymic epithelial cells (mTECs)."], "hard_negative": "COPI coatmer is involved in lipid homeostasis."}
{"query_id": "211", "query_text": "COPI coatmer is involved in viral replication.", "negative": "Increased microtubule acetylation exacerbates LRRK2 Roc-COR domain mutation induced locomotor deficits.", "negatives": ["Increased microtubule acetylation exacerbates LRRK2 Roc-COR domain mutation induced locomotor deficits.", "Pre-mRNAs associated with spliceosomal components are less stable than unassociated splicing substrates.", "Prescribed exercise training improves quality of life.", "p16INK4A degradation is encoded by CDKN2A.", "The one-child policy has created a hospitable environment for female infants.", "mcm 5 s 2 U is required for proper decoding of NNR codons in eukaryotes.", "Binding of p53 to enhancer regions (p53BERs) regulates the activity of p53 transcription and cell cycle arrest through the production of p53-dependent eRNAs.", "Deleting Raptor increases G-CSF levels.", "Differentiation of progenitor cells to myeloid cells is skewed when insulin signaling is suppressed.", "7-day-old adult Caenorhabditis elegans exhibit approximately 5% of the learning capacity seen in 1-day old adults."], "hard_negatives": ["COPI coatmer is involved in viral replication.", "COPI coatmer is involved in lipid homeostasis.", "Commelina yellow mottle virus' (ComYMV) genome consists of 2140 baise pairs.", "Bcp1 is a chaperone for Rpl23.", "L3MBTL2 binds to H2AK119Ub marked chromatin to form a PRC1 complex.", "Active H. pylori urease has a polymeric structure consisting of five distinct subunits.", "BLM gene encodes RecQ-class DNA helicase.", "Commelina yellow mottle virus (ComYMV) has three typical badnavirus ORFs, capable of encoding proteins 23, 15, and 216 kD.", "Microcin J25 encourages nucleoside triphosphate (NTP) binding.", "The origin of the CRF01_1b2k protein occurred between 1923 and 1956."], "hard_negative": "COPI coatmer is involved in viral replication."}
{"query_id": "214", "query_text": "CRP is positively correlated with postoperative mortality following Coronary Artery Bypass Graft (CABG) surgery.", "negative": "Systemic immunosuppressive (IS) therapy does not enhance the chance of cancer mortality in patients with inflammatory eye disease (IED)", "negatives": ["Systemic immunosuppressive (IS) therapy does not enhance the chance of cancer mortality in patients with inflammatory eye disease (IED)", "The deregulated and prolonged activation of monocytes has deleterious effects in chronic infectious conditions.", "Stacking is more stable when a purine is present in the +5 position (C1698).", "Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes epithelial damage.", "Type 1 Diabetes is associated with subtle perturbations in T reg development.", "A T helper 2 cell (Th2) environment impedes disease development in patients with systemic lupus erythematosus (SLE).", "The removal of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells.", "siRNA knockdown of A20 accelerates tumor progression in an in vivo murine xenograft model.", "Monoclonal antibody targeting of N-cadherin inhibits growth.", "Vaccinating the gastrointestinal tract induces protection of rectal and vaginal mucosa."], "hard_negatives": ["CRP is positively correlated with postoperative mortality following Coronary Artery Bypass Graft (CABG) surgery.", "High levels of CRP lead to a higher risk of exacerbations in chronic obstructive pulmonary disease (COPD).", "Diabetic patients with acute coronary syndrome experience decreased short-term and long-term risk for bleeding events.", "Decreased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm.", "Increased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm.", "Sudden death can occur in patients with orthostatic hypertension without cardiac conduction abnormalities.", "Risk of cardiovascular events can be cut by a third by using antihypertensive drug therapy among hemodialysis patients.", "32% of liver transplantation programs required patients to discontinue methadone treatment in 2001.", "Systemic lupus erythematosus is a risk factor for cardiovascular disease.", "Sudden death can occur in patients with complex ventricular arrhythmias."], "hard_negative": "CRP is positively correlated with postoperative mortality following Coronary Artery Bypass Graft (CABG) surgery."}
{"query_id": "220", "query_text": "Ca2+ cycling controls whole-body energy homeostasis in beige fat.", "negative": "An M2-like phenotype in brown adipose tissue macrophages is quickly induced by cold exposure.", "negatives": ["An M2-like phenotype in brown adipose tissue macrophages is quickly induced by cold exposure.", "Normal expression of RUNX1 causes tumorsupressing effects.", "RANK-RANKL pathway signalling is linked to development of Aire-expressing medullary thymic epithelial cells.", "A high microerythrocyte count protects against severe anemia in homozygous alpha (+)- thalassemia trait subjects.", "Deregulation of HAND2 is a crucial step in endometrial carcinogenesis in mice.", "Replacement of histone H2A with H2A.Z accelerates gene activation in yeasts by destabilizing +1 nucleosomes.", "Pyridostatin stabilizes the G - quadruplex in the telomeric region.", "A strong bias in the phage genome locations where the spacers were derived has been observed in many CRISPR subtypes that confer the immunity to phage.", "KLF4 is necessary for VSMCs to gain genetic characteristics of other cell types within atherosclerotic lesions.", "Antimicrobial agents are less effective due to the pressure of antimicrobial usage."], "hard_negatives": ["Ca2+ cycling controls whole-body energy homeostasis in beige fat.", "Ca2+ cycling is a UCP1-dependent thermogenic mechanism.", "Ca2+ cycling is a UCP1-independent thermogenic mechanism.", "The M2-phenotype in brown adipose tissue macrophages increases brown adipose tissue thermogenic activity.", "The morphology change from large white adipocytes to small brown adipocytes is a sign of increased energy expenditure potential in white adipose tissue.", "The morphology change from large white adipocytes to small brown adipocytes is a sign of decreased energy expenditure potential in white adipose tissue.", "The appearance of brown-like or beige cells primarily occurs in visceral fat, not subcutaneous fat.", "Healthy volunteers exhibit rapid and transient increase of cellular ATP after being bolus-injected with fructose.", "Mitochondria play a trivial role in calcium homeostasis.", "MFGE8 regulates fat absorption by binding to av-Beta3 and av-Beta5 integrins."], "hard_negative": "Ca2+ cycling controls whole-body energy homeostasis in beige fat."}
{"query_id": "221", "query_text": "Ca2+ cycling is a UCP1-dependent thermogenic mechanism.", "negative": "p75 NTR - associated cell death executor (NADE) interacts with the p75 NTR death domain", "negatives": ["p75 NTR - associated cell death executor (NADE) interacts with the p75 NTR death domain", "KRT17 modulates the expression of the transcriptional regulator AIRE in diseased epithelia.", "General exercise therapy is more effective than scapular stabilizer exercises in reducing pain and improving function of the shoulder.", "BiP is a general endoplasmic reticulum stress marker.", "Most termination events in Okazaki fragments are dictated by initiation patterns.", "Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 inhibit West Nile virus replication in cortical neurons.", "Lack of FGF21 in mice leads to atherosclerotic plaque formation.", "Kir7.1 modulates channel activity by the G protein-coupled melanocortin-4 receptor (MC4R) in the paraventricular nucleus of the hypothalamus.", "Healthy volunteers exhibit rapid and transient increase of cellular ATP after being bolus-injected with fructose.", "Anthrax spores remain deadly until affected areas are decontaminated."], "hard_negatives": ["Ca2+ cycling is a UCP1-dependent thermogenic mechanism.", "Ca2+ cycling is a UCP1-independent thermogenic mechanism.", "Ca2+ cycling controls whole-body energy homeostasis in beige fat.", "The M2-phenotype in brown adipose tissue macrophages increases brown adipose tissue thermogenic activity.", "Mitochondria play a trivial role in calcium homeostasis.", "The Snf1 complex regulates carbon and energy metabolism in baker's yeast (Saccharomyces cerevisiae).", "Oxidative phosphorylation is one of the primary glycometabolic pathways in cells.", "Ethanol stress increases the expression of IBP in bacteria.", "Osteocytes have an essential role in G-CSF induced HSPC mobilization.", "MeCP2 influences the synaptic maturation of neurons."], "hard_negative": "Ca2+ cycling is a UCP1-dependent thermogenic mechanism."}
{"query_id": "222", "query_text": "Ca2+ cycling is a UCP1-independent thermogenic mechanism.", "negative": "In rhesus macaques, daily subcutaneous injections of tenofovir protects against rectally transmitted simian-human immunodeficiency virus.", "negatives": ["In rhesus macaques, daily subcutaneous injections of tenofovir protects against rectally transmitted simian-human immunodeficiency virus.", "CRP is positively correlated with postoperative mortality following Coronary Artery Bypass Graft (CABG) surgery.", "Pyridostatin deregulates G2/M progression.", "Mitochondria play a major role in apoptosis.", "\u03b2-sheet opening occurs during pleurotolysin pore formation.", "Removal of H3K9me3 by ectopic expression of other H3K9 demethylases decreases reprogramming efficiency in SCNT experiments.", "TRAP+ osteoclasts regulate mature osteoblast maintenance.", "A 100g dose of chloroquine chemoprophylactic regimen results in retinal toxicity after 5-6 years of weekly intake.", "TNFAIP3 is a glioblastoma tumor suppressor.", "Repressing IL-18 has negative effects on atherosclerotic lesion composition and progression."], "hard_negatives": ["Ca2+ cycling is a UCP1-dependent thermogenic mechanism.", "Ca2+ cycling is a UCP1-independent thermogenic mechanism.", "Ca2+ cycling controls whole-body energy homeostasis in beige fat.", "The M2-phenotype in brown adipose tissue macrophages increases brown adipose tissue thermogenic activity.", "Mitochondria play a trivial role in calcium homeostasis.", "The Snf1 complex regulates carbon and energy metabolism in baker's yeast (Saccharomyces cerevisiae).", "Ethanol stress increases the expression of IBP in bacteria.", "Oxidative phosphorylation is one of the primary glycometabolic pathways in cells.", "Osteocytes have an essential role in G-CSF induced HSPC mobilization.", "Activation of the Rac1 homolog CED-10 kills viable cells in SRGP-1 mutant Caenorhabditis elegans."], "hard_negative": "Ca2+ cycling is a UCP1-dependent thermogenic mechanism."}
{"query_id": "223", "query_text": "Cancer cells can stimulate the accumulation of intra-tumoural myeloid-derived suppressor cells by promoting granulocyte colony stimulating factor production.", "negative": "Acute ablation of Snail in the embryonic cortex affects the proliferation and number of embryonic cortical precursors.", "negatives": ["Acute ablation of Snail in the embryonic cortex affects the proliferation and number of embryonic cortical precursors.", "Increased flux of microbial products suppresses immune responses.", "Aggravated inflammation is dependent on NLRP3 inflammasome activation.", "A mutation in HNF4A leads to an increased risk of diabetes by the age of 14 years.", "Deletion of ATM and Rad3 related protein is not predictive of acute tissue loss.", "Surfactin producing cells and exopolymer producing cells cooperate to generate \"Van Gogh\" bundles that have sliding abilities on specialized media.", "M. stadtmanae does not induce ASC speck formation in BlaER1 monocytes.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have decreased risk for dementia.", "PRC1-bound plasmids sediment at a slower rate in unbound plasmids than in sucrose gradients.", "Cholesterol loading induces KLF4 expression in VSMCs, resulting in the expression of pro-inflammatory cytokines."], "hard_negatives": ["Cancer cells can stimulate the accumulation of intra-tumoural myeloid-derived suppressor cells by promoting granulocyte colony stimulating factor production.", "Cancer-associated fibroblasts (CAFs) interact with cancer cells to mediate formation and activation of CAFs.", "Cancer-associated fibroblasts (CAFs) have no known interaction with cancer cells in the formation and activation of CAFs.", "Cancer-associated fibroblasts (CAFs) are constituents of tumor microenvironments", "Differentiation of progenitor cells to myeloid cells is skewed when insulin signaling is suppressed.", "Differentiation of progenitor cells to myeloid cells is skewed upon activation of insulin signaling.", "Glioblastoma multiforme (GBM) is characterized by extensive invasion, rapid growth, necrosis, and angiogenesis.", "The cytokine receptor which regulates chemotaxis and formation of lymph nodes is involved in production of myeloperoxidase in the left atrium.", "Induced hepatic stem cells possess the potential to differentiate into cholangiocytic cells.", "Many cytokines that are produced by cancer cells also contribute to carcinogenesis."], "hard_negative": "Cancer cells can stimulate the accumulation of intra-tumoural myeloid-derived suppressor cells by promoting granulocyte colony stimulating factor production."}
{"query_id": "224", "query_text": "Cancer-associated fibroblasts (CAFs) are constituents of tumor microenvironments", "negative": "cSMAC formation represses weak ligand signalling.", "negatives": ["cSMAC formation represses weak ligand signalling.", "Post-transcriptional handling of mitochondrial transcripts occurs in mitochondrial RNA granules.", "Human embryonic stem cells give rise to cell types from all three embryonic germ layers.", "During the primary early antibody response activated B cells migrate toward the inner-and outer follicular areas where oxysterol accumulation is generated by stromal cells.", "Foxp3 enables the expression of transcriptional regulators implicated in memory T cell development.", "CHOP is a general endoplasmic reticulum stress marker.", "Acute ablation of KRAS causes severe growth impairment.", "Low nucleosome occupancy correlates with high methylation levels across species.", "RTEL1 interacts with TRF2 through a C4C4 motif", "ART substantially reduces infectiveness of HIV-positive people."], "hard_negatives": ["Cancer-associated fibroblasts (CAFs) are constituents of tumor microenvironments", "Cancer-associated fibroblasts (CAFs) interact with cancer cells to mediate formation and activation of CAFs.", "Cancer-associated fibroblasts (CAFs) have no known interaction with cancer cells in the formation and activation of CAFs.", "Glioblastoma multiforme (GBM) is characterized by extensive invasion, rapid growth, necrosis, and angiogenesis.", "Cancer cells can stimulate the accumulation of intra-tumoural myeloid-derived suppressor cells by promoting granulocyte colony stimulating factor production.", "Microglia are an innate immune cell type of the central nervous system.", "Microglia are an innate immune cell type of the peripheral nervous system.", "Fibroblast Growth Factor is a ligand which signals through receptor tyrosine kinases.", "Cancers that initially benefit from epidermal growth factor receptor targeted therapies later become refractory through several mechanisms.", "Flexible molecules experience less steric hindrance in the tumor microenviroment than rigid molecules."], "hard_negative": "Cancer-associated fibroblasts (CAFs) are constituents of tumor microenvironments"}
{"query_id": "225", "query_text": "Cancer-associated fibroblasts (CAFs) have no known interaction with cancer cells in the formation and activation of CAFs.", "negative": "Commelina yellow mottle virus (ComYMV) has three typical badnavirus ORFs, capable of encoding proteins 23, 15, and 216 kD.", "negatives": ["Commelina yellow mottle virus (ComYMV) has three typical badnavirus ORFs, capable of encoding proteins 23, 15, and 216 kD.", "ER-localized phosphatase Sac1 processes PI4P through coordination with OSBP and the endosome-localized protein sorting nexin 2.", "Medications to treat obesity are highly effective.", "Systemic immunosuppressive (IS) therapy does not enhance the chance of cancer mortality in patients with inflammatory eye disease (IED)", "Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection increases dissemination of Salmonella Typhimurium from the gut.", "Tonic signaling from the scFv is amplified by MyD88/CD40.", "The proportion of people with visual difficulty is two times higher in low-income countries than in high-income countries.", "Egr3 regulates the homeostasis of B and T cells.", "Taking 400mg of \u03b1-tocopheryl acetate in combination with vitamin C reduces the risk of prostate cancer.", "Chinese individuals with TT homozygosity in the MTHFR gene are less vulnerable to strokes caused by low levels of folate intake."], "hard_negatives": ["Cancer-associated fibroblasts (CAFs) interact with cancer cells to mediate formation and activation of CAFs.", "Cancer-associated fibroblasts (CAFs) have no known interaction with cancer cells in the formation and activation of CAFs.", "Cancer-associated fibroblasts (CAFs) are constituents of tumor microenvironments", "Cancer cells can stimulate the accumulation of intra-tumoural myeloid-derived suppressor cells by promoting granulocyte colony stimulating factor production.", "Many cytokines that are produced by cancer cells also contribute to carcinogenesis.", "Glioblastoma multiforme (GBM) is characterized by extensive invasion, rapid growth, necrosis, and angiogenesis.", "Fibroblast Growth Factor is a ligand which signals through receptor tyrosine kinases.", "Microglia are an innate immune cell type of the central nervous system.", "Microglia are an innate immune cell type of the peripheral nervous system.", "Cancers that initially benefit from epidermal growth factor receptor targeted therapies later become refractory through several mechanisms."], "hard_negative": "Cancer-associated fibroblasts (CAFs) interact with cancer cells to mediate formation and activation of CAFs."}
{"query_id": "226", "query_text": "Cancer-associated fibroblasts (CAFs) interact with cancer cells to mediate formation and activation of CAFs.", "negative": "Cognitive behavioral therapy is an ineffective treatment for insomnia", "negatives": ["Cognitive behavioral therapy is an ineffective treatment for insomnia", "AMP-activated protein kinase (AMPK) activation reduces inflammation-related fibrosis in the lungs.", "Suboptimal nutrition is a leading cause of premature death", "The generation of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells.", "50% of patients exposed to radiation have activated markers of mesenchymal stem cells.", "Addition of BMP4, activin A, CHIR99021, and SU504 to reprogramming fibroblasts generates, expands and maintains cardiovascular progenitor cells (CPCs)", "GATA3 regulates cell cycle progression in bone marrow hematopoietic stem cells.", "Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission.", "M. stadtmanae does not induce ASC speck formation in BlaER1 monocytes.", "32% of liver transplantation programs required patients to discontinue methadone treatment in 2001."], "hard_negatives": ["Cancer-associated fibroblasts (CAFs) interact with cancer cells to mediate formation and activation of CAFs.", "Cancer-associated fibroblasts (CAFs) have no known interaction with cancer cells in the formation and activation of CAFs.", "Cancer-associated fibroblasts (CAFs) are constituents of tumor microenvironments", "Fibroblast Growth Factor is a ligand which signals through receptor tyrosine kinases.", "Cancer cells can stimulate the accumulation of intra-tumoural myeloid-derived suppressor cells by promoting granulocyte colony stimulating factor production.", "Many cytokines that are produced by cancer cells also contribute to carcinogenesis.", "Microglia are an innate immune cell type of the central nervous system.", "Microglia are an innate immune cell type of the peripheral nervous system.", "Glioblastoma multiforme (GBM) is characterized by extensive invasion, rapid growth, necrosis, and angiogenesis.", "Pro-inflammatory cytokines are up regulated during tumor development."], "hard_negative": "Cancer-associated fibroblasts (CAFs) interact with cancer cells to mediate formation and activation of CAFs."}
{"query_id": "227", "query_text": "Cancers that initially benefit from epidermal growth factor receptor targeted therapies later become refractory through several mechanisms.", "negative": "The deamination of cytidine to uridine on the minus strand of viral DNA can inactivate the viral genome by inducing G-to-A mutations.", "negatives": ["The deamination of cytidine to uridine on the minus strand of viral DNA can inactivate the viral genome by inducing G-to-A mutations.", "Chlamydia trachomatis is most prevalent in the UK among sexually-experienced individuals aged 16 to 24.", "Rising temperatures caused by global warming increases risk of dengue fever transmission.", "Long chain polyunsaturated fatty acids supplementation has no significant effects on wheezing or asthma at 3 and 6 years.", "Origin gross domestic product(GDP) is negatively related to dengue virus (DENV-1) diffusion in air traffic shipments.", "Mice are incapable of producing neutralizing antibodies in reponse to the Chikungunya virus (CHIKV) produced in mosquitos.", "Increased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm.", "Ca2+ cycling is a UCP1-dependent thermogenic mechanism.", "Guanine nucleotide exchange factors (GEFs) mediate RhoA activation in response to tensional forces on fibronectin-binding integrins.", "Rapamycin delays aging in fruit flies."], "hard_negatives": ["Cancers that initially benefit from epidermal growth factor receptor targeted therapies later become refractory through several mechanisms.", "Many cytokines that are produced by cancer cells also contribute to carcinogenesis.", "Cancer-associated fibroblasts (CAFs) interact with cancer cells to mediate formation and activation of CAFs.", "Cancer-associated fibroblasts (CAFs) are constituents of tumor microenvironments", "Cancer-associated fibroblasts (CAFs) have no known interaction with cancer cells in the formation and activation of CAFs.", "Upon developing tyrosine-kinase inhibitor resistance, new mutations in epidermal growth factor receptors emerge and cause treatment failure.", "Nonsteroidal antinflammatory drugs are ineffective as cancer treatments.", "MEK inhibitors are effective treatments in RAS-driven mouse models of cancer.", "Environmental factors can influence the development of breast cancer.", "Up-regulation of the p53 pathway and related molecular events speeds cancer progression."], "hard_negative": "Cancers that initially benefit from epidermal growth factor receptor targeted therapies later become refractory through several mechanisms."}
{"query_id": "228", "query_text": "Cardiac tissue-resident macrophages directly contribute to electrical activity.", "negative": "Pioneer factor OCT3/4 interacts with major chromatin remodeling factors.", "negatives": ["Pioneer factor OCT3/4 interacts with major chromatin remodeling factors.", "Pyridostatin stabilizes the G - quadruplex in the telomeric region.", "Crossover hot spots are found within gene promoters in Saccharomyces cerevisiae.", "HNF4A mutations are associated with macrosomia in infancy.", "Weighed food records (WFR) result in poor completion since they're costly to run and impose high participant burden.", "Intramembrane cleavage by signal peptide peptidase aids in the degradation of proteins with a complex membrane orientation.", "Carriers of HNF4A mutations are at reduced risk for diabetes.", "In melanoma, anti-CTLA-4 treatment reinvigorates exhausted PD-1+Eomes+CD8 T cells.", "Notch signaling occurs between tumor cells and stromal cells.", "Bcp1 is a chaperone for Rpl23."], "hard_negatives": ["Cardiac tissue-resident macrophages directly contribute to electrical activity.", "The myocardial cell lineage originally develops from cardiac progenitors of exclusively endodermal origin.", "Mitochondria play a major role in energy production.", "Adult tissue-resident macrophages possess a self-renewing capacity.", "Bone marrow cells don't contribute to adult macrophage compartments.", "The cytokine receptor which regulates chemotaxis and formation of lymph nodes is involved in production of myeloperoxidase in the left atrium.", "Nuclear transfer from adult human fibroblasts to human oocytes can give rise to blastocysts containing expandable pluripotent cells.", "Mitochondria play a trivial role in calcium homeostasis.", "Tirasemtiv targets cardiac muscle.", "AMP-activated protein kinase (AMPK) activation reduces inflammation-related fibrosis in the lungs."], "hard_negative": "Cardiac tissue-resident macrophages directly contribute to electrical activity."}
{"query_id": "229", "query_text": "Carriers of HNF4A mutations are at reduced risk for diabetes.", "negative": "The density of cytokine receptor bearing cells affects the distance over which cytokines act.", "negatives": ["The density of cytokine receptor bearing cells affects the distance over which cytokines act.", "Amitriptyline is an effective treatment for chronic tension-type headaches.", "Ca2+ cycling is a UCP1-independent thermogenic mechanism.", "Active Ly49Q induces neutrophil polarization.", "Addition of BMP4, activin A, CHIR99021, and SU504 to reprogramming fibroblasts generates, expands and maintains cardiovascular progenitor cells (CPCs)", "The relationship between a breast cancer patient's capacity to metabolize tamoxifen and treatment outcome is independent of the patient's genetic make-up.", "Ribosomopathies have a high degree of cell and tissue specific pathology.", "Neutrophil extracellular trap (NET) antigens may contain the targeted autoantigens PR3 and MPO.", "Antimicrobial agents are more effective due to the pressure of antimicrobial usage.", "\u03b2-sheet opening occurs during pleurotolysin pore formation."], "hard_negatives": ["Carriers of HNF4A mutations are at reduced risk for diabetes.", "HNF4A mutations are associated with macrosomia in infancy.", "There is no association between HNF4A mutations and diabetes risks.", "A mutation in HNF4A leads to an increased risk of developing diabetes by the age of 14 years.", "A mutation in HNF4A leads to an increased risk of diabetes by the age of 14 years.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have decreased risk for dementia.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have increased risk for Alzheimer's disease.", "A deficiency of vitamin B12 decreases blood levels of homocysteine.", "The generation of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells.", "The removal of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells."], "hard_negative": "Carriers of HNF4A mutations are at reduced risk for diabetes."}
{"query_id": "235", "query_text": "Cell autonomous sex determination in somatic cells occurs in Galliformes.", "negative": "The HSV-2 infection is typically asymptomatic.", "negatives": ["The HSV-2 infection is typically asymptomatic.", "Polymeal nutrition increases cardiovascular mortality.", "The first MBT repeat of the four malignant brain tumor (4MBT) domain of Drosophila's Sfmbt and of the orthologous mammalian L3MBTL2 is required for the interaction with the spacer region of Drosophila's Pleiohomeotic (Pho) or its human ortholog YY1.", "HAND2 methylation is a key step in early endometrial carcinogenesis.", "Hypocretin neurones suppress panicprone state in rats.", "The effect of Lipopolysaccharides on kidney barrier function is dependent on inflammation levels.", "Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection decreases dissemination of Salmonella Typhimurium from the gut.", "Ribosome-inactivating protein-2 (RIP-2) interacts with the p75 NTR death domain", "General exercise therapy is more effective than scapular stabilizer exercises in reducing pain and improving function of the shoulder.", "Genes involved in pre-mRNA splicing have a significant impact on genome stability."], "hard_negatives": ["Cell autonomous sex determination in somatic cells occurs in Galliformes.", "The number of unfertilized oocytes in mated hermaphrodites increases with age.", "The proliferative capacity of progenitors is regulated cell-autonomously.", "Mitochondria play a major role in apoptosis.", "Cellular differentiation of embryonic stem cells is accompanied by changes in replication timing, transcription and nuclear localization.", "Human embryonic stem cells have the capacity to give rise to differentiated progeny representative of all three embryonic germ layers.", "Inside the body, falciparum parasites reproduce asexually.", "Cellular clocks are not predictive of mitosis timing in NIH 3T3 cells.", "Human embryonic stem cells give rise to cell types from all three embryonic germ layers.", "Cellular clocks are associated with mitosis timing in NIH 3T3 cells."], "hard_negative": "Cell autonomous sex determination in somatic cells occurs in Galliformes."}
{"query_id": "241", "query_text": "Cellular clocks are associated with mitosis timing in NIH 3T3 cells.", "negative": "The microtubule-dependent delivery and secretion of matrix metalloproteases (MMPs) is partially responsible for the disassembly of adhesion sites.", "negatives": ["The microtubule-dependent delivery and secretion of matrix metalloproteases (MMPs) is partially responsible for the disassembly of adhesion sites.", "Students who perform poorly in the early years of medical school are less likely to commit professional misconduct later in their careers.", "Crossover hot spots are found within gene promoters in Saccharomyces cerevisiae.", "Converting apoE4 to apoE3 by gene editing prevents the pathology associated with apoE4 in human iPSCderived neurons.", "Mutations in RIM1 decrease levels of IME1 RNA.", "Nigerian physicians constitue the largest component of sub-Saharan Africa-trained physicians in the United States.", "Ly49Q directs the organization of neutrophil polarization by regulating membrane raft functions.", "76-85% of people with severe mental disorder receive no treatment in low and middle income countries.", "CRP is positively correlated with postoperative mortality following Coronary Artery Bypass Graft (CABG) surgery.", "DMS3 protein enables Pol V transcription in vivo."], "hard_negatives": ["Cellular clocks are associated with mitosis timing in NIH 3T3 cells.", "Cellular clocks are not predictive of mitosis timing in NIH 3T3 cells.", "Mitochondria play a major role in energy production.", "Mitochondria play a major role in apoptosis.", "Mitochondria play a trivial role in calcium homeostasis.", "Cellular differentiation of embryonic stem cells is accompanied by changes in replication timing, transcription and nuclear localization.", "Foxp3 enables the expression of transcriptional regulators implicated in memory T cell development.", "The Snf1 complex regulates carbon and energy metabolism in baker's yeast (Saccharomyces cerevisiae).", "Long - range chromatin interactions regulate transcription.", "Foxp3 represses the expression of transcriptional regulators implicated in memory T cell development."], "hard_negative": "Cellular clocks are associated with mitosis timing in NIH 3T3 cells."}
{"query_id": "242", "query_text": "Cellular clocks are not predictive of mitosis timing in NIH 3T3 cells.", "negative": "Activation of PPM1D enhances p53 function.", "negatives": ["Activation of PPM1D enhances p53 function.", "Activated Cdk5 phosphorylates the ATM protein in response to DNA damage.", "Microglia are an innate immune cell type of the peripheral nervous system.", "Glycan adaptation is rarely observed in the B-cell repertoire.", "FoxO3a activation in neuronal death is inhibited by reactive oxygen species (ROS).", "Adult tissue-resident macrophages are seeded before birth.", "Less than 10% of patients exposed to radiation have activated markers of mesenchymal stem cells.", "CHOP is a general endoplasmic reticulum stress marker.", "BRCA 1 mutation carriers' risk of breast and ovarian cancer depends on where the mutation is located.", "The one-child policy has created a hospitable environment for female infants."], "hard_negatives": ["Cellular clocks are not predictive of mitosis timing in NIH 3T3 cells.", "Cellular clocks are associated with mitosis timing in NIH 3T3 cells.", "Mitochondria play a major role in energy production.", "Mitochondria play a major role in apoptosis.", "Mitochondria play a trivial role in calcium homeostasis.", "Cellular differentiation of embryonic stem cells is accompanied by changes in replication timing, transcription and nuclear localization.", "Cyclin A2 destruction is necessary to switch from unstable to stable kt-mt attachments in mitosis.", "Recognition of start codons depends on the translation initiation factor IF3.", "The Snf1 complex regulates carbon and energy metabolism in baker's yeast (Saccharomyces cerevisiae).", "Foxp3 represses the expression of transcriptional regulators implicated in memory T cell development."], "hard_negative": "Cellular clocks are not predictive of mitosis timing in NIH 3T3 cells."}
{"query_id": "243", "query_text": "Cellular differentiation of embryonic stem cells is accompanied by changes in replication timing, transcription and nuclear localization.", "negative": "At least 85% of patients exposed to radiation have activated markers of myofibroblasts.", "negatives": ["At least 85% of patients exposed to radiation have activated markers of myofibroblasts.", "A deficiency of vitamin B12 decreases blood levels of homocysteine.", "Diminished ovarian reserve is a reliable indicator of infertility in a non-infertile population.", "eRNAs influence is linked to senescence, aging, and carcinogenesis.", "ITAM phosphorylation allows for the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).", "Incidence of sepsis has fallen substantially from 2009 to 2014.", "L3MBTL2 binds to H2AK119Ub marked chromatin to form a PRC1 complex.", "Inhibiting HDAC6 increases survival of mice with ARID1A mutated tumors.", "Normal expression of RUNX1 causes tumorsupressing effects.", "B cells go though plasmablast differentiation and antibody production by continuous expression of EBI2."], "hard_negatives": ["Cellular differentiation of embryonic stem cells is accompanied by changes in replication timing, transcription and nuclear localization.", "Human embryonic stem cells have the capacity to give rise to differentiated progeny representative of all three embryonic germ layers.", "Human embryonic stem cells give rise to cell types from the outer embryonic germ layer, but not the other two layers.", "Human embryonic stem cells give rise to cell types from all three embryonic germ layers.", "Long - range chromatin interactions regulate transcription.", "Differentiation of progenitor cells to myeloid cells is skewed upon activation of insulin signaling.", "Nuclear transfer from adult human fibroblasts to human oocytes can give rise to blastocysts containing expandable pluripotent cells.", "Understanding epigenetic regulation of replication is essential for the reational design of episomally replicating vectors.", "Up-regulation of the p53 pathway and related molecular events speeds cancer progression.", "Genes involved in pre-mRNA splicing have a significant impact on genome stability."], "hard_negative": "Cellular differentiation of embryonic stem cells is accompanied by changes in replication timing, transcription and nuclear localization."}
{"query_id": "244", "query_text": "Certain immunomodulator-human dialyzable leukocyte extract (hDLE) peptides are recognized by toll-like receptors (TLRs) on macrophages and dendritic cells.", "negative": "Removal of H3K9me3 improves reprogramming efficiency in human somatic cell nuclear transfer experiments.", "negatives": ["Removal of H3K9me3 improves reprogramming efficiency in human somatic cell nuclear transfer experiments.", "The microtubule-dependent delivery and secretion of matrix metalloproteases (MMPs) is partially responsible for the disassembly of adhesion sites.", "Reduction of purity of cytoplasmic membranes isolated from overexpressors is indicated by stronger spots for OmpA in 2D BN-PAGE gels.", "ATM and Rad3 related protein are critical for sensing DNA damage.", "Rhythmic expression of Cry1 translates directly into a circadian regulation of cAMP signaling in gluconeogenesis.", "In British Men, haplogroup I decreases risk of cardiovascular disease.", "Energy balance requires hypothalamic glutamate neurotransmission.", "The PPR MDA5 has twenty N-terminal CARD domains.", "Natriuretic peptides protect against diabetes.", "HOXB4 is a highly expressed component of cellular secretome from fetal liver cell populations."], "hard_negatives": ["Certain immunomodulator-human dialyzable leukocyte extract (hDLE) peptides are recognized by toll-like receptors (TLRs) on macrophages and dendritic cells.", "Toll-like receptor (TLR) signaling is involved in the pathogenesis of human MDS.", "Blocking the interaction between TDP-43 and respiratory complex I proteins ND3 and ND6 prevents TDP-43-induced neuronal loss.", "CD28 signals regulate trafficking of murine auto-reactive T cells into target tissues.", "The NF-\u03baB essential modulator gene induces intestinal inflammation by promoting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death.", "ITAM phosphorylation allows for the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).", "Repressing IL-18 has negative effects on atherosclerotic lesion composition and progression.", "The NF-\u03baB essential modulator gene prevents intestinal inflammation by inhibiting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death.", "Eilat virus (EILV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in nonhuman primates.", "EG7 tumors can be killed by systemic oxaliplatin primed CD8+ T cells from the tumor-draining lymph node cells."], "hard_negative": "Certain immunomodulator-human dialyzable leukocyte extract (hDLE) peptides are recognized by toll-like receptors (TLRs) on macrophages and dendritic cells."}
{"query_id": "245", "query_text": "Charcoal is an effective treatment for acute paraquat poisoning.", "negative": "Hypothalamic glutamate neurotransmission is unrelated to energy balance.", "negatives": ["Hypothalamic glutamate neurotransmission is unrelated to energy balance.", "Mice defective for deoxyribonucleic acid (DNA) polymerase m (polm) reveal increased sensitivity to ionizing radiation (IR).", "The tip of the inner tube of the toxic type VI secretion system (T6SS) antibacterial effector in Escherichia coli (E. coli) is decorated with VgrG and PAAR proteins.", "PrimPol degrades short DNA replication intermediates on the leading strand during DNA replication.", "A country's Vaccine Alliance (GAVI) eligibility is not indictivate of accelerated adoption of the Hub vaccine.", "Ly49Q directs the organization of neutrophil polarization by regulating membrane raft functions.", "Rhythmic expression of Cry1 translates directly into a circadian regulation of cAMP signaling in gluconeogenesis.", "Incidence of 10/66 dementia is lower than the incidence of DSM-IV dementia.", "Increased flux of microbial products provokes immune responses.", "ER-localized phosphatase Sac1 processes PI4P through coordination with OSBP and the endosome-localized protein sorting nexin 2."], "hard_negatives": ["Charcoal is an effective treatment for acute paraquat poisoning.", "Charcoal shows no benefit for acute paraquat poisoning.", "Gastric lavage is an effective treatment for acute paraquat poisoning.", "Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission.", "Anthrax spores remain deadly until affected areas are decontaminated.", "High levels of CRP lead to a higher risk of exacerbations in chronic obstructive pulmonary disease (COPD).", "Anthrax spores are very difficult to dispose once they are dispersed.", "Gastric infection with Helicobacter pylori increases risk of gastric cancer in humans.", "Gastric infection with Helicobacter pylori decreases risk of gastric cancer in humans.", "Higher plasma levels of I-carnitine, when associated with trimethylamine N-oxide, are negatively correlated with cardiovascular events in humans."], "hard_negative": "Charcoal is an effective treatment for acute paraquat poisoning."}
{"query_id": "246", "query_text": "Charcoal shows no benefit for acute paraquat poisoning.", "negative": "Bone Marrow (BM) transplantation is used to treat acute myeloid leukemia (AML)", "negatives": ["Bone Marrow (BM) transplantation is used to treat acute myeloid leukemia (AML)", "Epidemiological disease burden from noncommunicable diseases is more prevalent in high economic settings.", "Two variants of chromosome 6q21 are associated with radiation therapy-induced second malignancies in pediatric Hodgkin lymphoma patients.", "High levels of CRP lead to a higher risk of exacerbations in chronic obstructive pulmonary disease (COPD).", "COPI coatmer is involved in viral replication.", "Microglia are an innate immune cell type of the peripheral nervous system.", "Lamins are associated with nuclear membrane structure maintenance.", "Over half of the gabonese children with Schimmelpenning-Feuerstein-Mims syndrome (SFM) had a plasma lactate of more than 5mmol/L.", "NR5A2 is important in reverse cholesterol transport in humans.", "Replacement of histone H2A with H2A.Z accelerates gene activation in yeasts by destabilizing +1 nucleosomes."], "hard_negatives": ["Charcoal shows no benefit for acute paraquat poisoning.", "Charcoal is an effective treatment for acute paraquat poisoning.", "Gastric lavage is an effective treatment for acute paraquat poisoning.", "High levels of CRP lead to a higher risk of exacerbations in chronic obstructive pulmonary disease (COPD).", "Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission.", "Anthrax spores remain deadly until affected areas are decontaminated.", "There is no increased risk of hypospadias with clomiphene.", "Gastric infection with Helicobacter pylori increases risk of gastric cancer in humans.", "Higher plasma levels of I-carnitine, when associated with trimethylamine N-oxide, are negatively correlated with cardiovascular events in humans.", "Gastric infection with Helicobacter pylori decreases risk of gastric cancer in humans."], "hard_negative": "Charcoal shows no benefit for acute paraquat poisoning."}
{"query_id": "247", "query_text": "Chemical injury represses transglutaminase 2 activity.", "negative": "Mutations in G-Beta protein GNB1 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.", "negatives": ["Mutations in G-Beta protein GNB1 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.", "ER-localized phosphatase Sac1 processes PI4P through coordination with OSBP and the endosome-localized protein sorting nexin 2.", "Including pharmacists in rounding teams does not alter the incidence of adverse drug events (ADEs).", "Mouse models can be generated using \"artificial spermatids.\"", "Ambulatory blood pressure monitoring is inaccurate at diagnosing hypertension.", "Marmosets have a brain region homologous to Broca's area.", "Intake of folic acid (FA) and vitamin B6 (VB6) reduces levels of homocysteine.", "A high microerythrocyte count protects against severe anemia in homozygous alpha (+)- thalassemia trait subjects.", "Chronic HIV stimulation of B cells leads to the premature exhaustion of B cells.", "BCL-2 activation antagonizes the apoptotic effects of c-Myc."], "hard_negatives": ["Chemical injury represses transglutaminase 2 activity.", "Physical injury represses transgultaminase activity.", "The deamination of cytidine to uridine on the minus strand of viral DNA can inactivate the viral genome by inducing G-to-A mutations.", "A deficiency of vitamin B12 decreases blood levels of homocysteine.", "Ethanol stress increases the expression of IBP in bacteria.", "Autophagy deficiency in the liver increases vulnerability to insulin resistance.", "A deficiency of folate increases blood levels of homocysteine.", "Neutrophils produce IL-1\u03b2 in response to large particles.", "Immune complex triggered cell death leads to sequestration of oxidized mitochondrial DNA.", "Oxidative phosphorylation is one of the primary glycometabolic pathways in cells."], "hard_negative": "Chemical injury represses transglutaminase 2 activity."}
{"query_id": "250", "query_text": "Chenodeoxycholic acid treatment decreases brown adipose tissue activity.", "negative": "Deltex has no known interactions with eIF3f.", "negatives": ["Deltex has no known interactions with eIF3f.", "There is no relation between Erythromycin use and hypertrophic pyloric stenosis.", "General exercise therapy is more effective than rotator cuff exercises in reducing pain and improving function of the shoulder.", "BCL-2 promotes the apoptotic effects of c-Myc.", "Cholesterol loading induces KLF4 expression in VSMCs, resulting in the expression of pro-inflammatory cytokines.", "TNFAIP3 is a glioblastoma tumor suppressor.", "APOE4 expression in iPSC-derived neurons results in decreased tau phosphorylation.", "APOE4 expression in iPSC-derived neurons results in decreased tau phosphorylation.", "Scapular stabilizer exercises are more effective than general exercise therapy in reducing pain and improving function of the shoulder.", "Adult tissue-resident macrophages stem from the embryonal yolk sac and fetal liver."], "hard_negatives": ["Chenodeoxycholic acid treatment decreases brown adipose tissue activity.", "Chenodeoxycholic acid treatment increases brown adipose tissue activity.", "The M2-phenotype in brown adipose tissue macrophages increases brown adipose tissue thermogenic activity.", "The morphology change from large white adipocytes to small brown adipocytes is a sign of decreased energy expenditure potential in white adipose tissue.", "The morphology change from large white adipocytes to small brown adipocytes is a sign of increased energy expenditure potential in white adipose tissue.", "Reduced levels of lipolysis leads to higher P38 phosphorylation in adipose tissue.", "Increased lipolysis leads to higher P38 phosphorylation in adipose tissue.", "An M2-like phenotype in brown adipose tissue macrophages is quickly induced by cold exposure.", "Ca2+ cycling controls whole-body energy homeostasis in beige fat.", "PCSK9 inhibitors decrease plasma Lp(a) levels."], "hard_negative": "Chenodeoxycholic acid treatment decreases brown adipose tissue activity."}
{"query_id": "251", "query_text": "Chenodeoxycholic acid treatment increases brown adipose tissue activity.", "negative": "The DEXI promoter region is bound by multiple transcription factors in a murine haematopoietic progenitor cell line.", "negatives": ["The DEXI promoter region is bound by multiple transcription factors in a murine haematopoietic progenitor cell line.", "ALDH1 expression is associated with poorer prognosis for breast cancer primary tumors.", "Pioglitazone use is not associated with an increased risk of prostate cancer.", "Understanding epigenetic regulation of replication is essential for the reational design of episomally replicating vectors.", "Inhibiting focal adhesion formation enables cells to convert mechanical strain into eventual scarring.", "Tirasemtiv targets cardiac muscle.", "Expression of MSX2 is induced 3 hours after the addition of BMP4, which is earlier than T and CDX2.", "Differentiated E2f-1, -2, -3 TKO cells in the intestine do not exhibit apoptosis.", "siRNA knockdown of A20 accelerates tumor progression in an in vivo murine xenograft model.", "The density of cytokine receptor bearing cells affects the distance over which cytokines act."], "hard_negatives": ["Chenodeoxycholic acid treatment increases brown adipose tissue activity.", "Chenodeoxycholic acid treatment decreases brown adipose tissue activity.", "The M2-phenotype in brown adipose tissue macrophages increases brown adipose tissue thermogenic activity.", "Increased lipolysis leads to higher P38 phosphorylation in adipose tissue.", "The morphology change from large white adipocytes to small brown adipocytes is a sign of increased energy expenditure potential in white adipose tissue.", "The morphology change from large white adipocytes to small brown adipocytes is a sign of decreased energy expenditure potential in white adipose tissue.", "Reduced levels of lipolysis leads to higher P38 phosphorylation in adipose tissue.", "An M2-like phenotype in brown adipose tissue macrophages is quickly induced by cold exposure.", "Ca2+ cycling controls whole-body energy homeostasis in beige fat.", "Inhibiting glucose-6-phospate dehydrogenase improves lipogenesis by deactivating LKB1-AMPK signaling."], "hard_negative": "Chenodeoxycholic acid treatment increases brown adipose tissue activity."}
{"query_id": "253", "query_text": "Chinese individuals with TT homozygosity in the MTHFR gene are less vulnerable to strokes caused by low levels of folate intake.", "negative": "Long chain polyunsaturated fatty acids supplementation is associated with lower rates of atopic eczema at 1 year.", "negatives": ["Long chain polyunsaturated fatty acids supplementation is associated with lower rates of atopic eczema at 1 year.", "Lamins have no effect on nuclear membrane structure maintenance.", "Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes fibrosis.", "DUSP4 decreases apoptosis.", "Pre-mRNAs associated with spliceosomal components are more stable than unassociated splicing substrates.", "Rising temperatures caused by global warming increases risk of dengue fever transmission.", "Gastric lavage is an effective treatment for acute paraquat poisoning.", "5'-nucleotidase metabolizes 6MP.", "Pioneer factor OCT3/4 interacts with major chromatin remodeling factors.", "HNF4A mutations are associated with macrosomia in infancy."], "hard_negatives": ["Chinese individuals with TT homozygosity in the MTHFR gene are more vulnerable to strokes caused by low levels of folate intake.", "Chinese individuals with TT homozygosity in the MTHFR gene are less vulnerable to strokes caused by low levels of folate intake.", "A deficiency of folate increases blood levels of homocysteine.", "Intake of folic acid (FA) and vitamin B6 (VB6) reduces levels of homocysteine.", "High levels of CRP lead to a higher risk of exacerbations in chronic obstructive pulmonary disease (COPD).", "Intake of folic acid (FA) and vitamin B6 (VB6) increases levels of homocysteine.", "40mg/day dosage of folic acid and 2mg/day dosage of vitamin B12 does not affect chronic kidney disease (CKD) progression.", "Mice lacking Sirt1 in Sf1-expressing neurons have increased susceptibility to diet-induced obesity and insulin resistance.", "Exercise reduces cancer mortality rates among Chinese citizens.", "Exercise increases cancer mortality rates among Chinese citizens."], "hard_negative": "Chinese individuals with TT homozygosity in the MTHFR gene are more vulnerable to strokes caused by low levels of folate intake."}
{"query_id": "254", "query_text": "Chinese individuals with TT homozygosity in the MTHFR gene are more vulnerable to strokes caused by low levels of folate intake.", "negative": "Sn is present on mature DCs during inflammation in vivo.", "negatives": ["Sn is present on mature DCs during inflammation in vivo.", "Individuals with low serum vitamin D concentrations have decreased risk of multiple sclerosis.", "Low nucleosome occupancy correlates with high methylation levels across species.", "\u03b2-sheet opening occurs during pleurotolysin pore formation.", "EGR2 is important to myelination of the peripheral nervous system.", "Most termination events in Okazaki fragments are dictated by initiation patterns.", "Tuberculosis-induced granulomas express different immune system protein signatures than the surrounding tissue.", "DUSP4 decreases apoptosis.", "Pharmacist attendance at ward rounds increases adverse events in wards.", "The DdrB protein from Deinococcus radiodurans functions as a pentamer."], "hard_negatives": ["Chinese individuals with TT homozygosity in the MTHFR gene are more vulnerable to strokes caused by low levels of folate intake.", "Chinese individuals with TT homozygosity in the MTHFR gene are less vulnerable to strokes caused by low levels of folate intake.", "A deficiency of folate increases blood levels of homocysteine.", "Intake of folic acid (FA) and vitamin B6 (VB6) reduces levels of homocysteine.", "High levels of CRP lead to a higher risk of exacerbations in chronic obstructive pulmonary disease (COPD).", "Intake of folic acid (FA) and vitamin B6 (VB6) increases levels of homocysteine.", "Mice lacking Sirt1 in Sf1-expressing neurons have increased susceptibility to diet-induced obesity and insulin resistance.", "40mg/day dosage of folic acid and 2mg/day dosage of vitamin B12 does not affect chronic kidney disease (CKD) progression.", "Exercise reduces cancer mortality rates among Chinese citizens.", "Exercise increases cancer mortality rates among Chinese citizens."], "hard_negative": "Chinese individuals with TT homozygosity in the MTHFR gene are more vulnerable to strokes caused by low levels of folate intake."}
{"query_id": "255", "query_text": "Chlamydia trachomatis is most prevalent in the UK among individuals in their 50s and 60s.", "negative": "CD44v6 is not associated with constitutive and reprogrammed cancer stem cells driving cancer metastasis.", "negatives": ["CD44v6 is not associated with constitutive and reprogrammed cancer stem cells driving cancer metastasis.", "A T helper 2 cell (Th2) environment impedes disease development in patients with systemic lupus erythematosus (SLE).", "Ultrasound guidance significantly reduces the number of traumatic procedures when attempting needle insertion.", "Bone Marrow (BM) transplantation is used to treat acute myeloid leukemia (AML)", "Primary cervical cancer screening with HPV detection has lower longitudinal sensitivity than conventional cytology to detect cervical intraepithelial neoplasia grade 2.", "IFIT1 speeds viral replication by allowing for the proliferation of mis-capped viral RNAs.", "Medications to treat obesity do not have side effects.", "Neutrophil extracellular trap (NET) antigens may contain the targeted autoantigens PR3 and MPO.", "siRNA knockdown of A20 slows tumor progression in an in vivo murine xenograft model.", "Polymeal nutrition increases cardiovascular mortality."], "hard_negatives": ["Chlamydia trachomatis is most prevalent in the UK among individuals in their 50s and 60s.", "Chlamydia trachomatis is most prevalent in the UK among sexually-experienced individuals aged 16 to 24.", "Tuberculosis incidence occurs at higher rates in more sparsely populated areas in the UK.", "Incidence of 10/66 dementia is lower than the incidence of DSM-IV dementia.", "Incidence of 10/66 dementia is higher than the incidence of DSM-IV dementia.", "Ten percent (10%) of kidney cancers in the UK are attributable to excess weight.", "Approximately 250,000 people are infected with human T-cell lymphotropic virus type 1 in the United Kingdom.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have decreased risk for dementia.", "In the UK, drowning affects boys and girls equally.", "Incidence of sepsis has fallen substantially from 2009 to 2014."], "hard_negative": "Chlamydia trachomatis is most prevalent in the UK among individuals in their 50s and 60s."}
{"query_id": "256", "query_text": "Chlamydia trachomatis is most prevalent in the UK among sexually-experienced individuals aged 16 to 24.", "negative": "Distant CREs are important for transcriptional regulation.", "negatives": ["Distant CREs are important for transcriptional regulation.", "Chenodeoxycholic acid treatment increases brown adipose tissue activity.", "Oxidative phosphorylation is one of the primary glycometabolic pathways in cells.", "Hypocretin neurones suppress panicprone state in rats.", "In transgenic mice harboring green florescent protein under the control of the Sox2 promoter, more than 50 percent of the cells with green florescent colocalize with cell proliferation markers.", "Mice that lack Interferon-\u03b3 or its receptor are highly susceptible to experimental autoimmune myocarditis.", "ATM and Rad3 related protein are critical for sensing DNA damage.", "In British Men, haplogroup I decreases risk of cardiovascular disease.", "Distant CREs are important for transcriptional regulation.", "Crossover hot spots are found within gene promoters in Saccharomyces cerevisiae."], "hard_negatives": ["Chlamydia trachomatis is most prevalent in the UK among sexually-experienced individuals aged 16 to 24.", "Chlamydia trachomatis is most prevalent in the UK among individuals in their 50s and 60s.", "Sildenafil worsens erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.", "In the UK, drowning affects boys and girls equally.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have decreased risk for dementia.", "The peak incidence of fractures occurs during pubertal growth spurt in early adolescents.", "Bacterial meningitis can be diagnosed on the basis of positive cerebrospinal fluid (CSF) cultures.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have shorter lifetime exposure to estrogen due to a decreased reproductive period.", "The peak incidence of fractures occurs in toddlers.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have longer lifetime exposure to estrogen due to an increased reproductive period."], "hard_negative": "Chlamydia trachomatis is most prevalent in the UK among sexually-experienced individuals aged 16 to 24."}
{"query_id": "258", "query_text": "Cholesterol loading induces KLF4 expression in VSMCs, resulting in the expression of pro-inflammatory cytokines.", "negative": "Microcin J25 inhibits nucleoside triphosphate (NTP) binding.", "negatives": ["Microcin J25 inhibits nucleoside triphosphate (NTP) binding.", "A strong bias in the phage genome locations where the spacers were derived has been observed in many CRISPR subtypes that confer the immunity to phage.", "Deletion of ATM and Rad3 related protein is not predictive of acute tissue loss.", "Cyclin A2 destruction is necessary to switch from unstable to stable kt-mt attachments in mitosis.", "The HSV-2 infection is typically asymptomatic.", "HOXB4 is a highly expressed component of cellular secretome from fetal liver cell populations.", "Carriers of HNF4A mutations are at reduced risk for diabetes.", "Birth-weight is negatively associated with breast cancer.", "Metastatic colorectal cancer treated with a single agent fluoropyrimidines resulted in similar efficacy and better quality of life when compared with oxaliplatin-based chemotherapy in elderly patients.", "DMS3 protein enables Pol V transcription in vivo."], "hard_negatives": ["Cholesterol loading induces KLF4 expression in VSMCs, resulting in the expression of pro-inflammatory cytokines.", "Primary pro-inflammatory cytokines suppress secondary pro- and anti-inflammatory mediators.", "KLF4 is necessary for VSMCs to gain genetic characteristics of other cell types within atherosclerotic lesions.", "Pro-inflammatory cytokines are up regulated during tumor development.", "Tumor development occurs in conjunction with upregulation of pro-inflammatory cytokines.", "The cytokine receptor which regulates chemotaxis and formation of lymph nodes is involved in production of myeloperoxidase in the left atrium.", "Pro-inflammatory cytokines are up repressed during tumor development.", "Tumor development occurs in conjunction with suppression of pro-inflammatory cytokines.", "CD28 signals regulate trafficking of murine auto-reactive T cells into target tissues.", "The density of cytokine receptor bearing cells has no effect on the distance over which cytokines act."], "hard_negative": "Cholesterol loading induces KLF4 expression in VSMCs, resulting in the expression of pro-inflammatory cytokines."}
{"query_id": "259", "query_text": "Chronic HIV stimulation of B cells leads to the premature exhaustion of B cells.", "negative": "Eilat virus (EILV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in nonhuman primates.", "negatives": ["Eilat virus (EILV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in nonhuman primates.", "Mice defective for deoxyribonucleic acid (DNA) polymerase m (polm) reveal increased sensitivity to ionizing radiation (IR).", "The number of unfertilized oocytes in mated hermaphrodites increases with age.", "Commelina yellow mottle virus (ComYMV) has three typical badnavirus ORFs, capable of encoding proteins 23, 15, and 216 kD.", "Insulin decreases risk of severe kidney failure.", "Chinese individuals with TT homozygosity in the MTHFR gene are less vulnerable to strokes caused by low levels of folate intake.", "Gpr124 increases BBB breakdown in mouse models of ischemic stroke.", "RUNX1 is downregulated or mutated in TLX1 T-ALL.", "Taxation of sugar-sweetened beverages reduced the incidence rate of type II diabetes in India.", "Lamins are found within the inner layer of the nuclear membrane of all cells."], "hard_negatives": ["Chronic HIV stimulation of B cells leads to the premature exhaustion of B cells.", "Exhaustion of B cells contributes to poor Ab response in HIV-infected individuals.", "Antiretroviral therapy increases rates of tuberculosis across a broad range of CD4 strata.", "Having a main partner worsens HIV outcomes.", "Patients in stable partnerships progress from HIV to death at the same rate as patients not in partnerships.", "Tuberculosis-induced granulomas express different immune system protein signatures than the surrounding tissue.", "Rising temperatures caused by global warming increases risk of dengue fever transmission.", "Rising temperatures caused by global warming lowers the risk of dengue fever transmission.", "A low percentage of hematopoietic progenitor cells are susceptible to HIV-1 infection ex vivo.", "The deregulated and prolonged activation of monocytes has deleterious effects in chronic infectious conditions."], "hard_negative": "Chronic HIV stimulation of B cells leads to the premature exhaustion of B cells."}
{"query_id": "262", "query_text": "Cis-acting lncRNAs control the expression of genes that are positioned in the vicinity of their transcription sites.", "negative": "The generation of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells.", "negatives": ["The generation of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells.", "Self-advocacy training is effective at decreasing homelessness.", "There is a positive correlation between hip fractures and statin use.", "Deltex interacts with eIF3. There is no known interaction between Deltex and elF3", "Perigenital skin is not the primary site of HIV acquisition.", "Beta-band coherence is enhanced for visible stimuli over invisible stimuli.", "Suboptimal nutrition is a leading cause of premature death", "Thiopurine active metabolites can be catabolized through dephosphorylation of thioguanine nucleotides.", "Mice without IFN-\u03b3 or its receptor are highly susceptible to EAM induced with \u03b1-MyHC/CFA.", "Albendazole is used to treat soil-transmitted helminths."], "hard_negatives": ["Cis-acting lncRNAs control the expression of genes that are positioned in the vicinity of their transcription sites.", "Trans-acting factors, such as lncRNAs, influence mRNA translation.", "Long - range chromatin interactions regulate transcription.", "Distant CREs are important for transcriptional regulation.", "CCL19 is predominantly present within dLNs.", "Concentrations of SNV and CNV in stem-cell regulatory elements and binding sites of transcription factors in iPSC-lines are distinct from their founding cells.", "miRNAs enforce homeostasis by suppressing low-level ''leaky'' transcription.", "Lamins are found within the inner layer of the nuclear membrane of all cells.", "Lamins are associated with nuclear membrane structure maintenance.", "JMJD6 catalyzes the hydroxylation of C-terminal lysine and supresses transcriptional activity."], "hard_negative": "Cis-acting lncRNAs control the expression of genes that are positioned in the vicinity of their transcription sites."}
{"query_id": "263", "query_text": "Citrullinated proteins externalized in neutrophil extracellular traps act indirectly to disrupt the inflammatory cycle.", "negative": "DRD1 proteins enable Pol V transcription in vivo.", "negatives": ["DRD1 proteins enable Pol V transcription in vivo.", "Increased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm.", "Microcin J25 encourages nucleoside triphosphate (NTP) binding.", "Cellular clocks are not predictive of mitosis timing in NIH 3T3 cells.", "Vitamin D is an important factor in the relationship between calcium and parathyroid hormone.", "The DEXI promoter region is bound by multiple transcription factors in a murine haematopoietic progenitor cell line.", "The DESMOND program demonstrates no significant impact on weight loss.", "Mice defective for deoxyribonucleic acid (DNA) polymerase I (polI) fail to reveal increased sensitivity to ionizing radiation (IR).", "miRNAs enforce homeostasis by suppressing low-level ''leaky'' transcription.", "R2D2 stops miRNA production by increasing the selectivity of Dcr2 for long dsRNA."], "hard_negatives": ["Citrullinated proteins externalized in neutrophil extracellular traps act indirectly to disrupt the inflammatory cycle.", "Citrullinated proteins externalized in neutrophil extracellular traps act indirectly to perpetuate the inflammatory cycle via induction of autoantibodies.", "Neutrophils produce IL-1\u03b2 in response to large particles.", "Inhibiting focal adhesion formation increases the rate at which cells convert mechanical strain into inflammation and fibrosis.", "Neutrophil extracellular trap (NET) antigens may contain the targeted autoantigens PR3 and MPO.", "The tissue surrounding the granuloma in an immune cell induces an anti-inflammatory immune response.", "Enhanced early production of inflammatory chemokines damages viral control in the lung.", "Tuberculosis-induced granulomas express different immune system protein signatures than the surrounding tissue.", "Ethanol stress increases the expression of SRL in bacteria.", "Primary pro-inflammatory cytokines suppress secondary pro- and anti-inflammatory mediators."], "hard_negative": "Citrullinated proteins externalized in neutrophil extracellular traps act indirectly to disrupt the inflammatory cycle."}
{"query_id": "264", "query_text": "Citrullinated proteins externalized in neutrophil extracellular traps act indirectly to perpetuate the inflammatory cycle via induction of autoantibodies.", "negative": "British male students are bullied more than British female students.", "negatives": ["British male students are bullied more than British female students.", "Replacement of histone H2A with H2A.Z accelerates gene activation in yeasts by destabilizing +1 nucleosomes.", "Depletion of nitric oxide is responsible for vasospasm.", "Glucose restriction to 0.05% reduces RLS (replicative life span) by 20-40% in S. cerevisiae.", "The RANK-RANK-Ligand (RANKL) pathway is involved in the development of Aire-expressing medullary thymic epithelial cells (mTECs).", "Reducing H3k4me3 methylation induces mouse epiblast stem cells to naive pluripotency efficiently.", "Inside the body, falciparum parasites reproduce asexually.", "Decreased conversion of PGE 2 to PPARy ligand 15-ket-PGE 2 causes accumulation of PGE.", "The DESMOND program demonstrates no significant impact on lifestyles outcomes.", "Microcin J25 inhibits nucleoside triphosphate (NTP) binding."], "hard_negatives": ["Citrullinated proteins externalized in neutrophil extracellular traps act indirectly to perpetuate the inflammatory cycle via induction of autoantibodies.", "Citrullinated proteins externalized in neutrophil extracellular traps act indirectly to disrupt the inflammatory cycle.", "Neutrophils produce IL-1\u03b2 in response to large particles.", "Enhanced early production of inflammatory chemokines damages viral control in the lung.", "During the primary early antibody response activated B cells migrate toward the inner-and outer follicular areas where oxysterol accumulation is generated by stromal cells.", "Primary pro-inflammatory cytokines suppress secondary pro- and anti-inflammatory mediators.", "Neutrophil extracellular trap (NET) antigens may contain the targeted autoantigens PR3 and MPO.", "Helicobacter pylori-induced aberrant NF-kB-dependent expression of activation-induced cytidine deaminase contributes to the mutagenesis of host DNA.", "Upon viral challenge, influenza-specific memory CD4+ T cells greatly diminish the early production of inflammatory chemokines in the lung.", "Oxidative DNA damage activates STING signalling."], "hard_negative": "Citrullinated proteins externalized in neutrophil extracellular traps act indirectly to perpetuate the inflammatory cycle via induction of autoantibodies."}
{"query_id": "265", "query_text": "Clathrin stabilizes the spindle fiber apparatus during mitosis.", "negative": "ScPif1p has higher binding ability to G-rich ssDNA than to non-G-rich ssDNA.", "negatives": ["ScPif1p has higher binding ability to G-rich ssDNA than to non-G-rich ssDNA.", "There is no known interaction between Pioneer factor OCT3/4 and major chromatin remodeling factors.", "Rapid phosphotransfer rates are correlated with histidine kinase regulator specificity.", "Ribosomal protein (RP) expression is controlled in part by stress-activated regulators.", "Systemic immunosuppressive (IS) therapy does not enhance the chance of cancer mortality in patients with inflammatory eye disease (IED)", "In S. cerevisiae, the absence of RNA surveillance pathways causes sensitivity to high iron conditions.", "Glycan adaptation involves insertion-deletion events.", "Cancer cells can stimulate the accumulation of intra-tumoural myeloid-derived suppressor cells by promoting granulocyte colony stimulating factor production.", "Cancer cells can stimulate the accumulation of intra-tumoural myeloid-derived suppressor cells by promoting granulocyte colony stimulating factor production.", "Side effects associated with antidepressants increases risk of stroke."], "hard_negatives": ["Clathrin stabilizes the spindle fiber apparatus during mitosis.", "PrimPol generates short DNA replication intermediates on the leading strand during DNA replication.", "Mitochondria play a major role in energy production.", "Inhibiting focal adhesion formation increases the rate at which cells convert mechanical strain into inflammation and fibrosis.", "Lamins have no effect on nuclear membrane structure maintenance.", "Mitochondria play a major role in apoptosis.", "PrimPol degrades short DNA replication intermediates on the leading strand during DNA replication.", "Mitochondria play a trivial role in calcium homeostasis.", "Lamins are found within the inner layer of the nuclear membrane of all cells.", "The microtubule-dependent delivery and secretion of matrix metalloproteases (MMPs) is partially responsible for the disassembly of adhesion sites."], "hard_negative": "Clathrin stabilizes the spindle fiber apparatus during mitosis."}
{"query_id": "266", "query_text": "Cnn1 recruitment varies with cell cycle timing.", "negative": "Toll-like receptor (TLR) signaling is involved in the pathogenesis of human MDS.", "negatives": ["Toll-like receptor (TLR) signaling is involved in the pathogenesis of human MDS.", "Pediatric SCD patients with vaso-occlusive crisis show increased morphine use after breathing 80 ppm iNO for 4 hours.", "Patients with common epithelial cancers  are more likely to have an emergency event as their first hospital admission if they live in resource-deprived areas.", "Osteocytes have an essential role in G-CSF induced HSPC mobilization.", "B3-Galectin increases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR.", "Lmna knock-in models are appropriate for testing therapeutic approaches against Hutchinson-Gilford progeria syndrome (HGPS).", "Lice attenuated SIV vaccines induce a stronger antigen-specific T cell response in lymph node cells.", "Ethanol stress lowers the expression of PSP in bacteria.", "B3-Galectin increases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have shorter lifetime exposure to estrogen due to a decreased reproductive period."], "hard_negatives": ["Cnn1 recruitment varies with cell cycle timing.", "Lack of FGF21 in mice increases life expectancy.", "Recognition of start codons depends on the translation initiation factor IF3.", "Lack of FGF21 in mice leads to reduced lifespan.", "The proliferative capacity of neural progenitors differs across species.", "Cellular differentiation of embryonic stem cells is accompanied by changes in replication timing, transcription and nuclear localization.", "Understanding epigenetic regulation of replication is essential for the reational design of episomally replicating vectors.", "Dscam1 acts as a hypervariable pattern-recognition receptor for the immune system.", "Forkhead 0 (fox0) transcription factors are involved in cellular differentiation.", "Ly49Q directs the organization of neutrophil polarization by regulating membrane raft functions."], "hard_negative": "Cnn1 recruitment varies with cell cycle timing."}
{"query_id": "267", "query_text": "Cognitive behavioral therapy is an ineffective treatment for insomnia", "negative": "CDK6 shows impaired binding to loss-of-function variants of p18 INK4C.", "negatives": ["CDK6 shows impaired binding to loss-of-function variants of p18 INK4C.", "0-dimensional biomaterials lack inductive properties.", "Satellite cell dysfunction is a key factor in sarcopenia development.", "Tumor development occurs in conjunction with upregulation of pro-inflammatory cytokines.", "Ethanol stress increases the expression of IBP in bacteria.", "Increase of p62 in prostate tumor stroma results in defective autophagy.", "Cholesterol loading induces KLF4 expression in VSMCs, resulting in the expression of pro-inflammatory cytokines.", "Vaccinating the gastrointestinal tract induces protection of rectal and vaginal mucosa.", "7-day-old adult Caenorhabditis elegans exhibit approximately 75% of the learning capacity seen in 1-day old adults.", "Reducing H3k4me3 methylation induces mouse epiblast stem cells to naive pluripotency efficiently."], "hard_negatives": ["Cognitive behavioral therapy is an ineffective treatment for insomnia", "Headaches are correlated with cognitive impairment.", "Antidepressants reduce the severity of migraines.", "Side effects associated with antidepressants increases risk of stroke.", "In young and middle-aged adults, current or remote uses of ADHD medications increase the risk of serious cardiovascular events.", "Antidepressants increase the severity of migraines.", "Sildenafil worsens erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.", "Side effects associated with antidepressants do not represent a mortality risk to postmenopausal women.", "Patients with panic anxiety show decreased CSF levels of hypocretin.", "Amitriptyline is an effective treatment for chronic tension-type headaches."], "hard_negative": "Cognitive behavioral therapy is an ineffective treatment for insomnia"}
{"query_id": "272", "query_text": "Combination nicotine replacement therapies with varenicline or bupropion are more effective after 12 weeks of reatment compared to varenicline monotherapy.", "negative": "The H2A-H2B eviction defect is compensated for by other histone chaperone(s).", "negatives": ["The H2A-H2B eviction defect is compensated for by other histone chaperone(s).", "Vitamin D is an important factor in the relationship between calcium and parathyroid hormone.", "RUNX1 is downregulated or mutated in TLX1 T-ALL.", "Men are more susceptible to death due to pneumonia when compared to women.", "Transcription factor EB induces transcription of pro-inflammatory cytokines in macrophages infected with Staphylococcus aureus.", "Up-regulation of the p53 pathway and related molecular events speeds cancer progression.", "The generation of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells.", "Whole brain radiotherapy increases the occurrence of new brain metastases.", "ATM and Rad3 related protein are critical for sensing DNA damage.", "Pioglitazone use is significantly associated with an increased risk of prostate cancer."], "hard_negatives": ["Combination nicotine replacement therapies with varenicline or bupropion are more effective after 12 weeks of reatment compared to varenicline monotherapy.", "Varenicline monotherapy is more effective after 26 weeks of treatment compared to combination nicotine replacement therapies with varenicline or bupropion.", "Side effects associated with antidepressants do not represent a mortality risk to postmenopausal women.", "Side effects associated with antidepressants increases risk of stroke.", "Sildenafil worsens erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.", "Antiretroviral therapy increases rates of tuberculosis across a broad range of CD4 strata.", "Stroke patients with prior use of direct oral anticoagulants have a higher risk of in-hospital mortality than stroke patients with prior use of warfarin.", "Side effects associated with antidepressants lower risk of myocardial infarction.", "Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission.", "A 100g dose of chloroquine chemoprophylactic regimen results in retinal toxicity after 1 year of weekly intake."], "hard_negative": "Combination nicotine replacement therapies with varenicline or bupropion are more effective after 12 weeks of reatment compared to varenicline monotherapy."}
{"query_id": "277", "query_text": "Commelina yellow mottle virus (ComYMV) has three typical badnavirus ORFs, capable of encoding proteins 23, 15, and 216 kD.", "negative": "Rapamycin delays aging in fruit flies.", "negatives": ["Rapamycin delays aging in fruit flies.", "Pioglitazone use is significantly associated with an increased risk of prostate cancer.", "H4 G94P proteins induce degradation of free histones via Rad53-dependent mechanisms.", "The one-child policy has created a hospitable environment for female infants.", "Rising temperatures caused by global warming increases risk of dengue fever transmission.", "Intake of folic acid (FA) and vitamin B6 (VB6) reduces levels of homocysteine.", "Egr3 regulates the homeostasis of B and T cells.", "Including pharmacists in rounding teams reduces the incidence of adverse drug events (ADEs).", "Active Ly49Q induces neutrophil polarization.", "miR-142-5P is a known regulator of raised body temperature."], "hard_negatives": ["Commelina yellow mottle virus (ComYMV) has three typical badnavirus ORFs, capable of encoding proteins 23, 15, and 216 kD.", "Commelina yellow mottle virus' (ComYMV) genome consists of 2140 baise pairs.", "Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 encourage West Nile virus replication in cortical neurons.", "Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 inhibit West Nile virus replication in cortical neurons.", "The PPR MDA5 has twenty N-terminal CARD domains.", "Bacteriophagaes MS2 and Q\u03b2 are members of the Leviviridae.", "Helminths interfere with immune system control of coinfections by microbial pathogens 16.", "Eilat virus (EILV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in nonhuman primates.", "Dscam1 acts as a hypervariable pattern-recognition receptor for the immune system.", "The predominant localization of Linc00173 is in mononuclear macrophage nuclei."], "hard_negative": "Commelina yellow mottle virus (ComYMV) has three typical badnavirus ORFs, capable of encoding proteins 23, 15, and 216 kD."}
{"query_id": "278", "query_text": "Commelina yellow mottle virus' (ComYMV) genome consists of 2140 baise pairs.", "negative": "RUNX is not expressed in skin tissue.", "negatives": ["RUNX is not expressed in skin tissue.", "Aged patients are more susceptible to ischaemia/reperfusion injury.", "Ethanol stress reduces the expression of SRL in bacteria.", "Taking 400mg of \u03b1-tocopheryl acetate does not prevent prostate cancer.", "A high microerythrocyte count protects against severe anemia in homozygous alpha (+)- thalassemia trait subjects.", "Mice without IFN-\u03b3 or its receptor are highly susceptible to EAM induced with \u03b1-MyHC/CFA.", "Tuberculosis-induced granulomas express different immune system protein signatures than the surrounding tissue.", "Cell autonomous sex determination in somatic cells occurs in Galliformes.", "The proportion of people with visual difficulty is two times higher in low-income countries than in high-income countries.", "Chemical injury represses transglutaminase 2 activity."], "hard_negatives": ["Commelina yellow mottle virus' (ComYMV) genome consists of 2140 baise pairs.", "Commelina yellow mottle virus (ComYMV) has three typical badnavirus ORFs, capable of encoding proteins 23, 15, and 216 kD.", "The PPR MDA5 has twenty N-terminal CARD domains.", "The predominant localization of Linc00173 is in mononuclear macrophage nuclei.", "Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 encourage West Nile virus replication in cortical neurons.", "Active H. pylori urease has a polymeric structure consisting of five distinct subunits.", "Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 inhibit West Nile virus replication in cortical neurons.", "Bacteriophagaes MS2 and Q\u03b2 are members of the Leviviridae.", "ScPif1p has higher binding ability to G-rich ssDNA than to non-G-rich ssDNA.", "The PRR MDA5 has a C-terminal domain."], "hard_negative": "Commelina yellow mottle virus' (ComYMV) genome consists of 2140 baise pairs."}
{"query_id": "280", "query_text": "Comparative transcriptome analysis identified new platelet proteins with structural features suggesting a role in platelet function.", "negative": "Stiff substrates encourage mesodermal differentiation by degrading beta-catenin in an integrin-dependent manner.", "negatives": ["Stiff substrates encourage mesodermal differentiation by degrading beta-catenin in an integrin-dependent manner.", "DUSP4 decreases apoptosis.", "Citrullinated proteins externalized in neutrophil extracellular traps act indirectly to perpetuate the inflammatory cycle via induction of autoantibodies.", "Cancer-associated fibroblasts (CAFs) interact with cancer cells to mediate formation and activation of CAFs.", "Algerian physicians constitue the largest component of sub-Saharan Africa-trained physicians in the United States.", "The PPR MDA5 has twenty N-terminal CARD domains.", "Mutations in RIM1 raise levels of IME1 RNA.", "Chlamydia trachomatis is most prevalent in the UK among individuals in their 50s and 60s.", "Pre-mRNAs associated with spliceosomal components are more stable than unassociated splicing substrates.", "Foxk2 regulates autophagy genes in muscle cells and fibroblast cells."], "hard_negatives": ["Comparative transcriptome analysis identified new platelet proteins with structural features suggesting a role in platelet function.", "Active caspase-11 participate in regulating phagosome-lysosome fusion.", "Binding of p53 to enhancer regions (p53BERs) regulates the activity of p53 transcription and cell cycle arrest through the production of p53-dependent eRNAs.", "Many cytokines that are produced by cancer cells also contribute to carcinogenesis.", "MEK inhibitors are effective treatments in RAS-driven mouse models of cancer.", "Lack of FGF21 in mice leads to atherosclerotic plaque formation.", "Many transmembrane receptors transmit signals by long-range conformational changes in the association of alpha-helices across the plasma membrane.", "Intramembrane cleavage by signal peptide peptidase aids in the degradation of proteins with a complex membrane orientation.", "Lack of FGF21 in mice slows the rate of atherosclerotic plaque formation.", "r-protein chaperones are found in complexes with their r-protein binding partners."], "hard_negative": "Comparative transcriptome analysis identified new platelet proteins with structural features suggesting a role in platelet function."}
{"query_id": "281", "query_text": "Concentrations of SNV and CNV in stem-cell regulatory elements and binding sites of transcription factors in iPSC-lines are distinct from their founding cells.", "negative": "90% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.", "negatives": ["90% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.", "Blocking the interaction between TDP-43 and respiratory complex I proteins ND3 and ND6 prevents TDP-43-induced neuronal loss.", "Glycan adaptation is rarely observed in the B-cell repertoire.", "ATF4 is a general endoplasmic reticulum stress marker.", "Helminths interfere with immune system control of coinfections by microbial pathogens 16.", "Mitochondria play a trivial role in calcium homeostasis.", "Gastric infection with Helicobacter pylori increases risk of gastric cancer in humans.", "miRNAs regulate a unique suite of mRNAs to maintain homeostasis in cells.", "Retinoic acid receptor-related orphan receptor gamma (ROR\u03b3) is a therapeutic target for castration-resistant prostate cancer (CRPC)", "Lipopolysaccharides have an inflammation independent effect on kidney barrier function."], "hard_negatives": ["Concentrations of SNV and CNV in stem-cell regulatory elements and binding sites of transcription factors in iPSC-lines are distinct from their founding cells.", "Cis-acting lncRNAs control the expression of genes that are positioned in the vicinity of their transcription sites.", "Distant CREs are important for transcriptional regulation.", "Binding of p53 to enhancer regions (p53BERs) regulates the activity of p53 transcription and cell cycle arrest through the production of p53-dependent eRNAs.", "Long - range chromatin interactions regulate transcription.", "Pre-mRNAs associated with spliceosomal components are more stable than unassociated splicing substrates.", "Pre-mRNAs associated with spliceosomal components are less stable than unassociated splicing substrates.", "Active caspase-11 participate in regulating phagosome-lysosome fusion.", "Overexpressing Cnp1 N-tail variants exacerbates the temperature-sensitive growth defect of scm3-139.", "The DEXI promoter region is bound by multiple transcription factors in a murine haematopoietic progenitor cell line."], "hard_negative": "Concentrations of SNV and CNV in stem-cell regulatory elements and binding sites of transcription factors in iPSC-lines are distinct from their founding cells."}
{"query_id": "283", "query_text": "Consumption of whole fruits increases the risk of type 2 diabetes.", "negative": "Normal granulomas form in the absence of TNF in Zebrafish.", "negatives": ["Normal granulomas form in the absence of TNF in Zebrafish.", "Obesity raises life quality.", "Tirasemtiv targets cardiac muscle.", "PKG-la does not have a large impact on expression of pain hypersensitivity in PGK-la knockout mice.", "1-1% of colorectal cancer patients are diagnosed with regional or distant metastases.", "Pyridostatin reduces proliferation of homologous recombination - defective cells.", "Patients in stable partnerships have a slower progression from HIV to AIDS.", "Cell autonomous sex determination in somatic cells occurs in Galliformes.", "ATF4 is a general endoplasmic reticulum stress marker.", "Mice lacking Sirt1 in Sf1-expressing neurons have increased susceptibility to diet-induced obesity and insulin resistance."], "hard_negatives": ["Consumption of whole fruits increases the risk of type 2 diabetes.", "Moderate consumption of candy and chocolate reduces the risk of cardiovascular disease (CVD).", "Taxation of sugar-sweetened beverages reduced the incidence rate of type II diabetes in India.", "It is not proven that moderate consumption of candy and chocolate reduces the risk of cardiovascular disease (CVD) specifically.", "Autophagy deficiency in the liver increases vulnerability to insulin resistance.", "Medications to treat obesity have unwanted side effects.", "Obesity decreases life quality.", "Medications to treat obesity do not have side effects.", "Suboptimal nutrition is a leading cause of premature death", "The risk of cancer rises with level of alcohol consumption."], "hard_negative": "Consumption of whole fruits increases the risk of type 2 diabetes."}
{"query_id": "285", "query_text": "Continued HHV-8 transmission among MSM in San Francisco may be explained by urogenital contact.", "negative": "Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection increases dissemination of Salmonella Typhimurium from the gut.", "negatives": ["Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection increases dissemination of Salmonella Typhimurium from the gut.", "Satellite cell dysfunction is a key factor in sarcopenia development.", "In rhesus macaques, daily subcutaneous injections of tenofovir protects against rectally transmitted simian-human immunodeficiency virus.", "Antimicrobial agents are more effective due to the pressure of antimicrobial usage.", "Rhythmic expression of Cry1 translates directly into a circadian regulation of cAMP signaling in hepatic glucose metabolism.", "Individuals with low serum vitamin D concentrations have decreased risk of multiple sclerosis.", "The PDPN gene deactivates the C-type lectin receptor (CLEC-2).", "Tonic signaling from the scFv is amplified by MyD88/CD40.", "32% of liver transplantation programs required patients to discontinue methadone treatment in 2001.", "Physical activity level is associated with the difference in maximal oxygen consumption between black and white youth."], "hard_negatives": ["Continued HHV-8 transmission among MSM in San Francisco may be explained by urogenital contact.", "The HSV-2 infection is typically asymptomatic.", "Chlamydia trachomatis is most prevalent in the UK among sexually-experienced individuals aged 16 to 24.", "Bacterial meningitis can be diagnosed on the basis of positive cerebrospinal fluid (CSF) cultures.", "Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection increases dissemination of Salmonella Typhimurium from the gut.", "Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection decreases dissemination of Salmonella Typhimurium from the gut.", "Urbanization is an important risk factor related to the transmission of dengue fever.", "Toll-like receptor (TLR) signaling is involved in the pathogenesis of human MDS.", "In rhesus macaques, daily subcutaneous injections of emtricitabine are ineffective at protecting against rectally transmitted simian-human immunodeficiency virus.", "Pediatric SCD patients with vaso-occlusive crisis show increased morphine use after breathing 80 ppm iNO for 4 hours."], "hard_negative": "Continued HHV-8 transmission among MSM in San Francisco may be explained by urogenital contact."}
{"query_id": "286", "query_text": "Converting apoE4 to apoE3 by gene editing prevents the pathology associated with apoE4 in human iPSCderived neurons.", "negative": "Mitochondria play a major role in apoptosis.", "negatives": ["Mitochondria play a major role in apoptosis.", "Sympathetic nerve activity is reduced throughout normal pregnancy.", "T cell receptor /CD3 microdomains are required to induce the immunologic synapse.", "\u03b21/Ketel is able to bind microtubules.", "Omnivores produce less trimethylamine N-oxide from dietary I-carnitine than vegans.", "The one-child policy has created a hospitable environment for female infants.", "Splenomegaly is observed in knockin mouse lacking the SHP-2 MAPK pathway.", "Antidepressants increase the severity of migraines.", "The G34R/V mutation does not create a hypomethylated phenotype at the H3K36 histone.", "APOE4 expression in iPSC-derived neurons results in decreased tau phosphorylation."], "hard_negatives": ["Converting apoE4 to apoE3 by gene editing prevents the pathology associated with apoE4 in human iPSCderived neurons.", "Converting apoE4 to apoE3 by gene editing worsens the pathology associated with apoE4 in human iPSCderived neurons.", "APOE4 expression in iPSC-derived neurons results in decreased tau phosphorylation.", "MeCP2 influences the synaptic maturation of neurons.", "p16INK4A degradation is  linked to an abnormal wound response caused by the microinvasive step of advanced Oral Potentially Malignant Lesions (OPMLs).", "FoxO3a activation in neuronal death is inhibited by reactive oxygen species (ROS).", "PKG-la plays an essential role in expression of spinal long term potentiation in PGK-la knockout mice.", "PKG-la does not have a large impact on expression of spinal long term potentiation in PGK-la knockout mice.", "ER-localized phosphatase Sac1 processes PI4P through coordination with OSBP and the endosome-localized protein sorting nexin 2.", "Reduced phosphorylation of PP2A increases HDAC4 dephosphorylation by enhancing PP2A-HDAC4 interaction."], "hard_negative": "Converting apoE4 to apoE3 by gene editing prevents the pathology associated with apoE4 in human iPSCderived neurons."}
{"query_id": "287", "query_text": "Converting apoE4 to apoE3 by gene editing worsens the pathology associated with apoE4 in human iPSCderived neurons.", "negative": "L3MBTL2 binds to H2AK119Ub marked chromatin to form a PRC1 complex.", "negatives": ["L3MBTL2 binds to H2AK119Ub marked chromatin to form a PRC1 complex.", "Ribosomopathies have a high degree of cell and tissue specific pathology.", "There is no association between HNF4A mutations and diabetes risks.", "Most termination events in Okazaki fragments are dictated by initiation patterns.", "Cytosolic proteins bind to iron-responsive elements on mRNAs coding for TFRC1.", "The proliferative capacity of neural progenitors differs across species.", "Obesity raises life quality.", "Alirocumab treatment reduces apo(a) fractional clearance rate.", "Expression of MSX2 is induced 3 hours after the addition of BMP4, which is earlier than T and CDX2.", "TNFAIP3 is a glioblastoma tumor enhancer."], "hard_negatives": ["Converting apoE4 to apoE3 by gene editing worsens the pathology associated with apoE4 in human iPSCderived neurons.", "Converting apoE4 to apoE3 by gene editing prevents the pathology associated with apoE4 in human iPSCderived neurons.", "APOE4 expression in iPSC-derived neurons results in decreased tau phosphorylation.", "MeCP2 influences the synaptic maturation of neurons.", "p16INK4A degradation is  linked to an abnormal wound response caused by the microinvasive step of advanced Oral Potentially Malignant Lesions (OPMLs).", "PKG-la does not have a large impact on expression of spinal long term potentiation in PGK-la knockout mice.", "PKG-la plays an essential role in expression of spinal long term potentiation in PGK-la knockout mice.", "FoxO3a activation in neuronal death is inhibited by reactive oxygen species (ROS).", "Activation of PPM1D enhances p53 function.", "Reduced phosphorylation of PP2A suppresses HDAC4 dephosphorylation."], "hard_negative": "Converting apoE4 to apoE3 by gene editing worsens the pathology associated with apoE4 in human iPSCderived neurons."}
{"query_id": "290", "query_text": "Cost effectiveness evaluations based on cRCT data accurately reflect prices for patients in actual clinical practice.", "negative": "Physical injury represses transgultaminase activity.", "negatives": ["Physical injury represses transgultaminase activity.", "Ca2+ cycling controls whole-body energy homeostasis in beige fat.", "Omnivores produce less trimethylamine N-oxide from dietary I-carnitine than vegans.", "Glioblastoma multiforme (GBM) is characterized by extensive invasion, rapid growth, necrosis, and angiogenesis.", "Oxidative DNA damage inhibits STING signalling.", "Fibroblast growth factor 21 protects against atherosclerosis by modulating adiponectin and SREBP2 levels.", "The cytokine receptor which regulates chemotaxis and formation of lymph nodes is involved in production of myeloperoxidase in the left atrium.", "Rapid phosphotransfer rates are correlated with histidine kinase regulator specificity.", "The effect of Lipopolysaccharides on kidney barrier function is dependent on inflammation levels.", "Antimicrobial agents are less effective due to the pressure of antimicrobial usage."], "hard_negatives": ["Cost effectiveness evaluations based on cRCT data accurately reflect prices for patients in actual clinical practice.", "Cost effectiveness evaluations based on cRCT data lack external validity.", "Measuring routine outcomes is more beneficial to clinical practice than assessing treatment adherence.", "Assessing treatment adherence is more beneficial to clinical practice than measuring routine outcomes.", "Risk-adjusted mortality rates are similar in teaching and non-teaching hospitals.", "Including pharmacists in rounding teams reduces the incidence of adverse drug events (ADEs).", "Including pharmacists in rounding teams does not alter the incidence of adverse drug events (ADEs).", "Weighed food records (WFR) result in poor completion since they're costly to run and impose high participant burden.", "Weighed food records (WFR) result in high completion since they're cheap to run and impose low participant burden.", "Therapeutics receiving accelerated approval encounter a lower frequency of post-marketing safety events"], "hard_negative": "Cost effectiveness evaluations based on cRCT data accurately reflect prices for patients in actual clinical practice."}
{"query_id": "292", "query_text": "Cost effectiveness evaluations based on cRCT data lack external validity.", "negative": "Mutations in G-Beta protein GNB1 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.", "negatives": ["Mutations in G-Beta protein GNB1 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.", "Aged patients are less susceptible to ischaemia/reperfusion injury.", "Activated Cdk5 phosphorylates the ATM protein in response to DNA damage.", "British female students are bullied more than British male students.", "Nonhuman primates are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.", "RANK-RANKL pathway signalling has no known association with development of Aire-expressing medullary thymic epithelial cells.", "Mice are incapable of producing neutralizing antibodies in reponse to the Chikungunya virus (CHIKV) produced in mosquitos.", "Transcription factor EB induces transcription of pro-inflammatory cytokines in macrophages infected with Staphylococcus aureus.", "Pre-mRNAs associated with spliceosomal components are less stable than unassociated splicing substrates.", "In transgenic mice harboring green florescent protein under the control of the Sox2 promoter, more than 50 percent of the cells with green florescent colocalize with cell proliferation markers."], "hard_negatives": ["Cost effectiveness evaluations based on cRCT data lack external validity.", "Cost effectiveness evaluations based on cRCT data accurately reflect prices for patients in actual clinical practice.", "Weighed food records (WFR) result in poor completion since they're costly to run and impose high participant burden.", "Measuring routine outcomes is more beneficial to clinical practice than assessing treatment adherence.", "Weighed food records (WFR) result in high completion since they're cheap to run and impose low participant burden.", "Assessing treatment adherence is more beneficial to clinical practice than measuring routine outcomes.", "Including pharmacists in rounding teams does not alter the incidence of adverse drug events (ADEs).", "Including pharmacists in rounding teams reduces the incidence of adverse drug events (ADEs).", "Integrated care is ineffective at tackling multiple comorbidities.", "Therapeutics receiving accelerated approval encounter a lower frequency of post-marketing safety events"], "hard_negative": "Cost effectiveness evaluations based on cRCT data lack external validity."}
{"query_id": "293", "query_text": "Crossover hot spots are found within gene promoters in Saccharomyces cerevisiae.", "negative": "H.pylori-mediated gastric cancer occurs due to the accumulation of mutations in host epithelial cells.", "negatives": ["H.pylori-mediated gastric cancer occurs due to the accumulation of mutations in host epithelial cells.", "The proliferative capacity of progenitors is regulated cell-autonomously.", "Progerin induces premature aging in stem cells.", "Expression of MSX2 is induced 3 hours after the addition of BMP4, which is earlier than T and CDX2.", "Lamins are found within the inner layer of the mitochondrial membrane of all cells.", "Occipital activation levels are associated with auditory spatial performance in parietal regions of the brain.", "Insulin decreases risk of severe kidney failure.", "Ca2+ cycling controls whole-body energy homeostasis in beige fat.", "RTEL1 interacts with TRF2 through a C4C4 motif", "siRNA knockdown of A20 slows tumor progression in an in vivo murine xenograft model."], "hard_negatives": ["Crossover hot spots are found within gene promoters in Saccharomyces cerevisiae.", "In domesticated populations of Saccharomyces cerevisiae, segmental aneuploidy occurs infrequently.", "In domesticated populations of Saccharomyces cerevisiae, segmental aneuploidy is very common.", "The Snf1 complex regulates carbon and energy metabolism in baker's yeast (Saccharomyces cerevisiae).", "A strong bias in the phage genome locations where the spacers were derived has been observed in many CRISPR subtypes that confer the immunity to phage.", "Long - range chromatin interactions regulate transcription.", "Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 inhibit West Nile virus replication in cortical neurons.", "Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 encourage West Nile virus replication in cortical neurons.", "Cis-acting lncRNAs control the expression of genes that are positioned in the vicinity of their transcription sites.", "The latent infection of myeloid cells with human cytomegalovirus induces a number of changes in gene expression."], "hard_negative": "Crossover hot spots are found within gene promoters in Saccharomyces cerevisiae."}
{"query_id": "296", "query_text": "Cyclin A2 destruction is necessary to switch from unstable to stable kt-mt attachments in mitosis.", "negative": "Aged patients are more susceptible to ischaemia/reperfusion injury.", "negatives": ["Aged patients are more susceptible to ischaemia/reperfusion injury.", "Certain immunomodulator-human dialyzable leukocyte extract (hDLE) peptides are recognized by toll-like receptors (TLRs) on macrophages and dendritic cells.", "Asymptomatic visual impairment screening in elderly populations leads to improved vision.", "Occipital activation levels are associated with auditory spatial performance in parietal regions of the brain.", "Pyridostatin deregulates G2/M progression.", "Venules have less significant tunica adventitia than arterioles.", "Ribosomopathies have a high degree of cell and tissue specific pathology.", "Flexible molecules experience less steric hindrance in the tumor microenviroment than rigid molecules.", "The deamination of cytidine to uridine on the minus strand of viral DNA can inactivate the viral genome by inducing G-to-A mutations.", "The amount of publicly available DNA data doubles every 10 months."], "hard_negatives": ["Cyclin A2 destruction is necessary to switch from unstable to stable kt-mt attachments in mitosis.", "Mitochondria play a trivial role in calcium homeostasis.", "Mitochondria play a major role in apoptosis.", "Clathrin stabilizes the spindle fiber apparatus during mitosis.", "Mitochondria play a major role in energy production.", "Alteration of origin firing causes changes in termination zones of Okazaki fragments.", "Cytochrome c is transferred from cytosol to the mitochondrial intermembrane space during apoptosis.", "Cellular clocks are not predictive of mitosis timing in NIH 3T3 cells.", "MT binding domain drives amyloid structure formation.", "siRNA knockdown of A20 slows tumor progression in an in vivo murine xenograft model."], "hard_negative": "Cyclin A2 destruction is necessary to switch from unstable to stable kt-mt attachments in mitosis."}
{"query_id": "299", "query_text": "Cytochrome c is transferred from cytosol to the mitochondrial intermembrane space during apoptosis.", "negative": "Human embryonic stem cells give rise to cell types from all three embryonic germ layers.", "negatives": ["Human embryonic stem cells give rise to cell types from all three embryonic germ layers.", "TNFAIP3 is a glioblastoma tumor enhancer.", "CCL19 is a ligand for CCR7.", "Repressing IL-18 has negative effects on atherosclerotic lesion composition and progression.", "B cells go though plasmablast differentiation and antibody production by continuous expression of EBI2.", "Overexpressing Cnp1 N-tail variants rescues the temperature-sensitive growth defect of scm3-139.", "Mice that lack Interferon-\u03b3 or its receptor are highly susceptible to experimental autoimmune myocarditis.", "The density of cytokine receptor bearing cells affects the distance over which cytokines act.", "A deficiency of vitamin B12 decreases blood levels of homocysteine.", "Taxation of sugar-sweetened beverages reduced the incidence rate of type II diabetes in India."], "hard_negatives": ["Cytochrome c is transferred from cytosol to the mitochondrial intermembrane space during apoptosis.", "Mitochondria play a major role in apoptosis.", "Immune complex triggered cell death leads to sequestration of oxidized mitochondrial DNA.", "BCL-2 activation antagonizes the apoptotic effects of c-Myc.", "The deamination of cytidine to uridine on the minus strand of viral DNA can inactivate the viral genome by inducing G-to-A mutations.", "Oxidative phosphorylation is one of the primary glycometabolic pathways in cells.", "BCL-2 promotes the apoptotic effects of c-Myc.", "Activated Cdk5 regulates DNA damage-induced neuronal death.", "Mitochondria play a major role in energy production.", "Reduced phosphorylation of PP2A increases HDAC4 dephosphorylation by enhancing PP2A-HDAC4 interaction."], "hard_negative": "Cytochrome c is transferred from cytosol to the mitochondrial intermembrane space during apoptosis."}
{"query_id": "301", "query_text": "Cytosolic proteins bind to iron-responsive elements on mRNAs coding for TFRC1.", "negative": "British male students are bullied more than British female students.", "negatives": ["British male students are bullied more than British female students.", "Type 1 Diabetes is associated with subtle perturbations in T reg development.", "British male students are bullied more than British female students.", "Sequence conservation in gene regulatory regions between species is a high-accuracy predictor of conserved functionality.", "Inhibiting HDAC6 increases survival of mice with ARID1A mutated tumors.", "Bone Marrow (BM) transplantation is used to treat acute myeloid leukemia (AML)", "Human embryonic stem cells give rise to cell types from the outer embryonic germ layer, but not the other two layers.", "PRC1-bound plasmids sediment at a slower rate in unbound plasmids than in sucrose gradients.", "Rapamycin delays aging in fruit flies.", "The H2A-H2B eviction defect is compensated for by other histone chaperone(s)."], "hard_negatives": ["Cytosolic proteins bind to iron-responsive elements on mRNAs coding for TFRC1.", "In S. cerevisiae, the absence of RNA surveillance pathways causes sensitivity to high iron conditions.", "In S. cerevisiae, the absence of RNA surveillance pathways reduces sensitivity to high iron conditions.", "Egr2 regulates the homeostasis of B and T cells.", "Mitochondria play a trivial role in calcium homeostasis.", "Egr3 regulates the homeostasis of B and T cells.", "A deficiency of folate increases blood levels of homocysteine.", "APOE4 expression in iPSC-derived neurons results in decreased tau phosphorylation.", "Osteocytes have an essential role in G-CSF induced HSPC mobilization.", "Transcription factor EB induces transcription of pro-inflammatory cytokines in macrophages infected with Staphylococcus aureus."], "hard_negative": "Cytosolic proteins bind to iron-responsive elements on mRNAs coding for TFRC1."}
{"query_id": "304", "query_text": "DMS3 protein enables Pol V transcription in vivo.", "negative": "Nonsteroidal antinflammatory drugs are ineffective as cancer treatments.", "negatives": ["Nonsteroidal antinflammatory drugs are ineffective as cancer treatments.", "Adult tissue-resident macrophages are seeded before birth.", "Pyridostatin reduces proliferation of homologous recombination - defective cells.", "M. stadtmanae does not induce ASC speck formation in BlaER1 monocytes.", "Genes involved in pre-mRNA splicing have a significant impact on genome stability.", "PRC1-bound plasmids sediment at a slower rate in unbound plasmids than in sucrose gradients.", "Immune complex triggered cell death leads to extracellular release of nuclear DNA.", "BRCA 1 mutation carriers' risk of breast and ovarian cancer depends on where the mutation is located.", "Bariatric surgery reduces postmenopausal breast cancer.", "Foxk2 regulates autophagy genes in muscle cells and fibroblast cells."], "hard_negatives": ["DMS3 protein enables Pol V transcription in vivo.", "DRD1 proteins enable Pol V transcription in vivo.", "LSD1-positive promoters are associated with RNA polymerase II", "JMJD6 catalyzes the hydroxylation of C-terminal lysine and supresses transcriptional activity.", "The PRDM1 gene, when combined with the PRDM14 gene, plays an important role during primordial germ cell specification.", "Foxp3 enables the expression of transcriptional regulators implicated in memory T cell development.", "ER-localized phosphatase Sac1 processes PI4P through coordination with OSBP and the endosome-localized protein sorting nexin 2.", "Binding of p53 to enhancer regions (p53BERs) regulates the activity of p53 transcription and cell cycle arrest through the production of p53-dependent eRNAs.", "TNFAIP3 is a glioblastoma tumor suppressor.", "PKG-la plays an essential role in expression of spinal long term potentiation in PGK-la knockout mice."], "hard_negative": "DMS3 protein enables Pol V transcription in vivo."}
{"query_id": "305", "query_text": "DRD1 proteins enable Pol V transcription in vivo.", "negative": "Energy balance requires hypothalamic glutamate neurotransmission.", "negatives": ["Energy balance requires hypothalamic glutamate neurotransmission.", "Walking in traffic areas in London did not improve lung function in elderly adults.", "The M2-phenotype in brown adipose tissue macrophages increases brown adipose tissue thermogenic activity.", "Activated Cdk5 regulates DNA damage-induced neuronal death.", "Beta-band coherence is diminished for visible stimuli over invisible stimuli.", "r-protein chaperones are found in complexes with their r-protein binding partners.", "FACT and other histone chaperone(s) compensate for Histone 2A (H2A)-histone 2B (H2B) dimer eviction during the histone exchange process.", "Ten percent (10%) of kidney cancers in the UK are attributable to excess weight.", "Self-advocacy training is effective at decreasing homelessness.", "Roughly 55% of women with chronic pelvic pain have no underlying pathology."], "hard_negatives": ["DRD1 proteins enable Pol V transcription in vivo.", "DMS3 protein enables Pol V transcription in vivo.", "LSD1-positive promoters are associated with RNA polymerase II", "The PRDM1 gene, when combined with the PRDM14 gene, plays an important role during primordial germ cell specification.", "Binding of p53 to enhancer regions (p53BERs) regulates the activity of p53 transcription and cell cycle arrest through the production of p53-dependent eRNAs.", "The repeat-variable diresidue (RVD) in the loop of Transcription-Activator Like (TAL) effectors specifies the nucleotides-amino acid contact at the target promoter element.", "The PRDM1 gene is a key determinant of primordial germ cells.", "Active caspase-11 participate in regulating phagosome-lysosome fusion.", "Distant CREs are important for transcriptional regulation.", "JMJD6 catalyzes the hydroxylation of C-terminal lysine and supresses transcriptional activity."], "hard_negative": "DRD1 proteins enable Pol V transcription in vivo."}
{"query_id": "306", "query_text": "DUSP4 decreases apoptosis.", "negative": "Commelina yellow mottle virus' (ComYMV) genome consists of 2140 baise pairs.", "negatives": ["Commelina yellow mottle virus' (ComYMV) genome consists of 2140 baise pairs.", "Mice lacking Sirt1 in Sf1-expressing neurons are immune to diet-induced obesity and insulin resistance.", "The PRDM1 gene is a key determinant of primordial germ cells.", "RUNX1 is downregulated or mutated in TLX1 T-ALL.", "Incidence of 10/66 dementia is lower than the incidence of DSM-IV dementia.", "TNFAIP3 is a glioblastoma tumor suppressor.", "There is no increased risk of hypospadias with clomiphene.", "Patients with microcytosis and higher erythrocyte count are more vulnerable to severe malarial anaemia when infected with Plasmodium falciparum.", "Adult tissue-resident macrophages stem from the embryonal yolk sac and fetal liver.", "Ultrasound guidance significantly reduces the number of needle insertion attempts necessary for a given procedure."], "hard_negatives": ["DUSP4 increases apoptosis.", "DUSP4 decreases apoptosis.", "DUSP4 downregulation deactivates the Ras-ERK pathway", "Reduced phosphorylation of PP2A suppresses HDAC4 dephosphorylation.", "Reduced phosphorylation of PP2A increases HDAC4 dephosphorylation by enhancing PP2A-HDAC4 interaction.", "Activation of PPM1D enhances p53 function.", "PD-1 triggering on monocytes enhances IL-10 production by monocytes.", "Deltex has no known interactions with eIF3f.", "Reduced levels of lipolysis leads to higher P38 phosphorylation in adipose tissue.", "Increased lipolysis leads to higher P38 phosphorylation in adipose tissue."], "hard_negative": "DUSP4 increases apoptosis."}
{"query_id": "308", "query_text": "DUSP4 downregulation deactivates the Ras-ERK pathway", "negative": "Immune responses in immune cells are geographically segregated.", "negatives": ["Immune responses in immune cells are geographically segregated.", "Insulin decreases risk of severe kidney failure.", "Having a main partner improves HIV outcomes.", "MEK inhibitors are effective treatments in RAS-driven mouse models of cancer.", "M. stadtmanae does not induce ASC speck formation in BlaER1 monocytes.", "Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission.", "LRBA prevents CTLA - 4 recycling.", "In young and middle-aged adults, current or remote uses of ADHD medications increase the risk of serious cardiovascular events.", "MT binding domain drives amyloid structure formation.", "Retinoic acid receptor-related orphan receptor gamma (ROR\u03b3) is a therapeutic target for castration-resistant prostate cancer (CRPC)"], "hard_negatives": ["DUSP4 downregulation deactivates the Ras-ERK pathway", "DUSP4 increases apoptosis.", "DUSP4 decreases apoptosis.", "Reduced phosphorylation of PP2A suppresses HDAC4 dephosphorylation.", "Reduced phosphorylation of PP2A increases HDAC4 dephosphorylation by enhancing PP2A-HDAC4 interaction.", "MEK inhibitors are effective treatments in RAS-driven mouse models of cancer.", "Activation of PPM1D enhances p53 function.", "Reduced levels of lipolysis leads to higher P38 phosphorylation in adipose tissue.", "Increased lipolysis leads to higher P38 phosphorylation in adipose tissue.", "PD-1 triggering on monocytes enhances IL-10 production by monocytes."], "hard_negative": "DUSP4 downregulation deactivates the Ras-ERK pathway"}
{"query_id": "309", "query_text": "DUSP4 increases apoptosis.", "negative": "An M2-like phenotype in brown adipose tissue macrophages is quickly induced by cold exposure.", "negatives": ["An M2-like phenotype in brown adipose tissue macrophages is quickly induced by cold exposure.", "Upon viral challenge, influenza-specific memory CD4+ T cells greatly enhance the early production of inflammatory chemokines in the lung.", "Ethanol stress increases the expression of IBP in bacteria.", "Occipital activation levels are associated with auditory spatial performance in parietal regions of the brain.", "In rhesus macaques, daily subcutaneous injections of tenofovir protects against rectally transmitted simian-human immunodeficiency virus.", "TMEM27 is a marker for beta cells.", "Moderate consumption of candy and chocolate reduces the risk of cardiovascular disease (CVD).", "Omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegetarians.", "The tissue surrounding the granuloma in an immune cell induces an anti-inflammatory immune response.", "Increased mobility of retrotransposons is assosciated with mutation and higher tumorigenesis rates."], "hard_negatives": ["DUSP4 increases apoptosis.", "DUSP4 decreases apoptosis.", "DUSP4 downregulation deactivates the Ras-ERK pathway", "Reduced phosphorylation of PP2A suppresses HDAC4 dephosphorylation.", "Reduced phosphorylation of PP2A increases HDAC4 dephosphorylation by enhancing PP2A-HDAC4 interaction.", "Activation of PPM1D enhances p53 function.", "PD-1 triggering on monocytes enhances IL-10 production by monocytes.", "Deltex has no known interactions with eIF3f.", "Increased lipolysis leads to higher P38 phosphorylation in adipose tissue.", "Reduced levels of lipolysis leads to higher P38 phosphorylation in adipose tissue."], "hard_negative": "DUSP4 increases apoptosis."}
{"query_id": "310", "query_text": "De novo assembly of sequence data has fewer specific contigs than unassembled sequence data.", "negative": "RUNX1 is downregulated or mutated in TLX1 T-ALL.", "negatives": ["RUNX1 is downregulated or mutated in TLX1 T-ALL.", "CDK6 shows improved binding to loss-of-function variants of p18 INK4C.", "Interleukin-18 plays an important role in the pathogenesis of atherosclerosis.", "Origin gross domestic product(GDP) is positively related to dengue virus (DENV-1) diffusion in air traffic shipments.", "Insulin decreases risk of severe kidney failure.", "The combination of physical examinations with C-reactive protein values do not improve the accuracy of radiographic verified pneumonia predictions.", "Having a main partner worsens HIV outcomes.", "The World Health Organization's (WHO) data collection process is biased downward by unequal selection of larger outbreaks.", "Many cytokines that are produced by cancer cells also contribute to carcinogenesis.", "ATM and Rad3 related protein are critical for sensing DNA damage."], "hard_negatives": ["De novo assembly of sequence data has fewer specific contigs than unassembled sequence data.", "De novo assembly of sequence data has shorter contigs than unassembled sequence data.", "Flexible molecules experience less steric hindrance in the tumor microenviroment than rigid molecules.", "Understanding epigenetic regulation of replication is essential for the reational design of episomally replicating vectors.", "0-dimensional biomaterials lack inductive properties.", "Genes involved in pre-mRNA splicing have a significant impact on genome stability.", "Mouse models can be generated using \"artificial spermatids.\"", "Sequence conservation in gene regulatory regions between species is a high-accuracy predictor of conserved functionality.", "The amount of publicly available DNA data doubles every 10 months.", "Pre-mRNAs associated with spliceosomal components are less stable than unassociated splicing substrates."], "hard_negative": "De novo assembly of sequence data has fewer specific contigs than unassembled sequence data."}
{"query_id": "313", "query_text": "De novo assembly of sequence data has shorter contigs than unassembled sequence data.", "negative": "Transcription rates in S. cerevisiae range between 0.7 and 2 kb/min.", "negatives": ["Transcription rates in S. cerevisiae range between 0.7 and 2 kb/min.", "Bacteriophagaes MS2 and Q\u03b2 are members of the Leviviridae.", "Tirasemtiv targets fast-twitch muscle.", "Bone Marrow (BM) transplantation is used to treat acute myeloid leukemia (AML)", "Pharmacist attendance at ward rounds reduces adverse events in wards.", "Activated Cdk5 regulates DNA damage-induced neuronal death.", "Lack of FGF21 in mice increases life expectancy.", "53% of perinatal mortality is due to low birth weight.", "Acute ablation of Snail in the embryonic cortex affects the proliferation and number of embryonic cortical precursors.", "Monoclonal antibody targeting of N-cadherin encourages metastasis."], "hard_negatives": ["De novo assembly of sequence data has shorter contigs than unassembled sequence data.", "De novo assembly of sequence data has fewer specific contigs than unassembled sequence data.", "Flexible molecules experience less steric hindrance in the tumor microenviroment than rigid molecules.", "Understanding epigenetic regulation of replication is essential for the reational design of episomally replicating vectors.", "Genes involved in pre-mRNA splicing have a significant impact on genome stability.", "0-dimensional biomaterials lack inductive properties.", "Mouse models can be generated using \"artificial spermatids.\"", "Transcription rates in S. cerevisiae range between 0.7 and 2 kb/min.", "The amount of publicly available DNA data doubles every 10 months.", "Sequence conservation in gene regulatory regions between species is a high-accuracy predictor of conserved functionality."], "hard_negative": "De novo assembly of sequence data has shorter contigs than unassembled sequence data."}
{"query_id": "315", "query_text": "Decrease of p62 in prostate tumor stroma results in defective autophagy.", "negative": "A strong bias in the phage genome locations where the spacers were derived has been observed in many CRISPR subtypes that confer the immunity to phage.", "negatives": ["A strong bias in the phage genome locations where the spacers were derived has been observed in many CRISPR subtypes that confer the immunity to phage.", "Smc5/6 engagment halts the activation of SUMO E3 ligase Mms21 by ATP-dependent remolding.", "JMJD6 slows the hydroxylation of C-terminal lysine", "Monoclonal antibody targeting of N-cadherin inhibits growth.", "Omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegetarians.", "Major antigen-induced signals from the T cell receptor and secondary signals from costimulatory receptors are required for T cell activation.", "General exercise therapy is more effective than scapular stabilizer exercises in reducing pain and improving function of the shoulder.", "PCSK9 inhibitors decrease plasma Lp(a) levels.", "The effect of Lipopolysaccharides on kidney barrier function is dependent on inflammation levels.", "Roughly 55% of women with chronic pelvic pain have no underlying pathology."], "hard_negatives": ["Decrease of p62 in prostate tumor stroma results in defective autophagy.", "Increase of p62 in prostate tumor stroma results in defective autophagy.", "Taking 400mg of \u03b1-tocopheryl acetate does not prevent prostate cancer.", "Pioglitazone use is not associated with an increased risk of prostate cancer.", "Taking 400mg of \u03b1-tocopheryl acetate in combination with vitamin C reduces the risk of prostate cancer.", "Activation of PPM1D enhances p53 function.", "Reduced levels of lipolysis leads to higher P38 phosphorylation in adipose tissue.", "Increased lipolysis leads to higher P38 phosphorylation in adipose tissue.", "Upregulation of PD1 causes the downmodulation of Satb1.", "Upregulation of PD1 causes the upregulation of Satb1."], "hard_negative": "Decrease of p62 in prostate tumor stroma results in defective autophagy."}
{"query_id": "316", "query_text": "Decreased conversion of PGE 2 to PPARy ligand 15-ket-PGE 2 causes accumulation of PGE.", "negative": "Obesity decreases life quality.", "negatives": ["Obesity decreases life quality.", "The DESMOND program demonstrates no significant impact on weight loss.", "Helminths interfere with immune system control of coinfections by microbial pathogens 16.", "The PRDM1 gene, when combined with the PRDM14 gene, plays an important role during primordial germ cell specification.", "The combination of physical examinations with C-reactive protein values do not improve the accuracy of radiographic verified pneumonia predictions.", "Elevated cell-free mitochondrial DNA levels are associated with mortality.", "Exercise reduces cancer mortality rates among Chinese citizens.", "Amitriptyline is an effective treatment for chronic tension-type headaches.", "Differentiation of progenitor cells to myeloid cells is skewed when insulin signaling is suppressed.", "Reduction of Rpl38 alters the composition of the Hox gene mRNAs translation in mice without lowering overall protein synthesis."], "hard_negatives": ["Decreased conversion of PGE 2 to PPARy ligand 15-ket-PGE 2 causes accumulation of PGE.", "Increased conversion of PGE 2 to PPARy ligand 15-ket-PGE 2 causes accumulation of PGE.", "High levels of CRP lead to a higher risk of exacerbations in chronic obstructive pulmonary disease (COPD).", "PKG-la does not have a large impact on expression of pain hypersensitivity in PGK-la knockout mice.", "Reduced phosphorylation of PP2A increases HDAC4 dephosphorylation by enhancing PP2A-HDAC4 interaction.", "PGE 2 suppresss intestinal tumor growth by altering the expression of tumor suppressing and DNA repair genes.", "Increased LDL receptors plays a role in the reduction of plasma Lp(a).", "Reduced phosphorylation of PP2A suppresses HDAC4 dephosphorylation.", "PCSK9 inhibitors decrease plasma Lp(a) levels.", "There is no increased risk of hypospadias with clomiphene."], "hard_negative": "Decreased conversion of PGE 2 to PPARy ligand 15-ket-PGE 2 causes accumulation of PGE."}
{"query_id": "317", "query_text": "Decreased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm.", "negative": "Upregulation of PD1 causes the upregulation of Satb1.", "negatives": ["Upregulation of PD1 causes the upregulation of Satb1.", "Rhythmic expression of Cry1 translates directly into a circadian regulation of cAMP signaling in hepatic glucose metabolism.", "Microglia are an innate immune cell type of the peripheral nervous system.", "In young and middle-aged adults, current or remote uses of ADHD medications increase the risk of serious cardiovascular events.", "Cholesterol loading induces KLF4 expression in VSMCs, resulting in the expression of pro-inflammatory cytokines.", "Participants who quit smoking reduce lung cancer risk by approximately 50%.", "Traditional reviews are biased in their interpretations.", "N348I mutations cause resistance to nevirapine.", "MUC1-C activates the NF-\u03baB p65 signaling pathway by interacting with I\u03baB kinase \u00df.", "The tissue surrounding the granuloma in an immune cell induces an anti-inflammatory immune response."], "hard_negatives": ["Decreased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm.", "Increased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm.", "Ambulatory blood pressure monitoring is inaccurate at diagnosing hypertension.", "Sudden death can occur in patients with orthostatic hypertension without cardiac conduction abnormalities.", "CRP is positively correlated with postoperative mortality following Coronary Artery Bypass Graft (CABG) surgery.", "High levels of CRP lead to a higher risk of exacerbations in chronic obstructive pulmonary disease (COPD).", "Sudden death can occur in patients with complex ventricular arrhythmias.", "Diabetic patients with acute coronary syndrome experience decreased short-term and long-term risk for bleeding events.", "AMP-activated protein kinase (AMPK) activation reduces inflammation-related fibrosis in the lungs.", "Noninvasive positive pressure ventilation is not predictive of acute respiratory failure after solid organ transplantation."], "hard_negative": "Decreased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm."}
{"query_id": "323", "query_text": "Deleting Raptor increases G-CSF levels.", "negative": "L3MBTL2 binds to H2AK119Ub marked chromatin to form a PRC1 complex.", "negatives": ["L3MBTL2 binds to H2AK119Ub marked chromatin to form a PRC1 complex.", "NR5A2 is important in reverse cholesterol transport in humans.", "The PRR MDA5 has a C-terminal domain.", "R2D2 stops miRNA production by increasing the selectivity of Dcr2 for long dsRNA.", "Physical activity does not improve cognitive function in individuals with Alzheimers.", "Patients with microcytosis and higher erythrocyte count are more vulnerable to severe malarial anaemia when infected with Plasmodium falciparum.", "Foxk2 regulates autophagy genes in muscle cells and fibroblast cells.", "The combination of physical examinations with C-reactive protein values do not improve the accuracy of radiographic verified pneumonia predictions.", "Increase of p62 in prostate tumor stroma results in defective autophagy.", "PTEN is a regulator for the transcriptional activity of SRF"], "hard_negatives": ["Deleting Raptor increases G-CSF levels.", "G-CSF increases the expansion and infiltration of MDSCs into tumors.", "Osteocytes have an essential role in G-CSF induced HSPC mobilization.", "cSMAC formation represses weak ligand signalling.", "Patients with panic anxiety show decreased CSF levels of hypocretin.", "The deamination of cytidine to uridine on the minus strand of viral DNA can inactivate the viral genome by inducing G-to-A mutations.", "MafA ubiquitination decreases the recruitment of coavtivator P/CAF by MafA.", "ScPif1p has reduced binding ability to G-rich ssDNA compared to non-G-rich ssDNA.", "Glycan adaptation involves insertion-deletion events.", "MafA ubiquitination increases the recruitment of coavtivator P/CAF by MafA."], "hard_negative": "Deleting Raptor increases G-CSF levels."}
{"query_id": "325", "query_text": "Deletion of ATM and Rad3 related protein is not predictive of acute tissue loss.", "negative": "Monoclonal antibody targeting of N-cadherin encourages castration resistance.", "negatives": ["Monoclonal antibody targeting of N-cadherin encourages castration resistance.", "Upregulation of dynein in Drosophila neurons increases the number of microtubule plus-ends growing toward the cell body of each neuron.", "PKG-la plays an essential role in expression of spinal long term potentiation in PGK-la knockout mice.", "PKG-la plays an essential role in expression of spinal long term potentiation in PGK-la knockout mice.", "Human embryonic stem cells give rise to cell types from the outer embryonic germ layer, but not the other two layers.", "Vitamin D deficiency effects birth weight.", "The generation of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells.", "Myelin sheaths play a role in action potential propagation.", "LRBA promotes CTLA - 4 recycling.", "70% of burn patients are admitted for hospitalization and further treatment after appearing at hospital emergency wards or outpatient clinics."], "hard_negatives": ["Deletion of ATM and Rad3 related protein is not predictive of acute tissue loss.", "Deletion of ATM and Rad3 related protein leads to acute tissue loss.", "ATM and Rad3 related protein have no role in sensing DNA damage.", "ATM and Rad3 related protein are critical for sensing DNA damage.", "Activated Cdk5 phosphorylates the ATM protein in response to DNA damage.", "Gpr124 suppresses BBB breakdown in mouse models of ischemic stroke.", "MEK inhibitors are effective treatments in RAS-driven mouse models of cancer.", "Sudden death can occur in patients with orthostatic hypertension without cardiac conduction abnormalities.", "Gpr124 increases BBB breakdown in mouse models of ischemic stroke.", "Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes epithelial damage."], "hard_negative": "Deletion of ATM and Rad3 related protein is not predictive of acute tissue loss."}
{"query_id": "326", "query_text": "Deletion of ATM and Rad3 related protein leads to acute tissue loss.", "negative": "Stiff substrates inhibit mesodermal differentiation by degrading beta-catenin in an integrin-dependent manner.", "negatives": ["Stiff substrates inhibit mesodermal differentiation by degrading beta-catenin in an integrin-dependent manner.", "HbA1c consistently overestimates glycemic control in black individuals with Sickle cell trait (SCT).", "Improvements in OER catalysts show stable activity over several hundred hours.", "Bariatric surgery reduces colorectal cancer.", "Environmental factors can influence the development of breast cancer.", "Whole brain radiotherapy increases the occurrence of new brain metastases.", "Forkhead 0 (fox0) transcription factors are involved in cellular differentiation.", "Bone Marrow (BM) transplantation is used to treat acute myeloid leukemia (AML)", "Patients with microcytosis and higher erythrocyte count were more resistant to severe malarial anaemia when infected with Plasmodium falciparum.", "Mouse models can be generated using \"artificial spermatids.\""], "hard_negatives": ["Deletion of ATM and Rad3 related protein leads to acute tissue loss.", "Deletion of ATM and Rad3 related protein is not predictive of acute tissue loss.", "ATM and Rad3 related protein have no role in sensing DNA damage.", "ATM and Rad3 related protein are critical for sensing DNA damage.", "Activated Cdk5 phosphorylates the ATM protein in response to DNA damage.", "Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes epithelial damage.", "Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes fibrosis.", "Gpr124 suppresses BBB breakdown in mouse models of ischemic stroke.", "MEK inhibitors are effective treatments in RAS-driven mouse models of cancer.", "Major vault protein (MVP) leads to more aggressive tumors by regulating the sorting of tumor suppressive miR-193a into extracellular vesicles (EVs)."], "hard_negative": "Deletion of ATM and Rad3 related protein leads to acute tissue loss."}
{"query_id": "330", "query_text": "Deltex has no known interactions with eIF3f.", "negative": "Commelina yellow mottle virus (ComYMV) has three typical badnavirus ORFs, capable of encoding proteins 23, 15, and 216 kD.", "negatives": ["Commelina yellow mottle virus (ComYMV) has three typical badnavirus ORFs, capable of encoding proteins 23, 15, and 216 kD.", "Adult tissue-resident macrophages are seeded before birth.", "LDL cholesterol has a causal role in the development of cardiovascular disease.", "Side effects associated with antidepressants increases risk of stroke.", "Tuberculosis-induced granulomas express different immune system protein signatures than the surrounding tissue.", "Surfactin producing cells and exopolymer producing cells cooperate to generate \"Van Gogh\" bundles that have sliding abilities on specialized media.", "VgrG (Tssl) protein punctures membranes by forming a spike at the tip of the tube apparatus.", "Persistor cells are one reason for incomplete responses to Tyrosine kinase inhibitor (TKI) therapy in cancer patients.", "Activation of the Rac1 homolog CED-10 kills viable cells in SRGP-1 mutant Caenorhabditis elegans.", "Removal of H3K9me3 by ectopic expression of other H3K9 demethylases decreases reprogramming efficiency in SCNT experiments."], "hard_negatives": ["Deltex has no known interactions with eIF3f.", "Deltex interacts with eIF3. There is no known interaction between Deltex and elF3", "ScPif1p has reduced binding ability to G-rich ssDNA compared to non-G-rich ssDNA.", "ScPif1p has higher binding ability to G-rich ssDNA than to non-G-rich ssDNA.", "TNFAIP3 is a glioblastoma tumor suppressor.", "ATF4 is a general endoplasmic reticulum stress marker.", "The PRR MDA5 has a C-terminal domain.", "The PPR MDA5 has twenty N-terminal CARD domains.", "TNFAIP3 is a glioblastoma tumor enhancer.", "MafA phosphorylation enhances its ubiquitination."], "hard_negative": "Deltex has no known interactions with eIF3f."}
{"query_id": "331", "query_text": "Deltex interacts with eIF3. There is no known interaction between Deltex and elF3", "negative": "A diminished ovarian reserve is a very strong indicator of infertility, even in an a priori non-infertile population.", "negatives": ["A diminished ovarian reserve is a very strong indicator of infertility, even in an a priori non-infertile population.", "Allogeneic mechanical circulatory support is not as effective as autologous mechanical circulatory support for treating acute myocardial infarction.", "In S. cerevisiae, the absence of RNA surveillance pathways causes sensitivity to high iron conditions.", "Mice defective for deoxyribonucleic acid (DNA) polymerase I (polI) fail to reveal increased sensitivity to ionizing radiation (IR).", "Lipopolysaccharides have an inflammation independent effect on kidney barrier function.", "A 100g dose of chloroquine chemoprophylactic regimen results in retinal toxicity after 1 year of weekly intake.", "Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection decreases dissemination of Salmonella Typhimurium from the gut.", "Microcin J25 encourages nucleoside triphosphate (NTP) binding.", "5'-nucleotidase metabolizes 6MP.", "Allogeneic mechanical circulatory support is not as effective as autologous mechanical circulatory support for treating acute myocardial infarction."], "hard_negatives": ["Deltex interacts with eIF3. There is no known interaction between Deltex and elF3", "Deltex has no known interactions with eIF3f.", "RTEL1 interacts with TRF2 through a C4C4 motif", "The minor G allele of FOXO3 up-regulates IL-10.", "EGR2 is important to myelination of the peripheral nervous system.", "Egr3 regulates the homeostasis of B and T cells.", "DUSP4 downregulation deactivates the Ras-ERK pathway", "Recognition of start codons depends on the translation initiation factor IF3.", "JMJD6 slows the hydroxylation of C-terminal lysine", "IFI16 impedes STING phosphorylation and translocation, resulting in reduced activation of STING."], "hard_negative": "Deltex interacts with eIF3. There is no known interaction between Deltex and elF3"}
{"query_id": "332", "query_text": "Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection decreases dissemination of Salmonella Typhimurium from the gut.", "negative": "Surgical treatment is not superior to non-surgical in treating adults with displaced fractures of the proximal humerus.", "negatives": ["Surgical treatment is not superior to non-surgical in treating adults with displaced fractures of the proximal humerus.", "Ly49Q directs the organization of neutrophil polarization by regulating membrane raft functions.", "Including pharmacists in rounding teams does not alter the incidence of adverse drug events (ADEs).", "BCL-2 activation antagonizes the apoptotic effects of c-Myc.", "Citrullinated proteins externalized in neutrophil extracellular traps act indirectly to disrupt the inflammatory cycle.", "IgA plasma cells that are specific for transglutaminase 2 are scarce in the duodenal mucosa of celiac disease patients when the disease is active.", "Marmosets have a brain region homologous to Broca's area.", "Mouse models can be generated using \"artificial spermatids.\"", "Gpr124 increases BBB breakdown in mouse models of ischemic stroke.", "Klf4 is not required for proper myeloid cell differentiation."], "hard_negatives": ["Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection decreases dissemination of Salmonella Typhimurium from the gut.", "Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection increases dissemination of Salmonella Typhimurium from the gut.", "Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 inhibit West Nile virus replication in cortical neurons.", "Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 encourage West Nile virus replication in cortical neurons.", "The latent infection of myeloid cells with human cytomegalovirus induces a number of changes in gene expression.", "A T helper 2 cell (Th2) environment impedes disease development in patients with systemic lupus erythematosus (SLE).", "Nonhuman primates are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.", "Tuberculosis-induced granulomas express different immune system protein signatures than the surrounding tissue.", "The HSV-2 infection is typically asymptomatic.", "Eilat virus (EILV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in nonhuman primates."], "hard_negative": "Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection decreases dissemination of Salmonella Typhimurium from the gut."}
{"query_id": "333", "query_text": "Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection increases dissemination of Salmonella Typhimurium from the gut.", "negative": "Converting apoE4 to apoE3 by gene editing worsens the pathology associated with apoE4 in human iPSCderived neurons.", "negatives": ["Converting apoE4 to apoE3 by gene editing worsens the pathology associated with apoE4 in human iPSCderived neurons.", "Klf4 is important for proper myeloid cell differentiation.", "In S. cerevisiae, the absence of RNA surveillance pathways causes sensitivity to high iron conditions.", "Vitamin D deficiency effects birth weight.", "Localization of PIN1 in the roots of Arabidopsis requires VPS9a", "The proportion of people with visual difficulty is two times higher in low-income countries than in high-income countries.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have shorter lifetime exposure to estrogen due to a decreased reproductive period.", "Antiretroviral therapy increases rates of tuberculosis across a broad range of CD4 strata.", "Increased mobility of retrotransposons does not lead to mutation and higher tumorigenesis rates.", "Systemic immunosuppressive (IS) therapy increases the chance of cancer mortality in patients with inflammatory eye disease (IED)"], "hard_negatives": ["Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection increases dissemination of Salmonella Typhimurium from the gut.", "Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection decreases dissemination of Salmonella Typhimurium from the gut.", "Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 inhibit West Nile virus replication in cortical neurons.", "The latent infection of myeloid cells with human cytomegalovirus induces a number of changes in gene expression.", "Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 encourage West Nile virus replication in cortical neurons.", "A T helper 2 cell (Th2) environment impedes disease development in patients with systemic lupus erythematosus (SLE).", "Nonhuman primates are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.", "The HSV-2 infection is typically asymptomatic.", "Tuberculosis-induced granulomas express different immune system protein signatures than the surrounding tissue.", "Eilat virus (EILV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in nonhuman primates."], "hard_negative": "Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection increases dissemination of Salmonella Typhimurium from the gut."}
{"query_id": "334", "query_text": "Depletion of nitric oxide is responsible for vasospasm.", "negative": "\u03b2-sheet opening occurs during pleurotolysin pore formation.", "negatives": ["\u03b2-sheet opening occurs during pleurotolysin pore formation.", "Klf4 is important for proper myeloid cell differentiation.", "During the primary early antibody response activated B cells migrate toward the inner-and outer follicular areas where oxysterol accumulation is generated by stromal cells.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have longer lifetime exposure to estrogen due to an increased reproductive period.", "MeCP2 influences the synaptic maturation of neurons.", "Incidence of 10/66 dementia is higher than the incidence of DSM-IV dementia.", "The ability of activator E2Fs in preventing cell death is limited to terminally differentiated cells.", "Increase of p62 in prostate tumor stroma results in defective autophagy.", "Alteration of origin firing causes changes in termination zones of Okazaki fragments.", "Whole brain radiotherapy increases the occurrence of new brain metastases."], "hard_negatives": ["Depletion of nitric oxide is responsible for vasospasm.", "Reduced levels of lipolysis leads to higher P38 phosphorylation in adipose tissue.", "Increased lipolysis leads to higher P38 phosphorylation in adipose tissue.", "The effect of Lipopolysaccharides on kidney barrier function is dependent on inflammation levels.", "Differentiation of progenitor cells to myeloid cells is skewed when insulin signaling is suppressed.", "The cytokine receptor which regulates chemotaxis and formation of lymph nodes is involved in production of myeloperoxidase in the left atrium.", "Higher plasma levels of I-carnitine, when associated with trimethylamine N-oxide, are negatively correlated with cardiovascular events in humans.", "Higher plasma levels of I-carnitine, when associated with trimethylamine N-oxide, are positively correlated with cardiovascular events in humans.", "Sudden death can occur in patients with orthostatic hypertension without cardiac conduction abnormalities.", "Differentiation of progenitor cells to myeloid cells is skewed upon activation of insulin signaling."], "hard_negative": "Depletion of nitric oxide is responsible for vasospasm."}
{"query_id": "335", "query_text": "Deregulation of HAND2 is a crucial step in endometrial carcinogenesis in mice.", "negative": "The latent infection of myeloid cells with human cytomegalovirus induces a number of changes in gene expression.", "negatives": ["The latent infection of myeloid cells with human cytomegalovirus induces a number of changes in gene expression.", "Physical injury represses transgultaminase activity.", "Most termination events in Okazaki fragments are dictated by initiation patterns.", "Activator-inhibitor pairs are provided ventrally by Xrl-sizzled.", "Perigenital skin is not the primary site of HIV acquisition.", "Pre-mRNAs associated with spliceosomal components are more stable than unassociated splicing substrates.", "Adult tissue-resident macrophages are seeded before birth.", "ART has no effect on the infectiveness of HIV-positive people.", "p75 NTR - associated cell death executor (NADE) interacts with the p75 NTR death domain", "The appearance of brown-like or beige cells primarily occurs in visceral fat, not subcutaneous fat."], "hard_negatives": ["Deregulation of HAND2 is a crucial step in endometrial carcinogenesis in mice.", "HAND2 methylation is a key step in early endometrial carcinogenesis.", "NR5A2 does not play a role in development of endometrial tissues.", "Many cytokines that are produced by cancer cells also contribute to carcinogenesis.", "EGR2 is important to myelination of the peripheral nervous system.", "Decrease of p62 in prostate tumor stroma results in defective autophagy.", "PGE 2 suppresss intestinal tumor growth by altering the expression of tumor suppressing and DNA repair genes.", "Increase of p62 in prostate tumor stroma results in defective autophagy.", "In breast cancer, the loss of myoepithelial cells slows the transition of ductal carcinoma in situ to invasive carcinoma.", "Foxk2 regulates autophagy genes in muscle cells and fibroblast cells."], "hard_negative": "Deregulation of HAND2 is a crucial step in endometrial carcinogenesis in mice."}
{"query_id": "336", "query_text": "Destination container port throughput(CPT) is negatively related to dengue virus (DENV-1) diffusion in air traffic shipments.", "negative": "ScPif1p has reduced binding ability to G-rich ssDNA compared to non-G-rich ssDNA.", "negatives": ["ScPif1p has reduced binding ability to G-rich ssDNA compared to non-G-rich ssDNA.", "Cancers that initially benefit from epidermal growth factor receptor targeted therapies later become refractory through several mechanisms.", "A diminished ovarian reserve does not solely indicate infertility in an a priori non-infertile population.", "Incidence of sepsis has fallen substantially from 2009 to 2014.", "Destination container port throughput(CPT) is negatively related to dengue virus (DENV-1) diffusion in air traffic shipments.", "Guanine nucleotide exchange factors (GEFs) mediate RhoA activation in response to tensional forces on fibronectin-binding integrins.", "Microcin J25 encourages nucleoside triphosphate (NTP) binding.", "5'-nucleotidase metabolizes 6MP.", "Patients with common epithelial cancers  are more likely to have an emergency event as their first hospital admission if they live in resource-deprived areas.", "Monoclonal antibody targeting of N-cadherin inhibits castration resistance."], "hard_negatives": ["Destination container port throughput(CPT) is negatively related to dengue virus (DENV-1) diffusion in air traffic shipments.", "Destination container port throughput(CPT) is positively related to dengue virus (DENV-1) diffusion in air traffic shipments.", "Origin gross domestic product(GDP) is negatively related to dengue virus (DENV-1) diffusion in air traffic shipments.", "Origin gross domestic product(GDP) is positively related to dengue virus (DENV-1) diffusion in air traffic shipments.", "Urbanization is an important risk factor related to the transmission of dengue fever.", "Rising temperatures caused by global warming increases risk of dengue fever transmission.", "Rising temperatures caused by global warming lowers the risk of dengue fever transmission.", "Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 inhibit West Nile virus replication in cortical neurons.", "Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 encourage West Nile virus replication in cortical neurons.", "Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection increases dissemination of Salmonella Typhimurium from the gut."], "hard_negative": "Destination container port throughput(CPT) is negatively related to dengue virus (DENV-1) diffusion in air traffic shipments."}
{"query_id": "337", "query_text": "Destination container port throughput(CPT) is positively related to dengue virus (DENV-1) diffusion in air traffic shipments.", "negative": "The M2-phenotype in brown adipose tissue macrophages increases brown adipose tissue thermogenic activity.", "negatives": ["The M2-phenotype in brown adipose tissue macrophages increases brown adipose tissue thermogenic activity.", "Deltex interacts with eIF3. There is no known interaction between Deltex and elF3", "Guanine nucleotide exchange factors (GEFs) mediate RhoA activation in response to tensional forces on fibronectin-binding integrins.", "Taking 400mg of \u03b1-tocopheryl acetate does not prevent prostate cancer.", "Normal granulomas form in the absence of TNF in Zebrafish.", "Chlamydia trachomatis is most prevalent in the UK among individuals in their 50s and 60s.", "Mice without IFN-\u03b3 or its receptor are highly susceptible to EAM induced with \u03b1-MyHC/CFA.", "In transgenic mice harboring green florescent protein under the control of the Sox2 promoter, more than 50 percent of the cells with green florescent colocalize with cell proliferation markers.", "Expression of MSX2 is induced 3 hours after the addition of BMP4, which is earlier than T and CDX2.", "Ultrasound guidance significantly reduces the number of traumatic procedures when attempting needle insertion."], "hard_negatives": ["Destination container port throughput(CPT) is negatively related to dengue virus (DENV-1) diffusion in air traffic shipments.", "Destination container port throughput(CPT) is positively related to dengue virus (DENV-1) diffusion in air traffic shipments.", "Origin gross domestic product(GDP) is positively related to dengue virus (DENV-1) diffusion in air traffic shipments.", "Origin gross domestic product(GDP) is negatively related to dengue virus (DENV-1) diffusion in air traffic shipments.", "Urbanization is an important risk factor related to the transmission of dengue fever.", "Rising temperatures caused by global warming increases risk of dengue fever transmission.", "Rising temperatures caused by global warming lowers the risk of dengue fever transmission.", "Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 inhibit West Nile virus replication in cortical neurons.", "Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 encourage West Nile virus replication in cortical neurons.", "A country's Vaccine Alliance (GAVI) eligibility is not indictivate of accelerated adoption of the Hub vaccine."], "hard_negative": "Destination container port throughput(CPT) is negatively related to dengue virus (DENV-1) diffusion in air traffic shipments."}
{"query_id": "339", "query_text": "Dexamethasone increases risk of postoperative bleeding.", "negative": "1 in 5 million in UK have abnormal PrP positivity.", "negatives": ["1 in 5 million in UK have abnormal PrP positivity.", "Decrease of p62 in prostate tumor stroma results in defective autophagy.", "Cardiac tissue-resident macrophages directly contribute to electrical activity.", "Carriers of HNF4A mutations are at reduced risk for diabetes.", "Integrated care is ineffective at tackling multiple comorbidities.", "76-85% of people with severe mental disorder receive no treatment in low and middle income countries.", "p75 NTR - associated cell death executor (NADE) interacts with the p75 NTR death domain", "DRD1 proteins enable Pol V transcription in vivo.", "Low expression of miR7a does not repress target genes or exert a biological function in testis.", "Deltex has no known interactions with eIF3f."], "hard_negatives": ["Dexamethasone increases risk of postoperative bleeding.", "Side effects associated with antidepressants increases risk of stroke.", "Sildenafil worsens erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.", "Side effects associated with antidepressants do not represent a mortality risk to postmenopausal women.", "Side effects associated with antidepressants lower risk of myocardial infarction.", "Pioglitazone use is significantly associated with an increased risk of pancreatic cancer.", "Pioglitazone use is significantly associated with an increased risk of prostate cancer.", "Stroke patients with prior use of direct oral anticoagulants have a higher risk of in-hospital mortality than stroke patients with prior use of warfarin.", "Pioglitazone use is not associated with an increased risk of prostate cancer.", "The most prevalent adverse events to Semaglutide are cardiovascular."], "hard_negative": "Dexamethasone increases risk of postoperative bleeding."}
{"query_id": "340", "query_text": "Diabetes remission occurs less in people treated with conventional therapy than in people treated with laparoscopic adjustable gastric banding surgery.", "negative": "Rapamycin increases the concentration of triacylglycerols in fruit flies.", "negatives": ["Rapamycin increases the concentration of triacylglycerols in fruit flies.", "7-day-old adult Caenorhabditis elegans exhibit approximately 5% of the learning capacity seen in 1-day old adults.", "There is no known interaction between Pioneer factor OCT3/4 and major chromatin remodeling factors.", "76-85% of people with severe mental disorder receive no treatment in low and middle income countries.", "De novo assembly of sequence data has shorter contigs than unassembled sequence data.", "Medications to treat obesity are highly effective.", "Higher plasma levels of I-carnitine, when associated with trimethylamine N-oxide, are positively correlated with cardiovascular events in humans.", "aPKCz causes tumour suppression by affecting glutamine metabolism.", "Side effects associated with antidepressants increases risk of stroke.", "Acute ablation of Snail in the embryonic cortex affects the proliferation and number of embryonic cortical precursors."], "hard_negatives": ["Diabetes remission occurs less in people treated with conventional therapy than in people treated with laparoscopic adjustable gastric banding surgery.", "Diabetes remission occurs more in people treated with conventional therapy than in people treated with laparoscopic adjustable gastric banding surgery.", "In young and middle-aged adults, current or remote uses of ADHD medications increase the risk of serious cardiovascular events.", "Autophagy deficiency in the liver increases vulnerability to insulin resistance.", "Sudden death can occur in patients with orthostatic hypertension without cardiac conduction abnormalities.", "Diabetic patients with acute coronary syndrome experience decreased short-term and long-term risk for bleeding events.", "Medications to treat obesity do not have side effects.", "Insulin decreases risk of severe kidney failure.", "Nonhypertensive people who are 55 years old have a 90% chance of developing hypertension during their lifetime.", "Ambulatory blood pressure monitoring is inaccurate at diagnosing hypertension."], "hard_negative": "Diabetes remission occurs less in people treated with conventional therapy than in people treated with laparoscopic adjustable gastric banding surgery."}
{"query_id": "341", "query_text": "Diabetes remission occurs more in people treated with conventional therapy than in people treated with laparoscopic adjustable gastric banding surgery.", "negative": "Ethanol stress lowers the expression of PSP in bacteria.", "negatives": ["Ethanol stress lowers the expression of PSP in bacteria.", "Risedronate increases risk of vertebral and non-vertebral fractures.", "There is no increased risk of hypospadias with clomiphene.", "Primary pro-inflammatory cytokines suppress secondary pro- and anti-inflammatory mediators.", "Active Ly49Q prevents neutrophil polarization.", "Piezo1 channels are sensors for cell migration in epithelial cells.", "Environmental factors can influence the development of breast cancer.", "In domesticated populations of Saccharomyces cerevisiae, segmental aneuploidy is very common.", "Higher plasma levels of I-carnitine, when associated with trimethylamine N-oxide, are negatively correlated with cardiovascular events in humans.", "The amount of publicly available DNA data doubles every 10 months."], "hard_negatives": ["Diabetes remission occurs more in people treated with conventional therapy than in people treated with laparoscopic adjustable gastric banding surgery.", "Diabetes remission occurs less in people treated with conventional therapy than in people treated with laparoscopic adjustable gastric banding surgery.", "Autophagy deficiency in the liver increases vulnerability to insulin resistance.", "In young and middle-aged adults, current or remote uses of ADHD medications increase the risk of serious cardiovascular events.", "Sudden death can occur in patients with orthostatic hypertension without cardiac conduction abnormalities.", "Diabetic patients with acute coronary syndrome experience decreased short-term and long-term risk for bleeding events.", "Insulin decreases risk of severe kidney failure.", "Medications to treat obesity do not have side effects.", "Nonhypertensive people who are 55 years old have a 90% chance of developing hypertension during their lifetime.", "Ambulatory blood pressure monitoring is inaccurate at diagnosing hypertension."], "hard_negative": "Diabetes remission occurs more in people treated with conventional therapy than in people treated with laparoscopic adjustable gastric banding surgery."}
{"query_id": "342", "query_text": "Diabetic patients with acute coronary syndrome experience decreased short-term and long-term risk for bleeding events.", "negative": "Ethanol stress increases the expression of IBP in bacteria.", "negatives": ["Ethanol stress increases the expression of IBP in bacteria.", "During non-homologous end joining, the ligation step is not as tolerant of disrepairs and other distortions when joining 3' of strand breaks as compared to 5' strand breaks.", "Lack of FGF21 in mice leads to reduced lifespan.", "A diminished ovarian reserve is a very strong indicator of infertility, even in an a priori non-infertile population.", "Scapular stabilizer exercises are more effective than general exercise therapy in reducing pain and improving function of the shoulder.", "Primary cervical cancer screening with HPV detection has lower longitudinal sensitivity than conventional cytology to detect cervical intraepithelial neoplasia grade 2.", "A mutation in HNF4A leads to an increased risk of developing diabetes by the age of 14 years.", "Differentiation of progenitor cells to myeloid cells is skewed when insulin signaling is suppressed.", "JMJD6 slows the hydroxylation of C-terminal lysine", "Chemical injury represses transglutaminase 2 activity."], "hard_negatives": ["Diabetic patients with acute coronary syndrome experience decreased short-term and long-term risk for bleeding events.", "CRP is positively correlated with postoperative mortality following Coronary Artery Bypass Graft (CABG) surgery.", "Sudden death can occur in patients with orthostatic hypertension without cardiac conduction abnormalities.", "In young and middle-aged adults, current or remote uses of ADHD medications increase the risk of serious cardiovascular events.", "High levels of CRP lead to a higher risk of exacerbations in chronic obstructive pulmonary disease (COPD).", "Sudden death can occur in patients with complex ventricular arrhythmias.", "Risk of cardiovascular events can be cut by a third by using antihypertensive drug therapy among hemodialysis patients.", "Decreased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm.", "Side effects associated with antidepressants lower risk of myocardial infarction.", "Mice that lack Interferon-\u03b3 or its receptor are highly susceptible to experimental autoimmune myocarditis."], "hard_negative": "Diabetic patients with acute coronary syndrome experience decreased short-term and long-term risk for bleeding events."}
{"query_id": "345", "query_text": "Differentiated E2f-1, -2, -3 TKO cells in the intestine do not exhibit apoptosis.", "negative": "Intake of folic acid (FA) and vitamin B6 (VB6) reduces levels of homocysteine.", "negatives": ["Intake of folic acid (FA) and vitamin B6 (VB6) reduces levels of homocysteine.", "Mice defective for deoxyribonucleic acid (DNA) polymerase m (polm) reveal increased sensitivity to ionizing radiation (IR).", "The TRaF1/C5 rs10818488 allele polymorphism regulates the neighboring C5 gene.", "A strong bias in the phage genome locations where the spacers were derived has been observed in many CRISPR subtypes that confer the immunity to phage.", "90% of patients with melanoma and an objective response to PD-1 blockade will experience a progression in their melanoma.", "IgA plasma cells that are specific for transglutaminase 2 are scarce in the duodenal mucosa of celiac disease patients when the disease is active.", "Increased microtubule acetylation exacerbates LRRK2 Roc-COR domain mutation induced locomotor deficits.", "Increased purity of cytoplasmic membranes isolated from overexpressors is indicated by stronger spots for OmpF in 2D BN-PAGE gels.", "Sweet taste receptors on the tongue are deactivated by between 1 and 10 mM glucose.", "Mice defective for deoxyribonucleic acid (DNA) polymerase I (polI) fail to reveal increased sensitivity to ionizing radiation (IR)."], "hard_negatives": ["Differentiated E2f-1, -2, -3 TKO cells in the intestine do not exhibit apoptosis.", "The ability of activator E2Fs in preventing cell death is limited to terminally differentiated cells.", "Differentiation of progenitor cells to myeloid cells is skewed when insulin signaling is suppressed.", "TNFAIP3 is a glioblastoma tumor suppressor.", "Klf4 is not required for proper myeloid cell differentiation.", "Differentiation of progenitor cells to myeloid cells is skewed upon activation of insulin signaling.", "Klf4 is important for proper myeloid cell differentiation.", "Bone marrow cells don't contribute to adult macrophage compartments.", "Osteocytes have an essential role in G-CSF induced HSPC mobilization.", "TNFAIP3 is a tumor enhancer in glioblastoma."], "hard_negative": "Differentiated E2f-1, -2, -3 TKO cells in the intestine do not exhibit apoptosis."}
{"query_id": "346", "query_text": "Differentiation of progenitor cells to myeloid cells is skewed upon activation of insulin signaling.", "negative": "Natriuretic peptides increase susceptibility to diabetes.", "negatives": ["Natriuretic peptides increase susceptibility to diabetes.", "Prescribed exercise training improves quality of life.", "Phase information is useful for predicting donor-recipient matches in organ transplantation.", "Therapeutics receiving accelerated approval encounter a lower frequency of post-marketing safety events", "Human embryonic stem cells give rise to cell types from all three embryonic germ layers.", "Alirocumab treatment reduces apo(a) fractional clearance rate.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have longer lifetime exposure to estrogen due to an increased reproductive period.", "Cancer-associated fibroblasts (CAFs) have no known interaction with cancer cells in the formation and activation of CAFs.", "A single nucleotide variant the gene DGKK is strongly associated with increased risk of hypospadias.", "PRC1-bound plasmids sediment at a slower rate in unbound plasmids than in sucrose gradients."], "hard_negatives": ["Differentiation of progenitor cells to myeloid cells is skewed upon activation of insulin signaling.", "Differentiation of progenitor cells to myeloid cells is skewed when insulin signaling is suppressed.", "Cancer cells can stimulate the accumulation of intra-tumoural myeloid-derived suppressor cells by promoting granulocyte colony stimulating factor production.", "The proliferative capacity of progenitors is regulated cell-autonomously.", "Klf4 is important for proper myeloid cell differentiation.", "The myocardial cell lineage originally develops from cardiac progenitors of exclusively endodermal origin.", "Klf4 is not required for proper myeloid cell differentiation.", "Autophagy deficiency in the liver increases vulnerability to insulin resistance.", "Klf2 is important for proper myeloid cell function.", "Cancer-associated fibroblasts (CAFs) interact with cancer cells to mediate formation and activation of CAFs."], "hard_negative": "Differentiation of progenitor cells to myeloid cells is skewed upon activation of insulin signaling."}
{"query_id": "347", "query_text": "Differentiation of progenitor cells to myeloid cells is skewed when insulin signaling is suppressed.", "negative": "Systemic immunosuppressive (IS) therapy does not enhance the chance of cancer mortality in patients with inflammatory eye disease (IED)", "negatives": ["Systemic immunosuppressive (IS) therapy does not enhance the chance of cancer mortality in patients with inflammatory eye disease (IED)", "PrimPol generates short DNA replication intermediates on the leading strand during DNA replication.", "VgrG (Tssl) protein punctures membranes by forming a spike at the tip of the tube apparatus.", "Normal expression of RUNX1 causes tumorsupressing effects.", "Autologous transplantation of mesenchymal stem cells has better graft function than induction therapy with anti-interleukin-2 receptor antibodies.", "Commelina yellow mottle virus (ComYMV) has three typical badnavirus ORFs, capable of encoding proteins 23, 15, and 216 kD.", "Inhibiting focal adhesion formation enables cells to convert mechanical strain into eventual scarring.", "Angiotensin converting enzyme inhibitors are associated with decreased risk for functional renal insufficiency.", "Broadly HIV-1 Neutralizing Antibodies (bnAb) 10EB have no affinity for phospholipids.", "A T helper 2 cell (Th2) environment impedes disease development in patients with systemic lupus erythematosus (SLE)."], "hard_negatives": ["Differentiation of progenitor cells to myeloid cells is skewed when insulin signaling is suppressed.", "Differentiation of progenitor cells to myeloid cells is skewed upon activation of insulin signaling.", "Cancer cells can stimulate the accumulation of intra-tumoural myeloid-derived suppressor cells by promoting granulocyte colony stimulating factor production.", "Klf4 is important for proper myeloid cell differentiation.", "Klf4 is not required for proper myeloid cell differentiation.", "Autophagy deficiency in the liver increases vulnerability to insulin resistance.", "The proliferative capacity of progenitors is regulated cell-autonomously.", "The myocardial cell lineage originally develops from cardiac progenitors of exclusively endodermal origin.", "Klf2 is important for proper myeloid cell function.", "Cancer-associated fibroblasts (CAFs) interact with cancer cells to mediate formation and activation of CAFs."], "hard_negative": "Differentiation of progenitor cells to myeloid cells is skewed when insulin signaling is suppressed."}
{"query_id": "349", "query_text": "Diminished ovarian reserve is a reliable indicator of infertility in a non-infertile population.", "negative": "Patients with common epithelial cancers are less likely to have an emergency event as their first hospital admission if they live in resource-deprived areas.", "negatives": ["Patients with common epithelial cancers are less likely to have an emergency event as their first hospital admission if they live in resource-deprived areas.", "PrimPol generates short DNA replication intermediates on the leading strand during DNA replication.", "Piezo1 channels are sensors for cell migration in epithelial cells.", "In chronic viral infections or tumors, peptides that selectively inhibit PTPRS can be utilized to boost insufficient activity of pDCs.", "Post-transcriptional handling of mitochondrial transcripts occurs in mitochondrial RNA granules.", "Propriospinal interneurons that play a role in the plastic reorganization of spinal circuits are integral for recovery from spinal cord injury.", "IL-6 signaling plays a major role in atherosclerotic cardiovascular disease.", "The generation of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells.", "Risk-adjusted mortality rates are similar in teaching and non-teaching hospitals.", "Diminished ovarian reserve is a reliable indicator of infertility in a non-infertile population."], "hard_negatives": ["Diminished ovarian reserve is a reliable indicator of infertility in a non-infertile population.", "A diminished ovarian reserve is a very strong indicator of infertility, even in an a priori non-infertile population.", "A diminished ovarian reserve does not solely indicate infertility in an a priori non-infertile population.", "The mean suicide rate in women is lower after miscarriage than live birth.", "The mean suicide rate in women is higher after miscarriage than live birth.", "The number of unfertilized oocytes in mated hermaphrodites increases with age.", "The risk of breast cancer among parous women decreases with placental weight of pregnancies.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have shorter lifetime exposure to estrogen due to a decreased reproductive period.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have longer lifetime exposure to estrogen due to an increased reproductive period.", "53% of perinatal mortality is due to low birth weight."], "hard_negative": "Diminished ovarian reserve is a reliable indicator of infertility in a non-infertile population."}
{"query_id": "351", "query_text": "Distant CREs are important for transcriptional regulation.", "negative": "Misunderstandings between doctors and patients can lead to non-adherence.", "negatives": ["Misunderstandings between doctors and patients can lead to non-adherence.", "Vitamin D deficiency effects birth weight.", "Tumor development occurs in conjunction with suppression of pro-inflammatory cytokines.", "Increased flux of microbial products suppresses immune responses.", "Chlamydia trachomatis is most prevalent in the UK among individuals in their 50s and 60s.", "A mutation in HNF4A leads to an increased risk of developing diabetes by the age of 14 years.", "Cnn1 recruitment varies with cell cycle timing.", "Autophagy deficiency in the liver increases vulnerability to insulin resistance.", "Treatment with a protein named FN impairs regenerative abilities of aged muscles.", "Androgenetic haploid mouse embryonic stem cells (ESCs) can be derived and genetically manipulated in vitro."], "hard_negatives": ["Distant CREs are important for transcriptional regulation.", "Distant CREs are less conserved among species.", "Long - range chromatin interactions regulate transcription.", "Cis-acting lncRNAs control the expression of genes that are positioned in the vicinity of their transcription sites.", "Active caspase-11 participate in regulating phagosome-lysosome fusion.", "Forkhead 0 (fox0) transcription factors are involved in cellular differentiation.", "Sequence conservation in gene regulatory regions between species is a high-accuracy predictor of conserved functionality.", "Binding of p53 to enhancer regions (p53BERs) regulates the activity of p53 transcription and cell cycle arrest through the production of p53-dependent eRNAs.", "eRNAs influence is linked to senescence, aging, and carcinogenesis.", "Concentrations of SNV and CNV in stem-cell regulatory elements and binding sites of transcription factors in iPSC-lines are distinct from their founding cells."], "hard_negative": "Distant CREs are important for transcriptional regulation."}
{"query_id": "352", "query_text": "Distant CREs are less conserved among species.", "negative": "DUSP4 downregulation deactivates the Ras-ERK pathway", "negatives": ["DUSP4 downregulation deactivates the Ras-ERK pathway", "Sepsis related mortality has risen from 2009 to 2014.", "TRAP+ osteoclasts regulate mature osteoblast maintenance.", "Activator-inhibitor pairs are provided ventrally by Xrl-sizzled.", "Pro-inflammatory cytokines are up repressed during tumor development.", "AZT given with ribavirin increases anemia.", "Anthrax spores are very difficult to dispose once they are dispersed.", "The G34R/V mutation does not create a hypomethylated phenotype at the H3K36 histone.", "PRC1-bound plasmids sediment at a slower rate in unbound plasmids than in sucrose gradients.", "Emodin forms hydrogen bonds with residues involved in PGAM1 substrate binding."], "hard_negatives": ["Distant CREs are less conserved among species.", "Distant CREs are important for transcriptional regulation.", "Sequence conservation in gene regulatory regions between species is a high-accuracy predictor of conserved functionality.", "Sequence conservation in gene regulatory regions between species is a poor predictor of conserved functionality.", "Pseudoknots are not evolutionarily conserved in most eukaryotes.", "r-protein chaperones are found in complexes with their r-protein binding partners.", "Long - range chromatin interactions regulate transcription.", "mcm 5 s 2 U is required for proper decoding of NNR codons in eukaryotes.", "A strong bias in the phage genome locations where the spacers were derived has been observed in many CRISPR subtypes that confer the immunity to phage.", "Low nucleosome occupancy correlates with high methylation levels across species."], "hard_negative": "Distant CREs are less conserved among species."}
{"query_id": "355", "query_text": "Drosophila supracellular actomyosin structures are found at boundaries in wing imaginal discs.", "negative": "B3-Galectin decreases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR.", "negatives": ["B3-Galectin decreases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR.", "Deregulation of HAND2 is a crucial step in endometrial carcinogenesis in mice.", "Women with a lower birth weight are more likely to develop breast cancer later in life.", "Tuberculosis incidence occurs at higher rates in more sparsely populated areas in the UK.", "B3-Galectin increases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR.", "GATA3 regulates cell cycle progression in bone marrow hematopoietic stem cells.", "qSOFA scores are associated with length of stay in emergency department patients.", "Having a main partner improves HIV outcomes.", "Lipopolysaccharides have an inflammation independent effect on kidney barrier function.", "Active caspase-11 participate in regulating phagosome-lysosome fusion."], "hard_negatives": ["Drosophila supracellular actomyosin structures are found at boundaries in wing imaginal discs.", "The C-type lectin receptor (CLEC-2) rearranges the actin cytoskeleton in dendritic cells to promote efficient motility along stromal surfaces.", "Lamins are found within the inner layer of the nuclear membrane of all cells.", "Lamins are found within the inner layer of the mitochondrial membrane of all cells.", "Activator-inhibitor pairs are provided ventrally by Xrl-sizzled.", "Lamins are associated with nuclear membrane structure maintenance.", "Cis-acting lncRNAs control the expression of genes that are positioned in the vicinity of their transcription sites.", "Upregulation of dynein in Drosophila neurons increases the number of microtubule plus-ends growing toward the cell body of each neuron.", "Myelin sheaths are lipid-rich cellular structures.", "MICAL redox enzymes regulate actin dynamics in many cell types."], "hard_negative": "Drosophila supracellular actomyosin structures are found at boundaries in wing imaginal discs."}
{"query_id": "356", "query_text": "Dscam1 acts as a hypervariable pattern-recognition receptor for the immune system.", "negative": "BiP is a general endoplasmic reticulum stress marker.", "negatives": ["BiP is a general endoplasmic reticulum stress marker.", "p16INK4A degradation is  linked to an abnormal wound response caused by the microinvasive step of advanced Oral Potentially Malignant Lesions (OPMLs).", "Sepsis related mortality has risen from 2009 to 2014.", "Bone Marrow (BM) transplantation is used to treat acute myeloid leukemia (AML)", "The repeat-variable diresidue (RVD) in the loop of Transcription-Activator Like (TAL) effectors specifies the nucleotides-amino acid contact at the target promoter element.", "The peak incidence of fractures occurs during pubertal growth spurt in early adolescents.", "Hematopoietic Stem Cell purification reaches purity rates above 90%.", "Natriuretic peptides increase susceptibility to diabetes.", "Lamins are found within the inner layer of the nuclear membrane of all cells.", "In melanoma, anti-CTLA-4 treatment reinvigorates exhausted PD-1+Eomes+CD8 T cells."], "hard_negatives": ["Dscam1 acts as a hypervariable pattern-recognition receptor for the immune system.", "Microglia are an innate immune cell type of the central nervous system.", "The PPR MDA5 has twenty N-terminal CARD domains.", "The PRR MDA5 has a C-terminal domain.", "Toll-like receptor (TLR) signaling is involved in the pathogenesis of human MDS.", "Microglia are an innate immune cell type of the peripheral nervous system.", "TMEM27 is a marker for beta cells.", "The latent infection of myeloid cells with human cytomegalovirus induces a number of changes in gene expression.", "TNFAIP3 is a glioblastoma tumor suppressor.", "Commelina yellow mottle virus (ComYMV) has three typical badnavirus ORFs, capable of encoding proteins 23, 15, and 216 kD."], "hard_negative": "Dscam1 acts as a hypervariable pattern-recognition receptor for the immune system."}
{"query_id": "357", "query_text": "During non-homologous end joining, the ligation step is not as tolerant of disrepairs and other distortions when joining 3' of strand breaks as compared to 5' strand breaks.", "negative": "Monoclonal antibody targeting of N-cadherin encourages metastasis.", "negatives": ["Monoclonal antibody targeting of N-cadherin encourages metastasis.", "Splenomegaly is observed in knockin mouse lacking the SHP-2 MAPK pathway.", "Acute ablation of Snail in the embryonic cortex affects the proliferation and number of embryonic cortical precursors.", "Diabetes remission occurs less in people treated with conventional therapy than in people treated with laparoscopic adjustable gastric banding surgery.", "An M2-like phenotype in brown adipose tissue macrophages is quickly induced by cold exposure.", "Primary cervical cytology screening with HPV detection has higher longitudinal sensitivity to detect severe cervical intraepithelial neoplasia than conventional cytology.", "Charcoal shows no benefit for acute paraquat poisoning.", "Aggravated inflammation is dependent on NLRP3 inflammasome activation.", "Cholesterol loading induces KLF4 expression in VSMCs, resulting in the expression of pro-inflammatory cytokines.", "MafA ubiquitination increases the recruitment of coavtivator P/CAF by MafA."], "hard_negatives": ["During non-homologous end joining, the ligation step is not as tolerant of disrepairs and other distortions when joining 3' of strand breaks as compared to 5' strand breaks.", "During non-homologous end joining, the ligation step is not as tolerant of disrepairs and other distortions when joining 5' of strand breaks as compared to 3' strand breaks.", "mcm 5 s 2 U is required for proper decoding of NNR codons in eukaryotes.", "Recognition of start codons depends on the translation initiation factor IF3.", "The artifactual C-terminal helix swapping in the StART domain is observed in the Ups1-Mdm35 heterodimer of the StARkin superfamily.", "Pyridostatin prevents double-strand breaks accumulation.", "R2D2 stops miRNA production by increasing the selectivity of Dcr2 for long dsRNA.", "The H2A-H2B eviction defect is compensated for by other histone chaperone(s).", "Stacking is more stable when a purine is present in the +5 position (C1698).", "Overexpressing Cnp1 N-tail variants rescues the temperature-sensitive growth defect of scm3-139."], "hard_negative": "During non-homologous end joining, the ligation step is not as tolerant of disrepairs and other distortions when joining 3' of strand breaks as compared to 5' strand breaks."}
{"query_id": "358", "query_text": "During non-homologous end joining, the ligation step is not as tolerant of disrepairs and other distortions when joining 5' of strand breaks as compared to 3' strand breaks.", "negative": "Lamins are associated with nuclear membrane structure maintenance.", "negatives": ["Lamins are associated with nuclear membrane structure maintenance.", "The HSV-2 infection is typically asymptomatic.", "CD44v6 is not associated with constitutive and reprogrammed cancer stem cells driving cancer metastasis.", "Tuberculosis-induced granulomas express different immune system protein signatures than the surrounding tissue.", "HIV trans-activator protein (TAT) effectively transports large and small molecules across cellular membranes into larger populations of neurons.", "Reduction of Rpl38 alters the composition of the Hox gene mRNAs translation in mice without lowering overall protein synthesis.", "In a naive state, blocking Wingless-Int-1 secretion from mouse embryonic stem cells inhibits self-renewal of the mouse embryonic stem cells.", "Antimicrobial agents are more effective due to the pressure of antimicrobial usage.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have increased risk for Alzheimer's disease.", "Monoclonal antibody targeting of N-cadherin inhibits growth."], "hard_negatives": ["During non-homologous end joining, the ligation step is not as tolerant of disrepairs and other distortions when joining 5' of strand breaks as compared to 3' strand breaks.", "During non-homologous end joining, the ligation step is not as tolerant of disrepairs and other distortions when joining 3' of strand breaks as compared to 5' strand breaks.", "mcm 5 s 2 U is required for proper decoding of NNR codons in eukaryotes.", "The artifactual C-terminal helix swapping in the StART domain is observed in the Ups1-Mdm35 heterodimer of the StARkin superfamily.", "R2D2 stops miRNA production by increasing the selectivity of Dcr2 for long dsRNA.", "Pyridostatin prevents double-strand breaks accumulation.", "The H2A-H2B eviction defect is compensated for by other histone chaperone(s).", "Stacking is more stable when a purine is present in the +5 position (C1698).", "Overexpressing Cnp1 N-tail variants rescues the temperature-sensitive growth defect of scm3-139.", "Recognition of start codons depends on the translation initiation factor IF3."], "hard_negative": "During non-homologous end joining, the ligation step is not as tolerant of disrepairs and other distortions when joining 5' of strand breaks as compared to 3' strand breaks."}
{"query_id": "361", "query_text": "During the primary early antibody response activated B cells migrate toward the inner-and outer follicular areas where oxysterol accumulation is generated by stromal cells.", "negative": "Retinoic acid receptor-related orphan receptor gamma (ROR\u03b3) is a therapeutic target for castration-resistant prostate cancer (CRPC)", "negatives": ["Retinoic acid receptor-related orphan receptor gamma (ROR\u03b3) is a therapeutic target for castration-resistant prostate cancer (CRPC)", "Deregulation of HAND2 is a crucial step in endometrial carcinogenesis in mice.", "Upregulation of dynein in Drosophila neurons increases the number of microtubule plus-ends growing toward the cell body of each neuron.", "The innate immune response struggles to remove small numbers of parasites.", "Cellular clocks are not predictive of mitosis timing in NIH 3T3 cells.", "A deficiency of vitamin B6 decreases blood levels of homocysteine.", "Medications to treat obesity are highly effective.", "Progerin induces premature aging in stem cells.", "Sepsis related mortality has risen from 2009 to 2014.", "Activator-inhibitor pairs are provided ventrally by Xrl-sizzled."], "hard_negatives": ["During the primary early antibody response activated B cells migrate toward the inner-and outer follicular areas where oxysterol accumulation is generated by stromal cells.", "B cells go though plasmablast differentiation and antibody production by continuous expression of EBI2.", "Citrullinated proteins externalized in neutrophil extracellular traps act indirectly to perpetuate the inflammatory cycle via induction of autoantibodies.", "Varying expression levels of EBI2 affect the positioning and migration of B cells.", "Egr3 regulates the homeostasis of B and T cells.", "T cell receptor /CD3 microdomains are required to induce the immunologic synapse.", "The tip of the inner tube of the toxic type VI secretion system (T6SS) antibacterial effector in Escherichia coli (E. coli) is decorated with VgrG and PAAR proteins.", "Oxidative DNA damage activates STING signalling.", "Citrullinated proteins externalized in neutrophil extracellular traps act indirectly to disrupt the inflammatory cycle.", "Major antigen-induced signals from the T cell receptor and secondary signals from costimulatory receptors are required for T cell activation."], "hard_negative": "During the primary early antibody response activated B cells migrate toward the inner-and outer follicular areas where oxysterol accumulation is generated by stromal cells."}
