Occipital activation levels are associated with auditory spatial performance in parietal regions of the brain.

4-PBA treatment decreases endoplasmic reticulum stress in response to general endoplasmic reticulum stress markers.

Patients with common epithelial cancers are less likely to have an emergency event as their first hospital admission if they live in resource-deprived areas.

Healthy volunteers exhibit rapid and transient increase of cellular ATP after being bolus-injected with fructose.

One in two surgical randomized controlled trials are discontinued early.

Tuberculosis incidence occurs at higher rates in more sparsely populated areas in the UK.

A breast cancer patient's capacity to metabolize tamoxifen influences treatment outcome.

Sudden death can occur in patients with complex ventricular arrhythmias.

PKG-la does not have a large impact on expression of spinal long term potentiation in PGK-la knockout mice.

Headaches are correlated with cognitive impairment.

Hypothalamic glutamate neurotransmission is unrelated to energy balance.

Energy balance requires hypothalamic glutamate neurotransmission.

Insulin effects appetite via ventral tegmental neurons.

The density of cytokine receptor bearing cells affects the distance over which cytokines act.

The cytokine receptor which regulates chemotaxis and formation of lymph nodes is involved in production of myeloperoxidase in the left atrium.

The density of cytokine receptor bearing cells has no effect on the distance over which cytokines act.

Exposure to fine particulate air pollution is unrelated to anxiety prevalence.


Omnivores produce less trimethylamine N-oxide from dietary I-carnitine than vegans.

Drosophila supracellular actomyosin structures are found at boundaries in wing imaginal discs.

ITAM phosphorylation allows for the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).

Natriuretic peptides increase susceptibility to diabetes.

Cancer-associated fibroblasts (CAFs) are constituents of tumor microenvironments

T cell receptor /CD3 microdomains are required to induce the immunologic synapse.

Treatment with a protein named FN impairs regenerative abilities of aged muscles.

A deficiency of vitamin B6 decreases blood levels of homocysteine.

Differentiated E2f-1, -2, -3 TKO cells in the intestine do not exhibit apoptosis.

The DEXI promoter region is bound by multiple transcription factors in a murine haematopoietic progenitor cell line.

Omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegans.

Omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegetarians.

Higher plasma levels of I-carnitine, when associated with trimethylamine N-oxide, are negatively correlated with cardiovascular events in humans.

Higher plasma levels of I-carnitine, when associated with trimethylamine N-oxide, are positively correlated with cardiovascular events in humans.

The most prevalent adverse events to Semaglutide are gastrointestinal.

Sildenafil worsens erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.

Long chain polyunsaturated fatty acids supplementation reduces wheezing and asthma.

Intake of folic acid (FA) and vitamin B6 (VB6) reduces levels of homocysteine.

Female carriers of the Apolipoprotein E4 (APOE4) allele have shorter lifetime exposure to estrogen due to a decreased reproductive period.


Omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegans.

Microglia are an innate immune cell type of the peripheral nervous system.

Replacement of OCT4 and SOX2 genes with GATA3 has the ability to reprogram human cells.

Side effects associated with antidepressants lower risk of myocardial infarction.

Glycan adaptation involves insertion-deletion events.

NAC destabilizes NO to increase the effect of contrast agents on renal functions.

The mean suicide rate in women is lower after miscarriage than live birth.

In the UK, drowning affects boys and girls equally.

Including pharmacists in rounding teams does not alter the incidence of adverse drug events (ADEs).

Ten percent (10%) of kidney cancers in the UK are attributable to excess weight.

Sildenafil worsens erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.

LDL cholesterol has a causal role in the development of cardiovascular disease.


Omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegetarians.

Systemic immunosuppressive (IS) therapy increases the chance of cancer mortality in patients with inflammatory eye disease (IED)

EG7 tumors can be killed by systemic oxaliplatin primed CD8+ T cells from the tumor-draining lymph node cells.

miRNAs enforce homeostasis by suppressing low-level ''leaky'' transcription.

Sympathetic nerve activity is elevated throughout normal pregnancy.

PrimPol degrades short DNA replication intermediates on the leading strand during DNA replication.

Medications to treat obesity are highly effective.

A low percentage of hematopoietic progenitor cells are susceptible to HIV-1 infection ex vivo.

The repeat-variable diresidue (RVD) in the loop of Transcription-Activator Like (TAL) effectors specifies the nucleotides-amino acid contact at the target promoter element.

Reduction of Rpl38 alters the composition of the Hox gene mRNAs translation in mice without lowering overall protein synthesis.

Female carriers of the Apolipoprotein E4 (APOE4) allele have longer lifetime exposure to estrogen due to an increased reproductive period.

Thiopurine active metabolites can be catabolized through dephosphorylation of thioguanine nucleotides.

Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission.


One in five surgical randomized controlled trials are discontinued early.

Induced hepatic stem cells possess the potential to differentiate into cholangiocytic cells.

Mice without IFN-γ or its receptor are highly susceptible to EAM induced with α-MyHC/CFA.

Female carriers of the Apolipoprotein E4 (APOE4) allele have decreased risk for dementia.

Cancer-associated fibroblasts (CAFs) are constituents of tumor microenvironments

MFGE8 regulates fat absorption by binding to av-Beta3 and av-Beta5 integrins.

Klf2 is important for proper myeloid cell function.

MafA ubiquitination decreases the recruitment of coavtivator P/CAF by MafA.

Reduction of purity of cytoplasmic membranes isolated from overexpressors is indicated by stronger spots for OmpA in 2D BN-PAGE gels.

The most prevalent adverse events to Semaglutide are cardiovascular.

In breast cancer, the loss of myoepithelial cells slows the transition of ductal carcinoma in situ to invasive carcinoma.

One in two surgical randomized controlled trials are discontinued early.

32% of liver transplantation programs required patients to discontinue methadone treatment in 2001.

Therapeutics receiving accelerated approval encounter a lower frequency of post-marketing safety events

70% of burn patients are admitted for hospitalization and further treatment after appearing at hospital emergency wards or outpatient clinics.

Risk-adjusted mortality rates are similar in teaching and non-teaching hospitals.

Early patent ductus ateriosus (PDA) screening decreases in-hospital mortality.

90% of patients with melanoma and an objective response to PD-1 blockade will experience a progression in their melanoma.

Early patent ductus ateriosus (PDA) screening increases in-hospital mortality.

1-1% of colorectal cancer patients are diagnosed with regional or distant metastases.


One in two surgical randomized controlled trials are discontinued early.

Omnivores produce less trimethylamine N-oxide from dietary I-carnitine than vegans.

Egr2 regulates the homeostasis of B and T cells.

Tonic signaling from the scFv prevents constitutive stimulation.

Immune complex triggered cell death leads to extracellular release of nuclear DNA.

Students who perform poorly in the early years of medical school are less likely to commit professional misconduct later in their careers.

Combination nicotine replacement therapies with varenicline or bupropion are more effective after 12 weeks of reatment compared to varenicline monotherapy.

Pseudoknots are not evolutionarily conserved in most eukaryotes.

Pioglitazone use is not associated with an increased risk of prostate cancer.

miR-142-5P is a known regulator of raised body temperature.

In patients with congenital heart defects, β-blockers significantly improve clinical heart failure outcomes.


Origin gross domestic product(GDP) is negatively related to dengue virus (DENV-1) diffusion in air traffic shipments.

Certain immunomodulator-human dialyzable leukocyte extract (hDLE) peptides are recognized by toll-like receptors (TLRs) on macrophages and dendritic cells.

70% of burn patients are admitted for hospitalization and further treatment after appearing at hospital emergency wards or outpatient clinics.

RANK-RANKL pathway signalling is linked to development of Aire-expressing medullary thymic epithelial cells.

Broadly HIV-1 Neutralizing Antibodies (bnAb) 10EB have no affinity for phospholipids.

The deregulated and prolonged activation of monocytes improves inflammatory disease outcomes.

Upon viral challenge, influenza-specific memory CD4+ T cells greatly diminish the early production of inflammatory chemokines in the lung.

RTEL1 interacts with TRF2 through a C4C4 motif

Sudden death can occur in patients with orthostatic hypertension without cardiac conduction abnormalities.

Eilat virus (EILV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in nonhuman primates.

MFGE8 regulates fat absorption by binding to av-Beta3 and av-Beta5 integrins.

Origin gross domestic product(GDP) is positively related to dengue virus (DENV-1) diffusion in air traffic shipments.

Destination container port throughput(CPT) is negatively related to dengue virus (DENV-1) diffusion in air traffic shipments.

Destination container port throughput(CPT) is positively related to dengue virus (DENV-1) diffusion in air traffic shipments.

Rising temperatures caused by global warming increases risk of dengue fever transmission.

Urbanization is an important risk factor related to the transmission of dengue fever.

Rising temperatures caused by global warming lowers the risk of dengue fever transmission.

Epidemiological disease burden from noncommunicable diseases is more prevalent in high economic settings.

Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 inhibit West Nile virus replication in cortical neurons.


Origin gross domestic product(GDP) is positively related to dengue virus (DENV-1) diffusion in air traffic shipments.

British female students are bullied more than British male students.

Genes regulated by Esrrb transcription factor are sensitive to Mbd3 function.

Pre-mRNAs associated with spliceosomal components are less stable than unassociated splicing substrates.

Blocking the interaction between TDP-43 and respiratory complex I proteins ND3 and ND6 prevents TDP-43-induced neuronal loss.

32% of liver transplantation programs required patients to discontinue methadone treatment in 2001.

A T helper 2 cell (Th2) environment impedes disease development in patients with systemic lupus erythematosus (SLE).

Omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegetarians.

Localization of PIN1 in the roots of Arabidopsis requires VPS9a

Nonhypertensive people who are 55 years old have a 90% chance of developing hypertension during their lifetime.

Omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegans.

Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 encourage West Nile virus replication in cortical neurons.


Osteocytes have an essential role in G-CSF induced HSPC mobilization.

Lack of FGF21 in mice leads to atherosclerotic plaque formation.

BiP is a general endoplasmic reticulum stress marker.

Students who perform poorly in the early years of medical school are less likely to commit professional misconduct later in their careers.

Smc5/6 engagment halts the activation of SUMO E3 ligase Mms21 by ATP-dependent remolding.

Lamins are associated with nuclear membrane structure maintenance.

Tumor development occurs in conjunction with upregulation of pro-inflammatory cytokines.

10% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.

Activator-inhibitor pairs are provided ventrally by Xrl-sizzled.

Removal of H3K9me3 improves reprogramming efficiency in human somatic cell nuclear transfer experiments.

AZT given with ribavirin increases anemia.

The cytokine receptor which regulates chemotaxis and formation of lymph nodes is involved in production of myeloperoxidase in the left atrium.

F4/80+ macrophages regulate mature osteoblast maintenance.

Cancer-associated fibroblasts (CAFs) interact with cancer cells to mediate formation and activation of CAFs.

