0-dimensional biomaterials lack inductive properties.

Rising temperatures caused by global warming increases risk of dengue fever transmission.

Osteoparthritis (OA) is characterized by degeneration of articular cartilage, joint edge, and subchondral bone hyperplasia.

MFGE8 regulates fat absorption by binding to av-Beta3 and av-Beta5 integrins.

Repressing IL-18 has negative effects on atherosclerotic lesion composition and progression.

Up-regulation of the p53 pathway and related molecular events speeds cancer progression.

ATF4 is a general endoplasmic reticulum stress marker.

Consumption of whole fruits increases the risk of type 2 diabetes.

Human embryonic stem cells give rise to cell types from the outer embryonic germ layer, but not the other two layers.

MT binding domain drives amyloid structure formation.

The NF-κB essential modulator gene prevents intestinal inflammation by inhibiting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death.

Flexible molecules experience less steric hindrance in the tumor microenviroment than rigid molecules.

Myelin sheaths are lipid-rich cellular structures.

Adult tissue-resident macrophages possess a self-renewing capacity.

Mitochondria play a major role in energy production.

Pure neural progenitor cell (NPC) populations can only be obtained from cell cultures that undergo passaging, filtration, or other isolation and cell sorting methods.

The proliferative capacity of neural progenitors differs across species.

Immune responses in immune cells are geographically segregated.

Specialized functional cell types can be derived from human pluripotent stem cells.

Bone marrow cells don't contribute to adult macrophage compartments.


1 in 5 million in UK have abnormal PrP positivity.

Chinese individuals with TT homozygosity in the MTHFR gene are less vulnerable to strokes caused by low levels of folate intake.

Cellular differentiation of embryonic stem cells is accompanied by changes in replication timing, transcription and nuclear localization.

Pseudoknots are not evolutionarily conserved in most eukaryotes.

Cancers that initially benefit from epidermal growth factor receptor targeted therapies later become refractory through several mechanisms.

Antimicrobial agents are less effective due to the pressure of antimicrobial usage.

Sequence conservation in gene regulatory regions between species is a high-accuracy predictor of conserved functionality.

In S. cerevisiae, the absence of RNA surveillance pathways reduces sensitivity to high iron conditions.

The DESMOND program demonstrates no significant impact on biochemical outcomes.

Approximately 250,000 people are infected with human T-cell lymphotropic virus type 1 in the United Kingdom.

High levels of CRP lead to a higher risk of exacerbations in chronic obstructive pulmonary disease (COPD).

Sepsis related mortality has risen from 2009 to 2014.

Incidence of sepsis has fallen substantially from 2009 to 2014.

Neutrophil extracellular trap (NET) antigens may contain the targeted autoantigens PR3 and MPO.

Decreased conversion of PGE 2 to PPARy ligand 15-ket-PGE 2 causes accumulation of PGE.

Tuberculosis incidence occurs at higher rates in more sparsely populated areas in the UK.

Increased conversion of PGE 2 to PPARy ligand 15-ket-PGE 2 causes accumulation of PGE.

Sepsis related mortality has remained stable between 2009-2014.


1-1% of colorectal cancer patients are diagnosed with regional or distant metastases.

Patients with microcytosis and higher erythrocyte count are more vulnerable to severe malarial anaemia when infected with Plasmodium falciparum.

Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 encourage West Nile virus replication in cortical neurons.

KRT17 modulates the expression of the transcriptional regulator AIRE in diseased epithelia.

Pioglitazone use is not associated with an increased risk of prostate cancer.

Deregulation of HAND2 is a crucial step in endometrial carcinogenesis in mice.

T cell receptor /CD3 microdomains are required to induce the immunologic synapse.

Thiopurine active metabolites can be catabolized through dephosphorylation of thioguanine nucleotides.

Ca2+ cycling controls whole-body energy homeostasis in beige fat.

MT binding domain drives amyloid structure formation.

Natriuretic peptides increase susceptibility to diabetes.

61% of colorectal cancer patients are diagnosed with regional or distant metastases.

Ten percent (10%) of kidney cancers in the UK are attributable to excess weight.

Bariatric surgery reduces colorectal cancer.

Bariatric surgery increases rates of colorectal cancer.

At least 85% of patients exposed to radiation have activated markers of myofibroblasts.

Metastatic colorectal cancer treated with a single agent fluoropyrimidines resulted in similar efficacy and better quality of life when compared with oxaliplatin-based chemotherapy in elderly patients.

Cancer-associated fibroblasts (CAFs) have no known interaction with cancer cells in the formation and activation of CAFs.

Less than 10% of patients exposed to radiation have activated markers of mesenchymal stem cells.

ALDH1 expression is associated with poorer prognosis for breast cancer primary tumors.


10% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.

Distant CREs are less conserved among species.

BCL-2 activation antagonizes the apoptotic effects of c-Myc.

Sympathetic nerve activity is elevated throughout normal pregnancy.

Therapeutics receiving accelerated approval encounter a lower frequency of post-marketing safety events

1 in 5 million in UK have abnormal PrP positivity.

Increased flux of microbial products suppresses immune responses.