{"query_id": "363", "query_text": "EG7 tumors can be killed by systemic oxaliplatin primed CD8+ T cells from the tumor-draining lymph node cells.", "negative": "Active Ly49Q prevents neutrophil polarization.", "negatives": ["Active Ly49Q prevents neutrophil polarization.", "Emodin forms hydrogen bonds with residues involved in PGAM1 substrate binding.", "HOXB4 is a highly expressed component of cellular secretome from fetal liver cell populations.", "One in five surgical randomized controlled trials are discontinued early.", "The proliferative capacity of neural progenitors differs across species.", "Foxp3 represses the expression of transcriptional regulators implicated in memory T cell development.", "Occipital activation levels are associated with auditory spatial performance in parietal regions of the brain.", "During non-homologous end joining, the ligation step is not as tolerant of disrepairs and other distortions when joining 3' of strand breaks as compared to 5' strand breaks.", "MICAL redox enzymes regulate actin dynamics.", "The effect of Lipopolysaccharides on kidney barrier function is dependent on inflammation levels."], "hard_negatives": ["EG7 tumors can be killed by systemic oxaliplatin primed CD8+ T cells from the tumor-draining lymph node cells.", "CD28 signals regulate trafficking of murine auto-reactive T cells into target tissues.", "IL-10 production by monocytes inhibits CD4 + T cell response.", "In melanoma, anti-CTLA-4 treatment reinvigorates exhausted PD-1+Eomes+CD8 T cells.", "Major antigen-induced signals from the T cell receptor and secondary signals from costimulatory receptors are required for T cell activation.", "CD28 initiates tonic signaling in conventional T cells, which causes an exhaustion phenotype and limited efficiency.", "Cancer cells can stimulate the accumulation of intra-tumoural myeloid-derived suppressor cells by promoting granulocyte colony stimulating factor production.", "A T helper 2 cell (Th2) environment impedes disease development in patients with systemic lupus erythematosus (SLE).", "Approximately 250,000 people are infected with human T-cell lymphotropic virus type 1 in the United Kingdom.", "Lice attenuated SIV vaccines induce a stronger antigen-specific T cell response in lymph node cells."], "hard_negative": "EG7 tumors can be killed by systemic oxaliplatin primed CD8+ T cells from the tumor-draining lymph node cells."}
{"query_id": "364", "query_text": "EGR2 is important to myelination of the peripheral nervous system.", "negative": "Toll-like receptor (TLR) signaling is involved in the pathogenesis of human MDS.", "negatives": ["Toll-like receptor (TLR) signaling is involved in the pathogenesis of human MDS.", "Microglia are an innate immune cell type of the central nervous system.", "Early patent ductus ateriosus (PDA) screening decreases in-hospital mortality.", "Lamins are found within the inner layer of the mitochondrial membrane of all cells.", "Genomic sequences involved in alternative splicing responsible for Hutchinson-Gilford progeria syndrome (HGPS) are abundant in the ''progerinonly'' allele of Lmna knock-in models.", "Alirocumab treatment reduces apo(a) fractional clearance rate.", "Pioglitazone use is significantly associated with an increased risk of prostate cancer.", "Removal of H3K9me3 improves reprogramming efficiency in human somatic cell nuclear transfer experiments.", "TNFAIP3 is a glioblastoma tumor enhancer.", "Integrating classroom-based collaborative learning with Web-based collaborative learning offers the best class performance."], "hard_negatives": ["EGR2 is important to myelination of the peripheral nervous system.", "Egr2 regulates the homeostasis of B and T cells.", "Egr3 regulates the homeostasis of B and T cells.", "MeCP2 influences the synaptic maturation of neurons.", "NR5A2 does not play a role in development of endometrial tissues.", "Tirasemtiv targets cardiac muscle.", "Varying expression levels of EBI2 affect the positioning and migration of B cells.", "Myelin sheaths play a role in action potential propagation.", "NR5A2 is important in reverse cholesterol transport in humans.", "Mice lacking Sirt1 in Sf1-expressing neurons are immune to diet-induced obesity and insulin resistance."], "hard_negative": "EGR2 is important to myelination of the peripheral nervous system."}
{"query_id": "365", "query_text": "ER-localized phosphatase Sac1 processes PI4P through coordination with OSBP and the endosome-localized protein sorting nexin 2.", "negative": "Bariatric surgery increases rates of postmenopausal breast cancer.", "negatives": ["Bariatric surgery increases rates of postmenopausal breast cancer.", "Incidence of heart failure increased by 10% in women since 1979.", "Physical activity level has no association with the difference in maximal oxygen consumption between black and white youth.", "Birth-weight is negatively associated with breast cancer.", "LRBA promotes CTLA - 4 recycling.", "MICAL redox enzymes regulate actin dynamics in many cell types.", "Over half of the gabonese children with Schimmelpenning-Feuerstein-Mims syndrome (SFM) had a plasma lactate of more than 5mmol/L.", "Destination container port throughput(CPT) is negatively related to dengue virus (DENV-1) diffusion in air traffic shipments.", "Foxk2 regulates autophagy genes in muscle cells and fibroblast cells.", "RANK-RANKL pathway signalling has no known association with development of Aire-expressing medullary thymic epithelial cells."], "hard_negatives": ["ER-localized phosphatase Sac1 processes PI4P through coordination with OSBP and the endosome-localized protein sorting nexin 2.", "Active caspase-11 participate in regulating phagosome-lysosome fusion.", "The NF-\u03baB essential modulator gene induces intestinal inflammation by promoting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death.", "Converting apoE4 to apoE3 by gene editing prevents the pathology associated with apoE4 in human iPSCderived neurons.", "The NF-\u03baB essential modulator gene prevents intestinal inflammation by inhibiting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death.", "APOE4 expression in iPSC-derived neurons results in decreased tau phosphorylation.", "Intramembrane cleavage by signal peptide peptidase aids in the degradation of proteins with a complex membrane orientation.", "Binding of p53 to enhancer regions (p53BERs) regulates the activity of p53 transcription and cell cycle arrest through the production of p53-dependent eRNAs.", "Converting apoE4 to apoE3 by gene editing worsens the pathology associated with apoE4 in human iPSCderived neurons.", "Ly49Q directs the organization of neutrophil polarization by regulating membrane raft functions."], "hard_negative": "ER-localized phosphatase Sac1 processes PI4P through coordination with OSBP and the endosome-localized protein sorting nexin 2."}
{"query_id": "366", "query_text": "ERAP1 SNPs are epistatic to HLA alleles for ankylosing spondylitis.", "negative": "DMS3 protein enables Pol V transcription in vivo.", "negatives": ["DMS3 protein enables Pol V transcription in vivo.", "Pyridostatin stabilizes the G - quadruplex in the telomeric region.", "Obesity raises life quality.", "Increased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm.", "The amount of publicly available DNA data doubles every 10 months.", "In patients with congenital heart defects, \u03b2-blockers significantly improve clinical heart failure outcomes.", "Diabetes remission occurs more in people treated with conventional therapy than in people treated with laparoscopic adjustable gastric banding surgery.", "A diminished ovarian reserve does not solely indicate infertility in an a priori non-infertile population.", "Converting apoE4 to apoE3 by gene editing worsens the pathology associated with apoE4 in human iPSCderived neurons.", "Intra-cerebroventricular infusion of amyloid-\u03b2 oligomers increases expression of fibronectin type-III domain-containing protein 5 mRNA in mice hippocampi."], "hard_negatives": ["ERAP1 SNPs are epistatic to HLA alleles for ankylosing spondylitis.", "Localization of PIN1 in the roots of Arabidopsis requires VPS9a", "KRT17 modulates the expression of the transcriptional regulator AIRE in diseased epithelia.", "N348I mutations cause resistance to nevirapine.", "HNF4A mutations are associated with macrosomia in infancy.", "N348I mutations reduce resistance to nevirapine.", "A high microerythrocyte count protects against severe anemia in homozygous alpha (+)- thalassemia trait subjects.", "Carriers of HNF4A mutations are at reduced risk for diabetes.", "Interleukin-18 plays an important role in the pathogenesis of atherosclerosis.", "Pseudogene PTENP1 encodes a transcript that regulates PTEN expression."], "hard_negative": "ERAP1 SNPs are epistatic to HLA alleles for ankylosing spondylitis."}
{"query_id": "367", "query_text": "Early patent ductus ateriosus (PDA) screening decreases in-hospital mortality.", "negative": "B3-Galectin decreases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR.", "negatives": ["B3-Galectin decreases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR.", "In young and middle-aged adults, current or remote uses of ADHD medications increase the risk of serious cardiovascular events.", "The minor G allele of FOXO3 up-regulates IL-10.", "Omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegetarians.", "The NF-\u03baB essential modulator gene induces intestinal inflammation by promoting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death.", "Rapid phosphotransfer rates are correlated with histidine kinase regulator specificity.", "TNFAIP3 is a glioblastoma tumor enhancer.", "MafA phosphorylation decreases its ubiquitination.", "Mutations in G-Beta protein GNB1 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.", "Mice are incapable of producing neutralizing antibodies in reponse to the Chikungunya virus (CHIKV) produced in mosquitos."], "hard_negatives": ["Early patent ductus ateriosus (PDA) screening increases in-hospital mortality.", "Early patent ductus ateriosus (PDA) screening decreases in-hospital mortality.", "CRP is positively correlated with postoperative mortality following Coronary Artery Bypass Graft (CABG) surgery.", "Including pharmacists in rounding teams reduces the incidence of adverse drug events (ADEs).", "Including pharmacists in rounding teams does not alter the incidence of adverse drug events (ADEs).", "Diabetic patients with acute coronary syndrome experience decreased short-term and long-term risk for bleeding events.", "Decreased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm.", "Ambulatory blood pressure monitoring is inaccurate at diagnosing hypertension.", "One in five surgical randomized controlled trials are discontinued early.", "Stroke patients with prior use of direct oral anticoagulants have a higher risk of in-hospital mortality than stroke patients with prior use of warfarin."], "hard_negative": "Early patent ductus ateriosus (PDA) screening increases in-hospital mortality."}
{"query_id": "368", "query_text": "Early patent ductus ateriosus (PDA) screening increases in-hospital mortality.", "negative": "Glial calcium waves influence seizures.", "negatives": ["Glial calcium waves influence seizures.", "Pyridostatin prevents double-strand breaks accumulation.", "Formation of N-terminal pyroglutamate by glutamine cyclase (GC) competes with NTAQ1 for Nt-Gln substrates.", "Destination container port throughput(CPT) is positively related to dengue virus (DENV-1) diffusion in air traffic shipments.", "Algerian physicians constitue the largest component of sub-Saharan Africa-trained physicians in the United States.", "At least 85% of patients exposed to radiation have activated markers of myofibroblasts.", "The proportion of people with visual difficulty is two times higher in low-income countries than in high-income countries.", "Medications to treat obesity do not have side effects.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have shorter lifetime exposure to estrogen due to a decreased reproductive period.", "Charcoal is an effective treatment for acute paraquat poisoning."], "hard_negatives": ["Early patent ductus ateriosus (PDA) screening increases in-hospital mortality.", "Early patent ductus ateriosus (PDA) screening decreases in-hospital mortality.", "CRP is positively correlated with postoperative mortality following Coronary Artery Bypass Graft (CABG) surgery.", "Including pharmacists in rounding teams reduces the incidence of adverse drug events (ADEs).", "Including pharmacists in rounding teams does not alter the incidence of adverse drug events (ADEs).", "Stroke patients with prior use of direct oral anticoagulants have a higher risk of in-hospital mortality than stroke patients with prior use of warfarin.", "Ambulatory blood pressure monitoring is inaccurate at diagnosing hypertension.", "Diabetic patients with acute coronary syndrome experience decreased short-term and long-term risk for bleeding events.", "Decreased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm.", "Cost effectiveness evaluations based on cRCT data accurately reflect prices for patients in actual clinical practice."], "hard_negative": "Early patent ductus ateriosus (PDA) screening increases in-hospital mortality."}
{"query_id": "369", "query_text": "Ectopic expression of Sall4, Nanog, Esrrb, and Lin28 generates induced pluripotent stem cells from mouse embryonic fibroblasts more efficiently than other factor combinations.", "negative": "Physical activity level is associated with the difference in maximal oxygen consumption between black and white youth.", "negatives": ["Physical activity level is associated with the difference in maximal oxygen consumption between black and white youth.", "Enhanced early production of inflammatory chemokines damages viral control in the lung.", "Self-advocacy training is effective at decreasing homelessness.", "A diminished ovarian reserve is a very strong indicator of infertility, even in an a priori non-infertile population.", "Reduction of purity of cytoplasmic membranes isolated from overexpressors is indicated by stronger spots for OmpA in 2D BN-PAGE gels.", "Antidepressants reduce the severity of migraines.", "There is no association between HNF4A mutations and diabetes risks.", "The PRR MDA5 has a C-terminal domain.", "The mean suicide rate in women is lower after miscarriage than live birth.", "Genes involved in pre-mRNA splicing have a significant impact on genome stability."], "hard_negatives": ["Ectopic expression of Sall4, Nanog, Esrrb, and Lin28 generates induced pluripotent stem cells from mouse embryonic fibroblasts more efficiently than other factor combinations.", "Addition of BMP4, activin A, CHIR99021, and SU504 to reprogramming fibroblasts generates, expands and maintains cardiovascular progenitor cells (CPCs)", "Specialized functional cell types can be derived from human pluripotent stem cells.", "Low expression of miR7a does not repress target genes or exert a biological function in testis.", "Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 encourage West Nile virus replication in cortical neurons.", "MICAL redox enzymes regulate actin dynamics in many cell types.", "Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 inhibit West Nile virus replication in cortical neurons.", "Mice lacking Sirt1 in Sf1-expressing neurons are immune to diet-induced obesity and insulin resistance.", "Activation of the Rac1 homolog CED-10 kills viable cells in SRGP-1 mutant Caenorhabditis elegans.", "Myelin sheaths are lipid-rich cellular structures."], "hard_negative": "Ectopic expression of Sall4, Nanog, Esrrb, and Lin28 generates induced pluripotent stem cells from mouse embryonic fibroblasts more efficiently than other factor combinations."}
{"query_id": "370", "query_text": "Egr2 regulates the homeostasis of B and T cells.", "negative": "A deficiency of vitamin B6 decreases blood levels of homocysteine.", "negatives": ["A deficiency of vitamin B6 decreases blood levels of homocysteine.", "Input from  mental and physical health care professionals is not effective at decreasing homelessness.", "Moderate consumption of candy and chocolate reduces the risk of cardiovascular disease (CVD).", "Taking 400mg of \u03b1-tocopheryl acetate does not prevent prostate cancer.", "Increased LDL receptors plays a role in the reduction of plasma Lp(a).", "miR-142-5P is a known regulator of raised body temperature.", "LRBA prevents CTLA - 4 recycling.", "Upregulation of PD1 causes the downmodulation of Satb1.", "Bacterial meningitis can be diagnosed on the basis of positive cerebrospinal fluid (CSF) cultures.", "Differentiated E2f-1, -2, -3 TKO cells in the intestine do not exhibit apoptosis."], "hard_negatives": ["Egr2 regulates the homeostasis of B and T cells.", "Egr3 regulates the homeostasis of B and T cells.", "EGR2 is important to myelination of the peripheral nervous system.", "Varying expression levels of EBI2 affect the positioning and migration of B cells.", "Major antigen-induced signals from the T cell receptor and secondary signals from costimulatory receptors are required for T cell activation.", "Reduced responsiveness to interleukin-2 in regulatory T cells is associated with autoimmune diseases such as Type 1 Diabetes.", "B cells go though plasmablast differentiation and antibody production by continuous expression of EBI2.", "CD28 signals regulate trafficking of murine auto-reactive T cells into target tissues.", "IL-10 production by monocytes inhibits CD4 + T cell response.", "Foxk2 regulates autophagy genes in muscle cells and fibroblast cells."], "hard_negative": "Egr2 regulates the homeostasis of B and T cells."}
{"query_id": "371", "query_text": "Egr3 regulates the homeostasis of B and T cells.", "negative": "Osteocytes have an essential role in G-CSF induced HSPC mobilization.", "negatives": ["Osteocytes have an essential role in G-CSF induced HSPC mobilization.", "The proliferative capacity of neural progenitors differs across species.", "Oxidative DNA damage activates STING signalling.", "During non-homologous end joining, the ligation step is not as tolerant of disrepairs and other distortions when joining 5' of strand breaks as compared to 3' strand breaks.", "Pre-mRNAs associated with spliceosomal components are more stable than unassociated splicing substrates.", "The gene daf-16, which encodes forkhead Box O (FOXO), is required for all phenotypes associated with reduced insulin/insulin-like growth factor (Igf) signaling.", "Distant CREs are less conserved among species.", "Antimicrobial agents are more effective due to the pressure of antimicrobial usage.", "RUNX1 is downregulated or mutated in TLX1 T-ALL.", "Bariatric surgery increases rates of colorectal cancer."], "hard_negatives": ["Egr3 regulates the homeostasis of B and T cells.", "Egr2 regulates the homeostasis of B and T cells.", "GATA3 regulates cell cycle progression in bone marrow hematopoietic stem cells.", "EGR2 is important to myelination of the peripheral nervous system.", "Major antigen-induced signals from the T cell receptor and secondary signals from costimulatory receptors are required for T cell activation.", "CD28 signals regulate trafficking of murine auto-reactive T cells into target tissues.", "Varying expression levels of EBI2 affect the positioning and migration of B cells.", "GATA3 regulates self-renewal capacity in bone marrow hematopoietic stem cells.", "Reduced responsiveness to interleukin-2 in regulatory T cells is associated with autoimmune diseases such as Type 1 Diabetes.", "IL-10 production by monocytes inhibits CD4 + T cell response."], "hard_negative": "Egr3 regulates the homeostasis of B and T cells."}
{"query_id": "372", "query_text": "Eilat virus (EILV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in nonhuman primates.", "negative": "The density of cytokine receptor bearing cells has no effect on the distance over which cytokines act.", "negatives": ["The density of cytokine receptor bearing cells has no effect on the distance over which cytokines act.", "qSOFA scores are associated with length of stay in emergency department patients.", "Guanine nucleotide dissociation inhibitor (Rho-GDI) interacts with the p75 NTR death domain", "Oxidative DNA damage activates STING signalling.", "Glucose restriction to 0.05% reduces RLS (replicative life span) by 20-40% in S. cerevisiae.", "Ly49Q directs the organization of neutrophil polarization by regulating membrane raft functions.", "The latent infection of myeloid cells with human cytomegalovirus induces a number of changes in gene expression.", "Weighed food records (WFR) result in high completion since they're cheap to run and impose low participant burden.", "Migraine with aura is associated with ischemic stroke.", "Replacement of OCT4 and SOX2 genes with GATA3 has the ability to reprogram human cells."], "hard_negatives": ["Eilat virus (EILV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in nonhuman primates.", "Nonhuman primates are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.", "Mice are incapable of producing neutralizing antibodies in reponse to the Chikungunya virus (CHIKV) produced in mosquitos.", "Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 inhibit West Nile virus replication in cortical neurons.", "Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 encourage West Nile virus replication in cortical neurons.", "Malaria has a high vectorial capacity.", "The latent infection of myeloid cells with human cytomegalovirus induces a number of changes in gene expression.", "Rising temperatures caused by global warming increases risk of dengue fever transmission.", "In rhesus macaques, daily subcutaneous injections of emtricitabine are ineffective at protecting against rectally transmitted simian-human immunodeficiency virus.", "Rising temperatures caused by global warming lowers the risk of dengue fever transmission."], "hard_negative": "Eilat virus (EILV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in nonhuman primates."}
{"query_id": "375", "query_text": "Elevated cell-free mitochondrial DNA levels are associated with mortality.", "negative": "Induced hepatic stem cells possess the potential to differentiate into hepatocytic cells.", "negatives": ["Induced hepatic stem cells possess the potential to differentiate into hepatocytic cells.", "The predominant localization of Linc00173 is in mononuclear macrophage nuclei.", "Pyridostatin reduces proliferation of homologous recombination - defective cells.", "76-85% of people with severe mental disorder receive no treatment in low and middle income countries.", "70% of burn patients are admitted for hospitalization and further treatment after appearing at hospital emergency wards or outpatient clinics.", "Incidence of 10/66 dementia is higher than the incidence of DSM-IV dementia.", "Lamins are found within the inner layer of the mitochondrial membrane of all cells.", "The origin of the CRF01_1b2k protein occurred between 1923 and 1956.", "Pediatric SCD patients with vaso-occlusive crisis show increased morphine use after breathing 80 ppm iNO for 4 hours.", "Inhibiting HDAC6 increases survival of mice with ARID1A mutated tumors."], "hard_negatives": ["Elevated cell-free mitochondrial DNA levels are associated with mortality.", "Immune complex triggered cell death leads to sequestration of oxidized mitochondrial DNA.", "A deficiency of vitamin B12 decreases blood levels of homocysteine.", "The generation of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells.", "The removal of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells.", "53% of perinatal mortality is due to low birth weight.", "Suboptimal nutrition is a leading cause of premature death", "10% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.", "A deficiency of vitamin B6 decreases blood levels of homocysteine.", "A deficiency of folate increases blood levels of homocysteine."], "hard_negative": "Elevated cell-free mitochondrial DNA levels are associated with mortality."}
{"query_id": "376", "query_text": "Eliminating the last sporadic cases of malaria requires considerable funding.", "negative": "Active Ly49Q induces neutrophil polarization.", "negatives": ["Active Ly49Q induces neutrophil polarization.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have shorter lifetime exposure to estrogen due to a decreased reproductive period.", "Acute ablation of KRAS causes severe growth impairment.", "Transcription rates in S. cerevisiae range between 7 and 12 kb/min.", "Environmentally-induced senescence is mimicked in disease modeling by adding specific molecules to the culture system.", "The origin of the CRF01_1b2k protein occurred between 1923 and 1956.", "Lamins have no effect on nuclear membrane structure maintenance.", "Cis-acting lncRNAs control the expression of genes that are positioned in the vicinity of their transcription sites.", "CD28 initiates tonic signaling in conventional T cells, which causes an exhaustion phenotype and limited efficiency.", "VgrG (Tssl) protein punctures membranes by forming a spike at the tip of the tube apparatus."], "hard_negatives": ["Eliminating the last sporadic cases of malaria requires considerable funding.", "Malaria has a high vectorial capacity.", "Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission.", "Rising temperatures caused by global warming lowers the risk of dengue fever transmission.", "Rising temperatures caused by global warming increases risk of dengue fever transmission.", "Urbanization is an important risk factor related to the transmission of dengue fever.", "The World Health Organization's (WHO) data collection process is biased downward by unequal selection of larger outbreaks.", "76-85% of people with severe mental disorder receive no treatment in low and middle income countries.", "Antiretroviral therapy increases rates of tuberculosis across a broad range of CD4 strata.", "Patients in stable partnerships progress from HIV to death at the same rate as patients not in partnerships."], "hard_negative": "Eliminating the last sporadic cases of malaria requires considerable funding."}
{"query_id": "377", "query_text": "Emodin forms hydrogen bonds with residues involved in PGAM1 substrate binding.", "negative": "In pediatric tissue, most T cells are naive T cell emigrants from the thymus.", "negatives": ["In pediatric tissue, most T cells are naive T cell emigrants from the thymus.", "COPI coatmer is involved in lipid homeostasis.", "Bariatric surgery reduces colorectal cancer.", "The TRaF1/C5 rs10818488 allele polymorphism regulates the neighboring C5 gene.", "Monoclonal antibody targeting of N-cadherin encourages castration resistance.", "The HSV-2 infection is typically asymptomatic.", "Genes involved in pre-mRNA splicing have a significant impact on genome stability.", "Foxk2 regulates autophagy genes in muscle cells and fibroblast cells.", "ATF4 is a general endoplasmic reticulum stress marker.", "De novo assembly of sequence data has fewer specific contigs than unassembled sequence data."], "hard_negatives": ["Emodin forms hydrogen bonds with residues involved in PGAM1 substrate binding.", "The PPR MDA5 has twenty N-terminal CARD domains.", "Localization of PIN1 in the roots of Arabidopsis requires VPS9a", "Formation of N-terminal pyroglutamate by glutamine cyclase (GC) competes with NTAQ1 for Nt-Gln substrates.", "The artifactual C-terminal helix swapping in the StART domain is observed in the Ups1-Mdm35 heterodimer of the StARkin superfamily.", "MafA ubiquitination increases the recruitment of coavtivator P/CAF by MafA.", "MafA phosphorylation enhances its ubiquitination.", "The microtubule-dependent delivery and secretion of matrix metalloproteases (MMPs) is partially responsible for the disassembly of adhesion sites.", "Mutations in RIM1 decrease levels of IME1 RNA.", "C2 works synergistically with A-769662 to activate dephosphorylated AMPK."], "hard_negative": "Emodin forms hydrogen bonds with residues involved in PGAM1 substrate binding."}
{"query_id": "378", "query_text": "Energy balance requires hypothalamic glutamate neurotransmission.", "negative": "Ribosome-inactivating protein-2 (RIP-2) interacts with the p75 NTR death domain", "negatives": ["Ribosome-inactivating protein-2 (RIP-2) interacts with the p75 NTR death domain", "MICAL redox enzymes regulate actin dynamics in many cell types.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have decreased risk for dementia.", "Increased microtubule acetylation repairs interference of axonal transport caused by LRRK2 Roc-COR domain mutations.", "Activator-inhibitor pairs are provided ventrally by Xrl-sizzled.", "Transcription factor EB induces transcription of pro-inflammatory cytokines in macrophages infected with Staphylococcus aureus.", "Inhibiting focal adhesion formation enables cells to convert mechanical strain into eventual scarring.", "Removal of H3K9me3 by ectopic expression of other H3K9 demethylases improves reprogramming efficiency in SCNT experiments.", "Forkhead 0 (fox0) transcription factors are involved in apoptosis.", "DUSP4 downregulation deactivates the Ras-ERK pathway"], "hard_negatives": ["Energy balance requires hypothalamic glutamate neurotransmission.", "Hypothalamic glutamate neurotransmission is unrelated to energy balance.", "Insulin effects appetite via ventral tegmental neurons.", "Rhythmic expression of Cry1 translates directly into a circadian regulation of cAMP signaling in hepatic glucose metabolism.", "Increased lipolysis leads to higher P38 phosphorylation in adipose tissue.", "Oxidative phosphorylation is one of the primary glycometabolic pathways in cells.", "Glial calcium waves influence seizures.", "Occipital activation levels are associated with auditory spatial performance in parietal regions of the brain.", "Reduced levels of lipolysis leads to higher P38 phosphorylation in adipose tissue.", "Rhythmic expression of Cry1 translates directly into a circadian regulation of cAMP signaling in gluconeogenesis."], "hard_negative": "Energy balance requires hypothalamic glutamate neurotransmission."}
{"query_id": "379", "query_text": "Enhanced early production of inflammatory chemokines damages viral control in the lung.", "negative": "Surgical treatment is not superior to non-surgical in treating adults with displaced fractures of the proximal humerus.", "negatives": ["Surgical treatment is not superior to non-surgical in treating adults with displaced fractures of the proximal humerus.", "Systemic lupus erythematosus is a risk factor for cardiovascular disease.", "BRCA 1 mutation carriers' risk of breast and ovarian cancer depends on where the mutation is located.", "Insulin decreases risk of severe kidney failure.", "Monoclonal antibody targeting of N-cadherin inhibits growth.", "Bacteriophagaes MS2 and Q\u03b2 are members of the Leviviridae.", "F4/80+ macrophages regulate mature osteoblast maintenance.", "Physical activity level has no association with the difference in maximal oxygen consumption between black and white youth.", "Allogeneic mechanical circulatory support is not as effective as autologous mechanical circulatory support for treating acute myocardial infarction.", "Eliminating the last sporadic cases of malaria requires considerable funding."], "hard_negatives": ["Enhanced early production of inflammatory chemokines damages viral control in the lung.", "Upon viral challenge, influenza-specific memory CD4+ T cells greatly diminish the early production of inflammatory chemokines in the lung.", "Upon viral challenge, influenza-specific memory CD4+ T cells greatly enhance the early production of inflammatory chemokines in the lung.", "The deregulated and prolonged activation of monocytes improves inflammatory disease outcomes.", "AMP-activated protein kinase (AMPK) activation reduces inflammation-related fibrosis in the lungs.", "Systemic immunosuppressive (IS) therapy increases the chance of cancer mortality in patients with inflammatory eye disease (IED)", "The latent infection of myeloid cells with human cytomegalovirus induces a number of changes in gene expression.", "Primary pro-inflammatory cytokines suppress secondary pro- and anti-inflammatory mediators.", "Systemic immunosuppressive (IS) therapy does not enhance the chance of cancer mortality in patients with inflammatory eye disease (IED)", "Citrullinated proteins externalized in neutrophil extracellular traps act indirectly to perpetuate the inflammatory cycle via induction of autoantibodies."], "hard_negative": "Enhanced early production of inflammatory chemokines damages viral control in the lung."}
{"query_id": "381", "query_text": "Environmental factors can influence the development of breast cancer.", "negative": "Microcin J25 encourages nucleoside triphosphate (NTP) binding.", "negatives": ["Microcin J25 encourages nucleoside triphosphate (NTP) binding.", "Upon developing tyrosine-kinase inhibitor resistance, new mutations in epidermal growth factor receptors emerge and cause treatment failure.", "Oxidative DNA damage activates STING signalling.", "Microglia are an innate immune cell type of the central nervous system.", "Occipital activation levels are associated with auditory spatial performance in parietal regions of the brain.", "Having a main partner worsens HIV outcomes.", "Increased flux of microbial products suppresses immune responses.", "Aged patients are more susceptible to ischaemia/reperfusion injury.", "Dscam1 acts as a hypervariable pattern-recognition receptor for the immune system.", "Cell autonomous sex determination in somatic cells occurs in Galliformes."], "hard_negatives": ["Environmental factors can influence the development of breast cancer.", "Women with a lower birth weight are more likely to develop breast cancer later in life.", "The risk of breast cancer among parous women decreases with placental weight of pregnancies.", "In breast cancer, the loss of myoepithelial cells promotes the transition of ductal carcinoma in situ to invasive carcinoma.", "In breast cancer, the loss of myoepithelial cells slows the transition of ductal carcinoma in situ to invasive carcinoma.", "A breast cancer patient's capacity to metabolize tamoxifen influences treatment outcome.", "Birth-weight is negatively associated with breast cancer.", "Many cytokines that are produced by cancer cells also contribute to carcinogenesis.", "Ten percent (10%) of kidney cancers in the UK are attributable to excess weight.", "Cancers that initially benefit from epidermal growth factor receptor targeted therapies later become refractory through several mechanisms."], "hard_negative": "Environmental factors can influence the development of breast cancer."}
{"query_id": "382", "query_text": "Environmentally-induced senescence is mimicked in disease modeling by adding specific molecules to the culture system.", "negative": "Female carriers of the Apolipoprotein E4 (APOE4) allele have longer lifetime exposure to estrogen due to an increased reproductive period.", "negatives": ["Female carriers of the Apolipoprotein E4 (APOE4) allele have longer lifetime exposure to estrogen due to an increased reproductive period.", "Increased mobility of retrotransposons is assosciated with mutation and higher tumorigenesis rates.", "In the UK, drowning affects boys and girls equally.", "Activation of PPM1D enhances p53 function.", "Omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegetarians.", "Ethanol stress increases the expression of IBP in bacteria.", "Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission.", "The density of cytokine receptor bearing cells affects the distance over which cytokines act.", "Forkhead 0 (fox0) transcription factors are involved in apoptosis.", "Stroke patients with prior use of direct oral anticoagulants have a higher risk of in-hospital mortality than stroke patients with prior use of warfarin."], "hard_negatives": ["Environmentally-induced senescence is mimicked in disease modeling by adding specific molecules to the culture system.", "The proliferative capacity of progenitors is regulated cell-autonomously.", "eRNAs influence is linked to senescence, aging, and carcinogenesis.", "The proliferative capacity of neural progenitors differs across species.", "Progerin induces premature aging in stem cells.", "Cancers that initially benefit from epidermal growth factor receptor targeted therapies later become refractory through several mechanisms.", "Upon developing tyrosine-kinase inhibitor resistance, new mutations in epidermal growth factor receptors emerge and cause treatment failure.", "Autophagy deficiency in the liver increases vulnerability to insulin resistance.", "Pure neural progenitor cell (NPC) populations can only be obtained from cell cultures that undergo passaging, filtration, or other isolation and cell sorting methods.", "Ethanol stress increases the expression of PSP in bacteria."], "hard_negative": "Environmentally-induced senescence is mimicked in disease modeling by adding specific molecules to the culture system."}
{"query_id": "383", "query_text": "Epidemiological disease burden from noncommunicable diseases is more prevalent in high economic settings.", "negative": "PrimPol generates short DNA replication intermediates on the leading strand during DNA replication.", "negatives": ["PrimPol generates short DNA replication intermediates on the leading strand during DNA replication.", "Incidence of 10/66 dementia is lower than the incidence of DSM-IV dementia.", "Side effects associated with antidepressants lower risk of myocardial infarction.", "Vaccinating the gastrointestinal tract induces protection of rectal and vaginal mucosa.", "Eilat virus (EILV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in nonhuman primates.", "Albendazole is used to treat soil-transmitted helminths.", "Genes regulated by Esrrb transcription factor are sensitive to Mbd3 function.", "Cellular clocks are not predictive of mitosis timing in NIH 3T3 cells.", "ITAM phosphorylation allows for the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).", "Intramembrane cleavage by signal peptide peptidase aids in the degradation of proteins with a complex membrane orientation."], "hard_negatives": ["Epidemiological disease burden from noncommunicable diseases is more prevalent in high economic settings.", "Malaria has a high vectorial capacity.", "Rising temperatures caused by global warming increases risk of dengue fever transmission.", "Rising temperatures caused by global warming lowers the risk of dengue fever transmission.", "Urbanization is an important risk factor related to the transmission of dengue fever.", "The innate immune response struggles to remove small numbers of parasites.", "Suboptimal nutrition is a leading cause of premature death", "76-85% of people with severe mental disorder receive no treatment in low and middle income countries.", "Sepsis related mortality has risen from 2009 to 2014.", "The World Health Organization's (WHO) data collection process is biased downward by unequal selection of larger outbreaks."], "hard_negative": "Epidemiological disease burden from noncommunicable diseases is more prevalent in high economic settings."}
{"query_id": "389", "query_text": "Ethanol stress increases the expression of IBP in bacteria.", "negative": "Mice without IFN-\u03b3 or its receptor are highly susceptible to EAM induced with \u03b1-MyHC/CFA.", "negatives": ["Mice without IFN-\u03b3 or its receptor are highly susceptible to EAM induced with \u03b1-MyHC/CFA.", "Replacement of OCT4 and SOX2 genes with GATA3 is not capable of reprogramming human cells.", "A country's Vaccine Alliance (GAVI) eligibility is not indictivate of accelerated adoption of the Hub vaccine.", "Hematopoietic Stem Cell purification reaches purity rates above 90%.", "VgrG (Tssl) protein punctures membranes by forming a spike at the tip of the tube apparatus.", "53% of perinatal mortality is due to low birth weight.", "Polymeal nutrition increases cardiovascular mortality.", "In domesticated populations of Saccharomyces cerevisiae, segmental aneuploidy occurs infrequently.", "Primary cervical cytology screening with HPV detection has higher longitudinal sensitivity to detect severe cervical intraepithelial neoplasia than conventional cytology.", "Deletion of ATM and Rad3 related protein is not predictive of acute tissue loss."], "hard_negatives": ["Ethanol stress increases the expression of IBP in bacteria.", "Ethanol stress increases the expression of PSP in bacteria.", "Ethanol stress lowers the expression of PSP in bacteria.", "Ethanol stress increases the expression of SRL in bacteria.", "Ethanol stress reduces the expression of SRL in bacteria.", "Autophagy deficiency in the liver increases vulnerability to insulin resistance.", "The Snf1 complex regulates carbon and energy metabolism in baker's yeast (Saccharomyces cerevisiae).", "The generation of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells.", "Oxidative phosphorylation is one of the primary glycometabolic pathways in cells.", "The removal of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells."], "hard_negative": "Ethanol stress increases the expression of IBP in bacteria."}
{"query_id": "390", "query_text": "Ethanol stress increases the expression of PSP in bacteria.", "negative": "p75 NTR - associated cell death executor (NADE) interacts with the p75 NTR death domain", "negatives": ["p75 NTR - associated cell death executor (NADE) interacts with the p75 NTR death domain", "Long chain polyunsaturated fatty acids supplementation is associated with lower rates of atopic eczema at 1 year.", "Inhibiting HDAC6 increases survival of mice with ARID1A mutated tumors.", "Gastric lavage is an effective treatment for acute paraquat poisoning.", "Foxp3 enables the expression of transcriptional regulators implicated in memory T cell development.", "Klf4 is not required for proper myeloid cell differentiation.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have longer lifetime exposure to estrogen due to an increased reproductive period.", "Increase of p62 in prostate tumor stroma results in defective autophagy.", "Pediatric SCD patients with vaso-occlusive crisis show increased morphine use after breathing 80 ppm iNO for 4 hours.", "Pyridostatin deregulates G2/M progression."], "hard_negatives": ["Ethanol stress increases the expression of PSP in bacteria.", "Ethanol stress lowers the expression of PSP in bacteria.", "Ethanol stress increases the expression of SRL in bacteria.", "Ethanol stress reduces the expression of SRL in bacteria.", "Ethanol stress increases the expression of IBP in bacteria.", "AMP-activated protein kinase (AMPK) activation reduces inflammation-related fibrosis in the lungs.", "Autophagy deficiency in the liver increases vulnerability to insulin resistance.", "The generation of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells.", "Rhythmic expression of Cry1 translates directly into a circadian regulation of cAMP signaling in hepatic glucose metabolism.", "The removal of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells."], "hard_negative": "Ethanol stress increases the expression of PSP in bacteria."}
{"query_id": "391", "query_text": "Ethanol stress increases the expression of SRL in bacteria.", "negative": "LSD1-positive promoters are associated with RNA polymerase II", "negatives": ["LSD1-positive promoters are associated with RNA polymerase II", "Students who perform poorly in the early years of medical school are less likely to commit professional misconduct later in their careers.", "The ability of activator E2Fs in preventing cell death is limited to terminally differentiated cells.", "Upregulation of dynein in Drosophila neurons increases the number of microtubule plus-ends growing toward the cell body of each neuron.", "Increased lipolysis leads to higher P38 phosphorylation in adipose tissue.", "Mice defective for deoxyribonucleic acid (DNA) polymerase m (polm) reveal increased sensitivity to ionizing radiation (IR).", "DUSP4 increases apoptosis.", "The PDPN gene deactivates the C-type lectin receptor (CLEC-2).", "Immune complex triggered cell death leads to sequestration of oxidized mitochondrial DNA.", "Long chain polyunsaturated fatty acids supplementation is associated with lower rates of atopic eczema at 1 year."], "hard_negatives": ["Ethanol stress increases the expression of SRL in bacteria.", "Ethanol stress reduces the expression of SRL in bacteria.", "Ethanol stress increases the expression of PSP in bacteria.", "Ethanol stress lowers the expression of PSP in bacteria.", "Ethanol stress increases the expression of IBP in bacteria.", "The generation of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells.", "The M2-phenotype in brown adipose tissue macrophages increases brown adipose tissue thermogenic activity.", "Glucose restriction to 0.05% reduces RLS (replicative life span) by 20-40% in S. cerevisiae.", "The removal of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells.", "An M2-like phenotype in brown adipose tissue macrophages is quickly induced by cold exposure."], "hard_negative": "Ethanol stress increases the expression of SRL in bacteria."}
{"query_id": "392", "query_text": "Ethanol stress lowers the expression of PSP in bacteria.", "negative": "miR-142-5P is a known regulator of raised body temperature.", "negatives": ["miR-142-5P is a known regulator of raised body temperature.", "LDL cholesterol has a causal role in the development of cardiovascular disease.", "Microcin J25 inhibits nucleoside triphosphate (NTP) binding.", "RUNX is not expressed in skin tissue.", "Ca2+ cycling is a UCP1-dependent thermogenic mechanism.", "Pure neural progenitor cell (NPC) populations can only be obtained from cell cultures that undergo passaging, filtration, or other isolation and cell sorting methods.", "The DESMOND program demonstrates no significant impact on biochemical outcomes.", "Healthy volunteers exhibit rapid and transient increase of cellular ATP after being bolus-injected with fructose.", "Active caspase-11 participate in regulating phagosome-lysosome fusion.", "Patients in stable partnerships progress from HIV to death at the same rate as patients not in partnerships."], "hard_negatives": ["Ethanol stress lowers the expression of PSP in bacteria.", "Ethanol stress increases the expression of PSP in bacteria.", "Ethanol stress reduces the expression of SRL in bacteria.", "Ethanol stress increases the expression of SRL in bacteria.", "Ethanol stress increases the expression of IBP in bacteria.", "The generation of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells.", "AMP-activated protein kinase (AMPK) activation reduces inflammation-related fibrosis in the lungs.", "Autophagy deficiency in the liver increases vulnerability to insulin resistance.", "The removal of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells.", "Rhythmic expression of Cry1 translates directly into a circadian regulation of cAMP signaling in hepatic glucose metabolism."], "hard_negative": "Ethanol stress lowers the expression of PSP in bacteria."}
{"query_id": "393", "query_text": "Ethanol stress reduces the expression of SRL in bacteria.", "negative": "Transcription factor EB induces transcription of pro-inflammatory cytokines in macrophages infected with Staphylococcus aureus.", "negatives": ["Transcription factor EB induces transcription of pro-inflammatory cytokines in macrophages infected with Staphylococcus aureus.", "Ambulatory blood pressure monitoring is inaccurate at diagnosing hypertension.", "Risedronate increases risk of vertebral and non-vertebral fractures.", "Decrease of p62 in prostate tumor stroma results in defective autophagy.", "Moderate consumption of candy and chocolate reduces the risk of cardiovascular disease (CVD).", "Bacterial meningitis can be diagnosed on the basis of positive cerebrospinal fluid (CSF) cultures.", "Surfactin producing cells and exopolymer producing cells cooperate to generate \"Van Gogh\" bundles that have sliding abilities on specialized media.", "Diabetic patients with acute coronary syndrome experience decreased short-term and long-term risk for bleeding events.", "Glycan adaptation is rarely observed in the B-cell repertoire.", "Improvements in OER catalysts show stable activity over several hundred hours."], "hard_negatives": ["Ethanol stress reduces the expression of SRL in bacteria.", "Ethanol stress increases the expression of SRL in bacteria.", "Ethanol stress increases the expression of PSP in bacteria.", "Ethanol stress lowers the expression of PSP in bacteria.", "Ethanol stress increases the expression of IBP in bacteria.", "Glucose restriction to 0.05% reduces RLS (replicative life span) by 20-40% in S. cerevisiae.", "The generation of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells.", "The removal of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells.", "The M2-phenotype in brown adipose tissue macrophages increases brown adipose tissue thermogenic activity.", "An M2-like phenotype in brown adipose tissue macrophages is quickly induced by cold exposure."], "hard_negative": "Ethanol stress reduces the expression of SRL in bacteria."}
{"query_id": "394", "query_text": "Excess gestational weight gain is associated with obesity-related pregnancy outcomes.", "negative": "Guanine nucleotide exchange factors (GEFs) mediate RhoA activation in response to tensional forces on fibronectin-binding integrins.", "negatives": ["Guanine nucleotide exchange factors (GEFs) mediate RhoA activation in response to tensional forces on fibronectin-binding integrins.", "G-CSF increases the expansion and infiltration of MDSCs into tumors.", "1 in 5 million in UK have abnormal PrP positivity.", "Up-regulation of the p53 pathway and related molecular events speeds cancer progression.", "Microcin J25 encourages nucleoside triphosphate (NTP) binding.", "Increased conversion of PGE 2 to PPARy ligand 15-ket-PGE 2 causes accumulation of PGE.", "Headaches are correlated with cognitive impairment.", "The mean suicide rate in women is higher after miscarriage than live birth.", "B3-Galectin increases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR.", "Surgical treatment is not superior to non-surgical in treating adults with displaced fractures of the proximal humerus."], "hard_negatives": ["Excess gestational weight gain is associated with obesity-related pregnancy outcomes.", "Birth-weight is negatively associated with breast cancer.", "Women with a lower birth weight are more likely to develop breast cancer later in life.", "The risk of breast cancer among parous women decreases with placental weight of pregnancies.", "Medications to treat obesity do not have side effects.", "53% of perinatal mortality is due to low birth weight.", "Medications to treat obesity have unwanted side effects.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have shorter lifetime exposure to estrogen due to a decreased reproductive period.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have longer lifetime exposure to estrogen due to an increased reproductive period.", "Vitamin D deficiency effects birth weight."], "hard_negative": "Excess gestational weight gain is associated with obesity-related pregnancy outcomes."}
{"query_id": "396", "query_text": "Exercise increases cancer mortality rates among Chinese citizens.", "negative": "53% of perinatal mortality is due to low birth weight.", "negatives": ["53% of perinatal mortality is due to low birth weight.", "Lamins are associated with nuclear membrane structure maintenance.", "CDK6 shows impaired binding to loss-of-function variants of p18 INK4C.", "Upon viral challenge, influenza-specific memory CD4+ T cells greatly diminish the early production of inflammatory chemokines in the lung.", "Approximately 250,000 people are infected with human T-cell lymphotropic virus type 1 in the United Kingdom.", "Glial calcium waves influence seizures.", "A diminished ovarian reserve is a very strong indicator of infertility, even in an a priori non-infertile population.", "The minor G allele of FOXO3 is related to less severe symptoms of Crohn's Disease.", "Transplanted human glial progenitor cells can mature in their host animal.", "Varenicline monotherapy is more effective after 26 weeks of treatment compared to combination nicotine replacement therapies with varenicline or bupropion."], "hard_negatives": ["Exercise increases cancer mortality rates among Chinese citizens.", "Exercise reduces cancer mortality rates among Chinese citizens.", "The risk of cancer rises with level of alcohol consumption.", "Women with a lower birth weight are more likely to develop breast cancer later in life.", "Medications to treat obesity have unwanted side effects.", "Participants who quit smoking reduce lung cancer risk by approximately 50%.", "Excess gestational weight gain is associated with obesity-related pregnancy outcomes.", "Medications to treat obesity do not have side effects.", "Walking in traffic areas in London improves lung function in elderly adults.", "Obesity decreases life quality."], "hard_negative": "Exercise increases cancer mortality rates among Chinese citizens."}
{"query_id": "397", "query_text": "Exercise reduces cancer mortality rates among Chinese citizens.", "negative": "It is not proven that moderate consumption of candy and chocolate reduces the risk of cardiovascular disease (CVD) specifically.", "negatives": ["It is not proven that moderate consumption of candy and chocolate reduces the risk of cardiovascular disease (CVD) specifically.", "Systemic lupus erythematosus is a risk factor for cardiovascular disease.", "Induced hepatic stem cells possess the potential to differentiate into hepatocytic cells.", "AMP-activated protein kinase (AMPK) activation reduces inflammation-related fibrosis in the lungs.", "Mice lacking Sirt1 in Sf1-expressing neurons have increased susceptibility to diet-induced obesity and insulin resistance.", "5'-nucleotidase metabolizes 6MP.", "DUSP4 decreases apoptosis.", "Low nucleosome occupancy correlates with high methylation levels across species.", "M. stadtmanae induces ASC speck formation in BlaER1 monocytes.", "Formation of N-terminal pyroglutamate by glutamine cyclase (GC) competes with NTAQ1 for Nt-Gln substrates."], "hard_negatives": ["Exercise reduces cancer mortality rates among Chinese citizens.", "Exercise increases cancer mortality rates among Chinese citizens.", "The risk of cancer rises with level of alcohol consumption.", "Women with a lower birth weight are more likely to develop breast cancer later in life.", "Participants who quit smoking reduce lung cancer risk by approximately 50%.", "Medications to treat obesity have unwanted side effects.", "Walking in traffic areas in London improves lung function in elderly adults.", "Obesity decreases life quality.", "Excess gestational weight gain is associated with obesity-related pregnancy outcomes.", "Obesity raises life quality."], "hard_negative": "Exercise reduces cancer mortality rates among Chinese citizens."}
{"query_id": "398", "query_text": "Exhaustion of B cells contributes to poor Ab response in HIV-infected individuals.", "negative": "Sepsis related mortality has risen from 2009 to 2014.", "negatives": ["Sepsis related mortality has risen from 2009 to 2014.", "Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection increases dissemination of Salmonella Typhimurium from the gut.", "Integrated care is ineffective at tackling multiple comorbidities.", "PrimPol degrades short DNA replication intermediates on the leading strand during DNA replication.", "50% of patients exposed to radiation have activated markers of mesenchymal stem cells.", "Cis-acting lncRNAs control the expression of genes that are positioned in the vicinity of their transcription sites.", "Human embryonic stem cells give rise to cell types from all three embryonic germ layers.", "There is a positive correlation between hip fractures and statin use.", "VgrG (Tssl) protein punctures membranes by forming a spike at the tip of the tube apparatus.", "In domesticated populations of Saccharomyces cerevisiae, segmental aneuploidy occurs infrequently."], "hard_negatives": ["Exhaustion of B cells contributes to poor Ab response in HIV-infected individuals.", "Chronic HIV stimulation of B cells leads to the premature exhaustion of B cells.", "Antiretroviral therapy increases rates of tuberculosis across a broad range of CD4 strata.", "Taking anti-depresents is associated with a decrease in the A\u03b2 level in the brain of experimental animals.", "Having a main partner worsens HIV outcomes.", "Patients in stable partnerships progress from HIV to death at the same rate as patients not in partnerships.", "Patients in stable partnerships have a slower progression from HIV to AIDS.", "Tuberculosis-induced granulomas express different immune system protein signatures than the surrounding tissue.", "A low percentage of hematopoietic progenitor cells are susceptible to HIV-1 infection ex vivo.", "ART substantially reduces infectiveness of HIV-positive people."], "hard_negative": "Exhaustion of B cells contributes to poor Ab response in HIV-infected individuals."}
{"query_id": "400", "query_text": "Exposure to fine particulate air pollution is unrelated to anxiety prevalence.", "negative": "Acute ablation of KRAS causes severe growth impairment.", "negatives": ["Acute ablation of KRAS causes severe growth impairment.", "Foxp3 enables the expression of transcriptional regulators implicated in memory T cell development.", "Roughly 55% of women with chronic pelvic pain have no underlying pathology.", "Guanine nucleotide exchange factors (GEFs) mediate RhoA activation in response to tensional forces on fibronectin-binding integrins.", "Individuals with Alzheimers who participate in six months of physical activity improve cognitive function for up to 18 months.", "Vaccinating the gastrointestinal tract induces protection of rectal and vaginal mucosa.", "Marmosets have a brain region homologous to Broca's area.", "Having a main partner worsens HIV outcomes.", "Origin gross domestic product(GDP) is positively related to dengue virus (DENV-1) diffusion in air traffic shipments.", "Ultrasound guidance significantly reduces the number of traumatic procedures when attempting needle insertion."], "hard_negatives": ["Exposure to fine particulate air pollution is unrelated to anxiety prevalence.", "Headaches are correlated with cognitive impairment.", "Patients with panic anxiety show decreased CSF levels of hypocretin.", "High levels of CRP lead to a higher risk of exacerbations in chronic obstructive pulmonary disease (COPD).", "Rising temperatures caused by global warming increases risk of dengue fever transmission.", "Cognitive behavioral therapy is an ineffective treatment for insomnia", "Urbanization is an important risk factor related to the transmission of dengue fever.", "Rising temperatures caused by global warming lowers the risk of dengue fever transmission.", "Mice without IFN-\u03b3 or its receptor are highly susceptible to EAM induced with \u03b1-MyHC/CFA.", "Antidepressants increase the severity of migraines."], "hard_negative": "Exposure to fine particulate air pollution is unrelated to anxiety prevalence."}
{"query_id": "401", "query_text": "Expression of MSX2 is induced 3 hours after the addition of BMP4, which is earlier than T and CDX2.", "negative": "Reduced levels of lipolysis leads to higher P38 phosphorylation in adipose tissue.", "negatives": ["Reduced levels of lipolysis leads to higher P38 phosphorylation in adipose tissue.", "CHOP is a general endoplasmic reticulum stress marker.", "Misunderstandings between doctors and patients can lead to non-adherence.", "LRBA prevents CTLA - 4 recycling.", "Consumption of whole fruits increases the risk of type 2 diabetes.", "Cytosolic proteins bind to iron-responsive elements on mRNAs coding for TFRC1.", "Lack of FGF21 in mice leads to atherosclerotic plaque formation.", "JMJD6 catalyzes the hydroxylation of C-terminal lysine and supresses transcriptional activity.", "Lack of FGF21 in mice leads to reduced lifespan.", "siRNA knockdown of A20 accelerates tumor progression in an in vivo murine xenograft model."], "hard_negatives": ["Expression of MSX2 is induced 3 hours after the addition of BMP4, which is earlier than T and CDX2.", "Type 1 Diabetes is associated with subtle perturbations in T reg development.", "PD-1 triggering on monocytes enhances IL-10 production by monocytes.", "IL-10 production by monocytes inhibits CD4 + T cell response.", "p16INK4A degradation is encoded by CDKN2A.", "CD28 initiates tonic signaling in conventional T cells, which causes an exhaustion phenotype and limited efficiency.", "Activation of PPM1D enhances p53 function.", "Upregulation of PD1 causes the downmodulation of Satb1.", "Varying expression levels of EBI2 affect the positioning and migration of B cells.", "Egr2 regulates the homeostasis of B and T cells."], "hard_negative": "Expression of MSX2 is induced 3 hours after the addition of BMP4, which is earlier than T and CDX2."}
{"query_id": "403", "query_text": "Expression of oncolytic virus antigens as peptides makes relapse more likely.", "negative": "Prescribed exercise training improves quality of life.", "negatives": ["Prescribed exercise training improves quality of life.", "Low nucleosome occupancy correlates with high methylation levels across species.", "5'-nucleotidase metabolizes 6MP.", "Diabetes remission occurs less in people treated with conventional therapy than in people treated with laparoscopic adjustable gastric banding surgery.", "Pyridostatin induces double-strand breaks accumulation.", "Mice that lack Interferon-\u03b3 or its receptor are highly susceptible to experimental autoimmune myocarditis.", "Deltex interacts with eIF3. There is no known interaction between Deltex and elF3", "Increased LDL receptors plays a role in the reduction of plasma Lp(a).", "Activator-inhibitor pairs are provided ventrally by Xrl-sizzled.", "Intra-cerebroventricular infusion of amyloid-\u03b2 oligomers reduces expression of fibronectin type-III domain-containing protein 5 mRNA in mice hippocampi."], "hard_negatives": ["Expression of oncolytic virus antigens as peptides makes relapse more likely.", "Expression of oncolytic virus antigens as peptides permits additional protection against relapse.", "Persister cells provide relapse resistance in cancer patients.", "Enhanced early production of inflammatory chemokines damages viral control in the lung.", "90% of patients with melanoma and an objective response to PD-1 blockade will experience a progression in their melanoma.", "Antiretroviral therapy increases rates of tuberculosis across a broad range of CD4 strata.", "Cancer cells can stimulate the accumulation of intra-tumoural myeloid-derived suppressor cells by promoting granulocyte colony stimulating factor production.", "Side effects associated with antidepressants increases risk of stroke.", "Monoclonal antibody targeting of N-cadherin encourages metastasis.", "In melanoma, anti-CTLA-4 treatment reinvigorates exhausted PD-1+Eomes+CD8 T cells."], "hard_negative": "Expression of oncolytic virus antigens as peptides makes relapse more likely."}
{"query_id": "404", "query_text": "Expression of oncolytic virus antigens as peptides permits additional protection against relapse.", "negative": "Long chain polyunsaturated fatty acids supplementation has no significant effects on wheezing or asthma at 3 and 6 years.", "negatives": ["Long chain polyunsaturated fatty acids supplementation has no significant effects on wheezing or asthma at 3 and 6 years.", "5'-nucleotidase metabolizes 6MP.", "4-PBA treatment raises endoplasmic reticulum stress in response to general endoplasmic reticulum stress markers.", "Folate and vitamin B12 levels influence the association between homocysteine and preeclampsia.", "Inside the body, falciparum parasites reproduce asexually.", "Bariatric surgery reduces colorectal cancer.", "Cancer-associated fibroblasts (CAFs) are constituents of tumor microenvironments", "COPI coatmer is involved in lipid homeostasis.", "Bariatric surgery increases rates of postmenopausal breast cancer.", "The amount of publicly available DNA data doubles every 10 months."], "hard_negatives": ["Expression of oncolytic virus antigens as peptides permits additional protection against relapse.", "Expression of oncolytic virus antigens as peptides makes relapse more likely.", "Enhanced early production of inflammatory chemokines damages viral control in the lung.", "Persister cells provide relapse resistance in cancer patients.", "Antiretroviral therapy increases rates of tuberculosis across a broad range of CD4 strata.", "Tuberculosis-induced granulomas express different immune system protein signatures than the surrounding tissue.", "Monoclonal antibody targeting of N-cadherin encourages metastasis.", "Upon viral challenge, influenza-specific memory CD4+ T cells greatly diminish the early production of inflammatory chemokines in the lung.", "Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection increases dissemination of Salmonella Typhimurium from the gut.", "Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection decreases dissemination of Salmonella Typhimurium from the gut."], "hard_negative": "Expression of oncolytic virus antigens as peptides permits additional protection against relapse."}
{"query_id": "406", "query_text": "F4/80+ macrophages regulate mature osteoblast maintenance.", "negative": "Chinese individuals with TT homozygosity in the MTHFR gene are more vulnerable to strokes caused by low levels of folate intake.", "negatives": ["Chinese individuals with TT homozygosity in the MTHFR gene are more vulnerable to strokes caused by low levels of folate intake.", "61% of colorectal cancer patients are diagnosed with regional or distant metastases.", "Flexible molecules experience less steric hindrance in the tumor microenviroment than rigid molecules.", "Pure neural progenitor cell (NPC) populations can only be obtained from cell cultures that undergo passaging, filtration, or other isolation and cell sorting methods.", "Asymptomatic visual impairment screening in elderly populations leads to improved vision.", "Induced hepatic stem cells possess the potential to differentiate into hepatocytic cells.", "Activation of the Rac1 homolog CED-10 kills viable cells in SRGP-1 mutant Caenorhabditis elegans.", "Increased mobility of retrotransposons does not lead to mutation and higher tumorigenesis rates.", "Expression of oncolytic virus antigens as peptides permits additional protection against relapse.", "A high microerythrocyte count protects against severe anemia in homozygous alpha (+)- thalassemia trait subjects."], "hard_negatives": ["F4/80+ macrophages regulate mature osteoblast maintenance.", "Osteocytes have an essential role in G-CSF induced HSPC mobilization.", "TRAP+ osteoclasts regulate mature osteoblast maintenance.", "Osteoparthritis (OA) is characterized by degeneration of articular cartilage, joint edge, and subchondral bone hyperplasia.", "Fibroblast Growth Factor is a ligand which signals through receptor tyrosine kinases.", "Adult tissue-resident macrophages possess a self-renewing capacity.", "MFGE8 regulates fat absorption by binding to av-Beta3 and av-Beta5 integrins.", "Bone marrow cells don't contribute to adult macrophage compartments.", "Klf4 is important for proper myeloid cell differentiation.", "The cytokine receptor which regulates chemotaxis and formation of lymph nodes is involved in production of myeloperoxidase in the left atrium."], "hard_negative": "F4/80+ macrophages regulate mature osteoblast maintenance."}
{"query_id": "407", "query_text": "FACT and other histone chaperone(s) compensate for Histone 2A (H2A)-histone 2B (H2B) dimer eviction during the histone exchange process.", "negative": "NR5A2 is important in reverse cholesterol transport in humans.", "negatives": ["NR5A2 is important in reverse cholesterol transport in humans.", "The relationship between a breast cancer patient's capacity to metabolize tamoxifen and treatment outcome is independent of the patient's genetic make-up.", "ER-localized phosphatase Sac1 processes PI4P through coordination with OSBP and the endosome-localized protein sorting nexin 2.", "There is no association between HNF4A mutations and diabetes risks.", "The origin of the CRF01_1b2k protein occurred between 1923 and 1956.", "ERAP1 SNPs are epistatic to HLA alleles for ankylosing spondylitis.", "Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 inhibit West Nile virus replication in cortical neurons.", "Tuberculosis incidence occurs at higher rates in more sparsely populated areas in the UK.", "The ability of activator E2Fs in preventing cell death is limited to terminally differentiated cells.", "Reduced levels of lipolysis leads to higher P38 phosphorylation in adipose tissue."], "hard_negatives": ["FACT and other histone chaperone(s) compensate for Histone 2A (H2A)-histone 2B (H2B) dimer eviction during the histone exchange process.", "The H2A-H2B eviction defect is compensated for by other histone chaperone(s).", "H4 G94P proteins induce chromatin assembly, which increases free histones.", "Replacement of histone H2A with H2A.Z accelerates gene activation in yeasts by destabilizing +1 nucleosomes.", "H4 G94P proteins induce degradation of free histones via Rad53-dependent mechanisms.", "H4 G94P proteins suppress degradation of free histones via Rad53-dependent mechanisms.", "The G34R/V mutation does not create a hypomethylated phenotype at the H3K36 histone.", "H4 G94P proteins inhibit chromatin assembly, which decreases free histones.", "The G34R/V mutation creates a hypomethylated phenotype at the H3K36 histone.", "Mutations in G-Beta protein GNB1 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway."], "hard_negative": "FACT and other histone chaperone(s) compensate for Histone 2A (H2A)-histone 2B (H2B) dimer eviction during the histone exchange process."}
{"query_id": "413", "query_text": "Female carriers of the Apolipoprotein E4 (APOE4) allele have decreased risk for dementia.", "negative": "Converting apoE4 to apoE3 by gene editing worsens the pathology associated with apoE4 in human iPSCderived neurons.", "negatives": ["Converting apoE4 to apoE3 by gene editing worsens the pathology associated with apoE4 in human iPSCderived neurons.", "Chlamydia trachomatis is most prevalent in the UK among individuals in their 50s and 60s.", "Lice attenuated SIV vaccines induce a stronger antigen-specific T cell response in lymph node cells.", "Replacement of OCT4 and SOX2 genes with GATA3 is not capable of reprogramming human cells.", "Egr3 regulates the homeostasis of B and T cells.", "The PRDM1 gene, when combined with the PRDM14 gene, plays an important role during primordial germ cell specification.", "The C-type lectin receptor (CLEC-2) rearranges the actin cytoskeleton in dendritic cells to promote efficient motility along stromal surfaces.", "Including pharmacists in rounding teams reduces the incidence of adverse drug events (ADEs).", "Pyridostatin stabilizes the G - quadruplex in the telomeric region.", "Forkhead 0 (fox0) transcription factors are involved in apoptosis."], "hard_negatives": ["Female carriers of the Apolipoprotein E4 (APOE4) allele have decreased risk for dementia.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have increased risk for Alzheimer's disease.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have shorter lifetime exposure to estrogen due to a decreased reproductive period.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have longer lifetime exposure to estrogen due to an increased reproductive period.", "Women with a lower birth weight are more likely to develop breast cancer later in life.", "The risk of breast cancer among parous women decreases with placental weight of pregnancies.", "Carriers of HNF4A mutations are at reduced risk for diabetes.", "A mutation in HNF4A leads to an increased risk of developing diabetes by the age of 14 years.", "A mutation in HNF4A leads to an increased risk of diabetes by the age of 14 years.", "In British Men, haplogroup I increases risk of cardiovascular disease by 50%."], "hard_negative": "Female carriers of the Apolipoprotein E4 (APOE4) allele have decreased risk for dementia."}
{"query_id": "414", "query_text": "Female carriers of the Apolipoprotein E4 (APOE4) allele have increased risk for Alzheimer's disease.", "negative": "Charcoal is an effective treatment for acute paraquat poisoning.", "negatives": ["Charcoal is an effective treatment for acute paraquat poisoning.", "Pioneer factor OCT3/4 interacts with major chromatin remodeling factors.", "ALDH1 expression is associated with poorer prognosis for breast cancer primary tumors.", "Microcin J25 inhibits nucleoside triphosphate (NTP) binding.", "ART has no effect on the infectiveness of HIV-positive people.", "Human embryonic stem cells give rise to cell types from all three embryonic germ layers.", "Mice lacking Sirt1 in Sf1-expressing neurons have increased susceptibility to diet-induced obesity and insulin resistance.", "The G34R/V mutation does not create a hypomethylated phenotype at the H3K36 histone.", "CRP is positively correlated with postoperative mortality following Coronary Artery Bypass Graft (CABG) surgery.", "Deltex has no known interactions with eIF3f."], "hard_negatives": ["Female carriers of the Apolipoprotein E4 (APOE4) allele have increased risk for Alzheimer's disease.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have decreased risk for dementia.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have longer lifetime exposure to estrogen due to an increased reproductive period.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have shorter lifetime exposure to estrogen due to a decreased reproductive period.", "Women with a lower birth weight are more likely to develop breast cancer later in life.", "The risk of breast cancer among parous women decreases with placental weight of pregnancies.", "Carriers of HNF4A mutations are at reduced risk for diabetes.", "Physical activity does not improve cognitive function in individuals with Alzheimers.", "A mutation in HNF4A leads to an increased risk of developing diabetes by the age of 14 years.", "Individuals with Alzheimers who participate in six months of physical activity improve cognitive function for up to 18 months."], "hard_negative": "Female carriers of the Apolipoprotein E4 (APOE4) allele have increased risk for Alzheimer's disease."}
{"query_id": "416", "query_text": "Female carriers of the Apolipoprotein E4 (APOE4) allele have longer lifetime exposure to estrogen due to an increased reproductive period.", "negative": "Adult tissue-resident macrophages are seeded before birth.", "negatives": ["Adult tissue-resident macrophages are seeded before birth.", "Physical activity does not improve cognitive function in individuals with Alzheimers.", "Cancer cells can stimulate the accumulation of intra-tumoural myeloid-derived suppressor cells by promoting granulocyte colony stimulating factor production.", "Sudden death can occur in patients with complex ventricular arrhythmias.", "Reducing H3k4me3 methylation induces mouse epiblast stem cells to naive pluripotency efficiently.", "British female students are bullied more than British male students.", "De novo assembly of sequence data has fewer specific contigs than unassembled sequence data.", "Cell autonomous sex determination in somatic cells occurs in Galliformes.", "Sweet taste receptors on the tongue are deactivated by between 1 and 10 mM glucose.", "Pyridostatin prevents double-strand breaks accumulation."], "hard_negatives": ["Female carriers of the Apolipoprotein E4 (APOE4) allele have longer lifetime exposure to estrogen due to an increased reproductive period.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have shorter lifetime exposure to estrogen due to a decreased reproductive period.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have decreased risk for dementia.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have increased risk for Alzheimer's disease.", "The risk of breast cancer among parous women decreases with placental weight of pregnancies.", "Women with a lower birth weight are more likely to develop breast cancer later in life.", "The mean suicide rate in women is lower after miscarriage than live birth.", "Excess gestational weight gain is associated with obesity-related pregnancy outcomes.", "The mean suicide rate in women is higher after miscarriage than live birth.", "Side effects associated with antidepressants do not represent a mortality risk to postmenopausal women."], "hard_negative": "Female carriers of the Apolipoprotein E4 (APOE4) allele have longer lifetime exposure to estrogen due to an increased reproductive period."}
{"query_id": "417", "query_text": "Female carriers of the Apolipoprotein E4 (APOE4) allele have shorter lifetime exposure to estrogen due to a decreased reproductive period.", "negative": "0-dimensional biomaterials lack inductive properties.", "negatives": ["0-dimensional biomaterials lack inductive properties.", "Venules have less significant tunica adventitia than arterioles.", "There is no relation between Erythromycin use and hypertrophic pyloric stenosis.", "MICAL redox enzymes regulate actin dynamics.", "Traditional reviews are biased in their interpretations.", "Individuals with Alzheimers who participate in six months of physical activity improve cognitive function for up to 18 months.", "Active Ly49Q prevents neutrophil polarization.", "The composition of myosin-II isoform switches from the A isoform to the B isoform during hematopoietic differentiation.", "Misunderstandings between doctors and patients can lead to non-adherence.", "Reduced phosphorylation of PP2A suppresses HDAC4 dephosphorylation."], "hard_negatives": ["Female carriers of the Apolipoprotein E4 (APOE4) allele have longer lifetime exposure to estrogen due to an increased reproductive period.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have shorter lifetime exposure to estrogen due to a decreased reproductive period.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have decreased risk for dementia.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have increased risk for Alzheimer's disease.", "The risk of breast cancer among parous women decreases with placental weight of pregnancies.", "Women with a lower birth weight are more likely to develop breast cancer later in life.", "The mean suicide rate in women is lower after miscarriage than live birth.", "The mean suicide rate in women is higher after miscarriage than live birth.", "Excess gestational weight gain is associated with obesity-related pregnancy outcomes.", "Side effects associated with antidepressants do not represent a mortality risk to postmenopausal women."], "hard_negative": "Female carriers of the Apolipoprotein E4 (APOE4) allele have longer lifetime exposure to estrogen due to an increased reproductive period."}
{"query_id": "418", "query_text": "Fibroblast Growth Factor is a ligand which signals through receptor tyrosine kinases.", "negative": "Retinoic acid receptor-related orphan receptor gamma (ROR\u03b3) is a therapeutic target for castration-resistant prostate cancer (CRPC)", "negatives": ["Retinoic acid receptor-related orphan receptor gamma (ROR\u03b3) is a therapeutic target for castration-resistant prostate cancer (CRPC)", "Exercise increases cancer mortality rates among Chinese citizens.", "Myelin sheaths play a role in action potential propagation.", "FoxO3a activation in neuronal death is inhibited by reactive oxygen species (ROS).", "MFGE8 regulates fat absorption by binding to av-Beta3 and av-Beta5 integrins.", "Microcin J25 inhibits nucleoside triphosphate (NTP) binding.", "Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection decreases dissemination of Salmonella Typhimurium from the gut.", "Obesity decreases life quality.", "Pseudogene PTENP1 encodes a transcript that regulates PTEN expression.", "Incidence of 10/66 dementia is higher than the incidence of DSM-IV dementia."], "hard_negatives": ["Fibroblast Growth Factor is a ligand which signals through receptor tyrosine kinases.", "Cancer-associated fibroblasts (CAFs) interact with cancer cells to mediate formation and activation of CAFs.", "Fibroblast growth factor 21 protects against atherosclerosis by modulating adiponectin and SREBP2 levels.", "Cancer-associated fibroblasts (CAFs) have no known interaction with cancer cells in the formation and activation of CAFs.", "Cancer-associated fibroblasts (CAFs) are constituents of tumor microenvironments", "Glioblastoma multiforme (GBM) is characterized by extensive invasion, rapid growth, necrosis, and angiogenesis.", "Addition of BMP4, activin A, CHIR99021, and SU504 to reprogramming fibroblasts generates, expands and maintains cardiovascular progenitor cells (CPCs)", "Cancer cells can stimulate the accumulation of intra-tumoural myeloid-derived suppressor cells by promoting granulocyte colony stimulating factor production.", "The C-type lectin receptor (CLEC-2) rearranges the actin cytoskeleton in dendritic cells to promote efficient motility along stromal surfaces.", "Cancers that initially benefit from epidermal growth factor receptor targeted therapies later become refractory through several mechanisms."], "hard_negative": "Fibroblast Growth Factor is a ligand which signals through receptor tyrosine kinases."}
{"query_id": "420", "query_text": "Fibroblast growth factor 21 protects against atherosclerosis by modulating adiponectin and SREBP2 levels.", "negative": "Citrullinated proteins externalized in neutrophil extracellular traps act indirectly to perpetuate the inflammatory cycle via induction of autoantibodies.", "negatives": ["Citrullinated proteins externalized in neutrophil extracellular traps act indirectly to perpetuate the inflammatory cycle via induction of autoantibodies.", "Deletion of ATM and Rad3 related protein is not predictive of acute tissue loss.", "Osteocytes have an essential role in G-CSF induced HSPC mobilization.", "Increase of p62 in prostate tumor stroma results in defective autophagy.", "Vaccinating the gastrointestinal tract induces protection of rectal and vaginal mucosa.", "Expression of oncolytic virus antigens as peptides makes relapse more likely.", "L3MBTL2 binds to H2AK119Ub marked chromatin to form a PRC1 complex.", "Klf4 is important for proper myeloid cell differentiation.", "There is no known interaction between Pioneer factor OCT3/4 and major chromatin remodeling factors.", "In the UK, drowning affects boys and girls equally."], "hard_negatives": ["Fibroblast growth factor 21 protects against atherosclerosis by modulating adiponectin and SREBP2 levels.", "Fibroblast Growth Factor is a ligand which signals through receptor tyrosine kinases.", "Lack of FGF21 in mice slows the rate of atherosclerotic plaque formation.", "Lack of FGF21 in mice leads to atherosclerotic plaque formation.", "Cancer-associated fibroblasts (CAFs) interact with cancer cells to mediate formation and activation of CAFs.", "Cancer-associated fibroblasts (CAFs) have no known interaction with cancer cells in the formation and activation of CAFs.", "Lack of FGF21 in mice leads to reduced lifespan.", "Binding of p53 to enhancer regions (p53BERs) regulates the activity of p53 transcription and cell cycle arrest through the production of p53-dependent eRNAs.", "Lack of FGF21 in mice increases life expectancy.", "Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes fibrosis."], "hard_negative": "Fibroblast growth factor 21 protects against atherosclerosis by modulating adiponectin and SREBP2 levels."}
{"query_id": "422", "query_text": "Flexible molecules experience less steric hindrance in the tumor microenviroment than rigid molecules.", "negative": "Cancer-associated fibroblasts (CAFs) interact with cancer cells to mediate formation and activation of CAFs.", "negatives": ["Cancer-associated fibroblasts (CAFs) interact with cancer cells to mediate formation and activation of CAFs.", "EGR2 is important to myelination of the peripheral nervous system.", "Allogeneic mechanical circulatory support is not as effective as autologous mechanical circulatory support for treating acute myocardial infarction.", "Enhanced early production of inflammatory chemokines damages viral control in the lung.", "The minor G allele of FOXO3 up-regulates IL-10.", "Monoclonal antibody targeting of N-cadherin inhibits growth.", "Clathrin stabilizes the spindle fiber apparatus during mitosis.", "Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection decreases dissemination of Salmonella Typhimurium from the gut.", "The proliferative capacity of progenitors is regulated cell-autonomously.", "Patients with common epithelial cancers  are more likely to have an emergency event as their first hospital admission if they live in resource-deprived areas."], "hard_negatives": ["Flexible molecules experience less steric hindrance in the tumor microenviroment than rigid molecules.", "Cancer-associated fibroblasts (CAFs) are constituents of tumor microenvironments", "0-dimensional biomaterials lack inductive properties.", "Lamins have no effect on nuclear membrane structure maintenance.", "Cancer-associated fibroblasts (CAFs) interact with cancer cells to mediate formation and activation of CAFs.", "Cancer-associated fibroblasts (CAFs) have no known interaction with cancer cells in the formation and activation of CAFs.", "Myelin sheaths are lipid-rich cellular structures.", "The microtubule-dependent delivery and secretion of matrix metalloproteases (MMPs) is partially responsible for the disassembly of adhesion sites.", "Inhibiting focal adhesion formation enables cells to convert mechanical strain into eventual scarring.", "Lamins are associated with nuclear membrane structure maintenance."], "hard_negative": "Flexible molecules experience less steric hindrance in the tumor microenviroment than rigid molecules."}
{"query_id": "423", "query_text": "Folate and vitamin B12 levels influence the association between homocysteine and preeclampsia.", "negative": "Rapamycin increases the concentration of triacylglycerols in fruit flies.", "negatives": ["Rapamycin increases the concentration of triacylglycerols in fruit flies.", "Tuberculosis incidence occurs at higher rates in more sparsely populated areas in the UK.", "HbA1c consistently overestimates glycemic control in black individuals with Sickle cell trait (SCT).", "Patients in stable partnerships have a slower progression from HIV to AIDS.", "Increased LDL receptors plays a role in the reduction of plasma Lp(a).", "Upregulation of PD1 causes the upregulation of Satb1.", "H4 G94P proteins induce chromatin assembly, which increases free histones.", "Consumption of whole fruits increases the risk of type 2 diabetes.", "Neutrophils produce IL-1\u03b2 in response to large particles.", "Reduction of purity of cytoplasmic membranes isolated from overexpressors is indicated by stronger spots for OmpA in 2D BN-PAGE gels."], "hard_negatives": ["Folate and vitamin B12 levels influence the association between homocysteine and preeclampsia.", "A deficiency of folate increases blood levels of homocysteine.", "A deficiency of vitamin B12 decreases blood levels of homocysteine.", "Intake of folic acid (FA) and vitamin B6 (VB6) increases levels of homocysteine.", "Intake of folic acid (FA) and vitamin B6 (VB6) reduces levels of homocysteine.", "A deficiency of vitamin B6 decreases blood levels of homocysteine.", "Vitamin D is an important factor in the relationship between calcium and parathyroid hormone.", "Vitamin D deficiency effects birth weight.", "LDL cholesterol has a causal role in the development of cardiovascular disease.", "Mutations in G-Beta protein GNB1 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway."], "hard_negative": "Folate and vitamin B12 levels influence the association between homocysteine and preeclampsia."}
{"query_id": "425", "query_text": "For every 1,000 children with cerebral palsy, more than 300 of them are premature or underweight at birth.", "negative": "The peak incidence of fractures occurs during pubertal growth spurt in early adolescents.", "negatives": ["The peak incidence of fractures occurs during pubertal growth spurt in early adolescents.", "The density of cytokine receptor bearing cells affects the distance over which cytokines act.", "GATA3 regulates self-renewal capacity in bone marrow hematopoietic stem cells.", "Including pharmacists in rounding teams does not alter the incidence of adverse drug events (ADEs).", "Healthy volunteers exhibit rapid and transient increase of cellular ATP after being bolus-injected with fructose.", "Therapeutics receiving accelerated approval encounter a lower frequency of post-marketing safety events", "Prescribed exercise training improves quality of life.", "Pseudogene PTENP1 encodes a transcript that regulates PTEN expression.", "Diabetes remission occurs less in people treated with conventional therapy than in people treated with laparoscopic adjustable gastric banding surgery.", "Vaccinating the gastrointestinal tract induces protection of rectal and vaginal mucosa."], "hard_negatives": ["For every 1,000 children with cerebral palsy, more than 300 of them are premature or underweight at birth.", "53% of perinatal mortality is due to low birth weight.", "10% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.", "90% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.", "Nonhypertensive people who are 55 years old have a 90% chance of developing hypertension during their lifetime.", "There was an estimated 30 million cases of pneumonia in young children worldwide in 2010.", "Women with a lower birth weight are more likely to develop breast cancer later in life.", "A mutation in HNF4A leads to an increased risk of developing diabetes by the age of 14 years.", "The proportion of people with visual difficulty is two times higher in low-income countries than in high-income countries.", "The peak incidence of fractures occurs in toddlers."], "hard_negative": "For every 1,000 children with cerebral palsy, more than 300 of them are premature or underweight at birth."}
{"query_id": "426", "query_text": "Forkhead 0 (fox0) transcription factors are involved in apoptosis.", "negative": "The RANK-RANK-Ligand (RANKL) pathway is involved in the development of Aire-expressing medullary thymic epithelial cells (mTECs).", "negatives": ["The RANK-RANK-Ligand (RANKL) pathway is involved in the development of Aire-expressing medullary thymic epithelial cells (mTECs).", "Comparative transcriptome analysis identified new platelet proteins with structural features suggesting a role in platelet function.", "Decreased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm.", "Cancer-associated fibroblasts (CAFs) are constituents of tumor microenvironments", "Approximately 250,000 people are infected with human T-cell lymphotropic virus type 1 in the United Kingdom.", "1-1% of colorectal cancer patients are diagnosed with regional or distant metastases.", "\u03b21/Ketel is able to bind microtubules.", "Stiff substrates encourage mesodermal differentiation by degrading beta-catenin in an integrin-dependent manner.", "Chlamydia trachomatis is most prevalent in the UK among sexually-experienced individuals aged 16 to 24.", "Lmna knock-in models are appropriate for testing therapeutic approaches against Hutchinson-Gilford progeria syndrome (HGPS)."], "hard_negatives": ["Forkhead 0 (fox0) transcription factors are involved in apoptosis.", "Forkhead 0 (fox0) transcription factors are involved in cellular differentiation.", "Foxp3 enables the expression of transcriptional regulators implicated in memory T cell development.", "Foxk2 regulates autophagy genes in muscle cells and fibroblast cells.", "Foxp3 represses the expression of transcriptional regulators implicated in memory T cell development.", "FoxO3a activation in neuronal death is inhibited by reactive oxygen species (ROS).", "Mitochondria play a major role in apoptosis.", "The minor G allele of FOXO3 downregulates pro-inflammatory cytokines.", "The gene daf-16, which encodes forkhead Box O (FOXO), is required for all phenotypes associated with reduced insulin/insulin-like growth factor (Igf) signaling.", "The minor G allele of FOXO3 up-regulates IL-10."], "hard_negative": "Forkhead 0 (fox0) transcription factors are involved in apoptosis."}
{"query_id": "428", "query_text": "Forkhead 0 (fox0) transcription factors are involved in cellular differentiation.", "negative": "The first MBT repeat of the four malignant brain tumor (4MBT) domain of Drosophila's Sfmbt and of the orthologous mammalian L3MBTL2 is required for the interaction with the spacer region of Drosophila's Pleiohomeotic (Pho) or its human ortholog YY1.", "negatives": ["The first MBT repeat of the four malignant brain tumor (4MBT) domain of Drosophila's Sfmbt and of the orthologous mammalian L3MBTL2 is required for the interaction with the spacer region of Drosophila's Pleiohomeotic (Pho) or its human ortholog YY1.", "The density of cytokine receptor bearing cells has no effect on the distance over which cytokines act.", "Taxation of sugar-sweetened beverages reduced the incidence rate of type II diabetes in India.", "The number of unfertilized oocytes in mated hermaphrodites increases with age.", "Low expression of miR7a does not repress target genes or exert a biological function in testis.", "Input from  mental and physical health care professionals is not effective at decreasing homelessness.", "aPKCz causes tumour suppression by affecting glutamine metabolism.", "Activator-inhibitor pairs are provided ventrally by Xrl-sizzled.", "Notch signaling occurs between tumor cells and stromal cells.", "90% of patients with melanoma and an objective response to PD-1 blockade will experience a progression in their melanoma."], "hard_negatives": ["Forkhead 0 (fox0) transcription factors are involved in cellular differentiation.", "Forkhead 0 (fox0) transcription factors are involved in apoptosis.", "Foxk2 regulates autophagy genes in muscle cells and fibroblast cells.", "Foxp3 enables the expression of transcriptional regulators implicated in memory T cell development.", "Foxp3 represses the expression of transcriptional regulators implicated in memory T cell development.", "Binding of p53 to enhancer regions (p53BERs) regulates the activity of p53 transcription and cell cycle arrest through the production of p53-dependent eRNAs.", "The gene daf-16, which encodes forkhead Box O (FOXO), is required for all phenotypes associated with reduced insulin/insulin-like growth factor (Igf) signaling.", "Distant CREs are important for transcriptional regulation.", "KRT17 modulates the expression of the transcriptional regulator AIRE in diseased epithelia.", "FoxO3a activation in neuronal death is inhibited by reactive oxygen species (ROS)."], "hard_negative": "Forkhead 0 (fox0) transcription factors are involved in cellular differentiation."}
{"query_id": "429", "query_text": "Formation of N-terminal pyroglutamate by glutamine cyclase (GC) competes with NTAQ1 for Nt-Gln substrates.", "negative": "Higher plasma levels of I-carnitine, when associated with trimethylamine N-oxide, are positively correlated with cardiovascular events in humans.", "negatives": ["Higher plasma levels of I-carnitine, when associated with trimethylamine N-oxide, are positively correlated with cardiovascular events in humans.", "Concentrations of SNV and CNV in stem-cell regulatory elements and binding sites of transcription factors in iPSC-lines are distinct from their founding cells.", "The number of unfertilized oocytes in mated hermaphrodites increases with age.", "Autophagy deficiency in the liver increases vulnerability to insulin resistance.", "Ribosome-inactivating protein-2 (RIP-2) interacts with the p75 NTR death domain", "Reducing H3k4me3 methylation induces mouse epiblast stem cells to naive pluripotency efficiently.", "Intra-cerebroventricular infusion of amyloid-\u03b2 oligomers reduces expression of fibronectin type-III domain-containing protein 5 mRNA in mice hippocampi.", "Oxidative DNA damage inhibits STING signalling.", "Roughly 55% of women with chronic pelvic pain have no underlying pathology.", "Removal of H3K9me3 by ectopic expression of other H3K9 demethylases improves reprogramming efficiency in SCNT experiments."], "hard_negatives": ["Formation of N-terminal pyroglutamate by glutamine cyclase (GC) competes with NTAQ1 for Nt-Gln substrates.", "Guanine nucleotide dissociation inhibitor (Rho-GDI) interacts with the p75 NTR death domain", "Replacement of histone H2A with H2A.Z accelerates gene activation in yeasts by destabilizing +1 nucleosomes.", "Ribosome-inactivating protein-2 (RIP-2) interacts with the p75 NTR death domain", "p75 NTR - associated cell death executor (NADE) interacts with the p75 NTR death domain", "The deamination of cytidine to uridine on the minus strand of viral DNA can inactivate the viral genome by inducing G-to-A mutations.", "Pyridostatin stabilizes the G - quadruplex in the telomeric region.", "JMJD6 slows the hydroxylation of C-terminal lysine", "Kir7.1 modulates channel activity by the G protein-coupled melanocortin-4 receptor (MC4R) in the paraventricular nucleus of the hypothalamus.", "Emodin forms hydrogen bonds with residues involved in PGAM1 substrate binding."], "hard_negative": "Formation of N-terminal pyroglutamate by glutamine cyclase (GC) competes with NTAQ1 for Nt-Gln substrates."}
{"query_id": "430", "query_text": "FoxO3a activation in neuronal death is inhibited by reactive oxygen species (ROS).", "negative": "Hematopoietic Stem Cell purification reaches purity rates above 90%.", "negatives": ["Hematopoietic Stem Cell purification reaches purity rates above 90%.", "Adult tissue-resident macrophages stem from the embryonal yolk sac and fetal liver.", "Polymeal nutrition increases cardiovascular mortality.", "Guanine nucleotide exchange factors (GEFs) mediate RhoA activation in response to tensional forces on fibronectin-binding integrins.", "Integrating classroom-based collaborative learning with Web-based collaborative learning offers the best class performance.", "Mitochondria play a trivial role in calcium homeostasis.", "Nigerian physicians constitue the largest component of sub-Saharan Africa-trained physicians in the United States.", "Sequence conservation in gene regulatory regions between species is a high-accuracy predictor of conserved functionality.", "Recognition of start codons depends on the translation initiation factor IF3.", "Replacement of histone H2A with H2A.Z accelerates gene activation in yeasts by destabilizing +1 nucleosomes."], "hard_negatives": ["FoxO3a activation in neuronal death is inhibited by reactive oxygen species (ROS).", "The minor G allele of FOXO3 up-regulates IL-10.", "The minor G allele of FOXO3 downregulates pro-inflammatory cytokines.", "Foxk2 regulates autophagy genes in muscle cells and fibroblast cells.", "The gene daf-16, which encodes forkhead Box O (FOXO), is required for all phenotypes associated with reduced insulin/insulin-like growth factor (Igf) signaling.", "Foxp3 represses the expression of transcriptional regulators implicated in memory T cell development.", "Foxp3 enables the expression of transcriptional regulators implicated in memory T cell development.", "Activated Cdk5 regulates DNA damage-induced neuronal death.", "The minor G allele of FOXO3 is related to less severe symptoms of Crohn's Disease.", "Forkhead 0 (fox0) transcription factors are involved in apoptosis."], "hard_negative": "FoxO3a activation in neuronal death is inhibited by reactive oxygen species (ROS)."}
{"query_id": "432", "query_text": "Foxk2 regulates autophagy genes in muscle cells and fibroblast cells.", "negative": "Sn is present on mature DCs during inflammation in vivo.", "negatives": ["Sn is present on mature DCs during inflammation in vivo.", "CCL19 is predominantly present within dLNs.", "TNFAIP3 is a glioblastoma tumor enhancer.", "LRBA prevents CTLA - 4 recycling.", "Notch signaling occurs between tumor cells and stromal cells.", "Rising temperatures caused by global warming increases risk of dengue fever transmission.", "Bariatric surgery reduces colorectal cancer.", "Cyclin A2 destruction is necessary to switch from unstable to stable kt-mt attachments in mitosis.", "CDK6 shows improved binding to loss-of-function variants of p18 INK4C.", "Metastatic colorectal cancer treated with a single agent fluoropyrimidines resulted in similar efficacy and better quality of life when compared with oxaliplatin-based chemotherapy in elderly patients."], "hard_negatives": ["Foxk2 regulates autophagy genes in muscle cells and fibroblast cells.", "Foxp3 represses the expression of transcriptional regulators implicated in memory T cell development.", "Foxp3 enables the expression of transcriptional regulators implicated in memory T cell development.", "FoxO3a activation in neuronal death is inhibited by reactive oxygen species (ROS).", "The minor G allele of FOXO3 up-regulates IL-10.", "The minor G allele of FOXO3 downregulates pro-inflammatory cytokines.", "Reduced responsiveness to interleukin-2 in regulatory T cells is associated with autoimmune diseases such as Type 1 Diabetes.", "Forkhead 0 (fox0) transcription factors are involved in cellular differentiation.", "Forkhead 0 (fox0) transcription factors are involved in apoptosis.", "Egr2 regulates the homeostasis of B and T cells."], "hard_negative": "Foxk2 regulates autophagy genes in muscle cells and fibroblast cells."}
{"query_id": "434", "query_text": "Foxp3 enables the expression of transcriptional regulators implicated in memory T cell development.", "negative": "Glycan adaptation involves insertion-deletion events.", "negatives": ["Glycan adaptation involves insertion-deletion events.", "BRCA 1 mutation carriers' risk of breast and ovarian cancer depends on where the mutation is located.", "Forkhead 0 (fox0) transcription factors are involved in apoptosis.", "Thiopurine active metabolites can be catabolized through dephosphorylation of thioguanine nucleotides.", "Distant CREs are less conserved among species.", "Stiff substrates inhibit mesodermal differentiation by degrading beta-catenin in an integrin-dependent manner.", "The TRaF1/C5 rs10818488 allele polymorphism regulates the neighboring C5 gene.", "Combination nicotine replacement therapies with varenicline or bupropion are more effective after 12 weeks of reatment compared to varenicline monotherapy.", "Active caspase-11 participate in regulating phagosome-lysosome fusion.", "A diminished ovarian reserve does not solely indicate infertility in an a priori non-infertile population."], "hard_negatives": ["Foxp3 enables the expression of transcriptional regulators implicated in memory T cell development.", "Foxp3 represses the expression of transcriptional regulators implicated in memory T cell development.", "Foxk2 regulates autophagy genes in muscle cells and fibroblast cells.", "ITAM phosphorylation allows for the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).", "The minor G allele of FOXO3 up-regulates IL-10.", "CD28 signals regulate trafficking of murine auto-reactive T cells into target tissues.", "FoxO3a activation in neuronal death is inhibited by reactive oxygen species (ROS).", "GATA3 regulates cell cycle progression in bone marrow hematopoietic stem cells.", "TNFAIP3 is a glioblastoma tumor suppressor.", "The minor G allele of FOXO3 downregulates pro-inflammatory cytokines."], "hard_negative": "Foxp3 enables the expression of transcriptional regulators implicated in memory T cell development."}
{"query_id": "435", "query_text": "Foxp3 represses the expression of transcriptional regulators implicated in memory T cell development.", "negative": "Aged patients are less susceptible to ischaemia/reperfusion injury.", "negatives": ["Aged patients are less susceptible to ischaemia/reperfusion injury.", "Sepsis related mortality has remained stable between 2009-2014.", "Improvements in OER catalysts show stable activity over several hundred hours.", "A diminished ovarian reserve does not solely indicate infertility in an a priori non-infertile population.", "The ability of activator E2Fs in preventing cell death is limited to terminally differentiated cells.", "Recognition of start codons depends on the translation initiation factor IF3.", "Inhibiting focal adhesion formation enables cells to convert mechanical strain into eventual scarring.", "Mice defective for deoxyribonucleic acid (DNA) polymerase I (polI) fail to reveal increased sensitivity to ionizing radiation (IR).", "Increase of p62 in prostate tumor stroma results in defective autophagy.", "A T helper 2 cell (Th2) environment impedes disease development in patients with systemic lupus erythematosus (SLE)."], "hard_negatives": ["Foxp3 represses the expression of transcriptional regulators implicated in memory T cell development.", "Foxp3 enables the expression of transcriptional regulators implicated in memory T cell development.", "Foxk2 regulates autophagy genes in muscle cells and fibroblast cells.", "The minor G allele of FOXO3 up-regulates IL-10.", "FoxO3a activation in neuronal death is inhibited by reactive oxygen species (ROS).", "CD28 signals regulate trafficking of murine auto-reactive T cells into target tissues.", "ITAM phosphorylation allows for the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).", "The minor G allele of FOXO3 downregulates pro-inflammatory cytokines.", "Reduced responsiveness to interleukin-2 in regulatory T cells is associated with autoimmune diseases such as Type 1 Diabetes.", "TNFAIP3 is a glioblastoma tumor suppressor."], "hard_negative": "Foxp3 represses the expression of transcriptional regulators implicated in memory T cell development."}
{"query_id": "441", "query_text": "G-CSF increases the expansion and infiltration of MDSCs into tumors.", "negative": "IL-10 production by monocytes inhibits CD4 + T cell response.", "negatives": ["IL-10 production by monocytes inhibits CD4 + T cell response.", "Early patent ductus ateriosus (PDA) screening decreases in-hospital mortality.", "The one-child policy has created a hospitable environment for female infants.", "Microcin J25 inhibits nucleoside triphosphate (NTP) binding.", "Intra-cerebroventricular infusion of amyloid-\u03b2 oligomers reduces expression of fibronectin type-III domain-containing protein 5 mRNA in mice hippocampi.", "The morphology change from large white adipocytes to small brown adipocytes is a sign of decreased energy expenditure potential in white adipose tissue.", "Distant CREs are important for transcriptional regulation.", "Glioblastoma multiforme (GBM) is characterized by extensive invasion, rapid growth, necrosis, and angiogenesis.", "Ectopic expression of Sall4, Nanog, Esrrb, and Lin28 generates induced pluripotent stem cells from mouse embryonic fibroblasts more efficiently than other factor combinations.", "Genomic sequences involved in alternative splicing responsible for Hutchinson-Gilford progeria syndrome (HGPS) are abundant in the ''progerinonly'' allele of Lmna knock-in models."], "hard_negatives": ["G-CSF increases the expansion and infiltration of MDSCs into tumors.", "Deleting Raptor increases G-CSF levels.", "Cancer-associated fibroblasts (CAFs) interact with cancer cells to mediate formation and activation of CAFs.", "Cancer-associated fibroblasts (CAFs) have no known interaction with cancer cells in the formation and activation of CAFs.", "Increased vessel density along with a reduction in fibrosis improves the efficacy of chemotherapy treatments.", "Osteocytes have an essential role in G-CSF induced HSPC mobilization.", "Cancer cells can stimulate the accumulation of intra-tumoural myeloid-derived suppressor cells by promoting granulocyte colony stimulating factor production.", "Glioblastoma multiforme (GBM) is characterized by extensive invasion, rapid growth, necrosis, and angiogenesis.", "LRBA prevents CTLA - 4 recycling.", "LRBA promotes CTLA - 4 recycling."], "hard_negative": "G-CSF increases the expansion and infiltration of MDSCs into tumors."}
{"query_id": "444", "query_text": "GATA3 regulates cell cycle progression in bone marrow hematopoietic stem cells.", "negative": "Ca2+ cycling controls whole-body energy homeostasis in beige fat.", "negatives": ["Ca2+ cycling controls whole-body energy homeostasis in beige fat.", "Sympathetic nerve activity is reduced throughout normal pregnancy.", "Expression of MSX2 is induced 3 hours after the addition of BMP4, which is earlier than T and CDX2.", "Mitochondria play a major role in energy production.", "LRBA prevents CTLA - 4 recycling.", "Suboptimal nutrition is a leading cause of premature death", "Gastric infection with Helicobacter pylori decreases risk of gastric cancer in humans.", "In melanoma, anti-CTLA-4 treatment reinvigorates exhausted PD-1+Eomes+CD8 T cells.", "In transgenic mice harboring green florescent protein under the control of the Sox2 promoter, more than 50 percent of the cells with green florescent colocalize with cell proliferation markers.", "The PDPN gene deactivates the C-type lectin receptor (CLEC-2)."], "hard_negatives": ["GATA3 regulates cell cycle progression in bone marrow hematopoietic stem cells.", "GATA3 regulates self-renewal capacity in bone marrow hematopoietic stem cells.", "Egr3 regulates the homeostasis of B and T cells.", "TNFAIP3 is a glioblastoma tumor suppressor.", "Foxp3 enables the expression of transcriptional regulators implicated in memory T cell development.", "Foxp3 represses the expression of transcriptional regulators implicated in memory T cell development.", "TNFAIP3 is a glioblastoma tumor enhancer.", "TNFAIP3 is a tumor enhancer in glioblastoma.", "The minor G allele of FOXO3 up-regulates IL-10.", "Foxk2 regulates autophagy genes in muscle cells and fibroblast cells."], "hard_negative": "GATA3 regulates cell cycle progression in bone marrow hematopoietic stem cells."}
{"query_id": "445", "query_text": "GATA3 regulates self-renewal capacity in bone marrow hematopoietic stem cells.", "negative": "Pediatric SCD patients with vaso-occlusive crisis show increased morphine use after breathing 80 ppm iNO for 4 hours.", "negatives": ["Pediatric SCD patients with vaso-occlusive crisis show increased morphine use after breathing 80 ppm iNO for 4 hours.", "A diminished ovarian reserve is a very strong indicator of infertility, even in an a priori non-infertile population.", "The recruitment of Wdr5 to its target loci depends on Kat8.", "GATA3 regulates self-renewal capacity in bone marrow hematopoietic stem cells.", "Inhibiting glucose-6-phospate dehydrogenase improves lipogenesis by deactivating LKB1-AMPK signaling.", "ALDH1 expression is associated with poorer prognosis for breast cancer primary tumors.", "Intra-cerebroventricular infusion of amyloid-\u03b2 oligomers increases expression of fibronectin type-III domain-containing protein 5 mRNA in mice hippocampi.", "Patients with common epithelial cancers  are more likely to have an emergency event as their first hospital admission if they live in resource-deprived areas.", "Approximately 250,000 people are infected with human T-cell lymphotropic virus type 1 in the United Kingdom.", "Glial calcium waves influence seizures."], "hard_negatives": ["GATA3 regulates self-renewal capacity in bone marrow hematopoietic stem cells.", "GATA3 regulates cell cycle progression in bone marrow hematopoietic stem cells.", "Egr3 regulates the homeostasis of B and T cells.", "TNFAIP3 is a glioblastoma tumor suppressor.", "Foxp3 enables the expression of transcriptional regulators implicated in memory T cell development.", "Foxp3 represses the expression of transcriptional regulators implicated in memory T cell development.", "TNFAIP3 is a glioblastoma tumor enhancer.", "TNFAIP3 is a tumor enhancer in glioblastoma.", "The minor G allele of FOXO3 up-regulates IL-10.", "IL-10 production by monocytes inhibits CD4 + T cell response."], "hard_negative": "GATA3 regulates self-renewal capacity in bone marrow hematopoietic stem cells."}
{"query_id": "447", "query_text": "Gastric infection with Helicobacter pylori decreases risk of gastric cancer in humans.", "negative": "Intake of folic acid (FA) and vitamin B6 (VB6) reduces levels of homocysteine.", "negatives": ["Intake of folic acid (FA) and vitamin B6 (VB6) reduces levels of homocysteine.", "Primary cervical cytology screening with HPV detection has higher longitudinal sensitivity to detect severe cervical intraepithelial neoplasia than conventional cytology.", "Amitriptyline is an effective treatment for chronic tension-type headaches.", "TMEM27 is a marker for beta cells.", "Anthrax spores remain deadly until affected areas are decontaminated.", "Human embryonic stem cells give rise to cell types from the outer embryonic germ layer, but not the other two layers.", "The origin of the CRF01_1b2k protein occurred between 1923 and 1956.", "Rhythmic expression of Cry1 translates directly into a circadian regulation of cAMP signaling in gluconeogenesis.", "HAND2 methylation is a key step in early endometrial carcinogenesis.", "Antimicrobial agents are more effective due to the pressure of antimicrobial usage."], "hard_negatives": ["Gastric infection with Helicobacter pylori increases risk of gastric cancer in humans.", "Gastric infection with Helicobacter pylori decreases risk of gastric cancer in humans.", "H.pylori-mediated gastric cancer occurs due to the accumulation of mutations in host epithelial cells.", "Ten percent (10%) of kidney cancers in the UK are attributable to excess weight.", "The latent infection of myeloid cells with human cytomegalovirus induces a number of changes in gene expression.", "Gastric lavage is an effective treatment for acute paraquat poisoning.", "Pioglitazone use is significantly associated with an increased risk of pancreatic cancer.", "In breast cancer, the loss of myoepithelial cells slows the transition of ductal carcinoma in situ to invasive carcinoma.", "In breast cancer, the loss of myoepithelial cells promotes the transition of ductal carcinoma in situ to invasive carcinoma.", "High levels of CRP lead to a higher risk of exacerbations in chronic obstructive pulmonary disease (COPD)."], "hard_negative": "Gastric infection with Helicobacter pylori increases risk of gastric cancer in humans."}
{"query_id": "448", "query_text": "Gastric infection with Helicobacter pylori increases risk of gastric cancer in humans.", "negative": "Differentiated E2f-1, -2, -3 TKO cells in the intestine do not exhibit apoptosis.", "negatives": ["Differentiated E2f-1, -2, -3 TKO cells in the intestine do not exhibit apoptosis.", "NR5A2 does not play a role in development of endometrial tissues.", "The risk of breast cancer among parous women decreases with placental weight of pregnancies.", "One in two surgical randomized controlled trials are discontinued early.", "Formation of N-terminal pyroglutamate by glutamine cyclase (GC) competes with NTAQ1 for Nt-Gln substrates.", "The C-type lectin receptor (CLEC-2) rearranges the actin cytoskeleton in dendritic cells to promote efficient motility along stromal surfaces.", "Participants who quit smoking reduce lung cancer risk by approximately 50%.", "Adult tissue-resident macrophages stem from the embryonal yolk sac and fetal liver.", "Converting apoE4 to apoE3 by gene editing worsens the pathology associated with apoE4 in human iPSCderived neurons.", "The removal of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells."], "hard_negatives": ["Gastric infection with Helicobacter pylori increases risk of gastric cancer in humans.", "Gastric infection with Helicobacter pylori decreases risk of gastric cancer in humans.", "H.pylori-mediated gastric cancer occurs due to the accumulation of mutations in host epithelial cells.", "Gastric lavage is an effective treatment for acute paraquat poisoning.", "The latent infection of myeloid cells with human cytomegalovirus induces a number of changes in gene expression.", "Ten percent (10%) of kidney cancers in the UK are attributable to excess weight.", "Pioglitazone use is significantly associated with an increased risk of pancreatic cancer.", "In breast cancer, the loss of myoepithelial cells slows the transition of ductal carcinoma in situ to invasive carcinoma.", "In breast cancer, the loss of myoepithelial cells promotes the transition of ductal carcinoma in situ to invasive carcinoma.", "High levels of CRP lead to a higher risk of exacerbations in chronic obstructive pulmonary disease (COPD)."], "hard_negative": "Gastric infection with Helicobacter pylori increases risk of gastric cancer in humans."}
{"query_id": "449", "query_text": "Gastric lavage is an effective treatment for acute paraquat poisoning.", "negative": "Increased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm.", "negatives": ["Increased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm.", "LDL cholesterol has a causal role in the development of cardiovascular disease.", "General exercise therapy is more effective than rotator cuff exercises in reducing pain and improving function of the shoulder.", "A country's Vaccine Alliance (GAVI) eligibility is not indictivate of accelerated adoption of the Hub vaccine.", "Chenodeoxycholic acid treatment decreases brown adipose tissue activity.", "BRCA 1 mutation carriers' risk of breast and ovarian cancer depends on where the mutation is located.", "Primary pro-inflammatory cytokines suppress secondary pro- and anti-inflammatory mediators.", "Specialized functional cell types can be derived from human pluripotent stem cells.", "HbA1c consistently overestimates glycemic control in black individuals with Sickle cell trait (SCT).", "HAND2 methylation is a key step in early endometrial carcinogenesis."], "hard_negatives": ["Gastric lavage is an effective treatment for acute paraquat poisoning.", "Charcoal is an effective treatment for acute paraquat poisoning.", "Charcoal shows no benefit for acute paraquat poisoning.", "Gastric infection with Helicobacter pylori increases risk of gastric cancer in humans.", "Gastric infection with Helicobacter pylori decreases risk of gastric cancer in humans.", "High levels of CRP lead to a higher risk of exacerbations in chronic obstructive pulmonary disease (COPD).", "The most prevalent adverse events to Semaglutide are gastrointestinal.", "Pioglitazone use is significantly associated with an increased risk of pancreatic cancer.", "Noninvasive positive pressure ventilation is not predictive of acute respiratory failure after solid organ transplantation.", "Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission."], "hard_negative": "Gastric lavage is an effective treatment for acute paraquat poisoning."}
{"query_id": "453", "query_text": "General exercise therapy is more effective than rotator cuff exercises in reducing pain and improving function of the shoulder.", "negative": "1 in 5 million in UK have abnormal PrP positivity.", "negatives": ["1 in 5 million in UK have abnormal PrP positivity.", "Measuring routine outcomes is more beneficial to clinical practice than assessing treatment adherence.", "Insulin decreases risk of severe kidney failure.", "Genes regulated by Esrrb transcription factor are sensitive to Mbd3 function.", "The World Health Organization's (WHO) data collection process is biased downward by unequal selection of larger outbreaks.", "Trans-acting factors, such as lncRNAs, influence mRNA translation.", "Eliminating the last sporadic cases of malaria requires considerable funding.", "Insulin decreases risk of severe kidney failure.", "JMJD6 slows the hydroxylation of C-terminal lysine", "Noninvasive positive pressure ventilation is not predictive of acute respiratory failure after solid organ transplantation."], "hard_negatives": ["General exercise therapy is more effective than rotator cuff exercises in reducing pain and improving function of the shoulder.", "Rotator cuff exercises are more effective than general exercise therapy in reducing pain and improving function of the shoulder.", "General exercise therapy is more effective than scapular stabilizer exercises in reducing pain and improving function of the shoulder.", "Scapular stabilizer exercises are more effective than general exercise therapy in reducing pain and improving function of the shoulder.", "Surgical treatment is not superior to non-surgical in treating adults with displaced fractures of the proximal humerus.", "Roughly 55% of women with chronic pelvic pain have no underlying pathology.", "There is a positive correlation between hip fractures and statin use.", "Amitriptyline is an effective treatment for chronic tension-type headaches.", "Diabetes remission occurs less in people treated with conventional therapy than in people treated with laparoscopic adjustable gastric banding surgery.", "Diabetes remission occurs more in people treated with conventional therapy than in people treated with laparoscopic adjustable gastric banding surgery."], "hard_negative": "General exercise therapy is more effective than rotator cuff exercises in reducing pain and improving function of the shoulder."}
{"query_id": "454", "query_text": "General exercise therapy is more effective than scapular stabilizer exercises in reducing pain and improving function of the shoulder.", "negative": "Interleukin-18 plays an important role in the pathogenesis of atherosclerosis.", "negatives": ["Interleukin-18 plays an important role in the pathogenesis of atherosclerosis.", "Polymeal nutrition increases cardiovascular mortality.", "The DEXI promoter region is bound by multiple transcription factors in a murine haematopoietic progenitor cell line.", "Clathrin stabilizes the spindle fiber apparatus during mitosis.", "Upregulation of dynein in Drosophila neurons increases the number of microtubule plus-ends growing toward the cell body of each neuron.", "Decreased conversion of PGE 2 to PPARy ligand 15-ket-PGE 2 causes accumulation of PGE.", "Incidence of 10/66 dementia is lower than the incidence of DSM-IV dementia.", "Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 inhibit West Nile virus replication in cortical neurons.", "The G34R/V mutation does not create a hypomethylated phenotype at the H3K36 histone.", "Sepsis related mortality has remained stable between 2009-2014."], "hard_negatives": ["General exercise therapy is more effective than scapular stabilizer exercises in reducing pain and improving function of the shoulder.", "Scapular stabilizer exercises are more effective than general exercise therapy in reducing pain and improving function of the shoulder.", "General exercise therapy is more effective than rotator cuff exercises in reducing pain and improving function of the shoulder.", "Rotator cuff exercises are more effective than general exercise therapy in reducing pain and improving function of the shoulder.", "Surgical treatment is not superior to non-surgical in treating adults with displaced fractures of the proximal humerus.", "Amitriptyline is an effective treatment for chronic tension-type headaches.", "There is a positive correlation between hip fractures and statin use.", "Roughly 55% of women with chronic pelvic pain have no underlying pathology.", "Medications to treat obesity do not have side effects.", "Antidepressants reduce the severity of migraines."], "hard_negative": "General exercise therapy is more effective than scapular stabilizer exercises in reducing pain and improving function of the shoulder."}
{"query_id": "455", "query_text": "Genes involved in pre-mRNA splicing have a significant impact on genome stability.", "negative": "Human embryonic stem cells give rise to cell types from all three embryonic germ layers.", "negatives": ["Human embryonic stem cells give rise to cell types from all three embryonic germ layers.", "The cytokine receptor which regulates chemotaxis and formation of lymph nodes is involved in production of myeloperoxidase in the left atrium.", "NR5A2 is important in reverse cholesterol transport in humans.", "Cellular clocks are not predictive of mitosis timing in NIH 3T3 cells.", "CHOP is a general endoplasmic reticulum stress marker.", "FoxO3a activation in neuronal death is inhibited by reactive oxygen species (ROS).", "PGE 2 suppresss intestinal tumor growth by altering the expression of tumor suppressing and DNA repair genes.", "Oxidative DNA damage inhibits STING signalling.", "Stiff substrates inhibit mesodermal differentiation by degrading beta-catenin in an integrin-dependent manner.", "Acute ablation of Snail in the embryonic cortex affects the proliferation and number of embryonic cortical precursors."], "hard_negatives": ["Genes involved in pre-mRNA splicing have a significant impact on genome stability.", "Pre-mRNAs associated with spliceosomal components are more stable than unassociated splicing substrates.", "Pre-mRNAs associated with spliceosomal components are less stable than unassociated splicing substrates.", "Trans-acting factors, such as lncRNAs, influence mRNA translation.", "miRNAs regulate a unique suite of mRNAs to maintain homeostasis in cells.", "Understanding epigenetic regulation of replication is essential for the reational design of episomally replicating vectors.", "Long - range chromatin interactions regulate transcription.", "Cellular differentiation of embryonic stem cells is accompanied by changes in replication timing, transcription and nuclear localization.", "Pseudoknots are not evolutionarily conserved in most eukaryotes.", "Sequence conservation in gene regulatory regions between species is a high-accuracy predictor of conserved functionality."], "hard_negative": "Genes involved in pre-mRNA splicing have a significant impact on genome stability."}
{"query_id": "456", "query_text": "Genes regulated by Esrrb transcription factor are sensitive to Mbd3 function.", "negative": "Formation of N-terminal pyroglutamate by glutamine cyclase (GC) competes with NTAQ1 for Nt-Gln substrates.", "negatives": ["Formation of N-terminal pyroglutamate by glutamine cyclase (GC) competes with NTAQ1 for Nt-Gln substrates.", "Suboptimal nutrition is a leading cause of premature death", "Increased flux of microbial products suppresses immune responses.", "70% of burn patients are admitted for hospitalization and further treatment after appearing at hospital emergency wards or outpatient clinics.", "The density of cytokine receptor bearing cells has no effect on the distance over which cytokines act.", "Nuclear transfer from adult human fibroblasts to human oocytes can give rise to blastocysts containing expandable pluripotent cells.", "The innate immune response struggles to remove small numbers of parasites.", "Individuals with Alzheimers who participate in six months of physical activity improve cognitive function for up to 18 months.", "CCL19 is predominantly present within dLNs.", "Bariatric surgery leads to positive outcomes in mental health."], "hard_negatives": ["Genes regulated by Esrrb transcription factor are sensitive to Mbd3 function.", "MUC1-C activates the NF-\u03baB p65 signaling pathway by interacting with I\u03baB kinase \u00df.", "KRT17 modulates the expression of the transcriptional regulator AIRE in diseased epithelia.", "The PPR MDA5 has twenty N-terminal CARD domains.", "The DEXI promoter region is bound by multiple transcription factors in a murine haematopoietic progenitor cell line.", "JMJD6 catalyzes the hydroxylation of C-terminal lysine and supresses transcriptional activity.", "TNFAIP3 is a glioblastoma tumor suppressor.", "Foxp3 enables the expression of transcriptional regulators implicated in memory T cell development.", "Mutations in RIM1 raise levels of IME1 RNA.", "Mutations in RIM1 decrease levels of IME1 RNA."], "hard_negative": "Genes regulated by Esrrb transcription factor are sensitive to Mbd3 function."}
{"query_id": "458", "query_text": "Genetic deficiency of mast cells leads to decreased weight gain in a mouse model of diet-induced obesity.", "negative": "There is a positive correlation between hip fractures and statin use.", "negatives": ["There is a positive correlation between hip fractures and statin use.", "Increased conversion of PGE 2 to PPARy ligand 15-ket-PGE 2 causes accumulation of PGE.", "Alirocumab treatment reduces apo(a) fractional clearance rate.", "Treatment with a protein named FN restores regenerative abilities of aged muscles.", "Dscam1 acts as a hypervariable pattern-recognition receptor for the immune system.", "eRNAs influence is linked to senescence, aging, and carcinogenesis.", "Replacement of OCT4 and SOX2 genes with GATA3 has the ability to reprogram human cells.", "PRC1-bound plasmids sediment at a slower rate in unbound plasmids than in sucrose gradients.", "Forkhead 0 (fox0) transcription factors are involved in apoptosis.", "Inhibiting focal adhesion formation increases the rate at which cells convert mechanical strain into inflammation and fibrosis."], "hard_negatives": ["Genetic deficiency of mast cells leads to decreased weight gain in a mouse model of diet-induced obesity.", "Excess gestational weight gain is associated with obesity-related pregnancy outcomes.", "Ten percent (10%) of kidney cancers in the UK are attributable to excess weight.", "Women with a lower birth weight are more likely to develop breast cancer later in life.", "Birth-weight is negatively associated with breast cancer.", "Autophagy deficiency in the liver increases vulnerability to insulin resistance.", "Medications to treat obesity do not have side effects.", "Medications to treat obesity have unwanted side effects.", "IL-10 production by monocytes inhibits CD4 + T cell response.", "Exercise increases cancer mortality rates among Chinese citizens."], "hard_negative": "Genetic deficiency of mast cells leads to decreased weight gain in a mouse model of diet-induced obesity."}
{"query_id": "461", "query_text": "Genetic deletion of JAM-A increases gut permeability.", "negative": "Reduction of Rpl38 alters the composition of the Hox gene mRNAs translation in mice without lowering overall protein synthesis.", "negatives": ["Reduction of Rpl38 alters the composition of the Hox gene mRNAs translation in mice without lowering overall protein synthesis.", "H.pylori-mediated gastric cancer occurs due to the accumulation of mutations in host epithelial cells.", "IL-6 signaling plays a major role in atherosclerotic cardiovascular disease.", "Antimicrobial agents are more effective due to the pressure of antimicrobial usage.", "Intra-cerebroventricular infusion of amyloid-\u03b2 oligomers reduces expression of fibronectin type-III domain-containing protein 5 mRNA in mice hippocampi.", "Increased lipolysis leads to higher P38 phosphorylation in adipose tissue.", "Ethanol stress increases the expression of SRL in bacteria.", "Emodin forms hydrogen bonds with residues involved in PGAM1 substrate binding.", "Overexpressing Cnp1 N-tail variants rescues the temperature-sensitive growth defect of scm3-139.", "The minor G allele of FOXO3 downregulates pro-inflammatory cytokines."], "hard_negatives": ["Genetic deletion of JAM-A increases gut permeability.", "Mutations in RIM1 decrease levels of IME1 RNA.", "Mutations in RIM1 raise levels of IME1 RNA.", "Alirocumab treatment reduces apo(a) fractional clearance rate.", "Glycan adaptation involves insertion-deletion events.", "Exhaustion of B cells contributes to poor Ab response in HIV-infected individuals.", "Increased flux of microbial products provokes immune responses.", "Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection increases dissemination of Salmonella Typhimurium from the gut.", "Acute ablation of Snail in the embryonic cortex affects the proliferation and number of embryonic cortical precursors.", "Cytochrome c is transferred from cytosol to the mitochondrial intermembrane space during apoptosis."], "hard_negative": "Genetic deletion of JAM-A increases gut permeability."}
{"query_id": "463", "query_text": "Genomic aberrations of metastases provide information for targeted therapy.", "negative": "LRBA prevents CTLA - 4 recycling.", "negatives": ["LRBA prevents CTLA - 4 recycling.", "Cellular differentiation of embryonic stem cells is accompanied by changes in replication timing, transcription and nuclear localization.", "Folate and vitamin B12 levels influence the association between homocysteine and preeclampsia.", "Ribosome-inactivating protein-2 (RIP-2) interacts with the p75 NTR death domain", "The combination of physical examinations with C-reactive protein values do not improve the accuracy of radiographic verified pneumonia predictions.", "In transgenic mice harboring green florescent protein under the control of the Sox2 promoter, more than 50 percent of the cells with green florescent colocalize with cell proliferation markers.", "The H2A-H2B eviction defect is compensated for by other histone chaperone(s).", "Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes epithelial damage.", "The mean suicide rate in women is higher after miscarriage than live birth.", "LSD1-positive promoters are associated with RNA polymerase II"], "hard_negatives": ["Genomic aberrations of metastases provide information for targeted therapy.", "Monoclonal antibody targeting of N-cadherin encourages metastasis.", "Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission.", "Nonsteroidal antinflammatory drugs show potential anticancer indications.", "Repressing IL-18 has negative effects on atherosclerotic lesion composition and progression.", "Systemic immunosuppressive (IS) therapy increases the chance of cancer mortality in patients with inflammatory eye disease (IED)", "Deletion of ATM and Rad3 related protein is not predictive of acute tissue loss.", "Incidence of 10/66 dementia is lower than the incidence of DSM-IV dementia.", "Systemic immunosuppressive (IS) therapy does not enhance the chance of cancer mortality in patients with inflammatory eye disease (IED)", "Incidence of 10/66 dementia is higher than the incidence of DSM-IV dementia."], "hard_negative": "Genomic aberrations of metastases provide information for targeted therapy."}
{"query_id": "466", "query_text": "Genomic sequences involved in alternative splicing responsible for Hutchinson-Gilford progeria syndrome (HGPS) are abundant in the ''progerinonly'' allele of Lmna knock-in models.", "negative": "Activated Cdk5 phosphorylates the ATM protein in response to DNA damage.", "negatives": ["Activated Cdk5 phosphorylates the ATM protein in response to DNA damage.", "Ly6C hi monocytes have a higher inflammatory capacity than Ly6C lo monocytes.", "There is no association between HNF4A mutations and diabetes risks.", "4-PBA treatment decreases endoplasmic reticulum stress in response to general endoplasmic reticulum stress markers.", "LRBA promotes CTLA - 4 recycling.", "TRAP+ osteoclasts regulate mature osteoblast maintenance.", "Nonhypertensive people who are 55 years old have a 90% chance of developing hypertension during their lifetime.", "Genomic sequences involved in alternative splicing responsible for Hutchinson-Gilford progeria syndrome (HGPS) are abundant in the ''progerinonly'' allele of Lmna knock-in models.", "Rotator cuff exercises are more effective than general exercise therapy in reducing pain and improving function of the shoulder.", "Distant CREs are less conserved among species."], "hard_negatives": ["Genomic sequences involved in alternative splicing responsible for Hutchinson-Gilford progeria syndrome (HGPS) are abundant in the ''progerinonly'' allele of Lmna knock-in models.", "Lmna knock-in models are appropriate for testing therapeutic approaches against Hutchinson-Gilford progeria syndrome (HGPS).", "A single nucleotide variant the gene DGKK is strongly associated with increased risk of hypospadias.", "A strong bias in the phage genome locations where the spacers were derived has been observed in many CRISPR subtypes that confer the immunity to phage.", "Increased mobility of retrotransposons is assosciated with mutation and higher tumorigenesis rates.", "Increased mobility of retrotransposons does not lead to mutation and higher tumorigenesis rates.", "Pre-mRNAs associated with spliceosomal components are less stable than unassociated splicing substrates.", "Genes involved in pre-mRNA splicing have a significant impact on genome stability.", "Pre-mRNAs associated with spliceosomal components are more stable than unassociated splicing substrates.", "Reduction of Rpl38 alters the composition of the Hox gene mRNAs translation in mice without lowering overall protein synthesis."], "hard_negative": "Genomic sequences involved in alternative splicing responsible for Hutchinson-Gilford progeria syndrome (HGPS) are abundant in the ''progerinonly'' allele of Lmna knock-in models."}
{"query_id": "469", "query_text": "Glial calcium waves influence seizures.", "negative": "90% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.", "negatives": ["90% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.", "Hypocretin neurones suppress panicprone state in rats.", "Mice lacking Sirt1 in Sf1-expressing neurons are immune to diet-induced obesity and insulin resistance.", "Alteration of origin firing causes changes in termination zones of Okazaki fragments.", "61% of colorectal cancer patients are diagnosed with regional or distant metastases.", "Participants who quit smoking reduce lung cancer risk by approximately 50%.", "Egr3 regulates the homeostasis of B and T cells.", "Human embryonic stem cells have the capacity to give rise to differentiated progeny representative of all three embryonic germ layers.", "Rhythmic expression of Cry1 translates directly into a circadian regulation of cAMP signaling in gluconeogenesis.", "Treatment with a protein named FN impairs regenerative abilities of aged muscles."], "hard_negatives": ["Glial calcium waves influence seizures.", "Headaches are correlated with cognitive impairment.", "Hypothalamic glutamate neurotransmission is unrelated to energy balance.", "Energy balance requires hypothalamic glutamate neurotransmission.", "Occipital activation levels are associated with auditory spatial performance in parietal regions of the brain.", "Insulin effects appetite via ventral tegmental neurons.", "Migraine with aura is associated with ischemic stroke.", "Myelin sheaths play a role in action potential propagation.", "Patients with panic anxiety show decreased CSF levels of hypocretin.", "Sudden death can occur in patients with orthostatic hypertension without cardiac conduction abnormalities."], "hard_negative": "Glial calcium waves influence seizures."}
{"query_id": "470", "query_text": "Glioblastoma multiforme (GBM) is characterized by extensive invasion, rapid growth, necrosis, and angiogenesis.", "negative": "APOE4 expression in iPSC-derived neurons results in decreased tau phosphorylation.", "negatives": ["APOE4 expression in iPSC-derived neurons results in decreased tau phosphorylation.", "ART substantially reduces infectiveness of HIV-positive people.", "Mutations in RIM1 raise levels of IME1 RNA.", "Satellite cell dysfunction is a key factor in sarcopenia development.", "Bariatric surgery reduces postmenopausal breast cancer.", "Lack of FGF21 in mice leads to reduced lifespan.", "T cell receptor /CD3 microdomains are required to induce the immunologic synapse.", "Algerian physicians constitue the largest component of sub-Saharan Africa-trained physicians in the United States.", "Upon viral challenge, influenza-specific memory CD4+ T cells greatly enhance the early production of inflammatory chemokines in the lung.", "Decreased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm."], "hard_negatives": ["Glioblastoma multiforme (GBM) is characterized by extensive invasion, rapid growth, necrosis, and angiogenesis.", "Cancer-associated fibroblasts (CAFs) are constituents of tumor microenvironments", "Cancer-associated fibroblasts (CAFs) have no known interaction with cancer cells in the formation and activation of CAFs.", "Cancer-associated fibroblasts (CAFs) interact with cancer cells to mediate formation and activation of CAFs.", "Cancer cells can stimulate the accumulation of intra-tumoural myeloid-derived suppressor cells by promoting granulocyte colony stimulating factor production.", "Microglia are an innate immune cell type of the central nervous system.", "Tuberculosis-induced granulomas express different immune system protein signatures than the surrounding tissue.", "Fibroblast Growth Factor is a ligand which signals through receptor tyrosine kinases.", "Mutations in G-Beta protein GNB1 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.", "G-CSF increases the expansion and infiltration of MDSCs into tumors."], "hard_negative": "Glioblastoma multiforme (GBM) is characterized by extensive invasion, rapid growth, necrosis, and angiogenesis."}
{"query_id": "472", "query_text": "Glucose restriction to 0.05% reduces RLS (replicative life span) by 20-40% in S. cerevisiae.", "negative": "CD44v6 is not associated with constitutive and reprogrammed cancer stem cells driving cancer metastasis.", "negatives": ["CD44v6 is not associated with constitutive and reprogrammed cancer stem cells driving cancer metastasis.", "The ability of activator E2Fs in preventing cell death is limited to terminally differentiated cells.", "The morphology change from large white adipocytes to small brown adipocytes is a sign of decreased energy expenditure potential in white adipose tissue.", "Vitamin D is an important factor in the relationship between calcium and parathyroid hormone.", "Taxation of sugar-sweetened beverages reduced the incidence rate of type II diabetes in India.", "Chemical injury represses transglutaminase 2 activity.", "G-CSF increases the expansion and infiltration of MDSCs into tumors.", "Urbanization is an important risk factor related to the transmission of dengue fever.", "Expression of MSX2 is induced 3 hours after the addition of BMP4, which is earlier than T and CDX2.", "H4 G94P proteins suppress degradation of free histones via Rad53-dependent mechanisms."], "hard_negatives": ["Glucose restriction to 0.05% reduces RLS (replicative life span) by 20-40% in S. cerevisiae.", "Ethanol stress reduces the expression of SRL in bacteria.", "Transcription rates in S. cerevisiae range between 0.7 and 2 kb/min.", "Transcription rates in S. cerevisiae range between 7 and 12 kb/min.", "Ethanol stress increases the expression of SRL in bacteria.", "The Snf1 complex regulates carbon and energy metabolism in baker's yeast (Saccharomyces cerevisiae).", "Ethanol stress lowers the expression of PSP in bacteria.", "Healthy volunteers exhibit rapid and transient increase of cellular ATP after being bolus-injected with fructose.", "Ethanol stress increases the expression of PSP in bacteria.", "Ethanol stress increases the expression of IBP in bacteria."], "hard_negative": "Glucose restriction to 0.05% reduces RLS (replicative life span) by 20-40% in S. cerevisiae."}
{"query_id": "473", "query_text": "Glycan adaptation involves insertion-deletion events.", "negative": "Mice are incapable of producing neutralizing antibodies in reponse to the Chikungunya virus (CHIKV) produced in mosquitos.", "negatives": ["Mice are incapable of producing neutralizing antibodies in reponse to the Chikungunya virus (CHIKV) produced in mosquitos.", "Removal of H3K9me3 improves reprogramming efficiency in human somatic cell nuclear transfer experiments.", "Bariatric surgery reduces colorectal cancer.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have shorter lifetime exposure to estrogen due to a decreased reproductive period.", "Intra-cerebroventricular infusion of amyloid-\u03b2 oligomers reduces expression of fibronectin type-III domain-containing protein 5 mRNA in mice hippocampi.", "Rapamycin increases the concentration of triacylglycerols in fruit flies.", "90% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.", "Monoclonal antibody targeting of N-cadherin encourages castration resistance.", "A strong bias in the phage genome locations where the spacers were derived has been observed in many CRISPR subtypes that confer the immunity to phage.", "Ethanol stress reduces the expression of SRL in bacteria."], "hard_negatives": ["Glycan adaptation involves insertion-deletion events.", "The deamination of cytidine to uridine on the minus strand of viral DNA can inactivate the viral genome by inducing G-to-A mutations.", "Glycan adaptation is rarely observed in the B-cell repertoire.", "The latent infection of myeloid cells with human cytomegalovirus induces a number of changes in gene expression.", "Monoclonal antibody targeting of N-cadherin encourages metastasis.", "Deleting Raptor increases G-CSF levels.", "Monoclonal antibody targeting of N-cadherin inhibits growth.", "Recognition of start codons depends on the translation initiation factor IF3.", "Trans-acting factors, such as lncRNAs, influence mRNA translation.", "A strong bias in the phage genome locations where the spacers were derived has been observed in many CRISPR subtypes that confer the immunity to phage."], "hard_negative": "Glycan adaptation involves insertion-deletion events."}
{"query_id": "474", "query_text": "Glycan adaptation is rarely observed in the B-cell repertoire.", "negative": "7-day-old adult Caenorhabditis elegans exhibit approximately 75% of the learning capacity seen in 1-day old adults.", "negatives": ["7-day-old adult Caenorhabditis elegans exhibit approximately 75% of the learning capacity seen in 1-day old adults.", "The C-type lectin receptor (CLEC-2) rearranges the actin cytoskeleton in dendritic cells to promote efficient motility along stromal surfaces.", "Broadly HIV-1 Neutralizing Antibodies (bnAb) 10EB have no affinity for phospholipids.", "Deregulation of HAND2 is a crucial step in endometrial carcinogenesis in mice.", "Normal expression of RUNX1 causes tumorsupressing effects.", "Neutrophils produce IL-1\u03b2 in response to large particles.", "Chlamydia trachomatis is most prevalent in the UK among individuals in their 50s and 60s.", "Physical activity level has no association with the difference in maximal oxygen consumption between black and white youth.", "Lack of FGF21 in mice leads to reduced lifespan.", "Lack of FGF21 in mice leads to reduced lifespan."], "hard_negatives": ["Glycan adaptation is rarely observed in the B-cell repertoire.", "Glycan adaptation involves insertion-deletion events.", "Chronic HIV stimulation of B cells leads to the premature exhaustion of B cells.", "Varying expression levels of EBI2 affect the positioning and migration of B cells.", "Exhaustion of B cells contributes to poor Ab response in HIV-infected individuals.", "The deamination of cytidine to uridine on the minus strand of viral DNA can inactivate the viral genome by inducing G-to-A mutations.", "A strong bias in the phage genome locations where the spacers were derived has been observed in many CRISPR subtypes that confer the immunity to phage.", "The innate immune response struggles to remove small numbers of parasites.", "B cells go though plasmablast differentiation and antibody production by continuous expression of EBI2.", "The latent infection of myeloid cells with human cytomegalovirus induces a number of changes in gene expression."], "hard_negative": "Glycan adaptation is rarely observed in the B-cell repertoire."}
{"query_id": "479", "query_text": "Gpr124 increases BBB breakdown in mouse models of ischemic stroke.", "negative": "Measuring routine outcomes is more beneficial to clinical practice than assessing treatment adherence.", "negatives": ["Measuring routine outcomes is more beneficial to clinical practice than assessing treatment adherence.", "A deficiency of folate increases blood levels of homocysteine.", "Glial calcium waves influence seizures.", "LDL cholesterol has a causal role in the development of cardiovascular disease.", "Removal of H3K9me3 by ectopic expression of other H3K9 demethylases improves reprogramming efficiency in SCNT experiments.", "Forkhead 0 (fox0) transcription factors are involved in cellular differentiation.", "Bariatric surgery leads to positive outcomes in mental health.", "Normal granulomas form in the presence of TNF in Zebrafish.", "Expression of oncolytic virus antigens as peptides makes relapse more likely.", "Homozygous deletion of murine Sbds gene from osterix-expressing mesenchymal stem and progenitor cells (MPCs) induces oxidative stress."], "hard_negatives": ["Gpr124 increases BBB breakdown in mouse models of ischemic stroke.", "Gpr124 suppresses BBB breakdown in mouse models of ischemic stroke.", "Activated Cdk5 phosphorylates the ATM protein in response to DNA damage.", "Mice without IFN-\u03b3 or its receptor are highly susceptible to EAM induced with \u03b1-MyHC/CFA.", "Antiretroviral therapy increases rates of tuberculosis across a broad range of CD4 strata.", "p16INK4A degradation is encoded by CDKN2A.", "Toll-like receptor (TLR) signaling is involved in the pathogenesis of human MDS.", "A mutation in HNF4A leads to an increased risk of developing diabetes by the age of 14 years.", "Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes fibrosis.", "A mutation in HNF4A leads to an increased risk of diabetes by the age of 14 years."], "hard_negative": "Gpr124 increases BBB breakdown in mouse models of ischemic stroke."}
{"query_id": "480", "query_text": "Gpr124 suppresses BBB breakdown in mouse models of ischemic stroke.", "negative": "Long - range chromatin interactions regulate transcription.", "negatives": ["Long - range chromatin interactions regulate transcription.", "Oxidative DNA damage inhibits STING signalling.", "Expression of oncolytic virus antigens as peptides permits additional protection against relapse.", "Acute ablation of Snail in the embryonic cortex affects the proliferation and number of embryonic cortical precursors.", "Basophils promote disease development in patients with systemic lupus erythematosus (SLE).", "BiP is a general endoplasmic reticulum stress marker.", "Tuberculosis incidence occurs at higher rates in more sparsely populated areas in the UK.", "Pseudogene PTENP1 encodes a transcript that regulates PTEN expression.", "Sudden death can occur in patients with orthostatic hypertension without cardiac conduction abnormalities.", "Beta-band coherence is diminished for visible stimuli over invisible stimuli."], "hard_negatives": ["Gpr124 suppresses BBB breakdown in mouse models of ischemic stroke.", "Gpr124 increases BBB breakdown in mouse models of ischemic stroke.", "Activated Cdk5 phosphorylates the ATM protein in response to DNA damage.", "Toll-like receptor (TLR) signaling is involved in the pathogenesis of human MDS.", "Mice without IFN-\u03b3 or its receptor are highly susceptible to EAM induced with \u03b1-MyHC/CFA.", "p16INK4A degradation is encoded by CDKN2A.", "Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes fibrosis.", "RAD52 is involved in break-induced DNA replication (BIR).", "Mice that lack Interferon-\u03b3 or its receptor are highly susceptible to experimental autoimmune myocarditis.", "The DdrB protein from Deinococcus radiodurans functions as a pentamer."], "hard_negative": "Gpr124 suppresses BBB breakdown in mouse models of ischemic stroke."}
{"query_id": "481", "query_text": "Guanine nucleotide dissociation inhibitor (Rho-GDI) interacts with the p75 NTR death domain", "negative": "Weighed food records (WFR) result in high completion since they're cheap to run and impose low participant burden.", "negatives": ["Weighed food records (WFR) result in high completion since they're cheap to run and impose low participant burden.", "Ly49Q directs the organization of neutrophil polarization by regulating membrane raft functions.", "MICAL redox enzymes regulate actin dynamics in many cell types.", "Risedronate increases risk of vertebral and non-vertebral fractures.", "Diabetes remission occurs less in people treated with conventional therapy than in people treated with laparoscopic adjustable gastric banding surgery.", "Acute ablation of Snail in the embryonic cortex affects the proliferation and number of embryonic cortical precursors.", "Albendazole is used to treat soil-transmitted helminths.", "Glucose restriction to 0.05% reduces RLS (replicative life span) by 20-40% in S. cerevisiae.", "Patients with common epithelial cancers are less likely to have an emergency event as their first hospital admission if they live in resource-deprived areas.", "Birth-weight is negatively associated with breast cancer."], "hard_negatives": ["Guanine nucleotide dissociation inhibitor (Rho-GDI) interacts with the p75 NTR death domain", "Ribosome-inactivating protein-2 (RIP-2) interacts with the p75 NTR death domain", "p75 NTR - associated cell death executor (NADE) interacts with the p75 NTR death domain", "Formation of N-terminal pyroglutamate by glutamine cyclase (GC) competes with NTAQ1 for Nt-Gln substrates.", "Guanine nucleotide exchange factors (GEFs) mediate RhoA activation in response to tensional forces on fibronectin-binding integrins.", "MUC1-C activates the NF-\u03baB p65 signaling pathway by interacting with I\u03baB kinase \u00df.", "Mutations in G-Beta protein GNB1 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.", "Replacement of histone H2A with H2A.Z accelerates gene activation in yeasts by destabilizing +1 nucleosomes.", "5'-nucleotidase metabolizes 6MP.", "Lysine histone demethylase inhibitor JIB 04 is inactive against KDM5A."], "hard_negative": "Guanine nucleotide dissociation inhibitor (Rho-GDI) interacts with the p75 NTR death domain"}
{"query_id": "482", "query_text": "Guanine nucleotide exchange factors (GEFs) mediate RhoA activation in response to tensional forces on fibronectin-binding integrins.", "negative": "The latent infection of myeloid cells with human cytomegalovirus induces a number of changes in gene expression.", "negatives": ["The latent infection of myeloid cells with human cytomegalovirus induces a number of changes in gene expression.", "Two variants of chromosome 6q21 are associated with radiation therapy-induced second malignancies in pediatric Hodgkin lymphoma patients.", "A high microerythrocyte count protects against severe anemia in homozygous alpha (+)- thalassemia trait subjects.", "Integrated care is successful at tackling multiple comorbidities.", "Tumor development occurs in conjunction with upregulation of pro-inflammatory cytokines.", "Induced hepatic stem cells possess the potential to differentiate into cholangiocytic cells.", "Persistor cells are one reason for incomplete responses to Tyrosine kinase inhibitor (TKI) therapy in cancer patients.", "Rapamycin delays aging in fruit flies.", "Low nucleosome occupancy correlates with high methylation levels across species.", "Foxp3 enables the expression of transcriptional regulators implicated in memory T cell development."], "hard_negatives": ["Guanine nucleotide exchange factors (GEFs) mediate RhoA activation in response to tensional forces on fibronectin-binding integrins.", "Guanine nucleotide dissociation inhibitor (Rho-GDI) interacts with the p75 NTR death domain", "Kir7.1 modulates channel activity by the G protein-coupled melanocortin-4 receptor (MC4R) in the paraventricular nucleus of the hypothalamus.", "The C-type lectin receptor (CLEC-2) rearranges the actin cytoskeleton in dendritic cells to promote efficient motility along stromal surfaces.", "Upregulation of dynein in Drosophila neurons increases the number of microtubule plus-ends growing toward the cell body of each neuron.", "Pyridostatin stabilizes the G - quadruplex in the telomeric region.", "MICAL redox enzymes regulate actin dynamics in many cell types.", "Formation of N-terminal pyroglutamate by glutamine cyclase (GC) competes with NTAQ1 for Nt-Gln substrates.", "Ly49Q directs the organization of neutrophil polarization by regulating membrane raft functions.", "Intra-cerebroventricular infusion of amyloid-\u03b2 oligomers increases expression of fibronectin type-III domain-containing protein 5 mRNA in mice hippocampi."], "hard_negative": "Guanine nucleotide exchange factors (GEFs) mediate RhoA activation in response to tensional forces on fibronectin-binding integrins."}
{"query_id": "483", "query_text": "H.pylori-mediated gastric cancer occurs due to the accumulation of mutations in host epithelial cells.", "negative": "The recruitment of Wdr5 to its target loci depends on Kat8.", "negatives": ["The recruitment of Wdr5 to its target loci depends on Kat8.", "Oxidative DNA damage activates STING signalling.", "Upregulation of PD1 causes the upregulation of Satb1.", "Crossover hot spots are found within gene promoters in Saccharomyces cerevisiae.", "The risk of cancer rises with level of alcohol consumption.", "Osteocytes have an essential role in G-CSF induced HSPC mobilization.", "Mitochondria play a trivial role in calcium homeostasis.", "Incidence of heart failure increased by 10% in women since 1979.", "Suboptimal nutrition is a leading cause of premature death", "Major vault protein (MVP) leads to more aggressive tumors by regulating the sorting of tumor suppressive miR-193a into extracellular vesicles (EVs)."], "hard_negatives": ["H.pylori-mediated gastric cancer occurs due to the accumulation of mutations in host epithelial cells.", "Gastric infection with Helicobacter pylori increases risk of gastric cancer in humans.", "Gastric infection with Helicobacter pylori decreases risk of gastric cancer in humans.", "In breast cancer, the loss of myoepithelial cells slows the transition of ductal carcinoma in situ to invasive carcinoma.", "In breast cancer, the loss of myoepithelial cells promotes the transition of ductal carcinoma in situ to invasive carcinoma.", "Many cytokines that are produced by cancer cells also contribute to carcinogenesis.", "Depletion of nitric oxide is responsible for vasospasm.", "The latent infection of myeloid cells with human cytomegalovirus induces a number of changes in gene expression.", "Cancer-associated fibroblasts (CAFs) have no known interaction with cancer cells in the formation and activation of CAFs.", "Cancer-associated fibroblasts (CAFs) interact with cancer cells to mediate formation and activation of CAFs."], "hard_negative": "H.pylori-mediated gastric cancer occurs due to the accumulation of mutations in host epithelial cells."}
{"query_id": "484", "query_text": "H4 G94P proteins induce chromatin assembly, which increases free histones.", "negative": "Propriospinal interneurons that play a role in the plastic reorganization of spinal circuits are integral for recovery from spinal cord injury.", "negatives": ["Propriospinal interneurons that play a role in the plastic reorganization of spinal circuits are integral for recovery from spinal cord injury.", "Bacteriophagaes MS2 and Q\u03b2 are members of the Leviviridae.", "Inhibiting focal adhesion formation increases the rate at which cells convert mechanical strain into inflammation and fibrosis.", "FACT and other histone chaperone(s) compensate for Histone 2A (H2A)-histone 2B (H2B) dimer eviction during the histone exchange process.", "Malaria has a high vectorial capacity.", "Transplanted human glial progenitor cells can mature in their host animal.", "p16INK4A degradation is  linked to an abnormal wound response caused by the microinvasive step of advanced Oral Potentially Malignant Lesions (OPMLs).", "1 in 5 million in UK have abnormal PrP positivity.", "Measuring routine outcomes is more beneficial to clinical practice than assessing treatment adherence.", "Venules have less significant tunica adventitia than arterioles."], "hard_negatives": ["H4 G94P proteins induce chromatin assembly, which increases free histones.", "H4 G94P proteins inhibit chromatin assembly, which decreases free histones.", "H4 G94P proteins induce degradation of free histones via Rad53-dependent mechanisms.", "H4 G94P proteins suppress degradation of free histones via Rad53-dependent mechanisms.", "The G34R/V mutation does not create a hypomethylated phenotype at the H3K36 histone.", "The G34R/V mutation creates a hypomethylated phenotype at the H3K36 histone.", "Replacement of histone H2A with H2A.Z accelerates gene activation in yeasts by destabilizing +1 nucleosomes.", "FACT and other histone chaperone(s) compensate for Histone 2A (H2A)-histone 2B (H2B) dimer eviction during the histone exchange process.", "The H2A-H2B eviction defect is compensated for by other histone chaperone(s).", "Removal of H3K9me3 by ectopic expression of other H3K9 demethylases improves reprogramming efficiency in SCNT experiments."], "hard_negative": "H4 G94P proteins induce chromatin assembly, which increases free histones."}
{"query_id": "485", "query_text": "H4 G94P proteins induce degradation of free histones via Rad53-dependent mechanisms.", "negative": "Bariatric surgery reduces colorectal cancer.", "negatives": ["Bariatric surgery reduces colorectal cancer.", "Patients in stable partnerships have a slower progression from HIV to AIDS.", "Intra-cerebroventricular infusion of amyloid-\u03b2 oligomers increases expression of fibronectin type-III domain-containing protein 5 mRNA in mice hippocampi.", "Low nucleosome occupancy correlates with high methylation levels across species.", "Genes regulated by Esrrb transcription factor are sensitive to Mbd3 function.", "PGE 2 suppresss intestinal tumor growth by altering the expression of tumor suppressing and DNA repair genes.", "Environmental factors can influence the development of breast cancer.", "De novo assembly of sequence data has fewer specific contigs than unassembled sequence data.", "Suboptimal nutrition is a leading cause of premature death", "Varying expression levels of EBI2 affect the positioning and migration of B cells."], "hard_negatives": ["H4 G94P proteins induce degradation of free histones via Rad53-dependent mechanisms.", "H4 G94P proteins suppress degradation of free histones via Rad53-dependent mechanisms.", "H4 G94P proteins induce chromatin assembly, which increases free histones.", "H4 G94P proteins inhibit chromatin assembly, which decreases free histones.", "The G34R/V mutation does not create a hypomethylated phenotype at the H3K36 histone.", "The G34R/V mutation creates a hypomethylated phenotype at the H3K36 histone.", "Replacement of histone H2A with H2A.Z accelerates gene activation in yeasts by destabilizing +1 nucleosomes.", "Removal of H3K9me3 by ectopic expression of other H3K9 demethylases improves reprogramming efficiency in SCNT experiments.", "The H2A-H2B eviction defect is compensated for by other histone chaperone(s).", "Removal of H3K9me3 by ectopic expression of other H3K9 demethylases decreases reprogramming efficiency in SCNT experiments."], "hard_negative": "H4 G94P proteins induce degradation of free histones via Rad53-dependent mechanisms."}
{"query_id": "486", "query_text": "H4 G94P proteins inhibit chromatin assembly, which decreases free histones.", "negative": "Varying expression levels of EBI2 affect the positioning and migration of B cells.", "negatives": ["Varying expression levels of EBI2 affect the positioning and migration of B cells.", "Alteration of origin firing causes changes in termination zones of Okazaki fragments.", "The PRR MDA5 has a C-terminal domain.", "Neutrophil extracellular trap (NET) antigens may contain the targeted autoantigens PR3 and MPO.", "The mean suicide rate in women is higher after miscarriage than live birth.", "CCL19 is predominantly present within dLNs.", "Type 1 Diabetes is associated with subtle perturbations in T reg development.", "H4 G94P proteins inhibit chromatin assembly, which decreases free histones.", "The minor G allele of FOXO3 downregulates pro-inflammatory cytokines.", "Removal of H3K9me3 improves reprogramming efficiency in human somatic cell nuclear transfer experiments."], "hard_negatives": ["H4 G94P proteins inhibit chromatin assembly, which decreases free histones.", "H4 G94P proteins induce chromatin assembly, which increases free histones.", "H4 G94P proteins induce degradation of free histones via Rad53-dependent mechanisms.", "H4 G94P proteins suppress degradation of free histones via Rad53-dependent mechanisms.", "The G34R/V mutation does not create a hypomethylated phenotype at the H3K36 histone.", "The G34R/V mutation creates a hypomethylated phenotype at the H3K36 histone.", "Replacement of histone H2A with H2A.Z accelerates gene activation in yeasts by destabilizing +1 nucleosomes.", "FACT and other histone chaperone(s) compensate for Histone 2A (H2A)-histone 2B (H2B) dimer eviction during the histone exchange process.", "The H2A-H2B eviction defect is compensated for by other histone chaperone(s).", "L3MBTL2 binds to H2AK119Ub marked chromatin to form a PRC1 complex."], "hard_negative": "H4 G94P proteins inhibit chromatin assembly, which decreases free histones."}
{"query_id": "487", "query_text": "H4 G94P proteins suppress degradation of free histones via Rad53-dependent mechanisms.", "negative": "A T helper 2 cell (Th2) environment impedes disease development in patients with systemic lupus erythematosus (SLE).", "negatives": ["A T helper 2 cell (Th2) environment impedes disease development in patients with systemic lupus erythematosus (SLE).", "ART substantially reduces infectiveness of HIV-positive people.", "Diabetes remission occurs less in people treated with conventional therapy than in people treated with laparoscopic adjustable gastric banding surgery.", "ART substantially reduces infectiveness of HIV-positive people.", "RANK-RANKL pathway signalling is linked to development of Aire-expressing medullary thymic epithelial cells.", "Replacement of OCT4 and SOX2 genes with GATA3 is not capable of reprogramming human cells.", "Physical activity level has no association with the difference in maximal oxygen consumption between black and white youth.", "Differentiated E2f-1, -2, -3 TKO cells in the intestine do not exhibit apoptosis.", "7-day-old adult Caenorhabditis elegans exhibit approximately 5% of the learning capacity seen in 1-day old adults.", "Lipopolysaccharides have an inflammation independent effect on kidney barrier function."], "hard_negatives": ["H4 G94P proteins induce degradation of free histones via Rad53-dependent mechanisms.", "H4 G94P proteins suppress degradation of free histones via Rad53-dependent mechanisms.", "H4 G94P proteins induce chromatin assembly, which increases free histones.", "H4 G94P proteins inhibit chromatin assembly, which decreases free histones.", "The G34R/V mutation does not create a hypomethylated phenotype at the H3K36 histone.", "The G34R/V mutation creates a hypomethylated phenotype at the H3K36 histone.", "Replacement of histone H2A with H2A.Z accelerates gene activation in yeasts by destabilizing +1 nucleosomes.", "The H2A-H2B eviction defect is compensated for by other histone chaperone(s).", "Removal of H3K9me3 by ectopic expression of other H3K9 demethylases improves reprogramming efficiency in SCNT experiments.", "Removal of H3K9me3 by ectopic expression of other H3K9 demethylases decreases reprogramming efficiency in SCNT experiments."], "hard_negative": "H4 G94P proteins induce degradation of free histones via Rad53-dependent mechanisms."}
{"query_id": "488", "query_text": "HAND2 methylation is a key step in early endometrial carcinogenesis.", "negative": "DUSP4 downregulation deactivates the Ras-ERK pathway", "negatives": ["DUSP4 downregulation deactivates the Ras-ERK pathway", "British male students are bullied more than British female students.", "British female students are bullied more than British male students.", "Upregulation of PD1 causes the upregulation of Satb1.", "In rhesus macaques, daily subcutaneous injections of emtricitabine are ineffective at protecting against rectally transmitted simian-human immunodeficiency virus.", "Ethanol stress lowers the expression of PSP in bacteria.", "Ethanol stress increases the expression of PSP in bacteria.", "Students who perform poorly in the early years of medical school are at increased risk for professional misconduct later in their careers.", "Microcin J25 encourages nucleoside triphosphate (NTP) binding.", "Eilat virus (EILV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in nonhuman primates."], "hard_negatives": ["HAND2 methylation is a key step in early endometrial carcinogenesis.", "Deregulation of HAND2 is a crucial step in endometrial carcinogenesis in mice.", "NR5A2 does not play a role in development of endometrial tissues.", "Many cytokines that are produced by cancer cells also contribute to carcinogenesis.", "Decrease of p62 in prostate tumor stroma results in defective autophagy.", "Increase of p62 in prostate tumor stroma results in defective autophagy.", "PGE 2 suppresss intestinal tumor growth by altering the expression of tumor suppressing and DNA repair genes.", "EGR2 is important to myelination of the peripheral nervous system.", "eRNAs influence is linked to senescence, aging, and carcinogenesis.", "Foxk2 regulates autophagy genes in muscle cells and fibroblast cells."], "hard_negative": "HAND2 methylation is a key step in early endometrial carcinogenesis."}
{"query_id": "489", "query_text": "HIV trans-activator protein (TAT) effectively transports large and small molecules across cellular membranes into larger populations of neurons.", "negative": "Oxidative phosphorylation is one of the primary glycometabolic pathways in cells.", "negatives": ["Oxidative phosphorylation is one of the primary glycometabolic pathways in cells.", "The NF-\u03baB essential modulator gene induces intestinal inflammation by promoting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death.", "50% of patients exposed to radiation have activated markers of mesenchymal stem cells.", "The generation of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells.", "G-CSF increases the expansion and infiltration of MDSCs into tumors.", "The RANK-RANK-Ligand (RANKL) pathway is involved in the development of Aire-expressing medullary thymic epithelial cells (mTECs).", "The tissue surrounding the granuloma in an immune cell induces an anti-inflammatory immune response.", "Klf2 is important for proper myeloid cell function.", "CDK6 shows improved binding to loss-of-function variants of p18 INK4C.", "Lmna knock-in models are appropriate for testing therapeutic approaches against Hutchinson-Gilford progeria syndrome (HGPS)."], "hard_negatives": ["HIV trans-activator protein (TAT) effectively transports large and small molecules across cellular membranes into larger populations of neurons.", "Mice lacking Sirt1 in Sf1-expressing neurons are immune to diet-induced obesity and insulin resistance.", "CD28 signals regulate trafficking of murine auto-reactive T cells into target tissues.", "Mice lacking Sirt1 in Sf1-expressing neurons have increased susceptibility to diet-induced obesity and insulin resistance.", "Major antigen-induced signals from the T cell receptor and secondary signals from costimulatory receptors are required for T cell activation.", "MeCP2 influences the synaptic maturation of neurons.", "Many transmembrane receptors transmit signals by long-range conformational changes in the association of alpha-helices across the plasma membrane.", "Upregulation of dynein in Drosophila neurons increases the number of microtubule plus-ends growing toward the cell body of each neuron.", "Microglia are an innate immune cell type of the central nervous system.", "Tirasemtiv targets fast-twitch muscle."], "hard_negative": "HIV trans-activator protein (TAT) effectively transports large and small molecules across cellular membranes into larger populations of neurons."}
{"query_id": "490", "query_text": "HNF4A mutations are associated with macrosomia in infancy.", "negative": "Bacterial meningitis can be diagnosed on the basis of positive cerebrospinal fluid (CSF) cultures.", "negatives": ["Bacterial meningitis can be diagnosed on the basis of positive cerebrospinal fluid (CSF) cultures.", "Weighed food records (WFR) result in poor completion since they're costly to run and impose high participant burden.", "miRNAs enforce homeostasis by suppressing low-level ''leaky'' transcription.", "TNFAIP3 is a glioblastoma tumor suppressor.", "V-9302 inhibits antitumor responses by decreasing cell death and oxidative stress.", "Destination container port throughput(CPT) is negatively related to dengue virus (DENV-1) diffusion in air traffic shipments.", "Differentiation of progenitor cells to myeloid cells is skewed when insulin signaling is suppressed.", "Sepsis related mortality has risen from 2009 to 2014.", "The DEXI promoter region is bound by multiple transcription factors in a murine haematopoietic progenitor cell line.", "90% of patients with melanoma and an objective response to PD-1 blockade will experience a progression in their melanoma."], "hard_negatives": ["HNF4A mutations are associated with macrosomia in infancy.", "Carriers of HNF4A mutations are at reduced risk for diabetes.", "A mutation in HNF4A leads to an increased risk of developing diabetes by the age of 14 years.", "A mutation in HNF4A leads to an increased risk of diabetes by the age of 14 years.", "There is no association between HNF4A mutations and diabetes risks.", "A deficiency of vitamin B12 decreases blood levels of homocysteine.", "The G34R/V mutation creates a hypomethylated phenotype at the H3K36 histone.", "Mutations in G-Beta protein GNB1 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.", "The G34R/V mutation does not create a hypomethylated phenotype at the H3K36 histone.", "The generation of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells."], "hard_negative": "HNF4A mutations are associated with macrosomia in infancy."}
{"query_id": "492", "query_text": "HOXB4 facilitates HSC expansion when co-cultured with HSCs.", "negative": "Cost effectiveness evaluations based on cRCT data lack external validity.", "negatives": ["Cost effectiveness evaluations based on cRCT data lack external validity.", "Incidence of sepsis has fallen substantially from 2009 to 2014.", "Repressing IL-18 has negative effects on atherosclerotic lesion composition and progression.", "Inhibiting HDAC6 increases survival of mice with ARID1A mutated tumors.", "Physical activity level is associated with the difference in maximal oxygen consumption between black and white youth.", "Continued HHV-8 transmission among MSM in San Francisco may be explained by urogenital contact.", "Continued HHV-8 transmission among MSM in San Francisco may be explained by urogenital contact.", "Early patent ductus ateriosus (PDA) screening increases in-hospital mortality.", "The minor G allele of FOXO3 is related to less severe symptoms of Crohn's Disease.", "Formation of N-terminal pyroglutamate by glutamine cyclase (GC) competes with NTAQ1 for Nt-Gln substrates."], "hard_negatives": ["HOXB4 facilitates HSC expansion when co-cultured with HSCs.", "HOXB4 is a highly expressed component of cellular secretome from fetal liver cell populations.", "Osteocytes have an essential role in G-CSF induced HSPC mobilization.", "Klf4 is important for proper myeloid cell differentiation.", "Induced hepatic stem cells possess the potential to differentiate into cholangiocytic cells.", "Klf4 is not required for proper myeloid cell differentiation.", "LRBA promotes CTLA - 4 recycling.", "Reduced phosphorylation of PP2A increases HDAC4 dephosphorylation by enhancing PP2A-HDAC4 interaction.", "GATA3 regulates self-renewal capacity in bone marrow hematopoietic stem cells.", "G-CSF increases the expansion and infiltration of MDSCs into tumors."], "hard_negative": "HOXB4 facilitates HSC expansion when co-cultured with HSCs."}
{"query_id": "493", "query_text": "HOXB4 is a highly expressed component of cellular secretome from fetal liver cell populations.", "negative": "Weighed food records (WFR) result in high completion since they're cheap to run and impose low participant burden.", "negatives": ["Weighed food records (WFR) result in high completion since they're cheap to run and impose low participant burden.", "Physical activity level is associated with the difference in maximal oxygen consumption between black and white youth.", "Emodin forms hydrogen bonds with residues involved in PGAM1 substrate binding.", "HNF4A mutations are associated with macrosomia in infancy.", "Genetic deletion of JAM-A increases gut permeability.", "Ly6C hi monocytes have a higher inflammatory capacity than Ly6C lo monocytes.", "Adult tissue-resident macrophages stem from the embryonal yolk sac and fetal liver.", "RAD52 is involved in break-induced DNA replication (BIR).", "Active Ly49Q induces neutrophil polarization.", "Varenicline monotherapy is more effective after 26 weeks of treatment compared to combination nicotine replacement therapies with varenicline or bupropion."], "hard_negatives": ["HOXB4 is a highly expressed component of cellular secretome from fetal liver cell populations.", "HOXB4 facilitates HSC expansion when co-cultured with HSCs.", "Klf4 is important for proper myeloid cell differentiation.", "Klf2 is important for proper myeloid cell function.", "Klf4 is not required for proper myeloid cell differentiation.", "Adult tissue-resident macrophages stem from the embryonal yolk sac and fetal liver.", "Adult tissue-resident macrophages stem from the embryonal yolk sac and fetal liver.", "Bone marrow cells don't contribute to adult macrophage compartments.", "GATA3 regulates cell cycle progression in bone marrow hematopoietic stem cells.", "Foxk2 regulates autophagy genes in muscle cells and fibroblast cells."], "hard_negative": "HOXB4 is a highly expressed component of cellular secretome from fetal liver cell populations."}
{"query_id": "494", "query_text": "HSCT-T dosage may not be diagnostic if the onset of symptoms occurs less than 3 hours before AMI.", "negative": "The World Health Organization's (WHO) data collection process is biased downward by unequal selection of larger outbreaks.", "negatives": ["The World Health Organization's (WHO) data collection process is biased downward by unequal selection of larger outbreaks.", "Noninvasive positive pressure ventilation is not predictive of acute respiratory failure after solid organ transplantation.", "The proliferative capacity of progenitors is regulated cell-autonomously.", "A mutation in HNF4A leads to an increased risk of diabetes by the age of 14 years.", "ERAP1 SNPs are epistatic to HLA alleles for ankylosing spondylitis.", "Chemical injury represses transglutaminase 2 activity.", "4-PBA treatment decreases endoplasmic reticulum stress in response to general endoplasmic reticulum stress markers.", "Differentiation of progenitor cells to myeloid cells is skewed when insulin signaling is suppressed.", "Increase of p62 in prostate tumor stroma results in defective autophagy.", "Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes fibrosis."], "hard_negatives": ["HSCT-T dosage may not be diagnostic if the onset of symptoms occurs less than 3 hours before AMI.", "Amitriptyline is an effective treatment for chronic tension-type headaches.", "Toll-like receptor (TLR) signaling is involved in the pathogenesis of human MDS.", "CD28 initiates tonic signaling in conventional T cells, which causes an exhaustion phenotype and limited efficiency.", "In melanoma, anti-CTLA-4 treatment reinvigorates exhausted PD-1+Eomes+CD8 T cells.", "Including pharmacists in rounding teams does not alter the incidence of adverse drug events (ADEs).", "The most prevalent adverse events to Semaglutide are cardiovascular.", "Type 1 Diabetes is associated with subtle perturbations in T reg development.", "Major antigen-induced signals from the T cell receptor and secondary signals from costimulatory receptors are required for T cell activation.", "Certain immunomodulator-human dialyzable leukocyte extract (hDLE) peptides are recognized by toll-like receptors (TLRs) on macrophages and dendritic cells."], "hard_negative": "HSCT-T dosage may not be diagnostic if the onset of symptoms occurs less than 3 hours before AMI."}
{"query_id": "495", "query_text": "Having a main partner improves HIV outcomes.", "negative": "The repeat-variable diresidue (RVD) in the loop of Transcription-Activator Like (TAL) effectors specifies the nucleotides-amino acid contact at the target promoter element.", "negatives": ["The repeat-variable diresidue (RVD) in the loop of Transcription-Activator Like (TAL) effectors specifies the nucleotides-amino acid contact at the target promoter element.", "Pharmacist attendance at ward rounds reduces adverse events in wards.", "Sepsis related mortality has risen from 2009 to 2014.", "Klf4 is important for proper myeloid cell differentiation.", "The DESMOND program demonstrates no significant impact on biochemical outcomes.", "Angiotensin converting enzyme inhibitors are associated with decreased risk for functional renal insufficiency.", "IL-10 production by monocytes inhibits CD4 + T cell response.", "Toll-like receptor (TLR) signaling is involved in the pathogenesis of human MDS.", "Rapid phosphotransfer rates are correlated with histidine kinase regulator specificity.", "Activation of PPM1D enhances p53 function."], "hard_negatives": ["Having a main partner improves HIV outcomes.", "Having a main partner worsens HIV outcomes.", "Patients in stable partnerships progress from HIV to death at the same rate as patients not in partnerships.", "Patients in stable partnerships have a slower progression from HIV to AIDS.", "Exhaustion of B cells contributes to poor Ab response in HIV-infected individuals.", "ART substantially reduces infectiveness of HIV-positive people.", "Chronic HIV stimulation of B cells leads to the premature exhaustion of B cells.", "ART has no effect on the infectiveness of HIV-positive people.", "Self-advocacy training is effective at decreasing homelessness.", "Antiretroviral therapy increases rates of tuberculosis across a broad range of CD4 strata."], "hard_negative": "Having a main partner improves HIV outcomes."}
{"query_id": "498", "query_text": "Having a main partner worsens HIV outcomes.", "negative": "HOXB4 is a highly expressed component of cellular secretome from fetal liver cell populations.", "negatives": ["HOXB4 is a highly expressed component of cellular secretome from fetal liver cell populations.", "The minor G allele of FOXO3 downregulates pro-inflammatory cytokines.", "Risedronate increases risk of vertebral and non-vertebral fractures.", "For every 1,000 children with cerebral palsy, more than 300 of them are premature or underweight at birth.", "The predominant localization of Linc00173 is in mononuclear macrophage nuclei.", "cSMAC formation represses weak ligand signalling.", "Increased LDL receptors plays a role in the reduction of plasma Lp(a).", "Egr3 regulates the homeostasis of B and T cells.", "FoxO3a activation in neuronal death is inhibited by reactive oxygen species (ROS).", "Low nucleosome occupancy correlates with high methylation levels across species."], "hard_negatives": ["Having a main partner worsens HIV outcomes.", "Having a main partner improves HIV outcomes.", "Patients in stable partnerships progress from HIV to death at the same rate as patients not in partnerships.", "Patients in stable partnerships have a slower progression from HIV to AIDS.", "Chronic HIV stimulation of B cells leads to the premature exhaustion of B cells.", "Exhaustion of B cells contributes to poor Ab response in HIV-infected individuals.", "ART has no effect on the infectiveness of HIV-positive people.", "ART substantially reduces infectiveness of HIV-positive people.", "Antiretroviral therapy increases rates of tuberculosis across a broad range of CD4 strata.", "Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission."], "hard_negative": "Having a main partner worsens HIV outcomes."}
{"query_id": "499", "query_text": "HbA1c consistently overestimates glycemic control in black individuals with Sickle cell trait (SCT).", "negative": "Intra-cerebroventricular infusion of amyloid-\u03b2 oligomers increases expression of fibronectin type-III domain-containing protein 5 mRNA in mice hippocampi.", "negatives": ["Intra-cerebroventricular infusion of amyloid-\u03b2 oligomers increases expression of fibronectin type-III domain-containing protein 5 mRNA in mice hippocampi.", "Ly6C hi monocytes have a higher inflammatory capacity than Ly6C lo monocytes.", "Environmental factors can influence the development of breast cancer.", "Induced hepatic stem cells possess the potential to differentiate into cholangiocytic cells.", "Human embryonic stem cells give rise to cell types from all three embryonic germ layers.", "ART substantially reduces infectiveness of HIV-positive people.", "C2 works synergistically with A-769662 to activate dephosphorylated AMPK.", "Cellular clocks are associated with mitosis timing in NIH 3T3 cells.", "The World Health Organization's (WHO) data collection process is biased downward by unequal selection of larger outbreaks.", "p16INK4A degradation is encoded by CDKN2A."], "hard_negatives": ["HbA1c consistently overestimates glycemic control in black individuals with Sickle cell trait (SCT).", "A high microerythrocyte count protects against severe anemia in homozygous alpha (+)- thalassemia trait subjects.", "The M2-phenotype in brown adipose tissue macrophages increases brown adipose tissue thermogenic activity.", "Mutant mice lacking SVCT2 have severely reduced ascorbic acid levels in both brain and adrenals.", "The morphology change from large white adipocytes to small brown adipocytes is a sign of decreased energy expenditure potential in white adipose tissue.", "Ca2+ cycling controls whole-body energy homeostasis in beige fat.", "The morphology change from large white adipocytes to small brown adipocytes is a sign of increased energy expenditure potential in white adipose tissue.", "Physical activity level has no association with the difference in maximal oxygen consumption between black and white youth.", "The minor G allele of FOXO3 is related to less severe symptoms of Crohn's Disease.", "A deficiency of vitamin B12 decreases blood levels of homocysteine."], "hard_negative": "HbA1c consistently overestimates glycemic control in black individuals with Sickle cell trait (SCT)."}