Oxidative phosphorylation is one of the primary glycometabolic pathways in cells.

Induced hepatic stem cells possess the potential to differentiate into cholangiocytic cells.

Cancer cells can stimulate the accumulation of intra-tumoural myeloid-derived suppressor cells by promoting granulocyte colony stimulating factor production.

G-CSF increases the expansion and infiltration of MDSCs into tumors.

Cancer-associated fibroblasts (CAFs) have no known interaction with cancer cells in the formation and activation of CAFs.

Klf4 is important for proper myeloid cell differentiation.


Osteoparthritis (OA) is characterized by degeneration of articular cartilage, joint edge, and subchondral bone hyperplasia.

Venules have less significant tunica adventitia than arterioles.

Asymptomatic visual impairment screening in elderly populations leads to improved vision.

Dscam1 acts as a hypervariable pattern-recognition receptor for the immune system.

Pyridostatin encourages proliferation of homologous recombination - defective cells.

Induction of urokinase receptor signaling in podocytes causes foot process effacement and proteinuria.

Suboptimal nutrition is a leading cause of premature death

Helicobacter pylori-induced aberrant NF-kB-dependent expression of activation-induced cytidine deaminase contributes to the mutagenesis of host DNA.

Human embryonic stem cells give rise to cell types from the outer embryonic germ layer, but not the other two layers.

Klf2 is important for proper myeloid cell function.

7-day-old adult Caenorhabditis elegans exhibit approximately 75% of the learning capacity seen in 1-day old adults.

Surgical treatment is not superior to non-surgical in treating adults with displaced fractures of the proximal humerus.

Roughly 55% of women with chronic pelvic pain have no underlying pathology.

Sudden death can occur in patients with orthostatic hypertension without cardiac conduction abnormalities.

Rotator cuff exercises are more effective than general exercise therapy in reducing pain and improving function of the shoulder.

Angiotensin converting enzyme inhibitors are associated with decreased risk for functional renal insufficiency.

Interleukin-18 plays an important role in the pathogenesis of atherosclerosis.

Glioblastoma multiforme (GBM) is characterized by extensive invasion, rapid growth, necrosis, and angiogenesis.

General exercise therapy is more effective than rotator cuff exercises in reducing pain and improving function of the shoulder.


Over half of the gabonese children with Schimmelpenning-Feuerstein-Mims syndrome (SFM) had a plasma lactate of more than 5mmol/L.

Inside the body, falciparum parasites reproduce asexually.

Glycan adaptation involves insertion-deletion events.

Individuals with low serum vitamin D concentrations have decreased risk of multiple sclerosis.

Pioglitazone use is not associated with an increased risk of prostate cancer.

Transplanted human glial progenitor cells can mature in their host animal.

Cancer-associated fibroblasts (CAFs) have no known interaction with cancer cells in the formation and activation of CAFs.

Osteoparthritis (OA) is characterized by degeneration of articular cartilage, joint edge, and subchondral bone hyperplasia.

Removal of H3K9me3 by ectopic expression of other H3K9 demethylases decreases reprogramming efficiency in SCNT experiments.

Ethanol stress reduces the expression of SRL in bacteria.

Ribosome-inactivating protein-2 (RIP-2) interacts with the p75 NTR death domain

Mutant mice lacking SVCT2 have severely reduced ascorbic acid levels in both brain and adrenals.

For every 1,000 children with cerebral palsy, more than 300 of them are premature or underweight at birth.

Patients with microcytosis and higher erythrocyte count were more resistant to severe malarial anaemia when infected with Plasmodium falciparum.

Nonhypertensive people who are 55 years old have a 90% chance of developing hypertension during their lifetime.

There was an estimated 30 million cases of pneumonia in young children worldwide in 2010.

Taxation of sugar-sweetened beverages reduced the incidence rate of type II diabetes in India.

Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission.

Pediatric SCD patients with vaso-occlusive crisis show increased morphine use after breathing 80 ppm iNO for 4 hours.

A T helper 2 cell (Th2) environment impedes disease development in patients with systemic lupus erythematosus (SLE).


Overexpressing Cnp1 N-tail variants exacerbates the temperature-sensitive growth defect of scm3-139.

Medications to treat obesity have unwanted side effects.

Antimicrobial agents are more effective due to the pressure of antimicrobial usage.

The mean suicide rate in women is higher after miscarriage than live birth.

Patients with microcytosis and higher erythrocyte count were more resistant to severe malarial anaemia when infected with Plasmodium falciparum.

CD28 initiates tonic signaling in conventional T cells, which causes an exhaustion phenotype and limited efficiency.

The composition of myosin-II isoform switches from the A isoform to the B isoform during hematopoietic differentiation.

The recruitment of Wdr5 to its target loci depends on Kat8.

Tonic signaling from the scFv is amplified by MyD88/CD40.

MUC1-C activates the NF-κB p65 signaling pathway by interacting with IκB kinase ß.

Mice that lack Interferon-γ or its receptor are highly susceptible to experimental autoimmune myocarditis.

Overexpressing Cnp1 N-tail variants rescues the temperature-sensitive growth defect of scm3-139.

miR-142-5P is a temperature-sensitive microRNA (miRNA).

mcm 5 s 2 U is required for proper decoding of NNR codons in eukaryotes.

Activation of PPM1D enhances p53 function.

miR-142-5P is a known regulator of raised body temperature.

Concentrations of SNV and CNV in stem-cell regulatory elements and binding sites of transcription factors in iPSC-lines are distinct from their founding cells.

The predominant localization of Linc00173 is in mononuclear macrophage nuclei.

There is no known interaction between Pioneer factor OCT3/4 and major chromatin remodeling factors.

Mutations in RIM1 raise levels of IME1 RNA.


Overexpressing Cnp1 N-tail variants rescues the temperature-sensitive growth defect of scm3-139.

Increased mobility of retrotransposons does not lead to mutation and higher tumorigenesis rates.

Lack of FGF21 in mice increases life expectancy.

Genomic aberrations of metastases provide information for targeted therapy.

Splenomegaly is observed in knockin mouse lacking the SHP-2 MAPK pathway.

The PPR MDA5 has twenty N-terminal CARD domains.

Cholesterol loading induces KLF4 expression in VSMCs, resulting in the expression of pro-inflammatory cytokines.

siRNA knockdown of A20 slows tumor progression in an in vivo murine xenograft model.

In domesticated populations of Saccharomyces cerevisiae, segmental aneuploidy is very common.

Monoclonal antibody targeting of N-cadherin encourages metastasis.

During non-homologous end joining, the ligation step is not as tolerant of disrepairs and other distortions when joining 5' of strand breaks as compared to 3' strand breaks.

During non-homologous end joining, the ligation step is not as tolerant of disrepairs and other distortions when joining 3' of strand breaks as compared to 5' strand breaks.


Oxidative DNA damage activates STING signalling.

Weighed food records (WFR) result in high completion since they're cheap to run and impose low participant burden.

Origin gross domestic product(GDP) is positively related to dengue virus (DENV-1) diffusion in air traffic shipments.

A 100g dose of chloroquine chemoprophylactic regimen results in retinal toxicity after 1 year of weekly intake.

ALDH1 expression is associated with poorer prognosis for breast cancer primary tumors.

ScPif1p has reduced binding ability to G-rich ssDNA compared to non-G-rich ssDNA.

Increased lipolysis leads to higher P38 phosphorylation in adipose tissue.

Female carriers of the Apolipoprotein E4 (APOE4) allele have shorter lifetime exposure to estrogen due to a decreased reproductive period.

Upregulation of PD1 causes the downmodulation of Satb1.

Oxidative DNA damage inhibits STING signalling.

IFI16 impedes STING phosphorylation and translocation, resulting in reduced activation of STING.

Immune complex triggered cell death leads to sequestration of oxidized mitochondrial DNA.

Immune complex triggered cell death leads to extracellular release of nuclear DNA.

Neutrophils produce IL-1β in response to large particles.

Eilat virus (EILV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in nonhuman primates.

The deamination of cytidine to uridine on the minus strand of viral DNA can inactivate the viral genome by inducing G-to-A mutations.

Citrullinated proteins externalized in neutrophil extracellular traps act indirectly to perpetuate the inflammatory cycle via induction of autoantibodies.

Citrullinated proteins externalized in neutrophil extracellular traps act indirectly to disrupt the inflammatory cycle.


Oxidative DNA damage inhibits STING signalling.

Intramembrane cleavage by signal peptide peptidase aids in the degradation of proteins with a complex membrane orientation.

Diabetes remission occurs less in people treated with conventional therapy than in people treated with laparoscopic adjustable gastric banding surgery.

MICAL redox enzymes regulate actin dynamics in many cell types.

Allogeneic mechanical circulatory support is not as effective as autologous mechanical circulatory support for treating acute myocardial infarction.

Diabetes remission occurs more in people treated with conventional therapy than in people treated with laparoscopic adjustable gastric banding surgery.

CD44v6 is not associated with constitutive and reprogrammed cancer stem cells driving cancer metastasis.

Normal granulomas form in the presence of TNF in Zebrafish.

The ability of activator E2Fs in preventing cell death is limited to terminally differentiated cells.

Deletion of ATM and Rad3 related protein is not predictive of acute tissue loss.

Nonhuman primates are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.

Mice are incapable of producing neutralizing antibodies in reponse to the Chikungunya virus (CHIKV) produced in mosquitos.


Oxidative phosphorylation is one of the primary glycometabolic pathways in cells.

Bariatric surgery reduces colorectal cancer.

Genomic sequences involved in alternative splicing responsible for Hutchinson-Gilford progeria syndrome (HGPS) are abundant in the ''progerinonly'' allele of Lmna knock-in models.

The DESMOND program caused substantial weight loss in most participants.

Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes fibrosis.

Omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegetarians.

Aged patients are less susceptible to ischaemia/reperfusion injury.

Traditional reviews are biased in their interpretations.

Two variants of chromosome 6q21 are associated with radiation therapy-induced second malignancies in pediatric Hodgkin lymphoma patients.

Consumption of whole fruits increases the risk of type 2 diabetes.

Ethanol stress increases the expression of SRL in bacteria.

Mitochondria play a major role in energy production.

Osteocytes have an essential role in G-CSF induced HSPC mobilization.

Mitochondria play a major role in apoptosis.

Hypothalamic glutamate neurotransmission is unrelated to energy balance.

The Snf1 complex regulates carbon and energy metabolism in baker's yeast (Saccharomyces cerevisiae).

Increased lipolysis leads to higher P38 phosphorylation in adipose tissue.

Energy balance requires hypothalamic glutamate neurotransmission.

Pyridostatin stabilizes the G - quadruplex in the telomeric region.

MICAL redox enzymes regulate actin dynamics in many cell types.


PCSK9 inhibitors decrease plasma Lp(a) levels.