Lack of FGF21 in mice increases life expectancy.

Bariatric surgery leads to negative outcomes in mental health.

Carriers of HNF4A mutations are at reduced risk for diabetes.

Vitamin D is an important factor in the relationship between calcium and parathyroid hormone.

90% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.

The mean suicide rate in women is lower after miscarriage than live birth.

The mean suicide rate in women is higher after miscarriage than live birth.

53% of perinatal mortality is due to low birth weight.

There was an estimated 30 million cases of pneumonia in young children worldwide in 2010.

The peak incidence of fractures occurs in toddlers.

Sepsis related mortality has risen from 2009 to 2014.

For every 1,000 children with cerebral palsy, more than 300 of them are premature or underweight at birth.

Incidence of sepsis has fallen substantially from 2009 to 2014.


32% of liver transplantation programs required patients to discontinue methadone treatment in 2001.

Activation of the Rac1 homolog CED-10 kills viable cells in SRGP-1 mutant Caenorhabditis elegans.

Ribosomal protein (RP) expression is controlled in part by stress-activated regulators.

Pre-mRNAs associated with spliceosomal components are more stable than unassociated splicing substrates.

TNFAIP3 is a tumor enhancer in glioblastoma.

KLF4 is necessary for VSMCs to gain genetic characteristics of other cell types within atherosclerotic lesions.

Increased microtubule acetylation exacerbates LRRK2 Roc-COR domain mutation induced locomotor deficits.

Crossover hot spots are found within gene promoters in Saccharomyces cerevisiae.

Foxk2 regulates autophagy genes in muscle cells and fibroblast cells.

Pyridostatin prevents double-strand breaks accumulation.

The US health care system can save up to $5 billion if 7% of patients waiting for kidney transplants participate in the optimized national kidney paired donation program.

CRP is positively correlated with postoperative mortality following Coronary Artery Bypass Graft (CABG) surgery.

A breast cancer patient's capacity to metabolize tamoxifen influences treatment outcome.

Pioglitazone use is significantly associated with an increased risk of pancreatic cancer.

Angiotensin converting enzyme inhibitors are associated with decreased risk for functional renal insufficiency.

The relationship between a breast cancer patient's capacity to metabolize tamoxifen and treatment outcome is independent of the patient's genetic make-up.

Risk of cardiovascular events can be cut by a third by using antihypertensive drug therapy among hemodialysis patients.

Incidence of heart failure increased by 10% in women since 1979.

61% of colorectal cancer patients are diagnosed with regional or distant metastases.


4-PBA treatment decreases endoplasmic reticulum stress in response to general endoplasmic reticulum stress markers.

Bacteriophagaes MS2 and Qβ are members of the Leviviridae.

Approximately 250,000 people are infected with human T-cell lymphotropic virus type 1 in the United Kingdom.

Mice are incapable of producing neutralizing antibodies in reponse to the Chikungunya virus (CHIKV) produced in mosquitos.

Ly6C hi monocytes have a higher inflammatory capacity than Ly6C lo monocytes.

Chemical injury represses transglutaminase 2 activity.

The density of cytokine receptor bearing cells affects the distance over which cytokines act.

The most prevalent adverse events to Semaglutide are gastrointestinal.

Misunderstandings between doctors and patients can lead to non-adherence.

APOE4 expression in iPSC-derived neurons results in decreased tau phosphorylation.

A single nucleotide variant the gene DGKK is strongly associated with increased risk of hypospadias.

4-PBA treatment raises endoplasmic reticulum stress in response to general endoplasmic reticulum stress markers.

CHOP is a general endoplasmic reticulum stress marker.

BiP is a general endoplasmic reticulum stress marker.

ATF4 is a general endoplasmic reticulum stress marker.

MafA ubiquitination increases the recruitment of coavtivator P/CAF by MafA.

MafA ubiquitination decreases the recruitment of coavtivator P/CAF by MafA.

Emodin forms hydrogen bonds with residues involved in PGAM1 substrate binding.

Glucose restriction to 0.05% reduces RLS (replicative life span) by 20-40% in S. cerevisiae.

Ethanol stress increases the expression of IBP in bacteria.


4-PBA treatment raises endoplasmic reticulum stress in response to general endoplasmic reticulum stress markers.

L3MBTL2 binds to H2AK119Ub marked chromatin to form a PRC1 complex.

Female carriers of the Apolipoprotein E4 (APOE4) allele have shorter lifetime exposure to estrogen due to a decreased reproductive period.

Lamins are found within the inner layer of the mitochondrial membrane of all cells.

The removal of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells.

IL-10 production by monocytes inhibits CD4 + T cell response.

Long chain polyunsaturated fatty acids supplementation has no significant effects on wheezing or asthma at 3 and 6 years.

F4/80+ macrophages regulate mature osteoblast maintenance.

B cells go though plasmablast differentiation and antibody production by continuous expression of EBI2.

Ethanol stress reduces the expression of SRL in bacteria.

Radioiodine treatment of non-toxic multinodular goitre increases thyroid volume.


40mg/day dosage of folic acid and 2mg/day dosage of vitamin B12 does not affect chronic kidney disease (CKD) progression.