{"query_id": "500", "query_text": "Headaches are correlated with cognitive impairment.", "negative": "PKG-la does not have a large impact on expression of spinal long term potentiation in PGK-la knockout mice.", "negatives": ["PKG-la does not have a large impact on expression of spinal long term potentiation in PGK-la knockout mice.", "British female students are bullied more than British male students.", "Upregulation of PD1 causes the upregulation of Satb1.", "A deficiency of folate increases blood levels of homocysteine.", "Pyridostatin decreases telomere fragility in BRCA2-deficient cells.", "4-PBA treatment raises endoplasmic reticulum stress in response to general endoplasmic reticulum stress markers.", "Long chain polyunsaturated fatty acids supplementation is associated with lower rates of atopic eczema at 1 year.", "The generation of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells.", "miR-142-5P is a known regulator of raised body temperature.", "Tuberculosis incidence occurs at higher rates in more sparsely populated areas in the UK."], "hard_negatives": ["Headaches are correlated with cognitive impairment.", "Physical activity does not improve cognitive function in individuals with Alzheimers.", "Antidepressants increase the severity of migraines.", "Antidepressants reduce the severity of migraines.", "Individuals with Alzheimers who participate in six months of physical activity improve cognitive function for up to 18 months.", "Asymptomatic visual impairment screening in elderly populations leads to improved vision.", "Patients with panic anxiety show decreased CSF levels of hypocretin.", "Exposure to fine particulate air pollution is unrelated to anxiety prevalence.", "Glial calcium waves influence seizures.", "Cognitive behavioral therapy is an ineffective treatment for insomnia"], "hard_negative": "Headaches are correlated with cognitive impairment."}
{"query_id": "504", "query_text": "Healthy volunteers exhibit rapid and transient increase of cellular ATP after being bolus-injected with fructose.", "negative": "Ribosomopathies have a high degree of cell and tissue specific pathology.", "negatives": ["Ribosomopathies have a high degree of cell and tissue specific pathology.", "Long chain polyunsaturated fatty acids supplementation is associated with lower rates of atopic eczema at 1 year.", "Nonsteroidal antinflammatory drugs are ineffective as cancer treatments.", "Interleukin-18 plays an important role in the pathogenesis of atherosclerosis.", "Pseudogene PTENP1 encodes a transcript that regulates PTEN expression.", "AMP-activated protein kinase (AMPK) activation reduces inflammation-related fibrosis in the lungs.", "Tirasemtiv has no effect on cardiac muscle.", "Asymptomatic visual impairment screening in elderly populations leads to improved vision.", "The NF-\u03baB essential modulator gene induces intestinal inflammation by promoting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death.", "The minor G allele of FOXO3 up-regulates IL-10."], "hard_negatives": ["Healthy volunteers exhibit rapid and transient increase of cellular ATP after being bolus-injected with fructose.", "Ca2+ cycling controls whole-body energy homeostasis in beige fat.", "Rhythmic expression of Cry1 translates directly into a circadian regulation of cAMP signaling in hepatic glucose metabolism.", "Energy balance requires hypothalamic glutamate neurotransmission.", "Glucose restriction to 0.05% reduces RLS (replicative life span) by 20-40% in S. cerevisiae.", "Ethanol stress increases the expression of IBP in bacteria.", "The M2-phenotype in brown adipose tissue macrophages increases brown adipose tissue thermogenic activity.", "The morphology change from large white adipocytes to small brown adipocytes is a sign of increased energy expenditure potential in white adipose tissue.", "Ethanol stress increases the expression of PSP in bacteria.", "Hypothalamic glutamate neurotransmission is unrelated to energy balance."], "hard_negative": "Healthy volunteers exhibit rapid and transient increase of cellular ATP after being bolus-injected with fructose."}
{"query_id": "505", "query_text": "Helicobacter pylori-induced aberrant NF-kB-dependent expression of activation-induced cytidine deaminase contributes to the mutagenesis of host DNA.", "negative": "R2D2 stops miRNA production by increasing the selectivity of Dcr2 for long dsRNA.", "negatives": ["R2D2 stops miRNA production by increasing the selectivity of Dcr2 for long dsRNA.", "During non-homologous end joining, the ligation step is not as tolerant of disrepairs and other distortions when joining 3' of strand breaks as compared to 5' strand breaks.", "The NF-\u03baB essential modulator gene prevents intestinal inflammation by inhibiting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death.", "H4 G94P proteins induce degradation of free histones via Rad53-dependent mechanisms.", "In breast cancer, the loss of myoepithelial cells promotes the transition of ductal carcinoma in situ to invasive carcinoma.", "Genes regulated by Esrrb transcription factor are sensitive to Mbd3 function.", "Basophils promote disease development in patients with systemic lupus erythematosus (SLE).", "Mutations in RIM1 raise levels of IME1 RNA.", "Glioblastoma multiforme (GBM) is characterized by extensive invasion, rapid growth, necrosis, and angiogenesis.", "The minor G allele of FOXO3 downregulates pro-inflammatory cytokines."], "hard_negatives": ["Helicobacter pylori-induced aberrant NF-kB-dependent expression of activation-induced cytidine deaminase contributes to the mutagenesis of host DNA.", "Replacement of histone H2A with H2A.Z accelerates gene activation in yeasts by destabilizing +1 nucleosomes.", "Citrullinated proteins externalized in neutrophil extracellular traps act indirectly to perpetuate the inflammatory cycle via induction of autoantibodies.", "RA activation of DIF2 and NB4 cells induces hallmarks of transcriptionally active promoters.", "Lysine histone demethylase inhibitor JIB 04 is inactive against KDM5A.", "Cancer cells can stimulate the accumulation of intra-tumoural myeloid-derived suppressor cells by promoting granulocyte colony stimulating factor production.", "Activation of the Rac1 homolog CED-10 kills viable cells in SRGP-1 mutant Caenorhabditis elegans.", "Removal of H3K9me3 by ectopic expression of other H3K9 demethylases decreases reprogramming efficiency in SCNT experiments.", "The generation of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells.", "Removal of H3K9me3 by ectopic expression of other H3K9 demethylases improves reprogramming efficiency in SCNT experiments."], "hard_negative": "Helicobacter pylori-induced aberrant NF-kB-dependent expression of activation-induced cytidine deaminase contributes to the mutagenesis of host DNA."}
{"query_id": "506", "query_text": "Helminths interfere with immune system control of coinfections by microbial pathogens 16.", "negative": "A T helper 2 cell (Th2) environment impedes disease development in patients with systemic lupus erythematosus (SLE).", "negatives": ["A T helper 2 cell (Th2) environment impedes disease development in patients with systemic lupus erythematosus (SLE).", "Up-regulation of the p53 pathway and related molecular events speeds cancer progression.", "CD28 initiates tonic signaling in conventional T cells, which causes an exhaustion phenotype and limited efficiency.", "Ribosomal protein (RP) expression is controlled in part by stress-activated regulators.", "The DEXI promoter region is bound by multiple transcription factors in a murine haematopoietic progenitor cell line.", "Microglia are an innate immune cell type of the central nervous system.", "The cytokine receptor which regulates chemotaxis and formation of lymph nodes is involved in production of myeloperoxidase in the left atrium.", "CD44v6 is not associated with constitutive and reprogrammed cancer stem cells driving cancer metastasis.", "Satellite cell dysfunction is a key factor in sarcopenia development.", "The gene daf-16, which encodes forkhead Box O (FOXO), is required for all phenotypes associated with reduced insulin/insulin-like growth factor (Igf) signaling."], "hard_negatives": ["Helminths interfere with immune system control of coinfections by microbial pathogens 16.", "Albendazole is used to treat soil-transmitted helminths.", "Bacteriophagaes MS2 and Q\u03b2 are members of the Leviviridae.", "Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 inhibit West Nile virus replication in cortical neurons.", "Commelina yellow mottle virus (ComYMV) has three typical badnavirus ORFs, capable of encoding proteins 23, 15, and 216 kD.", "Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection increases dissemination of Salmonella Typhimurium from the gut.", "Nonhuman primates are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.", "Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection decreases dissemination of Salmonella Typhimurium from the gut.", "The deamination of cytidine to uridine on the minus strand of viral DNA can inactivate the viral genome by inducing G-to-A mutations.", "Eilat virus (EILV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in nonhuman primates."], "hard_negative": "Helminths interfere with immune system control of coinfections by microbial pathogens 16."}
{"query_id": "509", "query_text": "Hematopoietic Stem Cell purification reaches purity rates above 90%.", "negative": "Cellular clocks are not predictive of mitosis timing in NIH 3T3 cells.", "negatives": ["Cellular clocks are not predictive of mitosis timing in NIH 3T3 cells.", "miRNAs regulate a unique suite of mRNAs to maintain homeostasis in cells.", "Stiff substrates inhibit mesodermal differentiation by degrading beta-catenin in an integrin-dependent manner.", "Physical activity level has no association with the difference in maximal oxygen consumption between black and white youth.", "GATA3 regulates cell cycle progression in bone marrow hematopoietic stem cells.", "Chinese individuals with TT homozygosity in the MTHFR gene are less vulnerable to strokes caused by low levels of folate intake.", "Helminths interfere with immune system control of coinfections by microbial pathogens 16.", "Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 inhibit West Nile virus replication in cortical neurons.", "Neutrophil extracellular trap (NET) antigens may contain the targeted autoantigens PR3 and MPO.", "Students who perform poorly in the early years of medical school are at increased risk for professional misconduct later in their careers."], "hard_negatives": ["Hematopoietic Stem Cell purification reaches purity rates above 90%.", "A low percentage of hematopoietic progenitor cells are susceptible to HIV-1 infection ex vivo.", "Induced hepatic stem cells possess the potential to differentiate into hepatocytic cells.", "Induced hepatic stem cells possess the potential to differentiate into cholangiocytic cells.", "Androgenetic haploid mouse embryonic stem cells (ESCs) can be derived and genetically manipulated in vitro.", "HOXB4 facilitates HSC expansion when co-cultured with HSCs.", "Human embryonic stem cells have the capacity to give rise to differentiated progeny representative of all three embryonic germ layers.", "GATA3 regulates cell cycle progression in bone marrow hematopoietic stem cells.", "High levels of CRP lead to a higher risk of exacerbations in chronic obstructive pulmonary disease (COPD).", "Specialized functional cell types can be derived from human pluripotent stem cells."], "hard_negative": "Hematopoietic Stem Cell purification reaches purity rates above 90%."}
{"query_id": "515", "query_text": "High levels of CRP lead to a higher risk of exacerbations in chronic obstructive pulmonary disease (COPD).", "negative": "0-dimensional biomaterials lack inductive properties.", "negatives": ["0-dimensional biomaterials lack inductive properties.", "Reducing H3k4me3 methylation induces mouse epiblast stem cells to naive pluripotency efficiently.", "Charcoal is an effective treatment for acute paraquat poisoning.", "Myelin sheaths play a role in action potential propagation.", "Acute ablation of Snail in the embryonic cortex affects the proliferation and number of embryonic cortical precursors.", "Reduced responsiveness to interleukin-2 in regulatory T cells is associated with autoimmune diseases such as Type 1 Diabetes.", "Microglia are an innate immune cell type of the peripheral nervous system.", "Cell autonomous sex determination in somatic cells occurs in Galliformes.", "Cancer cells can stimulate the accumulation of intra-tumoural myeloid-derived suppressor cells by promoting granulocyte colony stimulating factor production.", "There is no relation between Erythromycin use and hypertrophic pyloric stenosis."], "hard_negatives": ["High levels of CRP lead to a higher risk of exacerbations in chronic obstructive pulmonary disease (COPD).", "CRP is positively correlated with postoperative mortality following Coronary Artery Bypass Graft (CABG) surgery.", "Decreased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm.", "Increased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm.", "Diabetic patients with acute coronary syndrome experience decreased short-term and long-term risk for bleeding events.", "AMP-activated protein kinase (AMPK) activation reduces inflammation-related fibrosis in the lungs.", "Exposure to fine particulate air pollution is unrelated to anxiety prevalence.", "Participants who quit smoking reduce lung cancer risk by approximately 50%.", "Decreased conversion of PGE 2 to PPARy ligand 15-ket-PGE 2 causes accumulation of PGE.", "Increased conversion of PGE 2 to PPARy ligand 15-ket-PGE 2 causes accumulation of PGE."], "hard_negative": "High levels of CRP lead to a higher risk of exacerbations in chronic obstructive pulmonary disease (COPD)."}
{"query_id": "523", "query_text": "Higher plasma levels of I-carnitine, when associated with trimethylamine N-oxide, are negatively correlated with cardiovascular events in humans.", "negative": "N348I mutations reduce resistance to nevirapine.", "negatives": ["N348I mutations reduce resistance to nevirapine.", "Glycan adaptation involves insertion-deletion events.", "Ca2+ cycling controls whole-body energy homeostasis in beige fat.", "Tuberculosis incidence occurs at higher rates in more sparsely populated areas in the UK.", "Alirocumab treatment reduces apo(a) fractional clearance rate.", "70% of burn patients are admitted for hospitalization and further treatment after appearing at hospital emergency wards or outpatient clinics.", "Upon viral challenge, influenza-specific memory CD4+ T cells greatly enhance the early production of inflammatory chemokines in the lung.", "Chlamydia trachomatis is most prevalent in the UK among individuals in their 50s and 60s.", "The risk of female prisoners harming themselves is ten times that of male prisoners.", "Transcription rates in S. cerevisiae range between 7 and 12 kb/min."], "hard_negatives": ["Higher plasma levels of I-carnitine, when associated with trimethylamine N-oxide, are negatively correlated with cardiovascular events in humans.", "Higher plasma levels of I-carnitine, when associated with trimethylamine N-oxide, are positively correlated with cardiovascular events in humans.", "Omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegetarians.", "Omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegans.", "Omnivores produce less trimethylamine N-oxide from dietary I-carnitine than vegans.", "Sildenafil worsens erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.", "LDL cholesterol has a causal role in the development of cardiovascular disease.", "A deficiency of folate increases blood levels of homocysteine.", "There is no increased risk of hypospadias with clomiphene.", "A deficiency of vitamin B12 decreases blood levels of homocysteine."], "hard_negative": "Higher plasma levels of I-carnitine, when associated with trimethylamine N-oxide, are negatively correlated with cardiovascular events in humans."}
{"query_id": "524", "query_text": "Higher plasma levels of I-carnitine, when associated with trimethylamine N-oxide, are positively correlated with cardiovascular events in humans.", "negative": "Folate and vitamin B12 levels influence the association between homocysteine and preeclampsia.", "negatives": ["Folate and vitamin B12 levels influence the association between homocysteine and preeclampsia.", "The microtubule-dependent delivery and secretion of matrix metalloproteases (MMPs) is partially responsible for the disassembly of adhesion sites.", "RANK-RANKL pathway signalling has no known association with development of Aire-expressing medullary thymic epithelial cells.", "The proliferative capacity of progenitors is regulated cell-autonomously.", "The effect of Lipopolysaccharides on kidney barrier function is dependent on inflammation levels.", "In S. cerevisiae, the absence of RNA surveillance pathways causes sensitivity to high iron conditions.", "Aged patients are more susceptible to ischaemia/reperfusion injury.", "Over half of the gabonese children with Schimmelpenning-Feuerstein-Mims syndrome (SFM) had a plasma lactate of more than 5mmol/L.", "CDK6 shows improved binding to loss-of-function variants of p18 INK4C.", "AMP-activated protein kinase (AMPK) activation reduces inflammation-related fibrosis in the lungs."], "hard_negatives": ["Higher plasma levels of I-carnitine, when associated with trimethylamine N-oxide, are positively correlated with cardiovascular events in humans.", "Higher plasma levels of I-carnitine, when associated with trimethylamine N-oxide, are negatively correlated with cardiovascular events in humans.", "Omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegetarians.", "Omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegans.", "Omnivores produce less trimethylamine N-oxide from dietary I-carnitine than vegans.", "Sildenafil worsens erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.", "LDL cholesterol has a causal role in the development of cardiovascular disease.", "A deficiency of folate increases blood levels of homocysteine.", "There is no increased risk of hypospadias with clomiphene.", "A deficiency of vitamin B12 decreases blood levels of homocysteine."], "hard_negative": "Higher plasma levels of I-carnitine, when associated with trimethylamine N-oxide, are positively correlated with cardiovascular events in humans."}
{"query_id": "526", "query_text": "Homozygous deletion of murine Sbds gene from osterix-expressing mesenchymal stem and progenitor cells (MPCs) induces oxidative stress.", "negative": "During non-homologous end joining, the ligation step is not as tolerant of disrepairs and other distortions when joining 5' of strand breaks as compared to 3' strand breaks.", "negatives": ["During non-homologous end joining, the ligation step is not as tolerant of disrepairs and other distortions when joining 5' of strand breaks as compared to 3' strand breaks.", "Ribosomopathies have a high degree of cell and tissue specific pathology.", "Lack of FGF21 in mice increases life expectancy.", "Tirasemtiv targets cardiac muscle.", "p75 NTR - associated cell death executor (NADE) interacts with the p75 NTR death domain", "Mice defective for deoxyribonucleic acid (DNA) polymerase I (polI) fail to reveal increased sensitivity to ionizing radiation (IR).", "miR-142-5P is a temperature-sensitive microRNA (miRNA).", "Men are more susceptible to death due to pneumonia when compared to women.", "In the UK, drowning affects boys and girls equally.", "Students who perform poorly in the early years of medical school are at increased risk for professional misconduct later in their careers."], "hard_negatives": ["Homozygous deletion of murine Sbds gene from osterix-expressing mesenchymal stem and progenitor cells (MPCs) induces oxidative stress.", "Increased mobility of retrotransposons is assosciated with mutation and higher tumorigenesis rates.", "Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection increases dissemination of Salmonella Typhimurium from the gut.", "Autologous transplantation of mesenchymal stem cells has better graft function than induction therapy with anti-interleukin-2 receptor antibodies.", "Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection decreases dissemination of Salmonella Typhimurium from the gut.", "Increased mobility of retrotransposons does not lead to mutation and higher tumorigenesis rates.", "The latent infection of myeloid cells with human cytomegalovirus induces a number of changes in gene expression.", "The DEXI promoter region is bound by multiple transcription factors in a murine haematopoietic progenitor cell line.", "siRNA knockdown of A20 slows tumor progression in an in vivo murine xenograft model.", "siRNA knockdown of A20 accelerates tumor progression in an in vivo murine xenograft model."], "hard_negative": "Homozygous deletion of murine Sbds gene from osterix-expressing mesenchymal stem and progenitor cells (MPCs) induces oxidative stress."}
{"query_id": "529", "query_text": "Human embryonic stem cells give rise to cell types from all three embryonic germ layers.", "negative": "Pre-mRNAs associated with spliceosomal components are less stable than unassociated splicing substrates.", "negatives": ["Pre-mRNAs associated with spliceosomal components are less stable than unassociated splicing substrates.", "Higher plasma levels of I-carnitine, when associated with trimethylamine N-oxide, are positively correlated with cardiovascular events in humans.", "Tuberculosis-induced granulomas express different immune system protein signatures than the surrounding tissue.", "Patients in stable partnerships progress from HIV to death at the same rate as patients not in partnerships.", "The risk of breast cancer among parous women decreases with placental weight of pregnancies.", "C2 works synergistically with A-769662 to activate dephosphorylated AMPK.", "Pseudogene PTENP1 encodes a transcript that regulates PTEN expression.", "Lack of FGF21 in mice leads to atherosclerotic plaque formation.", "The composition of myosin-II isoform switches from the A isoform to the B isoform during hematopoietic differentiation.", "Whole brain radiotherapy increases the occurrence of new brain metastases."], "hard_negatives": ["Human embryonic stem cells give rise to cell types from all three embryonic germ layers.", "Human embryonic stem cells have the capacity to give rise to differentiated progeny representative of all three embryonic germ layers.", "Human embryonic stem cells give rise to cell types from the outer embryonic germ layer, but not the other two layers.", "Androgenetic haploid mouse embryonic stem cells (ESCs) can be derived and genetically manipulated in vitro.", "Cellular differentiation of embryonic stem cells is accompanied by changes in replication timing, transcription and nuclear localization.", "Specialized functional cell types can be derived from human pluripotent stem cells.", "Adult tissue-resident macrophages stem from the embryonal yolk sac and fetal liver.", "Adult tissue-resident macrophages stem from the embryonal yolk sac and fetal liver.", "Nuclear transfer from adult human fibroblasts to human oocytes can give rise to blastocysts containing expandable pluripotent cells.", "The myocardial cell lineage originally develops from cardiac progenitors of exclusively endodermal origin."], "hard_negative": "Human embryonic stem cells give rise to cell types from all three embryonic germ layers."}
{"query_id": "530", "query_text": "Human embryonic stem cells give rise to cell types from the outer embryonic germ layer, but not the other two layers.", "negative": "Intake of folic acid (FA) and vitamin B6 (VB6) reduces levels of homocysteine.", "negatives": ["Intake of folic acid (FA) and vitamin B6 (VB6) reduces levels of homocysteine.", "Glycan adaptation involves insertion-deletion events.", "Bacterial meningitis can be diagnosed on the basis of positive cerebrospinal fluid (CSF) cultures.", "Higher plasma levels of I-carnitine, when associated with trimethylamine N-oxide, are negatively correlated with cardiovascular events in humans.", "Walking in traffic areas in London did not improve lung function in elderly adults.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have increased risk for Alzheimer's disease.", "A deficiency of folate increases blood levels of homocysteine.", "The proportion of people with visual difficulty is two times higher in low-income countries than in high-income countries.", "PGE 2 suppresss intestinal tumor growth by altering the expression of tumor suppressing and DNA repair genes.", "Therapeutics receiving accelerated approval encounter a lower frequency of post-marketing safety events"], "hard_negatives": ["Human embryonic stem cells give rise to cell types from the outer embryonic germ layer, but not the other two layers.", "Human embryonic stem cells give rise to cell types from all three embryonic germ layers.", "Human embryonic stem cells have the capacity to give rise to differentiated progeny representative of all three embryonic germ layers.", "Cellular differentiation of embryonic stem cells is accompanied by changes in replication timing, transcription and nuclear localization.", "Androgenetic haploid mouse embryonic stem cells (ESCs) can be derived and genetically manipulated in vitro.", "Specialized functional cell types can be derived from human pluripotent stem cells.", "Adult tissue-resident macrophages stem from the embryonal yolk sac and fetal liver.", "Adult tissue-resident macrophages stem from the embryonal yolk sac and fetal liver.", "Nuclear transfer from adult human fibroblasts to human oocytes can give rise to blastocysts containing expandable pluripotent cells.", "Bone marrow cells don't contribute to adult macrophage compartments."], "hard_negative": "Human embryonic stem cells give rise to cell types from the outer embryonic germ layer, but not the other two layers."}
{"query_id": "531", "query_text": "Human embryonic stem cells have the capacity to give rise to differentiated progeny representative of all three embryonic germ layers.", "negative": "53% of perinatal mortality is due to low birth weight.", "negatives": ["53% of perinatal mortality is due to low birth weight.", "Citrullinated proteins externalized in neutrophil extracellular traps act indirectly to perpetuate the inflammatory cycle via induction of autoantibodies.", "Long - range chromatin interactions regulate transcription.", "The mean suicide rate in women is lower after miscarriage than live birth.", "Acute ablation of KRAS causes severe growth impairment.", "Surfactin producing cells and exopolymer producing cells cooperate to generate \"Van Gogh\" bundles that have sliding abilities on specialized media.", "Insulin effects appetite via ventral tegmental neurons.", "Ten percent (10%) of kidney cancers in the UK are attributable to excess weight.", "Chenodeoxycholic acid treatment decreases brown adipose tissue activity.", "Lack of FGF21 in mice leads to atherosclerotic plaque formation."], "hard_negatives": ["Human embryonic stem cells have the capacity to give rise to differentiated progeny representative of all three embryonic germ layers.", "Human embryonic stem cells give rise to cell types from all three embryonic germ layers.", "Human embryonic stem cells give rise to cell types from the outer embryonic germ layer, but not the other two layers.", "Androgenetic haploid mouse embryonic stem cells (ESCs) can be derived and genetically manipulated in vitro.", "Cellular differentiation of embryonic stem cells is accompanied by changes in replication timing, transcription and nuclear localization.", "Specialized functional cell types can be derived from human pluripotent stem cells.", "Nuclear transfer from adult human fibroblasts to human oocytes can give rise to blastocysts containing expandable pluripotent cells.", "Adult tissue-resident macrophages stem from the embryonal yolk sac and fetal liver.", "Adult tissue-resident macrophages stem from the embryonal yolk sac and fetal liver.", "The myocardial cell lineage originally develops from cardiac progenitors of exclusively endodermal origin."], "hard_negative": "Human embryonic stem cells have the capacity to give rise to differentiated progeny representative of all three embryonic germ layers."}
{"query_id": "537", "query_text": "Hypocretin neurones suppress panicprone state in rats.", "negative": "Increased mobility of retrotransposons does not lead to mutation and higher tumorigenesis rates.", "negatives": ["Increased mobility of retrotransposons does not lead to mutation and higher tumorigenesis rates.", "p16INK4A degradation is encoded by CDKN2A.", "Genes regulated by Esrrb transcription factor are sensitive to Mbd3 function.", "0-dimensional biomaterials lack inductive properties.", "Genetic deletion of JAM-A increases gut permeability.", "5'-nucleotidase metabolizes 6MP.", "Glucose restriction to 0.05% reduces RLS (replicative life span) by 20-40% in S. cerevisiae.", "Many transmembrane receptors transmit signals by long-range conformational changes in the association of alpha-helices across the plasma membrane.", "miRNAs regulate a unique suite of mRNAs to maintain homeostasis in cells.", "Increased purity of cytoplasmic membranes isolated from overexpressors is indicated by stronger spots for OmpF in 2D BN-PAGE gels."], "hard_negatives": ["Hypocretin neurones suppress panicprone state in rats.", "Patients with panic anxiety show decreased CSF levels of hypocretin.", "Pediatric SCD patients with vaso-occlusive crisis show increased morphine use after breathing 80 ppm iNO for 4 hours.", "Antidepressants increase the severity of migraines.", "Side effects associated with antidepressants increases risk of stroke.", "Side effects associated with antidepressants lower risk of myocardial infarction.", "Mice that lack Interferon-\u03b3 or its receptor are highly susceptible to experimental autoimmune myocarditis.", "Antidepressants reduce the severity of migraines.", "In patients with congenital heart defects, \u03b2-blockers significantly improve clinical heart failure outcomes.", "Hypothalamic glutamate neurotransmission is unrelated to energy balance."], "hard_negative": "Hypocretin neurones suppress panicprone state in rats."}
{"query_id": "541", "query_text": "Hypothalamic glutamate neurotransmission is unrelated to energy balance.", "negative": "Peroxynitrite is required for induction of T cell tolerance.", "negatives": ["Peroxynitrite is required for induction of T cell tolerance.", "A 100g dose of chloroquine chemoprophylactic regimen results in retinal toxicity after 5-6 years of weekly intake.", "In young and middle-aged adults, current or remote uses of ADHD medications increase the risk of serious cardiovascular events.", "In S. cerevisiae, the absence of RNA surveillance pathways reduces sensitivity to high iron conditions.", "Persister cells provide relapse resistance in cancer patients.", "Patients with common epithelial cancers  are more likely to have an emergency event as their first hospital admission if they live in resource-deprived areas.", "Enhanced early production of inflammatory chemokines damages viral control in the lung.", "MafA phosphorylation decreases its ubiquitination.", "Understanding epigenetic regulation of replication is essential for the reational design of episomally replicating vectors.", "MafA ubiquitination increases the recruitment of coavtivator P/CAF by MafA."], "hard_negatives": ["Hypothalamic glutamate neurotransmission is unrelated to energy balance.", "Energy balance requires hypothalamic glutamate neurotransmission.", "Insulin effects appetite via ventral tegmental neurons.", "Glial calcium waves influence seizures.", "Oxidative phosphorylation is one of the primary glycometabolic pathways in cells.", "Rhythmic expression of Cry1 translates directly into a circadian regulation of cAMP signaling in hepatic glucose metabolism.", "Occipital activation levels are associated with auditory spatial performance in parietal regions of the brain.", "Increased lipolysis leads to higher P38 phosphorylation in adipose tissue.", "Headaches are correlated with cognitive impairment.", "Reduced levels of lipolysis leads to higher P38 phosphorylation in adipose tissue."], "hard_negative": "Hypothalamic glutamate neurotransmission is unrelated to energy balance."}
{"query_id": "542", "query_text": "IFI16 impedes STING phosphorylation and translocation, resulting in reduced activation of STING.", "negative": "Lack of FGF21 in mice leads to atherosclerotic plaque formation.", "negatives": ["Lack of FGF21 in mice leads to atherosclerotic plaque formation.", "Ethanol stress increases the expression of PSP in bacteria.", "The repeat-variable diresidue (RVD) in the loop of Transcription-Activator Like (TAL) effectors specifies the nucleotides-amino acid contact at the target promoter element.", "TNFAIP3 is a glioblastoma tumor enhancer.", "Glycan adaptation involves insertion-deletion events.", "The risk of breast cancer among parous women decreases with placental weight of pregnancies.", "During non-homologous end joining, the ligation step is not as tolerant of disrepairs and other distortions when joining 3' of strand breaks as compared to 5' strand breaks.", "Microglia are an innate immune cell type of the peripheral nervous system.", "In domesticated populations of Saccharomyces cerevisiae, segmental aneuploidy occurs infrequently.", "Many cytokines that are produced by cancer cells also contribute to carcinogenesis."], "hard_negatives": ["IFI16 impedes STING phosphorylation and translocation, resulting in reduced activation of STING.", "Oxidative DNA damage inhibits STING signalling.", "Oxidative DNA damage activates STING signalling.", "KRT17 modulates the expression of the transcriptional regulator AIRE in diseased epithelia.", "p16INK4A degradation is  linked to an abnormal wound response caused by the microinvasive step of advanced Oral Potentially Malignant Lesions (OPMLs).", "ITAM phosphorylation allows for the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).", "Low expression of miR7a does not repress target genes or exert a biological function in testis.", "CDK6 shows impaired binding to loss-of-function variants of p18 INK4C.", "Deltex has no known interactions with eIF3f.", "JMJD6 catalyzes the hydroxylation of C-terminal lysine and supresses transcriptional activity."], "hard_negative": "IFI16 impedes STING phosphorylation and translocation, resulting in reduced activation of STING."}
{"query_id": "545", "query_text": "IFIT1 speeds viral replication by allowing for the proliferation of mis-capped viral RNAs.", "negative": "Treatment with a protein named FN restores regenerative abilities of aged muscles.", "negatives": ["Treatment with a protein named FN restores regenerative abilities of aged muscles.", "De novo assembly of sequence data has shorter contigs than unassembled sequence data.", "There was an estimated 30 million cases of pneumonia in young children worldwide in 2010.", "Upon viral challenge, influenza-specific memory CD4+ T cells greatly diminish the early production of inflammatory chemokines in the lung.", "Diminished ovarian reserve is a reliable indicator of infertility in a non-infertile population.", "MEK inhibitors are effective treatments in RAS-driven mouse models of cancer.", "An M2-like phenotype in brown adipose tissue macrophages is quickly induced by cold exposure.", "There is a relation between Erythromycin use and hypertrophic pyloric stenosis.", "Myelin sheaths play a role in action potential propagation.", "VgrG (Tssl) protein punctures membranes by forming a spike at the tip of the tube apparatus."], "hard_negatives": ["IFIT1 speeds viral replication by allowing for the proliferation of mis-capped viral RNAs.", "Mutations in RIM1 decrease levels of IME1 RNA.", "Mutations in RIM1 raise levels of IME1 RNA.", "Recognition of start codons depends on the translation initiation factor IF3.", "Genes involved in pre-mRNA splicing have a significant impact on genome stability.", "LSD1-positive promoters are associated with RNA polymerase II", "Pre-mRNAs associated with spliceosomal components are more stable than unassociated splicing substrates.", "Pre-mRNAs associated with spliceosomal components are less stable than unassociated splicing substrates.", "miRNAs regulate a unique suite of mRNAs to maintain homeostasis in cells.", "Understanding epigenetic regulation of replication is essential for the reational design of episomally replicating vectors."], "hard_negative": "IFIT1 speeds viral replication by allowing for the proliferation of mis-capped viral RNAs."}
{"query_id": "547", "query_text": "IL-10 production by monocytes inhibits CD4 + T cell response.", "negative": "Intake of folic acid (FA) and vitamin B6 (VB6) increases levels of homocysteine.", "negatives": ["Intake of folic acid (FA) and vitamin B6 (VB6) increases levels of homocysteine.", "Gastric infection with Helicobacter pylori increases risk of gastric cancer in humans.", "Deregulation of HAND2 is a crucial step in endometrial carcinogenesis in mice.", "Patients in stable partnerships have a slower progression from HIV to AIDS.", "Patients with common epithelial cancers  are more likely to have an emergency event as their first hospital admission if they live in resource-deprived areas.", "Cytosolic proteins bind to iron-responsive elements on mRNAs coding for TFRC1.", "Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection increases dissemination of Salmonella Typhimurium from the gut.", "Decreased conversion of PGE 2 to PPARy ligand 15-ket-PGE 2 causes accumulation of PGE.", "Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection increases dissemination of Salmonella Typhimurium from the gut.", "H4 G94P proteins inhibit chromatin assembly, which decreases free histones."], "hard_negatives": ["IL-10 production by monocytes inhibits CD4 + T cell response.", "PD-1 triggering on monocytes enhances IL-10 production by monocytes.", "CD28 signals regulate trafficking of murine auto-reactive T cells into target tissues.", "Reduced responsiveness to interleukin-2 in regulatory T cells is associated with autoimmune diseases such as Type 1 Diabetes.", "IL-6 signaling plays a major role in atherosclerotic cardiovascular disease.", "CD28 initiates tonic signaling in conventional T cells, which causes an exhaustion phenotype and limited efficiency.", "Major antigen-induced signals from the T cell receptor and secondary signals from costimulatory receptors are required for T cell activation.", "Egr2 regulates the homeostasis of B and T cells.", "Egr3 regulates the homeostasis of B and T cells.", "Type 1 Diabetes is associated with subtle perturbations in T reg development."], "hard_negative": "IL-10 production by monocytes inhibits CD4 + T cell response."}
{"query_id": "548", "query_text": "IL-6 signaling plays a major role in atherosclerotic cardiovascular disease.", "negative": "Varenicline monotherapy is more effective after 26 weeks of treatment compared to combination nicotine replacement therapies with varenicline or bupropion.", "negatives": ["Varenicline monotherapy is more effective after 26 weeks of treatment compared to combination nicotine replacement therapies with varenicline or bupropion.", "V-9302 inhibits antitumor responses by decreasing cell death and oxidative stress.", "Pioglitazone use is significantly associated with an increased risk of pancreatic cancer.", "Cnn1 recruitment varies with cell cycle timing.", "p16INK4A degradation is encoded by CDKN2A.", "Removal of H3K9me3 by ectopic expression of other H3K9 demethylases improves reprogramming efficiency in SCNT experiments.", "4-PBA treatment raises endoplasmic reticulum stress in response to general endoplasmic reticulum stress markers.", "Side effects associated with antidepressants lower risk of myocardial infarction.", "The RANK-RANK-Ligand (RANKL) pathway is involved in the development of Aire-expressing medullary thymic epithelial cells (mTECs).", "IFIT1 speeds viral replication by allowing for the proliferation of mis-capped viral RNAs."], "hard_negatives": ["IL-6 signaling plays a major role in atherosclerotic cardiovascular disease.", "IL-10 production by monocytes inhibits CD4 + T cell response.", "The minor G allele of FOXO3 up-regulates IL-10.", "Reduced responsiveness to interleukin-2 in regulatory T cells is associated with autoimmune diseases such as Type 1 Diabetes.", "Repressing IL-18 has negative effects on atherosclerotic lesion composition and progression.", "Interleukin-18 plays an important role in the pathogenesis of atherosclerosis.", "GATA3 regulates cell cycle progression in bone marrow hematopoietic stem cells.", "Toll-like receptor (TLR) signaling is involved in the pathogenesis of human MDS.", "PD-1 triggering on monocytes enhances IL-10 production by monocytes.", "LDL cholesterol has a causal role in the development of cardiovascular disease."], "hard_negative": "IL-6 signaling plays a major role in atherosclerotic cardiovascular disease."}
{"query_id": "550", "query_text": "ITAM phosphorylation allows for the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).", "negative": "The minor G allele of FOXO3 is related to less severe symptoms of Crohn's Disease.", "negatives": ["The minor G allele of FOXO3 is related to less severe symptoms of Crohn's Disease.", "CD28 initiates tonic signaling in conventional T cells, which causes an exhaustion phenotype and limited efficiency.", "Medications to treat obesity are highly effective.", "The proliferative capacity of progenitors is regulated cell-autonomously.", "Cellular differentiation of embryonic stem cells is accompanied by changes in replication timing, transcription and nuclear localization.", "Expression of oncolytic virus antigens as peptides makes relapse more likely.", "In melanoma, anti-CTLA-4 treatment reinvigorates exhausted PD-1+Eomes+CD8 T cells.", "Origin gross domestic product(GDP) is negatively related to dengue virus (DENV-1) diffusion in air traffic shipments.", "BiP is a general endoplasmic reticulum stress marker.", "Activated Cdk5 regulates DNA damage-induced neuronal death."], "hard_negatives": ["ITAM phosphorylation allows for the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).", "Major antigen-induced signals from the T cell receptor and secondary signals from costimulatory receptors are required for T cell activation.", "CD28 signals regulate trafficking of murine auto-reactive T cells into target tissues.", "T cell receptor /CD3 microdomains are required to induce the immunologic synapse.", "Foxp3 enables the expression of transcriptional regulators implicated in memory T cell development.", "Blocking the interaction between TDP-43 and respiratory complex I proteins ND3 and ND6 prevents TDP-43-induced neuronal loss.", "Foxp3 represses the expression of transcriptional regulators implicated in memory T cell development.", "B3-Galectin increases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR.", "Activated Cdk5 phosphorylates the ATM protein in response to DNA damage.", "B3-Galectin decreases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR."], "hard_negative": "ITAM phosphorylation allows for the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR)."}
{"query_id": "553", "query_text": "IgA plasma cells that are specific for transglutaminase 2 are scarce in the duodenal mucosa of celiac disease patients when the disease is active.", "negative": "M. stadtmanae induces ASC speck formation in BlaER1 monocytes.", "negatives": ["M. stadtmanae induces ASC speck formation in BlaER1 monocytes.", "Side effects associated with antidepressants increases risk of stroke.", "Dscam1 acts as a hypervariable pattern-recognition receptor for the immune system.", "p16INK4A degradation is  linked to an abnormal wound response caused by the microinvasive step of advanced Oral Potentially Malignant Lesions (OPMLs).", "Neutrophils produce IL-1\u03b2 in response to large particles.", "Charcoal shows no benefit for acute paraquat poisoning.", "Low expression of miR7a does not repress target genes or exert a biological function in ovaries.", "The minor G allele of FOXO3 is related to less severe symptoms of Crohn's Disease.", "The deamination of cytidine to uridine on the minus strand of viral DNA can inactivate the viral genome by inducing G-to-A mutations.", "Rhythmic expression of Cry1 translates directly into a circadian regulation of cAMP signaling in hepatic glucose metabolism."], "hard_negatives": ["IgA plasma cells that are specific for transglutaminase 2 are scarce in the duodenal mucosa of celiac disease patients when the disease is active.", "GATA3 regulates cell cycle progression in bone marrow hematopoietic stem cells.", "A T helper 2 cell (Th2) environment impedes disease development in patients with systemic lupus erythematosus (SLE).", "The composition of myosin-II isoform switches from the A isoform to the B isoform during hematopoietic differentiation.", "GATA3 regulates self-renewal capacity in bone marrow hematopoietic stem cells.", "Mice that lack Interferon-\u03b3 or its receptor are highly susceptible to experimental autoimmune myocarditis.", "Mutations in G-Beta protein GNB1 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.", "Chemical injury represses transglutaminase 2 activity.", "Mutant mice lacking SVCT2 have severely reduced ascorbic acid levels in both brain and adrenals.", "Gpr124 suppresses BBB breakdown in mouse models of ischemic stroke."], "hard_negative": "IgA plasma cells that are specific for transglutaminase 2 are scarce in the duodenal mucosa of celiac disease patients when the disease is active."}
{"query_id": "555", "query_text": "Immune complex triggered cell death leads to extracellular release of nuclear DNA.", "negative": "Osteocytes have an essential role in G-CSF induced HSPC mobilization.", "negatives": ["Osteocytes have an essential role in G-CSF induced HSPC mobilization.", "Surgical treatment is not superior to non-surgical in treating adults with displaced fractures of the proximal humerus.", "Anthrax spores are very difficult to dispose once they are dispersed.", "Individuals with low serum vitamin D concentrations have decreased risk of multiple sclerosis.", "TNFAIP3 is a tumor enhancer in glioblastoma.", "Intra-cerebroventricular infusion of amyloid-\u03b2 oligomers increases expression of fibronectin type-III domain-containing protein 5 mRNA in mice hippocampi.", "Patients with panic anxiety show decreased CSF levels of hypocretin.", "H.pylori-mediated gastric cancer occurs due to the accumulation of mutations in host epithelial cells.", "There is no relation between Erythromycin use and hypertrophic pyloric stenosis.", "Stacking is more stable when a purine is present in the +5 position (C1698)."], "hard_negatives": ["Immune complex triggered cell death leads to extracellular release of nuclear DNA.", "Immune complex triggered cell death leads to sequestration of oxidized mitochondrial DNA.", "Oxidative DNA damage activates STING signalling.", "The deamination of cytidine to uridine on the minus strand of viral DNA can inactivate the viral genome by inducing G-to-A mutations.", "Cellular differentiation of embryonic stem cells is accompanied by changes in replication timing, transcription and nuclear localization.", "Nuclear transfer from adult human fibroblasts to human oocytes can give rise to blastocysts containing expandable pluripotent cells.", "Mitochondria play a major role in apoptosis.", "Activated Cdk5 regulates DNA damage-induced neuronal death.", "Oxidative DNA damage inhibits STING signalling.", "Neutrophils produce IL-1\u03b2 in response to large particles."], "hard_negative": "Immune complex triggered cell death leads to extracellular release of nuclear DNA."}
{"query_id": "557", "query_text": "Immune complex triggered cell death leads to sequestration of oxidized mitochondrial DNA.", "negative": "B3-Galectin increases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR.", "negatives": ["B3-Galectin increases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR.", "Therapeutics receiving accelerated approval encounter a lower frequency of post-marketing safety events", "The risk of breast cancer among parous women decreases with placental weight of pregnancies.", "Incidence of heart failure increased by 10% in women since 1979.", "Individuals with low serum vitamin D concentrations have decreased risk of multiple sclerosis.", "Reduced responsiveness to interleukin-2 in regulatory T cells is associated with autoimmune diseases such as Type 1 Diabetes.", "Immune responses in immune cells are geographically segregated.", "Replacement of OCT4 and SOX2 genes with GATA3 is not capable of reprogramming human cells.", "A 100g dose of chloroquine chemoprophylactic regimen results in retinal toxicity after 1 year of weekly intake.", "Microcin J25 encourages nucleoside triphosphate (NTP) binding."], "hard_negatives": ["Immune complex triggered cell death leads to sequestration of oxidized mitochondrial DNA.", "Immune complex triggered cell death leads to extracellular release of nuclear DNA.", "Cytochrome c is transferred from cytosol to the mitochondrial intermembrane space during apoptosis.", "The deamination of cytidine to uridine on the minus strand of viral DNA can inactivate the viral genome by inducing G-to-A mutations.", "Elevated cell-free mitochondrial DNA levels are associated with mortality.", "Oxidative DNA damage activates STING signalling.", "Oxidative DNA damage inhibits STING signalling.", "Neutrophils produce IL-1\u03b2 in response to large particles.", "Mitochondria play a major role in energy production.", "The generation of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells."], "hard_negative": "Immune complex triggered cell death leads to sequestration of oxidized mitochondrial DNA."}
{"query_id": "559", "query_text": "Immune responses in immune cells are geographically segregated.", "negative": "IFIT1 speeds viral replication by allowing for the proliferation of mis-capped viral RNAs.", "negatives": ["IFIT1 speeds viral replication by allowing for the proliferation of mis-capped viral RNAs.", "The cytokine receptor which regulates chemotaxis and formation of lymph nodes is involved in production of myeloperoxidase in the left atrium.", "Genomic sequences involved in alternative splicing responsible for Hutchinson-Gilford progeria syndrome (HGPS) are abundant in the ''progerinonly'' allele of Lmna knock-in models.", "ITAM phosphorylation allows for the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).", "Activator-inhibitor pairs are provided ventrally by Xrl-sizzled.", "Incidence of 10/66 dementia is lower than the incidence of DSM-IV dementia.", "Folate and vitamin B12 levels influence the association between homocysteine and preeclampsia.", "Cost effectiveness evaluations based on cRCT data accurately reflect prices for patients in actual clinical practice.", "G-CSF increases the expansion and infiltration of MDSCs into tumors.", "Environmentally-induced senescence is mimicked in disease modeling by adding specific molecules to the culture system."], "hard_negatives": ["Immune responses in immune cells are geographically segregated.", "Microglia are an innate immune cell type of the central nervous system.", "The innate immune response struggles to remove small numbers of parasites.", "Microglia are an innate immune cell type of the peripheral nervous system.", "Mitochondria play a major role in energy production.", "Tuberculosis-induced granulomas express different immune system protein signatures than the surrounding tissue.", "The proliferative capacity of neural progenitors differs across species.", "Increased flux of microbial products provokes immune responses.", "Increased flux of microbial products suppresses immune responses.", "The tissue surrounding the granuloma in an immune cell induces an anti-inflammatory immune response."], "hard_negative": "Immune responses in immune cells are geographically segregated."}
{"query_id": "562", "query_text": "Improvements in OER catalysts show stable activity over several hundred hours.", "negative": "Mice that lack Interferon-\u03b3 or its receptor are highly susceptible to experimental autoimmune myocarditis.", "negatives": ["Mice that lack Interferon-\u03b3 or its receptor are highly susceptible to experimental autoimmune myocarditis.", "Oxidative DNA damage activates STING signalling.", "The most prevalent adverse events to Semaglutide are cardiovascular.", "Mutations in RIM1 raise levels of IME1 RNA.", "Tirasemtiv targets cardiac muscle.", "Diabetes remission occurs less in people treated with conventional therapy than in people treated with laparoscopic adjustable gastric banding surgery.", "90% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.", "Upregulation of PD1 causes the upregulation of Satb1.", "Bariatric surgery leads to positive outcomes in mental health.", "Peroxynitrite is required for induction of T cell tolerance."], "hard_negatives": ["Improvements in OER catalysts show stable activity over several hundred hours.", "Rapid phosphotransfer rates are correlated with histidine kinase regulator specificity.", "Glucose restriction to 0.05% reduces RLS (replicative life span) by 20-40% in S. cerevisiae.", "Replacement of histone H2A with H2A.Z accelerates gene activation in yeasts by destabilizing +1 nucleosomes.", "Active H. pylori urease has a polymeric structure consisting of five distinct subunits.", "Increased conversion of PGE 2 to PPARy ligand 15-ket-PGE 2 causes accumulation of PGE.", "Mitochondria play a major role in energy production.", "Oxidative phosphorylation is one of the primary glycometabolic pathways in cells.", "The ability of activator E2Fs in preventing cell death is limited to terminally differentiated cells.", "Decreased conversion of PGE 2 to PPARy ligand 15-ket-PGE 2 causes accumulation of PGE."], "hard_negative": "Improvements in OER catalysts show stable activity over several hundred hours."}
{"query_id": "563", "query_text": "In British Men, haplogroup I decreases risk of cardiovascular disease.", "negative": "Taxation of sugar-sweetened beverages reduced the incidence rate of type II diabetes in India.", "negatives": ["Taxation of sugar-sweetened beverages reduced the incidence rate of type II diabetes in India.", "Removal of H3K9me3 improves reprogramming efficiency in human somatic cell nuclear transfer experiments.", "61% of colorectal cancer patients are diagnosed with regional or distant metastases.", "Rapamycin delays aging in fruit flies.", "RANK-RANKL pathway signalling has no known association with development of Aire-expressing medullary thymic epithelial cells.", "Ca2+ cycling controls whole-body energy homeostasis in beige fat.", "Genes involved in pre-mRNA splicing have a significant impact on genome stability.", "Decrease of p62 in prostate tumor stroma results in defective autophagy.", "Varenicline monotherapy is more effective after 26 weeks of treatment compared to combination nicotine replacement therapies with varenicline or bupropion.", "Elevated cell-free mitochondrial DNA levels are associated with mortality."], "hard_negatives": ["In British Men, haplogroup I increases risk of cardiovascular disease by 50%.", "In British Men, haplogroup I decreases risk of cardiovascular disease.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have decreased risk for dementia.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have increased risk for Alzheimer's disease.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have longer lifetime exposure to estrogen due to an increased reproductive period.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have shorter lifetime exposure to estrogen due to a decreased reproductive period.", "Ten percent (10%) of kidney cancers in the UK are attributable to excess weight.", "A mutation in HNF4A leads to an increased risk of diabetes by the age of 14 years.", "A mutation in HNF4A leads to an increased risk of developing diabetes by the age of 14 years.", "Women with a lower birth weight are more likely to develop breast cancer later in life."], "hard_negative": "In British Men, haplogroup I increases risk of cardiovascular disease by 50%."}
{"query_id": "564", "query_text": "In British Men, haplogroup I increases risk of cardiovascular disease by 50%.", "negative": "BiP is a general endoplasmic reticulum stress marker.", "negatives": ["BiP is a general endoplasmic reticulum stress marker.", "HbA1c consistently overestimates glycemic control in black individuals with Sickle cell trait (SCT).", "In pediatric tissue, most T cells are naive T cell emigrants from the thymus.", "Bariatric surgery reduces colorectal cancer.", "In a naive state, blocking Wingless-Int-1 secretion from mouse embryonic stem cells inhibits self-renewal of the mouse embryonic stem cells.", "DUSP4 decreases apoptosis.", "PKG-la does not have a large impact on expression of spinal long term potentiation in PGK-la knockout mice.", "Commelina yellow mottle virus' (ComYMV) genome consists of 2140 baise pairs.", "Pioglitazone use is significantly associated with an increased risk of prostate cancer.", "Fibroblast Growth Factor is a ligand which signals through receptor tyrosine kinases."], "hard_negatives": ["In British Men, haplogroup I increases risk of cardiovascular disease by 50%.", "In British Men, haplogroup I decreases risk of cardiovascular disease.", "Ten percent (10%) of kidney cancers in the UK are attributable to excess weight.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have decreased risk for dementia.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have increased risk for Alzheimer's disease.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have longer lifetime exposure to estrogen due to an increased reproductive period.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have shorter lifetime exposure to estrogen due to a decreased reproductive period.", "Systemic lupus erythematosus is a risk factor for cardiovascular disease.", "A mutation in HNF4A leads to an increased risk of diabetes by the age of 14 years.", "A mutation in HNF4A leads to an increased risk of developing diabetes by the age of 14 years."], "hard_negative": "In British Men, haplogroup I increases risk of cardiovascular disease by 50%."}
{"query_id": "565", "query_text": "In S. cerevisiae, the absence of RNA surveillance pathways causes sensitivity to high iron conditions.", "negative": "Gastric infection with Helicobacter pylori increases risk of gastric cancer in humans.", "negatives": ["Gastric infection with Helicobacter pylori increases risk of gastric cancer in humans.", "Up-regulation of the p53 pathway and related molecular events speeds cancer progression.", "DMS3 protein enables Pol V transcription in vivo.", "In patients with congenital heart defects, \u03b2-blockers significantly improve clinical heart failure outcomes.", "Expression of oncolytic virus antigens as peptides makes relapse more likely.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have decreased risk for dementia.", "Migraine with aura is associated with ischemic stroke.", "IgA plasma cells that are specific for transglutaminase 2 are scarce in the duodenal mucosa of celiac disease patients when the disease is active.", "Including pharmacists in rounding teams reduces the incidence of adverse drug events (ADEs).", "Egr2 regulates the homeostasis of B and T cells."], "hard_negatives": ["In S. cerevisiae, the absence of RNA surveillance pathways causes sensitivity to high iron conditions.", "In S. cerevisiae, the absence of RNA surveillance pathways reduces sensitivity to high iron conditions.", "Cytosolic proteins bind to iron-responsive elements on mRNAs coding for TFRC1.", "Mitochondria play a trivial role in calcium homeostasis.", "A strong bias in the phage genome locations where the spacers were derived has been observed in many CRISPR subtypes that confer the immunity to phage.", "The ability of activator E2Fs in preventing cell death is limited to terminally differentiated cells.", "Higher plasma levels of I-carnitine, when associated with trimethylamine N-oxide, are negatively correlated with cardiovascular events in humans.", "Higher plasma levels of I-carnitine, when associated with trimethylamine N-oxide, are positively correlated with cardiovascular events in humans.", "Mitochondria play a major role in energy production.", "Ethanol stress increases the expression of IBP in bacteria."], "hard_negative": "In S. cerevisiae, the absence of RNA surveillance pathways causes sensitivity to high iron conditions."}
{"query_id": "566", "query_text": "In S. cerevisiae, the absence of RNA surveillance pathways reduces sensitivity to high iron conditions.", "negative": "Increased microtubule acetylation repairs interference of axonal transport caused by LRRK2 Roc-COR domain mutations.", "negatives": ["Increased microtubule acetylation repairs interference of axonal transport caused by LRRK2 Roc-COR domain mutations.", "The risk of breast cancer among parous women decreases with placental weight of pregnancies.", "Omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegans.", "Rhythmic expression of Cry1 translates directly into a circadian regulation of cAMP signaling in hepatic glucose metabolism.", "Major vault protein regulates sorting of tumor suppressive miR-193a into EVs.", "Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection increases dissemination of Salmonella Typhimurium from the gut.", "Increased vessel density along with a reduction in fibrosis improves the efficacy of chemotherapy treatments.", "Tumor development occurs in conjunction with suppression of pro-inflammatory cytokines.", "Polymeal nutrition increases cardiovascular mortality.", "The mean suicide rate in women is higher after miscarriage than live birth."], "hard_negatives": ["In S. cerevisiae, the absence of RNA surveillance pathways reduces sensitivity to high iron conditions.", "In S. cerevisiae, the absence of RNA surveillance pathways causes sensitivity to high iron conditions.", "Cytosolic proteins bind to iron-responsive elements on mRNAs coding for TFRC1.", "Higher plasma levels of I-carnitine, when associated with trimethylamine N-oxide, are negatively correlated with cardiovascular events in humans.", "A strong bias in the phage genome locations where the spacers were derived has been observed in many CRISPR subtypes that confer the immunity to phage.", "Higher plasma levels of I-carnitine, when associated with trimethylamine N-oxide, are positively correlated with cardiovascular events in humans.", "The ability of activator E2Fs in preventing cell death is limited to terminally differentiated cells.", "Mitochondria play a trivial role in calcium homeostasis.", "Ethanol stress increases the expression of IBP in bacteria.", "A deficiency of folate increases blood levels of homocysteine."], "hard_negative": "In S. cerevisiae, the absence of RNA surveillance pathways reduces sensitivity to high iron conditions."}
{"query_id": "568", "query_text": "In a naive state, blocking Wingless-Int-1 secretion from mouse embryonic stem cells inhibits self-renewal of the mouse embryonic stem cells.", "negative": "MafA ubiquitination decreases the recruitment of coavtivator P/CAF by MafA.", "negatives": ["MafA ubiquitination decreases the recruitment of coavtivator P/CAF by MafA.", "Distant CREs are important for transcriptional regulation.", "Tumor development occurs in conjunction with suppression of pro-inflammatory cytokines.", "Chinese individuals with TT homozygosity in the MTHFR gene are more vulnerable to strokes caused by low levels of folate intake.", "H4 G94P proteins inhibit chromatin assembly, which decreases free histones.", "The number of unfertilized oocytes in mated hermaphrodites increases with age.", "Mice defective for deoxyribonucleic acid (DNA) polymerase m (polm) reveal increased sensitivity to ionizing radiation (IR).", "Mutations in RIM1 decrease levels of IME1 RNA.", "Activated Cdk5 phosphorylates the ATM protein in response to DNA damage.", "Increased LDL receptors plays a role in the reduction of plasma Lp(a)."], "hard_negatives": ["In a naive state, blocking Wingless-Int-1 secretion from mouse embryonic stem cells inhibits self-renewal of the mouse embryonic stem cells.", "Androgenetic haploid mouse embryonic stem cells (ESCs) can be derived and genetically manipulated in vitro.", "Human embryonic stem cells give rise to cell types from the outer embryonic germ layer, but not the other two layers.", "Cellular differentiation of embryonic stem cells is accompanied by changes in replication timing, transcription and nuclear localization.", "Human embryonic stem cells have the capacity to give rise to differentiated progeny representative of all three embryonic germ layers.", "Reducing H3k4me3 methylation induces mouse epiblast stem cells to naive pluripotency efficiently.", "Activation of the Rac1 homolog CED-10 kills viable cells in SRGP-1 mutant Caenorhabditis elegans.", "Human embryonic stem cells give rise to cell types from all three embryonic germ layers.", "Foxp3 enables the expression of transcriptional regulators implicated in memory T cell development.", "Lack of FGF21 in mice increases life expectancy."], "hard_negative": "In a naive state, blocking Wingless-Int-1 secretion from mouse embryonic stem cells inhibits self-renewal of the mouse embryonic stem cells."}
{"query_id": "570", "query_text": "In breast cancer, the loss of myoepithelial cells promotes the transition of ductal carcinoma in situ to invasive carcinoma.", "negative": "Ethanol stress increases the expression of SRL in bacteria.", "negatives": ["Ethanol stress increases the expression of SRL in bacteria.", "PRC1-bound plasmids sediment at a slower rate in unbound plasmids than in sucrose gradients.", "Active H. pylori urease has a polymeric structure consisting of five distinct subunits.", "Lack of FGF21 in mice leads to reduced lifespan.", "In melanoma, anti-CTLA-4 treatment reinvigorates exhausted PD-1+Eomes+CD8 T cells.", "Forkhead 0 (fox0) transcription factors are involved in cellular differentiation.", "Pseudogene PTENP1 encodes a transcript that regulates PTEN expression.", "Over half of the gabonese children with Schimmelpenning-Feuerstein-Mims syndrome (SFM) had a plasma lactate of more than 5mmol/L.", "Destination container port throughput(CPT) is negatively related to dengue virus (DENV-1) diffusion in air traffic shipments.", "De novo assembly of sequence data has shorter contigs than unassembled sequence data."], "hard_negatives": ["In breast cancer, the loss of myoepithelial cells promotes the transition of ductal carcinoma in situ to invasive carcinoma.", "In breast cancer, the loss of myoepithelial cells slows the transition of ductal carcinoma in situ to invasive carcinoma.", "Many cytokines that are produced by cancer cells also contribute to carcinogenesis.", "Cancer-associated fibroblasts (CAFs) interact with cancer cells to mediate formation and activation of CAFs.", "Environmental factors can influence the development of breast cancer.", "Cancer-associated fibroblasts (CAFs) have no known interaction with cancer cells in the formation and activation of CAFs.", "The risk of breast cancer among parous women decreases with placental weight of pregnancies.", "Ten percent (10%) of kidney cancers in the UK are attributable to excess weight.", "H.pylori-mediated gastric cancer occurs due to the accumulation of mutations in host epithelial cells.", "Women with a lower birth weight are more likely to develop breast cancer later in life."], "hard_negative": "In breast cancer, the loss of myoepithelial cells promotes the transition of ductal carcinoma in situ to invasive carcinoma."}
{"query_id": "571", "query_text": "In breast cancer, the loss of myoepithelial cells slows the transition of ductal carcinoma in situ to invasive carcinoma.", "negative": "HOXB4 is a highly expressed component of cellular secretome from fetal liver cell populations.", "negatives": ["HOXB4 is a highly expressed component of cellular secretome from fetal liver cell populations.", "Malaria has a high vectorial capacity.", "IFI16 impedes STING phosphorylation and translocation, resulting in reduced activation of STING.", "Blocking the interaction between TDP-43 and respiratory complex I proteins ND3 and ND6 prevents TDP-43-induced neuronal loss.", "HOXB4 is a highly expressed component of cellular secretome from fetal liver cell populations.", "Deltex has no known interactions with eIF3f.", "Nuclear transfer from adult human fibroblasts to human oocytes can give rise to blastocysts containing expandable pluripotent cells.", "Klf4 is not required for proper myeloid cell differentiation.", "Differentiation of progenitor cells to myeloid cells is skewed upon activation of insulin signaling.", "Tuberculosis incidence occurs at higher rates in more sparsely populated areas in the UK."], "hard_negatives": ["In breast cancer, the loss of myoepithelial cells slows the transition of ductal carcinoma in situ to invasive carcinoma.", "In breast cancer, the loss of myoepithelial cells promotes the transition of ductal carcinoma in situ to invasive carcinoma.", "Environmental factors can influence the development of breast cancer.", "Cancer-associated fibroblasts (CAFs) have no known interaction with cancer cells in the formation and activation of CAFs.", "Many cytokines that are produced by cancer cells also contribute to carcinogenesis.", "Cancer-associated fibroblasts (CAFs) interact with cancer cells to mediate formation and activation of CAFs.", "H.pylori-mediated gastric cancer occurs due to the accumulation of mutations in host epithelial cells.", "The risk of breast cancer among parous women decreases with placental weight of pregnancies.", "Cancer-associated fibroblasts (CAFs) are constituents of tumor microenvironments", "Cancer cells can stimulate the accumulation of intra-tumoural myeloid-derived suppressor cells by promoting granulocyte colony stimulating factor production."], "hard_negative": "In breast cancer, the loss of myoepithelial cells slows the transition of ductal carcinoma in situ to invasive carcinoma."}
{"query_id": "572", "query_text": "In chronic viral infections or tumors, peptides that selectively inhibit PTPRS can be utilized to boost insufficient activity of pDCs.", "negative": "G-CSF increases the expansion and infiltration of MDSCs into tumors.", "negatives": ["G-CSF increases the expansion and infiltration of MDSCs into tumors.", "A 100g dose of chloroquine chemoprophylactic regimen results in retinal toxicity after 5-6 years of weekly intake.", "Radioiodine treatment of non-toxic multinodular goitre increases thyroid volume.", "Removal of H3K9me3 improves reprogramming efficiency in human somatic cell nuclear transfer experiments.", "CDK6 shows improved binding to loss-of-function variants of p18 INK4C.", "Reduced phosphorylation of PP2A suppresses HDAC4 dephosphorylation.", "Diabetes remission occurs more in people treated with conventional therapy than in people treated with laparoscopic adjustable gastric banding surgery.", "Egr3 regulates the homeostasis of B and T cells.", "Lysine histone demethylase inhibitor JIB 04 is inactive against KDM5A.", "AZT given with ribavirin increases anemia."], "hard_negatives": ["In chronic viral infections or tumors, peptides that selectively inhibit PTPRS can be utilized to boost insufficient activity of pDCs.", "PCSK9 inhibitors decrease plasma Lp(a) levels.", "CD28 signals regulate trafficking of murine auto-reactive T cells into target tissues.", "Activation of PPM1D enhances p53 function.", "In melanoma, anti-CTLA-4 treatment reinvigorates exhausted PD-1+Eomes+CD8 T cells.", "Major antigen-induced signals from the T cell receptor and secondary signals from costimulatory receptors are required for T cell activation.", "The PDPN gene deactivates the C-type lectin receptor (CLEC-2).", "Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes fibrosis.", "Upregulation of PD1 causes the downmodulation of Satb1.", "ITAM phosphorylation allows for the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR)."], "hard_negative": "In chronic viral infections or tumors, peptides that selectively inhibit PTPRS can be utilized to boost insufficient activity of pDCs."}
{"query_id": "573", "query_text": "In domesticated populations of Saccharomyces cerevisiae, segmental aneuploidy is very common.", "negative": "Urbanization is an important risk factor related to the transmission of dengue fever.", "negatives": ["Urbanization is an important risk factor related to the transmission of dengue fever.", "TNFAIP3 is a glioblastoma tumor suppressor.", "Including pharmacists in rounding teams does not alter the incidence of adverse drug events (ADEs).", "Origin gross domestic product(GDP) is negatively related to dengue virus (DENV-1) diffusion in air traffic shipments.", "Inhibiting glucose-6-phospate dehydrogenase improves lipogenesis by deactivating LKB1-AMPK signaling.", "Helminths interfere with immune system control of coinfections by microbial pathogens 16.", "Women with a lower birth weight are more likely to develop breast cancer later in life.", "In rhesus macaques, daily subcutaneous injections of tenofovir protects against rectally transmitted simian-human immunodeficiency virus.", "Tonic signaling from the scFv is amplified by MyD88/CD40.", "ATM and Rad3 related protein have no role in sensing DNA damage."], "hard_negatives": ["In domesticated populations of Saccharomyces cerevisiae, segmental aneuploidy is very common.", "In domesticated populations of Saccharomyces cerevisiae, segmental aneuploidy occurs infrequently.", "Crossover hot spots are found within gene promoters in Saccharomyces cerevisiae.", "Inside the body, falciparum parasites reproduce asexually.", "Human embryonic stem cells have the capacity to give rise to differentiated progeny representative of all three embryonic germ layers.", "Human embryonic stem cells give rise to cell types from the outer embryonic germ layer, but not the other two layers.", "A strong bias in the phage genome locations where the spacers were derived has been observed in many CRISPR subtypes that confer the immunity to phage.", "Adult tissue-resident macrophages are seeded before birth.", "Adult tissue-resident macrophages are seeded before birth.", "Adult tissue-resident macrophages stem from the embryonal yolk sac and fetal liver."], "hard_negative": "In domesticated populations of Saccharomyces cerevisiae, segmental aneuploidy is very common."}
{"query_id": "574", "query_text": "In domesticated populations of Saccharomyces cerevisiae, segmental aneuploidy occurs infrequently.", "negative": "Scapular stabilizer exercises are more effective than general exercise therapy in reducing pain and improving function of the shoulder.", "negatives": ["Scapular stabilizer exercises are more effective than general exercise therapy in reducing pain and improving function of the shoulder.", "Systemic lupus erythematosus is a risk factor for cardiovascular disease.", "MafA phosphorylation enhances its ubiquitination.", "L3MBTL2 binds to H2AK119Ub marked chromatin to form a PRC1 complex.", "Kir7.1 modulates channel activity by the G protein-coupled melanocortin-4 receptor (MC4R) in the paraventricular nucleus of the hypothalamus.", "PD-1 triggering on monocytes enhances IL-10 production by monocytes.", "Adult tissue-resident macrophages are seeded before birth.", "Metastatic colorectal cancer treated with a single agent fluoropyrimidines resulted in similar efficacy and better quality of life when compared with oxaliplatin-based chemotherapy in elderly patients.", "The NF-\u03baB essential modulator gene prevents intestinal inflammation by inhibiting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death.", "MT binding domain drives amyloid structure formation."], "hard_negatives": ["In domesticated populations of Saccharomyces cerevisiae, segmental aneuploidy occurs infrequently.", "In domesticated populations of Saccharomyces cerevisiae, segmental aneuploidy is very common.", "Crossover hot spots are found within gene promoters in Saccharomyces cerevisiae.", "Inside the body, falciparum parasites reproduce asexually.", "Adult tissue-resident macrophages are seeded before birth.", "Adult tissue-resident macrophages are seeded before birth.", "Adult tissue-resident macrophages stem from the embryonal yolk sac and fetal liver.", "Adult tissue-resident macrophages stem from the embryonal yolk sac and fetal liver.", "A strong bias in the phage genome locations where the spacers were derived has been observed in many CRISPR subtypes that confer the immunity to phage.", "The latent infection of myeloid cells with human cytomegalovirus induces a number of changes in gene expression."], "hard_negative": "In domesticated populations of Saccharomyces cerevisiae, segmental aneuploidy occurs infrequently."}
{"query_id": "576", "query_text": "In melanoma, anti-CTLA-4 treatment reinvigorates exhausted PD-1+Eomes+CD8 T cells.", "negative": "IgA plasma cells that are specific for transglutaminase 2 are scarce in the duodenal mucosa of celiac disease patients when the disease is active.", "negatives": ["IgA plasma cells that are specific for transglutaminase 2 are scarce in the duodenal mucosa of celiac disease patients when the disease is active.", "PRC1-bound plasmids sediment at a slower rate in unbound plasmids than in sucrose gradients.", "There is no known interaction between Pioneer factor OCT3/4 and major chromatin remodeling factors.", "p75 NTR - associated cell death executor (NADE) interacts with the p75 NTR death domain", "Ly49Q directs the organization of neutrophil polarization by regulating membrane raft functions.", "In breast cancer, the loss of myoepithelial cells slows the transition of ductal carcinoma in situ to invasive carcinoma.", "The risk of cancer rises with level of alcohol consumption.", "Mitochondria play a major role in apoptosis.", "Chlamydia trachomatis is most prevalent in the UK among individuals in their 50s and 60s.", "\u03b21/Ketel is able to bind microtubules."], "hard_negatives": ["In melanoma, anti-CTLA-4 treatment reinvigorates exhausted PD-1+Eomes+CD8 T cells.", "90% of patients with melanoma and an objective response to PD-1 blockade will experience a progression in their melanoma.", "CD28 initiates tonic signaling in conventional T cells, which causes an exhaustion phenotype and limited efficiency.", "PCSK9 inhibitors decrease plasma Lp(a) levels.", "LRBA prevents CTLA - 4 recycling.", "PD-1 triggering on monocytes enhances IL-10 production by monocytes.", "EG7 tumors can be killed by systemic oxaliplatin primed CD8+ T cells from the tumor-draining lymph node cells.", "LRBA promotes CTLA - 4 recycling.", "Antiretroviral therapy increases rates of tuberculosis across a broad range of CD4 strata.", "HSCT-T dosage may not be diagnostic if the onset of symptoms occurs less than 3 hours before AMI."], "hard_negative": "In melanoma, anti-CTLA-4 treatment reinvigorates exhausted PD-1+Eomes+CD8 T cells."}
{"query_id": "579", "query_text": "In patients with congenital heart defects, \u03b2-blockers significantly improve clinical heart failure outcomes.", "negative": "Incidence of 10/66 dementia is higher than the incidence of DSM-IV dementia.", "negatives": ["Incidence of 10/66 dementia is higher than the incidence of DSM-IV dementia.", "Glucose restriction to 0.05% reduces RLS (replicative life span) by 20-40% in S. cerevisiae.", "Surgical treatment is not superior to non-surgical in treating adults with displaced fractures of the proximal humerus.", "Reduction of purity of cytoplasmic membranes isolated from overexpressors is indicated by stronger spots for OmpA in 2D BN-PAGE gels.", "PD-1 triggering on monocytes enhances IL-10 production by monocytes.", "Transcription factor EB induces transcription of pro-inflammatory cytokines in macrophages infected with Staphylococcus aureus.", "Incidence of 10/66 dementia is higher than the incidence of DSM-IV dementia.", "The PRDM1 gene, when combined with the PRDM14 gene, plays an important role during primordial germ cell specification.", "Increased mobility of retrotransposons is assosciated with mutation and higher tumorigenesis rates.", "Increased LDL receptors plays a role in the reduction of plasma Lp(a)."], "hard_negatives": ["In patients with congenital heart defects, \u03b2-blockers significantly improve clinical heart failure outcomes.", "Side effects associated with antidepressants increases risk of stroke.", "Taking anti-depresents is associated with a decrease in the A\u03b2 level in the brain of experimental animals.", "Side effects associated with antidepressants lower risk of myocardial infarction.", "In young and middle-aged adults, current or remote uses of ADHD medications increase the risk of serious cardiovascular events.", "Sildenafil worsens erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.", "Mice that lack Interferon-\u03b3 or its receptor are highly susceptible to experimental autoimmune myocarditis.", "Sudden death can occur in patients with orthostatic hypertension without cardiac conduction abnormalities.", "Antidepressants reduce the severity of migraines.", "Side effects associated with antidepressants do not represent a mortality risk to postmenopausal women."], "hard_negative": "In patients with congenital heart defects, \u03b2-blockers significantly improve clinical heart failure outcomes."}
{"query_id": "580", "query_text": "In pediatric tissue, most T cells are naive T cell emigrants from the thymus.", "negative": "N348I mutations reduce resistance to nevirapine.", "negatives": ["N348I mutations reduce resistance to nevirapine.", "miRNAs enforce homeostasis by suppressing low-level ''leaky'' transcription.", "The risk of cancer rises with level of alcohol consumption.", "Genomic aberrations of metastases provide information for targeted therapy.", "Eilat virus (EILV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in nonhuman primates.", "Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes epithelial damage.", "Activation of the Rac1 homolog CED-10 kills viable cells in SRGP-1 mutant Caenorhabditis elegans.", "4-PBA treatment raises endoplasmic reticulum stress in response to general endoplasmic reticulum stress markers.", "The proliferative capacity of neural progenitors differs across species.", "B cells go though plasmablast differentiation and antibody production by continuous expression of EBI2."], "hard_negatives": ["In pediatric tissue, most T cells are naive T cell emigrants from the thymus.", "Approximately 250,000 people are infected with human T-cell lymphotropic virus type 1 in the United Kingdom.", "Major antigen-induced signals from the T cell receptor and secondary signals from costimulatory receptors are required for T cell activation.", "Type 1 Diabetes is associated with subtle perturbations in T reg development.", "CD28 signals regulate trafficking of murine auto-reactive T cells into target tissues.", "Lice attenuated SIV vaccines induce a stronger antigen-specific T cell response in lymph node cells.", "Reduced responsiveness to interleukin-2 in regulatory T cells is associated with autoimmune diseases such as Type 1 Diabetes.", "Androgenetic haploid mouse embryonic stem cells (ESCs) can be derived and genetically manipulated in vitro.", "EG7 tumors can be killed by systemic oxaliplatin primed CD8+ T cells from the tumor-draining lymph node cells.", "A T helper 2 cell (Th2) environment impedes disease development in patients with systemic lupus erythematosus (SLE)."], "hard_negative": "In pediatric tissue, most T cells are naive T cell emigrants from the thymus."}
{"query_id": "582", "query_text": "In rhesus macaques, daily subcutaneous injections of emtricitabine are ineffective at protecting against rectally transmitted simian-human immunodeficiency virus.", "negative": "ScPif1p has reduced binding ability to G-rich ssDNA compared to non-G-rich ssDNA.", "negatives": ["ScPif1p has reduced binding ability to G-rich ssDNA compared to non-G-rich ssDNA.", "Epidemiological disease burden from noncommunicable diseases is more prevalent in high economic settings.", "Insulin decreases risk of severe kidney failure.", "Upon viral challenge, influenza-specific memory CD4+ T cells greatly diminish the early production of inflammatory chemokines in the lung.", "The DESMOND program demonstrates no significant impact on biochemical outcomes.", "The risk of cancer rises with level of alcohol consumption.", "Bacteriophagaes MS2 and Q\u03b2 are members of the Leviviridae.", "VgrG (Tssl) protein punctures membranes by forming a spike at the tip of the tube apparatus.", "Post-transcriptional handling of mitochondrial transcripts occurs in mitochondrial RNA granules.", "TNFAIP3 is a glioblastoma tumor suppressor."], "hard_negatives": ["In rhesus macaques, daily subcutaneous injections of emtricitabine are ineffective at protecting against rectally transmitted simian-human immunodeficiency virus.", "In rhesus macaques, daily subcutaneous injections of tenofovir protects against rectally transmitted simian-human immunodeficiency virus.", "Eilat virus (EILV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in nonhuman primates.", "Nonhuman primates are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.", "Mice are incapable of producing neutralizing antibodies in reponse to the Chikungunya virus (CHIKV) produced in mosquitos.", "Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission.", "Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection decreases dissemination of Salmonella Typhimurium from the gut.", "Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection increases dissemination of Salmonella Typhimurium from the gut.", "A 100g dose of chloroquine chemoprophylactic regimen results in retinal toxicity after 1 year of weekly intake.", "Mice that lack Interferon-\u03b3 or its receptor are highly susceptible to experimental autoimmune myocarditis."], "hard_negative": "In rhesus macaques, daily subcutaneous injections of emtricitabine are ineffective at protecting against rectally transmitted simian-human immunodeficiency virus."}
{"query_id": "584", "query_text": "In rhesus macaques, daily subcutaneous injections of tenofovir protects against rectally transmitted simian-human immunodeficiency virus.", "negative": "Cancer-associated fibroblasts (CAFs) have no known interaction with cancer cells in the formation and activation of CAFs.", "negatives": ["Cancer-associated fibroblasts (CAFs) have no known interaction with cancer cells in the formation and activation of CAFs.", "The proliferative capacity of neural progenitors differs across species.", "Activator-inhibitor pairs are provided ventrally by Xrl-sizzled.", "The ability of activator E2Fs in preventing cell death is limited to terminally differentiated cells.", "70% of burn patients are admitted for hospitalization and further treatment after appearing at hospital emergency wards or outpatient clinics.", "Deltex interacts with eIF3. There is no known interaction between Deltex and elF3", "Primary cervical cytology screening with HPV detection has higher longitudinal sensitivity to detect severe cervical intraepithelial neoplasia than conventional cytology.", "Pediatric SCD patients with vaso-occlusive crisis show increased morphine use after breathing 80 ppm iNO for 4 hours.", "Over half of the gabonese children with Schimmelpenning-Feuerstein-Mims syndrome (SFM) had a plasma lactate of more than 5mmol/L.", "Microglia are an innate immune cell type of the peripheral nervous system."], "hard_negatives": ["In rhesus macaques, daily subcutaneous injections of tenofovir protects against rectally transmitted simian-human immunodeficiency virus.", "In rhesus macaques, daily subcutaneous injections of emtricitabine are ineffective at protecting against rectally transmitted simian-human immunodeficiency virus.", "Eilat virus (EILV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in nonhuman primates.", "Nonhuman primates are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.", "Mice are incapable of producing neutralizing antibodies in reponse to the Chikungunya virus (CHIKV) produced in mosquitos.", "Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission.", "Omnivores produce less trimethylamine N-oxide from dietary I-carnitine than vegans.", "Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection decreases dissemination of Salmonella Typhimurium from the gut.", "Omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegans.", "Sildenafil worsens erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants."], "hard_negative": "In rhesus macaques, daily subcutaneous injections of tenofovir protects against rectally transmitted simian-human immunodeficiency virus."}
{"query_id": "585", "query_text": "In the UK, drowning affects boys and girls equally.", "negative": "Enhanced early production of inflammatory chemokines damages viral control in the lung.", "negatives": ["Enhanced early production of inflammatory chemokines damages viral control in the lung.", "Including pharmacists in rounding teams does not alter the incidence of adverse drug events (ADEs).", "Upregulation of dynein in Drosophila neurons increases the number of microtubule plus-ends growing toward the cell body of each neuron.", "Bacteriophagaes MS2 and Q\u03b2 are members of the Leviviridae.", "The proportion of people with visual difficulty is two times higher in low-income countries than in high-income countries.", "Algerian physicians constitue the largest component of sub-Saharan Africa-trained physicians in the United States.", "Students who perform poorly in the early years of medical school are at increased risk for professional misconduct later in their careers.", "MafA ubiquitination increases the recruitment of coavtivator P/CAF by MafA.", "Adult tissue-resident macrophages stem from the embryonal yolk sac and fetal liver.", "At least 85% of patients exposed to radiation have activated markers of myofibroblasts."], "hard_negatives": ["In the UK, drowning affects boys and girls equally.", "Chlamydia trachomatis is most prevalent in the UK among sexually-experienced individuals aged 16 to 24.", "Tuberculosis incidence occurs at higher rates in more sparsely populated areas in the UK.", "There was an estimated 30 million cases of pneumonia in young children worldwide in 2010.", "The mean suicide rate in women is lower after miscarriage than live birth.", "The mean suicide rate in women is higher after miscarriage than live birth.", "10% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.", "90% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.", "The peak incidence of fractures occurs in toddlers.", "Chlamydia trachomatis is most prevalent in the UK among individuals in their 50s and 60s."], "hard_negative": "In the UK, drowning affects boys and girls equally."}
{"query_id": "588", "query_text": "In transgenic mice harboring green florescent protein under the control of the Sox2 promoter, more than 50 percent of the cells with green florescent colocalize with cell proliferation markers.", "negative": "There is a relation between Erythromycin use and hypertrophic pyloric stenosis.", "negatives": ["There is a relation between Erythromycin use and hypertrophic pyloric stenosis.", "H4 G94P proteins induce degradation of free histones via Rad53-dependent mechanisms.", "IL-10 production by monocytes inhibits CD4 + T cell response.", "The DESMOND program demonstrates no significant impact on lifestyles outcomes.", "Inhibiting focal adhesion formation enables cells to convert mechanical strain into eventual scarring.", "The innate immune response struggles to remove small numbers of parasites.", "Deltex interacts with eIF3. There is no known interaction between Deltex and elF3", "Human embryonic stem cells give rise to cell types from the outer embryonic germ layer, but not the other two layers.", "1 in 5 million in UK have abnormal PrP positivity.", "General exercise therapy is more effective than scapular stabilizer exercises in reducing pain and improving function of the shoulder."], "hard_negatives": ["In transgenic mice harboring green florescent protein under the control of the Sox2 promoter, more than 50 percent of the cells with green florescent colocalize with cell proliferation markers.", "Replacement of OCT4 and SOX2 genes with GATA3 has the ability to reprogram human cells.", "Replacement of OCT4 and SOX2 genes with GATA3 is not capable of reprogramming human cells.", "Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes fibrosis.", "The minor G allele of FOXO3 up-regulates IL-10.", "Cytosolic proteins bind to iron-responsive elements on mRNAs coding for TFRC1.", "TMEM27 is a marker for beta cells.", "Foxk2 regulates autophagy genes in muscle cells and fibroblast cells.", "The recruitment of Wdr5 to its target loci depends on Kat8.", "In S. cerevisiae, the absence of RNA surveillance pathways reduces sensitivity to high iron conditions."], "hard_negative": "In transgenic mice harboring green florescent protein under the control of the Sox2 promoter, more than 50 percent of the cells with green florescent colocalize with cell proliferation markers."}
{"query_id": "590", "query_text": "In young and middle-aged adults, current or remote uses of ADHD medications increase the risk of serious cardiovascular events.", "negative": "The DdrB protein from Deinococcus radiodurans functions as a pentamer.", "negatives": ["The DdrB protein from Deinococcus radiodurans functions as a pentamer.", "HIV trans-activator protein (TAT) effectively transports large and small molecules across cellular membranes into larger populations of neurons.", "Varying expression levels of EBI2 affect the positioning and migration of B cells.", "Upregulation of PD1 causes the upregulation of Satb1.", "Integrated care is successful at tackling multiple comorbidities.", "The tip of the inner tube of the toxic type VI secretion system (T6SS) antibacterial effector in Escherichia coli (E. coli) is decorated with VgrG and PAAR proteins.", "PrimPol degrades short DNA replication intermediates on the leading strand during DNA replication.", "The PRDM1 gene is a key determinant of primordial germ cells.", "Glycan adaptation involves insertion-deletion events.", "Cholesterol loading induces KLF4 expression in VSMCs, resulting in the expression of pro-inflammatory cytokines."], "hard_negatives": ["In young and middle-aged adults, current or remote uses of ADHD medications increase the risk of serious cardiovascular events.", "Side effects associated with antidepressants increases risk of stroke.", "Side effects associated with antidepressants do not represent a mortality risk to postmenopausal women.", "Side effects associated with antidepressants lower risk of myocardial infarction.", "Antidepressants increase the severity of migraines.", "Antidepressants reduce the severity of migraines.", "In patients with congenital heart defects, \u03b2-blockers significantly improve clinical heart failure outcomes.", "The most prevalent adverse events to Semaglutide are cardiovascular.", "Risk of cardiovascular events can be cut by a third by using antihypertensive drug therapy among hemodialysis patients.", "Medications to treat obesity have unwanted side effects."], "hard_negative": "In young and middle-aged adults, current or remote uses of ADHD medications increase the risk of serious cardiovascular events."}
{"query_id": "591", "query_text": "Incidence of 10/66 dementia is higher than the incidence of DSM-IV dementia.", "negative": "Concentrations of SNV and CNV in stem-cell regulatory elements and binding sites of transcription factors in iPSC-lines are distinct from their founding cells.", "negatives": ["Concentrations of SNV and CNV in stem-cell regulatory elements and binding sites of transcription factors in iPSC-lines are distinct from their founding cells.", "Urbanization is an important risk factor related to the transmission of dengue fever.", "Rising temperatures caused by global warming increases risk of dengue fever transmission.", "Mutant mice lacking SVCT2 have severely reduced ascorbic acid levels in both brain and adrenals.", "Exercise increases cancer mortality rates among Chinese citizens.", "Inside the body, falciparum parasites reproduce asexually.", "It is not proven that moderate consumption of candy and chocolate reduces the risk of cardiovascular disease (CVD) specifically.", "Systemic immunosuppressive (IS) therapy increases the chance of cancer mortality in patients with inflammatory eye disease (IED)", "aPKCz causes tumour suppression by affecting glutamine metabolism.", "The G34R/V mutation does not create a hypomethylated phenotype at the H3K36 histone."], "hard_negatives": ["Incidence of 10/66 dementia is higher than the incidence of DSM-IV dementia.", "Incidence of 10/66 dementia is lower than the incidence of DSM-IV dementia.", "Asymptomatic visual impairment screening in elderly populations leads to improved vision.", "Individuals with Alzheimers who participate in six months of physical activity improve cognitive function for up to 18 months.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have decreased risk for dementia.", "Headaches are correlated with cognitive impairment.", "90% of patients with melanoma and an objective response to PD-1 blockade will experience a progression in their melanoma.", "Physical activity does not improve cognitive function in individuals with Alzheimers.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have increased risk for Alzheimer's disease.", "Chlamydia trachomatis is most prevalent in the UK among individuals in their 50s and 60s."], "hard_negative": "Incidence of 10/66 dementia is higher than the incidence of DSM-IV dementia."}
{"query_id": "592", "query_text": "Incidence of 10/66 dementia is lower than the incidence of DSM-IV dementia.", "negative": "p16INK4A degradation is encoded by CDKN2A.", "negatives": ["p16INK4A degradation is encoded by CDKN2A.", "Normal granulomas form in the absence of TNF in Zebrafish.", "Emodin forms hydrogen bonds with residues involved in PGAM1 substrate binding.", "Tirasemtiv targets fast-twitch muscle.", "Sympathetic nerve activity is reduced throughout normal pregnancy.", "RANK-RANKL pathway signalling has no known association with development of Aire-expressing medullary thymic epithelial cells.", "Patients with microcytosis and higher erythrocyte count are more vulnerable to severe malarial anaemia when infected with Plasmodium falciparum.", "Bariatric surgery reduces colorectal cancer.", "Tonic signaling from the scFv prevents constitutive stimulation.", "Hypocretin neurones suppress panicprone state in rats."], "hard_negatives": ["Incidence of 10/66 dementia is lower than the incidence of DSM-IV dementia.", "Incidence of 10/66 dementia is higher than the incidence of DSM-IV dementia.", "Asymptomatic visual impairment screening in elderly populations leads to improved vision.", "Individuals with Alzheimers who participate in six months of physical activity improve cognitive function for up to 18 months.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have decreased risk for dementia.", "90% of patients with melanoma and an objective response to PD-1 blockade will experience a progression in their melanoma.", "Headaches are correlated with cognitive impairment.", "Physical activity does not improve cognitive function in individuals with Alzheimers.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have increased risk for Alzheimer's disease.", "Chlamydia trachomatis is most prevalent in the UK among individuals in their 50s and 60s."], "hard_negative": "Incidence of 10/66 dementia is lower than the incidence of DSM-IV dementia."}
{"query_id": "594", "query_text": "Incidence of heart failure increased by 10% in women since 1979.", "negative": "Rapamycin increases the concentration of triacylglycerols in fruit flies.", "negatives": ["Rapamycin increases the concentration of triacylglycerols in fruit flies.", "IgA plasma cells that are specific for transglutaminase 2 are scarce in the duodenal mucosa of celiac disease patients when the disease is active.", "Adult tissue-resident macrophages are seeded before birth.", "Human embryonic stem cells give rise to cell types from the outer embryonic germ layer, but not the other two layers.", "Active caspase-11 participate in regulating phagosome-lysosome fusion.", "Differentiation of progenitor cells to myeloid cells is skewed upon activation of insulin signaling.", "Guanine nucleotide dissociation inhibitor (Rho-GDI) interacts with the p75 NTR death domain", "N348I mutations reduce resistance to nevirapine.", "Adult tissue-resident macrophages possess a self-renewing capacity.", "Ultrasound guidance significantly reduces the number of traumatic procedures when attempting needle insertion."], "hard_negatives": ["Incidence of heart failure increased by 10% in women since 1979.", "The mean suicide rate in women is higher after miscarriage than live birth.", "The mean suicide rate in women is lower after miscarriage than live birth.", "90% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.", "10% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.", "The risk of breast cancer among parous women decreases with placental weight of pregnancies.", "Sepsis related mortality has risen from 2009 to 2014.", "Incidence of sepsis has fallen substantially from 2009 to 2014.", "Women with a lower birth weight are more likely to develop breast cancer later in life.", "53% of perinatal mortality is due to low birth weight."], "hard_negative": "Incidence of heart failure increased by 10% in women since 1979."}
{"query_id": "595", "query_text": "Incidence of sepsis has fallen substantially from 2009 to 2014.", "negative": "ITAM phosphorylation allows for the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).", "negatives": ["ITAM phosphorylation allows for the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).", "Origin gross domestic product(GDP) is negatively related to dengue virus (DENV-1) diffusion in air traffic shipments.", "The most prevalent adverse events to Semaglutide are gastrointestinal.", "taa1 tar1 tar2 triple mutants in Arabidopsis do not make root meristem during embryogenesis.", "Physical activity does not improve cognitive function in individuals with Alzheimers.", "Taxation of sugar-sweetened beverages reduced the incidence rate of type II diabetes in India.", "Foxp3 enables the expression of transcriptional regulators implicated in memory T cell development.", "Cardiac tissue-resident macrophages directly contribute to electrical activity.", "Toll-like receptor (TLR) signaling is involved in the pathogenesis of human MDS.", "The minor G allele of FOXO3 is related to less severe symptoms of Crohn's Disease."], "hard_negatives": ["Incidence of sepsis has fallen substantially from 2009 to 2014.", "Sepsis related mortality has risen from 2009 to 2014.", "Sepsis related mortality has remained stable between 2009-2014.", "The mean suicide rate in women is higher after miscarriage than live birth.", "The mean suicide rate in women is lower after miscarriage than live birth.", "90% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.", "10% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.", "There was an estimated 30 million cases of pneumonia in young children worldwide in 2010.", "Tuberculosis incidence occurs at higher rates in more sparsely populated areas in the UK.", "Incidence of heart failure increased by 10% in women since 1979."], "hard_negative": "Incidence of sepsis has fallen substantially from 2009 to 2014."}
{"query_id": "600", "query_text": "Including pharmacists in rounding teams does not alter the incidence of adverse drug events (ADEs).", "negative": "ITAM phosphorylation allows for the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).", "negatives": ["ITAM phosphorylation allows for the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).", "Monoclonal antibody targeting of N-cadherin encourages metastasis.", "7-day-old adult Caenorhabditis elegans exhibit approximately 5% of the learning capacity seen in 1-day old adults.", "Neutrophil extracellular trap (NET) antigens may contain the targeted autoantigens PR3 and MPO.", "Oxidative DNA damage inhibits STING signalling.", "Citrullinated proteins externalized in neutrophil extracellular traps act indirectly to perpetuate the inflammatory cycle via induction of autoantibodies.", "Genes involved in pre-mRNA splicing have a significant impact on genome stability.", "Antimicrobial agents are less effective due to the pressure of antimicrobial usage.", "Pyridostatin decreases telomere fragility in BRCA2-deficient cells.", "Ethanol stress increases the expression of PSP in bacteria."], "hard_negatives": ["Including pharmacists in rounding teams does not alter the incidence of adverse drug events (ADEs).", "Including pharmacists in rounding teams reduces the incidence of adverse drug events (ADEs).", "Pharmacist attendance at ward rounds increases adverse events in wards.", "Pharmacist attendance at ward rounds reduces adverse events in wards.", "Assessing treatment adherence is more beneficial to clinical practice than measuring routine outcomes.", "Measuring routine outcomes is more beneficial to clinical practice than assessing treatment adherence.", "Risk of cardiovascular events can be cut by a third by using antihypertensive drug therapy among hemodialysis patients.", "In young and middle-aged adults, current or remote uses of ADHD medications increase the risk of serious cardiovascular events.", "The most prevalent adverse events to Semaglutide are cardiovascular.", "Cost effectiveness evaluations based on cRCT data accurately reflect prices for patients in actual clinical practice."], "hard_negative": "Including pharmacists in rounding teams does not alter the incidence of adverse drug events (ADEs)."}
{"query_id": "601", "query_text": "Including pharmacists in rounding teams reduces the incidence of adverse drug events (ADEs).", "negative": "Ribosomal protein (RP) expression is controlled in part by stress-activated regulators.", "negatives": ["Ribosomal protein (RP) expression is controlled in part by stress-activated regulators.", "Human embryonic stem cells have the capacity to give rise to differentiated progeny representative of all three embryonic germ layers.", "ScPif1p has higher binding ability to G-rich ssDNA than to non-G-rich ssDNA.", "The PRDM1 gene is a key determinant of primordial germ cells.", "Mutations in RIM1 raise levels of IME1 RNA.", "Excess gestational weight gain is associated with obesity-related pregnancy outcomes.", "The composition of myosin-II isoform switches from the A isoform to the B isoform during hematopoietic differentiation.", "Adult tissue-resident macrophages stem from the embryonal yolk sac and fetal liver.", "Cytochrome c is transferred from cytosol to the mitochondrial intermembrane space during apoptosis.", "De novo assembly of sequence data has shorter contigs than unassembled sequence data."], "hard_negatives": ["Including pharmacists in rounding teams reduces the incidence of adverse drug events (ADEs).", "Including pharmacists in rounding teams does not alter the incidence of adverse drug events (ADEs).", "Pharmacist attendance at ward rounds reduces adverse events in wards.", "Pharmacist attendance at ward rounds increases adverse events in wards.", "Assessing treatment adherence is more beneficial to clinical practice than measuring routine outcomes.", "Measuring routine outcomes is more beneficial to clinical practice than assessing treatment adherence.", "Cost effectiveness evaluations based on cRCT data accurately reflect prices for patients in actual clinical practice.", "In young and middle-aged adults, current or remote uses of ADHD medications increase the risk of serious cardiovascular events.", "Risk of cardiovascular events can be cut by a third by using antihypertensive drug therapy among hemodialysis patients.", "Diabetic patients with acute coronary syndrome experience decreased short-term and long-term risk for bleeding events."], "hard_negative": "Including pharmacists in rounding teams reduces the incidence of adverse drug events (ADEs)."}
{"query_id": "602", "query_text": "Increase of p62 in prostate tumor stroma results in defective autophagy.", "negative": "The PRDM1 gene is a key determinant of primordial germ cells.", "negatives": ["The PRDM1 gene is a key determinant of primordial germ cells.", "Over half of the gabonese children with Schimmelpenning-Feuerstein-Mims syndrome (SFM) had a plasma lactate of more than 5mmol/L.", "The PRDM1 gene is a key determinant of primordial germ cells.", "Intake of folic acid (FA) and vitamin B6 (VB6) reduces levels of homocysteine.", "Splenomegaly is observed in knockin mouse lacking the SHP-2 MAPK pathway.", "Genomic aberrations of metastases provide information for targeted therapy.", "Flexible molecules experience less steric hindrance in the tumor microenviroment than rigid molecules.", "In the UK, drowning affects boys and girls equally.", "A diminished ovarian reserve does not solely indicate infertility in an a priori non-infertile population.", "The US health care system can save up to $5 billion if 7% of patients waiting for kidney transplants participate in the optimized national kidney paired donation program."], "hard_negatives": ["Decrease of p62 in prostate tumor stroma results in defective autophagy.", "Increase of p62 in prostate tumor stroma results in defective autophagy.", "Taking 400mg of \u03b1-tocopheryl acetate does not prevent prostate cancer.", "Pioglitazone use is not associated with an increased risk of prostate cancer.", "Pioglitazone use is significantly associated with an increased risk of prostate cancer.", "Taking 400mg of \u03b1-tocopheryl acetate in combination with vitamin C reduces the risk of prostate cancer.", "Activation of PPM1D enhances p53 function.", "Upregulation of PD1 causes the upregulation of Satb1.", "Reduced levels of lipolysis leads to higher P38 phosphorylation in adipose tissue.", "Upregulation of PD1 causes the downmodulation of Satb1."], "hard_negative": "Decrease of p62 in prostate tumor stroma results in defective autophagy."}
{"query_id": "603", "query_text": "Increased LDL receptors plays a role in the reduction of plasma Lp(a).", "negative": "Lack of FGF21 in mice increases life expectancy.", "negatives": ["Lack of FGF21 in mice increases life expectancy.", "Antimicrobial agents are less effective due to the pressure of antimicrobial usage.", "Systemic lupus erythematosus is a risk factor for cardiovascular disease.", "Moderate consumption of candy and chocolate reduces the risk of cardiovascular disease (CVD).", "Type 1 Diabetes is associated with subtle perturbations in T reg development.", "Microcin J25 inhibits nucleoside triphosphate (NTP) binding.", "Vaccinating the gastrointestinal tract induces protection of rectal and vaginal mucosa.", "Asymptomatic visual impairment screening in elderly populations leads to improved vision.", "LRBA promotes CTLA - 4 recycling.", "C2 works synergistically with A-769662 to activate dephosphorylated AMPK."], "hard_negatives": ["Increased LDL receptors plays a role in the reduction of plasma Lp(a).", "PCSK9 inhibitors decrease plasma Lp(a) levels.", "LDL cholesterol has a causal role in the development of cardiovascular disease.", "Increased conversion of PGE 2 to PPARy ligand 15-ket-PGE 2 causes accumulation of PGE.", "Decreased conversion of PGE 2 to PPARy ligand 15-ket-PGE 2 causes accumulation of PGE.", "AMP-activated protein kinase (AMPK) activation reduces inflammation-related fibrosis in the lungs.", "Inhibiting glucose-6-phospate dehydrogenase improves lipogenesis by deactivating LKB1-AMPK signaling.", "The density of cytokine receptor bearing cells has no effect on the distance over which cytokines act.", "Depletion of nitric oxide is responsible for vasospasm.", "High levels of CRP lead to a higher risk of exacerbations in chronic obstructive pulmonary disease (COPD)."], "hard_negative": "Increased LDL receptors plays a role in the reduction of plasma Lp(a)."}
{"query_id": "606", "query_text": "Increased conversion of PGE 2 to PPARy ligand 15-ket-PGE 2 causes accumulation of PGE.", "negative": "B3-Galectin increases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR.", "negatives": ["B3-Galectin increases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR.", "Taking 400mg of \u03b1-tocopheryl acetate in combination with vitamin C reduces the risk of prostate cancer.", "Mouse models can be generated using \"artificial spermatids.\"", "Increased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm.", "ART has no effect on the infectiveness of HIV-positive people.", "Bariatric surgery leads to negative outcomes in mental health.", "Active caspase-11 participate in regulating phagosome-lysosome fusion.", "Deleting Raptor increases G-CSF levels.", "Pediatric SCD patients with vaso-occlusive crisis show increased morphine use after breathing 80 ppm iNO for 4 hours.", "British female students are bullied more than British male students."], "hard_negatives": ["Increased conversion of PGE 2 to PPARy ligand 15-ket-PGE 2 causes accumulation of PGE.", "Decreased conversion of PGE 2 to PPARy ligand 15-ket-PGE 2 causes accumulation of PGE.", "High levels of CRP lead to a higher risk of exacerbations in chronic obstructive pulmonary disease (COPD).", "PKG-la does not have a large impact on expression of pain hypersensitivity in PGK-la knockout mice.", "PGE 2 suppresss intestinal tumor growth by altering the expression of tumor suppressing and DNA repair genes.", "Reduced phosphorylation of PP2A increases HDAC4 dephosphorylation by enhancing PP2A-HDAC4 interaction.", "Increased LDL receptors plays a role in the reduction of plasma Lp(a).", "Reduced phosphorylation of PP2A suppresses HDAC4 dephosphorylation.", "PCSK9 inhibitors decrease plasma Lp(a) levels.", "There is no increased risk of hypospadias with clomiphene."], "hard_negative": "Increased conversion of PGE 2 to PPARy ligand 15-ket-PGE 2 causes accumulation of PGE."}
{"query_id": "607", "query_text": "Increased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm.", "negative": "Prescribed exercise training improves quality of life.", "negatives": ["Prescribed exercise training improves quality of life.", "Pyridostatin decreases telomere fragility in BRCA2-deficient cells.", "The tissue surrounding the granuloma in an immune cell induces an anti-inflammatory immune response.", "The appearance of brown-like or beige cells primarily occurs in visceral fat, not subcutaneous fat.", "Interleukin-18 plays an important role in the pathogenesis of atherosclerosis.", "Walking in traffic areas in London improves lung function in elderly adults.", "Increase of p62 in prostate tumor stroma results in defective autophagy.", "Persistor cells are one reason for incomplete responses to Tyrosine kinase inhibitor (TKI) therapy in cancer patients.", "Birth-weight is negatively associated with breast cancer.", "CD44v6 is not associated with constitutive and reprogrammed cancer stem cells driving cancer metastasis."], "hard_negatives": ["Increased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm.", "Decreased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm.", "Ambulatory blood pressure monitoring is inaccurate at diagnosing hypertension.", "Sudden death can occur in patients with orthostatic hypertension without cardiac conduction abnormalities.", "CRP is positively correlated with postoperative mortality following Coronary Artery Bypass Graft (CABG) surgery.", "High levels of CRP lead to a higher risk of exacerbations in chronic obstructive pulmonary disease (COPD).", "Sudden death can occur in patients with complex ventricular arrhythmias.", "AMP-activated protein kinase (AMPK) activation reduces inflammation-related fibrosis in the lungs.", "Diabetic patients with acute coronary syndrome experience decreased short-term and long-term risk for bleeding events.", "Noninvasive positive pressure ventilation is not predictive of acute respiratory failure after solid organ transplantation."], "hard_negative": "Increased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm."}
{"query_id": "609", "query_text": "Increased flux of microbial products provokes immune responses.", "negative": "Toll-like receptor (TLR) signaling is involved in the pathogenesis of human MDS.", "negatives": ["Toll-like receptor (TLR) signaling is involved in the pathogenesis of human MDS.", "Intake of folic acid (FA) and vitamin B6 (VB6) increases levels of homocysteine.", "Increased microtubule acetylation worsens interference of axonal transport caused by LRRK2 Roc-COR domain mutations.", "Patients with panic anxiety show decreased CSF levels of hypocretin.", "The proliferative capacity of neural progenitors differs across species.", "Pseudoknots are not evolutionarily conserved in most eukaryotes.", "The risk of cancer rises with level of alcohol consumption.", "APOE4 expression in iPSC-derived neurons results in decreased tau phosphorylation.", "Oxidative DNA damage activates STING signalling.", "Men are more susceptible to death due to pneumonia when compared to women."], "hard_negatives": ["Increased flux of microbial products provokes immune responses.", "Increased flux of microbial products suppresses immune responses.", "Antimicrobial agents are more effective due to the pressure of antimicrobial usage.", "Antimicrobial agents are less effective due to the pressure of antimicrobial usage.", "The innate immune response struggles to remove small numbers of parasites.", "The tissue surrounding the granuloma in an immune cell induces an anti-inflammatory immune response.", "Chronic HIV stimulation of B cells leads to the premature exhaustion of B cells.", "Tuberculosis-induced granulomas express different immune system protein signatures than the surrounding tissue.", "Immune responses in immune cells are geographically segregated.", "Enhanced early production of inflammatory chemokines damages viral control in the lung."], "hard_negative": "Increased flux of microbial products provokes immune responses."}
{"query_id": "610", "query_text": "Increased flux of microbial products suppresses immune responses.", "negative": "Albendazole is used to treat soil-transmitted helminths.", "negatives": ["Albendazole is used to treat soil-transmitted helminths.", "Inhibiting focal adhesion formation enables cells to convert mechanical strain into eventual scarring.", "A mutation in HNF4A leads to an increased risk of diabetes by the age of 14 years.", "Addition of BMP4, activin A, CHIR99021, and SU504 to reprogramming fibroblasts generates, expands and maintains cardiovascular progenitor cells (CPCs)", "Sympathetic nerve activity is reduced throughout normal pregnancy.", "Chronic HIV stimulation of B cells leads to the premature exhaustion of B cells.", "Aggravated inflammation is dependent on NLRP3 inflammasome activation.", "Women with a lower birth weight are more likely to develop breast cancer later in life.", "Pyridostatin reduces proliferation of homologous recombination - defective cells.", "Nonhuman primates are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos."], "hard_negatives": ["Increased flux of microbial products provokes immune responses.", "Increased flux of microbial products suppresses immune responses.", "Antimicrobial agents are less effective due to the pressure of antimicrobial usage.", "Antimicrobial agents are more effective due to the pressure of antimicrobial usage.", "The innate immune response struggles to remove small numbers of parasites.", "Enhanced early production of inflammatory chemokines damages viral control in the lung.", "Immune responses in immune cells are geographically segregated.", "The tissue surrounding the granuloma in an immune cell induces an anti-inflammatory immune response.", "Chronic HIV stimulation of B cells leads to the premature exhaustion of B cells.", "Tuberculosis-induced granulomas express different immune system protein signatures than the surrounding tissue."], "hard_negative": "Increased flux of microbial products provokes immune responses."}
{"query_id": "611", "query_text": "Increased lipolysis leads to higher P38 phosphorylation in adipose tissue.", "negative": "The minor G allele of FOXO3 is related to less severe symptoms of Crohn's Disease.", "negatives": ["The minor G allele of FOXO3 is related to less severe symptoms of Crohn's Disease.", "Integrated care is successful at tackling multiple comorbidities.", "Toll-like receptor (TLR) signaling is involved in the pathogenesis of human MDS.", "H4 G94P proteins inhibit chromatin assembly, which decreases free histones.", "A diminished ovarian reserve does not solely indicate infertility in an a priori non-infertile population.", "Bone Marrow (BM) transplantation is used to treat acute myeloid leukemia (AML)", "The ability of activator E2Fs in preventing cell death is limited to terminally differentiated cells.", "Bariatric surgery reduces colorectal cancer.", "CDK6 shows improved binding to loss-of-function variants of p18 INK4C.", "KLF4 is necessary for VSMCs to gain genetic characteristics of other cell types within atherosclerotic lesions."], "hard_negatives": ["Increased lipolysis leads to higher P38 phosphorylation in adipose tissue.", "Reduced levels of lipolysis leads to higher P38 phosphorylation in adipose tissue.", "Inhibiting glucose-6-phospate dehydrogenase improves lipogenesis by deactivating LKB1-AMPK signaling.", "AMP-activated protein kinase (AMPK) activation reduces inflammation-related fibrosis in the lungs.", "Chenodeoxycholic acid treatment increases brown adipose tissue activity.", "The M2-phenotype in brown adipose tissue macrophages increases brown adipose tissue thermogenic activity.", "The morphology change from large white adipocytes to small brown adipocytes is a sign of increased energy expenditure potential in white adipose tissue.", "The morphology change from large white adipocytes to small brown adipocytes is a sign of decreased energy expenditure potential in white adipose tissue.", "Chenodeoxycholic acid treatment decreases brown adipose tissue activity.", "APOE4 expression in iPSC-derived neurons results in decreased tau phosphorylation."], "hard_negative": "Increased lipolysis leads to higher P38 phosphorylation in adipose tissue."}
{"query_id": "612", "query_text": "Increased microtubule acetylation exacerbates LRRK2 Roc-COR domain mutation induced locomotor deficits.", "negative": "Inhibiting glucose-6-phospate dehydrogenase improves lipogenesis by deactivating LKB1-AMPK signaling.", "negatives": ["Inhibiting glucose-6-phospate dehydrogenase improves lipogenesis by deactivating LKB1-AMPK signaling.", "Mice lacking Sirt1 in Sf1-expressing neurons are immune to diet-induced obesity and insulin resistance.", "The one-child policy has created a hospitable environment for female infants.", "Incidence of sepsis has fallen substantially from 2009 to 2014.", "Measuring routine outcomes is more beneficial to clinical practice than assessing treatment adherence.", "Excess gestational weight gain is associated with obesity-related pregnancy outcomes.", "Notch signaling occurs between tumor cells and stromal cells.", "Increased microtubule acetylation worsens interference of axonal transport caused by LRRK2 Roc-COR domain mutations.", "Pharmacist attendance at ward rounds increases adverse events in wards.", "Nonhuman primates are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos."], "hard_negatives": ["Increased microtubule acetylation exacerbates LRRK2 Roc-COR domain mutation induced locomotor deficits.", "Increased microtubule acetylation worsens interference of axonal transport caused by LRRK2 Roc-COR domain mutations.", "Increased microtubule acetylation repairs interference of axonal transport caused by LRRK2 Roc-COR domain mutations.", "Gpr124 suppresses BBB breakdown in mouse models of ischemic stroke.", "Activated Cdk5 phosphorylates the ATM protein in response to DNA damage.", "ATM and Rad3 related protein have no role in sensing DNA damage.", "Deletion of ATM and Rad3 related protein leads to acute tissue loss.", "Gpr124 increases BBB breakdown in mouse models of ischemic stroke.", "ATM and Rad3 related protein are critical for sensing DNA damage.", "CD28 initiates tonic signaling in conventional T cells, which causes an exhaustion phenotype and limited efficiency."], "hard_negative": "Increased microtubule acetylation exacerbates LRRK2 Roc-COR domain mutation induced locomotor deficits."}
{"query_id": "614", "query_text": "Increased microtubule acetylation repairs interference of axonal transport caused by LRRK2 Roc-COR domain mutations.", "negative": "Female carriers of the Apolipoprotein E4 (APOE4) allele have decreased risk for dementia.", "negatives": ["Female carriers of the Apolipoprotein E4 (APOE4) allele have decreased risk for dementia.", "Replacement of OCT4 and SOX2 genes with GATA3 has the ability to reprogram human cells.", "RUNX1 is downregulated or mutated in TLX1 T-ALL.", "M. stadtmanae induces ASC speck formation in BlaER1 monocytes.", "90% of patients with melanoma and an objective response to PD-1 blockade will experience a progression in their melanoma.", "MafA ubiquitination decreases the recruitment of coavtivator P/CAF by MafA.", "Active caspase-11 participate in regulating phagosome-lysosome fusion.", "Major vault protein regulates sorting of tumor suppressive miR-193a into EVs.", "PrimPol generates short DNA replication intermediates on the leading strand during DNA replication.", "L3MBTL2 binds to H2AK119Ub marked chromatin to form a PRC1 complex."], "hard_negatives": ["Increased microtubule acetylation repairs interference of axonal transport caused by LRRK2 Roc-COR domain mutations.", "Increased microtubule acetylation worsens interference of axonal transport caused by LRRK2 Roc-COR domain mutations.", "Increased microtubule acetylation exacerbates LRRK2 Roc-COR domain mutation induced locomotor deficits.", "L3MBTL2 binds to H2AK119Ub marked chromatin to form a PRC1 complex.", "ATM and Rad3 related protein have no role in sensing DNA damage.", "Activated Cdk5 phosphorylates the ATM protein in response to DNA damage.", "ATM and Rad3 related protein are critical for sensing DNA damage.", "Deletion of ATM and Rad3 related protein leads to acute tissue loss.", "ITAM phosphorylation allows for the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).", "B3-Galectin decreases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR."], "hard_negative": "Increased microtubule acetylation repairs interference of axonal transport caused by LRRK2 Roc-COR domain mutations."}
{"query_id": "615", "query_text": "Increased microtubule acetylation worsens interference of axonal transport caused by LRRK2 Roc-COR domain mutations.", "negative": "The morphology change from large white adipocytes to small brown adipocytes is a sign of decreased energy expenditure potential in white adipose tissue.", "negatives": ["The morphology change from large white adipocytes to small brown adipocytes is a sign of decreased energy expenditure potential in white adipose tissue.", "The origin of the CRF01_1b2k protein occurred between 1923 and 1956.", "siRNA knockdown of A20 slows tumor progression in an in vivo murine xenograft model.", "Bariatric surgery leads to positive outcomes in mental health.", "Albendazole is used to treat soil-transmitted helminths.", "Folate and vitamin B12 levels influence the association between homocysteine and preeclampsia.", "Genetic deficiency of mast cells leads to decreased weight gain in a mouse model of diet-induced obesity.", "M. stadtmanae induces ASC speck formation in BlaER1 monocytes.", "In transgenic mice harboring green florescent protein under the control of the Sox2 promoter, more than 50 percent of the cells with green florescent colocalize with cell proliferation markers.", "Transplanted human glial progenitor cells can mature in their host animal."], "hard_negatives": ["Increased microtubule acetylation worsens interference of axonal transport caused by LRRK2 Roc-COR domain mutations.", "Increased microtubule acetylation repairs interference of axonal transport caused by LRRK2 Roc-COR domain mutations.", "Increased microtubule acetylation exacerbates LRRK2 Roc-COR domain mutation induced locomotor deficits.", "L3MBTL2 binds to H2AK119Ub marked chromatin to form a PRC1 complex.", "Deletion of ATM and Rad3 related protein leads to acute tissue loss.", "Activated Cdk5 phosphorylates the ATM protein in response to DNA damage.", "ATM and Rad3 related protein have no role in sensing DNA damage.", "CD28 signals regulate trafficking of murine auto-reactive T cells into target tissues.", "ITAM phosphorylation allows for the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).", "Gpr124 suppresses BBB breakdown in mouse models of ischemic stroke."], "hard_negative": "Increased microtubule acetylation worsens interference of axonal transport caused by LRRK2 Roc-COR domain mutations."}
{"query_id": "616", "query_text": "Increased mobility of retrotransposons does not lead to mutation and higher tumorigenesis rates.", "negative": "The PRDM1 gene is a key determinant of primordial germ cells.", "negatives": ["The PRDM1 gene is a key determinant of primordial germ cells.", "Ambulatory blood pressure monitoring is inaccurate at diagnosing hypertension.", "Physical activity level is associated with the difference in maximal oxygen consumption between black and white youth.", "Women with a lower birth weight are more likely to develop breast cancer later in life.", "Bariatric surgery reduces colorectal cancer.", "Having a main partner improves HIV outcomes.", "Patients in stable partnerships progress from HIV to death at the same rate as patients not in partnerships.", "N348I mutations cause resistance to nevirapine.", "Upregulation of dynein in Drosophila neurons increases the number of microtubule plus-ends growing toward the cell body of each neuron.", "Neutrophils produce IL-1\u03b2 in response to large particles."], "hard_negatives": ["Increased mobility of retrotransposons does not lead to mutation and higher tumorigenesis rates.", "Increased mobility of retrotransposons is assosciated with mutation and higher tumorigenesis rates.", "Up-regulation of the p53 pathway and related molecular events speeds cancer progression.", "Genes involved in pre-mRNA splicing have a significant impact on genome stability.", "siRNA knockdown of A20 accelerates tumor progression in an in vivo murine xenograft model.", "siRNA knockdown of A20 slows tumor progression in an in vivo murine xenograft model.", "Carriers of HNF4A mutations are at reduced risk for diabetes.", "The generation of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells.", "Understanding epigenetic regulation of replication is essential for the reational design of episomally replicating vectors.", "The removal of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells."], "hard_negative": "Increased mobility of retrotransposons does not lead to mutation and higher tumorigenesis rates."}
{"query_id": "617", "query_text": "Increased mobility of retrotransposons is assosciated with mutation and higher tumorigenesis rates.", "negative": "A diminished ovarian reserve is a very strong indicator of infertility, even in an a priori non-infertile population.", "negatives": ["A diminished ovarian reserve is a very strong indicator of infertility, even in an a priori non-infertile population.", "B3-Galectin decreases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR.", "Obesity raises life quality.", "Forkhead 0 (fox0) transcription factors are involved in cellular differentiation.", "Dexamethasone increases risk of postoperative bleeding.", "Cardiac tissue-resident macrophages directly contribute to electrical activity.", "Healthy volunteers exhibit rapid and transient increase of cellular ATP after being bolus-injected with fructose.", "Ethanol stress increases the expression of IBP in bacteria.", "The origin of the CRF01_1b2k protein occurred between 1923 and 1956.", "A mutation in HNF4A leads to an increased risk of developing diabetes by the age of 14 years."], "hard_negatives": ["Increased mobility of retrotransposons is assosciated with mutation and higher tumorigenesis rates.", "Increased mobility of retrotransposons does not lead to mutation and higher tumorigenesis rates.", "Up-regulation of the p53 pathway and related molecular events speeds cancer progression.", "Genes involved in pre-mRNA splicing have a significant impact on genome stability.", "siRNA knockdown of A20 accelerates tumor progression in an in vivo murine xenograft model.", "siRNA knockdown of A20 slows tumor progression in an in vivo murine xenograft model.", "Carriers of HNF4A mutations are at reduced risk for diabetes.", "The generation of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells.", "Homozygous deletion of murine Sbds gene from osterix-expressing mesenchymal stem and progenitor cells (MPCs) induces oxidative stress.", "The removal of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells."], "hard_negative": "Increased mobility of retrotransposons is assosciated with mutation and higher tumorigenesis rates."}
{"query_id": "618", "query_text": "Increased purity of cytoplasmic membranes isolated from overexpressors is indicated by stronger spots for OmpF in 2D BN-PAGE gels.", "negative": "Egr3 regulates the homeostasis of B and T cells.", "negatives": ["Egr3 regulates the homeostasis of B and T cells.", "BRCA 1 mutation carriers' risk of breast and ovarian cancer depends on where the mutation is located.", "Fibroblast Growth Factor is a ligand which signals through receptor tyrosine kinases.", "Intake of folic acid (FA) and vitamin B6 (VB6) increases levels of homocysteine.", "Rising temperatures caused by global warming increases risk of dengue fever transmission.", "Nigerian physicians constitue the largest component of sub-Saharan Africa-trained physicians in the United States.", "Mice defective for deoxyribonucleic acid (DNA) polymerase m (polm) fail to reveal increased sensitivity to ionizing radiation (IR).", "Sildenafil worsens erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.", "Angiotensin converting enzyme inhibitors are associated with decreased risk for functional renal insufficiency.", "The deamination of cytidine to uridine on the minus strand of viral DNA can inactivate the viral genome by inducing G-to-A mutations."], "hard_negatives": ["Increased purity of cytoplasmic membranes isolated from overexpressors is indicated by stronger spots for OmpF in 2D BN-PAGE gels.", "Reduction of purity of cytoplasmic membranes isolated from overexpressors is indicated by stronger spots for OmpF in 2D BN-PAGE gels.", "Reduction of purity of cytoplasmic membranes isolated from overexpressors is indicated by stronger spots for OmpA in 2D BN-PAGE gels.", "Intramembrane cleavage by signal peptide peptidase aids in the degradation of proteins with a complex membrane orientation.", "Lamins have no effect on nuclear membrane structure maintenance.", "The microtubule-dependent delivery and secretion of matrix metalloproteases (MMPs) is partially responsible for the disassembly of adhesion sites.", "Broadly HIV-1 Neutralizing Antibodies (bnAb) 10EB have no affinity for phospholipids.", "Many transmembrane receptors transmit signals by long-range conformational changes in the association of alpha-helices across the plasma membrane.", "\u03b21/Ketel is able to bind microtubules.", "PRC1-bound plasmids sediment at a slower rate in unbound plasmids than in sucrose gradients."], "hard_negative": "Increased purity of cytoplasmic membranes isolated from overexpressors is indicated by stronger spots for OmpF in 2D BN-PAGE gels."}
{"query_id": "620", "query_text": "Increased vessel density along with a reduction in fibrosis improves the efficacy of chemotherapy treatments.", "negative": "There is no known interaction between Pioneer factor OCT3/4 and major chromatin remodeling factors.", "negatives": ["There is no known interaction between Pioneer factor OCT3/4 and major chromatin remodeling factors.", "During the primary early antibody response activated B cells migrate toward the inner-and outer follicular areas where oxysterol accumulation is generated by stromal cells.", "Primary cervical cytology screening with HPV detection has higher longitudinal sensitivity to detect severe cervical intraepithelial neoplasia than conventional cytology.", "Risedronate increases risk of vertebral and non-vertebral fractures.", "The predominant localization of Linc00173 is in mononuclear macrophage nuclei.", "IL-10 production by monocytes inhibits CD4 + T cell response.", "The innate immune response struggles to remove small numbers of parasites.", "The G34R/V mutation creates a hypomethylated phenotype at the H3K36 histone.", "Mutations in RIM1 raise levels of IME1 RNA.", "Two variants of chromosome 6q21 are associated with radiation therapy-induced second malignancies in pediatric Hodgkin lymphoma patients."], "hard_negatives": ["Increased vessel density along with a reduction in fibrosis improves the efficacy of chemotherapy treatments.", "G-CSF increases the expansion and infiltration of MDSCs into tumors.", "Cancer-associated fibroblasts (CAFs) interact with cancer cells to mediate formation and activation of CAFs.", "Cancer-associated fibroblasts (CAFs) have no known interaction with cancer cells in the formation and activation of CAFs.", "AMP-activated protein kinase (AMPK) activation reduces inflammation-related fibrosis in the lungs.", "Cancer-associated fibroblasts (CAFs) are constituents of tumor microenvironments", "Inhibiting focal adhesion formation increases the rate at which cells convert mechanical strain into inflammation and fibrosis.", "The cytokine receptor which regulates chemotaxis and formation of lymph nodes is involved in production of myeloperoxidase in the left atrium.", "The tissue surrounding the granuloma in an immune cell induces an anti-inflammatory immune response.", "In breast cancer, the loss of myoepithelial cells slows the transition of ductal carcinoma in situ to invasive carcinoma."], "hard_negative": "Increased vessel density along with a reduction in fibrosis improves the efficacy of chemotherapy treatments."}
{"query_id": "621", "query_text": "Individuals with Alzheimers who participate in six months of physical activity improve cognitive function for up to 18 months.", "negative": "Patients with common epithelial cancers  are more likely to have an emergency event as their first hospital admission if they live in resource-deprived areas.", "negatives": ["Patients with common epithelial cancers  are more likely to have an emergency event as their first hospital admission if they live in resource-deprived areas.", "Pioneer factor OCT3/4 interacts with major chromatin remodeling factors.", "The HSV-2 infection is typically asymptomatic.", "The minor G allele of FOXO3 up-regulates IL-10.", "Overexpressing Cnp1 N-tail variants rescues the temperature-sensitive growth defect of scm3-139.", "Reduction of Rpl38 alters the composition of the Hox gene mRNAs translation in mice without lowering overall protein synthesis.", "Increased conversion of PGE 2 to PPARy ligand 15-ket-PGE 2 causes accumulation of PGE.", "Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission.", "4-PBA treatment decreases endoplasmic reticulum stress in response to general endoplasmic reticulum stress markers.", "taa1 tar1 tar2 triple mutants in Arabidopsis do not make root meristem during embryogenesis."], "hard_negatives": ["Individuals with Alzheimers who participate in six months of physical activity improve cognitive function for up to 18 months.", "Physical activity does not improve cognitive function in individuals with Alzheimers.", "Headaches are correlated with cognitive impairment.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have increased risk for Alzheimer's disease.", "Asymptomatic visual impairment screening in elderly populations leads to improved vision.", "Incidence of 10/66 dementia is lower than the incidence of DSM-IV dementia.", "Incidence of 10/66 dementia is higher than the incidence of DSM-IV dementia.", "In young and middle-aged adults, current or remote uses of ADHD medications increase the risk of serious cardiovascular events.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have decreased risk for dementia.", "Nonhypertensive people who are 55 years old have a 90% chance of developing hypertension during their lifetime."], "hard_negative": "Individuals with Alzheimers who participate in six months of physical activity improve cognitive function for up to 18 months."}
{"query_id": "622", "query_text": "Individuals with low serum vitamin D concentrations have decreased risk of multiple sclerosis.", "negative": "Lack of FGF21 in mice increases life expectancy.", "negatives": ["Lack of FGF21 in mice increases life expectancy.", "Deregulation of HAND2 is a crucial step in endometrial carcinogenesis in mice.", "Klf4 is not required for proper myeloid cell differentiation.", "Tirasemtiv targets cardiac muscle.", "Mice lacking Sirt1 in Sf1-expressing neurons have increased susceptibility to diet-induced obesity and insulin resistance.", "1 in 5 million in UK have abnormal PrP positivity.", "Mouse models can be generated using \"artificial spermatids.\"", "DMS3 protein enables Pol V transcription in vivo.", "MafA phosphorylation decreases its ubiquitination.", "Antiretroviral therapy increases rates of tuberculosis across a broad range of CD4 strata."], "hard_negatives": ["Individuals with low serum vitamin D concentrations have decreased risk of multiple sclerosis.", "Vitamin D deficiency effects birth weight.", "Antiretroviral therapy increases rates of tuberculosis across a broad range of CD4 strata.", "A deficiency of vitamin B12 decreases blood levels of homocysteine.", "A deficiency of folate increases blood levels of homocysteine.", "Women with a lower birth weight are more likely to develop breast cancer later in life.", "40mg/day dosage of folic acid and 2mg/day dosage of vitamin B12 does not affect chronic kidney disease (CKD) progression.", "In patients with congenital heart defects, \u03b2-blockers significantly improve clinical heart failure outcomes.", "Ten percent (10%) of kidney cancers in the UK are attributable to excess weight.", "The risk of breast cancer among parous women decreases with placental weight of pregnancies."], "hard_negative": "Individuals with low serum vitamin D concentrations have decreased risk of multiple sclerosis."}
{"query_id": "624", "query_text": "Induced hepatic stem cells possess the potential to differentiate into cholangiocytic cells.", "negative": "BiP is a general endoplasmic reticulum stress marker.", "negatives": ["BiP is a general endoplasmic reticulum stress marker.", "Traditional reviews are biased in their interpretations.", "Whole brain radiotherapy increases the occurrence of new brain metastases.", "Gastric lavage is an effective treatment for acute paraquat poisoning.", "Early patent ductus ateriosus (PDA) screening decreases in-hospital mortality.", "Roughly 55% of women with chronic pelvic pain have no underlying pathology.", "Intake of folic acid (FA) and vitamin B6 (VB6) increases levels of homocysteine.", "The removal of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells.", "The most prevalent adverse events to Semaglutide are cardiovascular.", "Sweet taste receptors on the tongue are deactivated by between 1 and 10 mM glucose."], "hard_negatives": ["Induced hepatic stem cells possess the potential to differentiate into cholangiocytic cells.", "Induced hepatic stem cells possess the potential to differentiate into hepatocytic cells.", "Cancer cells can stimulate the accumulation of intra-tumoural myeloid-derived suppressor cells by promoting granulocyte colony stimulating factor production.", "Osteocytes have an essential role in G-CSF induced HSPC mobilization.", "Differentiation of progenitor cells to myeloid cells is skewed when insulin signaling is suppressed.", "Differentiation of progenitor cells to myeloid cells is skewed upon activation of insulin signaling.", "The cytokine receptor which regulates chemotaxis and formation of lymph nodes is involved in production of myeloperoxidase in the left atrium.", "The generation of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells.", "The myocardial cell lineage originally develops from cardiac progenitors of exclusively endodermal origin.", "Activated Cdk5 regulates DNA damage-induced neuronal death."], "hard_negative": "Induced hepatic stem cells possess the potential to differentiate into cholangiocytic cells."}
{"query_id": "625", "query_text": "Induced hepatic stem cells possess the potential to differentiate into hepatocytic cells.", "negative": "The generation of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells.", "negatives": ["The generation of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells.", "In breast cancer, the loss of myoepithelial cells slows the transition of ductal carcinoma in situ to invasive carcinoma.", "Pyridostatin decreases telomere fragility in BRCA2-deficient cells.", "RANK-RANKL pathway signalling has no known association with development of Aire-expressing medullary thymic epithelial cells.", "Neutrophils produce IL-1\u03b2 in response to large particles.", "Citrullinated proteins externalized in neutrophil extracellular traps act indirectly to perpetuate the inflammatory cycle via induction of autoantibodies.", "MafA ubiquitination increases the recruitment of coavtivator P/CAF by MafA.", "Cancers that initially benefit from epidermal growth factor receptor targeted therapies later become refractory through several mechanisms.", "Cognitive behavioral therapy is an ineffective treatment for insomnia", "Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 inhibit West Nile virus replication in cortical neurons."], "hard_negatives": ["Induced hepatic stem cells possess the potential to differentiate into hepatocytic cells.", "Induced hepatic stem cells possess the potential to differentiate into cholangiocytic cells.", "Cancer cells can stimulate the accumulation of intra-tumoural myeloid-derived suppressor cells by promoting granulocyte colony stimulating factor production.", "Osteocytes have an essential role in G-CSF induced HSPC mobilization.", "Differentiation of progenitor cells to myeloid cells is skewed when insulin signaling is suppressed.", "Hematopoietic Stem Cell purification reaches purity rates above 90%.", "Specialized functional cell types can be derived from human pluripotent stem cells.", "Differentiation of progenitor cells to myeloid cells is skewed upon activation of insulin signaling.", "The myocardial cell lineage originally develops from cardiac progenitors of exclusively endodermal origin.", "Androgenetic haploid mouse embryonic stem cells (ESCs) can be derived and genetically manipulated in vitro."], "hard_negative": "Induced hepatic stem cells possess the potential to differentiate into hepatocytic cells."}
{"query_id": "626", "query_text": "Induction of urokinase receptor signaling in podocytes causes foot process effacement and proteinuria.", "negative": "Genetic deficiency of mast cells leads to decreased weight gain in a mouse model of diet-induced obesity.", "negatives": ["Genetic deficiency of mast cells leads to decreased weight gain in a mouse model of diet-induced obesity.", "ALDH1 expression is associated with poorer prognosis for breast cancer primary tumors.", "4-PBA treatment raises endoplasmic reticulum stress in response to general endoplasmic reticulum stress markers.", "Patients with microcytosis and higher erythrocyte count are more vulnerable to severe malarial anaemia when infected with Plasmodium falciparum.", "Aged patients are more susceptible to ischaemia/reperfusion injury.", "Microglia are an innate immune cell type of the central nervous system.", "Pyridostatin encourages proliferation of homologous recombination - defective cells.", "Activator-inhibitor pairs are provided ventrally by Xrl-sizzled.", "Primary pro-inflammatory cytokines suppress secondary pro- and anti-inflammatory mediators.", "The first MBT repeat of the four malignant brain tumor (4MBT) domain of Drosophila's Sfmbt and of the orthologous mammalian L3MBTL2 is required for the interaction with the spacer region of Drosophila's Pleiohomeotic (Pho) or its human ortholog YY1."], "hard_negatives": ["Induction of urokinase receptor signaling in podocytes causes foot process effacement and proteinuria.", "Osteoparthritis (OA) is characterized by degeneration of articular cartilage, joint edge, and subchondral bone hyperplasia.", "Reduced levels of lipolysis leads to higher P38 phosphorylation in adipose tissue.", "Increased lipolysis leads to higher P38 phosphorylation in adipose tissue.", "Depletion of nitric oxide is responsible for vasospasm.", "The morphology change from large white adipocytes to small brown adipocytes is a sign of decreased energy expenditure potential in white adipose tissue.", "The effect of Lipopolysaccharides on kidney barrier function is dependent on inflammation levels.", "Rhythmic expression of Cry1 translates directly into a circadian regulation of cAMP signaling in gluconeogenesis.", "The morphology change from large white adipocytes to small brown adipocytes is a sign of increased energy expenditure potential in white adipose tissue.", "An M2-like phenotype in brown adipose tissue macrophages is quickly induced by cold exposure."], "hard_negative": "Induction of urokinase receptor signaling in podocytes causes foot process effacement and proteinuria."}
{"query_id": "631", "query_text": "Inhibiting HDAC6 increases survival of mice with ARID1A mutated tumors.", "negative": "Autophagy deficiency in the liver increases vulnerability to insulin resistance.", "negatives": ["Autophagy deficiency in the liver increases vulnerability to insulin resistance.", "Risedronate increases risk of vertebral and non-vertebral fractures.", "Rotator cuff exercises are more effective than general exercise therapy in reducing pain and improving function of the shoulder.", "De novo assembly of sequence data has shorter contigs than unassembled sequence data.", "Decreased conversion of PGE 2 to PPARy ligand 15-ket-PGE 2 causes accumulation of PGE.", "Foxk2 regulates autophagy genes in muscle cells and fibroblast cells.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have longer lifetime exposure to estrogen due to an increased reproductive period.", "DUSP4 decreases apoptosis.", "Prescribed exercise training improves quality of life.", "Lack of FGF21 in mice increases life expectancy."], "hard_negatives": ["Inhibiting HDAC6 increases survival of mice with ARID1A mutated tumors.", "Reduced phosphorylation of PP2A increases HDAC4 dephosphorylation by enhancing PP2A-HDAC4 interaction.", "A deficiency of vitamin B6 decreases blood levels of homocysteine.", "Reduced phosphorylation of PP2A suppresses HDAC4 dephosphorylation.", "B3-Galectin increases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR.", "B3-Galectin decreases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR.", "Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes epithelial damage.", "ALDH1 expression is associated with poorer prognosis for breast cancer primary tumors.", "In transgenic mice harboring green florescent protein under the control of the Sox2 promoter, more than 50 percent of the cells with green florescent colocalize with cell proliferation markers.", "Mice without IFN-\u03b3 or its receptor are highly susceptible to EAM induced with \u03b1-MyHC/CFA."], "hard_negative": "Inhibiting HDAC6 increases survival of mice with ARID1A mutated tumors."}
{"query_id": "632", "query_text": "Inhibiting focal adhesion formation enables cells to convert mechanical strain into eventual scarring.", "negative": "Increased microtubule acetylation repairs interference of axonal transport caused by LRRK2 Roc-COR domain mutations.", "negatives": ["Increased microtubule acetylation repairs interference of axonal transport caused by LRRK2 Roc-COR domain mutations.", "A diminished ovarian reserve does not solely indicate infertility in an a priori non-infertile population.", "HNF4A mutations are associated with macrosomia in infancy.", "Addition of BMP4, activin A, CHIR99021, and SU504 to reprogramming fibroblasts generates, expands and maintains cardiovascular progenitor cells (CPCs)", "Lack of FGF21 in mice slows the rate of atherosclerotic plaque formation.", "RANK-RANKL pathway signalling is linked to development of Aire-expressing medullary thymic epithelial cells.", "A diminished ovarian reserve does not solely indicate infertility in an a priori non-infertile population.", "Mice that lack Interferon-\u03b3 or its receptor are highly susceptible to experimental autoimmune myocarditis.", "Increased LDL receptors plays a role in the reduction of plasma Lp(a).", "The PRR MDA5 has a C-terminal domain."], "hard_negatives": ["Inhibiting focal adhesion formation enables cells to convert mechanical strain into eventual scarring.", "Inhibiting focal adhesion formation increases the rate at which cells convert mechanical strain into inflammation and fibrosis.", "Myelin sheaths play a role in action potential propagation.", "The microtubule-dependent delivery and secretion of matrix metalloproteases (MMPs) is partially responsible for the disassembly of adhesion sites.", "Tuberculosis-induced granulomas express different immune system protein signatures than the surrounding tissue.", "The tissue surrounding the granuloma in an immune cell induces an anti-inflammatory immune response.", "Flexible molecules experience less steric hindrance in the tumor microenviroment than rigid molecules.", "Glioblastoma multiforme (GBM) is characterized by extensive invasion, rapid growth, necrosis, and angiogenesis.", "Lamins have no effect on nuclear membrane structure maintenance.", "Cancer-associated fibroblasts (CAFs) interact with cancer cells to mediate formation and activation of CAFs."], "hard_negative": "Inhibiting focal adhesion formation enables cells to convert mechanical strain into eventual scarring."}
{"query_id": "633", "query_text": "Inhibiting focal adhesion formation increases the rate at which cells convert mechanical strain into inflammation and fibrosis.", "negative": "A deficiency of vitamin B6 decreases blood levels of homocysteine.", "negatives": ["A deficiency of vitamin B6 decreases blood levels of homocysteine.", "Mitochondria play a major role in apoptosis.", "Intramembrane cleavage by signal peptide peptidase aids in the degradation of proteins with a complex membrane orientation.", "Pure neural progenitor cell (NPC) populations can only be obtained from cell cultures that undergo passaging, filtration, or other isolation and cell sorting methods.", "Carriers of HNF4A mutations are at reduced risk for diabetes.", "Continued HHV-8 transmission among MSM in San Francisco may be explained by urogenital contact.", "Gpr124 increases BBB breakdown in mouse models of ischemic stroke.", "Removal of H3K9me3 improves reprogramming efficiency in human somatic cell nuclear transfer experiments.", "H4 G94P proteins suppress degradation of free histones via Rad53-dependent mechanisms.", "Oxidative DNA damage activates STING signalling."], "hard_negatives": ["Inhibiting focal adhesion formation increases the rate at which cells convert mechanical strain into inflammation and fibrosis.", "Inhibiting focal adhesion formation enables cells to convert mechanical strain into eventual scarring.", "Cancer-associated fibroblasts (CAFs) interact with cancer cells to mediate formation and activation of CAFs.", "The tissue surrounding the granuloma in an immune cell induces an anti-inflammatory immune response.", "Cancer-associated fibroblasts (CAFs) have no known interaction with cancer cells in the formation and activation of CAFs.", "Tuberculosis-induced granulomas express different immune system protein signatures than the surrounding tissue.", "Myelin sheaths play a role in action potential propagation.", "Increased vessel density along with a reduction in fibrosis improves the efficacy of chemotherapy treatments.", "The microtubule-dependent delivery and secretion of matrix metalloproteases (MMPs) is partially responsible for the disassembly of adhesion sites.", "Citrullinated proteins externalized in neutrophil extracellular traps act indirectly to disrupt the inflammatory cycle."], "hard_negative": "Inhibiting focal adhesion formation increases the rate at which cells convert mechanical strain into inflammation and fibrosis."}
{"query_id": "635", "query_text": "Inhibiting glucose-6-phospate dehydrogenase improves lipogenesis by deactivating LKB1-AMPK signaling.", "negative": "Obesity raises life quality.", "negatives": ["Obesity raises life quality.", "HOXB4 facilitates HSC expansion when co-cultured with HSCs.", "N348I mutations cause resistance to nevirapine.", "The density of cytokine receptor bearing cells has no effect on the distance over which cytokines act.", "Mutations in RIM1 raise levels of IME1 RNA.", "Charcoal shows no benefit for acute paraquat poisoning.", "TNFAIP3 is a glioblastoma tumor suppressor.", "Lack of FGF21 in mice increases life expectancy.", "Folate and vitamin B12 levels influence the association between homocysteine and preeclampsia.", "Cytochrome c is transferred from cytosol to the mitochondrial intermembrane space during apoptosis."], "hard_negatives": ["Inhibiting glucose-6-phospate dehydrogenase improves lipogenesis by deactivating LKB1-AMPK signaling.", "Increased lipolysis leads to higher P38 phosphorylation in adipose tissue.", "Reduced levels of lipolysis leads to higher P38 phosphorylation in adipose tissue.", "C2 works synergistically with A-769662 to activate dephosphorylated AMPK.", "PCSK9 inhibitors decrease plasma Lp(a) levels.", "AMP-activated protein kinase (AMPK) activation reduces inflammation-related fibrosis in the lungs.", "Removal of H3K9me3 by ectopic expression of other H3K9 demethylases improves reprogramming efficiency in SCNT experiments.", "Reduced phosphorylation of PP2A increases HDAC4 dephosphorylation by enhancing PP2A-HDAC4 interaction.", "Removal of H3K9me3 by ectopic expression of other H3K9 demethylases decreases reprogramming efficiency in SCNT experiments.", "Upregulation of PD1 causes the upregulation of Satb1."], "hard_negative": "Inhibiting glucose-6-phospate dehydrogenase improves lipogenesis by deactivating LKB1-AMPK signaling."}
{"query_id": "638", "query_text": "Input from  mental and physical health care professionals is not effective at decreasing homelessness.", "negative": "Pioglitazone use is not associated with an increased risk of prostate cancer.", "negatives": ["Pioglitazone use is not associated with an increased risk of prostate cancer.", "Converting apoE4 to apoE3 by gene editing worsens the pathology associated with apoE4 in human iPSCderived neurons.", "BiP is a general endoplasmic reticulum stress marker.", "Differentiation of progenitor cells to myeloid cells is skewed when insulin signaling is suppressed.", "Differentiation of progenitor cells to myeloid cells is skewed when insulin signaling is suppressed.", "Varying expression levels of EBI2 affect the positioning and migration of B cells.", "Environmental factors can influence the development of breast cancer.", "TMEM27 is a marker for beta cells.", "In S. cerevisiae, the absence of RNA surveillance pathways reduces sensitivity to high iron conditions.", "Gastric lavage is an effective treatment for acute paraquat poisoning."], "hard_negatives": ["Input from  mental and physical health care professionals is not effective at decreasing homelessness.", "Self-advocacy training is effective at decreasing homelessness.", "Integrated care is ineffective at tackling multiple comorbidities.", "Integrated care is successful at tackling multiple comorbidities.", "76-85% of people with severe mental disorder receive no treatment in low and middle income countries.", "In young and middle-aged adults, current or remote uses of ADHD medications increase the risk of serious cardiovascular events.", "Bariatric surgery leads to negative outcomes in mental health.", "Assessing treatment adherence is more beneficial to clinical practice than measuring routine outcomes.", "Bariatric surgery leads to positive outcomes in mental health.", "Walking in traffic areas in London improves lung function in elderly adults."], "hard_negative": "Input from  mental and physical health care professionals is not effective at decreasing homelessness."}
{"query_id": "640", "query_text": "Inside the body, falciparum parasites reproduce asexually.", "negative": "Enhanced early production of inflammatory chemokines damages viral control in the lung.", "negatives": ["Enhanced early production of inflammatory chemokines damages viral control in the lung.", "Antimicrobial agents are more effective due to the pressure of antimicrobial usage.", "Vaccinating the gastrointestinal tract induces protection of rectal and vaginal mucosa.", "Omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegetarians.", "cSMAC formation represses weak ligand signalling.", "Commelina yellow mottle virus (ComYMV) has three typical badnavirus ORFs, capable of encoding proteins 23, 15, and 216 kD.", "Long chain polyunsaturated fatty acids supplementation is associated with lower rates of atopic eczema at 1 year.", "50% of patients exposed to radiation have activated markers of mesenchymal stem cells.", "The number of unfertilized oocytes in mated hermaphrodites increases with age.", "Adult tissue-resident macrophages stem from the embryonal yolk sac and fetal liver."], "hard_negatives": ["Inside the body, falciparum parasites reproduce asexually.", "The innate immune response struggles to remove small numbers of parasites.", "Nonhuman primates are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.", "Mice are incapable of producing neutralizing antibodies in reponse to the Chikungunya virus (CHIKV) produced in mosquitos.", "Eilat virus (EILV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in nonhuman primates.", "Tuberculosis-induced granulomas express different immune system protein signatures than the surrounding tissue.", "Anthrax spores are very difficult to dispose once they are dispersed.", "Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection increases dissemination of Salmonella Typhimurium from the gut.", "Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection decreases dissemination of Salmonella Typhimurium from the gut.", "Microglia are an innate immune cell type of the peripheral nervous system."], "hard_negative": "Inside the body, falciparum parasites reproduce asexually."}
{"query_id": "642", "query_text": "Insulin decreases risk of severe kidney failure.", "negative": "COPI coatmer is involved in lipid homeostasis.", "negatives": ["COPI coatmer is involved in lipid homeostasis.", "Enhanced early production of inflammatory chemokines damages viral control in the lung.", "BRCA 1 mutation carriers' risk of breast and ovarian cancer depends on where the mutation is located.", "Dscam1 acts as a hypervariable pattern-recognition receptor for the immune system.", "Physical injury represses transgultaminase activity.", "Vitamin D deficiency effects birth weight.", "Klf4 is not required for proper myeloid cell differentiation.", "Increased mobility of retrotransposons is assosciated with mutation and higher tumorigenesis rates.", "eRNAs influence is linked to senescence, aging, and carcinogenesis.", "Bariatric surgery leads to positive outcomes in mental health."], "hard_negatives": ["Insulin decreases risk of severe kidney failure.", "Autophagy deficiency in the liver increases vulnerability to insulin resistance.", "Angiotensin converting enzyme inhibitors are associated with decreased risk for functional renal insufficiency.", "40mg/day dosage of folic acid and 2mg/day dosage of vitamin B12 does not affect chronic kidney disease (CKD) progression.", "Medications to treat obesity do not have side effects.", "Risk of cardiovascular events can be cut by a third by using antihypertensive drug therapy among hemodialysis patients.", "Sudden death can occur in patients with orthostatic hypertension without cardiac conduction abnormalities.", "Ambulatory blood pressure monitoring is inaccurate at diagnosing hypertension.", "Medications to treat obesity have unwanted side effects.", "Diabetes remission occurs less in people treated with conventional therapy than in people treated with laparoscopic adjustable gastric banding surgery."], "hard_negative": "Insulin decreases risk of severe kidney failure."}
{"query_id": "643", "query_text": "Insulin effects appetite via ventral tegmental neurons.", "negative": "Distant CREs are less conserved among species.", "negatives": ["Distant CREs are less conserved among species.", "Migraine with aura is associated with ischemic stroke.", "Prescribed exercise training improves quality of life.", "Taking 400mg of \u03b1-tocopheryl acetate in combination with vitamin C reduces the risk of prostate cancer.", "Up-regulation of the p53 pathway and related molecular events speeds cancer progression.", "Exercise increases cancer mortality rates among Chinese citizens.", "HSCT-T dosage may not be diagnostic if the onset of symptoms occurs less than 3 hours before AMI.", "Mice without IFN-\u03b3 or its receptor are highly susceptible to EAM induced with \u03b1-MyHC/CFA.", "HIV trans-activator protein (TAT) effectively transports large and small molecules across cellular membranes into larger populations of neurons.", "Mice defective for deoxyribonucleic acid (DNA) polymerase I (polI) fail to reveal increased sensitivity to ionizing radiation (IR)."], "hard_negatives": ["Insulin effects appetite via ventral tegmental neurons.", "Autophagy deficiency in the liver increases vulnerability to insulin resistance.", "Hypothalamic glutamate neurotransmission is unrelated to energy balance.", "Energy balance requires hypothalamic glutamate neurotransmission.", "Differentiation of progenitor cells to myeloid cells is skewed upon activation of insulin signaling.", "Mice lacking Sirt1 in Sf1-expressing neurons have increased susceptibility to diet-induced obesity and insulin resistance.", "Differentiation of progenitor cells to myeloid cells is skewed when insulin signaling is suppressed.", "Foxk2 regulates autophagy genes in muscle cells and fibroblast cells.", "The proliferative capacity of neural progenitors differs across species.", "Mice lacking Sirt1 in Sf1-expressing neurons are immune to diet-induced obesity and insulin resistance."], "hard_negative": "Insulin effects appetite via ventral tegmental neurons."}
{"query_id": "645", "query_text": "Intake of folic acid (FA) and vitamin B6 (VB6) increases levels of homocysteine.", "negative": "p16INK4A degradation is  linked to an abnormal wound response caused by the microinvasive step of advanced Oral Potentially Malignant Lesions (OPMLs).", "negatives": ["p16INK4A degradation is  linked to an abnormal wound response caused by the microinvasive step of advanced Oral Potentially Malignant Lesions (OPMLs).", "HbA1c consistently overestimates glycemic control in black individuals with Sickle cell trait (SCT).", "Pediatric SCD patients with vaso-occlusive crisis show increased morphine use after breathing 80 ppm iNO for 4 hours.", "CCL19 is a ligand for CCR7.", "Nuclear transfer from adult human fibroblasts to human oocytes can give rise to blastocysts containing expandable pluripotent cells.", "Ethanol stress increases the expression of SRL in bacteria.", "Forkhead 0 (fox0) transcription factors are involved in cellular differentiation.", "Emodin forms hydrogen bonds with residues involved in PGAM1 substrate binding.", "Primary pro-inflammatory cytokines suppress secondary pro- and anti-inflammatory mediators.", "Chinese individuals with TT homozygosity in the MTHFR gene are less vulnerable to strokes caused by low levels of folate intake."], "hard_negatives": ["Intake of folic acid (FA) and vitamin B6 (VB6) increases levels of homocysteine.", "Intake of folic acid (FA) and vitamin B6 (VB6) reduces levels of homocysteine.", "A deficiency of folate increases blood levels of homocysteine.", "A deficiency of vitamin B6 decreases blood levels of homocysteine.", "A deficiency of vitamin B12 decreases blood levels of homocysteine.", "Vitamin D is an important factor in the relationship between calcium and parathyroid hormone.", "LDL cholesterol has a causal role in the development of cardiovascular disease.", "Folate and vitamin B12 levels influence the association between homocysteine and preeclampsia.", "Chinese individuals with TT homozygosity in the MTHFR gene are more vulnerable to strokes caused by low levels of folate intake.", "40mg/day dosage of folic acid and 2mg/day dosage of vitamin B12 does not affect chronic kidney disease (CKD) progression."], "hard_negative": "Intake of folic acid (FA) and vitamin B6 (VB6) increases levels of homocysteine."}
{"query_id": "646", "query_text": "Intake of folic acid (FA) and vitamin B6 (VB6) reduces levels of homocysteine.", "negative": "In domesticated populations of Saccharomyces cerevisiae, segmental aneuploidy occurs infrequently.", "negatives": ["In domesticated populations of Saccharomyces cerevisiae, segmental aneuploidy occurs infrequently.", "ER-localized phosphatase Sac1 processes PI4P through coordination with OSBP and the endosome-localized protein sorting nexin 2.", "TRAP+ osteoclasts regulate mature osteoblast maintenance.", "High levels of CRP lead to a higher risk of exacerbations in chronic obstructive pulmonary disease (COPD).", "Stiff substrates inhibit mesodermal differentiation by degrading beta-catenin in an integrin-dependent manner.", "The most prevalent adverse events to Semaglutide are gastrointestinal.", "During non-homologous end joining, the ligation step is not as tolerant of disrepairs and other distortions when joining 5' of strand breaks as compared to 3' strand breaks.", "KLF4 is necessary for VSMCs to gain genetic characteristics of other cell types within atherosclerotic lesions.", "B cells go though plasmablast differentiation and antibody production by continuous expression of EBI2.", "Overexpressing Cnp1 N-tail variants exacerbates the temperature-sensitive growth defect of scm3-139."], "hard_negatives": ["Intake of folic acid (FA) and vitamin B6 (VB6) reduces levels of homocysteine.", "Intake of folic acid (FA) and vitamin B6 (VB6) increases levels of homocysteine.", "A deficiency of folate increases blood levels of homocysteine.", "A deficiency of vitamin B6 decreases blood levels of homocysteine.", "A deficiency of vitamin B12 decreases blood levels of homocysteine.", "Vitamin D is an important factor in the relationship between calcium and parathyroid hormone.", "LDL cholesterol has a causal role in the development of cardiovascular disease.", "Folate and vitamin B12 levels influence the association between homocysteine and preeclampsia.", "Chinese individuals with TT homozygosity in the MTHFR gene are more vulnerable to strokes caused by low levels of folate intake.", "Chinese individuals with TT homozygosity in the MTHFR gene are less vulnerable to strokes caused by low levels of folate intake."], "hard_negative": "Intake of folic acid (FA) and vitamin B6 (VB6) reduces levels of homocysteine."}
{"query_id": "647", "query_text": "Integrated care is ineffective at tackling multiple comorbidities.", "negative": "Antiretroviral therapy increases rates of tuberculosis across a broad range of CD4 strata.", "negatives": ["Antiretroviral therapy increases rates of tuberculosis across a broad range of CD4 strata.", "APOE4 expression in iPSC-derived neurons results in decreased tau phosphorylation.", "KLF4 is necessary for VSMCs to gain genetic characteristics of other cell types within atherosclerotic lesions.", "Pioneer factor OCT3/4 interacts with major chromatin remodeling factors.", "Lamins have no effect on nuclear membrane structure maintenance.", "During non-homologous end joining, the ligation step is not as tolerant of disrepairs and other distortions when joining 5' of strand breaks as compared to 3' strand breaks.", "Perigenital skin is not the primary site of HIV acquisition.", "Sildenafil worsens erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.", "Helicobacter pylori-induced aberrant NF-kB-dependent expression of activation-induced cytidine deaminase contributes to the mutagenesis of host DNA.", "Women are more susceptible to death due to pneumonia when compared to men."], "hard_negatives": ["Integrated care is ineffective at tackling multiple comorbidities.", "Integrated care is successful at tackling multiple comorbidities.", "Assessing treatment adherence is more beneficial to clinical practice than measuring routine outcomes.", "Input from  mental and physical health care professionals is not effective at decreasing homelessness.", "Measuring routine outcomes is more beneficial to clinical practice than assessing treatment adherence.", "Self-advocacy training is effective at decreasing homelessness.", "Cost effectiveness evaluations based on cRCT data accurately reflect prices for patients in actual clinical practice.", "Cost effectiveness evaluations based on cRCT data lack external validity.", "Asymptomatic visual impairment screening in elderly populations leads to improved vision.", "Integrating classroom-based collaborative learning with Web-based collaborative learning offers the best class performance."], "hard_negative": "Integrated care is ineffective at tackling multiple comorbidities."}
{"query_id": "648", "query_text": "Integrated care is successful at tackling multiple comorbidities.", "negative": "Scapular stabilizer exercises are more effective than general exercise therapy in reducing pain and improving function of the shoulder.", "negatives": ["Scapular stabilizer exercises are more effective than general exercise therapy in reducing pain and improving function of the shoulder.", "Replacement of histone H2A with H2A.Z accelerates gene activation in yeasts by destabilizing +1 nucleosomes.", "TRAP+ osteoclasts regulate mature osteoblast maintenance.", "Assessing treatment adherence is more beneficial to clinical practice than measuring routine outcomes.", "Microglia are an innate immune cell type of the central nervous system.", "A 100g dose of chloroquine chemoprophylactic regimen results in retinal toxicity after 1 year of weekly intake.", "Egr3 regulates the homeostasis of B and T cells.", "Metastatic colorectal cancer treated with a single agent fluoropyrimidines resulted in similar efficacy and better quality of life when compared with oxaliplatin-based chemotherapy in elderly patients.", "The risk of female prisoners harming themselves is ten times that of male prisoners.", "The DESMOND program demonstrates no significant impact on biochemical outcomes."], "hard_negatives": ["Integrated care is successful at tackling multiple comorbidities.", "Integrated care is ineffective at tackling multiple comorbidities.", "Self-advocacy training is effective at decreasing homelessness.", "Assessing treatment adherence is more beneficial to clinical practice than measuring routine outcomes.", "Input from  mental and physical health care professionals is not effective at decreasing homelessness.", "Measuring routine outcomes is more beneficial to clinical practice than assessing treatment adherence.", "Integrating classroom-based collaborative learning with Web-based collaborative learning offers the best class performance.", "Cost effectiveness evaluations based on cRCT data accurately reflect prices for patients in actual clinical practice.", "Risk-adjusted mortality rates are similar in teaching and non-teaching hospitals.", "Bariatric surgery leads to positive outcomes in mental health."], "hard_negative": "Integrated care is successful at tackling multiple comorbidities."}
{"query_id": "650", "query_text": "Integrating classroom-based collaborative learning with Web-based collaborative learning offers the best class performance.", "negative": "B cells go though plasmablast differentiation and antibody production by continuous expression of EBI2.", "negatives": ["B cells go though plasmablast differentiation and antibody production by continuous expression of EBI2.", "Homozygous deletion of murine Sbds gene from osterix-expressing mesenchymal stem and progenitor cells (MPCs) induces oxidative stress.", "Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 encourage West Nile virus replication in cortical neurons.", "Immune responses in immune cells are geographically segregated.", "Long - range chromatin interactions regulate transcription.", "Omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegetarians.", "There is no relation between Erythromycin use and hypertrophic pyloric stenosis.", "Overexpressing Cnp1 N-tail variants exacerbates the temperature-sensitive growth defect of scm3-139.", "The composition of myosin-II isoform switches from the A isoform to the B isoform during hematopoietic differentiation.", "Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 encourage West Nile virus replication in cortical neurons."], "hard_negatives": ["Integrating classroom-based collaborative learning with Web-based collaborative learning offers the best class performance.", "Integrated care is successful at tackling multiple comorbidities.", "Integrated care is ineffective at tackling multiple comorbidities.", "Measuring routine outcomes is more beneficial to clinical practice than assessing treatment adherence.", "Cost effectiveness evaluations based on cRCT data lack external validity.", "Self-advocacy training is effective at decreasing homelessness.", "Assessing treatment adherence is more beneficial to clinical practice than measuring routine outcomes.", "Cost effectiveness evaluations based on cRCT data accurately reflect prices for patients in actual clinical practice.", "Having a main partner improves HIV outcomes.", "7-day-old adult Caenorhabditis elegans exhibit approximately 75% of the learning capacity seen in 1-day old adults."], "hard_negative": "Integrating classroom-based collaborative learning with Web-based collaborative learning offers the best class performance."}
{"query_id": "651", "query_text": "Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 encourage West Nile virus replication in cortical neurons.", "negative": "Lice attenuated SIV vaccines induce a stronger antigen-specific T cell response in lymph node cells.", "negatives": ["Lice attenuated SIV vaccines induce a stronger antigen-specific T cell response in lymph node cells.", "Autophagy deficiency in the liver increases vulnerability to insulin resistance.", "Insulin decreases risk of severe kidney failure.", "Inhibiting focal adhesion formation increases the rate at which cells convert mechanical strain into inflammation and fibrosis.", "V-9302 inhibits antitumor responses by decreasing cell death and oxidative stress.", "Chinese individuals with TT homozygosity in the MTHFR gene are less vulnerable to strokes caused by low levels of folate intake.", "Early patent ductus ateriosus (PDA) screening increases in-hospital mortality.", "FACT and other histone chaperone(s) compensate for Histone 2A (H2A)-histone 2B (H2B) dimer eviction during the histone exchange process.", "Kir7.1 modulates channel activity by the G protein-coupled melanocortin-4 receptor (MC4R) in the paraventricular nucleus of the hypothalamus.", "A high microerythrocyte count protects against severe anemia in homozygous alpha (+)- thalassemia trait subjects."], "hard_negatives": ["Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 encourage West Nile virus replication in cortical neurons.", "Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 inhibit West Nile virus replication in cortical neurons.", "Eilat virus (EILV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in nonhuman primates.", "Nonhuman primates are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.", "The deamination of cytidine to uridine on the minus strand of viral DNA can inactivate the viral genome by inducing G-to-A mutations.", "The latent infection of myeloid cells with human cytomegalovirus induces a number of changes in gene expression.", "Commelina yellow mottle virus (ComYMV) has three typical badnavirus ORFs, capable of encoding proteins 23, 15, and 216 kD.", "Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection decreases dissemination of Salmonella Typhimurium from the gut.", "Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection increases dissemination of Salmonella Typhimurium from the gut.", "Neutrophils produce IL-1\u03b2 in response to large particles."], "hard_negative": "Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 encourage West Nile virus replication in cortical neurons."}
{"query_id": "652", "query_text": "Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 inhibit West Nile virus replication in cortical neurons.", "negative": "Oxidative DNA damage activates STING signalling.", "negatives": ["Oxidative DNA damage activates STING signalling.", "0-dimensional biomaterials lack inductive properties.", "ART has no effect on the infectiveness of HIV-positive people.", "Systemic lupus erythematosus is a risk factor for cardiovascular disease.", "COPI coatmer is involved in viral replication.", "Rhythmic expression of Cry1 translates directly into a circadian regulation of cAMP signaling in hepatic glucose metabolism.", "Major antigen-induced signals from the T cell receptor and secondary signals from costimulatory receptors are required for T cell activation.", "Participants who quit smoking reduce lung cancer risk by approximately 50%.", "Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 encourage West Nile virus replication in cortical neurons.", "Phase information is useful for predicting donor-recipient matches in organ transplantation."], "hard_negatives": ["Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 inhibit West Nile virus replication in cortical neurons.", "Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 encourage West Nile virus replication in cortical neurons.", "Eilat virus (EILV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in nonhuman primates.", "Nonhuman primates are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.", "The deamination of cytidine to uridine on the minus strand of viral DNA can inactivate the viral genome by inducing G-to-A mutations.", "The latent infection of myeloid cells with human cytomegalovirus induces a number of changes in gene expression.", "Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection decreases dissemination of Salmonella Typhimurium from the gut.", "Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection increases dissemination of Salmonella Typhimurium from the gut.", "Commelina yellow mottle virus (ComYMV) has three typical badnavirus ORFs, capable of encoding proteins 23, 15, and 216 kD.", "Bacteriophagaes MS2 and Q\u03b2 are members of the Leviviridae."], "hard_negative": "Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 inhibit West Nile virus replication in cortical neurons."}
{"query_id": "653", "query_text": "Interleukin-18 plays an important role in the pathogenesis of atherosclerosis.", "negative": "A deficiency of folate increases blood levels of homocysteine.", "negatives": ["A deficiency of folate increases blood levels of homocysteine.", "In S. cerevisiae, the absence of RNA surveillance pathways reduces sensitivity to high iron conditions.", "HIV trans-activator protein (TAT) effectively transports large and small molecules across cellular membranes into larger populations of neurons.", "Stroke patients with prior use of direct oral anticoagulants have a higher risk of in-hospital mortality than stroke patients with prior use of warfarin.", "Walking in traffic areas in London did not improve lung function in elderly adults.", "H4 G94P proteins induce degradation of free histones via Rad53-dependent mechanisms.", "Having a main partner worsens HIV outcomes.", "Rapamycin delays aging in fruit flies.", "General exercise therapy is more effective than rotator cuff exercises in reducing pain and improving function of the shoulder.", "LRBA promotes CTLA - 4 recycling."], "hard_negatives": ["Interleukin-18 plays an important role in the pathogenesis of atherosclerosis.", "Repressing IL-18 has negative effects on atherosclerotic lesion composition and progression.", "Reduced responsiveness to interleukin-2 in regulatory T cells is associated with autoimmune diseases such as Type 1 Diabetes.", "IL-6 signaling plays a major role in atherosclerotic cardiovascular disease.", "p16INK4A degradation is  linked to an abnormal wound response caused by the microinvasive step of advanced Oral Potentially Malignant Lesions (OPMLs).", "KRT17 modulates the expression of the transcriptional regulator AIRE in diseased epithelia.", "The NF-\u03baB essential modulator gene induces intestinal inflammation by promoting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death.", "Osteoparthritis (OA) is characterized by degeneration of articular cartilage, joint edge, and subchondral bone hyperplasia.", "The NF-\u03baB essential modulator gene prevents intestinal inflammation by inhibiting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death.", "Two variants of chromosome 6q21 are associated with radiation therapy-induced second malignancies in pediatric Hodgkin lymphoma patients."], "hard_negative": "Interleukin-18 plays an important role in the pathogenesis of atherosclerosis."}