Osteocytes have an essential role in G-CSF induced HSPC mobilization.

Pyridostatin stabilizes the G - quadruplex in the telomeric region.

Ultrasound guidance significantly reduces the number of needle insertion attempts necessary for a given procedure.

Cyclin A2 destruction is necessary to switch from unstable to stable kt-mt attachments in mitosis.

4-PBA treatment raises endoplasmic reticulum stress in response to general endoplasmic reticulum stress markers.

Foxk2 regulates autophagy genes in muscle cells and fibroblast cells.

Moderate consumption of candy and chocolate reduces the risk of cardiovascular disease (CVD).

Rhythmic expression of Cry1 translates directly into a circadian regulation of cAMP signaling in hepatic glucose metabolism.

GATA3 regulates self-renewal capacity in bone marrow hematopoietic stem cells.

Increased LDL receptors plays a role in the reduction of plasma Lp(a).

In melanoma, anti-CTLA-4 treatment reinvigorates exhausted PD-1+Eomes+CD8 T cells.

Inhibiting glucose-6-phospate dehydrogenase improves lipogenesis by deactivating LKB1-AMPK signaling.

In chronic viral infections or tumors, peptides that selectively inhibit PTPRS can be utilized to boost insufficient activity of pDCs.

PKG-la does not have a large impact on expression of pain hypersensitivity in PGK-la knockout mice.

Reduced phosphorylation of PP2A increases HDAC4 dephosphorylation by enhancing PP2A-HDAC4 interaction.

Reduced levels of lipolysis leads to higher P38 phosphorylation in adipose tissue.

Reduced phosphorylation of PP2A suppresses HDAC4 dephosphorylation.

90% of patients with melanoma and an objective response to PD-1 blockade will experience a progression in their melanoma.


PD-1 triggering on monocytes enhances IL-10 production by monocytes.

JMJD6 slows the hydroxylation of C-terminal lysine

Angiotensin converting enzyme inhibitors are associated with decreased risk for functional renal insufficiency.

Reduction of purity of cytoplasmic membranes isolated from overexpressors is indicated by stronger spots for OmpA in 2D BN-PAGE gels.

Replacement of OCT4 and SOX2 genes with GATA3 has the ability to reprogram human cells.

Tonic signaling from the scFv prevents constitutive stimulation.

Retinoic acid receptor-related orphan receptor gamma (RORγ) is a therapeutic target for castration-resistant prostate cancer (CRPC)

Glycan adaptation involves insertion-deletion events.

Omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegans.

Antidepressants increase the severity of migraines.

IL-10 production by monocytes inhibits CD4 + T cell response.

Upregulation of PD1 causes the upregulation of Satb1.

Activated Cdk5 regulates DNA damage-induced neuronal death.

The minor G allele of FOXO3 up-regulates IL-10.

Activation of PPM1D enhances p53 function.

Upregulation of PD1 causes the downmodulation of Satb1.

The deregulated and prolonged activation of monocytes improves inflammatory disease outcomes.

IL-6 signaling plays a major role in atherosclerotic cardiovascular disease.

Repressing IL-18 has negative effects on atherosclerotic lesion composition and progression.


PGE 2 suppresss intestinal tumor growth by altering the expression of tumor suppressing and DNA repair genes.

Bacteriophagaes MS2 and Qβ are members of the Leviviridae.

Egr2 regulates the homeostasis of B and T cells.

Increased vessel density along with a reduction in fibrosis improves the efficacy of chemotherapy treatments.

T cell receptor /CD3 microdomains are required to induce the immunologic synapse.

Asymptomatic visual impairment screening in elderly populations leads to improved vision.

Myelin sheaths play a role in action potential propagation.

Piezo1 channels are sensors for cell migration in epithelial cells.

Vitamin D deficiency effects birth weight.

Lipopolysaccharides have an inflammation independent effect on kidney barrier function.

Increased conversion of PGE 2 to PPARy ligand 15-ket-PGE 2 causes accumulation of PGE.

Decreased conversion of PGE 2 to PPARy ligand 15-ket-PGE 2 causes accumulation of PGE.

Decrease of p62 in prostate tumor stroma results in defective autophagy.

Increase of p62 in prostate tumor stroma results in defective autophagy.

Many cytokines that are produced by cancer cells also contribute to carcinogenesis.

Cancer-associated fibroblasts (CAFs) have no known interaction with cancer cells in the formation and activation of CAFs.

Up-regulation of the p53 pathway and related molecular events speeds cancer progression.


PKG-la does not have a large impact on expression of pain hypersensitivity in PGK-la knockout mice.

Microglia are an innate immune cell type of the central nervous system.

Pyridostatin reduces proliferation of homologous recombination - defective cells.

Forkhead 0 (fox0) transcription factors are involved in apoptosis.

PKG-la does not have a large impact on expression of spinal long term potentiation in PGK-la knockout mice.

Intra-cerebroventricular infusion of amyloid-β oligomers increases expression of fibronectin type-III domain-containing protein 5 mRNA in mice hippocampi.

Monoclonal antibody targeting of N-cadherin inhibits castration resistance.

The PRDM1 gene, when combined with the PRDM14 gene, plays an important role during primordial germ cell specification.

In British Men, haplogroup I increases risk of cardiovascular disease by 50%.

Mutations in RIM1 decrease levels of IME1 RNA.

In domesticated populations of Saccharomyces cerevisiae, segmental aneuploidy is very common.

PKG-la plays an essential role in expression of spinal long term potentiation in PGK-la knockout mice.

The minor G allele of FOXO3 downregulates pro-inflammatory cytokines.

Activation of PPM1D enhances p53 function.

Foxp3 represses the expression of transcriptional regulators implicated in memory T cell development.

Rhythmic expression of Cry1 translates directly into a circadian regulation of cAMP signaling in gluconeogenesis.

PCSK9 inhibitors decrease plasma Lp(a) levels.


PKG-la does not have a large impact on expression of spinal long term potentiation in PGK-la knockout mice.

TNFAIP3 is a tumor enhancer in glioblastoma.

Men are more susceptible to death due to pneumonia when compared to women.

Patients with common epithelial cancers  are more likely to have an emergency event as their first hospital admission if they live in resource-deprived areas.

Activated Cdk5 phosphorylates the ATM protein in response to DNA damage.

Myelin sheaths play a role in action potential propagation.

The DESMOND program demonstrates no significant impact on lifestyles outcomes.

Consumption of whole fruits increases the risk of type 2 diabetes.

BCL-2 promotes the apoptotic effects of c-Myc.

Ca2+ cycling is a UCP1-independent thermogenic mechanism.

Converting apoE4 to apoE3 by gene editing prevents the pathology associated with apoE4 in human iPSCderived neurons.

Foxp3 enables the expression of transcriptional regulators implicated in memory T cell development.

Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes fibrosis.

Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes epithelial damage.

FoxO3a activation in neuronal death is inhibited by reactive oxygen species (ROS).


PKG-la plays an essential role in expression of spinal long term potentiation in PGK-la knockout mice.

Exercise reduces cancer mortality rates among Chinese citizens.

KRT17 modulates the expression of the transcriptional regulator AIRE in diseased epithelia.

Stacking is more stable when a purine is present in the +5 position (C1698).

RAD52 is involved in break-induced DNA replication (BIR).

Increased mobility of retrotransposons is assosciated with mutation and higher tumorigenesis rates.

Citrullinated proteins externalized in neutrophil extracellular traps act indirectly to disrupt the inflammatory cycle.

Mice that lack Interferon-γ or its receptor are highly susceptible to experimental autoimmune myocarditis.

76-85% of people with severe mental disorder receive no treatment in low and middle income countries.

The cytokine receptor which regulates chemotaxis and formation of lymph nodes is involved in production of myeloperoxidase in the left atrium.

Two variants of chromosome 6q21 are associated with radiation therapy-induced second malignancies in pediatric Hodgkin lymphoma patients.


PRC1-bound plasmids sediment at a slower rate in unbound plasmids than in sucrose gradients.

Self-advocacy training is effective at decreasing homelessness.

Sudden death can occur in patients with orthostatic hypertension without cardiac conduction abnormalities.

Medications to treat obesity do not have side effects.

The number of unfertilized oocytes in mated hermaphrodites increases with age.

Intra-cerebroventricular infusion of amyloid-β oligomers reduces expression of fibronectin type-III domain-containing protein 5 mRNA in mice hippocampi.

TRAP+ osteoclasts regulate mature osteoblast maintenance.

A deficiency of folate increases blood levels of homocysteine.

Bariatric surgery reduces colorectal cancer.

Activation of the Rac1 homolog CED-10 kills viable cells in SRGP-1 mutant Caenorhabditis elegans.

Replacement of OCT4 and SOX2 genes with GATA3 is not capable of reprogramming human cells.

L3MBTL2 binds to H2AK119Ub marked chromatin to form a PRC1 complex.

Stiff substrates inhibit mesodermal differentiation by degrading beta-catenin in an integrin-dependent manner.

Lamins have no effect on nuclear membrane structure maintenance.

Increased purity of cytoplasmic membranes isolated from overexpressors is indicated by stronger spots for OmpF in 2D BN-PAGE gels.

Lamins are found within the inner layer of the mitochondrial membrane of all cells.

Lamins are associated with nuclear membrane structure maintenance.

Myelin sheaths are lipid-rich cellular structures.

Stiff substrates encourage mesodermal differentiation by degrading beta-catenin in an integrin-dependent manner.

The predominant localization of Linc00173 is in mononuclear macrophage nuclei.


PTEN is a regulator for the transcriptional activity of SRF

In a naive state, blocking Wingless-Int-1 secretion from mouse embryonic stem cells inhibits self-renewal of the mouse embryonic stem cells.

Diabetic patients with acute coronary syndrome experience decreased short-term and long-term risk for bleeding events.

Lice attenuated SIV vaccines induce a stronger antigen-specific T cell response in lymph node cells.

There was an estimated 30 million cases of pneumonia in young children worldwide in 2010.

Expression of oncolytic virus antigens as peptides makes relapse more likely.

Rapamycin increases the concentration of triacylglycerols in fruit flies.

90% of patients with melanoma and an objective response to PD-1 blockade will experience a progression in their melanoma.

Klf4 is important for proper myeloid cell differentiation.

1 in 5 million in UK have abnormal PrP positivity.

Lamins are associated with nuclear membrane structure maintenance.

Pseudogene PTENP1 encodes a transcript that regulates PTEN expression.

TNFAIP3 is a glioblastoma tumor suppressor.

Binding of p53 to enhancer regions (p53BERs) regulates the activity of p53 transcription and cell cycle arrest through the production of p53-dependent eRNAs.

Fibroblast growth factor 21 protects against atherosclerosis by modulating adiponectin and SREBP2 levels.

TNFAIP3 is a tumor enhancer in glioblastoma.

TNFAIP3 is a glioblastoma tumor enhancer.