Distant CREs are important for transcriptional regulation.

Insulin effects appetite via ventral tegmental neurons.

Depletion of nitric oxide is responsible for vasospasm.

ART has no effect on the infectiveness of HIV-positive people.

CRP is positively correlated with postoperative mortality following Coronary Artery Bypass Graft (CABG) surgery.

Risk-adjusted mortality rates are similar in teaching and non-teaching hospitals.

Bariatric surgery increases rates of colorectal cancer.

Patients in stable partnerships progress from HIV to death at the same rate as patients not in partnerships.

Deletion of ATM and Rad3 related protein is not predictive of acute tissue loss.

Exhaustion of B cells contributes to poor Ab response in HIV-infected individuals.

A deficiency of vitamin B12 decreases blood levels of homocysteine.

A deficiency of folate increases blood levels of homocysteine.

Insulin decreases risk of severe kidney failure.

Vitamin D deficiency effects birth weight.

Vitamin D is an important factor in the relationship between calcium and parathyroid hormone.

The US health care system can save up to $5 billion if 7% of patients waiting for kidney transplants participate in the optimized national kidney paired donation program.

A deficiency of vitamin B6 decreases blood levels of homocysteine.

Ten percent (10%) of kidney cancers in the UK are attributable to excess weight.


Patients with common epithelial cancers  are more likely to have an emergency event as their first hospital admission if they live in resource-deprived areas.

Increased flux of microbial products provokes immune responses.

Helminths interfere with immune system control of coinfections by microbial pathogens 16.

Homozygous deletion of murine Sbds gene from osterix-expressing mesenchymal stem and progenitor cells (MPCs) induces oxidative stress.

Replacement of OCT4 and SOX2 genes with GATA3 has the ability to reprogram human cells.

Rhythmic expression of Cry1 translates directly into a circadian regulation of cAMP signaling in hepatic glucose metabolism.

Chinese individuals with TT homozygosity in the MTHFR gene are more vulnerable to strokes caused by low levels of folate intake.

Cis-acting lncRNAs control the expression of genes that are positioned in the vicinity of their transcription sites.

The DESMOND program demonstrates no significant impact on biochemical outcomes.

Understanding epigenetic regulation of replication is essential for the reational design of episomally replicating vectors.

Guanine nucleotide dissociation inhibitor (Rho-GDI) interacts with the p75 NTR death domain

Ribosome-inactivating protein-2 (RIP-2) interacts with the p75 NTR death domain

Formation of N-terminal pyroglutamate by glutamine cyclase (GC) competes with NTAQ1 for Nt-Gln substrates.

The PPR MDA5 has twenty N-terminal CARD domains.

C2 works synergistically with A-769662 to activate dephosphorylated AMPK.

p75 NTR - associated cell death executor (NADE) interacts with the p75 NTR death domain

B3-Galectin decreases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR.

B3-Galectin increases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR.

Removal of H3K9me3 by ectopic expression of other H3K9 demethylases improves reprogramming efficiency in SCNT experiments.


50% of patients exposed to radiation have activated markers of mesenchymal stem cells.

The minor G allele of FOXO3 up-regulates IL-10.

PD-1 triggering on monocytes enhances IL-10 production by monocytes.

In British Men, haplogroup I decreases risk of cardiovascular disease.

Lysine histone demethylase inhibitor JIB 04 is inactive against KDM5A.

Removal of H3K9me3 by ectopic expression of other H3K9 demethylases improves reprogramming efficiency in SCNT experiments.

Rising temperatures caused by global warming lowers the risk of dengue fever transmission.

C2 works synergistically with A-769662 to activate dephosphorylated AMPK.

Algerian physicians constitue the largest component of sub-Saharan Africa-trained physicians in the United States.

Genetic deletion of JAM-A increases gut permeability.

Citrullinated proteins externalized in neutrophil extracellular traps act indirectly to disrupt the inflammatory cycle.

Less than 10% of patients exposed to radiation have activated markers of mesenchymal stem cells.

At least 85% of patients exposed to radiation have activated markers of myofibroblasts.

1-1% of colorectal cancer patients are diagnosed with regional or distant metastases.

61% of colorectal cancer patients are diagnosed with regional or distant metastases.

Cancer-associated fibroblasts (CAFs) have no known interaction with cancer cells in the formation and activation of CAFs.

Many cytokines that are produced by cancer cells also contribute to carcinogenesis.

Cancer-associated fibroblasts (CAFs) interact with cancer cells to mediate formation and activation of CAFs.

In pediatric tissue, most T cells are naive T cell emigrants from the thymus.


53% of perinatal mortality is due to low birth weight.

Nuclear transfer from adult human fibroblasts to human oocytes can give rise to blastocysts containing expandable pluripotent cells.

Stiff substrates encourage mesodermal differentiation by degrading beta-catenin in an integrin-dependent manner.

90% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.

Cellular clocks are not predictive of mitosis timing in NIH 3T3 cells.

Physical injury represses transgultaminase activity.

Increased mobility of retrotransposons does not lead to mutation and higher tumorigenesis rates.