{"query_id": "654", "query_text": "Intra-cerebroventricular infusion of amyloid-\u03b2 oligomers increases expression of fibronectin type-III domain-containing protein 5 mRNA in mice hippocampi.", "negative": "Mice that lack Interferon-\u03b3 or its receptor are highly susceptible to experimental autoimmune myocarditis.", "negatives": ["Mice that lack Interferon-\u03b3 or its receptor are highly susceptible to experimental autoimmune myocarditis.", "Increase of p62 in prostate tumor stroma results in defective autophagy.", "AMP-activated protein kinase (AMPK) activation reduces inflammation-related fibrosis in the lungs.", "Tirasemtiv targets cardiac muscle.", "Natriuretic peptides protect against diabetes.", "Asymptomatic visual impairment screening in elderly populations leads to improved vision.", "Physical activity level has no association with the difference in maximal oxygen consumption between black and white youth.", "Clathrin stabilizes the spindle fiber apparatus during mitosis.", "Normal granulomas form in the presence of TNF in Zebrafish.", "Decreased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm."], "hard_negatives": ["Intra-cerebroventricular infusion of amyloid-\u03b2 oligomers increases expression of fibronectin type-III domain-containing protein 5 mRNA in mice hippocampi.", "Intra-cerebroventricular infusion of amyloid-\u03b2 oligomers reduces expression of fibronectin type-III domain-containing protein 5 mRNA in mice hippocampi.", "Guanine nucleotide exchange factors (GEFs) mediate RhoA activation in response to tensional forces on fibronectin-binding integrins.", "Upregulation of dynein in Drosophila neurons increases the number of microtubule plus-ends growing toward the cell body of each neuron.", "Fibroblast growth factor 21 protects against atherosclerosis by modulating adiponectin and SREBP2 levels.", "Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes fibrosis.", "Gpr124 increases BBB breakdown in mouse models of ischemic stroke.", "The C-type lectin receptor (CLEC-2) rearranges the actin cytoskeleton in dendritic cells to promote efficient motility along stromal surfaces.", "IL-6 signaling plays a major role in atherosclerotic cardiovascular disease.", "Inhibiting glucose-6-phospate dehydrogenase improves lipogenesis by deactivating LKB1-AMPK signaling."], "hard_negative": "Intra-cerebroventricular infusion of amyloid-\u03b2 oligomers increases expression of fibronectin type-III domain-containing protein 5 mRNA in mice hippocampi."}
{"query_id": "655", "query_text": "Intra-cerebroventricular infusion of amyloid-\u03b2 oligomers reduces expression of fibronectin type-III domain-containing protein 5 mRNA in mice hippocampi.", "negative": "Dscam1 acts as a hypervariable pattern-recognition receptor for the immune system.", "negatives": ["Dscam1 acts as a hypervariable pattern-recognition receptor for the immune system.", "T cell receptor /CD3 microdomains are required to induce the immunologic synapse.", "CDK6 shows improved binding to loss-of-function variants of p18 INK4C.", "The gene daf-16, which encodes forkhead Box O (FOXO), is required for all phenotypes associated with reduced insulin/insulin-like growth factor (Igf) signaling.", "Sudden death can occur in patients with complex ventricular arrhythmias.", "Birth-weight is negatively associated with breast cancer.", "Reduced phosphorylation of PP2A suppresses HDAC4 dephosphorylation.", "The mean suicide rate in women is higher after miscarriage than live birth.", "Natriuretic peptides increase susceptibility to diabetes.", "Removal of H3K9me3 by ectopic expression of other H3K9 demethylases decreases reprogramming efficiency in SCNT experiments."], "hard_negatives": ["Intra-cerebroventricular infusion of amyloid-\u03b2 oligomers reduces expression of fibronectin type-III domain-containing protein 5 mRNA in mice hippocampi.", "Intra-cerebroventricular infusion of amyloid-\u03b2 oligomers increases expression of fibronectin type-III domain-containing protein 5 mRNA in mice hippocampi.", "Guanine nucleotide exchange factors (GEFs) mediate RhoA activation in response to tensional forces on fibronectin-binding integrins.", "Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes fibrosis.", "Gpr124 increases BBB breakdown in mouse models of ischemic stroke.", "Upregulation of dynein in Drosophila neurons increases the number of microtubule plus-ends growing toward the cell body of each neuron.", "Gpr124 suppresses BBB breakdown in mouse models of ischemic stroke.", "IL-6 signaling plays a major role in atherosclerotic cardiovascular disease.", "Inhibiting glucose-6-phospate dehydrogenase improves lipogenesis by deactivating LKB1-AMPK signaling.", "Fibroblast growth factor 21 protects against atherosclerosis by modulating adiponectin and SREBP2 levels."], "hard_negative": "Intra-cerebroventricular infusion of amyloid-\u03b2 oligomers reduces expression of fibronectin type-III domain-containing protein 5 mRNA in mice hippocampi."}
{"query_id": "657", "query_text": "Intramembrane cleavage by signal peptide peptidase aids in the degradation of proteins with a complex membrane orientation.", "negative": "High levels of CRP lead to a higher risk of exacerbations in chronic obstructive pulmonary disease (COPD).", "negatives": ["High levels of CRP lead to a higher risk of exacerbations in chronic obstructive pulmonary disease (COPD).", "BiP is a general endoplasmic reticulum stress marker.", "There was an estimated 30 million cases of pneumonia in young children worldwide in 2010.", "Two variants of chromosome 6q21 are associated with radiation therapy-induced second malignancies in pediatric Hodgkin lymphoma patients.", "The HSV-2 infection is typically asymptomatic.", "Trans-acting factors, such as lncRNAs, influence mRNA translation.", "Having a main partner worsens HIV outcomes.", "Mice without IFN-\u03b3 or its receptor are highly susceptible to EAM induced with \u03b1-MyHC/CFA.", "Surfactin producing cells and exopolymer producing cells cooperate to generate \"Van Gogh\" bundles that have sliding abilities on specialized media.", "Klf4 is important for proper myeloid cell differentiation."], "hard_negatives": ["Intramembrane cleavage by signal peptide peptidase aids in the degradation of proteins with a complex membrane orientation.", "Many transmembrane receptors transmit signals by long-range conformational changes in the association of alpha-helices across the plasma membrane.", "The microtubule-dependent delivery and secretion of matrix metalloproteases (MMPs) is partially responsible for the disassembly of adhesion sites.", "Ly49Q directs the organization of neutrophil polarization by regulating membrane raft functions.", "VgrG (Tssl) protein punctures membranes by forming a spike at the tip of the tube apparatus.", "Stiff substrates encourage mesodermal differentiation by degrading beta-catenin in an integrin-dependent manner.", "Lamins have no effect on nuclear membrane structure maintenance.", "r-protein chaperones are found in complexes with their r-protein binding partners.", "Lamins are associated with nuclear membrane structure maintenance.", "Reduction of purity of cytoplasmic membranes isolated from overexpressors is indicated by stronger spots for OmpA in 2D BN-PAGE gels."], "hard_negative": "Intramembrane cleavage by signal peptide peptidase aids in the degradation of proteins with a complex membrane orientation."}
{"query_id": "658", "query_text": "It is not proven that moderate consumption of candy and chocolate reduces the risk of cardiovascular disease (CVD) specifically.", "negative": "Environmental factors can influence the development of breast cancer.", "negatives": ["Environmental factors can influence the development of breast cancer.", "r-protein chaperones are found in complexes with their r-protein binding partners.", "Tonic signaling from the scFv is amplified by MyD88/CD40.", "Bariatric surgery reduces colorectal cancer.", "ATF4 is a general endoplasmic reticulum stress marker.", "Gastric lavage is an effective treatment for acute paraquat poisoning.", "Sequence conservation in gene regulatory regions between species is a poor predictor of conserved functionality.", "Ribosomopathies have a high degree of cell and tissue specific pathology.", "In S. cerevisiae, the absence of RNA surveillance pathways reduces sensitivity to high iron conditions.", "Physical activity does not improve cognitive function in individuals with Alzheimers."], "hard_negatives": ["It is not proven that moderate consumption of candy and chocolate reduces the risk of cardiovascular disease (CVD) specifically.", "Moderate consumption of candy and chocolate reduces the risk of cardiovascular disease (CVD).", "Consumption of whole fruits increases the risk of type 2 diabetes.", "Taxation of sugar-sweetened beverages reduced the incidence rate of type II diabetes in India.", "Medications to treat obesity have unwanted side effects.", "LDL cholesterol has a causal role in the development of cardiovascular disease.", "Medications to treat obesity do not have side effects.", "In young and middle-aged adults, current or remote uses of ADHD medications increase the risk of serious cardiovascular events.", "Autophagy deficiency in the liver increases vulnerability to insulin resistance.", "Medications to treat obesity are highly effective."], "hard_negative": "It is not proven that moderate consumption of candy and chocolate reduces the risk of cardiovascular disease (CVD) specifically."}
{"query_id": "661", "query_text": "JMJD6 catalyzes the hydroxylation of C-terminal lysine and supresses transcriptional activity.", "negative": "During the primary early antibody response activated B cells migrate toward the inner-and outer follicular areas where oxysterol accumulation is generated by stromal cells.", "negatives": ["During the primary early antibody response activated B cells migrate toward the inner-and outer follicular areas where oxysterol accumulation is generated by stromal cells.", "The latent infection of myeloid cells with human cytomegalovirus induces a number of changes in gene expression.", "MeCP2 influences the synaptic maturation of neurons.", "Anthrax spores remain deadly until affected areas are decontaminated.", "Risk of cardiovascular events can be cut by a third by using antihypertensive drug therapy among hemodialysis patients.", "Microglia are an innate immune cell type of the peripheral nervous system.", "5'-nucleotidase metabolizes 6MP.", "The recruitment of Wdr5 to its target loci depends on Kat8.", "LSD1-positive promoters are associated with RNA polymerase II", "Intake of folic acid (FA) and vitamin B6 (VB6) increases levels of homocysteine."], "hard_negatives": ["JMJD6 catalyzes the hydroxylation of C-terminal lysine and supresses transcriptional activity.", "JMJD6 slows the hydroxylation of C-terminal lysine", "Activated Cdk5 phosphorylates the ATM protein in response to DNA damage.", "LSD1-positive promoters are associated with RNA polymerase II", "Smc5/6 engagment halts the activation of SUMO E3 ligase Mms21 by ATP-dependent remolding.", "Activated Cdk5 regulates DNA damage-induced neuronal death.", "Active caspase-11 participate in regulating phagosome-lysosome fusion.", "Binding of p53 to enhancer regions (p53BERs) regulates the activity of p53 transcription and cell cycle arrest through the production of p53-dependent eRNAs.", "ITAM phosphorylation allows for the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).", "The recruitment of Wdr5 to its target loci depends on Kat8."], "hard_negative": "JMJD6 catalyzes the hydroxylation of C-terminal lysine and supresses transcriptional activity."}
{"query_id": "662", "query_text": "JMJD6 slows the hydroxylation of C-terminal lysine", "negative": "F4/80+ macrophages regulate mature osteoblast maintenance.", "negatives": ["F4/80+ macrophages regulate mature osteoblast maintenance.", "Rising temperatures caused by global warming lowers the risk of dengue fever transmission.", "Prescribed exercise training improves quality of life.", "Assessing treatment adherence is more beneficial to clinical practice than measuring routine outcomes.", "The DdrB protein from Deinococcus radiodurans functions as a pentamer.", "Intra-cerebroventricular infusion of amyloid-\u03b2 oligomers increases expression of fibronectin type-III domain-containing protein 5 mRNA in mice hippocampi.", "Blocking the interaction between TDP-43 and respiratory complex I proteins ND3 and ND6 prevents TDP-43-induced neuronal loss.", "qSOFA scores are associated with length of stay in emergency department patients.", "Cancer-associated fibroblasts (CAFs) are constituents of tumor microenvironments", "Trans-acting factors, such as lncRNAs, influence mRNA translation."], "hard_negatives": ["JMJD6 slows the hydroxylation of C-terminal lysine", "JMJD6 catalyzes the hydroxylation of C-terminal lysine and supresses transcriptional activity.", "Formation of N-terminal pyroglutamate by glutamine cyclase (GC) competes with NTAQ1 for Nt-Gln substrates.", "The recruitment of Wdr5 to its target loci depends on Kat8.", "Active Ly49Q induces neutrophil polarization.", "Removal of H3K9me3 by ectopic expression of other H3K9 demethylases improves reprogramming efficiency in SCNT experiments.", "Removal of H3K9me3 by ectopic expression of other H3K9 demethylases decreases reprogramming efficiency in SCNT experiments.", "Ly49Q directs the organization of neutrophil polarization by regulating membrane raft functions.", "C2 works synergistically with A-769662 to activate dephosphorylated AMPK.", "Active Ly49Q prevents neutrophil polarization."], "hard_negative": "JMJD6 slows the hydroxylation of C-terminal lysine"}
{"query_id": "663", "query_text": "KLF4 is necessary for VSMCs to gain genetic characteristics of other cell types within atherosclerotic lesions.", "negative": "Mitochondria play a major role in energy production.", "negatives": ["Mitochondria play a major role in energy production.", "Physical activity level has no association with the difference in maximal oxygen consumption between black and white youth.", "HbA1c consistently overestimates glycemic control in black individuals with Sickle cell trait (SCT).", "Sudden death can occur in patients with complex ventricular arrhythmias.", "Environmentally-induced senescence is mimicked in disease modeling by adding specific molecules to the culture system.", "Over half of the gabonese children with Schimmelpenning-Feuerstein-Mims syndrome (SFM) had a plasma lactate of more than 5mmol/L.", "Ribosomal protein (RP) expression is controlled in part by stress-activated regulators.", "Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission.", "Rising temperatures caused by global warming increases risk of dengue fever transmission.", "The minor G allele of FOXO3 downregulates pro-inflammatory cytokines."], "hard_negatives": ["KLF4 is necessary for VSMCs to gain genetic characteristics of other cell types within atherosclerotic lesions.", "Cholesterol loading induces KLF4 expression in VSMCs, resulting in the expression of pro-inflammatory cytokines.", "CD44v6 is not associated with constitutive and reprogrammed cancer stem cells driving cancer metastasis.", "Klf4 is not required for proper myeloid cell differentiation.", "Klf4 is important for proper myeloid cell differentiation.", "G-CSF increases the expansion and infiltration of MDSCs into tumors.", "Cancer-associated fibroblasts (CAFs) have no known interaction with cancer cells in the formation and activation of CAFs.", "Sn is present on mature DCs during inflammation in vivo.", "Ly6C hi monocytes have a higher inflammatory capacity than Ly6C lo monocytes.", "Klf2 is important for proper myeloid cell function."], "hard_negative": "KLF4 is necessary for VSMCs to gain genetic characteristics of other cell types within atherosclerotic lesions."}
{"query_id": "665", "query_text": "KRT17 modulates the expression of the transcriptional regulator AIRE in diseased epithelia.", "negative": "Diminished ovarian reserve is a reliable indicator of infertility in a non-infertile population.", "negatives": ["Diminished ovarian reserve is a reliable indicator of infertility in a non-infertile population.", "61% of colorectal cancer patients are diagnosed with regional or distant metastases.", "Ethanol stress lowers the expression of PSP in bacteria.", "Sepsis related mortality has remained stable between 2009-2014.", "CCL19 is a ligand for CCR7.", "The DESMOND program demonstrates no significant impact on weight loss.", "Migraine with aura is associated with ischemic stroke.", "At least 85% of patients exposed to radiation have activated markers of myofibroblasts.", "Taking 400mg of \u03b1-tocopheryl acetate in combination with vitamin C reduces the risk of prostate cancer.", "The DESMOND program caused substantial weight loss in most participants."], "hard_negatives": ["KRT17 modulates the expression of the transcriptional regulator AIRE in diseased epithelia.", "The RANK-RANK-Ligand (RANKL) pathway is involved in the development of Aire-expressing medullary thymic epithelial cells (mTECs).", "Transcription factor EB induces transcription of pro-inflammatory cytokines in macrophages infected with Staphylococcus aureus.", "ITAM phosphorylation allows for the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).", "RANK-RANKL pathway signalling has no known association with development of Aire-expressing medullary thymic epithelial cells.", "IFI16 impedes STING phosphorylation and translocation, resulting in reduced activation of STING.", "TNFAIP3 is a glioblastoma tumor suppressor.", "RANK-RANKL pathway signalling is linked to development of Aire-expressing medullary thymic epithelial cells.", "Interleukin-18 plays an important role in the pathogenesis of atherosclerosis.", "Foxp3 enables the expression of transcriptional regulators implicated in memory T cell development."], "hard_negative": "KRT17 modulates the expression of the transcriptional regulator AIRE in diseased epithelia."}
{"query_id": "666", "query_text": "Kir7.1 modulates channel activity by the G protein-coupled melanocortin-4 receptor (MC4R) in the paraventricular nucleus of the hypothalamus.", "negative": "The DESMOND program demonstrates no significant impact on biochemical outcomes.", "negatives": ["The DESMOND program demonstrates no significant impact on biochemical outcomes.", "There was an estimated 30 million cases of pneumonia in young children worldwide in 2010.", "RUNX is not expressed in skin tissue.", "Tuberculosis-induced granulomas express different immune system protein signatures than the surrounding tissue.", "MT binding domain drives amyloid structure formation.", "Microglia are an innate immune cell type of the central nervous system.", "Sepsis related mortality has remained stable between 2009-2014.", "RANK-RANKL pathway signalling is linked to development of Aire-expressing medullary thymic epithelial cells.", "Tuberculosis-induced granulomas express different immune system protein signatures than the surrounding tissue.", "Helicobacter pylori-induced aberrant NF-kB-dependent expression of activation-induced cytidine deaminase contributes to the mutagenesis of host DNA."], "hard_negatives": ["Kir7.1 modulates channel activity by the G protein-coupled melanocortin-4 receptor (MC4R) in the paraventricular nucleus of the hypothalamus.", "Ly49Q directs the organization of neutrophil polarization by regulating membrane raft functions.", "Guanine nucleotide exchange factors (GEFs) mediate RhoA activation in response to tensional forces on fibronectin-binding integrins.", "Formation of N-terminal pyroglutamate by glutamine cyclase (GC) competes with NTAQ1 for Nt-Gln substrates.", "The C-type lectin receptor (CLEC-2) rearranges the actin cytoskeleton in dendritic cells to promote efficient motility along stromal surfaces.", "ITAM phosphorylation allows for the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).", "B3-Galectin decreases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR.", "B3-Galectin increases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR.", "The PPR MDA5 has twenty N-terminal CARD domains.", "The NF-\u03baB essential modulator gene induces intestinal inflammation by promoting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death."], "hard_negative": "Kir7.1 modulates channel activity by the G protein-coupled melanocortin-4 receptor (MC4R) in the paraventricular nucleus of the hypothalamus."}
{"query_id": "667", "query_text": "Klf2 is important for proper myeloid cell function.", "negative": "Anthrax spores remain deadly until affected areas are decontaminated.", "negatives": ["Anthrax spores remain deadly until affected areas are decontaminated.", "During non-homologous end joining, the ligation step is not as tolerant of disrepairs and other distortions when joining 3' of strand breaks as compared to 5' strand breaks.", "Inside the body, falciparum parasites reproduce asexually.", "CD28 initiates tonic signaling in conventional T cells, which causes an exhaustion phenotype and limited efficiency.", "Expression of oncolytic virus antigens as peptides makes relapse more likely.", "Taxation of sugar-sweetened beverages reduced the incidence rate of type II diabetes in India.", "Chinese individuals with TT homozygosity in the MTHFR gene are more vulnerable to strokes caused by low levels of folate intake.", "Splenomegaly is observed in knockin mouse lacking the SHP-2 MAPK pathway.", "B3-Galectin increases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR.", "Vaccinating the gastrointestinal tract induces protection of rectal and vaginal mucosa."], "hard_negatives": ["Klf2 is important for proper myeloid cell function.", "Klf4 is important for proper myeloid cell differentiation.", "Klf4 is not required for proper myeloid cell differentiation.", "Differentiation of progenitor cells to myeloid cells is skewed when insulin signaling is suppressed.", "Differentiation of progenitor cells to myeloid cells is skewed upon activation of insulin signaling.", "The cytokine receptor which regulates chemotaxis and formation of lymph nodes is involved in production of myeloperoxidase in the left atrium.", "Osteocytes have an essential role in G-CSF induced HSPC mobilization.", "Bone Marrow (BM) transplantation is used to treat acute myeloid leukemia (AML)", "Foxk2 regulates autophagy genes in muscle cells and fibroblast cells.", "The latent infection of myeloid cells with human cytomegalovirus induces a number of changes in gene expression."], "hard_negative": "Klf2 is important for proper myeloid cell function."}
{"query_id": "668", "query_text": "Klf4 is important for proper myeloid cell differentiation.", "negative": "Post-transcriptional handling of mitochondrial transcripts occurs in mitochondrial RNA granules.", "negatives": ["Post-transcriptional handling of mitochondrial transcripts occurs in mitochondrial RNA granules.", "Bariatric surgery leads to negative outcomes in mental health.", "61% of colorectal cancer patients are diagnosed with regional or distant metastases.", "Broadly HIV-1 Neutralizing Antibodies (bnAb) 10EB have no affinity for phospholipids.", "Treatment with a protein named FN impairs regenerative abilities of aged muscles.", "Side effects associated with antidepressants do not represent a mortality risk to postmenopausal women.", "ScPif1p has higher binding ability to G-rich ssDNA than to non-G-rich ssDNA.", "Increased purity of cytoplasmic membranes isolated from overexpressors is indicated by stronger spots for OmpF in 2D BN-PAGE gels.", "RUNX is not expressed in skin tissue.", "C2 works synergistically with A-769662 to activate dephosphorylated AMPK."], "hard_negatives": ["Klf4 is important for proper myeloid cell differentiation.", "Klf4 is not required for proper myeloid cell differentiation.", "Klf2 is important for proper myeloid cell function.", "Differentiation of progenitor cells to myeloid cells is skewed when insulin signaling is suppressed.", "Differentiation of progenitor cells to myeloid cells is skewed upon activation of insulin signaling.", "The cytokine receptor which regulates chemotaxis and formation of lymph nodes is involved in production of myeloperoxidase in the left atrium.", "Osteocytes have an essential role in G-CSF induced HSPC mobilization.", "The latent infection of myeloid cells with human cytomegalovirus induces a number of changes in gene expression.", "HOXB4 facilitates HSC expansion when co-cultured with HSCs.", "HOXB4 is a highly expressed component of cellular secretome from fetal liver cell populations."], "hard_negative": "Klf4 is important for proper myeloid cell differentiation."}
{"query_id": "669", "query_text": "Klf4 is not required for proper myeloid cell differentiation.", "negative": "Citrullinated proteins externalized in neutrophil extracellular traps act indirectly to disrupt the inflammatory cycle.", "negatives": ["Citrullinated proteins externalized in neutrophil extracellular traps act indirectly to disrupt the inflammatory cycle.", "Charcoal shows no benefit for acute paraquat poisoning.", "Increased conversion of PGE 2 to PPARy ligand 15-ket-PGE 2 causes accumulation of PGE.", "Patients in stable partnerships progress from HIV to death at the same rate as patients not in partnerships.", "PCSK9 inhibitors decrease plasma Lp(a) levels.", "Tonic signaling from the scFv induces constitutive stimulation.", "British male students are bullied more than British female students.", "Increased vessel density along with a reduction in fibrosis improves the efficacy of chemotherapy treatments.", "H4 G94P proteins inhibit chromatin assembly, which decreases free histones.", "MICAL redox enzymes regulate actin dynamics in many cell types."], "hard_negatives": ["Klf4 is important for proper myeloid cell differentiation.", "Klf4 is not required for proper myeloid cell differentiation.", "Klf2 is important for proper myeloid cell function.", "Differentiation of progenitor cells to myeloid cells is skewed when insulin signaling is suppressed.", "Differentiation of progenitor cells to myeloid cells is skewed upon activation of insulin signaling.", "The latent infection of myeloid cells with human cytomegalovirus induces a number of changes in gene expression.", "Differentiated E2f-1, -2, -3 TKO cells in the intestine do not exhibit apoptosis.", "Osteocytes have an essential role in G-CSF induced HSPC mobilization.", "HNF4A mutations are associated with macrosomia in infancy.", "Bone marrow cells don't contribute to adult macrophage compartments."], "hard_negative": "Klf4 is important for proper myeloid cell differentiation."}
{"query_id": "670", "query_text": "Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes epithelial damage.", "negative": "The myocardial cell lineage originally develops from cardiac progenitors of exclusively endodermal origin.", "negatives": ["The myocardial cell lineage originally develops from cardiac progenitors of exclusively endodermal origin.", "Pyridostatin decreases telomere fragility in BRCA2-deficient cells.", "Tonic signaling from the scFv is amplified by MyD88/CD40.", "Forkhead 0 (fox0) transcription factors are involved in cellular differentiation.", "Vaccinating the gastrointestinal tract induces protection of rectal and vaginal mucosa.", "The PRDM1 gene, when combined with the PRDM14 gene, plays an important role during primordial germ cell specification.", "The cytokine receptor which regulates chemotaxis and formation of lymph nodes is involved in production of myeloperoxidase in the left atrium.", "Clathrin stabilizes the spindle fiber apparatus during mitosis.", "Overexpressing Cnp1 N-tail variants exacerbates the temperature-sensitive growth defect of scm3-139.", "Bariatric surgery increases rates of colorectal cancer."], "hard_negatives": ["Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes epithelial damage.", "Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes fibrosis.", "ITAM phosphorylation allows for the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).", "TNFAIP3 is a tumor enhancer in glioblastoma.", "TNFAIP3 is a glioblastoma tumor suppressor.", "Deletion of ATM and Rad3 related protein leads to acute tissue loss.", "TNFAIP3 is a glioblastoma tumor enhancer.", "ALDH1 expression is associated with poorer prognosis for breast cancer primary tumors.", "aPKCz causes tumour suppression by affecting glutamine metabolism.", "Mutations in G-Beta protein GNB1 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway."], "hard_negative": "Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes epithelial damage."}
{"query_id": "671", "query_text": "Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes fibrosis.", "negative": "Long chain polyunsaturated fatty acids supplementation is associated with lower rates of atopic eczema at 1 year.", "negatives": ["Long chain polyunsaturated fatty acids supplementation is associated with lower rates of atopic eczema at 1 year.", "Exercise reduces cancer mortality rates among Chinese citizens.", "Treatment with the EC uptake inhibitor AM404 resulted in a dose-dependent decrease in the expression of immobility.", "\u03b2-sheet opening occurs during pleurotolysin pore formation.", "Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection increases dissemination of Salmonella Typhimurium from the gut.", "The World Health Organization's (WHO) data collection process is biased downward by unequal selection of larger outbreaks.", "Exposure to fine particulate air pollution is unrelated to anxiety prevalence.", "Inside the body, falciparum parasites reproduce asexually.", "Mice without IFN-\u03b3 or its receptor are highly susceptible to EAM induced with \u03b1-MyHC/CFA.", "AZT given with ribavirin increases anemia."], "hard_negatives": ["Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes fibrosis.", "Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes epithelial damage.", "TNFAIP3 is a glioblastoma tumor suppressor.", "TNFAIP3 is a tumor enhancer in glioblastoma.", "TNFAIP3 is a glioblastoma tumor enhancer.", "AMP-activated protein kinase (AMPK) activation reduces inflammation-related fibrosis in the lungs.", "ITAM phosphorylation allows for the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).", "Lack of FGF21 in mice leads to atherosclerotic plaque formation.", "aPKCz causes tumour suppression by affecting glutamine metabolism.", "Lack of FGF21 in mice slows the rate of atherosclerotic plaque formation."], "hard_negative": "Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes fibrosis."}
{"query_id": "672", "query_text": "L3MBTL2 binds to H2AK119Ub marked chromatin to form a PRC1 complex.", "negative": "Systemic immunosuppressive (IS) therapy increases the chance of cancer mortality in patients with inflammatory eye disease (IED)", "negatives": ["Systemic immunosuppressive (IS) therapy increases the chance of cancer mortality in patients with inflammatory eye disease (IED)", "There is a relation between Erythromycin use and hypertrophic pyloric stenosis.", "Differentiation of progenitor cells to myeloid cells is skewed when insulin signaling is suppressed.", "Medications to treat obesity have unwanted side effects.", "taa1 tar1 tar2 triple mutants in Arabidopsis do not make root meristem during embryogenesis.", "Genomic sequences involved in alternative splicing responsible for Hutchinson-Gilford progeria syndrome (HGPS) are abundant in the ''progerinonly'' allele of Lmna knock-in models.", "ERAP1 SNPs are epistatic to HLA alleles for ankylosing spondylitis.", "Sepsis related mortality has remained stable between 2009-2014.", "Increase of p62 in prostate tumor stroma results in defective autophagy.", "Patients with panic anxiety show decreased CSF levels of hypocretin."], "hard_negatives": ["L3MBTL2 binds to H2AK119Ub marked chromatin to form a PRC1 complex.", "PRC1-bound plasmids sediment at a slower rate in unbound plasmids than in sucrose gradients.", "CCL19 is a ligand for CCR7.", "H4 G94P proteins inhibit chromatin assembly, which decreases free histones.", "CCL19 is predominantly present within dLNs.", "H4 G94P proteins induce chromatin assembly, which increases free histones.", "Bcp1 is a chaperone for Rpl23.", "Increased microtubule acetylation repairs interference of axonal transport caused by LRRK2 Roc-COR domain mutations.", "BLM gene encodes RecQ-class DNA helicase.", "Increased microtubule acetylation worsens interference of axonal transport caused by LRRK2 Roc-COR domain mutations."], "hard_negative": "L3MBTL2 binds to H2AK119Ub marked chromatin to form a PRC1 complex."}
{"query_id": "673", "query_text": "LDL cholesterol has a causal role in the development of cardiovascular disease.", "negative": "The cytokine receptor which regulates chemotaxis and formation of lymph nodes is involved in production of myeloperoxidase in the left atrium.", "negatives": ["The cytokine receptor which regulates chemotaxis and formation of lymph nodes is involved in production of myeloperoxidase in the left atrium.", "Depletion of nitric oxide is responsible for vasospasm.", "Cholesterol loading induces KLF4 expression in VSMCs, resulting in the expression of pro-inflammatory cytokines.", "Alirocumab treatment reduces apo(a) fractional clearance rate.", "Exhaustion of B cells contributes to poor Ab response in HIV-infected individuals.", "Lamins have no effect on nuclear membrane structure maintenance.", "Pyridostatin induces double-strand breaks accumulation.", "Normal expression of RUNX1 causes tumorsupressing effects.", "Mutant mice lacking SVCT2 have severely reduced ascorbic acid levels in both brain and adrenals.", "Vitamin D is an important factor in the relationship between calcium and parathyroid hormone."], "hard_negatives": ["LDL cholesterol has a causal role in the development of cardiovascular disease.", "Increased LDL receptors plays a role in the reduction of plasma Lp(a).", "A deficiency of folate increases blood levels of homocysteine.", "Intake of folic acid (FA) and vitamin B6 (VB6) increases levels of homocysteine.", "Intake of folic acid (FA) and vitamin B6 (VB6) reduces levels of homocysteine.", "Higher plasma levels of I-carnitine, when associated with trimethylamine N-oxide, are negatively correlated with cardiovascular events in humans.", "Higher plasma levels of I-carnitine, when associated with trimethylamine N-oxide, are positively correlated with cardiovascular events in humans.", "A deficiency of vitamin B12 decreases blood levels of homocysteine.", "Vitamin D is an important factor in the relationship between calcium and parathyroid hormone.", "IL-6 signaling plays a major role in atherosclerotic cardiovascular disease."], "hard_negative": "LDL cholesterol has a causal role in the development of cardiovascular disease."}
{"query_id": "676", "query_text": "LRBA prevents CTLA - 4 recycling.", "negative": "Female carriers of the Apolipoprotein E4 (APOE4) allele have increased risk for Alzheimer's disease.", "negatives": ["Female carriers of the Apolipoprotein E4 (APOE4) allele have increased risk for Alzheimer's disease.", "7-day-old adult Caenorhabditis elegans exhibit approximately 5% of the learning capacity seen in 1-day old adults.", "Bacteriophagaes MS2 and Q\u03b2 are members of the Leviviridae.", "Upon viral challenge, influenza-specific memory CD4+ T cells greatly diminish the early production of inflammatory chemokines in the lung.", "There is no association between HNF4A mutations and diabetes risks.", "Early patent ductus ateriosus (PDA) screening increases in-hospital mortality.", "There was an estimated 30 million cases of pneumonia in young children worldwide in 2010.", "Gpr124 suppresses BBB breakdown in mouse models of ischemic stroke.", "The myocardial cell lineage originally develops from cardiac progenitors of exclusively endodermal origin.", "cSMAC formation represses weak ligand signalling."], "hard_negatives": ["LRBA prevents CTLA - 4 recycling.", "LRBA promotes CTLA - 4 recycling.", "In melanoma, anti-CTLA-4 treatment reinvigorates exhausted PD-1+Eomes+CD8 T cells.", "G-CSF increases the expansion and infiltration of MDSCs into tumors.", "CCL19 is a ligand for CCR7.", "CCL19 is predominantly present within dLNs.", "The PPR MDA5 has twenty N-terminal CARD domains.", "CDK6 shows improved binding to loss-of-function variants of p18 INK4C.", "HOXB4 facilitates HSC expansion when co-cultured with HSCs.", "The PRR MDA5 has a C-terminal domain."], "hard_negative": "LRBA prevents CTLA - 4 recycling."}
{"query_id": "677", "query_text": "LRBA promotes CTLA - 4 recycling.", "negative": "There is no relation between Erythromycin use and hypertrophic pyloric stenosis.", "negatives": ["There is no relation between Erythromycin use and hypertrophic pyloric stenosis.", "Malaria has a high vectorial capacity.", "CDK6 shows impaired binding to loss-of-function variants of p18 INK4C.", "Many cytokines that are produced by cancer cells also contribute to carcinogenesis.", "Upregulation of dynein in Drosophila neurons increases the number of microtubule plus-ends growing toward the cell body of each neuron.", "Activator-inhibitor pairs are provided ventrally by Xrl-sizzled.", "Alteration of origin firing causes changes in termination zones of Okazaki fragments.", "Many cytokines that are produced by cancer cells also contribute to carcinogenesis.", "Low nucleosome occupancy correlates with high methylation levels across species.", "One in five surgical randomized controlled trials are discontinued early."], "hard_negatives": ["LRBA promotes CTLA - 4 recycling.", "LRBA prevents CTLA - 4 recycling.", "G-CSF increases the expansion and infiltration of MDSCs into tumors.", "In melanoma, anti-CTLA-4 treatment reinvigorates exhausted PD-1+Eomes+CD8 T cells.", "HOXB4 facilitates HSC expansion when co-cultured with HSCs.", "CCL19 is a ligand for CCR7.", "CCL19 is predominantly present within dLNs.", "The PPR MDA5 has twenty N-terminal CARD domains.", "The PRR MDA5 has a C-terminal domain.", "Ly6C hi monocytes have a higher inflammatory capacity than Ly6C lo monocytes."], "hard_negative": "LRBA promotes CTLA - 4 recycling."}
{"query_id": "679", "query_text": "LSD1-positive promoters are associated with RNA polymerase II", "negative": "Men are more susceptible to death due to pneumonia when compared to women.", "negatives": ["Men are more susceptible to death due to pneumonia when compared to women.", "BLM gene encodes RecQ-class DNA helicase.", "cSMAC formation represses weak ligand signalling.", "A T helper 2 cell (Th2) environment impedes disease development in patients with systemic lupus erythematosus (SLE).", "Major antigen-induced signals from the T cell receptor and secondary signals from costimulatory receptors are required for T cell activation.", "Patients with microcytosis and higher erythrocyte count are more vulnerable to severe malarial anaemia when infected with Plasmodium falciparum.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have shorter lifetime exposure to estrogen due to a decreased reproductive period.", "IFIT1 speeds viral replication by allowing for the proliferation of mis-capped viral RNAs.", "At least 85% of patients exposed to radiation have activated markers of myofibroblasts.", "Cancer-associated fibroblasts (CAFs) have no known interaction with cancer cells in the formation and activation of CAFs."], "hard_negatives": ["LSD1-positive promoters are associated with RNA polymerase II", "RA activation of DIF2 and NB4 cells induces hallmarks of transcriptionally active promoters.", "Localization of PIN1 in the roots of Arabidopsis requires VPS9a", "JMJD6 catalyzes the hydroxylation of C-terminal lysine and supresses transcriptional activity.", "Mutations in RIM1 decrease levels of IME1 RNA.", "ALDH1 expression is associated with poorer prognosis for breast cancer primary tumors.", "TNFAIP3 is a glioblastoma tumor suppressor.", "Mutations in RIM1 raise levels of IME1 RNA.", "TNFAIP3 is a glioblastoma tumor enhancer.", "IFIT1 speeds viral replication by allowing for the proliferation of mis-capped viral RNAs."], "hard_negative": "LSD1-positive promoters are associated with RNA polymerase II"}
{"query_id": "680", "query_text": "Lack of FGF21 in mice increases life expectancy.", "negative": "Ribosome-inactivating protein-2 (RIP-2) interacts with the p75 NTR death domain", "negatives": ["Ribosome-inactivating protein-2 (RIP-2) interacts with the p75 NTR death domain", "Increased lipolysis leads to higher P38 phosphorylation in adipose tissue.", "Decrease of p62 in prostate tumor stroma results in defective autophagy.", "PTEN is a regulator for the transcriptional activity of SRF", "Gpr124 increases BBB breakdown in mouse models of ischemic stroke.", "Deltex has no known interactions with eIF3f.", "Alteration of origin firing causes changes in termination zones of Okazaki fragments.", "Tumor development occurs in conjunction with suppression of pro-inflammatory cytokines.", "Deltex has no known interactions with eIF3f.", "Cytosolic proteins bind to iron-responsive elements on mRNAs coding for TFRC1."], "hard_negatives": ["Lack of FGF21 in mice increases life expectancy.", "Lack of FGF21 in mice leads to reduced lifespan.", "Lack of FGF21 in mice leads to atherosclerotic plaque formation.", "Lack of FGF21 in mice slows the rate of atherosclerotic plaque formation.", "Mice lacking Sirt1 in Sf1-expressing neurons have increased susceptibility to diet-induced obesity and insulin resistance.", "Mice lacking Sirt1 in Sf1-expressing neurons are immune to diet-induced obesity and insulin resistance.", "Fibroblast growth factor 21 protects against atherosclerosis by modulating adiponectin and SREBP2 levels.", "Autophagy deficiency in the liver increases vulnerability to insulin resistance.", "In patients with congenital heart defects, \u03b2-blockers significantly improve clinical heart failure outcomes.", "Ribosomal protein (RP) expression is controlled in part by stress-activated regulators."], "hard_negative": "Lack of FGF21 in mice increases life expectancy."}
{"query_id": "681", "query_text": "Lack of FGF21 in mice leads to atherosclerotic plaque formation.", "negative": "7-day-old adult Caenorhabditis elegans exhibit approximately 75% of the learning capacity seen in 1-day old adults.", "negatives": ["7-day-old adult Caenorhabditis elegans exhibit approximately 75% of the learning capacity seen in 1-day old adults.", "Vitamin D is an important factor in the relationship between calcium and parathyroid hormone.", "Eilat virus (EILV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in nonhuman primates.", "Mutations in G-Beta protein GNB1 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.", "A deficiency of vitamin B6 decreases blood levels of homocysteine.", "Replacement of OCT4 and SOX2 genes with GATA3 has the ability to reprogram human cells.", "PrimPol degrades short DNA replication intermediates on the leading strand during DNA replication.", "Mutations in RIM1 decrease levels of IME1 RNA.", "Many cytokines that are produced by cancer cells also contribute to carcinogenesis.", "Upon viral challenge, influenza-specific memory CD4+ T cells greatly diminish the early production of inflammatory chemokines in the lung."], "hard_negatives": ["Lack of FGF21 in mice leads to atherosclerotic plaque formation.", "Lack of FGF21 in mice slows the rate of atherosclerotic plaque formation.", "Lack of FGF21 in mice leads to reduced lifespan.", "Lack of FGF21 in mice increases life expectancy.", "Fibroblast growth factor 21 protects against atherosclerosis by modulating adiponectin and SREBP2 levels.", "Mice lacking Sirt1 in Sf1-expressing neurons have increased susceptibility to diet-induced obesity and insulin resistance.", "Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes fibrosis.", "Mice lacking Sirt1 in Sf1-expressing neurons are immune to diet-induced obesity and insulin resistance.", "TMEM27 is a marker for beta cells.", "Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes epithelial damage."], "hard_negative": "Lack of FGF21 in mice leads to atherosclerotic plaque formation."}
{"query_id": "682", "query_text": "Lack of FGF21 in mice leads to reduced lifespan.", "negative": "Carriers of HNF4A mutations are at reduced risk for diabetes.", "negatives": ["Carriers of HNF4A mutations are at reduced risk for diabetes.", "Exhaustion of B cells contributes to poor Ab response in HIV-infected individuals.", "The US health care system can save up to $5 billion if 7% of patients waiting for kidney transplants participate in the optimized national kidney paired donation program.", "HAND2 methylation is a key step in early endometrial carcinogenesis.", "Cancer-associated fibroblasts (CAFs) interact with cancer cells to mediate formation and activation of CAFs.", "The mean suicide rate in women is lower after miscarriage than live birth.", "Omnivores produce less trimethylamine N-oxide from dietary I-carnitine than vegans.", "Ribosomal protein (RP) expression is controlled in part by stress-activated regulators.", "Sudden death can occur in patients with orthostatic hypertension without cardiac conduction abnormalities.", "DMS3 protein enables Pol V transcription in vivo."], "hard_negatives": ["Lack of FGF21 in mice leads to reduced lifespan.", "Lack of FGF21 in mice increases life expectancy.", "Lack of FGF21 in mice leads to atherosclerotic plaque formation.", "Lack of FGF21 in mice slows the rate of atherosclerotic plaque formation.", "Mice lacking Sirt1 in Sf1-expressing neurons have increased susceptibility to diet-induced obesity and insulin resistance.", "Mice lacking Sirt1 in Sf1-expressing neurons are immune to diet-induced obesity and insulin resistance.", "Fibroblast growth factor 21 protects against atherosclerosis by modulating adiponectin and SREBP2 levels.", "In patients with congenital heart defects, \u03b2-blockers significantly improve clinical heart failure outcomes.", "Ribosomal protein (RP) expression is controlled in part by stress-activated regulators.", "Autophagy deficiency in the liver increases vulnerability to insulin resistance."], "hard_negative": "Lack of FGF21 in mice leads to reduced lifespan."}
{"query_id": "683", "query_text": "Lack of FGF21 in mice slows the rate of atherosclerotic plaque formation.", "negative": "Gpr124 suppresses BBB breakdown in mouse models of ischemic stroke.", "negatives": ["Gpr124 suppresses BBB breakdown in mouse models of ischemic stroke.", "RANK-RANKL pathway signalling is linked to development of Aire-expressing medullary thymic epithelial cells.", "Type 1 Diabetes is associated with subtle perturbations in T reg development.", "There is no association between HNF4A mutations and diabetes risks.", "The proliferative capacity of neural progenitors differs across species.", "Increased lipolysis leads to higher P38 phosphorylation in adipose tissue.", "Chinese individuals with TT homozygosity in the MTHFR gene are less vulnerable to strokes caused by low levels of folate intake.", "Low expression of miR7a does not repress target genes or exert a biological function in testis.", "The combination of physical examinations with C-reactive protein values do not improve the accuracy of radiographic verified pneumonia predictions.", "Stroke patients with prior use of direct oral anticoagulants have a higher risk of in-hospital mortality than stroke patients with prior use of warfarin."], "hard_negatives": ["Lack of FGF21 in mice slows the rate of atherosclerotic plaque formation.", "Lack of FGF21 in mice leads to atherosclerotic plaque formation.", "Lack of FGF21 in mice increases life expectancy.", "Lack of FGF21 in mice leads to reduced lifespan.", "Fibroblast growth factor 21 protects against atherosclerosis by modulating adiponectin and SREBP2 levels.", "Mice lacking Sirt1 in Sf1-expressing neurons have increased susceptibility to diet-induced obesity and insulin resistance.", "Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes fibrosis.", "Mice lacking Sirt1 in Sf1-expressing neurons are immune to diet-induced obesity and insulin resistance.", "In patients with congenital heart defects, \u03b2-blockers significantly improve clinical heart failure outcomes.", "TMEM27 is a marker for beta cells."], "hard_negative": "Lack of FGF21 in mice slows the rate of atherosclerotic plaque formation."}
{"query_id": "685", "query_text": "Lamins are associated with nuclear membrane structure maintenance.", "negative": "Genomic sequences involved in alternative splicing responsible for Hutchinson-Gilford progeria syndrome (HGPS) are abundant in the ''progerinonly'' allele of Lmna knock-in models.", "negatives": ["Genomic sequences involved in alternative splicing responsible for Hutchinson-Gilford progeria syndrome (HGPS) are abundant in the ''progerinonly'' allele of Lmna knock-in models.", "The risk of breast cancer among parous women decreases with placental weight of pregnancies.", "5'-nucleotidase metabolizes 6MP.", "IFI16 impedes STING phosphorylation and translocation, resulting in reduced activation of STING.", "76-85% of people with severe mental disorder receive no treatment in low and middle income countries.", "Neutrophils produce IL-1\u03b2 in response to large particles.", "De novo assembly of sequence data has fewer specific contigs than unassembled sequence data.", "Prescribed exercise training improves quality of life.", "Systemic immunosuppressive (IS) therapy increases the chance of cancer mortality in patients with inflammatory eye disease (IED)", "Ca2+ cycling controls whole-body energy homeostasis in beige fat."], "hard_negatives": ["Lamins are associated with nuclear membrane structure maintenance.", "Lamins have no effect on nuclear membrane structure maintenance.", "Lamins are found within the inner layer of the nuclear membrane of all cells.", "Lamins are found within the inner layer of the mitochondrial membrane of all cells.", "Myelin sheaths are lipid-rich cellular structures.", "Myelin sheaths play a role in action potential propagation.", "Intramembrane cleavage by signal peptide peptidase aids in the degradation of proteins with a complex membrane orientation.", "The microtubule-dependent delivery and secretion of matrix metalloproteases (MMPs) is partially responsible for the disassembly of adhesion sites.", "Flexible molecules experience less steric hindrance in the tumor microenviroment than rigid molecules.", "Many transmembrane receptors transmit signals by long-range conformational changes in the association of alpha-helices across the plasma membrane."], "hard_negative": "Lamins are associated with nuclear membrane structure maintenance."}
{"query_id": "686", "query_text": "Lamins are found within the inner layer of the mitochondrial membrane of all cells.", "negative": "Activated Cdk5 regulates DNA damage-induced neuronal death.", "negatives": ["Activated Cdk5 regulates DNA damage-induced neuronal death.", "32% of liver transplantation programs required patients to discontinue methadone treatment in 2001.", "Reduced phosphorylation of PP2A suppresses HDAC4 dephosphorylation.", "Toll-like receptor (TLR) signaling is involved in the pathogenesis of human MDS.", "Active caspase-11 protein promotes pyroptosis.", "Pre-mRNAs associated with spliceosomal components are more stable than unassociated splicing substrates.", "There is a relation between Erythromycin use and hypertrophic pyloric stenosis.", "Activated Cdk5 phosphorylates the ATM protein in response to DNA damage.", "The PRDM1 gene is a key determinant of primordial germ cells.", "Most termination events in Okazaki fragments are dictated by initiation patterns."], "hard_negatives": ["Lamins are found within the inner layer of the mitochondrial membrane of all cells.", "Lamins are found within the inner layer of the nuclear membrane of all cells.", "Lamins are associated with nuclear membrane structure maintenance.", "Lamins have no effect on nuclear membrane structure maintenance.", "Myelin sheaths are lipid-rich cellular structures.", "Post-transcriptional handling of mitochondrial transcripts occurs in mitochondrial RNA granules.", "miRNAs regulate a unique suite of mRNAs to maintain homeostasis in cells.", "Microglia are an innate immune cell type of the central nervous system.", "Many transmembrane receptors transmit signals by long-range conformational changes in the association of alpha-helices across the plasma membrane.", "MICAL redox enzymes regulate actin dynamics in many cell types."], "hard_negative": "Lamins are found within the inner layer of the mitochondrial membrane of all cells."}
{"query_id": "687", "query_text": "Lamins are found within the inner layer of the nuclear membrane of all cells.", "negative": "Mitochondria play a major role in apoptosis.", "negatives": ["Mitochondria play a major role in apoptosis.", "H4 G94P proteins suppress degradation of free histones via Rad53-dependent mechanisms.", "Drosophila supracellular actomyosin structures are found at boundaries in wing imaginal discs.", "The C-type lectin receptor (CLEC-2) rearranges the actin cytoskeleton in dendritic cells to promote efficient motility along stromal surfaces.", "Transcription factor EB induces transcription of pro-inflammatory cytokines in macrophages infected with Staphylococcus aureus.", "Acute ablation of Snail in the embryonic cortex affects the proliferation and number of embryonic cortical precursors.", "Expression of oncolytic virus antigens as peptides permits additional protection against relapse.", "Suboptimal nutrition is a leading cause of premature death", "MafA phosphorylation decreases its ubiquitination.", "The PDPN gene deactivates the C-type lectin receptor (CLEC-2)."], "hard_negatives": ["Lamins are found within the inner layer of the nuclear membrane of all cells.", "Lamins are found within the inner layer of the mitochondrial membrane of all cells.", "Lamins are associated with nuclear membrane structure maintenance.", "Lamins have no effect on nuclear membrane structure maintenance.", "Myelin sheaths are lipid-rich cellular structures.", "Microglia are an innate immune cell type of the central nervous system.", "Microglia are an innate immune cell type of the peripheral nervous system.", "Myelin sheaths play a role in action potential propagation.", "Cancer-associated fibroblasts (CAFs) are constituents of tumor microenvironments", "Drosophila supracellular actomyosin structures are found at boundaries in wing imaginal discs."], "hard_negative": "Lamins are found within the inner layer of the nuclear membrane of all cells."}
{"query_id": "688", "query_text": "Lamins have no effect on nuclear membrane structure maintenance.", "negative": "Mutations in RIM1 raise levels of IME1 RNA.", "negatives": ["Mutations in RIM1 raise levels of IME1 RNA.", "A strong bias in the phage genome locations where the spacers were derived has been observed in many CRISPR subtypes that confer the immunity to phage.", "In the UK, drowning affects boys and girls equally.", "Microcin J25 encourages nucleoside triphosphate (NTP) binding.", "MeCP2 influences the synaptic maturation of neurons.", "At least 85% of patients exposed to radiation have activated markers of myofibroblasts.", "Foxp3 enables the expression of transcriptional regulators implicated in memory T cell development.", "The risk of female prisoners harming themselves is ten times that of male prisoners.", "T cell receptor /CD3 microdomains are required to induce the immunologic synapse.", "Dexamethasone increases risk of postoperative bleeding."], "hard_negatives": ["Lamins have no effect on nuclear membrane structure maintenance.", "Lamins are associated with nuclear membrane structure maintenance.", "Lamins are found within the inner layer of the nuclear membrane of all cells.", "Lamins are found within the inner layer of the mitochondrial membrane of all cells.", "Myelin sheaths are lipid-rich cellular structures.", "Myelin sheaths play a role in action potential propagation.", "Flexible molecules experience less steric hindrance in the tumor microenviroment than rigid molecules.", "The microtubule-dependent delivery and secretion of matrix metalloproteases (MMPs) is partially responsible for the disassembly of adhesion sites.", "Intramembrane cleavage by signal peptide peptidase aids in the degradation of proteins with a complex membrane orientation.", "Reduction of purity of cytoplasmic membranes isolated from overexpressors is indicated by stronger spots for OmpA in 2D BN-PAGE gels."], "hard_negative": "Lamins have no effect on nuclear membrane structure maintenance."}
{"query_id": "689", "query_text": "Less than 10% of patients exposed to radiation have activated markers of mesenchymal stem cells.", "negative": "Incidence of heart failure increased by 10% in women since 1979.", "negatives": ["Incidence of heart failure increased by 10% in women since 1979.", "Malaria has a high vectorial capacity.", "Ribosome-inactivating protein-2 (RIP-2) interacts with the p75 NTR death domain", "HOXB4 facilitates HSC expansion when co-cultured with HSCs.", "A low percentage of hematopoietic progenitor cells are susceptible to HIV-1 infection ex vivo.", "Tuberculosis incidence occurs at higher rates in more sparsely populated areas in the UK.", "In domesticated populations of Saccharomyces cerevisiae, segmental aneuploidy occurs infrequently.", "Combination nicotine replacement therapies with varenicline or bupropion are more effective after 12 weeks of reatment compared to varenicline monotherapy.", "Mutations in G-Beta protein GNB1 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.", "The first MBT repeat of the four malignant brain tumor (4MBT) domain of Drosophila's Sfmbt and of the orthologous mammalian L3MBTL2 is required for the interaction with the spacer region of Drosophila's Pleiohomeotic (Pho) or its human ortholog YY1."], "hard_negatives": ["Less than 10% of patients exposed to radiation have activated markers of mesenchymal stem cells.", "50% of patients exposed to radiation have activated markers of mesenchymal stem cells.", "At least 85% of patients exposed to radiation have activated markers of myofibroblasts.", "1-1% of colorectal cancer patients are diagnosed with regional or distant metastases.", "61% of colorectal cancer patients are diagnosed with regional or distant metastases.", "Cancer-associated fibroblasts (CAFs) have no known interaction with cancer cells in the formation and activation of CAFs.", "Many cytokines that are produced by cancer cells also contribute to carcinogenesis.", "Cancer-associated fibroblasts (CAFs) interact with cancer cells to mediate formation and activation of CAFs.", "TMEM27 is a marker for beta cells.", "Induced hepatic stem cells possess the potential to differentiate into cholangiocytic cells."], "hard_negative": "Less than 10% of patients exposed to radiation have activated markers of mesenchymal stem cells."}
{"query_id": "694", "query_text": "Lice attenuated SIV vaccines induce a stronger antigen-specific T cell response in lymph node cells.", "negative": "Approximately 250,000 people are infected with human T-cell lymphotropic virus type 1 in the United Kingdom.", "negatives": ["Approximately 250,000 people are infected with human T-cell lymphotropic virus type 1 in the United Kingdom.", "Eilat virus (EILV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in nonhuman primates.", "Vaccinating the gastrointestinal tract induces protection of rectal and vaginal mucosa.", "MafA phosphorylation decreases its ubiquitination.", "Adult tissue-resident macrophages are seeded before birth.", "The origin of the CRF01_1b2k protein occurred between 1923 and 1956.", "Sequence conservation in gene regulatory regions between species is a poor predictor of conserved functionality.", "LRBA prevents CTLA - 4 recycling.", "Induction of urokinase receptor signaling in podocytes causes foot process effacement and proteinuria.", "Integrated care is ineffective at tackling multiple comorbidities."], "hard_negatives": ["Lice attenuated SIV vaccines induce a stronger antigen-specific T cell response in lymph node cells.", "Major antigen-induced signals from the T cell receptor and secondary signals from costimulatory receptors are required for T cell activation.", "CD28 signals regulate trafficking of murine auto-reactive T cells into target tissues.", "In pediatric tissue, most T cells are naive T cell emigrants from the thymus.", "A T helper 2 cell (Th2) environment impedes disease development in patients with systemic lupus erythematosus (SLE).", "Approximately 250,000 people are infected with human T-cell lymphotropic virus type 1 in the United Kingdom.", "IL-10 production by monocytes inhibits CD4 + T cell response.", "EG7 tumors can be killed by systemic oxaliplatin primed CD8+ T cells from the tumor-draining lymph node cells.", "Peroxynitrite is required for induction of T cell tolerance.", "Type 1 Diabetes is associated with subtle perturbations in T reg development."], "hard_negative": "Lice attenuated SIV vaccines induce a stronger antigen-specific T cell response in lymph node cells."}
{"query_id": "696", "query_text": "Lipopolysaccharides have an inflammation independent effect on kidney barrier function.", "negative": "Deletion of ATM and Rad3 related protein leads to acute tissue loss.", "negatives": ["Deletion of ATM and Rad3 related protein leads to acute tissue loss.", "Genes involved in pre-mRNA splicing have a significant impact on genome stability.", "A 100g dose of chloroquine chemoprophylactic regimen results in retinal toxicity after 5-6 years of weekly intake.", "Deltex interacts with eIF3. There is no known interaction between Deltex and elF3", "Upon viral challenge, influenza-specific memory CD4+ T cells greatly enhance the early production of inflammatory chemokines in the lung.", "Taking anti-depresents is associated with a decrease in the A\u03b2 level in the brain of experimental animals.", "ATM and Rad3 related protein are critical for sensing DNA damage.", "Cancer-associated fibroblasts (CAFs) have no known interaction with cancer cells in the formation and activation of CAFs.", "IL-10 production by monocytes inhibits CD4 + T cell response.", "N348I mutations reduce resistance to nevirapine."], "hard_negatives": ["Lipopolysaccharides have an inflammation independent effect on kidney barrier function.", "The effect of Lipopolysaccharides on kidney barrier function is dependent on inflammation levels.", "Angiotensin converting enzyme inhibitors are associated with decreased risk for functional renal insufficiency.", "AMP-activated protein kinase (AMPK) activation reduces inflammation-related fibrosis in the lungs.", "NAC destabilizes NO to increase the effect of contrast agents on renal functions.", "Reduced levels of lipolysis leads to higher P38 phosphorylation in adipose tissue.", "Increased lipolysis leads to higher P38 phosphorylation in adipose tissue.", "Inhibiting glucose-6-phospate dehydrogenase improves lipogenesis by deactivating LKB1-AMPK signaling.", "Myelin sheaths are lipid-rich cellular structures.", "Basophils promote disease development in patients with systemic lupus erythematosus (SLE)."], "hard_negative": "Lipopolysaccharides have an inflammation independent effect on kidney barrier function."}
{"query_id": "698", "query_text": "Lmna knock-in models are appropriate for testing therapeutic approaches against Hutchinson-Gilford progeria syndrome (HGPS).", "negative": "Malaria has a high vectorial capacity.", "negatives": ["Malaria has a high vectorial capacity.", "Converting apoE4 to apoE3 by gene editing prevents the pathology associated with apoE4 in human iPSCderived neurons.", "Pyridostatin encourages proliferation of homologous recombination - defective cells.", "Sympathetic nerve activity is reduced throughout normal pregnancy.", "DUSP4 increases apoptosis.", "Higher plasma levels of I-carnitine, when associated with trimethylamine N-oxide, are negatively correlated with cardiovascular events in humans.", "Osteocytes have an essential role in G-CSF induced HSPC mobilization.", "The NF-\u03baB essential modulator gene induces intestinal inflammation by promoting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death.", "Origin gross domestic product(GDP) is negatively related to dengue virus (DENV-1) diffusion in air traffic shipments.", "PGE 2 suppresss intestinal tumor growth by altering the expression of tumor suppressing and DNA repair genes."], "hard_negatives": ["Lmna knock-in models are appropriate for testing therapeutic approaches against Hutchinson-Gilford progeria syndrome (HGPS).", "Genomic sequences involved in alternative splicing responsible for Hutchinson-Gilford progeria syndrome (HGPS) are abundant in the ''progerinonly'' allele of Lmna knock-in models.", "Understanding epigenetic regulation of replication is essential for the reational design of episomally replicating vectors.", "Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission.", "Increased mobility of retrotransposons does not lead to mutation and higher tumorigenesis rates.", "Increased mobility of retrotransposons is assosciated with mutation and higher tumorigenesis rates.", "Genomic aberrations of metastases provide information for targeted therapy.", "Monoclonal antibody targeting of N-cadherin encourages metastasis.", "N348I mutations reduce resistance to nevirapine.", "HNF4A mutations are associated with macrosomia in infancy."], "hard_negative": "Lmna knock-in models are appropriate for testing therapeutic approaches against Hutchinson-Gilford progeria syndrome (HGPS)."}
{"query_id": "703", "query_text": "Localization of PIN1 in the roots of Arabidopsis requires VPS9a", "negative": "50% of patients exposed to radiation have activated markers of mesenchymal stem cells.", "negatives": ["50% of patients exposed to radiation have activated markers of mesenchymal stem cells.", "The tissue surrounding the granuloma in an immune cell induces an anti-inflammatory immune response.", "HOXB4 facilitates HSC expansion when co-cultured with HSCs.", "Pro-inflammatory cytokines are up repressed during tumor development.", "In domesticated populations of Saccharomyces cerevisiae, segmental aneuploidy occurs infrequently.", "Combination nicotine replacement therapies with varenicline or bupropion are more effective after 12 weeks of reatment compared to varenicline monotherapy.", "Reduced levels of lipolysis leads to higher P38 phosphorylation in adipose tissue.", "Enhanced early production of inflammatory chemokines damages viral control in the lung.", "Lice attenuated SIV vaccines induce a stronger antigen-specific T cell response in lymph node cells.", "LRBA prevents CTLA - 4 recycling."], "hard_negatives": ["Localization of PIN1 in the roots of Arabidopsis requires VPS9a", "LSD1-positive promoters are associated with RNA polymerase II", "Emodin forms hydrogen bonds with residues involved in PGAM1 substrate binding.", "taa1 tar1 tar2 triple mutants in Arabidopsis do not make root meristem during embryogenesis.", "Low expression of miR7a does not repress target genes or exert a biological function in ovaries.", "Removal of H3K9me3 by ectopic expression of other H3K9 demethylases improves reprogramming efficiency in SCNT experiments.", "Low expression of miR7a does not repress target genes or exert a biological function in testis.", "Removal of H3K9me3 by ectopic expression of other H3K9 demethylases decreases reprogramming efficiency in SCNT experiments.", "IFIT1 speeds viral replication by allowing for the proliferation of mis-capped viral RNAs.", "The artifactual C-terminal helix swapping in the StART domain is observed in the Ups1-Mdm35 heterodimer of the StARkin superfamily."], "hard_negative": "Localization of PIN1 in the roots of Arabidopsis requires VPS9a"}
{"query_id": "704", "query_text": "Long - range chromatin interactions regulate transcription.", "negative": "Cholesterol loading induces KLF4 expression in VSMCs, resulting in the expression of pro-inflammatory cytokines.", "negatives": ["Cholesterol loading induces KLF4 expression in VSMCs, resulting in the expression of pro-inflammatory cytokines.", "Foxk2 regulates autophagy genes in muscle cells and fibroblast cells.", "Destination container port throughput(CPT) is positively related to dengue virus (DENV-1) diffusion in air traffic shipments.", "The tip of the inner tube of the toxic type VI secretion system (T6SS) antibacterial effector in Escherichia coli (E. coli) is decorated with VgrG and PAAR proteins.", "Lack of FGF21 in mice leads to reduced lifespan.", "Ca2+ cycling is a UCP1-independent thermogenic mechanism.", "Women are more susceptible to death due to pneumonia when compared to men.", "Origin gross domestic product(GDP) is negatively related to dengue virus (DENV-1) diffusion in air traffic shipments.", "Klf2 is important for proper myeloid cell function.", "HbA1c consistently overestimates glycemic control in black individuals with Sickle cell trait (SCT)."], "hard_negatives": ["Long - range chromatin interactions regulate transcription.", "Distant CREs are important for transcriptional regulation.", "Cellular differentiation of embryonic stem cells is accompanied by changes in replication timing, transcription and nuclear localization.", "Sequence conservation in gene regulatory regions between species is a high-accuracy predictor of conserved functionality.", "Trans-acting factors, such as lncRNAs, influence mRNA translation.", "Genes involved in pre-mRNA splicing have a significant impact on genome stability.", "Cis-acting lncRNAs control the expression of genes that are positioned in the vicinity of their transcription sites.", "miRNAs regulate a unique suite of mRNAs to maintain homeostasis in cells.", "Mitochondria play a major role in energy production.", "Sequence conservation in gene regulatory regions between species is a poor predictor of conserved functionality."], "hard_negative": "Long - range chromatin interactions regulate transcription."}
{"query_id": "705", "query_text": "Long chain polyunsaturated fatty acids supplementation has no significant effects on wheezing or asthma at 3 and 6 years.", "negative": "Clathrin stabilizes the spindle fiber apparatus during mitosis.", "negatives": ["Clathrin stabilizes the spindle fiber apparatus during mitosis.", "Lamins are associated with nuclear membrane structure maintenance.", "FACT and other histone chaperone(s) compensate for Histone 2A (H2A)-histone 2B (H2B) dimer eviction during the histone exchange process.", "The risk of cancer rises with level of alcohol consumption.", "Patients in stable partnerships have a slower progression from HIV to AIDS.", "Bariatric surgery increases rates of colorectal cancer.", "The appearance of brown-like or beige cells primarily occurs in visceral fat, not subcutaneous fat.", "Increased flux of microbial products suppresses immune responses.", "Side effects associated with antidepressants lower risk of myocardial infarction.", "Integrating classroom-based collaborative learning with Web-based collaborative learning offers the best class performance."], "hard_negatives": ["Long chain polyunsaturated fatty acids supplementation has no significant effects on wheezing or asthma at 3 and 6 years.", "Long chain polyunsaturated fatty acids supplementation reduces wheezing and asthma.", "Long chain polyunsaturated fatty acids supplementation is associated with lower rates of atopic eczema at 1 year.", "Omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegans.", "Intake of folic acid (FA) and vitamin B6 (VB6) reduces levels of homocysteine.", "Omnivores produce less trimethylamine N-oxide from dietary I-carnitine than vegans.", "LDL cholesterol has a causal role in the development of cardiovascular disease.", "There is no increased risk of hypospadias with clomiphene.", "Intake of folic acid (FA) and vitamin B6 (VB6) increases levels of homocysteine.", "Vitamin D deficiency effects birth weight."], "hard_negative": "Long chain polyunsaturated fatty acids supplementation has no significant effects on wheezing or asthma at 3 and 6 years."}
{"query_id": "709", "query_text": "Long chain polyunsaturated fatty acids supplementation is associated with lower rates of atopic eczema at 1 year.", "negative": "APOE4 expression in iPSC-derived neurons results in decreased tau phosphorylation.", "negatives": ["APOE4 expression in iPSC-derived neurons results in decreased tau phosphorylation.", "ScPif1p has higher binding ability to G-rich ssDNA than to non-G-rich ssDNA.", "YAP/TAZ is required in intestinal regeneration in mouse models of ulcerative colitis.", "Citrullinated proteins externalized in neutrophil extracellular traps act indirectly to disrupt the inflammatory cycle.", "Pharmacist attendance at ward rounds reduces adverse events in wards.", "Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes fibrosis.", "Taking 400mg of \u03b1-tocopheryl acetate does not prevent prostate cancer.", "Post-transcriptional handling of mitochondrial transcripts occurs in mitochondrial RNA granules.", "The deamination of cytidine to uridine on the minus strand of viral DNA can inactivate the viral genome by inducing G-to-A mutations.", "Thiopurine active metabolites can be catabolized through dephosphorylation of thioguanine nucleotides."], "hard_negatives": ["Long chain polyunsaturated fatty acids supplementation is associated with lower rates of atopic eczema at 1 year.", "Long chain polyunsaturated fatty acids supplementation reduces wheezing and asthma.", "Long chain polyunsaturated fatty acids supplementation has no significant effects on wheezing or asthma at 3 and 6 years.", "LDL cholesterol has a causal role in the development of cardiovascular disease.", "Omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegans.", "Omnivores produce less trimethylamine N-oxide from dietary I-carnitine than vegans.", "Pioglitazone use is significantly associated with an increased risk of pancreatic cancer.", "There is no increased risk of hypospadias with clomiphene.", "Intake of folic acid (FA) and vitamin B6 (VB6) reduces levels of homocysteine.", "Intake of folic acid (FA) and vitamin B6 (VB6) increases levels of homocysteine."], "hard_negative": "Long chain polyunsaturated fatty acids supplementation is associated with lower rates of atopic eczema at 1 year."}
{"query_id": "710", "query_text": "Long chain polyunsaturated fatty acids supplementation reduces wheezing and asthma.", "negative": "The PRR MDA5 has a C-terminal domain.", "negatives": ["The PRR MDA5 has a C-terminal domain.", "There is no relation between Erythromycin use and hypertrophic pyloric stenosis.", "Origin gross domestic product(GDP) is positively related to dengue virus (DENV-1) diffusion in air traffic shipments.", "KRT17 modulates the expression of the transcriptional regulator AIRE in diseased epithelia.", "Cancer-associated fibroblasts (CAFs) are constituents of tumor microenvironments", "Satellite cell dysfunction is a key factor in sarcopenia development.", "Drosophila supracellular actomyosin structures are found at boundaries in wing imaginal discs.", "Pioneer factor OCT3/4 interacts with major chromatin remodeling factors.", "Lmna knock-in models are appropriate for testing therapeutic approaches against Hutchinson-Gilford progeria syndrome (HGPS).", "Human embryonic stem cells have the capacity to give rise to differentiated progeny representative of all three embryonic germ layers."], "hard_negatives": ["Long chain polyunsaturated fatty acids supplementation reduces wheezing and asthma.", "Long chain polyunsaturated fatty acids supplementation has no significant effects on wheezing or asthma at 3 and 6 years.", "Long chain polyunsaturated fatty acids supplementation is associated with lower rates of atopic eczema at 1 year.", "Omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegans.", "LDL cholesterol has a causal role in the development of cardiovascular disease.", "Intake of folic acid (FA) and vitamin B6 (VB6) reduces levels of homocysteine.", "Omnivores produce less trimethylamine N-oxide from dietary I-carnitine than vegans.", "Intake of folic acid (FA) and vitamin B6 (VB6) increases levels of homocysteine.", "Polymeal nutrition increases cardiovascular mortality.", "Omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegetarians."], "hard_negative": "Long chain polyunsaturated fatty acids supplementation reduces wheezing and asthma."}
{"query_id": "713", "query_text": "Low expression of miR7a does not repress target genes or exert a biological function in ovaries.", "negative": "Active H. pylori urease has a polymeric structure consisting of five distinct subunits.", "negatives": ["Active H. pylori urease has a polymeric structure consisting of five distinct subunits.", "Ca2+ cycling is a UCP1-independent thermogenic mechanism.", "There is no increased risk of hypospadias with clomiphene.", "siRNA knockdown of A20 slows tumor progression in an in vivo murine xenograft model.", "TRAP+ osteoclasts regulate mature osteoblast maintenance.", "Inhibiting focal adhesion formation enables cells to convert mechanical strain into eventual scarring.", "M. stadtmanae does not induce ASC speck formation in BlaER1 monocytes.", "Helminths interfere with immune system control of coinfections by microbial pathogens 16.", "Bone marrow cells don't contribute to adult macrophage compartments.", "Pioglitazone use is significantly associated with an increased risk of prostate cancer."], "hard_negatives": ["Low expression of miR7a does not repress target genes or exert a biological function in ovaries.", "Low expression of miR7a does not repress target genes or exert a biological function in testis.", "miRNAs regulate a unique suite of mRNAs to maintain homeostasis in cells.", "miRNAs enforce homeostasis by suppressing low-level ''leaky'' transcription.", "Major vault protein (MVP) leads to more aggressive tumors by regulating the sorting of tumor suppressive miR-193a into extracellular vesicles (EVs).", "TNFAIP3 is a glioblastoma tumor suppressor.", "TNFAIP3 is a glioblastoma tumor enhancer.", "TNFAIP3 is a tumor enhancer in glioblastoma.", "ALDH1 expression is associated with poorer prognosis for breast cancer primary tumors.", "MafA phosphorylation enhances its ubiquitination."], "hard_negative": "Low expression of miR7a does not repress target genes or exert a biological function in ovaries."}
{"query_id": "714", "query_text": "Low expression of miR7a does not repress target genes or exert a biological function in testis.", "negative": "De novo assembly of sequence data has shorter contigs than unassembled sequence data.", "negatives": ["De novo assembly of sequence data has shorter contigs than unassembled sequence data.", "Antidepressants reduce the severity of migraines.", "Adult tissue-resident macrophages possess a self-renewing capacity.", "Guanine nucleotide dissociation inhibitor (Rho-GDI) interacts with the p75 NTR death domain", "Fibroblast Growth Factor is a ligand which signals through receptor tyrosine kinases.", "Ca2+ cycling is a UCP1-dependent thermogenic mechanism.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have increased risk for Alzheimer's disease.", "qSOFA scores are associated with length of stay in emergency department patients.", "Side effects associated with antidepressants do not represent a mortality risk to postmenopausal women.", "Microglia are an innate immune cell type of the central nervous system."], "hard_negatives": ["Low expression of miR7a does not repress target genes or exert a biological function in testis.", "Low expression of miR7a does not repress target genes or exert a biological function in ovaries.", "miRNAs regulate a unique suite of mRNAs to maintain homeostasis in cells.", "miRNAs enforce homeostasis by suppressing low-level ''leaky'' transcription.", "Major vault protein (MVP) leads to more aggressive tumors by regulating the sorting of tumor suppressive miR-193a into extracellular vesicles (EVs).", "TNFAIP3 is a glioblastoma tumor suppressor.", "TNFAIP3 is a glioblastoma tumor enhancer.", "TNFAIP3 is a tumor enhancer in glioblastoma.", "R2D2 stops miRNA production by increasing the selectivity of Dcr2 for long dsRNA.", "ALDH1 expression is associated with poorer prognosis for breast cancer primary tumors."], "hard_negative": "Low expression of miR7a does not repress target genes or exert a biological function in testis."}
{"query_id": "717", "query_text": "Low nucleosome occupancy correlates with high methylation levels across species.", "negative": "Post-transcriptional handling of mitochondrial transcripts occurs in mitochondrial RNA granules.", "negatives": ["Post-transcriptional handling of mitochondrial transcripts occurs in mitochondrial RNA granules.", "In S. cerevisiae, the absence of RNA surveillance pathways causes sensitivity to high iron conditions.", "Thiopurine active metabolites can be catabolized through dephosphorylation of thioguanine nucleotides.", "V-9302 inhibits antitumor responses by decreasing cell death and oxidative stress.", "ART has no effect on the infectiveness of HIV-positive people.", "Nonhypertensive people who are 55 years old have a 90% chance of developing hypertension during their lifetime.", "Low expression of miR7a does not repress target genes or exert a biological function in ovaries.", "Clathrin stabilizes the spindle fiber apparatus during mitosis.", "Walking in traffic areas in London improves lung function in elderly adults.", "IgA plasma cells that are specific for transglutaminase 2 are scarce in the duodenal mucosa of celiac disease patients when the disease is active."], "hard_negatives": ["Low nucleosome occupancy correlates with high methylation levels across species.", "Sequence conservation in gene regulatory regions between species is a poor predictor of conserved functionality.", "Sequence conservation in gene regulatory regions between species is a high-accuracy predictor of conserved functionality.", "The generation of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells.", "The removal of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells.", "Pseudoknots are not evolutionarily conserved in most eukaryotes.", "miRNAs enforce homeostasis by suppressing low-level ''leaky'' transcription.", "Rapid phosphotransfer rates are correlated with histidine kinase regulator specificity.", "Long - range chromatin interactions regulate transcription.", "A deficiency of vitamin B12 decreases blood levels of homocysteine."], "hard_negative": "Low nucleosome occupancy correlates with high methylation levels across species."}
{"query_id": "724", "query_text": "Ly49Q directs the organization of neutrophil polarization by regulating membrane raft functions.", "negative": "ERAP1 SNPs are epistatic to HLA alleles for ankylosing spondylitis.", "negatives": ["ERAP1 SNPs are epistatic to HLA alleles for ankylosing spondylitis.", "PCSK9 inhibitors decrease plasma Lp(a) levels.", "Chlamydia trachomatis is most prevalent in the UK among sexually-experienced individuals aged 16 to 24.", "Chenodeoxycholic acid treatment increases brown adipose tissue activity.", "A single nucleotide variant the gene DGKK is strongly associated with increased risk of hypospadias.", "Pyridostatin induces double-strand breaks accumulation.", "Headaches are correlated with cognitive impairment.", "p16INK4A degradation is  linked to an abnormal wound response caused by the microinvasive step of advanced Oral Potentially Malignant Lesions (OPMLs).", "10% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.", "Mice defective for deoxyribonucleic acid (DNA) polymerase m (polm) fail to reveal increased sensitivity to ionizing radiation (IR)."], "hard_negatives": ["Ly49Q directs the organization of neutrophil polarization by regulating membrane raft functions.", "Active Ly49Q induces neutrophil polarization.", "Active Ly49Q prevents neutrophil polarization.", "Many transmembrane receptors transmit signals by long-range conformational changes in the association of alpha-helices across the plasma membrane.", "Kir7.1 modulates channel activity by the G protein-coupled melanocortin-4 receptor (MC4R) in the paraventricular nucleus of the hypothalamus.", "Intramembrane cleavage by signal peptide peptidase aids in the degradation of proteins with a complex membrane orientation.", "ITAM phosphorylation allows for the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).", "Active caspase-11 participate in regulating phagosome-lysosome fusion.", "miRNAs regulate a unique suite of mRNAs to maintain homeostasis in cells.", "JMJD6 slows the hydroxylation of C-terminal lysine"], "hard_negative": "Ly49Q directs the organization of neutrophil polarization by regulating membrane raft functions."}
{"query_id": "726", "query_text": "Ly6C hi monocytes have a higher inflammatory capacity than Ly6C lo monocytes.", "negative": "Healthy volunteers exhibit rapid and transient increase of cellular ATP after being bolus-injected with fructose.", "negatives": ["Healthy volunteers exhibit rapid and transient increase of cellular ATP after being bolus-injected with fructose.", "Deletion of ATM and Rad3 related protein leads to acute tissue loss.", "Including pharmacists in rounding teams does not alter the incidence of adverse drug events (ADEs).", "Activation of the Rac1 homolog CED-10 kills viable cells in SRGP-1 mutant Caenorhabditis elegans.", "H4 G94P proteins inhibit chromatin assembly, which decreases free histones.", "The removal of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells.", "Citrullinated proteins externalized in neutrophil extracellular traps act indirectly to disrupt the inflammatory cycle.", "Monoclonal antibody targeting of N-cadherin encourages metastasis.", "Myelin sheaths play a role in action potential propagation.", "Human embryonic stem cells have the capacity to give rise to differentiated progeny representative of all three embryonic germ layers."], "hard_negatives": ["Ly6C hi monocytes have a higher inflammatory capacity than Ly6C lo monocytes.", "Cancer-associated fibroblasts (CAFs) have no known interaction with cancer cells in the formation and activation of CAFs.", "The M2-phenotype in brown adipose tissue macrophages increases brown adipose tissue thermogenic activity.", "Bone marrow cells don't contribute to adult macrophage compartments.", "Cancer-associated fibroblasts (CAFs) interact with cancer cells to mediate formation and activation of CAFs.", "M. stadtmanae does not induce ASC speck formation in BlaER1 monocytes.", "Klf4 is important for proper myeloid cell differentiation.", "Induced hepatic stem cells possess the potential to differentiate into cholangiocytic cells.", "M. stadtmanae induces ASC speck formation in BlaER1 monocytes.", "The cytokine receptor which regulates chemotaxis and formation of lymph nodes is involved in production of myeloperoxidase in the left atrium."], "hard_negative": "Ly6C hi monocytes have a higher inflammatory capacity than Ly6C lo monocytes."}
{"query_id": "730", "query_text": "Lysine histone demethylase inhibitor JIB 04 is inactive against KDM5A.", "negative": "Incidence of 10/66 dementia is lower than the incidence of DSM-IV dementia.", "negatives": ["Incidence of 10/66 dementia is lower than the incidence of DSM-IV dementia.", "Energy balance requires hypothalamic glutamate neurotransmission.", "Pharmacist attendance at ward rounds increases adverse events in wards.", "Thiopurine active metabolites can be catabolized through dephosphorylation of thioguanine nucleotides.", "Increased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm.", "The innate immune response struggles to remove small numbers of parasites.", "Students who perform poorly in the early years of medical school are at increased risk for professional misconduct later in their careers.", "Medications to treat obesity are highly effective.", "Up-regulation of the p53 pathway and related molecular events speeds cancer progression.", "Antiretroviral therapy increases rates of tuberculosis across a broad range of CD4 strata."], "hard_negatives": ["Lysine histone demethylase inhibitor JIB 04 is inactive against KDM5A.", "JMJD6 slows the hydroxylation of C-terminal lysine", "Removal of H3K9me3 by ectopic expression of other H3K9 demethylases improves reprogramming efficiency in SCNT experiments.", "Removal of H3K9me3 by ectopic expression of other H3K9 demethylases decreases reprogramming efficiency in SCNT experiments.", "Guanine nucleotide dissociation inhibitor (Rho-GDI) interacts with the p75 NTR death domain", "Replacement of histone H2A with H2A.Z accelerates gene activation in yeasts by destabilizing +1 nucleosomes.", "C2 works synergistically with A-769662 to activate dephosphorylated AMPK.", "Smc5/6 engagment halts the activation of SUMO E3 ligase Mms21 by ATP-dependent remolding.", "B3-Galectin decreases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR.", "B3-Galectin increases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR."], "hard_negative": "Lysine histone demethylase inhibitor JIB 04 is inactive against KDM5A."}
{"query_id": "732", "query_text": "M. stadtmanae does not induce ASC speck formation in BlaER1 monocytes.", "negative": "Asymptomatic visual impairment screening in elderly populations leads to improved vision.", "negatives": ["Asymptomatic visual impairment screening in elderly populations leads to improved vision.", "\u03b2-sheet opening occurs during pleurotolysin pore formation.", "Many transmembrane receptors transmit signals by long-range conformational changes in the association of alpha-helices across the plasma membrane.", "The proliferative capacity of neural progenitors differs across species.", "Bariatric surgery leads to positive outcomes in mental health.", "Ultrasound guidance significantly reduces the number of needle insertion attempts necessary for a given procedure.", "Many transmembrane receptors transmit signals by long-range conformational changes in the association of alpha-helices across the plasma membrane.", "Patients with microcytosis and higher erythrocyte count are more vulnerable to severe malarial anaemia when infected with Plasmodium falciparum.", "Mutations in RIM1 raise levels of IME1 RNA.", "The morphology change from large white adipocytes to small brown adipocytes is a sign of increased energy expenditure potential in white adipose tissue."], "hard_negatives": ["M. stadtmanae does not induce ASC speck formation in BlaER1 monocytes.", "M. stadtmanae induces ASC speck formation in BlaER1 monocytes.", "Varying expression levels of EBI2 affect the positioning and migration of B cells.", "Ly6C hi monocytes have a higher inflammatory capacity than Ly6C lo monocytes.", "The deregulated and prolonged activation of monocytes has deleterious effects in chronic infectious conditions.", "GATA3 regulates cell cycle progression in bone marrow hematopoietic stem cells.", "PD-1 triggering on monocytes enhances IL-10 production by monocytes.", "GATA3 regulates self-renewal capacity in bone marrow hematopoietic stem cells.", "Klf4 is not required for proper myeloid cell differentiation.", "Activation of the Rac1 homolog CED-10 kills viable cells in SRGP-1 mutant Caenorhabditis elegans."], "hard_negative": "M. stadtmanae does not induce ASC speck formation in BlaER1 monocytes."}
{"query_id": "733", "query_text": "M. stadtmanae induces ASC speck formation in BlaER1 monocytes.", "negative": "Patients with common epithelial cancers  are more likely to have an emergency event as their first hospital admission if they live in resource-deprived areas.", "negatives": ["Patients with common epithelial cancers  are more likely to have an emergency event as their first hospital admission if they live in resource-deprived areas.", "Noninvasive positive pressure ventilation is not predictive of acute respiratory failure after solid organ transplantation.", "Chinese individuals with TT homozygosity in the MTHFR gene are more vulnerable to strokes caused by low levels of folate intake.", "Diminished ovarian reserve is a reliable indicator of infertility in a non-infertile population.", "Gastric infection with Helicobacter pylori increases risk of gastric cancer in humans.", "Pharmacist attendance at ward rounds reduces adverse events in wards.", "In melanoma, anti-CTLA-4 treatment reinvigorates exhausted PD-1+Eomes+CD8 T cells.", "Stiff substrates encourage mesodermal differentiation by degrading beta-catenin in an integrin-dependent manner.", "Polymeal nutrition increases cardiovascular mortality.", "H.pylori-mediated gastric cancer occurs due to the accumulation of mutations in host epithelial cells."], "hard_negatives": ["M. stadtmanae induces ASC speck formation in BlaER1 monocytes.", "M. stadtmanae does not induce ASC speck formation in BlaER1 monocytes.", "Varying expression levels of EBI2 affect the positioning and migration of B cells.", "Ly6C hi monocytes have a higher inflammatory capacity than Ly6C lo monocytes.", "GATA3 regulates cell cycle progression in bone marrow hematopoietic stem cells.", "PD-1 triggering on monocytes enhances IL-10 production by monocytes.", "The deregulated and prolonged activation of monocytes has deleterious effects in chronic infectious conditions.", "GATA3 regulates self-renewal capacity in bone marrow hematopoietic stem cells.", "Cancer cells can stimulate the accumulation of intra-tumoural myeloid-derived suppressor cells by promoting granulocyte colony stimulating factor production.", "Glioblastoma multiforme (GBM) is characterized by extensive invasion, rapid growth, necrosis, and angiogenesis."], "hard_negative": "M. stadtmanae induces ASC speck formation in BlaER1 monocytes."}
{"query_id": "734", "query_text": "MEK inhibitors are effective treatments in RAS-driven mouse models of cancer.", "negative": "Klf4 is not required for proper myeloid cell differentiation.", "negatives": ["Klf4 is not required for proper myeloid cell differentiation.", "Differentiation of progenitor cells to myeloid cells is skewed upon activation of insulin signaling.", "Recognition of start codons depends on the translation initiation factor IF3.", "Sudden death can occur in patients with complex ventricular arrhythmias.", "The C-type lectin receptor (CLEC-2) rearranges the actin cytoskeleton in dendritic cells to promote efficient motility along stromal surfaces.", "An M2-like phenotype in brown adipose tissue macrophages is quickly induced by cold exposure.", "Omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegans.", "Omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegetarians.", "taa1 tar1 tar2 triple mutants in Arabidopsis do not make root meristem during embryogenesis.", "NR5A2 is important in reverse cholesterol transport in humans."], "hard_negatives": ["MEK inhibitors are effective treatments in RAS-driven mouse models of cancer.", "TNFAIP3 is a glioblastoma tumor suppressor.", "Cancer-associated fibroblasts (CAFs) interact with cancer cells to mediate formation and activation of CAFs.", "Cancers that initially benefit from epidermal growth factor receptor targeted therapies later become refractory through several mechanisms.", "TNFAIP3 is a glioblastoma tumor enhancer.", "TNFAIP3 is a tumor enhancer in glioblastoma.", "Cancer-associated fibroblasts (CAFs) have no known interaction with cancer cells in the formation and activation of CAFs.", "DUSP4 downregulation deactivates the Ras-ERK pathway", "Upon developing tyrosine-kinase inhibitor resistance, new mutations in epidermal growth factor receptors emerge and cause treatment failure.", "Cancer-associated fibroblasts (CAFs) are constituents of tumor microenvironments"], "hard_negative": "MEK inhibitors are effective treatments in RAS-driven mouse models of cancer."}
{"query_id": "736", "query_text": "MFGE8 regulates fat absorption by binding to av-Beta3 and av-Beta5 integrins.", "negative": "CHOP is a general endoplasmic reticulum stress marker.", "negatives": ["CHOP is a general endoplasmic reticulum stress marker.", "Side effects associated with antidepressants do not represent a mortality risk to postmenopausal women.", "MEK inhibitors are effective treatments in RAS-driven mouse models of cancer.", "Increased microtubule acetylation exacerbates LRRK2 Roc-COR domain mutation induced locomotor deficits.", "DRD1 proteins enable Pol V transcription in vivo.", "Deregulation of HAND2 is a crucial step in endometrial carcinogenesis in mice.", "The C-type lectin receptor (CLEC-2) rearranges the actin cytoskeleton in dendritic cells to promote efficient motility along stromal surfaces.", "N348I mutations cause resistance to nevirapine.", "The mean suicide rate in women is lower after miscarriage than live birth.", "Participants who quit smoking reduce lung cancer risk by approximately 50%."], "hard_negatives": ["MFGE8 regulates fat absorption by binding to av-Beta3 and av-Beta5 integrins.", "MUC1-C activates the NF-\u03baB p65 signaling pathway by interacting with I\u03baB kinase \u00df.", "APOE4 expression in iPSC-derived neurons results in decreased tau phosphorylation.", "ATF4 is a general endoplasmic reticulum stress marker.", "Intake of folic acid (FA) and vitamin B6 (VB6) increases levels of homocysteine.", "Ca2+ cycling controls whole-body energy homeostasis in beige fat.", "Inhibiting glucose-6-phospate dehydrogenase improves lipogenesis by deactivating LKB1-AMPK signaling.", "Increased lipolysis leads to higher P38 phosphorylation in adipose tissue.", "Klf4 is important for proper myeloid cell differentiation.", "Reduced levels of lipolysis leads to higher P38 phosphorylation in adipose tissue."], "hard_negative": "MFGE8 regulates fat absorption by binding to av-Beta3 and av-Beta5 integrins."}
{"query_id": "737", "query_text": "MICAL redox enzymes regulate actin dynamics in many cell types.", "negative": "\u03b21/Ketel is able to bind microtubules.", "negatives": ["\u03b21/Ketel is able to bind microtubules.", "Reduction of purity of cytoplasmic membranes isolated from overexpressors is indicated by stronger spots for OmpF in 2D BN-PAGE gels.", "IFI16 impedes STING phosphorylation and translocation, resulting in reduced activation of STING.", "Nonsteroidal antinflammatory drugs show potential anticancer indications.", "Mitochondria play a major role in energy production.", "Lysine histone demethylase inhibitor JIB 04 is inactive against KDM5A.", "Normal granulomas form in the absence of TNF in Zebrafish.", "In transgenic mice harboring green florescent protein under the control of the Sox2 promoter, more than 50 percent of the cells with green florescent colocalize with cell proliferation markers.", "Cholesterol loading induces KLF4 expression in VSMCs, resulting in the expression of pro-inflammatory cytokines.", "Persistor cells are one reason for incomplete responses to Tyrosine kinase inhibitor (TKI) therapy in cancer patients."], "hard_negatives": ["MICAL redox enzymes regulate actin dynamics in many cell types.", "MICAL redox enzymes regulate actin dynamics.", "The C-type lectin receptor (CLEC-2) rearranges the actin cytoskeleton in dendritic cells to promote efficient motility along stromal surfaces.", "Oxidative phosphorylation is one of the primary glycometabolic pathways in cells.", "Mitochondria play a major role in energy production.", "Lamins are found within the inner layer of the mitochondrial membrane of all cells.", "Mitochondria play a trivial role in calcium homeostasis.", "Guanine nucleotide exchange factors (GEFs) mediate RhoA activation in response to tensional forces on fibronectin-binding integrins.", "Myelin sheaths play a role in action potential propagation.", "The Snf1 complex regulates carbon and energy metabolism in baker's yeast (Saccharomyces cerevisiae)."], "hard_negative": "MICAL redox enzymes regulate actin dynamics in many cell types."}
{"query_id": "738", "query_text": "MICAL redox enzymes regulate actin dynamics.", "negative": "ART has no effect on the infectiveness of HIV-positive people.", "negatives": ["ART has no effect on the infectiveness of HIV-positive people.", "The minor G allele of FOXO3 downregulates pro-inflammatory cytokines.", "The combination of physical examinations with C-reactive protein values do not improve the accuracy of radiographic verified pneumonia predictions.", "Ethanol stress increases the expression of PSP in bacteria.", "Active caspase-11 protein promotes pyroptosis.", "Removal of H3K9me3 by ectopic expression of other H3K9 demethylases decreases reprogramming efficiency in SCNT experiments.", "Oxidative phosphorylation is one of the primary glycometabolic pathways in cells.", "Pyridostatin induces double-strand breaks accumulation.", "Addition of BMP4, activin A, CHIR99021, and SU504 to reprogramming fibroblasts generates, expands and maintains cardiovascular progenitor cells (CPCs)", "Varenicline monotherapy is more effective after 26 weeks of treatment compared to combination nicotine replacement therapies with varenicline or bupropion."], "hard_negatives": ["MICAL redox enzymes regulate actin dynamics.", "MICAL redox enzymes regulate actin dynamics in many cell types.", "Guanine nucleotide exchange factors (GEFs) mediate RhoA activation in response to tensional forces on fibronectin-binding integrins.", "The C-type lectin receptor (CLEC-2) rearranges the actin cytoskeleton in dendritic cells to promote efficient motility along stromal surfaces.", "Oxidative phosphorylation is one of the primary glycometabolic pathways in cells.", "Deltex interacts with eIF3. There is no known interaction between Deltex and elF3", "Mitochondria play a major role in energy production.", "Mitochondria play a trivial role in calcium homeostasis.", "Ca2+ cycling controls whole-body energy homeostasis in beige fat.", "The Snf1 complex regulates carbon and energy metabolism in baker's yeast (Saccharomyces cerevisiae)."], "hard_negative": "MICAL redox enzymes regulate actin dynamics."}
{"query_id": "739", "query_text": "MT binding domain drives amyloid structure formation.", "negative": "One in two surgical randomized controlled trials are discontinued early.", "negatives": ["One in two surgical randomized controlled trials are discontinued early.", "Input from  mental and physical health care professionals is not effective at decreasing homelessness.", "Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission.", "Increased flux of microbial products provokes immune responses.", "CHOP is a general endoplasmic reticulum stress marker.", "Diabetes remission occurs more in people treated with conventional therapy than in people treated with laparoscopic adjustable gastric banding surgery.", "The TRaF1/C5 rs10818488 allele polymorphism regulates the neighboring C5 gene.", "Crossover hot spots are found within gene promoters in Saccharomyces cerevisiae.", "Early patent ductus ateriosus (PDA) screening decreases in-hospital mortality.", "EG7 tumors can be killed by systemic oxaliplatin primed CD8+ T cells from the tumor-draining lymph node cells."], "hard_negatives": ["MT binding domain drives amyloid structure formation.", "H4 G94P proteins inhibit chromatin assembly, which decreases free histones.", "H4 G94P proteins induce chromatin assembly, which increases free histones.", "H4 G94P proteins induce degradation of free histones via Rad53-dependent mechanisms.", "Cyclin A2 destruction is necessary to switch from unstable to stable kt-mt attachments in mitosis.", "Deletion of ATM and Rad3 related protein leads to acute tissue loss.", "TRAP+ osteoclasts regulate mature osteoblast maintenance.", "H4 G94P proteins suppress degradation of free histones via Rad53-dependent mechanisms.", "APOE4 expression in iPSC-derived neurons results in decreased tau phosphorylation.", "The microtubule-dependent delivery and secretion of matrix metalloproteases (MMPs) is partially responsible for the disassembly of adhesion sites."], "hard_negative": "MT binding domain drives amyloid structure formation."}
{"query_id": "740", "query_text": "MUC1-C activates the NF-\u03baB p65 signaling pathway by interacting with I\u03baB kinase \u00df.", "negative": "RANK-RANKL pathway signalling is linked to development of Aire-expressing medullary thymic epithelial cells.", "negatives": ["RANK-RANKL pathway signalling is linked to development of Aire-expressing medullary thymic epithelial cells.", "Chenodeoxycholic acid treatment increases brown adipose tissue activity.", "Allogeneic mechanical circulatory support is not as effective as autologous mechanical circulatory support for treating acute myocardial infarction.", "Intramembrane cleavage by signal peptide peptidase aids in the degradation of proteins with a complex membrane orientation.", "A T helper 2 cell (Th2) environment impedes disease development in patients with systemic lupus erythematosus (SLE).", "Pre-mRNAs associated with spliceosomal components are more stable than unassociated splicing substrates.", "Individuals with low serum vitamin D concentrations have decreased risk of multiple sclerosis.", "Homozygous deletion of murine Sbds gene from osterix-expressing mesenchymal stem and progenitor cells (MPCs) induces oxidative stress.", "Walking in traffic areas in London did not improve lung function in elderly adults.", "TNFAIP3 is a tumor enhancer in glioblastoma."], "hard_negatives": ["MUC1-C activates the NF-\u03baB p65 signaling pathway by interacting with I\u03baB kinase \u00df.", "The NF-\u03baB essential modulator gene induces intestinal inflammation by promoting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death.", "The NF-\u03baB essential modulator gene prevents intestinal inflammation by inhibiting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death.", "Mutations in G-Beta protein GNB1 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.", "p16INK4A degradation is encoded by CDKN2A.", "MFGE8 regulates fat absorption by binding to av-Beta3 and av-Beta5 integrins.", "TNFAIP3 is a glioblastoma tumor suppressor.", "Foxp3 represses the expression of transcriptional regulators implicated in memory T cell development.", "The Snf1 complex regulates carbon and energy metabolism in baker's yeast (Saccharomyces cerevisiae).", "Foxp3 enables the expression of transcriptional regulators implicated in memory T cell development."], "hard_negative": "MUC1-C activates the NF-\u03baB p65 signaling pathway by interacting with I\u03baB kinase \u00df."}
{"query_id": "745", "query_text": "MafA phosphorylation decreases its ubiquitination.", "negative": "Helicobacter pylori-induced aberrant NF-kB-dependent expression of activation-induced cytidine deaminase contributes to the mutagenesis of host DNA.", "negatives": ["Helicobacter pylori-induced aberrant NF-kB-dependent expression of activation-induced cytidine deaminase contributes to the mutagenesis of host DNA.", "Osteocytes have an essential role in G-CSF induced HSPC mobilization.", "MUC1-C activates the NF-\u03baB p65 signaling pathway by interacting with I\u03baB kinase \u00df.", "Mice defective for deoxyribonucleic acid (DNA) polymerase m (polm) reveal increased sensitivity to ionizing radiation (IR).", "Pioglitazone use is significantly associated with an increased risk of prostate cancer.", "Tirasemtiv targets cardiac muscle.", "Allogeneic mechanical circulatory support is not as effective as autologous mechanical circulatory support for treating acute myocardial infarction.", "Tuberculosis-induced granulomas express different immune system protein signatures than the surrounding tissue.", "Transplanted human glial progenitor cells can mature in their host animal.", "Pioglitazone use is significantly associated with an increased risk of prostate cancer."], "hard_negatives": ["MafA phosphorylation decreases its ubiquitination.", "MafA phosphorylation enhances its ubiquitination.", "MafA ubiquitination increases the recruitment of coavtivator P/CAF by MafA.", "MafA ubiquitination decreases the recruitment of coavtivator P/CAF by MafA.", "TNFAIP3 is a glioblastoma tumor suppressor.", "TNFAIP3 is a glioblastoma tumor enhancer.", "TNFAIP3 is a tumor enhancer in glioblastoma.", "Low expression of miR7a does not repress target genes or exert a biological function in ovaries.", "Upregulation of PD1 causes the downmodulation of Satb1.", "Mutations in RIM1 decrease levels of IME1 RNA."], "hard_negative": "MafA phosphorylation decreases its ubiquitination."}
{"query_id": "746", "query_text": "MafA phosphorylation enhances its ubiquitination.", "negative": "N348I mutations cause resistance to nevirapine.", "negatives": ["N348I mutations cause resistance to nevirapine.", "Immune complex triggered cell death leads to sequestration of oxidized mitochondrial DNA.", "Gpr124 increases BBB breakdown in mouse models of ischemic stroke.", "The Snf1 complex regulates carbon and energy metabolism in baker's yeast (Saccharomyces cerevisiae).", "Scapular stabilizer exercises are more effective than general exercise therapy in reducing pain and improving function of the shoulder.", "F4/80+ macrophages regulate mature osteoblast maintenance.", "Cnn1 recruitment varies with cell cycle timing.", "Repressing IL-18 has negative effects on atherosclerotic lesion composition and progression.", "Commelina yellow mottle virus (ComYMV) has three typical badnavirus ORFs, capable of encoding proteins 23, 15, and 216 kD.", "An M2-like phenotype in brown adipose tissue macrophages is quickly induced by cold exposure."], "hard_negatives": ["MafA phosphorylation enhances its ubiquitination.", "MafA phosphorylation decreases its ubiquitination.", "MafA ubiquitination increases the recruitment of coavtivator P/CAF by MafA.", "MafA ubiquitination decreases the recruitment of coavtivator P/CAF by MafA.", "TNFAIP3 is a glioblastoma tumor suppressor.", "TNFAIP3 is a glioblastoma tumor enhancer.", "TNFAIP3 is a tumor enhancer in glioblastoma.", "Low expression of miR7a does not repress target genes or exert a biological function in ovaries.", "Emodin forms hydrogen bonds with residues involved in PGAM1 substrate binding.", "Mutations in RIM1 decrease levels of IME1 RNA."], "hard_negative": "MafA phosphorylation enhances its ubiquitination."}
{"query_id": "747", "query_text": "MafA ubiquitination decreases the recruitment of coavtivator P/CAF by MafA.", "negative": "Side effects associated with antidepressants increases risk of stroke.", "negatives": ["Side effects associated with antidepressants increases risk of stroke.", "Activator-inhibitor pairs are provided ventrally by Xrl-sizzled.", "Increased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm.", "Primary cervical cytology screening with HPV detection has higher longitudinal sensitivity to detect severe cervical intraepithelial neoplasia than conventional cytology.", "Consumption of whole fruits increases the risk of type 2 diabetes.", "Mutations in RIM1 decrease levels of IME1 RNA.", "Sn is present on mature DCs during inflammation in vivo.", "LRBA prevents CTLA - 4 recycling.", "Fibroblast growth factor 21 protects against atherosclerosis by modulating adiponectin and SREBP2 levels.", "The innate immune response struggles to remove small numbers of parasites."], "hard_negatives": ["MafA ubiquitination decreases the recruitment of coavtivator P/CAF by MafA.", "MafA ubiquitination increases the recruitment of coavtivator P/CAF by MafA.", "MafA phosphorylation decreases its ubiquitination.", "MafA phosphorylation enhances its ubiquitination.", "The microtubule-dependent delivery and secretion of matrix metalloproteases (MMPs) is partially responsible for the disassembly of adhesion sites.", "Alirocumab treatment reduces apo(a) fractional clearance rate.", "Formation of N-terminal pyroglutamate by glutamine cyclase (GC) competes with NTAQ1 for Nt-Gln substrates.", "Emodin forms hydrogen bonds with residues involved in PGAM1 substrate binding.", "ScPif1p has reduced binding ability to G-rich ssDNA compared to non-G-rich ssDNA.", "ScPif1p has higher binding ability to G-rich ssDNA than to non-G-rich ssDNA."], "hard_negative": "MafA ubiquitination decreases the recruitment of coavtivator P/CAF by MafA."}
{"query_id": "748", "query_text": "MafA ubiquitination increases the recruitment of coavtivator P/CAF by MafA.", "negative": "Mouse models can be generated using \"artificial spermatids.\"", "negatives": ["Mouse models can be generated using \"artificial spermatids.\"", "The cytokine receptor which regulates chemotaxis and formation of lymph nodes is involved in production of myeloperoxidase in the left atrium.", "Reduction of purity of cytoplasmic membranes isolated from overexpressors is indicated by stronger spots for OmpA in 2D BN-PAGE gels.", "LSD1-positive promoters are associated with RNA polymerase II", "Deltex has no known interactions with eIF3f.", "Pure neural progenitor cell (NPC) populations can only be obtained from cell cultures that undergo passaging, filtration, or other isolation and cell sorting methods.", "Tirasemtiv targets cardiac muscle.", "Increase of p62 in prostate tumor stroma results in defective autophagy.", "Ethanol stress increases the expression of IBP in bacteria.", "MEK inhibitors are effective treatments in RAS-driven mouse models of cancer."], "hard_negatives": ["MafA ubiquitination increases the recruitment of coavtivator P/CAF by MafA.", "MafA ubiquitination decreases the recruitment of coavtivator P/CAF by MafA.", "MafA phosphorylation decreases its ubiquitination.", "MafA phosphorylation enhances its ubiquitination.", "The microtubule-dependent delivery and secretion of matrix metalloproteases (MMPs) is partially responsible for the disassembly of adhesion sites.", "Emodin forms hydrogen bonds with residues involved in PGAM1 substrate binding.", "Formation of N-terminal pyroglutamate by glutamine cyclase (GC) competes with NTAQ1 for Nt-Gln substrates.", "TNFAIP3 is a tumor enhancer in glioblastoma.", "TNFAIP3 is a glioblastoma tumor enhancer.", "Alirocumab treatment reduces apo(a) fractional clearance rate."], "hard_negative": "MafA ubiquitination increases the recruitment of coavtivator P/CAF by MafA."}
{"query_id": "749", "query_text": "Major antigen-induced signals from the T cell receptor and secondary signals from costimulatory receptors are required for T cell activation.", "negative": "Glioblastoma multiforme (GBM) is characterized by extensive invasion, rapid growth, necrosis, and angiogenesis.", "negatives": ["Glioblastoma multiforme (GBM) is characterized by extensive invasion, rapid growth, necrosis, and angiogenesis.", "Natriuretic peptides increase susceptibility to diabetes.", "Moderate consumption of candy and chocolate reduces the risk of cardiovascular disease (CVD).", "Medications to treat obesity have unwanted side effects.", "Including pharmacists in rounding teams reduces the incidence of adverse drug events (ADEs).", "Two variants of chromosome 6q21 are associated with radiation therapy-induced second malignancies in pediatric Hodgkin lymphoma patients.", "There is no association between HNF4A mutations and diabetes risks.", "Elevated cell-free mitochondrial DNA levels are associated with mortality.", "Aged patients are more susceptible to ischaemia/reperfusion injury.", "KLF4 is necessary for VSMCs to gain genetic characteristics of other cell types within atherosclerotic lesions."], "hard_negatives": ["Major antigen-induced signals from the T cell receptor and secondary signals from costimulatory receptors are required for T cell activation.", "CD28 signals regulate trafficking of murine auto-reactive T cells into target tissues.", "ITAM phosphorylation allows for the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).", "T cell receptor /CD3 microdomains are required to induce the immunologic synapse.", "CD28 initiates tonic signaling in conventional T cells, which causes an exhaustion phenotype and limited efficiency.", "Reduced responsiveness to interleukin-2 in regulatory T cells is associated with autoimmune diseases such as Type 1 Diabetes.", "Egr3 regulates the homeostasis of B and T cells.", "Egr2 regulates the homeostasis of B and T cells.", "Type 1 Diabetes is associated with subtle perturbations in T reg development.", "Peroxynitrite is required for induction of T cell tolerance."], "hard_negative": "Major antigen-induced signals from the T cell receptor and secondary signals from costimulatory receptors are required for T cell activation."}
{"query_id": "751", "query_text": "Major vault protein (MVP) leads to more aggressive tumors by regulating the sorting of tumor suppressive miR-193a into extracellular vesicles (EVs).", "negative": "Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection decreases dissemination of Salmonella Typhimurium from the gut.", "negatives": ["Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection decreases dissemination of Salmonella Typhimurium from the gut.", "Taxation of sugar-sweetened beverages reduced the incidence rate of type II diabetes in India.", "Lmna knock-in models are appropriate for testing therapeutic approaches against Hutchinson-Gilford progeria syndrome (HGPS).", "Increased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm.", "Comparative transcriptome analysis identified new platelet proteins with structural features suggesting a role in platelet function.", "Varenicline monotherapy is more effective after 26 weeks of treatment compared to combination nicotine replacement therapies with varenicline or bupropion.", "MICAL redox enzymes regulate actin dynamics in many cell types.", "Nonhypertensive people who are 55 years old have a 90% chance of developing hypertension during their lifetime.", "Cancer-associated fibroblasts (CAFs) interact with cancer cells to mediate formation and activation of CAFs.", "Bariatric surgery leads to negative outcomes in mental health."], "hard_negatives": ["Major vault protein (MVP) leads to more aggressive tumors by regulating the sorting of tumor suppressive miR-193a into extracellular vesicles (EVs).", "Major vault protein regulates sorting of tumor suppressive miR-193a into EVs.", "Low expression of miR7a does not repress target genes or exert a biological function in ovaries.", "Low expression of miR7a does not repress target genes or exert a biological function in testis.", "miRNAs regulate a unique suite of mRNAs to maintain homeostasis in cells.", "The PPR MDA5 has twenty N-terminal CARD domains.", "Glioblastoma multiforme (GBM) is characterized by extensive invasion, rapid growth, necrosis, and angiogenesis.", "Ly49Q directs the organization of neutrophil polarization by regulating membrane raft functions.", "Deletion of ATM and Rad3 related protein leads to acute tissue loss.", "Cancer-associated fibroblasts (CAFs) are constituents of tumor microenvironments"], "hard_negative": "Major vault protein (MVP) leads to more aggressive tumors by regulating the sorting of tumor suppressive miR-193a into extracellular vesicles (EVs)."}
{"query_id": "752", "query_text": "Major vault protein regulates sorting of tumor suppressive miR-193a into EVs.", "negative": "\u03b2-sheet opening occurs during pleurotolysin pore formation.", "negatives": ["\u03b2-sheet opening occurs during pleurotolysin pore formation.", "Energy balance requires hypothalamic glutamate neurotransmission.", "Bariatric surgery leads to positive outcomes in mental health.", "The H2A-H2B eviction defect is compensated for by other histone chaperone(s).", "Charcoal shows no benefit for acute paraquat poisoning.", "Differentiation of progenitor cells to myeloid cells is skewed upon activation of insulin signaling.", "Rapid phosphotransfer rates are correlated with histidine kinase regulator specificity.", "Increased microtubule acetylation repairs interference of axonal transport caused by LRRK2 Roc-COR domain mutations.", "Deleting Raptor increases G-CSF levels.", "A deficiency of vitamin B12 decreases blood levels of homocysteine."], "hard_negatives": ["Major vault protein regulates sorting of tumor suppressive miR-193a into EVs.", "Major vault protein (MVP) leads to more aggressive tumors by regulating the sorting of tumor suppressive miR-193a into extracellular vesicles (EVs).", "The PPR MDA5 has twenty N-terminal CARD domains.", "Low expression of miR7a does not repress target genes or exert a biological function in ovaries.", "Low expression of miR7a does not repress target genes or exert a biological function in testis.", "Deletion of ATM and Rad3 related protein leads to acute tissue loss.", "Active caspase-11 participate in regulating phagosome-lysosome fusion.", "miRNAs regulate a unique suite of mRNAs to maintain homeostasis in cells.", "Deletion of ATM and Rad3 related protein is not predictive of acute tissue loss.", "Activated Cdk5 phosphorylates the ATM protein in response to DNA damage."], "hard_negative": "Major vault protein regulates sorting of tumor suppressive miR-193a into EVs."}
{"query_id": "753", "query_text": "Malaria has a high vectorial capacity.", "negative": "Omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegetarians.", "negatives": ["Omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegetarians.", "Adult tissue-resident macrophages stem from the embryonal yolk sac and fetal liver.", "Ethanol stress lowers the expression of PSP in bacteria.", "Notch signaling occurs between tumor cells and stromal cells.", "MafA phosphorylation enhances its ubiquitination.", "The ability of activator E2Fs in preventing cell death is limited to terminally differentiated cells.", "At least 85% of patients exposed to radiation have activated markers of myofibroblasts.", "CD28 initiates tonic signaling in conventional T cells, which causes an exhaustion phenotype and limited efficiency.", "TMEM27 is a marker for beta cells.", "Roughly 55% of women with chronic pelvic pain have no underlying pathology."], "hard_negatives": ["Malaria has a high vectorial capacity.", "Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission.", "Rising temperatures caused by global warming lowers the risk of dengue fever transmission.", "Rising temperatures caused by global warming increases risk of dengue fever transmission.", "Eliminating the last sporadic cases of malaria requires considerable funding.", "Urbanization is an important risk factor related to the transmission of dengue fever.", "Nonhuman primates are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.", "Eilat virus (EILV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in nonhuman primates.", "The innate immune response struggles to remove small numbers of parasites.", "The World Health Organization's (WHO) data collection process is biased downward by unequal selection of larger outbreaks."], "hard_negative": "Malaria has a high vectorial capacity."}
{"query_id": "755", "query_text": "Many cytokines that are produced by cancer cells also contribute to carcinogenesis.", "negative": "Increased conversion of PGE 2 to PPARy ligand 15-ket-PGE 2 causes accumulation of PGE.", "negatives": ["Increased conversion of PGE 2 to PPARy ligand 15-ket-PGE 2 causes accumulation of PGE.", "Increased flux of microbial products provokes immune responses.", "Primary cervical cancer screening with HPV detection has lower longitudinal sensitivity than conventional cytology to detect cervical intraepithelial neoplasia grade 2.", "In breast cancer, the loss of myoepithelial cells promotes the transition of ductal carcinoma in situ to invasive carcinoma.", "Gastric infection with Helicobacter pylori increases risk of gastric cancer in humans.", "Bariatric surgery leads to positive outcomes in mental health.", "The DESMOND program demonstrates no significant impact on lifestyles outcomes.", "De novo assembly of sequence data has shorter contigs than unassembled sequence data.", "N348I mutations cause resistance to nevirapine.", "Mitochondria play a trivial role in calcium homeostasis."], "hard_negatives": ["Many cytokines that are produced by cancer cells also contribute to carcinogenesis.", "Cancer-associated fibroblasts (CAFs) interact with cancer cells to mediate formation and activation of CAFs.", "Pro-inflammatory cytokines are up regulated during tumor development.", "Cancer-associated fibroblasts (CAFs) have no known interaction with cancer cells in the formation and activation of CAFs.", "Tumor development occurs in conjunction with upregulation of pro-inflammatory cytokines.", "Cancers that initially benefit from epidermal growth factor receptor targeted therapies later become refractory through several mechanisms.", "Pro-inflammatory cytokines are up repressed during tumor development.", "Primary pro-inflammatory cytokines suppress secondary pro- and anti-inflammatory mediators.", "Up-regulation of the p53 pathway and related molecular events speeds cancer progression.", "In breast cancer, the loss of myoepithelial cells promotes the transition of ductal carcinoma in situ to invasive carcinoma."], "hard_negative": "Many cytokines that are produced by cancer cells also contribute to carcinogenesis."}
{"query_id": "757", "query_text": "Many transmembrane receptors transmit signals by long-range conformational changes in the association of alpha-helices across the plasma membrane.", "negative": "EGR2 is important to myelination of the peripheral nervous system.", "negatives": ["EGR2 is important to myelination of the peripheral nervous system.", "The most prevalent adverse events to Semaglutide are gastrointestinal.", "L3MBTL2 binds to H2AK119Ub marked chromatin to form a PRC1 complex.", "Mice that lack Interferon-\u03b3 or its receptor are highly susceptible to experimental autoimmune myocarditis.", "Binding of p53 to enhancer regions (p53BERs) regulates the activity of p53 transcription and cell cycle arrest through the production of p53-dependent eRNAs.", "40mg/day dosage of folic acid and 2mg/day dosage of vitamin B12 does not affect chronic kidney disease (CKD) progression.", "Kir7.1 modulates channel activity by the G protein-coupled melanocortin-4 receptor (MC4R) in the paraventricular nucleus of the hypothalamus.", "Chronic HIV stimulation of B cells leads to the premature exhaustion of B cells.", "Propriospinal interneurons that play a role in the plastic reorganization of spinal circuits are integral for recovery from spinal cord injury.", "PRC1-bound plasmids sediment at a slower rate in unbound plasmids than in sucrose gradients."], "hard_negatives": ["Many transmembrane receptors transmit signals by long-range conformational changes in the association of alpha-helices across the plasma membrane.", "Intramembrane cleavage by signal peptide peptidase aids in the degradation of proteins with a complex membrane orientation.", "Ly49Q directs the organization of neutrophil polarization by regulating membrane raft functions.", "ITAM phosphorylation allows for the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).", "Neutrophils produce IL-1\u03b2 in response to large particles.", "Major antigen-induced signals from the T cell receptor and secondary signals from costimulatory receptors are required for T cell activation.", "T cell receptor /CD3 microdomains are required to induce the immunologic synapse.", "The density of cytokine receptor bearing cells affects the distance over which cytokines act.", "TMEM27 is a marker for beta cells.", "The density of cytokine receptor bearing cells has no effect on the distance over which cytokines act."], "hard_negative": "Many transmembrane receptors transmit signals by long-range conformational changes in the association of alpha-helices across the plasma membrane."}
{"query_id": "758", "query_text": "Marmosets have a brain region homologous to Broca's area.", "negative": "Low expression of miR7a does not repress target genes or exert a biological function in ovaries.", "negatives": ["Low expression of miR7a does not repress target genes or exert a biological function in ovaries.", "Mice lacking Sirt1 in Sf1-expressing neurons are immune to diet-induced obesity and insulin resistance.", "Normal granulomas form in the presence of TNF in Zebrafish.", "The C-type lectin receptor (CLEC-2) rearranges the actin cytoskeleton in dendritic cells to promote efficient motility along stromal surfaces.", "There was an estimated 30 million cases of pneumonia in young children worldwide in 2010.", "Mouse models can be generated using \"artificial spermatids.\"", "Autophagy deficiency in the liver increases vulnerability to insulin resistance.", "Autologous transplantation of mesenchymal stem cells has better graft function than induction therapy with anti-interleukin-2 receptor antibodies.", "Genes involved in pre-mRNA splicing have a significant impact on genome stability.", "LDL cholesterol has a causal role in the development of cardiovascular disease."], "hard_negatives": ["Marmosets have a brain region homologous to Broca's area.", "Microglia are an innate immune cell type of the central nervous system.", "Microglia are an innate immune cell type of the peripheral nervous system.", "In rhesus macaques, daily subcutaneous injections of emtricitabine are ineffective at protecting against rectally transmitted simian-human immunodeficiency virus.", "Drosophila supracellular actomyosin structures are found at boundaries in wing imaginal discs.", "In rhesus macaques, daily subcutaneous injections of tenofovir protects against rectally transmitted simian-human immunodeficiency virus.", "The C-type lectin receptor (CLEC-2) rearranges the actin cytoskeleton in dendritic cells to promote efficient motility along stromal surfaces.", "Dscam1 acts as a hypervariable pattern-recognition receptor for the immune system.", "Occipital activation levels are associated with auditory spatial performance in parietal regions of the brain.", "Lamins are found within the inner layer of the mitochondrial membrane of all cells."], "hard_negative": "Marmosets have a brain region homologous to Broca's area."}
{"query_id": "760", "query_text": "Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission.", "negative": "Active caspase-11 participate in regulating phagosome-lysosome fusion.", "negatives": ["Active caspase-11 participate in regulating phagosome-lysosome fusion.", "Mice defective for deoxyribonucleic acid (DNA) polymerase m (polm) reveal increased sensitivity to ionizing radiation (IR).", "Klf4 is not required for proper myeloid cell differentiation.", "Beta-band coherence is enhanced for visible stimuli over invisible stimuli.", "Chemical injury represses transglutaminase 2 activity.", "Trans-acting factors, such as lncRNAs, influence mRNA translation.", "Long - range chromatin interactions regulate transcription.", "Rapamycin increases the concentration of triacylglycerols in fruit flies.", "Bariatric surgery reduces postmenopausal breast cancer.", "Helicobacter pylori-induced aberrant NF-kB-dependent expression of activation-induced cytidine deaminase contributes to the mutagenesis of host DNA."], "hard_negatives": ["Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission.", "Malaria has a high vectorial capacity.", "Antiretroviral therapy increases rates of tuberculosis across a broad range of CD4 strata.", "Eliminating the last sporadic cases of malaria requires considerable funding.", "Stroke patients with prior use of direct oral anticoagulants have a higher risk of in-hospital mortality than stroke patients with prior use of warfarin.", "Rising temperatures caused by global warming increases risk of dengue fever transmission.", "A breast cancer patient's capacity to metabolize tamoxifen influences treatment outcome.", "Rising temperatures caused by global warming lowers the risk of dengue fever transmission.", "Urbanization is an important risk factor related to the transmission of dengue fever.", "Patients with microcytosis and higher erythrocyte count are more vulnerable to severe malarial anaemia when infected with Plasmodium falciparum."], "hard_negative": "Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission."}
{"query_id": "761", "query_text": "MeCP2 influences the synaptic maturation of neurons.", "negative": "HbA1c consistently overestimates glycemic control in black individuals with Sickle cell trait (SCT).", "negatives": ["HbA1c consistently overestimates glycemic control in black individuals with Sickle cell trait (SCT).", "Understanding epigenetic regulation of replication is essential for the reational design of episomally replicating vectors.", "Basophils promote disease development in patients with systemic lupus erythematosus (SLE).", "ER-localized phosphatase Sac1 processes PI4P through coordination with OSBP and the endosome-localized protein sorting nexin 2.", "Side effects associated with antidepressants lower risk of myocardial infarction.", "The predominant localization of Linc00173 is in mononuclear macrophage nuclei.", "Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes epithelial damage.", "Differentiation of progenitor cells to myeloid cells is skewed when insulin signaling is suppressed.", "Ca2+ cycling is a UCP1-dependent thermogenic mechanism.", "Genes involved in pre-mRNA splicing have a significant impact on genome stability."], "hard_negatives": ["MeCP2 influences the synaptic maturation of neurons.", "Activation of PPM1D enhances p53 function.", "EGR2 is important to myelination of the peripheral nervous system.", "The proliferative capacity of neural progenitors differs across species.", "Mice lacking Sirt1 in Sf1-expressing neurons have increased susceptibility to diet-induced obesity and insulin resistance.", "HIV trans-activator protein (TAT) effectively transports large and small molecules across cellular membranes into larger populations of neurons.", "Converting apoE4 to apoE3 by gene editing prevents the pathology associated with apoE4 in human iPSCderived neurons.", "Converting apoE4 to apoE3 by gene editing worsens the pathology associated with apoE4 in human iPSCderived neurons.", "PKG-la plays an essential role in expression of spinal long term potentiation in PGK-la knockout mice.", "Mice lacking Sirt1 in Sf1-expressing neurons are immune to diet-induced obesity and insulin resistance."], "hard_negative": "MeCP2 influences the synaptic maturation of neurons."}
{"query_id": "762", "query_text": "Measuring routine outcomes is more beneficial to clinical practice than assessing treatment adherence.", "negative": "The proliferative capacity of progenitors is regulated cell-autonomously.", "negatives": ["The proliferative capacity of progenitors is regulated cell-autonomously.", "Higher plasma levels of I-carnitine, when associated with trimethylamine N-oxide, are positively correlated with cardiovascular events in humans.", "Mice lacking Sirt1 in Sf1-expressing neurons have increased susceptibility to diet-induced obesity and insulin resistance.", "Pediatric SCD patients with vaso-occlusive crisis show increased morphine use after breathing 80 ppm iNO for 4 hours.", "Deleting Raptor increases G-CSF levels.", "Increased mobility of retrotransposons does not lead to mutation and higher tumorigenesis rates.", "Mitochondria play a major role in apoptosis.", "Diabetes remission occurs less in people treated with conventional therapy than in people treated with laparoscopic adjustable gastric banding surgery.", "NR5A2 is important in reverse cholesterol transport in humans.", "Removal of H3K9me3 improves reprogramming efficiency in human somatic cell nuclear transfer experiments."], "hard_negatives": ["Measuring routine outcomes is more beneficial to clinical practice than assessing treatment adherence.", "Assessing treatment adherence is more beneficial to clinical practice than measuring routine outcomes.", "Cost effectiveness evaluations based on cRCT data accurately reflect prices for patients in actual clinical practice.", "Cost effectiveness evaluations based on cRCT data lack external validity.", "Including pharmacists in rounding teams does not alter the incidence of adverse drug events (ADEs).", "Including pharmacists in rounding teams reduces the incidence of adverse drug events (ADEs).", "Misunderstandings between doctors and patients can lead to non-adherence.", "Integrated care is ineffective at tackling multiple comorbidities.", "Integrated care is successful at tackling multiple comorbidities.", "Therapeutics receiving accelerated approval encounter a lower frequency of post-marketing safety events"], "hard_negative": "Measuring routine outcomes is more beneficial to clinical practice than assessing treatment adherence."}
{"query_id": "764", "query_text": "Medications to treat obesity are highly effective.", "negative": "Localization of PIN1 in the roots of Arabidopsis requires VPS9a", "negatives": ["Localization of PIN1 in the roots of Arabidopsis requires VPS9a", "PGE 2 suppresss intestinal tumor growth by altering the expression of tumor suppressing and DNA repair genes.", "40mg/day dosage of folic acid and 2mg/day dosage of vitamin B12 does not affect chronic kidney disease (CKD) progression.", "Forkhead 0 (fox0) transcription factors are involved in cellular differentiation.", "There is no relation between Erythromycin use and hypertrophic pyloric stenosis.", "MafA phosphorylation enhances its ubiquitination.", "Increased LDL receptors plays a role in the reduction of plasma Lp(a).", "The myocardial cell lineage originally develops from cardiac progenitors of exclusively endodermal origin.", "Increased LDL receptors plays a role in the reduction of plasma Lp(a).", "In breast cancer, the loss of myoepithelial cells slows the transition of ductal carcinoma in situ to invasive carcinoma."], "hard_negatives": ["Medications to treat obesity are highly effective.", "Medications to treat obesity do not have side effects.", "Medications to treat obesity have unwanted side effects.", "Excess gestational weight gain is associated with obesity-related pregnancy outcomes.", "Autophagy deficiency in the liver increases vulnerability to insulin resistance.", "Exercise increases cancer mortality rates among Chinese citizens.", "Exercise reduces cancer mortality rates among Chinese citizens.", "In young and middle-aged adults, current or remote uses of ADHD medications increase the risk of serious cardiovascular events.", "Insulin decreases risk of severe kidney failure.", "Antidepressants reduce the severity of migraines."], "hard_negative": "Medications to treat obesity are highly effective."}
{"query_id": "765", "query_text": "Medications to treat obesity do not have side effects.", "negative": "Nonsteroidal antinflammatory drugs show potential anticancer indications.", "negatives": ["Nonsteroidal antinflammatory drugs show potential anticancer indications.", "Consumption of whole fruits increases the risk of type 2 diabetes.", "Cognitive behavioral therapy is an ineffective treatment for insomnia", "Progerin induces premature aging in stem cells.", "The RANK-RANK-Ligand (RANKL) pathway is involved in the development of Aire-expressing medullary thymic epithelial cells (mTECs).", "Deletion of ATM and Rad3 related protein leads to acute tissue loss.", "mcm 5 s 2 U is required for proper decoding of NNR codons in eukaryotes.", "The World Health Organization's (WHO) data collection process is biased downward by unequal selection of larger outbreaks.", "76-85% of people with severe mental disorder receive no treatment in low and middle income countries.", "61% of colorectal cancer patients are diagnosed with regional or distant metastases."], "hard_negatives": ["Medications to treat obesity do not have side effects.", "Medications to treat obesity have unwanted side effects.", "Medications to treat obesity are highly effective.", "Excess gestational weight gain is associated with obesity-related pregnancy outcomes.", "Side effects associated with antidepressants do not represent a mortality risk to postmenopausal women.", "Side effects associated with antidepressants increases risk of stroke.", "Autophagy deficiency in the liver increases vulnerability to insulin resistance.", "In young and middle-aged adults, current or remote uses of ADHD medications increase the risk of serious cardiovascular events.", "Antidepressants reduce the severity of migraines.", "Sildenafil worsens erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants."], "hard_negative": "Medications to treat obesity do not have side effects."}
{"query_id": "766", "query_text": "Medications to treat obesity have unwanted side effects.", "negative": "The most prevalent adverse events to Semaglutide are gastrointestinal.", "negatives": ["The most prevalent adverse events to Semaglutide are gastrointestinal.", "There is a relation between Erythromycin use and hypertrophic pyloric stenosis.", "Major vault protein regulates sorting of tumor suppressive miR-193a into EVs.", "Nonhuman primates are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.", "Algerian physicians constitue the largest component of sub-Saharan Africa-trained physicians in the United States.", "In breast cancer, the loss of myoepithelial cells slows the transition of ductal carcinoma in situ to invasive carcinoma.", "Exposure to fine particulate air pollution is unrelated to anxiety prevalence.", "TMEM27 is a marker for beta cells.", "Induction of urokinase receptor signaling in podocytes causes foot process effacement and proteinuria.", "CD44v6 is not associated with constitutive and reprogrammed cancer stem cells driving cancer metastasis."], "hard_negatives": ["Medications to treat obesity have unwanted side effects.", "Medications to treat obesity do not have side effects.", "Medications to treat obesity are highly effective.", "Side effects associated with antidepressants increases risk of stroke.", "Excess gestational weight gain is associated with obesity-related pregnancy outcomes.", "Side effects associated with antidepressants do not represent a mortality risk to postmenopausal women.", "In young and middle-aged adults, current or remote uses of ADHD medications increase the risk of serious cardiovascular events.", "Autophagy deficiency in the liver increases vulnerability to insulin resistance.", "Antidepressants reduce the severity of migraines.", "Sildenafil worsens erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants."], "hard_negative": "Medications to treat obesity have unwanted side effects."}
{"query_id": "767", "query_text": "Men are more susceptible to death due to pneumonia when compared to women.", "negative": "Students who perform poorly in the early years of medical school are at increased risk for professional misconduct later in their careers.", "negatives": ["Students who perform poorly in the early years of medical school are at increased risk for professional misconduct later in their careers.", "British female students are bullied more than British male students.", "Charcoal shows no benefit for acute paraquat poisoning.", "Normal granulomas form in the absence of TNF in Zebrafish.", "Physical activity level is associated with the difference in maximal oxygen consumption between black and white youth.", "Scapular stabilizer exercises are more effective than general exercise therapy in reducing pain and improving function of the shoulder.", "A diminished ovarian reserve does not solely indicate infertility in an a priori non-infertile population.", "The NF-\u03baB essential modulator gene induces intestinal inflammation by promoting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death.", "eRNAs influence is linked to senescence, aging, and carcinogenesis.", "Tirasemtiv targets fast-twitch muscle."], "hard_negatives": ["Women are more susceptible to death due to pneumonia when compared to men.", "Men are more susceptible to death due to pneumonia when compared to women.", "There was an estimated 30 million cases of pneumonia in young children worldwide in 2010.", "The mean suicide rate in women is lower after miscarriage than live birth.", "The mean suicide rate in women is higher after miscarriage than live birth.", "Women with a lower birth weight are more likely to develop breast cancer later in life.", "Bacterial meningitis can be diagnosed on the basis of positive cerebrospinal fluid (CSF) cultures.", "Tuberculosis incidence occurs at higher rates in more sparsely populated areas in the UK.", "Rising temperatures caused by global warming increases risk of dengue fever transmission.", "Urbanization is an important risk factor related to the transmission of dengue fever."], "hard_negative": "Women are more susceptible to death due to pneumonia when compared to men."}
{"query_id": "771", "query_text": "Metastatic colorectal cancer treated with a single agent fluoropyrimidines resulted in similar efficacy and better quality of life when compared with oxaliplatin-based chemotherapy in elderly patients.", "negative": "taa1 tar1 tar2 triple mutants in Arabidopsis do not make root meristem during embryogenesis.", "negatives": ["taa1 tar1 tar2 triple mutants in Arabidopsis do not make root meristem during embryogenesis.", "Obesity raises life quality.", "Nonhuman primates are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.", "Occipital activation levels are associated with auditory spatial performance in parietal regions of the brain.", "Ethanol stress reduces the expression of SRL in bacteria.", "The PPR MDA5 has twenty N-terminal CARD domains.", "Antiretroviral therapy increases rates of tuberculosis across a broad range of CD4 strata.", "Primary cervical cancer screening with HPV detection has lower longitudinal sensitivity than conventional cytology to detect cervical intraepithelial neoplasia grade 2.", "HIV trans-activator protein (TAT) effectively transports large and small molecules across cellular membranes into larger populations of neurons.", "Ethanol stress increases the expression of PSP in bacteria."], "hard_negatives": ["Metastatic colorectal cancer treated with a single agent fluoropyrimidines resulted in similar efficacy and better quality of life when compared with oxaliplatin-based chemotherapy in elderly patients.", "61% of colorectal cancer patients are diagnosed with regional or distant metastases.", "The relationship between a breast cancer patient's capacity to metabolize tamoxifen and treatment outcome is independent of the patient's genetic make-up.", "1-1% of colorectal cancer patients are diagnosed with regional or distant metastases.", "Stroke patients with prior use of direct oral anticoagulants have a higher risk of in-hospital mortality than stroke patients with prior use of warfarin.", "Systemic immunosuppressive (IS) therapy increases the chance of cancer mortality in patients with inflammatory eye disease (IED)", "Systemic immunosuppressive (IS) therapy does not enhance the chance of cancer mortality in patients with inflammatory eye disease (IED)", "Varenicline monotherapy is more effective after 26 weeks of treatment compared to combination nicotine replacement therapies with varenicline or bupropion.", "Pioglitazone use is significantly associated with an increased risk of pancreatic cancer.", "A breast cancer patient's capacity to metabolize tamoxifen influences treatment outcome."], "hard_negative": "Metastatic colorectal cancer treated with a single agent fluoropyrimidines resulted in similar efficacy and better quality of life when compared with oxaliplatin-based chemotherapy in elderly patients."}
{"query_id": "772", "query_text": "Mice are incapable of producing neutralizing antibodies in reponse to the Chikungunya virus (CHIKV) produced in mosquitos.", "negative": "Egr2 regulates the homeostasis of B and T cells.", "negatives": ["Egr2 regulates the homeostasis of B and T cells.", "Fibroblast Growth Factor is a ligand which signals through receptor tyrosine kinases.", "Upon viral challenge, influenza-specific memory CD4+ T cells greatly enhance the early production of inflammatory chemokines in the lung.", "The amount of publicly available DNA data doubles every 10 months.", "Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 inhibit West Nile virus replication in cortical neurons.", "Rhythmic expression of Cry1 translates directly into a circadian regulation of cAMP signaling in gluconeogenesis.", "Pyridostatin induces checkpoint activation.", "Inhibiting HDAC6 increases survival of mice with ARID1A mutated tumors.", "R2D2 stops miRNA production by increasing the selectivity of Dcr2 for long dsRNA.", "Human embryonic stem cells give rise to cell types from all three embryonic germ layers."], "hard_negatives": ["Mice are incapable of producing neutralizing antibodies in reponse to the Chikungunya virus (CHIKV) produced in mosquitos.", "Nonhuman primates are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.", "Eilat virus (EILV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in nonhuman primates.", "Tuberculosis-induced granulomas express different immune system protein signatures than the surrounding tissue.", "Malaria has a high vectorial capacity.", "Rising temperatures caused by global warming increases risk of dengue fever transmission.", "Rising temperatures caused by global warming lowers the risk of dengue fever transmission.", "In rhesus macaques, daily subcutaneous injections of emtricitabine are ineffective at protecting against rectally transmitted simian-human immunodeficiency virus.", "Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission.", "Inside the body, falciparum parasites reproduce asexually."], "hard_negative": "Mice are incapable of producing neutralizing antibodies in reponse to the Chikungunya virus (CHIKV) produced in mosquitos."}
{"query_id": "774", "query_text": "Mice defective for deoxyribonucleic acid (DNA) polymerase I (polI) fail to reveal increased sensitivity to ionizing radiation (IR).", "negative": "Long chain polyunsaturated fatty acids supplementation is associated with lower rates of atopic eczema at 1 year.", "negatives": ["Long chain polyunsaturated fatty acids supplementation is associated with lower rates of atopic eczema at 1 year.", "The G34R/V mutation creates a hypomethylated phenotype at the H3K36 histone.", "Omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegans.", "M. stadtmanae does not induce ASC speck formation in BlaER1 monocytes.", "RA activation of DIF2 and NB4 cells induces hallmarks of transcriptionally active promoters.", "Pioglitazone use is significantly associated with an increased risk of pancreatic cancer.", "Inhibiting glucose-6-phospate dehydrogenase improves lipogenesis by deactivating LKB1-AMPK signaling.", "taa1 tar1 tar2 triple mutants in Arabidopsis do not make root meristem during embryogenesis.", "In pediatric tissue, most T cells are naive T cell emigrants from the thymus.", "COPI coatmer is involved in viral replication."], "hard_negatives": ["Mice defective for deoxyribonucleic acid (DNA) polymerase I (polI) fail to reveal increased sensitivity to ionizing radiation (IR).", "Mice defective for deoxyribonucleic acid (DNA) polymerase m (polm) fail to reveal increased sensitivity to ionizing radiation (IR).", "Mice defective for deoxyribonucleic acid (DNA) polymerase m (polm) reveal increased sensitivity to ionizing radiation (IR).", "PrimPol degrades short DNA replication intermediates on the leading strand during DNA replication.", "The deamination of cytidine to uridine on the minus strand of viral DNA can inactivate the viral genome by inducing G-to-A mutations.", "PrimPol generates short DNA replication intermediates on the leading strand during DNA replication.", "p16INK4A degradation is  linked to an abnormal wound response caused by the microinvasive step of advanced Oral Potentially Malignant Lesions (OPMLs).", "Neutrophils produce IL-1\u03b2 in response to large particles.", "Higher plasma levels of I-carnitine, when associated with trimethylamine N-oxide, are negatively correlated with cardiovascular events in humans.", "Reduction of purity of cytoplasmic membranes isolated from overexpressors is indicated by stronger spots for OmpA in 2D BN-PAGE gels."], "hard_negative": "Mice defective for deoxyribonucleic acid (DNA) polymerase I (polI) fail to reveal increased sensitivity to ionizing radiation (IR)."}
{"query_id": "776", "query_text": "Mice defective for deoxyribonucleic acid (DNA) polymerase m (polm) fail to reveal increased sensitivity to ionizing radiation (IR).", "negative": "The HSV-2 infection is typically asymptomatic.", "negatives": ["The HSV-2 infection is typically asymptomatic.", "Tonic signaling from the scFv is amplified by MyD88/CD40.", "7-day-old adult Caenorhabditis elegans exhibit approximately 5% of the learning capacity seen in 1-day old adults.", "mcm 5 s 2 U is required for proper decoding of NNR codons in eukaryotes.", "Decrease of p62 in prostate tumor stroma results in defective autophagy.", "Immune responses in immune cells are geographically segregated.", "Monoclonal antibody targeting of N-cadherin encourages metastasis.", "Major antigen-induced signals from the T cell receptor and secondary signals from costimulatory receptors are required for T cell activation.", "Bariatric surgery increases rates of postmenopausal breast cancer.", "Inhibiting glucose-6-phospate dehydrogenase improves lipogenesis by deactivating LKB1-AMPK signaling."], "hard_negatives": ["Mice defective for deoxyribonucleic acid (DNA) polymerase m (polm) fail to reveal increased sensitivity to ionizing radiation (IR).", "Mice defective for deoxyribonucleic acid (DNA) polymerase I (polI) fail to reveal increased sensitivity to ionizing radiation (IR).", "Mice defective for deoxyribonucleic acid (DNA) polymerase m (polm) reveal increased sensitivity to ionizing radiation (IR).", "PrimPol degrades short DNA replication intermediates on the leading strand during DNA replication.", "PrimPol generates short DNA replication intermediates on the leading strand during DNA replication.", "Reduction of purity of cytoplasmic membranes isolated from overexpressors is indicated by stronger spots for OmpA in 2D BN-PAGE gels.", "The deamination of cytidine to uridine on the minus strand of viral DNA can inactivate the viral genome by inducing G-to-A mutations.", "p16INK4A degradation is  linked to an abnormal wound response caused by the microinvasive step of advanced Oral Potentially Malignant Lesions (OPMLs).", "Lamins have no effect on nuclear membrane structure maintenance.", "R2D2 stops miRNA production by increasing the selectivity of Dcr2 for long dsRNA."], "hard_negative": "Mice defective for deoxyribonucleic acid (DNA) polymerase m (polm) fail to reveal increased sensitivity to ionizing radiation (IR)."}
{"query_id": "777", "query_text": "Mice defective for deoxyribonucleic acid (DNA) polymerase m (polm) reveal increased sensitivity to ionizing radiation (IR).", "negative": "ER-localized phosphatase Sac1 processes PI4P through coordination with OSBP and the endosome-localized protein sorting nexin 2.", "negatives": ["ER-localized phosphatase Sac1 processes PI4P through coordination with OSBP and the endosome-localized protein sorting nexin 2.", "Klf2 is important for proper myeloid cell function.", "Approximately 250,000 people are infected with human T-cell lymphotropic virus type 1 in the United Kingdom.", "Foxp3 represses the expression of transcriptional regulators implicated in memory T cell development.", "Long chain polyunsaturated fatty acids supplementation has no significant effects on wheezing or asthma at 3 and 6 years.", "There is no relation between Erythromycin use and hypertrophic pyloric stenosis.", "Many cytokines that are produced by cancer cells also contribute to carcinogenesis.", "Suboptimal nutrition is a leading cause of premature death", "DUSP4 increases apoptosis.", "Angiotensin converting enzyme inhibitors are associated with decreased risk for functional renal insufficiency."], "hard_negatives": ["Mice defective for deoxyribonucleic acid (DNA) polymerase m (polm) reveal increased sensitivity to ionizing radiation (IR).", "Mice defective for deoxyribonucleic acid (DNA) polymerase m (polm) fail to reveal increased sensitivity to ionizing radiation (IR).", "Mice defective for deoxyribonucleic acid (DNA) polymerase I (polI) fail to reveal increased sensitivity to ionizing radiation (IR).", "PrimPol degrades short DNA replication intermediates on the leading strand during DNA replication.", "PrimPol generates short DNA replication intermediates on the leading strand during DNA replication.", "p16INK4A degradation is  linked to an abnormal wound response caused by the microinvasive step of advanced Oral Potentially Malignant Lesions (OPMLs).", "Reduction of purity of cytoplasmic membranes isolated from overexpressors is indicated by stronger spots for OmpA in 2D BN-PAGE gels.", "Lamins have no effect on nuclear membrane structure maintenance.", "The deamination of cytidine to uridine on the minus strand of viral DNA can inactivate the viral genome by inducing G-to-A mutations.", "Reduction of purity of cytoplasmic membranes isolated from overexpressors is indicated by stronger spots for OmpF in 2D BN-PAGE gels."], "hard_negative": "Mice defective for deoxyribonucleic acid (DNA) polymerase m (polm) reveal increased sensitivity to ionizing radiation (IR)."}
{"query_id": "778", "query_text": "Mice lacking Sirt1 in Sf1-expressing neurons are immune to diet-induced obesity and insulin resistance.", "negative": "Integrated care is successful at tackling multiple comorbidities.", "negatives": ["Integrated care is successful at tackling multiple comorbidities.", "Genomic sequences involved in alternative splicing responsible for Hutchinson-Gilford progeria syndrome (HGPS) are abundant in the ''progerinonly'' allele of Lmna knock-in models.", "Bcp1 is a chaperone for Rpl23.", "In rhesus macaques, daily subcutaneous injections of tenofovir protects against rectally transmitted simian-human immunodeficiency virus.", "Post-transcriptional handling of mitochondrial transcripts occurs in mitochondrial RNA granules.", "Pyridostatin prevents double-strand breaks accumulation.", "Omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegans.", "Glucose restriction to 0.05% reduces RLS (replicative life span) by 20-40% in S. cerevisiae.", "Therapeutics receiving accelerated approval encounter a lower frequency of post-marketing safety events", "Sepsis related mortality has risen from 2009 to 2014."], "hard_negatives": ["Mice lacking Sirt1 in Sf1-expressing neurons are immune to diet-induced obesity and insulin resistance.", "Mice lacking Sirt1 in Sf1-expressing neurons have increased susceptibility to diet-induced obesity and insulin resistance.", "Mutant mice lacking SVCT2 have severely reduced ascorbic acid levels in both brain and adrenals.", "Autophagy deficiency in the liver increases vulnerability to insulin resistance.", "Lack of FGF21 in mice leads to reduced lifespan.", "Lack of FGF21 in mice increases life expectancy.", "HIV trans-activator protein (TAT) effectively transports large and small molecules across cellular membranes into larger populations of neurons.", "Lack of FGF21 in mice leads to atherosclerotic plaque formation.", "Lack of FGF21 in mice slows the rate of atherosclerotic plaque formation.", "Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes fibrosis."], "hard_negative": "Mice lacking Sirt1 in Sf1-expressing neurons are immune to diet-induced obesity and insulin resistance."}
{"query_id": "779", "query_text": "Mice lacking Sirt1 in Sf1-expressing neurons have increased susceptibility to diet-induced obesity and insulin resistance.", "negative": "The deamination of cytidine to uridine on the minus strand of viral DNA can inactivate the viral genome by inducing G-to-A mutations.", "negatives": ["The deamination of cytidine to uridine on the minus strand of viral DNA can inactivate the viral genome by inducing G-to-A mutations.", "Aged patients are more susceptible to ischaemia/reperfusion injury.", "Satellite cell dysfunction is a key factor in sarcopenia development.", "Pseudoknots are not evolutionarily conserved in most eukaryotes.", "The proportion of people with visual difficulty is two times higher in low-income countries than in high-income countries.", "Charcoal is an effective treatment for acute paraquat poisoning.", "Tonic signaling from the scFv induces constitutive stimulation.", "There is a relation between Erythromycin use and hypertrophic pyloric stenosis.", "Mice are incapable of producing neutralizing antibodies in reponse to the Chikungunya virus (CHIKV) produced in mosquitos.", "The morphology change from large white adipocytes to small brown adipocytes is a sign of decreased energy expenditure potential in white adipose tissue."], "hard_negatives": ["Mice lacking Sirt1 in Sf1-expressing neurons have increased susceptibility to diet-induced obesity and insulin resistance.", "Mice lacking Sirt1 in Sf1-expressing neurons are immune to diet-induced obesity and insulin resistance.", "Autophagy deficiency in the liver increases vulnerability to insulin resistance.", "Mutant mice lacking SVCT2 have severely reduced ascorbic acid levels in both brain and adrenals.", "Lack of FGF21 in mice increases life expectancy.", "Lack of FGF21 in mice leads to reduced lifespan.", "Lack of FGF21 in mice leads to atherosclerotic plaque formation.", "Lack of FGF21 in mice slows the rate of atherosclerotic plaque formation.", "Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes fibrosis.", "HIV trans-activator protein (TAT) effectively transports large and small molecules across cellular membranes into larger populations of neurons."], "hard_negative": "Mice lacking Sirt1 in Sf1-expressing neurons have increased susceptibility to diet-induced obesity and insulin resistance."}
{"query_id": "780", "query_text": "Mice that lack Interferon-\u03b3 or its receptor are highly susceptible to experimental autoimmune myocarditis.", "negative": "The origin of the CRF01_1b2k protein occurred between 1923 and 1956.", "negatives": ["The origin of the CRF01_1b2k protein occurred between 1923 and 1956.", "Physical activity level has no association with the difference in maximal oxygen consumption between black and white youth.", "CDK6 shows improved binding to loss-of-function variants of p18 INK4C.", "The mean suicide rate in women is lower after miscarriage than live birth.", "Major antigen-induced signals from the T cell receptor and secondary signals from costimulatory receptors are required for T cell activation.", "The mean suicide rate in women is higher after miscarriage than live birth.", "Reducing H3k4me3 methylation induces mouse epiblast stem cells to naive pluripotency efficiently.", "Many cytokines that are produced by cancer cells also contribute to carcinogenesis.", "Elevated cell-free mitochondrial DNA levels are associated with mortality.", "Active caspase-11 protein promotes pyroptosis."], "hard_negatives": ["Mice that lack Interferon-\u03b3 or its receptor are highly susceptible to experimental autoimmune myocarditis.", "Mice without IFN-\u03b3 or its receptor are highly susceptible to EAM induced with \u03b1-MyHC/CFA.", "In patients with congenital heart defects, \u03b2-blockers significantly improve clinical heart failure outcomes.", "The latent infection of myeloid cells with human cytomegalovirus induces a number of changes in gene expression.", "Reduced responsiveness to interleukin-2 in regulatory T cells is associated with autoimmune diseases such as Type 1 Diabetes.", "Diabetic patients with acute coronary syndrome experience decreased short-term and long-term risk for bleeding events.", "IL-6 signaling plays a major role in atherosclerotic cardiovascular disease.", "Gpr124 suppresses BBB breakdown in mouse models of ischemic stroke.", "High levels of CRP lead to a higher risk of exacerbations in chronic obstructive pulmonary disease (COPD).", "The minor G allele of FOXO3 downregulates pro-inflammatory cytokines."], "hard_negative": "Mice that lack Interferon-\u03b3 or its receptor are highly susceptible to experimental autoimmune myocarditis."}
{"query_id": "782", "query_text": "Mice without IFN-\u03b3 or its receptor are highly susceptible to EAM induced with \u03b1-MyHC/CFA.", "negative": "p16INK4A degradation is  linked to an abnormal wound response caused by the microinvasive step of advanced Oral Potentially Malignant Lesions (OPMLs).", "negatives": ["p16INK4A degradation is  linked to an abnormal wound response caused by the microinvasive step of advanced Oral Potentially Malignant Lesions (OPMLs).", "4-PBA treatment decreases endoplasmic reticulum stress in response to general endoplasmic reticulum stress markers.", "Misunderstandings between doctors and patients can lead to non-adherence.", "G-CSF increases the expansion and infiltration of MDSCs into tumors.", "Measuring routine outcomes is more beneficial to clinical practice than assessing treatment adherence.", "Roughly 55% of women with chronic pelvic pain have no underlying pathology.", "Upon developing tyrosine-kinase inhibitor resistance, new mutations in epidermal growth factor receptors emerge and cause treatment failure.", "Varenicline monotherapy is more effective after 26 weeks of treatment compared to combination nicotine replacement therapies with varenicline or bupropion.", "Propriospinal interneurons that play a role in the plastic reorganization of spinal circuits are integral for recovery from spinal cord injury.", "Whole brain radiotherapy increases the occurrence of new brain metastases."], "hard_negatives": ["Mice without IFN-\u03b3 or its receptor are highly susceptible to EAM induced with \u03b1-MyHC/CFA.", "Mice that lack Interferon-\u03b3 or its receptor are highly susceptible to experimental autoimmune myocarditis.", "Gpr124 suppresses BBB breakdown in mouse models of ischemic stroke.", "Gpr124 increases BBB breakdown in mouse models of ischemic stroke.", "The minor G allele of FOXO3 up-regulates IL-10.", "Taking anti-depresents is associated with a decrease in the A\u03b2 level in the brain of experimental animals.", "FoxO3a activation in neuronal death is inhibited by reactive oxygen species (ROS).", "Exposure to fine particulate air pollution is unrelated to anxiety prevalence.", "High levels of CRP lead to a higher risk of exacerbations in chronic obstructive pulmonary disease (COPD).", "HNF4A mutations are associated with macrosomia in infancy."], "hard_negative": "Mice without IFN-\u03b3 or its receptor are highly susceptible to EAM induced with \u03b1-MyHC/CFA."}
{"query_id": "787", "query_text": "Microcin J25 encourages nucleoside triphosphate (NTP) binding.", "negative": "CHOP is a general endoplasmic reticulum stress marker.", "negatives": ["CHOP is a general endoplasmic reticulum stress marker.", "Persistor cells are one reason for incomplete responses to Tyrosine kinase inhibitor (TKI) therapy in cancer patients.", "VgrG (Tssl) protein punctures membranes by forming a spike at the tip of the tube apparatus.", "p16INK4A degradation is  linked to an abnormal wound response caused by the microinvasive step of advanced Oral Potentially Malignant Lesions (OPMLs).", "Transplanted human glial progenitor cells can mature in their host animal.", "Anthrax spores remain deadly until affected areas are decontaminated.", "Bacterial meningitis can be diagnosed on the basis of positive cerebrospinal fluid (CSF) cultures.", "Men are more susceptible to death due to pneumonia when compared to women.", "ScPif1p has reduced binding ability to G-rich ssDNA compared to non-G-rich ssDNA.", "NAC inhibits the generation of angiotensin-converting enzyme."], "hard_negatives": ["Microcin J25 encourages nucleoside triphosphate (NTP) binding.", "Microcin J25 inhibits nucleoside triphosphate (NTP) binding.", "Bcp1 is a chaperone for Rpl23.", "Broadly HIV-1 Neutralizing Antibodies (bnAb) 10EB have no affinity for phospholipids.", "Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 encourage West Nile virus replication in cortical neurons.", "mcm 5 s 2 U is required for proper decoding of NNR codons in eukaryotes.", "MUC1-C activates the NF-\u03baB p65 signaling pathway by interacting with I\u03baB kinase \u00df.", "The Snf1 complex regulates carbon and energy metabolism in baker's yeast (Saccharomyces cerevisiae).", "Lack of FGF21 in mice slows the rate of atherosclerotic plaque formation.", "Formation of N-terminal pyroglutamate by glutamine cyclase (GC) competes with NTAQ1 for Nt-Gln substrates."], "hard_negative": "Microcin J25 encourages nucleoside triphosphate (NTP) binding."}
{"query_id": "788", "query_text": "Microcin J25 inhibits nucleoside triphosphate (NTP) binding.", "negative": "Smc5/6 engagment halts the activation of SUMO E3 ligase Mms21 by ATP-dependent remolding.", "negatives": ["Smc5/6 engagment halts the activation of SUMO E3 ligase Mms21 by ATP-dependent remolding.", "Human embryonic stem cells give rise to cell types from the outer embryonic germ layer, but not the other two layers.", "Activator-inhibitor pairs are provided ventrally by Xrl-sizzled.", "Adult tissue-resident macrophages are seeded before birth.", "Ribosome-inactivating protein-2 (RIP-2) interacts with the p75 NTR death domain", "Bariatric surgery leads to positive outcomes in mental health.", "Pioglitazone use is significantly associated with an increased risk of prostate cancer.", "90% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.", "Risk-adjusted mortality rates are similar in teaching and non-teaching hospitals.", "Foxp3 enables the expression of transcriptional regulators implicated in memory T cell development."], "hard_negatives": ["Microcin J25 inhibits nucleoside triphosphate (NTP) binding.", "Microcin J25 encourages nucleoside triphosphate (NTP) binding.", "Broadly HIV-1 Neutralizing Antibodies (bnAb) 10EB have no affinity for phospholipids.", "MUC1-C activates the NF-\u03baB p65 signaling pathway by interacting with I\u03baB kinase \u00df.", "Guanine nucleotide dissociation inhibitor (Rho-GDI) interacts with the p75 NTR death domain", "Lack of FGF21 in mice slows the rate of atherosclerotic plaque formation.", "Lack of FGF21 in mice leads to atherosclerotic plaque formation.", "p75 NTR - associated cell death executor (NADE) interacts with the p75 NTR death domain", "Formation of N-terminal pyroglutamate by glutamine cyclase (GC) competes with NTAQ1 for Nt-Gln substrates.", "mcm 5 s 2 U is required for proper decoding of NNR codons in eukaryotes."], "hard_negative": "Microcin J25 inhibits nucleoside triphosphate (NTP) binding."}
{"query_id": "789", "query_text": "Microglia are an innate immune cell type of the central nervous system.", "negative": "MafA phosphorylation decreases its ubiquitination.", "negatives": ["MafA phosphorylation decreases its ubiquitination.", "MICAL redox enzymes regulate actin dynamics in many cell types.", "A mutation in HNF4A leads to an increased risk of diabetes by the age of 14 years.", "IFIT1 speeds viral replication by allowing for the proliferation of mis-capped viral RNAs.", "Inhibiting glucose-6-phospate dehydrogenase improves lipogenesis by deactivating LKB1-AMPK signaling.", "53% of perinatal mortality is due to low birth weight.", "Albendazole is used to treat soil-transmitted helminths.", "The DdrB protein from Deinococcus radiodurans functions as a pentamer.", "Genes regulated by Esrrb transcription factor are sensitive to Mbd3 function.", "TNFAIP3 is a tumor enhancer in glioblastoma."], "hard_negatives": ["Microglia are an innate immune cell type of the central nervous system.", "Microglia are an innate immune cell type of the peripheral nervous system.", "Cancer-associated fibroblasts (CAFs) interact with cancer cells to mediate formation and activation of CAFs.", "Cancer-associated fibroblasts (CAFs) are constituents of tumor microenvironments", "Cancer-associated fibroblasts (CAFs) have no known interaction with cancer cells in the formation and activation of CAFs.", "Immune responses in immune cells are geographically segregated.", "Glioblastoma multiforme (GBM) is characterized by extensive invasion, rapid growth, necrosis, and angiogenesis.", "miRNAs regulate a unique suite of mRNAs to maintain homeostasis in cells.", "Tuberculosis-induced granulomas express different immune system protein signatures than the surrounding tissue.", "Dscam1 acts as a hypervariable pattern-recognition receptor for the immune system."], "hard_negative": "Microglia are an innate immune cell type of the central nervous system."}
{"query_id": "790", "query_text": "Microglia are an innate immune cell type of the peripheral nervous system.", "negative": "Moderate consumption of candy and chocolate reduces the risk of cardiovascular disease (CVD).", "negatives": ["Moderate consumption of candy and chocolate reduces the risk of cardiovascular disease (CVD).", "The tip of the inner tube of the toxic type VI secretion system (T6SS) antibacterial effector in Escherichia coli (E. coli) is decorated with VgrG and PAAR proteins.", "Increase of p62 in prostate tumor stroma results in defective autophagy.", "Ten percent (10%) of kidney cancers in the UK are attributable to excess weight.", "Commelina yellow mottle virus' (ComYMV) genome consists of 2140 baise pairs.", "HOXB4 facilitates HSC expansion when co-cultured with HSCs.", "Intake of folic acid (FA) and vitamin B6 (VB6) increases levels of homocysteine.", "MUC1-C activates the NF-\u03baB p65 signaling pathway by interacting with I\u03baB kinase \u00df.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have longer lifetime exposure to estrogen due to an increased reproductive period.", "Increased LDL receptors plays a role in the reduction of plasma Lp(a)."], "hard_negatives": ["Microglia are an innate immune cell type of the central nervous system.", "Microglia are an innate immune cell type of the peripheral nervous system.", "Cancer-associated fibroblasts (CAFs) are constituents of tumor microenvironments", "Cancer-associated fibroblasts (CAFs) interact with cancer cells to mediate formation and activation of CAFs.", "Cancer-associated fibroblasts (CAFs) have no known interaction with cancer cells in the formation and activation of CAFs.", "Immune responses in immune cells are geographically segregated.", "The innate immune response struggles to remove small numbers of parasites.", "miR-142-5P is a temperature-sensitive microRNA (miRNA).", "Lamins are found within the inner layer of the nuclear membrane of all cells.", "miRNAs regulate a unique suite of mRNAs to maintain homeostasis in cells."], "hard_negative": "Microglia are an innate immune cell type of the central nervous system."}
{"query_id": "791", "query_text": "Migraine with aura is associated with ischemic stroke.", "negative": "Ribosomopathies have a high degree of cell and tissue specific pathology.", "negatives": ["Ribosomopathies have a high degree of cell and tissue specific pathology.", "Sudden death can occur in patients with orthostatic hypertension without cardiac conduction abnormalities.", "Nonhuman primates are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.", "Excess gestational weight gain is associated with obesity-related pregnancy outcomes.", "Nigerian physicians constitue the largest component of sub-Saharan Africa-trained physicians in the United States.", "HOXB4 is a highly expressed component of cellular secretome from fetal liver cell populations.", "Upregulation of PD1 causes the upregulation of Satb1.", "1-1% of colorectal cancer patients are diagnosed with regional or distant metastases.", "Reduced phosphorylation of PP2A increases HDAC4 dephosphorylation by enhancing PP2A-HDAC4 interaction.", "Perigenital skin is not the primary site of HIV acquisition."], "hard_negatives": ["Migraine with aura is associated with ischemic stroke.", "Headaches are correlated with cognitive impairment.", "Antidepressants increase the severity of migraines.", "Antidepressants reduce the severity of migraines.", "Sudden death can occur in patients with complex ventricular arrhythmias.", "Sudden death can occur in patients with orthostatic hypertension without cardiac conduction abnormalities.", "Glial calcium waves influence seizures.", "Exposure to fine particulate air pollution is unrelated to anxiety prevalence.", "Decreased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm.", "Increased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm."], "hard_negative": "Migraine with aura is associated with ischemic stroke."}
{"query_id": "792", "query_text": "Misunderstandings between doctors and patients can lead to non-adherence.", "negative": "Cnn1 recruitment varies with cell cycle timing.", "negatives": ["Cnn1 recruitment varies with cell cycle timing.", "Type 1 Diabetes is associated with subtle perturbations in T reg development.", "Mutant mice lacking SVCT2 have severely reduced ascorbic acid levels in both brain and adrenals.", "The risk of female prisoners harming themselves is ten times that of male prisoners.", "In melanoma, anti-CTLA-4 treatment reinvigorates exhausted PD-1+Eomes+CD8 T cells.", "An M2-like phenotype in brown adipose tissue macrophages is quickly induced by cold exposure.", "Neutrophil extracellular trap (NET) antigens may contain the targeted autoantigens PR3 and MPO.", "Activation of the Rac1 homolog CED-10 kills viable cells in SRGP-1 mutant Caenorhabditis elegans.", "Most termination events in Okazaki fragments are dictated by initiation patterns.", "Adult tissue-resident macrophages stem from the embryonal yolk sac and fetal liver."], "hard_negatives": ["Misunderstandings between doctors and patients can lead to non-adherence.", "Assessing treatment adherence is more beneficial to clinical practice than measuring routine outcomes.", "Measuring routine outcomes is more beneficial to clinical practice than assessing treatment adherence.", "Students who perform poorly in the early years of medical school are at increased risk for professional misconduct later in their careers.", "Students who perform poorly in the early years of medical school are less likely to commit professional misconduct later in their careers.", "Including pharmacists in rounding teams reduces the incidence of adverse drug events (ADEs).", "Including pharmacists in rounding teams does not alter the incidence of adverse drug events (ADEs).", "Risk-adjusted mortality rates are similar in teaching and non-teaching hospitals.", "Integrated care is ineffective at tackling multiple comorbidities.", "Cost effectiveness evaluations based on cRCT data accurately reflect prices for patients in actual clinical practice."], "hard_negative": "Misunderstandings between doctors and patients can lead to non-adherence."}
{"query_id": "795", "query_text": "Mitochondria play a major role in apoptosis.", "negative": "Charcoal shows no benefit for acute paraquat poisoning.", "negatives": ["Charcoal shows no benefit for acute paraquat poisoning.", "Cost effectiveness evaluations based on cRCT data lack external validity.", "Cancers that initially benefit from epidermal growth factor receptor targeted therapies later become refractory through several mechanisms.", "Polymeal nutrition increases cardiovascular mortality.", "TRAP+ osteoclasts regulate mature osteoblast maintenance.", "HOXB4 facilitates HSC expansion when co-cultured with HSCs.", "One in two surgical randomized controlled trials are discontinued early.", "Pseudogene PTENP1 encodes a transcript that regulates PTEN expression.", "Trans-acting factors, such as lncRNAs, influence mRNA translation.", "British male students are bullied more than British female students."], "hard_negatives": ["Mitochondria play a major role in apoptosis.", "Mitochondria play a major role in energy production.", "Mitochondria play a trivial role in calcium homeostasis.", "Cytochrome c is transferred from cytosol to the mitochondrial intermembrane space during apoptosis.", "Oxidative phosphorylation is one of the primary glycometabolic pathways in cells.", "Cellular clocks are not predictive of mitosis timing in NIH 3T3 cells.", "Cellular clocks are associated with mitosis timing in NIH 3T3 cells.", "Cyclin A2 destruction is necessary to switch from unstable to stable kt-mt attachments in mitosis.", "Binding of p53 to enhancer regions (p53BERs) regulates the activity of p53 transcription and cell cycle arrest through the production of p53-dependent eRNAs.", "Forkhead 0 (fox0) transcription factors are involved in apoptosis."], "hard_negative": "Mitochondria play a major role in apoptosis."}
{"query_id": "797", "query_text": "Mitochondria play a major role in energy production.", "negative": "A mutation in HNF4A leads to an increased risk of diabetes by the age of 14 years.", "negatives": ["A mutation in HNF4A leads to an increased risk of diabetes by the age of 14 years.", "Patients with common epithelial cancers are less likely to have an emergency event as their first hospital admission if they live in resource-deprived areas.", "PKG-la plays an essential role in expression of spinal long term potentiation in PGK-la knockout mice.", "Patients with microcytosis and higher erythrocyte count were more resistant to severe malarial anaemia when infected with Plasmodium falciparum.", "Commelina yellow mottle virus (ComYMV) has three typical badnavirus ORFs, capable of encoding proteins 23, 15, and 216 kD.", "Clathrin stabilizes the spindle fiber apparatus during mitosis.", "L3MBTL2 binds to H2AK119Ub marked chromatin to form a PRC1 complex.", "Cancers that initially benefit from epidermal growth factor receptor targeted therapies later become refractory through several mechanisms.", "Venules have less significant tunica adventitia than arterioles.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have longer lifetime exposure to estrogen due to an increased reproductive period."], "hard_negatives": ["Mitochondria play a major role in energy production.", "Mitochondria play a major role in apoptosis.", "Mitochondria play a trivial role in calcium homeostasis.", "Oxidative phosphorylation is one of the primary glycometabolic pathways in cells.", "Cardiac tissue-resident macrophages directly contribute to electrical activity.", "The Snf1 complex regulates carbon and energy metabolism in baker's yeast (Saccharomyces cerevisiae).", "Cellular clocks are associated with mitosis timing in NIH 3T3 cells.", "Cellular clocks are not predictive of mitosis timing in NIH 3T3 cells.", "Nuclear transfer from adult human fibroblasts to human oocytes can give rise to blastocysts containing expandable pluripotent cells.", "Long - range chromatin interactions regulate transcription."], "hard_negative": "Mitochondria play a major role in energy production."}
{"query_id": "798", "query_text": "Mitochondria play a trivial role in calcium homeostasis.", "negative": "Long chain polyunsaturated fatty acids supplementation reduces wheezing and asthma.", "negatives": ["Long chain polyunsaturated fatty acids supplementation reduces wheezing and asthma.", "Induced hepatic stem cells possess the potential to differentiate into cholangiocytic cells.", "The peak incidence of fractures occurs in toddlers.", "H4 G94P proteins induce degradation of free histones via Rad53-dependent mechanisms.", "Pyridostatin prevents double-strand breaks accumulation.", "JMJD6 catalyzes the hydroxylation of C-terminal lysine and supresses transcriptional activity.", "Egr3 regulates the homeostasis of B and T cells.", "Therapeutics receiving accelerated approval encounter a lower frequency of post-marketing safety events", "Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection decreases dissemination of Salmonella Typhimurium from the gut.", "Genetic deletion of JAM-A increases gut permeability."], "hard_negatives": ["Mitochondria play a trivial role in calcium homeostasis.", "Mitochondria play a major role in energy production.", "Mitochondria play a major role in apoptosis.", "Cyclin A2 destruction is necessary to switch from unstable to stable kt-mt attachments in mitosis.", "Cellular clocks are not predictive of mitosis timing in NIH 3T3 cells.", "Cardiac tissue-resident macrophages directly contribute to electrical activity.", "Cellular clocks are associated with mitosis timing in NIH 3T3 cells.", "Oxidative phosphorylation is one of the primary glycometabolic pathways in cells.", "MICAL redox enzymes regulate actin dynamics in many cell types.", "Ca2+ cycling controls whole-body energy homeostasis in beige fat."], "hard_negative": "Mitochondria play a trivial role in calcium homeostasis."}
{"query_id": "799", "query_text": "Moderate consumption of candy and chocolate reduces the risk of cardiovascular disease (CVD).", "negative": "Immune complex triggered cell death leads to sequestration of oxidized mitochondrial DNA.", "negatives": ["Immune complex triggered cell death leads to sequestration of oxidized mitochondrial DNA.", "Patients with common epithelial cancers  are more likely to have an emergency event as their first hospital admission if they live in resource-deprived areas.", "Active caspase-11 participate in regulating phagosome-lysosome fusion.", "Aged patients are more susceptible to ischaemia/reperfusion injury.", "Expression of MSX2 is induced 3 hours after the addition of BMP4, which is earlier than T and CDX2.", "Incidence of heart failure increased by 10% in women since 1979.", "Commelina yellow mottle virus' (ComYMV) genome consists of 2140 baise pairs.", "Cost effectiveness evaluations based on cRCT data accurately reflect prices for patients in actual clinical practice.", "Mice lacking Sirt1 in Sf1-expressing neurons have increased susceptibility to diet-induced obesity and insulin resistance.", "Most termination events in Okazaki fragments are dictated by initiation patterns."], "hard_negatives": ["Moderate consumption of candy and chocolate reduces the risk of cardiovascular disease (CVD).", "It is not proven that moderate consumption of candy and chocolate reduces the risk of cardiovascular disease (CVD) specifically.", "Consumption of whole fruits increases the risk of type 2 diabetes.", "Taxation of sugar-sweetened beverages reduced the incidence rate of type II diabetes in India.", "Medications to treat obesity have unwanted side effects.", "LDL cholesterol has a causal role in the development of cardiovascular disease.", "Medications to treat obesity do not have side effects.", "In young and middle-aged adults, current or remote uses of ADHD medications increase the risk of serious cardiovascular events.", "Medications to treat obesity are highly effective.", "Autophagy deficiency in the liver increases vulnerability to insulin resistance."], "hard_negative": "Moderate consumption of candy and chocolate reduces the risk of cardiovascular disease (CVD)."}
{"query_id": "801", "query_text": "Monoclonal antibody targeting of N-cadherin encourages castration resistance.", "negative": "Reducing H3k4me3 methylation induces mouse epiblast stem cells to naive pluripotency efficiently.", "negatives": ["Reducing H3k4me3 methylation induces mouse epiblast stem cells to naive pluripotency efficiently.", "Ca2+ cycling is a UCP1-dependent thermogenic mechanism.", "Dscam1 acts as a hypervariable pattern-recognition receptor for the immune system.", "Tirasemtiv has no effect on cardiac muscle.", "Traditional reviews are biased in their interpretations.", "Fibroblast growth factor 21 protects against atherosclerosis by modulating adiponectin and SREBP2 levels.", "IgA plasma cells that are specific for transglutaminase 2 are scarce in the duodenal mucosa of celiac disease patients when the disease is active.", "Lack of FGF21 in mice increases life expectancy.", "Malaria has a high vectorial capacity.", "\u03b2-sheet opening occurs during pleurotolysin pore formation."], "hard_negatives": ["Monoclonal antibody targeting of N-cadherin encourages castration resistance.", "Monoclonal antibody targeting of N-cadherin inhibits castration resistance.", "Monoclonal antibody targeting of N-cadherin encourages metastasis.", "Monoclonal antibody targeting of N-cadherin inhibits growth.", "Sildenafil worsens erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.", "A breast cancer patient's capacity to metabolize tamoxifen influences treatment outcome.", "Nonsteroidal antinflammatory drugs are ineffective as cancer treatments.", "Nonsteroidal antinflammatory drugs show potential anticancer indications.", "Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission.", "Pioglitazone use is not associated with an increased risk of prostate cancer."], "hard_negative": "Monoclonal antibody targeting of N-cadherin encourages castration resistance."}