Activation of PPM1D enhances p53 function.

KRT17 modulates the expression of the transcriptional regulator AIRE in diseased epithelia.

Foxp3 enables the expression of transcriptional regulators implicated in memory T cell development.


Participants who quit smoking reduce lung cancer risk by approximately 50%.

Adult tissue-resident macrophages are seeded before birth.

In pediatric tissue, most T cells are naive T cell emigrants from the thymus.

Improvements in OER catalysts show stable activity over several hundred hours.

Genes regulated by Esrrb transcription factor are sensitive to Mbd3 function.

DUSP4 downregulation deactivates the Ras-ERK pathway

C2 works synergistically with A-769662 to activate dephosphorylated AMPK.

Microglia are an innate immune cell type of the central nervous system.

Immune responses in immune cells are geographically segregated.

The DESMOND program caused substantial weight loss in most participants.

Citrullinated proteins externalized in neutrophil extracellular traps act indirectly to perpetuate the inflammatory cycle via induction of autoantibodies.

Women with a lower birth weight are more likely to develop breast cancer later in life.

High levels of CRP lead to a higher risk of exacerbations in chronic obstructive pulmonary disease (COPD).

Pioglitazone use is significantly associated with an increased risk of pancreatic cancer.

Exercise reduces cancer mortality rates among Chinese citizens.

The risk of cancer rises with level of alcohol consumption.

Pioglitazone use is not associated with an increased risk of prostate cancer.

Pioglitazone use is significantly associated with an increased risk of prostate cancer.

Exercise increases cancer mortality rates among Chinese citizens.

In young and middle-aged adults, current or remote uses of ADHD medications increase the risk of serious cardiovascular events.


Patients in stable partnerships have a slower progression from HIV to AIDS.

Self-advocacy training is effective at decreasing homelessness.

The Snf1 complex regulates carbon and energy metabolism in baker's yeast (Saccharomyces cerevisiae).

Environmentally-induced senescence is mimicked in disease modeling by adding specific molecules to the culture system.

Long chain polyunsaturated fatty acids supplementation is associated with lower rates of atopic eczema at 1 year.

Activated Cdk5 phosphorylates the ATM protein in response to DNA damage.

Homozygous deletion of murine Sbds gene from osterix-expressing mesenchymal stem and progenitor cells (MPCs) induces oxidative stress.

Foxp3 enables the expression of transcriptional regulators implicated in memory T cell development.

Risk-adjusted mortality rates are similar in teaching and non-teaching hospitals.

Overexpressing Cnp1 N-tail variants rescues the temperature-sensitive growth defect of scm3-139.

The effect of Lipopolysaccharides on kidney barrier function is dependent on inflammation levels.

Patients in stable partnerships progress from HIV to death at the same rate as patients not in partnerships.

Having a main partner worsens HIV outcomes.

Having a main partner improves HIV outcomes.

Exhaustion of B cells contributes to poor Ab response in HIV-infected individuals.

ART has no effect on the infectiveness of HIV-positive people.

Chronic HIV stimulation of B cells leads to the premature exhaustion of B cells.

Antiretroviral therapy increases rates of tuberculosis across a broad range of CD4 strata.

ART substantially reduces infectiveness of HIV-positive people.

A low percentage of hematopoietic progenitor cells are susceptible to HIV-1 infection ex vivo.


Patients in stable partnerships progress from HIV to death at the same rate as patients not in partnerships.

Differentiation of progenitor cells to myeloid cells is skewed upon activation of insulin signaling.

Taking 400mg of α-tocopheryl acetate in combination with vitamin C reduces the risk of prostate cancer.

Women are more susceptible to death due to pneumonia when compared to men.

In chronic viral infections or tumors, peptides that selectively inhibit PTPRS can be utilized to boost insufficient activity of pDCs.

Comparative transcriptome analysis identified new platelet proteins with structural features suggesting a role in platelet function.

The DdrB protein from Deinococcus radiodurans functions as a pentamer.

Venules have less significant tunica adventitia than arterioles.

A single nucleotide variant the gene DGKK is strongly associated with increased risk of hypospadias.

Lamins are associated with nuclear membrane structure maintenance.

Sympathetic nerve activity is reduced throughout normal pregnancy.

The mean suicide rate in women is lower after miscarriage than live birth.

Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission.


Patients with common epithelial cancers  are more likely to have an emergency event as their first hospital admission if they live in resource-deprived areas.

Antidepressants reduce the severity of migraines.

There is no increased risk of hypospadias with clomiphene.

There is no association between HNF4A mutations and diabetes risks.

Long chain polyunsaturated fatty acids supplementation has no significant effects on wheezing or asthma at 3 and 6 years.

The Snf1 complex regulates carbon and energy metabolism in baker's yeast (Saccharomyces cerevisiae).

Urbanization is an important risk factor related to the transmission of dengue fever.

Activated Cdk5 regulates DNA damage-induced neuronal death.

Localization of PIN1 in the roots of Arabidopsis requires VPS9a

Overexpressing Cnp1 N-tail variants rescues the temperature-sensitive growth defect of scm3-139.

Pediatric SCD patients with vaso-occlusive crisis show increased morphine use after breathing 80 ppm iNO for 4 hours.

Patients with common epithelial cancers are less likely to have an emergency event as their first hospital admission if they live in resource-deprived areas.

70% of burn patients are admitted for hospitalization and further treatment after appearing at hospital emergency wards or outpatient clinics.

Women with a lower birth weight are more likely to develop breast cancer later in life.

Tuberculosis incidence occurs at higher rates in more sparsely populated areas in the UK.

Ten percent (10%) of kidney cancers in the UK are attributable to excess weight.

1-1% of colorectal cancer patients are diagnosed with regional or distant metastases.

In breast cancer, the loss of myoepithelial cells promotes the transition of ductal carcinoma in situ to invasive carcinoma.

In breast cancer, the loss of myoepithelial cells slows the transition of ductal carcinoma in situ to invasive carcinoma.

Nonhypertensive people who are 55 years old have a 90% chance of developing hypertension during their lifetime.


Patients with common epithelial cancers are less likely to have an emergency event as their first hospital admission if they live in resource-deprived areas.

Ly6C hi monocytes have a higher inflammatory capacity than Ly6C lo monocytes.

mcm 5 s 2 U is required for proper decoding of NNR codons in eukaryotes.

The combination of physical examinations with C-reactive protein values do not improve the accuracy of radiographic verified pneumonia predictions.

CD44v6 is not associated with constitutive and reprogrammed cancer stem cells driving cancer metastasis.

Cholesterol loading induces KLF4 expression in VSMCs, resulting in the expression of pro-inflammatory cytokines.

A 100g dose of chloroquine chemoprophylactic regimen results in retinal toxicity after 1 year of weekly intake.

Intake of folic acid (FA) and vitamin B6 (VB6) increases levels of homocysteine.

The minor G allele of FOXO3 up-regulates IL-10.

Vitamin D is an important factor in the relationship between calcium and parathyroid hormone.

Algerian physicians constitue the largest component of sub-Saharan Africa-trained physicians in the United States.

Risk-adjusted mortality rates are similar in teaching and non-teaching hospitals.


Patients with microcytosis and higher erythrocyte count are more vulnerable to severe malarial anaemia when infected with Plasmodium falciparum.

Trans-acting factors, such as lncRNAs, influence mRNA translation.

The risk of breast cancer among parous women decreases with placental weight of pregnancies.

Treatment with a protein named FN restores regenerative abilities of aged muscles.

Exposure to fine particulate air pollution is unrelated to anxiety prevalence.

Aggravated inflammation is dependent on NLRP3 inflammasome activation.

Hematopoietic Stem Cell purification reaches purity rates above 90%.

T cell receptor /CD3 microdomains are required to induce the immunologic synapse.

Destination container port throughput(CPT) is positively related to dengue virus (DENV-1) diffusion in air traffic shipments.

Helicobacter pylori-induced aberrant NF-kB-dependent expression of activation-induced cytidine deaminase contributes to the mutagenesis of host DNA.

0-dimensional biomaterials lack inductive properties.

Patients with microcytosis and higher erythrocyte count were more resistant to severe malarial anaemia when infected with Plasmodium falciparum.

The most prevalent adverse events to Semaglutide are gastrointestinal.

Nonhuman primates are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.

Women are more susceptible to death due to pneumonia when compared to men.

Stroke patients with prior use of direct oral anticoagulants have a higher risk of in-hospital mortality than stroke patients with prior use of warfarin.

Individuals with low serum vitamin D concentrations have decreased risk of multiple sclerosis.


Patients with microcytosis and higher erythrocyte count were more resistant to severe malarial anaemia when infected with Plasmodium falciparum.

Crossover hot spots are found within gene promoters in Saccharomyces cerevisiae.

Deltex has no known interactions with eIF3f.

Lack of FGF21 in mice leads to reduced lifespan.

Sequence conservation in gene regulatory regions between species is a high-accuracy predictor of conserved functionality.

Side effects associated with antidepressants increases risk of stroke.

Stiff substrates inhibit mesodermal differentiation by degrading beta-catenin in an integrin-dependent manner.

Charcoal is an effective treatment for acute paraquat poisoning.

Systemic immunosuppressive (IS) therapy increases the chance of cancer mortality in patients with inflammatory eye disease (IED)

Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission.

The deamination of cytidine to uridine on the minus strand of viral DNA can inactivate the viral genome by inducing G-to-A mutations.

Eilat virus (EILV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in nonhuman primates.


Patients with panic anxiety show decreased CSF levels of hypocretin.

Monoclonal antibody targeting of N-cadherin encourages metastasis.

Elevated cell-free mitochondrial DNA levels are associated with mortality.

Pharmacist attendance at ward rounds reduces adverse events in wards.

Chlamydia trachomatis is most prevalent in the UK among sexually-experienced individuals aged 16 to 24.

It is not proven that moderate consumption of candy and chocolate reduces the risk of cardiovascular disease (CVD) specifically.

The proliferative capacity of progenitors is regulated cell-autonomously.

aPKCz causes tumour suppression by affecting glutamine metabolism.

There is a relation between Erythromycin use and hypertrophic pyloric stenosis.

Antidepressants increase the severity of migraines.

Hypocretin neurones suppress panicprone state in rats.

Antidepressants reduce the severity of migraines.

Headaches are correlated with cognitive impairment.

Side effects associated with antidepressants increases risk of stroke.

Exposure to fine particulate air pollution is unrelated to anxiety prevalence.

In young and middle-aged adults, current or remote uses of ADHD medications increase the risk of serious cardiovascular events.

Side effects associated with antidepressants lower risk of myocardial infarction.

Side effects associated with antidepressants do not represent a mortality risk to postmenopausal women.


Pediatric SCD patients with vaso-occlusive crisis show increased morphine use after breathing 80 ppm iNO for 4 hours.

Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection increases dissemination of Salmonella Typhimurium from the gut.