Ultrasound guidance significantly reduces the number of traumatic procedures when attempting needle insertion.

MUC1-C activates the NF-κB p65 signaling pathway by interacting with IκB kinase ß.

Formation of N-terminal pyroglutamate by glutamine cyclase (GC) competes with NTAQ1 for Nt-Gln substrates.

The minor G allele of FOXO3 is related to less severe symptoms of Crohn's Disease.

The mean suicide rate in women is lower after miscarriage than live birth.

The mean suicide rate in women is higher after miscarriage than live birth.

Birth-weight is negatively associated with breast cancer.

10% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.

Women with a lower birth weight are more likely to develop breast cancer later in life.

For every 1,000 children with cerebral palsy, more than 300 of them are premature or underweight at birth.

The risk of breast cancer among parous women decreases with placental weight of pregnancies.

Excess gestational weight gain is associated with obesity-related pregnancy outcomes.


61% of colorectal cancer patients are diagnosed with regional or distant metastases.

Adult tissue-resident macrophages are seeded before birth.

Dscam1 acts as a hypervariable pattern-recognition receptor for the immune system.

Walking in traffic areas in London did not improve lung function in elderly adults.

Folate and vitamin B12 levels influence the association between homocysteine and preeclampsia.

Surfactin producing cells and exopolymer producing cells cooperate to generate "Van Gogh" bundles that have sliding abilities on specialized media.

Pyridostatin induces double-strand breaks accumulation.

The composition of myosin-II isoform switches from the A isoform to the B isoform during hematopoietic differentiation.

GATA3 regulates self-renewal capacity in bone marrow hematopoietic stem cells.

Scapular stabilizer exercises are more effective than general exercise therapy in reducing pain and improving function of the shoulder.

Primary cervical cytology screening with HPV detection has higher longitudinal sensitivity to detect severe cervical intraepithelial neoplasia than conventional cytology.

Ten percent (10%) of kidney cancers in the UK are attributable to excess weight.

Bariatric surgery reduces colorectal cancer.

Bariatric surgery increases rates of colorectal cancer.

Metastatic colorectal cancer treated with a single agent fluoropyrimidines resulted in similar efficacy and better quality of life when compared with oxaliplatin-based chemotherapy in elderly patients.

Cancer-associated fibroblasts (CAFs) have no known interaction with cancer cells in the formation and activation of CAFs.

At least 85% of patients exposed to radiation have activated markers of myofibroblasts.

Cancer-associated fibroblasts (CAFs) interact with cancer cells to mediate formation and activation of CAFs.

ALDH1 expression is associated with poorer prognosis for breast cancer primary tumors.


7-day-old adult Caenorhabditis elegans exhibit approximately 5% of the learning capacity seen in 1-day old adults.

B cells go though plasmablast differentiation and antibody production by continuous expression of EBI2.

Converting apoE4 to apoE3 by gene editing prevents the pathology associated with apoE4 in human iPSCderived neurons.

The World Health Organization's (WHO) data collection process is biased downward by unequal selection of larger outbreaks.

COPI coatmer is involved in viral replication.

cSMAC formation represses weak ligand signalling.

HSCT-T dosage may not be diagnostic if the onset of symptoms occurs less than 3 hours before AMI.

PTEN is a regulator for the transcriptional activity of SRF

Cytosolic proteins bind to iron-responsive elements on mRNAs coding for TFRC1.

Long - range chromatin interactions regulate transcription.

7-day-old adult Caenorhabditis elegans exhibit approximately 75% of the learning capacity seen in 1-day old adults.

Individuals with Alzheimers who participate in six months of physical activity improve cognitive function for up to 18 months.

Asymptomatic visual impairment screening in elderly populations leads to improved vision.

The peak incidence of fractures occurs during pubertal growth spurt in early adolescents.

Adult tissue-resident macrophages possess a self-renewing capacity.

The proliferative capacity of neural progenitors differs across species.

Hypothalamic glutamate neurotransmission is unrelated to energy balance.

Female carriers of the Apolipoprotein E4 (APOE4) allele have increased risk for Alzheimer's disease.


7-day-old adult Caenorhabditis elegans exhibit approximately 75% of the learning capacity seen in 1-day old adults.

Pioglitazone use is not associated with an increased risk of prostate cancer.

Autophagy deficiency in the liver increases vulnerability to insulin resistance.

F4/80+ macrophages regulate mature osteoblast maintenance.

Post-transcriptional handling of mitochondrial transcripts occurs in mitochondrial RNA granules.

Gpr124 suppresses BBB breakdown in mouse models of ischemic stroke.

Trans-acting factors, such as lncRNAs, influence mRNA translation.

Individuals with low serum vitamin D concentrations have decreased risk of multiple sclerosis.

Glycan adaptation is rarely observed in the B-cell repertoire.

The generation of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells.

C2 works synergistically with A-769662 to activate dephosphorylated AMPK.

For every 1,000 children with cerebral palsy, more than 300 of them are premature or underweight at birth.

Headaches are correlated with cognitive impairment.


70% of burn patients are admitted for hospitalization and further treatment after appearing at hospital emergency wards or outpatient clinics.