{"query_id": "802", "query_text": "Monoclonal antibody targeting of N-cadherin encourages metastasis.", "negative": "JMJD6 slows the hydroxylation of C-terminal lysine", "negatives": ["JMJD6 slows the hydroxylation of C-terminal lysine", "Origin gross domestic product(GDP) is negatively related to dengue virus (DENV-1) diffusion in air traffic shipments.", "RA activation of DIF2 and NB4 cells induces hallmarks of transcriptionally active promoters.", "Reduced phosphorylation of PP2A increases HDAC4 dephosphorylation by enhancing PP2A-HDAC4 interaction.", "Albendazole is used to treat soil-transmitted helminths.", "Specialized functional cell types can be derived from human pluripotent stem cells.", "Increased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm.", "Klf4 is important for proper myeloid cell differentiation.", "Transcription rates in S. cerevisiae range between 0.7 and 2 kb/min.", "Active caspase-11 participate in regulating phagosome-lysosome fusion."], "hard_negatives": ["Monoclonal antibody targeting of N-cadherin encourages metastasis.", "Monoclonal antibody targeting of N-cadherin inhibits growth.", "Monoclonal antibody targeting of N-cadherin inhibits castration resistance.", "Monoclonal antibody targeting of N-cadherin encourages castration resistance.", "A breast cancer patient's capacity to metabolize tamoxifen influences treatment outcome.", "Sildenafil worsens erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.", "Side effects associated with antidepressants increases risk of stroke.", "Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission.", "Nonsteroidal antinflammatory drugs show potential anticancer indications.", "The relationship between a breast cancer patient's capacity to metabolize tamoxifen and treatment outcome is independent of the patient's genetic make-up."], "hard_negative": "Monoclonal antibody targeting of N-cadherin encourages metastasis."}
{"query_id": "803", "query_text": "Monoclonal antibody targeting of N-cadherin inhibits castration resistance.", "negative": "Cancer-associated fibroblasts (CAFs) have no known interaction with cancer cells in the formation and activation of CAFs.", "negatives": ["Cancer-associated fibroblasts (CAFs) have no known interaction with cancer cells in the formation and activation of CAFs.", "HOXB4 facilitates HSC expansion when co-cultured with HSCs.", "There is no association between HNF4A mutations and diabetes risks.", "50% of patients exposed to radiation have activated markers of mesenchymal stem cells.", "Splenomegaly is observed in knockin mouse lacking the SHP-2 MAPK pathway.", "For every 1,000 children with cerebral palsy, more than 300 of them are premature or underweight at birth.", "Folate and vitamin B12 levels influence the association between homocysteine and preeclampsia.", "The NF-\u03baB essential modulator gene prevents intestinal inflammation by inhibiting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death.", "A T helper 2 cell (Th2) environment impedes disease development in patients with systemic lupus erythematosus (SLE).", "BLM gene encodes RecQ-class DNA helicase."], "hard_negatives": ["Monoclonal antibody targeting of N-cadherin inhibits castration resistance.", "Monoclonal antibody targeting of N-cadherin encourages castration resistance.", "Monoclonal antibody targeting of N-cadherin encourages metastasis.", "Monoclonal antibody targeting of N-cadherin inhibits growth.", "Sildenafil worsens erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.", "A breast cancer patient's capacity to metabolize tamoxifen influences treatment outcome.", "Nonsteroidal antinflammatory drugs are ineffective as cancer treatments.", "Nonsteroidal antinflammatory drugs show potential anticancer indications.", "Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission.", "Retinoic acid receptor-related orphan receptor gamma (ROR\u03b3) is a therapeutic target for castration-resistant prostate cancer (CRPC)"], "hard_negative": "Monoclonal antibody targeting of N-cadherin inhibits castration resistance."}
{"query_id": "804", "query_text": "Monoclonal antibody targeting of N-cadherin inhibits growth.", "negative": "Over half of the gabonese children with Schimmelpenning-Feuerstein-Mims syndrome (SFM) had a plasma lactate of more than 5mmol/L.", "negatives": ["Over half of the gabonese children with Schimmelpenning-Feuerstein-Mims syndrome (SFM) had a plasma lactate of more than 5mmol/L.", "MafA ubiquitination increases the recruitment of coavtivator P/CAF by MafA.", "Nonsteroidal antinflammatory drugs show potential anticancer indications.", "DUSP4 decreases apoptosis.", "RUNX is not expressed in skin tissue.", "Stacking is more stable when a purine is present in the +5 position (C1698).", "Early patent ductus ateriosus (PDA) screening increases in-hospital mortality.", "Ca2+ cycling is a UCP1-independent thermogenic mechanism.", "\u03b21/Ketel is able to bind microtubules.", "Genetic deficiency of mast cells leads to decreased weight gain in a mouse model of diet-induced obesity."], "hard_negatives": ["Monoclonal antibody targeting of N-cadherin inhibits growth.", "Monoclonal antibody targeting of N-cadherin encourages metastasis.", "Monoclonal antibody targeting of N-cadherin inhibits castration resistance.", "Monoclonal antibody targeting of N-cadherin encourages castration resistance.", "Nonsteroidal antinflammatory drugs show potential anticancer indications.", "Upon developing tyrosine-kinase inhibitor resistance, new mutations in epidermal growth factor receptors emerge and cause treatment failure.", "Nonsteroidal antinflammatory drugs are ineffective as cancer treatments.", "N348I mutations reduce resistance to nevirapine.", "A breast cancer patient's capacity to metabolize tamoxifen influences treatment outcome.", "Sildenafil worsens erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants."], "hard_negative": "Monoclonal antibody targeting of N-cadherin inhibits growth."}
{"query_id": "807", "query_text": "Most termination events in Okazaki fragments are dictated by initiation patterns.", "negative": "Antimicrobial agents are less effective due to the pressure of antimicrobial usage.", "negatives": ["Antimicrobial agents are less effective due to the pressure of antimicrobial usage.", "Glial calcium waves influence seizures.", "Surgical treatment is not superior to non-surgical in treating adults with displaced fractures of the proximal humerus.", "A mutation in HNF4A leads to an increased risk of developing diabetes by the age of 14 years.", "DUSP4 decreases apoptosis.", "The recruitment of Wdr5 to its target loci depends on Kat8.", "G-CSF increases the expansion and infiltration of MDSCs into tumors.", "Ultrasound guidance significantly reduces the number of needle insertion attempts necessary for a given procedure.", "The density of cytokine receptor bearing cells affects the distance over which cytokines act.", "In breast cancer, the loss of myoepithelial cells promotes the transition of ductal carcinoma in situ to invasive carcinoma."], "hard_negatives": ["Most termination events in Okazaki fragments are dictated by initiation patterns.", "Alteration of origin firing causes changes in termination zones of Okazaki fragments.", "Recognition of start codons depends on the translation initiation factor IF3.", "Understanding epigenetic regulation of replication is essential for the reational design of episomally replicating vectors.", "Pseudoknots are not evolutionarily conserved in most eukaryotes.", "The number of unfertilized oocytes in mated hermaphrodites increases with age.", "mcm 5 s 2 U is required for proper decoding of NNR codons in eukaryotes.", "During non-homologous end joining, the ligation step is not as tolerant of disrepairs and other distortions when joining 5' of strand breaks as compared to 3' strand breaks.", "During non-homologous end joining, the ligation step is not as tolerant of disrepairs and other distortions when joining 3' of strand breaks as compared to 5' strand breaks.", "Cellular differentiation of embryonic stem cells is accompanied by changes in replication timing, transcription and nuclear localization."], "hard_negative": "Most termination events in Okazaki fragments are dictated by initiation patterns."}
{"query_id": "810", "query_text": "Mouse models can be generated using \"artificial spermatids.\"", "negative": "The repeat-variable diresidue (RVD) in the loop of Transcription-Activator Like (TAL) effectors specifies the nucleotides-amino acid contact at the target promoter element.", "negatives": ["The repeat-variable diresidue (RVD) in the loop of Transcription-Activator Like (TAL) effectors specifies the nucleotides-amino acid contact at the target promoter element.", "Homozygous deletion of murine Sbds gene from osterix-expressing mesenchymal stem and progenitor cells (MPCs) induces oxidative stress.", "Oxidative DNA damage inhibits STING signalling.", "Type 1 Diabetes is associated with subtle perturbations in T reg development.", "Glycan adaptation is rarely observed in the B-cell repertoire.", "There is a positive correlation between hip fractures and statin use.", "Most termination events in Okazaki fragments are dictated by initiation patterns.", "Natriuretic peptides protect against diabetes.", "The predominant localization of Linc00173 is in mononuclear macrophage nuclei.", "Lack of FGF21 in mice increases life expectancy."], "hard_negatives": ["Mouse models can be generated using \"artificial spermatids.\"", "Androgenetic haploid mouse embryonic stem cells (ESCs) can be derived and genetically manipulated in vitro.", "In pediatric tissue, most T cells are naive T cell emigrants from the thymus.", "Human embryonic stem cells have the capacity to give rise to differentiated progeny representative of all three embryonic germ layers.", "Specialized functional cell types can be derived from human pluripotent stem cells.", "Transplanted human glial progenitor cells can mature in their host animal.", "Human embryonic stem cells give rise to cell types from all three embryonic germ layers.", "Human embryonic stem cells give rise to cell types from the outer embryonic germ layer, but not the other two layers.", "The number of unfertilized oocytes in mated hermaphrodites increases with age.", "De novo assembly of sequence data has fewer specific contigs than unassembled sequence data."], "hard_negative": "Mouse models can be generated using \"artificial spermatids.\""}
{"query_id": "812", "query_text": "Mutant mice lacking SVCT2 have severely reduced ascorbic acid levels in both brain and adrenals.", "negative": "The PPR MDA5 has twenty N-terminal CARD domains.", "negatives": ["The PPR MDA5 has twenty N-terminal CARD domains.", "Reducing H3k4me3 methylation induces mouse epiblast stem cells to naive pluripotency efficiently.", "Major vault protein (MVP) leads to more aggressive tumors by regulating the sorting of tumor suppressive miR-193a into extracellular vesicles (EVs).", "Citrullinated proteins externalized in neutrophil extracellular traps act indirectly to disrupt the inflammatory cycle.", "Primary pro-inflammatory cytokines suppress secondary pro- and anti-inflammatory mediators.", "FACT and other histone chaperone(s) compensate for Histone 2A (H2A)-histone 2B (H2B) dimer eviction during the histone exchange process.", "Tonic signaling from the scFv prevents constitutive stimulation.", "The DdrB protein from Deinococcus radiodurans functions as a pentamer.", "The number of unfertilized oocytes in mated hermaphrodites increases with age.", "A 100g dose of chloroquine chemoprophylactic regimen results in retinal toxicity after 5-6 years of weekly intake."], "hard_negatives": ["Mutant mice lacking SVCT2 have severely reduced ascorbic acid levels in both brain and adrenals.", "Mice lacking Sirt1 in Sf1-expressing neurons have increased susceptibility to diet-induced obesity and insulin resistance.", "Mice lacking Sirt1 in Sf1-expressing neurons are immune to diet-induced obesity and insulin resistance.", "Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes fibrosis.", "A deficiency of vitamin B12 decreases blood levels of homocysteine.", "A deficiency of folate increases blood levels of homocysteine.", "Lack of FGF21 in mice slows the rate of atherosclerotic plaque formation.", "Reduced levels of lipolysis leads to higher P38 phosphorylation in adipose tissue.", "Lack of FGF21 in mice leads to atherosclerotic plaque formation.", "A deficiency of vitamin B6 decreases blood levels of homocysteine."], "hard_negative": "Mutant mice lacking SVCT2 have severely reduced ascorbic acid levels in both brain and adrenals."}
{"query_id": "813", "query_text": "Mutations in G-Beta protein GNB1 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.", "negative": "The M2-phenotype in brown adipose tissue macrophages increases brown adipose tissue thermogenic activity.", "negatives": ["The M2-phenotype in brown adipose tissue macrophages increases brown adipose tissue thermogenic activity.", "Transcription factor EB induces transcription of pro-inflammatory cytokines in macrophages infected with Staphylococcus aureus.", "TNFAIP3 is a glioblastoma tumor suppressor.", "Piezo1 channels are sensors for cell migration in epithelial cells.", "Gastric infection with Helicobacter pylori decreases risk of gastric cancer in humans.", "A mutation in HNF4A leads to an increased risk of diabetes by the age of 14 years.", "Peroxynitrite is required for induction of T cell tolerance.", "MeCP2 influences the synaptic maturation of neurons.", "Hematopoietic Stem Cell purification reaches purity rates above 90%.", "Intra-cerebroventricular infusion of amyloid-\u03b2 oligomers reduces expression of fibronectin type-III domain-containing protein 5 mRNA in mice hippocampi."], "hard_negatives": ["Mutations in G-Beta protein GNB1 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.", "ScPif1p has reduced binding ability to G-rich ssDNA compared to non-G-rich ssDNA.", "The deamination of cytidine to uridine on the minus strand of viral DNA can inactivate the viral genome by inducing G-to-A mutations.", "A deficiency of vitamin B12 decreases blood levels of homocysteine.", "ScPif1p has higher binding ability to G-rich ssDNA than to non-G-rich ssDNA.", "The minor G allele of FOXO3 downregulates pro-inflammatory cytokines.", "The minor G allele of FOXO3 is related to less severe symptoms of Crohn's Disease.", "MUC1-C activates the NF-\u03baB p65 signaling pathway by interacting with I\u03baB kinase \u00df.", "In patients with congenital heart defects, \u03b2-blockers significantly improve clinical heart failure outcomes.", "Glioblastoma multiforme (GBM) is characterized by extensive invasion, rapid growth, necrosis, and angiogenesis."], "hard_negative": "Mutations in G-Beta protein GNB1 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway."}
{"query_id": "815", "query_text": "Mutations in RIM1 decrease levels of IME1 RNA.", "negative": "p75 NTR - associated cell death executor (NADE) interacts with the p75 NTR death domain", "negatives": ["p75 NTR - associated cell death executor (NADE) interacts with the p75 NTR death domain", "Replacement of OCT4 and SOX2 genes with GATA3 has the ability to reprogram human cells.", "The tip of the inner tube of the toxic type VI secretion system (T6SS) antibacterial effector in Escherichia coli (E. coli) is decorated with VgrG and PAAR proteins.", "Pioglitazone use is significantly associated with an increased risk of pancreatic cancer.", "Bone marrow cells don't contribute to adult macrophage compartments.", "In rhesus macaques, daily subcutaneous injections of tenofovir protects against rectally transmitted simian-human immunodeficiency virus.", "miR-142-5P is a temperature-sensitive microRNA (miRNA).", "Osteocytes have an essential role in G-CSF induced HSPC mobilization.", "Patients with microcytosis and higher erythrocyte count were more resistant to severe malarial anaemia when infected with Plasmodium falciparum.", "HSCT-T dosage may not be diagnostic if the onset of symptoms occurs less than 3 hours before AMI."], "hard_negatives": ["Mutations in RIM1 decrease levels of IME1 RNA.", "Mutations in RIM1 raise levels of IME1 RNA.", "The PPR MDA5 has twenty N-terminal CARD domains.", "IFIT1 speeds viral replication by allowing for the proliferation of mis-capped viral RNAs.", "LSD1-positive promoters are associated with RNA polymerase II", "p16INK4A degradation is  linked to an abnormal wound response caused by the microinvasive step of advanced Oral Potentially Malignant Lesions (OPMLs).", "RAD52 is involved in break-induced DNA replication (BIR).", "Emodin forms hydrogen bonds with residues involved in PGAM1 substrate binding.", "mcm 5 s 2 U is required for proper decoding of NNR codons in eukaryotes.", "MafA phosphorylation enhances its ubiquitination."], "hard_negative": "Mutations in RIM1 decrease levels of IME1 RNA."}
{"query_id": "816", "query_text": "Mutations in RIM1 raise levels of IME1 RNA.", "negative": "Retinoic acid receptor-related orphan receptor gamma (ROR\u03b3) is a therapeutic target for castration-resistant prostate cancer (CRPC)", "negatives": ["Retinoic acid receptor-related orphan receptor gamma (ROR\u03b3) is a therapeutic target for castration-resistant prostate cancer (CRPC)", "Gastric infection with Helicobacter pylori increases risk of gastric cancer in humans.", "Malaria has a high vectorial capacity.", "Medications to treat obesity are highly effective.", "Foxp3 represses the expression of transcriptional regulators implicated in memory T cell development.", "LDL cholesterol has a causal role in the development of cardiovascular disease.", "Microcin J25 inhibits nucleoside triphosphate (NTP) binding.", "Pro-inflammatory cytokines are up repressed during tumor development.", "Ca2+ cycling is a UCP1-dependent thermogenic mechanism.", "Reducing H3k4me3 methylation induces mouse epiblast stem cells to naive pluripotency efficiently."], "hard_negatives": ["Mutations in RIM1 decrease levels of IME1 RNA.", "Mutations in RIM1 raise levels of IME1 RNA.", "IFIT1 speeds viral replication by allowing for the proliferation of mis-capped viral RNAs.", "The PPR MDA5 has twenty N-terminal CARD domains.", "LSD1-positive promoters are associated with RNA polymerase II", "RAD52 is involved in break-induced DNA replication (BIR).", "p16INK4A degradation is  linked to an abnormal wound response caused by the microinvasive step of advanced Oral Potentially Malignant Lesions (OPMLs).", "MafA phosphorylation enhances its ubiquitination.", "Emodin forms hydrogen bonds with residues involved in PGAM1 substrate binding.", "mcm 5 s 2 U is required for proper decoding of NNR codons in eukaryotes."], "hard_negative": "Mutations in RIM1 decrease levels of IME1 RNA."}
{"query_id": "817", "query_text": "Myelin sheaths are lipid-rich cellular structures.", "negative": "Genes involved in pre-mRNA splicing have a significant impact on genome stability.", "negatives": ["Genes involved in pre-mRNA splicing have a significant impact on genome stability.", "T cell receptor /CD3 microdomains are required to induce the immunologic synapse.", "Oat tolerant coeliac patients may have oat specific inflammatory cells in their small bowel mucosa.", "\u03b21/Ketel is able to bind microtubules.", "Trans-acting factors, such as lncRNAs, influence mRNA translation.", "Splenomegaly is observed in knockin mouse lacking the SHP-2 MAPK pathway.", "The one-child policy has created a hospitable environment for female infants.", "There is no known interaction between Pioneer factor OCT3/4 and major chromatin remodeling factors.", "Rhythmic expression of Cry1 translates directly into a circadian regulation of cAMP signaling in gluconeogenesis.", "MICAL redox enzymes regulate actin dynamics."], "hard_negatives": ["Myelin sheaths are lipid-rich cellular structures.", "Myelin sheaths play a role in action potential propagation.", "Lamins are found within the inner layer of the nuclear membrane of all cells.", "Lamins are found within the inner layer of the mitochondrial membrane of all cells.", "Lamins are associated with nuclear membrane structure maintenance.", "Lamins have no effect on nuclear membrane structure maintenance.", "Cancer-associated fibroblasts (CAFs) are constituents of tumor microenvironments", "Cancer-associated fibroblasts (CAFs) interact with cancer cells to mediate formation and activation of CAFs.", "The microtubule-dependent delivery and secretion of matrix metalloproteases (MMPs) is partially responsible for the disassembly of adhesion sites.", "0-dimensional biomaterials lack inductive properties."], "hard_negative": "Myelin sheaths are lipid-rich cellular structures."}
{"query_id": "818", "query_text": "Myelin sheaths play a role in action potential propagation.", "negative": "aPKCz causes tumour suppression by affecting glutamine metabolism.", "negatives": ["aPKCz causes tumour suppression by affecting glutamine metabolism.", "Reduction of purity of cytoplasmic membranes isolated from overexpressors is indicated by stronger spots for OmpA in 2D BN-PAGE gels.", "Cytochrome c is transferred from cytosol to the mitochondrial intermembrane space during apoptosis.", "Increased mobility of retrotransposons does not lead to mutation and higher tumorigenesis rates.", "CDK6 shows impaired binding to loss-of-function variants of p18 INK4C.", "Sympathetic nerve activity is elevated throughout normal pregnancy.", "The proportion of people with visual difficulty is two times higher in low-income countries than in high-income countries.", "The DEXI promoter region is bound by multiple transcription factors in a murine haematopoietic progenitor cell line.", "Understanding epigenetic regulation of replication is essential for the reational design of episomally replicating vectors.", "Certain immunomodulator-human dialyzable leukocyte extract (hDLE) peptides are recognized by toll-like receptors (TLRs) on macrophages and dendritic cells."], "hard_negatives": ["Myelin sheaths play a role in action potential propagation.", "Myelin sheaths are lipid-rich cellular structures.", "Lamins are associated with nuclear membrane structure maintenance.", "Inhibiting focal adhesion formation enables cells to convert mechanical strain into eventual scarring.", "Binding of p53 to enhancer regions (p53BERs) regulates the activity of p53 transcription and cell cycle arrest through the production of p53-dependent eRNAs.", "Inhibiting focal adhesion formation increases the rate at which cells convert mechanical strain into inflammation and fibrosis.", "Cancer-associated fibroblasts (CAFs) interact with cancer cells to mediate formation and activation of CAFs.", "Lamins have no effect on nuclear membrane structure maintenance.", "Lamins are found within the inner layer of the nuclear membrane of all cells.", "EGR2 is important to myelination of the peripheral nervous system."], "hard_negative": "Myelin sheaths play a role in action potential propagation."}
{"query_id": "822", "query_text": "N348I mutations cause resistance to nevirapine.", "negative": "GATA3 regulates self-renewal capacity in bone marrow hematopoietic stem cells.", "negatives": ["GATA3 regulates self-renewal capacity in bone marrow hematopoietic stem cells.", "The deregulated and prolonged activation of monocytes has deleterious effects in chronic infectious conditions.", "The myocardial cell lineage originally develops from cardiac progenitors of exclusively endodermal origin.", "Albendazole is used to treat soil-transmitted helminths.", "Epidemiological disease burden from noncommunicable diseases is more prevalent in high economic settings.", "miRNAs enforce homeostasis by suppressing low-level ''leaky'' transcription.", "Microcin J25 inhibits nucleoside triphosphate (NTP) binding.", "Algerian physicians constitue the largest component of sub-Saharan Africa-trained physicians in the United States.", "5'-nucleotidase metabolizes 6MP.", "High levels of CRP lead to a higher risk of exacerbations in chronic obstructive pulmonary disease (COPD)."], "hard_negatives": ["N348I mutations cause resistance to nevirapine.", "N348I mutations reduce resistance to nevirapine.", "Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission.", "R2D2 stops miRNA production by increasing the selectivity of Dcr2 for long dsRNA.", "The deamination of cytidine to uridine on the minus strand of viral DNA can inactivate the viral genome by inducing G-to-A mutations.", "Carriers of HNF4A mutations are at reduced risk for diabetes.", "HNF4A mutations are associated with macrosomia in infancy.", "Monoclonal antibody targeting of N-cadherin encourages metastasis.", "There is no association between HNF4A mutations and diabetes risks.", "The PPR MDA5 has twenty N-terminal CARD domains."], "hard_negative": "N348I mutations cause resistance to nevirapine."}
{"query_id": "825", "query_text": "N348I mutations reduce resistance to nevirapine.", "negative": "In breast cancer, the loss of myoepithelial cells slows the transition of ductal carcinoma in situ to invasive carcinoma.", "negatives": ["In breast cancer, the loss of myoepithelial cells slows the transition of ductal carcinoma in situ to invasive carcinoma.", "Pyridostatin stabilizes the G - quadruplex in the telomeric region.", "RA activation of DIF2 and NB4 cells induces hallmarks of transcriptionally active promoters.", "Human embryonic stem cells have the capacity to give rise to differentiated progeny representative of all three embryonic germ layers.", "De novo assembly of sequence data has fewer specific contigs than unassembled sequence data.", "Transcription factor EB induces transcription of pro-inflammatory cytokines in macrophages infected with Staphylococcus aureus.", "PrimPol generates short DNA replication intermediates on the leading strand during DNA replication.", "Diabetes remission occurs more in people treated with conventional therapy than in people treated with laparoscopic adjustable gastric banding surgery.", "cSMAC formation represses weak ligand signalling.", "Origin gross domestic product(GDP) is positively related to dengue virus (DENV-1) diffusion in air traffic shipments."], "hard_negatives": ["N348I mutations reduce resistance to nevirapine.", "N348I mutations cause resistance to nevirapine.", "Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission.", "R2D2 stops miRNA production by increasing the selectivity of Dcr2 for long dsRNA.", "Monoclonal antibody targeting of N-cadherin encourages metastasis.", "The deamination of cytidine to uridine on the minus strand of viral DNA can inactivate the viral genome by inducing G-to-A mutations.", "Carriers of HNF4A mutations are at reduced risk for diabetes.", "There is no association between HNF4A mutations and diabetes risks.", "Monoclonal antibody targeting of N-cadherin inhibits growth.", "HNF4A mutations are associated with macrosomia in infancy."], "hard_negative": "N348I mutations reduce resistance to nevirapine."}
{"query_id": "826", "query_text": "NAC destabilizes NO to increase the effect of contrast agents on renal functions.", "negative": "The DESMOND program demonstrates no significant impact on biochemical outcomes.", "negatives": ["The DESMOND program demonstrates no significant impact on biochemical outcomes.", "The minor G allele of FOXO3 downregulates pro-inflammatory cytokines.", "Genes regulated by Esrrb transcription factor are sensitive to Mbd3 function.", "The innate immune response struggles to remove small numbers of parasites.", "Microglia are an innate immune cell type of the peripheral nervous system.", "Lack of FGF21 in mice slows the rate of atherosclerotic plaque formation.", "The peak incidence of fractures occurs in toddlers.", "Persister cells provide relapse resistance in cancer patients.", "High levels of CRP lead to a higher risk of exacerbations in chronic obstructive pulmonary disease (COPD).", "Citrullinated proteins externalized in neutrophil extracellular traps act indirectly to perpetuate the inflammatory cycle via induction of autoantibodies."], "hard_negatives": ["NAC destabilizes NO to increase the effect of contrast agents on renal functions.", "Angiotensin converting enzyme inhibitors are associated with decreased risk for functional renal insufficiency.", "The effect of Lipopolysaccharides on kidney barrier function is dependent on inflammation levels.", "NAC inhibits the generation of angiotensin-converting enzyme.", "Lipopolysaccharides have an inflammation independent effect on kidney barrier function.", "40mg/day dosage of folic acid and 2mg/day dosage of vitamin B12 does not affect chronic kidney disease (CKD) progression.", "Reduced phosphorylation of PP2A increases HDAC4 dephosphorylation by enhancing PP2A-HDAC4 interaction.", "Reduced phosphorylation of PP2A suppresses HDAC4 dephosphorylation.", "Systemic immunosuppressive (IS) therapy does not enhance the chance of cancer mortality in patients with inflammatory eye disease (IED)", "32% of liver transplantation programs required patients to discontinue methadone treatment in 2001."], "hard_negative": "NAC destabilizes NO to increase the effect of contrast agents on renal functions."}
{"query_id": "828", "query_text": "NAC inhibits the generation of angiotensin-converting enzyme.", "negative": "Lipopolysaccharides have an inflammation independent effect on kidney barrier function.", "negatives": ["Lipopolysaccharides have an inflammation independent effect on kidney barrier function.", "Propriospinal interneurons that play a role in the plastic reorganization of spinal circuits are integral for recovery from spinal cord injury.", "Forkhead 0 (fox0) transcription factors are involved in apoptosis.", "DRD1 proteins enable Pol V transcription in vivo.", "Replacement of OCT4 and SOX2 genes with GATA3 has the ability to reprogram human cells.", "Localization of PIN1 in the roots of Arabidopsis requires VPS9a", "Mice lacking Sirt1 in Sf1-expressing neurons have increased susceptibility to diet-induced obesity and insulin resistance.", "A low percentage of hematopoietic progenitor cells are susceptible to HIV-1 infection ex vivo.", "Antimicrobial agents are less effective due to the pressure of antimicrobial usage.", "CCL19 is a ligand for CCR7."], "hard_negatives": ["NAC inhibits the generation of angiotensin-converting enzyme.", "Angiotensin converting enzyme inhibitors are associated with decreased risk for functional renal insufficiency.", "NAC destabilizes NO to increase the effect of contrast agents on renal functions.", "Side effects associated with antidepressants lower risk of myocardial infarction.", "AMP-activated protein kinase (AMPK) activation reduces inflammation-related fibrosis in the lungs.", "Depletion of nitric oxide is responsible for vasospasm.", "The cytokine receptor which regulates chemotaxis and formation of lymph nodes is involved in production of myeloperoxidase in the left atrium.", "Inhibiting glucose-6-phospate dehydrogenase improves lipogenesis by deactivating LKB1-AMPK signaling.", "Monoclonal antibody targeting of N-cadherin inhibits growth.", "Chenodeoxycholic acid treatment increases brown adipose tissue activity."], "hard_negative": "NAC inhibits the generation of angiotensin-converting enzyme."}
{"query_id": "835", "query_text": "NR5A2 does not play a role in development of endometrial tissues.", "negative": "Bariatric surgery leads to positive outcomes in mental health.", "negatives": ["Bariatric surgery leads to positive outcomes in mental health.", "Foxk2 regulates autophagy genes in muscle cells and fibroblast cells.", "PGE 2 suppresss intestinal tumor growth by altering the expression of tumor suppressing and DNA repair genes.", "Environmental factors can influence the development of breast cancer.", "Intra-cerebroventricular infusion of amyloid-\u03b2 oligomers reduces expression of fibronectin type-III domain-containing protein 5 mRNA in mice hippocampi.", "Incidence of 10/66 dementia is lower than the incidence of DSM-IV dementia.", "Normal expression of RUNX1 causes tumorsupressing effects.", "siRNA knockdown of A20 accelerates tumor progression in an in vivo murine xenograft model.", "RANK-RANKL pathway signalling is linked to development of Aire-expressing medullary thymic epithelial cells.", "Decreased conversion of PGE 2 to PPARy ligand 15-ket-PGE 2 causes accumulation of PGE."], "hard_negatives": ["NR5A2 does not play a role in development of endometrial tissues.", "NR5A2 is important in reverse cholesterol transport in humans.", "EGR2 is important to myelination of the peripheral nervous system.", "HAND2 methylation is a key step in early endometrial carcinogenesis.", "Deregulation of HAND2 is a crucial step in endometrial carcinogenesis in mice.", "Activated Cdk5 regulates DNA damage-induced neuronal death.", "ALDH1 expression is associated with poorer prognosis for breast cancer primary tumors.", "p16INK4A degradation is encoded by CDKN2A.", "eRNAs influence is linked to senescence, aging, and carcinogenesis.", "Activation of PPM1D enhances p53 function."], "hard_negative": "NR5A2 does not play a role in development of endometrial tissues."}
{"query_id": "838", "query_text": "NR5A2 is important in reverse cholesterol transport in humans.", "negative": "Dscam1 acts as a hypervariable pattern-recognition receptor for the immune system.", "negatives": ["Dscam1 acts as a hypervariable pattern-recognition receptor for the immune system.", "Bariatric surgery leads to negative outcomes in mental health.", "AMP-activated protein kinase (AMPK) activation reduces inflammation-related fibrosis in the lungs.", "Noninvasive positive pressure ventilation is not predictive of acute respiratory failure after solid organ transplantation.", "Reduced responsiveness to interleukin-2 in regulatory T cells is associated with autoimmune diseases such as Type 1 Diabetes.", "Hematopoietic Stem Cell purification reaches purity rates above 90%.", "Intra-cerebroventricular infusion of amyloid-\u03b2 oligomers reduces expression of fibronectin type-III domain-containing protein 5 mRNA in mice hippocampi.", "Risedronate increases risk of vertebral and non-vertebral fractures.", "Walking in traffic areas in London improves lung function in elderly adults.", "The Snf1 complex regulates carbon and energy metabolism in baker's yeast (Saccharomyces cerevisiae)."], "hard_negatives": ["NR5A2 is important in reverse cholesterol transport in humans.", "NR5A2 does not play a role in development of endometrial tissues.", "p16INK4A degradation is encoded by CDKN2A.", "EGR2 is important to myelination of the peripheral nervous system.", "LDL cholesterol has a causal role in the development of cardiovascular disease.", "Increased lipolysis leads to higher P38 phosphorylation in adipose tissue.", "Reduced levels of lipolysis leads to higher P38 phosphorylation in adipose tissue.", "GATA3 regulates self-renewal capacity in bone marrow hematopoietic stem cells.", "GATA3 regulates cell cycle progression in bone marrow hematopoietic stem cells.", "Activated Cdk5 phosphorylates the ATM protein in response to DNA damage."], "hard_negative": "NR5A2 is important in reverse cholesterol transport in humans."}
{"query_id": "840", "query_text": "Natriuretic peptides increase susceptibility to diabetes.", "negative": "B3-Galectin decreases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR.", "negatives": ["B3-Galectin decreases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR.", "90% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.", "Lamins are associated with nuclear membrane structure maintenance.", "Cellular differentiation of embryonic stem cells is accompanied by changes in replication timing, transcription and nuclear localization.", "MFGE8 regulates fat absorption by binding to av-Beta3 and av-Beta5 integrins.", "Cancer-associated fibroblasts (CAFs) interact with cancer cells to mediate formation and activation of CAFs.", "Gastric lavage is an effective treatment for acute paraquat poisoning.", "Decrease of p62 in prostate tumor stroma results in defective autophagy.", "Active caspase-11 participate in regulating phagosome-lysosome fusion.", "Human embryonic stem cells give rise to cell types from all three embryonic germ layers."], "hard_negatives": ["Natriuretic peptides increase susceptibility to diabetes.", "Natriuretic peptides protect against diabetes.", "Medications to treat obesity have unwanted side effects.", "Long chain polyunsaturated fatty acids supplementation reduces wheezing and asthma.", "Type 1 Diabetes is associated with subtle perturbations in T reg development.", "Omnivores produce less trimethylamine N-oxide from dietary I-carnitine than vegans.", "Medications to treat obesity do not have side effects.", "Medications to treat obesity are highly effective.", "Omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegans.", "Autophagy deficiency in the liver increases vulnerability to insulin resistance."], "hard_negative": "Natriuretic peptides increase susceptibility to diabetes."}
{"query_id": "841", "query_text": "Natriuretic peptides protect against diabetes.", "negative": "Taxation of sugar-sweetened beverages reduced the incidence rate of type II diabetes in India.", "negatives": ["Taxation of sugar-sweetened beverages reduced the incidence rate of type II diabetes in India.", "The RANK-RANK-Ligand (RANKL) pathway is involved in the development of Aire-expressing medullary thymic epithelial cells (mTECs).", "Lysine histone demethylase inhibitor JIB 04 is inactive against KDM5A.", "Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 inhibit West Nile virus replication in cortical neurons.", "Approximately 250,000 people are infected with human T-cell lymphotropic virus type 1 in the United Kingdom.", "Improvements in OER catalysts show stable activity over several hundred hours.", "Lysine histone demethylase inhibitor JIB 04 is inactive against KDM5A.", "Intra-cerebroventricular infusion of amyloid-\u03b2 oligomers reduces expression of fibronectin type-III domain-containing protein 5 mRNA in mice hippocampi.", "BiP is a general endoplasmic reticulum stress marker.", "Deltex interacts with eIF3. There is no known interaction between Deltex and elF3"], "hard_negatives": ["Natriuretic peptides protect against diabetes.", "Natriuretic peptides increase susceptibility to diabetes.", "Long chain polyunsaturated fatty acids supplementation reduces wheezing and asthma.", "Long chain polyunsaturated fatty acids supplementation has no significant effects on wheezing or asthma at 3 and 6 years.", "Type 1 Diabetes is associated with subtle perturbations in T reg development.", "Medications to treat obesity have unwanted side effects.", "Medications to treat obesity are highly effective.", "Peroxynitrite is required for induction of T cell tolerance.", "Prescribed exercise training improves quality of life.", "Diabetes remission occurs more in people treated with conventional therapy than in people treated with laparoscopic adjustable gastric banding surgery."], "hard_negative": "Natriuretic peptides protect against diabetes."}
{"query_id": "844", "query_text": "Neutrophil extracellular trap (NET) antigens may contain the targeted autoantigens PR3 and MPO.", "negative": "RANK-RANKL pathway signalling is linked to development of Aire-expressing medullary thymic epithelial cells.", "negatives": ["RANK-RANKL pathway signalling is linked to development of Aire-expressing medullary thymic epithelial cells.", "p16INK4A degradation is  linked to an abnormal wound response caused by the microinvasive step of advanced Oral Potentially Malignant Lesions (OPMLs).", "Vitamin D deficiency effects birth weight.", "T cell receptor /CD3 microdomains are required to induce the immunologic synapse.", "Upon viral challenge, influenza-specific memory CD4+ T cells greatly enhance the early production of inflammatory chemokines in the lung.", "Incidence of 10/66 dementia is lower than the incidence of DSM-IV dementia.", "Taking anti-depresents is associated with a decrease in the A\u03b2 level in the brain of experimental animals.", "Physical activity does not improve cognitive function in individuals with Alzheimers.", "A diminished ovarian reserve is a very strong indicator of infertility, even in an a priori non-infertile population.", "Gpr124 increases BBB breakdown in mouse models of ischemic stroke."], "hard_negatives": ["Neutrophil extracellular trap (NET) antigens may contain the targeted autoantigens PR3 and MPO.", "Many transmembrane receptors transmit signals by long-range conformational changes in the association of alpha-helices across the plasma membrane.", "VgrG (Tssl) protein punctures membranes by forming a spike at the tip of the tube apparatus.", "Citrullinated proteins externalized in neutrophil extracellular traps act indirectly to disrupt the inflammatory cycle.", "Neutrophils produce IL-1\u03b2 in response to large particles.", "Citrullinated proteins externalized in neutrophil extracellular traps act indirectly to perpetuate the inflammatory cycle via induction of autoantibodies.", "Ly49Q directs the organization of neutrophil polarization by regulating membrane raft functions.", "Intramembrane cleavage by signal peptide peptidase aids in the degradation of proteins with a complex membrane orientation.", "The microtubule-dependent delivery and secretion of matrix metalloproteases (MMPs) is partially responsible for the disassembly of adhesion sites.", "Major antigen-induced signals from the T cell receptor and secondary signals from costimulatory receptors are required for T cell activation."], "hard_negative": "Neutrophil extracellular trap (NET) antigens may contain the targeted autoantigens PR3 and MPO."}
{"query_id": "846", "query_text": "Neutrophils produce IL-1\u03b2 in response to large particles.", "negative": "Guanine nucleotide exchange factors (GEFs) mediate RhoA activation in response to tensional forces on fibronectin-binding integrins.", "negatives": ["Guanine nucleotide exchange factors (GEFs) mediate RhoA activation in response to tensional forces on fibronectin-binding integrins.", "Integrating classroom-based collaborative learning with Web-based collaborative learning offers the best class performance.", "Assessing treatment adherence is more beneficial to clinical practice than measuring routine outcomes.", "In S. cerevisiae, the absence of RNA surveillance pathways reduces sensitivity to high iron conditions.", "There is no known interaction between Pioneer factor OCT3/4 and major chromatin remodeling factors.", "Beta-band coherence is diminished for visible stimuli over invisible stimuli.", "The DESMOND program demonstrates no significant impact on weight loss.", "Pyridostatin stabilizes the G - quadruplex in the telomeric region.", "50% of patients exposed to radiation have activated markers of mesenchymal stem cells.", "Patients with common epithelial cancers  are more likely to have an emergency event as their first hospital admission if they live in resource-deprived areas."], "hard_negatives": ["Neutrophils produce IL-1\u03b2 in response to large particles.", "Basophils promote disease development in patients with systemic lupus erythematosus (SLE).", "Many transmembrane receptors transmit signals by long-range conformational changes in the association of alpha-helices across the plasma membrane.", "IL-10 production by monocytes inhibits CD4 + T cell response.", "Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 inhibit West Nile virus replication in cortical neurons.", "Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 encourage West Nile virus replication in cortical neurons.", "Citrullinated proteins externalized in neutrophil extracellular traps act indirectly to disrupt the inflammatory cycle.", "PD-1 triggering on monocytes enhances IL-10 production by monocytes.", "The deamination of cytidine to uridine on the minus strand of viral DNA can inactivate the viral genome by inducing G-to-A mutations.", "Immune complex triggered cell death leads to sequestration of oxidized mitochondrial DNA."], "hard_negative": "Neutrophils produce IL-1\u03b2 in response to large particles."}
{"query_id": "848", "query_text": "Nigerian physicians constitue the largest component of sub-Saharan Africa-trained physicians in the United States.", "negative": "EGR2 is important to myelination of the peripheral nervous system.", "negatives": ["EGR2 is important to myelination of the peripheral nervous system.", "Blocking the interaction between TDP-43 and respiratory complex I proteins ND3 and ND6 prevents TDP-43-induced neuronal loss.", "The effect of Lipopolysaccharides on kidney barrier function is dependent on inflammation levels.", "Progerin induces premature aging in stem cells.", "There is no increased risk of hypospadias with clomiphene.", "Replacement of OCT4 and SOX2 genes with GATA3 has the ability to reprogram human cells.", "In breast cancer, the loss of myoepithelial cells promotes the transition of ductal carcinoma in situ to invasive carcinoma.", "Reduction of purity of cytoplasmic membranes isolated from overexpressors is indicated by stronger spots for OmpA in 2D BN-PAGE gels.", "Risk-adjusted mortality rates are similar in teaching and non-teaching hospitals.", "Aggravated inflammation is dependent on NLRP3 inflammasome activation."], "hard_negatives": ["Nigerian physicians constitue the largest component of sub-Saharan Africa-trained physicians in the United States.", "Algerian physicians constitue the largest component of sub-Saharan Africa-trained physicians in the United States.", "Students who perform poorly in the early years of medical school are less likely to commit professional misconduct later in their careers.", "Students who perform poorly in the early years of medical school are at increased risk for professional misconduct later in their careers.", "Risk-adjusted mortality rates are similar in teaching and non-teaching hospitals.", "Urbanization is an important risk factor related to the transmission of dengue fever.", "Rising temperatures caused by global warming increases risk of dengue fever transmission.", "76-85% of people with severe mental disorder receive no treatment in low and middle income countries.", "Integrated care is successful at tackling multiple comorbidities.", "Rising temperatures caused by global warming lowers the risk of dengue fever transmission."], "hard_negative": "Nigerian physicians constitue the largest component of sub-Saharan Africa-trained physicians in the United States."}
{"query_id": "853", "query_text": "Nonhuman primates are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.", "negative": "TNFAIP3 is a glioblastoma tumor enhancer.", "negatives": ["TNFAIP3 is a glioblastoma tumor enhancer.", "Foxp3 enables the expression of transcriptional regulators implicated in memory T cell development.", "Systemic immunosuppressive (IS) therapy increases the chance of cancer mortality in patients with inflammatory eye disease (IED)", "Noninvasive positive pressure ventilation is not predictive of acute respiratory failure after solid organ transplantation.", "The DESMOND program demonstrates no significant impact on lifestyles outcomes.", "Myelin sheaths play a role in action potential propagation.", "Bone Marrow (BM) transplantation is used to treat acute myeloid leukemia (AML)", "Broadly HIV-1 Neutralizing Antibodies (bnAb) 10EB have no affinity for phospholipids.", "Medications to treat obesity have unwanted side effects.", "Risk-adjusted mortality rates are similar in teaching and non-teaching hospitals."], "hard_negatives": ["Nonhuman primates are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.", "Eilat virus (EILV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in nonhuman primates.", "Mice are incapable of producing neutralizing antibodies in reponse to the Chikungunya virus (CHIKV) produced in mosquitos.", "Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 inhibit West Nile virus replication in cortical neurons.", "Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 encourage West Nile virus replication in cortical neurons.", "Malaria has a high vectorial capacity.", "Tuberculosis-induced granulomas express different immune system protein signatures than the surrounding tissue.", "Inside the body, falciparum parasites reproduce asexually.", "The innate immune response struggles to remove small numbers of parasites.", "The latent infection of myeloid cells with human cytomegalovirus induces a number of changes in gene expression."], "hard_negative": "Nonhuman primates are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos."}
{"query_id": "854", "query_text": "Nonhypertensive people who are 55 years old have a 90% chance of developing hypertension during their lifetime.", "negative": "PRC1-bound plasmids sediment at a slower rate in unbound plasmids than in sucrose gradients.", "negatives": ["PRC1-bound plasmids sediment at a slower rate in unbound plasmids than in sucrose gradients.", "BLM gene encodes RecQ-class DNA helicase.", "A 100g dose of chloroquine chemoprophylactic regimen results in retinal toxicity after 5-6 years of weekly intake.", "Individuals with Alzheimers who participate in six months of physical activity improve cognitive function for up to 18 months.", "MafA ubiquitination decreases the recruitment of coavtivator P/CAF by MafA.", "Increase of p62 in prostate tumor stroma results in defective autophagy.", "Increased vessel density along with a reduction in fibrosis improves the efficacy of chemotherapy treatments.", "Vaccinating the gastrointestinal tract induces protection of rectal and vaginal mucosa.", "The Snf1 complex regulates carbon and energy metabolism in baker's yeast (Saccharomyces cerevisiae).", "Antimicrobial agents are less effective due to the pressure of antimicrobial usage."], "hard_negatives": ["Nonhypertensive people who are 55 years old have a 90% chance of developing hypertension during their lifetime.", "Ambulatory blood pressure monitoring is inaccurate at diagnosing hypertension.", "Sudden death can occur in patients with orthostatic hypertension without cardiac conduction abnormalities.", "For every 1,000 children with cerebral palsy, more than 300 of them are premature or underweight at birth.", "In young and middle-aged adults, current or remote uses of ADHD medications increase the risk of serious cardiovascular events.", "Diabetes remission occurs less in people treated with conventional therapy than in people treated with laparoscopic adjustable gastric banding surgery.", "Diabetes remission occurs more in people treated with conventional therapy than in people treated with laparoscopic adjustable gastric banding surgery.", "Participants who quit smoking reduce lung cancer risk by approximately 50%.", "Decreased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm.", "Increased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm."], "hard_negative": "Nonhypertensive people who are 55 years old have a 90% chance of developing hypertension during their lifetime."}
{"query_id": "855", "query_text": "Noninvasive positive pressure ventilation is not predictive of acute respiratory failure after solid organ transplantation.", "negative": "Side effects associated with antidepressants do not represent a mortality risk to postmenopausal women.", "negatives": ["Side effects associated with antidepressants do not represent a mortality risk to postmenopausal women.", "MafA phosphorylation decreases its ubiquitination.", "Traditional reviews are biased in their interpretations.", "Consumption of whole fruits increases the risk of type 2 diabetes.", "Chenodeoxycholic acid treatment decreases brown adipose tissue activity.", "Ribosomal protein (RP) expression is controlled in part by stress-activated regulators.", "Integrated care is ineffective at tackling multiple comorbidities.", "Foxp3 enables the expression of transcriptional regulators implicated in memory T cell development.", "Guanine nucleotide dissociation inhibitor (Rho-GDI) interacts with the p75 NTR death domain", "V-9302 inhibits antitumor responses by decreasing cell death and oxidative stress."], "hard_negatives": ["Noninvasive positive pressure ventilation is not predictive of acute respiratory failure after solid organ transplantation.", "Allogeneic mechanical circulatory support is not as effective as autologous mechanical circulatory support for treating acute myocardial infarction.", "Sudden death can occur in patients with complex ventricular arrhythmias.", "Ambulatory blood pressure monitoring is inaccurate at diagnosing hypertension.", "Decreased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm.", "Increased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm.", "Sudden death can occur in patients with orthostatic hypertension without cardiac conduction abnormalities.", "High levels of CRP lead to a higher risk of exacerbations in chronic obstructive pulmonary disease (COPD).", "Gastric lavage is an effective treatment for acute paraquat poisoning.", "AMP-activated protein kinase (AMPK) activation reduces inflammation-related fibrosis in the lungs."], "hard_negative": "Noninvasive positive pressure ventilation is not predictive of acute respiratory failure after solid organ transplantation."}
{"query_id": "856", "query_text": "Nonsteroidal antinflammatory drugs are ineffective as cancer treatments.", "negative": "Self-advocacy training is effective at decreasing homelessness.", "negatives": ["Self-advocacy training is effective at decreasing homelessness.", "Incidence of sepsis has fallen substantially from 2009 to 2014.", "BLM gene encodes RecQ-class DNA helicase.", "Replacement of OCT4 and SOX2 genes with GATA3 has the ability to reprogram human cells.", "The risk of cancer rises with level of alcohol consumption.", "Beta-band coherence is enhanced for visible stimuli over invisible stimuli.", "Mutations in G-Beta protein GNB1 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.", "Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes fibrosis.", "Excess gestational weight gain is associated with obesity-related pregnancy outcomes.", "PRC1-bound plasmids sediment at a slower rate in unbound plasmids than in sucrose gradients."], "hard_negatives": ["Nonsteroidal antinflammatory drugs are ineffective as cancer treatments.", "Nonsteroidal antinflammatory drugs show potential anticancer indications.", "Side effects associated with antidepressants do not represent a mortality risk to postmenopausal women.", "A breast cancer patient's capacity to metabolize tamoxifen influences treatment outcome.", "Cancers that initially benefit from epidermal growth factor receptor targeted therapies later become refractory through several mechanisms.", "Side effects associated with antidepressants increases risk of stroke.", "The relationship between a breast cancer patient's capacity to metabolize tamoxifen and treatment outcome is independent of the patient's genetic make-up.", "The most prevalent adverse events to Semaglutide are cardiovascular.", "Sildenafil worsens erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.", "Monoclonal antibody targeting of N-cadherin encourages metastasis."], "hard_negative": "Nonsteroidal antinflammatory drugs are ineffective as cancer treatments."}
{"query_id": "857", "query_text": "Nonsteroidal antinflammatory drugs show potential anticancer indications.", "negative": "Deletion of ATM and Rad3 related protein is not predictive of acute tissue loss.", "negatives": ["Deletion of ATM and Rad3 related protein is not predictive of acute tissue loss.", "Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes epithelial damage.", "The risk of cancer rises with level of alcohol consumption.", "Students who perform poorly in the early years of medical school are less likely to commit professional misconduct later in their careers.", "Active caspase-11 participate in regulating phagosome-lysosome fusion.", "Bariatric surgery reduces colorectal cancer.", "Obesity raises life quality.", "N348I mutations cause resistance to nevirapine.", "Higher plasma levels of I-carnitine, when associated with trimethylamine N-oxide, are negatively correlated with cardiovascular events in humans.", "Adult tissue-resident macrophages are seeded before birth."], "hard_negatives": ["Nonsteroidal antinflammatory drugs show potential anticancer indications.", "Nonsteroidal antinflammatory drugs are ineffective as cancer treatments.", "Side effects associated with antidepressants increases risk of stroke.", "Side effects associated with antidepressants do not represent a mortality risk to postmenopausal women.", "The most prevalent adverse events to Semaglutide are cardiovascular.", "Side effects associated with antidepressants lower risk of myocardial infarction.", "Antidepressants reduce the severity of migraines.", "The most prevalent adverse events to Semaglutide are gastrointestinal.", "Antidepressants increase the severity of migraines.", "Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission."], "hard_negative": "Nonsteroidal antinflammatory drugs show potential anticancer indications."}
{"query_id": "858", "query_text": "Normal expression of RUNX1 causes tumorsupressing effects.", "negative": "Autologous transplantation of mesenchymal stem cells has better graft function than induction therapy with anti-interleukin-2 receptor antibodies.", "negatives": ["Autologous transplantation of mesenchymal stem cells has better graft function than induction therapy with anti-interleukin-2 receptor antibodies.", "The G34R/V mutation does not create a hypomethylated phenotype at the H3K36 histone.", "Guanine nucleotide exchange factors (GEFs) mediate RhoA activation in response to tensional forces on fibronectin-binding integrins.", "90% of patients with melanoma and an objective response to PD-1 blockade will experience a progression in their melanoma.", "The proliferative capacity of progenitors is regulated cell-autonomously.", "Crossover hot spots are found within gene promoters in Saccharomyces cerevisiae.", "The mean suicide rate in women is lower after miscarriage than live birth.", "The microtubule-dependent delivery and secretion of matrix metalloproteases (MMPs) is partially responsible for the disassembly of adhesion sites.", "In domesticated populations of Saccharomyces cerevisiae, segmental aneuploidy occurs infrequently.", "There is a positive correlation between hip fractures and statin use."], "hard_negatives": ["Normal expression of RUNX1 causes tumorsupressing effects.", "ALDH1 expression is associated with poorer prognosis for breast cancer primary tumors.", "RUNX1 is downregulated or mutated in TLX1 T-ALL.", "RUNX is not expressed in skin tissue.", "Upregulation of PD1 causes the upregulation of Satb1.", "Upregulation of PD1 causes the downmodulation of Satb1.", "Increase of p62 in prostate tumor stroma results in defective autophagy.", "Decrease of p62 in prostate tumor stroma results in defective autophagy.", "PD-1 triggering on monocytes enhances IL-10 production by monocytes.", "Activation of PPM1D enhances p53 function."], "hard_negative": "Normal expression of RUNX1 causes tumorsupressing effects."}
{"query_id": "860", "query_text": "Normal granulomas form in the absence of TNF in Zebrafish.", "negative": "Pharmacist attendance at ward rounds reduces adverse events in wards.", "negatives": ["Pharmacist attendance at ward rounds reduces adverse events in wards.", "Cnn1 recruitment varies with cell cycle timing.", "Deltex interacts with eIF3. There is no known interaction between Deltex and elF3", "Hypocretin neurones suppress panicprone state in rats.", "Induced hepatic stem cells possess the potential to differentiate into cholangiocytic cells.", "Including pharmacists in rounding teams reduces the incidence of adverse drug events (ADEs).", "Pyridostatin stabilizes the G - quadruplex in the telomeric region.", "ATM and Rad3 related protein are critical for sensing DNA damage.", "Venules have less significant tunica adventitia than arterioles.", "Pyridostatin decreases telomere fragility in BRCA2-deficient cells."], "hard_negatives": ["Normal granulomas form in the absence of TNF in Zebrafish.", "Normal granulomas form in the presence of TNF in Zebrafish.", "Tuberculosis-induced granulomas express different immune system protein signatures than the surrounding tissue.", "The tissue surrounding the granuloma in an immune cell induces an anti-inflammatory immune response.", "Neutrophils produce IL-1\u03b2 in response to large particles.", "Mice are incapable of producing neutralizing antibodies in reponse to the Chikungunya virus (CHIKV) produced in mosquitos.", "Mice that lack Interferon-\u03b3 or its receptor are highly susceptible to experimental autoimmune myocarditis.", "The latent infection of myeloid cells with human cytomegalovirus induces a number of changes in gene expression.", "Nonhuman primates are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.", "Eilat virus (EILV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in nonhuman primates."], "hard_negative": "Normal granulomas form in the absence of TNF in Zebrafish."}
{"query_id": "861", "query_text": "Normal granulomas form in the presence of TNF in Zebrafish.", "negative": "Ribosome-inactivating protein-2 (RIP-2) interacts with the p75 NTR death domain", "negatives": ["Ribosome-inactivating protein-2 (RIP-2) interacts with the p75 NTR death domain", "A 100g dose of chloroquine chemoprophylactic regimen results in retinal toxicity after 5-6 years of weekly intake.", "Assessing treatment adherence is more beneficial to clinical practice than measuring routine outcomes.", "Deleting Raptor increases G-CSF levels.", "Activated Cdk5 regulates DNA damage-induced neuronal death.", "B3-Galectin increases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR.", "Vitamin D deficiency effects birth weight.", "Replacement of histone H2A with H2A.Z accelerates gene activation in yeasts by destabilizing +1 nucleosomes.", "Lipopolysaccharides have an inflammation independent effect on kidney barrier function.", "Lice attenuated SIV vaccines induce a stronger antigen-specific T cell response in lymph node cells."], "hard_negatives": ["Normal granulomas form in the presence of TNF in Zebrafish.", "Normal granulomas form in the absence of TNF in Zebrafish.", "Tuberculosis-induced granulomas express different immune system protein signatures than the surrounding tissue.", "The tissue surrounding the granuloma in an immune cell induces an anti-inflammatory immune response.", "Neutrophils produce IL-1\u03b2 in response to large particles.", "Mice are incapable of producing neutralizing antibodies in reponse to the Chikungunya virus (CHIKV) produced in mosquitos.", "Mice that lack Interferon-\u03b3 or its receptor are highly susceptible to experimental autoimmune myocarditis.", "The latent infection of myeloid cells with human cytomegalovirus induces a number of changes in gene expression.", "Eilat virus (EILV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in nonhuman primates.", "Nonhuman primates are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos."], "hard_negative": "Normal granulomas form in the presence of TNF in Zebrafish."}
{"query_id": "863", "query_text": "Notch signaling occurs between tumor cells and stromal cells.", "negative": "Physical activity level has no association with the difference in maximal oxygen consumption between black and white youth.", "negatives": ["Physical activity level has no association with the difference in maximal oxygen consumption between black and white youth.", "7-day-old adult Caenorhabditis elegans exhibit approximately 5% of the learning capacity seen in 1-day old adults.", "Tirasemtiv has no effect on cardiac muscle.", "CD44v6 is not associated with constitutive and reprogrammed cancer stem cells driving cancer metastasis.", "Less than 10% of patients exposed to radiation have activated markers of mesenchymal stem cells.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have increased risk for Alzheimer's disease.", "HNF4A mutations are associated with macrosomia in infancy.", "B cells go though plasmablast differentiation and antibody production by continuous expression of EBI2.", "H4 G94P proteins inhibit chromatin assembly, which decreases free histones.", "Pediatric SCD patients with vaso-occlusive crisis show increased morphine use after breathing 80 ppm iNO for 4 hours."], "hard_negatives": ["Notch signaling occurs between tumor cells and stromal cells.", "Tumor development occurs in conjunction with upregulation of pro-inflammatory cytokines.", "Pro-inflammatory cytokines are up regulated during tumor development.", "Tumor development occurs in conjunction with suppression of pro-inflammatory cytokines.", "Cancer-associated fibroblasts (CAFs) interact with cancer cells to mediate formation and activation of CAFs.", "ALDH1 expression is associated with poorer prognosis for breast cancer primary tumors.", "Pro-inflammatory cytokines are up repressed during tumor development.", "In breast cancer, the loss of myoepithelial cells promotes the transition of ductal carcinoma in situ to invasive carcinoma.", "Cancer-associated fibroblasts (CAFs) have no known interaction with cancer cells in the formation and activation of CAFs.", "Myelin sheaths play a role in action potential propagation."], "hard_negative": "Notch signaling occurs between tumor cells and stromal cells."}
{"query_id": "866", "query_text": "Nuclear transfer from adult human fibroblasts to human oocytes can give rise to blastocysts containing expandable pluripotent cells.", "negative": "Pyridostatin stabilizes the G - quadruplex in the telomeric region.", "negatives": ["Pyridostatin stabilizes the G - quadruplex in the telomeric region.", "32% of liver transplantation programs required patients to discontinue methadone treatment in 2001.", "The innate immune response struggles to remove small numbers of parasites.", "Cytosolic proteins bind to iron-responsive elements on mRNAs coding for TFRC1.", "AZT given with ribavirin increases anemia.", "CRP is positively correlated with postoperative mortality following Coronary Artery Bypass Graft (CABG) surgery.", "Distant CREs are less conserved among species.", "Replacement of OCT4 and SOX2 genes with GATA3 has the ability to reprogram human cells.", "Beta-band coherence is enhanced for visible stimuli over invisible stimuli.", "There is no increased risk of hypospadias with clomiphene."], "hard_negatives": ["Nuclear transfer from adult human fibroblasts to human oocytes can give rise to blastocysts containing expandable pluripotent cells.", "Human embryonic stem cells give rise to cell types from the outer embryonic germ layer, but not the other two layers.", "Cancer-associated fibroblasts (CAFs) have no known interaction with cancer cells in the formation and activation of CAFs.", "Cancer-associated fibroblasts (CAFs) interact with cancer cells to mediate formation and activation of CAFs.", "Cellular differentiation of embryonic stem cells is accompanied by changes in replication timing, transcription and nuclear localization.", "Human embryonic stem cells have the capacity to give rise to differentiated progeny representative of all three embryonic germ layers.", "Mitochondria play a major role in energy production.", "Human embryonic stem cells give rise to cell types from all three embryonic germ layers.", "Cancer cells can stimulate the accumulation of intra-tumoural myeloid-derived suppressor cells by promoting granulocyte colony stimulating factor production.", "Cardiac tissue-resident macrophages directly contribute to electrical activity."], "hard_negative": "Nuclear transfer from adult human fibroblasts to human oocytes can give rise to blastocysts containing expandable pluripotent cells."}
{"query_id": "867", "query_text": "Oat tolerant coeliac patients may have oat specific inflammatory cells in their small bowel mucosa.", "negative": "YAP/TAZ is required in intestinal regeneration in mouse models of ulcerative colitis.", "negatives": ["YAP/TAZ is required in intestinal regeneration in mouse models of ulcerative colitis.", "L3MBTL2 binds to H2AK119Ub marked chromatin to form a PRC1 complex.", "Bacteriophagaes MS2 and Q\u03b2 are members of the Leviviridae.", "Retinoic acid receptor-related orphan receptor gamma (ROR\u03b3) is a therapeutic target for castration-resistant prostate cancer (CRPC)", "ART has no effect on the infectiveness of HIV-positive people.", "Incidence of heart failure increased by 10% in women since 1979.", "0-dimensional biomaterials lack inductive properties.", "The most prevalent adverse events to Semaglutide are cardiovascular.", "Pyridostatin reduces proliferation of homologous recombination - defective cells.", "Chlamydia trachomatis is most prevalent in the UK among sexually-experienced individuals aged 16 to 24."], "hard_negatives": ["Oat tolerant coeliac patients may have oat specific inflammatory cells in their small bowel mucosa.", "Vaccinating the gastrointestinal tract induces protection of rectal and vaginal mucosa.", "Systemic immunosuppressive (IS) therapy increases the chance of cancer mortality in patients with inflammatory eye disease (IED)", "Systemic immunosuppressive (IS) therapy does not enhance the chance of cancer mortality in patients with inflammatory eye disease (IED)", "Bacterial meningitis can be diagnosed on the basis of positive cerebrospinal fluid (CSF) cultures.", "Gastric infection with Helicobacter pylori increases risk of gastric cancer in humans.", "Gastric infection with Helicobacter pylori decreases risk of gastric cancer in humans.", "The most prevalent adverse events to Semaglutide are gastrointestinal.", "The effect of Lipopolysaccharides on kidney barrier function is dependent on inflammation levels.", "In rhesus macaques, daily subcutaneous injections of emtricitabine are ineffective at protecting against rectally transmitted simian-human immunodeficiency virus."], "hard_negative": "Oat tolerant coeliac patients may have oat specific inflammatory cells in their small bowel mucosa."}
{"query_id": "871", "query_text": "Obesity decreases life quality.", "negative": "Physical activity level is associated with the difference in maximal oxygen consumption between black and white youth.", "negatives": ["Physical activity level is associated with the difference in maximal oxygen consumption between black and white youth.", "Primary cervical cancer screening with HPV detection has lower longitudinal sensitivity than conventional cytology to detect cervical intraepithelial neoplasia grade 2.", "0-dimensional biomaterials lack inductive properties.", "Overexpressing Cnp1 N-tail variants exacerbates the temperature-sensitive growth defect of scm3-139.", "Lack of FGF21 in mice leads to reduced lifespan.", "Deletion of ATM and Rad3 related protein leads to acute tissue loss.", "Oxidative phosphorylation is one of the primary glycometabolic pathways in cells.", "Sudden death can occur in patients with complex ventricular arrhythmias.", "p75 NTR - associated cell death executor (NADE) interacts with the p75 NTR death domain", "Decreased conversion of PGE 2 to PPARy ligand 15-ket-PGE 2 causes accumulation of PGE."], "hard_negatives": ["Obesity decreases life quality.", "Obesity raises life quality.", "Exercise reduces cancer mortality rates among Chinese citizens.", "Exercise increases cancer mortality rates among Chinese citizens.", "Suboptimal nutrition is a leading cause of premature death", "Excess gestational weight gain is associated with obesity-related pregnancy outcomes.", "Vitamin D deficiency effects birth weight.", "Medications to treat obesity are highly effective.", "Insulin decreases risk of severe kidney failure.", "Autophagy deficiency in the liver increases vulnerability to insulin resistance."], "hard_negative": "Obesity decreases life quality."}
{"query_id": "876", "query_text": "Obesity raises life quality.", "negative": "Microcin J25 encourages nucleoside triphosphate (NTP) binding.", "negatives": ["Microcin J25 encourages nucleoside triphosphate (NTP) binding.", "Deletion of ATM and Rad3 related protein is not predictive of acute tissue loss.", "Pseudogene PTENP1 encodes a transcript that regulates PTEN expression.", "Binding of p53 to enhancer regions (p53BERs) regulates the activity of p53 transcription and cell cycle arrest through the production of p53-dependent eRNAs.", "Neutrophil extracellular trap (NET) antigens may contain the targeted autoantigens PR3 and MPO.", "AZT given with ribavirin increases anemia.", "Bcp1 is a chaperone for Rpl23.", "Neutrophils produce IL-1\u03b2 in response to large particles.", "Eliminating the last sporadic cases of malaria requires considerable funding.", "Exhaustion of B cells contributes to poor Ab response in HIV-infected individuals."], "hard_negatives": ["Obesity raises life quality.", "Obesity decreases life quality.", "Exercise increases cancer mortality rates among Chinese citizens.", "Exercise reduces cancer mortality rates among Chinese citizens.", "Medications to treat obesity are highly effective.", "Prescribed exercise training improves quality of life.", "Medications to treat obesity have unwanted side effects.", "Suboptimal nutrition is a leading cause of premature death", "Medications to treat obesity do not have side effects.", "Excess gestational weight gain is associated with obesity-related pregnancy outcomes."], "hard_negative": "Obesity raises life quality."}
{"query_id": "877", "query_text": "Occipital activation levels are associated with auditory spatial performance in parietal regions of the brain.", "negative": "4-PBA treatment decreases endoplasmic reticulum stress in response to general endoplasmic reticulum stress markers.", "negatives": ["4-PBA treatment decreases endoplasmic reticulum stress in response to general endoplasmic reticulum stress markers.", "Patients with common epithelial cancers are less likely to have an emergency event as their first hospital admission if they live in resource-deprived areas.", "Healthy volunteers exhibit rapid and transient increase of cellular ATP after being bolus-injected with fructose.", "One in two surgical randomized controlled trials are discontinued early.", "Tuberculosis incidence occurs at higher rates in more sparsely populated areas in the UK.", "A breast cancer patient's capacity to metabolize tamoxifen influences treatment outcome.", "Microcin J25 encourages nucleoside triphosphate (NTP) binding.", "Sudden death can occur in patients with complex ventricular arrhythmias.", "Tirasemtiv targets cardiac muscle.", "PKG-la does not have a large impact on expression of spinal long term potentiation in PGK-la knockout mice."], "hard_negatives": ["Occipital activation levels are associated with auditory spatial performance in parietal regions of the brain.", "Headaches are correlated with cognitive impairment.", "Hypothalamic glutamate neurotransmission is unrelated to energy balance.", "Energy balance requires hypothalamic glutamate neurotransmission.", "Glial calcium waves influence seizures.", "Insulin effects appetite via ventral tegmental neurons.", "The density of cytokine receptor bearing cells affects the distance over which cytokines act.", "The cytokine receptor which regulates chemotaxis and formation of lymph nodes is involved in production of myeloperoxidase in the left atrium.", "The density of cytokine receptor bearing cells has no effect on the distance over which cytokines act.", "Exposure to fine particulate air pollution is unrelated to anxiety prevalence."], "hard_negative": "Occipital activation levels are associated with auditory spatial performance in parietal regions of the brain."}
{"query_id": "881", "query_text": "Omnivores produce less trimethylamine N-oxide from dietary I-carnitine than vegans.", "negative": "Drosophila supracellular actomyosin structures are found at boundaries in wing imaginal discs.", "negatives": ["Drosophila supracellular actomyosin structures are found at boundaries in wing imaginal discs.", "ITAM phosphorylation allows for the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).", "Natriuretic peptides increase susceptibility to diabetes.", "Cancer-associated fibroblasts (CAFs) are constituents of tumor microenvironments", "T cell receptor /CD3 microdomains are required to induce the immunologic synapse.", "Tirasemtiv targets cardiac muscle.", "Treatment with a protein named FN impairs regenerative abilities of aged muscles.", "A deficiency of vitamin B6 decreases blood levels of homocysteine.", "Differentiated E2f-1, -2, -3 TKO cells in the intestine do not exhibit apoptosis.", "The DEXI promoter region is bound by multiple transcription factors in a murine haematopoietic progenitor cell line."], "hard_negatives": ["Omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegans.", "Omnivores produce less trimethylamine N-oxide from dietary I-carnitine than vegans.", "Omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegetarians.", "Higher plasma levels of I-carnitine, when associated with trimethylamine N-oxide, are negatively correlated with cardiovascular events in humans.", "Higher plasma levels of I-carnitine, when associated with trimethylamine N-oxide, are positively correlated with cardiovascular events in humans.", "The most prevalent adverse events to Semaglutide are gastrointestinal.", "Sildenafil worsens erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.", "Long chain polyunsaturated fatty acids supplementation reduces wheezing and asthma.", "Intake of folic acid (FA) and vitamin B6 (VB6) reduces levels of homocysteine.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have shorter lifetime exposure to estrogen due to a decreased reproductive period."], "hard_negative": "Omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegans."}
{"query_id": "883", "query_text": "Omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegans.", "negative": "Microglia are an innate immune cell type of the peripheral nervous system.", "negatives": ["Microglia are an innate immune cell type of the peripheral nervous system.", "Replacement of OCT4 and SOX2 genes with GATA3 has the ability to reprogram human cells.", "Side effects associated with antidepressants lower risk of myocardial infarction.", "Glycan adaptation involves insertion-deletion events.", "NAC destabilizes NO to increase the effect of contrast agents on renal functions.", "The mean suicide rate in women is lower after miscarriage than live birth.", "In the UK, drowning affects boys and girls equally.", "Including pharmacists in rounding teams does not alter the incidence of adverse drug events (ADEs).", "Ten percent (10%) of kidney cancers in the UK are attributable to excess weight.", "Sildenafil worsens erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants."], "hard_negatives": ["Omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegans.", "Omnivores produce less trimethylamine N-oxide from dietary I-carnitine than vegans.", "Omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegetarians.", "Higher plasma levels of I-carnitine, when associated with trimethylamine N-oxide, are negatively correlated with cardiovascular events in humans.", "Higher plasma levels of I-carnitine, when associated with trimethylamine N-oxide, are positively correlated with cardiovascular events in humans.", "Sildenafil worsens erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.", "Long chain polyunsaturated fatty acids supplementation reduces wheezing and asthma.", "The most prevalent adverse events to Semaglutide are gastrointestinal.", "Intake of folic acid (FA) and vitamin B6 (VB6) reduces levels of homocysteine.", "LDL cholesterol has a causal role in the development of cardiovascular disease."], "hard_negative": "Omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegans."}
{"query_id": "884", "query_text": "Omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegetarians.", "negative": "Systemic immunosuppressive (IS) therapy increases the chance of cancer mortality in patients with inflammatory eye disease (IED)", "negatives": ["Systemic immunosuppressive (IS) therapy increases the chance of cancer mortality in patients with inflammatory eye disease (IED)", "EG7 tumors can be killed by systemic oxaliplatin primed CD8+ T cells from the tumor-draining lymph node cells.", "miRNAs enforce homeostasis by suppressing low-level ''leaky'' transcription.", "Sympathetic nerve activity is elevated throughout normal pregnancy.", "PrimPol degrades short DNA replication intermediates on the leading strand during DNA replication.", "Medications to treat obesity are highly effective.", "A low percentage of hematopoietic progenitor cells are susceptible to HIV-1 infection ex vivo.", "The repeat-variable diresidue (RVD) in the loop of Transcription-Activator Like (TAL) effectors specifies the nucleotides-amino acid contact at the target promoter element.", "NAC destabilizes NO to increase the effect of contrast agents on renal functions.", "Reduction of Rpl38 alters the composition of the Hox gene mRNAs translation in mice without lowering overall protein synthesis."], "hard_negatives": ["Omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegetarians.", "Omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegans.", "Omnivores produce less trimethylamine N-oxide from dietary I-carnitine than vegans.", "Higher plasma levels of I-carnitine, when associated with trimethylamine N-oxide, are negatively correlated with cardiovascular events in humans.", "Higher plasma levels of I-carnitine, when associated with trimethylamine N-oxide, are positively correlated with cardiovascular events in humans.", "Sildenafil worsens erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have longer lifetime exposure to estrogen due to an increased reproductive period.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have shorter lifetime exposure to estrogen due to a decreased reproductive period.", "Thiopurine active metabolites can be catabolized through dephosphorylation of thioguanine nucleotides.", "Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission."], "hard_negative": "Omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegetarians."}
{"query_id": "885", "query_text": "One in five surgical randomized controlled trials are discontinued early.", "negative": "Induced hepatic stem cells possess the potential to differentiate into cholangiocytic cells.", "negatives": ["Induced hepatic stem cells possess the potential to differentiate into cholangiocytic cells.", "Mice without IFN-\u03b3 or its receptor are highly susceptible to EAM induced with \u03b1-MyHC/CFA.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have decreased risk for dementia.", "Cancer-associated fibroblasts (CAFs) are constituents of tumor microenvironments", "MFGE8 regulates fat absorption by binding to av-Beta3 and av-Beta5 integrins.", "Klf2 is important for proper myeloid cell function.", "MafA ubiquitination decreases the recruitment of coavtivator P/CAF by MafA.", "Reduction of purity of cytoplasmic membranes isolated from overexpressors is indicated by stronger spots for OmpA in 2D BN-PAGE gels.", "The most prevalent adverse events to Semaglutide are cardiovascular.", "In breast cancer, the loss of myoepithelial cells slows the transition of ductal carcinoma in situ to invasive carcinoma."], "hard_negatives": ["One in five surgical randomized controlled trials are discontinued early.", "One in two surgical randomized controlled trials are discontinued early.", "32% of liver transplantation programs required patients to discontinue methadone treatment in 2001.", "Therapeutics receiving accelerated approval encounter a lower frequency of post-marketing safety events", "70% of burn patients are admitted for hospitalization and further treatment after appearing at hospital emergency wards or outpatient clinics.", "Risk-adjusted mortality rates are similar in teaching and non-teaching hospitals.", "Early patent ductus ateriosus (PDA) screening decreases in-hospital mortality.", "90% of patients with melanoma and an objective response to PD-1 blockade will experience a progression in their melanoma.", "Early patent ductus ateriosus (PDA) screening increases in-hospital mortality.", "1-1% of colorectal cancer patients are diagnosed with regional or distant metastases."], "hard_negative": "One in five surgical randomized controlled trials are discontinued early."}
{"query_id": "886", "query_text": "One in two surgical randomized controlled trials are discontinued early.", "negative": "Omnivores produce less trimethylamine N-oxide from dietary I-carnitine than vegans.", "negatives": ["Omnivores produce less trimethylamine N-oxide from dietary I-carnitine than vegans.", "Egr2 regulates the homeostasis of B and T cells.", "Tonic signaling from the scFv prevents constitutive stimulation.", "Immune complex triggered cell death leads to extracellular release of nuclear DNA.", "Students who perform poorly in the early years of medical school are less likely to commit professional misconduct later in their careers.", "Mice without IFN-\u03b3 or its receptor are highly susceptible to EAM induced with \u03b1-MyHC/CFA.", "Combination nicotine replacement therapies with varenicline or bupropion are more effective after 12 weeks of reatment compared to varenicline monotherapy.", "Pseudoknots are not evolutionarily conserved in most eukaryotes.", "Pioglitazone use is not associated with an increased risk of prostate cancer.", "miR-142-5P is a known regulator of raised body temperature."], "hard_negatives": ["One in five surgical randomized controlled trials are discontinued early.", "One in two surgical randomized controlled trials are discontinued early.", "32% of liver transplantation programs required patients to discontinue methadone treatment in 2001.", "Therapeutics receiving accelerated approval encounter a lower frequency of post-marketing safety events", "70% of burn patients are admitted for hospitalization and further treatment after appearing at hospital emergency wards or outpatient clinics.", "Risk-adjusted mortality rates are similar in teaching and non-teaching hospitals.", "90% of patients with melanoma and an objective response to PD-1 blockade will experience a progression in their melanoma.", "Early patent ductus ateriosus (PDA) screening decreases in-hospital mortality.", "Early patent ductus ateriosus (PDA) screening increases in-hospital mortality.", "In patients with congenital heart defects, \u03b2-blockers significantly improve clinical heart failure outcomes."], "hard_negative": "One in five surgical randomized controlled trials are discontinued early."}
{"query_id": "890", "query_text": "Origin gross domestic product(GDP) is negatively related to dengue virus (DENV-1) diffusion in air traffic shipments.", "negative": "Certain immunomodulator-human dialyzable leukocyte extract (hDLE) peptides are recognized by toll-like receptors (TLRs) on macrophages and dendritic cells.", "negatives": ["Certain immunomodulator-human dialyzable leukocyte extract (hDLE) peptides are recognized by toll-like receptors (TLRs) on macrophages and dendritic cells.", "70% of burn patients are admitted for hospitalization and further treatment after appearing at hospital emergency wards or outpatient clinics.", "RANK-RANKL pathway signalling is linked to development of Aire-expressing medullary thymic epithelial cells.", "Broadly HIV-1 Neutralizing Antibodies (bnAb) 10EB have no affinity for phospholipids.", "The deregulated and prolonged activation of monocytes improves inflammatory disease outcomes.", "Upon viral challenge, influenza-specific memory CD4+ T cells greatly diminish the early production of inflammatory chemokines in the lung.", "RTEL1 interacts with TRF2 through a C4C4 motif", "Sudden death can occur in patients with orthostatic hypertension without cardiac conduction abnormalities.", "Eilat virus (EILV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in nonhuman primates.", "MFGE8 regulates fat absorption by binding to av-Beta3 and av-Beta5 integrins."], "hard_negatives": ["Origin gross domestic product(GDP) is negatively related to dengue virus (DENV-1) diffusion in air traffic shipments.", "Origin gross domestic product(GDP) is positively related to dengue virus (DENV-1) diffusion in air traffic shipments.", "Destination container port throughput(CPT) is negatively related to dengue virus (DENV-1) diffusion in air traffic shipments.", "Destination container port throughput(CPT) is positively related to dengue virus (DENV-1) diffusion in air traffic shipments.", "Rising temperatures caused by global warming increases risk of dengue fever transmission.", "Urbanization is an important risk factor related to the transmission of dengue fever.", "Rising temperatures caused by global warming lowers the risk of dengue fever transmission.", "Epidemiological disease burden from noncommunicable diseases is more prevalent in high economic settings.", "Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 inhibit West Nile virus replication in cortical neurons.", "Malaria has a high vectorial capacity."], "hard_negative": "Origin gross domestic product(GDP) is negatively related to dengue virus (DENV-1) diffusion in air traffic shipments."}
{"query_id": "891", "query_text": "Origin gross domestic product(GDP) is positively related to dengue virus (DENV-1) diffusion in air traffic shipments.", "negative": "British female students are bullied more than British male students.", "negatives": ["British female students are bullied more than British male students.", "Genes regulated by Esrrb transcription factor are sensitive to Mbd3 function.", "Pre-mRNAs associated with spliceosomal components are less stable than unassociated splicing substrates.", "Blocking the interaction between TDP-43 and respiratory complex I proteins ND3 and ND6 prevents TDP-43-induced neuronal loss.", "32% of liver transplantation programs required patients to discontinue methadone treatment in 2001.", "A T helper 2 cell (Th2) environment impedes disease development in patients with systemic lupus erythematosus (SLE).", "Omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegetarians.", "Localization of PIN1 in the roots of Arabidopsis requires VPS9a", "Nonhypertensive people who are 55 years old have a 90% chance of developing hypertension during their lifetime.", "Omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegans."], "hard_negatives": ["Origin gross domestic product(GDP) is positively related to dengue virus (DENV-1) diffusion in air traffic shipments.", "Origin gross domestic product(GDP) is negatively related to dengue virus (DENV-1) diffusion in air traffic shipments.", "Destination container port throughput(CPT) is positively related to dengue virus (DENV-1) diffusion in air traffic shipments.", "Destination container port throughput(CPT) is negatively related to dengue virus (DENV-1) diffusion in air traffic shipments.", "Urbanization is an important risk factor related to the transmission of dengue fever.", "Rising temperatures caused by global warming increases risk of dengue fever transmission.", "Rising temperatures caused by global warming lowers the risk of dengue fever transmission.", "Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 encourage West Nile virus replication in cortical neurons.", "Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 inhibit West Nile virus replication in cortical neurons.", "Malaria has a high vectorial capacity."], "hard_negative": "Origin gross domestic product(GDP) is positively related to dengue virus (DENV-1) diffusion in air traffic shipments."}
{"query_id": "893", "query_text": "Osteocytes have an essential role in G-CSF induced HSPC mobilization.", "negative": "Lack of FGF21 in mice leads to atherosclerotic plaque formation.", "negatives": ["Lack of FGF21 in mice leads to atherosclerotic plaque formation.", "BiP is a general endoplasmic reticulum stress marker.", "Students who perform poorly in the early years of medical school are less likely to commit professional misconduct later in their careers.", "Smc5/6 engagment halts the activation of SUMO E3 ligase Mms21 by ATP-dependent remolding.", "Lamins are associated with nuclear membrane structure maintenance.", "Tumor development occurs in conjunction with upregulation of pro-inflammatory cytokines.", "10% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.", "Activator-inhibitor pairs are provided ventrally by Xrl-sizzled.", "Removal of H3K9me3 improves reprogramming efficiency in human somatic cell nuclear transfer experiments.", "AZT given with ribavirin increases anemia."], "hard_negatives": ["Osteocytes have an essential role in G-CSF induced HSPC mobilization.", "The cytokine receptor which regulates chemotaxis and formation of lymph nodes is involved in production of myeloperoxidase in the left atrium.", "F4/80+ macrophages regulate mature osteoblast maintenance.", "Cancer-associated fibroblasts (CAFs) interact with cancer cells to mediate formation and activation of CAFs.", "Oxidative phosphorylation is one of the primary glycometabolic pathways in cells.", "Induced hepatic stem cells possess the potential to differentiate into cholangiocytic cells.", "Cancer cells can stimulate the accumulation of intra-tumoural myeloid-derived suppressor cells by promoting granulocyte colony stimulating factor production.", "G-CSF increases the expansion and infiltration of MDSCs into tumors.", "Cancer-associated fibroblasts (CAFs) have no known interaction with cancer cells in the formation and activation of CAFs.", "Klf4 is important for proper myeloid cell differentiation."], "hard_negative": "Osteocytes have an essential role in G-CSF induced HSPC mobilization."}
{"query_id": "894", "query_text": "Osteoparthritis (OA) is characterized by degeneration of articular cartilage, joint edge, and subchondral bone hyperplasia.", "negative": "Venules have less significant tunica adventitia than arterioles.", "negatives": ["Venules have less significant tunica adventitia than arterioles.", "Asymptomatic visual impairment screening in elderly populations leads to improved vision.", "Dscam1 acts as a hypervariable pattern-recognition receptor for the immune system.", "Pyridostatin encourages proliferation of homologous recombination - defective cells.", "Induction of urokinase receptor signaling in podocytes causes foot process effacement and proteinuria.", "Suboptimal nutrition is a leading cause of premature death", "Helicobacter pylori-induced aberrant NF-kB-dependent expression of activation-induced cytidine deaminase contributes to the mutagenesis of host DNA.", "Human embryonic stem cells give rise to cell types from the outer embryonic germ layer, but not the other two layers.", "Klf2 is important for proper myeloid cell function.", "7-day-old adult Caenorhabditis elegans exhibit approximately 75% of the learning capacity seen in 1-day old adults."], "hard_negatives": ["Osteoparthritis (OA) is characterized by degeneration of articular cartilage, joint edge, and subchondral bone hyperplasia.", "Surgical treatment is not superior to non-surgical in treating adults with displaced fractures of the proximal humerus.", "F4/80+ macrophages regulate mature osteoblast maintenance.", "Roughly 55% of women with chronic pelvic pain have no underlying pathology.", "Sudden death can occur in patients with orthostatic hypertension without cardiac conduction abnormalities.", "Rotator cuff exercises are more effective than general exercise therapy in reducing pain and improving function of the shoulder.", "Angiotensin converting enzyme inhibitors are associated with decreased risk for functional renal insufficiency.", "Interleukin-18 plays an important role in the pathogenesis of atherosclerosis.", "Glioblastoma multiforme (GBM) is characterized by extensive invasion, rapid growth, necrosis, and angiogenesis.", "General exercise therapy is more effective than rotator cuff exercises in reducing pain and improving function of the shoulder."], "hard_negative": "Osteoparthritis (OA) is characterized by degeneration of articular cartilage, joint edge, and subchondral bone hyperplasia."}
{"query_id": "895", "query_text": "Over half of the gabonese children with Schimmelpenning-Feuerstein-Mims syndrome (SFM) had a plasma lactate of more than 5mmol/L.", "negative": "Inside the body, falciparum parasites reproduce asexually.", "negatives": ["Inside the body, falciparum parasites reproduce asexually.", "Glycan adaptation involves insertion-deletion events.", "Individuals with low serum vitamin D concentrations have decreased risk of multiple sclerosis.", "Pioglitazone use is not associated with an increased risk of prostate cancer.", "Transplanted human glial progenitor cells can mature in their host animal.", "Cancer-associated fibroblasts (CAFs) have no known interaction with cancer cells in the formation and activation of CAFs.", "Osteoparthritis (OA) is characterized by degeneration of articular cartilage, joint edge, and subchondral bone hyperplasia.", "Removal of H3K9me3 by ectopic expression of other H3K9 demethylases decreases reprogramming efficiency in SCNT experiments.", "Ethanol stress reduces the expression of SRL in bacteria.", "Ribosome-inactivating protein-2 (RIP-2) interacts with the p75 NTR death domain"], "hard_negatives": ["Over half of the gabonese children with Schimmelpenning-Feuerstein-Mims syndrome (SFM) had a plasma lactate of more than 5mmol/L.", "Mutant mice lacking SVCT2 have severely reduced ascorbic acid levels in both brain and adrenals.", "For every 1,000 children with cerebral palsy, more than 300 of them are premature or underweight at birth.", "Patients with microcytosis and higher erythrocyte count were more resistant to severe malarial anaemia when infected with Plasmodium falciparum.", "Nonhypertensive people who are 55 years old have a 90% chance of developing hypertension during their lifetime.", "There was an estimated 30 million cases of pneumonia in young children worldwide in 2010.", "Taxation of sugar-sweetened beverages reduced the incidence rate of type II diabetes in India.", "Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission.", "Pediatric SCD patients with vaso-occlusive crisis show increased morphine use after breathing 80 ppm iNO for 4 hours.", "A T helper 2 cell (Th2) environment impedes disease development in patients with systemic lupus erythematosus (SLE)."], "hard_negative": "Over half of the gabonese children with Schimmelpenning-Feuerstein-Mims syndrome (SFM) had a plasma lactate of more than 5mmol/L."}
{"query_id": "896", "query_text": "Overexpressing Cnp1 N-tail variants exacerbates the temperature-sensitive growth defect of scm3-139.", "negative": "Medications to treat obesity have unwanted side effects.", "negatives": ["Medications to treat obesity have unwanted side effects.", "Antimicrobial agents are more effective due to the pressure of antimicrobial usage.", "The mean suicide rate in women is higher after miscarriage than live birth.", "Patients with microcytosis and higher erythrocyte count were more resistant to severe malarial anaemia when infected with Plasmodium falciparum.", "CD28 initiates tonic signaling in conventional T cells, which causes an exhaustion phenotype and limited efficiency.", "The composition of myosin-II isoform switches from the A isoform to the B isoform during hematopoietic differentiation.", "The recruitment of Wdr5 to its target loci depends on Kat8.", "Tonic signaling from the scFv is amplified by MyD88/CD40.", "MUC1-C activates the NF-\u03baB p65 signaling pathway by interacting with I\u03baB kinase \u00df.", "Mice that lack Interferon-\u03b3 or its receptor are highly susceptible to experimental autoimmune myocarditis."], "hard_negatives": ["Overexpressing Cnp1 N-tail variants exacerbates the temperature-sensitive growth defect of scm3-139.", "Overexpressing Cnp1 N-tail variants rescues the temperature-sensitive growth defect of scm3-139.", "miR-142-5P is a temperature-sensitive microRNA (miRNA).", "mcm 5 s 2 U is required for proper decoding of NNR codons in eukaryotes.", "Activation of PPM1D enhances p53 function.", "miR-142-5P is a known regulator of raised body temperature.", "Concentrations of SNV and CNV in stem-cell regulatory elements and binding sites of transcription factors in iPSC-lines are distinct from their founding cells.", "The predominant localization of Linc00173 is in mononuclear macrophage nuclei.", "There is no known interaction between Pioneer factor OCT3/4 and major chromatin remodeling factors.", "Mutations in RIM1 raise levels of IME1 RNA."], "hard_negative": "Overexpressing Cnp1 N-tail variants exacerbates the temperature-sensitive growth defect of scm3-139."}
{"query_id": "897", "query_text": "Overexpressing Cnp1 N-tail variants rescues the temperature-sensitive growth defect of scm3-139.", "negative": "Increased mobility of retrotransposons does not lead to mutation and higher tumorigenesis rates.", "negatives": ["Increased mobility of retrotransposons does not lead to mutation and higher tumorigenesis rates.", "Lack of FGF21 in mice increases life expectancy.", "Genomic aberrations of metastases provide information for targeted therapy.", "Splenomegaly is observed in knockin mouse lacking the SHP-2 MAPK pathway.", "The PPR MDA5 has twenty N-terminal CARD domains.", "Cholesterol loading induces KLF4 expression in VSMCs, resulting in the expression of pro-inflammatory cytokines.", "siRNA knockdown of A20 slows tumor progression in an in vivo murine xenograft model.", "Genomic aberrations of metastases provide information for targeted therapy.", "In domesticated populations of Saccharomyces cerevisiae, segmental aneuploidy is very common.", "Monoclonal antibody targeting of N-cadherin encourages metastasis."], "hard_negatives": ["Overexpressing Cnp1 N-tail variants exacerbates the temperature-sensitive growth defect of scm3-139.", "Overexpressing Cnp1 N-tail variants rescues the temperature-sensitive growth defect of scm3-139.", "miR-142-5P is a temperature-sensitive microRNA (miRNA).", "mcm 5 s 2 U is required for proper decoding of NNR codons in eukaryotes.", "Activation of PPM1D enhances p53 function.", "During non-homologous end joining, the ligation step is not as tolerant of disrepairs and other distortions when joining 5' of strand breaks as compared to 3' strand breaks.", "miR-142-5P is a known regulator of raised body temperature.", "Concentrations of SNV and CNV in stem-cell regulatory elements and binding sites of transcription factors in iPSC-lines are distinct from their founding cells.", "During non-homologous end joining, the ligation step is not as tolerant of disrepairs and other distortions when joining 3' of strand breaks as compared to 5' strand breaks.", "The predominant localization of Linc00173 is in mononuclear macrophage nuclei."], "hard_negative": "Overexpressing Cnp1 N-tail variants exacerbates the temperature-sensitive growth defect of scm3-139."}
{"query_id": "898", "query_text": "Oxidative DNA damage activates STING signalling.", "negative": "DUSP4 decreases apoptosis.", "negatives": ["DUSP4 decreases apoptosis.", "Weighed food records (WFR) result in high completion since they're cheap to run and impose low participant burden.", "Origin gross domestic product(GDP) is positively related to dengue virus (DENV-1) diffusion in air traffic shipments.", "A 100g dose of chloroquine chemoprophylactic regimen results in retinal toxicity after 1 year of weekly intake.", "ALDH1 expression is associated with poorer prognosis for breast cancer primary tumors.", "LRBA prevents CTLA - 4 recycling.", "ScPif1p has reduced binding ability to G-rich ssDNA compared to non-G-rich ssDNA.", "Increased lipolysis leads to higher P38 phosphorylation in adipose tissue.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have shorter lifetime exposure to estrogen due to a decreased reproductive period.", "Upregulation of PD1 causes the downmodulation of Satb1."], "hard_negatives": ["Oxidative DNA damage activates STING signalling.", "Oxidative DNA damage inhibits STING signalling.", "IFI16 impedes STING phosphorylation and translocation, resulting in reduced activation of STING.", "Immune complex triggered cell death leads to sequestration of oxidized mitochondrial DNA.", "Immune complex triggered cell death leads to extracellular release of nuclear DNA.", "Neutrophils produce IL-1\u03b2 in response to large particles.", "Eilat virus (EILV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in nonhuman primates.", "The deamination of cytidine to uridine on the minus strand of viral DNA can inactivate the viral genome by inducing G-to-A mutations.", "Citrullinated proteins externalized in neutrophil extracellular traps act indirectly to perpetuate the inflammatory cycle via induction of autoantibodies.", "Citrullinated proteins externalized in neutrophil extracellular traps act indirectly to disrupt the inflammatory cycle."], "hard_negative": "Oxidative DNA damage activates STING signalling."}
{"query_id": "899", "query_text": "Oxidative DNA damage inhibits STING signalling.", "negative": "Intramembrane cleavage by signal peptide peptidase aids in the degradation of proteins with a complex membrane orientation.", "negatives": ["Intramembrane cleavage by signal peptide peptidase aids in the degradation of proteins with a complex membrane orientation.", "Diabetes remission occurs less in people treated with conventional therapy than in people treated with laparoscopic adjustable gastric banding surgery.", "MICAL redox enzymes regulate actin dynamics in many cell types.", "Allogeneic mechanical circulatory support is not as effective as autologous mechanical circulatory support for treating acute myocardial infarction.", "Diabetes remission occurs more in people treated with conventional therapy than in people treated with laparoscopic adjustable gastric banding surgery.", "Increased lipolysis leads to higher P38 phosphorylation in adipose tissue.", "CD44v6 is not associated with constitutive and reprogrammed cancer stem cells driving cancer metastasis.", "Normal granulomas form in the presence of TNF in Zebrafish.", "The ability of activator E2Fs in preventing cell death is limited to terminally differentiated cells.", "Deletion of ATM and Rad3 related protein is not predictive of acute tissue loss."], "hard_negatives": ["Oxidative DNA damage activates STING signalling.", "Oxidative DNA damage inhibits STING signalling.", "IFI16 impedes STING phosphorylation and translocation, resulting in reduced activation of STING.", "Immune complex triggered cell death leads to sequestration of oxidized mitochondrial DNA.", "Eilat virus (EILV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in nonhuman primates.", "Neutrophils produce IL-1\u03b2 in response to large particles.", "Immune complex triggered cell death leads to extracellular release of nuclear DNA.", "Nonhuman primates are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.", "Mice are incapable of producing neutralizing antibodies in reponse to the Chikungunya virus (CHIKV) produced in mosquitos.", "The deamination of cytidine to uridine on the minus strand of viral DNA can inactivate the viral genome by inducing G-to-A mutations."], "hard_negative": "Oxidative DNA damage activates STING signalling."}
{"query_id": "900", "query_text": "Oxidative phosphorylation is one of the primary glycometabolic pathways in cells.", "negative": "Bariatric surgery reduces colorectal cancer.", "negatives": ["Bariatric surgery reduces colorectal cancer.", "Genomic sequences involved in alternative splicing responsible for Hutchinson-Gilford progeria syndrome (HGPS) are abundant in the ''progerinonly'' allele of Lmna knock-in models.", "The DESMOND program caused substantial weight loss in most participants.", "Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes fibrosis.", "Omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegetarians.", "Aged patients are less susceptible to ischaemia/reperfusion injury.", "Traditional reviews are biased in their interpretations.", "Two variants of chromosome 6q21 are associated with radiation therapy-induced second malignancies in pediatric Hodgkin lymphoma patients.", "Consumption of whole fruits increases the risk of type 2 diabetes.", "Ethanol stress increases the expression of SRL in bacteria."], "hard_negatives": ["Oxidative phosphorylation is one of the primary glycometabolic pathways in cells.", "Mitochondria play a major role in energy production.", "Osteocytes have an essential role in G-CSF induced HSPC mobilization.", "Mitochondria play a major role in apoptosis.", "Hypothalamic glutamate neurotransmission is unrelated to energy balance.", "The Snf1 complex regulates carbon and energy metabolism in baker's yeast (Saccharomyces cerevisiae).", "Increased lipolysis leads to higher P38 phosphorylation in adipose tissue.", "Energy balance requires hypothalamic glutamate neurotransmission.", "Pyridostatin stabilizes the G - quadruplex in the telomeric region.", "MICAL redox enzymes regulate actin dynamics in many cell types."], "hard_negative": "Oxidative phosphorylation is one of the primary glycometabolic pathways in cells."}
{"query_id": "901", "query_text": "PCSK9 inhibitors decrease plasma Lp(a) levels.", "negative": "Osteocytes have an essential role in G-CSF induced HSPC mobilization.", "negatives": ["Osteocytes have an essential role in G-CSF induced HSPC mobilization.", "Pyridostatin stabilizes the G - quadruplex in the telomeric region.", "Ultrasound guidance significantly reduces the number of needle insertion attempts necessary for a given procedure.", "Cyclin A2 destruction is necessary to switch from unstable to stable kt-mt attachments in mitosis.", "4-PBA treatment raises endoplasmic reticulum stress in response to general endoplasmic reticulum stress markers.", "Foxk2 regulates autophagy genes in muscle cells and fibroblast cells.", "Moderate consumption of candy and chocolate reduces the risk of cardiovascular disease (CVD).", "Rhythmic expression of Cry1 translates directly into a circadian regulation of cAMP signaling in hepatic glucose metabolism.", "GATA3 regulates self-renewal capacity in bone marrow hematopoietic stem cells.", "Increased LDL receptors plays a role in the reduction of plasma Lp(a)."], "hard_negatives": ["PCSK9 inhibitors decrease plasma Lp(a) levels.", "Increased LDL receptors plays a role in the reduction of plasma Lp(a).", "In melanoma, anti-CTLA-4 treatment reinvigorates exhausted PD-1+Eomes+CD8 T cells.", "Inhibiting glucose-6-phospate dehydrogenase improves lipogenesis by deactivating LKB1-AMPK signaling.", "In chronic viral infections or tumors, peptides that selectively inhibit PTPRS can be utilized to boost insufficient activity of pDCs.", "PKG-la does not have a large impact on expression of pain hypersensitivity in PGK-la knockout mice.", "Reduced phosphorylation of PP2A increases HDAC4 dephosphorylation by enhancing PP2A-HDAC4 interaction.", "Reduced levels of lipolysis leads to higher P38 phosphorylation in adipose tissue.", "Reduced phosphorylation of PP2A suppresses HDAC4 dephosphorylation.", "90% of patients with melanoma and an objective response to PD-1 blockade will experience a progression in their melanoma."], "hard_negative": "PCSK9 inhibitors decrease plasma Lp(a) levels."}
{"query_id": "902", "query_text": "PD-1 triggering on monocytes enhances IL-10 production by monocytes.", "negative": "JMJD6 slows the hydroxylation of C-terminal lysine", "negatives": ["JMJD6 slows the hydroxylation of C-terminal lysine", "Angiotensin converting enzyme inhibitors are associated with decreased risk for functional renal insufficiency.", "LRBA promotes CTLA - 4 recycling.", "Reduction of purity of cytoplasmic membranes isolated from overexpressors is indicated by stronger spots for OmpA in 2D BN-PAGE gels.", "Replacement of OCT4 and SOX2 genes with GATA3 has the ability to reprogram human cells.", "Tonic signaling from the scFv prevents constitutive stimulation.", "Retinoic acid receptor-related orphan receptor gamma (ROR\u03b3) is a therapeutic target for castration-resistant prostate cancer (CRPC)", "Glycan adaptation involves insertion-deletion events.", "Omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegans.", "Antidepressants increase the severity of migraines."], "hard_negatives": ["PD-1 triggering on monocytes enhances IL-10 production by monocytes.", "IL-10 production by monocytes inhibits CD4 + T cell response.", "Upregulation of PD1 causes the upregulation of Satb1.", "Activated Cdk5 regulates DNA damage-induced neuronal death.", "The minor G allele of FOXO3 up-regulates IL-10.", "Activation of PPM1D enhances p53 function.", "Upregulation of PD1 causes the downmodulation of Satb1.", "The deregulated and prolonged activation of monocytes improves inflammatory disease outcomes.", "IL-6 signaling plays a major role in atherosclerotic cardiovascular disease.", "Repressing IL-18 has negative effects on atherosclerotic lesion composition and progression."], "hard_negative": "PD-1 triggering on monocytes enhances IL-10 production by monocytes."}
{"query_id": "908", "query_text": "PGE 2 suppresss intestinal tumor growth by altering the expression of tumor suppressing and DNA repair genes.", "negative": "Bacteriophagaes MS2 and Q\u03b2 are members of the Leviviridae.", "negatives": ["Bacteriophagaes MS2 and Q\u03b2 are members of the Leviviridae.", "Egr2 regulates the homeostasis of B and T cells.", "Increased vessel density along with a reduction in fibrosis improves the efficacy of chemotherapy treatments.", "Obesity decreases life quality.", "T cell receptor /CD3 microdomains are required to induce the immunologic synapse.", "Asymptomatic visual impairment screening in elderly populations leads to improved vision.", "Myelin sheaths play a role in action potential propagation.", "Piezo1 channels are sensors for cell migration in epithelial cells.", "Vitamin D deficiency effects birth weight.", "Lipopolysaccharides have an inflammation independent effect on kidney barrier function."], "hard_negatives": ["PGE 2 suppresss intestinal tumor growth by altering the expression of tumor suppressing and DNA repair genes.", "PKG-la does not have a large impact on expression of pain hypersensitivity in PGK-la knockout mice.", "Activation of PPM1D enhances p53 function.", "Increased conversion of PGE 2 to PPARy ligand 15-ket-PGE 2 causes accumulation of PGE.", "Decreased conversion of PGE 2 to PPARy ligand 15-ket-PGE 2 causes accumulation of PGE.", "Decrease of p62 in prostate tumor stroma results in defective autophagy.", "Increase of p62 in prostate tumor stroma results in defective autophagy.", "Many cytokines that are produced by cancer cells also contribute to carcinogenesis.", "Cancer-associated fibroblasts (CAFs) have no known interaction with cancer cells in the formation and activation of CAFs.", "Up-regulation of the p53 pathway and related molecular events speeds cancer progression."], "hard_negative": "PGE 2 suppresss intestinal tumor growth by altering the expression of tumor suppressing and DNA repair genes."}
{"query_id": "909", "query_text": "PKG-la does not have a large impact on expression of pain hypersensitivity in PGK-la knockout mice.", "negative": "Microglia are an innate immune cell type of the central nervous system.", "negatives": ["Microglia are an innate immune cell type of the central nervous system.", "Pyridostatin reduces proliferation of homologous recombination - defective cells.", "Forkhead 0 (fox0) transcription factors are involved in apoptosis.", "PKG-la does not have a large impact on expression of spinal long term potentiation in PGK-la knockout mice.", "Intra-cerebroventricular infusion of amyloid-\u03b2 oligomers increases expression of fibronectin type-III domain-containing protein 5 mRNA in mice hippocampi.", "Monoclonal antibody targeting of N-cadherin inhibits castration resistance.", "The PRDM1 gene, when combined with the PRDM14 gene, plays an important role during primordial germ cell specification.", "In British Men, haplogroup I increases risk of cardiovascular disease by 50%.", "Mutations in RIM1 decrease levels of IME1 RNA.", "In domesticated populations of Saccharomyces cerevisiae, segmental aneuploidy is very common."], "hard_negatives": ["PKG-la does not have a large impact on expression of pain hypersensitivity in PGK-la knockout mice.", "PKG-la does not have a large impact on expression of spinal long term potentiation in PGK-la knockout mice.", "PKG-la plays an essential role in expression of spinal long term potentiation in PGK-la knockout mice.", "The minor G allele of FOXO3 downregulates pro-inflammatory cytokines.", "PGE 2 suppresss intestinal tumor growth by altering the expression of tumor suppressing and DNA repair genes.", "Activation of PPM1D enhances p53 function.", "Foxp3 represses the expression of transcriptional regulators implicated in memory T cell development.", "Rhythmic expression of Cry1 translates directly into a circadian regulation of cAMP signaling in gluconeogenesis.", "PCSK9 inhibitors decrease plasma Lp(a) levels.", "Decreased conversion of PGE 2 to PPARy ligand 15-ket-PGE 2 causes accumulation of PGE."], "hard_negative": "PKG-la does not have a large impact on expression of pain hypersensitivity in PGK-la knockout mice."}
{"query_id": "910", "query_text": "PKG-la does not have a large impact on expression of spinal long term potentiation in PGK-la knockout mice.", "negative": "TNFAIP3 is a tumor enhancer in glioblastoma.", "negatives": ["TNFAIP3 is a tumor enhancer in glioblastoma.", "Men are more susceptible to death due to pneumonia when compared to women.", "Patients with common epithelial cancers  are more likely to have an emergency event as their first hospital admission if they live in resource-deprived areas.", "Activated Cdk5 phosphorylates the ATM protein in response to DNA damage.", "Myelin sheaths play a role in action potential propagation.", "The DESMOND program demonstrates no significant impact on lifestyles outcomes.", "Consumption of whole fruits increases the risk of type 2 diabetes.", "BCL-2 promotes the apoptotic effects of c-Myc.", "Ca2+ cycling is a UCP1-independent thermogenic mechanism.", "Converting apoE4 to apoE3 by gene editing prevents the pathology associated with apoE4 in human iPSCderived neurons."], "hard_negatives": ["PKG-la does not have a large impact on expression of spinal long term potentiation in PGK-la knockout mice.", "PKG-la plays an essential role in expression of spinal long term potentiation in PGK-la knockout mice.", "PKG-la does not have a large impact on expression of pain hypersensitivity in PGK-la knockout mice.", "Foxp3 represses the expression of transcriptional regulators implicated in memory T cell development.", "Activation of PPM1D enhances p53 function.", "Foxp3 enables the expression of transcriptional regulators implicated in memory T cell development.", "The minor G allele of FOXO3 downregulates pro-inflammatory cytokines.", "Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes fibrosis.", "Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes epithelial damage.", "FoxO3a activation in neuronal death is inhibited by reactive oxygen species (ROS)."], "hard_negative": "PKG-la does not have a large impact on expression of spinal long term potentiation in PGK-la knockout mice."}
{"query_id": "912", "query_text": "PKG-la plays an essential role in expression of spinal long term potentiation in PGK-la knockout mice.", "negative": "Exercise reduces cancer mortality rates among Chinese citizens.", "negatives": ["Exercise reduces cancer mortality rates among Chinese citizens.", "KRT17 modulates the expression of the transcriptional regulator AIRE in diseased epithelia.", "Stacking is more stable when a purine is present in the +5 position (C1698).", "RAD52 is involved in break-induced DNA replication (BIR).", "Increased mobility of retrotransposons is assosciated with mutation and higher tumorigenesis rates.", "Citrullinated proteins externalized in neutrophil extracellular traps act indirectly to disrupt the inflammatory cycle.", "Mice that lack Interferon-\u03b3 or its receptor are highly susceptible to experimental autoimmune myocarditis.", "76-85% of people with severe mental disorder receive no treatment in low and middle income countries.", "The cytokine receptor which regulates chemotaxis and formation of lymph nodes is involved in production of myeloperoxidase in the left atrium.", "Two variants of chromosome 6q21 are associated with radiation therapy-induced second malignancies in pediatric Hodgkin lymphoma patients."], "hard_negatives": ["PKG-la plays an essential role in expression of spinal long term potentiation in PGK-la knockout mice.", "PKG-la does not have a large impact on expression of spinal long term potentiation in PGK-la knockout mice.", "PKG-la does not have a large impact on expression of pain hypersensitivity in PGK-la knockout mice.", "Foxp3 represses the expression of transcriptional regulators implicated in memory T cell development.", "Foxp3 enables the expression of transcriptional regulators implicated in memory T cell development.", "Activation of PPM1D enhances p53 function.", "Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes fibrosis.", "The minor G allele of FOXO3 downregulates pro-inflammatory cytokines.", "Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes epithelial damage.", "Rhythmic expression of Cry1 translates directly into a circadian regulation of cAMP signaling in gluconeogenesis."], "hard_negative": "PKG-la plays an essential role in expression of spinal long term potentiation in PGK-la knockout mice."}
{"query_id": "916", "query_text": "PRC1-bound plasmids sediment at a slower rate in unbound plasmids than in sucrose gradients.", "negative": "Self-advocacy training is effective at decreasing homelessness.", "negatives": ["Self-advocacy training is effective at decreasing homelessness.", "Sudden death can occur in patients with orthostatic hypertension without cardiac conduction abnormalities.", "Medications to treat obesity do not have side effects.", "The number of unfertilized oocytes in mated hermaphrodites increases with age.", "Intra-cerebroventricular infusion of amyloid-\u03b2 oligomers reduces expression of fibronectin type-III domain-containing protein 5 mRNA in mice hippocampi.", "TRAP+ osteoclasts regulate mature osteoblast maintenance.", "A deficiency of folate increases blood levels of homocysteine.", "Bariatric surgery reduces colorectal cancer.", "Activation of the Rac1 homolog CED-10 kills viable cells in SRGP-1 mutant Caenorhabditis elegans.", "Replacement of OCT4 and SOX2 genes with GATA3 is not capable of reprogramming human cells."], "hard_negatives": ["PRC1-bound plasmids sediment at a slower rate in unbound plasmids than in sucrose gradients.", "L3MBTL2 binds to H2AK119Ub marked chromatin to form a PRC1 complex.", "Stiff substrates inhibit mesodermal differentiation by degrading beta-catenin in an integrin-dependent manner.", "Lamins have no effect on nuclear membrane structure maintenance.", "Increased purity of cytoplasmic membranes isolated from overexpressors is indicated by stronger spots for OmpF in 2D BN-PAGE gels.", "Lamins are found within the inner layer of the mitochondrial membrane of all cells.", "Lamins are associated with nuclear membrane structure maintenance.", "Myelin sheaths are lipid-rich cellular structures.", "Stiff substrates encourage mesodermal differentiation by degrading beta-catenin in an integrin-dependent manner.", "The predominant localization of Linc00173 is in mononuclear macrophage nuclei."], "hard_negative": "PRC1-bound plasmids sediment at a slower rate in unbound plasmids than in sucrose gradients."}
{"query_id": "917", "query_text": "PTEN is a regulator for the transcriptional activity of SRF", "negative": "In a naive state, blocking Wingless-Int-1 secretion from mouse embryonic stem cells inhibits self-renewal of the mouse embryonic stem cells.", "negatives": ["In a naive state, blocking Wingless-Int-1 secretion from mouse embryonic stem cells inhibits self-renewal of the mouse embryonic stem cells.", "Diabetic patients with acute coronary syndrome experience decreased short-term and long-term risk for bleeding events.", "Lice attenuated SIV vaccines induce a stronger antigen-specific T cell response in lymph node cells.", "There was an estimated 30 million cases of pneumonia in young children worldwide in 2010.", "Expression of oncolytic virus antigens as peptides makes relapse more likely.", "Rapamycin increases the concentration of triacylglycerols in fruit flies.", "90% of patients with melanoma and an objective response to PD-1 blockade will experience a progression in their melanoma.", "Klf4 is important for proper myeloid cell differentiation.", "1 in 5 million in UK have abnormal PrP positivity.", "Lamins are associated with nuclear membrane structure maintenance."], "hard_negatives": ["PTEN is a regulator for the transcriptional activity of SRF", "Pseudogene PTENP1 encodes a transcript that regulates PTEN expression.", "TNFAIP3 is a glioblastoma tumor suppressor.", "Binding of p53 to enhancer regions (p53BERs) regulates the activity of p53 transcription and cell cycle arrest through the production of p53-dependent eRNAs.", "Fibroblast growth factor 21 protects against atherosclerosis by modulating adiponectin and SREBP2 levels.", "TNFAIP3 is a tumor enhancer in glioblastoma.", "TNFAIP3 is a glioblastoma tumor enhancer.", "Activation of PPM1D enhances p53 function.", "KRT17 modulates the expression of the transcriptional regulator AIRE in diseased epithelia.", "Foxp3 enables the expression of transcriptional regulators implicated in memory T cell development."], "hard_negative": "PTEN is a regulator for the transcriptional activity of SRF"}
{"query_id": "919", "query_text": "Participants who quit smoking reduce lung cancer risk by approximately 50%.", "negative": "Adult tissue-resident macrophages are seeded before birth.", "negatives": ["Adult tissue-resident macrophages are seeded before birth.", "In pediatric tissue, most T cells are naive T cell emigrants from the thymus.", "Improvements in OER catalysts show stable activity over several hundred hours.", "Genes regulated by Esrrb transcription factor are sensitive to Mbd3 function.", "DUSP4 downregulation deactivates the Ras-ERK pathway", "C2 works synergistically with A-769662 to activate dephosphorylated AMPK.", "Microglia are an innate immune cell type of the central nervous system.", "Immune responses in immune cells are geographically segregated.", "The DESMOND program caused substantial weight loss in most participants.", "Citrullinated proteins externalized in neutrophil extracellular traps act indirectly to perpetuate the inflammatory cycle via induction of autoantibodies."], "hard_negatives": ["Participants who quit smoking reduce lung cancer risk by approximately 50%.", "Women with a lower birth weight are more likely to develop breast cancer later in life.", "High levels of CRP lead to a higher risk of exacerbations in chronic obstructive pulmonary disease (COPD).", "Pioglitazone use is significantly associated with an increased risk of pancreatic cancer.", "Exercise reduces cancer mortality rates among Chinese citizens.", "The risk of cancer rises with level of alcohol consumption.", "Pioglitazone use is not associated with an increased risk of prostate cancer.", "Pioglitazone use is significantly associated with an increased risk of prostate cancer.", "Exercise increases cancer mortality rates among Chinese citizens.", "In young and middle-aged adults, current or remote uses of ADHD medications increase the risk of serious cardiovascular events."], "hard_negative": "Participants who quit smoking reduce lung cancer risk by approximately 50%."}
{"query_id": "923", "query_text": "Patients in stable partnerships have a slower progression from HIV to AIDS.", "negative": "Self-advocacy training is effective at decreasing homelessness.", "negatives": ["Self-advocacy training is effective at decreasing homelessness.", "The Snf1 complex regulates carbon and energy metabolism in baker's yeast (Saccharomyces cerevisiae).", "Environmentally-induced senescence is mimicked in disease modeling by adding specific molecules to the culture system.", "Long chain polyunsaturated fatty acids supplementation is associated with lower rates of atopic eczema at 1 year.", "Activated Cdk5 phosphorylates the ATM protein in response to DNA damage.", "Homozygous deletion of murine Sbds gene from osterix-expressing mesenchymal stem and progenitor cells (MPCs) induces oxidative stress.", "Foxp3 enables the expression of transcriptional regulators implicated in memory T cell development.", "Risk-adjusted mortality rates are similar in teaching and non-teaching hospitals.", "Overexpressing Cnp1 N-tail variants rescues the temperature-sensitive growth defect of scm3-139.", "The effect of Lipopolysaccharides on kidney barrier function is dependent on inflammation levels."], "hard_negatives": ["Patients in stable partnerships have a slower progression from HIV to AIDS.", "Patients in stable partnerships progress from HIV to death at the same rate as patients not in partnerships.", "Having a main partner worsens HIV outcomes.", "Having a main partner improves HIV outcomes.", "Exhaustion of B cells contributes to poor Ab response in HIV-infected individuals.", "ART has no effect on the infectiveness of HIV-positive people.", "Chronic HIV stimulation of B cells leads to the premature exhaustion of B cells.", "Antiretroviral therapy increases rates of tuberculosis across a broad range of CD4 strata.", "ART substantially reduces infectiveness of HIV-positive people.", "A low percentage of hematopoietic progenitor cells are susceptible to HIV-1 infection ex vivo."], "hard_negative": "Patients in stable partnerships have a slower progression from HIV to AIDS."}
{"query_id": "925", "query_text": "Patients in stable partnerships progress from HIV to death at the same rate as patients not in partnerships.", "negative": "Differentiation of progenitor cells to myeloid cells is skewed upon activation of insulin signaling.", "negatives": ["Differentiation of progenitor cells to myeloid cells is skewed upon activation of insulin signaling.", "Taking 400mg of \u03b1-tocopheryl acetate in combination with vitamin C reduces the risk of prostate cancer.", "Women are more susceptible to death due to pneumonia when compared to men.", "In chronic viral infections or tumors, peptides that selectively inhibit PTPRS can be utilized to boost insufficient activity of pDCs.", "Comparative transcriptome analysis identified new platelet proteins with structural features suggesting a role in platelet function.", "The DdrB protein from Deinococcus radiodurans functions as a pentamer.", "Venules have less significant tunica adventitia than arterioles.", "A single nucleotide variant the gene DGKK is strongly associated with increased risk of hypospadias.", "Lamins are associated with nuclear membrane structure maintenance.", "Sympathetic nerve activity is reduced throughout normal pregnancy."], "hard_negatives": ["Patients in stable partnerships progress from HIV to death at the same rate as patients not in partnerships.", "Patients in stable partnerships have a slower progression from HIV to AIDS.", "Having a main partner worsens HIV outcomes.", "Having a main partner improves HIV outcomes.", "Chronic HIV stimulation of B cells leads to the premature exhaustion of B cells.", "Exhaustion of B cells contributes to poor Ab response in HIV-infected individuals.", "Antiretroviral therapy increases rates of tuberculosis across a broad range of CD4 strata.", "ART has no effect on the infectiveness of HIV-positive people.", "The mean suicide rate in women is lower after miscarriage than live birth.", "Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission."], "hard_negative": "Patients in stable partnerships progress from HIV to death at the same rate as patients not in partnerships."}
{"query_id": "926", "query_text": "Patients with common epithelial cancers  are more likely to have an emergency event as their first hospital admission if they live in resource-deprived areas.", "negative": "Antidepressants reduce the severity of migraines.", "negatives": ["Antidepressants reduce the severity of migraines.", "There is no increased risk of hypospadias with clomiphene.", "There is no association between HNF4A mutations and diabetes risks.", "Long chain polyunsaturated fatty acids supplementation has no significant effects on wheezing or asthma at 3 and 6 years.", "The Snf1 complex regulates carbon and energy metabolism in baker's yeast (Saccharomyces cerevisiae).", "Urbanization is an important risk factor related to the transmission of dengue fever.", "Activated Cdk5 regulates DNA damage-induced neuronal death.", "Localization of PIN1 in the roots of Arabidopsis requires VPS9a", "Overexpressing Cnp1 N-tail variants rescues the temperature-sensitive growth defect of scm3-139.", "Pediatric SCD patients with vaso-occlusive crisis show increased morphine use after breathing 80 ppm iNO for 4 hours."], "hard_negatives": ["Patients with common epithelial cancers are less likely to have an emergency event as their first hospital admission if they live in resource-deprived areas.", "Patients with common epithelial cancers  are more likely to have an emergency event as their first hospital admission if they live in resource-deprived areas.", "70% of burn patients are admitted for hospitalization and further treatment after appearing at hospital emergency wards or outpatient clinics.", "Women with a lower birth weight are more likely to develop breast cancer later in life.", "Tuberculosis incidence occurs at higher rates in more sparsely populated areas in the UK.", "Ten percent (10%) of kidney cancers in the UK are attributable to excess weight.", "1-1% of colorectal cancer patients are diagnosed with regional or distant metastases.", "In breast cancer, the loss of myoepithelial cells promotes the transition of ductal carcinoma in situ to invasive carcinoma.", "In breast cancer, the loss of myoepithelial cells slows the transition of ductal carcinoma in situ to invasive carcinoma.", "Nonhypertensive people who are 55 years old have a 90% chance of developing hypertension during their lifetime."], "hard_negative": "Patients with common epithelial cancers are less likely to have an emergency event as their first hospital admission if they live in resource-deprived areas."}
{"query_id": "927", "query_text": "Patients with common epithelial cancers are less likely to have an emergency event as their first hospital admission if they live in resource-deprived areas.", "negative": "Ly6C hi monocytes have a higher inflammatory capacity than Ly6C lo monocytes.", "negatives": ["Ly6C hi monocytes have a higher inflammatory capacity than Ly6C lo monocytes.", "mcm 5 s 2 U is required for proper decoding of NNR codons in eukaryotes.", "The combination of physical examinations with C-reactive protein values do not improve the accuracy of radiographic verified pneumonia predictions.", "CD44v6 is not associated with constitutive and reprogrammed cancer stem cells driving cancer metastasis.", "Cholesterol loading induces KLF4 expression in VSMCs, resulting in the expression of pro-inflammatory cytokines.", "A 100g dose of chloroquine chemoprophylactic regimen results in retinal toxicity after 1 year of weekly intake.", "Intake of folic acid (FA) and vitamin B6 (VB6) increases levels of homocysteine.", "The minor G allele of FOXO3 up-regulates IL-10.", "Vitamin D is an important factor in the relationship between calcium and parathyroid hormone.", "Algerian physicians constitue the largest component of sub-Saharan Africa-trained physicians in the United States."], "hard_negatives": ["Patients with common epithelial cancers are less likely to have an emergency event as their first hospital admission if they live in resource-deprived areas.", "Patients with common epithelial cancers  are more likely to have an emergency event as their first hospital admission if they live in resource-deprived areas.", "70% of burn patients are admitted for hospitalization and further treatment after appearing at hospital emergency wards or outpatient clinics.", "Women with a lower birth weight are more likely to develop breast cancer later in life.", "Tuberculosis incidence occurs at higher rates in more sparsely populated areas in the UK.", "Ten percent (10%) of kidney cancers in the UK are attributable to excess weight.", "1-1% of colorectal cancer patients are diagnosed with regional or distant metastases.", "Risk-adjusted mortality rates are similar in teaching and non-teaching hospitals.", "Nonhypertensive people who are 55 years old have a 90% chance of developing hypertension during their lifetime.", "In breast cancer, the loss of myoepithelial cells slows the transition of ductal carcinoma in situ to invasive carcinoma."], "hard_negative": "Patients with common epithelial cancers are less likely to have an emergency event as their first hospital admission if they live in resource-deprived areas."}
{"query_id": "928", "query_text": "Patients with microcytosis and higher erythrocyte count are more vulnerable to severe malarial anaemia when infected with Plasmodium falciparum.", "negative": "Trans-acting factors, such as lncRNAs, influence mRNA translation.", "negatives": ["Trans-acting factors, such as lncRNAs, influence mRNA translation.", "The risk of breast cancer among parous women decreases with placental weight of pregnancies.", "Treatment with a protein named FN restores regenerative abilities of aged muscles.", "Exposure to fine particulate air pollution is unrelated to anxiety prevalence.", "Aggravated inflammation is dependent on NLRP3 inflammasome activation.", "Hematopoietic Stem Cell purification reaches purity rates above 90%.", "T cell receptor /CD3 microdomains are required to induce the immunologic synapse.", "Destination container port throughput(CPT) is positively related to dengue virus (DENV-1) diffusion in air traffic shipments.", "Helicobacter pylori-induced aberrant NF-kB-dependent expression of activation-induced cytidine deaminase contributes to the mutagenesis of host DNA.", "0-dimensional biomaterials lack inductive properties."], "hard_negatives": ["Patients with microcytosis and higher erythrocyte count are more vulnerable to severe malarial anaemia when infected with Plasmodium falciparum.", "Patients with microcytosis and higher erythrocyte count were more resistant to severe malarial anaemia when infected with Plasmodium falciparum.", "Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission.", "Malaria has a high vectorial capacity.", "The most prevalent adverse events to Semaglutide are gastrointestinal.", "Tuberculosis incidence occurs at higher rates in more sparsely populated areas in the UK.", "Nonhuman primates are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.", "Women are more susceptible to death due to pneumonia when compared to men.", "Stroke patients with prior use of direct oral anticoagulants have a higher risk of in-hospital mortality than stroke patients with prior use of warfarin.", "Individuals with low serum vitamin D concentrations have decreased risk of multiple sclerosis."], "hard_negative": "Patients with microcytosis and higher erythrocyte count are more vulnerable to severe malarial anaemia when infected with Plasmodium falciparum."}
{"query_id": "929", "query_text": "Patients with microcytosis and higher erythrocyte count were more resistant to severe malarial anaemia when infected with Plasmodium falciparum.", "negative": "Crossover hot spots are found within gene promoters in Saccharomyces cerevisiae.", "negatives": ["Crossover hot spots are found within gene promoters in Saccharomyces cerevisiae.", "Deleting Raptor increases G-CSF levels.", "Deltex has no known interactions with eIF3f.", "Lack of FGF21 in mice leads to reduced lifespan.", "Sequence conservation in gene regulatory regions between species is a high-accuracy predictor of conserved functionality.", "Side effects associated with antidepressants increases risk of stroke.", "Stiff substrates inhibit mesodermal differentiation by degrading beta-catenin in an integrin-dependent manner.", "Charcoal is an effective treatment for acute paraquat poisoning.", "Sequence conservation in gene regulatory regions between species is a high-accuracy predictor of conserved functionality.", "Systemic immunosuppressive (IS) therapy increases the chance of cancer mortality in patients with inflammatory eye disease (IED)"], "hard_negatives": ["Patients with microcytosis and higher erythrocyte count were more resistant to severe malarial anaemia when infected with Plasmodium falciparum.", "Patients with microcytosis and higher erythrocyte count are more vulnerable to severe malarial anaemia when infected with Plasmodium falciparum.", "Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission.", "Malaria has a high vectorial capacity.", "Nonhuman primates are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.", "The most prevalent adverse events to Semaglutide are gastrointestinal.", "Stroke patients with prior use of direct oral anticoagulants have a higher risk of in-hospital mortality than stroke patients with prior use of warfarin.", "The deamination of cytidine to uridine on the minus strand of viral DNA can inactivate the viral genome by inducing G-to-A mutations.", "Eilat virus (EILV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in nonhuman primates.", "Women are more susceptible to death due to pneumonia when compared to men."], "hard_negative": "Patients with microcytosis and higher erythrocyte count were more resistant to severe malarial anaemia when infected with Plasmodium falciparum."}
{"query_id": "930", "query_text": "Patients with panic anxiety show decreased CSF levels of hypocretin.", "negative": "Monoclonal antibody targeting of N-cadherin encourages metastasis.", "negatives": ["Monoclonal antibody targeting of N-cadherin encourages metastasis.", "Elevated cell-free mitochondrial DNA levels are associated with mortality.", "Pharmacist attendance at ward rounds reduces adverse events in wards.", "Chlamydia trachomatis is most prevalent in the UK among sexually-experienced individuals aged 16 to 24.", "Rapamycin delays aging in fruit flies.", "It is not proven that moderate consumption of candy and chocolate reduces the risk of cardiovascular disease (CVD) specifically.", "The proliferative capacity of progenitors is regulated cell-autonomously.", "aPKCz causes tumour suppression by affecting glutamine metabolism.", "Bcp1 is a chaperone for Rpl23.", "There is a relation between Erythromycin use and hypertrophic pyloric stenosis."], "hard_negatives": ["Patients with panic anxiety show decreased CSF levels of hypocretin.", "Antidepressants increase the severity of migraines.", "Hypocretin neurones suppress panicprone state in rats.", "Antidepressants reduce the severity of migraines.", "Headaches are correlated with cognitive impairment.", "Side effects associated with antidepressants increases risk of stroke.", "Exposure to fine particulate air pollution is unrelated to anxiety prevalence.", "In young and middle-aged adults, current or remote uses of ADHD medications increase the risk of serious cardiovascular events.", "Side effects associated with antidepressants lower risk of myocardial infarction.", "Side effects associated with antidepressants do not represent a mortality risk to postmenopausal women."], "hard_negative": "Patients with panic anxiety show decreased CSF levels of hypocretin."}
{"query_id": "933", "query_text": "Pediatric SCD patients with vaso-occlusive crisis show increased morphine use after breathing 80 ppm iNO for 4 hours.", "negative": "Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection increases dissemination of Salmonella Typhimurium from the gut.", "negatives": ["Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection increases dissemination of Salmonella Typhimurium from the gut.", "MFGE8 regulates fat absorption by binding to av-Beta3 and av-Beta5 integrins.", "Gpr124 increases BBB breakdown in mouse models of ischemic stroke.", "Cyclin A2 destruction is necessary to switch from unstable to stable kt-mt attachments in mitosis.", "Incidence of sepsis has fallen substantially from 2009 to 2014.", "Klf4 is not required for proper myeloid cell differentiation.", "The US health care system can save up to $5 billion if 7% of patients waiting for kidney transplants participate in the optimized national kidney paired donation program.", "Decrease of p62 in prostate tumor stroma results in defective autophagy.", "There is no increased risk of hypospadias with clomiphene.", "MafA phosphorylation enhances its ubiquitination."], "hard_negatives": ["Pediatric SCD patients with vaso-occlusive crisis show increased morphine use after breathing 80 ppm iNO for 4 hours.", "Side effects associated with antidepressants lower risk of myocardial infarction.", "Patients with panic anxiety show decreased CSF levels of hypocretin.", "Stroke patients with prior use of direct oral anticoagulants have a higher risk of in-hospital mortality than stroke patients with prior use of warfarin.", "Side effects associated with antidepressants increases risk of stroke.", "High levels of CRP lead to a higher risk of exacerbations in chronic obstructive pulmonary disease (COPD).", "Varenicline monotherapy is more effective after 26 weeks of treatment compared to combination nicotine replacement therapies with varenicline or bupropion.", "In young and middle-aged adults, current or remote uses of ADHD medications increase the risk of serious cardiovascular events.", "Hypocretin neurones suppress panicprone state in rats.", "Combination nicotine replacement therapies with varenicline or bupropion are more effective after 12 weeks of reatment compared to varenicline monotherapy."], "hard_negative": "Pediatric SCD patients with vaso-occlusive crisis show increased morphine use after breathing 80 ppm iNO for 4 hours."}
{"query_id": "934", "query_text": "Perigenital skin is not the primary site of HIV acquisition.", "negative": "Replacement of histone H2A with H2A.Z accelerates gene activation in yeasts by destabilizing +1 nucleosomes.", "negatives": ["Replacement of histone H2A with H2A.Z accelerates gene activation in yeasts by destabilizing +1 nucleosomes.", "VgrG (Tssl) protein punctures membranes by forming a spike at the tip of the tube apparatus.", "Exercise reduces cancer mortality rates among Chinese citizens.", "Low nucleosome occupancy correlates with high methylation levels across species.", "Bariatric surgery leads to negative outcomes in mental health.", "Venules have less significant tunica adventitia than arterioles.", "Bariatric surgery reduces colorectal cancer.", "A deficiency of vitamin B6 decreases blood levels of homocysteine.", "Pro-inflammatory cytokines are up regulated during tumor development.", "The risk of cancer rises with level of alcohol consumption."], "hard_negatives": ["Perigenital skin is not the primary site of HIV acquisition.", "A low percentage of hematopoietic progenitor cells are susceptible to HIV-1 infection ex vivo.", "ART has no effect on the infectiveness of HIV-positive people.", "ART substantially reduces infectiveness of HIV-positive people.", "Urbanization is an important risk factor related to the transmission of dengue fever.", "Chronic HIV stimulation of B cells leads to the premature exhaustion of B cells.", "The HSV-2 infection is typically asymptomatic.", "Patients in stable partnerships have a slower progression from HIV to AIDS.", "Repressing IL-18 has negative effects on atherosclerotic lesion composition and progression.", "Chlamydia trachomatis is most prevalent in the UK among sexually-experienced individuals aged 16 to 24."], "hard_negative": "Perigenital skin is not the primary site of HIV acquisition."}
{"query_id": "935", "query_text": "Peroxynitrite is required for induction of T cell tolerance.", "negative": "Rising temperatures caused by global warming lowers the risk of dengue fever transmission.", "negatives": ["Rising temperatures caused by global warming lowers the risk of dengue fever transmission.", "Higher plasma levels of I-carnitine, when associated with trimethylamine N-oxide, are negatively correlated with cardiovascular events in humans.", "Human embryonic stem cells give rise to cell types from all three embryonic germ layers.", "61% of colorectal cancer patients are diagnosed with regional or distant metastases.", "Misunderstandings between doctors and patients can lead to non-adherence.", "Including pharmacists in rounding teams reduces the incidence of adverse drug events (ADEs).", "ATF4 is a general endoplasmic reticulum stress marker.", "Cis-acting lncRNAs control the expression of genes that are positioned in the vicinity of their transcription sites.", "Diabetes remission occurs less in people treated with conventional therapy than in people treated with laparoscopic adjustable gastric banding surgery.", "Aged patients are more susceptible to ischaemia/reperfusion injury."], "hard_negatives": ["Peroxynitrite is required for induction of T cell tolerance.", "Major antigen-induced signals from the T cell receptor and secondary signals from costimulatory receptors are required for T cell activation.", "CD28 initiates tonic signaling in conventional T cells, which causes an exhaustion phenotype and limited efficiency.", "IL-10 production by monocytes inhibits CD4 + T cell response.", "Type 1 Diabetes is associated with subtle perturbations in T reg development.", "ITAM phosphorylation allows for the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).", "CD28 signals regulate trafficking of murine auto-reactive T cells into target tissues.", "Reduced responsiveness to interleukin-2 in regulatory T cells is associated with autoimmune diseases such as Type 1 Diabetes.", "T cell receptor /CD3 microdomains are required to induce the immunologic synapse.", "Egr2 regulates the homeostasis of B and T cells."], "hard_negative": "Peroxynitrite is required for induction of T cell tolerance."}
{"query_id": "938", "query_text": "Persister cells provide relapse resistance in cancer patients.", "negative": "Low expression of miR7a does not repress target genes or exert a biological function in testis.", "negatives": ["Low expression of miR7a does not repress target genes or exert a biological function in testis.", "Dscam1 acts as a hypervariable pattern-recognition receptor for the immune system.", "Primary cervical cancer screening with HPV detection has lower longitudinal sensitivity than conventional cytology to detect cervical intraepithelial neoplasia grade 2.", "Ca2+ cycling controls whole-body energy homeostasis in beige fat.", "Sudden death can occur in patients with complex ventricular arrhythmias.", "DUSP4 decreases apoptosis.", "Increased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm.", "Bone marrow cells don't contribute to adult macrophage compartments.", "Blocking the interaction between TDP-43 and respiratory complex I proteins ND3 and ND6 prevents TDP-43-induced neuronal loss.", "Neutrophil extracellular trap (NET) antigens may contain the targeted autoantigens PR3 and MPO."], "hard_negatives": ["Persister cells provide relapse resistance in cancer patients.", "Persistor cells are one reason for incomplete responses to Tyrosine kinase inhibitor (TKI) therapy in cancer patients.", "Cancer-associated fibroblasts (CAFs) have no known interaction with cancer cells in the formation and activation of CAFs.", "Cancer-associated fibroblasts (CAFs) interact with cancer cells to mediate formation and activation of CAFs.", "Up-regulation of the p53 pathway and related molecular events speeds cancer progression.", "Cancer-associated fibroblasts (CAFs) are constituents of tumor microenvironments", "Cancer cells can stimulate the accumulation of intra-tumoural myeloid-derived suppressor cells by promoting granulocyte colony stimulating factor production.", "Cancers that initially benefit from epidermal growth factor receptor targeted therapies later become refractory through several mechanisms.", "MEK inhibitors are effective treatments in RAS-driven mouse models of cancer.", "In breast cancer, the loss of myoepithelial cells promotes the transition of ductal carcinoma in situ to invasive carcinoma."], "hard_negative": "Persister cells provide relapse resistance in cancer patients."}
{"query_id": "939", "query_text": "Persistor cells are one reason for incomplete responses to Tyrosine kinase inhibitor (TKI) therapy in cancer patients.", "negative": "CD28 signals regulate trafficking of murine auto-reactive T cells into target tissues.", "negatives": ["CD28 signals regulate trafficking of murine auto-reactive T cells into target tissues.", "Ca2+ cycling is a UCP1-independent thermogenic mechanism.", "Genomic aberrations of metastases provide information for targeted therapy.", "Increased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm.", "Noninvasive positive pressure ventilation is not predictive of acute respiratory failure after solid organ transplantation.", "Tuberculosis incidence occurs at higher rates in more sparsely populated areas in the UK.", "N348I mutations reduce resistance to nevirapine.", "The Snf1 complex regulates carbon and energy metabolism in baker's yeast (Saccharomyces cerevisiae).", "Chenodeoxycholic acid treatment increases brown adipose tissue activity.", "Klf4 is important for proper myeloid cell differentiation."], "hard_negatives": ["Persistor cells are one reason for incomplete responses to Tyrosine kinase inhibitor (TKI) therapy in cancer patients.", "Persister cells provide relapse resistance in cancer patients.", "MEK inhibitors are effective treatments in RAS-driven mouse models of cancer.", "CD28 initiates tonic signaling in conventional T cells, which causes an exhaustion phenotype and limited efficiency.", "In breast cancer, the loss of myoepithelial cells promotes the transition of ductal carcinoma in situ to invasive carcinoma.", "In breast cancer, the loss of myoepithelial cells slows the transition of ductal carcinoma in situ to invasive carcinoma.", "Cancer-associated fibroblasts (CAFs) have no known interaction with cancer cells in the formation and activation of CAFs.", "In melanoma, anti-CTLA-4 treatment reinvigorates exhausted PD-1+Eomes+CD8 T cells.", "Deletion of ATM and Rad3 related protein is not predictive of acute tissue loss.", "90% of patients with melanoma and an objective response to PD-1 blockade will experience a progression in their melanoma."], "hard_negative": "Persistor cells are one reason for incomplete responses to Tyrosine kinase inhibitor (TKI) therapy in cancer patients."}
{"query_id": "940", "query_text": "Pharmacist attendance at ward rounds increases adverse events in wards.", "negative": "A deficiency of folate increases blood levels of homocysteine.", "negatives": ["A deficiency of folate increases blood levels of homocysteine.", "During the primary early antibody response activated B cells migrate toward the inner-and outer follicular areas where oxysterol accumulation is generated by stromal cells.", "Origin gross domestic product(GDP) is positively related to dengue virus (DENV-1) diffusion in air traffic shipments.", "Less than 10% of patients exposed to radiation have activated markers of mesenchymal stem cells.", "0-dimensional biomaterials lack inductive properties.", "There is no increased risk of hypospadias with clomiphene.", "Glucose restriction to 0.05% reduces RLS (replicative life span) by 20-40% in S. cerevisiae.", "ART substantially reduces infectiveness of HIV-positive people.", "miR-142-5P is a known regulator of raised body temperature.", "Cellular clocks are not predictive of mitosis timing in NIH 3T3 cells."], "hard_negatives": ["Pharmacist attendance at ward rounds increases adverse events in wards.", "Pharmacist attendance at ward rounds reduces adverse events in wards.", "Including pharmacists in rounding teams does not alter the incidence of adverse drug events (ADEs).", "Including pharmacists in rounding teams reduces the incidence of adverse drug events (ADEs).", "In young and middle-aged adults, current or remote uses of ADHD medications increase the risk of serious cardiovascular events.", "Cost effectiveness evaluations based on cRCT data accurately reflect prices for patients in actual clinical practice.", "Risk of cardiovascular events can be cut by a third by using antihypertensive drug therapy among hemodialysis patients.", "Side effects associated with antidepressants lower risk of myocardial infarction.", "Assessing treatment adherence is more beneficial to clinical practice than measuring routine outcomes.", "Measuring routine outcomes is more beneficial to clinical practice than assessing treatment adherence."], "hard_negative": "Pharmacist attendance at ward rounds increases adverse events in wards."}
{"query_id": "941", "query_text": "Pharmacist attendance at ward rounds reduces adverse events in wards.", "negative": "Radioiodine treatment of non-toxic multinodular goitre increases thyroid volume.", "negatives": ["Radioiodine treatment of non-toxic multinodular goitre increases thyroid volume.", "Antidepressants reduce the severity of migraines.", "VgrG (Tssl) protein punctures membranes by forming a spike at the tip of the tube apparatus.", "H4 G94P proteins inhibit chromatin assembly, which decreases free histones.", "Ribosome-inactivating protein-2 (RIP-2) interacts with the p75 NTR death domain", "Walking in traffic areas in London did not improve lung function in elderly adults.", "miRNAs regulate a unique suite of mRNAs to maintain homeostasis in cells.", "Adult tissue-resident macrophages are seeded before birth.", "Vitamin D is an important factor in the relationship between calcium and parathyroid hormone.", "Phase information is useful for predicting donor-recipient matches in organ transplantation."], "hard_negatives": ["Pharmacist attendance at ward rounds reduces adverse events in wards.", "Pharmacist attendance at ward rounds increases adverse events in wards.", "Including pharmacists in rounding teams does not alter the incidence of adverse drug events (ADEs).", "Including pharmacists in rounding teams reduces the incidence of adverse drug events (ADEs).", "Cost effectiveness evaluations based on cRCT data accurately reflect prices for patients in actual clinical practice.", "In young and middle-aged adults, current or remote uses of ADHD medications increase the risk of serious cardiovascular events.", "Risk of cardiovascular events can be cut by a third by using antihypertensive drug therapy among hemodialysis patients.", "Assessing treatment adherence is more beneficial to clinical practice than measuring routine outcomes.", "Measuring routine outcomes is more beneficial to clinical practice than assessing treatment adherence.", "Side effects associated with antidepressants lower risk of myocardial infarction."], "hard_negative": "Pharmacist attendance at ward rounds reduces adverse events in wards."}
{"query_id": "942", "query_text": "Phase information is useful for predicting donor-recipient matches in organ transplantation.", "negative": "Therapeutics receiving accelerated approval encounter a lower frequency of post-marketing safety events", "negatives": ["Therapeutics receiving accelerated approval encounter a lower frequency of post-marketing safety events", "4-PBA treatment decreases endoplasmic reticulum stress in response to general endoplasmic reticulum stress markers.", "LRBA promotes CTLA - 4 recycling.", "Cost effectiveness evaluations based on cRCT data lack external validity.", "In rhesus macaques, daily subcutaneous injections of emtricitabine are ineffective at protecting against rectally transmitted simian-human immunodeficiency virus.", "Amitriptyline is an effective treatment for chronic tension-type headaches.", "Pyridostatin prevents double-strand breaks accumulation.", "Tonic signaling from the scFv prevents constitutive stimulation.", "The RANK-RANK-Ligand (RANKL) pathway is involved in the development of Aire-expressing medullary thymic epithelial cells (mTECs).", "Mice defective for deoxyribonucleic acid (DNA) polymerase m (polm) fail to reveal increased sensitivity to ionizing radiation (IR)."], "hard_negatives": ["Phase information is useful for predicting donor-recipient matches in organ transplantation.", "Long - range chromatin interactions regulate transcription.", "Cellular clocks are not predictive of mitosis timing in NIH 3T3 cells.", "Sudden death can occur in patients with complex ventricular arrhythmias.", "The composition of myosin-II isoform switches from the A isoform to the B isoform during hematopoietic differentiation.", "Cellular clocks are associated with mitosis timing in NIH 3T3 cells.", "Genomic aberrations of metastases provide information for targeted therapy.", "Ultrasound guidance significantly reduces the number of needle insertion attempts necessary for a given procedure.", "Noninvasive positive pressure ventilation is not predictive of acute respiratory failure after solid organ transplantation.", "Major antigen-induced signals from the T cell receptor and secondary signals from costimulatory receptors are required for T cell activation."], "hard_negative": "Phase information is useful for predicting donor-recipient matches in organ transplantation."}
{"query_id": "944", "query_text": "Physical activity does not improve cognitive function in individuals with Alzheimers.", "negative": "Repressing IL-18 has negative effects on atherosclerotic lesion composition and progression.", "negatives": ["Repressing IL-18 has negative effects on atherosclerotic lesion composition and progression.", "Mice defective for deoxyribonucleic acid (DNA) polymerase m (polm) reveal increased sensitivity to ionizing radiation (IR).", "MT binding domain drives amyloid structure formation.", "Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 encourage West Nile virus replication in cortical neurons.", "Ethanol stress increases the expression of SRL in bacteria.", "RA activation of DIF2 and NB4 cells induces hallmarks of transcriptionally active promoters.", "Urbanization is an important risk factor related to the transmission of dengue fever.", "The US health care system can save up to $5 billion if 7% of patients waiting for kidney transplants participate in the optimized national kidney paired donation program.", "Deletion of ATM and Rad3 related protein leads to acute tissue loss.", "Sympathetic nerve activity is elevated throughout normal pregnancy."], "hard_negatives": ["Physical activity does not improve cognitive function in individuals with Alzheimers.", "Individuals with Alzheimers who participate in six months of physical activity improve cognitive function for up to 18 months.", "Headaches are correlated with cognitive impairment.", "Asymptomatic visual impairment screening in elderly populations leads to improved vision.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have increased risk for Alzheimer's disease.", "In young and middle-aged adults, current or remote uses of ADHD medications increase the risk of serious cardiovascular events.", "Incidence of 10/66 dementia is lower than the incidence of DSM-IV dementia.", "Incidence of 10/66 dementia is higher than the incidence of DSM-IV dementia.", "Medications to treat obesity do not have side effects.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have decreased risk for dementia."], "hard_negative": "Physical activity does not improve cognitive function in individuals with Alzheimers."}
{"query_id": "945", "query_text": "Physical activity level has no association with the difference in maximal oxygen consumption between black and white youth.", "negative": "Low nucleosome occupancy correlates with high methylation levels across species.", "negatives": ["Low nucleosome occupancy correlates with high methylation levels across species.", "Bariatric surgery reduces colorectal cancer.", "Having a main partner improves HIV outcomes.", "Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission.", "Cancer-associated fibroblasts (CAFs) have no known interaction with cancer cells in the formation and activation of CAFs.", "Charcoal shows no benefit for acute paraquat poisoning.", "Beta-band coherence is enhanced for visible stimuli over invisible stimuli.", "Obesity decreases life quality.", "RUNX is not expressed in skin tissue.", "The DEXI promoter region is bound by multiple transcription factors in a murine haematopoietic progenitor cell line."], "hard_negatives": ["Physical activity level has no association with the difference in maximal oxygen consumption between black and white youth.", "Physical activity level is associated with the difference in maximal oxygen consumption between black and white youth.", "The morphology change from large white adipocytes to small brown adipocytes is a sign of decreased energy expenditure potential in white adipose tissue.", "The morphology change from large white adipocytes to small brown adipocytes is a sign of increased energy expenditure potential in white adipose tissue.", "Participants who quit smoking reduce lung cancer risk by approximately 50%.", "Walking in traffic areas in London did not improve lung function in elderly adults.", "Walking in traffic areas in London improves lung function in elderly adults.", "Hypothalamic glutamate neurotransmission is unrelated to energy balance.", "Excess gestational weight gain is associated with obesity-related pregnancy outcomes.", "Energy balance requires hypothalamic glutamate neurotransmission."], "hard_negative": "Physical activity level has no association with the difference in maximal oxygen consumption between black and white youth."}
{"query_id": "946", "query_text": "Physical activity level is associated with the difference in maximal oxygen consumption between black and white youth.", "negative": "For every 1,000 children with cerebral palsy, more than 300 of them are premature or underweight at birth.", "negatives": ["For every 1,000 children with cerebral palsy, more than 300 of them are premature or underweight at birth.", "Participants who quit smoking reduce lung cancer risk by approximately 50%.", "Mutations in RIM1 decrease levels of IME1 RNA.", "\u03b21/Ketel is able to bind microtubules.", "Antimicrobial agents are more effective due to the pressure of antimicrobial usage.", "NR5A2 is important in reverse cholesterol transport in humans.", "Pyridostatin induces double-strand breaks accumulation.", "Stiff substrates inhibit mesodermal differentiation by degrading beta-catenin in an integrin-dependent manner.", "Measuring routine outcomes is more beneficial to clinical practice than assessing treatment adherence.", "HbA1c consistently overestimates glycemic control in black individuals with Sickle cell trait (SCT)."], "hard_negatives": ["Physical activity level is associated with the difference in maximal oxygen consumption between black and white youth.", "Physical activity level has no association with the difference in maximal oxygen consumption between black and white youth.", "The morphology change from large white adipocytes to small brown adipocytes is a sign of increased energy expenditure potential in white adipose tissue.", "The morphology change from large white adipocytes to small brown adipocytes is a sign of decreased energy expenditure potential in white adipose tissue.", "Walking in traffic areas in London improves lung function in elderly adults.", "Participants who quit smoking reduce lung cancer risk by approximately 50%.", "Energy balance requires hypothalamic glutamate neurotransmission.", "Hypothalamic glutamate neurotransmission is unrelated to energy balance.", "Walking in traffic areas in London did not improve lung function in elderly adults.", "Exposure to fine particulate air pollution is unrelated to anxiety prevalence."], "hard_negative": "Physical activity level is associated with the difference in maximal oxygen consumption between black and white youth."}
{"query_id": "949", "query_text": "Physical injury represses transgultaminase activity.", "negative": "Chinese individuals with TT homozygosity in the MTHFR gene are more vulnerable to strokes caused by low levels of folate intake.", "negatives": ["Chinese individuals with TT homozygosity in the MTHFR gene are more vulnerable to strokes caused by low levels of folate intake.", "Cardiac tissue-resident macrophages directly contribute to electrical activity.", "In pediatric tissue, most T cells are naive T cell emigrants from the thymus.", "Deltex interacts with eIF3. There is no known interaction between Deltex and elF3", "Microglia are an innate immune cell type of the central nervous system.", "Emodin forms hydrogen bonds with residues involved in PGAM1 substrate binding.", "Walking in traffic areas in London did not improve lung function in elderly adults.", "DUSP4 increases apoptosis.", "Replacement of histone H2A with H2A.Z accelerates gene activation in yeasts by destabilizing +1 nucleosomes.", "p16INK4A degradation is  linked to an abnormal wound response caused by the microinvasive step of advanced Oral Potentially Malignant Lesions (OPMLs)."], "hard_negatives": ["Physical injury represses transgultaminase activity.", "Chemical injury represses transglutaminase 2 activity.", "Neutrophils produce IL-1\u03b2 in response to large particles.", "Side effects associated with antidepressants increases risk of stroke.", "Autophagy deficiency in the liver increases vulnerability to insulin resistance.", "Oxidative phosphorylation is one of the primary glycometabolic pathways in cells.", "Intramembrane cleavage by signal peptide peptidase aids in the degradation of proteins with a complex membrane orientation.", "Activated Cdk5 regulates DNA damage-induced neuronal death.", "Reduced levels of lipolysis leads to higher P38 phosphorylation in adipose tissue.", "Formation of N-terminal pyroglutamate by glutamine cyclase (GC) competes with NTAQ1 for Nt-Gln substrates."], "hard_negative": "Physical injury represses transgultaminase activity."}
{"query_id": "951", "query_text": "Piezo1 channels are sensors for cell migration in epithelial cells.", "negative": "PrimPol degrades short DNA replication intermediates on the leading strand during DNA replication.", "negatives": ["PrimPol degrades short DNA replication intermediates on the leading strand during DNA replication.", "Insulin effects appetite via ventral tegmental neurons.", "There is no known interaction between Pioneer factor OCT3/4 and major chromatin remodeling factors.", "Oxidative DNA damage activates STING signalling.", "Physical injury represses transgultaminase activity.", "Distant CREs are important for transcriptional regulation.", "Consumption of whole fruits increases the risk of type 2 diabetes.", "The Snf1 complex regulates carbon and energy metabolism in baker's yeast (Saccharomyces cerevisiae).", "Higher plasma levels of I-carnitine, when associated with trimethylamine N-oxide, are positively correlated with cardiovascular events in humans.", "Increased conversion of PGE 2 to PPARy ligand 15-ket-PGE 2 causes accumulation of PGE."], "hard_negatives": ["Piezo1 channels are sensors for cell migration in epithelial cells.", "MeCP2 influences the synaptic maturation of neurons.", "Differentiation of progenitor cells to myeloid cells is skewed upon activation of insulin signaling.", "Intramembrane cleavage by signal peptide peptidase aids in the degradation of proteins with a complex membrane orientation.", "Forkhead 0 (fox0) transcription factors are involved in cellular differentiation.", "Myelin sheaths are lipid-rich cellular structures.", "VgrG (Tssl) protein punctures membranes by forming a spike at the tip of the tube apparatus.", "TMEM27 is a marker for beta cells.", "Differentiation of progenitor cells to myeloid cells is skewed when insulin signaling is suppressed.", "The cytokine receptor which regulates chemotaxis and formation of lymph nodes is involved in production of myeloperoxidase in the left atrium."], "hard_negative": "Piezo1 channels are sensors for cell migration in epithelial cells."}
{"query_id": "952", "query_text": "Pioglitazone use is not associated with an increased risk of prostate cancer.", "negative": "The minor G allele of FOXO3 up-regulates IL-10.", "negatives": ["The minor G allele of FOXO3 up-regulates IL-10.", "Enhanced early production of inflammatory chemokines damages viral control in the lung.", "Ly49Q directs the organization of neutrophil polarization by regulating membrane raft functions.", "Mitochondria play a major role in energy production.", "Risk of cardiovascular events can be cut by a third by using antihypertensive drug therapy among hemodialysis patients.", "RANK-RANKL pathway signalling has no known association with development of Aire-expressing medullary thymic epithelial cells.", "53% of perinatal mortality is due to low birth weight.", "Upregulation of dynein in Drosophila neurons increases the number of microtubule plus-ends growing toward the cell body of each neuron.", "Inhibiting HDAC6 increases survival of mice with ARID1A mutated tumors.", "H4 G94P proteins induce chromatin assembly, which increases free histones."], "hard_negatives": ["Pioglitazone use is not associated with an increased risk of prostate cancer.", "Pioglitazone use is significantly associated with an increased risk of prostate cancer.", "Pioglitazone use is significantly associated with an increased risk of pancreatic cancer.", "Sildenafil worsens erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.", "Taking 400mg of \u03b1-tocopheryl acetate does not prevent prostate cancer.", "Taking 400mg of \u03b1-tocopheryl acetate in combination with vitamin C reduces the risk of prostate cancer.", "Side effects associated with antidepressants do not represent a mortality risk to postmenopausal women.", "Side effects associated with antidepressants increases risk of stroke.", "A breast cancer patient's capacity to metabolize tamoxifen influences treatment outcome.", "Side effects associated with antidepressants lower risk of myocardial infarction."], "hard_negative": "Pioglitazone use is not associated with an increased risk of prostate cancer."}
{"query_id": "953", "query_text": "Pioglitazone use is significantly associated with an increased risk of pancreatic cancer.", "negative": "The morphology change from large white adipocytes to small brown adipocytes is a sign of increased energy expenditure potential in white adipose tissue.", "negatives": ["The morphology change from large white adipocytes to small brown adipocytes is a sign of increased energy expenditure potential in white adipose tissue.", "Sildenafil worsens erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.", "Deltex interacts with eIF3. There is no known interaction between Deltex and elF3", "Tuberculosis incidence occurs at higher rates in more sparsely populated areas in the UK.", "The PDPN gene deactivates the C-type lectin receptor (CLEC-2).", "Stiff substrates encourage mesodermal differentiation by degrading beta-catenin in an integrin-dependent manner.", "Transcription factor EB induces transcription of pro-inflammatory cytokines in macrophages infected with Staphylococcus aureus.", "Sweet taste receptors on the tongue are deactivated by between 1 and 10 mM glucose.", "Induced hepatic stem cells possess the potential to differentiate into hepatocytic cells.", "YAP/TAZ is required in intestinal regeneration in mouse models of ulcerative colitis."], "hard_negatives": ["Pioglitazone use is significantly associated with an increased risk of pancreatic cancer.", "Pioglitazone use is significantly associated with an increased risk of prostate cancer.", "Pioglitazone use is not associated with an increased risk of prostate cancer.", "A breast cancer patient's capacity to metabolize tamoxifen influences treatment outcome.", "Side effects associated with antidepressants increases risk of stroke.", "Sildenafil worsens erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.", "Side effects associated with antidepressants lower risk of myocardial infarction.", "Side effects associated with antidepressants do not represent a mortality risk to postmenopausal women.", "Taking 400mg of \u03b1-tocopheryl acetate in combination with vitamin C reduces the risk of prostate cancer.", "Taking 400mg of \u03b1-tocopheryl acetate does not prevent prostate cancer."], "hard_negative": "Pioglitazone use is significantly associated with an increased risk of pancreatic cancer."}
{"query_id": "954", "query_text": "Pioglitazone use is significantly associated with an increased risk of prostate cancer.", "negative": "Deltex interacts with eIF3. There is no known interaction between Deltex and elF3", "negatives": ["Deltex interacts with eIF3. There is no known interaction between Deltex and elF3", "r-protein chaperones are found in complexes with their r-protein binding partners.", "90% of patients with melanoma and an objective response to PD-1 blockade will experience a progression in their melanoma.", "The latent infection of myeloid cells with human cytomegalovirus induces a number of changes in gene expression.", "Lamins are found within the inner layer of the nuclear membrane of all cells.", "Deletion of ATM and Rad3 related protein leads to acute tissue loss.", "In chronic viral infections or tumors, peptides that selectively inhibit PTPRS can be utilized to boost insufficient activity of pDCs.", "Patients in stable partnerships have a slower progression from HIV to AIDS.", "Tuberculosis incidence occurs at higher rates in more sparsely populated areas in the UK.", "Mouse models can be generated using \"artificial spermatids.\""], "hard_negatives": ["Pioglitazone use is significantly associated with an increased risk of prostate cancer.", "Pioglitazone use is not associated with an increased risk of prostate cancer.", "Pioglitazone use is significantly associated with an increased risk of pancreatic cancer.", "Sildenafil worsens erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.", "Taking 400mg of \u03b1-tocopheryl acetate in combination with vitamin C reduces the risk of prostate cancer.", "Taking 400mg of \u03b1-tocopheryl acetate does not prevent prostate cancer.", "Side effects associated with antidepressants do not represent a mortality risk to postmenopausal women.", "Side effects associated with antidepressants increases risk of stroke.", "A breast cancer patient's capacity to metabolize tamoxifen influences treatment outcome.", "Side effects associated with antidepressants lower risk of myocardial infarction."], "hard_negative": "Pioglitazone use is significantly associated with an increased risk of prostate cancer."}
{"query_id": "955", "query_text": "Pioneer factor OCT3/4 interacts with major chromatin remodeling factors.", "negative": "Recognition of start codons depends on the translation initiation factor IF3.", "negatives": ["Recognition of start codons depends on the translation initiation factor IF3.", "Decrease of p62 in prostate tumor stroma results in defective autophagy.", "Lmna knock-in models are appropriate for testing therapeutic approaches against Hutchinson-Gilford progeria syndrome (HGPS).", "Glycan adaptation is rarely observed in the B-cell repertoire.", "There is a positive correlation between hip fractures and statin use.", "Physical activity level has no association with the difference in maximal oxygen consumption between black and white youth.", "Increased microtubule acetylation repairs interference of axonal transport caused by LRRK2 Roc-COR domain mutations.", "The latent infection of myeloid cells with human cytomegalovirus induces a number of changes in gene expression.", "Including pharmacists in rounding teams does not alter the incidence of adverse drug events (ADEs).", "BiP is a general endoplasmic reticulum stress marker."], "hard_negatives": ["Pioneer factor OCT3/4 interacts with major chromatin remodeling factors.", "There is no known interaction between Pioneer factor OCT3/4 and major chromatin remodeling factors.", "Bcp1 is a chaperone for Rpl23.", "The predominant localization of Linc00173 is in mononuclear macrophage nuclei.", "Addition of BMP4, activin A, CHIR99021, and SU504 to reprogramming fibroblasts generates, expands and maintains cardiovascular progenitor cells (CPCs)", "The PPR MDA5 has twenty N-terminal CARD domains.", "Genes regulated by Esrrb transcription factor are sensitive to Mbd3 function.", "Fibroblast growth factor 21 protects against atherosclerosis by modulating adiponectin and SREBP2 levels.", "Long - range chromatin interactions regulate transcription.", "CCL19 is predominantly present within dLNs."], "hard_negative": "Pioneer factor OCT3/4 interacts with major chromatin remodeling factors."}
{"query_id": "959", "query_text": "Polymeal nutrition increases cardiovascular mortality.", "negative": "DUSP4 increases apoptosis.", "negatives": ["DUSP4 increases apoptosis.", "Inhibiting glucose-6-phospate dehydrogenase improves lipogenesis by deactivating LKB1-AMPK signaling.", "CD44v6 is not associated with constitutive and reprogrammed cancer stem cells driving cancer metastasis.", "TMEM27 is a marker for beta cells.", "The origin of the CRF01_1b2k protein occurred between 1923 and 1956.", "Healthy volunteers exhibit rapid and transient increase of cellular ATP after being bolus-injected with fructose.", "Helicobacter pylori-induced aberrant NF-kB-dependent expression of activation-induced cytidine deaminase contributes to the mutagenesis of host DNA.", "Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission.", "Converting apoE4 to apoE3 by gene editing prevents the pathology associated with apoE4 in human iPSCderived neurons.", "DUSP4 decreases apoptosis."], "hard_negatives": ["Polymeal nutrition increases cardiovascular mortality.", "Long chain polyunsaturated fatty acids supplementation reduces wheezing and asthma.", "Suboptimal nutrition is a leading cause of premature death", "Moderate consumption of candy and chocolate reduces the risk of cardiovascular disease (CVD).", "LDL cholesterol has a causal role in the development of cardiovascular disease.", "It is not proven that moderate consumption of candy and chocolate reduces the risk of cardiovascular disease (CVD) specifically.", "Long chain polyunsaturated fatty acids supplementation is associated with lower rates of atopic eczema at 1 year.", "Weighed food records (WFR) result in poor completion since they're costly to run and impose high participant burden.", "Consumption of whole fruits increases the risk of type 2 diabetes.", "Weighed food records (WFR) result in high completion since they're cheap to run and impose low participant burden."], "hard_negative": "Polymeal nutrition increases cardiovascular mortality."}
{"query_id": "962", "query_text": "Post-transcriptional handling of mitochondrial transcripts occurs in mitochondrial RNA granules.", "negative": "7-day-old adult Caenorhabditis elegans exhibit approximately 5% of the learning capacity seen in 1-day old adults.", "negatives": ["7-day-old adult Caenorhabditis elegans exhibit approximately 5% of the learning capacity seen in 1-day old adults.", "Tuberculosis-induced granulomas express different immune system protein signatures than the surrounding tissue.", "De novo assembly of sequence data has shorter contigs than unassembled sequence data.", "Forkhead 0 (fox0) transcription factors are involved in cellular differentiation.", "PKG-la does not have a large impact on expression of spinal long term potentiation in PGK-la knockout mice.", "Allogeneic mechanical circulatory support is not as effective as autologous mechanical circulatory support for treating acute myocardial infarction.", "Bacterial meningitis can be diagnosed on the basis of positive cerebrospinal fluid (CSF) cultures.", "Androgenetic haploid mouse embryonic stem cells (ESCs) can be derived and genetically manipulated in vitro.", "Transplanted human glial progenitor cells can mature in their host animal.", "aPKCz causes tumour suppression by affecting glutamine metabolism."], "hard_negatives": ["Post-transcriptional handling of mitochondrial transcripts occurs in mitochondrial RNA granules.", "Lamins are found within the inner layer of the mitochondrial membrane of all cells.", "Genes involved in pre-mRNA splicing have a significant impact on genome stability.", "Pre-mRNAs associated with spliceosomal components are less stable than unassociated splicing substrates.", "Pre-mRNAs associated with spliceosomal components are more stable than unassociated splicing substrates.", "miRNAs regulate a unique suite of mRNAs to maintain homeostasis in cells.", "Cellular differentiation of embryonic stem cells is accompanied by changes in replication timing, transcription and nuclear localization.", "Trans-acting factors, such as lncRNAs, influence mRNA translation.", "miRNAs enforce homeostasis by suppressing low-level ''leaky'' transcription.", "Immune complex triggered cell death leads to sequestration of oxidized mitochondrial DNA."], "hard_negative": "Post-transcriptional handling of mitochondrial transcripts occurs in mitochondrial RNA granules."}