MFGE8 regulates fat absorption by binding to av-Beta3 and av-Beta5 integrins.

Gpr124 increases BBB breakdown in mouse models of ischemic stroke.

Cyclin A2 destruction is necessary to switch from unstable to stable kt-mt attachments in mitosis.

Incidence of sepsis has fallen substantially from 2009 to 2014.

Klf4 is not required for proper myeloid cell differentiation.

The US health care system can save up to $5 billion if 7% of patients waiting for kidney transplants participate in the optimized national kidney paired donation program.

Decrease of p62 in prostate tumor stroma results in defective autophagy.

There is no increased risk of hypospadias with clomiphene.

MafA phosphorylation enhances its ubiquitination.

High levels of CRP lead to a higher risk of exacerbations in chronic obstructive pulmonary disease (COPD).

Varenicline monotherapy is more effective after 26 weeks of treatment compared to combination nicotine replacement therapies with varenicline or bupropion.

Combination nicotine replacement therapies with varenicline or bupropion are more effective after 12 weeks of reatment compared to varenicline monotherapy.


Perigenital skin is not the primary site of HIV acquisition.

Replacement of histone H2A with H2A.Z accelerates gene activation in yeasts by destabilizing +1 nucleosomes.

VgrG (Tssl) protein punctures membranes by forming a spike at the tip of the tube apparatus.

Exercise reduces cancer mortality rates among Chinese citizens.

Low nucleosome occupancy correlates with high methylation levels across species.

Bariatric surgery leads to negative outcomes in mental health.

Venules have less significant tunica adventitia than arterioles.

Bariatric surgery reduces colorectal cancer.

A deficiency of vitamin B6 decreases blood levels of homocysteine.

Pro-inflammatory cytokines are up regulated during tumor development.

The risk of cancer rises with level of alcohol consumption.

A low percentage of hematopoietic progenitor cells are susceptible to HIV-1 infection ex vivo.

ART has no effect on the infectiveness of HIV-positive people.

ART substantially reduces infectiveness of HIV-positive people.

Urbanization is an important risk factor related to the transmission of dengue fever.

Chronic HIV stimulation of B cells leads to the premature exhaustion of B cells.

The HSV-2 infection is typically asymptomatic.

Patients in stable partnerships have a slower progression from HIV to AIDS.

Repressing IL-18 has negative effects on atherosclerotic lesion composition and progression.

Chlamydia trachomatis is most prevalent in the UK among sexually-experienced individuals aged 16 to 24.


Peroxynitrite is required for induction of T cell tolerance.

Rising temperatures caused by global warming lowers the risk of dengue fever transmission.

Higher plasma levels of I-carnitine, when associated with trimethylamine N-oxide, are negatively correlated with cardiovascular events in humans.

Human embryonic stem cells give rise to cell types from all three embryonic germ layers.

61% of colorectal cancer patients are diagnosed with regional or distant metastases.

Misunderstandings between doctors and patients can lead to non-adherence.

Including pharmacists in rounding teams reduces the incidence of adverse drug events (ADEs).

ATF4 is a general endoplasmic reticulum stress marker.

Cis-acting lncRNAs control the expression of genes that are positioned in the vicinity of their transcription sites.

Diabetes remission occurs less in people treated with conventional therapy than in people treated with laparoscopic adjustable gastric banding surgery.

Aged patients are more susceptible to ischaemia/reperfusion injury.

Major antigen-induced signals from the T cell receptor and secondary signals from costimulatory receptors are required for T cell activation.

CD28 initiates tonic signaling in conventional T cells, which causes an exhaustion phenotype and limited efficiency.

IL-10 production by monocytes inhibits CD4 + T cell response.

Type 1 Diabetes is associated with subtle perturbations in T reg development.

ITAM phosphorylation allows for the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).

CD28 signals regulate trafficking of murine auto-reactive T cells into target tissues.

Reduced responsiveness to interleukin-2 in regulatory T cells is associated with autoimmune diseases such as Type 1 Diabetes.

T cell receptor /CD3 microdomains are required to induce the immunologic synapse.

Egr2 regulates the homeostasis of B and T cells.


Persister cells provide relapse resistance in cancer patients.

Low expression of miR7a does not repress target genes or exert a biological function in testis.

Dscam1 acts as a hypervariable pattern-recognition receptor for the immune system.

Primary cervical cancer screening with HPV detection has lower longitudinal sensitivity than conventional cytology to detect cervical intraepithelial neoplasia grade 2.

Ca2+ cycling controls whole-body energy homeostasis in beige fat.

Sudden death can occur in patients with complex ventricular arrhythmias.

Increased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm.

Bone marrow cells don't contribute to adult macrophage compartments.

Blocking the interaction between TDP-43 and respiratory complex I proteins ND3 and ND6 prevents TDP-43-induced neuronal loss.

Neutrophil extracellular trap (NET) antigens may contain the targeted autoantigens PR3 and MPO.

Persistor cells are one reason for incomplete responses to Tyrosine kinase inhibitor (TKI) therapy in cancer patients.

Cancer-associated fibroblasts (CAFs) have no known interaction with cancer cells in the formation and activation of CAFs.

Cancer-associated fibroblasts (CAFs) interact with cancer cells to mediate formation and activation of CAFs.

Up-regulation of the p53 pathway and related molecular events speeds cancer progression.

Cancer-associated fibroblasts (CAFs) are constituents of tumor microenvironments

Cancer cells can stimulate the accumulation of intra-tumoural myeloid-derived suppressor cells by promoting granulocyte colony stimulating factor production.

Cancers that initially benefit from epidermal growth factor receptor targeted therapies later become refractory through several mechanisms.

MEK inhibitors are effective treatments in RAS-driven mouse models of cancer.

In breast cancer, the loss of myoepithelial cells promotes the transition of ductal carcinoma in situ to invasive carcinoma.


Persistor cells are one reason for incomplete responses to Tyrosine kinase inhibitor (TKI) therapy in cancer patients.

CD28 signals regulate trafficking of murine auto-reactive T cells into target tissues.

Ca2+ cycling is a UCP1-independent thermogenic mechanism.

Genomic aberrations of metastases provide information for targeted therapy.

Noninvasive positive pressure ventilation is not predictive of acute respiratory failure after solid organ transplantation.

Tuberculosis incidence occurs at higher rates in more sparsely populated areas in the UK.

N348I mutations reduce resistance to nevirapine.

The Snf1 complex regulates carbon and energy metabolism in baker's yeast (Saccharomyces cerevisiae).

Chenodeoxycholic acid treatment increases brown adipose tissue activity.

Klf4 is important for proper myeloid cell differentiation.

CD28 initiates tonic signaling in conventional T cells, which causes an exhaustion phenotype and limited efficiency.

In breast cancer, the loss of myoepithelial cells slows the transition of ductal carcinoma in situ to invasive carcinoma.

In melanoma, anti-CTLA-4 treatment reinvigorates exhausted PD-1+Eomes+CD8 T cells.

Deletion of ATM and Rad3 related protein is not predictive of acute tissue loss.

90% of patients with melanoma and an objective response to PD-1 blockade will experience a progression in their melanoma.


Pharmacist attendance at ward rounds increases adverse events in wards.

A deficiency of folate increases blood levels of homocysteine.

During the primary early antibody response activated B cells migrate toward the inner-and outer follicular areas where oxysterol accumulation is generated by stromal cells.

Origin gross domestic product(GDP) is positively related to dengue virus (DENV-1) diffusion in air traffic shipments.

Less than 10% of patients exposed to radiation have activated markers of mesenchymal stem cells.

0-dimensional biomaterials lack inductive properties.

There is no increased risk of hypospadias with clomiphene.

Glucose restriction to 0.05% reduces RLS (replicative life span) by 20-40% in S. cerevisiae.

ART substantially reduces infectiveness of HIV-positive people.

miR-142-5P is a known regulator of raised body temperature.

Cellular clocks are not predictive of mitosis timing in NIH 3T3 cells.

Pharmacist attendance at ward rounds reduces adverse events in wards.

Including pharmacists in rounding teams does not alter the incidence of adverse drug events (ADEs).

Including pharmacists in rounding teams reduces the incidence of adverse drug events (ADEs).

In young and middle-aged adults, current or remote uses of ADHD medications increase the risk of serious cardiovascular events.

Cost effectiveness evaluations based on cRCT data accurately reflect prices for patients in actual clinical practice.

Risk of cardiovascular events can be cut by a third by using antihypertensive drug therapy among hemodialysis patients.

Side effects associated with antidepressants lower risk of myocardial infarction.

Assessing treatment adherence is more beneficial to clinical practice than measuring routine outcomes.

Measuring routine outcomes is more beneficial to clinical practice than assessing treatment adherence.


Pharmacist attendance at ward rounds reduces adverse events in wards.

Radioiodine treatment of non-toxic multinodular goitre increases thyroid volume.

Antidepressants reduce the severity of migraines.

VgrG (Tssl) protein punctures membranes by forming a spike at the tip of the tube apparatus.

H4 G94P proteins inhibit chromatin assembly, which decreases free histones.

Ribosome-inactivating protein-2 (RIP-2) interacts with the p75 NTR death domain

Walking in traffic areas in London did not improve lung function in elderly adults.

miRNAs regulate a unique suite of mRNAs to maintain homeostasis in cells.

Adult tissue-resident macrophages are seeded before birth.

Vitamin D is an important factor in the relationship between calcium and parathyroid hormone.

Phase information is useful for predicting donor-recipient matches in organ transplantation.


Phase information is useful for predicting donor-recipient matches in organ transplantation.

Therapeutics receiving accelerated approval encounter a lower frequency of post-marketing safety events

4-PBA treatment decreases endoplasmic reticulum stress in response to general endoplasmic reticulum stress markers.

Cost effectiveness evaluations based on cRCT data lack external validity.

In rhesus macaques, daily subcutaneous injections of emtricitabine are ineffective at protecting against rectally transmitted simian-human immunodeficiency virus.

Amitriptyline is an effective treatment for chronic tension-type headaches.

Pyridostatin prevents double-strand breaks accumulation.

Tonic signaling from the scFv prevents constitutive stimulation.

The RANK-RANK-Ligand (RANKL) pathway is involved in the development of Aire-expressing medullary thymic epithelial cells (mTECs).

Mice defective for deoxyribonucleic acid (DNA) polymerase m (polm) fail to reveal increased sensitivity to ionizing radiation (IR).

Long - range chromatin interactions regulate transcription.

Cellular clocks are not predictive of mitosis timing in NIH 3T3 cells.

Sudden death can occur in patients with complex ventricular arrhythmias.

The composition of myosin-II isoform switches from the A isoform to the B isoform during hematopoietic differentiation.

Cellular clocks are associated with mitosis timing in NIH 3T3 cells.

Genomic aberrations of metastases provide information for targeted therapy.