Pseudoknots are not evolutionarily conserved in most eukaryotes.

Rotator cuff exercises are more effective than general exercise therapy in reducing pain and improving function of the shoulder.

Angiotensin converting enzyme inhibitors are associated with decreased risk for functional renal insufficiency.

90% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.

The deregulated and prolonged activation of monocytes improves inflammatory disease outcomes.

53% of perinatal mortality is due to low birth weight.

In patients with congenital heart defects, β-blockers significantly improve clinical heart failure outcomes.

Rapamycin increases the concentration of triacylglycerols in fruit flies.

TRAP+ osteoclasts regulate mature osteoblast maintenance.

Patients with common epithelial cancers are less likely to have an emergency event as their first hospital admission if they live in resource-deprived areas.

Patients with common epithelial cancers  are more likely to have an emergency event as their first hospital admission if they live in resource-deprived areas.

Incidence of sepsis has fallen substantially from 2009 to 2014.

Sepsis related mortality has risen from 2009 to 2014.

One in five surgical randomized controlled trials are discontinued early.

Tuberculosis incidence occurs at higher rates in more sparsely populated areas in the UK.

One in two surgical randomized controlled trials are discontinued early.

High levels of CRP lead to a higher risk of exacerbations in chronic obstructive pulmonary disease (COPD).

Risk-adjusted mortality rates are similar in teaching and non-teaching hospitals.


76-85% of people with severe mental disorder receive no treatment in low and middle income countries.

The NF-κB essential modulator gene induces intestinal inflammation by promoting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death.

Hypocretin neurones suppress panicprone state in rats.

V-9302 inhibits antitumor responses by decreasing cell death and oxidative stress.

Autologous transplantation of mesenchymal stem cells has better graft function than induction therapy with anti-interleukin-2 receptor antibodies.

Cnn1 recruitment varies with cell cycle timing.

Cardiac tissue-resident macrophages directly contribute to electrical activity.

In melanoma, anti-CTLA-4 treatment reinvigorates exhausted PD-1+Eomes+CD8 T cells.

Stiff substrates inhibit mesodermal differentiation by degrading beta-catenin in an integrin-dependent manner.

N348I mutations cause resistance to nevirapine.

Eliminating the last sporadic cases of malaria requires considerable funding.

The proportion of people with visual difficulty is two times higher in low-income countries than in high-income countries.

The mean suicide rate in women is higher after miscarriage than live birth.

The mean suicide rate in women is lower after miscarriage than live birth.

90% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.

10% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.

53% of perinatal mortality is due to low birth weight.

Epidemiological disease burden from noncommunicable diseases is more prevalent in high economic settings.

Input from  mental and physical health care professionals is not effective at decreasing homelessness.


90% of patients with melanoma and an objective response to PD-1 blockade will experience a progression in their melanoma.

Cognitive behavioral therapy is an ineffective treatment for insomnia

Sequence conservation in gene regulatory regions between species is a high-accuracy predictor of conserved functionality.

Urbanization is an important risk factor related to the transmission of dengue fever.

Pre-mRNAs associated with spliceosomal components are more stable than unassociated splicing substrates.

Tirasemtiv has no effect on cardiac muscle.

Treatment with a protein named FN impairs regenerative abilities of aged muscles.

Dexamethasone increases risk of postoperative bleeding.

Formation of N-terminal pyroglutamate by glutamine cyclase (GC) competes with NTAQ1 for Nt-Gln substrates.

RANK-RANKL pathway signalling has no known association with development of Aire-expressing medullary thymic epithelial cells.

Vitamin D is an important factor in the relationship between calcium and parathyroid hormone.

In melanoma, anti-CTLA-4 treatment reinvigorates exhausted PD-1+Eomes+CD8 T cells.

Side effects associated with antidepressants increases risk of stroke.

The most prevalent adverse events to Semaglutide are cardiovascular.

In patients with congenital heart defects, β-blockers significantly improve clinical heart failure outcomes.

A breast cancer patient's capacity to metabolize tamoxifen influences treatment outcome.

Incidence of 10/66 dementia is lower than the incidence of DSM-IV dementia.

Incidence of 10/66 dementia is higher than the incidence of DSM-IV dementia.

The relationship between a breast cancer patient's capacity to metabolize tamoxifen and treatment outcome is independent of the patient's genetic make-up.

PD-1 triggering on monocytes enhances IL-10 production by monocytes.


90% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.

Cost effectiveness evaluations based on cRCT data accurately reflect prices for patients in actual clinical practice.

CD44v6 is not associated with constitutive and reprogrammed cancer stem cells driving cancer metastasis.

The deamination of cytidine to uridine on the minus strand of viral DNA can inactivate the viral genome by inducing G-to-A mutations.

CDK6 shows impaired binding to loss-of-function variants of p18 INK4C.

Distant CREs are important for transcriptional regulation.

Chinese individuals with TT homozygosity in the MTHFR gene are less vulnerable to strokes caused by low levels of folate intake.

Long chain polyunsaturated fatty acids supplementation is associated with lower rates of atopic eczema at 1 year.