{"query_id": "963", "query_text": "Pre-mRNAs associated with spliceosomal components are less stable than unassociated splicing substrates.", "negative": "There is no increased risk of hypospadias with clomiphene.", "negatives": ["There is no increased risk of hypospadias with clomiphene.", "7-day-old adult Caenorhabditis elegans exhibit approximately 5% of the learning capacity seen in 1-day old adults.", "Exposure to fine particulate air pollution is unrelated to anxiety prevalence.", "Charcoal is an effective treatment for acute paraquat poisoning.", "The innate immune response struggles to remove small numbers of parasites.", "7-day-old adult Caenorhabditis elegans exhibit approximately 5% of the learning capacity seen in 1-day old adults.", "BiP is a general endoplasmic reticulum stress marker.", "A 100g dose of chloroquine chemoprophylactic regimen results in retinal toxicity after 1 year of weekly intake.", "Type 1 Diabetes is associated with subtle perturbations in T reg development.", "Omnivores produce less trimethylamine N-oxide from dietary I-carnitine than vegans."], "hard_negatives": ["Pre-mRNAs associated with spliceosomal components are less stable than unassociated splicing substrates.", "Pre-mRNAs associated with spliceosomal components are more stable than unassociated splicing substrates.", "Genes involved in pre-mRNA splicing have a significant impact on genome stability.", "Pseudoknots are not evolutionarily conserved in most eukaryotes.", "Trans-acting factors, such as lncRNAs, influence mRNA translation.", "miRNAs regulate a unique suite of mRNAs to maintain homeostasis in cells.", "Post-transcriptional handling of mitochondrial transcripts occurs in mitochondrial RNA granules.", "mcm 5 s 2 U is required for proper decoding of NNR codons in eukaryotes.", "r-protein chaperones are found in complexes with their r-protein binding partners.", "IFIT1 speeds viral replication by allowing for the proliferation of mis-capped viral RNAs."], "hard_negative": "Pre-mRNAs associated with spliceosomal components are less stable than unassociated splicing substrates."}
{"query_id": "964", "query_text": "Pre-mRNAs associated with spliceosomal components are more stable than unassociated splicing substrates.", "negative": "MFGE8 regulates fat absorption by binding to av-Beta3 and av-Beta5 integrins.", "negatives": ["MFGE8 regulates fat absorption by binding to av-Beta3 and av-Beta5 integrins.", "Chenodeoxycholic acid treatment increases brown adipose tissue activity.", "The repeat-variable diresidue (RVD) in the loop of Transcription-Activator Like (TAL) effectors specifies the nucleotides-amino acid contact at the target promoter element.", "Cnn1 recruitment varies with cell cycle timing.", "Sequence conservation in gene regulatory regions between species is a poor predictor of conserved functionality.", "The TRaF1/C5 rs10818488 allele polymorphism regulates the neighboring C5 gene.", "ScPif1p has reduced binding ability to G-rich ssDNA compared to non-G-rich ssDNA.", "Women with a lower birth weight are more likely to develop breast cancer later in life.", "HAND2 methylation is a key step in early endometrial carcinogenesis.", "Having a main partner improves HIV outcomes."], "hard_negatives": ["Pre-mRNAs associated with spliceosomal components are less stable than unassociated splicing substrates.", "Pre-mRNAs associated with spliceosomal components are more stable than unassociated splicing substrates.", "Genes involved in pre-mRNA splicing have a significant impact on genome stability.", "Pseudoknots are not evolutionarily conserved in most eukaryotes.", "Trans-acting factors, such as lncRNAs, influence mRNA translation.", "miRNAs regulate a unique suite of mRNAs to maintain homeostasis in cells.", "Post-transcriptional handling of mitochondrial transcripts occurs in mitochondrial RNA granules.", "r-protein chaperones are found in complexes with their r-protein binding partners.", "IFIT1 speeds viral replication by allowing for the proliferation of mis-capped viral RNAs.", "mcm 5 s 2 U is required for proper decoding of NNR codons in eukaryotes."], "hard_negative": "Pre-mRNAs associated with spliceosomal components are less stable than unassociated splicing substrates."}
{"query_id": "965", "query_text": "Prescribed exercise training improves quality of life.", "negative": "Headaches are correlated with cognitive impairment.", "negatives": ["Headaches are correlated with cognitive impairment.", "Bariatric surgery increases rates of colorectal cancer.", "Klf4 is important for proper myeloid cell differentiation.", "During non-homologous end joining, the ligation step is not as tolerant of disrepairs and other distortions when joining 5' of strand breaks as compared to 3' strand breaks.", "The mean suicide rate in women is higher after miscarriage than live birth.", "Algerian physicians constitue the largest component of sub-Saharan Africa-trained physicians in the United States.", "B cells go though plasmablast differentiation and antibody production by continuous expression of EBI2.", "EG7 tumors can be killed by systemic oxaliplatin primed CD8+ T cells from the tumor-draining lymph node cells.", "Toll-like receptor (TLR) signaling is involved in the pathogenesis of human MDS.", "Hematopoietic Stem Cell purification reaches purity rates above 90%."], "hard_negatives": ["Prescribed exercise training improves quality of life.", "Obesity raises life quality.", "Exercise increases cancer mortality rates among Chinese citizens.", "Obesity decreases life quality.", "Exercise reduces cancer mortality rates among Chinese citizens.", "Measuring routine outcomes is more beneficial to clinical practice than assessing treatment adherence.", "Assessing treatment adherence is more beneficial to clinical practice than measuring routine outcomes.", "General exercise therapy is more effective than rotator cuff exercises in reducing pain and improving function of the shoulder.", "General exercise therapy is more effective than scapular stabilizer exercises in reducing pain and improving function of the shoulder.", "Insulin decreases risk of severe kidney failure."], "hard_negative": "Prescribed exercise training improves quality of life."}
{"query_id": "969", "query_text": "PrimPol degrades short DNA replication intermediates on the leading strand during DNA replication.", "negative": "Elevated cell-free mitochondrial DNA levels are associated with mortality.", "negatives": ["Elevated cell-free mitochondrial DNA levels are associated with mortality.", "The NF-\u03baB essential modulator gene induces intestinal inflammation by promoting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death.", "Less than 10% of patients exposed to radiation have activated markers of mesenchymal stem cells.", "Major antigen-induced signals from the T cell receptor and secondary signals from costimulatory receptors are required for T cell activation.", "Medications to treat obesity have unwanted side effects.", "HNF4A mutations are associated with macrosomia in infancy.", "Activation of the Rac1 homolog CED-10 kills viable cells in SRGP-1 mutant Caenorhabditis elegans.", "Rotator cuff exercises are more effective than general exercise therapy in reducing pain and improving function of the shoulder.", "Binding of p53 to enhancer regions (p53BERs) regulates the activity of p53 transcription and cell cycle arrest through the production of p53-dependent eRNAs.", "NR5A2 is important in reverse cholesterol transport in humans."], "hard_negatives": ["PrimPol degrades short DNA replication intermediates on the leading strand during DNA replication.", "PrimPol generates short DNA replication intermediates on the leading strand during DNA replication.", "Mice defective for deoxyribonucleic acid (DNA) polymerase m (polm) fail to reveal increased sensitivity to ionizing radiation (IR).", "Mice defective for deoxyribonucleic acid (DNA) polymerase I (polI) fail to reveal increased sensitivity to ionizing radiation (IR).", "Mice defective for deoxyribonucleic acid (DNA) polymerase m (polm) reveal increased sensitivity to ionizing radiation (IR).", "Clathrin stabilizes the spindle fiber apparatus during mitosis.", "MafA phosphorylation decreases its ubiquitination.", "R2D2 stops miRNA production by increasing the selectivity of Dcr2 for long dsRNA.", "MafA phosphorylation enhances its ubiquitination.", "MafA ubiquitination increases the recruitment of coavtivator P/CAF by MafA."], "hard_negative": "PrimPol degrades short DNA replication intermediates on the leading strand during DNA replication."}
{"query_id": "970", "query_text": "PrimPol generates short DNA replication intermediates on the leading strand during DNA replication.", "negative": "Combination nicotine replacement therapies with varenicline or bupropion are more effective after 12 weeks of reatment compared to varenicline monotherapy.", "negatives": ["Combination nicotine replacement therapies with varenicline or bupropion are more effective after 12 weeks of reatment compared to varenicline monotherapy.", "Increased microtubule acetylation exacerbates LRRK2 Roc-COR domain mutation induced locomotor deficits.", "Lice attenuated SIV vaccines induce a stronger antigen-specific T cell response in lymph node cells.", "Transcription factor EB induces transcription of pro-inflammatory cytokines in macrophages infected with Staphylococcus aureus.", "Transplanted human glial progenitor cells can mature in their host animal.", "There is no association between HNF4A mutations and diabetes risks.", "7-day-old adult Caenorhabditis elegans exhibit approximately 75% of the learning capacity seen in 1-day old adults.", "BLM gene encodes RecQ-class DNA helicase.", "Prescribed exercise training improves quality of life.", "A 100g dose of chloroquine chemoprophylactic regimen results in retinal toxicity after 5-6 years of weekly intake."], "hard_negatives": ["PrimPol generates short DNA replication intermediates on the leading strand during DNA replication.", "PrimPol degrades short DNA replication intermediates on the leading strand during DNA replication.", "Mice defective for deoxyribonucleic acid (DNA) polymerase m (polm) fail to reveal increased sensitivity to ionizing radiation (IR).", "Clathrin stabilizes the spindle fiber apparatus during mitosis.", "Mice defective for deoxyribonucleic acid (DNA) polymerase m (polm) reveal increased sensitivity to ionizing radiation (IR).", "Mice defective for deoxyribonucleic acid (DNA) polymerase I (polI) fail to reveal increased sensitivity to ionizing radiation (IR).", "MafA phosphorylation enhances its ubiquitination.", "Emodin forms hydrogen bonds with residues involved in PGAM1 substrate binding.", "MafA phosphorylation decreases its ubiquitination.", "RAD52 is involved in break-induced DNA replication (BIR)."], "hard_negative": "PrimPol generates short DNA replication intermediates on the leading strand during DNA replication."}
{"query_id": "972", "query_text": "Primary cervical cancer screening with HPV detection has lower longitudinal sensitivity than conventional cytology to detect cervical intraepithelial neoplasia grade 2.", "negative": "Microglia are an innate immune cell type of the peripheral nervous system.", "negatives": ["Microglia are an innate immune cell type of the peripheral nervous system.", "A 100g dose of chloroquine chemoprophylactic regimen results in retinal toxicity after 1 year of weekly intake.", "The NF-\u03baB essential modulator gene induces intestinal inflammation by promoting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death.", "Tirasemtiv has no effect on cardiac muscle.", "Intake of folic acid (FA) and vitamin B6 (VB6) reduces levels of homocysteine.", "Gastric infection with Helicobacter pylori decreases risk of gastric cancer in humans.", "In the UK, drowning affects boys and girls equally.", "Chemical injury represses transglutaminase 2 activity.", "Students who perform poorly in the early years of medical school are at increased risk for professional misconduct later in their careers.", "Broadly HIV-1 Neutralizing Antibodies (bnAb) 10EB have no affinity for phospholipids."], "hard_negatives": ["Primary cervical cancer screening with HPV detection has lower longitudinal sensitivity than conventional cytology to detect cervical intraepithelial neoplasia grade 2.", "Primary cervical cytology screening with HPV detection has higher longitudinal sensitivity to detect severe cervical intraepithelial neoplasia than conventional cytology.", "The risk of breast cancer among parous women decreases with placental weight of pregnancies.", "In breast cancer, the loss of myoepithelial cells slows the transition of ductal carcinoma in situ to invasive carcinoma.", "In breast cancer, the loss of myoepithelial cells promotes the transition of ductal carcinoma in situ to invasive carcinoma.", "1-1% of colorectal cancer patients are diagnosed with regional or distant metastases.", "61% of colorectal cancer patients are diagnosed with regional or distant metastases.", "Women with a lower birth weight are more likely to develop breast cancer later in life.", "BRCA 1 mutation carriers' risk of breast and ovarian cancer depends on where the mutation is located.", "CD44v6 is not associated with constitutive and reprogrammed cancer stem cells driving cancer metastasis."], "hard_negative": "Primary cervical cancer screening with HPV detection has lower longitudinal sensitivity than conventional cytology to detect cervical intraepithelial neoplasia grade 2."}
{"query_id": "973", "query_text": "Primary cervical cytology screening with HPV detection has higher longitudinal sensitivity to detect severe cervical intraepithelial neoplasia than conventional cytology.", "negative": "BCL-2 promotes the apoptotic effects of c-Myc.", "negatives": ["BCL-2 promotes the apoptotic effects of c-Myc.", "In rhesus macaques, daily subcutaneous injections of emtricitabine are ineffective at protecting against rectally transmitted simian-human immunodeficiency virus.", "The repeat-variable diresidue (RVD) in the loop of Transcription-Activator Like (TAL) effectors specifies the nucleotides-amino acid contact at the target promoter element.", "Rhythmic expression of Cry1 translates directly into a circadian regulation of cAMP signaling in gluconeogenesis.", "MafA phosphorylation decreases its ubiquitination.", "Incidence of heart failure increased by 10% in women since 1979.", "Repressing IL-18 has negative effects on atherosclerotic lesion composition and progression.", "Tonic signaling from the scFv prevents constitutive stimulation.", "HbA1c consistently overestimates glycemic control in black individuals with Sickle cell trait (SCT).", "Normal granulomas form in the presence of TNF in Zebrafish."], "hard_negatives": ["Primary cervical cytology screening with HPV detection has higher longitudinal sensitivity to detect severe cervical intraepithelial neoplasia than conventional cytology.", "Primary cervical cancer screening with HPV detection has lower longitudinal sensitivity than conventional cytology to detect cervical intraepithelial neoplasia grade 2.", "Ultrasound guidance significantly reduces the number of traumatic procedures when attempting needle insertion.", "CRP is positively correlated with postoperative mortality following Coronary Artery Bypass Graft (CABG) surgery.", "Ultrasound guidance significantly reduces the number of needle insertion attempts necessary for a given procedure.", "The combination of physical examinations with C-reactive protein values do not improve the accuracy of radiographic verified pneumonia predictions.", "High levels of CRP lead to a higher risk of exacerbations in chronic obstructive pulmonary disease (COPD).", "The risk of breast cancer among parous women decreases with placental weight of pregnancies.", "In breast cancer, the loss of myoepithelial cells promotes the transition of ductal carcinoma in situ to invasive carcinoma.", "In breast cancer, the loss of myoepithelial cells slows the transition of ductal carcinoma in situ to invasive carcinoma."], "hard_negative": "Primary cervical cytology screening with HPV detection has higher longitudinal sensitivity to detect severe cervical intraepithelial neoplasia than conventional cytology."}
{"query_id": "976", "query_text": "Primary pro-inflammatory cytokines suppress secondary pro- and anti-inflammatory mediators.", "negative": "Ethanol stress increases the expression of IBP in bacteria.", "negatives": ["Ethanol stress increases the expression of IBP in bacteria.", "ATM and Rad3 related protein have no role in sensing DNA damage.", "90% of patients with melanoma and an objective response to PD-1 blockade will experience a progression in their melanoma.", "Pharmacist attendance at ward rounds increases adverse events in wards.", "LRBA prevents CTLA - 4 recycling.", "There is no relation between Erythromycin use and hypertrophic pyloric stenosis.", "Most termination events in Okazaki fragments are dictated by initiation patterns.", "Bariatric surgery reduces colorectal cancer.", "Increased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm.", "7-day-old adult Caenorhabditis elegans exhibit approximately 5% of the learning capacity seen in 1-day old adults."], "hard_negatives": ["Primary pro-inflammatory cytokines suppress secondary pro- and anti-inflammatory mediators.", "Pro-inflammatory cytokines are up regulated during tumor development.", "Tumor development occurs in conjunction with upregulation of pro-inflammatory cytokines.", "Many cytokines that are produced by cancer cells also contribute to carcinogenesis.", "Pro-inflammatory cytokines are up repressed during tumor development.", "Tumor development occurs in conjunction with suppression of pro-inflammatory cytokines.", "Cholesterol loading induces KLF4 expression in VSMCs, resulting in the expression of pro-inflammatory cytokines.", "The density of cytokine receptor bearing cells affects the distance over which cytokines act.", "The density of cytokine receptor bearing cells has no effect on the distance over which cytokines act.", "The minor G allele of FOXO3 downregulates pro-inflammatory cytokines."], "hard_negative": "Primary pro-inflammatory cytokines suppress secondary pro- and anti-inflammatory mediators."}
{"query_id": "977", "query_text": "Pro-inflammatory cytokines are up regulated during tumor development.", "negative": "Intra-cerebroventricular infusion of amyloid-\u03b2 oligomers increases expression of fibronectin type-III domain-containing protein 5 mRNA in mice hippocampi.", "negatives": ["Intra-cerebroventricular infusion of amyloid-\u03b2 oligomers increases expression of fibronectin type-III domain-containing protein 5 mRNA in mice hippocampi.", "PKG-la does not have a large impact on expression of pain hypersensitivity in PGK-la knockout mice.", "Aged patients are less susceptible to ischaemia/reperfusion injury.", "Converting apoE4 to apoE3 by gene editing prevents the pathology associated with apoE4 in human iPSCderived neurons.", "Chemical injury represses transglutaminase 2 activity.", "ER-localized phosphatase Sac1 processes PI4P through coordination with OSBP and the endosome-localized protein sorting nexin 2.", "Higher plasma levels of I-carnitine, when associated with trimethylamine N-oxide, are negatively correlated with cardiovascular events in humans.", "Ethanol stress increases the expression of PSP in bacteria.", "Systemic immunosuppressive (IS) therapy increases the chance of cancer mortality in patients with inflammatory eye disease (IED)", "In British Men, haplogroup I increases risk of cardiovascular disease by 50%."], "hard_negatives": ["Pro-inflammatory cytokines are up regulated during tumor development.", "Tumor development occurs in conjunction with upregulation of pro-inflammatory cytokines.", "Pro-inflammatory cytokines are up repressed during tumor development.", "Tumor development occurs in conjunction with suppression of pro-inflammatory cytokines.", "Many cytokines that are produced by cancer cells also contribute to carcinogenesis.", "Cancer-associated fibroblasts (CAFs) interact with cancer cells to mediate formation and activation of CAFs.", "Primary pro-inflammatory cytokines suppress secondary pro- and anti-inflammatory mediators.", "Cancer-associated fibroblasts (CAFs) have no known interaction with cancer cells in the formation and activation of CAFs.", "The cytokine receptor which regulates chemotaxis and formation of lymph nodes is involved in production of myeloperoxidase in the left atrium.", "Cancer-associated fibroblasts (CAFs) are constituents of tumor microenvironments"], "hard_negative": "Pro-inflammatory cytokines are up regulated during tumor development."}
{"query_id": "978", "query_text": "Pro-inflammatory cytokines are up repressed during tumor development.", "negative": "Vitamin D is an important factor in the relationship between calcium and parathyroid hormone.", "negatives": ["Vitamin D is an important factor in the relationship between calcium and parathyroid hormone.", "Low nucleosome occupancy correlates with high methylation levels across species.", "MafA ubiquitination decreases the recruitment of coavtivator P/CAF by MafA.", "miRNAs regulate a unique suite of mRNAs to maintain homeostasis in cells.", "The H2A-H2B eviction defect is compensated for by other histone chaperone(s).", "Dexamethasone increases risk of postoperative bleeding.", "Specialized functional cell types can be derived from human pluripotent stem cells.", "The repeat-variable diresidue (RVD) in the loop of Transcription-Activator Like (TAL) effectors specifies the nucleotides-amino acid contact at the target promoter element.", "Blocking the interaction between TDP-43 and respiratory complex I proteins ND3 and ND6 prevents TDP-43-induced neuronal loss.", "Destination container port throughput(CPT) is positively related to dengue virus (DENV-1) diffusion in air traffic shipments."], "hard_negatives": ["Pro-inflammatory cytokines are up regulated during tumor development.", "Pro-inflammatory cytokines are up repressed during tumor development.", "Tumor development occurs in conjunction with upregulation of pro-inflammatory cytokines.", "Tumor development occurs in conjunction with suppression of pro-inflammatory cytokines.", "Many cytokines that are produced by cancer cells also contribute to carcinogenesis.", "Primary pro-inflammatory cytokines suppress secondary pro- and anti-inflammatory mediators.", "Cancer-associated fibroblasts (CAFs) interact with cancer cells to mediate formation and activation of CAFs.", "Cancer-associated fibroblasts (CAFs) have no known interaction with cancer cells in the formation and activation of CAFs.", "Cancer cells can stimulate the accumulation of intra-tumoural myeloid-derived suppressor cells by promoting granulocyte colony stimulating factor production.", "Cancer-associated fibroblasts (CAFs) are constituents of tumor microenvironments"], "hard_negative": "Pro-inflammatory cytokines are up regulated during tumor development."}
{"query_id": "979", "query_text": "Progerin induces premature aging in stem cells.", "negative": "AMP-activated protein kinase (AMPK) activation reduces inflammation-related fibrosis in the lungs.", "negatives": ["AMP-activated protein kinase (AMPK) activation reduces inflammation-related fibrosis in the lungs.", "LSD1-positive promoters are associated with RNA polymerase II", "BLM gene encodes RecQ-class DNA helicase.", "In transgenic mice harboring green florescent protein under the control of the Sox2 promoter, more than 50 percent of the cells with green florescent colocalize with cell proliferation markers.", "Roughly 55% of women with chronic pelvic pain have no underlying pathology.", "Pyridostatin stabilizes the G - quadruplex in the telomeric region.", "Foxp3 enables the expression of transcriptional regulators implicated in memory T cell development.", "Guanine nucleotide exchange factors (GEFs) mediate RhoA activation in response to tensional forces on fibronectin-binding integrins.", "Differentiation of progenitor cells to myeloid cells is skewed upon activation of insulin signaling.", "YAP/TAZ is required in intestinal regeneration in mouse models of ulcerative colitis."], "hard_negatives": ["Progerin induces premature aging in stem cells.", "Environmentally-induced senescence is mimicked in disease modeling by adding specific molecules to the culture system.", "Up-regulation of the p53 pathway and related molecular events speeds cancer progression.", "eRNAs influence is linked to senescence, aging, and carcinogenesis.", "Autophagy deficiency in the liver increases vulnerability to insulin resistance.", "Cellular differentiation of embryonic stem cells is accompanied by changes in replication timing, transcription and nuclear localization.", "Rapamycin delays aging in fruit flies.", "Physical injury represses transgultaminase activity.", "Activated Cdk5 regulates DNA damage-induced neuronal death.", "The proliferative capacity of progenitors is regulated cell-autonomously."], "hard_negative": "Progerin induces premature aging in stem cells."}
{"query_id": "980", "query_text": "Propriospinal interneurons that play a role in the plastic reorganization of spinal circuits are integral for recovery from spinal cord injury.", "negative": "AMP-activated protein kinase (AMPK) activation reduces inflammation-related fibrosis in the lungs.", "negatives": ["AMP-activated protein kinase (AMPK) activation reduces inflammation-related fibrosis in the lungs.", "Dexamethasone increases risk of postoperative bleeding.", "Removal of H3K9me3 by ectopic expression of other H3K9 demethylases improves reprogramming efficiency in SCNT experiments.", "aPKCz causes tumour suppression by affecting glutamine metabolism.", "Activation of PPM1D enhances p53 function.", "taa1 tar1 tar2 triple mutants in Arabidopsis do not make root meristem during embryogenesis.", "Lack of FGF21 in mice leads to atherosclerotic plaque formation.", "Bacterial meningitis can be diagnosed on the basis of positive cerebrospinal fluid (CSF) cultures.", "76-85% of people with severe mental disorder receive no treatment in low and middle income countries.", "Natriuretic peptides increase susceptibility to diabetes."], "hard_negatives": ["Propriospinal interneurons that play a role in the plastic reorganization of spinal circuits are integral for recovery from spinal cord injury.", "Surgical treatment is not superior to non-surgical in treating adults with displaced fractures of the proximal humerus.", "Rotator cuff exercises are more effective than general exercise therapy in reducing pain and improving function of the shoulder.", "The proliferative capacity of neural progenitors differs across species.", "PKG-la plays an essential role in expression of spinal long term potentiation in PGK-la knockout mice.", "The myocardial cell lineage originally develops from cardiac progenitors of exclusively endodermal origin.", "Osteoparthritis (OA) is characterized by degeneration of articular cartilage, joint edge, and subchondral bone hyperplasia.", "PKG-la does not have a large impact on expression of spinal long term potentiation in PGK-la knockout mice.", "General exercise therapy is more effective than rotator cuff exercises in reducing pain and improving function of the shoulder.", "Sudden death can occur in patients with complex ventricular arrhythmias."], "hard_negative": "Propriospinal interneurons that play a role in the plastic reorganization of spinal circuits are integral for recovery from spinal cord injury."}
{"query_id": "984", "query_text": "Pseudogene PTENP1 encodes a transcript that regulates PTEN expression.", "negative": "There was an estimated 30 million cases of pneumonia in young children worldwide in 2010.", "negatives": ["There was an estimated 30 million cases of pneumonia in young children worldwide in 2010.", "M. stadtmanae induces ASC speck formation in BlaER1 monocytes.", "Taxation of sugar-sweetened beverages reduced the incidence rate of type II diabetes in India.", "Asymptomatic visual impairment screening in elderly populations leads to improved vision.", "Men are more susceptible to death due to pneumonia when compared to women.", "Monoclonal antibody targeting of N-cadherin encourages castration resistance.", "Insulin decreases risk of severe kidney failure.", "Hematopoietic Stem Cell purification reaches purity rates above 90%.", "Nonsteroidal antinflammatory drugs show potential anticancer indications.", "32% of liver transplantation programs required patients to discontinue methadone treatment in 2001."], "hard_negatives": ["Pseudogene PTENP1 encodes a transcript that regulates PTEN expression.", "PTEN is a regulator for the transcriptional activity of SRF", "Foxp3 enables the expression of transcriptional regulators implicated in memory T cell development.", "Foxp3 represses the expression of transcriptional regulators implicated in memory T cell development.", "TNFAIP3 is a glioblastoma tumor suppressor.", "TNFAIP3 is a glioblastoma tumor enhancer.", "MEK inhibitors are effective treatments in RAS-driven mouse models of cancer.", "TNFAIP3 is a tumor enhancer in glioblastoma.", "Forkhead 0 (fox0) transcription factors are involved in apoptosis.", "Up-regulation of the p53 pathway and related molecular events speeds cancer progression."], "hard_negative": "Pseudogene PTENP1 encodes a transcript that regulates PTEN expression."}
{"query_id": "988", "query_text": "Pseudoknots are not evolutionarily conserved in most eukaryotes.", "negative": "Roughly 55% of women with chronic pelvic pain have no underlying pathology.", "negatives": ["Roughly 55% of women with chronic pelvic pain have no underlying pathology.", "The first MBT repeat of the four malignant brain tumor (4MBT) domain of Drosophila's Sfmbt and of the orthologous mammalian L3MBTL2 is required for the interaction with the spacer region of Drosophila's Pleiohomeotic (Pho) or its human ortholog YY1.", "Over half of the gabonese children with Schimmelpenning-Feuerstein-Mims syndrome (SFM) had a plasma lactate of more than 5mmol/L.", "Pioneer factor OCT3/4 interacts with major chromatin remodeling factors.", "The PRDM1 gene, when combined with the PRDM14 gene, plays an important role during primordial germ cell specification.", "Induction of urokinase receptor signaling in podocytes causes foot process effacement and proteinuria.", "Destination container port throughput(CPT) is positively related to dengue virus (DENV-1) diffusion in air traffic shipments.", "Major vault protein (MVP) leads to more aggressive tumors by regulating the sorting of tumor suppressive miR-193a into extracellular vesicles (EVs).", "Tirasemtiv has no effect on cardiac muscle.", "Myelin sheaths are lipid-rich cellular structures."], "hard_negatives": ["Pseudoknots are not evolutionarily conserved in most eukaryotes.", "Pre-mRNAs associated with spliceosomal components are less stable than unassociated splicing substrates.", "Pre-mRNAs associated with spliceosomal components are more stable than unassociated splicing substrates.", "Genes involved in pre-mRNA splicing have a significant impact on genome stability.", "mcm 5 s 2 U is required for proper decoding of NNR codons in eukaryotes.", "Ribosomopathies have a high degree of cell and tissue specific pathology.", "miRNAs enforce homeostasis by suppressing low-level ''leaky'' transcription.", "Sequence conservation in gene regulatory regions between species is a poor predictor of conserved functionality.", "Sequence conservation in gene regulatory regions between species is a high-accuracy predictor of conserved functionality.", "Low nucleosome occupancy correlates with high methylation levels across species."], "hard_negative": "Pseudoknots are not evolutionarily conserved in most eukaryotes."}
{"query_id": "989", "query_text": "Pure neural progenitor cell (NPC) populations can only be obtained from cell cultures that undergo passaging, filtration, or other isolation and cell sorting methods.", "negative": "Medications to treat obesity do not have side effects.", "negatives": ["Medications to treat obesity do not have side effects.", "There is a positive correlation between hip fractures and statin use.", "AZT given with ribavirin increases anemia.", "Measuring routine outcomes is more beneficial to clinical practice than assessing treatment adherence.", "MICAL redox enzymes regulate actin dynamics.", "Monoclonal antibody targeting of N-cadherin inhibits growth.", "The morphology change from large white adipocytes to small brown adipocytes is a sign of increased energy expenditure potential in white adipose tissue.", "COPI coatmer is involved in lipid homeostasis.", "HbA1c consistently overestimates glycemic control in black individuals with Sickle cell trait (SCT).", "TNFAIP3 is a glioblastoma tumor enhancer."], "hard_negatives": ["Pure neural progenitor cell (NPC) populations can only be obtained from cell cultures that undergo passaging, filtration, or other isolation and cell sorting methods.", "The proliferative capacity of neural progenitors differs across species.", "The proliferative capacity of progenitors is regulated cell-autonomously.", "0-dimensional biomaterials lack inductive properties.", "Human embryonic stem cells have the capacity to give rise to differentiated progeny representative of all three embryonic germ layers.", "Human embryonic stem cells give rise to cell types from the outer embryonic germ layer, but not the other two layers.", "Upregulation of dynein in Drosophila neurons increases the number of microtubule plus-ends growing toward the cell body of each neuron.", "Environmentally-induced senescence is mimicked in disease modeling by adding specific molecules to the culture system.", "HIV trans-activator protein (TAT) effectively transports large and small molecules across cellular membranes into larger populations of neurons.", "Nuclear transfer from adult human fibroblasts to human oocytes can give rise to blastocysts containing expandable pluripotent cells."], "hard_negative": "Pure neural progenitor cell (NPC) populations can only be obtained from cell cultures that undergo passaging, filtration, or other isolation and cell sorting methods."}
{"query_id": "990", "query_text": "Pyridostatin decreases telomere fragility in BRCA2-deficient cells.", "negative": "Systemic lupus erythematosus is a risk factor for cardiovascular disease.", "negatives": ["Systemic lupus erythematosus is a risk factor for cardiovascular disease.", "Medications to treat obesity do not have side effects.", "Cholesterol loading induces KLF4 expression in VSMCs, resulting in the expression of pro-inflammatory cytokines.", "Increased flux of microbial products provokes immune responses.", "Certain immunomodulator-human dialyzable leukocyte extract (hDLE) peptides are recognized by toll-like receptors (TLRs) on macrophages and dendritic cells.", "N348I mutations reduce resistance to nevirapine.", "Increased microtubule acetylation repairs interference of axonal transport caused by LRRK2 Roc-COR domain mutations.", "PRC1-bound plasmids sediment at a slower rate in unbound plasmids than in sucrose gradients.", "The innate immune response struggles to remove small numbers of parasites.", "ART has no effect on the infectiveness of HIV-positive people."], "hard_negatives": ["Pyridostatin decreases telomere fragility in BRCA2-deficient cells.", "Pyridostatin stabilizes the G - quadruplex in the telomeric region.", "Pyridostatin induces double-strand breaks accumulation.", "Pyridostatin prevents double-strand breaks accumulation.", "Pyridostatin reduces proliferation of homologous recombination - defective cells.", "Pyridostatin deregulates G2/M progression.", "Pyridostatin encourages proliferation of homologous recombination - defective cells.", "Pyridostatin induces checkpoint activation.", "Reduced phosphorylation of PP2A increases HDAC4 dephosphorylation by enhancing PP2A-HDAC4 interaction.", "The C-type lectin receptor (CLEC-2) rearranges the actin cytoskeleton in dendritic cells to promote efficient motility along stromal surfaces."], "hard_negative": "Pyridostatin decreases telomere fragility in BRCA2-deficient cells."}
{"query_id": "992", "query_text": "Pyridostatin deregulates G2/M progression.", "negative": "Lamins are associated with nuclear membrane structure maintenance.", "negatives": ["Lamins are associated with nuclear membrane structure maintenance.", "The tip of the inner tube of the toxic type VI secretion system (T6SS) antibacterial effector in Escherichia coli (E. coli) is decorated with VgrG and PAAR proteins.", "Pediatric SCD patients with vaso-occlusive crisis show increased morphine use after breathing 80 ppm iNO for 4 hours.", "Ten percent (10%) of kidney cancers in the UK are attributable to excess weight.", "F4/80+ macrophages regulate mature osteoblast maintenance.", "Concentrations of SNV and CNV in stem-cell regulatory elements and binding sites of transcription factors in iPSC-lines are distinct from their founding cells.", "Students who perform poorly in the early years of medical school are less likely to commit professional misconduct later in their careers.", "4-PBA treatment decreases endoplasmic reticulum stress in response to general endoplasmic reticulum stress markers.", "Ribosomal protein (RP) expression is controlled in part by stress-activated regulators.", "Inhibiting focal adhesion formation enables cells to convert mechanical strain into eventual scarring."], "hard_negatives": ["Pyridostatin deregulates G2/M progression.", "Pyridostatin stabilizes the G - quadruplex in the telomeric region.", "Pyridostatin induces double-strand breaks accumulation.", "Pyridostatin reduces proliferation of homologous recombination - defective cells.", "Pyridostatin induces checkpoint activation.", "Pyridostatin prevents double-strand breaks accumulation.", "Pyridostatin encourages proliferation of homologous recombination - defective cells.", "Pyridostatin decreases telomere fragility in BRCA2-deficient cells.", "Mutations in G-Beta protein GNB1 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.", "The deamination of cytidine to uridine on the minus strand of viral DNA can inactivate the viral genome by inducing G-to-A mutations."], "hard_negative": "Pyridostatin deregulates G2/M progression."}
{"query_id": "994", "query_text": "Pyridostatin encourages proliferation of homologous recombination - defective cells.", "negative": "Environmentally-induced senescence is mimicked in disease modeling by adding specific molecules to the culture system.", "negatives": ["Environmentally-induced senescence is mimicked in disease modeling by adding specific molecules to the culture system.", "PrimPol generates short DNA replication intermediates on the leading strand during DNA replication.", "Eliminating the last sporadic cases of malaria requires considerable funding.", "In patients with congenital heart defects, \u03b2-blockers significantly improve clinical heart failure outcomes.", "The peak incidence of fractures occurs in toddlers.", "Tumor development occurs in conjunction with upregulation of pro-inflammatory cytokines.", "Foxp3 enables the expression of transcriptional regulators implicated in memory T cell development.", "Ultrasound guidance significantly reduces the number of needle insertion attempts necessary for a given procedure.", "Sepsis related mortality has risen from 2009 to 2014.", "Genomic aberrations of metastases provide information for targeted therapy."], "hard_negatives": ["Pyridostatin encourages proliferation of homologous recombination - defective cells.", "Pyridostatin reduces proliferation of homologous recombination - defective cells.", "Pyridostatin induces double-strand breaks accumulation.", "Pyridostatin prevents double-strand breaks accumulation.", "Pyridostatin induces checkpoint activation.", "Pyridostatin deregulates G2/M progression.", "Pyridostatin stabilizes the G - quadruplex in the telomeric region.", "Pyridostatin decreases telomere fragility in BRCA2-deficient cells.", "The deamination of cytidine to uridine on the minus strand of viral DNA can inactivate the viral genome by inducing G-to-A mutations.", "Cyclin A2 destruction is necessary to switch from unstable to stable kt-mt attachments in mitosis."], "hard_negative": "Pyridostatin encourages proliferation of homologous recombination - defective cells."}
{"query_id": "996", "query_text": "Pyridostatin induces checkpoint activation.", "negative": "mcm 5 s 2 U is required for proper decoding of NNR codons in eukaryotes.", "negatives": ["mcm 5 s 2 U is required for proper decoding of NNR codons in eukaryotes.", "Cost effectiveness evaluations based on cRCT data lack external validity.", "Adult tissue-resident macrophages stem from the embryonal yolk sac and fetal liver.", "1-1% of colorectal cancer patients are diagnosed with regional or distant metastases.", "Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes fibrosis.", "The ability of activator E2Fs in preventing cell death is limited to terminally differentiated cells.", "The minor G allele of FOXO3 up-regulates IL-10.", "Pseudogene PTENP1 encodes a transcript that regulates PTEN expression.", "DUSP4 decreases apoptosis.", "taa1 tar1 tar2 triple mutants in Arabidopsis do not make root meristem during embryogenesis."], "hard_negatives": ["Pyridostatin induces checkpoint activation.", "Pyridostatin induces double-strand breaks accumulation.", "Pyridostatin prevents double-strand breaks accumulation.", "Pyridostatin reduces proliferation of homologous recombination - defective cells.", "Pyridostatin encourages proliferation of homologous recombination - defective cells.", "Pyridostatin deregulates G2/M progression.", "Pyridostatin stabilizes the G - quadruplex in the telomeric region.", "Pyridostatin decreases telomere fragility in BRCA2-deficient cells.", "The deamination of cytidine to uridine on the minus strand of viral DNA can inactivate the viral genome by inducing G-to-A mutations.", "Chemical injury represses transglutaminase 2 activity."], "hard_negative": "Pyridostatin induces checkpoint activation."}
{"query_id": "997", "query_text": "Pyridostatin induces double-strand breaks accumulation.", "negative": "Cost effectiveness evaluations based on cRCT data lack external validity.", "negatives": ["Cost effectiveness evaluations based on cRCT data lack external validity.", "miR-142-5P is a known regulator of raised body temperature.", "MafA phosphorylation decreases its ubiquitination.", "Ca2+ cycling is a UCP1-dependent thermogenic mechanism.", "Increased flux of microbial products provokes immune responses.", "LRBA prevents CTLA - 4 recycling.", "Major antigen-induced signals from the T cell receptor and secondary signals from costimulatory receptors are required for T cell activation.", "Mice defective for deoxyribonucleic acid (DNA) polymerase m (polm) fail to reveal increased sensitivity to ionizing radiation (IR).", "Adult tissue-resident macrophages are seeded before birth.", "Pediatric SCD patients with vaso-occlusive crisis show increased morphine use after breathing 80 ppm iNO for 4 hours."], "hard_negatives": ["Pyridostatin induces double-strand breaks accumulation.", "Pyridostatin prevents double-strand breaks accumulation.", "Pyridostatin induces checkpoint activation.", "Pyridostatin reduces proliferation of homologous recombination - defective cells.", "Pyridostatin encourages proliferation of homologous recombination - defective cells.", "Pyridostatin stabilizes the G - quadruplex in the telomeric region.", "Pyridostatin deregulates G2/M progression.", "Pyridostatin decreases telomere fragility in BRCA2-deficient cells.", "The deamination of cytidine to uridine on the minus strand of viral DNA can inactivate the viral genome by inducing G-to-A mutations.", "RAD52 is involved in break-induced DNA replication (BIR)."], "hard_negative": "Pyridostatin induces double-strand breaks accumulation."}
{"query_id": "998", "query_text": "Pyridostatin prevents double-strand breaks accumulation.", "negative": "Urbanization is an important risk factor related to the transmission of dengue fever.", "negatives": ["Urbanization is an important risk factor related to the transmission of dengue fever.", "CDK6 shows impaired binding to loss-of-function variants of p18 INK4C.", "TRAP+ osteoclasts regulate mature osteoblast maintenance.", "Patients with common epithelial cancers  are more likely to have an emergency event as their first hospital admission if they live in resource-deprived areas.", "Active Ly49Q prevents neutrophil polarization.", "Physical injury represses transgultaminase activity.", "Low expression of miR7a does not repress target genes or exert a biological function in testis.", "Lipopolysaccharides have an inflammation independent effect on kidney barrier function.", "Glioblastoma multiforme (GBM) is characterized by extensive invasion, rapid growth, necrosis, and angiogenesis.", "Intra-cerebroventricular infusion of amyloid-\u03b2 oligomers increases expression of fibronectin type-III domain-containing protein 5 mRNA in mice hippocampi."], "hard_negatives": ["Pyridostatin prevents double-strand breaks accumulation.", "Pyridostatin induces double-strand breaks accumulation.", "Pyridostatin reduces proliferation of homologous recombination - defective cells.", "Pyridostatin induces checkpoint activation.", "Pyridostatin encourages proliferation of homologous recombination - defective cells.", "Pyridostatin stabilizes the G - quadruplex in the telomeric region.", "Pyridostatin deregulates G2/M progression.", "Pyridostatin decreases telomere fragility in BRCA2-deficient cells.", "The deamination of cytidine to uridine on the minus strand of viral DNA can inactivate the viral genome by inducing G-to-A mutations.", "RAD52 is involved in break-induced DNA replication (BIR)."], "hard_negative": "Pyridostatin prevents double-strand breaks accumulation."}
{"query_id": "999", "query_text": "Pyridostatin reduces proliferation of homologous recombination - defective cells.", "negative": "Environmentally-induced senescence is mimicked in disease modeling by adding specific molecules to the culture system.", "negatives": ["Environmentally-induced senescence is mimicked in disease modeling by adding specific molecules to the culture system.", "The Snf1 complex regulates carbon and energy metabolism in baker's yeast (Saccharomyces cerevisiae).", "Insulin decreases risk of severe kidney failure.", "Risedronate increases risk of vertebral and non-vertebral fractures.", "Patients with common epithelial cancers are less likely to have an emergency event as their first hospital admission if they live in resource-deprived areas.", "Sepsis related mortality has remained stable between 2009-2014.", "Replacement of OCT4 and SOX2 genes with GATA3 is not capable of reprogramming human cells.", "The PPR MDA5 has twenty N-terminal CARD domains.", "Long chain polyunsaturated fatty acids supplementation is associated with lower rates of atopic eczema at 1 year.", "Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection decreases dissemination of Salmonella Typhimurium from the gut."], "hard_negatives": ["Pyridostatin reduces proliferation of homologous recombination - defective cells.", "Pyridostatin encourages proliferation of homologous recombination - defective cells.", "Pyridostatin induces double-strand breaks accumulation.", "Pyridostatin prevents double-strand breaks accumulation.", "Pyridostatin induces checkpoint activation.", "Pyridostatin deregulates G2/M progression.", "Pyridostatin stabilizes the G - quadruplex in the telomeric region.", "Pyridostatin decreases telomere fragility in BRCA2-deficient cells.", "The deamination of cytidine to uridine on the minus strand of viral DNA can inactivate the viral genome by inducing G-to-A mutations.", "Chemical injury represses transglutaminase 2 activity."], "hard_negative": "Pyridostatin reduces proliferation of homologous recombination - defective cells."}
{"query_id": "1000", "query_text": "Pyridostatin stabilizes the G - quadruplex in the telomeric region.", "negative": "Prescribed exercise training improves quality of life.", "negatives": ["Prescribed exercise training improves quality of life.", "Taxation of sugar-sweetened beverages reduced the incidence rate of type II diabetes in India.", "Normal granulomas form in the presence of TNF in Zebrafish.", "AZT given with ribavirin increases anemia.", "50% of patients exposed to radiation have activated markers of mesenchymal stem cells.", "The generation of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells.", "ERAP1 SNPs are epistatic to HLA alleles for ankylosing spondylitis.", "Satellite cell dysfunction is a key factor in sarcopenia development.", "Lipopolysaccharides have an inflammation independent effect on kidney barrier function.", "In the UK, drowning affects boys and girls equally."], "hard_negatives": ["Pyridostatin stabilizes the G - quadruplex in the telomeric region.", "Pyridostatin induces double-strand breaks accumulation.", "Pyridostatin deregulates G2/M progression.", "Pyridostatin prevents double-strand breaks accumulation.", "Pyridostatin decreases telomere fragility in BRCA2-deficient cells.", "Pyridostatin reduces proliferation of homologous recombination - defective cells.", "Pyridostatin encourages proliferation of homologous recombination - defective cells.", "Pyridostatin induces checkpoint activation.", "Formation of N-terminal pyroglutamate by glutamine cyclase (GC) competes with NTAQ1 for Nt-Gln substrates.", "Oxidative phosphorylation is one of the primary glycometabolic pathways in cells."], "hard_negative": "Pyridostatin stabilizes the G - quadruplex in the telomeric region."}
{"query_id": "1001", "query_text": "R2D2 stops miRNA production by increasing the selectivity of Dcr2 for long dsRNA.", "negative": "The NF-\u03baB essential modulator gene prevents intestinal inflammation by inhibiting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death.", "negatives": ["The NF-\u03baB essential modulator gene prevents intestinal inflammation by inhibiting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death.", "Women are more susceptible to death due to pneumonia when compared to men.", "Pyridostatin decreases telomere fragility in BRCA2-deficient cells.", "Upon viral challenge, influenza-specific memory CD4+ T cells greatly enhance the early production of inflammatory chemokines in the lung.", "Toll-like receptor (TLR) signaling is involved in the pathogenesis of human MDS.", "Varying expression levels of EBI2 affect the positioning and migration of B cells.", "Normal granulomas form in the presence of TNF in Zebrafish.", "The recruitment of Wdr5 to its target loci depends on Kat8.", "The myocardial cell lineage originally develops from cardiac progenitors of exclusively endodermal origin.", "Systemic immunosuppressive (IS) therapy increases the chance of cancer mortality in patients with inflammatory eye disease (IED)"], "hard_negatives": ["R2D2 stops miRNA production by increasing the selectivity of Dcr2 for long dsRNA.", "The PPR MDA5 has twenty N-terminal CARD domains.", "The PRR MDA5 has a C-terminal domain.", "mcm 5 s 2 U is required for proper decoding of NNR codons in eukaryotes.", "N348I mutations cause resistance to nevirapine.", "Low expression of miR7a does not repress target genes or exert a biological function in testis.", "Low expression of miR7a does not repress target genes or exert a biological function in ovaries.", "N348I mutations reduce resistance to nevirapine.", "miR-142-5P is a temperature-sensitive microRNA (miRNA).", "Gpr124 suppresses BBB breakdown in mouse models of ischemic stroke."], "hard_negative": "R2D2 stops miRNA production by increasing the selectivity of Dcr2 for long dsRNA."}
{"query_id": "1002", "query_text": "RA activation of DIF2 and NB4 cells induces hallmarks of transcriptionally active promoters.", "negative": "0-dimensional biomaterials lack inductive properties.", "negatives": ["0-dimensional biomaterials lack inductive properties.", "The most prevalent adverse events to Semaglutide are cardiovascular.", "Mitochondria play a major role in apoptosis.", "Increased microtubule acetylation exacerbates LRRK2 Roc-COR domain mutation induced locomotor deficits.", "Gpr124 increases BBB breakdown in mouse models of ischemic stroke.", "Microglia are an innate immune cell type of the peripheral nervous system.", "Pyridostatin encourages proliferation of homologous recombination - defective cells.", "Patients in stable partnerships progress from HIV to death at the same rate as patients not in partnerships.", "Up-regulation of the p53 pathway and related molecular events speeds cancer progression.", "Rhythmic expression of Cry1 translates directly into a circadian regulation of cAMP signaling in hepatic glucose metabolism."], "hard_negatives": ["RA activation of DIF2 and NB4 cells induces hallmarks of transcriptionally active promoters.", "LSD1-positive promoters are associated with RNA polymerase II", "Replacement of histone H2A with H2A.Z accelerates gene activation in yeasts by destabilizing +1 nucleosomes.", "Binding of p53 to enhancer regions (p53BERs) regulates the activity of p53 transcription and cell cycle arrest through the production of p53-dependent eRNAs.", "B3-Galectin decreases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR.", "B3-Galectin increases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR.", "Activated Cdk5 regulates DNA damage-induced neuronal death.", "Long - range chromatin interactions regulate transcription.", "The repeat-variable diresidue (RVD) in the loop of Transcription-Activator Like (TAL) effectors specifies the nucleotides-amino acid contact at the target promoter element.", "Mutations in G-Beta protein GNB1 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway."], "hard_negative": "RA activation of DIF2 and NB4 cells induces hallmarks of transcriptionally active promoters."}
{"query_id": "1003", "query_text": "RAD52 is involved in break-induced DNA replication (BIR).", "negative": "Pioglitazone use is not associated with an increased risk of prostate cancer.", "negatives": ["Pioglitazone use is not associated with an increased risk of prostate cancer.", "V-9302 inhibits antitumor responses by decreasing cell death and oxidative stress.", "Deletion of ATM and Rad3 related protein is not predictive of acute tissue loss.", "Taking 400mg of \u03b1-tocopheryl acetate does not prevent prostate cancer.", "Pharmacist attendance at ward rounds reduces adverse events in wards.", "Individuals with low serum vitamin D concentrations have decreased risk of multiple sclerosis.", "Comparative transcriptome analysis identified new platelet proteins with structural features suggesting a role in platelet function.", "V-9302 inhibits antitumor responses by decreasing cell death and oxidative stress.", "Post-transcriptional handling of mitochondrial transcripts occurs in mitochondrial RNA granules.", "MafA phosphorylation enhances its ubiquitination."], "hard_negatives": ["RAD52 is involved in break-induced DNA replication (BIR).", "ATM and Rad3 related protein are critical for sensing DNA damage.", "ATM and Rad3 related protein have no role in sensing DNA damage.", "Gpr124 suppresses BBB breakdown in mouse models of ischemic stroke.", "The PPR MDA5 has twenty N-terminal CARD domains.", "Genes involved in pre-mRNA splicing have a significant impact on genome stability.", "Mutations in RIM1 decrease levels of IME1 RNA.", "Mutations in RIM1 raise levels of IME1 RNA.", "BLM gene encodes RecQ-class DNA helicase.", "Toll-like receptor (TLR) signaling is involved in the pathogenesis of human MDS."], "hard_negative": "RAD52 is involved in break-induced DNA replication (BIR)."}
{"query_id": "1004", "query_text": "RANK-RANKL pathway signalling has no known association with development of Aire-expressing medullary thymic epithelial cells.", "negative": "Treatment with a protein named FN impairs regenerative abilities of aged muscles.", "negatives": ["Treatment with a protein named FN impairs regenerative abilities of aged muscles.", "Reduced phosphorylation of PP2A increases HDAC4 dephosphorylation by enhancing PP2A-HDAC4 interaction.", "siRNA knockdown of A20 slows tumor progression in an in vivo murine xenograft model.", "Cancer cells can stimulate the accumulation of intra-tumoural myeloid-derived suppressor cells by promoting granulocyte colony stimulating factor production.", "Tuberculosis-induced granulomas express different immune system protein signatures than the surrounding tissue.", "Pioneer factor OCT3/4 interacts with major chromatin remodeling factors.", "Patients with panic anxiety show decreased CSF levels of hypocretin.", "Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 inhibit West Nile virus replication in cortical neurons.", "FACT and other histone chaperone(s) compensate for Histone 2A (H2A)-histone 2B (H2B) dimer eviction during the histone exchange process.", "ScPif1p has reduced binding ability to G-rich ssDNA compared to non-G-rich ssDNA."], "hard_negatives": ["The RANK-RANK-Ligand (RANKL) pathway is involved in the development of Aire-expressing medullary thymic epithelial cells (mTECs).", "RANK-RANKL pathway signalling has no known association with development of Aire-expressing medullary thymic epithelial cells.", "RANK-RANKL pathway signalling is linked to development of Aire-expressing medullary thymic epithelial cells.", "KRT17 modulates the expression of the transcriptional regulator AIRE in diseased epithelia.", "AMP-activated protein kinase (AMPK) activation reduces inflammation-related fibrosis in the lungs.", "The NF-\u03baB essential modulator gene induces intestinal inflammation by promoting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death.", "The NF-\u03baB essential modulator gene prevents intestinal inflammation by inhibiting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death.", "ITAM phosphorylation allows for the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).", "Inhibiting glucose-6-phospate dehydrogenase improves lipogenesis by deactivating LKB1-AMPK signaling.", "Ly6C hi monocytes have a higher inflammatory capacity than Ly6C lo monocytes."], "hard_negative": "The RANK-RANK-Ligand (RANKL) pathway is involved in the development of Aire-expressing medullary thymic epithelial cells (mTECs)."}
{"query_id": "1005", "query_text": "RANK-RANKL pathway signalling is linked to development of Aire-expressing medullary thymic epithelial cells.", "negative": "Immune complex triggered cell death leads to sequestration of oxidized mitochondrial DNA.", "negatives": ["Immune complex triggered cell death leads to sequestration of oxidized mitochondrial DNA.", "A breast cancer patient's capacity to metabolize tamoxifen influences treatment outcome.", "Lamins have no effect on nuclear membrane structure maintenance.", "Patients in stable partnerships progress from HIV to death at the same rate as patients not in partnerships.", "The appearance of brown-like or beige cells primarily occurs in visceral fat, not subcutaneous fat.", "Long chain polyunsaturated fatty acids supplementation reduces wheezing and asthma.", "Ectopic expression of Sall4, Nanog, Esrrb, and Lin28 generates induced pluripotent stem cells from mouse embryonic fibroblasts more efficiently than other factor combinations.", "Distant CREs are important for transcriptional regulation.", "The deregulated and prolonged activation of monocytes has deleterious effects in chronic infectious conditions.", "The DEXI promoter region is bound by multiple transcription factors in a murine haematopoietic progenitor cell line."], "hard_negatives": ["The RANK-RANK-Ligand (RANKL) pathway is involved in the development of Aire-expressing medullary thymic epithelial cells (mTECs).", "RANK-RANKL pathway signalling is linked to development of Aire-expressing medullary thymic epithelial cells.", "RANK-RANKL pathway signalling has no known association with development of Aire-expressing medullary thymic epithelial cells.", "KRT17 modulates the expression of the transcriptional regulator AIRE in diseased epithelia.", "AMP-activated protein kinase (AMPK) activation reduces inflammation-related fibrosis in the lungs.", "The NF-\u03baB essential modulator gene induces intestinal inflammation by promoting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death.", "The NF-\u03baB essential modulator gene prevents intestinal inflammation by inhibiting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death.", "Occipital activation levels are associated with auditory spatial performance in parietal regions of the brain.", "Inhibiting glucose-6-phospate dehydrogenase improves lipogenesis by deactivating LKB1-AMPK signaling.", "Rhythmic expression of Cry1 translates directly into a circadian regulation of cAMP signaling in gluconeogenesis."], "hard_negative": "The RANK-RANK-Ligand (RANKL) pathway is involved in the development of Aire-expressing medullary thymic epithelial cells (mTECs)."}
{"query_id": "1006", "query_text": "RTEL1 interacts with TRF2 through a C4C4 motif", "negative": "Mutations in RIM1 raise levels of IME1 RNA.", "negatives": ["Mutations in RIM1 raise levels of IME1 RNA.", "90% of patients with melanoma and an objective response to PD-1 blockade will experience a progression in their melanoma.", "Lysine histone demethylase inhibitor JIB 04 is inactive against KDM5A.", "The artifactual C-terminal helix swapping in the StART domain is observed in the Ups1-Mdm35 heterodimer of the StARkin superfamily.", "BCL-2 promotes the apoptotic effects of c-Myc.", "Malaria has a high vectorial capacity.", "50% of patients exposed to radiation have activated markers of mesenchymal stem cells.", "Mice defective for deoxyribonucleic acid (DNA) polymerase m (polm) fail to reveal increased sensitivity to ionizing radiation (IR).", "Ca2+ cycling is a UCP1-independent thermogenic mechanism.", "Cancer-associated fibroblasts (CAFs) are constituents of tumor microenvironments"], "hard_negatives": ["RTEL1 interacts with TRF2 through a C4C4 motif", "Deltex interacts with eIF3. There is no known interaction between Deltex and elF3", "The PDPN gene deactivates the C-type lectin receptor (CLEC-2).", "The C-type lectin receptor (CLEC-2) rearranges the actin cytoskeleton in dendritic cells to promote efficient motility along stromal surfaces.", "The TRaF1/C5 rs10818488 allele polymorphism regulates the neighboring C5 gene.", "ATF4 is a general endoplasmic reticulum stress marker.", "Activated Cdk5 phosphorylates the ATM protein in response to DNA damage.", "Deltex has no known interactions with eIF3f.", "DUSP4 downregulation deactivates the Ras-ERK pathway", "MUC1-C activates the NF-\u03baB p65 signaling pathway by interacting with I\u03baB kinase \u00df."], "hard_negative": "RTEL1 interacts with TRF2 through a C4C4 motif"}
{"query_id": "1008", "query_text": "RUNX is not expressed in skin tissue.", "negative": "The PDPN gene deactivates the C-type lectin receptor (CLEC-2).", "negatives": ["The PDPN gene deactivates the C-type lectin receptor (CLEC-2).", "PrimPol degrades short DNA replication intermediates on the leading strand during DNA replication.", "Tonic signaling from the scFv prevents constitutive stimulation.", "Combination nicotine replacement therapies with varenicline or bupropion are more effective after 12 weeks of reatment compared to varenicline monotherapy.", "Differentiation of progenitor cells to myeloid cells is skewed upon activation of insulin signaling.", "Physical activity level is associated with the difference in maximal oxygen consumption between black and white youth.", "Nigerian physicians constitue the largest component of sub-Saharan Africa-trained physicians in the United States.", "Lamins are associated with nuclear membrane structure maintenance.", "Decrease of p62 in prostate tumor stroma results in defective autophagy.", "Many transmembrane receptors transmit signals by long-range conformational changes in the association of alpha-helices across the plasma membrane."], "hard_negatives": ["RUNX is not expressed in skin tissue.", "Normal expression of RUNX1 causes tumorsupressing effects.", "RUNX1 is downregulated or mutated in TLX1 T-ALL.", "PD-1 triggering on monocytes enhances IL-10 production by monocytes.", "Less than 10% of patients exposed to radiation have activated markers of mesenchymal stem cells.", "ALDH1 expression is associated with poorer prognosis for breast cancer primary tumors.", "Perigenital skin is not the primary site of HIV acquisition.", "IL-10 production by monocytes inhibits CD4 + T cell response.", "KRT17 modulates the expression of the transcriptional regulator AIRE in diseased epithelia.", "50% of patients exposed to radiation have activated markers of mesenchymal stem cells."], "hard_negative": "RUNX is not expressed in skin tissue."}
{"query_id": "1009", "query_text": "RUNX1 is downregulated or mutated in TLX1 T-ALL.", "negative": "Varying expression levels of EBI2 affect the positioning and migration of B cells.", "negatives": ["Varying expression levels of EBI2 affect the positioning and migration of B cells.", "Transplanted human glial progenitor cells can mature in their host animal.", "Patients with microcytosis and higher erythrocyte count are more vulnerable to severe malarial anaemia when infected with Plasmodium falciparum.", "M. stadtmanae does not induce ASC speck formation in BlaER1 monocytes.", "Chinese individuals with TT homozygosity in the MTHFR gene are less vulnerable to strokes caused by low levels of folate intake.", "Tirasemtiv targets fast-twitch muscle.", "Ectopic expression of Sall4, Nanog, Esrrb, and Lin28 generates induced pluripotent stem cells from mouse embryonic fibroblasts more efficiently than other factor combinations.", "One in two surgical randomized controlled trials are discontinued early.", "Expression of MSX2 is induced 3 hours after the addition of BMP4, which is earlier than T and CDX2.", "Oat tolerant coeliac patients may have oat specific inflammatory cells in their small bowel mucosa."], "hard_negatives": ["RUNX1 is downregulated or mutated in TLX1 T-ALL.", "Normal expression of RUNX1 causes tumorsupressing effects.", "Type 1 Diabetes is associated with subtle perturbations in T reg development.", "RUNX is not expressed in skin tissue.", "Reduced responsiveness to interleukin-2 in regulatory T cells is associated with autoimmune diseases such as Type 1 Diabetes.", "Expression of MSX2 is induced 3 hours after the addition of BMP4, which is earlier than T and CDX2.", "Major antigen-induced signals from the T cell receptor and secondary signals from costimulatory receptors are required for T cell activation.", "Foxp3 represses the expression of transcriptional regulators implicated in memory T cell development.", "In pediatric tissue, most T cells are naive T cell emigrants from the thymus.", "Foxp3 enables the expression of transcriptional regulators implicated in memory T cell development."], "hard_negative": "RUNX1 is downregulated or mutated in TLX1 T-ALL."}
{"query_id": "1011", "query_text": "Radioiodine treatment of non-toxic multinodular goitre increases thyroid volume.", "negative": "Activated Cdk5 phosphorylates the ATM protein in response to DNA damage.", "negatives": ["Activated Cdk5 phosphorylates the ATM protein in response to DNA damage.", "KRT17 modulates the expression of the transcriptional regulator AIRE in diseased epithelia.", "Stacking is more stable when a purine is present in the +5 position (C1698).", "Pro-inflammatory cytokines are up repressed during tumor development.", "Reduced responsiveness to interleukin-2 in regulatory T cells is associated with autoimmune diseases such as Type 1 Diabetes.", "HOXB4 facilitates HSC expansion when co-cultured with HSCs.", "Stiff substrates inhibit mesodermal differentiation by degrading beta-catenin in an integrin-dependent manner.", "Normal expression of RUNX1 causes tumorsupressing effects.", "PrimPol generates short DNA replication intermediates on the leading strand during DNA replication.", "Phase information is useful for predicting donor-recipient matches in organ transplantation."], "hard_negatives": ["Radioiodine treatment of non-toxic multinodular goitre increases thyroid volume.", "Metastatic colorectal cancer treated with a single agent fluoropyrimidines resulted in similar efficacy and better quality of life when compared with oxaliplatin-based chemotherapy in elderly patients.", "Thiopurine active metabolites can be catabolized through dephosphorylation of thioguanine nucleotides.", "A deficiency of folate increases blood levels of homocysteine.", "Increased vessel density along with a reduction in fibrosis improves the efficacy of chemotherapy treatments.", "In breast cancer, the loss of myoepithelial cells slows the transition of ductal carcinoma in situ to invasive carcinoma.", "40mg/day dosage of folic acid and 2mg/day dosage of vitamin B12 does not affect chronic kidney disease (CKD) progression.", "In breast cancer, the loss of myoepithelial cells promotes the transition of ductal carcinoma in situ to invasive carcinoma.", "Dexamethasone increases risk of postoperative bleeding.", "Risk of cardiovascular events can be cut by a third by using antihypertensive drug therapy among hemodialysis patients."], "hard_negative": "Radioiodine treatment of non-toxic multinodular goitre increases thyroid volume."}
{"query_id": "1015", "query_text": "Rapamycin delays aging in fruit flies.", "negative": "aPKCz causes tumour suppression by affecting glutamine metabolism.", "negatives": ["aPKCz causes tumour suppression by affecting glutamine metabolism.", "Early patent ductus ateriosus (PDA) screening increases in-hospital mortality.", "Incidence of heart failure increased by 10% in women since 1979.", "Ca2+ cycling controls whole-body energy homeostasis in beige fat.", "90% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.", "Over half of the gabonese children with Schimmelpenning-Feuerstein-Mims syndrome (SFM) had a plasma lactate of more than 5mmol/L.", "Having a main partner worsens HIV outcomes.", "Oxidative phosphorylation is one of the primary glycometabolic pathways in cells.", "Deltex interacts with eIF3. There is no known interaction between Deltex and elF3", "Mice that lack Interferon-\u03b3 or its receptor are highly susceptible to experimental autoimmune myocarditis."], "hard_negatives": ["Rapamycin delays aging in fruit flies.", "Rapamycin increases the concentration of triacylglycerols in fruit flies.", "Ethanol stress increases the expression of IBP in bacteria.", "Inside the body, falciparum parasites reproduce asexually.", "Progerin induces premature aging in stem cells.", "Autophagy deficiency in the liver increases vulnerability to insulin resistance.", "Omnivores produce less trimethylamine N-oxide from dietary I-carnitine than vegans.", "Omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegans.", "Omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegetarians.", "Sildenafil worsens erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants."], "hard_negative": "Rapamycin delays aging in fruit flies."}
{"query_id": "1016", "query_text": "Rapamycin increases the concentration of triacylglycerols in fruit flies.", "negative": "Monoclonal antibody targeting of N-cadherin inhibits growth.", "negatives": ["Monoclonal antibody targeting of N-cadherin inhibits growth.", "The tissue surrounding the granuloma in an immune cell induces an anti-inflammatory immune response.", "Cancer-associated fibroblasts (CAFs) interact with cancer cells to mediate formation and activation of CAFs.", "Increased flux of microbial products provokes immune responses.", "Upregulation of dynein in Drosophila neurons increases the number of microtubule plus-ends growing toward the cell body of each neuron.", "Incidence of sepsis has fallen substantially from 2009 to 2014.", "Increased vessel density along with a reduction in fibrosis improves the efficacy of chemotherapy treatments.", "Patients in stable partnerships have a slower progression from HIV to AIDS.", "The DESMOND program demonstrates no significant impact on biochemical outcomes.", "Approximately 250,000 people are infected with human T-cell lymphotropic virus type 1 in the United Kingdom."], "hard_negatives": ["Rapamycin increases the concentration of triacylglycerols in fruit flies.", "Rapamycin delays aging in fruit flies.", "Ethanol stress increases the expression of IBP in bacteria.", "Omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegetarians.", "Higher plasma levels of I-carnitine, when associated with trimethylamine N-oxide, are positively correlated with cardiovascular events in humans.", "Higher plasma levels of I-carnitine, when associated with trimethylamine N-oxide, are negatively correlated with cardiovascular events in humans.", "Omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegans.", "Omnivores produce less trimethylamine N-oxide from dietary I-carnitine than vegans.", "Sildenafil worsens erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.", "Oxidative DNA damage activates STING signalling."], "hard_negative": "Rapamycin increases the concentration of triacylglycerols in fruit flies."}
{"query_id": "1018", "query_text": "Rapid phosphotransfer rates are correlated with histidine kinase regulator specificity.", "negative": "V-9302 inhibits antitumor responses by decreasing cell death and oxidative stress.", "negatives": ["V-9302 inhibits antitumor responses by decreasing cell death and oxidative stress.", "Insulin decreases risk of severe kidney failure.", "Cancer-associated fibroblasts (CAFs) are constituents of tumor microenvironments", "p75 NTR - associated cell death executor (NADE) interacts with the p75 NTR death domain", "Removal of H3K9me3 improves reprogramming efficiency in human somatic cell nuclear transfer experiments.", "Diabetes remission occurs less in people treated with conventional therapy than in people treated with laparoscopic adjustable gastric banding surgery.", "Forkhead 0 (fox0) transcription factors are involved in apoptosis.", "The DEXI promoter region is bound by multiple transcription factors in a murine haematopoietic progenitor cell line.", "Pioneer factor OCT3/4 interacts with major chromatin remodeling factors.", "Patients with panic anxiety show decreased CSF levels of hypocretin."], "hard_negatives": ["Rapid phosphotransfer rates are correlated with histidine kinase regulator specificity.", "Increased lipolysis leads to higher P38 phosphorylation in adipose tissue.", "Reduced levels of lipolysis leads to higher P38 phosphorylation in adipose tissue.", "Ethanol stress lowers the expression of PSP in bacteria.", "Low nucleosome occupancy correlates with high methylation levels across species.", "Ethanol stress increases the expression of PSP in bacteria.", "H4 G94P proteins induce degradation of free histones via Rad53-dependent mechanisms.", "H4 G94P proteins induce chromatin assembly, which increases free histones.", "A deficiency of folate increases blood levels of homocysteine.", "Oxidative phosphorylation is one of the primary glycometabolic pathways in cells."], "hard_negative": "Rapid phosphotransfer rates are correlated with histidine kinase regulator specificity."}
{"query_id": "1023", "query_text": "Recognition of start codons depends on the translation initiation factor IF3.", "negative": "Patients with common epithelial cancers  are more likely to have an emergency event as their first hospital admission if they live in resource-deprived areas.", "negatives": ["Patients with common epithelial cancers  are more likely to have an emergency event as their first hospital admission if they live in resource-deprived areas.", "70% of burn patients are admitted for hospitalization and further treatment after appearing at hospital emergency wards or outpatient clinics.", "GATA3 regulates self-renewal capacity in bone marrow hematopoietic stem cells.", "Chemical injury represses transglutaminase 2 activity.", "HOXB4 is a highly expressed component of cellular secretome from fetal liver cell populations.", "Radioiodine treatment of non-toxic multinodular goitre increases thyroid volume.", "Replacement of histone H2A with H2A.Z accelerates gene activation in yeasts by destabilizing +1 nucleosomes.", "Chenodeoxycholic acid treatment decreases brown adipose tissue activity.", "Perigenital skin is not the primary site of HIV acquisition.", "Formation of N-terminal pyroglutamate by glutamine cyclase (GC) competes with NTAQ1 for Nt-Gln substrates."], "hard_negatives": ["Recognition of start codons depends on the translation initiation factor IF3.", "mcm 5 s 2 U is required for proper decoding of NNR codons in eukaryotes.", "Transcription rates in S. cerevisiae range between 0.7 and 2 kb/min.", "Transcription rates in S. cerevisiae range between 7 and 12 kb/min.", "IFIT1 speeds viral replication by allowing for the proliferation of mis-capped viral RNAs.", "The repeat-variable diresidue (RVD) in the loop of Transcription-Activator Like (TAL) effectors specifies the nucleotides-amino acid contact at the target promoter element.", "Cytochrome c is transferred from cytosol to the mitochondrial intermembrane space during apoptosis.", "Trans-acting factors, such as lncRNAs, influence mRNA translation.", "Most termination events in Okazaki fragments are dictated by initiation patterns.", "miRNAs enforce homeostasis by suppressing low-level ''leaky'' transcription."], "hard_negative": "Recognition of start codons depends on the translation initiation factor IF3."}
{"query_id": "1025", "query_text": "Reduced levels of lipolysis leads to higher P38 phosphorylation in adipose tissue.", "negative": "Ethanol stress increases the expression of IBP in bacteria.", "negatives": ["Ethanol stress increases the expression of IBP in bacteria.", "Expression of oncolytic virus antigens as peptides makes relapse more likely.", "The appearance of brown-like or beige cells primarily occurs in visceral fat, not subcutaneous fat.", "Mitochondria play a major role in energy production.", "ScPif1p has reduced binding ability to G-rich ssDNA compared to non-G-rich ssDNA.", "Klf4 is not required for proper myeloid cell differentiation.", "Upregulation of dynein in Drosophila neurons increases the number of microtubule plus-ends growing toward the cell body of each neuron.", "Osteocytes have an essential role in G-CSF induced HSPC mobilization.", "Drosophila supracellular actomyosin structures are found at boundaries in wing imaginal discs.", "One in two surgical randomized controlled trials are discontinued early."], "hard_negatives": ["Reduced levels of lipolysis leads to higher P38 phosphorylation in adipose tissue.", "Increased lipolysis leads to higher P38 phosphorylation in adipose tissue.", "Inhibiting glucose-6-phospate dehydrogenase improves lipogenesis by deactivating LKB1-AMPK signaling.", "AMP-activated protein kinase (AMPK) activation reduces inflammation-related fibrosis in the lungs.", "Chenodeoxycholic acid treatment increases brown adipose tissue activity.", "APOE4 expression in iPSC-derived neurons results in decreased tau phosphorylation.", "Chenodeoxycholic acid treatment decreases brown adipose tissue activity.", "The M2-phenotype in brown adipose tissue macrophages increases brown adipose tissue thermogenic activity.", "The morphology change from large white adipocytes to small brown adipocytes is a sign of decreased energy expenditure potential in white adipose tissue.", "The morphology change from large white adipocytes to small brown adipocytes is a sign of increased energy expenditure potential in white adipose tissue."], "hard_negative": "Reduced levels of lipolysis leads to higher P38 phosphorylation in adipose tissue."}
{"query_id": "1026", "query_text": "Reduced phosphorylation of PP2A increases HDAC4 dephosphorylation by enhancing PP2A-HDAC4 interaction.", "negative": "Depletion of nitric oxide is responsible for vasospasm.", "negatives": ["Depletion of nitric oxide is responsible for vasospasm.", "B3-Galectin increases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR.", "Rising temperatures caused by global warming increases risk of dengue fever transmission.", "ScPif1p has reduced binding ability to G-rich ssDNA compared to non-G-rich ssDNA.", "Dscam1 acts as a hypervariable pattern-recognition receptor for the immune system.", "NR5A2 is important in reverse cholesterol transport in humans.", "Aged patients are less susceptible to ischaemia/reperfusion injury.", "Pioglitazone use is significantly associated with an increased risk of pancreatic cancer.", "Exposure to fine particulate air pollution is unrelated to anxiety prevalence.", "Rotator cuff exercises are more effective than general exercise therapy in reducing pain and improving function of the shoulder."], "hard_negatives": ["Reduced phosphorylation of PP2A increases HDAC4 dephosphorylation by enhancing PP2A-HDAC4 interaction.", "Reduced phosphorylation of PP2A suppresses HDAC4 dephosphorylation.", "p16INK4A degradation is encoded by CDKN2A.", "C2 works synergistically with A-769662 to activate dephosphorylated AMPK.", "BCL-2 activation antagonizes the apoptotic effects of c-Myc.", "BCL-2 promotes the apoptotic effects of c-Myc.", "DUSP4 downregulation deactivates the Ras-ERK pathway", "Inhibiting glucose-6-phospate dehydrogenase improves lipogenesis by deactivating LKB1-AMPK signaling.", "Reduced levels of lipolysis leads to higher P38 phosphorylation in adipose tissue.", "PCSK9 inhibitors decrease plasma Lp(a) levels."], "hard_negative": "Reduced phosphorylation of PP2A increases HDAC4 dephosphorylation by enhancing PP2A-HDAC4 interaction."}
{"query_id": "1027", "query_text": "Reduced phosphorylation of PP2A suppresses HDAC4 dephosphorylation.", "negative": "A high microerythrocyte count protects against severe anemia in homozygous alpha (+)- thalassemia trait subjects.", "negatives": ["A high microerythrocyte count protects against severe anemia in homozygous alpha (+)- thalassemia trait subjects.", "miR-142-5P is a known regulator of raised body temperature.", "Autophagy deficiency in the liver increases vulnerability to insulin resistance.", "Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection increases dissemination of Salmonella Typhimurium from the gut.", "Anthrax spores are very difficult to dispose once they are dispersed.", "RA activation of DIF2 and NB4 cells induces hallmarks of transcriptionally active promoters.", "The proportion of people with visual difficulty is two times higher in low-income countries than in high-income countries.", "Side effects associated with antidepressants do not represent a mortality risk to postmenopausal women.", "Long chain polyunsaturated fatty acids supplementation reduces wheezing and asthma.", "Primary cervical cancer screening with HPV detection has lower longitudinal sensitivity than conventional cytology to detect cervical intraepithelial neoplasia grade 2."], "hard_negatives": ["Reduced phosphorylation of PP2A suppresses HDAC4 dephosphorylation.", "Reduced phosphorylation of PP2A increases HDAC4 dephosphorylation by enhancing PP2A-HDAC4 interaction.", "p16INK4A degradation is encoded by CDKN2A.", "C2 works synergistically with A-769662 to activate dephosphorylated AMPK.", "BCL-2 activation antagonizes the apoptotic effects of c-Myc.", "DUSP4 downregulation deactivates the Ras-ERK pathway", "DUSP4 increases apoptosis.", "DUSP4 decreases apoptosis.", "Activation of PPM1D enhances p53 function.", "BCL-2 promotes the apoptotic effects of c-Myc."], "hard_negative": "Reduced phosphorylation of PP2A suppresses HDAC4 dephosphorylation."}
{"query_id": "1028", "query_text": "Reduced responsiveness to interleukin-2 in regulatory T cells is associated with autoimmune diseases such as Type 1 Diabetes.", "negative": "Up-regulation of the p53 pathway and related molecular events speeds cancer progression.", "negatives": ["Up-regulation of the p53 pathway and related molecular events speeds cancer progression.", "Increased flux of microbial products suppresses immune responses.", "Lack of FGF21 in mice increases life expectancy.", "Major vault protein regulates sorting of tumor suppressive miR-193a into EVs.", "Taking 400mg of \u03b1-tocopheryl acetate does not prevent prostate cancer.", "Diabetes remission occurs less in people treated with conventional therapy than in people treated with laparoscopic adjustable gastric banding surgery.", "Ectopic expression of Sall4, Nanog, Esrrb, and Lin28 generates induced pluripotent stem cells from mouse embryonic fibroblasts more efficiently than other factor combinations.", "Chlamydia trachomatis is most prevalent in the UK among sexually-experienced individuals aged 16 to 24.", "Omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegans.", "Neutrophil extracellular trap (NET) antigens may contain the targeted autoantigens PR3 and MPO."], "hard_negatives": ["Reduced responsiveness to interleukin-2 in regulatory T cells is associated with autoimmune diseases such as Type 1 Diabetes.", "IL-10 production by monocytes inhibits CD4 + T cell response.", "Major antigen-induced signals from the T cell receptor and secondary signals from costimulatory receptors are required for T cell activation.", "Type 1 Diabetes is associated with subtle perturbations in T reg development.", "CD28 signals regulate trafficking of murine auto-reactive T cells into target tissues.", "Foxk2 regulates autophagy genes in muscle cells and fibroblast cells.", "Egr2 regulates the homeostasis of B and T cells.", "Foxp3 represses the expression of transcriptional regulators implicated in memory T cell development.", "Egr3 regulates the homeostasis of B and T cells.", "Foxp3 enables the expression of transcriptional regulators implicated in memory T cell development."], "hard_negative": "Reduced responsiveness to interleukin-2 in regulatory T cells is associated with autoimmune diseases such as Type 1 Diabetes."}
{"query_id": "1030", "query_text": "Reducing H3k4me3 methylation induces mouse epiblast stem cells to naive pluripotency efficiently.", "negative": "Tumor development occurs in conjunction with suppression of pro-inflammatory cytokines.", "negatives": ["Tumor development occurs in conjunction with suppression of pro-inflammatory cytokines.", "Misunderstandings between doctors and patients can lead to non-adherence.", "Fibroblast growth factor 21 protects against atherosclerosis by modulating adiponectin and SREBP2 levels.", "TNFAIP3 is a tumor enhancer in glioblastoma.", "7-day-old adult Caenorhabditis elegans exhibit approximately 5% of the learning capacity seen in 1-day old adults.", "General exercise therapy is more effective than rotator cuff exercises in reducing pain and improving function of the shoulder.", "One in two surgical randomized controlled trials are discontinued early.", "COPI coatmer is involved in viral replication.", "The predominant localization of Linc00173 is in mononuclear macrophage nuclei.", "Alteration of origin firing causes changes in termination zones of Okazaki fragments."], "hard_negatives": ["Reducing H3k4me3 methylation induces mouse epiblast stem cells to naive pluripotency efficiently.", "Removal of H3K9me3 by ectopic expression of other H3K9 demethylases improves reprogramming efficiency in SCNT experiments.", "Removal of H3K9me3 by ectopic expression of other H3K9 demethylases decreases reprogramming efficiency in SCNT experiments.", "Removal of H3K9me3 improves reprogramming efficiency in human somatic cell nuclear transfer experiments.", "MEK inhibitors are effective treatments in RAS-driven mouse models of cancer.", "Reduction of Rpl38 alters the composition of the Hox gene mRNAs translation in mice without lowering overall protein synthesis.", "H4 G94P proteins induce degradation of free histones via Rad53-dependent mechanisms.", "Foxp3 enables the expression of transcriptional regulators implicated in memory T cell development.", "p16INK4A degradation is encoded by CDKN2A.", "H4 G94P proteins suppress degradation of free histones via Rad53-dependent mechanisms."], "hard_negative": "Reducing H3k4me3 methylation induces mouse epiblast stem cells to naive pluripotency efficiently."}
{"query_id": "1031", "query_text": "Reduction of Rpl38 alters the composition of the Hox gene mRNAs translation in mice without lowering overall protein synthesis.", "negative": "Thiopurine active metabolites can be catabolized through dephosphorylation of thioguanine nucleotides.", "negatives": ["Thiopurine active metabolites can be catabolized through dephosphorylation of thioguanine nucleotides.", "Tirasemtiv targets cardiac muscle.", "Lmna knock-in models are appropriate for testing therapeutic approaches against Hutchinson-Gilford progeria syndrome (HGPS).", "Nonhypertensive people who are 55 years old have a 90% chance of developing hypertension during their lifetime.", "MafA phosphorylation enhances its ubiquitination.", "MICAL redox enzymes regulate actin dynamics in many cell types.", "Tirasemtiv targets fast-twitch muscle.", "HSCT-T dosage may not be diagnostic if the onset of symptoms occurs less than 3 hours before AMI.", "The one-child policy has created a hospitable environment for female infants.", "HNF4A mutations are associated with macrosomia in infancy."], "hard_negatives": ["Reduction of Rpl38 alters the composition of the Hox gene mRNAs translation in mice without lowering overall protein synthesis.", "Removal of H3K9me3 by ectopic expression of other H3K9 demethylases decreases reprogramming efficiency in SCNT experiments.", "Removal of H3K9me3 by ectopic expression of other H3K9 demethylases improves reprogramming efficiency in SCNT experiments.", "Reducing H3k4me3 methylation induces mouse epiblast stem cells to naive pluripotency efficiently.", "DUSP4 downregulation deactivates the Ras-ERK pathway", "Reduced levels of lipolysis leads to higher P38 phosphorylation in adipose tissue.", "Activation of PPM1D enhances p53 function.", "The G34R/V mutation does not create a hypomethylated phenotype at the H3K36 histone.", "Increased lipolysis leads to higher P38 phosphorylation in adipose tissue.", "The G34R/V mutation creates a hypomethylated phenotype at the H3K36 histone."], "hard_negative": "Reduction of Rpl38 alters the composition of the Hox gene mRNAs translation in mice without lowering overall protein synthesis."}
{"query_id": "1032", "query_text": "Reduction of purity of cytoplasmic membranes isolated from overexpressors is indicated by stronger spots for OmpA in 2D BN-PAGE gels.", "negative": "Mutations in RIM1 decrease levels of IME1 RNA.", "negatives": ["Mutations in RIM1 decrease levels of IME1 RNA.", "Cnn1 recruitment varies with cell cycle timing.", "YAP/TAZ is required in intestinal regeneration in mouse models of ulcerative colitis.", "Clathrin stabilizes the spindle fiber apparatus during mitosis.", "Folate and vitamin B12 levels influence the association between homocysteine and preeclampsia.", "Women are more susceptible to death due to pneumonia when compared to men.", "Increased purity of cytoplasmic membranes isolated from overexpressors is indicated by stronger spots for OmpF in 2D BN-PAGE gels.", "Induced hepatic stem cells possess the potential to differentiate into hepatocytic cells.", "In British Men, haplogroup I increases risk of cardiovascular disease by 50%.", "G-CSF increases the expansion and infiltration of MDSCs into tumors."], "hard_negatives": ["Reduction of purity of cytoplasmic membranes isolated from overexpressors is indicated by stronger spots for OmpA in 2D BN-PAGE gels.", "Reduction of purity of cytoplasmic membranes isolated from overexpressors is indicated by stronger spots for OmpF in 2D BN-PAGE gels.", "Increased purity of cytoplasmic membranes isolated from overexpressors is indicated by stronger spots for OmpF in 2D BN-PAGE gels.", "Lamins have no effect on nuclear membrane structure maintenance.", "Intramembrane cleavage by signal peptide peptidase aids in the degradation of proteins with a complex membrane orientation.", "The microtubule-dependent delivery and secretion of matrix metalloproteases (MMPs) is partially responsible for the disassembly of adhesion sites.", "Many transmembrane receptors transmit signals by long-range conformational changes in the association of alpha-helices across the plasma membrane.", "Mice defective for deoxyribonucleic acid (DNA) polymerase m (polm) fail to reveal increased sensitivity to ionizing radiation (IR).", "Lamins are associated with nuclear membrane structure maintenance.", "Mice defective for deoxyribonucleic acid (DNA) polymerase m (polm) reveal increased sensitivity to ionizing radiation (IR)."], "hard_negative": "Reduction of purity of cytoplasmic membranes isolated from overexpressors is indicated by stronger spots for OmpA in 2D BN-PAGE gels."}
{"query_id": "1033", "query_text": "Reduction of purity of cytoplasmic membranes isolated from overexpressors is indicated by stronger spots for OmpF in 2D BN-PAGE gels.", "negative": "Antidepressants reduce the severity of migraines.", "negatives": ["Antidepressants reduce the severity of migraines.", "Transplanted human glial progenitor cells can mature in their host animal.", "Diabetes remission occurs more in people treated with conventional therapy than in people treated with laparoscopic adjustable gastric banding surgery.", "The DESMOND program caused substantial weight loss in most participants.", "Osteocytes have an essential role in G-CSF induced HSPC mobilization.", "Activated Cdk5 phosphorylates the ATM protein in response to DNA damage.", "Varying expression levels of EBI2 affect the positioning and migration of B cells.", "Incidence of 10/66 dementia is higher than the incidence of DSM-IV dementia.", "The relationship between a breast cancer patient's capacity to metabolize tamoxifen and treatment outcome is independent of the patient's genetic make-up.", "Mutations in G-Beta protein GNB1 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway."], "hard_negatives": ["Reduction of purity of cytoplasmic membranes isolated from overexpressors is indicated by stronger spots for OmpF in 2D BN-PAGE gels.", "Increased purity of cytoplasmic membranes isolated from overexpressors is indicated by stronger spots for OmpF in 2D BN-PAGE gels.", "Reduction of purity of cytoplasmic membranes isolated from overexpressors is indicated by stronger spots for OmpA in 2D BN-PAGE gels.", "Intramembrane cleavage by signal peptide peptidase aids in the degradation of proteins with a complex membrane orientation.", "The microtubule-dependent delivery and secretion of matrix metalloproteases (MMPs) is partially responsible for the disassembly of adhesion sites.", "Lamins have no effect on nuclear membrane structure maintenance.", "Many transmembrane receptors transmit signals by long-range conformational changes in the association of alpha-helices across the plasma membrane.", "Mice defective for deoxyribonucleic acid (DNA) polymerase m (polm) fail to reveal increased sensitivity to ionizing radiation (IR).", "\u03b21/Ketel is able to bind microtubules.", "Broadly HIV-1 Neutralizing Antibodies (bnAb) 10EB have no affinity for phospholipids."], "hard_negative": "Reduction of purity of cytoplasmic membranes isolated from overexpressors is indicated by stronger spots for OmpF in 2D BN-PAGE gels."}
{"query_id": "1034", "query_text": "Removal of H3K9me3 by ectopic expression of other H3K9 demethylases decreases reprogramming efficiency in SCNT experiments.", "negative": "Intramembrane cleavage by signal peptide peptidase aids in the degradation of proteins with a complex membrane orientation.", "negatives": ["Intramembrane cleavage by signal peptide peptidase aids in the degradation of proteins with a complex membrane orientation.", "Bariatric surgery leads to positive outcomes in mental health.", "The myocardial cell lineage originally develops from cardiac progenitors of exclusively endodermal origin.", "Mitochondria play a major role in energy production.", "Occipital activation levels are associated with auditory spatial performance in parietal regions of the brain.", "Osteoparthritis (OA) is characterized by degeneration of articular cartilage, joint edge, and subchondral bone hyperplasia.", "The DESMOND program caused substantial weight loss in most participants.", "MEK inhibitors are effective treatments in RAS-driven mouse models of cancer.", "The proportion of people with visual difficulty is two times higher in low-income countries than in high-income countries.", "Patients in stable partnerships progress from HIV to death at the same rate as patients not in partnerships."], "hard_negatives": ["Removal of H3K9me3 by ectopic expression of other H3K9 demethylases improves reprogramming efficiency in SCNT experiments.", "Removal of H3K9me3 by ectopic expression of other H3K9 demethylases decreases reprogramming efficiency in SCNT experiments.", "Removal of H3K9me3 improves reprogramming efficiency in human somatic cell nuclear transfer experiments.", "Reducing H3k4me3 methylation induces mouse epiblast stem cells to naive pluripotency efficiently.", "H4 G94P proteins induce degradation of free histones via Rad53-dependent mechanisms.", "Inhibiting glucose-6-phospate dehydrogenase improves lipogenesis by deactivating LKB1-AMPK signaling.", "H4 G94P proteins suppress degradation of free histones via Rad53-dependent mechanisms.", "The G34R/V mutation does not create a hypomethylated phenotype at the H3K36 histone.", "JMJD6 slows the hydroxylation of C-terminal lysine", "The G34R/V mutation creates a hypomethylated phenotype at the H3K36 histone."], "hard_negative": "Removal of H3K9me3 by ectopic expression of other H3K9 demethylases improves reprogramming efficiency in SCNT experiments."}
{"query_id": "1035", "query_text": "Removal of H3K9me3 by ectopic expression of other H3K9 demethylases improves reprogramming efficiency in SCNT experiments.", "negative": "Female carriers of the Apolipoprotein E4 (APOE4) allele have longer lifetime exposure to estrogen due to an increased reproductive period.", "negatives": ["Female carriers of the Apolipoprotein E4 (APOE4) allele have longer lifetime exposure to estrogen due to an increased reproductive period.", "Long chain polyunsaturated fatty acids supplementation reduces wheezing and asthma.", "Deletion of ATM and Rad3 related protein is not predictive of acute tissue loss.", "Pharmacist attendance at ward rounds increases adverse events in wards.", "VgrG (Tssl) protein punctures membranes by forming a spike at the tip of the tube apparatus.", "Having a main partner worsens HIV outcomes.", "Vitamin D is an important factor in the relationship between calcium and parathyroid hormone.", "Origin gross domestic product(GDP) is positively related to dengue virus (DENV-1) diffusion in air traffic shipments.", "Long - range chromatin interactions regulate transcription.", "F4/80+ macrophages regulate mature osteoblast maintenance."], "hard_negatives": ["Removal of H3K9me3 by ectopic expression of other H3K9 demethylases improves reprogramming efficiency in SCNT experiments.", "Removal of H3K9me3 by ectopic expression of other H3K9 demethylases decreases reprogramming efficiency in SCNT experiments.", "Removal of H3K9me3 improves reprogramming efficiency in human somatic cell nuclear transfer experiments.", "Reducing H3k4me3 methylation induces mouse epiblast stem cells to naive pluripotency efficiently.", "H4 G94P proteins induce degradation of free histones via Rad53-dependent mechanisms.", "Inhibiting glucose-6-phospate dehydrogenase improves lipogenesis by deactivating LKB1-AMPK signaling.", "H4 G94P proteins suppress degradation of free histones via Rad53-dependent mechanisms.", "The G34R/V mutation does not create a hypomethylated phenotype at the H3K36 histone.", "JMJD6 slows the hydroxylation of C-terminal lysine", "C2 works synergistically with A-769662 to activate dephosphorylated AMPK."], "hard_negative": "Removal of H3K9me3 by ectopic expression of other H3K9 demethylases improves reprogramming efficiency in SCNT experiments."}
{"query_id": "1036", "query_text": "Removal of H3K9me3 improves reprogramming efficiency in human somatic cell nuclear transfer experiments.", "negative": "Lack of FGF21 in mice slows the rate of atherosclerotic plaque formation.", "negatives": ["Lack of FGF21 in mice slows the rate of atherosclerotic plaque formation.", "PGE 2 suppresss intestinal tumor growth by altering the expression of tumor suppressing and DNA repair genes.", "The predominant localization of Linc00173 is in mononuclear macrophage nuclei.", "The DESMOND program demonstrates no significant impact on biochemical outcomes.", "Ribosome-inactivating protein-2 (RIP-2) interacts with the p75 NTR death domain", "COPI coatmer is involved in viral replication.", "The DESMOND program demonstrates no significant impact on biochemical outcomes.", "CCL19 is predominantly present within dLNs.", "Stiff substrates inhibit mesodermal differentiation by degrading beta-catenin in an integrin-dependent manner.", "PTEN is a regulator for the transcriptional activity of SRF"], "hard_negatives": ["Removal of H3K9me3 improves reprogramming efficiency in human somatic cell nuclear transfer experiments.", "Removal of H3K9me3 by ectopic expression of other H3K9 demethylases improves reprogramming efficiency in SCNT experiments.", "Removal of H3K9me3 by ectopic expression of other H3K9 demethylases decreases reprogramming efficiency in SCNT experiments.", "Reducing H3k4me3 methylation induces mouse epiblast stem cells to naive pluripotency efficiently.", "Activation of PPM1D enhances p53 function.", "H4 G94P proteins induce degradation of free histones via Rad53-dependent mechanisms.", "Cytochrome c is transferred from cytosol to the mitochondrial intermembrane space during apoptosis.", "Activated Cdk5 regulates DNA damage-induced neuronal death.", "H4 G94P proteins suppress degradation of free histones via Rad53-dependent mechanisms.", "Replacement of histone H2A with H2A.Z accelerates gene activation in yeasts by destabilizing +1 nucleosomes."], "hard_negative": "Removal of H3K9me3 improves reprogramming efficiency in human somatic cell nuclear transfer experiments."}
{"query_id": "1037", "query_text": "Replacement of OCT4 and SOX2 genes with GATA3 has the ability to reprogram human cells.", "negative": "Mitochondria play a major role in apoptosis.", "negatives": ["Mitochondria play a major role in apoptosis.", "Mice lacking Sirt1 in Sf1-expressing neurons have increased susceptibility to diet-induced obesity and insulin resistance.", "Tumor development occurs in conjunction with suppression of pro-inflammatory cytokines.", "The PRDM1 gene is a key determinant of primordial germ cells.", "GATA3 regulates cell cycle progression in bone marrow hematopoietic stem cells.", "Pseudoknots are not evolutionarily conserved in most eukaryotes.", "Decreased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm.", "The most prevalent adverse events to Semaglutide are cardiovascular.", "Tuberculosis-induced granulomas express different immune system protein signatures than the surrounding tissue.", "Pharmacist attendance at ward rounds increases adverse events in wards."], "hard_negatives": ["Replacement of OCT4 and SOX2 genes with GATA3 has the ability to reprogram human cells.", "Replacement of OCT4 and SOX2 genes with GATA3 is not capable of reprogramming human cells.", "In transgenic mice harboring green florescent protein under the control of the Sox2 promoter, more than 50 percent of the cells with green florescent colocalize with cell proliferation markers.", "ATM and Rad3 related protein have no role in sensing DNA damage.", "ATM and Rad3 related protein are critical for sensing DNA damage.", "Pioneer factor OCT3/4 interacts with major chromatin remodeling factors.", "There is no known interaction between Pioneer factor OCT3/4 and major chromatin remodeling factors.", "CD28 signals regulate trafficking of murine auto-reactive T cells into target tissues.", "Activated Cdk5 phosphorylates the ATM protein in response to DNA damage.", "HIV trans-activator protein (TAT) effectively transports large and small molecules across cellular membranes into larger populations of neurons."], "hard_negative": "Replacement of OCT4 and SOX2 genes with GATA3 has the ability to reprogram human cells."}
{"query_id": "1038", "query_text": "Replacement of OCT4 and SOX2 genes with GATA3 is not capable of reprogramming human cells.", "negative": "R2D2 stops miRNA production by increasing the selectivity of Dcr2 for long dsRNA.", "negatives": ["R2D2 stops miRNA production by increasing the selectivity of Dcr2 for long dsRNA.", "Ethanol stress increases the expression of PSP in bacteria.", "The minor G allele of FOXO3 up-regulates IL-10.", "Nonhuman primates are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.", "7-day-old adult Caenorhabditis elegans exhibit approximately 75% of the learning capacity seen in 1-day old adults.", "MafA ubiquitination increases the recruitment of coavtivator P/CAF by MafA.", "Primary pro-inflammatory cytokines suppress secondary pro- and anti-inflammatory mediators.", "Pyridostatin stabilizes the G - quadruplex in the telomeric region.", "De novo assembly of sequence data has shorter contigs than unassembled sequence data.", "Adult tissue-resident macrophages are seeded before birth."], "hard_negatives": ["Replacement of OCT4 and SOX2 genes with GATA3 is not capable of reprogramming human cells.", "Replacement of OCT4 and SOX2 genes with GATA3 has the ability to reprogram human cells.", "In transgenic mice harboring green florescent protein under the control of the Sox2 promoter, more than 50 percent of the cells with green florescent colocalize with cell proliferation markers.", "ATM and Rad3 related protein have no role in sensing DNA damage.", "ATM and Rad3 related protein are critical for sensing DNA damage.", "There is no known interaction between Pioneer factor OCT3/4 and major chromatin remodeling factors.", "Gpr124 suppresses BBB breakdown in mouse models of ischemic stroke.", "Deletion of ATM and Rad3 related protein is not predictive of acute tissue loss.", "Deletion of ATM and Rad3 related protein leads to acute tissue loss.", "In a naive state, blocking Wingless-Int-1 secretion from mouse embryonic stem cells inhibits self-renewal of the mouse embryonic stem cells."], "hard_negative": "Replacement of OCT4 and SOX2 genes with GATA3 is not capable of reprogramming human cells."}
{"query_id": "1040", "query_text": "Replacement of histone H2A with H2A.Z accelerates gene activation in yeasts by destabilizing +1 nucleosomes.", "negative": "Glycan adaptation is rarely observed in the B-cell repertoire.", "negatives": ["Glycan adaptation is rarely observed in the B-cell repertoire.", "Students who perform poorly in the early years of medical school are less likely to commit professional misconduct later in their careers.", "Patients in stable partnerships have a slower progression from HIV to AIDS.", "Angiotensin converting enzyme inhibitors are associated with decreased risk for functional renal insufficiency.", "Formation of N-terminal pyroglutamate by glutamine cyclase (GC) competes with NTAQ1 for Nt-Gln substrates.", "Immune complex triggered cell death leads to sequestration of oxidized mitochondrial DNA.", "CD28 signals regulate trafficking of murine auto-reactive T cells into target tissues.", "KRT17 modulates the expression of the transcriptional regulator AIRE in diseased epithelia.", "Cardiac tissue-resident macrophages directly contribute to electrical activity.", "Pre-mRNAs associated with spliceosomal components are more stable than unassociated splicing substrates."], "hard_negatives": ["Replacement of histone H2A with H2A.Z accelerates gene activation in yeasts by destabilizing +1 nucleosomes.", "H4 G94P proteins induce degradation of free histones via Rad53-dependent mechanisms.", "H4 G94P proteins induce chromatin assembly, which increases free histones.", "H4 G94P proteins suppress degradation of free histones via Rad53-dependent mechanisms.", "H4 G94P proteins inhibit chromatin assembly, which decreases free histones.", "Formation of N-terminal pyroglutamate by glutamine cyclase (GC) competes with NTAQ1 for Nt-Gln substrates.", "The H2A-H2B eviction defect is compensated for by other histone chaperone(s).", "FACT and other histone chaperone(s) compensate for Histone 2A (H2A)-histone 2B (H2B) dimer eviction during the histone exchange process.", "The Snf1 complex regulates carbon and energy metabolism in baker's yeast (Saccharomyces cerevisiae).", "The deamination of cytidine to uridine on the minus strand of viral DNA can inactivate the viral genome by inducing G-to-A mutations."], "hard_negative": "Replacement of histone H2A with H2A.Z accelerates gene activation in yeasts by destabilizing +1 nucleosomes."}
{"query_id": "1042", "query_text": "Repressing IL-18 has negative effects on atherosclerotic lesion composition and progression.", "negative": "CCL19 is predominantly present within dLNs.", "negatives": ["CCL19 is predominantly present within dLNs.", "The morphology change from large white adipocytes to small brown adipocytes is a sign of increased energy expenditure potential in white adipose tissue.", "H4 G94P proteins suppress degradation of free histones via Rad53-dependent mechanisms.", "Pyridostatin stabilizes the G - quadruplex in the telomeric region.", "Fibroblast Growth Factor is a ligand which signals through receptor tyrosine kinases.", "Cyclin A2 destruction is necessary to switch from unstable to stable kt-mt attachments in mitosis.", "Major vault protein (MVP) leads to more aggressive tumors by regulating the sorting of tumor suppressive miR-193a into extracellular vesicles (EVs).", "Patients with common epithelial cancers  are more likely to have an emergency event as their first hospital admission if they live in resource-deprived areas.", "Varenicline monotherapy is more effective after 26 weeks of treatment compared to combination nicotine replacement therapies with varenicline or bupropion.", "Gastric infection with Helicobacter pylori increases risk of gastric cancer in humans."], "hard_negatives": ["Repressing IL-18 has negative effects on atherosclerotic lesion composition and progression.", "Interleukin-18 plays an important role in the pathogenesis of atherosclerosis.", "IL-6 signaling plays a major role in atherosclerotic cardiovascular disease.", "PD-1 triggering on monocytes enhances IL-10 production by monocytes.", "p16INK4A degradation is  linked to an abnormal wound response caused by the microinvasive step of advanced Oral Potentially Malignant Lesions (OPMLs).", "Neutrophils produce IL-1\u03b2 in response to large particles.", "Certain immunomodulator-human dialyzable leukocyte extract (hDLE) peptides are recognized by toll-like receptors (TLRs) on macrophages and dendritic cells.", "IL-10 production by monocytes inhibits CD4 + T cell response.", "Monoclonal antibody targeting of N-cadherin encourages metastasis.", "The minor G allele of FOXO3 up-regulates IL-10."], "hard_negative": "Repressing IL-18 has negative effects on atherosclerotic lesion composition and progression."}
{"query_id": "1043", "query_text": "Retinoic acid receptor-related orphan receptor gamma (ROR\u03b3) is a therapeutic target for castration-resistant prostate cancer (CRPC)", "negative": "The tissue surrounding the granuloma in an immune cell induces an anti-inflammatory immune response.", "negatives": ["The tissue surrounding the granuloma in an immune cell induces an anti-inflammatory immune response.", "Long - range chromatin interactions regulate transcription.", "CD28 initiates tonic signaling in conventional T cells, which causes an exhaustion phenotype and limited efficiency.", "Less than 10% of patients exposed to radiation have activated markers of mesenchymal stem cells.", "The combination of physical examinations with C-reactive protein values do not improve the accuracy of radiographic verified pneumonia predictions.", "In chronic viral infections or tumors, peptides that selectively inhibit PTPRS can be utilized to boost insufficient activity of pDCs.", "High levels of CRP lead to a higher risk of exacerbations in chronic obstructive pulmonary disease (COPD).", "Clathrin stabilizes the spindle fiber apparatus during mitosis.", "Gastric infection with Helicobacter pylori decreases risk of gastric cancer in humans.", "Natriuretic peptides increase susceptibility to diabetes."], "hard_negatives": ["Retinoic acid receptor-related orphan receptor gamma (ROR\u03b3) is a therapeutic target for castration-resistant prostate cancer (CRPC)", "TNFAIP3 is a glioblastoma tumor suppressor.", "TNFAIP3 is a glioblastoma tumor enhancer.", "TNFAIP3 is a tumor enhancer in glioblastoma.", "Cancers that initially benefit from epidermal growth factor receptor targeted therapies later become refractory through several mechanisms.", "The NF-\u03baB essential modulator gene prevents intestinal inflammation by inhibiting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death.", "LSD1-positive promoters are associated with RNA polymerase II", "The NF-\u03baB essential modulator gene induces intestinal inflammation by promoting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death.", "Pioglitazone use is not associated with an increased risk of prostate cancer.", "Cancer-associated fibroblasts (CAFs) have no known interaction with cancer cells in the formation and activation of CAFs."], "hard_negative": "Retinoic acid receptor-related orphan receptor gamma (ROR\u03b3) is a therapeutic target for castration-resistant prostate cancer (CRPC)"}
{"query_id": "1044", "query_text": "Rhythmic expression of Cry1 translates directly into a circadian regulation of cAMP signaling in gluconeogenesis.", "negative": "Mice are incapable of producing neutralizing antibodies in reponse to the Chikungunya virus (CHIKV) produced in mosquitos.", "negatives": ["Mice are incapable of producing neutralizing antibodies in reponse to the Chikungunya virus (CHIKV) produced in mosquitos.", "Nuclear transfer from adult human fibroblasts to human oocytes can give rise to blastocysts containing expandable pluripotent cells.", "Rapamycin delays aging in fruit flies.", "Varenicline monotherapy is more effective after 26 weeks of treatment compared to combination nicotine replacement therapies with varenicline or bupropion.", "Notch signaling occurs between tumor cells and stromal cells.", "Rhythmic expression of Cry1 translates directly into a circadian regulation of cAMP signaling in hepatic glucose metabolism.", "The DESMOND program demonstrates no significant impact on biochemical outcomes.", "ScPif1p has reduced binding ability to G-rich ssDNA compared to non-G-rich ssDNA.", "In rhesus macaques, daily subcutaneous injections of emtricitabine are ineffective at protecting against rectally transmitted simian-human immunodeficiency virus.", "Chlamydia trachomatis is most prevalent in the UK among individuals in their 50s and 60s."], "hard_negatives": ["Rhythmic expression of Cry1 translates directly into a circadian regulation of cAMP signaling in gluconeogenesis.", "Rhythmic expression of Cry1 translates directly into a circadian regulation of cAMP signaling in hepatic glucose metabolism.", "Increased lipolysis leads to higher P38 phosphorylation in adipose tissue.", "Binding of p53 to enhancer regions (p53BERs) regulates the activity of p53 transcription and cell cycle arrest through the production of p53-dependent eRNAs.", "Activation of PPM1D enhances p53 function.", "PKG-la does not have a large impact on expression of pain hypersensitivity in PGK-la knockout mice.", "Hypothalamic glutamate neurotransmission is unrelated to energy balance.", "Reduced levels of lipolysis leads to higher P38 phosphorylation in adipose tissue.", "Energy balance requires hypothalamic glutamate neurotransmission.", "Oxidative phosphorylation is one of the primary glycometabolic pathways in cells."], "hard_negative": "Rhythmic expression of Cry1 translates directly into a circadian regulation of cAMP signaling in gluconeogenesis."}
{"query_id": "1045", "query_text": "Rhythmic expression of Cry1 translates directly into a circadian regulation of cAMP signaling in hepatic glucose metabolism.", "negative": "siRNA knockdown of A20 slows tumor progression in an in vivo murine xenograft model.", "negatives": ["siRNA knockdown of A20 slows tumor progression in an in vivo murine xenograft model.", "PKG-la does not have a large impact on expression of spinal long term potentiation in PGK-la knockout mice.", "Obesity raises life quality.", "Tuberculosis incidence occurs at higher rates in more sparsely populated areas in the UK.", "Formation of N-terminal pyroglutamate by glutamine cyclase (GC) competes with NTAQ1 for Nt-Gln substrates.", "A deficiency of vitamin B6 decreases blood levels of homocysteine.", "In rhesus macaques, daily subcutaneous injections of tenofovir protects against rectally transmitted simian-human immunodeficiency virus.", "Urbanization is an important risk factor related to the transmission of dengue fever.", "Destination container port throughput(CPT) is negatively related to dengue virus (DENV-1) diffusion in air traffic shipments.", "Differentiation of progenitor cells to myeloid cells is skewed when insulin signaling is suppressed."], "hard_negatives": ["Rhythmic expression of Cry1 translates directly into a circadian regulation of cAMP signaling in hepatic glucose metabolism.", "Rhythmic expression of Cry1 translates directly into a circadian regulation of cAMP signaling in gluconeogenesis.", "Increased lipolysis leads to higher P38 phosphorylation in adipose tissue.", "Reduced levels of lipolysis leads to higher P38 phosphorylation in adipose tissue.", "Hypothalamic glutamate neurotransmission is unrelated to energy balance.", "Energy balance requires hypothalamic glutamate neurotransmission.", "The Snf1 complex regulates carbon and energy metabolism in baker's yeast (Saccharomyces cerevisiae).", "Activation of PPM1D enhances p53 function.", "Ethanol stress increases the expression of PSP in bacteria.", "Ethanol stress lowers the expression of PSP in bacteria."], "hard_negative": "Rhythmic expression of Cry1 translates directly into a circadian regulation of cAMP signaling in hepatic glucose metabolism."}
{"query_id": "1046", "query_text": "Ribosomal protein (RP) expression is controlled in part by stress-activated regulators.", "negative": "N348I mutations reduce resistance to nevirapine.", "negatives": ["N348I mutations reduce resistance to nevirapine.", "In melanoma, anti-CTLA-4 treatment reinvigorates exhausted PD-1+Eomes+CD8 T cells.", "Osteocytes have an essential role in G-CSF induced HSPC mobilization.", "Ribosome-inactivating protein-2 (RIP-2) interacts with the p75 NTR death domain", "Commelina yellow mottle virus (ComYMV) has three typical badnavirus ORFs, capable of encoding proteins 23, 15, and 216 kD.", "The generation of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells.", "RAD52 is involved in break-induced DNA replication (BIR).", "Malaria has a high vectorial capacity.", "H.pylori-mediated gastric cancer occurs due to the accumulation of mutations in host epithelial cells.", "Increased conversion of PGE 2 to PPARy ligand 15-ket-PGE 2 causes accumulation of PGE."], "hard_negatives": ["Ribosomal protein (RP) expression is controlled in part by stress-activated regulators.", "BiP is a general endoplasmic reticulum stress marker.", "miRNAs regulate a unique suite of mRNAs to maintain homeostasis in cells.", "ATF4 is a general endoplasmic reticulum stress marker.", "Lack of FGF21 in mice increases life expectancy.", "Lack of FGF21 in mice leads to reduced lifespan.", "Rhythmic expression of Cry1 translates directly into a circadian regulation of cAMP signaling in gluconeogenesis.", "Ethanol stress increases the expression of SRL in bacteria.", "Mice lacking Sirt1 in Sf1-expressing neurons are immune to diet-induced obesity and insulin resistance.", "CD28 signals regulate trafficking of murine auto-reactive T cells into target tissues."], "hard_negative": "Ribosomal protein (RP) expression is controlled in part by stress-activated regulators."}
{"query_id": "1047", "query_text": "Ribosome-inactivating protein-2 (RIP-2) interacts with the p75 NTR death domain", "negative": "Taking 400mg of \u03b1-tocopheryl acetate does not prevent prostate cancer.", "negatives": ["Taking 400mg of \u03b1-tocopheryl acetate does not prevent prostate cancer.", "40mg/day dosage of folic acid and 2mg/day dosage of vitamin B12 does not affect chronic kidney disease (CKD) progression.", "Low expression of miR7a does not repress target genes or exert a biological function in ovaries.", "Prescribed exercise training improves quality of life.", "50% of patients exposed to radiation have activated markers of mesenchymal stem cells.", "Chlamydia trachomatis is most prevalent in the UK among sexually-experienced individuals aged 16 to 24.", "BCL-2 promotes the apoptotic effects of c-Myc.", "In S. cerevisiae, the absence of RNA surveillance pathways reduces sensitivity to high iron conditions.", "HNF4A mutations are associated with macrosomia in infancy.", "Propriospinal interneurons that play a role in the plastic reorganization of spinal circuits are integral for recovery from spinal cord injury."], "hard_negatives": ["Ribosome-inactivating protein-2 (RIP-2) interacts with the p75 NTR death domain", "p75 NTR - associated cell death executor (NADE) interacts with the p75 NTR death domain", "Guanine nucleotide dissociation inhibitor (Rho-GDI) interacts with the p75 NTR death domain", "Formation of N-terminal pyroglutamate by glutamine cyclase (GC) competes with NTAQ1 for Nt-Gln substrates.", "The NF-\u03baB essential modulator gene induces intestinal inflammation by promoting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death.", "The NF-\u03baB essential modulator gene prevents intestinal inflammation by inhibiting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death.", "MUC1-C activates the NF-\u03baB p65 signaling pathway by interacting with I\u03baB kinase \u00df.", "Smc5/6 engagment halts the activation of SUMO E3 ligase Mms21 by ATP-dependent remolding.", "5'-nucleotidase metabolizes 6MP.", "RAD52 is involved in break-induced DNA replication (BIR)."], "hard_negative": "Ribosome-inactivating protein-2 (RIP-2) interacts with the p75 NTR death domain"}
{"query_id": "1048", "query_text": "Ribosomopathies have a high degree of cell and tissue specific pathology.", "negative": "Aggravated inflammation is dependent on NLRP3 inflammasome activation.", "negatives": ["Aggravated inflammation is dependent on NLRP3 inflammasome activation.", "4-PBA treatment raises endoplasmic reticulum stress in response to general endoplasmic reticulum stress markers.", "Taxation of sugar-sweetened beverages reduced the incidence rate of type II diabetes in India.", "Perigenital skin is not the primary site of HIV acquisition.", "Citrullinated proteins externalized in neutrophil extracellular traps act indirectly to perpetuate the inflammatory cycle via induction of autoantibodies.", "The ability of activator E2Fs in preventing cell death is limited to terminally differentiated cells.", "Antidepressants increase the severity of migraines.", "Cytosolic proteins bind to iron-responsive elements on mRNAs coding for TFRC1.", "miRNAs regulate a unique suite of mRNAs to maintain homeostasis in cells.", "Ribosome-inactivating protein-2 (RIP-2) interacts with the p75 NTR death domain"], "hard_negatives": ["Ribosomopathies have a high degree of cell and tissue specific pathology.", "r-protein chaperones are found in complexes with their r-protein binding partners.", "Lamins are found within the inner layer of the mitochondrial membrane of all cells.", "Pseudoknots are not evolutionarily conserved in most eukaryotes.", "Pre-mRNAs associated with spliceosomal components are less stable than unassociated splicing substrates.", "Pre-mRNAs associated with spliceosomal components are more stable than unassociated splicing substrates.", "Cancer-associated fibroblasts (CAFs) are constituents of tumor microenvironments", "Glioblastoma multiforme (GBM) is characterized by extensive invasion, rapid growth, necrosis, and angiogenesis.", "Adult tissue-resident macrophages possess a self-renewing capacity.", "The latent infection of myeloid cells with human cytomegalovirus induces a number of changes in gene expression."], "hard_negative": "Ribosomopathies have a high degree of cell and tissue specific pathology."}
{"query_id": "1050", "query_text": "Risedronate increases risk of vertebral and non-vertebral fractures.", "negative": "COPI coatmer is involved in lipid homeostasis.", "negatives": ["COPI coatmer is involved in lipid homeostasis.", "KRT17 modulates the expression of the transcriptional regulator AIRE in diseased epithelia.", "Incidence of 10/66 dementia is higher than the incidence of DSM-IV dementia.", "Activation of PPM1D enhances p53 function.", "Activation of PPM1D enhances p53 function.", "IgA plasma cells that are specific for transglutaminase 2 are scarce in the duodenal mucosa of celiac disease patients when the disease is active.", "Surgical treatment is not superior to non-surgical in treating adults with displaced fractures of the proximal humerus.", "Deltex has no known interactions with eIF3f.", "CD28 signals regulate trafficking of murine auto-reactive T cells into target tissues.", "MafA ubiquitination decreases the recruitment of coavtivator P/CAF by MafA."], "hard_negatives": ["Risedronate increases risk of vertebral and non-vertebral fractures.", "Surgical treatment is not superior to non-surgical in treating adults with displaced fractures of the proximal humerus.", "Osteoparthritis (OA) is characterized by degeneration of articular cartilage, joint edge, and subchondral bone hyperplasia.", "Dexamethasone increases risk of postoperative bleeding.", "There is a positive correlation between hip fractures and statin use.", "There is no increased risk of hypospadias with clomiphene.", "The peak incidence of fractures occurs in toddlers.", "The peak incidence of fractures occurs during pubertal growth spurt in early adolescents.", "Sildenafil worsens erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.", "Radioiodine treatment of non-toxic multinodular goitre increases thyroid volume."], "hard_negative": "Risedronate increases risk of vertebral and non-vertebral fractures."}
{"query_id": "1052", "query_text": "Rising temperatures caused by global warming increases risk of dengue fever transmission.", "negative": "In melanoma, anti-CTLA-4 treatment reinvigorates exhausted PD-1+Eomes+CD8 T cells.", "negatives": ["In melanoma, anti-CTLA-4 treatment reinvigorates exhausted PD-1+Eomes+CD8 T cells.", "Ectopic expression of Sall4, Nanog, Esrrb, and Lin28 generates induced pluripotent stem cells from mouse embryonic fibroblasts more efficiently than other factor combinations.", "L3MBTL2 binds to H2AK119Ub marked chromatin to form a PRC1 complex.", "ART substantially reduces infectiveness of HIV-positive people.", "7-day-old adult Caenorhabditis elegans exhibit approximately 75% of the learning capacity seen in 1-day old adults.", "Chinese individuals with TT homozygosity in the MTHFR gene are less vulnerable to strokes caused by low levels of folate intake.", "ITAM phosphorylation allows for the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).", "The PRR MDA5 has a C-terminal domain.", "Lipopolysaccharides have an inflammation independent effect on kidney barrier function.", "The most prevalent adverse events to Semaglutide are gastrointestinal."], "hard_negatives": ["Rising temperatures caused by global warming increases risk of dengue fever transmission.", "Rising temperatures caused by global warming lowers the risk of dengue fever transmission.", "Urbanization is an important risk factor related to the transmission of dengue fever.", "Malaria has a high vectorial capacity.", "There was an estimated 30 million cases of pneumonia in young children worldwide in 2010.", "Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission.", "The World Health Organization's (WHO) data collection process is biased downward by unequal selection of larger outbreaks.", "Eilat virus (EILV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in nonhuman primates.", "The latent infection of myeloid cells with human cytomegalovirus induces a number of changes in gene expression.", "Mice are incapable of producing neutralizing antibodies in reponse to the Chikungunya virus (CHIKV) produced in mosquitos."], "hard_negative": "Rising temperatures caused by global warming increases risk of dengue fever transmission."}
{"query_id": "1053", "query_text": "Rising temperatures caused by global warming lowers the risk of dengue fever transmission.", "negative": "Chenodeoxycholic acid treatment decreases brown adipose tissue activity.", "negatives": ["Chenodeoxycholic acid treatment decreases brown adipose tissue activity.", "Stroke patients with prior use of direct oral anticoagulants have a higher risk of in-hospital mortality than stroke patients with prior use of warfarin.", "Peroxynitrite is required for induction of T cell tolerance.", "Removal of H3K9me3 by ectopic expression of other H3K9 demethylases decreases reprogramming efficiency in SCNT experiments.", "Nonhuman primates are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.", "Adult tissue-resident macrophages stem from the embryonal yolk sac and fetal liver.", "Increased microtubule acetylation worsens interference of axonal transport caused by LRRK2 Roc-COR domain mutations.", "Bacterial meningitis can be diagnosed on the basis of positive cerebrospinal fluid (CSF) cultures.", "HNF4A mutations are associated with macrosomia in infancy.", "TRAP+ osteoclasts regulate mature osteoblast maintenance."], "hard_negatives": ["Rising temperatures caused by global warming increases risk of dengue fever transmission.", "Rising temperatures caused by global warming lowers the risk of dengue fever transmission.", "Urbanization is an important risk factor related to the transmission of dengue fever.", "Malaria has a high vectorial capacity.", "There was an estimated 30 million cases of pneumonia in young children worldwide in 2010.", "Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission.", "The World Health Organization's (WHO) data collection process is biased downward by unequal selection of larger outbreaks.", "Eliminating the last sporadic cases of malaria requires considerable funding.", "Eilat virus (EILV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in nonhuman primates.", "Mice are incapable of producing neutralizing antibodies in reponse to the Chikungunya virus (CHIKV) produced in mosquitos."], "hard_negative": "Rising temperatures caused by global warming increases risk of dengue fever transmission."}
{"query_id": "1054", "query_text": "Risk of cardiovascular events can be cut by a third by using antihypertensive drug therapy among hemodialysis patients.", "negative": "Environmentally-induced senescence is mimicked in disease modeling by adding specific molecules to the culture system.", "negatives": ["Environmentally-induced senescence is mimicked in disease modeling by adding specific molecules to the culture system.", "Metastatic colorectal cancer treated with a single agent fluoropyrimidines resulted in similar efficacy and better quality of life when compared with oxaliplatin-based chemotherapy in elderly patients.", "H4 G94P proteins induce chromatin assembly, which increases free histones.", "The DESMOND program demonstrates no significant impact on lifestyles outcomes.", "Osteocytes have an essential role in G-CSF induced HSPC mobilization.", "Oat tolerant coeliac patients may have oat specific inflammatory cells in their small bowel mucosa.", "Helicobacter pylori-induced aberrant NF-kB-dependent expression of activation-induced cytidine deaminase contributes to the mutagenesis of host DNA.", "RUNX is not expressed in skin tissue.", "0-dimensional biomaterials lack inductive properties.", "10% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months."], "hard_negatives": ["Risk of cardiovascular events can be cut by a third by using antihypertensive drug therapy among hemodialysis patients.", "In young and middle-aged adults, current or remote uses of ADHD medications increase the risk of serious cardiovascular events.", "Diabetic patients with acute coronary syndrome experience decreased short-term and long-term risk for bleeding events.", "Systemic lupus erythematosus is a risk factor for cardiovascular disease.", "CRP is positively correlated with postoperative mortality following Coronary Artery Bypass Graft (CABG) surgery.", "Sudden death can occur in patients with orthostatic hypertension without cardiac conduction abnormalities.", "Insulin decreases risk of severe kidney failure.", "Including pharmacists in rounding teams does not alter the incidence of adverse drug events (ADEs).", "Side effects associated with antidepressants increases risk of stroke.", "Side effects associated with antidepressants lower risk of myocardial infarction."], "hard_negative": "Risk of cardiovascular events can be cut by a third by using antihypertensive drug therapy among hemodialysis patients."}
{"query_id": "1055", "query_text": "Risk-adjusted mortality rates are similar in teaching and non-teaching hospitals.", "negative": "Activator-inhibitor pairs are provided ventrally by Xrl-sizzled.", "negatives": ["Activator-inhibitor pairs are provided ventrally by Xrl-sizzled.", "The G34R/V mutation creates a hypomethylated phenotype at the H3K36 histone.", "MafA phosphorylation decreases its ubiquitination.", "Incidence of sepsis has fallen substantially from 2009 to 2014.", "Natriuretic peptides protect against diabetes.", "5'-nucleotidase metabolizes 6MP.", "Weighed food records (WFR) result in poor completion since they're costly to run and impose high participant burden.", "Genetic deletion of JAM-A increases gut permeability.", "Obesity raises life quality.", "Reduction of purity of cytoplasmic membranes isolated from overexpressors is indicated by stronger spots for OmpF in 2D BN-PAGE gels."], "hard_negatives": ["Risk-adjusted mortality rates are similar in teaching and non-teaching hospitals.", "Sepsis related mortality has risen from 2009 to 2014.", "Cost effectiveness evaluations based on cRCT data accurately reflect prices for patients in actual clinical practice.", "Sepsis related mortality has remained stable between 2009-2014.", "Students who perform poorly in the early years of medical school are less likely to commit professional misconduct later in their careers.", "The mean suicide rate in women is lower after miscarriage than live birth.", "The mean suicide rate in women is higher after miscarriage than live birth.", "Assessing treatment adherence is more beneficial to clinical practice than measuring routine outcomes.", "Tuberculosis incidence occurs at higher rates in more sparsely populated areas in the UK.", "Students who perform poorly in the early years of medical school are at increased risk for professional misconduct later in their careers."], "hard_negative": "Risk-adjusted mortality rates are similar in teaching and non-teaching hospitals."}
{"query_id": "1056", "query_text": "Rotator cuff exercises are more effective than general exercise therapy in reducing pain and improving function of the shoulder.", "negative": "Notch signaling occurs between tumor cells and stromal cells.", "negatives": ["Notch signaling occurs between tumor cells and stromal cells.", "H4 G94P proteins induce chromatin assembly, which increases free histones.", "Cancers that initially benefit from epidermal growth factor receptor targeted therapies later become refractory through several mechanisms.", "The gene daf-16, which encodes forkhead Box O (FOXO), is required for all phenotypes associated with reduced insulin/insulin-like growth factor (Igf) signaling.", "The ability of activator E2Fs in preventing cell death is limited to terminally differentiated cells.", "Mice lacking Sirt1 in Sf1-expressing neurons are immune to diet-induced obesity and insulin resistance.", "Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 encourage West Nile virus replication in cortical neurons.", "Pharmacist attendance at ward rounds reduces adverse events in wards.", "Formation of N-terminal pyroglutamate by glutamine cyclase (GC) competes with NTAQ1 for Nt-Gln substrates.", "The artifactual C-terminal helix swapping in the StART domain is observed in the Ups1-Mdm35 heterodimer of the StARkin superfamily."], "hard_negatives": ["Rotator cuff exercises are more effective than general exercise therapy in reducing pain and improving function of the shoulder.", "General exercise therapy is more effective than rotator cuff exercises in reducing pain and improving function of the shoulder.", "Scapular stabilizer exercises are more effective than general exercise therapy in reducing pain and improving function of the shoulder.", "General exercise therapy is more effective than scapular stabilizer exercises in reducing pain and improving function of the shoulder.", "Surgical treatment is not superior to non-surgical in treating adults with displaced fractures of the proximal humerus.", "Roughly 55% of women with chronic pelvic pain have no underlying pathology.", "There is a positive correlation between hip fractures and statin use.", "Osteoparthritis (OA) is characterized by degeneration of articular cartilage, joint edge, and subchondral bone hyperplasia.", "Bariatric surgery leads to negative outcomes in mental health.", "Propriospinal interneurons that play a role in the plastic reorganization of spinal circuits are integral for recovery from spinal cord injury."], "hard_negative": "Rotator cuff exercises are more effective than general exercise therapy in reducing pain and improving function of the shoulder."}
{"query_id": "1058", "query_text": "Roughly 55% of women with chronic pelvic pain have no underlying pathology.", "negative": "Egr3 regulates the homeostasis of B and T cells.", "negatives": ["Egr3 regulates the homeostasis of B and T cells.", "FACT and other histone chaperone(s) compensate for Histone 2A (H2A)-histone 2B (H2B) dimer eviction during the histone exchange process.", "Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission.", "\u03b21/Ketel is able to bind microtubules.", "Amitriptyline is an effective treatment for chronic tension-type headaches.", "Androgenetic haploid mouse embryonic stem cells (ESCs) can be derived and genetically manipulated in vitro.", "Low expression of miR7a does not repress target genes or exert a biological function in testis.", "The one-child policy has created a hospitable environment for female infants.", "The C-type lectin receptor (CLEC-2) rearranges the actin cytoskeleton in dendritic cells to promote efficient motility along stromal surfaces.", "The US health care system can save up to $5 billion if 7% of patients waiting for kidney transplants participate in the optimized national kidney paired donation program."], "hard_negatives": ["Roughly 55% of women with chronic pelvic pain have no underlying pathology.", "Surgical treatment is not superior to non-surgical in treating adults with displaced fractures of the proximal humerus.", "Osteoparthritis (OA) is characterized by degeneration of articular cartilage, joint edge, and subchondral bone hyperplasia.", "General exercise therapy is more effective than rotator cuff exercises in reducing pain and improving function of the shoulder.", "Rotator cuff exercises are more effective than general exercise therapy in reducing pain and improving function of the shoulder.", "General exercise therapy is more effective than scapular stabilizer exercises in reducing pain and improving function of the shoulder.", "Scapular stabilizer exercises are more effective than general exercise therapy in reducing pain and improving function of the shoulder.", "Bariatric surgery leads to negative outcomes in mental health.", "The peak incidence of fractures occurs in toddlers.", "Bacterial meningitis can be diagnosed on the basis of positive cerebrospinal fluid (CSF) cultures."], "hard_negative": "Roughly 55% of women with chronic pelvic pain have no underlying pathology."}
{"query_id": "1065", "query_text": "Satellite cell dysfunction is a key factor in sarcopenia development.", "negative": "Nonsteroidal antinflammatory drugs are ineffective as cancer treatments.", "negatives": ["Nonsteroidal antinflammatory drugs are ineffective as cancer treatments.", "Moderate consumption of candy and chocolate reduces the risk of cardiovascular disease (CVD).", "Transcription rates in S. cerevisiae range between 7 and 12 kb/min.", "53% of perinatal mortality is due to low birth weight.", "Cellular clocks are not predictive of mitosis timing in NIH 3T3 cells.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have increased risk for Alzheimer's disease.", "Pediatric SCD patients with vaso-occlusive crisis show increased morphine use after breathing 80 ppm iNO for 4 hours.", "The RANK-RANK-Ligand (RANKL) pathway is involved in the development of Aire-expressing medullary thymic epithelial cells (mTECs).", "Ultrasound guidance significantly reduces the number of traumatic procedures when attempting needle insertion.", "Pioglitazone use is not associated with an increased risk of prostate cancer."], "hard_negatives": ["Satellite cell dysfunction is a key factor in sarcopenia development.", "The cytokine receptor which regulates chemotaxis and formation of lymph nodes is involved in production of myeloperoxidase in the left atrium.", "Differentiation of progenitor cells to myeloid cells is skewed upon activation of insulin signaling.", "Osteoparthritis (OA) is characterized by degeneration of articular cartilage, joint edge, and subchondral bone hyperplasia.", "Differentiation of progenitor cells to myeloid cells is skewed when insulin signaling is suppressed.", "Propriospinal interneurons that play a role in the plastic reorganization of spinal circuits are integral for recovery from spinal cord injury.", "The proliferative capacity of neural progenitors differs across species.", "The proliferative capacity of progenitors is regulated cell-autonomously.", "Cancer cells can stimulate the accumulation of intra-tumoural myeloid-derived suppressor cells by promoting granulocyte colony stimulating factor production.", "Klf4 is important for proper myeloid cell differentiation."], "hard_negative": "Satellite cell dysfunction is a key factor in sarcopenia development."}
{"query_id": "1067", "query_text": "ScPif1p has higher binding ability to G-rich ssDNA than to non-G-rich ssDNA.", "negative": "5'-nucleotidase metabolizes 6MP.", "negatives": ["5'-nucleotidase metabolizes 6MP.", "There is a positive correlation between hip fractures and statin use.", "Tonic signaling from the scFv induces constitutive stimulation.", "At least 85% of patients exposed to radiation have activated markers of myofibroblasts.", "Primary cervical cytology screening with HPV detection has higher longitudinal sensitivity to detect severe cervical intraepithelial neoplasia than conventional cytology.", "Participants who quit smoking reduce lung cancer risk by approximately 50%.", "PD-1 triggering on monocytes enhances IL-10 production by monocytes.", "Active caspase-11 participate in regulating phagosome-lysosome fusion.", "H4 G94P proteins induce chromatin assembly, which increases free histones.", "Increased mobility of retrotransposons is assosciated with mutation and higher tumorigenesis rates."], "hard_negatives": ["ScPif1p has higher binding ability to G-rich ssDNA than to non-G-rich ssDNA.", "ScPif1p has reduced binding ability to G-rich ssDNA compared to non-G-rich ssDNA.", "Mutations in G-Beta protein GNB1 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.", "The deamination of cytidine to uridine on the minus strand of viral DNA can inactivate the viral genome by inducing G-to-A mutations.", "Deltex has no known interactions with eIF3f.", "Bcp1 is a chaperone for Rpl23.", "The G34R/V mutation does not create a hypomethylated phenotype at the H3K36 histone.", "The PPR MDA5 has twenty N-terminal CARD domains.", "Pyridostatin stabilizes the G - quadruplex in the telomeric region.", "The G34R/V mutation creates a hypomethylated phenotype at the H3K36 histone."], "hard_negative": "ScPif1p has higher binding ability to G-rich ssDNA than to non-G-rich ssDNA."}
{"query_id": "1068", "query_text": "ScPif1p has reduced binding ability to G-rich ssDNA compared to non-G-rich ssDNA.", "negative": "Migraine with aura is associated with ischemic stroke.", "negatives": ["Migraine with aura is associated with ischemic stroke.", "Incidence of 10/66 dementia is higher than the incidence of DSM-IV dementia.", "Amitriptyline is an effective treatment for chronic tension-type headaches.", "HOXB4 facilitates HSC expansion when co-cultured with HSCs.", "Consumption of whole fruits increases the risk of type 2 diabetes.", "Lice attenuated SIV vaccines induce a stronger antigen-specific T cell response in lymph node cells.", "Anthrax spores remain deadly until affected areas are decontaminated.", "A deficiency of vitamin B6 decreases blood levels of homocysteine.", "Binding of p53 to enhancer regions (p53BERs) regulates the activity of p53 transcription and cell cycle arrest through the production of p53-dependent eRNAs.", "Notch signaling occurs between tumor cells and stromal cells."], "hard_negatives": ["ScPif1p has reduced binding ability to G-rich ssDNA compared to non-G-rich ssDNA.", "ScPif1p has higher binding ability to G-rich ssDNA than to non-G-rich ssDNA.", "Mutations in G-Beta protein GNB1 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.", "The deamination of cytidine to uridine on the minus strand of viral DNA can inactivate the viral genome by inducing G-to-A mutations.", "Deltex has no known interactions with eIF3f.", "The G34R/V mutation does not create a hypomethylated phenotype at the H3K36 histone.", "Bcp1 is a chaperone for Rpl23.", "The G34R/V mutation creates a hypomethylated phenotype at the H3K36 histone.", "Pyridostatin stabilizes the G - quadruplex in the telomeric region.", "The PPR MDA5 has twenty N-terminal CARD domains."], "hard_negative": "ScPif1p has reduced binding ability to G-rich ssDNA compared to non-G-rich ssDNA."}
{"query_id": "1069", "query_text": "Scapular stabilizer exercises are more effective than general exercise therapy in reducing pain and improving function of the shoulder.", "negative": "Walking in traffic areas in London did not improve lung function in elderly adults.", "negatives": ["Walking in traffic areas in London did not improve lung function in elderly adults.", "76-85% of people with severe mental disorder receive no treatment in low and middle income countries.", "Immune responses in immune cells are geographically segregated.", "Nonhypertensive people who are 55 years old have a 90% chance of developing hypertension during their lifetime.", "p16INK4A degradation is  linked to an abnormal wound response caused by the microinvasive step of advanced Oral Potentially Malignant Lesions (OPMLs).", "Upregulation of PD1 causes the downmodulation of Satb1.", "Induced hepatic stem cells possess the potential to differentiate into cholangiocytic cells.", "Propriospinal interneurons that play a role in the plastic reorganization of spinal circuits are integral for recovery from spinal cord injury.", "The morphology change from large white adipocytes to small brown adipocytes is a sign of decreased energy expenditure potential in white adipose tissue.", "Less than 10% of patients exposed to radiation have activated markers of mesenchymal stem cells."], "hard_negatives": ["Scapular stabilizer exercises are more effective than general exercise therapy in reducing pain and improving function of the shoulder.", "General exercise therapy is more effective than scapular stabilizer exercises in reducing pain and improving function of the shoulder.", "Rotator cuff exercises are more effective than general exercise therapy in reducing pain and improving function of the shoulder.", "General exercise therapy is more effective than rotator cuff exercises in reducing pain and improving function of the shoulder.", "Surgical treatment is not superior to non-surgical in treating adults with displaced fractures of the proximal humerus.", "There is a positive correlation between hip fractures and statin use.", "Amitriptyline is an effective treatment for chronic tension-type headaches.", "Roughly 55% of women with chronic pelvic pain have no underlying pathology.", "Bariatric surgery leads to positive outcomes in mental health.", "Antidepressants reduce the severity of migraines."], "hard_negative": "Scapular stabilizer exercises are more effective than general exercise therapy in reducing pain and improving function of the shoulder."}
{"query_id": "1070", "query_text": "Self-advocacy training is effective at decreasing homelessness.", "negative": "A mutation in HNF4A leads to an increased risk of diabetes by the age of 14 years.", "negatives": ["A mutation in HNF4A leads to an increased risk of diabetes by the age of 14 years.", "Helminths interfere with immune system control of coinfections by microbial pathogens 16.", "At least 85% of patients exposed to radiation have activated markers of myofibroblasts.", "Cognitive behavioral therapy is an ineffective treatment for insomnia", "Weighed food records (WFR) result in poor completion since they're costly to run and impose high participant burden.", "Ly49Q directs the organization of neutrophil polarization by regulating membrane raft functions.", "Guanine nucleotide dissociation inhibitor (Rho-GDI) interacts with the p75 NTR death domain", "Origin gross domestic product(GDP) is positively related to dengue virus (DENV-1) diffusion in air traffic shipments.", "Activator-inhibitor pairs are provided ventrally by Xrl-sizzled.", "A country's Vaccine Alliance (GAVI) eligibility is not indictivate of accelerated adoption of the Hub vaccine."], "hard_negatives": ["Self-advocacy training is effective at decreasing homelessness.", "Input from  mental and physical health care professionals is not effective at decreasing homelessness.", "Integrated care is successful at tackling multiple comorbidities.", "Integrated care is ineffective at tackling multiple comorbidities.", "Having a main partner improves HIV outcomes.", "Assessing treatment adherence is more beneficial to clinical practice than measuring routine outcomes.", "Cognitive behavioral therapy is an ineffective treatment for insomnia", "Measuring routine outcomes is more beneficial to clinical practice than assessing treatment adherence.", "Integrating classroom-based collaborative learning with Web-based collaborative learning offers the best class performance.", "Bariatric surgery leads to positive outcomes in mental health."], "hard_negative": "Self-advocacy training is effective at decreasing homelessness."}
{"query_id": "1072", "query_text": "Sepsis related mortality has remained stable between 2009-2014.", "negative": "Major vault protein regulates sorting of tumor suppressive miR-193a into EVs.", "negatives": ["Major vault protein regulates sorting of tumor suppressive miR-193a into EVs.", "The US health care system can save up to $5 billion if 7% of patients waiting for kidney transplants participate in the optimized national kidney paired donation program.", "Cost effectiveness evaluations based on cRCT data lack external validity.", "Deltex has no known interactions with eIF3f.", "Chenodeoxycholic acid treatment decreases brown adipose tissue activity.", "Including pharmacists in rounding teams reduces the incidence of adverse drug events (ADEs).", "Pediatric SCD patients with vaso-occlusive crisis show increased morphine use after breathing 80 ppm iNO for 4 hours.", "In melanoma, anti-CTLA-4 treatment reinvigorates exhausted PD-1+Eomes+CD8 T cells.", "The PRDM1 gene, when combined with the PRDM14 gene, plays an important role during primordial germ cell specification.", "Increase of p62 in prostate tumor stroma results in defective autophagy."], "hard_negatives": ["Sepsis related mortality has risen from 2009 to 2014.", "Sepsis related mortality has remained stable between 2009-2014.", "Incidence of sepsis has fallen substantially from 2009 to 2014.", "10% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.", "90% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.", "The mean suicide rate in women is higher after miscarriage than live birth.", "The mean suicide rate in women is lower after miscarriage than live birth.", "53% of perinatal mortality is due to low birth weight.", "Risk-adjusted mortality rates are similar in teaching and non-teaching hospitals.", "Tuberculosis incidence occurs at higher rates in more sparsely populated areas in the UK."], "hard_negative": "Sepsis related mortality has risen from 2009 to 2014."}
{"query_id": "1073", "query_text": "Sepsis related mortality has risen from 2009 to 2014.", "negative": "Helminths interfere with immune system control of coinfections by microbial pathogens 16.", "negatives": ["Helminths interfere with immune system control of coinfections by microbial pathogens 16.", "CCL19 is a ligand for CCR7.", "The DESMOND program caused substantial weight loss in most participants.", "Low expression of miR7a does not repress target genes or exert a biological function in testis.", "The proliferative capacity of neural progenitors differs across species.", "CHOP is a general endoplasmic reticulum stress marker.", "The DESMOND program demonstrates no significant impact on biochemical outcomes.", "N348I mutations reduce resistance to nevirapine.", "A deficiency of vitamin B6 decreases blood levels of homocysteine.", "Diabetes remission occurs less in people treated with conventional therapy than in people treated with laparoscopic adjustable gastric banding surgery."], "hard_negatives": ["Sepsis related mortality has risen from 2009 to 2014.", "Incidence of sepsis has fallen substantially from 2009 to 2014.", "Sepsis related mortality has remained stable between 2009-2014.", "90% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.", "10% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.", "The mean suicide rate in women is higher after miscarriage than live birth.", "The mean suicide rate in women is lower after miscarriage than live birth.", "There was an estimated 30 million cases of pneumonia in young children worldwide in 2010.", "53% of perinatal mortality is due to low birth weight.", "Risk-adjusted mortality rates are similar in teaching and non-teaching hospitals."], "hard_negative": "Sepsis related mortality has risen from 2009 to 2014."}
{"query_id": "1074", "query_text": "Sequence conservation in gene regulatory regions between species is a high-accuracy predictor of conserved functionality.", "negative": "ITAM phosphorylation allows for the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).", "negatives": ["ITAM phosphorylation allows for the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).", "Tonic signaling from the scFv is amplified by MyD88/CD40.", "Stroke patients with prior use of direct oral anticoagulants have a higher risk of in-hospital mortality than stroke patients with prior use of warfarin.", "MEK inhibitors are effective treatments in RAS-driven mouse models of cancer.", "The appearance of brown-like or beige cells primarily occurs in visceral fat, not subcutaneous fat.", "Addition of BMP4, activin A, CHIR99021, and SU504 to reprogramming fibroblasts generates, expands and maintains cardiovascular progenitor cells (CPCs)", "Post-transcriptional handling of mitochondrial transcripts occurs in mitochondrial RNA granules.", "The first MBT repeat of the four malignant brain tumor (4MBT) domain of Drosophila's Sfmbt and of the orthologous mammalian L3MBTL2 is required for the interaction with the spacer region of Drosophila's Pleiohomeotic (Pho) or its human ortholog YY1.", "Inhibiting glucose-6-phospate dehydrogenase improves lipogenesis by deactivating LKB1-AMPK signaling.", "4-PBA treatment raises endoplasmic reticulum stress in response to general endoplasmic reticulum stress markers."], "hard_negatives": ["Sequence conservation in gene regulatory regions between species is a high-accuracy predictor of conserved functionality.", "Sequence conservation in gene regulatory regions between species is a poor predictor of conserved functionality.", "Low nucleosome occupancy correlates with high methylation levels across species.", "Long - range chromatin interactions regulate transcription.", "Genes involved in pre-mRNA splicing have a significant impact on genome stability.", "r-protein chaperones are found in complexes with their r-protein binding partners.", "Distant CREs are less conserved among species.", "The repeat-variable diresidue (RVD) in the loop of Transcription-Activator Like (TAL) effectors specifies the nucleotides-amino acid contact at the target promoter element.", "mcm 5 s 2 U is required for proper decoding of NNR codons in eukaryotes.", "Pseudoknots are not evolutionarily conserved in most eukaryotes."], "hard_negative": "Sequence conservation in gene regulatory regions between species is a high-accuracy predictor of conserved functionality."}
{"query_id": "1075", "query_text": "Sequence conservation in gene regulatory regions between species is a poor predictor of conserved functionality.", "negative": "Noninvasive positive pressure ventilation is not predictive of acute respiratory failure after solid organ transplantation.", "negatives": ["Noninvasive positive pressure ventilation is not predictive of acute respiratory failure after solid organ transplantation.", "DRD1 proteins enable Pol V transcription in vivo.", "Traditional reviews are biased in their interpretations.", "The density of cytokine receptor bearing cells has no effect on the distance over which cytokines act.", "The latent infection of myeloid cells with human cytomegalovirus induces a number of changes in gene expression.", "Omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegetarians.", "Urbanization is an important risk factor related to the transmission of dengue fever.", "The number of unfertilized oocytes in mated hermaphrodites increases with age.", "Pyridostatin stabilizes the G - quadruplex in the telomeric region.", "Natriuretic peptides increase susceptibility to diabetes."], "hard_negatives": ["Sequence conservation in gene regulatory regions between species is a poor predictor of conserved functionality.", "Sequence conservation in gene regulatory regions between species is a high-accuracy predictor of conserved functionality.", "Low nucleosome occupancy correlates with high methylation levels across species.", "Long - range chromatin interactions regulate transcription.", "Genes involved in pre-mRNA splicing have a significant impact on genome stability.", "r-protein chaperones are found in complexes with their r-protein binding partners.", "Distant CREs are less conserved among species.", "Pseudoknots are not evolutionarily conserved in most eukaryotes.", "mcm 5 s 2 U is required for proper decoding of NNR codons in eukaryotes.", "The repeat-variable diresidue (RVD) in the loop of Transcription-Activator Like (TAL) effectors specifies the nucleotides-amino acid contact at the target promoter element."], "hard_negative": "Sequence conservation in gene regulatory regions between species is a poor predictor of conserved functionality."}
{"query_id": "1081", "query_text": "Side effects associated with antidepressants do not represent a mortality risk to postmenopausal women.", "negative": "Deletion of ATM and Rad3 related protein is not predictive of acute tissue loss.", "negatives": ["Deletion of ATM and Rad3 related protein is not predictive of acute tissue loss.", "Individuals with Alzheimers who participate in six months of physical activity improve cognitive function for up to 18 months.", "Mice without IFN-\u03b3 or its receptor are highly susceptible to EAM induced with \u03b1-MyHC/CFA.", "Bacterial meningitis can be diagnosed on the basis of positive cerebrospinal fluid (CSF) cultures.", "Hematopoietic Stem Cell purification reaches purity rates above 90%.", "Gpr124 increases BBB breakdown in mouse models of ischemic stroke.", "Omnivores produce less trimethylamine N-oxide from dietary I-carnitine than vegans.", "Immune responses in immune cells are geographically segregated.", "siRNA knockdown of A20 accelerates tumor progression in an in vivo murine xenograft model.", "Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission."], "hard_negatives": ["Side effects associated with antidepressants do not represent a mortality risk to postmenopausal women.", "Side effects associated with antidepressants increases risk of stroke.", "Sildenafil worsens erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.", "Side effects associated with antidepressants lower risk of myocardial infarction.", "Antidepressants reduce the severity of migraines.", "Antidepressants increase the severity of migraines.", "A breast cancer patient's capacity to metabolize tamoxifen influences treatment outcome.", "The most prevalent adverse events to Semaglutide are cardiovascular.", "In young and middle-aged adults, current or remote uses of ADHD medications increase the risk of serious cardiovascular events.", "Pioglitazone use is significantly associated with an increased risk of prostate cancer."], "hard_negative": "Side effects associated with antidepressants do not represent a mortality risk to postmenopausal women."}
{"query_id": "1084", "query_text": "Side effects associated with antidepressants increases risk of stroke.", "negative": "Mitochondria play a major role in apoptosis.", "negatives": ["Mitochondria play a major role in apoptosis.", "Asymptomatic visual impairment screening in elderly populations leads to improved vision.", "Taxation of sugar-sweetened beverages reduced the incidence rate of type II diabetes in India.", "Increased microtubule acetylation repairs interference of axonal transport caused by LRRK2 Roc-COR domain mutations.", "LRBA prevents CTLA - 4 recycling.", "Pro-inflammatory cytokines are up regulated during tumor development.", "Osteoparthritis (OA) is characterized by degeneration of articular cartilage, joint edge, and subchondral bone hyperplasia.", "TNFAIP3 is a tumor enhancer in glioblastoma.", "Cost effectiveness evaluations based on cRCT data lack external validity.", "The DEXI promoter region is bound by multiple transcription factors in a murine haematopoietic progenitor cell line."], "hard_negatives": ["Side effects associated with antidepressants increases risk of stroke.", "Side effects associated with antidepressants lower risk of myocardial infarction.", "Side effects associated with antidepressants do not represent a mortality risk to postmenopausal women.", "Antidepressants increase the severity of migraines.", "Antidepressants reduce the severity of migraines.", "Sildenafil worsens erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.", "In young and middle-aged adults, current or remote uses of ADHD medications increase the risk of serious cardiovascular events.", "The most prevalent adverse events to Semaglutide are cardiovascular.", "Stroke patients with prior use of direct oral anticoagulants have a higher risk of in-hospital mortality than stroke patients with prior use of warfarin.", "Dexamethasone increases risk of postoperative bleeding."], "hard_negative": "Side effects associated with antidepressants increases risk of stroke."}
{"query_id": "1085", "query_text": "Side effects associated with antidepressants lower risk of myocardial infarction.", "negative": "There was an estimated 30 million cases of pneumonia in young children worldwide in 2010.", "negatives": ["There was an estimated 30 million cases of pneumonia in young children worldwide in 2010.", "61% of colorectal cancer patients are diagnosed with regional or distant metastases.", "Microglia are an innate immune cell type of the peripheral nervous system.", "Headaches are correlated with cognitive impairment.", "Human embryonic stem cells give rise to cell types from the outer embryonic germ layer, but not the other two layers.", "90% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.", "RUNX1 is downregulated or mutated in TLX1 T-ALL.", "Weighed food records (WFR) result in poor completion since they're costly to run and impose high participant burden.", "H4 G94P proteins suppress degradation of free histones via Rad53-dependent mechanisms.", "aPKCz causes tumour suppression by affecting glutamine metabolism."], "hard_negatives": ["Side effects associated with antidepressants lower risk of myocardial infarction.", "Side effects associated with antidepressants increases risk of stroke.", "Side effects associated with antidepressants do not represent a mortality risk to postmenopausal women.", "Antidepressants increase the severity of migraines.", "Antidepressants reduce the severity of migraines.", "In young and middle-aged adults, current or remote uses of ADHD medications increase the risk of serious cardiovascular events.", "The most prevalent adverse events to Semaglutide are gastrointestinal.", "The most prevalent adverse events to Semaglutide are cardiovascular.", "Sildenafil worsens erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.", "Pioglitazone use is significantly associated with an increased risk of pancreatic cancer."], "hard_negative": "Side effects associated with antidepressants lower risk of myocardial infarction."}
{"query_id": "1087", "query_text": "Sildenafil worsens erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.", "negative": "Charcoal is an effective treatment for acute paraquat poisoning.", "negatives": ["Charcoal is an effective treatment for acute paraquat poisoning.", "COPI coatmer is involved in viral replication.", "Low nucleosome occupancy correlates with high methylation levels across species.", "AZT given with ribavirin increases anemia.", "De novo assembly of sequence data has fewer specific contigs than unassembled sequence data.", "Reduction of purity of cytoplasmic membranes isolated from overexpressors is indicated by stronger spots for OmpA in 2D BN-PAGE gels.", "Low expression of miR7a does not repress target genes or exert a biological function in ovaries.", "PD-1 triggering on monocytes enhances IL-10 production by monocytes.", "There is no association between HNF4A mutations and diabetes risks.", "Myelin sheaths play a role in action potential propagation."], "hard_negatives": ["Sildenafil worsens erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.", "Side effects associated with antidepressants do not represent a mortality risk to postmenopausal women.", "Side effects associated with antidepressants increases risk of stroke.", "Pioglitazone use is significantly associated with an increased risk of prostate cancer.", "Pioglitazone use is not associated with an increased risk of prostate cancer.", "Antidepressants reduce the severity of migraines.", "Antidepressants increase the severity of migraines.", "A breast cancer patient's capacity to metabolize tamoxifen influences treatment outcome.", "The most prevalent adverse events to Semaglutide are cardiovascular.", "Amitriptyline is an effective treatment for chronic tension-type headaches."], "hard_negative": "Sildenafil worsens erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants."}
{"query_id": "1090", "query_text": "Smc5/6 engagment halts the activation of SUMO E3 ligase Mms21 by ATP-dependent remolding.", "negative": "Energy balance requires hypothalamic glutamate neurotransmission.", "negatives": ["Energy balance requires hypothalamic glutamate neurotransmission.", "Sequence conservation in gene regulatory regions between species is a high-accuracy predictor of conserved functionality.", "The tip of the inner tube of the toxic type VI secretion system (T6SS) antibacterial effector in Escherichia coli (E. coli) is decorated with VgrG and PAAR proteins.", "There is a positive correlation between hip fractures and statin use.", "MafA ubiquitination decreases the recruitment of coavtivator P/CAF by MafA.", "Blocking the interaction between TDP-43 and respiratory complex I proteins ND3 and ND6 prevents TDP-43-induced neuronal loss.", "Major vault protein regulates sorting of tumor suppressive miR-193a into EVs.", "The proliferative capacity of neural progenitors differs across species.", "Formation of N-terminal pyroglutamate by glutamine cyclase (GC) competes with NTAQ1 for Nt-Gln substrates.", "PrimPol degrades short DNA replication intermediates on the leading strand during DNA replication."], "hard_negatives": ["Smc5/6 engagment halts the activation of SUMO E3 ligase Mms21 by ATP-dependent remolding.", "JMJD6 catalyzes the hydroxylation of C-terminal lysine and supresses transcriptional activity.", "Binding of p53 to enhancer regions (p53BERs) regulates the activity of p53 transcription and cell cycle arrest through the production of p53-dependent eRNAs.", "Ribosome-inactivating protein-2 (RIP-2) interacts with the p75 NTR death domain", "JMJD6 slows the hydroxylation of C-terminal lysine", "The microtubule-dependent delivery and secretion of matrix metalloproteases (MMPs) is partially responsible for the disassembly of adhesion sites.", "Intramembrane cleavage by signal peptide peptidase aids in the degradation of proteins with a complex membrane orientation.", "p16INK4A degradation is encoded by CDKN2A.", "Activation of PPM1D enhances p53 function.", "H4 G94P proteins induce degradation of free histones via Rad53-dependent mechanisms."], "hard_negative": "Smc5/6 engagment halts the activation of SUMO E3 ligase Mms21 by ATP-dependent remolding."}
{"query_id": "1091", "query_text": "Sn is present on mature DCs during inflammation in vivo.", "negative": "Cholesterol loading induces KLF4 expression in VSMCs, resulting in the expression of pro-inflammatory cytokines.", "negatives": ["Cholesterol loading induces KLF4 expression in VSMCs, resulting in the expression of pro-inflammatory cytokines.", "NR5A2 is important in reverse cholesterol transport in humans.", "Monoclonal antibody targeting of N-cadherin inhibits growth.", "The most prevalent adverse events to Semaglutide are cardiovascular.", "Sympathetic nerve activity is elevated throughout normal pregnancy.", "The deregulated and prolonged activation of monocytes improves inflammatory disease outcomes.", "TNFAIP3 is a glioblastoma tumor suppressor.", "Increase of p62 in prostate tumor stroma results in defective autophagy.", "Expression of oncolytic virus antigens as peptides permits additional protection against relapse.", "Foxp3 represses the expression of transcriptional regulators implicated in memory T cell development."], "hard_negatives": ["Sn is present on mature DCs during inflammation in vivo.", "R2D2 stops miRNA production by increasing the selectivity of Dcr2 for long dsRNA.", "CCL19 is predominantly present within dLNs.", "Peroxynitrite is required for induction of T cell tolerance.", "N348I mutations cause resistance to nevirapine.", "N348I mutations reduce resistance to nevirapine.", "NAC destabilizes NO to increase the effect of contrast agents on renal functions.", "Cholesterol loading induces KLF4 expression in VSMCs, resulting in the expression of pro-inflammatory cytokines.", "KLF4 is necessary for VSMCs to gain genetic characteristics of other cell types within atherosclerotic lesions.", "The HSV-2 infection is typically asymptomatic."], "hard_negative": "Sn is present on mature DCs during inflammation in vivo."}
{"query_id": "1096", "query_text": "Specialized functional cell types can be derived from human pluripotent stem cells.", "negative": "The myocardial cell lineage originally develops from cardiac progenitors of exclusively endodermal origin.", "negatives": ["The myocardial cell lineage originally develops from cardiac progenitors of exclusively endodermal origin.", "Long chain polyunsaturated fatty acids supplementation reduces wheezing and asthma.", "Lack of FGF21 in mice leads to reduced lifespan.", "Obesity decreases life quality.", "Increased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm.", "Treatment with a protein named FN impairs regenerative abilities of aged muscles.", "ERAP1 SNPs are epistatic to HLA alleles for ankylosing spondylitis.", "Exhaustion of B cells contributes to poor Ab response in HIV-infected individuals.", "Pro-inflammatory cytokines are up regulated during tumor development.", "A mutation in HNF4A leads to an increased risk of diabetes by the age of 14 years."], "hard_negatives": ["Specialized functional cell types can be derived from human pluripotent stem cells.", "Human embryonic stem cells give rise to cell types from all three embryonic germ layers.", "Human embryonic stem cells have the capacity to give rise to differentiated progeny representative of all three embryonic germ layers.", "Human embryonic stem cells give rise to cell types from the outer embryonic germ layer, but not the other two layers.", "Androgenetic haploid mouse embryonic stem cells (ESCs) can be derived and genetically manipulated in vitro.", "Transplanted human glial progenitor cells can mature in their host animal.", "Adult tissue-resident macrophages stem from the embryonal yolk sac and fetal liver.", "Adult tissue-resident macrophages stem from the embryonal yolk sac and fetal liver.", "Bone marrow cells don't contribute to adult macrophage compartments.", "The proliferative capacity of progenitors is regulated cell-autonomously."], "hard_negative": "Specialized functional cell types can be derived from human pluripotent stem cells."}
{"query_id": "1097", "query_text": "Splenomegaly is observed in knockin mouse lacking the SHP-2 MAPK pathway.", "negative": "Guanine nucleotide exchange factors (GEFs) mediate RhoA activation in response to tensional forces on fibronectin-binding integrins.", "negatives": ["Guanine nucleotide exchange factors (GEFs) mediate RhoA activation in response to tensional forces on fibronectin-binding integrins.", "Measuring routine outcomes is more beneficial to clinical practice than assessing treatment adherence.", "N348I mutations reduce resistance to nevirapine.", "Reduction of Rpl38 alters the composition of the Hox gene mRNAs translation in mice without lowering overall protein synthesis.", "LSD1-positive promoters are associated with RNA polymerase II", "Asymptomatic visual impairment screening in elderly populations leads to improved vision.", "Broadly HIV-1 Neutralizing Antibodies (bnAb) 10EB have no affinity for phospholipids.", "The G34R/V mutation does not create a hypomethylated phenotype at the H3K36 histone.", "Thiopurine active metabolites can be catabolized through dephosphorylation of thioguanine nucleotides.", "Up-regulation of the p53 pathway and related molecular events speeds cancer progression."], "hard_negatives": ["Splenomegaly is observed in knockin mouse lacking the SHP-2 MAPK pathway.", "MUC1-C activates the NF-\u03baB p65 signaling pathway by interacting with I\u03baB kinase \u00df.", "Foxk2 regulates autophagy genes in muscle cells and fibroblast cells.", "The minor G allele of FOXO3 up-regulates IL-10.", "Foxp3 represses the expression of transcriptional regulators implicated in memory T cell development.", "Foxp3 enables the expression of transcriptional regulators implicated in memory T cell development.", "The minor G allele of FOXO3 downregulates pro-inflammatory cytokines.", "FoxO3a activation in neuronal death is inhibited by reactive oxygen species (ROS).", "Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes epithelial damage.", "Reducing H3k4me3 methylation induces mouse epiblast stem cells to naive pluripotency efficiently."], "hard_negative": "Splenomegaly is observed in knockin mouse lacking the SHP-2 MAPK pathway."}
{"query_id": "1098", "query_text": "Stacking is more stable when a purine is present in the +5 position (C1698).", "negative": "4-PBA treatment raises endoplasmic reticulum stress in response to general endoplasmic reticulum stress markers.", "negatives": ["4-PBA treatment raises endoplasmic reticulum stress in response to general endoplasmic reticulum stress markers.", "Activated Cdk5 phosphorylates the ATM protein in response to DNA damage.", "Bone Marrow (BM) transplantation is used to treat acute myeloid leukemia (AML)", "Decreased conversion of PGE 2 to PPARy ligand 15-ket-PGE 2 causes accumulation of PGE.", "Ly49Q directs the organization of neutrophil polarization by regulating membrane raft functions.", "Bariatric surgery increases rates of colorectal cancer.", "Tonic signaling from the scFv is amplified by MyD88/CD40.", "Taking anti-depresents is associated with a decrease in the A\u03b2 level in the brain of experimental animals.", "Sweet taste receptors on the tongue are deactivated by between 1 and 10 mM glucose.", "Hypocretin neurones suppress panicprone state in rats."], "hard_negatives": ["Stacking is more stable when a purine is present in the +5 position (C1698).", "mcm 5 s 2 U is required for proper decoding of NNR codons in eukaryotes.", "The recruitment of Wdr5 to its target loci depends on Kat8.", "Recognition of start codons depends on the translation initiation factor IF3.", "During non-homologous end joining, the ligation step is not as tolerant of disrepairs and other distortions when joining 5' of strand breaks as compared to 3' strand breaks.", "During non-homologous end joining, the ligation step is not as tolerant of disrepairs and other distortions when joining 3' of strand breaks as compared to 5' strand breaks.", "Replacement of histone H2A with H2A.Z accelerates gene activation in yeasts by destabilizing +1 nucleosomes.", "The H2A-H2B eviction defect is compensated for by other histone chaperone(s).", "r-protein chaperones are found in complexes with their r-protein binding partners.", "JMJD6 slows the hydroxylation of C-terminal lysine"], "hard_negative": "Stacking is more stable when a purine is present in the +5 position (C1698)."}
{"query_id": "1101", "query_text": "Stiff substrates encourage mesodermal differentiation by degrading beta-catenin in an integrin-dependent manner.", "negative": "Increased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm.", "negatives": ["Increased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm.", "Students who perform poorly in the early years of medical school are at increased risk for professional misconduct later in their careers.", "Individuals with Alzheimers who participate in six months of physical activity improve cognitive function for up to 18 months.", "IL-10 production by monocytes inhibits CD4 + T cell response.", "Human embryonic stem cells give rise to cell types from all three embryonic germ layers.", "Commelina yellow mottle virus (ComYMV) has three typical badnavirus ORFs, capable of encoding proteins 23, 15, and 216 kD.", "HIV trans-activator protein (TAT) effectively transports large and small molecules across cellular membranes into larger populations of neurons.", "Bone marrow cells don't contribute to adult macrophage compartments.", "Chinese individuals with TT homozygosity in the MTHFR gene are more vulnerable to strokes caused by low levels of folate intake.", "Asymptomatic visual impairment screening in elderly populations leads to improved vision."], "hard_negatives": ["Stiff substrates encourage mesodermal differentiation by degrading beta-catenin in an integrin-dependent manner.", "Stiff substrates inhibit mesodermal differentiation by degrading beta-catenin in an integrin-dependent manner.", "Intramembrane cleavage by signal peptide peptidase aids in the degradation of proteins with a complex membrane orientation.", "\u03b2-sheet opening occurs during pleurotolysin pore formation.", "Upregulation of dynein in Drosophila neurons increases the number of microtubule plus-ends growing toward the cell body of each neuron.", "Myelin sheaths are lipid-rich cellular structures.", "PRC1-bound plasmids sediment at a slower rate in unbound plasmids than in sucrose gradients.", "Differentiation of progenitor cells to myeloid cells is skewed when insulin signaling is suppressed.", "Pre-mRNAs associated with spliceosomal components are less stable than unassociated splicing substrates.", "Venules have less significant tunica adventitia than arterioles."], "hard_negative": "Stiff substrates encourage mesodermal differentiation by degrading beta-catenin in an integrin-dependent manner."}
{"query_id": "1102", "query_text": "Stiff substrates inhibit mesodermal differentiation by degrading beta-catenin in an integrin-dependent manner.", "negative": "IgA plasma cells that are specific for transglutaminase 2 are scarce in the duodenal mucosa of celiac disease patients when the disease is active.", "negatives": ["IgA plasma cells that are specific for transglutaminase 2 are scarce in the duodenal mucosa of celiac disease patients when the disease is active.", "Inhibiting HDAC6 increases survival of mice with ARID1A mutated tumors.", "De novo assembly of sequence data has shorter contigs than unassembled sequence data.", "Drosophila supracellular actomyosin structures are found at boundaries in wing imaginal discs.", "Activation of the Rac1 homolog CED-10 kills viable cells in SRGP-1 mutant Caenorhabditis elegans.", "Dexamethasone increases risk of postoperative bleeding.", "There is a relation between Erythromycin use and hypertrophic pyloric stenosis.", "The tissue surrounding the granuloma in an immune cell induces an anti-inflammatory immune response.", "Mouse models can be generated using \"artificial spermatids.\"", "Formation of N-terminal pyroglutamate by glutamine cyclase (GC) competes with NTAQ1 for Nt-Gln substrates."], "hard_negatives": ["Stiff substrates inhibit mesodermal differentiation by degrading beta-catenin in an integrin-dependent manner.", "Stiff substrates encourage mesodermal differentiation by degrading beta-catenin in an integrin-dependent manner.", "Intramembrane cleavage by signal peptide peptidase aids in the degradation of proteins with a complex membrane orientation.", "Myelin sheaths are lipid-rich cellular structures.", "\u03b2-sheet opening occurs during pleurotolysin pore formation.", "PRC1-bound plasmids sediment at a slower rate in unbound plasmids than in sucrose gradients.", "Upregulation of dynein in Drosophila neurons increases the number of microtubule plus-ends growing toward the cell body of each neuron.", "The microtubule-dependent delivery and secretion of matrix metalloproteases (MMPs) is partially responsible for the disassembly of adhesion sites.", "Inhibiting focal adhesion formation increases the rate at which cells convert mechanical strain into inflammation and fibrosis.", "Venules have less significant tunica adventitia than arterioles."], "hard_negative": "Stiff substrates inhibit mesodermal differentiation by degrading beta-catenin in an integrin-dependent manner."}
{"query_id": "1103", "query_text": "Stroke patients with prior use of direct oral anticoagulants have a higher risk of in-hospital mortality than stroke patients with prior use of warfarin.", "negative": "Omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegetarians.", "negatives": ["Omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegetarians.", "Pseudogene PTENP1 encodes a transcript that regulates PTEN expression.", "Low expression of miR7a does not repress target genes or exert a biological function in testis.", "1 in 5 million in UK have abnormal PrP positivity.", "De novo assembly of sequence data has fewer specific contigs than unassembled sequence data.", "Insulin effects appetite via ventral tegmental neurons.", "Bariatric surgery increases rates of colorectal cancer.", "Combination nicotine replacement therapies with varenicline or bupropion are more effective after 12 weeks of reatment compared to varenicline monotherapy.", "Androgenetic haploid mouse embryonic stem cells (ESCs) can be derived and genetically manipulated in vitro.", "Activated Cdk5 phosphorylates the ATM protein in response to DNA damage."], "hard_negatives": ["Stroke patients with prior use of direct oral anticoagulants have a higher risk of in-hospital mortality than stroke patients with prior use of warfarin.", "Side effects associated with antidepressants increases risk of stroke.", "Side effects associated with antidepressants do not represent a mortality risk to postmenopausal women.", "Side effects associated with antidepressants lower risk of myocardial infarction.", "Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission.", "Dexamethasone increases risk of postoperative bleeding.", "Systemic immunosuppressive (IS) therapy increases the chance of cancer mortality in patients with inflammatory eye disease (IED)", "Varenicline monotherapy is more effective after 26 weeks of treatment compared to combination nicotine replacement therapies with varenicline or bupropion.", "Antidepressants reduce the severity of migraines.", "Systemic immunosuppressive (IS) therapy does not enhance the chance of cancer mortality in patients with inflammatory eye disease (IED)"], "hard_negative": "Stroke patients with prior use of direct oral anticoagulants have a higher risk of in-hospital mortality than stroke patients with prior use of warfarin."}
{"query_id": "1105", "query_text": "Students who perform poorly in the early years of medical school are at increased risk for professional misconduct later in their careers.", "negative": "MICAL redox enzymes regulate actin dynamics.", "negatives": ["MICAL redox enzymes regulate actin dynamics.", "One in two surgical randomized controlled trials are discontinued early.", "The risk of cancer rises with level of alcohol consumption.", "CDK6 shows improved binding to loss-of-function variants of p18 INK4C.", "Glucose restriction to 0.05% reduces RLS (replicative life span) by 20-40% in S. cerevisiae.", "Obesity decreases life quality.", "The latent infection of myeloid cells with human cytomegalovirus induces a number of changes in gene expression.", "Bariatric surgery leads to positive outcomes in mental health.", "Overexpressing Cnp1 N-tail variants exacerbates the temperature-sensitive growth defect of scm3-139.", "Environmentally-induced senescence is mimicked in disease modeling by adding specific molecules to the culture system."], "hard_negatives": ["Students who perform poorly in the early years of medical school are at increased risk for professional misconduct later in their careers.", "Students who perform poorly in the early years of medical school are less likely to commit professional misconduct later in their careers.", "Misunderstandings between doctors and patients can lead to non-adherence.", "Risk-adjusted mortality rates are similar in teaching and non-teaching hospitals.", "Nigerian physicians constitue the largest component of sub-Saharan Africa-trained physicians in the United States.", "Assessing treatment adherence is more beneficial to clinical practice than measuring routine outcomes.", "Measuring routine outcomes is more beneficial to clinical practice than assessing treatment adherence.", "In young and middle-aged adults, current or remote uses of ADHD medications increase the risk of serious cardiovascular events.", "Side effects associated with antidepressants do not represent a mortality risk to postmenopausal women.", "Algerian physicians constitue the largest component of sub-Saharan Africa-trained physicians in the United States."], "hard_negative": "Students who perform poorly in the early years of medical school are at increased risk for professional misconduct later in their careers."}