Ultrasound guidance significantly reduces the number of needle insertion attempts necessary for a given procedure.

Noninvasive positive pressure ventilation is not predictive of acute respiratory failure after solid organ transplantation.

Major antigen-induced signals from the T cell receptor and secondary signals from costimulatory receptors are required for T cell activation.


Physical activity does not improve cognitive function in individuals with Alzheimers.

Repressing IL-18 has negative effects on atherosclerotic lesion composition and progression.

Mice defective for deoxyribonucleic acid (DNA) polymerase m (polm) reveal increased sensitivity to ionizing radiation (IR).

MT binding domain drives amyloid structure formation.

Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 encourage West Nile virus replication in cortical neurons.

Ethanol stress increases the expression of SRL in bacteria.

RA activation of DIF2 and NB4 cells induces hallmarks of transcriptionally active promoters.

Urbanization is an important risk factor related to the transmission of dengue fever.

The US health care system can save up to $5 billion if 7% of patients waiting for kidney transplants participate in the optimized national kidney paired donation program.

Deletion of ATM and Rad3 related protein leads to acute tissue loss.

Sympathetic nerve activity is elevated throughout normal pregnancy.

Individuals with Alzheimers who participate in six months of physical activity improve cognitive function for up to 18 months.

Headaches are correlated with cognitive impairment.

Asymptomatic visual impairment screening in elderly populations leads to improved vision.

Female carriers of the Apolipoprotein E4 (APOE4) allele have increased risk for Alzheimer's disease.

In young and middle-aged adults, current or remote uses of ADHD medications increase the risk of serious cardiovascular events.

Incidence of 10/66 dementia is lower than the incidence of DSM-IV dementia.

Incidence of 10/66 dementia is higher than the incidence of DSM-IV dementia.

Medications to treat obesity do not have side effects.

Female carriers of the Apolipoprotein E4 (APOE4) allele have decreased risk for dementia.


Physical activity level has no association with the difference in maximal oxygen consumption between black and white youth.

Low nucleosome occupancy correlates with high methylation levels across species.

Bariatric surgery reduces colorectal cancer.

Having a main partner improves HIV outcomes.

Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission.

Cancer-associated fibroblasts (CAFs) have no known interaction with cancer cells in the formation and activation of CAFs.

Charcoal shows no benefit for acute paraquat poisoning.

Beta-band coherence is enhanced for visible stimuli over invisible stimuli.

The DEXI promoter region is bound by multiple transcription factors in a murine haematopoietic progenitor cell line.

Physical activity level is associated with the difference in maximal oxygen consumption between black and white youth.

The morphology change from large white adipocytes to small brown adipocytes is a sign of decreased energy expenditure potential in white adipose tissue.

The morphology change from large white adipocytes to small brown adipocytes is a sign of increased energy expenditure potential in white adipose tissue.

Participants who quit smoking reduce lung cancer risk by approximately 50%.

Walking in traffic areas in London did not improve lung function in elderly adults.

Walking in traffic areas in London improves lung function in elderly adults.

Hypothalamic glutamate neurotransmission is unrelated to energy balance.

Excess gestational weight gain is associated with obesity-related pregnancy outcomes.

Energy balance requires hypothalamic glutamate neurotransmission.


Physical activity level is associated with the difference in maximal oxygen consumption between black and white youth.

For every 1,000 children with cerebral palsy, more than 300 of them are premature or underweight at birth.

Participants who quit smoking reduce lung cancer risk by approximately 50%.

Mutations in RIM1 decrease levels of IME1 RNA.

Antimicrobial agents are more effective due to the pressure of antimicrobial usage.

NR5A2 is important in reverse cholesterol transport in humans.

Pyridostatin induces double-strand breaks accumulation.

Stiff substrates inhibit mesodermal differentiation by degrading beta-catenin in an integrin-dependent manner.

Measuring routine outcomes is more beneficial to clinical practice than assessing treatment adherence.

HbA1c consistently overestimates glycemic control in black individuals with Sickle cell trait (SCT).

Exposure to fine particulate air pollution is unrelated to anxiety prevalence.


Physical injury represses transgultaminase activity.

Chinese individuals with TT homozygosity in the MTHFR gene are more vulnerable to strokes caused by low levels of folate intake.

Cardiac tissue-resident macrophages directly contribute to electrical activity.

In pediatric tissue, most T cells are naive T cell emigrants from the thymus.

Deltex interacts with eIF3. There is no known interaction between Deltex and elF3

Microglia are an innate immune cell type of the central nervous system.

Emodin forms hydrogen bonds with residues involved in PGAM1 substrate binding.

Walking in traffic areas in London did not improve lung function in elderly adults.

Replacement of histone H2A with H2A.Z accelerates gene activation in yeasts by destabilizing +1 nucleosomes.

p16INK4A degradation is  linked to an abnormal wound response caused by the microinvasive step of advanced Oral Potentially Malignant Lesions (OPMLs).

Chemical injury represses transglutaminase 2 activity.

Neutrophils produce IL-1β in response to large particles.

Side effects associated with antidepressants increases risk of stroke.

Autophagy deficiency in the liver increases vulnerability to insulin resistance.

Oxidative phosphorylation is one of the primary glycometabolic pathways in cells.

Intramembrane cleavage by signal peptide peptidase aids in the degradation of proteins with a complex membrane orientation.

Activated Cdk5 regulates DNA damage-induced neuronal death.

Reduced levels of lipolysis leads to higher P38 phosphorylation in adipose tissue.

Formation of N-terminal pyroglutamate by glutamine cyclase (GC) competes with NTAQ1 for Nt-Gln substrates.


Piezo1 channels are sensors for cell migration in epithelial cells.

PrimPol degrades short DNA replication intermediates on the leading strand during DNA replication.

Insulin effects appetite via ventral tegmental neurons.

There is no known interaction between Pioneer factor OCT3/4 and major chromatin remodeling factors.

Oxidative DNA damage activates STING signalling.

Physical injury represses transgultaminase activity.

Distant CREs are important for transcriptional regulation.

Consumption of whole fruits increases the risk of type 2 diabetes.

The Snf1 complex regulates carbon and energy metabolism in baker's yeast (Saccharomyces cerevisiae).

Higher plasma levels of I-carnitine, when associated with trimethylamine N-oxide, are positively correlated with cardiovascular events in humans.

Increased conversion of PGE 2 to PPARy ligand 15-ket-PGE 2 causes accumulation of PGE.

MeCP2 influences the synaptic maturation of neurons.

Differentiation of progenitor cells to myeloid cells is skewed upon activation of insulin signaling.

Forkhead 0 (fox0) transcription factors are involved in cellular differentiation.

Myelin sheaths are lipid-rich cellular structures.

VgrG (Tssl) protein punctures membranes by forming a spike at the tip of the tube apparatus.

Differentiation of progenitor cells to myeloid cells is skewed when insulin signaling is suppressed.

The cytokine receptor which regulates chemotaxis and formation of lymph nodes is involved in production of myeloperoxidase in the left atrium.


Pioglitazone use is not associated with an increased risk of prostate cancer.

The minor G allele of FOXO3 up-regulates IL-10.

Enhanced early production of inflammatory chemokines damages viral control in the lung.

Ly49Q directs the organization of neutrophil polarization by regulating membrane raft functions.

Mitochondria play a major role in energy production.

Risk of cardiovascular events can be cut by a third by using antihypertensive drug therapy among hemodialysis patients.

RANK-RANKL pathway signalling has no known association with development of Aire-expressing medullary thymic epithelial cells.

53% of perinatal mortality is due to low birth weight.

Upregulation of dynein in Drosophila neurons increases the number of microtubule plus-ends growing toward the cell body of each neuron.

Inhibiting HDAC6 increases survival of mice with ARID1A mutated tumors.

H4 G94P proteins induce chromatin assembly, which increases free histones.

Pioglitazone use is significantly associated with an increased risk of prostate cancer.

Pioglitazone use is significantly associated with an increased risk of pancreatic cancer.

Sildenafil worsens erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.

Taking 400mg of α-tocopheryl acetate does not prevent prostate cancer.

Taking 400mg of α-tocopheryl acetate in combination with vitamin C reduces the risk of prostate cancer.

Side effects associated with antidepressants do not represent a mortality risk to postmenopausal women.

Side effects associated with antidepressants increases risk of stroke.

A breast cancer patient's capacity to metabolize tamoxifen influences treatment outcome.

Side effects associated with antidepressants lower risk of myocardial infarction.


Pioglitazone use is significantly associated with an increased risk of pancreatic cancer.

The morphology change from large white adipocytes to small brown adipocytes is a sign of increased energy expenditure potential in white adipose tissue.

Sildenafil worsens erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.

Deltex interacts with eIF3. There is no known interaction between Deltex and elF3

Tuberculosis incidence occurs at higher rates in more sparsely populated areas in the UK.

The PDPN gene deactivates the C-type lectin receptor (CLEC-2).

Stiff substrates encourage mesodermal differentiation by degrading beta-catenin in an integrin-dependent manner.

Transcription factor EB induces transcription of pro-inflammatory cytokines in macrophages infected with Staphylococcus aureus.

Sweet taste receptors on the tongue are deactivated by between 1 and 10 mM glucose.

Induced hepatic stem cells possess the potential to differentiate into hepatocytic cells.

YAP/TAZ is required in intestinal regeneration in mouse models of ulcerative colitis.


Pioglitazone use is significantly associated with an increased risk of prostate cancer.

Deltex interacts with eIF3. There is no known interaction between Deltex and elF3

r-protein chaperones are found in complexes with their r-protein binding partners.

90% of patients with melanoma and an objective response to PD-1 blockade will experience a progression in their melanoma.

The latent infection of myeloid cells with human cytomegalovirus induces a number of changes in gene expression.

Lamins are found within the inner layer of the nuclear membrane of all cells.

Deletion of ATM and Rad3 related protein leads to acute tissue loss.

In chronic viral infections or tumors, peptides that selectively inhibit PTPRS can be utilized to boost insufficient activity of pDCs.

Patients in stable partnerships have a slower progression from HIV to AIDS.

Mouse models can be generated using "artificial spermatids."


Pioneer factor OCT3/4 interacts with major chromatin remodeling factors.

Recognition of start codons depends on the translation initiation factor IF3.

Decrease of p62 in prostate tumor stroma results in defective autophagy.

Lmna knock-in models are appropriate for testing therapeutic approaches against Hutchinson-Gilford progeria syndrome (HGPS).

Glycan adaptation is rarely observed in the B-cell repertoire.

There is a positive correlation between hip fractures and statin use.

Physical activity level has no association with the difference in maximal oxygen consumption between black and white youth.

Increased microtubule acetylation repairs interference of axonal transport caused by LRRK2 Roc-COR domain mutations.

Including pharmacists in rounding teams does not alter the incidence of adverse drug events (ADEs).

BiP is a general endoplasmic reticulum stress marker.