Expression of oncolytic virus antigens as peptides makes relapse more likely.

Cancer-associated fibroblasts (CAFs) have no known interaction with cancer cells in the formation and activation of CAFs.

Asymptomatic visual impairment screening in elderly populations leads to improved vision.

The mean suicide rate in women is higher after miscarriage than live birth.

There was an estimated 30 million cases of pneumonia in young children worldwide in 2010.

The peak incidence of fractures occurs in toddlers.

Sepsis related mortality has risen from 2009 to 2014.

For every 1,000 children with cerebral palsy, more than 300 of them are premature or underweight at birth.

Incidence of sepsis has fallen substantially from 2009 to 2014.


A 100g dose of chloroquine chemoprophylactic regimen results in retinal toxicity after 1 year of weekly intake.

Smc5/6 engagment halts the activation of SUMO E3 ligase Mms21 by ATP-dependent remolding.

Chenodeoxycholic acid treatment decreases brown adipose tissue activity.

Post-transcriptional handling of mitochondrial transcripts occurs in mitochondrial RNA granules.

The deregulated and prolonged activation of monocytes has deleterious effects in chronic infectious conditions.

Exercise reduces cancer mortality rates among Chinese citizens.

Induced hepatic stem cells possess the potential to differentiate into hepatocytic cells.

Increased conversion of PGE 2 to PPARy ligand 15-ket-PGE 2 causes accumulation of PGE.

4-PBA treatment raises endoplasmic reticulum stress in response to general endoplasmic reticulum stress markers.

Reduced responsiveness to interleukin-2 in regulatory T cells is associated with autoimmune diseases such as Type 1 Diabetes.

A 100g dose of chloroquine chemoprophylactic regimen results in retinal toxicity after 5-6 years of weekly intake.

Varenicline monotherapy is more effective after 26 weeks of treatment compared to combination nicotine replacement therapies with varenicline or bupropion.

The most prevalent adverse events to Semaglutide are gastrointestinal.

Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission.

The most prevalent adverse events to Semaglutide are cardiovascular.

Combination nicotine replacement therapies with varenicline or bupropion are more effective after 12 weeks of reatment compared to varenicline monotherapy.

There is no increased risk of hypospadias with clomiphene.

Sildenafil worsens erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.

Metastatic colorectal cancer treated with a single agent fluoropyrimidines resulted in similar efficacy and better quality of life when compared with oxaliplatin-based chemotherapy in elderly patients.


A 100g dose of chloroquine chemoprophylactic regimen results in retinal toxicity after 5-6 years of weekly intake.

YAP/TAZ is required in intestinal regeneration in mouse models of ulcerative colitis.

Adult tissue-resident macrophages possess a self-renewing capacity.

The US health care system can save up to $5 billion if 7% of patients waiting for kidney transplants participate in the optimized national kidney paired donation program.

Cognitive behavioral therapy is an ineffective treatment for insomnia

Headaches are correlated with cognitive impairment.

The peak incidence of fractures occurs in toddlers.

In British Men, haplogroup I increases risk of cardiovascular disease by 50%.

The generation of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells.

Diminished ovarian reserve is a reliable indicator of infertility in a non-infertile population.

Antiretroviral therapy increases rates of tuberculosis across a broad range of CD4 strata.


A T helper 2 cell (Th2) environment impedes disease development in patients with systemic lupus erythematosus (SLE).

Including pharmacists in rounding teams reduces the incidence of adverse drug events (ADEs).

Ethanol stress lowers the expression of PSP in bacteria.

Gpr124 suppresses BBB breakdown in mouse models of ischemic stroke.

BLM gene encodes RecQ-class DNA helicase.

Active Ly49Q prevents neutrophil polarization.

miRNAs regulate a unique suite of mRNAs to maintain homeostasis in cells.

Environmental factors can influence the development of breast cancer.

DUSP4 downregulation deactivates the Ras-ERK pathway

Cancers that initially benefit from epidermal growth factor receptor targeted therapies later become refractory through several mechanisms.

Basophils promote disease development in patients with systemic lupus erythematosus (SLE).

Type 1 Diabetes is associated with subtle perturbations in T reg development.

Reduced responsiveness to interleukin-2 in regulatory T cells is associated with autoimmune diseases such as Type 1 Diabetes.

Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection decreases dissemination of Salmonella Typhimurium from the gut.

Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection increases dissemination of Salmonella Typhimurium from the gut.

Approximately 250,000 people are infected with human T-cell lymphotropic virus type 1 in the United Kingdom.

Lice attenuated SIV vaccines induce a stronger antigen-specific T cell response in lymph node cells.

EG7 tumors can be killed by systemic oxaliplatin primed CD8+ T cells from the tumor-draining lymph node cells.

In pediatric tissue, most T cells are naive T cell emigrants from the thymus.


A breast cancer patient's capacity to metabolize tamoxifen influences treatment outcome.

A deficiency of vitamin B6 decreases blood levels of homocysteine.

Inside the body, falciparum parasites reproduce asexually.

Chlamydia trachomatis is most prevalent in the UK among individuals in their 50s and 60s.