{"query_id": "1106", "query_text": "Students who perform poorly in the early years of medical school are less likely to commit professional misconduct later in their careers.", "negative": "Radioiodine treatment of non-toxic multinodular goitre increases thyroid volume.", "negatives": ["Radioiodine treatment of non-toxic multinodular goitre increases thyroid volume.", "Lamins are associated with nuclear membrane structure maintenance.", "Integrating classroom-based collaborative learning with Web-based collaborative learning offers the best class performance.", "LSD1-positive promoters are associated with RNA polymerase II", "RTEL1 interacts with TRF2 through a C4C4 motif", "Fibroblast Growth Factor is a ligand which signals through receptor tyrosine kinases.", "Long - range chromatin interactions regulate transcription.", "Medications to treat obesity have unwanted side effects.", "Diabetic patients with acute coronary syndrome experience decreased short-term and long-term risk for bleeding events.", "Glucose restriction to 0.05% reduces RLS (replicative life span) by 20-40% in S. cerevisiae."], "hard_negatives": ["Students who perform poorly in the early years of medical school are less likely to commit professional misconduct later in their careers.", "Students who perform poorly in the early years of medical school are at increased risk for professional misconduct later in their careers.", "Misunderstandings between doctors and patients can lead to non-adherence.", "Risk-adjusted mortality rates are similar in teaching and non-teaching hospitals.", "Nigerian physicians constitue the largest component of sub-Saharan Africa-trained physicians in the United States.", "Assessing treatment adherence is more beneficial to clinical practice than measuring routine outcomes.", "Measuring routine outcomes is more beneficial to clinical practice than assessing treatment adherence.", "Side effects associated with antidepressants do not represent a mortality risk to postmenopausal women.", "In young and middle-aged adults, current or remote uses of ADHD medications increase the risk of serious cardiovascular events.", "Algerian physicians constitue the largest component of sub-Saharan Africa-trained physicians in the United States."], "hard_negative": "Students who perform poorly in the early years of medical school are less likely to commit professional misconduct later in their careers."}
{"query_id": "1109", "query_text": "Suboptimal nutrition is a leading cause of premature death", "negative": "70% of burn patients are admitted for hospitalization and further treatment after appearing at hospital emergency wards or outpatient clinics.", "negatives": ["70% of burn patients are admitted for hospitalization and further treatment after appearing at hospital emergency wards or outpatient clinics.", "Clathrin stabilizes the spindle fiber apparatus during mitosis.", "The morphology change from large white adipocytes to small brown adipocytes is a sign of decreased energy expenditure potential in white adipose tissue.", "Consumption of whole fruits increases the risk of type 2 diabetes.", "Blocking the interaction between TDP-43 and respiratory complex I proteins ND3 and ND6 prevents TDP-43-induced neuronal loss.", "Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 inhibit West Nile virus replication in cortical neurons.", "Sepsis related mortality has risen from 2009 to 2014.", "There is a positive correlation between hip fractures and statin use.", "A diminished ovarian reserve is a very strong indicator of infertility, even in an a priori non-infertile population.", "Replacement of histone H2A with H2A.Z accelerates gene activation in yeasts by destabilizing +1 nucleosomes."], "hard_negatives": ["Suboptimal nutrition is a leading cause of premature death", "53% of perinatal mortality is due to low birth weight.", "10% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.", "90% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.", "The mean suicide rate in women is higher after miscarriage than live birth.", "Obesity decreases life quality.", "Epidemiological disease burden from noncommunicable diseases is more prevalent in high economic settings.", "The mean suicide rate in women is lower after miscarriage than live birth.", "Autophagy deficiency in the liver increases vulnerability to insulin resistance.", "Elevated cell-free mitochondrial DNA levels are associated with mortality."], "hard_negative": "Suboptimal nutrition is a leading cause of premature death"}
{"query_id": "1111", "query_text": "Sudden death can occur in patients with complex ventricular arrhythmias.", "negative": "Having a main partner improves HIV outcomes.", "negatives": ["Having a main partner improves HIV outcomes.", "Mutations in RIM1 raise levels of IME1 RNA.", "RUNX is not expressed in skin tissue.", "Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection increases dissemination of Salmonella Typhimurium from the gut.", "Normal granulomas form in the absence of TNF in Zebrafish.", "The DdrB protein from Deinococcus radiodurans functions as a pentamer.", "Nonsteroidal antinflammatory drugs are ineffective as cancer treatments.", "Approximately 250,000 people are infected with human T-cell lymphotropic virus type 1 in the United Kingdom.", "Obesity decreases life quality.", "TRAP+ osteoclasts regulate mature osteoblast maintenance."], "hard_negatives": ["Sudden death can occur in patients with complex ventricular arrhythmias.", "Sudden death can occur in patients with orthostatic hypertension without cardiac conduction abnormalities.", "Decreased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm.", "Diabetic patients with acute coronary syndrome experience decreased short-term and long-term risk for bleeding events.", "Increased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm.", "90% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.", "10% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.", "Noninvasive positive pressure ventilation is not predictive of acute respiratory failure after solid organ transplantation.", "Migraine with aura is associated with ischemic stroke.", "Allogeneic mechanical circulatory support is not as effective as autologous mechanical circulatory support for treating acute myocardial infarction."], "hard_negative": "Sudden death can occur in patients with complex ventricular arrhythmias."}
{"query_id": "1112", "query_text": "Sudden death can occur in patients with orthostatic hypertension without cardiac conduction abnormalities.", "negative": "Immune complex triggered cell death leads to extracellular release of nuclear DNA.", "negatives": ["Immune complex triggered cell death leads to extracellular release of nuclear DNA.", "DUSP4 decreases apoptosis.", "Osteocytes have an essential role in G-CSF induced HSPC mobilization.", "Comparative transcriptome analysis identified new platelet proteins with structural features suggesting a role in platelet function.", "0-dimensional biomaterials lack inductive properties.", "Interleukin-18 plays an important role in the pathogenesis of atherosclerosis.", "Mice lacking Sirt1 in Sf1-expressing neurons have increased susceptibility to diet-induced obesity and insulin resistance.", "MT binding domain drives amyloid structure formation.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have decreased risk for dementia.", "IgA plasma cells that are specific for transglutaminase 2 are scarce in the duodenal mucosa of celiac disease patients when the disease is active."], "hard_negatives": ["Sudden death can occur in patients with orthostatic hypertension without cardiac conduction abnormalities.", "Sudden death can occur in patients with complex ventricular arrhythmias.", "Ambulatory blood pressure monitoring is inaccurate at diagnosing hypertension.", "Decreased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm.", "Increased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm.", "Diabetic patients with acute coronary syndrome experience decreased short-term and long-term risk for bleeding events.", "Nonhypertensive people who are 55 years old have a 90% chance of developing hypertension during their lifetime.", "In patients with congenital heart defects, \u03b2-blockers significantly improve clinical heart failure outcomes.", "CRP is positively correlated with postoperative mortality following Coronary Artery Bypass Graft (CABG) surgery.", "Risk of cardiovascular events can be cut by a third by using antihypertensive drug therapy among hemodialysis patients."], "hard_negative": "Sudden death can occur in patients with orthostatic hypertension without cardiac conduction abnormalities."}
{"query_id": "1114", "query_text": "Surfactin producing cells and exopolymer producing cells cooperate to generate \"Van Gogh\" bundles that have sliding abilities on specialized media.", "negative": "DRD1 proteins enable Pol V transcription in vivo.", "negatives": ["DRD1 proteins enable Pol V transcription in vivo.", "Increased conversion of PGE 2 to PPARy ligand 15-ket-PGE 2 causes accumulation of PGE.", "Blocking the interaction between TDP-43 and respiratory complex I proteins ND3 and ND6 prevents TDP-43-induced neuronal loss.", "Bone Marrow (BM) transplantation is used to treat acute myeloid leukemia (AML)", "Phase information is useful for predicting donor-recipient matches in organ transplantation.", "The TRaF1/C5 rs10818488 allele polymorphism regulates the neighboring C5 gene.", "Guanine nucleotide exchange factors (GEFs) mediate RhoA activation in response to tensional forces on fibronectin-binding integrins.", "32% of liver transplantation programs required patients to discontinue methadone treatment in 2001.", "Students who perform poorly in the early years of medical school are less likely to commit professional misconduct later in their careers.", "Ethanol stress increases the expression of SRL in bacteria."], "hard_negatives": ["Surfactin producing cells and exopolymer producing cells cooperate to generate \"Van Gogh\" bundles that have sliding abilities on specialized media.", "Inhibiting focal adhesion formation increases the rate at which cells convert mechanical strain into inflammation and fibrosis.", "0-dimensional biomaterials lack inductive properties.", "Inhibiting focal adhesion formation enables cells to convert mechanical strain into eventual scarring.", "The microtubule-dependent delivery and secretion of matrix metalloproteases (MMPs) is partially responsible for the disassembly of adhesion sites.", "Ca2+ cycling controls whole-body energy homeostasis in beige fat.", "Myelin sheaths play a role in action potential propagation.", "MICAL redox enzymes regulate actin dynamics in many cell types.", "The C-type lectin receptor (CLEC-2) rearranges the actin cytoskeleton in dendritic cells to promote efficient motility along stromal surfaces.", "Drosophila supracellular actomyosin structures are found at boundaries in wing imaginal discs."], "hard_negative": "Surfactin producing cells and exopolymer producing cells cooperate to generate \"Van Gogh\" bundles that have sliding abilities on specialized media."}
{"query_id": "1115", "query_text": "Surgical treatment is not superior to non-surgical in treating adults with displaced fractures of the proximal humerus.", "negative": "AZT given with ribavirin increases anemia.", "negatives": ["AZT given with ribavirin increases anemia.", "Perigenital skin is not the primary site of HIV acquisition.", "Genomic aberrations of metastases provide information for targeted therapy.", "MICAL redox enzymes regulate actin dynamics in many cell types.", "Mitochondria play a major role in apoptosis.", "Intra-cerebroventricular infusion of amyloid-\u03b2 oligomers reduces expression of fibronectin type-III domain-containing protein 5 mRNA in mice hippocampi.", "Aggravated inflammation is dependent on NLRP3 inflammasome activation.", "HOXB4 is a highly expressed component of cellular secretome from fetal liver cell populations.", "Malaria has a high vectorial capacity.", "There is no association between HNF4A mutations and diabetes risks."], "hard_negatives": ["Surgical treatment is not superior to non-surgical in treating adults with displaced fractures of the proximal humerus.", "The peak incidence of fractures occurs in toddlers.", "Osteoparthritis (OA) is characterized by degeneration of articular cartilage, joint edge, and subchondral bone hyperplasia.", "The peak incidence of fractures occurs during pubertal growth spurt in early adolescents.", "Rotator cuff exercises are more effective than general exercise therapy in reducing pain and improving function of the shoulder.", "General exercise therapy is more effective than rotator cuff exercises in reducing pain and improving function of the shoulder.", "General exercise therapy is more effective than scapular stabilizer exercises in reducing pain and improving function of the shoulder.", "Roughly 55% of women with chronic pelvic pain have no underlying pathology.", "Scapular stabilizer exercises are more effective than general exercise therapy in reducing pain and improving function of the shoulder.", "There is a positive correlation between hip fractures and statin use."], "hard_negative": "Surgical treatment is not superior to non-surgical in treating adults with displaced fractures of the proximal humerus."}
{"query_id": "1118", "query_text": "Sweet taste receptors on the tongue are deactivated by between 1 and 10 mM glucose.", "negative": "Surfactin producing cells and exopolymer producing cells cooperate to generate \"Van Gogh\" bundles that have sliding abilities on specialized media.", "negatives": ["Surfactin producing cells and exopolymer producing cells cooperate to generate \"Van Gogh\" bundles that have sliding abilities on specialized media.", "HIV trans-activator protein (TAT) effectively transports large and small molecules across cellular membranes into larger populations of neurons.", "Nigerian physicians constitue the largest component of sub-Saharan Africa-trained physicians in the United States.", "Men are more susceptible to death due to pneumonia when compared to women.", "Perigenital skin is not the primary site of HIV acquisition.", "Increased microtubule acetylation repairs interference of axonal transport caused by LRRK2 Roc-COR domain mutations.", "Genes regulated by Esrrb transcription factor are sensitive to Mbd3 function.", "Ethanol stress increases the expression of PSP in bacteria.", "Pioglitazone use is not associated with an increased risk of prostate cancer.", "Osteocytes have an essential role in G-CSF induced HSPC mobilization."], "hard_negatives": ["Sweet taste receptors on the tongue are deactivated by between 1 and 10 mM glucose.", "Insulin effects appetite via ventral tegmental neurons.", "Inhibiting glucose-6-phospate dehydrogenase improves lipogenesis by deactivating LKB1-AMPK signaling.", "The most prevalent adverse events to Semaglutide are gastrointestinal.", "Taxation of sugar-sweetened beverages reduced the incidence rate of type II diabetes in India.", "Moderate consumption of candy and chocolate reduces the risk of cardiovascular disease (CVD).", "It is not proven that moderate consumption of candy and chocolate reduces the risk of cardiovascular disease (CVD) specifically.", "Autophagy deficiency in the liver increases vulnerability to insulin resistance.", "Glucose restriction to 0.05% reduces RLS (replicative life span) by 20-40% in S. cerevisiae.", "Healthy volunteers exhibit rapid and transient increase of cellular ATP after being bolus-injected with fructose."], "hard_negative": "Sweet taste receptors on the tongue are deactivated by between 1 and 10 mM glucose."}
{"query_id": "1119", "query_text": "Sympathetic nerve activity is elevated throughout normal pregnancy.", "negative": "Gpr124 suppresses BBB breakdown in mouse models of ischemic stroke.", "negatives": ["Gpr124 suppresses BBB breakdown in mouse models of ischemic stroke.", "Ly49Q directs the organization of neutrophil polarization by regulating membrane raft functions.", "Low expression of miR7a does not repress target genes or exert a biological function in testis.", "ATM and Rad3 related protein have no role in sensing DNA damage.", "Ca2+ cycling is a UCP1-independent thermogenic mechanism.", "Reduced phosphorylation of PP2A suppresses HDAC4 dephosphorylation.", "Risk of cardiovascular events can be cut by a third by using antihypertensive drug therapy among hemodialysis patients.", "Vaccinating the gastrointestinal tract induces protection of rectal and vaginal mucosa.", "The mean suicide rate in women is higher after miscarriage than live birth.", "Epidemiological disease burden from noncommunicable diseases is more prevalent in high economic settings."], "hard_negatives": ["Sympathetic nerve activity is elevated throughout normal pregnancy.", "Sympathetic nerve activity is reduced throughout normal pregnancy.", "Glial calcium waves influence seizures.", "Sudden death can occur in patients with orthostatic hypertension without cardiac conduction abnormalities.", "Excess gestational weight gain is associated with obesity-related pregnancy outcomes.", "Vitamin D is an important factor in the relationship between calcium and parathyroid hormone.", "Insulin effects appetite via ventral tegmental neurons.", "Cardiac tissue-resident macrophages directly contribute to electrical activity.", "Increased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm.", "Lack of FGF21 in mice increases life expectancy."], "hard_negative": "Sympathetic nerve activity is elevated throughout normal pregnancy."}
{"query_id": "1120", "query_text": "Sympathetic nerve activity is reduced throughout normal pregnancy.", "negative": "Klf4 is not required for proper myeloid cell differentiation.", "negatives": ["Klf4 is not required for proper myeloid cell differentiation.", "Gpr124 suppresses BBB breakdown in mouse models of ischemic stroke.", "Long chain polyunsaturated fatty acids supplementation is associated with lower rates of atopic eczema at 1 year.", "Pyridostatin induces checkpoint activation.", "High levels of CRP lead to a higher risk of exacerbations in chronic obstructive pulmonary disease (COPD).", "Varenicline monotherapy is more effective after 26 weeks of treatment compared to combination nicotine replacement therapies with varenicline or bupropion.", "Combination nicotine replacement therapies with varenicline or bupropion are more effective after 12 weeks of reatment compared to varenicline monotherapy.", "Gastric lavage is an effective treatment for acute paraquat poisoning.", "Occipital activation levels are associated with auditory spatial performance in parietal regions of the brain.", "Klf2 is important for proper myeloid cell function."], "hard_negatives": ["Sympathetic nerve activity is reduced throughout normal pregnancy.", "Sympathetic nerve activity is elevated throughout normal pregnancy.", "Sudden death can occur in patients with orthostatic hypertension without cardiac conduction abnormalities.", "Excess gestational weight gain is associated with obesity-related pregnancy outcomes.", "Glial calcium waves influence seizures.", "The mean suicide rate in women is lower after miscarriage than live birth.", "The mean suicide rate in women is higher after miscarriage than live birth.", "Incidence of heart failure increased by 10% in women since 1979.", "Noninvasive positive pressure ventilation is not predictive of acute respiratory failure after solid organ transplantation.", "Lack of FGF21 in mice increases life expectancy."], "hard_negative": "Sympathetic nerve activity is reduced throughout normal pregnancy."}
{"query_id": "1125", "query_text": "Systemic immunosuppressive (IS) therapy does not enhance the chance of cancer mortality in patients with inflammatory eye disease (IED)", "negative": "BCL-2 promotes the apoptotic effects of c-Myc.", "negatives": ["BCL-2 promotes the apoptotic effects of c-Myc.", "Mutations in G-Beta protein GNB1 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.", "Surgical treatment is not superior to non-surgical in treating adults with displaced fractures of the proximal humerus.", "MT binding domain drives amyloid structure formation.", "In domesticated populations of Saccharomyces cerevisiae, segmental aneuploidy is very common.", "Taking anti-depresents is associated with a decrease in the A\u03b2 level in the brain of experimental animals.", "Comparative transcriptome analysis identified new platelet proteins with structural features suggesting a role in platelet function.", "Patients with microcytosis and higher erythrocyte count were more resistant to severe malarial anaemia when infected with Plasmodium falciparum.", "Distant CREs are important for transcriptional regulation.", "Increased mobility of retrotransposons is assosciated with mutation and higher tumorigenesis rates."], "hard_negatives": ["Systemic immunosuppressive (IS) therapy increases the chance of cancer mortality in patients with inflammatory eye disease (IED)", "Systemic immunosuppressive (IS) therapy does not enhance the chance of cancer mortality in patients with inflammatory eye disease (IED)", "Stroke patients with prior use of direct oral anticoagulants have a higher risk of in-hospital mortality than stroke patients with prior use of warfarin.", "Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission.", "Metastatic colorectal cancer treated with a single agent fluoropyrimidines resulted in similar efficacy and better quality of life when compared with oxaliplatin-based chemotherapy in elderly patients.", "Side effects associated with antidepressants increases risk of stroke.", "The most prevalent adverse events to Semaglutide are cardiovascular.", "The most prevalent adverse events to Semaglutide are gastrointestinal.", "Diabetic patients with acute coronary syndrome experience decreased short-term and long-term risk for bleeding events.", "Antimicrobial agents are less effective due to the pressure of antimicrobial usage."], "hard_negative": "Systemic immunosuppressive (IS) therapy increases the chance of cancer mortality in patients with inflammatory eye disease (IED)"}
{"query_id": "1126", "query_text": "Systemic immunosuppressive (IS) therapy increases the chance of cancer mortality in patients with inflammatory eye disease (IED)", "negative": "Tonic signaling from the scFv prevents constitutive stimulation.", "negatives": ["Tonic signaling from the scFv prevents constitutive stimulation.", "The PPR MDA5 has twenty N-terminal CARD domains.", "GATA3 regulates cell cycle progression in bone marrow hematopoietic stem cells.", "Pure neural progenitor cell (NPC) populations can only be obtained from cell cultures that undergo passaging, filtration, or other isolation and cell sorting methods.", "Pure neural progenitor cell (NPC) populations can only be obtained from cell cultures that undergo passaging, filtration, or other isolation and cell sorting methods.", "Incidence of sepsis has fallen substantially from 2009 to 2014.", "A low percentage of hematopoietic progenitor cells are susceptible to HIV-1 infection ex vivo.", "Sequence conservation in gene regulatory regions between species is a poor predictor of conserved functionality.", "FACT and other histone chaperone(s) compensate for Histone 2A (H2A)-histone 2B (H2B) dimer eviction during the histone exchange process.", "Upregulation of dynein in Drosophila neurons increases the number of microtubule plus-ends growing toward the cell body of each neuron."], "hard_negatives": ["Systemic immunosuppressive (IS) therapy increases the chance of cancer mortality in patients with inflammatory eye disease (IED)", "Systemic immunosuppressive (IS) therapy does not enhance the chance of cancer mortality in patients with inflammatory eye disease (IED)", "Stroke patients with prior use of direct oral anticoagulants have a higher risk of in-hospital mortality than stroke patients with prior use of warfarin.", "Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission.", "Side effects associated with antidepressants increases risk of stroke.", "Metastatic colorectal cancer treated with a single agent fluoropyrimidines resulted in similar efficacy and better quality of life when compared with oxaliplatin-based chemotherapy in elderly patients.", "Enhanced early production of inflammatory chemokines damages viral control in the lung.", "Antimicrobial agents are less effective due to the pressure of antimicrobial usage.", "Side effects associated with antidepressants lower risk of myocardial infarction.", "The most prevalent adverse events to Semaglutide are gastrointestinal."], "hard_negative": "Systemic immunosuppressive (IS) therapy increases the chance of cancer mortality in patients with inflammatory eye disease (IED)"}
{"query_id": "1127", "query_text": "Systemic lupus erythematosus is a risk factor for cardiovascular disease.", "negative": "Medications to treat obesity do not have side effects.", "negatives": ["Medications to treat obesity do not have side effects.", "Nonsteroidal antinflammatory drugs are ineffective as cancer treatments.", "Pioglitazone use is significantly associated with an increased risk of prostate cancer.", "Nonhypertensive people who are 55 years old have a 90% chance of developing hypertension during their lifetime.", "Formation of N-terminal pyroglutamate by glutamine cyclase (GC) competes with NTAQ1 for Nt-Gln substrates.", "Environmentally-induced senescence is mimicked in disease modeling by adding specific molecules to the culture system.", "Active Ly49Q prevents neutrophil polarization.", "The tissue surrounding the granuloma in an immune cell induces an anti-inflammatory immune response.", "DUSP4 decreases apoptosis.", "Folate and vitamin B12 levels influence the association between homocysteine and preeclampsia."], "hard_negatives": ["Systemic lupus erythematosus is a risk factor for cardiovascular disease.", "Risk of cardiovascular events can be cut by a third by using antihypertensive drug therapy among hemodialysis patients.", "Diabetic patients with acute coronary syndrome experience decreased short-term and long-term risk for bleeding events.", "CRP is positively correlated with postoperative mortality following Coronary Artery Bypass Graft (CABG) surgery.", "LDL cholesterol has a causal role in the development of cardiovascular disease.", "In young and middle-aged adults, current or remote uses of ADHD medications increase the risk of serious cardiovascular events.", "In British Men, haplogroup I increases risk of cardiovascular disease by 50%.", "Sudden death can occur in patients with complex ventricular arrhythmias.", "IL-6 signaling plays a major role in atherosclerotic cardiovascular disease.", "In British Men, haplogroup I decreases risk of cardiovascular disease."], "hard_negative": "Systemic lupus erythematosus is a risk factor for cardiovascular disease."}
{"query_id": "1128", "query_text": "T cell receptor /CD3 microdomains are required to induce the immunologic synapse.", "negative": "R2D2 stops miRNA production by increasing the selectivity of Dcr2 for long dsRNA.", "negatives": ["R2D2 stops miRNA production by increasing the selectivity of Dcr2 for long dsRNA.", "Antidepressants increase the severity of migraines.", "Splenomegaly is observed in knockin mouse lacking the SHP-2 MAPK pathway.", "B3-Galectin increases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR.", "A single nucleotide variant the gene DGKK is strongly associated with increased risk of hypospadias.", "During non-homologous end joining, the ligation step is not as tolerant of disrepairs and other distortions when joining 3' of strand breaks as compared to 5' strand breaks.", "Sn is present on mature DCs during inflammation in vivo.", "4-PBA treatment decreases endoplasmic reticulum stress in response to general endoplasmic reticulum stress markers.", "Cost effectiveness evaluations based on cRCT data accurately reflect prices for patients in actual clinical practice.", "Intra-cerebroventricular infusion of amyloid-\u03b2 oligomers reduces expression of fibronectin type-III domain-containing protein 5 mRNA in mice hippocampi."], "hard_negatives": ["T cell receptor /CD3 microdomains are required to induce the immunologic synapse.", "Major antigen-induced signals from the T cell receptor and secondary signals from costimulatory receptors are required for T cell activation.", "ITAM phosphorylation allows for the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).", "CD28 signals regulate trafficking of murine auto-reactive T cells into target tissues.", "Egr3 regulates the homeostasis of B and T cells.", "Many transmembrane receptors transmit signals by long-range conformational changes in the association of alpha-helices across the plasma membrane.", "Egr2 regulates the homeostasis of B and T cells.", "Reduced responsiveness to interleukin-2 in regulatory T cells is associated with autoimmune diseases such as Type 1 Diabetes.", "Peroxynitrite is required for induction of T cell tolerance.", "The density of cytokine receptor bearing cells affects the distance over which cytokines act."], "hard_negative": "T cell receptor /CD3 microdomains are required to induce the immunologic synapse."}
{"query_id": "1133", "query_text": "TMEM27 is a marker for beta cells.", "negative": "C2 works synergistically with A-769662 to activate dephosphorylated AMPK.", "negatives": ["C2 works synergistically with A-769662 to activate dephosphorylated AMPK.", "V-9302 inhibits antitumor responses by decreasing cell death and oxidative stress.", "Genes involved in pre-mRNA splicing have a significant impact on genome stability.", "Occipital activation levels are associated with auditory spatial performance in parietal regions of the brain.", "Lysine histone demethylase inhibitor JIB 04 is inactive against KDM5A.", "Increased lipolysis leads to higher P38 phosphorylation in adipose tissue.", "Mutant mice lacking SVCT2 have severely reduced ascorbic acid levels in both brain and adrenals.", "Sequence conservation in gene regulatory regions between species is a poor predictor of conserved functionality.", "Type 1 Diabetes is associated with subtle perturbations in T reg development.", "The density of cytokine receptor bearing cells has no effect on the distance over which cytokines act."], "hard_negatives": ["TMEM27 is a marker for beta cells.", "Egr3 regulates the homeostasis of B and T cells.", "Egr2 regulates the homeostasis of B and T cells.", "Foxp3 enables the expression of transcriptional regulators implicated in memory T cell development.", "Foxp3 represses the expression of transcriptional regulators implicated in memory T cell development.", "IL-10 production by monocytes inhibits CD4 + T cell response.", "CD28 signals regulate trafficking of murine auto-reactive T cells into target tissues.", "Major antigen-induced signals from the T cell receptor and secondary signals from costimulatory receptors are required for T cell activation.", "Many transmembrane receptors transmit signals by long-range conformational changes in the association of alpha-helices across the plasma membrane.", "Foxk2 regulates autophagy genes in muscle cells and fibroblast cells."], "hard_negative": "TMEM27 is a marker for beta cells."}
{"query_id": "1134", "query_text": "TNFAIP3 is a glioblastoma tumor enhancer.", "negative": "The M2-phenotype in brown adipose tissue macrophages increases brown adipose tissue thermogenic activity.", "negatives": ["The M2-phenotype in brown adipose tissue macrophages increases brown adipose tissue thermogenic activity.", "In breast cancer, the loss of myoepithelial cells promotes the transition of ductal carcinoma in situ to invasive carcinoma.", "Activation of the Rac1 homolog CED-10 kills viable cells in SRGP-1 mutant Caenorhabditis elegans.", "Omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegans.", "The DESMOND program caused substantial weight loss in most participants.", "Cytosolic proteins bind to iron-responsive elements on mRNAs coding for TFRC1.", "Reduction of purity of cytoplasmic membranes isolated from overexpressors is indicated by stronger spots for OmpF in 2D BN-PAGE gels.", "BLM gene encodes RecQ-class DNA helicase.", "Carriers of HNF4A mutations are at reduced risk for diabetes.", "Piezo1 channels are sensors for cell migration in epithelial cells."], "hard_negatives": ["TNFAIP3 is a glioblastoma tumor suppressor.", "TNFAIP3 is a glioblastoma tumor enhancer.", "TNFAIP3 is a tumor enhancer in glioblastoma.", "GATA3 regulates cell cycle progression in bone marrow hematopoietic stem cells.", "MafA phosphorylation enhances its ubiquitination.", "Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes fibrosis.", "Foxp3 represses the expression of transcriptional regulators implicated in memory T cell development.", "GATA3 regulates self-renewal capacity in bone marrow hematopoietic stem cells.", "Foxp3 enables the expression of transcriptional regulators implicated in memory T cell development.", "ALDH1 expression is associated with poorer prognosis for breast cancer primary tumors."], "hard_negative": "TNFAIP3 is a glioblastoma tumor suppressor."}
{"query_id": "1135", "query_text": "TNFAIP3 is a glioblastoma tumor suppressor.", "negative": "Depletion of nitric oxide is responsible for vasospasm.", "negatives": ["Depletion of nitric oxide is responsible for vasospasm.", "The DESMOND program demonstrates no significant impact on biochemical outcomes.", "Cyclin A2 destruction is necessary to switch from unstable to stable kt-mt attachments in mitosis.", "The relationship between a breast cancer patient's capacity to metabolize tamoxifen and treatment outcome is independent of the patient's genetic make-up.", "Eliminating the last sporadic cases of malaria requires considerable funding.", "Low expression of miR7a does not repress target genes or exert a biological function in ovaries.", "Comparative transcriptome analysis identified new platelet proteins with structural features suggesting a role in platelet function.", "ATM and Rad3 related protein are critical for sensing DNA damage.", "Removal of H3K9me3 by ectopic expression of other H3K9 demethylases improves reprogramming efficiency in SCNT experiments.", "ERAP1 SNPs are epistatic to HLA alleles for ankylosing spondylitis."], "hard_negatives": ["TNFAIP3 is a glioblastoma tumor suppressor.", "TNFAIP3 is a glioblastoma tumor enhancer.", "TNFAIP3 is a tumor enhancer in glioblastoma.", "GATA3 regulates cell cycle progression in bone marrow hematopoietic stem cells.", "Foxp3 represses the expression of transcriptional regulators implicated in memory T cell development.", "Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes fibrosis.", "The minor G allele of FOXO3 up-regulates IL-10.", "Foxp3 enables the expression of transcriptional regulators implicated in memory T cell development.", "GATA3 regulates self-renewal capacity in bone marrow hematopoietic stem cells.", "MafA phosphorylation enhances its ubiquitination."], "hard_negative": "TNFAIP3 is a glioblastoma tumor suppressor."}
{"query_id": "1136", "query_text": "TNFAIP3 is a tumor enhancer in glioblastoma.", "negative": "Microglia are an innate immune cell type of the peripheral nervous system.", "negatives": ["Microglia are an innate immune cell type of the peripheral nervous system.", "LRBA prevents CTLA - 4 recycling.", "The DESMOND program demonstrates no significant impact on biochemical outcomes.", "Differentiation of progenitor cells to myeloid cells is skewed when insulin signaling is suppressed.", "The World Health Organization's (WHO) data collection process is biased downward by unequal selection of larger outbreaks.", "In young and middle-aged adults, current or remote uses of ADHD medications increase the risk of serious cardiovascular events.", "KRT17 modulates the expression of the transcriptional regulator AIRE in diseased epithelia.", "1-1% of colorectal cancer patients are diagnosed with regional or distant metastases.", "A diminished ovarian reserve is a very strong indicator of infertility, even in an a priori non-infertile population.", "L3MBTL2 binds to H2AK119Ub marked chromatin to form a PRC1 complex."], "hard_negatives": ["TNFAIP3 is a glioblastoma tumor suppressor.", "TNFAIP3 is a glioblastoma tumor enhancer.", "TNFAIP3 is a tumor enhancer in glioblastoma.", "GATA3 regulates cell cycle progression in bone marrow hematopoietic stem cells.", "Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes fibrosis.", "MafA phosphorylation enhances its ubiquitination.", "Foxp3 represses the expression of transcriptional regulators implicated in memory T cell development.", "ALDH1 expression is associated with poorer prognosis for breast cancer primary tumors.", "Foxp3 enables the expression of transcriptional regulators implicated in memory T cell development.", "GATA3 regulates self-renewal capacity in bone marrow hematopoietic stem cells."], "hard_negative": "TNFAIP3 is a glioblastoma tumor suppressor."}
{"query_id": "1138", "query_text": "TRAP+ osteoclasts regulate mature osteoblast maintenance.", "negative": "Pro-inflammatory cytokines are up regulated during tumor development.", "negatives": ["Pro-inflammatory cytokines are up regulated during tumor development.", "5'-nucleotidase metabolizes 6MP.", "Crossover hot spots are found within gene promoters in Saccharomyces cerevisiae.", "Decreased conversion of PGE 2 to PPARy ligand 15-ket-PGE 2 causes accumulation of PGE.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have increased risk for Alzheimer's disease.", "Commelina yellow mottle virus' (ComYMV) genome consists of 2140 baise pairs.", "Having a main partner improves HIV outcomes.", "H4 G94P proteins inhibit chromatin assembly, which decreases free histones.", "PGE 2 suppresss intestinal tumor growth by altering the expression of tumor suppressing and DNA repair genes.", "CDK6 shows improved binding to loss-of-function variants of p18 INK4C."], "hard_negatives": ["TRAP+ osteoclasts regulate mature osteoblast maintenance.", "F4/80+ macrophages regulate mature osteoblast maintenance.", "Osteoparthritis (OA) is characterized by degeneration of articular cartilage, joint edge, and subchondral bone hyperplasia.", "Osteocytes have an essential role in G-CSF induced HSPC mobilization.", "The microtubule-dependent delivery and secretion of matrix metalloproteases (MMPs) is partially responsible for the disassembly of adhesion sites.", "MT binding domain drives amyloid structure formation.", "Allogeneic mechanical circulatory support is not as effective as autologous mechanical circulatory support for treating acute myocardial infarction.", "Intramembrane cleavage by signal peptide peptidase aids in the degradation of proteins with a complex membrane orientation.", "Induction of urokinase receptor signaling in podocytes causes foot process effacement and proteinuria.", "MFGE8 regulates fat absorption by binding to av-Beta3 and av-Beta5 integrins."], "hard_negative": "TRAP+ osteoclasts regulate mature osteoblast maintenance."}
{"query_id": "1139", "query_text": "Taking 400mg of \u03b1-tocopheryl acetate does not prevent prostate cancer.", "negative": "Noninvasive positive pressure ventilation is not predictive of acute respiratory failure after solid organ transplantation.", "negatives": ["Noninvasive positive pressure ventilation is not predictive of acute respiratory failure after solid organ transplantation.", "cSMAC formation represses weak ligand signalling.", "Lack of FGF21 in mice leads to reduced lifespan.", "Misunderstandings between doctors and patients can lead to non-adherence.", "Inhibiting focal adhesion formation enables cells to convert mechanical strain into eventual scarring.", "Tirasemtiv targets fast-twitch muscle.", "Side effects associated with antidepressants do not represent a mortality risk to postmenopausal women.", "Algerian physicians constitue the largest component of sub-Saharan Africa-trained physicians in the United States.", "The tip of the inner tube of the toxic type VI secretion system (T6SS) antibacterial effector in Escherichia coli (E. coli) is decorated with VgrG and PAAR proteins.", "Gastric infection with Helicobacter pylori increases risk of gastric cancer in humans."], "hard_negatives": ["Taking 400mg of \u03b1-tocopheryl acetate does not prevent prostate cancer.", "Taking 400mg of \u03b1-tocopheryl acetate in combination with vitamin C reduces the risk of prostate cancer.", "Pioglitazone use is not associated with an increased risk of prostate cancer.", "Pioglitazone use is significantly associated with an increased risk of prostate cancer.", "Pioglitazone use is significantly associated with an increased risk of pancreatic cancer.", "Sildenafil worsens erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.", "Decrease of p62 in prostate tumor stroma results in defective autophagy.", "Increase of p62 in prostate tumor stroma results in defective autophagy.", "A breast cancer patient's capacity to metabolize tamoxifen influences treatment outcome.", "Ten percent (10%) of kidney cancers in the UK are attributable to excess weight."], "hard_negative": "Taking 400mg of \u03b1-tocopheryl acetate does not prevent prostate cancer."}
{"query_id": "1141", "query_text": "Taking 400mg of \u03b1-tocopheryl acetate in combination with vitamin C reduces the risk of prostate cancer.", "negative": "Induced hepatic stem cells possess the potential to differentiate into cholangiocytic cells.", "negatives": ["Induced hepatic stem cells possess the potential to differentiate into cholangiocytic cells.", "NR5A2 is important in reverse cholesterol transport in humans.", "A diminished ovarian reserve does not solely indicate infertility in an a priori non-infertile population.", "Monoclonal antibody targeting of N-cadherin inhibits castration resistance.", "Mitochondria play a major role in energy production.", "Sepsis related mortality has risen from 2009 to 2014.", "The appearance of brown-like or beige cells primarily occurs in visceral fat, not subcutaneous fat.", "Cognitive behavioral therapy is an ineffective treatment for insomnia", "Bone marrow cells don't contribute to adult macrophage compartments.", "Upregulation of PD1 causes the upregulation of Satb1."], "hard_negatives": ["Taking 400mg of \u03b1-tocopheryl acetate in combination with vitamin C reduces the risk of prostate cancer.", "Taking 400mg of \u03b1-tocopheryl acetate does not prevent prostate cancer.", "Pioglitazone use is not associated with an increased risk of prostate cancer.", "Pioglitazone use is significantly associated with an increased risk of prostate cancer.", "Pioglitazone use is significantly associated with an increased risk of pancreatic cancer.", "Sildenafil worsens erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.", "A breast cancer patient's capacity to metabolize tamoxifen influences treatment outcome.", "Ten percent (10%) of kidney cancers in the UK are attributable to excess weight.", "Dexamethasone increases risk of postoperative bleeding.", "Decrease of p62 in prostate tumor stroma results in defective autophagy."], "hard_negative": "Taking 400mg of \u03b1-tocopheryl acetate in combination with vitamin C reduces the risk of prostate cancer."}
{"query_id": "1142", "query_text": "Taking anti-depresents is associated with a decrease in the A\u03b2 level in the brain of experimental animals.", "negative": "PKG-la does not have a large impact on expression of spinal long term potentiation in PGK-la knockout mice.", "negatives": ["PKG-la does not have a large impact on expression of spinal long term potentiation in PGK-la knockout mice.", "Increased purity of cytoplasmic membranes isolated from overexpressors is indicated by stronger spots for OmpF in 2D BN-PAGE gels.", "Taxation of sugar-sweetened beverages reduced the incidence rate of type II diabetes in India.", "Reduction of purity of cytoplasmic membranes isolated from overexpressors is indicated by stronger spots for OmpA in 2D BN-PAGE gels.", "Upregulation of PD1 causes the upregulation of Satb1.", "Propriospinal interneurons that play a role in the plastic reorganization of spinal circuits are integral for recovery from spinal cord injury.", "Pseudogene PTENP1 encodes a transcript that regulates PTEN expression.", "Inhibiting glucose-6-phospate dehydrogenase improves lipogenesis by deactivating LKB1-AMPK signaling.", "Surfactin producing cells and exopolymer producing cells cooperate to generate \"Van Gogh\" bundles that have sliding abilities on specialized media.", "Pseudoknots are not evolutionarily conserved in most eukaryotes."], "hard_negatives": ["Taking anti-depresents is associated with a decrease in the A\u03b2 level in the brain of experimental animals.", "Side effects associated with antidepressants increases risk of stroke.", "In patients with congenital heart defects, \u03b2-blockers significantly improve clinical heart failure outcomes.", "Side effects associated with antidepressants lower risk of myocardial infarction.", "The most prevalent adverse events to Semaglutide are cardiovascular.", "The most prevalent adverse events to Semaglutide are gastrointestinal.", "Antiretroviral therapy increases rates of tuberculosis across a broad range of CD4 strata.", "Side effects associated with antidepressants do not represent a mortality risk to postmenopausal women.", "Antidepressants increase the severity of migraines.", "Exhaustion of B cells contributes to poor Ab response in HIV-infected individuals."], "hard_negative": "Taking anti-depresents is associated with a decrease in the A\u03b2 level in the brain of experimental animals."}
{"query_id": "1145", "query_text": "Taxation of sugar-sweetened beverages reduced the incidence rate of type II diabetes in India.", "negative": "Patients with microcytosis and higher erythrocyte count were more resistant to severe malarial anaemia when infected with Plasmodium falciparum.", "negatives": ["Patients with microcytosis and higher erythrocyte count were more resistant to severe malarial anaemia when infected with Plasmodium falciparum.", "HAND2 methylation is a key step in early endometrial carcinogenesis.", "DRD1 proteins enable Pol V transcription in vivo.", "Radioiodine treatment of non-toxic multinodular goitre increases thyroid volume.", "The gene daf-16, which encodes forkhead Box O (FOXO), is required for all phenotypes associated with reduced insulin/insulin-like growth factor (Igf) signaling.", "Ultrasound guidance significantly reduces the number of traumatic procedures when attempting needle insertion.", "Anthrax spores are very difficult to dispose once they are dispersed.", "TNFAIP3 is a tumor enhancer in glioblastoma.", "Cost effectiveness evaluations based on cRCT data lack external validity.", "Microglia are an innate immune cell type of the peripheral nervous system."], "hard_negatives": ["Taxation of sugar-sweetened beverages reduced the incidence rate of type II diabetes in India.", "Consumption of whole fruits increases the risk of type 2 diabetes.", "It is not proven that moderate consumption of candy and chocolate reduces the risk of cardiovascular disease (CVD) specifically.", "Moderate consumption of candy and chocolate reduces the risk of cardiovascular disease (CVD).", "Autophagy deficiency in the liver increases vulnerability to insulin resistance.", "Exercise increases cancer mortality rates among Chinese citizens.", "Exercise reduces cancer mortality rates among Chinese citizens.", "The risk of cancer rises with level of alcohol consumption.", "Medications to treat obesity have unwanted side effects.", "Reduced levels of lipolysis leads to higher P38 phosphorylation in adipose tissue."], "hard_negative": "Taxation of sugar-sweetened beverages reduced the incidence rate of type II diabetes in India."}
{"query_id": "1148", "query_text": "Ten percent (10%) of kidney cancers in the UK are attributable to excess weight.", "negative": "LRBA promotes CTLA - 4 recycling.", "negatives": ["LRBA promotes CTLA - 4 recycling.", "BiP is a general endoplasmic reticulum stress marker.", "Glycan adaptation is rarely observed in the B-cell repertoire.", "During non-homologous end joining, the ligation step is not as tolerant of disrepairs and other distortions when joining 3' of strand breaks as compared to 5' strand breaks.", "Distant CREs are important for transcriptional regulation.", "Insulin decreases risk of severe kidney failure.", "Removal of H3K9me3 by ectopic expression of other H3K9 demethylases decreases reprogramming efficiency in SCNT experiments.", "MafA ubiquitination decreases the recruitment of coavtivator P/CAF by MafA.", "Primary cervical cytology screening with HPV detection has higher longitudinal sensitivity to detect severe cervical intraepithelial neoplasia than conventional cytology.", "Binding of p53 to enhancer regions (p53BERs) regulates the activity of p53 transcription and cell cycle arrest through the production of p53-dependent eRNAs."], "hard_negatives": ["Ten percent (10%) of kidney cancers in the UK are attributable to excess weight.", "Women with a lower birth weight are more likely to develop breast cancer later in life.", "61% of colorectal cancer patients are diagnosed with regional or distant metastases.", "1-1% of colorectal cancer patients are diagnosed with regional or distant metastases.", "Birth-weight is negatively associated with breast cancer.", "The risk of breast cancer among parous women decreases with placental weight of pregnancies.", "In British Men, haplogroup I increases risk of cardiovascular disease by 50%.", "Environmental factors can influence the development of breast cancer.", "In breast cancer, the loss of myoepithelial cells promotes the transition of ductal carcinoma in situ to invasive carcinoma.", "In British Men, haplogroup I decreases risk of cardiovascular disease."], "hard_negative": "Ten percent (10%) of kidney cancers in the UK are attributable to excess weight."}
{"query_id": "1153", "query_text": "The C-type lectin receptor (CLEC-2) rearranges the actin cytoskeleton in dendritic cells to promote efficient motility along stromal surfaces.", "negative": "Migraine with aura is associated with ischemic stroke.", "negatives": ["Migraine with aura is associated with ischemic stroke.", "Sudden death can occur in patients with orthostatic hypertension without cardiac conduction abnormalities.", "Mouse models can be generated using \"artificial spermatids.\"", "Physical activity level is associated with the difference in maximal oxygen consumption between black and white youth.", "Assessing treatment adherence is more beneficial to clinical practice than measuring routine outcomes.", "Obesity raises life quality.", "Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 encourage West Nile virus replication in cortical neurons.", "IFI16 impedes STING phosphorylation and translocation, resulting in reduced activation of STING.", "Medications to treat obesity have unwanted side effects.", "JMJD6 slows the hydroxylation of C-terminal lysine"], "hard_negatives": ["The C-type lectin receptor (CLEC-2) rearranges the actin cytoskeleton in dendritic cells to promote efficient motility along stromal surfaces.", "The PDPN gene deactivates the C-type lectin receptor (CLEC-2).", "Fibroblast Growth Factor is a ligand which signals through receptor tyrosine kinases.", "Kir7.1 modulates channel activity by the G protein-coupled melanocortin-4 receptor (MC4R) in the paraventricular nucleus of the hypothalamus.", "MICAL redox enzymes regulate actin dynamics in many cell types.", "Drosophila supracellular actomyosin structures are found at boundaries in wing imaginal discs.", "Guanine nucleotide exchange factors (GEFs) mediate RhoA activation in response to tensional forces on fibronectin-binding integrins.", "ITAM phosphorylation allows for the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).", "Upregulation of dynein in Drosophila neurons increases the number of microtubule plus-ends growing toward the cell body of each neuron.", "RTEL1 interacts with TRF2 through a C4C4 motif"], "hard_negative": "The C-type lectin receptor (CLEC-2) rearranges the actin cytoskeleton in dendritic cells to promote efficient motility along stromal surfaces."}
{"query_id": "1156", "query_text": "The DESMOND program caused substantial weight loss in most participants.", "negative": "Increased lipolysis leads to higher P38 phosphorylation in adipose tissue.", "negatives": ["Increased lipolysis leads to higher P38 phosphorylation in adipose tissue.", "RUNX1 is downregulated or mutated in TLX1 T-ALL.", "Mice lacking Sirt1 in Sf1-expressing neurons have increased susceptibility to diet-induced obesity and insulin resistance.", "The artifactual C-terminal helix swapping in the StART domain is observed in the Ups1-Mdm35 heterodimer of the StARkin superfamily.", "Human embryonic stem cells give rise to cell types from the outer embryonic germ layer, but not the other two layers.", "In S. cerevisiae, the absence of RNA surveillance pathways reduces sensitivity to high iron conditions.", "Pseudogene PTENP1 encodes a transcript that regulates PTEN expression.", "Deleting Raptor increases G-CSF levels.", "Elevated cell-free mitochondrial DNA levels are associated with mortality.", "50% of patients exposed to radiation have activated markers of mesenchymal stem cells."], "hard_negatives": ["The DESMOND program caused substantial weight loss in most participants.", "The DESMOND program demonstrates no significant impact on weight loss.", "The DESMOND program demonstrates no significant impact on lifestyles outcomes.", "The DESMOND program demonstrates no significant impact on biochemical outcomes.", "Excess gestational weight gain is associated with obesity-related pregnancy outcomes.", "Input from  mental and physical health care professionals is not effective at decreasing homelessness.", "32% of liver transplantation programs required patients to discontinue methadone treatment in 2001.", "Dexamethasone increases risk of postoperative bleeding.", "Individuals with Alzheimers who participate in six months of physical activity improve cognitive function for up to 18 months.", "Participants who quit smoking reduce lung cancer risk by approximately 50%."], "hard_negative": "The DESMOND program caused substantial weight loss in most participants."}
{"query_id": "1157", "query_text": "The DESMOND program demonstrates no significant impact on biochemical outcomes.", "negative": "Reduced phosphorylation of PP2A suppresses HDAC4 dephosphorylation.", "negatives": ["Reduced phosphorylation of PP2A suppresses HDAC4 dephosphorylation.", "In pediatric tissue, most T cells are naive T cell emigrants from the thymus.", "Origin gross domestic product(GDP) is positively related to dengue virus (DENV-1) diffusion in air traffic shipments.", "APOE4 expression in iPSC-derived neurons results in decreased tau phosphorylation.", "Foxp3 represses the expression of transcriptional regulators implicated in memory T cell development.", "Incidence of heart failure increased by 10% in women since 1979.", "p16INK4A degradation is  linked to an abnormal wound response caused by the microinvasive step of advanced Oral Potentially Malignant Lesions (OPMLs).", "Physical activity level has no association with the difference in maximal oxygen consumption between black and white youth.", "Early patent ductus ateriosus (PDA) screening decreases in-hospital mortality.", "miR-142-5P is a known regulator of raised body temperature."], "hard_negatives": ["The DESMOND program demonstrates no significant impact on biochemical outcomes.", "The DESMOND program demonstrates no significant impact on lifestyles outcomes.", "The DESMOND program demonstrates no significant impact on weight loss.", "The DESMOND program caused substantial weight loss in most participants.", "Cost effectiveness evaluations based on cRCT data lack external validity.", "Therapeutics receiving accelerated approval encounter a lower frequency of post-marketing safety events", "Cost effectiveness evaluations based on cRCT data accurately reflect prices for patients in actual clinical practice.", "There is no association between HNF4A mutations and diabetes risks.", "Androgenetic haploid mouse embryonic stem cells (ESCs) can be derived and genetically manipulated in vitro.", "Measuring routine outcomes is more beneficial to clinical practice than assessing treatment adherence."], "hard_negative": "The DESMOND program demonstrates no significant impact on biochemical outcomes."}
{"query_id": "1158", "query_text": "The DESMOND program demonstrates no significant impact on lifestyles outcomes.", "negative": "Students who perform poorly in the early years of medical school are at increased risk for professional misconduct later in their careers.", "negatives": ["Students who perform poorly in the early years of medical school are at increased risk for professional misconduct later in their careers.", "miR-142-5P is a known regulator of raised body temperature.", "Mice defective for deoxyribonucleic acid (DNA) polymerase m (polm) reveal increased sensitivity to ionizing radiation (IR).", "Neutrophils produce IL-1\u03b2 in response to large particles.", "Increased conversion of PGE 2 to PPARy ligand 15-ket-PGE 2 causes accumulation of PGE.", "Destination container port throughput(CPT) is negatively related to dengue virus (DENV-1) diffusion in air traffic shipments.", "Adult tissue-resident macrophages stem from the embryonal yolk sac and fetal liver.", "The repeat-variable diresidue (RVD) in the loop of Transcription-Activator Like (TAL) effectors specifies the nucleotides-amino acid contact at the target promoter element.", "PRC1-bound plasmids sediment at a slower rate in unbound plasmids than in sucrose gradients.", "Helminths interfere with immune system control of coinfections by microbial pathogens 16."], "hard_negatives": ["The DESMOND program demonstrates no significant impact on lifestyles outcomes.", "The DESMOND program demonstrates no significant impact on weight loss.", "The DESMOND program demonstrates no significant impact on biochemical outcomes.", "The DESMOND program caused substantial weight loss in most participants.", "Input from  mental and physical health care professionals is not effective at decreasing homelessness.", "Integrated care is ineffective at tackling multiple comorbidities.", "Incidence of 10/66 dementia is lower than the incidence of DSM-IV dementia.", "Integrated care is successful at tackling multiple comorbidities.", "Self-advocacy training is effective at decreasing homelessness.", "Incidence of 10/66 dementia is higher than the incidence of DSM-IV dementia."], "hard_negative": "The DESMOND program demonstrates no significant impact on lifestyles outcomes."}
{"query_id": "1159", "query_text": "The DESMOND program demonstrates no significant impact on weight loss.", "negative": "MT binding domain drives amyloid structure formation.", "negatives": ["MT binding domain drives amyloid structure formation.", "Cancers that initially benefit from epidermal growth factor receptor targeted therapies later become refractory through several mechanisms.", "In transgenic mice harboring green florescent protein under the control of the Sox2 promoter, more than 50 percent of the cells with green florescent colocalize with cell proliferation markers.", "PKG-la plays an essential role in expression of spinal long term potentiation in PGK-la knockout mice.", "Rapid phosphotransfer rates are correlated with histidine kinase regulator specificity.", "Bariatric surgery leads to negative outcomes in mental health.", "Toll-like receptor (TLR) signaling is involved in the pathogenesis of human MDS.", "Weighed food records (WFR) result in high completion since they're cheap to run and impose low participant burden.", "Genetic deficiency of mast cells leads to decreased weight gain in a mouse model of diet-induced obesity.", "aPKCz causes tumour suppression by affecting glutamine metabolism."], "hard_negatives": ["The DESMOND program demonstrates no significant impact on weight loss.", "The DESMOND program caused substantial weight loss in most participants.", "The DESMOND program demonstrates no significant impact on lifestyles outcomes.", "The DESMOND program demonstrates no significant impact on biochemical outcomes.", "Excess gestational weight gain is associated with obesity-related pregnancy outcomes.", "There is no association between HNF4A mutations and diabetes risks.", "For every 1,000 children with cerebral palsy, more than 300 of them are premature or underweight at birth.", "Input from  mental and physical health care professionals is not effective at decreasing homelessness.", "Individuals with Alzheimers who participate in six months of physical activity improve cognitive function for up to 18 months.", "Medications to treat obesity do not have side effects."], "hard_negative": "The DESMOND program demonstrates no significant impact on weight loss."}
{"query_id": "1161", "query_text": "The DEXI promoter region is bound by multiple transcription factors in a murine haematopoietic progenitor cell line.", "negative": "Myelin sheaths play a role in action potential propagation.", "negatives": ["Myelin sheaths play a role in action potential propagation.", "70% of burn patients are admitted for hospitalization and further treatment after appearing at hospital emergency wards or outpatient clinics.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have shorter lifetime exposure to estrogen due to a decreased reproductive period.", "Normal granulomas form in the presence of TNF in Zebrafish.", "TNFAIP3 is a tumor enhancer in glioblastoma.", "Helminths interfere with immune system control of coinfections by microbial pathogens 16.", "Intake of folic acid (FA) and vitamin B6 (VB6) reduces levels of homocysteine.", "Dexamethasone increases risk of postoperative bleeding.", "The first MBT repeat of the four malignant brain tumor (4MBT) domain of Drosophila's Sfmbt and of the orthologous mammalian L3MBTL2 is required for the interaction with the spacer region of Drosophila's Pleiohomeotic (Pho) or its human ortholog YY1.", "Omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegetarians."], "hard_negatives": ["The DEXI promoter region is bound by multiple transcription factors in a murine haematopoietic progenitor cell line.", "TNFAIP3 is a glioblastoma tumor suppressor.", "TNFAIP3 is a glioblastoma tumor enhancer.", "KRT17 modulates the expression of the transcriptional regulator AIRE in diseased epithelia.", "TNFAIP3 is a tumor enhancer in glioblastoma.", "miRNAs regulate a unique suite of mRNAs to maintain homeostasis in cells.", "MUC1-C activates the NF-\u03baB p65 signaling pathway by interacting with I\u03baB kinase \u00df.", "BiP is a general endoplasmic reticulum stress marker.", "Genes regulated by Esrrb transcription factor are sensitive to Mbd3 function.", "Glioblastoma multiforme (GBM) is characterized by extensive invasion, rapid growth, necrosis, and angiogenesis."], "hard_negative": "The DEXI promoter region is bound by multiple transcription factors in a murine haematopoietic progenitor cell line."}
{"query_id": "1162", "query_text": "The DdrB protein from Deinococcus radiodurans functions as a pentamer.", "negative": "B3-Galectin increases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR.", "negatives": ["B3-Galectin increases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR.", "The microtubule-dependent delivery and secretion of matrix metalloproteases (MMPs) is partially responsible for the disassembly of adhesion sites.", "DMS3 protein enables Pol V transcription in vivo.", "A breast cancer patient's capacity to metabolize tamoxifen influences treatment outcome.", "Deltex has no known interactions with eIF3f.", "Lamins are found within the inner layer of the mitochondrial membrane of all cells.", "Aged patients are less susceptible to ischaemia/reperfusion injury.", "Tuberculosis-induced granulomas express different immune system protein signatures than the surrounding tissue.", "Deleting Raptor increases G-CSF levels.", "Increased flux of microbial products provokes immune responses."], "hard_negatives": ["The DdrB protein from Deinococcus radiodurans functions as a pentamer.", "Gpr124 suppresses BBB breakdown in mouse models of ischemic stroke.", "Gpr124 increases BBB breakdown in mouse models of ischemic stroke.", "Transcription factor EB induces transcription of pro-inflammatory cytokines in macrophages infected with Staphylococcus aureus.", "Broadly HIV-1 Neutralizing Antibodies (bnAb) 10EB have no affinity for phospholipids.", "R2D2 stops miRNA production by increasing the selectivity of Dcr2 for long dsRNA.", "Toll-like receptor (TLR) signaling is involved in the pathogenesis of human MDS.", "The PPR MDA5 has twenty N-terminal CARD domains.", "The PRR MDA5 has a C-terminal domain.", "Reduction of purity of cytoplasmic membranes isolated from overexpressors is indicated by stronger spots for OmpA in 2D BN-PAGE gels."], "hard_negative": "The DdrB protein from Deinococcus radiodurans functions as a pentamer."}
{"query_id": "1164", "query_text": "The G34R/V mutation creates a hypomethylated phenotype at the H3K36 histone.", "negative": "BLM gene encodes RecQ-class DNA helicase.", "negatives": ["BLM gene encodes RecQ-class DNA helicase.", "Tonic signaling from the scFv prevents constitutive stimulation.", "Integrated care is ineffective at tackling multiple comorbidities.", "Antimicrobial agents are less effective due to the pressure of antimicrobial usage.", "A mutation in HNF4A leads to an increased risk of developing diabetes by the age of 14 years.", "Low expression of miR7a does not repress target genes or exert a biological function in ovaries.", "A diminished ovarian reserve does not solely indicate infertility in an a priori non-infertile population.", "Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission.", "Adult tissue-resident macrophages stem from the embryonal yolk sac and fetal liver.", "VgrG (Tssl) protein punctures membranes by forming a spike at the tip of the tube apparatus."], "hard_negatives": ["The G34R/V mutation creates a hypomethylated phenotype at the H3K36 histone.", "The G34R/V mutation does not create a hypomethylated phenotype at the H3K36 histone.", "H4 G94P proteins induce degradation of free histones via Rad53-dependent mechanisms.", "H4 G94P proteins induce chromatin assembly, which increases free histones.", "H4 G94P proteins suppress degradation of free histones via Rad53-dependent mechanisms.", "H4 G94P proteins inhibit chromatin assembly, which decreases free histones.", "The minor G allele of FOXO3 is related to less severe symptoms of Crohn's Disease.", "HNF4A mutations are associated with macrosomia in infancy.", "The minor G allele of FOXO3 up-regulates IL-10.", "Mutations in G-Beta protein GNB1 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway."], "hard_negative": "The G34R/V mutation creates a hypomethylated phenotype at the H3K36 histone."}
{"query_id": "1165", "query_text": "The G34R/V mutation does not create a hypomethylated phenotype at the H3K36 histone.", "negative": "Patients with microcytosis and higher erythrocyte count were more resistant to severe malarial anaemia when infected with Plasmodium falciparum.", "negatives": ["Patients with microcytosis and higher erythrocyte count were more resistant to severe malarial anaemia when infected with Plasmodium falciparum.", "Chenodeoxycholic acid treatment increases brown adipose tissue activity.", "\u03b21/Ketel is able to bind microtubules.", "H4 G94P proteins induce chromatin assembly, which increases free histones.", "miRNAs enforce homeostasis by suppressing low-level ''leaky'' transcription.", "Medications to treat obesity have unwanted side effects.", "Mice defective for deoxyribonucleic acid (DNA) polymerase m (polm) fail to reveal increased sensitivity to ionizing radiation (IR).", "Cancer-associated fibroblasts (CAFs) have no known interaction with cancer cells in the formation and activation of CAFs.", "r-protein chaperones are found in complexes with their r-protein binding partners.", "Destination container port throughput(CPT) is negatively related to dengue virus (DENV-1) diffusion in air traffic shipments."], "hard_negatives": ["The G34R/V mutation does not create a hypomethylated phenotype at the H3K36 histone.", "The G34R/V mutation creates a hypomethylated phenotype at the H3K36 histone.", "H4 G94P proteins induce degradation of free histones via Rad53-dependent mechanisms.", "H4 G94P proteins induce chromatin assembly, which increases free histones.", "H4 G94P proteins suppress degradation of free histones via Rad53-dependent mechanisms.", "H4 G94P proteins inhibit chromatin assembly, which decreases free histones.", "The minor G allele of FOXO3 is related to less severe symptoms of Crohn's Disease.", "HNF4A mutations are associated with macrosomia in infancy.", "Mutations in G-Beta protein GNB1 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.", "The minor G allele of FOXO3 up-regulates IL-10."], "hard_negative": "The G34R/V mutation does not create a hypomethylated phenotype at the H3K36 histone."}
{"query_id": "1166", "query_text": "The H2A-H2B eviction defect is compensated for by other histone chaperone(s).", "negative": "Helicobacter pylori-induced aberrant NF-kB-dependent expression of activation-induced cytidine deaminase contributes to the mutagenesis of host DNA.", "negatives": ["Helicobacter pylori-induced aberrant NF-kB-dependent expression of activation-induced cytidine deaminase contributes to the mutagenesis of host DNA.", "Insulin decreases risk of severe kidney failure.", "Microcin J25 inhibits nucleoside triphosphate (NTP) binding.", "50% of patients exposed to radiation have activated markers of mesenchymal stem cells.", "61% of colorectal cancer patients are diagnosed with regional or distant metastases.", "Integrated care is successful at tackling multiple comorbidities.", "Ethanol stress increases the expression of SRL in bacteria.", "Bacteriophagaes MS2 and Q\u03b2 are members of the Leviviridae.", "Inhibiting glucose-6-phospate dehydrogenase improves lipogenesis by deactivating LKB1-AMPK signaling.", "Mice defective for deoxyribonucleic acid (DNA) polymerase I (polI) fail to reveal increased sensitivity to ionizing radiation (IR)."], "hard_negatives": ["The H2A-H2B eviction defect is compensated for by other histone chaperone(s).", "FACT and other histone chaperone(s) compensate for Histone 2A (H2A)-histone 2B (H2B) dimer eviction during the histone exchange process.", "Replacement of histone H2A with H2A.Z accelerates gene activation in yeasts by destabilizing +1 nucleosomes.", "H4 G94P proteins induce degradation of free histones via Rad53-dependent mechanisms.", "H4 G94P proteins suppress degradation of free histones via Rad53-dependent mechanisms.", "The G34R/V mutation does not create a hypomethylated phenotype at the H3K36 histone.", "The G34R/V mutation creates a hypomethylated phenotype at the H3K36 histone.", "H4 G94P proteins induce chromatin assembly, which increases free histones.", "H4 G94P proteins inhibit chromatin assembly, which decreases free histones.", "HNF4A mutations are associated with macrosomia in infancy."], "hard_negative": "The H2A-H2B eviction defect is compensated for by other histone chaperone(s)."}
{"query_id": "1168", "query_text": "The HSV-2 infection is typically asymptomatic.", "negative": "Active Ly49Q prevents neutrophil polarization.", "negatives": ["Active Ly49Q prevents neutrophil polarization.", "Lack of FGF21 in mice slows the rate of atherosclerotic plaque formation.", "Depletion of nitric oxide is responsible for vasospasm.", "Cancer-associated fibroblasts (CAFs) have no known interaction with cancer cells in the formation and activation of CAFs.", "Systemic immunosuppressive (IS) therapy increases the chance of cancer mortality in patients with inflammatory eye disease (IED)", "Chlamydia trachomatis is most prevalent in the UK among sexually-experienced individuals aged 16 to 24.", "Patients in stable partnerships progress from HIV to death at the same rate as patients not in partnerships.", "Increased LDL receptors plays a role in the reduction of plasma Lp(a).", "Propriospinal interneurons that play a role in the plastic reorganization of spinal circuits are integral for recovery from spinal cord injury.", "Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection increases dissemination of Salmonella Typhimurium from the gut."], "hard_negatives": ["The HSV-2 infection is typically asymptomatic.", "A low percentage of hematopoietic progenitor cells are susceptible to HIV-1 infection ex vivo.", "Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection increases dissemination of Salmonella Typhimurium from the gut.", "Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection decreases dissemination of Salmonella Typhimurium from the gut.", "The latent infection of myeloid cells with human cytomegalovirus induces a number of changes in gene expression.", "The composition of myosin-II isoform switches from the A isoform to the B isoform during hematopoietic differentiation.", "Approximately 250,000 people are infected with human T-cell lymphotropic virus type 1 in the United Kingdom.", "Exhaustion of B cells contributes to poor Ab response in HIV-infected individuals.", "Toll-like receptor (TLR) signaling is involved in the pathogenesis of human MDS.", "Continued HHV-8 transmission among MSM in San Francisco may be explained by urogenital contact."], "hard_negative": "The HSV-2 infection is typically asymptomatic."}
{"query_id": "1169", "query_text": "The M2-phenotype in brown adipose tissue macrophages increases brown adipose tissue thermogenic activity.", "negative": "Lack of FGF21 in mice increases life expectancy.", "negatives": ["Lack of FGF21 in mice increases life expectancy.", "Cyclin A2 destruction is necessary to switch from unstable to stable kt-mt attachments in mitosis.", "R2D2 stops miRNA production by increasing the selectivity of Dcr2 for long dsRNA.", "Varying expression levels of EBI2 affect the positioning and migration of B cells.", "Enhanced early production of inflammatory chemokines damages viral control in the lung.", "Sequence conservation in gene regulatory regions between species is a high-accuracy predictor of conserved functionality.", "TNFAIP3 is a tumor enhancer in glioblastoma.", "Rapid phosphotransfer rates are correlated with histidine kinase regulator specificity.", "Lamins are found within the inner layer of the mitochondrial membrane of all cells.", "A deficiency of folate increases blood levels of homocysteine."], "hard_negatives": ["The M2-phenotype in brown adipose tissue macrophages increases brown adipose tissue thermogenic activity.", "An M2-like phenotype in brown adipose tissue macrophages is quickly induced by cold exposure.", "The morphology change from large white adipocytes to small brown adipocytes is a sign of increased energy expenditure potential in white adipose tissue.", "The morphology change from large white adipocytes to small brown adipocytes is a sign of decreased energy expenditure potential in white adipose tissue.", "Chenodeoxycholic acid treatment increases brown adipose tissue activity.", "Chenodeoxycholic acid treatment decreases brown adipose tissue activity.", "Ca2+ cycling controls whole-body energy homeostasis in beige fat.", "Increased lipolysis leads to higher P38 phosphorylation in adipose tissue.", "Reduced levels of lipolysis leads to higher P38 phosphorylation in adipose tissue.", "aPKCz causes tumour suppression by affecting glutamine metabolism."], "hard_negative": "The M2-phenotype in brown adipose tissue macrophages increases brown adipose tissue thermogenic activity."}
{"query_id": "1170", "query_text": "The NF-\u03baB essential modulator gene induces intestinal inflammation by promoting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death.", "negative": "Mutations in RIM1 decrease levels of IME1 RNA.", "negatives": ["Mutations in RIM1 decrease levels of IME1 RNA.", "Converting apoE4 to apoE3 by gene editing worsens the pathology associated with apoE4 in human iPSCderived neurons.", "Physical activity level has no association with the difference in maximal oxygen consumption between black and white youth.", "Patients in stable partnerships progress from HIV to death at the same rate as patients not in partnerships.", "JMJD6 catalyzes the hydroxylation of C-terminal lysine and supresses transcriptional activity.", "1 in 5 million in UK have abnormal PrP positivity.", "The DEXI promoter region is bound by multiple transcription factors in a murine haematopoietic progenitor cell line.", "ScPif1p has reduced binding ability to G-rich ssDNA compared to non-G-rich ssDNA.", "Chlamydia trachomatis is most prevalent in the UK among individuals in their 50s and 60s.", "Increased purity of cytoplasmic membranes isolated from overexpressors is indicated by stronger spots for OmpF in 2D BN-PAGE gels."], "hard_negatives": ["The NF-\u03baB essential modulator gene induces intestinal inflammation by promoting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death.", "The NF-\u03baB essential modulator gene prevents intestinal inflammation by inhibiting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death.", "MUC1-C activates the NF-\u03baB p65 signaling pathway by interacting with I\u03baB kinase \u00df.", "Ribosome-inactivating protein-2 (RIP-2) interacts with the p75 NTR death domain", "ITAM phosphorylation allows for the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).", "p16INK4A degradation is  linked to an abnormal wound response caused by the microinvasive step of advanced Oral Potentially Malignant Lesions (OPMLs).", "Certain immunomodulator-human dialyzable leukocyte extract (hDLE) peptides are recognized by toll-like receptors (TLRs) on macrophages and dendritic cells.", "AMP-activated protein kinase (AMPK) activation reduces inflammation-related fibrosis in the lungs.", "The RANK-RANK-Ligand (RANKL) pathway is involved in the development of Aire-expressing medullary thymic epithelial cells (mTECs).", "Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes fibrosis."], "hard_negative": "The NF-\u03baB essential modulator gene induces intestinal inflammation by promoting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death."}
{"query_id": "1171", "query_text": "The NF-\u03baB essential modulator gene prevents intestinal inflammation by inhibiting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death.", "negative": "Cytochrome c is transferred from cytosol to the mitochondrial intermembrane space during apoptosis.", "negatives": ["Cytochrome c is transferred from cytosol to the mitochondrial intermembrane space during apoptosis.", "Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 inhibit West Nile virus replication in cortical neurons.", "Albendazole is used to treat soil-transmitted helminths.", "Mutations in G-Beta protein GNB1 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.", "Activation of PPM1D enhances p53 function.", "Medications to treat obesity are highly effective.", "Sympathetic nerve activity is reduced throughout normal pregnancy.", "Bone marrow cells don't contribute to adult macrophage compartments.", "LRBA prevents CTLA - 4 recycling.", "Ly6C hi monocytes have a higher inflammatory capacity than Ly6C lo monocytes."], "hard_negatives": ["The NF-\u03baB essential modulator gene induces intestinal inflammation by promoting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death.", "The NF-\u03baB essential modulator gene prevents intestinal inflammation by inhibiting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death.", "MUC1-C activates the NF-\u03baB p65 signaling pathway by interacting with I\u03baB kinase \u00df.", "Ribosome-inactivating protein-2 (RIP-2) interacts with the p75 NTR death domain", "ITAM phosphorylation allows for the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).", "p16INK4A degradation is  linked to an abnormal wound response caused by the microinvasive step of advanced Oral Potentially Malignant Lesions (OPMLs).", "Certain immunomodulator-human dialyzable leukocyte extract (hDLE) peptides are recognized by toll-like receptors (TLRs) on macrophages and dendritic cells.", "AMP-activated protein kinase (AMPK) activation reduces inflammation-related fibrosis in the lungs.", "Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes fibrosis.", "Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes epithelial damage."], "hard_negative": "The NF-\u03baB essential modulator gene induces intestinal inflammation by promoting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death."}
{"query_id": "1173", "query_text": "The PDPN gene deactivates the C-type lectin receptor (CLEC-2).", "negative": "The US health care system can save up to $5 billion if 7% of patients waiting for kidney transplants participate in the optimized national kidney paired donation program.", "negatives": ["The US health care system can save up to $5 billion if 7% of patients waiting for kidney transplants participate in the optimized national kidney paired donation program.", "MafA phosphorylation decreases its ubiquitination.", "PrimPol generates short DNA replication intermediates on the leading strand during DNA replication.", "In transgenic mice harboring green florescent protein under the control of the Sox2 promoter, more than 50 percent of the cells with green florescent colocalize with cell proliferation markers.", "Adult tissue-resident macrophages stem from the embryonal yolk sac and fetal liver.", "Asymptomatic visual impairment screening in elderly populations leads to improved vision.", "1 in 5 million in UK have abnormal PrP positivity.", "Egr2 regulates the homeostasis of B and T cells.", "Sudden death can occur in patients with complex ventricular arrhythmias.", "JMJD6 slows the hydroxylation of C-terminal lysine"], "hard_negatives": ["The PDPN gene deactivates the C-type lectin receptor (CLEC-2).", "The C-type lectin receptor (CLEC-2) rearranges the actin cytoskeleton in dendritic cells to promote efficient motility along stromal surfaces.", "Activated Cdk5 phosphorylates the ATM protein in response to DNA damage.", "BCL-2 activation antagonizes the apoptotic effects of c-Myc.", "Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes fibrosis.", "ITAM phosphorylation allows for the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).", "RTEL1 interacts with TRF2 through a C4C4 motif", "BCL-2 promotes the apoptotic effects of c-Myc.", "CCL19 is a ligand for CCR7.", "Activated Cdk5 regulates DNA damage-induced neuronal death."], "hard_negative": "The PDPN gene deactivates the C-type lectin receptor (CLEC-2)."}
{"query_id": "1174", "query_text": "The PPR MDA5 has twenty N-terminal CARD domains.", "negative": "Hypothalamic glutamate neurotransmission is unrelated to energy balance.", "negatives": ["Hypothalamic glutamate neurotransmission is unrelated to energy balance.", "Replacement of OCT4 and SOX2 genes with GATA3 is not capable of reprogramming human cells.", "There is a relation between Erythromycin use and hypertrophic pyloric stenosis.", "The risk of female prisoners harming themselves is ten times that of male prisoners.", "Citrullinated proteins externalized in neutrophil extracellular traps act indirectly to disrupt the inflammatory cycle.", "mcm 5 s 2 U is required for proper decoding of NNR codons in eukaryotes.", "Medications to treat obesity have unwanted side effects.", "For every 1,000 children with cerebral palsy, more than 300 of them are premature or underweight at birth.", "Piezo1 channels are sensors for cell migration in epithelial cells.", "Mice lacking Sirt1 in Sf1-expressing neurons have increased susceptibility to diet-induced obesity and insulin resistance."], "hard_negatives": ["The PPR MDA5 has twenty N-terminal CARD domains.", "The PRR MDA5 has a C-terminal domain.", "The artifactual C-terminal helix swapping in the StART domain is observed in the Ups1-Mdm35 heterodimer of the StARkin superfamily.", "Toll-like receptor (TLR) signaling is involved in the pathogenesis of human MDS.", "R2D2 stops miRNA production by increasing the selectivity of Dcr2 for long dsRNA.", "Bcp1 is a chaperone for Rpl23.", "Emodin forms hydrogen bonds with residues involved in PGAM1 substrate binding.", "Dscam1 acts as a hypervariable pattern-recognition receptor for the immune system.", "BLM gene encodes RecQ-class DNA helicase.", "Commelina yellow mottle virus (ComYMV) has three typical badnavirus ORFs, capable of encoding proteins 23, 15, and 216 kD."], "hard_negative": "The PPR MDA5 has twenty N-terminal CARD domains."}
{"query_id": "1176", "query_text": "The PRDM1 gene is a key determinant of primordial germ cells.", "negative": "DRD1 proteins enable Pol V transcription in vivo.", "negatives": ["DRD1 proteins enable Pol V transcription in vivo.", "Recognition of start codons depends on the translation initiation factor IF3.", "A deficiency of vitamin B6 decreases blood levels of homocysteine.", "Active caspase-11 protein promotes pyroptosis.", "Inhibiting glucose-6-phospate dehydrogenase improves lipogenesis by deactivating LKB1-AMPK signaling.", "Active H. pylori urease has a polymeric structure consisting of five distinct subunits.", "1-1% of colorectal cancer patients are diagnosed with regional or distant metastases.", "Increased microtubule acetylation repairs interference of axonal transport caused by LRRK2 Roc-COR domain mutations.", "There was an estimated 30 million cases of pneumonia in young children worldwide in 2010.", "0-dimensional biomaterials lack inductive properties."], "hard_negatives": ["The PRDM1 gene is a key determinant of primordial germ cells.", "The PRDM1 gene, when combined with the PRDM14 gene, plays an important role during primordial germ cell specification.", "The myocardial cell lineage originally develops from cardiac progenitors of exclusively endodermal origin.", "Rhythmic expression of Cry1 translates directly into a circadian regulation of cAMP signaling in hepatic glucose metabolism.", "The Snf1 complex regulates carbon and energy metabolism in baker's yeast (Saccharomyces cerevisiae).", "Human embryonic stem cells have the capacity to give rise to differentiated progeny representative of all three embryonic germ layers.", "The proliferative capacity of progenitors is regulated cell-autonomously.", "Activation of the Rac1 homolog CED-10 kills viable cells in SRGP-1 mutant Caenorhabditis elegans.", "Binding of p53 to enhancer regions (p53BERs) regulates the activity of p53 transcription and cell cycle arrest through the production of p53-dependent eRNAs.", "Rhythmic expression of Cry1 translates directly into a circadian regulation of cAMP signaling in gluconeogenesis."], "hard_negative": "The PRDM1 gene is a key determinant of primordial germ cells."}
{"query_id": "1177", "query_text": "The PRDM1 gene, when combined with the PRDM14 gene, plays an important role during primordial germ cell specification.", "negative": "Bariatric surgery leads to negative outcomes in mental health.", "negatives": ["Bariatric surgery leads to negative outcomes in mental health.", "Metastatic colorectal cancer treated with a single agent fluoropyrimidines resulted in similar efficacy and better quality of life when compared with oxaliplatin-based chemotherapy in elderly patients.", "Polymeal nutrition increases cardiovascular mortality.", "Asymptomatic visual impairment screening in elderly populations leads to improved vision.", "Fibroblast growth factor 21 protects against atherosclerosis by modulating adiponectin and SREBP2 levels.", "Glycan adaptation is rarely observed in the B-cell repertoire.", "Mutant mice lacking SVCT2 have severely reduced ascorbic acid levels in both brain and adrenals.", "Androgenetic haploid mouse embryonic stem cells (ESCs) can be derived and genetically manipulated in vitro.", "LDL cholesterol has a causal role in the development of cardiovascular disease.", "7-day-old adult Caenorhabditis elegans exhibit approximately 5% of the learning capacity seen in 1-day old adults."], "hard_negatives": ["The PRDM1 gene, when combined with the PRDM14 gene, plays an important role during primordial germ cell specification.", "The PRDM1 gene is a key determinant of primordial germ cells.", "Rhythmic expression of Cry1 translates directly into a circadian regulation of cAMP signaling in gluconeogenesis.", "Rhythmic expression of Cry1 translates directly into a circadian regulation of cAMP signaling in hepatic glucose metabolism.", "Activation of PPM1D enhances p53 function.", "The Snf1 complex regulates carbon and energy metabolism in baker's yeast (Saccharomyces cerevisiae).", "Binding of p53 to enhancer regions (p53BERs) regulates the activity of p53 transcription and cell cycle arrest through the production of p53-dependent eRNAs.", "Human embryonic stem cells have the capacity to give rise to differentiated progeny representative of all three embryonic germ layers.", "MeCP2 influences the synaptic maturation of neurons.", "The myocardial cell lineage originally develops from cardiac progenitors of exclusively endodermal origin."], "hard_negative": "The PRDM1 gene, when combined with the PRDM14 gene, plays an important role during primordial germ cell specification."}
{"query_id": "1178", "query_text": "The PRR MDA5 has a C-terminal domain.", "negative": "Assessing treatment adherence is more beneficial to clinical practice than measuring routine outcomes.", "negatives": ["Assessing treatment adherence is more beneficial to clinical practice than measuring routine outcomes.", "Immune responses in immune cells are geographically segregated.", "Removal of H3K9me3 improves reprogramming efficiency in human somatic cell nuclear transfer experiments.", "Ly6C hi monocytes have a higher inflammatory capacity than Ly6C lo monocytes.", "Asymptomatic visual impairment screening in elderly populations leads to improved vision.", "Acute ablation of KRAS causes severe growth impairment.", "The recruitment of Wdr5 to its target loci depends on Kat8.", "Rhythmic expression of Cry1 translates directly into a circadian regulation of cAMP signaling in gluconeogenesis.", "7-day-old adult Caenorhabditis elegans exhibit approximately 75% of the learning capacity seen in 1-day old adults.", "Peroxynitrite is required for induction of T cell tolerance."], "hard_negatives": ["The PRR MDA5 has a C-terminal domain.", "The PPR MDA5 has twenty N-terminal CARD domains.", "Toll-like receptor (TLR) signaling is involved in the pathogenesis of human MDS.", "The artifactual C-terminal helix swapping in the StART domain is observed in the Ups1-Mdm35 heterodimer of the StARkin superfamily.", "R2D2 stops miRNA production by increasing the selectivity of Dcr2 for long dsRNA.", "Dscam1 acts as a hypervariable pattern-recognition receptor for the immune system.", "CCL19 is a ligand for CCR7.", "Deltex has no known interactions with eIF3f.", "BLM gene encodes RecQ-class DNA helicase.", "TNFAIP3 is a glioblastoma tumor suppressor."], "hard_negative": "The PRR MDA5 has a C-terminal domain."}
{"query_id": "1181", "query_text": "The RANK-RANK-Ligand (RANKL) pathway is involved in the development of Aire-expressing medullary thymic epithelial cells (mTECs).", "negative": "DUSP4 decreases apoptosis.", "negatives": ["DUSP4 decreases apoptosis.", "B3-Galectin increases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR.", "Primary cervical cytology screening with HPV detection has higher longitudinal sensitivity to detect severe cervical intraepithelial neoplasia than conventional cytology.", "The most prevalent adverse events to Semaglutide are gastrointestinal.", "Walking in traffic areas in London did not improve lung function in elderly adults.", "The removal of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells.", "There is no increased risk of hypospadias with clomiphene.", "BRCA 1 mutation carriers' risk of breast and ovarian cancer depends on where the mutation is located.", "Ambulatory blood pressure monitoring is inaccurate at diagnosing hypertension.", "The mean suicide rate in women is lower after miscarriage than live birth."], "hard_negatives": ["The RANK-RANK-Ligand (RANKL) pathway is involved in the development of Aire-expressing medullary thymic epithelial cells (mTECs).", "RANK-RANKL pathway signalling is linked to development of Aire-expressing medullary thymic epithelial cells.", "RANK-RANKL pathway signalling has no known association with development of Aire-expressing medullary thymic epithelial cells.", "KRT17 modulates the expression of the transcriptional regulator AIRE in diseased epithelia.", "AMP-activated protein kinase (AMPK) activation reduces inflammation-related fibrosis in the lungs.", "The NF-\u03baB essential modulator gene induces intestinal inflammation by promoting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death.", "The NF-\u03baB essential modulator gene prevents intestinal inflammation by inhibiting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death.", "ITAM phosphorylation allows for the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).", "ER-localized phosphatase Sac1 processes PI4P through coordination with OSBP and the endosome-localized protein sorting nexin 2.", "The C-type lectin receptor (CLEC-2) rearranges the actin cytoskeleton in dendritic cells to promote efficient motility along stromal surfaces."], "hard_negative": "The RANK-RANK-Ligand (RANKL) pathway is involved in the development of Aire-expressing medullary thymic epithelial cells (mTECs)."}
{"query_id": "1182", "query_text": "The Snf1 complex regulates carbon and energy metabolism in baker's yeast (Saccharomyces cerevisiae).", "negative": "Blocking the interaction between TDP-43 and respiratory complex I proteins ND3 and ND6 prevents TDP-43-induced neuronal loss.", "negatives": ["Blocking the interaction between TDP-43 and respiratory complex I proteins ND3 and ND6 prevents TDP-43-induced neuronal loss.", "ERAP1 SNPs are epistatic to HLA alleles for ankylosing spondylitis.", "Induction of urokinase receptor signaling in podocytes causes foot process effacement and proteinuria.", "Omnivores produce less trimethylamine N-oxide from dietary I-carnitine than vegans.", "A single nucleotide variant the gene DGKK is strongly associated with increased risk of hypospadias.", "Early patent ductus ateriosus (PDA) screening decreases in-hospital mortality.", "Addition of BMP4, activin A, CHIR99021, and SU504 to reprogramming fibroblasts generates, expands and maintains cardiovascular progenitor cells (CPCs)", "Antidepressants increase the severity of migraines.", "7-day-old adult Caenorhabditis elegans exhibit approximately 5% of the learning capacity seen in 1-day old adults.", "ALDH1 expression is associated with poorer prognosis for breast cancer primary tumors."], "hard_negatives": ["The Snf1 complex regulates carbon and energy metabolism in baker's yeast (Saccharomyces cerevisiae).", "Mitochondria play a major role in energy production.", "Ethanol stress increases the expression of IBP in bacteria.", "Oxidative phosphorylation is one of the primary glycometabolic pathways in cells.", "Rhythmic expression of Cry1 translates directly into a circadian regulation of cAMP signaling in hepatic glucose metabolism.", "MUC1-C activates the NF-\u03baB p65 signaling pathway by interacting with I\u03baB kinase \u00df.", "Replacement of histone H2A with H2A.Z accelerates gene activation in yeasts by destabilizing +1 nucleosomes.", "Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 encourage West Nile virus replication in cortical neurons.", "miRNAs regulate a unique suite of mRNAs to maintain homeostasis in cells.", "miR-142-5P is a temperature-sensitive microRNA (miRNA)."], "hard_negative": "The Snf1 complex regulates carbon and energy metabolism in baker's yeast (Saccharomyces cerevisiae)."}
{"query_id": "1183", "query_text": "The TRaF1/C5 rs10818488 allele polymorphism regulates the neighboring C5 gene.", "negative": "Adult tissue-resident macrophages are seeded before birth.", "negatives": ["Adult tissue-resident macrophages are seeded before birth.", "BLM gene encodes RecQ-class DNA helicase.", "Cost effectiveness evaluations based on cRCT data lack external validity.", "Cognitive behavioral therapy is an ineffective treatment for insomnia", "Formation of N-terminal pyroglutamate by glutamine cyclase (GC) competes with NTAQ1 for Nt-Gln substrates.", "Tonic signaling from the scFv induces constitutive stimulation.", "Deletion of ATM and Rad3 related protein leads to acute tissue loss.", "Exercise increases cancer mortality rates among Chinese citizens.", "The proliferative capacity of progenitors is regulated cell-autonomously.", "CRP is positively correlated with postoperative mortality following Coronary Artery Bypass Graft (CABG) surgery."], "hard_negatives": ["The TRaF1/C5 rs10818488 allele polymorphism regulates the neighboring C5 gene.", "RTEL1 interacts with TRF2 through a C4C4 motif", "Bcp1 is a chaperone for Rpl23.", "The PPR MDA5 has twenty N-terminal CARD domains.", "mcm 5 s 2 U is required for proper decoding of NNR codons in eukaryotes.", "The recruitment of Wdr5 to its target loci depends on Kat8.", "The predominant localization of Linc00173 is in mononuclear macrophage nuclei.", "The PRR MDA5 has a C-terminal domain.", "The PDPN gene deactivates the C-type lectin receptor (CLEC-2).", "CCL19 is a ligand for CCR7."], "hard_negative": "The TRaF1/C5 rs10818488 allele polymorphism regulates the neighboring C5 gene."}
{"query_id": "1184", "query_text": "The US health care system can save up to $5 billion if 7% of patients waiting for kidney transplants participate in the optimized national kidney paired donation program.", "negative": "HSCT-T dosage may not be diagnostic if the onset of symptoms occurs less than 3 hours before AMI.", "negatives": ["HSCT-T dosage may not be diagnostic if the onset of symptoms occurs less than 3 hours before AMI.", "10% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.", "miR-142-5P is a known regulator of raised body temperature.", "Risedronate increases risk of vertebral and non-vertebral fractures.", "Ethanol stress increases the expression of SRL in bacteria.", "Differentiation of progenitor cells to myeloid cells is skewed when insulin signaling is suppressed.", "Tumor development occurs in conjunction with suppression of pro-inflammatory cytokines.", "T cell receptor /CD3 microdomains are required to induce the immunologic synapse.", "Glial calcium waves influence seizures.", "Early patent ductus ateriosus (PDA) screening decreases in-hospital mortality."], "hard_negatives": ["The US health care system can save up to $5 billion if 7% of patients waiting for kidney transplants participate in the optimized national kidney paired donation program.", "32% of liver transplantation programs required patients to discontinue methadone treatment in 2001.", "Angiotensin converting enzyme inhibitors are associated with decreased risk for functional renal insufficiency.", "40mg/day dosage of folic acid and 2mg/day dosage of vitamin B12 does not affect chronic kidney disease (CKD) progression.", "Ten percent (10%) of kidney cancers in the UK are attributable to excess weight.", "Insulin decreases risk of severe kidney failure.", "Risk of cardiovascular events can be cut by a third by using antihypertensive drug therapy among hemodialysis patients.", "The effect of Lipopolysaccharides on kidney barrier function is dependent on inflammation levels.", "CRP is positively correlated with postoperative mortality following Coronary Artery Bypass Graft (CABG) surgery.", "Bone Marrow (BM) transplantation is used to treat acute myeloid leukemia (AML)"], "hard_negative": "The US health care system can save up to $5 billion if 7% of patients waiting for kidney transplants participate in the optimized national kidney paired donation program."}
{"query_id": "1186", "query_text": "The World Health Organization's (WHO) data collection process is biased downward by unequal selection of larger outbreaks.", "negative": "Bcp1 is a chaperone for Rpl23.", "negatives": ["Bcp1 is a chaperone for Rpl23.", "Upon developing tyrosine-kinase inhibitor resistance, new mutations in epidermal growth factor receptors emerge and cause treatment failure.", "Rising temperatures caused by global warming lowers the risk of dengue fever transmission.", "The appearance of brown-like or beige cells primarily occurs in visceral fat, not subcutaneous fat.", "PCSK9 inhibitors decrease plasma Lp(a) levels.", "Stroke patients with prior use of direct oral anticoagulants have a higher risk of in-hospital mortality than stroke patients with prior use of warfarin.", "FACT and other histone chaperone(s) compensate for Histone 2A (H2A)-histone 2B (H2B) dimer eviction during the histone exchange process.", "Deletion of ATM and Rad3 related protein is not predictive of acute tissue loss.", "Polymeal nutrition increases cardiovascular mortality.", "Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 encourage West Nile virus replication in cortical neurons."], "hard_negatives": ["The World Health Organization's (WHO) data collection process is biased downward by unequal selection of larger outbreaks.", "Rising temperatures caused by global warming lowers the risk of dengue fever transmission.", "Rising temperatures caused by global warming increases risk of dengue fever transmission.", "Malaria has a high vectorial capacity.", "Urbanization is an important risk factor related to the transmission of dengue fever.", "Sepsis related mortality has risen from 2009 to 2014.", "Tuberculosis incidence occurs at higher rates in more sparsely populated areas in the UK.", "Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission.", "Epidemiological disease burden from noncommunicable diseases is more prevalent in high economic settings.", "The innate immune response struggles to remove small numbers of parasites."], "hard_negative": "The World Health Organization's (WHO) data collection process is biased downward by unequal selection of larger outbreaks."}
{"query_id": "1188", "query_text": "The ability of activator E2Fs in preventing cell death is limited to terminally differentiated cells.", "negative": "Early patent ductus ateriosus (PDA) screening decreases in-hospital mortality.", "negatives": ["Early patent ductus ateriosus (PDA) screening decreases in-hospital mortality.", "Obesity decreases life quality.", "Active Ly49Q induces neutrophil polarization.", "Clathrin stabilizes the spindle fiber apparatus during mitosis.", "Expression of oncolytic virus antigens as peptides makes relapse more likely.", "Excess gestational weight gain is associated with obesity-related pregnancy outcomes.", "Side effects associated with antidepressants lower risk of myocardial infarction.", "The Snf1 complex regulates carbon and energy metabolism in baker's yeast (Saccharomyces cerevisiae).", "Gastric infection with Helicobacter pylori increases risk of gastric cancer in humans.", "Lack of FGF21 in mice leads to atherosclerotic plaque formation."], "hard_negatives": ["The ability of activator E2Fs in preventing cell death is limited to terminally differentiated cells.", "Differentiated E2f-1, -2, -3 TKO cells in the intestine do not exhibit apoptosis.", "Egr2 regulates the homeostasis of B and T cells.", "Varying expression levels of EBI2 affect the positioning and migration of B cells.", "Mutations in G-Beta protein GNB1 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.", "EGR2 is important to myelination of the peripheral nervous system.", "The Snf1 complex regulates carbon and energy metabolism in baker's yeast (Saccharomyces cerevisiae).", "Osteocytes have an essential role in G-CSF induced HSPC mobilization.", "Egr3 regulates the homeostasis of B and T cells.", "In S. cerevisiae, the absence of RNA surveillance pathways reduces sensitivity to high iron conditions."], "hard_negative": "The ability of activator E2Fs in preventing cell death is limited to terminally differentiated cells."}
{"query_id": "1190", "query_text": "The amount of publicly available DNA data doubles every 10 months.", "negative": "Monoclonal antibody targeting of N-cadherin encourages castration resistance.", "negatives": ["Monoclonal antibody targeting of N-cadherin encourages castration resistance.", "Overexpressing Cnp1 N-tail variants rescues the temperature-sensitive growth defect of scm3-139.", "B3-Galectin decreases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR.", "Rising temperatures caused by global warming increases risk of dengue fever transmission.", "Including pharmacists in rounding teams does not alter the incidence of adverse drug events (ADEs).", "Ethanol stress increases the expression of SRL in bacteria.", "The C-type lectin receptor (CLEC-2) rearranges the actin cytoskeleton in dendritic cells to promote efficient motility along stromal surfaces.", "Medications to treat obesity have unwanted side effects.", "L3MBTL2 binds to H2AK119Ub marked chromatin to form a PRC1 complex.", "IFIT1 speeds viral replication by allowing for the proliferation of mis-capped viral RNAs."], "hard_negatives": ["The amount of publicly available DNA data doubles every 10 months.", "53% of perinatal mortality is due to low birth weight.", "Sepsis related mortality has risen from 2009 to 2014.", "Genes involved in pre-mRNA splicing have a significant impact on genome stability.", "For every 1,000 children with cerebral palsy, more than 300 of them are premature or underweight at birth.", "Low nucleosome occupancy correlates with high methylation levels across species.", "The World Health Organization's (WHO) data collection process is biased downward by unequal selection of larger outbreaks.", "De novo assembly of sequence data has fewer specific contigs than unassembled sequence data.", "De novo assembly of sequence data has shorter contigs than unassembled sequence data.", "Transcription rates in S. cerevisiae range between 7 and 12 kb/min."], "hard_negative": "The amount of publicly available DNA data doubles every 10 months."}
{"query_id": "1193", "query_text": "The appearance of brown-like or beige cells primarily occurs in visceral fat, not subcutaneous fat.", "negative": "Reduced levels of lipolysis leads to higher P38 phosphorylation in adipose tissue.", "negatives": ["Reduced levels of lipolysis leads to higher P38 phosphorylation in adipose tissue.", "Marmosets have a brain region homologous to Broca's area.", "Exercise increases cancer mortality rates among Chinese citizens.", "Bariatric surgery leads to positive outcomes in mental health.", "Men are more susceptible to death due to pneumonia when compared to women.", "In S. cerevisiae, the absence of RNA surveillance pathways causes sensitivity to high iron conditions.", "Vitamin D is an important factor in the relationship between calcium and parathyroid hormone.", "Post-transcriptional handling of mitochondrial transcripts occurs in mitochondrial RNA granules.", "Environmental factors can influence the development of breast cancer.", "Including pharmacists in rounding teams does not alter the incidence of adverse drug events (ADEs)."], "hard_negatives": ["The appearance of brown-like or beige cells primarily occurs in visceral fat, not subcutaneous fat.", "Ca2+ cycling controls whole-body energy homeostasis in beige fat.", "The morphology change from large white adipocytes to small brown adipocytes is a sign of decreased energy expenditure potential in white adipose tissue.", "The morphology change from large white adipocytes to small brown adipocytes is a sign of increased energy expenditure potential in white adipose tissue.", "Myelin sheaths are lipid-rich cellular structures.", "The tissue surrounding the granuloma in an immune cell induces an anti-inflammatory immune response.", "Bone marrow cells don't contribute to adult macrophage compartments.", "Normal granulomas form in the presence of TNF in Zebrafish.", "Normal granulomas form in the absence of TNF in Zebrafish.", "Adult tissue-resident macrophages stem from the embryonal yolk sac and fetal liver."], "hard_negative": "The appearance of brown-like or beige cells primarily occurs in visceral fat, not subcutaneous fat."}
{"query_id": "1195", "query_text": "The artifactual C-terminal helix swapping in the StART domain is observed in the Ups1-Mdm35 heterodimer of the StARkin superfamily.", "negative": "Omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegans.", "negatives": ["Omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegans.", "Aged patients are less susceptible to ischaemia/reperfusion injury.", "A deficiency of vitamin B6 decreases blood levels of homocysteine.", "Ribosomopathies have a high degree of cell and tissue specific pathology.", "Bcp1 is a chaperone for Rpl23.", "RANK-RANKL pathway signalling is linked to development of Aire-expressing medullary thymic epithelial cells.", "The C-type lectin receptor (CLEC-2) rearranges the actin cytoskeleton in dendritic cells to promote efficient motility along stromal surfaces.", "IL-10 production by monocytes inhibits CD4 + T cell response.", "Bariatric surgery reduces colorectal cancer.", "In British Men, haplogroup I increases risk of cardiovascular disease by 50%."], "hard_negatives": ["The artifactual C-terminal helix swapping in the StART domain is observed in the Ups1-Mdm35 heterodimer of the StARkin superfamily.", "The PPR MDA5 has twenty N-terminal CARD domains.", "The PRR MDA5 has a C-terminal domain.", "Emodin forms hydrogen bonds with residues involved in PGAM1 substrate binding.", "R2D2 stops miRNA production by increasing the selectivity of Dcr2 for long dsRNA.", "mcm 5 s 2 U is required for proper decoding of NNR codons in eukaryotes.", "LSD1-positive promoters are associated with RNA polymerase II", "Mutations in RIM1 decrease levels of IME1 RNA.", "Guanine nucleotide dissociation inhibitor (Rho-GDI) interacts with the p75 NTR death domain", "Formation of N-terminal pyroglutamate by glutamine cyclase (GC) competes with NTAQ1 for Nt-Gln substrates."], "hard_negative": "The artifactual C-terminal helix swapping in the StART domain is observed in the Ups1-Mdm35 heterodimer of the StARkin superfamily."}
{"query_id": "1205", "query_text": "The combination of physical examinations with C-reactive protein values do not improve the accuracy of radiographic verified pneumonia predictions.", "negative": "Nuclear transfer from adult human fibroblasts to human oocytes can give rise to blastocysts containing expandable pluripotent cells.", "negatives": ["Nuclear transfer from adult human fibroblasts to human oocytes can give rise to blastocysts containing expandable pluripotent cells.", "Insulin effects appetite via ventral tegmental neurons.", "The most prevalent adverse events to Semaglutide are gastrointestinal.", "Genes involved in pre-mRNA splicing have a significant impact on genome stability.", "Kir7.1 modulates channel activity by the G protein-coupled melanocortin-4 receptor (MC4R) in the paraventricular nucleus of the hypothalamus.", "Pioglitazone use is significantly associated with an increased risk of pancreatic cancer.", "Tirasemtiv has no effect on cardiac muscle.", "Chemical injury represses transglutaminase 2 activity.", "Overexpressing Cnp1 N-tail variants rescues the temperature-sensitive growth defect of scm3-139.", "Tirasemtiv targets fast-twitch muscle."], "hard_negatives": ["The combination of physical examinations with C-reactive protein values do not improve the accuracy of radiographic verified pneumonia predictions.", "Tuberculosis-induced granulomas express different immune system protein signatures than the surrounding tissue.", "Men are more susceptible to death due to pneumonia when compared to women.", "Women are more susceptible to death due to pneumonia when compared to men.", "There was an estimated 30 million cases of pneumonia in young children worldwide in 2010.", "Antiretroviral therapy increases rates of tuberculosis across a broad range of CD4 strata.", "The World Health Organization's (WHO) data collection process is biased downward by unequal selection of larger outbreaks.", "Primary cervical cytology screening with HPV detection has higher longitudinal sensitivity to detect severe cervical intraepithelial neoplasia than conventional cytology.", "Risk of cardiovascular events can be cut by a third by using antihypertensive drug therapy among hemodialysis patients.", "High levels of CRP lead to a higher risk of exacerbations in chronic obstructive pulmonary disease (COPD)."], "hard_negative": "The combination of physical examinations with C-reactive protein values do not improve the accuracy of radiographic verified pneumonia predictions."}
{"query_id": "1206", "query_text": "The composition of myosin-II isoform switches from the A isoform to the B isoform during hematopoietic differentiation.", "negative": "Active Ly49Q induces neutrophil polarization.", "negatives": ["Active Ly49Q induces neutrophil polarization.", "Upregulation of PD1 causes the downmodulation of Satb1.", "Cost effectiveness evaluations based on cRCT data lack external validity.", "Destination container port throughput(CPT) is positively related to dengue virus (DENV-1) diffusion in air traffic shipments.", "The most prevalent adverse events to Semaglutide are cardiovascular.", "Vitamin D deficiency effects birth weight.", "YAP/TAZ is required in intestinal regeneration in mouse models of ulcerative colitis.", "Immune complex triggered cell death leads to extracellular release of nuclear DNA.", "Intra-cerebroventricular infusion of amyloid-\u03b2 oligomers increases expression of fibronectin type-III domain-containing protein 5 mRNA in mice hippocampi.", "PTEN is a regulator for the transcriptional activity of SRF"], "hard_negatives": ["The composition of myosin-II isoform switches from the A isoform to the B isoform during hematopoietic differentiation.", "Varying expression levels of EBI2 affect the positioning and migration of B cells.", "GATA3 regulates cell cycle progression in bone marrow hematopoietic stem cells.", "Active H. pylori urease has a polymeric structure consisting of five distinct subunits.", "The HSV-2 infection is typically asymptomatic.", "B cells go though plasmablast differentiation and antibody production by continuous expression of EBI2.", "GATA3 regulates self-renewal capacity in bone marrow hematopoietic stem cells.", "Egr3 regulates the homeostasis of B and T cells.", "Egr2 regulates the homeostasis of B and T cells.", "Mutations in G-Beta protein GNB1 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway."], "hard_negative": "The composition of myosin-II isoform switches from the A isoform to the B isoform during hematopoietic differentiation."}
{"query_id": "1208", "query_text": "The cytokine receptor which regulates chemotaxis and formation of lymph nodes is involved in production of myeloperoxidase in the left atrium.", "negative": "Chemical injury represses transglutaminase 2 activity.", "negatives": ["Chemical injury represses transglutaminase 2 activity.", "The G34R/V mutation does not create a hypomethylated phenotype at the H3K36 histone.", "CDK6 shows improved binding to loss-of-function variants of p18 INK4C.", "Sympathetic nerve activity is reduced throughout normal pregnancy.", "Diabetes remission occurs less in people treated with conventional therapy than in people treated with laparoscopic adjustable gastric banding surgery.", "Foxk2 regulates autophagy genes in muscle cells and fibroblast cells.", "Incidence of heart failure increased by 10% in women since 1979.", "The recruitment of Wdr5 to its target loci depends on Kat8.", "BiP is a general endoplasmic reticulum stress marker.", "Glial calcium waves influence seizures."], "hard_negatives": ["The cytokine receptor which regulates chemotaxis and formation of lymph nodes is involved in production of myeloperoxidase in the left atrium.", "Osteocytes have an essential role in G-CSF induced HSPC mobilization.", "AMP-activated protein kinase (AMPK) activation reduces inflammation-related fibrosis in the lungs.", "Pro-inflammatory cytokines are up regulated during tumor development.", "Cancer cells can stimulate the accumulation of intra-tumoural myeloid-derived suppressor cells by promoting granulocyte colony stimulating factor production.", "Klf4 is important for proper myeloid cell differentiation.", "Cancer-associated fibroblasts (CAFs) interact with cancer cells to mediate formation and activation of CAFs.", "Increased lipolysis leads to higher P38 phosphorylation in adipose tissue.", "Reduced levels of lipolysis leads to higher P38 phosphorylation in adipose tissue.", "Tumor development occurs in conjunction with upregulation of pro-inflammatory cytokines."], "hard_negative": "The cytokine receptor which regulates chemotaxis and formation of lymph nodes is involved in production of myeloperoxidase in the left atrium."}
{"query_id": "1209", "query_text": "The deamination of cytidine to uridine on the minus strand of viral DNA can inactivate the viral genome by inducing G-to-A mutations.", "negative": "Scapular stabilizer exercises are more effective than general exercise therapy in reducing pain and improving function of the shoulder.", "negatives": ["Scapular stabilizer exercises are more effective than general exercise therapy in reducing pain and improving function of the shoulder.", "Deletion of ATM and Rad3 related protein is not predictive of acute tissue loss.", "Reduced responsiveness to interleukin-2 in regulatory T cells is associated with autoimmune diseases such as Type 1 Diabetes.", "IgA plasma cells that are specific for transglutaminase 2 are scarce in the duodenal mucosa of celiac disease patients when the disease is active.", "The combination of physical examinations with C-reactive protein values do not improve the accuracy of radiographic verified pneumonia predictions.", "Tonic signaling from the scFv induces constitutive stimulation.", "Normal granulomas form in the presence of TNF in Zebrafish.", "RA activation of DIF2 and NB4 cells induces hallmarks of transcriptionally active promoters.", "Gpr124 increases BBB breakdown in mouse models of ischemic stroke.", "The PRR MDA5 has a C-terminal domain."], "hard_negatives": ["The deamination of cytidine to uridine on the minus strand of viral DNA can inactivate the viral genome by inducing G-to-A mutations.", "Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 inhibit West Nile virus replication in cortical neurons.", "Immune complex triggered cell death leads to sequestration of oxidized mitochondrial DNA.", "Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 encourage West Nile virus replication in cortical neurons.", "Mutations in G-Beta protein GNB1 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.", "Cytochrome c is transferred from cytosol to the mitochondrial intermembrane space during apoptosis.", "Formation of N-terminal pyroglutamate by glutamine cyclase (GC) competes with NTAQ1 for Nt-Gln substrates.", "Glycan adaptation involves insertion-deletion events.", "ScPif1p has higher binding ability to G-rich ssDNA than to non-G-rich ssDNA.", "ScPif1p has reduced binding ability to G-rich ssDNA compared to non-G-rich ssDNA."], "hard_negative": "The deamination of cytidine to uridine on the minus strand of viral DNA can inactivate the viral genome by inducing G-to-A mutations."}
{"query_id": "1210", "query_text": "The density of cytokine receptor bearing cells affects the distance over which cytokines act.", "negative": "miRNAs enforce homeostasis by suppressing low-level ''leaky'' transcription.", "negatives": ["miRNAs enforce homeostasis by suppressing low-level ''leaky'' transcription.", "Increased microtubule acetylation exacerbates LRRK2 Roc-COR domain mutation induced locomotor deficits.", "p75 NTR - associated cell death executor (NADE) interacts with the p75 NTR death domain", "Combination nicotine replacement therapies with varenicline or bupropion are more effective after 12 weeks of reatment compared to varenicline monotherapy.", "Major vault protein (MVP) leads to more aggressive tumors by regulating the sorting of tumor suppressive miR-193a into extracellular vesicles (EVs).", "Mutations in G-Beta protein GNB1 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.", "Nonhypertensive people who are 55 years old have a 90% chance of developing hypertension during their lifetime.", "Gastric lavage is an effective treatment for acute paraquat poisoning.", "Ambulatory blood pressure monitoring is inaccurate at diagnosing hypertension.", "Type 1 Diabetes is associated with subtle perturbations in T reg development."], "hard_negatives": ["The density of cytokine receptor bearing cells affects the distance over which cytokines act.", "The density of cytokine receptor bearing cells has no effect on the distance over which cytokines act.", "Primary pro-inflammatory cytokines suppress secondary pro- and anti-inflammatory mediators.", "Major antigen-induced signals from the T cell receptor and secondary signals from costimulatory receptors are required for T cell activation.", "Many transmembrane receptors transmit signals by long-range conformational changes in the association of alpha-helices across the plasma membrane.", "T cell receptor /CD3 microdomains are required to induce the immunologic synapse.", "The cytokine receptor which regulates chemotaxis and formation of lymph nodes is involved in production of myeloperoxidase in the left atrium.", "Pro-inflammatory cytokines are up regulated during tumor development.", "The effect of Lipopolysaccharides on kidney barrier function is dependent on inflammation levels.", "Many cytokines that are produced by cancer cells also contribute to carcinogenesis."], "hard_negative": "The density of cytokine receptor bearing cells affects the distance over which cytokines act."}
{"query_id": "1211", "query_text": "The density of cytokine receptor bearing cells has no effect on the distance over which cytokines act.", "negative": "Having a main partner worsens HIV outcomes.", "negatives": ["Having a main partner worsens HIV outcomes.", "Energy balance requires hypothalamic glutamate neurotransmission.", "TMEM27 is a marker for beta cells.", "NR5A2 is important in reverse cholesterol transport in humans.", "Monoclonal antibody targeting of N-cadherin encourages metastasis.", "Including pharmacists in rounding teams does not alter the incidence of adverse drug events (ADEs).", "Cis-acting lncRNAs control the expression of genes that are positioned in the vicinity of their transcription sites.", "The DESMOND program demonstrates no significant impact on weight loss.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have longer lifetime exposure to estrogen due to an increased reproductive period.", "BLM gene encodes RecQ-class DNA helicase."], "hard_negatives": ["The density of cytokine receptor bearing cells has no effect on the distance over which cytokines act.", "The density of cytokine receptor bearing cells affects the distance over which cytokines act.", "Primary pro-inflammatory cytokines suppress secondary pro- and anti-inflammatory mediators.", "Major antigen-induced signals from the T cell receptor and secondary signals from costimulatory receptors are required for T cell activation.", "Many transmembrane receptors transmit signals by long-range conformational changes in the association of alpha-helices across the plasma membrane.", "T cell receptor /CD3 microdomains are required to induce the immunologic synapse.", "Pro-inflammatory cytokines are up regulated during tumor development.", "The effect of Lipopolysaccharides on kidney barrier function is dependent on inflammation levels.", "The cytokine receptor which regulates chemotaxis and formation of lymph nodes is involved in production of myeloperoxidase in the left atrium.", "Many cytokines that are produced by cancer cells also contribute to carcinogenesis."], "hard_negative": "The density of cytokine receptor bearing cells has no effect on the distance over which cytokines act."}
{"query_id": "1212", "query_text": "The deregulated and prolonged activation of monocytes has deleterious effects in chronic infectious conditions.", "negative": "Smc5/6 engagment halts the activation of SUMO E3 ligase Mms21 by ATP-dependent remolding.", "negatives": ["Smc5/6 engagment halts the activation of SUMO E3 ligase Mms21 by ATP-dependent remolding.", "A high microerythrocyte count protects against severe anemia in homozygous alpha (+)- thalassemia trait subjects.", "Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 inhibit West Nile virus replication in cortical neurons.", "Replacement of histone H2A with H2A.Z accelerates gene activation in yeasts by destabilizing +1 nucleosomes.", "Natriuretic peptides protect against diabetes.", "Lack of FGF21 in mice leads to atherosclerotic plaque formation.", "ART substantially reduces infectiveness of HIV-positive people.", "In rhesus macaques, daily subcutaneous injections of emtricitabine are ineffective at protecting against rectally transmitted simian-human immunodeficiency virus.", "CDK6 shows improved binding to loss-of-function variants of p18 INK4C.", "The artifactual C-terminal helix swapping in the StART domain is observed in the Ups1-Mdm35 heterodimer of the StARkin superfamily."], "hard_negatives": ["The deregulated and prolonged activation of monocytes has deleterious effects in chronic infectious conditions.", "The deregulated and prolonged activation of monocytes improves inflammatory disease outcomes.", "Chronic HIV stimulation of B cells leads to the premature exhaustion of B cells.", "Differentiation of progenitor cells to myeloid cells is skewed when insulin signaling is suppressed.", "Cancer cells can stimulate the accumulation of intra-tumoural myeloid-derived suppressor cells by promoting granulocyte colony stimulating factor production.", "Exhaustion of B cells contributes to poor Ab response in HIV-infected individuals.", "Differentiation of progenitor cells to myeloid cells is skewed upon activation of insulin signaling.", "CD28 signals regulate trafficking of murine auto-reactive T cells into target tissues.", "Tuberculosis-induced granulomas express different immune system protein signatures than the surrounding tissue.", "PD-1 triggering on monocytes enhances IL-10 production by monocytes."], "hard_negative": "The deregulated and prolonged activation of monocytes has deleterious effects in chronic infectious conditions."}
{"query_id": "1214", "query_text": "The deregulated and prolonged activation of monocytes improves inflammatory disease outcomes.", "negative": "Lice attenuated SIV vaccines induce a stronger antigen-specific T cell response in lymph node cells.", "negatives": ["Lice attenuated SIV vaccines induce a stronger antigen-specific T cell response in lymph node cells.", "Vaccinating the gastrointestinal tract induces protection of rectal and vaginal mucosa.", "The TRaF1/C5 rs10818488 allele polymorphism regulates the neighboring C5 gene.", "Major vault protein (MVP) leads to more aggressive tumors by regulating the sorting of tumor suppressive miR-193a into extracellular vesicles (EVs).", "Active Ly49Q induces neutrophil polarization.", "61% of colorectal cancer patients are diagnosed with regional or distant metastases.", "BCL-2 activation antagonizes the apoptotic effects of c-Myc.", "aPKCz causes tumour suppression by affecting glutamine metabolism.", "PKG-la does not have a large impact on expression of spinal long term potentiation in PGK-la knockout mice.", "TRAP+ osteoclasts regulate mature osteoblast maintenance."], "hard_negatives": ["The deregulated and prolonged activation of monocytes improves inflammatory disease outcomes.", "The deregulated and prolonged activation of monocytes has deleterious effects in chronic infectious conditions.", "PD-1 triggering on monocytes enhances IL-10 production by monocytes.", "AMP-activated protein kinase (AMPK) activation reduces inflammation-related fibrosis in the lungs.", "Enhanced early production of inflammatory chemokines damages viral control in the lung.", "IL-10 production by monocytes inhibits CD4 + T cell response.", "Tumor development occurs in conjunction with upregulation of pro-inflammatory cytokines.", "The effect of Lipopolysaccharides on kidney barrier function is dependent on inflammation levels.", "Induced hepatic stem cells possess the potential to differentiate into cholangiocytic cells.", "Differentiation of progenitor cells to myeloid cells is skewed when insulin signaling is suppressed."], "hard_negative": "The deregulated and prolonged activation of monocytes improves inflammatory disease outcomes."}
{"query_id": "1215", "query_text": "The effect of Lipopolysaccharides on kidney barrier function is dependent on inflammation levels.", "negative": "Birth-weight is negatively associated with breast cancer.", "negatives": ["Birth-weight is negatively associated with breast cancer.", "Deltex interacts with eIF3. There is no known interaction between Deltex and elF3", "Long - range chromatin interactions regulate transcription.", "Mice defective for deoxyribonucleic acid (DNA) polymerase I (polI) fail to reveal increased sensitivity to ionizing radiation (IR).", "Mutations in RIM1 decrease levels of IME1 RNA.", "Kir7.1 modulates channel activity by the G protein-coupled melanocortin-4 receptor (MC4R) in the paraventricular nucleus of the hypothalamus.", "Deletion of ATM and Rad3 related protein is not predictive of acute tissue loss.", "Cancer-associated fibroblasts (CAFs) interact with cancer cells to mediate formation and activation of CAFs.", "90% of patients with melanoma and an objective response to PD-1 blockade will experience a progression in their melanoma.", "RUNX is not expressed in skin tissue."], "hard_negatives": ["The effect of Lipopolysaccharides on kidney barrier function is dependent on inflammation levels.", "Lipopolysaccharides have an inflammation independent effect on kidney barrier function.", "Angiotensin converting enzyme inhibitors are associated with decreased risk for functional renal insufficiency.", "AMP-activated protein kinase (AMPK) activation reduces inflammation-related fibrosis in the lungs.", "NAC destabilizes NO to increase the effect of contrast agents on renal functions.", "The density of cytokine receptor bearing cells affects the distance over which cytokines act.", "The density of cytokine receptor bearing cells has no effect on the distance over which cytokines act.", "Depletion of nitric oxide is responsible for vasospasm.", "Reduced levels of lipolysis leads to higher P38 phosphorylation in adipose tissue.", "Autophagy deficiency in the liver increases vulnerability to insulin resistance."], "hard_negative": "The effect of Lipopolysaccharides on kidney barrier function is dependent on inflammation levels."}
{"query_id": "1218", "query_text": "The first MBT repeat of the four malignant brain tumor (4MBT) domain of Drosophila's Sfmbt and of the orthologous mammalian L3MBTL2 is required for the interaction with the spacer region of Drosophila's Pleiohomeotic (Pho) or its human ortholog YY1.", "negative": "Pro-inflammatory cytokines are up regulated during tumor development.", "negatives": ["Pro-inflammatory cytokines are up regulated during tumor development.", "Reduction of Rpl38 alters the composition of the Hox gene mRNAs translation in mice without lowering overall protein synthesis.", "Bcp1 is a chaperone for Rpl23.", "MT binding domain drives amyloid structure formation.", "F4/80+ macrophages regulate mature osteoblast maintenance.", "mcm 5 s 2 U is required for proper decoding of NNR codons in eukaryotes.", "The proliferative capacity of progenitors is regulated cell-autonomously.", "The DESMOND program demonstrates no significant impact on lifestyles outcomes.", "Differentiation of progenitor cells to myeloid cells is skewed upon activation of insulin signaling.", "Malaria has a high vectorial capacity."], "hard_negatives": ["The first MBT repeat of the four malignant brain tumor (4MBT) domain of Drosophila's Sfmbt and of the orthologous mammalian L3MBTL2 is required for the interaction with the spacer region of Drosophila's Pleiohomeotic (Pho) or its human ortholog YY1.", "The PPR MDA5 has twenty N-terminal CARD domains.", "Mutations in G-Beta protein GNB1 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.", "Glioblastoma multiforme (GBM) is characterized by extensive invasion, rapid growth, necrosis, and angiogenesis.", "The PRR MDA5 has a C-terminal domain.", "Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes fibrosis.", "The artifactual C-terminal helix swapping in the StART domain is observed in the Ups1-Mdm35 heterodimer of the StARkin superfamily.", "L3MBTL2 binds to H2AK119Ub marked chromatin to form a PRC1 complex.", "Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes epithelial damage.", "JMJD6 slows the hydroxylation of C-terminal lysine"], "hard_negative": "The first MBT repeat of the four malignant brain tumor (4MBT) domain of Drosophila's Sfmbt and of the orthologous mammalian L3MBTL2 is required for the interaction with the spacer region of Drosophila's Pleiohomeotic (Pho) or its human ortholog YY1."}
{"query_id": "1219", "query_text": "The gene daf-16, which encodes forkhead Box O (FOXO), is required for all phenotypes associated with reduced insulin/insulin-like growth factor (Igf) signaling.", "negative": "Patients in stable partnerships progress from HIV to death at the same rate as patients not in partnerships.", "negatives": ["Patients in stable partnerships progress from HIV to death at the same rate as patients not in partnerships.", "Pseudoknots are not evolutionarily conserved in most eukaryotes.", "ART has no effect on the infectiveness of HIV-positive people.", "Klf4 is important for proper myeloid cell differentiation.", "Pyridostatin stabilizes the G - quadruplex in the telomeric region.", "p75 NTR - associated cell death executor (NADE) interacts with the p75 NTR death domain", "Low expression of miR7a does not repress target genes or exert a biological function in ovaries.", "Myelin sheaths play a role in action potential propagation.", "In the UK, drowning affects boys and girls equally.", "Activated Cdk5 regulates DNA damage-induced neuronal death."], "hard_negatives": ["The gene daf-16, which encodes forkhead Box O (FOXO), is required for all phenotypes associated with reduced insulin/insulin-like growth factor (Igf) signaling.", "FoxO3a activation in neuronal death is inhibited by reactive oxygen species (ROS).", "The minor G allele of FOXO3 is related to less severe symptoms of Crohn's Disease.", "The minor G allele of FOXO3 up-regulates IL-10.", "The minor G allele of FOXO3 downregulates pro-inflammatory cytokines.", "The G34R/V mutation does not create a hypomethylated phenotype at the H3K36 histone.", "Forkhead 0 (fox0) transcription factors are involved in cellular differentiation.", "Forkhead 0 (fox0) transcription factors are involved in apoptosis.", "The G34R/V mutation creates a hypomethylated phenotype at the H3K36 histone.", "KRT17 modulates the expression of the transcriptional regulator AIRE in diseased epithelia."], "hard_negative": "The gene daf-16, which encodes forkhead Box O (FOXO), is required for all phenotypes associated with reduced insulin/insulin-like growth factor (Igf) signaling."}
{"query_id": "1220", "query_text": "The generation of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells.", "negative": "Aged patients are more susceptible to ischaemia/reperfusion injury.", "negatives": ["Aged patients are more susceptible to ischaemia/reperfusion injury.", "The appearance of brown-like or beige cells primarily occurs in visceral fat, not subcutaneous fat.", "Propriospinal interneurons that play a role in the plastic reorganization of spinal circuits are integral for recovery from spinal cord injury.", "ITAM phosphorylation allows for the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).", "76-85% of people with severe mental disorder receive no treatment in low and middle income countries.", "Whole brain radiotherapy increases the occurrence of new brain metastases.", "The generation of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells.", "MafA ubiquitination increases the recruitment of coavtivator P/CAF by MafA.", "Elevated cell-free mitochondrial DNA levels are associated with mortality.", "Reduced phosphorylation of PP2A increases HDAC4 dephosphorylation by enhancing PP2A-HDAC4 interaction."], "hard_negatives": ["The generation of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells.", "The removal of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells.", "Carriers of HNF4A mutations are at reduced risk for diabetes.", "Ethanol stress lowers the expression of PSP in bacteria.", "There is no association between HNF4A mutations and diabetes risks.", "HNF4A mutations are associated with macrosomia in infancy.", "Ethanol stress increases the expression of IBP in bacteria.", "Ethanol stress increases the expression of PSP in bacteria.", "Low nucleosome occupancy correlates with high methylation levels across species.", "Ethanol stress reduces the expression of SRL in bacteria."], "hard_negative": "The generation of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells."}
{"query_id": "1223", "query_text": "The innate immune response struggles to remove small numbers of parasites.", "negative": "FACT and other histone chaperone(s) compensate for Histone 2A (H2A)-histone 2B (H2B) dimer eviction during the histone exchange process.", "negatives": ["FACT and other histone chaperone(s) compensate for Histone 2A (H2A)-histone 2B (H2B) dimer eviction during the histone exchange process.", "Angiotensin converting enzyme inhibitors are associated with decreased risk for functional renal insufficiency.", "Stroke patients with prior use of direct oral anticoagulants have a higher risk of in-hospital mortality than stroke patients with prior use of warfarin.", "Splenomegaly is observed in knockin mouse lacking the SHP-2 MAPK pathway.", "Therapeutics receiving accelerated approval encounter a lower frequency of post-marketing safety events", "Pyridostatin prevents double-strand breaks accumulation.", "Insulin decreases risk of severe kidney failure.", "Cell autonomous sex determination in somatic cells occurs in Galliformes.", "M. stadtmanae induces ASC speck formation in BlaER1 monocytes.", "The number of unfertilized oocytes in mated hermaphrodites increases with age."], "hard_negatives": ["The innate immune response struggles to remove small numbers of parasites.", "Inside the body, falciparum parasites reproduce asexually.", "Immune responses in immune cells are geographically segregated.", "Malaria has a high vectorial capacity.", "Microglia are an innate immune cell type of the central nervous system.", "Nonhuman primates are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.", "Microglia are an innate immune cell type of the peripheral nervous system.", "Increased flux of microbial products provokes immune responses.", "Increased flux of microbial products suppresses immune responses.", "Eilat virus (EILV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in nonhuman primates."], "hard_negative": "The innate immune response struggles to remove small numbers of parasites."}
{"query_id": "1224", "query_text": "The latent infection of myeloid cells with human cytomegalovirus induces a number of changes in gene expression.", "negative": "BCL-2 activation antagonizes the apoptotic effects of c-Myc.", "negatives": ["BCL-2 activation antagonizes the apoptotic effects of c-Myc.", "Reduced responsiveness to interleukin-2 in regulatory T cells is associated with autoimmune diseases such as Type 1 Diabetes.", "Antiretroviral therapy increases rates of tuberculosis across a broad range of CD4 strata.", "The G34R/V mutation creates a hypomethylated phenotype at the H3K36 histone.", "Reduction of Rpl38 alters the composition of the Hox gene mRNAs translation in mice without lowering overall protein synthesis.", "CRP is positively correlated with postoperative mortality following Coronary Artery Bypass Graft (CABG) surgery.", "miRNAs regulate a unique suite of mRNAs to maintain homeostasis in cells.", "British female students are bullied more than British male students.", "Integrating classroom-based collaborative learning with Web-based collaborative learning offers the best class performance.", "HSCT-T dosage may not be diagnostic if the onset of symptoms occurs less than 3 hours before AMI."], "hard_negatives": ["The latent infection of myeloid cells with human cytomegalovirus induces a number of changes in gene expression.", "Mice that lack Interferon-\u03b3 or its receptor are highly susceptible to experimental autoimmune myocarditis.", "Eilat virus (EILV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in nonhuman primates.", "Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 encourage West Nile virus replication in cortical neurons.", "Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 inhibit West Nile virus replication in cortical neurons.", "Tuberculosis-induced granulomas express different immune system protein signatures than the surrounding tissue.", "Rising temperatures caused by global warming increases risk of dengue fever transmission.", "Nonhuman primates are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.", "Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection increases dissemination of Salmonella Typhimurium from the gut.", "Rising temperatures caused by global warming lowers the risk of dengue fever transmission."], "hard_negative": "The latent infection of myeloid cells with human cytomegalovirus induces a number of changes in gene expression."}
{"query_id": "1227", "query_text": "The mean suicide rate in women is higher after miscarriage than live birth.", "negative": "Deletion of ATM and Rad3 related protein leads to acute tissue loss.", "negatives": ["Deletion of ATM and Rad3 related protein leads to acute tissue loss.", "Induced hepatic stem cells possess the potential to differentiate into cholangiocytic cells.", "Bacterial meningitis can be diagnosed on the basis of positive cerebrospinal fluid (CSF) cultures.", "Emodin forms hydrogen bonds with residues involved in PGAM1 substrate binding.", "Increased vessel density along with a reduction in fibrosis improves the efficacy of chemotherapy treatments.", "Ribosomal protein (RP) expression is controlled in part by stress-activated regulators.", "The risk of cancer rises with level of alcohol consumption.", "Cytosolic proteins bind to iron-responsive elements on mRNAs coding for TFRC1.", "The minor G allele of FOXO3 downregulates pro-inflammatory cytokines.", "Incidence of sepsis has fallen substantially from 2009 to 2014."], "hard_negatives": ["The mean suicide rate in women is lower after miscarriage than live birth.", "The mean suicide rate in women is higher after miscarriage than live birth.", "90% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.", "10% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.", "53% of perinatal mortality is due to low birth weight.", "Incidence of heart failure increased by 10% in women since 1979.", "Women with a lower birth weight are more likely to develop breast cancer later in life.", "The risk of breast cancer among parous women decreases with placental weight of pregnancies.", "Sepsis related mortality has risen from 2009 to 2014.", "Birth-weight is negatively associated with breast cancer."], "hard_negative": "The mean suicide rate in women is lower after miscarriage than live birth."}
{"query_id": "1228", "query_text": "The mean suicide rate in women is lower after miscarriage than live birth.", "negative": "90% of patients with melanoma and an objective response to PD-1 blockade will experience a progression in their melanoma.", "negatives": ["90% of patients with melanoma and an objective response to PD-1 blockade will experience a progression in their melanoma.", "It is not proven that moderate consumption of candy and chocolate reduces the risk of cardiovascular disease (CVD) specifically.", "Patients with common epithelial cancers are less likely to have an emergency event as their first hospital admission if they live in resource-deprived areas.", "Distant CREs are important for transcriptional regulation.", "ATM and Rad3 related protein are critical for sensing DNA damage.", "Pioglitazone use is significantly associated with an increased risk of prostate cancer.", "Chinese individuals with TT homozygosity in the MTHFR gene are more vulnerable to strokes caused by low levels of folate intake.", "Primary cervical cancer screening with HPV detection has lower longitudinal sensitivity than conventional cytology to detect cervical intraepithelial neoplasia grade 2.", "The effect of Lipopolysaccharides on kidney barrier function is dependent on inflammation levels.", "Neutrophil extracellular trap (NET) antigens may contain the targeted autoantigens PR3 and MPO."], "hard_negatives": ["The mean suicide rate in women is lower after miscarriage than live birth.", "The mean suicide rate in women is higher after miscarriage than live birth.", "90% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.", "10% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.", "53% of perinatal mortality is due to low birth weight.", "Women with a lower birth weight are more likely to develop breast cancer later in life.", "The risk of breast cancer among parous women decreases with placental weight of pregnancies.", "Incidence of heart failure increased by 10% in women since 1979.", "Sepsis related mortality has risen from 2009 to 2014.", "Birth-weight is negatively associated with breast cancer."], "hard_negative": "The mean suicide rate in women is lower after miscarriage than live birth."}
{"query_id": "1229", "query_text": "The microtubule-dependent delivery and secretion of matrix metalloproteases (MMPs) is partially responsible for the disassembly of adhesion sites.", "negative": "Prescribed exercise training improves quality of life.", "negatives": ["Prescribed exercise training improves quality of life.", "Cancer-associated fibroblasts (CAFs) are constituents of tumor microenvironments", "Monoclonal antibody targeting of N-cadherin encourages castration resistance.", "Lipopolysaccharides have an inflammation independent effect on kidney barrier function.", "Replacement of histone H2A with H2A.Z accelerates gene activation in yeasts by destabilizing +1 nucleosomes.", "MFGE8 regulates fat absorption by binding to av-Beta3 and av-Beta5 integrins.", "RUNX1 is downregulated or mutated in TLX1 T-ALL.", "Commelina yellow mottle virus (ComYMV) has three typical badnavirus ORFs, capable of encoding proteins 23, 15, and 216 kD.", "Sudden death can occur in patients with orthostatic hypertension without cardiac conduction abnormalities.", "Pro-inflammatory cytokines are up repressed during tumor development."], "hard_negatives": ["The microtubule-dependent delivery and secretion of matrix metalloproteases (MMPs) is partially responsible for the disassembly of adhesion sites.", "Intramembrane cleavage by signal peptide peptidase aids in the degradation of proteins with a complex membrane orientation.", "Myelin sheaths are lipid-rich cellular structures.", "MafA ubiquitination increases the recruitment of coavtivator P/CAF by MafA.", "MafA ubiquitination decreases the recruitment of coavtivator P/CAF by MafA.", "Lamins have no effect on nuclear membrane structure maintenance.", "Inhibiting focal adhesion formation enables cells to convert mechanical strain into eventual scarring.", "Inhibiting focal adhesion formation increases the rate at which cells convert mechanical strain into inflammation and fibrosis.", "Cancer-associated fibroblasts (CAFs) interact with cancer cells to mediate formation and activation of CAFs.", "Reduction of purity of cytoplasmic membranes isolated from overexpressors is indicated by stronger spots for OmpA in 2D BN-PAGE gels."], "hard_negative": "The microtubule-dependent delivery and secretion of matrix metalloproteases (MMPs) is partially responsible for the disassembly of adhesion sites."}
{"query_id": "1230", "query_text": "The minor G allele of FOXO3 downregulates pro-inflammatory cytokines.", "negative": "Stroke patients with prior use of direct oral anticoagulants have a higher risk of in-hospital mortality than stroke patients with prior use of warfarin.", "negatives": ["Stroke patients with prior use of direct oral anticoagulants have a higher risk of in-hospital mortality than stroke patients with prior use of warfarin.", "The DESMOND program demonstrates no significant impact on weight loss.", "Origin gross domestic product(GDP) is negatively related to dengue virus (DENV-1) diffusion in air traffic shipments.", "Students who perform poorly in the early years of medical school are less likely to commit professional misconduct later in their careers.", "Omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegans.", "Major vault protein regulates sorting of tumor suppressive miR-193a into EVs.", "Certain immunomodulator-human dialyzable leukocyte extract (hDLE) peptides are recognized by toll-like receptors (TLRs) on macrophages and dendritic cells.", "Decreased conversion of PGE 2 to PPARy ligand 15-ket-PGE 2 causes accumulation of PGE.", "Hypocretin neurones suppress panicprone state in rats.", "taa1 tar1 tar2 triple mutants in Arabidopsis do not make root meristem during embryogenesis."], "hard_negatives": ["The minor G allele of FOXO3 downregulates pro-inflammatory cytokines.", "The minor G allele of FOXO3 up-regulates IL-10.", "The minor G allele of FOXO3 is related to less severe symptoms of Crohn's Disease.", "FoxO3a activation in neuronal death is inhibited by reactive oxygen species (ROS).", "Foxk2 regulates autophagy genes in muscle cells and fibroblast cells.", "Foxp3 represses the expression of transcriptional regulators implicated in memory T cell development.", "Foxp3 enables the expression of transcriptional regulators implicated in memory T cell development.", "Mutations in G-Beta protein GNB1 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.", "The gene daf-16, which encodes forkhead Box O (FOXO), is required for all phenotypes associated with reduced insulin/insulin-like growth factor (Igf) signaling.", "PKG-la does not have a large impact on expression of pain hypersensitivity in PGK-la knockout mice."], "hard_negative": "The minor G allele of FOXO3 downregulates pro-inflammatory cytokines."}
{"query_id": "1231", "query_text": "The minor G allele of FOXO3 is related to less severe symptoms of Crohn's Disease.", "negative": "Active H. pylori urease has a polymeric structure consisting of five distinct subunits.", "negatives": ["Active H. pylori urease has a polymeric structure consisting of five distinct subunits.", "Phase information is useful for predicting donor-recipient matches in organ transplantation.", "PCSK9 inhibitors decrease plasma Lp(a) levels.", "In the UK, drowning affects boys and girls equally.", "AZT given with ribavirin increases anemia.", "Egr3 regulates the homeostasis of B and T cells.", "Mouse models can be generated using \"artificial spermatids.\"", "The Snf1 complex regulates carbon and energy metabolism in baker's yeast (Saccharomyces cerevisiae).", "The morphology change from large white adipocytes to small brown adipocytes is a sign of increased energy expenditure potential in white adipose tissue.", "N348I mutations reduce resistance to nevirapine."], "hard_negatives": ["The minor G allele of FOXO3 is related to less severe symptoms of Crohn's Disease.", "The minor G allele of FOXO3 up-regulates IL-10.", "The minor G allele of FOXO3 downregulates pro-inflammatory cytokines.", "The gene daf-16, which encodes forkhead Box O (FOXO), is required for all phenotypes associated with reduced insulin/insulin-like growth factor (Igf) signaling.", "FoxO3a activation in neuronal death is inhibited by reactive oxygen species (ROS).", "The G34R/V mutation does not create a hypomethylated phenotype at the H3K36 histone.", "Mutations in G-Beta protein GNB1 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.", "The G34R/V mutation creates a hypomethylated phenotype at the H3K36 histone.", "Foxp3 represses the expression of transcriptional regulators implicated in memory T cell development.", "Foxk2 regulates autophagy genes in muscle cells and fibroblast cells."], "hard_negative": "The minor G allele of FOXO3 is related to less severe symptoms of Crohn's Disease."}
{"query_id": "1234", "query_text": "The minor G allele of FOXO3 up-regulates IL-10.", "negative": "The US health care system can save up to $5 billion if 7% of patients waiting for kidney transplants participate in the optimized national kidney paired donation program.", "negatives": ["The US health care system can save up to $5 billion if 7% of patients waiting for kidney transplants participate in the optimized national kidney paired donation program.", "RUNX is not expressed in skin tissue.", "Exhaustion of B cells contributes to poor Ab response in HIV-infected individuals.", "Lamins have no effect on nuclear membrane structure maintenance.", "Omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegetarians.", "Notch signaling occurs between tumor cells and stromal cells.", "MafA ubiquitination increases the recruitment of coavtivator P/CAF by MafA.", "Cnn1 recruitment varies with cell cycle timing.", "mcm 5 s 2 U is required for proper decoding of NNR codons in eukaryotes.", "Drosophila supracellular actomyosin structures are found at boundaries in wing imaginal discs."], "hard_negatives": ["The minor G allele of FOXO3 up-regulates IL-10.", "The minor G allele of FOXO3 downregulates pro-inflammatory cytokines.", "The minor G allele of FOXO3 is related to less severe symptoms of Crohn's Disease.", "FoxO3a activation in neuronal death is inhibited by reactive oxygen species (ROS).", "Foxp3 represses the expression of transcriptional regulators implicated in memory T cell development.", "Foxk2 regulates autophagy genes in muscle cells and fibroblast cells.", "Foxp3 enables the expression of transcriptional regulators implicated in memory T cell development.", "The gene daf-16, which encodes forkhead Box O (FOXO), is required for all phenotypes associated with reduced insulin/insulin-like growth factor (Igf) signaling.", "TNFAIP3 is a glioblastoma tumor suppressor.", "IL-6 signaling plays a major role in atherosclerotic cardiovascular disease."], "hard_negative": "The minor G allele of FOXO3 up-regulates IL-10."}
{"query_id": "1235", "query_text": "The morphology change from large white adipocytes to small brown adipocytes is a sign of decreased energy expenditure potential in white adipose tissue.", "negative": "Pharmacist attendance at ward rounds increases adverse events in wards.", "negatives": ["Pharmacist attendance at ward rounds increases adverse events in wards.", "The proportion of people with visual difficulty is two times higher in low-income countries than in high-income countries.", "Having a main partner improves HIV outcomes.", "Mouse models can be generated using \"artificial spermatids.\"", "53% of perinatal mortality is due to low birth weight.", "Acute ablation of Snail in the embryonic cortex affects the proliferation and number of embryonic cortical precursors.", "Increased purity of cytoplasmic membranes isolated from overexpressors is indicated by stronger spots for OmpF in 2D BN-PAGE gels.", "EGR2 is important to myelination of the peripheral nervous system.", "Certain immunomodulator-human dialyzable leukocyte extract (hDLE) peptides are recognized by toll-like receptors (TLRs) on macrophages and dendritic cells.", "Deltex interacts with eIF3. There is no known interaction between Deltex and elF3"], "hard_negatives": ["The morphology change from large white adipocytes to small brown adipocytes is a sign of decreased energy expenditure potential in white adipose tissue.", "The morphology change from large white adipocytes to small brown adipocytes is a sign of increased energy expenditure potential in white adipose tissue.", "The M2-phenotype in brown adipose tissue macrophages increases brown adipose tissue thermogenic activity.", "Chenodeoxycholic acid treatment decreases brown adipose tissue activity.", "Chenodeoxycholic acid treatment increases brown adipose tissue activity.", "Ca2+ cycling controls whole-body energy homeostasis in beige fat.", "Increased lipolysis leads to higher P38 phosphorylation in adipose tissue.", "Reduced levels of lipolysis leads to higher P38 phosphorylation in adipose tissue.", "An M2-like phenotype in brown adipose tissue macrophages is quickly induced by cold exposure.", "The appearance of brown-like or beige cells primarily occurs in visceral fat, not subcutaneous fat."], "hard_negative": "The morphology change from large white adipocytes to small brown adipocytes is a sign of decreased energy expenditure potential in white adipose tissue."}
{"query_id": "1236", "query_text": "The morphology change from large white adipocytes to small brown adipocytes is a sign of increased energy expenditure potential in white adipose tissue.", "negative": "RTEL1 interacts with TRF2 through a C4C4 motif", "negatives": ["RTEL1 interacts with TRF2 through a C4C4 motif", "ATM and Rad3 related protein have no role in sensing DNA damage.", "Pioglitazone use is significantly associated with an increased risk of pancreatic cancer.", "LSD1-positive promoters are associated with RNA polymerase II", "PKG-la plays an essential role in expression of spinal long term potentiation in PGK-la knockout mice.", "Higher plasma levels of I-carnitine, when associated with trimethylamine N-oxide, are positively correlated with cardiovascular events in humans.", "Weighed food records (WFR) result in poor completion since they're costly to run and impose high participant burden.", "Thiopurine active metabolites can be catabolized through dephosphorylation of thioguanine nucleotides.", "Low nucleosome occupancy correlates with high methylation levels across species.", "CCL19 is predominantly present within dLNs."], "hard_negatives": ["The morphology change from large white adipocytes to small brown adipocytes is a sign of increased energy expenditure potential in white adipose tissue.", "The morphology change from large white adipocytes to small brown adipocytes is a sign of decreased energy expenditure potential in white adipose tissue.", "The M2-phenotype in brown adipose tissue macrophages increases brown adipose tissue thermogenic activity.", "Ca2+ cycling controls whole-body energy homeostasis in beige fat.", "Chenodeoxycholic acid treatment increases brown adipose tissue activity.", "Chenodeoxycholic acid treatment decreases brown adipose tissue activity.", "Increased lipolysis leads to higher P38 phosphorylation in adipose tissue.", "Reduced levels of lipolysis leads to higher P38 phosphorylation in adipose tissue.", "An M2-like phenotype in brown adipose tissue macrophages is quickly induced by cold exposure.", "The appearance of brown-like or beige cells primarily occurs in visceral fat, not subcutaneous fat."], "hard_negative": "The morphology change from large white adipocytes to small brown adipocytes is a sign of increased energy expenditure potential in white adipose tissue."}
{"query_id": "1237", "query_text": "The most prevalent adverse events to Semaglutide are cardiovascular.", "negative": "GATA3 regulates cell cycle progression in bone marrow hematopoietic stem cells.", "negatives": ["GATA3 regulates cell cycle progression in bone marrow hematopoietic stem cells.", "Cancer-associated fibroblasts (CAFs) are constituents of tumor microenvironments", "Stiff substrates inhibit mesodermal differentiation by degrading beta-catenin in an integrin-dependent manner.", "Microcin J25 inhibits nucleoside triphosphate (NTP) binding.", "JMJD6 slows the hydroxylation of C-terminal lysine", "Broadly HIV-1 Neutralizing Antibodies (bnAb) 10EB have no affinity for phospholipids.", "CD28 signals regulate trafficking of murine auto-reactive T cells into target tissues.", "Ethanol stress lowers the expression of PSP in bacteria.", "There was an estimated 30 million cases of pneumonia in young children worldwide in 2010.", "Removal of H3K9me3 improves reprogramming efficiency in human somatic cell nuclear transfer experiments."], "hard_negatives": ["The most prevalent adverse events to Semaglutide are cardiovascular.", "The most prevalent adverse events to Semaglutide are gastrointestinal.", "Side effects associated with antidepressants increases risk of stroke.", "Side effects associated with antidepressants do not represent a mortality risk to postmenopausal women.", "Sildenafil worsens erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.", "Side effects associated with antidepressants lower risk of myocardial infarction.", "Taking anti-depresents is associated with a decrease in the A\u03b2 level in the brain of experimental animals.", "In young and middle-aged adults, current or remote uses of ADHD medications increase the risk of serious cardiovascular events.", "A breast cancer patient's capacity to metabolize tamoxifen influences treatment outcome.", "Nonsteroidal antinflammatory drugs show potential anticancer indications."], "hard_negative": "The most prevalent adverse events to Semaglutide are cardiovascular."}
{"query_id": "1238", "query_text": "The most prevalent adverse events to Semaglutide are gastrointestinal.", "negative": "Cis-acting lncRNAs control the expression of genes that are positioned in the vicinity of their transcription sites.", "negatives": ["Cis-acting lncRNAs control the expression of genes that are positioned in the vicinity of their transcription sites.", "Gastric lavage is an effective treatment for acute paraquat poisoning.", "Patients in stable partnerships have a slower progression from HIV to AIDS.", "H4 G94P proteins induce degradation of free histones via Rad53-dependent mechanisms.", "Adult tissue-resident macrophages stem from the embryonal yolk sac and fetal liver.", "FACT and other histone chaperone(s) compensate for Histone 2A (H2A)-histone 2B (H2B) dimer eviction during the histone exchange process.", "Including pharmacists in rounding teams does not alter the incidence of adverse drug events (ADEs).", "Pyridostatin encourages proliferation of homologous recombination - defective cells.", "Gastric infection with Helicobacter pylori decreases risk of gastric cancer in humans.", "Diminished ovarian reserve is a reliable indicator of infertility in a non-infertile population."], "hard_negatives": ["The most prevalent adverse events to Semaglutide are gastrointestinal.", "The most prevalent adverse events to Semaglutide are cardiovascular.", "Side effects associated with antidepressants increases risk of stroke.", "Side effects associated with antidepressants lower risk of myocardial infarction.", "Side effects associated with antidepressants do not represent a mortality risk to postmenopausal women.", "Sildenafil worsens erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.", "Pioglitazone use is significantly associated with an increased risk of pancreatic cancer.", "Taking anti-depresents is associated with a decrease in the A\u03b2 level in the brain of experimental animals.", "Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission.", "Antidepressants reduce the severity of migraines."], "hard_negative": "The most prevalent adverse events to Semaglutide are gastrointestinal."}
{"query_id": "1239", "query_text": "The myocardial cell lineage originally develops from cardiac progenitors of exclusively endodermal origin.", "negative": "Scapular stabilizer exercises are more effective than general exercise therapy in reducing pain and improving function of the shoulder.", "negatives": ["Scapular stabilizer exercises are more effective than general exercise therapy in reducing pain and improving function of the shoulder.", "The deregulated and prolonged activation of monocytes has deleterious effects in chronic infectious conditions.", "Long - range chromatin interactions regulate transcription.", "Nonhypertensive people who are 55 years old have a 90% chance of developing hypertension during their lifetime.", "MUC1-C activates the NF-\u03baB p65 signaling pathway by interacting with I\u03baB kinase \u00df.", "The repeat-variable diresidue (RVD) in the loop of Transcription-Activator Like (TAL) effectors specifies the nucleotides-amino acid contact at the target promoter element.", "Monoclonal antibody targeting of N-cadherin encourages castration resistance.", "Tonic signaling from the scFv is amplified by MyD88/CD40.", "The mean suicide rate in women is lower after miscarriage than live birth.", "HAND2 methylation is a key step in early endometrial carcinogenesis."], "hard_negatives": ["The myocardial cell lineage originally develops from cardiac progenitors of exclusively endodermal origin.", "Cardiac tissue-resident macrophages directly contribute to electrical activity.", "Differentiation of progenitor cells to myeloid cells is skewed upon activation of insulin signaling.", "Differentiation of progenitor cells to myeloid cells is skewed when insulin signaling is suppressed.", "Sudden death can occur in patients with orthostatic hypertension without cardiac conduction abnormalities.", "Human embryonic stem cells have the capacity to give rise to differentiated progeny representative of all three embryonic germ layers.", "Cellular differentiation of embryonic stem cells is accompanied by changes in replication timing, transcription and nuclear localization.", "Human embryonic stem cells give rise to cell types from all three embryonic germ layers.", "The PRDM1 gene is a key determinant of primordial germ cells.", "The proliferative capacity of progenitors is regulated cell-autonomously."], "hard_negative": "The myocardial cell lineage originally develops from cardiac progenitors of exclusively endodermal origin."}
{"query_id": "1244", "query_text": "The number of unfertilized oocytes in mated hermaphrodites increases with age.", "negative": "Chenodeoxycholic acid treatment increases brown adipose tissue activity.", "negatives": ["Chenodeoxycholic acid treatment increases brown adipose tissue activity.", "The tip of the inner tube of the toxic type VI secretion system (T6SS) antibacterial effector in Escherichia coli (E. coli) is decorated with VgrG and PAAR proteins.", "VgrG (Tssl) protein punctures membranes by forming a spike at the tip of the tube apparatus.", "4-PBA treatment raises endoplasmic reticulum stress in response to general endoplasmic reticulum stress markers.", "Urbanization is an important risk factor related to the transmission of dengue fever.", "In the UK, drowning affects boys and girls equally.", "The H2A-H2B eviction defect is compensated for by other histone chaperone(s).", "Intake of folic acid (FA) and vitamin B6 (VB6) increases levels of homocysteine.", "Microcin J25 inhibits nucleoside triphosphate (NTP) binding.", "Treatment with a protein named FN restores regenerative abilities of aged muscles."], "hard_negatives": ["The number of unfertilized oocytes in mated hermaphrodites increases with age.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have longer lifetime exposure to estrogen due to an increased reproductive period.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have shorter lifetime exposure to estrogen due to a decreased reproductive period.", "Cell autonomous sex determination in somatic cells occurs in Galliformes.", "Cellular differentiation of embryonic stem cells is accompanied by changes in replication timing, transcription and nuclear localization.", "A diminished ovarian reserve is a very strong indicator of infertility, even in an a priori non-infertile population.", "Diminished ovarian reserve is a reliable indicator of infertility in a non-infertile population.", "Mitochondria play a major role in energy production.", "A diminished ovarian reserve does not solely indicate infertility in an a priori non-infertile population.", "Human embryonic stem cells have the capacity to give rise to differentiated progeny representative of all three embryonic germ layers."], "hard_negative": "The number of unfertilized oocytes in mated hermaphrodites increases with age."}
{"query_id": "1246", "query_text": "The one-child policy has created a hospitable environment for female infants.", "negative": "Men are more susceptible to death due to pneumonia when compared to women.", "negatives": ["Men are more susceptible to death due to pneumonia when compared to women.", "Smc5/6 engagment halts the activation of SUMO E3 ligase Mms21 by ATP-dependent remolding.", "Continued HHV-8 transmission among MSM in San Francisco may be explained by urogenital contact.", "Inhibiting focal adhesion formation increases the rate at which cells convert mechanical strain into inflammation and fibrosis.", "Klf4 is important for proper myeloid cell differentiation.", "Pure neural progenitor cell (NPC) populations can only be obtained from cell cultures that undergo passaging, filtration, or other isolation and cell sorting methods.", "Oat tolerant coeliac patients may have oat specific inflammatory cells in their small bowel mucosa.", "Patients with microcytosis and higher erythrocyte count are more vulnerable to severe malarial anaemia when infected with Plasmodium falciparum.", "The NF-\u03baB essential modulator gene prevents intestinal inflammation by inhibiting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death.", "Participants who quit smoking reduce lung cancer risk by approximately 50%."], "hard_negatives": ["The one-child policy has created a hospitable environment for female infants.", "The mean suicide rate in women is lower after miscarriage than live birth.", "The mean suicide rate in women is higher after miscarriage than live birth.", "10% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.", "90% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.", "53% of perinatal mortality is due to low birth weight.", "For every 1,000 children with cerebral palsy, more than 300 of them are premature or underweight at birth.", "Birth-weight is negatively associated with breast cancer.", "A diminished ovarian reserve is a very strong indicator of infertility, even in an a priori non-infertile population.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have longer lifetime exposure to estrogen due to an increased reproductive period."], "hard_negative": "The one-child policy has created a hospitable environment for female infants."}
{"query_id": "1247", "query_text": "The origin of the CRF01_1b2k protein occurred between 1923 and 1956.", "negative": "RANK-RANKL pathway signalling is linked to development of Aire-expressing medullary thymic epithelial cells.", "negatives": ["RANK-RANKL pathway signalling is linked to development of Aire-expressing medullary thymic epithelial cells.", "L3MBTL2 binds to H2AK119Ub marked chromatin to form a PRC1 complex.", "Long chain polyunsaturated fatty acids supplementation has no significant effects on wheezing or asthma at 3 and 6 years.", "Antimicrobial agents are less effective due to the pressure of antimicrobial usage.", "Dexamethasone increases risk of postoperative bleeding.", "Sequence conservation in gene regulatory regions between species is a poor predictor of conserved functionality.", "A deficiency of vitamin B12 decreases blood levels of homocysteine.", "The morphology change from large white adipocytes to small brown adipocytes is a sign of increased energy expenditure potential in white adipose tissue.", "Weighed food records (WFR) result in high completion since they're cheap to run and impose low participant burden.", "TRAP+ osteoclasts regulate mature osteoblast maintenance."], "hard_negatives": ["The origin of the CRF01_1b2k protein occurred between 1923 and 1956.", "The predominant localization of Linc00173 is in mononuclear macrophage nuclei.", "Bcp1 is a chaperone for Rpl23.", "BLM gene encodes RecQ-class DNA helicase.", "KRT17 modulates the expression of the transcriptional regulator AIRE in diseased epithelia.", "A strong bias in the phage genome locations where the spacers were derived has been observed in many CRISPR subtypes that confer the immunity to phage.", "The Snf1 complex regulates carbon and energy metabolism in baker's yeast (Saccharomyces cerevisiae).", "ScPif1p has higher binding ability to G-rich ssDNA than to non-G-rich ssDNA.", "HNF4A mutations are associated with macrosomia in infancy.", "TMEM27 is a marker for beta cells."], "hard_negative": "The origin of the CRF01_1b2k protein occurred between 1923 and 1956."}
{"query_id": "1248", "query_text": "The peak incidence of fractures occurs during pubertal growth spurt in early adolescents.", "negative": "Induction of urokinase receptor signaling in podocytes causes foot process effacement and proteinuria.", "negatives": ["Induction of urokinase receptor signaling in podocytes causes foot process effacement and proteinuria.", "Tonic signaling from the scFv induces constitutive stimulation.", "ATF4 is a general endoplasmic reticulum stress marker.", "Removal of H3K9me3 by ectopic expression of other H3K9 demethylases improves reprogramming efficiency in SCNT experiments.", "Replacement of histone H2A with H2A.Z accelerates gene activation in yeasts by destabilizing +1 nucleosomes.", "Integrating classroom-based collaborative learning with Web-based collaborative learning offers the best class performance.", "Environmentally-induced senescence is mimicked in disease modeling by adding specific molecules to the culture system.", "Perigenital skin is not the primary site of HIV acquisition.", "Cyclin A2 destruction is necessary to switch from unstable to stable kt-mt attachments in mitosis.", "Adult tissue-resident macrophages are seeded before birth."], "hard_negatives": ["The peak incidence of fractures occurs during pubertal growth spurt in early adolescents.", "The peak incidence of fractures occurs in toddlers.", "10% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.", "90% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.", "Surgical treatment is not superior to non-surgical in treating adults with displaced fractures of the proximal humerus.", "There is a positive correlation between hip fractures and statin use.", "Chlamydia trachomatis is most prevalent in the UK among sexually-experienced individuals aged 16 to 24.", "The mean suicide rate in women is lower after miscarriage than live birth.", "The mean suicide rate in women is higher after miscarriage than live birth.", "53% of perinatal mortality is due to low birth weight."], "hard_negative": "The peak incidence of fractures occurs during pubertal growth spurt in early adolescents."}
{"query_id": "1249", "query_text": "The peak incidence of fractures occurs in toddlers.", "negative": "The microtubule-dependent delivery and secretion of matrix metalloproteases (MMPs) is partially responsible for the disassembly of adhesion sites.", "negatives": ["The microtubule-dependent delivery and secretion of matrix metalloproteases (MMPs) is partially responsible for the disassembly of adhesion sites.", "RA activation of DIF2 and NB4 cells induces hallmarks of transcriptionally active promoters.", "Vitamin D is an important factor in the relationship between calcium and parathyroid hormone.", "Alteration of origin firing causes changes in termination zones of Okazaki fragments.", "Risk-adjusted mortality rates are similar in teaching and non-teaching hospitals.", "ATF4 is a general endoplasmic reticulum stress marker.", "The mean suicide rate in women is lower after miscarriage than live birth.", "RAD52 is involved in break-induced DNA replication (BIR).", "Pediatric SCD patients with vaso-occlusive crisis show increased morphine use after breathing 80 ppm iNO for 4 hours.", "Bone Marrow (BM) transplantation is used to treat acute myeloid leukemia (AML)"], "hard_negatives": ["The peak incidence of fractures occurs in toddlers.", "The peak incidence of fractures occurs during pubertal growth spurt in early adolescents.", "10% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.", "90% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.", "Surgical treatment is not superior to non-surgical in treating adults with displaced fractures of the proximal humerus.", "There is a positive correlation between hip fractures and statin use.", "The mean suicide rate in women is lower after miscarriage than live birth.", "For every 1,000 children with cerebral palsy, more than 300 of them are premature or underweight at birth.", "The mean suicide rate in women is higher after miscarriage than live birth.", "53% of perinatal mortality is due to low birth weight."], "hard_negative": "The peak incidence of fractures occurs in toddlers."}
{"query_id": "1253", "query_text": "The predominant localization of Linc00173 is in mononuclear macrophage nuclei.", "negative": "The innate immune response struggles to remove small numbers of parasites.", "negatives": ["The innate immune response struggles to remove small numbers of parasites.", "Toll-like receptor (TLR) signaling is involved in the pathogenesis of human MDS.", "Reduced phosphorylation of PP2A suppresses HDAC4 dephosphorylation.", "aPKCz causes tumour suppression by affecting glutamine metabolism.", "General exercise therapy is more effective than rotator cuff exercises in reducing pain and improving function of the shoulder.", "There is a relation between Erythromycin use and hypertrophic pyloric stenosis.", "Ethanol stress increases the expression of PSP in bacteria.", "Interleukin-18 plays an important role in the pathogenesis of atherosclerosis.", "Sudden death can occur in patients with orthostatic hypertension without cardiac conduction abnormalities.", "ERAP1 SNPs are epistatic to HLA alleles for ankylosing spondylitis."], "hard_negatives": ["The predominant localization of Linc00173 is in mononuclear macrophage nuclei.", "The origin of the CRF01_1b2k protein occurred between 1923 and 1956.", "The PPR MDA5 has twenty N-terminal CARD domains.", "CCL19 is predominantly present within dLNs.", "mcm 5 s 2 U is required for proper decoding of NNR codons in eukaryotes.", "ScPif1p has higher binding ability to G-rich ssDNA than to non-G-rich ssDNA.", "There is no known interaction between Pioneer factor OCT3/4 and major chromatin remodeling factors.", "ScPif1p has reduced binding ability to G-rich ssDNA compared to non-G-rich ssDNA.", "CCL19 is a ligand for CCR7.", "BLM gene encodes RecQ-class DNA helicase."], "hard_negative": "The predominant localization of Linc00173 is in mononuclear macrophage nuclei."}
{"query_id": "1254", "query_text": "The proliferative capacity of neural progenitors differs across species.", "negative": "RA activation of DIF2 and NB4 cells induces hallmarks of transcriptionally active promoters.", "negatives": ["RA activation of DIF2 and NB4 cells induces hallmarks of transcriptionally active promoters.", "Deleting Raptor increases G-CSF levels.", "Chronic HIV stimulation of B cells leads to the premature exhaustion of B cells.", "Antiretroviral therapy increases rates of tuberculosis across a broad range of CD4 strata.", "Headaches are correlated with cognitive impairment.", "Pre-mRNAs associated with spliceosomal components are less stable than unassociated splicing substrates.", "Converting apoE4 to apoE3 by gene editing worsens the pathology associated with apoE4 in human iPSCderived neurons.", "The proportion of people with visual difficulty is two times higher in low-income countries than in high-income countries.", "Removal of H3K9me3 by ectopic expression of other H3K9 demethylases decreases reprogramming efficiency in SCNT experiments.", "The number of unfertilized oocytes in mated hermaphrodites increases with age."], "hard_negatives": ["The proliferative capacity of neural progenitors differs across species.", "The proliferative capacity of progenitors is regulated cell-autonomously.", "Pure neural progenitor cell (NPC) populations can only be obtained from cell cultures that undergo passaging, filtration, or other isolation and cell sorting methods.", "Upregulation of dynein in Drosophila neurons increases the number of microtubule plus-ends growing toward the cell body of each neuron.", "MeCP2 influences the synaptic maturation of neurons.", "Insulin effects appetite via ventral tegmental neurons.", "Human embryonic stem cells have the capacity to give rise to differentiated progeny representative of all three embryonic germ layers.", "Differentiation of progenitor cells to myeloid cells is skewed upon activation of insulin signaling.", "Human embryonic stem cells give rise to cell types from all three embryonic germ layers.", "Hypothalamic glutamate neurotransmission is unrelated to energy balance."], "hard_negative": "The proliferative capacity of neural progenitors differs across species."}
{"query_id": "1255", "query_text": "The proliferative capacity of progenitors is regulated cell-autonomously.", "negative": "Medications to treat obesity have unwanted side effects.", "negatives": ["Medications to treat obesity have unwanted side effects.", "Rapamycin increases the concentration of triacylglycerols in fruit flies.", "Sn is present on mature DCs during inflammation in vivo.", "The DESMOND program demonstrates no significant impact on lifestyles outcomes.", "At least 85% of patients exposed to radiation have activated markers of myofibroblasts.", "The myocardial cell lineage originally develops from cardiac progenitors of exclusively endodermal origin.", "Pediatric SCD patients with vaso-occlusive crisis show increased morphine use after breathing 80 ppm iNO for 4 hours.", "G-CSF increases the expansion and infiltration of MDSCs into tumors.", "RTEL1 interacts with TRF2 through a C4C4 motif", "Rhythmic expression of Cry1 translates directly into a circadian regulation of cAMP signaling in hepatic glucose metabolism."], "hard_negatives": ["The proliferative capacity of progenitors is regulated cell-autonomously.", "The proliferative capacity of neural progenitors differs across species.", "Differentiation of progenitor cells to myeloid cells is skewed upon activation of insulin signaling.", "Differentiation of progenitor cells to myeloid cells is skewed when insulin signaling is suppressed.", "Human embryonic stem cells have the capacity to give rise to differentiated progeny representative of all three embryonic germ layers.", "Cellular differentiation of embryonic stem cells is accompanied by changes in replication timing, transcription and nuclear localization.", "Environmentally-induced senescence is mimicked in disease modeling by adding specific molecules to the culture system.", "The myocardial cell lineage originally develops from cardiac progenitors of exclusively endodermal origin.", "Adult tissue-resident macrophages possess a self-renewing capacity.", "Mitochondria play a major role in apoptosis."], "hard_negative": "The proliferative capacity of progenitors is regulated cell-autonomously."}
{"query_id": "1257", "query_text": "The proportion of people with visual difficulty is two times higher in low-income countries than in high-income countries.", "negative": "Concentrations of SNV and CNV in stem-cell regulatory elements and binding sites of transcription factors in iPSC-lines are distinct from their founding cells.", "negatives": ["Concentrations of SNV and CNV in stem-cell regulatory elements and binding sites of transcription factors in iPSC-lines are distinct from their founding cells.", "eRNAs influence is linked to senescence, aging, and carcinogenesis.", "Women with a lower birth weight are more likely to develop breast cancer later in life.", "Upregulation of dynein in Drosophila neurons increases the number of microtubule plus-ends growing toward the cell body of each neuron.", "DMS3 protein enables Pol V transcription in vivo.", "Formation of N-terminal pyroglutamate by glutamine cyclase (GC) competes with NTAQ1 for Nt-Gln substrates.", "The Snf1 complex regulates carbon and energy metabolism in baker's yeast (Saccharomyces cerevisiae).", "Glycan adaptation is rarely observed in the B-cell repertoire.", "Hypothalamic glutamate neurotransmission is unrelated to energy balance.", "Depletion of nitric oxide is responsible for vasospasm."], "hard_negatives": ["The proportion of people with visual difficulty is two times higher in low-income countries than in high-income countries.", "76-85% of people with severe mental disorder receive no treatment in low and middle income countries.", "For every 1,000 children with cerebral palsy, more than 300 of them are premature or underweight at birth.", "Epidemiological disease burden from noncommunicable diseases is more prevalent in high economic settings.", "53% of perinatal mortality is due to low birth weight.", "Malaria has a high vectorial capacity.", "Asymptomatic visual impairment screening in elderly populations leads to improved vision.", "In the UK, drowning affects boys and girls equally.", "ART substantially reduces infectiveness of HIV-positive people.", "Exercise reduces cancer mortality rates among Chinese citizens."], "hard_negative": "The proportion of people with visual difficulty is two times higher in low-income countries than in high-income countries."}