There is no known interaction between Pioneer factor OCT3/4 and major chromatin remodeling factors.

The predominant localization of Linc00173 is in mononuclear macrophage nuclei.

Addition of BMP4, activin A, CHIR99021, and SU504 to reprogramming fibroblasts generates, expands and maintains cardiovascular progenitor cells (CPCs)

The PPR MDA5 has twenty N-terminal CARD domains.

Genes regulated by Esrrb transcription factor are sensitive to Mbd3 function.

Fibroblast growth factor 21 protects against atherosclerosis by modulating adiponectin and SREBP2 levels.

Long - range chromatin interactions regulate transcription.

CCL19 is predominantly present within dLNs.


Polymeal nutrition increases cardiovascular mortality.

Inhibiting glucose-6-phospate dehydrogenase improves lipogenesis by deactivating LKB1-AMPK signaling.

CD44v6 is not associated with constitutive and reprogrammed cancer stem cells driving cancer metastasis.

The origin of the CRF01_1b2k protein occurred between 1923 and 1956.

Healthy volunteers exhibit rapid and transient increase of cellular ATP after being bolus-injected with fructose.

Helicobacter pylori-induced aberrant NF-kB-dependent expression of activation-induced cytidine deaminase contributes to the mutagenesis of host DNA.

Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission.

Converting apoE4 to apoE3 by gene editing prevents the pathology associated with apoE4 in human iPSCderived neurons.

Long chain polyunsaturated fatty acids supplementation reduces wheezing and asthma.

Suboptimal nutrition is a leading cause of premature death

Moderate consumption of candy and chocolate reduces the risk of cardiovascular disease (CVD).

LDL cholesterol has a causal role in the development of cardiovascular disease.

It is not proven that moderate consumption of candy and chocolate reduces the risk of cardiovascular disease (CVD) specifically.

Long chain polyunsaturated fatty acids supplementation is associated with lower rates of atopic eczema at 1 year.

Weighed food records (WFR) result in poor completion since they're costly to run and impose high participant burden.

Consumption of whole fruits increases the risk of type 2 diabetes.

Weighed food records (WFR) result in high completion since they're cheap to run and impose low participant burden.


Post-transcriptional handling of mitochondrial transcripts occurs in mitochondrial RNA granules.

7-day-old adult Caenorhabditis elegans exhibit approximately 5% of the learning capacity seen in 1-day old adults.

Tuberculosis-induced granulomas express different immune system protein signatures than the surrounding tissue.

De novo assembly of sequence data has shorter contigs than unassembled sequence data.

Forkhead 0 (fox0) transcription factors are involved in cellular differentiation.

PKG-la does not have a large impact on expression of spinal long term potentiation in PGK-la knockout mice.

Allogeneic mechanical circulatory support is not as effective as autologous mechanical circulatory support for treating acute myocardial infarction.

Bacterial meningitis can be diagnosed on the basis of positive cerebrospinal fluid (CSF) cultures.

Androgenetic haploid mouse embryonic stem cells (ESCs) can be derived and genetically manipulated in vitro.

Transplanted human glial progenitor cells can mature in their host animal.

aPKCz causes tumour suppression by affecting glutamine metabolism.

Lamins are found within the inner layer of the mitochondrial membrane of all cells.

Genes involved in pre-mRNA splicing have a significant impact on genome stability.

Pre-mRNAs associated with spliceosomal components are less stable than unassociated splicing substrates.

Pre-mRNAs associated with spliceosomal components are more stable than unassociated splicing substrates.

miRNAs regulate a unique suite of mRNAs to maintain homeostasis in cells.

Cellular differentiation of embryonic stem cells is accompanied by changes in replication timing, transcription and nuclear localization.

Trans-acting factors, such as lncRNAs, influence mRNA translation.

miRNAs enforce homeostasis by suppressing low-level ''leaky'' transcription.

Immune complex triggered cell death leads to sequestration of oxidized mitochondrial DNA.


Pre-mRNAs associated with spliceosomal components are less stable than unassociated splicing substrates.

There is no increased risk of hypospadias with clomiphene.

Exposure to fine particulate air pollution is unrelated to anxiety prevalence.

Charcoal is an effective treatment for acute paraquat poisoning.

The innate immune response struggles to remove small numbers of parasites.

BiP is a general endoplasmic reticulum stress marker.

A 100g dose of chloroquine chemoprophylactic regimen results in retinal toxicity after 1 year of weekly intake.

Type 1 Diabetes is associated with subtle perturbations in T reg development.

Omnivores produce less trimethylamine N-oxide from dietary I-carnitine than vegans.

Pseudoknots are not evolutionarily conserved in most eukaryotes.

mcm 5 s 2 U is required for proper decoding of NNR codons in eukaryotes.

r-protein chaperones are found in complexes with their r-protein binding partners.

IFIT1 speeds viral replication by allowing for the proliferation of mis-capped viral RNAs.


Pre-mRNAs associated with spliceosomal components are more stable than unassociated splicing substrates.

MFGE8 regulates fat absorption by binding to av-Beta3 and av-Beta5 integrins.

Chenodeoxycholic acid treatment increases brown adipose tissue activity.

The repeat-variable diresidue (RVD) in the loop of Transcription-Activator Like (TAL) effectors specifies the nucleotides-amino acid contact at the target promoter element.

Cnn1 recruitment varies with cell cycle timing.

Sequence conservation in gene regulatory regions between species is a poor predictor of conserved functionality.

The TRaF1/C5 rs10818488 allele polymorphism regulates the neighboring C5 gene.

ScPif1p has reduced binding ability to G-rich ssDNA compared to non-G-rich ssDNA.

Women with a lower birth weight are more likely to develop breast cancer later in life.

HAND2 methylation is a key step in early endometrial carcinogenesis.

Having a main partner improves HIV outcomes.


Prescribed exercise training improves quality of life.

Headaches are correlated with cognitive impairment.

Bariatric surgery increases rates of colorectal cancer.

Klf4 is important for proper myeloid cell differentiation.

During non-homologous end joining, the ligation step is not as tolerant of disrepairs and other distortions when joining 5' of strand breaks as compared to 3' strand breaks.

The mean suicide rate in women is higher after miscarriage than live birth.

Algerian physicians constitue the largest component of sub-Saharan Africa-trained physicians in the United States.

B cells go though plasmablast differentiation and antibody production by continuous expression of EBI2.

EG7 tumors can be killed by systemic oxaliplatin primed CD8+ T cells from the tumor-draining lymph node cells.

Toll-like receptor (TLR) signaling is involved in the pathogenesis of human MDS.

Hematopoietic Stem Cell purification reaches purity rates above 90%.

Exercise increases cancer mortality rates among Chinese citizens.

Exercise reduces cancer mortality rates among Chinese citizens.

Measuring routine outcomes is more beneficial to clinical practice than assessing treatment adherence.

Assessing treatment adherence is more beneficial to clinical practice than measuring routine outcomes.

General exercise therapy is more effective than rotator cuff exercises in reducing pain and improving function of the shoulder.

General exercise therapy is more effective than scapular stabilizer exercises in reducing pain and improving function of the shoulder.

Insulin decreases risk of severe kidney failure.


PrimPol degrades short DNA replication intermediates on the leading strand during DNA replication.

Elevated cell-free mitochondrial DNA levels are associated with mortality.

The NF-κB essential modulator gene induces intestinal inflammation by promoting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death.

Less than 10% of patients exposed to radiation have activated markers of mesenchymal stem cells.

Major antigen-induced signals from the T cell receptor and secondary signals from costimulatory receptors are required for T cell activation.

Medications to treat obesity have unwanted side effects.

HNF4A mutations are associated with macrosomia in infancy.

Activation of the Rac1 homolog CED-10 kills viable cells in SRGP-1 mutant Caenorhabditis elegans.

Rotator cuff exercises are more effective than general exercise therapy in reducing pain and improving function of the shoulder.

Binding of p53 to enhancer regions (p53BERs) regulates the activity of p53 transcription and cell cycle arrest through the production of p53-dependent eRNAs.

NR5A2 is important in reverse cholesterol transport in humans.

PrimPol generates short DNA replication intermediates on the leading strand during DNA replication.

Mice defective for deoxyribonucleic acid (DNA) polymerase m (polm) fail to reveal increased sensitivity to ionizing radiation (IR).

Mice defective for deoxyribonucleic acid (DNA) polymerase I (polI) fail to reveal increased sensitivity to ionizing radiation (IR).

Mice defective for deoxyribonucleic acid (DNA) polymerase m (polm) reveal increased sensitivity to ionizing radiation (IR).

Clathrin stabilizes the spindle fiber apparatus during mitosis.

MafA phosphorylation decreases its ubiquitination.

R2D2 stops miRNA production by increasing the selectivity of Dcr2 for long dsRNA.

MafA phosphorylation enhances its ubiquitination.

MafA ubiquitination increases the recruitment of coavtivator P/CAF by MafA.


PrimPol generates short DNA replication intermediates on the leading strand during DNA replication.

Combination nicotine replacement therapies with varenicline or bupropion are more effective after 12 weeks of reatment compared to varenicline monotherapy.

Increased microtubule acetylation exacerbates LRRK2 Roc-COR domain mutation induced locomotor deficits.

Lice attenuated SIV vaccines induce a stronger antigen-specific T cell response in lymph node cells.

Transcription factor EB induces transcription of pro-inflammatory cytokines in macrophages infected with Staphylococcus aureus.

Transplanted human glial progenitor cells can mature in their host animal.

There is no association between HNF4A mutations and diabetes risks.

7-day-old adult Caenorhabditis elegans exhibit approximately 75% of the learning capacity seen in 1-day old adults.

BLM gene encodes RecQ-class DNA helicase.

Prescribed exercise training improves quality of life.

A 100g dose of chloroquine chemoprophylactic regimen results in retinal toxicity after 5-6 years of weekly intake.

Emodin forms hydrogen bonds with residues involved in PGAM1 substrate binding.

RAD52 is involved in break-induced DNA replication (BIR).


Primary cervical cancer screening with HPV detection has lower longitudinal sensitivity than conventional cytology to detect cervical intraepithelial neoplasia grade 2.

Microglia are an innate immune cell type of the peripheral nervous system.

A 100g dose of chloroquine chemoprophylactic regimen results in retinal toxicity after 1 year of weekly intake.

The NF-κB essential modulator gene induces intestinal inflammation by promoting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death.

Tirasemtiv has no effect on cardiac muscle.

Intake of folic acid (FA) and vitamin B6 (VB6) reduces levels of homocysteine.

Gastric infection with Helicobacter pylori decreases risk of gastric cancer in humans.

In the UK, drowning affects boys and girls equally.

Chemical injury represses transglutaminase 2 activity.

Students who perform poorly in the early years of medical school are at increased risk for professional misconduct later in their careers.