Treatment with the EC uptake inhibitor AM404 resulted in a dose-dependent decrease in the expression of immobility.

Individuals with low serum vitamin D concentrations have decreased risk of multiple sclerosis.

Transcription rates in S. cerevisiae range between 7 and 12 kb/min.

TNFAIP3 is a tumor enhancer in glioblastoma.

eRNAs influence is linked to senescence, aging, and carcinogenesis.

Reduced phosphorylation of PP2A suppresses HDAC4 dephosphorylation.

Cellular clocks are not predictive of mitosis timing in NIH 3T3 cells.

The relationship between a breast cancer patient's capacity to metabolize tamoxifen and treatment outcome is independent of the patient's genetic make-up.

Side effects associated with antidepressants do not represent a mortality risk to postmenopausal women.

Pioglitazone use is significantly associated with an increased risk of pancreatic cancer.

Pioglitazone use is significantly associated with an increased risk of prostate cancer.

Pioglitazone use is not associated with an increased risk of prostate cancer.

Side effects associated with antidepressants increases risk of stroke.

The most prevalent adverse events to Semaglutide are cardiovascular.

Side effects associated with antidepressants lower risk of myocardial infarction.


A country's Vaccine Alliance (GAVI) eligibility is not indictivate of accelerated adoption of the Hub vaccine.

There is no known interaction between Pioneer factor OCT3/4 and major chromatin remodeling factors.

Approximately 250,000 people are infected with human T-cell lymphotropic virus type 1 in the United Kingdom.

Pre-mRNAs associated with spliceosomal components are more stable than unassociated splicing substrates.

Incidence of sepsis has fallen substantially from 2009 to 2014.

Rapamycin increases the concentration of triacylglycerols in fruit flies.

There is no relation between Erythromycin use and hypertrophic pyloric stenosis.

IL-10 production by monocytes inhibits CD4 + T cell response.

BRCA 1 mutation carriers' risk of breast and ovarian cancer depends on where the mutation is located.

Adult tissue-resident macrophages are seeded before birth.

Patients in stable partnerships progress from HIV to death at the same rate as patients not in partnerships.

The World Health Organization's (WHO) data collection process is biased downward by unequal selection of larger outbreaks.

Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission.

Eilat virus (EILV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in nonhuman primates.

Nonhuman primates are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.

Therapeutics receiving accelerated approval encounter a lower frequency of post-marketing safety events

Rising temperatures caused by global warming lowers the risk of dengue fever transmission.

Exhaustion of B cells contributes to poor Ab response in HIV-infected individuals.

Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 encourage West Nile virus replication in cortical neurons.


A deficiency of folate increases blood levels of homocysteine.

Piezo1 channels are sensors for cell migration in epithelial cells.

Folate and vitamin B12 levels influence the association between homocysteine and preeclampsia.

Fibroblast growth factor 21 protects against atherosclerosis by modulating adiponectin and SREBP2 levels.

The NF-κB essential modulator gene prevents intestinal inflammation by inhibiting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death.

β-sheet opening occurs during pleurotolysin pore formation.

BCL-2 activation antagonizes the apoptotic effects of c-Myc.

Tonic signaling from the scFv induces constitutive stimulation.

Chlamydia trachomatis is most prevalent in the UK among individuals in their 50s and 60s.

ART has no effect on the infectiveness of HIV-positive people.

A deficiency of vitamin B12 decreases blood levels of homocysteine.

A deficiency of vitamin B6 decreases blood levels of homocysteine.

Intake of folic acid (FA) and vitamin B6 (VB6) reduces levels of homocysteine.

Intake of folic acid (FA) and vitamin B6 (VB6) increases levels of homocysteine.

Vitamin D is an important factor in the relationship between calcium and parathyroid hormone.

Autophagy deficiency in the liver increases vulnerability to insulin resistance.

LDL cholesterol has a causal role in the development of cardiovascular disease.

40mg/day dosage of folic acid and 2mg/day dosage of vitamin B12 does not affect chronic kidney disease (CKD) progression.


A deficiency of vitamin B12 decreases blood levels of homocysteine.

The G34R/V mutation creates a hypomethylated phenotype at the H3K36 histone.

miR-142-5P is a known regulator of raised body temperature.

Homozygous deletion of murine Sbds gene from osterix-expressing mesenchymal stem and progenitor cells (MPCs) induces oxidative stress.

The predominant localization of Linc00173 is in mononuclear macrophage nuclei.

Pre-mRNAs associated with spliceosomal components are more stable than unassociated splicing substrates.

Surgical treatment is not superior to non-surgical in treating adults with displaced fractures of the proximal humerus.

90% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.

Antidepressants reduce the severity of migraines.

TNFAIP3 is a tumor enhancer in glioblastoma.

Antimicrobial agents are more effective due to the pressure of antimicrobial usage.

Vitamin D deficiency effects birth weight.

Carriers of HNF4A mutations are at reduced risk for diabetes.


A deficiency of vitamin B6 decreases blood levels of homocysteine.

Increased flux of microbial products provokes immune responses.

Deletion of ATM and Rad3 related protein leads to acute tissue loss.