{"query_id": "1258", "query_text": "The recruitment of Wdr5 to its target loci depends on Kat8.", "negative": "Sequence conservation in gene regulatory regions between species is a high-accuracy predictor of conserved functionality.", "negatives": ["Sequence conservation in gene regulatory regions between species is a high-accuracy predictor of conserved functionality.", "The PRR MDA5 has a C-terminal domain.", "The cytokine receptor which regulates chemotaxis and formation of lymph nodes is involved in production of myeloperoxidase in the left atrium.", "Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes fibrosis.", "Increased flux of microbial products provokes immune responses.", "Persistor cells are one reason for incomplete responses to Tyrosine kinase inhibitor (TKI) therapy in cancer patients.", "Comparative transcriptome analysis identified new platelet proteins with structural features suggesting a role in platelet function.", "During non-homologous end joining, the ligation step is not as tolerant of disrepairs and other distortions when joining 5' of strand breaks as compared to 3' strand breaks.", "Monoclonal antibody targeting of N-cadherin encourages metastasis.", "HbA1c consistently overestimates glycemic control in black individuals with Sickle cell trait (SCT)."], "hard_negatives": ["The recruitment of Wdr5 to its target loci depends on Kat8.", "JMJD6 slows the hydroxylation of C-terminal lysine", "JMJD6 catalyzes the hydroxylation of C-terminal lysine and supresses transcriptional activity.", "Stacking is more stable when a purine is present in the +5 position (C1698).", "The minor G allele of FOXO3 up-regulates IL-10.", "MUC1-C activates the NF-\u03baB p65 signaling pathway by interacting with I\u03baB kinase \u00df.", "C2 works synergistically with A-769662 to activate dephosphorylated AMPK.", "Low expression of miR7a does not repress target genes or exert a biological function in ovaries.", "Removal of H3K9me3 by ectopic expression of other H3K9 demethylases improves reprogramming efficiency in SCNT experiments.", "Activated Cdk5 regulates DNA damage-induced neuronal death."], "hard_negative": "The recruitment of Wdr5 to its target loci depends on Kat8."}
{"query_id": "1260", "query_text": "The relationship between a breast cancer patient's capacity to metabolize tamoxifen and treatment outcome is independent of the patient's genetic make-up.", "negative": "In transgenic mice harboring green florescent protein under the control of the Sox2 promoter, more than 50 percent of the cells with green florescent colocalize with cell proliferation markers.", "negatives": ["In transgenic mice harboring green florescent protein under the control of the Sox2 promoter, more than 50 percent of the cells with green florescent colocalize with cell proliferation markers.", "Ly49Q directs the organization of neutrophil polarization by regulating membrane raft functions.", "Chenodeoxycholic acid treatment decreases brown adipose tissue activity.", "Higher plasma levels of I-carnitine, when associated with trimethylamine N-oxide, are positively correlated with cardiovascular events in humans.", "RTEL1 interacts with TRF2 through a C4C4 motif", "MEK inhibitors are effective treatments in RAS-driven mouse models of cancer.", "Thiopurine active metabolites can be catabolized through dephosphorylation of thioguanine nucleotides.", "The mean suicide rate in women is higher after miscarriage than live birth.", "Omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegans.", "Stiff substrates encourage mesodermal differentiation by degrading beta-catenin in an integrin-dependent manner."], "hard_negatives": ["The relationship between a breast cancer patient's capacity to metabolize tamoxifen and treatment outcome is independent of the patient's genetic make-up.", "A breast cancer patient's capacity to metabolize tamoxifen influences treatment outcome.", "Side effects associated with antidepressants do not represent a mortality risk to postmenopausal women.", "The risk of breast cancer among parous women decreases with placental weight of pregnancies.", "Sildenafil worsens erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.", "Pioglitazone use is significantly associated with an increased risk of pancreatic cancer.", "Pioglitazone use is not associated with an increased risk of prostate cancer.", "Pioglitazone use is significantly associated with an increased risk of prostate cancer.", "Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission.", "Metastatic colorectal cancer treated with a single agent fluoropyrimidines resulted in similar efficacy and better quality of life when compared with oxaliplatin-based chemotherapy in elderly patients."], "hard_negative": "The relationship between a breast cancer patient's capacity to metabolize tamoxifen and treatment outcome is independent of the patient's genetic make-up."}
{"query_id": "1261", "query_text": "The removal of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells.", "negative": "Deltex interacts with eIF3. There is no known interaction between Deltex and elF3", "negatives": ["Deltex interacts with eIF3. There is no known interaction between Deltex and elF3", "A deficiency of vitamin B12 decreases blood levels of homocysteine.", "The amount of publicly available DNA data doubles every 10 months.", "Rapamycin increases the concentration of triacylglycerols in fruit flies.", "Immune responses in immune cells are geographically segregated.", "Mice lacking Sirt1 in Sf1-expressing neurons have increased susceptibility to diet-induced obesity and insulin resistance.", "HAND2 methylation is a key step in early endometrial carcinogenesis.", "Immune complex triggered cell death leads to extracellular release of nuclear DNA.", "The tissue surrounding the granuloma in an immune cell induces an anti-inflammatory immune response.", "DUSP4 increases apoptosis."], "hard_negatives": ["The generation of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells.", "The removal of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells.", "Carriers of HNF4A mutations are at reduced risk for diabetes.", "Ethanol stress lowers the expression of PSP in bacteria.", "There is no association between HNF4A mutations and diabetes risks.", "Low nucleosome occupancy correlates with high methylation levels across species.", "Ethanol stress increases the expression of IBP in bacteria.", "Ethanol stress increases the expression of PSP in bacteria.", "Ethanol stress reduces the expression of SRL in bacteria.", "HNF4A mutations are associated with macrosomia in infancy."], "hard_negative": "The generation of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells."}
{"query_id": "1263", "query_text": "The repeat-variable diresidue (RVD) in the loop of Transcription-Activator Like (TAL) effectors specifies the nucleotides-amino acid contact at the target promoter element.", "negative": "Forkhead 0 (fox0) transcription factors are involved in cellular differentiation.", "negatives": ["Forkhead 0 (fox0) transcription factors are involved in cellular differentiation.", "A deficiency of vitamin B12 decreases blood levels of homocysteine.", "Adult tissue-resident macrophages are seeded before birth.", "Suboptimal nutrition is a leading cause of premature death", "A deficiency of vitamin B6 decreases blood levels of homocysteine.", "Prescribed exercise training improves quality of life.", "Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes epithelial damage.", "Ribosome-inactivating protein-2 (RIP-2) interacts with the p75 NTR death domain", "Improvements in OER catalysts show stable activity over several hundred hours.", "Treatment with the EC uptake inhibitor AM404 resulted in a dose-dependent decrease in the expression of immobility."], "hard_negatives": ["The repeat-variable diresidue (RVD) in the loop of Transcription-Activator Like (TAL) effectors specifies the nucleotides-amino acid contact at the target promoter element.", "Recognition of start codons depends on the translation initiation factor IF3.", "Sequence conservation in gene regulatory regions between species is a high-accuracy predictor of conserved functionality.", "LSD1-positive promoters are associated with RNA polymerase II", "Sequence conservation in gene regulatory regions between species is a poor predictor of conserved functionality.", "mcm 5 s 2 U is required for proper decoding of NNR codons in eukaryotes.", "ITAM phosphorylation allows for the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).", "Genes involved in pre-mRNA splicing have a significant impact on genome stability.", "p75 NTR - associated cell death executor (NADE) interacts with the p75 NTR death domain", "RA activation of DIF2 and NB4 cells induces hallmarks of transcriptionally active promoters."], "hard_negative": "The repeat-variable diresidue (RVD) in the loop of Transcription-Activator Like (TAL) effectors specifies the nucleotides-amino acid contact at the target promoter element."}
{"query_id": "1265", "query_text": "The risk of breast cancer among parous women decreases with placental weight of pregnancies.", "negative": "Bariatric surgery increases rates of postmenopausal breast cancer.", "negatives": ["Bariatric surgery increases rates of postmenopausal breast cancer.", "General exercise therapy is more effective than rotator cuff exercises in reducing pain and improving function of the shoulder.", "The composition of myosin-II isoform switches from the A isoform to the B isoform during hematopoietic differentiation.", "Side effects associated with antidepressants increases risk of stroke.", "The predominant localization of Linc00173 is in mononuclear macrophage nuclei.", "Transcription factor EB induces transcription of pro-inflammatory cytokines in macrophages infected with Staphylococcus aureus.", "90% of patients with melanoma and an objective response to PD-1 blockade will experience a progression in their melanoma.", "Comparative transcriptome analysis identified new platelet proteins with structural features suggesting a role in platelet function.", "Adult tissue-resident macrophages stem from the embryonal yolk sac and fetal liver.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have decreased risk for dementia."], "hard_negatives": ["The risk of breast cancer among parous women decreases with placental weight of pregnancies.", "Women with a lower birth weight are more likely to develop breast cancer later in life.", "Birth-weight is negatively associated with breast cancer.", "The mean suicide rate in women is lower after miscarriage than live birth.", "The mean suicide rate in women is higher after miscarriage than live birth.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have shorter lifetime exposure to estrogen due to a decreased reproductive period.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have longer lifetime exposure to estrogen due to an increased reproductive period.", "Excess gestational weight gain is associated with obesity-related pregnancy outcomes.", "53% of perinatal mortality is due to low birth weight.", "Bariatric surgery increases rates of postmenopausal breast cancer."], "hard_negative": "The risk of breast cancer among parous women decreases with placental weight of pregnancies."}
{"query_id": "1268", "query_text": "The risk of cancer rises with level of alcohol consumption.", "negative": "In pediatric tissue, most T cells are naive T cell emigrants from the thymus.", "negatives": ["In pediatric tissue, most T cells are naive T cell emigrants from the thymus.", "Eliminating the last sporadic cases of malaria requires considerable funding.", "Healthy volunteers exhibit rapid and transient increase of cellular ATP after being bolus-injected with fructose.", "Smc5/6 engagment halts the activation of SUMO E3 ligase Mms21 by ATP-dependent remolding.", "Genomic sequences involved in alternative splicing responsible for Hutchinson-Gilford progeria syndrome (HGPS) are abundant in the ''progerinonly'' allele of Lmna knock-in models.", "The composition of myosin-II isoform switches from the A isoform to the B isoform during hematopoietic differentiation.", "Natriuretic peptides increase susceptibility to diabetes.", "Activated Cdk5 regulates DNA damage-induced neuronal death.", "Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection increases dissemination of Salmonella Typhimurium from the gut.", "Oxidative phosphorylation is one of the primary glycometabolic pathways in cells."], "hard_negatives": ["The risk of cancer rises with level of alcohol consumption.", "Exercise reduces cancer mortality rates among Chinese citizens.", "Exercise increases cancer mortality rates among Chinese citizens.", "Women with a lower birth weight are more likely to develop breast cancer later in life.", "Participants who quit smoking reduce lung cancer risk by approximately 50%.", "The risk of breast cancer among parous women decreases with placental weight of pregnancies.", "Pioglitazone use is significantly associated with an increased risk of pancreatic cancer.", "Taking 400mg of \u03b1-tocopheryl acetate in combination with vitamin C reduces the risk of prostate cancer.", "Pioglitazone use is significantly associated with an increased risk of prostate cancer.", "Environmental factors can influence the development of breast cancer."], "hard_negative": "The risk of cancer rises with level of alcohol consumption."}
{"query_id": "1269", "query_text": "The risk of female prisoners harming themselves is ten times that of male prisoners.", "negative": "AZT given with ribavirin increases anemia.", "negatives": ["AZT given with ribavirin increases anemia.", "F4/80+ macrophages regulate mature osteoblast maintenance.", "Natriuretic peptides increase susceptibility to diabetes.", "Piezo1 channels are sensors for cell migration in epithelial cells.", "Egr3 regulates the homeostasis of B and T cells.", "The density of cytokine receptor bearing cells has no effect on the distance over which cytokines act.", "Charcoal shows no benefit for acute paraquat poisoning.", "Tirasemtiv targets fast-twitch muscle.", "Persistor cells are one reason for incomplete responses to Tyrosine kinase inhibitor (TKI) therapy in cancer patients.", "M. stadtmanae does not induce ASC speck formation in BlaER1 monocytes."], "hard_negatives": ["The risk of female prisoners harming themselves is ten times that of male prisoners.", "The mean suicide rate in women is higher after miscarriage than live birth.", "The mean suicide rate in women is lower after miscarriage than live birth.", "British female students are bullied more than British male students.", "British male students are bullied more than British female students.", "In the UK, drowning affects boys and girls equally.", "Chlamydia trachomatis is most prevalent in the UK among sexually-experienced individuals aged 16 to 24.", "Sildenafil worsens erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.", "Women are more susceptible to death due to pneumonia when compared to men.", "10% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months."], "hard_negative": "The risk of female prisoners harming themselves is ten times that of male prisoners."}
{"query_id": "1275", "query_text": "The tip of the inner tube of the toxic type VI secretion system (T6SS) antibacterial effector in Escherichia coli (E. coli) is decorated with VgrG and PAAR proteins.", "negative": "90% of patients with melanoma and an objective response to PD-1 blockade will experience a progression in their melanoma.", "negatives": ["90% of patients with melanoma and an objective response to PD-1 blockade will experience a progression in their melanoma.", "Normal expression of RUNX1 causes tumorsupressing effects.", "The G34R/V mutation does not create a hypomethylated phenotype at the H3K36 histone.", "Forkhead 0 (fox0) transcription factors are involved in cellular differentiation.", "Tumor development occurs in conjunction with suppression of pro-inflammatory cytokines.", "Whole brain radiotherapy increases the occurrence of new brain metastases.", "Lmna knock-in models are appropriate for testing therapeutic approaches against Hutchinson-Gilford progeria syndrome (HGPS).", "The DESMOND program demonstrates no significant impact on lifestyles outcomes.", "The mean suicide rate in women is higher after miscarriage than live birth.", "Tonic signaling from the scFv prevents constitutive stimulation."], "hard_negatives": ["The tip of the inner tube of the toxic type VI secretion system (T6SS) antibacterial effector in Escherichia coli (E. coli) is decorated with VgrG and PAAR proteins.", "VgrG (Tssl) protein punctures membranes by forming a spike at the tip of the tube apparatus.", "During the primary early antibody response activated B cells migrate toward the inner-and outer follicular areas where oxysterol accumulation is generated by stromal cells.", "Eilat virus (EILV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in nonhuman primates.", "Citrullinated proteins externalized in neutrophil extracellular traps act indirectly to perpetuate the inflammatory cycle via induction of autoantibodies.", "Nonhuman primates are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.", "Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection increases dissemination of Salmonella Typhimurium from the gut.", "Active H. pylori urease has a polymeric structure consisting of five distinct subunits.", "\u03b2-sheet opening occurs during pleurotolysin pore formation.", "The C-type lectin receptor (CLEC-2) rearranges the actin cytoskeleton in dendritic cells to promote efficient motility along stromal surfaces."], "hard_negative": "The tip of the inner tube of the toxic type VI secretion system (T6SS) antibacterial effector in Escherichia coli (E. coli) is decorated with VgrG and PAAR proteins."}
{"query_id": "1276", "query_text": "The tissue surrounding the granuloma in an immune cell induces an anti-inflammatory immune response.", "negative": "Neutrophil extracellular trap (NET) antigens may contain the targeted autoantigens PR3 and MPO.", "negatives": ["Neutrophil extracellular trap (NET) antigens may contain the targeted autoantigens PR3 and MPO.", "Lack of FGF21 in mice leads to reduced lifespan.", "Students who perform poorly in the early years of medical school are less likely to commit professional misconduct later in their careers.", "r-protein chaperones are found in complexes with their r-protein binding partners.", "PD-1 triggering on monocytes enhances IL-10 production by monocytes.", "Insulin decreases risk of severe kidney failure.", "Bariatric surgery leads to negative outcomes in mental health.", "Removal of H3K9me3 improves reprogramming efficiency in human somatic cell nuclear transfer experiments.", "Ethanol stress reduces the expression of SRL in bacteria.", "Microcin J25 encourages nucleoside triphosphate (NTP) binding."], "hard_negatives": ["The tissue surrounding the granuloma in an immune cell induces an anti-inflammatory immune response.", "Tuberculosis-induced granulomas express different immune system protein signatures than the surrounding tissue.", "Inhibiting focal adhesion formation increases the rate at which cells convert mechanical strain into inflammation and fibrosis.", "Cancer cells can stimulate the accumulation of intra-tumoural myeloid-derived suppressor cells by promoting granulocyte colony stimulating factor production.", "Normal granulomas form in the presence of TNF in Zebrafish.", "Normal granulomas form in the absence of TNF in Zebrafish.", "Cancer-associated fibroblasts (CAFs) interact with cancer cells to mediate formation and activation of CAFs.", "Cancer-associated fibroblasts (CAFs) have no known interaction with cancer cells in the formation and activation of CAFs.", "Cancer-associated fibroblasts (CAFs) are constituents of tumor microenvironments", "Increased flux of microbial products provokes immune responses."], "hard_negative": "The tissue surrounding the granuloma in an immune cell induces an anti-inflammatory immune response."}
{"query_id": "1284", "query_text": "Therapeutics receiving accelerated approval encounter a lower frequency of post-marketing safety events", "negative": "CCL19 is a ligand for CCR7.", "negatives": ["CCL19 is a ligand for CCR7.", "Cholesterol loading induces KLF4 expression in VSMCs, resulting in the expression of pro-inflammatory cytokines.", "Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection decreases dissemination of Salmonella Typhimurium from the gut.", "Diabetic patients with acute coronary syndrome experience decreased short-term and long-term risk for bleeding events.", "Cardiac tissue-resident macrophages directly contribute to electrical activity.", "Individuals with Alzheimers who participate in six months of physical activity improve cognitive function for up to 18 months.", "Charcoal shows no benefit for acute paraquat poisoning.", "Reduction of purity of cytoplasmic membranes isolated from overexpressors is indicated by stronger spots for OmpA in 2D BN-PAGE gels.", "Adult tissue-resident macrophages possess a self-renewing capacity.", "Sympathetic nerve activity is elevated throughout normal pregnancy."], "hard_negatives": ["Therapeutics receiving accelerated approval encounter a lower frequency of post-marketing safety events", "The most prevalent adverse events to Semaglutide are cardiovascular.", "Side effects associated with antidepressants increases risk of stroke.", "Side effects associated with antidepressants do not represent a mortality risk to postmenopausal women.", "Taking anti-depresents is associated with a decrease in the A\u03b2 level in the brain of experimental animals.", "Including pharmacists in rounding teams does not alter the incidence of adverse drug events (ADEs).", "Assessing treatment adherence is more beneficial to clinical practice than measuring routine outcomes.", "Side effects associated with antidepressants lower risk of myocardial infarction.", "Including pharmacists in rounding teams reduces the incidence of adverse drug events (ADEs).", "Stroke patients with prior use of direct oral anticoagulants have a higher risk of in-hospital mortality than stroke patients with prior use of warfarin."], "hard_negative": "Therapeutics receiving accelerated approval encounter a lower frequency of post-marketing safety events"}
{"query_id": "1288", "query_text": "There is a positive correlation between hip fractures and statin use.", "negative": "The appearance of brown-like or beige cells primarily occurs in visceral fat, not subcutaneous fat.", "negatives": ["The appearance of brown-like or beige cells primarily occurs in visceral fat, not subcutaneous fat.", "Immune complex triggered cell death leads to extracellular release of nuclear DNA.", "ITAM phosphorylation allows for the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).", "90% of patients with melanoma and an objective response to PD-1 blockade will experience a progression in their melanoma.", "Omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegans.", "Cancer-associated fibroblasts (CAFs) are constituents of tumor microenvironments", "Osteocytes have an essential role in G-CSF induced HSPC mobilization.", "Primary pro-inflammatory cytokines suppress secondary pro- and anti-inflammatory mediators.", "Anthrax spores are very difficult to dispose once they are dispersed.", "Noninvasive positive pressure ventilation is not predictive of acute respiratory failure after solid organ transplantation."], "hard_negatives": ["There is a positive correlation between hip fractures and statin use.", "The peak incidence of fractures occurs in toddlers.", "Surgical treatment is not superior to non-surgical in treating adults with displaced fractures of the proximal humerus.", "The peak incidence of fractures occurs during pubertal growth spurt in early adolescents.", "Scapular stabilizer exercises are more effective than general exercise therapy in reducing pain and improving function of the shoulder.", "Rotator cuff exercises are more effective than general exercise therapy in reducing pain and improving function of the shoulder.", "General exercise therapy is more effective than scapular stabilizer exercises in reducing pain and improving function of the shoulder.", "General exercise therapy is more effective than rotator cuff exercises in reducing pain and improving function of the shoulder.", "Sildenafil worsens erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.", "Diabetes remission occurs less in people treated with conventional therapy than in people treated with laparoscopic adjustable gastric banding surgery."], "hard_negative": "There is a positive correlation between hip fractures and statin use."}
{"query_id": "1289", "query_text": "There is a relation between Erythromycin use and hypertrophic pyloric stenosis.", "negative": "Tirasemtiv targets fast-twitch muscle.", "negatives": ["Tirasemtiv targets fast-twitch muscle.", "Bcp1 is a chaperone for Rpl23.", "Weighed food records (WFR) result in poor completion since they're costly to run and impose high participant burden.", "Tirasemtiv has no effect on cardiac muscle.", "Removal of H3K9me3 improves reprogramming efficiency in human somatic cell nuclear transfer experiments.", "Headaches are correlated with cognitive impairment.", "Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes epithelial damage.", "Myelin sheaths are lipid-rich cellular structures.", "A 100g dose of chloroquine chemoprophylactic regimen results in retinal toxicity after 5-6 years of weekly intake.", "Bariatric surgery leads to negative outcomes in mental health."], "hard_negatives": ["There is a relation between Erythromycin use and hypertrophic pyloric stenosis.", "There is no relation between Erythromycin use and hypertrophic pyloric stenosis.", "The most prevalent adverse events to Semaglutide are gastrointestinal.", "There is no increased risk of hypospadias with clomiphene.", "Varenicline monotherapy is more effective after 26 weeks of treatment compared to combination nicotine replacement therapies with varenicline or bupropion.", "The most prevalent adverse events to Semaglutide are cardiovascular.", "Combination nicotine replacement therapies with varenicline or bupropion are more effective after 12 weeks of reatment compared to varenicline monotherapy.", "Side effects associated with antidepressants increases risk of stroke.", "Sildenafil worsens erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.", "Diabetes remission occurs more in people treated with conventional therapy than in people treated with laparoscopic adjustable gastric banding surgery."], "hard_negative": "There is a relation between Erythromycin use and hypertrophic pyloric stenosis."}
{"query_id": "1291", "query_text": "There is no association between HNF4A mutations and diabetes risks.", "negative": "MEK inhibitors are effective treatments in RAS-driven mouse models of cancer.", "negatives": ["MEK inhibitors are effective treatments in RAS-driven mouse models of cancer.", "A low percentage of hematopoietic progenitor cells are susceptible to HIV-1 infection ex vivo.", "Side effects associated with antidepressants do not represent a mortality risk to postmenopausal women.", "BiP is a general endoplasmic reticulum stress marker.", "Obesity decreases life quality.", "HbA1c consistently overestimates glycemic control in black individuals with Sickle cell trait (SCT).", "Reducing H3k4me3 methylation induces mouse epiblast stem cells to naive pluripotency efficiently.", "Surgical treatment is not superior to non-surgical in treating adults with displaced fractures of the proximal humerus.", "A high microerythrocyte count protects against severe anemia in homozygous alpha (+)- thalassemia trait subjects.", "Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission."], "hard_negatives": ["There is no association between HNF4A mutations and diabetes risks.", "Carriers of HNF4A mutations are at reduced risk for diabetes.", "A mutation in HNF4A leads to an increased risk of developing diabetes by the age of 14 years.", "HNF4A mutations are associated with macrosomia in infancy.", "A mutation in HNF4A leads to an increased risk of diabetes by the age of 14 years.", "A deficiency of vitamin B12 decreases blood levels of homocysteine.", "The generation of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells.", "In patients with congenital heart defects, \u03b2-blockers significantly improve clinical heart failure outcomes.", "Autophagy deficiency in the liver increases vulnerability to insulin resistance.", "Gpr124 increases BBB breakdown in mouse models of ischemic stroke."], "hard_negative": "There is no association between HNF4A mutations and diabetes risks."}
{"query_id": "1293", "query_text": "There is no increased risk of hypospadias with clomiphene.", "negative": "HSCT-T dosage may not be diagnostic if the onset of symptoms occurs less than 3 hours before AMI.", "negatives": ["HSCT-T dosage may not be diagnostic if the onset of symptoms occurs less than 3 hours before AMI.", "Autologous transplantation of mesenchymal stem cells has better graft function than induction therapy with anti-interleukin-2 receptor antibodies.", "In S. cerevisiae, the absence of RNA surveillance pathways causes sensitivity to high iron conditions.", "COPI coatmer is involved in lipid homeostasis.", "MeCP2 influences the synaptic maturation of neurons.", "Self-advocacy training is effective at decreasing homelessness.", "Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 inhibit West Nile virus replication in cortical neurons.", "Monoclonal antibody targeting of N-cadherin inhibits castration resistance.", "Ly6C hi monocytes have a higher inflammatory capacity than Ly6C lo monocytes.", "Many cytokines that are produced by cancer cells also contribute to carcinogenesis."], "hard_negatives": ["There is no increased risk of hypospadias with clomiphene.", "The most prevalent adverse events to Semaglutide are cardiovascular.", "The most prevalent adverse events to Semaglutide are gastrointestinal.", "Dexamethasone increases risk of postoperative bleeding.", "Sildenafil worsens erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.", "Varenicline monotherapy is more effective after 26 weeks of treatment compared to combination nicotine replacement therapies with varenicline or bupropion.", "Higher plasma levels of I-carnitine, when associated with trimethylamine N-oxide, are negatively correlated with cardiovascular events in humans.", "Higher plasma levels of I-carnitine, when associated with trimethylamine N-oxide, are positively correlated with cardiovascular events in humans.", "Side effects associated with antidepressants lower risk of myocardial infarction.", "Pioglitazone use is significantly associated with an increased risk of pancreatic cancer."], "hard_negative": "There is no increased risk of hypospadias with clomiphene."}
{"query_id": "1294", "query_text": "There is no known interaction between Pioneer factor OCT3/4 and major chromatin remodeling factors.", "negative": "Pro-inflammatory cytokines are up regulated during tumor development.", "negatives": ["Pro-inflammatory cytokines are up regulated during tumor development.", "The peak incidence of fractures occurs during pubertal growth spurt in early adolescents.", "Up-regulation of the p53 pathway and related molecular events speeds cancer progression.", "MUC1-C activates the NF-\u03baB p65 signaling pathway by interacting with I\u03baB kinase \u00df.", "0-dimensional biomaterials lack inductive properties.", "C2 works synergistically with A-769662 to activate dephosphorylated AMPK.", "MafA phosphorylation decreases its ubiquitination.", "There is a positive correlation between hip fractures and statin use.", "The myocardial cell lineage originally develops from cardiac progenitors of exclusively endodermal origin.", "The mean suicide rate in women is lower after miscarriage than live birth."], "hard_negatives": ["There is no known interaction between Pioneer factor OCT3/4 and major chromatin remodeling factors.", "Pioneer factor OCT3/4 interacts with major chromatin remodeling factors.", "The predominant localization of Linc00173 is in mononuclear macrophage nuclei.", "Bcp1 is a chaperone for Rpl23.", "CD44v6 is not associated with constitutive and reprogrammed cancer stem cells driving cancer metastasis.", "CDK6 shows impaired binding to loss-of-function variants of p18 INK4C.", "The PPR MDA5 has twenty N-terminal CARD domains.", "CDK6 shows improved binding to loss-of-function variants of p18 INK4C.", "Addition of BMP4, activin A, CHIR99021, and SU504 to reprogramming fibroblasts generates, expands and maintains cardiovascular progenitor cells (CPCs)", "Replacement of OCT4 and SOX2 genes with GATA3 has the ability to reprogram human cells."], "hard_negative": "There is no known interaction between Pioneer factor OCT3/4 and major chromatin remodeling factors."}
{"query_id": "1295", "query_text": "There is no relation between Erythromycin use and hypertrophic pyloric stenosis.", "negative": "Decreased conversion of PGE 2 to PPARy ligand 15-ket-PGE 2 causes accumulation of PGE.", "negatives": ["Decreased conversion of PGE 2 to PPARy ligand 15-ket-PGE 2 causes accumulation of PGE.", "Medications to treat obesity are highly effective.", "Diabetes remission occurs more in people treated with conventional therapy than in people treated with laparoscopic adjustable gastric banding surgery.", "Kir7.1 modulates channel activity by the G protein-coupled melanocortin-4 receptor (MC4R) in the paraventricular nucleus of the hypothalamus.", "Over half of the gabonese children with Schimmelpenning-Feuerstein-Mims syndrome (SFM) had a plasma lactate of more than 5mmol/L.", "Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission.", "Distant CREs are less conserved among species.", "Induction of urokinase receptor signaling in podocytes causes foot process effacement and proteinuria.", "The recruitment of Wdr5 to its target loci depends on Kat8.", "Induced hepatic stem cells possess the potential to differentiate into hepatocytic cells."], "hard_negatives": ["There is no relation between Erythromycin use and hypertrophic pyloric stenosis.", "There is a relation between Erythromycin use and hypertrophic pyloric stenosis.", "There is no increased risk of hypospadias with clomiphene.", "The most prevalent adverse events to Semaglutide are gastrointestinal.", "Varenicline monotherapy is more effective after 26 weeks of treatment compared to combination nicotine replacement therapies with varenicline or bupropion.", "The most prevalent adverse events to Semaglutide are cardiovascular.", "Combination nicotine replacement therapies with varenicline or bupropion are more effective after 12 weeks of reatment compared to varenicline monotherapy.", "Diabetes remission occurs less in people treated with conventional therapy than in people treated with laparoscopic adjustable gastric banding surgery.", "Diabetes remission occurs more in people treated with conventional therapy than in people treated with laparoscopic adjustable gastric banding surgery.", "Sildenafil worsens erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants."], "hard_negative": "There is no relation between Erythromycin use and hypertrophic pyloric stenosis."}
{"query_id": "1297", "query_text": "There was an estimated 30 million cases of pneumonia in young children worldwide in 2010.", "negative": "IFIT1 speeds viral replication by allowing for the proliferation of mis-capped viral RNAs.", "negatives": ["IFIT1 speeds viral replication by allowing for the proliferation of mis-capped viral RNAs.", "Pyridostatin prevents double-strand breaks accumulation.", "The latent infection of myeloid cells with human cytomegalovirus induces a number of changes in gene expression.", "Nonhuman primates are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.", "Flexible molecules experience less steric hindrance in the tumor microenviroment than rigid molecules.", "Primary cervical cytology screening with HPV detection has higher longitudinal sensitivity to detect severe cervical intraepithelial neoplasia than conventional cytology.", "DUSP4 decreases apoptosis.", "Gastric infection with Helicobacter pylori increases risk of gastric cancer in humans.", "Mutations in RIM1 raise levels of IME1 RNA.", "GATA3 regulates cell cycle progression in bone marrow hematopoietic stem cells."], "hard_negatives": ["There was an estimated 30 million cases of pneumonia in young children worldwide in 2010.", "10% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.", "90% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.", "Women are more susceptible to death due to pneumonia when compared to men.", "Men are more susceptible to death due to pneumonia when compared to women.", "Rising temperatures caused by global warming increases risk of dengue fever transmission.", "Rising temperatures caused by global warming lowers the risk of dengue fever transmission.", "Sepsis related mortality has risen from 2009 to 2014.", "Tuberculosis incidence occurs at higher rates in more sparsely populated areas in the UK.", "Approximately 250,000 people are infected with human T-cell lymphotropic virus type 1 in the United Kingdom."], "hard_negative": "There was an estimated 30 million cases of pneumonia in young children worldwide in 2010."}
{"query_id": "1300", "query_text": "Thiopurine active metabolites can be catabolized through dephosphorylation of thioguanine nucleotides.", "negative": "Varying expression levels of EBI2 affect the positioning and migration of B cells.", "negatives": ["Varying expression levels of EBI2 affect the positioning and migration of B cells.", "Sequence conservation in gene regulatory regions between species is a high-accuracy predictor of conserved functionality.", "MFGE8 regulates fat absorption by binding to av-Beta3 and av-Beta5 integrins.", "The risk of cancer rises with level of alcohol consumption.", "B3-Galectin decreases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR.", "ScPif1p has higher binding ability to G-rich ssDNA than to non-G-rich ssDNA.", "Women with a lower birth weight are more likely to develop breast cancer later in life.", "ATM and Rad3 related protein have no role in sensing DNA damage.", "H4 G94P proteins inhibit chromatin assembly, which decreases free histones.", "ATM and Rad3 related protein are critical for sensing DNA damage."], "hard_negatives": ["Thiopurine active metabolites can be catabolized through dephosphorylation of thioguanine nucleotides.", "Higher plasma levels of I-carnitine, when associated with trimethylamine N-oxide, are positively correlated with cardiovascular events in humans.", "Higher plasma levels of I-carnitine, when associated with trimethylamine N-oxide, are negatively correlated with cardiovascular events in humans.", "A breast cancer patient's capacity to metabolize tamoxifen influences treatment outcome.", "Omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegetarians.", "Omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegans.", "The relationship between a breast cancer patient's capacity to metabolize tamoxifen and treatment outcome is independent of the patient's genetic make-up.", "Active H. pylori urease has a polymeric structure consisting of five distinct subunits.", "N348I mutations reduce resistance to nevirapine.", "Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission."], "hard_negative": "Thiopurine active metabolites can be catabolized through dephosphorylation of thioguanine nucleotides."}
{"query_id": "1302", "query_text": "Tirasemtiv has no effect on cardiac muscle.", "negative": "The PRDM1 gene is a key determinant of primordial germ cells.", "negatives": ["The PRDM1 gene is a key determinant of primordial germ cells.", "The proliferative capacity of progenitors is regulated cell-autonomously.", "Whole brain radiotherapy increases the occurrence of new brain metastases.", "Chronic HIV stimulation of B cells leads to the premature exhaustion of B cells.", "One in two surgical randomized controlled trials are discontinued early.", "MFGE8 regulates fat absorption by binding to av-Beta3 and av-Beta5 integrins.", "Patients with common epithelial cancers are less likely to have an emergency event as their first hospital admission if they live in resource-deprived areas.", "Mitochondria play a trivial role in calcium homeostasis.", "The proliferative capacity of progenitors is regulated cell-autonomously.", "Klf4 is not required for proper myeloid cell differentiation."], "hard_negatives": ["Tirasemtiv has no effect on cardiac muscle.", "Tirasemtiv targets cardiac muscle.", "Tirasemtiv targets fast-twitch muscle.", "EGR2 is important to myelination of the peripheral nervous system.", "Cardiac tissue-resident macrophages directly contribute to electrical activity.", "Sudden death can occur in patients with orthostatic hypertension without cardiac conduction abnormalities.", "Mice lacking Sirt1 in Sf1-expressing neurons have increased susceptibility to diet-induced obesity and insulin resistance.", "Mice lacking Sirt1 in Sf1-expressing neurons are immune to diet-induced obesity and insulin resistance.", "HSCT-T dosage may not be diagnostic if the onset of symptoms occurs less than 3 hours before AMI.", "Egr2 regulates the homeostasis of B and T cells."], "hard_negative": "Tirasemtiv has no effect on cardiac muscle."}
{"query_id": "1304", "query_text": "Tirasemtiv targets cardiac muscle.", "negative": "Early patent ductus ateriosus (PDA) screening increases in-hospital mortality.", "negatives": ["Early patent ductus ateriosus (PDA) screening increases in-hospital mortality.", "The HSV-2 infection is typically asymptomatic.", "Ethanol stress increases the expression of IBP in bacteria.", "Misunderstandings between doctors and patients can lead to non-adherence.", "Converting apoE4 to apoE3 by gene editing worsens the pathology associated with apoE4 in human iPSCderived neurons.", "Gpr124 suppresses BBB breakdown in mouse models of ischemic stroke.", "The risk of female prisoners harming themselves is ten times that of male prisoners.", "PCSK9 inhibitors decrease plasma Lp(a) levels.", "Human embryonic stem cells give rise to cell types from all three embryonic germ layers.", "Mice lacking Sirt1 in Sf1-expressing neurons are immune to diet-induced obesity and insulin resistance."], "hard_negatives": ["Tirasemtiv targets cardiac muscle.", "Tirasemtiv targets fast-twitch muscle.", "Tirasemtiv has no effect on cardiac muscle.", "EGR2 is important to myelination of the peripheral nervous system.", "Cardiac tissue-resident macrophages directly contribute to electrical activity.", "Egr2 regulates the homeostasis of B and T cells.", "Egr3 regulates the homeostasis of B and T cells.", "CD28 signals regulate trafficking of murine auto-reactive T cells into target tissues.", "Major antigen-induced signals from the T cell receptor and secondary signals from costimulatory receptors are required for T cell activation.", "HIV trans-activator protein (TAT) effectively transports large and small molecules across cellular membranes into larger populations of neurons."], "hard_negative": "Tirasemtiv targets cardiac muscle."}
{"query_id": "1305", "query_text": "Tirasemtiv targets fast-twitch muscle.", "negative": "Traditional reviews are biased in their interpretations.", "negatives": ["Traditional reviews are biased in their interpretations.", "Upregulation of dynein in Drosophila neurons increases the number of microtubule plus-ends growing toward the cell body of each neuron.", "Incidence of 10/66 dementia is higher than the incidence of DSM-IV dementia.", "Chinese individuals with TT homozygosity in the MTHFR gene are more vulnerable to strokes caused by low levels of folate intake.", "Birth-weight is negatively associated with breast cancer.", "siRNA knockdown of A20 slows tumor progression in an in vivo murine xenograft model.", "The risk of cancer rises with level of alcohol consumption.", "A diminished ovarian reserve does not solely indicate infertility in an a priori non-infertile population.", "Long chain polyunsaturated fatty acids supplementation reduces wheezing and asthma.", "Gastric lavage is an effective treatment for acute paraquat poisoning."], "hard_negatives": ["Tirasemtiv targets fast-twitch muscle.", "Tirasemtiv targets cardiac muscle.", "Tirasemtiv has no effect on cardiac muscle.", "EGR2 is important to myelination of the peripheral nervous system.", "CD28 signals regulate trafficking of murine auto-reactive T cells into target tissues.", "HIV trans-activator protein (TAT) effectively transports large and small molecules across cellular membranes into larger populations of neurons.", "Major antigen-induced signals from the T cell receptor and secondary signals from costimulatory receptors are required for T cell activation.", "IFI16 impedes STING phosphorylation and translocation, resulting in reduced activation of STING.", "Foxk2 regulates autophagy genes in muscle cells and fibroblast cells.", "Mice lacking Sirt1 in Sf1-expressing neurons have increased susceptibility to diet-induced obesity and insulin resistance."], "hard_negative": "Tirasemtiv targets fast-twitch muscle."}
{"query_id": "1306", "query_text": "Toll-like receptor (TLR) signaling is involved in the pathogenesis of human MDS.", "negative": "Higher plasma levels of I-carnitine, when associated with trimethylamine N-oxide, are positively correlated with cardiovascular events in humans.", "negatives": ["Higher plasma levels of I-carnitine, when associated with trimethylamine N-oxide, are positively correlated with cardiovascular events in humans.", "Deletion of ATM and Rad3 related protein leads to acute tissue loss.", "Pyridostatin induces double-strand breaks accumulation.", "GATA3 regulates self-renewal capacity in bone marrow hematopoietic stem cells.", "IL-6 signaling plays a major role in atherosclerotic cardiovascular disease.", "RAD52 is involved in break-induced DNA replication (BIR).", "Primary cervical cancer screening with HPV detection has lower longitudinal sensitivity than conventional cytology to detect cervical intraepithelial neoplasia grade 2.", "Human embryonic stem cells have the capacity to give rise to differentiated progeny representative of all three embryonic germ layers.", "0-dimensional biomaterials lack inductive properties.", "Gpr124 suppresses BBB breakdown in mouse models of ischemic stroke."], "hard_negatives": ["Toll-like receptor (TLR) signaling is involved in the pathogenesis of human MDS.", "Certain immunomodulator-human dialyzable leukocyte extract (hDLE) peptides are recognized by toll-like receptors (TLRs) on macrophages and dendritic cells.", "The PPR MDA5 has twenty N-terminal CARD domains.", "The PRR MDA5 has a C-terminal domain.", "Activated Cdk5 phosphorylates the ATM protein in response to DNA damage.", "CD28 signals regulate trafficking of murine auto-reactive T cells into target tissues.", "Gpr124 suppresses BBB breakdown in mouse models of ischemic stroke.", "IL-6 signaling plays a major role in atherosclerotic cardiovascular disease.", "Dscam1 acts as a hypervariable pattern-recognition receptor for the immune system.", "Gpr124 increases BBB breakdown in mouse models of ischemic stroke."], "hard_negative": "Toll-like receptor (TLR) signaling is involved in the pathogenesis of human MDS."}
{"query_id": "1307", "query_text": "Tonic signaling from the scFv induces constitutive stimulation.", "negative": "Pro-inflammatory cytokines are up regulated during tumor development.", "negatives": ["Pro-inflammatory cytokines are up regulated during tumor development.", "Tonic signaling from the scFv is amplified by MyD88/CD40.", "Glycan adaptation is rarely observed in the B-cell repertoire.", "Distant CREs are important for transcriptional regulation.", "The cytokine receptor which regulates chemotaxis and formation of lymph nodes is involved in production of myeloperoxidase in the left atrium.", "Forkhead 0 (fox0) transcription factors are involved in cellular differentiation.", "Taking 400mg of \u03b1-tocopheryl acetate in combination with vitamin C reduces the risk of prostate cancer.", "Tuberculosis-induced granulomas express different immune system protein signatures than the surrounding tissue.", "Incidence of heart failure increased by 10% in women since 1979.", "Upon viral challenge, influenza-specific memory CD4+ T cells greatly diminish the early production of inflammatory chemokines in the lung."], "hard_negatives": ["Tonic signaling from the scFv induces constitutive stimulation.", "Tonic signaling from the scFv prevents constitutive stimulation.", "Tonic signaling from the scFv is amplified by MyD88/CD40.", "cSMAC formation represses weak ligand signalling.", "Glial calcium waves influence seizures.", "Inhibiting focal adhesion formation increases the rate at which cells convert mechanical strain into inflammation and fibrosis.", "CD28 initiates tonic signaling in conventional T cells, which causes an exhaustion phenotype and limited efficiency.", "Deleting Raptor increases G-CSF levels.", "Ca2+ cycling is a UCP1-dependent thermogenic mechanism.", "Guanine nucleotide exchange factors (GEFs) mediate RhoA activation in response to tensional forces on fibronectin-binding integrins."], "hard_negative": "Tonic signaling from the scFv induces constitutive stimulation."}
{"query_id": "1308", "query_text": "Tonic signaling from the scFv is amplified by MyD88/CD40.", "negative": "Sildenafil worsens erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.", "negatives": ["Sildenafil worsens erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.", "There is no increased risk of hypospadias with clomiphene.", "C2 works synergistically with A-769662 to activate dephosphorylated AMPK.", "Low expression of miR7a does not repress target genes or exert a biological function in testis.", "Inhibiting HDAC6 increases survival of mice with ARID1A mutated tumors.", "Induction of urokinase receptor signaling in podocytes causes foot process effacement and proteinuria.", "Destination container port throughput(CPT) is negatively related to dengue virus (DENV-1) diffusion in air traffic shipments.", "Environmentally-induced senescence is mimicked in disease modeling by adding specific molecules to the culture system.", "M. stadtmanae does not induce ASC speck formation in BlaER1 monocytes.", "Helminths interfere with immune system control of coinfections by microbial pathogens 16."], "hard_negatives": ["Tonic signaling from the scFv is amplified by MyD88/CD40.", "Tonic signaling from the scFv induces constitutive stimulation.", "Tonic signaling from the scFv prevents constitutive stimulation.", "CD28 initiates tonic signaling in conventional T cells, which causes an exhaustion phenotype and limited efficiency.", "cSMAC formation represses weak ligand signalling.", "CD28 signals regulate trafficking of murine auto-reactive T cells into target tissues.", "Activated Cdk5 regulates DNA damage-induced neuronal death.", "Expression of MSX2 is induced 3 hours after the addition of BMP4, which is earlier than T and CDX2.", "Gpr124 suppresses BBB breakdown in mouse models of ischemic stroke.", "Deleting Raptor increases G-CSF levels."], "hard_negative": "Tonic signaling from the scFv is amplified by MyD88/CD40."}
{"query_id": "1309", "query_text": "Tonic signaling from the scFv prevents constitutive stimulation.", "negative": "L3MBTL2 binds to H2AK119Ub marked chromatin to form a PRC1 complex.", "negatives": ["L3MBTL2 binds to H2AK119Ub marked chromatin to form a PRC1 complex.", "Localization of PIN1 in the roots of Arabidopsis requires VPS9a", "There is no known interaction between Pioneer factor OCT3/4 and major chromatin remodeling factors.", "There is a positive correlation between hip fractures and statin use.", "Early patent ductus ateriosus (PDA) screening increases in-hospital mortality.", "Concentrations of SNV and CNV in stem-cell regulatory elements and binding sites of transcription factors in iPSC-lines are distinct from their founding cells.", "General exercise therapy is more effective than rotator cuff exercises in reducing pain and improving function of the shoulder.", "Glycan adaptation is rarely observed in the B-cell repertoire.", "Taking anti-depresents is associated with a decrease in the A\u03b2 level in the brain of experimental animals.", "HNF4A mutations are associated with macrosomia in infancy."], "hard_negatives": ["Tonic signaling from the scFv prevents constitutive stimulation.", "Tonic signaling from the scFv induces constitutive stimulation.", "Tonic signaling from the scFv is amplified by MyD88/CD40.", "cSMAC formation represses weak ligand signalling.", "CD28 initiates tonic signaling in conventional T cells, which causes an exhaustion phenotype and limited efficiency.", "Inhibiting focal adhesion formation increases the rate at which cells convert mechanical strain into inflammation and fibrosis.", "Glial calcium waves influence seizures.", "Deleting Raptor increases G-CSF levels.", "Inhibiting focal adhesion formation enables cells to convert mechanical strain into eventual scarring.", "Allogeneic mechanical circulatory support is not as effective as autologous mechanical circulatory support for treating acute myocardial infarction."], "hard_negative": "Tonic signaling from the scFv prevents constitutive stimulation."}
{"query_id": "1310", "query_text": "Traditional reviews are biased in their interpretations.", "negative": "Autologous transplantation of mesenchymal stem cells has better graft function than induction therapy with anti-interleukin-2 receptor antibodies.", "negatives": ["Autologous transplantation of mesenchymal stem cells has better graft function than induction therapy with anti-interleukin-2 receptor antibodies.", "Genes involved in pre-mRNA splicing have a significant impact on genome stability.", "Omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegans.", "Treatment with a protein named FN impairs regenerative abilities of aged muscles.", "PrimPol generates short DNA replication intermediates on the leading strand during DNA replication.", "Varying expression levels of EBI2 affect the positioning and migration of B cells.", "Activator-inhibitor pairs are provided ventrally by Xrl-sizzled.", "Medications to treat obesity have unwanted side effects.", "Differentiation of progenitor cells to myeloid cells is skewed upon activation of insulin signaling.", "H4 G94P proteins suppress degradation of free histones via Rad53-dependent mechanisms."], "hard_negatives": ["Traditional reviews are biased in their interpretations.", "Misunderstandings between doctors and patients can lead to non-adherence.", "Assessing treatment adherence is more beneficial to clinical practice than measuring routine outcomes.", "Cost effectiveness evaluations based on cRCT data lack external validity.", "Measuring routine outcomes is more beneficial to clinical practice than assessing treatment adherence.", "Students who perform poorly in the early years of medical school are less likely to commit professional misconduct later in their careers.", "Students who perform poorly in the early years of medical school are at increased risk for professional misconduct later in their careers.", "Cost effectiveness evaluations based on cRCT data accurately reflect prices for patients in actual clinical practice.", "Weighed food records (WFR) result in poor completion since they're costly to run and impose high participant burden.", "British male students are bullied more than British female students."], "hard_negative": "Traditional reviews are biased in their interpretations."}
{"query_id": "1311", "query_text": "Trans-acting factors, such as lncRNAs, influence mRNA translation.", "negative": "Radioiodine treatment of non-toxic multinodular goitre increases thyroid volume.", "negatives": ["Radioiodine treatment of non-toxic multinodular goitre increases thyroid volume.", "The peak incidence of fractures occurs during pubertal growth spurt in early adolescents.", "Taxation of sugar-sweetened beverages reduced the incidence rate of type II diabetes in India.", "Satellite cell dysfunction is a key factor in sarcopenia development.", "The predominant localization of Linc00173 is in mononuclear macrophage nuclei.", "HSCT-T dosage may not be diagnostic if the onset of symptoms occurs less than 3 hours before AMI.", "The World Health Organization's (WHO) data collection process is biased downward by unequal selection of larger outbreaks.", "Upon developing tyrosine-kinase inhibitor resistance, new mutations in epidermal growth factor receptors emerge and cause treatment failure.", "61% of colorectal cancer patients are diagnosed with regional or distant metastases.", "The mean suicide rate in women is higher after miscarriage than live birth."], "hard_negatives": ["Trans-acting factors, such as lncRNAs, influence mRNA translation.", "Cis-acting lncRNAs control the expression of genes that are positioned in the vicinity of their transcription sites.", "Genes involved in pre-mRNA splicing have a significant impact on genome stability.", "Long - range chromatin interactions regulate transcription.", "Pre-mRNAs associated with spliceosomal components are less stable than unassociated splicing substrates.", "Pre-mRNAs associated with spliceosomal components are more stable than unassociated splicing substrates.", "miRNAs regulate a unique suite of mRNAs to maintain homeostasis in cells.", "miRNAs enforce homeostasis by suppressing low-level ''leaky'' transcription.", "Recognition of start codons depends on the translation initiation factor IF3.", "Post-transcriptional handling of mitochondrial transcripts occurs in mitochondrial RNA granules."], "hard_negative": "Trans-acting factors, such as lncRNAs, influence mRNA translation."}
{"query_id": "1312", "query_text": "Transcription factor EB induces transcription of pro-inflammatory cytokines in macrophages infected with Staphylococcus aureus.", "negative": "Persistor cells are one reason for incomplete responses to Tyrosine kinase inhibitor (TKI) therapy in cancer patients.", "negatives": ["Persistor cells are one reason for incomplete responses to Tyrosine kinase inhibitor (TKI) therapy in cancer patients.", "Overexpressing Cnp1 N-tail variants exacerbates the temperature-sensitive growth defect of scm3-139.", "CCL19 is a ligand for CCR7.", "Many cytokines that are produced by cancer cells also contribute to carcinogenesis.", "TMEM27 is a marker for beta cells.", "Sn is present on mature DCs during inflammation in vivo.", "Origin gross domestic product(GDP) is positively related to dengue virus (DENV-1) diffusion in air traffic shipments.", "The amount of publicly available DNA data doubles every 10 months.", "Healthy volunteers exhibit rapid and transient increase of cellular ATP after being bolus-injected with fructose.", "RUNX is not expressed in skin tissue."], "hard_negatives": ["Transcription factor EB induces transcription of pro-inflammatory cytokines in macrophages infected with Staphylococcus aureus.", "KRT17 modulates the expression of the transcriptional regulator AIRE in diseased epithelia.", "Upon viral challenge, influenza-specific memory CD4+ T cells greatly enhance the early production of inflammatory chemokines in the lung.", "Upon viral challenge, influenza-specific memory CD4+ T cells greatly diminish the early production of inflammatory chemokines in the lung.", "Eilat virus (EILV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in nonhuman primates.", "The latent infection of myeloid cells with human cytomegalovirus induces a number of changes in gene expression.", "Ethanol stress increases the expression of IBP in bacteria.", "MUC1-C activates the NF-\u03baB p65 signaling pathway by interacting with I\u03baB kinase \u00df.", "Mice that lack Interferon-\u03b3 or its receptor are highly susceptible to experimental autoimmune myocarditis.", "The DdrB protein from Deinococcus radiodurans functions as a pentamer."], "hard_negative": "Transcription factor EB induces transcription of pro-inflammatory cytokines in macrophages infected with Staphylococcus aureus."}
{"query_id": "1314", "query_text": "Transcription rates in S. cerevisiae range between 0.7 and 2 kb/min.", "negative": "Patients with common epithelial cancers  are more likely to have an emergency event as their first hospital admission if they live in resource-deprived areas.", "negatives": ["Patients with common epithelial cancers  are more likely to have an emergency event as their first hospital admission if they live in resource-deprived areas.", "Obesity decreases life quality.", "Mutations in RIM1 raise levels of IME1 RNA.", "Ethanol stress increases the expression of SRL in bacteria.", "Surfactin producing cells and exopolymer producing cells cooperate to generate \"Van Gogh\" bundles that have sliding abilities on specialized media.", "Normal expression of RUNX1 causes tumorsupressing effects.", "Specialized functional cell types can be derived from human pluripotent stem cells.", "IgA plasma cells that are specific for transglutaminase 2 are scarce in the duodenal mucosa of celiac disease patients when the disease is active.", "A diminished ovarian reserve does not solely indicate infertility in an a priori non-infertile population.", "Human embryonic stem cells have the capacity to give rise to differentiated progeny representative of all three embryonic germ layers."], "hard_negatives": ["Transcription rates in S. cerevisiae range between 0.7 and 2 kb/min.", "Transcription rates in S. cerevisiae range between 7 and 12 kb/min.", "Recognition of start codons depends on the translation initiation factor IF3.", "Glucose restriction to 0.05% reduces RLS (replicative life span) by 20-40% in S. cerevisiae.", "Genes involved in pre-mRNA splicing have a significant impact on genome stability.", "Cellular differentiation of embryonic stem cells is accompanied by changes in replication timing, transcription and nuclear localization.", "Post-transcriptional handling of mitochondrial transcripts occurs in mitochondrial RNA granules.", "miRNAs enforce homeostasis by suppressing low-level ''leaky'' transcription.", "Pre-mRNAs associated with spliceosomal components are more stable than unassociated splicing substrates.", "Pre-mRNAs associated with spliceosomal components are less stable than unassociated splicing substrates."], "hard_negative": "Transcription rates in S. cerevisiae range between 0.7 and 2 kb/min."}
{"query_id": "1315", "query_text": "Transcription rates in S. cerevisiae range between 7 and 12 kb/min.", "negative": "Intramembrane cleavage by signal peptide peptidase aids in the degradation of proteins with a complex membrane orientation.", "negatives": ["Intramembrane cleavage by signal peptide peptidase aids in the degradation of proteins with a complex membrane orientation.", "Human embryonic stem cells have the capacity to give rise to differentiated progeny representative of all three embryonic germ layers.", "Bariatric surgery reduces colorectal cancer.", "Chlamydia trachomatis is most prevalent in the UK among individuals in their 50s and 60s.", "Interleukin-18 plays an important role in the pathogenesis of atherosclerosis.", "Decreased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm.", "Physical activity level is associated with the difference in maximal oxygen consumption between black and white youth.", "Cancer-associated fibroblasts (CAFs) are constituents of tumor microenvironments", "Bariatric surgery reduces postmenopausal breast cancer.", "CD28 signals regulate trafficking of murine auto-reactive T cells into target tissues."], "hard_negatives": ["Transcription rates in S. cerevisiae range between 0.7 and 2 kb/min.", "Transcription rates in S. cerevisiae range between 7 and 12 kb/min.", "Recognition of start codons depends on the translation initiation factor IF3.", "Glucose restriction to 0.05% reduces RLS (replicative life span) by 20-40% in S. cerevisiae.", "Genes involved in pre-mRNA splicing have a significant impact on genome stability.", "Cellular differentiation of embryonic stem cells is accompanied by changes in replication timing, transcription and nuclear localization.", "miRNAs enforce homeostasis by suppressing low-level ''leaky'' transcription.", "Post-transcriptional handling of mitochondrial transcripts occurs in mitochondrial RNA granules.", "Pre-mRNAs associated with spliceosomal components are more stable than unassociated splicing substrates.", "Pre-mRNAs associated with spliceosomal components are less stable than unassociated splicing substrates."], "hard_negative": "Transcription rates in S. cerevisiae range between 0.7 and 2 kb/min."}
{"query_id": "1322", "query_text": "Transplanted human glial progenitor cells can mature in their host animal.", "negative": "In chronic viral infections or tumors, peptides that selectively inhibit PTPRS can be utilized to boost insufficient activity of pDCs.", "negatives": ["In chronic viral infections or tumors, peptides that selectively inhibit PTPRS can be utilized to boost insufficient activity of pDCs.", "Bacteriophagaes MS2 and Q\u03b2 are members of the Leviviridae.", "Bacteriophagaes MS2 and Q\u03b2 are members of the Leviviridae.", "Ten percent (10%) of kidney cancers in the UK are attributable to excess weight.", "Stiff substrates inhibit mesodermal differentiation by degrading beta-catenin in an integrin-dependent manner.", "A high microerythrocyte count protects against severe anemia in homozygous alpha (+)- thalassemia trait subjects.", "There is no known interaction between Pioneer factor OCT3/4 and major chromatin remodeling factors.", "Persistor cells are one reason for incomplete responses to Tyrosine kinase inhibitor (TKI) therapy in cancer patients.", "BiP is a general endoplasmic reticulum stress marker.", "KRT17 modulates the expression of the transcriptional regulator AIRE in diseased epithelia."], "hard_negatives": ["Transplanted human glial progenitor cells can mature in their host animal.", "Human embryonic stem cells have the capacity to give rise to differentiated progeny representative of all three embryonic germ layers.", "Specialized functional cell types can be derived from human pluripotent stem cells.", "Androgenetic haploid mouse embryonic stem cells (ESCs) can be derived and genetically manipulated in vitro.", "Human embryonic stem cells give rise to cell types from the outer embryonic germ layer, but not the other two layers.", "Human embryonic stem cells give rise to cell types from all three embryonic germ layers.", "Autologous transplantation of mesenchymal stem cells has better graft function than induction therapy with anti-interleukin-2 receptor antibodies.", "Mouse models can be generated using \"artificial spermatids.\"", "Nuclear transfer from adult human fibroblasts to human oocytes can give rise to blastocysts containing expandable pluripotent cells.", "Bone marrow cells don't contribute to adult macrophage compartments."], "hard_negative": "Transplanted human glial progenitor cells can mature in their host animal."}
{"query_id": "1323", "query_text": "Treatment with a protein named FN impairs regenerative abilities of aged muscles.", "negative": "Bone Marrow (BM) transplantation is used to treat acute myeloid leukemia (AML)", "negatives": ["Bone Marrow (BM) transplantation is used to treat acute myeloid leukemia (AML)", "Post-transcriptional handling of mitochondrial transcripts occurs in mitochondrial RNA granules.", "Reducing H3k4me3 methylation induces mouse epiblast stem cells to naive pluripotency efficiently.", "Metastatic colorectal cancer treated with a single agent fluoropyrimidines resulted in similar efficacy and better quality of life when compared with oxaliplatin-based chemotherapy in elderly patients.", "Deletion of ATM and Rad3 related protein is not predictive of acute tissue loss.", "YAP/TAZ is required in intestinal regeneration in mouse models of ulcerative colitis.", "53% of perinatal mortality is due to low birth weight.", "Pyridostatin reduces proliferation of homologous recombination - defective cells.", "Immune complex triggered cell death leads to sequestration of oxidized mitochondrial DNA.", "Measuring routine outcomes is more beneficial to clinical practice than assessing treatment adherence."], "hard_negatives": ["Treatment with a protein named FN impairs regenerative abilities of aged muscles.", "Treatment with a protein named FN restores regenerative abilities of aged muscles.", "Physical activity does not improve cognitive function in individuals with Alzheimers.", "Inhibiting focal adhesion formation increases the rate at which cells convert mechanical strain into inflammation and fibrosis.", "Inhibiting focal adhesion formation enables cells to convert mechanical strain into eventual scarring.", "Lack of FGF21 in mice leads to reduced lifespan.", "Rotator cuff exercises are more effective than general exercise therapy in reducing pain and improving function of the shoulder.", "General exercise therapy is more effective than rotator cuff exercises in reducing pain and improving function of the shoulder.", "Surgical treatment is not superior to non-surgical in treating adults with displaced fractures of the proximal humerus.", "Lack of FGF21 in mice increases life expectancy."], "hard_negative": "Treatment with a protein named FN impairs regenerative abilities of aged muscles."}
{"query_id": "1324", "query_text": "Treatment with a protein named FN restores regenerative abilities of aged muscles.", "negative": "The amount of publicly available DNA data doubles every 10 months.", "negatives": ["The amount of publicly available DNA data doubles every 10 months.", "In S. cerevisiae, the absence of RNA surveillance pathways reduces sensitivity to high iron conditions.", "Varying expression levels of EBI2 affect the positioning and migration of B cells.", "Egr2 regulates the homeostasis of B and T cells.", "Specialized functional cell types can be derived from human pluripotent stem cells.", "Vaccinating the gastrointestinal tract induces protection of rectal and vaginal mucosa.", "Gpr124 suppresses BBB breakdown in mouse models of ischemic stroke.", "Interleukin-18 plays an important role in the pathogenesis of atherosclerosis.", "HIV trans-activator protein (TAT) effectively transports large and small molecules across cellular membranes into larger populations of neurons.", "The most prevalent adverse events to Semaglutide are cardiovascular."], "hard_negatives": ["Treatment with a protein named FN restores regenerative abilities of aged muscles.", "Treatment with a protein named FN impairs regenerative abilities of aged muscles.", "Rotator cuff exercises are more effective than general exercise therapy in reducing pain and improving function of the shoulder.", "Physical activity does not improve cognitive function in individuals with Alzheimers.", "General exercise therapy is more effective than rotator cuff exercises in reducing pain and improving function of the shoulder.", "General exercise therapy is more effective than scapular stabilizer exercises in reducing pain and improving function of the shoulder.", "Inhibiting focal adhesion formation increases the rate at which cells convert mechanical strain into inflammation and fibrosis.", "Lack of FGF21 in mice leads to reduced lifespan.", "Scapular stabilizer exercises are more effective than general exercise therapy in reducing pain and improving function of the shoulder.", "Inhibiting focal adhesion formation enables cells to convert mechanical strain into eventual scarring."], "hard_negative": "Treatment with a protein named FN restores regenerative abilities of aged muscles."}
{"query_id": "1325", "query_text": "Treatment with the EC uptake inhibitor AM404 resulted in a dose-dependent decrease in the expression of immobility.", "negative": "Lack of FGF21 in mice leads to reduced lifespan.", "negatives": ["Lack of FGF21 in mice leads to reduced lifespan.", "DMS3 protein enables Pol V transcription in vivo.", "Medications to treat obesity do not have side effects.", "Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission.", "The deregulated and prolonged activation of monocytes has deleterious effects in chronic infectious conditions.", "Intra-cerebroventricular infusion of amyloid-\u03b2 oligomers increases expression of fibronectin type-III domain-containing protein 5 mRNA in mice hippocampi.", "KRT17 modulates the expression of the transcriptional regulator AIRE in diseased epithelia.", "Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes fibrosis.", "Chronic HIV stimulation of B cells leads to the premature exhaustion of B cells.", "Stroke patients with prior use of direct oral anticoagulants have a higher risk of in-hospital mortality than stroke patients with prior use of warfarin."], "hard_negatives": ["Treatment with the EC uptake inhibitor AM404 resulted in a dose-dependent decrease in the expression of immobility.", "Taking anti-depresents is associated with a decrease in the A\u03b2 level in the brain of experimental animals.", "The most prevalent adverse events to Semaglutide are cardiovascular.", "The most prevalent adverse events to Semaglutide are gastrointestinal.", "ITAM phosphorylation allows for the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).", "Activation of PPM1D enhances p53 function.", "Alirocumab treatment reduces apo(a) fractional clearance rate.", "C2 works synergistically with A-769662 to activate dephosphorylated AMPK.", "HSCT-T dosage may not be diagnostic if the onset of symptoms occurs less than 3 hours before AMI.", "p16INK4A degradation is  linked to an abnormal wound response caused by the microinvasive step of advanced Oral Potentially Malignant Lesions (OPMLs)."], "hard_negative": "Treatment with the EC uptake inhibitor AM404 resulted in a dose-dependent decrease in the expression of immobility."}
{"query_id": "1327", "query_text": "Tuberculosis incidence occurs at higher rates in more sparsely populated areas in the UK.", "negative": "Destination container port throughput(CPT) is positively related to dengue virus (DENV-1) diffusion in air traffic shipments.", "negatives": ["Destination container port throughput(CPT) is positively related to dengue virus (DENV-1) diffusion in air traffic shipments.", "Gastric infection with Helicobacter pylori decreases risk of gastric cancer in humans.", "Pharmacist attendance at ward rounds increases adverse events in wards.", "Aged patients are less susceptible to ischaemia/reperfusion injury.", "Incidence of 10/66 dementia is higher than the incidence of DSM-IV dementia.", "Reduction of purity of cytoplasmic membranes isolated from overexpressors is indicated by stronger spots for OmpF in 2D BN-PAGE gels.", "The RANK-RANK-Ligand (RANKL) pathway is involved in the development of Aire-expressing medullary thymic epithelial cells (mTECs).", "ATM and Rad3 related protein have no role in sensing DNA damage.", "HNF4A mutations are associated with macrosomia in infancy.", "Ethanol stress increases the expression of PSP in bacteria."], "hard_negatives": ["Tuberculosis incidence occurs at higher rates in more sparsely populated areas in the UK.", "Antiretroviral therapy increases rates of tuberculosis across a broad range of CD4 strata.", "There was an estimated 30 million cases of pneumonia in young children worldwide in 2010.", "Urbanization is an important risk factor related to the transmission of dengue fever.", "Chlamydia trachomatis is most prevalent in the UK among individuals in their 50s and 60s.", "Sepsis related mortality has risen from 2009 to 2014.", "Incidence of sepsis has fallen substantially from 2009 to 2014.", "Approximately 250,000 people are infected with human T-cell lymphotropic virus type 1 in the United Kingdom.", "In the UK, drowning affects boys and girls equally.", "Malaria has a high vectorial capacity."], "hard_negative": "Tuberculosis incidence occurs at higher rates in more sparsely populated areas in the UK."}
{"query_id": "1328", "query_text": "Tuberculosis-induced granulomas express different immune system protein signatures than the surrounding tissue.", "negative": "Rapid phosphotransfer rates are correlated with histidine kinase regulator specificity.", "negatives": ["Rapid phosphotransfer rates are correlated with histidine kinase regulator specificity.", "Antidepressants reduce the severity of migraines.", "The predominant localization of Linc00173 is in mononuclear macrophage nuclei.", "Increased purity of cytoplasmic membranes isolated from overexpressors is indicated by stronger spots for OmpF in 2D BN-PAGE gels.", "Risk of cardiovascular events can be cut by a third by using antihypertensive drug therapy among hemodialysis patients.", "Chinese individuals with TT homozygosity in the MTHFR gene are more vulnerable to strokes caused by low levels of folate intake.", "The PPR MDA5 has twenty N-terminal CARD domains.", "Klf4 is not required for proper myeloid cell differentiation.", "Nuclear transfer from adult human fibroblasts to human oocytes can give rise to blastocysts containing expandable pluripotent cells.", "miRNAs enforce homeostasis by suppressing low-level ''leaky'' transcription."], "hard_negatives": ["Tuberculosis-induced granulomas express different immune system protein signatures than the surrounding tissue.", "The tissue surrounding the granuloma in an immune cell induces an anti-inflammatory immune response.", "Antiretroviral therapy increases rates of tuberculosis across a broad range of CD4 strata.", "Normal granulomas form in the presence of TNF in Zebrafish.", "Normal granulomas form in the absence of TNF in Zebrafish.", "Cancer-associated fibroblasts (CAFs) have no known interaction with cancer cells in the formation and activation of CAFs.", "Glioblastoma multiforme (GBM) is characterized by extensive invasion, rapid growth, necrosis, and angiogenesis.", "Mice are incapable of producing neutralizing antibodies in reponse to the Chikungunya virus (CHIKV) produced in mosquitos.", "Cancer-associated fibroblasts (CAFs) interact with cancer cells to mediate formation and activation of CAFs.", "The latent infection of myeloid cells with human cytomegalovirus induces a number of changes in gene expression."], "hard_negative": "Tuberculosis-induced granulomas express different immune system protein signatures than the surrounding tissue."}
{"query_id": "1330", "query_text": "Tumor development occurs in conjunction with suppression of pro-inflammatory cytokines.", "negative": "taa1 tar1 tar2 triple mutants in Arabidopsis do not make root meristem during embryogenesis.", "negatives": ["taa1 tar1 tar2 triple mutants in Arabidopsis do not make root meristem during embryogenesis.", "M. stadtmanae induces ASC speck formation in BlaER1 monocytes.", "Helicobacter pylori-induced aberrant NF-kB-dependent expression of activation-induced cytidine deaminase contributes to the mutagenesis of host DNA.", "Mice that lack Interferon-\u03b3 or its receptor are highly susceptible to experimental autoimmune myocarditis.", "Tonic signaling from the scFv induces constitutive stimulation.", "Systemic immunosuppressive (IS) therapy increases the chance of cancer mortality in patients with inflammatory eye disease (IED)", "A 100g dose of chloroquine chemoprophylactic regimen results in retinal toxicity after 5-6 years of weekly intake.", "Diabetes remission occurs less in people treated with conventional therapy than in people treated with laparoscopic adjustable gastric banding surgery.", "AMP-activated protein kinase (AMPK) activation reduces inflammation-related fibrosis in the lungs.", "Increase of p62 in prostate tumor stroma results in defective autophagy."], "hard_negatives": ["Tumor development occurs in conjunction with upregulation of pro-inflammatory cytokines.", "Tumor development occurs in conjunction with suppression of pro-inflammatory cytokines.", "Pro-inflammatory cytokines are up regulated during tumor development.", "Pro-inflammatory cytokines are up repressed during tumor development.", "Primary pro-inflammatory cytokines suppress secondary pro- and anti-inflammatory mediators.", "Many cytokines that are produced by cancer cells also contribute to carcinogenesis.", "Cancer-associated fibroblasts (CAFs) interact with cancer cells to mediate formation and activation of CAFs.", "Notch signaling occurs between tumor cells and stromal cells.", "Cancer-associated fibroblasts (CAFs) have no known interaction with cancer cells in the formation and activation of CAFs.", "Cancer cells can stimulate the accumulation of intra-tumoural myeloid-derived suppressor cells by promoting granulocyte colony stimulating factor production."], "hard_negative": "Tumor development occurs in conjunction with upregulation of pro-inflammatory cytokines."}
{"query_id": "1331", "query_text": "Tumor development occurs in conjunction with upregulation of pro-inflammatory cytokines.", "negative": "Trans-acting factors, such as lncRNAs, influence mRNA translation.", "negatives": ["Trans-acting factors, such as lncRNAs, influence mRNA translation.", "MUC1-C activates the NF-\u03baB p65 signaling pathway by interacting with I\u03baB kinase \u00df.", "Commelina yellow mottle virus (ComYMV) has three typical badnavirus ORFs, capable of encoding proteins 23, 15, and 216 kD.", "Increased conversion of PGE 2 to PPARy ligand 15-ket-PGE 2 causes accumulation of PGE.", "Lamins are associated with nuclear membrane structure maintenance.", "Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection increases dissemination of Salmonella Typhimurium from the gut.", "F4/80+ macrophages regulate mature osteoblast maintenance.", "The minor G allele of FOXO3 downregulates pro-inflammatory cytokines.", "Major antigen-induced signals from the T cell receptor and secondary signals from costimulatory receptors are required for T cell activation.", "The most prevalent adverse events to Semaglutide are gastrointestinal."], "hard_negatives": ["Tumor development occurs in conjunction with upregulation of pro-inflammatory cytokines.", "Tumor development occurs in conjunction with suppression of pro-inflammatory cytokines.", "Pro-inflammatory cytokines are up regulated during tumor development.", "Pro-inflammatory cytokines are up repressed during tumor development.", "Many cytokines that are produced by cancer cells also contribute to carcinogenesis.", "Cancer-associated fibroblasts (CAFs) interact with cancer cells to mediate formation and activation of CAFs.", "Primary pro-inflammatory cytokines suppress secondary pro- and anti-inflammatory mediators.", "Cancer-associated fibroblasts (CAFs) have no known interaction with cancer cells in the formation and activation of CAFs.", "Notch signaling occurs between tumor cells and stromal cells.", "The cytokine receptor which regulates chemotaxis and formation of lymph nodes is involved in production of myeloperoxidase in the left atrium."], "hard_negative": "Tumor development occurs in conjunction with upregulation of pro-inflammatory cytokines."}
{"query_id": "1333", "query_text": "Two variants of chromosome 6q21 are associated with radiation therapy-induced second malignancies in pediatric Hodgkin lymphoma patients.", "negative": "Pharmacist attendance at ward rounds reduces adverse events in wards.", "negatives": ["Pharmacist attendance at ward rounds reduces adverse events in wards.", "The ability of activator E2Fs in preventing cell death is limited to terminally differentiated cells.", "The G34R/V mutation does not create a hypomethylated phenotype at the H3K36 histone.", "Ultrasound guidance significantly reduces the number of traumatic procedures when attempting needle insertion.", "Lysine histone demethylase inhibitor JIB 04 is inactive against KDM5A.", "Helicobacter pylori-induced aberrant NF-kB-dependent expression of activation-induced cytidine deaminase contributes to the mutagenesis of host DNA.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have decreased risk for dementia.", "mcm 5 s 2 U is required for proper decoding of NNR codons in eukaryotes.", "Higher plasma levels of I-carnitine, when associated with trimethylamine N-oxide, are positively correlated with cardiovascular events in humans.", "Forkhead 0 (fox0) transcription factors are involved in apoptosis."], "hard_negatives": ["Two variants of chromosome 6q21 are associated with radiation therapy-induced second malignancies in pediatric Hodgkin lymphoma patients.", "IL-6 signaling plays a major role in atherosclerotic cardiovascular disease.", "miR-142-5P is a temperature-sensitive microRNA (miRNA).", "Interleukin-18 plays an important role in the pathogenesis of atherosclerosis.", "61% of colorectal cancer patients are diagnosed with regional or distant metastases.", "Repressing IL-18 has negative effects on atherosclerotic lesion composition and progression.", "1-1% of colorectal cancer patients are diagnosed with regional or distant metastases.", "Lack of FGF21 in mice leads to reduced lifespan.", "Lack of FGF21 in mice increases life expectancy.", "RAD52 is involved in break-induced DNA replication (BIR)."], "hard_negative": "Two variants of chromosome 6q21 are associated with radiation therapy-induced second malignancies in pediatric Hodgkin lymphoma patients."}
{"query_id": "1334", "query_text": "Type 1 Diabetes is associated with subtle perturbations in T reg development.", "negative": "Autophagy deficiency in the liver increases vulnerability to insulin resistance.", "negatives": ["Autophagy deficiency in the liver increases vulnerability to insulin resistance.", "YAP/TAZ is required in intestinal regeneration in mouse models of ulcerative colitis.", "Forkhead 0 (fox0) transcription factors are involved in cellular differentiation.", "Long chain polyunsaturated fatty acids supplementation has no significant effects on wheezing or asthma at 3 and 6 years.", "Cost effectiveness evaluations based on cRCT data accurately reflect prices for patients in actual clinical practice.", "Risedronate increases risk of vertebral and non-vertebral fractures.", "MeCP2 influences the synaptic maturation of neurons.", "Integrating classroom-based collaborative learning with Web-based collaborative learning offers the best class performance.", "Mice defective for deoxyribonucleic acid (DNA) polymerase I (polI) fail to reveal increased sensitivity to ionizing radiation (IR).", "Amitriptyline is an effective treatment for chronic tension-type headaches."], "hard_negatives": ["Type 1 Diabetes is associated with subtle perturbations in T reg development.", "Reduced responsiveness to interleukin-2 in regulatory T cells is associated with autoimmune diseases such as Type 1 Diabetes.", "CD28 initiates tonic signaling in conventional T cells, which causes an exhaustion phenotype and limited efficiency.", "Major antigen-induced signals from the T cell receptor and secondary signals from costimulatory receptors are required for T cell activation.", "IL-10 production by monocytes inhibits CD4 + T cell response.", "Peroxynitrite is required for induction of T cell tolerance.", "Foxk2 regulates autophagy genes in muscle cells and fibroblast cells.", "Egr2 regulates the homeostasis of B and T cells.", "Foxp3 represses the expression of transcriptional regulators implicated in memory T cell development.", "In pediatric tissue, most T cells are naive T cell emigrants from the thymus."], "hard_negative": "Type 1 Diabetes is associated with subtle perturbations in T reg development."}
{"query_id": "1340", "query_text": "Ultrasound guidance significantly reduces the number of needle insertion attempts necessary for a given procedure.", "negative": "Cnn1 recruitment varies with cell cycle timing.", "negatives": ["Cnn1 recruitment varies with cell cycle timing.", "Bacteriophagaes MS2 and Q\u03b2 are members of the Leviviridae.", "British female students are bullied more than British male students.", "Pioneer factor OCT3/4 interacts with major chromatin remodeling factors.", "Ribosome-inactivating protein-2 (RIP-2) interacts with the p75 NTR death domain", "Many transmembrane receptors transmit signals by long-range conformational changes in the association of alpha-helices across the plasma membrane.", "MafA phosphorylation enhances its ubiquitination.", "Chinese individuals with TT homozygosity in the MTHFR gene are more vulnerable to strokes caused by low levels of folate intake.", "Deltex has no known interactions with eIF3f.", "Medications to treat obesity have unwanted side effects."], "hard_negatives": ["Ultrasound guidance significantly reduces the number of needle insertion attempts necessary for a given procedure.", "Ultrasound guidance significantly reduces the number of traumatic procedures when attempting needle insertion.", "Asymptomatic visual impairment screening in elderly populations leads to improved vision.", "Primary cervical cytology screening with HPV detection has higher longitudinal sensitivity to detect severe cervical intraepithelial neoplasia than conventional cytology.", "Measuring routine outcomes is more beneficial to clinical practice than assessing treatment adherence.", "Flexible molecules experience less steric hindrance in the tumor microenviroment than rigid molecules.", "Assessing treatment adherence is more beneficial to clinical practice than measuring routine outcomes.", "The mean suicide rate in women is lower after miscarriage than live birth.", "Including pharmacists in rounding teams reduces the incidence of adverse drug events (ADEs).", "The mean suicide rate in women is higher after miscarriage than live birth."], "hard_negative": "Ultrasound guidance significantly reduces the number of needle insertion attempts necessary for a given procedure."}
{"query_id": "1341", "query_text": "Ultrasound guidance significantly reduces the number of traumatic procedures when attempting needle insertion.", "negative": "Urbanization is an important risk factor related to the transmission of dengue fever.", "negatives": ["Urbanization is an important risk factor related to the transmission of dengue fever.", "During non-homologous end joining, the ligation step is not as tolerant of disrepairs and other distortions when joining 3' of strand breaks as compared to 5' strand breaks.", "DRD1 proteins enable Pol V transcription in vivo.", "Many transmembrane receptors transmit signals by long-range conformational changes in the association of alpha-helices across the plasma membrane.", "Commelina yellow mottle virus (ComYMV) has three typical badnavirus ORFs, capable of encoding proteins 23, 15, and 216 kD.", "Therapeutics receiving accelerated approval encounter a lower frequency of post-marketing safety events", "Guanine nucleotide exchange factors (GEFs) mediate RhoA activation in response to tensional forces on fibronectin-binding integrins.", "A country's Vaccine Alliance (GAVI) eligibility is not indictivate of accelerated adoption of the Hub vaccine.", "1 in 5 million in UK have abnormal PrP positivity.", "Blocking the interaction between TDP-43 and respiratory complex I proteins ND3 and ND6 prevents TDP-43-induced neuronal loss."], "hard_negatives": ["Ultrasound guidance significantly reduces the number of traumatic procedures when attempting needle insertion.", "Ultrasound guidance significantly reduces the number of needle insertion attempts necessary for a given procedure.", "Surgical treatment is not superior to non-surgical in treating adults with displaced fractures of the proximal humerus.", "Stroke patients with prior use of direct oral anticoagulants have a higher risk of in-hospital mortality than stroke patients with prior use of warfarin.", "Primary cervical cytology screening with HPV detection has higher longitudinal sensitivity to detect severe cervical intraepithelial neoplasia than conventional cytology.", "General exercise therapy is more effective than rotator cuff exercises in reducing pain and improving function of the shoulder.", "Rotator cuff exercises are more effective than general exercise therapy in reducing pain and improving function of the shoulder.", "General exercise therapy is more effective than scapular stabilizer exercises in reducing pain and improving function of the shoulder.", "Propriospinal interneurons that play a role in the plastic reorganization of spinal circuits are integral for recovery from spinal cord injury.", "Scapular stabilizer exercises are more effective than general exercise therapy in reducing pain and improving function of the shoulder."], "hard_negative": "Ultrasound guidance significantly reduces the number of traumatic procedures when attempting needle insertion."}
{"query_id": "1342", "query_text": "Understanding epigenetic regulation of replication is essential for the reational design of episomally replicating vectors.", "negative": "Mutations in RIM1 raise levels of IME1 RNA.", "negatives": ["Mutations in RIM1 raise levels of IME1 RNA.", "Hypothalamic glutamate neurotransmission is unrelated to energy balance.", "Increase of p62 in prostate tumor stroma results in defective autophagy.", "The DEXI promoter region is bound by multiple transcription factors in a murine haematopoietic progenitor cell line.", "The PRDM1 gene is a key determinant of primordial germ cells.", "Pharmacist attendance at ward rounds reduces adverse events in wards.", "The cytokine receptor which regulates chemotaxis and formation of lymph nodes is involved in production of myeloperoxidase in the left atrium.", "There was an estimated 30 million cases of pneumonia in young children worldwide in 2010.", "The artifactual C-terminal helix swapping in the StART domain is observed in the Ups1-Mdm35 heterodimer of the StARkin superfamily.", "At least 85% of patients exposed to radiation have activated markers of myofibroblasts."], "hard_negatives": ["Understanding epigenetic regulation of replication is essential for the reational design of episomally replicating vectors.", "Genes involved in pre-mRNA splicing have a significant impact on genome stability.", "Cellular differentiation of embryonic stem cells is accompanied by changes in replication timing, transcription and nuclear localization.", "Long - range chromatin interactions regulate transcription.", "IFIT1 speeds viral replication by allowing for the proliferation of mis-capped viral RNAs.", "RAD52 is involved in break-induced DNA replication (BIR).", "Binding of p53 to enhancer regions (p53BERs) regulates the activity of p53 transcription and cell cycle arrest through the production of p53-dependent eRNAs.", "Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 encourage West Nile virus replication in cortical neurons.", "A strong bias in the phage genome locations where the spacers were derived has been observed in many CRISPR subtypes that confer the immunity to phage.", "Increased mobility of retrotransposons does not lead to mutation and higher tumorigenesis rates."], "hard_negative": "Understanding epigenetic regulation of replication is essential for the reational design of episomally replicating vectors."}
{"query_id": "1345", "query_text": "Up-regulation of the p53 pathway and related molecular events speeds cancer progression.", "negative": "Including pharmacists in rounding teams reduces the incidence of adverse drug events (ADEs).", "negatives": ["Including pharmacists in rounding teams reduces the incidence of adverse drug events (ADEs).", "Stiff substrates encourage mesodermal differentiation by degrading beta-catenin in an integrin-dependent manner.", "Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes epithelial damage.", "Glycan adaptation involves insertion-deletion events.", "The most prevalent adverse events to Semaglutide are gastrointestinal.", "At least 85% of patients exposed to radiation have activated markers of myofibroblasts.", "The DESMOND program caused substantial weight loss in most participants.", "10% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.", "In melanoma, anti-CTLA-4 treatment reinvigorates exhausted PD-1+Eomes+CD8 T cells.", "Adult tissue-resident macrophages stem from the embryonal yolk sac and fetal liver."], "hard_negatives": ["Up-regulation of the p53 pathway and related molecular events speeds cancer progression.", "Binding of p53 to enhancer regions (p53BERs) regulates the activity of p53 transcription and cell cycle arrest through the production of p53-dependent eRNAs.", "Cancer-associated fibroblasts (CAFs) interact with cancer cells to mediate formation and activation of CAFs.", "Activation of PPM1D enhances p53 function.", "Many cytokines that are produced by cancer cells also contribute to carcinogenesis.", "Cancer-associated fibroblasts (CAFs) have no known interaction with cancer cells in the formation and activation of CAFs.", "Activated Cdk5 regulates DNA damage-induced neuronal death.", "Cellular differentiation of embryonic stem cells is accompanied by changes in replication timing, transcription and nuclear localization.", "Cancers that initially benefit from epidermal growth factor receptor targeted therapies later become refractory through several mechanisms.", "Tumor development occurs in conjunction with upregulation of pro-inflammatory cytokines."], "hard_negative": "Up-regulation of the p53 pathway and related molecular events speeds cancer progression."}
{"query_id": "1346", "query_text": "Upon developing tyrosine-kinase inhibitor resistance, new mutations in epidermal growth factor receptors emerge and cause treatment failure.", "negative": "IL-6 signaling plays a major role in atherosclerotic cardiovascular disease.", "negatives": ["IL-6 signaling plays a major role in atherosclerotic cardiovascular disease.", "Urbanization is an important risk factor related to the transmission of dengue fever.", "Many cytokines that are produced by cancer cells also contribute to carcinogenesis.", "Omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegans.", "Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 encourage West Nile virus replication in cortical neurons.", "IL-10 production by monocytes inhibits CD4 + T cell response.", "Origin gross domestic product(GDP) is negatively related to dengue virus (DENV-1) diffusion in air traffic shipments.", "Transcription factor EB induces transcription of pro-inflammatory cytokines in macrophages infected with Staphylococcus aureus.", "Side effects associated with antidepressants do not represent a mortality risk to postmenopausal women.", "Improvements in OER catalysts show stable activity over several hundred hours."], "hard_negatives": ["Upon developing tyrosine-kinase inhibitor resistance, new mutations in epidermal growth factor receptors emerge and cause treatment failure.", "Cancers that initially benefit from epidermal growth factor receptor targeted therapies later become refractory through several mechanisms.", "MEK inhibitors are effective treatments in RAS-driven mouse models of cancer.", "Fibroblast Growth Factor is a ligand which signals through receptor tyrosine kinases.", "Autophagy deficiency in the liver increases vulnerability to insulin resistance.", "Monoclonal antibody targeting of N-cadherin inhibits growth.", "Environmentally-induced senescence is mimicked in disease modeling by adding specific molecules to the culture system.", "Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes fibrosis.", "Cancer cells can stimulate the accumulation of intra-tumoural myeloid-derived suppressor cells by promoting granulocyte colony stimulating factor production.", "The most prevalent adverse events to Semaglutide are cardiovascular."], "hard_negative": "Upon developing tyrosine-kinase inhibitor resistance, new mutations in epidermal growth factor receptors emerge and cause treatment failure."}
{"query_id": "1347", "query_text": "Upon viral challenge, influenza-specific memory CD4+ T cells greatly diminish the early production of inflammatory chemokines in the lung.", "negative": "Energy balance requires hypothalamic glutamate neurotransmission.", "negatives": ["Energy balance requires hypothalamic glutamate neurotransmission.", "Cancer-associated fibroblasts (CAFs) interact with cancer cells to mediate formation and activation of CAFs.", "In transgenic mice harboring green florescent protein under the control of the Sox2 promoter, more than 50 percent of the cells with green florescent colocalize with cell proliferation markers.", "Tirasemtiv has no effect on cardiac muscle.", "Replacement of OCT4 and SOX2 genes with GATA3 is not capable of reprogramming human cells.", "Obesity raises life quality.", "Mouse models can be generated using \"artificial spermatids.\"", "Tuberculosis incidence occurs at higher rates in more sparsely populated areas in the UK.", "Chlamydia trachomatis is most prevalent in the UK among individuals in their 50s and 60s.", "Omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegans."], "hard_negatives": ["Upon viral challenge, influenza-specific memory CD4+ T cells greatly diminish the early production of inflammatory chemokines in the lung.", "Upon viral challenge, influenza-specific memory CD4+ T cells greatly enhance the early production of inflammatory chemokines in the lung.", "Enhanced early production of inflammatory chemokines damages viral control in the lung.", "CD28 signals regulate trafficking of murine auto-reactive T cells into target tissues.", "The latent infection of myeloid cells with human cytomegalovirus induces a number of changes in gene expression.", "Transcription factor EB induces transcription of pro-inflammatory cytokines in macrophages infected with Staphylococcus aureus.", "CD28 initiates tonic signaling in conventional T cells, which causes an exhaustion phenotype and limited efficiency.", "AMP-activated protein kinase (AMPK) activation reduces inflammation-related fibrosis in the lungs.", "Mice that lack Interferon-\u03b3 or its receptor are highly susceptible to experimental autoimmune myocarditis.", "Eilat virus (EILV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in nonhuman primates."], "hard_negative": "Upon viral challenge, influenza-specific memory CD4+ T cells greatly diminish the early production of inflammatory chemokines in the lung."}
{"query_id": "1348", "query_text": "Upon viral challenge, influenza-specific memory CD4+ T cells greatly enhance the early production of inflammatory chemokines in the lung.", "negative": "TNFAIP3 is a glioblastoma tumor suppressor.", "negatives": ["TNFAIP3 is a glioblastoma tumor suppressor.", "Charcoal shows no benefit for acute paraquat poisoning.", "Immune complex triggered cell death leads to sequestration of oxidized mitochondrial DNA.", "The density of cytokine receptor bearing cells affects the distance over which cytokines act.", "In rhesus macaques, daily subcutaneous injections of tenofovir protects against rectally transmitted simian-human immunodeficiency virus.", "Angiotensin converting enzyme inhibitors are associated with decreased risk for functional renal insufficiency.", "Kir7.1 modulates channel activity by the G protein-coupled melanocortin-4 receptor (MC4R) in the paraventricular nucleus of the hypothalamus.", "Removal of H3K9me3 by ectopic expression of other H3K9 demethylases decreases reprogramming efficiency in SCNT experiments.", "Pyridostatin decreases telomere fragility in BRCA2-deficient cells.", "The number of unfertilized oocytes in mated hermaphrodites increases with age."], "hard_negatives": ["Upon viral challenge, influenza-specific memory CD4+ T cells greatly enhance the early production of inflammatory chemokines in the lung.", "Upon viral challenge, influenza-specific memory CD4+ T cells greatly diminish the early production of inflammatory chemokines in the lung.", "Enhanced early production of inflammatory chemokines damages viral control in the lung.", "CD28 signals regulate trafficking of murine auto-reactive T cells into target tissues.", "Transcription factor EB induces transcription of pro-inflammatory cytokines in macrophages infected with Staphylococcus aureus.", "AMP-activated protein kinase (AMPK) activation reduces inflammation-related fibrosis in the lungs.", "The latent infection of myeloid cells with human cytomegalovirus induces a number of changes in gene expression.", "CD28 initiates tonic signaling in conventional T cells, which causes an exhaustion phenotype and limited efficiency.", "Eilat virus (EILV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in nonhuman primates.", "Tuberculosis-induced granulomas express different immune system protein signatures than the surrounding tissue."], "hard_negative": "Upon viral challenge, influenza-specific memory CD4+ T cells greatly enhance the early production of inflammatory chemokines in the lung."}
{"query_id": "1349", "query_text": "Upregulation of PD1 causes the downmodulation of Satb1.", "negative": "The DESMOND program caused substantial weight loss in most participants.", "negatives": ["The DESMOND program caused substantial weight loss in most participants.", "Individuals with low serum vitamin D concentrations have decreased risk of multiple sclerosis.", "90% of patients with melanoma and an objective response to PD-1 blockade will experience a progression in their melanoma.", "Having a main partner improves HIV outcomes.", "In rhesus macaques, daily subcutaneous injections of tenofovir protects against rectally transmitted simian-human immunodeficiency virus.", "Pioglitazone use is significantly associated with an increased risk of prostate cancer.", "IFI16 impedes STING phosphorylation and translocation, resulting in reduced activation of STING.", "Activated Cdk5 phosphorylates the ATM protein in response to DNA damage.", "Pioglitazone use is significantly associated with an increased risk of pancreatic cancer.", "Antimicrobial agents are more effective due to the pressure of antimicrobial usage."], "hard_negatives": ["Upregulation of PD1 causes the downmodulation of Satb1.", "Upregulation of PD1 causes the upregulation of Satb1.", "PD-1 triggering on monocytes enhances IL-10 production by monocytes.", "Activation of PPM1D enhances p53 function.", "Decrease of p62 in prostate tumor stroma results in defective autophagy.", "Increase of p62 in prostate tumor stroma results in defective autophagy.", "Inhibiting glucose-6-phospate dehydrogenase improves lipogenesis by deactivating LKB1-AMPK signaling.", "90% of patients with melanoma and an objective response to PD-1 blockade will experience a progression in their melanoma.", "Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes fibrosis.", "Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes epithelial damage."], "hard_negative": "Upregulation of PD1 causes the downmodulation of Satb1."}
{"query_id": "1350", "query_text": "Upregulation of PD1 causes the upregulation of Satb1.", "negative": "Birth-weight is negatively associated with breast cancer.", "negatives": ["Birth-weight is negatively associated with breast cancer.", "Genetic deficiency of mast cells leads to decreased weight gain in a mouse model of diet-induced obesity.", "Pre-mRNAs associated with spliceosomal components are more stable than unassociated splicing substrates.", "The PRR MDA5 has a C-terminal domain.", "Localization of PIN1 in the roots of Arabidopsis requires VPS9a", "Removal of H3K9me3 by ectopic expression of other H3K9 demethylases decreases reprogramming efficiency in SCNT experiments.", "NR5A2 is important in reverse cholesterol transport in humans.", "Deleting Raptor increases G-CSF levels.", "In chronic viral infections or tumors, peptides that selectively inhibit PTPRS can be utilized to boost insufficient activity of pDCs.", "Adult tissue-resident macrophages stem from the embryonal yolk sac and fetal liver."], "hard_negatives": ["Upregulation of PD1 causes the upregulation of Satb1.", "Upregulation of PD1 causes the downmodulation of Satb1.", "PD-1 triggering on monocytes enhances IL-10 production by monocytes.", "Activation of PPM1D enhances p53 function.", "Increase of p62 in prostate tumor stroma results in defective autophagy.", "Decrease of p62 in prostate tumor stroma results in defective autophagy.", "90% of patients with melanoma and an objective response to PD-1 blockade will experience a progression in their melanoma.", "Inhibiting glucose-6-phospate dehydrogenase improves lipogenesis by deactivating LKB1-AMPK signaling.", "Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes fibrosis.", "aPKCz causes tumour suppression by affecting glutamine metabolism."], "hard_negative": "Upregulation of PD1 causes the upregulation of Satb1."}
{"query_id": "1351", "query_text": "Upregulation of dynein in Drosophila neurons increases the number of microtubule plus-ends growing toward the cell body of each neuron.", "negative": "ERAP1 SNPs are epistatic to HLA alleles for ankylosing spondylitis.", "negatives": ["ERAP1 SNPs are epistatic to HLA alleles for ankylosing spondylitis.", "Higher plasma levels of I-carnitine, when associated with trimethylamine N-oxide, are negatively correlated with cardiovascular events in humans.", "The morphology change from large white adipocytes to small brown adipocytes is a sign of decreased energy expenditure potential in white adipose tissue.", "In rhesus macaques, daily subcutaneous injections of tenofovir protects against rectally transmitted simian-human immunodeficiency virus.", "Pre-mRNAs associated with spliceosomal components are less stable than unassociated splicing substrates.", "Birth-weight is negatively associated with breast cancer.", "Reduced phosphorylation of PP2A increases HDAC4 dephosphorylation by enhancing PP2A-HDAC4 interaction.", "Reducing H3k4me3 methylation induces mouse epiblast stem cells to naive pluripotency efficiently.", "Comparative transcriptome analysis identified new platelet proteins with structural features suggesting a role in platelet function.", "DMS3 protein enables Pol V transcription in vivo."], "hard_negatives": ["Upregulation of dynein in Drosophila neurons increases the number of microtubule plus-ends growing toward the cell body of each neuron.", "The proliferative capacity of neural progenitors differs across species.", "Hypothalamic glutamate neurotransmission is unrelated to energy balance.", "Mice lacking Sirt1 in Sf1-expressing neurons have increased susceptibility to diet-induced obesity and insulin resistance.", "Guanine nucleotide exchange factors (GEFs) mediate RhoA activation in response to tensional forces on fibronectin-binding integrins.", "Mice lacking Sirt1 in Sf1-expressing neurons are immune to diet-induced obesity and insulin resistance.", "Energy balance requires hypothalamic glutamate neurotransmission.", "HIV trans-activator protein (TAT) effectively transports large and small molecules across cellular membranes into larger populations of neurons.", "The proliferative capacity of progenitors is regulated cell-autonomously.", "MeCP2 influences the synaptic maturation of neurons."], "hard_negative": "Upregulation of dynein in Drosophila neurons increases the number of microtubule plus-ends growing toward the cell body of each neuron."}
{"query_id": "1353", "query_text": "Urbanization is an important risk factor related to the transmission of dengue fever.", "negative": "Increased microtubule acetylation exacerbates LRRK2 Roc-COR domain mutation induced locomotor deficits.", "negatives": ["Increased microtubule acetylation exacerbates LRRK2 Roc-COR domain mutation induced locomotor deficits.", "Perigenital skin is not the primary site of HIV acquisition.", "Bacterial meningitis can be diagnosed on the basis of positive cerebrospinal fluid (CSF) cultures.", "Microcin J25 encourages nucleoside triphosphate (NTP) binding.", "A mutation in HNF4A leads to an increased risk of diabetes by the age of 14 years.", "Mutations in RIM1 decrease levels of IME1 RNA.", "Foxp3 enables the expression of transcriptional regulators implicated in memory T cell development.", "Oxidative phosphorylation is one of the primary glycometabolic pathways in cells.", "Two variants of chromosome 6q21 are associated with radiation therapy-induced second malignancies in pediatric Hodgkin lymphoma patients.", "A 100g dose of chloroquine chemoprophylactic regimen results in retinal toxicity after 1 year of weekly intake."], "hard_negatives": ["Urbanization is an important risk factor related to the transmission of dengue fever.", "Rising temperatures caused by global warming increases risk of dengue fever transmission.", "Rising temperatures caused by global warming lowers the risk of dengue fever transmission.", "Malaria has a high vectorial capacity.", "Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission.", "Tuberculosis incidence occurs at higher rates in more sparsely populated areas in the UK.", "The World Health Organization's (WHO) data collection process is biased downward by unequal selection of larger outbreaks.", "There was an estimated 30 million cases of pneumonia in young children worldwide in 2010.", "Exposure to fine particulate air pollution is unrelated to anxiety prevalence.", "The latent infection of myeloid cells with human cytomegalovirus induces a number of changes in gene expression."], "hard_negative": "Urbanization is an important risk factor related to the transmission of dengue fever."}
{"query_id": "1355", "query_text": "V-9302 inhibits antitumor responses by decreasing cell death and oxidative stress.", "negative": "IFIT1 speeds viral replication by allowing for the proliferation of mis-capped viral RNAs.", "negatives": ["IFIT1 speeds viral replication by allowing for the proliferation of mis-capped viral RNAs.", "BiP is a general endoplasmic reticulum stress marker.", "Walking in traffic areas in London did not improve lung function in elderly adults.", "Rapid phosphotransfer rates are correlated with histidine kinase regulator specificity.", "Rotator cuff exercises are more effective than general exercise therapy in reducing pain and improving function of the shoulder.", "Foxp3 represses the expression of transcriptional regulators implicated in memory T cell development.", "GATA3 regulates self-renewal capacity in bone marrow hematopoietic stem cells.", "Repressing IL-18 has negative effects on atherosclerotic lesion composition and progression.", "Patients with common epithelial cancers  are more likely to have an emergency event as their first hospital admission if they live in resource-deprived areas.", "Risedronate increases risk of vertebral and non-vertebral fractures."], "hard_negatives": ["V-9302 inhibits antitumor responses by decreasing cell death and oxidative stress.", "Sildenafil worsens erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.", "PGE 2 suppresss intestinal tumor growth by altering the expression of tumor suppressing and DNA repair genes.", "aPKCz causes tumour suppression by affecting glutamine metabolism.", "Formation of N-terminal pyroglutamate by glutamine cyclase (GC) competes with NTAQ1 for Nt-Gln substrates.", "MafA ubiquitination increases the recruitment of coavtivator P/CAF by MafA.", "MafA ubiquitination decreases the recruitment of coavtivator P/CAF by MafA.", "Chemical injury represses transglutaminase 2 activity.", "B3-Galectin decreases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR.", "Higher plasma levels of I-carnitine, when associated with trimethylamine N-oxide, are negatively correlated with cardiovascular events in humans."], "hard_negative": "V-9302 inhibits antitumor responses by decreasing cell death and oxidative stress."}
{"query_id": "1356", "query_text": "Vaccinating the gastrointestinal tract induces protection of rectal and vaginal mucosa.", "negative": "Diminished ovarian reserve is a reliable indicator of infertility in a non-infertile population.", "negatives": ["Diminished ovarian reserve is a reliable indicator of infertility in a non-infertile population.", "Recognition of start codons depends on the translation initiation factor IF3.", "Antidepressants reduce the severity of migraines.", "The World Health Organization's (WHO) data collection process is biased downward by unequal selection of larger outbreaks.", "Comparative transcriptome analysis identified new platelet proteins with structural features suggesting a role in platelet function.", "Hematopoietic Stem Cell purification reaches purity rates above 90%.", "Misunderstandings between doctors and patients can lead to non-adherence.", "Individuals with Alzheimers who participate in six months of physical activity improve cognitive function for up to 18 months.", "PrimPol degrades short DNA replication intermediates on the leading strand during DNA replication.", "There is no relation between Erythromycin use and hypertrophic pyloric stenosis."], "hard_negatives": ["Vaccinating the gastrointestinal tract induces protection of rectal and vaginal mucosa.", "Oat tolerant coeliac patients may have oat specific inflammatory cells in their small bowel mucosa.", "Enhanced early production of inflammatory chemokines damages viral control in the lung.", "Noninvasive positive pressure ventilation is not predictive of acute respiratory failure after solid organ transplantation.", "Upon viral challenge, influenza-specific memory CD4+ T cells greatly enhance the early production of inflammatory chemokines in the lung.", "The effect of Lipopolysaccharides on kidney barrier function is dependent on inflammation levels.", "Upon viral challenge, influenza-specific memory CD4+ T cells greatly diminish the early production of inflammatory chemokines in the lung.", "Primary pro-inflammatory cytokines suppress secondary pro- and anti-inflammatory mediators.", "The most prevalent adverse events to Semaglutide are gastrointestinal.", "The cytokine receptor which regulates chemotaxis and formation of lymph nodes is involved in production of myeloperoxidase in the left atrium."], "hard_negative": "Vaccinating the gastrointestinal tract induces protection of rectal and vaginal mucosa."}
{"query_id": "1360", "query_text": "Varenicline monotherapy is more effective after 26 weeks of treatment compared to combination nicotine replacement therapies with varenicline or bupropion.", "negative": "Suboptimal nutrition is a leading cause of premature death", "negatives": ["Suboptimal nutrition is a leading cause of premature death", "Charcoal shows no benefit for acute paraquat poisoning.", "Cellular clocks are associated with mitosis timing in NIH 3T3 cells.", "HAND2 methylation is a key step in early endometrial carcinogenesis.", "Physical activity level is associated with the difference in maximal oxygen consumption between black and white youth.", "Omnivores produce less trimethylamine N-oxide from dietary I-carnitine than vegans.", "Localization of PIN1 in the roots of Arabidopsis requires VPS9a", "Cost effectiveness evaluations based on cRCT data lack external validity.", "Microglia are an innate immune cell type of the peripheral nervous system.", "Obesity raises life quality."], "hard_negatives": ["Varenicline monotherapy is more effective after 26 weeks of treatment compared to combination nicotine replacement therapies with varenicline or bupropion.", "Combination nicotine replacement therapies with varenicline or bupropion are more effective after 12 weeks of reatment compared to varenicline monotherapy.", "Sildenafil worsens erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.", "Side effects associated with antidepressants increases risk of stroke.", "Side effects associated with antidepressants do not represent a mortality risk to postmenopausal women.", "Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission.", "Stroke patients with prior use of direct oral anticoagulants have a higher risk of in-hospital mortality than stroke patients with prior use of warfarin.", "Side effects associated with antidepressants lower risk of myocardial infarction.", "The most prevalent adverse events to Semaglutide are cardiovascular.", "Pioglitazone use is significantly associated with an increased risk of pancreatic cancer."], "hard_negative": "Varenicline monotherapy is more effective after 26 weeks of treatment compared to combination nicotine replacement therapies with varenicline or bupropion."}
{"query_id": "1361", "query_text": "Varying expression levels of EBI2 affect the positioning and migration of B cells.", "negative": "Addition of BMP4, activin A, CHIR99021, and SU504 to reprogramming fibroblasts generates, expands and maintains cardiovascular progenitor cells (CPCs)", "negatives": ["Addition of BMP4, activin A, CHIR99021, and SU504 to reprogramming fibroblasts generates, expands and maintains cardiovascular progenitor cells (CPCs)", "Continued HHV-8 transmission among MSM in San Francisco may be explained by urogenital contact.", "NAC destabilizes NO to increase the effect of contrast agents on renal functions.", "Charcoal is an effective treatment for acute paraquat poisoning.", "Microglia are an innate immune cell type of the peripheral nervous system.", "Human embryonic stem cells have the capacity to give rise to differentiated progeny representative of all three embryonic germ layers.", "The gene daf-16, which encodes forkhead Box O (FOXO), is required for all phenotypes associated with reduced insulin/insulin-like growth factor (Igf) signaling.", "FACT and other histone chaperone(s) compensate for Histone 2A (H2A)-histone 2B (H2B) dimer eviction during the histone exchange process.", "Pyridostatin induces checkpoint activation.", "1-1% of colorectal cancer patients are diagnosed with regional or distant metastases."], "hard_negatives": ["Varying expression levels of EBI2 affect the positioning and migration of B cells.", "B cells go though plasmablast differentiation and antibody production by continuous expression of EBI2.", "Egr2 regulates the homeostasis of B and T cells.", "Egr3 regulates the homeostasis of B and T cells.", "The composition of myosin-II isoform switches from the A isoform to the B isoform during hematopoietic differentiation.", "EGR2 is important to myelination of the peripheral nervous system.", "TMEM27 is a marker for beta cells.", "Neutrophils produce IL-1\u03b2 in response to large particles.", "Exhaustion of B cells contributes to poor Ab response in HIV-infected individuals.", "Mutations in G-Beta protein GNB1 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway."], "hard_negative": "Varying expression levels of EBI2 affect the positioning and migration of B cells."}
{"query_id": "1364", "query_text": "Venules have less significant tunica adventitia than arterioles.", "negative": "Tirasemtiv targets fast-twitch muscle.", "negatives": ["Tirasemtiv targets fast-twitch muscle.", "Taxation of sugar-sweetened beverages reduced the incidence rate of type II diabetes in India.", "\u03b2-sheet opening occurs during pleurotolysin pore formation.", "H4 G94P proteins induce degradation of free histones via Rad53-dependent mechanisms.", "Glucose restriction to 0.05% reduces RLS (replicative life span) by 20-40% in S. cerevisiae.", "Pyridostatin stabilizes the G - quadruplex in the telomeric region.", "Risk-adjusted mortality rates are similar in teaching and non-teaching hospitals.", "Diabetic patients with acute coronary syndrome experience decreased short-term and long-term risk for bleeding events.", "Mice defective for deoxyribonucleic acid (DNA) polymerase m (polm) reveal increased sensitivity to ionizing radiation (IR).", "Bariatric surgery leads to positive outcomes in mental health."], "hard_negatives": ["Venules have less significant tunica adventitia than arterioles.", "Flexible molecules experience less steric hindrance in the tumor microenviroment than rigid molecules.", "\u03b2-sheet opening occurs during pleurotolysin pore formation.", "Increased vessel density along with a reduction in fibrosis improves the efficacy of chemotherapy treatments.", "Stiff substrates encourage mesodermal differentiation by degrading beta-catenin in an integrin-dependent manner.", "Stiff substrates inhibit mesodermal differentiation by degrading beta-catenin in an integrin-dependent manner.", "Lamins are found within the inner layer of the nuclear membrane of all cells.", "Inhibiting focal adhesion formation increases the rate at which cells convert mechanical strain into inflammation and fibrosis.", "Osteoparthritis (OA) is characterized by degeneration of articular cartilage, joint edge, and subchondral bone hyperplasia.", "Myelin sheaths are lipid-rich cellular structures."], "hard_negative": "Venules have less significant tunica adventitia than arterioles."}
{"query_id": "1366", "query_text": "VgrG (Tssl) protein punctures membranes by forming a spike at the tip of the tube apparatus.", "negative": "Sympathetic nerve activity is elevated throughout normal pregnancy.", "negatives": ["Sympathetic nerve activity is elevated throughout normal pregnancy.", "Upon viral challenge, influenza-specific memory CD4+ T cells greatly enhance the early production of inflammatory chemokines in the lung.", "Rapamycin increases the concentration of triacylglycerols in fruit flies.", "Cholesterol loading induces KLF4 expression in VSMCs, resulting in the expression of pro-inflammatory cytokines.", "The DESMOND program demonstrates no significant impact on biochemical outcomes.", "Rapid phosphotransfer rates are correlated with histidine kinase regulator specificity.", "Natriuretic peptides protect against diabetes.", "In British Men, haplogroup I decreases risk of cardiovascular disease.", "High levels of CRP lead to a higher risk of exacerbations in chronic obstructive pulmonary disease (COPD).", "Oxidative DNA damage activates STING signalling."], "hard_negatives": ["VgrG (Tssl) protein punctures membranes by forming a spike at the tip of the tube apparatus.", "Intramembrane cleavage by signal peptide peptidase aids in the degradation of proteins with a complex membrane orientation.", "Many transmembrane receptors transmit signals by long-range conformational changes in the association of alpha-helices across the plasma membrane.", "The tip of the inner tube of the toxic type VI secretion system (T6SS) antibacterial effector in Escherichia coli (E. coli) is decorated with VgrG and PAAR proteins.", "Neutrophil extracellular trap (NET) antigens may contain the targeted autoantigens PR3 and MPO.", "Ly49Q directs the organization of neutrophil polarization by regulating membrane raft functions.", "\u03b2-sheet opening occurs during pleurotolysin pore formation.", "The C-type lectin receptor (CLEC-2) rearranges the actin cytoskeleton in dendritic cells to promote efficient motility along stromal surfaces.", "Piezo1 channels are sensors for cell migration in epithelial cells.", "Drosophila supracellular actomyosin structures are found at boundaries in wing imaginal discs."], "hard_negative": "VgrG (Tssl) protein punctures membranes by forming a spike at the tip of the tube apparatus."}
{"query_id": "1367", "query_text": "Vitamin D deficiency effects birth weight.", "negative": "Nigerian physicians constitue the largest component of sub-Saharan Africa-trained physicians in the United States.", "negatives": ["Nigerian physicians constitue the largest component of sub-Saharan Africa-trained physicians in the United States.", "Pre-mRNAs associated with spliceosomal components are more stable than unassociated splicing substrates.", "Helminths interfere with immune system control of coinfections by microbial pathogens 16.", "Deletion of ATM and Rad3 related protein leads to acute tissue loss.", "eRNAs influence is linked to senescence, aging, and carcinogenesis.", "British female students are bullied more than British male students.", "Continued HHV-8 transmission among MSM in San Francisco may be explained by urogenital contact.", "Lamins are found within the inner layer of the mitochondrial membrane of all cells.", "Reducing H3k4me3 methylation induces mouse epiblast stem cells to naive pluripotency efficiently.", "siRNA knockdown of A20 slows tumor progression in an in vivo murine xenograft model."], "hard_negatives": ["Vitamin D deficiency effects birth weight.", "Vitamin D is an important factor in the relationship between calcium and parathyroid hormone.", "Birth-weight is negatively associated with breast cancer.", "A deficiency of vitamin B12 decreases blood levels of homocysteine.", "Excess gestational weight gain is associated with obesity-related pregnancy outcomes.", "40mg/day dosage of folic acid and 2mg/day dosage of vitamin B12 does not affect chronic kidney disease (CKD) progression.", "53% of perinatal mortality is due to low birth weight.", "A deficiency of folate increases blood levels of homocysteine.", "The mean suicide rate in women is lower after miscarriage than live birth.", "A deficiency of vitamin B6 decreases blood levels of homocysteine."], "hard_negative": "Vitamin D deficiency effects birth weight."}
{"query_id": "1371", "query_text": "Vitamin D is an important factor in the relationship between calcium and parathyroid hormone.", "negative": "Charcoal shows no benefit for acute paraquat poisoning.", "negatives": ["Charcoal shows no benefit for acute paraquat poisoning.", "BCL-2 activation antagonizes the apoptotic effects of c-Myc.", "Overexpressing Cnp1 N-tail variants rescues the temperature-sensitive growth defect of scm3-139.", "Gastric lavage is an effective treatment for acute paraquat poisoning.", "Long chain polyunsaturated fatty acids supplementation has no significant effects on wheezing or asthma at 3 and 6 years.", "Side effects associated with antidepressants lower risk of myocardial infarction.", "Scapular stabilizer exercises are more effective than general exercise therapy in reducing pain and improving function of the shoulder.", "Pioneer factor OCT3/4 interacts with major chromatin remodeling factors.", "Nonhuman primates are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.", "Ethanol stress increases the expression of PSP in bacteria."], "hard_negatives": ["Vitamin D is an important factor in the relationship between calcium and parathyroid hormone.", "Vitamin D deficiency effects birth weight.", "A deficiency of vitamin B12 decreases blood levels of homocysteine.", "Intake of folic acid (FA) and vitamin B6 (VB6) increases levels of homocysteine.", "A deficiency of folate increases blood levels of homocysteine.", "Intake of folic acid (FA) and vitamin B6 (VB6) reduces levels of homocysteine.", "Sildenafil worsens erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.", "A deficiency of vitamin B6 decreases blood levels of homocysteine.", "LDL cholesterol has a causal role in the development of cardiovascular disease.", "40mg/day dosage of folic acid and 2mg/day dosage of vitamin B12 does not affect chronic kidney disease (CKD) progression."], "hard_negative": "Vitamin D is an important factor in the relationship between calcium and parathyroid hormone."}
{"query_id": "1372", "query_text": "Walking in traffic areas in London did not improve lung function in elderly adults.", "negative": "A deficiency of vitamin B6 decreases blood levels of homocysteine.", "negatives": ["A deficiency of vitamin B6 decreases blood levels of homocysteine.", "Pro-inflammatory cytokines are up repressed during tumor development.", "Physical injury represses transgultaminase activity.", "Aged patients are more susceptible to ischaemia/reperfusion injury.", "Tuberculosis incidence occurs at higher rates in more sparsely populated areas in the UK.", "Mutations in RIM1 decrease levels of IME1 RNA.", "Rhythmic expression of Cry1 translates directly into a circadian regulation of cAMP signaling in hepatic glucose metabolism.", "Prescribed exercise training improves quality of life.", "C2 works synergistically with A-769662 to activate dephosphorylated AMPK.", "Varying expression levels of EBI2 affect the positioning and migration of B cells."], "hard_negatives": ["Walking in traffic areas in London did not improve lung function in elderly adults.", "Walking in traffic areas in London improves lung function in elderly adults.", "Participants who quit smoking reduce lung cancer risk by approximately 50%.", "AMP-activated protein kinase (AMPK) activation reduces inflammation-related fibrosis in the lungs.", "Tuberculosis incidence occurs at higher rates in more sparsely populated areas in the UK.", "Nonhypertensive people who are 55 years old have a 90% chance of developing hypertension during their lifetime.", "Exercise reduces cancer mortality rates among Chinese citizens.", "Exercise increases cancer mortality rates among Chinese citizens.", "Physical activity does not improve cognitive function in individuals with Alzheimers.", "High levels of CRP lead to a higher risk of exacerbations in chronic obstructive pulmonary disease (COPD)."], "hard_negative": "Walking in traffic areas in London did not improve lung function in elderly adults."}
{"query_id": "1373", "query_text": "Walking in traffic areas in London improves lung function in elderly adults.", "negative": "NAC destabilizes NO to increase the effect of contrast agents on renal functions.", "negatives": ["NAC destabilizes NO to increase the effect of contrast agents on renal functions.", "Homozygous deletion of murine Sbds gene from osterix-expressing mesenchymal stem and progenitor cells (MPCs) induces oxidative stress.", "The PRDM1 gene, when combined with the PRDM14 gene, plays an important role during primordial germ cell specification.", "r-protein chaperones are found in complexes with their r-protein binding partners.", "Glioblastoma multiforme (GBM) is characterized by extensive invasion, rapid growth, necrosis, and angiogenesis.", "Pyridostatin prevents double-strand breaks accumulation.", "M. stadtmanae induces ASC speck formation in BlaER1 monocytes.", "Taxation of sugar-sweetened beverages reduced the incidence rate of type II diabetes in India.", "The C-type lectin receptor (CLEC-2) rearranges the actin cytoskeleton in dendritic cells to promote efficient motility along stromal surfaces.", "H4 G94P proteins suppress degradation of free histones via Rad53-dependent mechanisms."], "hard_negatives": ["Walking in traffic areas in London improves lung function in elderly adults.", "Walking in traffic areas in London did not improve lung function in elderly adults.", "AMP-activated protein kinase (AMPK) activation reduces inflammation-related fibrosis in the lungs.", "Exercise reduces cancer mortality rates among Chinese citizens.", "Exercise increases cancer mortality rates among Chinese citizens.", "Tuberculosis incidence occurs at higher rates in more sparsely populated areas in the UK.", "Participants who quit smoking reduce lung cancer risk by approximately 50%.", "Nonhypertensive people who are 55 years old have a 90% chance of developing hypertension during their lifetime.", "Physical activity does not improve cognitive function in individuals with Alzheimers.", "Physical activity level is associated with the difference in maximal oxygen consumption between black and white youth."], "hard_negative": "Walking in traffic areas in London improves lung function in elderly adults."}
{"query_id": "1374", "query_text": "Weighed food records (WFR) result in high completion since they're cheap to run and impose low participant burden.", "negative": "Low nucleosome occupancy correlates with high methylation levels across species.", "negatives": ["Low nucleosome occupancy correlates with high methylation levels across species.", "Inhibiting focal adhesion formation increases the rate at which cells convert mechanical strain into inflammation and fibrosis.", "Origin gross domestic product(GDP) is negatively related to dengue virus (DENV-1) diffusion in air traffic shipments.", "Dscam1 acts as a hypervariable pattern-recognition receptor for the immune system.", "90% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.", "Higher plasma levels of I-carnitine, when associated with trimethylamine N-oxide, are positively correlated with cardiovascular events in humans.", "Exercise increases cancer mortality rates among Chinese citizens.", "Certain immunomodulator-human dialyzable leukocyte extract (hDLE) peptides are recognized by toll-like receptors (TLRs) on macrophages and dendritic cells.", "Monoclonal antibody targeting of N-cadherin inhibits castration resistance.", "In domesticated populations of Saccharomyces cerevisiae, segmental aneuploidy is very common."], "hard_negatives": ["Weighed food records (WFR) result in high completion since they're cheap to run and impose low participant burden.", "Weighed food records (WFR) result in poor completion since they're costly to run and impose high participant burden.", "Cost effectiveness evaluations based on cRCT data lack external validity.", "Cost effectiveness evaluations based on cRCT data accurately reflect prices for patients in actual clinical practice.", "Including pharmacists in rounding teams does not alter the incidence of adverse drug events (ADEs).", "Glucose restriction to 0.05% reduces RLS (replicative life span) by 20-40% in S. cerevisiae.", "Including pharmacists in rounding teams reduces the incidence of adverse drug events (ADEs).", "Polymeal nutrition increases cardiovascular mortality.", "Measuring routine outcomes is more beneficial to clinical practice than assessing treatment adherence.", "A country's Vaccine Alliance (GAVI) eligibility is not indictivate of accelerated adoption of the Hub vaccine."], "hard_negative": "Weighed food records (WFR) result in high completion since they're cheap to run and impose low participant burden."}
{"query_id": "1375", "query_text": "Weighed food records (WFR) result in poor completion since they're costly to run and impose high participant burden.", "negative": "Notch signaling occurs between tumor cells and stromal cells.", "negatives": ["Notch signaling occurs between tumor cells and stromal cells.", "The removal of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells.", "10% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.", "In British Men, haplogroup I increases risk of cardiovascular disease by 50%.", "siRNA knockdown of A20 slows tumor progression in an in vivo murine xenograft model.", "Nonsteroidal antinflammatory drugs are ineffective as cancer treatments.", "Transcription factor EB induces transcription of pro-inflammatory cytokines in macrophages infected with Staphylococcus aureus.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have decreased risk for dementia.", "HIV trans-activator protein (TAT) effectively transports large and small molecules across cellular membranes into larger populations of neurons.", "Adult tissue-resident macrophages stem from the embryonal yolk sac and fetal liver."], "hard_negatives": ["Weighed food records (WFR) result in poor completion since they're costly to run and impose high participant burden.", "Weighed food records (WFR) result in high completion since they're cheap to run and impose low participant burden.", "Cost effectiveness evaluations based on cRCT data lack external validity.", "Cost effectiveness evaluations based on cRCT data accurately reflect prices for patients in actual clinical practice.", "Including pharmacists in rounding teams does not alter the incidence of adverse drug events (ADEs).", "Including pharmacists in rounding teams reduces the incidence of adverse drug events (ADEs).", "Measuring routine outcomes is more beneficial to clinical practice than assessing treatment adherence.", "Polymeal nutrition increases cardiovascular mortality.", "Glucose restriction to 0.05% reduces RLS (replicative life span) by 20-40% in S. cerevisiae.", "Moderate consumption of candy and chocolate reduces the risk of cardiovascular disease (CVD)."], "hard_negative": "Weighed food records (WFR) result in poor completion since they're costly to run and impose high participant burden."}
{"query_id": "1376", "query_text": "Whole brain radiotherapy increases the occurrence of new brain metastases.", "negative": "Ca2+ cycling is a UCP1-independent thermogenic mechanism.", "negatives": ["Ca2+ cycling is a UCP1-independent thermogenic mechanism.", "7-day-old adult Caenorhabditis elegans exhibit approximately 75% of the learning capacity seen in 1-day old adults.", "Pyridostatin prevents double-strand breaks accumulation.", "Women with a lower birth weight are more likely to develop breast cancer later in life.", "In transgenic mice harboring green florescent protein under the control of the Sox2 promoter, more than 50 percent of the cells with green florescent colocalize with cell proliferation markers.", "Helicobacter pylori-induced aberrant NF-kB-dependent expression of activation-induced cytidine deaminase contributes to the mutagenesis of host DNA.", "Vaccinating the gastrointestinal tract induces protection of rectal and vaginal mucosa.", "VgrG (Tssl) protein punctures membranes by forming a spike at the tip of the tube apparatus.", "Exposure to fine particulate air pollution is unrelated to anxiety prevalence.", "Foxp3 enables the expression of transcriptional regulators implicated in memory T cell development."], "hard_negatives": ["Whole brain radiotherapy increases the occurrence of new brain metastases.", "Physical activity does not improve cognitive function in individuals with Alzheimers.", "Genomic aberrations of metastases provide information for targeted therapy.", "Antidepressants increase the severity of migraines.", "At least 85% of patients exposed to radiation have activated markers of myofibroblasts.", "Headaches are correlated with cognitive impairment.", "Individuals with Alzheimers who participate in six months of physical activity improve cognitive function for up to 18 months.", "G-CSF increases the expansion and infiltration of MDSCs into tumors.", "Antidepressants reduce the severity of migraines.", "In patients with congenital heart defects, \u03b2-blockers significantly improve clinical heart failure outcomes."], "hard_negative": "Whole brain radiotherapy increases the occurrence of new brain metastases."}
{"query_id": "1378", "query_text": "Women are more susceptible to death due to pneumonia when compared to men.", "negative": "Continued HHV-8 transmission among MSM in San Francisco may be explained by urogenital contact.", "negatives": ["Continued HHV-8 transmission among MSM in San Francisco may be explained by urogenital contact.", "Genetic deficiency of mast cells leads to decreased weight gain in a mouse model of diet-induced obesity.", "Rising temperatures caused by global warming increases risk of dengue fever transmission.", "Tumor development occurs in conjunction with suppression of pro-inflammatory cytokines.", "M. stadtmanae induces ASC speck formation in BlaER1 monocytes.", "Amitriptyline is an effective treatment for chronic tension-type headaches.", "Understanding epigenetic regulation of replication is essential for the reational design of episomally replicating vectors.", "siRNA knockdown of A20 slows tumor progression in an in vivo murine xenograft model.", "Cognitive behavioral therapy is an ineffective treatment for insomnia", "CD28 signals regulate trafficking of murine auto-reactive T cells into target tissues."], "hard_negatives": ["Women are more susceptible to death due to pneumonia when compared to men.", "Men are more susceptible to death due to pneumonia when compared to women.", "There was an estimated 30 million cases of pneumonia in young children worldwide in 2010.", "The mean suicide rate in women is lower after miscarriage than live birth.", "The mean suicide rate in women is higher after miscarriage than live birth.", "Women with a lower birth weight are more likely to develop breast cancer later in life.", "Bacterial meningitis can be diagnosed on the basis of positive cerebrospinal fluid (CSF) cultures.", "Tuberculosis incidence occurs at higher rates in more sparsely populated areas in the UK.", "Rising temperatures caused by global warming increases risk of dengue fever transmission.", "Urbanization is an important risk factor related to the transmission of dengue fever."], "hard_negative": "Women are more susceptible to death due to pneumonia when compared to men."}
{"query_id": "1380", "query_text": "Women with a lower birth weight are more likely to develop breast cancer later in life.", "negative": "Side effects associated with antidepressants increases risk of stroke.", "negatives": ["Side effects associated with antidepressants increases risk of stroke.", "Ten percent (10%) of kidney cancers in the UK are attributable to excess weight.", "ALDH1 expression is associated with poorer prognosis for breast cancer primary tumors.", "PD-1 triggering on monocytes enhances IL-10 production by monocytes.", "Perigenital skin is not the primary site of HIV acquisition.", "There is no association between HNF4A mutations and diabetes risks.", "General exercise therapy is more effective than rotator cuff exercises in reducing pain and improving function of the shoulder.", "Immune responses in immune cells are geographically segregated.", "90% of patients with melanoma and an objective response to PD-1 blockade will experience a progression in their melanoma.", "Therapeutics receiving accelerated approval encounter a lower frequency of post-marketing safety events"], "hard_negatives": ["Women with a lower birth weight are more likely to develop breast cancer later in life.", "The risk of breast cancer among parous women decreases with placental weight of pregnancies.", "Birth-weight is negatively associated with breast cancer.", "The mean suicide rate in women is lower after miscarriage than live birth.", "The mean suicide rate in women is higher after miscarriage than live birth.", "53% of perinatal mortality is due to low birth weight.", "Excess gestational weight gain is associated with obesity-related pregnancy outcomes.", "Ten percent (10%) of kidney cancers in the UK are attributable to excess weight.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have shorter lifetime exposure to estrogen due to a decreased reproductive period.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have longer lifetime exposure to estrogen due to an increased reproductive period."], "hard_negative": "Women with a lower birth weight are more likely to develop breast cancer later in life."}
{"query_id": "1381", "query_text": "YAP/TAZ is required in intestinal regeneration in mouse models of ulcerative colitis.", "negative": "Helminths interfere with immune system control of coinfections by microbial pathogens 16.", "negatives": ["Helminths interfere with immune system control of coinfections by microbial pathogens 16.", "Occipital activation levels are associated with auditory spatial performance in parietal regions of the brain.", "Decrease of p62 in prostate tumor stroma results in defective autophagy.", "Bariatric surgery reduces postmenopausal breast cancer.", "A mutation in HNF4A leads to an increased risk of diabetes by the age of 14 years.", "Hypothalamic glutamate neurotransmission is unrelated to energy balance.", "The first MBT repeat of the four malignant brain tumor (4MBT) domain of Drosophila's Sfmbt and of the orthologous mammalian L3MBTL2 is required for the interaction with the spacer region of Drosophila's Pleiohomeotic (Pho) or its human ortholog YY1.", "The ability of activator E2Fs in preventing cell death is limited to terminally differentiated cells.", "Vitamin D is an important factor in the relationship between calcium and parathyroid hormone.", "MICAL redox enzymes regulate actin dynamics."], "hard_negatives": ["YAP/TAZ is required in intestinal regeneration in mouse models of ulcerative colitis.", "p16INK4A degradation is  linked to an abnormal wound response caused by the microinvasive step of advanced Oral Potentially Malignant Lesions (OPMLs).", "4-PBA treatment decreases endoplasmic reticulum stress in response to general endoplasmic reticulum stress markers.", "Mutant mice lacking SVCT2 have severely reduced ascorbic acid levels in both brain and adrenals.", "Noninvasive positive pressure ventilation is not predictive of acute respiratory failure after solid organ transplantation.", "4-PBA treatment raises endoplasmic reticulum stress in response to general endoplasmic reticulum stress markers.", "Gpr124 increases BBB breakdown in mouse models of ischemic stroke.", "Gpr124 suppresses BBB breakdown in mouse models of ischemic stroke.", "CHOP is a general endoplasmic reticulum stress marker.", "Oat tolerant coeliac patients may have oat specific inflammatory cells in their small bowel mucosa."], "hard_negative": "YAP/TAZ is required in intestinal regeneration in mouse models of ulcerative colitis."}
{"query_id": "1383", "query_text": "aPKCz causes tumour suppression by affecting glutamine metabolism.", "negative": "BRCA 1 mutation carriers' risk of breast and ovarian cancer depends on where the mutation is located.", "negatives": ["BRCA 1 mutation carriers' risk of breast and ovarian cancer depends on where the mutation is located.", "Pyridostatin stabilizes the G - quadruplex in the telomeric region.", "Diabetes remission occurs more in people treated with conventional therapy than in people treated with laparoscopic adjustable gastric banding surgery.", "De novo assembly of sequence data has fewer specific contigs than unassembled sequence data.", "DUSP4 downregulation deactivates the Ras-ERK pathway", "Crossover hot spots are found within gene promoters in Saccharomyces cerevisiae.", "Consumption of whole fruits increases the risk of type 2 diabetes.", "Adult tissue-resident macrophages are seeded before birth.", "Increased conversion of PGE 2 to PPARy ligand 15-ket-PGE 2 causes accumulation of PGE.", "Sudden death can occur in patients with orthostatic hypertension without cardiac conduction abnormalities."], "hard_negatives": ["aPKCz causes tumour suppression by affecting glutamine metabolism.", "The M2-phenotype in brown adipose tissue macrophages increases brown adipose tissue thermogenic activity.", "Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes fibrosis.", "Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes epithelial damage.", "Cancer cells can stimulate the accumulation of intra-tumoural myeloid-derived suppressor cells by promoting granulocyte colony stimulating factor production.", "Reduced levels of lipolysis leads to higher P38 phosphorylation in adipose tissue.", "Increased lipolysis leads to higher P38 phosphorylation in adipose tissue.", "An M2-like phenotype in brown adipose tissue macrophages is quickly induced by cold exposure.", "Inhibiting glucose-6-phospate dehydrogenase improves lipogenesis by deactivating LKB1-AMPK signaling.", "Upregulation of PD1 causes the upregulation of Satb1."], "hard_negative": "aPKCz causes tumour suppression by affecting glutamine metabolism."}
{"query_id": "1386", "query_text": "cSMAC formation represses weak ligand signalling.", "negative": "Pyridostatin decreases telomere fragility in BRCA2-deficient cells.", "negatives": ["Pyridostatin decreases telomere fragility in BRCA2-deficient cells.", "The mean suicide rate in women is higher after miscarriage than live birth.", "The cytokine receptor which regulates chemotaxis and formation of lymph nodes is involved in production of myeloperoxidase in the left atrium.", "MafA ubiquitination decreases the recruitment of coavtivator P/CAF by MafA.", "KRT17 modulates the expression of the transcriptional regulator AIRE in diseased epithelia.", "General exercise therapy is more effective than rotator cuff exercises in reducing pain and improving function of the shoulder.", "Walking in traffic areas in London improves lung function in elderly adults.", "Transplanted human glial progenitor cells can mature in their host animal.", "MeCP2 influences the synaptic maturation of neurons.", "Origin gross domestic product(GDP) is positively related to dengue virus (DENV-1) diffusion in air traffic shipments."], "hard_negatives": ["cSMAC formation represses weak ligand signalling.", "CD28 initiates tonic signaling in conventional T cells, which causes an exhaustion phenotype and limited efficiency.", "Deleting Raptor increases G-CSF levels.", "Tonic signaling from the scFv induces constitutive stimulation.", "Tonic signaling from the scFv prevents constitutive stimulation.", "T cell receptor /CD3 microdomains are required to induce the immunologic synapse.", "Osteocytes have an essential role in G-CSF induced HSPC mobilization.", "CD28 signals regulate trafficking of murine auto-reactive T cells into target tissues.", "G-CSF increases the expansion and infiltration of MDSCs into tumors.", "MafA ubiquitination decreases the recruitment of coavtivator P/CAF by MafA."], "hard_negative": "cSMAC formation represses weak ligand signalling."}
{"query_id": "1387", "query_text": "eRNAs influence is linked to senescence, aging, and carcinogenesis.", "negative": "Stiff substrates inhibit mesodermal differentiation by degrading beta-catenin in an integrin-dependent manner.", "negatives": ["Stiff substrates inhibit mesodermal differentiation by degrading beta-catenin in an integrin-dependent manner.", "Differentiation of progenitor cells to myeloid cells is skewed upon activation of insulin signaling.", "Deltex interacts with eIF3. There is no known interaction between Deltex and elF3", "7-day-old adult Caenorhabditis elegans exhibit approximately 5% of the learning capacity seen in 1-day old adults.", "Increased flux of microbial products provokes immune responses.", "The deregulated and prolonged activation of monocytes improves inflammatory disease outcomes.", "Certain immunomodulator-human dialyzable leukocyte extract (hDLE) peptides are recognized by toll-like receptors (TLRs) on macrophages and dendritic cells.", "Certain immunomodulator-human dialyzable leukocyte extract (hDLE) peptides are recognized by toll-like receptors (TLRs) on macrophages and dendritic cells.", "Albendazole is used to treat soil-transmitted helminths.", "PTEN is a regulator for the transcriptional activity of SRF"], "hard_negatives": ["eRNAs influence is linked to senescence, aging, and carcinogenesis.", "Binding of p53 to enhancer regions (p53BERs) regulates the activity of p53 transcription and cell cycle arrest through the production of p53-dependent eRNAs.", "NR5A2 does not play a role in development of endometrial tissues.", "Rhythmic expression of Cry1 translates directly into a circadian regulation of cAMP signaling in gluconeogenesis.", "Environmentally-induced senescence is mimicked in disease modeling by adding specific molecules to the culture system.", "EGR2 is important to myelination of the peripheral nervous system.", "Many cytokines that are produced by cancer cells also contribute to carcinogenesis.", "Activated Cdk5 regulates DNA damage-induced neuronal death.", "NR5A2 is important in reverse cholesterol transport in humans.", "Active caspase-11 participate in regulating phagosome-lysosome fusion."], "hard_negative": "eRNAs influence is linked to senescence, aging, and carcinogenesis."}
{"query_id": "1390", "query_text": "mcm 5 s 2 U is required for proper decoding of NNR codons in eukaryotes.", "negative": "Deltex interacts with eIF3. There is no known interaction between Deltex and elF3", "negatives": ["Deltex interacts with eIF3. There is no known interaction between Deltex and elF3", "A 100g dose of chloroquine chemoprophylactic regimen results in retinal toxicity after 5-6 years of weekly intake.", "1-1% of colorectal cancer patients are diagnosed with regional or distant metastases.", "Incidence of heart failure increased by 10% in women since 1979.", "There is a positive correlation between hip fractures and statin use.", "Differentiated E2f-1, -2, -3 TKO cells in the intestine do not exhibit apoptosis.", "Crossover hot spots are found within gene promoters in Saccharomyces cerevisiae.", "Side effects associated with antidepressants lower risk of myocardial infarction.", "BiP is a general endoplasmic reticulum stress marker.", "Exhaustion of B cells contributes to poor Ab response in HIV-infected individuals."], "hard_negatives": ["mcm 5 s 2 U is required for proper decoding of NNR codons in eukaryotes.", "Recognition of start codons depends on the translation initiation factor IF3.", "R2D2 stops miRNA production by increasing the selectivity of Dcr2 for long dsRNA.", "Pseudoknots are not evolutionarily conserved in most eukaryotes.", "During non-homologous end joining, the ligation step is not as tolerant of disrepairs and other distortions when joining 5' of strand breaks as compared to 3' strand breaks.", "Bcp1 is a chaperone for Rpl23.", "During non-homologous end joining, the ligation step is not as tolerant of disrepairs and other distortions when joining 3' of strand breaks as compared to 5' strand breaks.", "The PPR MDA5 has twenty N-terminal CARD domains.", "The predominant localization of Linc00173 is in mononuclear macrophage nuclei.", "Stacking is more stable when a purine is present in the +5 position (C1698)."], "hard_negative": "mcm 5 s 2 U is required for proper decoding of NNR codons in eukaryotes."}
{"query_id": "1391", "query_text": "miR-142-5P is a known regulator of raised body temperature.", "negative": "Lamins are found within the inner layer of the nuclear membrane of all cells.", "negatives": ["Lamins are found within the inner layer of the nuclear membrane of all cells.", "Formation of N-terminal pyroglutamate by glutamine cyclase (GC) competes with NTAQ1 for Nt-Gln substrates.", "Genomic aberrations of metastases provide information for targeted therapy.", "Tonic signaling from the scFv is amplified by MyD88/CD40.", "Formation of N-terminal pyroglutamate by glutamine cyclase (GC) competes with NTAQ1 for Nt-Gln substrates.", "The artifactual C-terminal helix swapping in the StART domain is observed in the Ups1-Mdm35 heterodimer of the StARkin superfamily.", "Adult tissue-resident macrophages are seeded before birth.", "ScPif1p has reduced binding ability to G-rich ssDNA compared to non-G-rich ssDNA.", "Genes involved in pre-mRNA splicing have a significant impact on genome stability.", "Major antigen-induced signals from the T cell receptor and secondary signals from costimulatory receptors are required for T cell activation."], "hard_negatives": ["miR-142-5P is a known regulator of raised body temperature.", "miR-142-5P is a temperature-sensitive microRNA (miRNA).", "miRNAs regulate a unique suite of mRNAs to maintain homeostasis in cells.", "Low expression of miR7a does not repress target genes or exert a biological function in ovaries.", "miRNAs enforce homeostasis by suppressing low-level ''leaky'' transcription.", "Low expression of miR7a does not repress target genes or exert a biological function in testis.", "Ly49Q directs the organization of neutrophil polarization by regulating membrane raft functions.", "The PRDM1 gene, when combined with the PRDM14 gene, plays an important role during primordial germ cell specification.", "Overexpressing Cnp1 N-tail variants exacerbates the temperature-sensitive growth defect of scm3-139.", "Ethanol stress lowers the expression of PSP in bacteria."], "hard_negative": "miR-142-5P is a known regulator of raised body temperature."}
{"query_id": "1392", "query_text": "miR-142-5P is a temperature-sensitive microRNA (miRNA).", "negative": "Antimicrobial agents are less effective due to the pressure of antimicrobial usage.", "negatives": ["Antimicrobial agents are less effective due to the pressure of antimicrobial usage.", "p16INK4A degradation is encoded by CDKN2A.", "Higher plasma levels of I-carnitine, when associated with trimethylamine N-oxide, are negatively correlated with cardiovascular events in humans.", "The appearance of brown-like or beige cells primarily occurs in visceral fat, not subcutaneous fat.", "Replacement of OCT4 and SOX2 genes with GATA3 is not capable of reprogramming human cells.", "5'-nucleotidase metabolizes 6MP.", "The G34R/V mutation creates a hypomethylated phenotype at the H3K36 histone.", "Antidepressants increase the severity of migraines.", "The mean suicide rate in women is lower after miscarriage than live birth.", "Repressing IL-18 has negative effects on atherosclerotic lesion composition and progression."], "hard_negatives": ["miR-142-5P is a temperature-sensitive microRNA (miRNA).", "miR-142-5P is a known regulator of raised body temperature.", "miRNAs regulate a unique suite of mRNAs to maintain homeostasis in cells.", "miRNAs enforce homeostasis by suppressing low-level ''leaky'' transcription.", "Microglia are an innate immune cell type of the peripheral nervous system.", "TNFAIP3 is a glioblastoma tumor suppressor.", "Low expression of miR7a does not repress target genes or exert a biological function in ovaries.", "Microglia are an innate immune cell type of the central nervous system.", "Overexpressing Cnp1 N-tail variants exacerbates the temperature-sensitive growth defect of scm3-139.", "R2D2 stops miRNA production by increasing the selectivity of Dcr2 for long dsRNA."], "hard_negative": "miR-142-5P is a temperature-sensitive microRNA (miRNA)."}
{"query_id": "1393", "query_text": "miRNAs enforce homeostasis by suppressing low-level ''leaky'' transcription.", "negative": "Low nucleosome occupancy correlates with high methylation levels across species.", "negatives": ["Low nucleosome occupancy correlates with high methylation levels across species.", "A high microerythrocyte count protects against severe anemia in homozygous alpha (+)- thalassemia trait subjects.", "HNF4A mutations are associated with macrosomia in infancy.", "Genes regulated by Esrrb transcription factor are sensitive to Mbd3 function.", "Progerin induces premature aging in stem cells.", "NAC inhibits the generation of angiotensin-converting enzyme.", "Rising temperatures caused by global warming lowers the risk of dengue fever transmission.", "The G34R/V mutation creates a hypomethylated phenotype at the H3K36 histone.", "Bariatric surgery reduces postmenopausal breast cancer.", "Antimicrobial agents are less effective due to the pressure of antimicrobial usage."], "hard_negatives": ["miRNAs enforce homeostasis by suppressing low-level ''leaky'' transcription.", "miRNAs regulate a unique suite of mRNAs to maintain homeostasis in cells.", "Low expression of miR7a does not repress target genes or exert a biological function in ovaries.", "Low expression of miR7a does not repress target genes or exert a biological function in testis.", "miR-142-5P is a temperature-sensitive microRNA (miRNA).", "Genes involved in pre-mRNA splicing have a significant impact on genome stability.", "Ly49Q directs the organization of neutrophil polarization by regulating membrane raft functions.", "R2D2 stops miRNA production by increasing the selectivity of Dcr2 for long dsRNA.", "Long - range chromatin interactions regulate transcription.", "Trans-acting factors, such as lncRNAs, influence mRNA translation."], "hard_negative": "miRNAs enforce homeostasis by suppressing low-level ''leaky'' transcription."}
{"query_id": "1394", "query_text": "miRNAs regulate a unique suite of mRNAs to maintain homeostasis in cells.", "negative": "Induced hepatic stem cells possess the potential to differentiate into cholangiocytic cells.", "negatives": ["Induced hepatic stem cells possess the potential to differentiate into cholangiocytic cells.", "Two variants of chromosome 6q21 are associated with radiation therapy-induced second malignancies in pediatric Hodgkin lymphoma patients.", "British female students are bullied more than British male students.", "Physical activity level has no association with the difference in maximal oxygen consumption between black and white youth.", "Mice defective for deoxyribonucleic acid (DNA) polymerase m (polm) fail to reveal increased sensitivity to ionizing radiation (IR).", "Cardiac tissue-resident macrophages directly contribute to electrical activity.", "Charcoal shows no benefit for acute paraquat poisoning.", "Bariatric surgery leads to negative outcomes in mental health.", "Normal expression of RUNX1 causes tumorsupressing effects.", "The combination of physical examinations with C-reactive protein values do not improve the accuracy of radiographic verified pneumonia predictions."], "hard_negatives": ["miRNAs regulate a unique suite of mRNAs to maintain homeostasis in cells.", "miRNAs enforce homeostasis by suppressing low-level ''leaky'' transcription.", "Low expression of miR7a does not repress target genes or exert a biological function in ovaries.", "Low expression of miR7a does not repress target genes or exert a biological function in testis.", "miR-142-5P is a temperature-sensitive microRNA (miRNA).", "Microglia are an innate immune cell type of the central nervous system.", "Genes involved in pre-mRNA splicing have a significant impact on genome stability.", "Lamins are found within the inner layer of the mitochondrial membrane of all cells.", "miR-142-5P is a known regulator of raised body temperature.", "Trans-acting factors, such as lncRNAs, influence mRNA translation."], "hard_negative": "miRNAs regulate a unique suite of mRNAs to maintain homeostasis in cells."}
{"query_id": "1397", "query_text": "p16INK4A degradation is  linked to an abnormal wound response caused by the microinvasive step of advanced Oral Potentially Malignant Lesions (OPMLs).", "negative": "Differentiated E2f-1, -2, -3 TKO cells in the intestine do not exhibit apoptosis.", "negatives": ["Differentiated E2f-1, -2, -3 TKO cells in the intestine do not exhibit apoptosis.", "One in two surgical randomized controlled trials are discontinued early.", "Exposure to fine particulate air pollution is unrelated to anxiety prevalence.", "In rhesus macaques, daily subcutaneous injections of tenofovir protects against rectally transmitted simian-human immunodeficiency virus.", "Immune complex triggered cell death leads to sequestration of oxidized mitochondrial DNA.", "In British Men, haplogroup I increases risk of cardiovascular disease by 50%.", "Phase information is useful for predicting donor-recipient matches in organ transplantation.", "ATM and Rad3 related protein have no role in sensing DNA damage.", "Origin gross domestic product(GDP) is negatively related to dengue virus (DENV-1) diffusion in air traffic shipments.", "CD28 signals regulate trafficking of murine auto-reactive T cells into target tissues."], "hard_negatives": ["p16INK4A degradation is  linked to an abnormal wound response caused by the microinvasive step of advanced Oral Potentially Malignant Lesions (OPMLs).", "p16INK4A degradation is encoded by CDKN2A.", "CDK6 shows impaired binding to loss-of-function variants of p18 INK4C.", "Repressing IL-18 has negative effects on atherosclerotic lesion composition and progression.", "CDK6 shows improved binding to loss-of-function variants of p18 INK4C.", "Mutations in RIM1 decrease levels of IME1 RNA.", "Gpr124 suppresses BBB breakdown in mouse models of ischemic stroke.", "Reduced phosphorylation of PP2A increases HDAC4 dephosphorylation by enhancing PP2A-HDAC4 interaction.", "The NF-\u03baB essential modulator gene induces intestinal inflammation by promoting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death.", "Interleukin-18 plays an important role in the pathogenesis of atherosclerosis."], "hard_negative": "p16INK4A degradation is  linked to an abnormal wound response caused by the microinvasive step of advanced Oral Potentially Malignant Lesions (OPMLs)."}
{"query_id": "1398", "query_text": "p16INK4A degradation is encoded by CDKN2A.", "negative": "Aged patients are more susceptible to ischaemia/reperfusion injury.", "negatives": ["Aged patients are more susceptible to ischaemia/reperfusion injury.", "A diminished ovarian reserve is a very strong indicator of infertility, even in an a priori non-infertile population.", "Omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegans.", "Induced hepatic stem cells possess the potential to differentiate into hepatocytic cells.", "Pure neural progenitor cell (NPC) populations can only be obtained from cell cultures that undergo passaging, filtration, or other isolation and cell sorting methods.", "The peak incidence of fractures occurs in toddlers.", "There is no association between HNF4A mutations and diabetes risks.", "Broadly HIV-1 Neutralizing Antibodies (bnAb) 10EB have no affinity for phospholipids.", "B cells go though plasmablast differentiation and antibody production by continuous expression of EBI2.", "Self-advocacy training is effective at decreasing homelessness."], "hard_negatives": ["p16INK4A degradation is encoded by CDKN2A.", "p16INK4A degradation is  linked to an abnormal wound response caused by the microinvasive step of advanced Oral Potentially Malignant Lesions (OPMLs).", "CDK6 shows impaired binding to loss-of-function variants of p18 INK4C.", "Reduced phosphorylation of PP2A increases HDAC4 dephosphorylation by enhancing PP2A-HDAC4 interaction.", "CDK6 shows improved binding to loss-of-function variants of p18 INK4C.", "Activation of PPM1D enhances p53 function.", "Reduced phosphorylation of PP2A suppresses HDAC4 dephosphorylation.", "NR5A2 is important in reverse cholesterol transport in humans.", "MUC1-C activates the NF-\u03baB p65 signaling pathway by interacting with I\u03baB kinase \u00df.", "Gpr124 suppresses BBB breakdown in mouse models of ischemic stroke."], "hard_negative": "p16INK4A degradation is encoded by CDKN2A."}
{"query_id": "1400", "query_text": "p75 NTR - associated cell death executor (NADE) interacts with the p75 NTR death domain", "negative": "Nigerian physicians constitue the largest component of sub-Saharan Africa-trained physicians in the United States.", "negatives": ["Nigerian physicians constitue the largest component of sub-Saharan Africa-trained physicians in the United States.", "Cancer cells can stimulate the accumulation of intra-tumoural myeloid-derived suppressor cells by promoting granulocyte colony stimulating factor production.", "GATA3 regulates self-renewal capacity in bone marrow hematopoietic stem cells.", "ART has no effect on the infectiveness of HIV-positive people.", "Therapeutics receiving accelerated approval encounter a lower frequency of post-marketing safety events", "Reduced levels of lipolysis leads to higher P38 phosphorylation in adipose tissue.", "Intake of folic acid (FA) and vitamin B6 (VB6) reduces levels of homocysteine.", "Venules have less significant tunica adventitia than arterioles.", "Myelin sheaths are lipid-rich cellular structures.", "In breast cancer, the loss of myoepithelial cells promotes the transition of ductal carcinoma in situ to invasive carcinoma."], "hard_negatives": ["p75 NTR - associated cell death executor (NADE) interacts with the p75 NTR death domain", "Ribosome-inactivating protein-2 (RIP-2) interacts with the p75 NTR death domain", "Guanine nucleotide dissociation inhibitor (Rho-GDI) interacts with the p75 NTR death domain", "Formation of N-terminal pyroglutamate by glutamine cyclase (GC) competes with NTAQ1 for Nt-Gln substrates.", "Binding of p53 to enhancer regions (p53BERs) regulates the activity of p53 transcription and cell cycle arrest through the production of p53-dependent eRNAs.", "ITAM phosphorylation allows for the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).", "Replacement of histone H2A with H2A.Z accelerates gene activation in yeasts by destabilizing +1 nucleosomes.", "Blocking the interaction between TDP-43 and respiratory complex I proteins ND3 and ND6 prevents TDP-43-induced neuronal loss.", "MUC1-C activates the NF-\u03baB p65 signaling pathway by interacting with I\u03baB kinase \u00df.", "5'-nucleotidase metabolizes 6MP."], "hard_negative": "p75 NTR - associated cell death executor (NADE) interacts with the p75 NTR death domain"}
{"query_id": "1401", "query_text": "qSOFA scores are associated with length of stay in emergency department patients.", "negative": "At least 85% of patients exposed to radiation have activated markers of myofibroblasts.", "negatives": ["At least 85% of patients exposed to radiation have activated markers of myofibroblasts.", "Asymptomatic visual impairment screening in elderly populations leads to improved vision.", "MT binding domain drives amyloid structure formation.", "IL-6 signaling plays a major role in atherosclerotic cardiovascular disease.", "Whole brain radiotherapy increases the occurrence of new brain metastases.", "cSMAC formation represses weak ligand signalling.", "The NF-\u03baB essential modulator gene prevents intestinal inflammation by inhibiting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death.", "Lmna knock-in models are appropriate for testing therapeutic approaches against Hutchinson-Gilford progeria syndrome (HGPS).", "Bacterial meningitis can be diagnosed on the basis of positive cerebrospinal fluid (CSF) cultures.", "GATA3 regulates self-renewal capacity in bone marrow hematopoietic stem cells."], "hard_negatives": ["qSOFA scores are associated with length of stay in emergency department patients.", "Cost effectiveness evaluations based on cRCT data accurately reflect prices for patients in actual clinical practice.", "TNFAIP3 is a glioblastoma tumor enhancer.", "Including pharmacists in rounding teams does not alter the incidence of adverse drug events (ADEs).", "TNFAIP3 is a glioblastoma tumor suppressor.", "TNFAIP3 is a tumor enhancer in glioblastoma.", "Increased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm.", "Decreased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm.", "Including pharmacists in rounding teams reduces the incidence of adverse drug events (ADEs).", "Cost effectiveness evaluations based on cRCT data lack external validity."], "hard_negative": "qSOFA scores are associated with length of stay in emergency department patients."}
{"query_id": "1402", "query_text": "r-protein chaperones are found in complexes with their r-protein binding partners.", "negative": "Fibroblast growth factor 21 protects against atherosclerosis by modulating adiponectin and SREBP2 levels.", "negatives": ["Fibroblast growth factor 21 protects against atherosclerosis by modulating adiponectin and SREBP2 levels.", "Cancers that initially benefit from epidermal growth factor receptor targeted therapies later become refractory through several mechanisms.", "Increased LDL receptors plays a role in the reduction of plasma Lp(a).", "Integrated care is successful at tackling multiple comorbidities.", "Patients in stable partnerships progress from HIV to death at the same rate as patients not in partnerships.", "Physical activity does not improve cognitive function in individuals with Alzheimers.", "The appearance of brown-like or beige cells primarily occurs in visceral fat, not subcutaneous fat.", "Bacterial meningitis can be diagnosed on the basis of positive cerebrospinal fluid (CSF) cultures.", "AZT given with ribavirin increases anemia.", "Progerin induces premature aging in stem cells."], "hard_negatives": ["r-protein chaperones are found in complexes with their r-protein binding partners.", "Ribosomopathies have a high degree of cell and tissue specific pathology.", "Sequence conservation in gene regulatory regions between species is a high-accuracy predictor of conserved functionality.", "Sequence conservation in gene regulatory regions between species is a poor predictor of conserved functionality.", "Intramembrane cleavage by signal peptide peptidase aids in the degradation of proteins with a complex membrane orientation.", "Many transmembrane receptors transmit signals by long-range conformational changes in the association of alpha-helices across the plasma membrane.", "miRNAs regulate a unique suite of mRNAs to maintain homeostasis in cells.", "Pre-mRNAs associated with spliceosomal components are more stable than unassociated splicing substrates.", "Pre-mRNAs associated with spliceosomal components are less stable than unassociated splicing substrates.", "mcm 5 s 2 U is required for proper decoding of NNR codons in eukaryotes."], "hard_negative": "r-protein chaperones are found in complexes with their r-protein binding partners."}
{"query_id": "1403", "query_text": "siRNA knockdown of A20 accelerates tumor progression in an in vivo murine xenograft model.", "negative": "Natriuretic peptides increase susceptibility to diabetes.", "negatives": ["Natriuretic peptides increase susceptibility to diabetes.", "Autologous transplantation of mesenchymal stem cells has better graft function than induction therapy with anti-interleukin-2 receptor antibodies.", "Omnivores produce less trimethylamine N-oxide from dietary I-carnitine than vegans.", "\u03b21/Ketel is able to bind microtubules.", "Antidepressants increase the severity of migraines.", "Insulin effects appetite via ventral tegmental neurons.", "Gastric infection with Helicobacter pylori decreases risk of gastric cancer in humans.", "MICAL redox enzymes regulate actin dynamics in many cell types.", "During non-homologous end joining, the ligation step is not as tolerant of disrepairs and other distortions when joining 5' of strand breaks as compared to 3' strand breaks.", "B cells go though plasmablast differentiation and antibody production by continuous expression of EBI2."], "hard_negatives": ["siRNA knockdown of A20 accelerates tumor progression in an in vivo murine xenograft model.", "siRNA knockdown of A20 slows tumor progression in an in vivo murine xenograft model.", "Up-regulation of the p53 pathway and related molecular events speeds cancer progression.", "TNFAIP3 is a glioblastoma tumor suppressor.", "Low expression of miR7a does not repress target genes or exert a biological function in ovaries.", "TNFAIP3 is a tumor enhancer in glioblastoma.", "TNFAIP3 is a glioblastoma tumor enhancer.", "Increased mobility of retrotransposons is assosciated with mutation and higher tumorigenesis rates.", "Increased mobility of retrotransposons does not lead to mutation and higher tumorigenesis rates.", "Increase of p62 in prostate tumor stroma results in defective autophagy."], "hard_negative": "siRNA knockdown of A20 accelerates tumor progression in an in vivo murine xenograft model."}
{"query_id": "1404", "query_text": "siRNA knockdown of A20 slows tumor progression in an in vivo murine xenograft model.", "negative": "Low expression of miR7a does not repress target genes or exert a biological function in ovaries.", "negatives": ["Low expression of miR7a does not repress target genes or exert a biological function in ovaries.", "Upon viral challenge, influenza-specific memory CD4+ T cells greatly enhance the early production of inflammatory chemokines in the lung.", "In chronic viral infections or tumors, peptides that selectively inhibit PTPRS can be utilized to boost insufficient activity of pDCs.", "Roughly 55% of women with chronic pelvic pain have no underlying pathology.", "De novo assembly of sequence data has shorter contigs than unassembled sequence data.", "Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection increases dissemination of Salmonella Typhimurium from the gut.", "The generation of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells.", "Carriers of HNF4A mutations are at reduced risk for diabetes.", "Pseudogene PTENP1 encodes a transcript that regulates PTEN expression.", "L3MBTL2 binds to H2AK119Ub marked chromatin to form a PRC1 complex."], "hard_negatives": ["siRNA knockdown of A20 slows tumor progression in an in vivo murine xenograft model.", "siRNA knockdown of A20 accelerates tumor progression in an in vivo murine xenograft model.", "TNFAIP3 is a glioblastoma tumor suppressor.", "Low expression of miR7a does not repress target genes or exert a biological function in ovaries.", "Up-regulation of the p53 pathway and related molecular events speeds cancer progression.", "TNFAIP3 is a tumor enhancer in glioblastoma.", "TNFAIP3 is a glioblastoma tumor enhancer.", "Increase of p62 in prostate tumor stroma results in defective autophagy.", "ALDH1 expression is associated with poorer prognosis for breast cancer primary tumors.", "Low expression of miR7a does not repress target genes or exert a biological function in testis."], "hard_negative": "siRNA knockdown of A20 slows tumor progression in an in vivo murine xenograft model."}
{"query_id": "1405", "query_text": "taa1 tar1 tar2 triple mutants in Arabidopsis do not make root meristem during embryogenesis.", "negative": "Depletion of nitric oxide is responsible for vasospasm.", "negatives": ["Depletion of nitric oxide is responsible for vasospasm.", "Risedronate increases risk of vertebral and non-vertebral fractures.", "Helicobacter pylori-induced aberrant NF-kB-dependent expression of activation-induced cytidine deaminase contributes to the mutagenesis of host DNA.", "The density of cytokine receptor bearing cells has no effect on the distance over which cytokines act.", "RUNX is not expressed in skin tissue.", "ATM and Rad3 related protein are critical for sensing DNA damage.", "Cell autonomous sex determination in somatic cells occurs in Galliformes.", "Lysine histone demethylase inhibitor JIB 04 is inactive against KDM5A.", "Propriospinal interneurons that play a role in the plastic reorganization of spinal circuits are integral for recovery from spinal cord injury.", "Forkhead 0 (fox0) transcription factors are involved in cellular differentiation."], "hard_negatives": ["taa1 tar1 tar2 triple mutants in Arabidopsis do not make root meristem during embryogenesis.", "Localization of PIN1 in the roots of Arabidopsis requires VPS9a", "Upregulation of PD1 causes the downmodulation of Satb1.", "Removal of H3K9me3 by ectopic expression of other H3K9 demethylases improves reprogramming efficiency in SCNT experiments.", "Removal of H3K9me3 by ectopic expression of other H3K9 demethylases decreases reprogramming efficiency in SCNT experiments.", "YAP/TAZ is required in intestinal regeneration in mouse models of ulcerative colitis.", "MT binding domain drives amyloid structure formation.", "Inhibiting HDAC6 increases survival of mice with ARID1A mutated tumors.", "Activation of the Rac1 homolog CED-10 kills viable cells in SRGP-1 mutant Caenorhabditis elegans.", "ERAP1 SNPs are epistatic to HLA alleles for ankylosing spondylitis."], "hard_negative": "taa1 tar1 tar2 triple mutants in Arabidopsis do not make root meristem during embryogenesis."}
{"query_id": "1406", "query_text": "\u03b2-sheet opening occurs during pleurotolysin pore formation.", "negative": "Varenicline monotherapy is more effective after 26 weeks of treatment compared to combination nicotine replacement therapies with varenicline or bupropion.", "negatives": ["Varenicline monotherapy is more effective after 26 weeks of treatment compared to combination nicotine replacement therapies with varenicline or bupropion.", "DUSP4 increases apoptosis.", "Ultrasound guidance significantly reduces the number of traumatic procedures when attempting needle insertion.", "Monoclonal antibody targeting of N-cadherin inhibits growth.", "LSD1-positive promoters are associated with RNA polymerase II", "Addition of BMP4, activin A, CHIR99021, and SU504 to reprogramming fibroblasts generates, expands and maintains cardiovascular progenitor cells (CPCs)", "In chronic viral infections or tumors, peptides that selectively inhibit PTPRS can be utilized to boost insufficient activity of pDCs.", "Assessing treatment adherence is more beneficial to clinical practice than measuring routine outcomes.", "Environmentally-induced senescence is mimicked in disease modeling by adding specific molecules to the culture system.", "Mutant mice lacking SVCT2 have severely reduced ascorbic acid levels in both brain and adrenals."], "hard_negatives": ["\u03b2-sheet opening occurs during pleurotolysin pore formation.", "VgrG (Tssl) protein punctures membranes by forming a spike at the tip of the tube apparatus.", "Stiff substrates encourage mesodermal differentiation by degrading beta-catenin in an integrin-dependent manner.", "Stiff substrates inhibit mesodermal differentiation by degrading beta-catenin in an integrin-dependent manner.", "Venules have less significant tunica adventitia than arterioles.", "Intramembrane cleavage by signal peptide peptidase aids in the degradation of proteins with a complex membrane orientation.", "The microtubule-dependent delivery and secretion of matrix metalloproteases (MMPs) is partially responsible for the disassembly of adhesion sites.", "\u03b21/Ketel is able to bind microtubules.", "Myelin sheaths are lipid-rich cellular structures.", "The tissue surrounding the granuloma in an immune cell induces an anti-inflammatory immune response."], "hard_negative": "\u03b2-sheet opening occurs during pleurotolysin pore formation."}
{"query_id": "1407", "query_text": "\u03b21/Ketel is able to bind microtubules.", "negative": "Vitamin D deficiency effects birth weight.", "negatives": ["Vitamin D deficiency effects birth weight.", "Tonic signaling from the scFv induces constitutive stimulation.", "Antiretroviral therapy increases rates of tuberculosis across a broad range of CD4 strata.", "Monoclonal antibody targeting of N-cadherin inhibits growth.", "A diminished ovarian reserve is a very strong indicator of infertility, even in an a priori non-infertile population.", "F4/80+ macrophages regulate mature osteoblast maintenance.", "Lack of FGF21 in mice leads to reduced lifespan.", "The tip of the inner tube of the toxic type VI secretion system (T6SS) antibacterial effector in Escherichia coli (E. coli) is decorated with VgrG and PAAR proteins.", "In the UK, drowning affects boys and girls equally.", "Women with a lower birth weight are more likely to develop breast cancer later in life."], "hard_negatives": ["\u03b21/Ketel is able to bind microtubules.", "TMEM27 is a marker for beta cells.", "Myelin sheaths are lipid-rich cellular structures.", "Neutrophils produce IL-1\u03b2 in response to large particles.", "Increased purity of cytoplasmic membranes isolated from overexpressors is indicated by stronger spots for OmpF in 2D BN-PAGE gels.", "Reduction of purity of cytoplasmic membranes isolated from overexpressors is indicated by stronger spots for OmpF in 2D BN-PAGE gels.", "The microtubule-dependent delivery and secretion of matrix metalloproteases (MMPs) is partially responsible for the disassembly of adhesion sites.", "Flexible molecules experience less steric hindrance in the tumor microenviroment than rigid molecules.", "Reduction of purity of cytoplasmic membranes isolated from overexpressors is indicated by stronger spots for OmpA in 2D BN-PAGE gels.", "PrimPol generates short DNA replication intermediates on the leading strand during DNA replication."], "hard_negative": "\u03b21/Ketel is able to bind microtubules."}