Broadly HIV-1 Neutralizing Antibodies (bnAb) 10EB have no affinity for phospholipids.

Primary cervical cytology screening with HPV detection has higher longitudinal sensitivity to detect severe cervical intraepithelial neoplasia than conventional cytology.

The risk of breast cancer among parous women decreases with placental weight of pregnancies.

In breast cancer, the loss of myoepithelial cells slows the transition of ductal carcinoma in situ to invasive carcinoma.

In breast cancer, the loss of myoepithelial cells promotes the transition of ductal carcinoma in situ to invasive carcinoma.

1-1% of colorectal cancer patients are diagnosed with regional or distant metastases.

61% of colorectal cancer patients are diagnosed with regional or distant metastases.

Women with a lower birth weight are more likely to develop breast cancer later in life.

BRCA 1 mutation carriers' risk of breast and ovarian cancer depends on where the mutation is located.

CD44v6 is not associated with constitutive and reprogrammed cancer stem cells driving cancer metastasis.


Primary cervical cytology screening with HPV detection has higher longitudinal sensitivity to detect severe cervical intraepithelial neoplasia than conventional cytology.

BCL-2 promotes the apoptotic effects of c-Myc.

In rhesus macaques, daily subcutaneous injections of emtricitabine are ineffective at protecting against rectally transmitted simian-human immunodeficiency virus.

The repeat-variable diresidue (RVD) in the loop of Transcription-Activator Like (TAL) effectors specifies the nucleotides-amino acid contact at the target promoter element.

Rhythmic expression of Cry1 translates directly into a circadian regulation of cAMP signaling in gluconeogenesis.

MafA phosphorylation decreases its ubiquitination.

Incidence of heart failure increased by 10% in women since 1979.

Repressing IL-18 has negative effects on atherosclerotic lesion composition and progression.

Tonic signaling from the scFv prevents constitutive stimulation.

HbA1c consistently overestimates glycemic control in black individuals with Sickle cell trait (SCT).

Normal granulomas form in the presence of TNF in Zebrafish.

Ultrasound guidance significantly reduces the number of traumatic procedures when attempting needle insertion.

CRP is positively correlated with postoperative mortality following Coronary Artery Bypass Graft (CABG) surgery.

Ultrasound guidance significantly reduces the number of needle insertion attempts necessary for a given procedure.

The combination of physical examinations with C-reactive protein values do not improve the accuracy of radiographic verified pneumonia predictions.

High levels of CRP lead to a higher risk of exacerbations in chronic obstructive pulmonary disease (COPD).


Primary pro-inflammatory cytokines suppress secondary pro- and anti-inflammatory mediators.

Ethanol stress increases the expression of IBP in bacteria.

ATM and Rad3 related protein have no role in sensing DNA damage.

90% of patients with melanoma and an objective response to PD-1 blockade will experience a progression in their melanoma.

Pharmacist attendance at ward rounds increases adverse events in wards.

There is no relation between Erythromycin use and hypertrophic pyloric stenosis.

Most termination events in Okazaki fragments are dictated by initiation patterns.

Bariatric surgery reduces colorectal cancer.

Increased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm.

7-day-old adult Caenorhabditis elegans exhibit approximately 5% of the learning capacity seen in 1-day old adults.

Pro-inflammatory cytokines are up regulated during tumor development.

Tumor development occurs in conjunction with upregulation of pro-inflammatory cytokines.

Many cytokines that are produced by cancer cells also contribute to carcinogenesis.

Pro-inflammatory cytokines are up repressed during tumor development.

Tumor development occurs in conjunction with suppression of pro-inflammatory cytokines.

Cholesterol loading induces KLF4 expression in VSMCs, resulting in the expression of pro-inflammatory cytokines.

The density of cytokine receptor bearing cells affects the distance over which cytokines act.

The density of cytokine receptor bearing cells has no effect on the distance over which cytokines act.

The minor G allele of FOXO3 downregulates pro-inflammatory cytokines.


Pro-inflammatory cytokines are up regulated during tumor development.

Intra-cerebroventricular infusion of amyloid-β oligomers increases expression of fibronectin type-III domain-containing protein 5 mRNA in mice hippocampi.

PKG-la does not have a large impact on expression of pain hypersensitivity in PGK-la knockout mice.

Aged patients are less susceptible to ischaemia/reperfusion injury.

Converting apoE4 to apoE3 by gene editing prevents the pathology associated with apoE4 in human iPSCderived neurons.

Chemical injury represses transglutaminase 2 activity.

ER-localized phosphatase Sac1 processes PI4P through coordination with OSBP and the endosome-localized protein sorting nexin 2.

Higher plasma levels of I-carnitine, when associated with trimethylamine N-oxide, are negatively correlated with cardiovascular events in humans.

Ethanol stress increases the expression of PSP in bacteria.

Systemic immunosuppressive (IS) therapy increases the chance of cancer mortality in patients with inflammatory eye disease (IED)

In British Men, haplogroup I increases risk of cardiovascular disease by 50%.

Cancer-associated fibroblasts (CAFs) interact with cancer cells to mediate formation and activation of CAFs.

Cancer-associated fibroblasts (CAFs) have no known interaction with cancer cells in the formation and activation of CAFs.

The cytokine receptor which regulates chemotaxis and formation of lymph nodes is involved in production of myeloperoxidase in the left atrium.

Cancer-associated fibroblasts (CAFs) are constituents of tumor microenvironments


Pro-inflammatory cytokines are up repressed during tumor development.

Vitamin D is an important factor in the relationship between calcium and parathyroid hormone.

Low nucleosome occupancy correlates with high methylation levels across species.

MafA ubiquitination decreases the recruitment of coavtivator P/CAF by MafA.

miRNAs regulate a unique suite of mRNAs to maintain homeostasis in cells.

The H2A-H2B eviction defect is compensated for by other histone chaperone(s).

Dexamethasone increases risk of postoperative bleeding.

Specialized functional cell types can be derived from human pluripotent stem cells.

The repeat-variable diresidue (RVD) in the loop of Transcription-Activator Like (TAL) effectors specifies the nucleotides-amino acid contact at the target promoter element.

Blocking the interaction between TDP-43 and respiratory complex I proteins ND3 and ND6 prevents TDP-43-induced neuronal loss.

Destination container port throughput(CPT) is positively related to dengue virus (DENV-1) diffusion in air traffic shipments.

Cancer cells can stimulate the accumulation of intra-tumoural myeloid-derived suppressor cells by promoting granulocyte colony stimulating factor production.


Progerin induces premature aging in stem cells.

AMP-activated protein kinase (AMPK) activation reduces inflammation-related fibrosis in the lungs.

LSD1-positive promoters are associated with RNA polymerase II

BLM gene encodes RecQ-class DNA helicase.

In transgenic mice harboring green florescent protein under the control of the Sox2 promoter, more than 50 percent of the cells with green florescent colocalize with cell proliferation markers.

Roughly 55% of women with chronic pelvic pain have no underlying pathology.

Pyridostatin stabilizes the G - quadruplex in the telomeric region.

Foxp3 enables the expression of transcriptional regulators implicated in memory T cell development.

Guanine nucleotide exchange factors (GEFs) mediate RhoA activation in response to tensional forces on fibronectin-binding integrins.

Differentiation of progenitor cells to myeloid cells is skewed upon activation of insulin signaling.

YAP/TAZ is required in intestinal regeneration in mouse models of ulcerative colitis.

Environmentally-induced senescence is mimicked in disease modeling by adding specific molecules to the culture system.

Up-regulation of the p53 pathway and related molecular events speeds cancer progression.

eRNAs influence is linked to senescence, aging, and carcinogenesis.

Autophagy deficiency in the liver increases vulnerability to insulin resistance.

Cellular differentiation of embryonic stem cells is accompanied by changes in replication timing, transcription and nuclear localization.

Physical injury represses transgultaminase activity.

Activated Cdk5 regulates DNA damage-induced neuronal death.

The proliferative capacity of progenitors is regulated cell-autonomously.


Propriospinal interneurons that play a role in the plastic reorganization of spinal circuits are integral for recovery from spinal cord injury.

Removal of H3K9me3 by ectopic expression of other H3K9 demethylases improves reprogramming efficiency in SCNT experiments.

aPKCz causes tumour suppression by affecting glutamine metabolism.

Activation of PPM1D enhances p53 function.

taa1 tar1 tar2 triple mutants in Arabidopsis do not make root meristem during embryogenesis.

Lack of FGF21 in mice leads to atherosclerotic plaque formation.

Bacterial meningitis can be diagnosed on the basis of positive cerebrospinal fluid (CSF) cultures.

76-85% of people with severe mental disorder receive no treatment in low and middle income countries.

Natriuretic peptides increase susceptibility to diabetes.

Surgical treatment is not superior to non-surgical in treating adults with displaced fractures of the proximal humerus.

Rotator cuff exercises are more effective than general exercise therapy in reducing pain and improving function of the shoulder.

The proliferative capacity of neural progenitors differs across species.

PKG-la plays an essential role in expression of spinal long term potentiation in PGK-la knockout mice.

The myocardial cell lineage originally develops from cardiac progenitors of exclusively endodermal origin.

Osteoparthritis (OA) is characterized by degeneration of articular cartilage, joint edge, and subchondral bone hyperplasia.

PKG-la does not have a large impact on expression of spinal long term potentiation in PGK-la knockout mice.

General exercise therapy is more effective than rotator cuff exercises in reducing pain and improving function of the shoulder.

Sudden death can occur in patients with complex ventricular arrhythmias.


Pseudogene PTENP1 encodes a transcript that regulates PTEN expression.

There was an estimated 30 million cases of pneumonia in young children worldwide in 2010.

M. stadtmanae induces ASC speck formation in BlaER1 monocytes.

Taxation of sugar-sweetened beverages reduced the incidence rate of type II diabetes in India.

Asymptomatic visual impairment screening in elderly populations leads to improved vision.

Men are more susceptible to death due to pneumonia when compared to women.

Monoclonal antibody targeting of N-cadherin encourages castration resistance.

Insulin decreases risk of severe kidney failure.

Hematopoietic Stem Cell purification reaches purity rates above 90%.

Nonsteroidal antinflammatory drugs show potential anticancer indications.

32% of liver transplantation programs required patients to discontinue methadone treatment in 2001.

PTEN is a regulator for the transcriptional activity of SRF

Foxp3 enables the expression of transcriptional regulators implicated in memory T cell development.

Foxp3 represses the expression of transcriptional regulators implicated in memory T cell development.

TNFAIP3 is a glioblastoma tumor suppressor.

TNFAIP3 is a glioblastoma tumor enhancer.

MEK inhibitors are effective treatments in RAS-driven mouse models of cancer.

TNFAIP3 is a tumor enhancer in glioblastoma.

Forkhead 0 (fox0) transcription factors are involved in apoptosis.

Up-regulation of the p53 pathway and related molecular events speeds cancer progression.