Patients with microcytosis and higher erythrocyte count were more resistant to severe malarial anaemia when infected with Plasmodium falciparum.

KLF4 is necessary for VSMCs to gain genetic characteristics of other cell types within atherosclerotic lesions.

Kir7.1 modulates channel activity by the G protein-coupled melanocortin-4 receptor (MC4R) in the paraventricular nucleus of the hypothalamus.

Omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegetarians.

Incidence of 10/66 dementia is lower than the incidence of DSM-IV dementia.

Increased vessel density along with a reduction in fibrosis improves the efficacy of chemotherapy treatments.

Progerin induces premature aging in stem cells.

The composition of myosin-II isoform switches from the A isoform to the B isoform during hematopoietic differentiation.


A diminished ovarian reserve does not solely indicate infertility in an a priori non-infertile population.

V-9302 inhibits antitumor responses by decreasing cell death and oxidative stress.

Taxation of sugar-sweetened beverages reduced the incidence rate of type II diabetes in India.

Vitamin D is an important factor in the relationship between calcium and parathyroid hormone.

Increased microtubule acetylation repairs interference of axonal transport caused by LRRK2 Roc-COR domain mutations.

Lack of FGF21 in mice increases life expectancy.

Autophagy deficiency in the liver increases vulnerability to insulin resistance.

7-day-old adult Caenorhabditis elegans exhibit approximately 75% of the learning capacity seen in 1-day old adults.

Beta-band coherence is enhanced for visible stimuli over invisible stimuli.

Monoclonal antibody targeting of N-cadherin encourages castration resistance.

Natriuretic peptides protect against diabetes.

A diminished ovarian reserve is a very strong indicator of infertility, even in an a priori non-infertile population.

Diminished ovarian reserve is a reliable indicator of infertility in a non-infertile population.

The mean suicide rate in women is lower after miscarriage than live birth.

The mean suicide rate in women is higher after miscarriage than live birth.

Female carriers of the Apolipoprotein E4 (APOE4) allele have shorter lifetime exposure to estrogen due to a decreased reproductive period.

Female carriers of the Apolipoprotein E4 (APOE4) allele have longer lifetime exposure to estrogen due to an increased reproductive period.

The risk of breast cancer among parous women decreases with placental weight of pregnancies.

The number of unfertilized oocytes in mated hermaphrodites increases with age.

Women with a lower birth weight are more likely to develop breast cancer later in life.


A diminished ovarian reserve is a very strong indicator of infertility, even in an a priori non-infertile population.

Students who perform poorly in the early years of medical school are at increased risk for professional misconduct later in their careers.

The mean suicide rate in women is higher after miscarriage than live birth.

Increased microtubule acetylation exacerbates LRRK2 Roc-COR domain mutation induced locomotor deficits.

Surfactin producing cells and exopolymer producing cells cooperate to generate "Van Gogh" bundles that have sliding abilities on specialized media.

Side effects associated with antidepressants do not represent a mortality risk to postmenopausal women.

Mice defective for deoxyribonucleic acid (DNA) polymerase I (polI) fail to reveal increased sensitivity to ionizing radiation (IR).

Perigenital skin is not the primary site of HIV acquisition.

Upregulation of PD1 causes the upregulation of Satb1.

The density of cytokine receptor bearing cells affects the distance over which cytokines act.

Aggravated inflammation is dependent on NLRP3 inflammasome activation.


A high microerythrocyte count protects against severe anemia in homozygous alpha (+)- thalassemia trait subjects.

50% of patients exposed to radiation have activated markers of mesenchymal stem cells.

Adult tissue-resident macrophages are seeded before birth.

Treatment with a protein named FN impairs regenerative abilities of aged muscles.

Diabetic patients with acute coronary syndrome experience decreased short-term and long-term risk for bleeding events.

Many cytokines that are produced by cancer cells also contribute to carcinogenesis.

Two variants of chromosome 6q21 are associated with radiation therapy-induced second malignancies in pediatric Hodgkin lymphoma patients.

Bariatric surgery leads to positive outcomes in mental health.

Increased mobility of retrotransposons does not lead to mutation and higher tumorigenesis rates.

A deficiency of vitamin B6 decreases blood levels of homocysteine.

A deficiency of vitamin B12 decreases blood levels of homocysteine.

HbA1c consistently overestimates glycemic control in black individuals with Sickle cell trait (SCT).

Mice without IFN-γ or its receptor are highly susceptible to EAM induced with α-MyHC/CFA.

A deficiency of folate increases blood levels of homocysteine.

The removal of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells.

The generation of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells.

Carriers of HNF4A mutations are at reduced risk for diabetes.

HNF4A mutations are associated with macrosomia in infancy.


A low percentage of hematopoietic progenitor cells are susceptible to HIV-1 infection ex vivo.

Pyridostatin decreases telomere fragility in BRCA2-deficient cells.

Incidence of 10/66 dementia is higher than the incidence of DSM-IV dementia.

Reduced phosphorylation of PP2A suppresses HDAC4 dephosphorylation.

Higher plasma levels of I-carnitine, when associated with trimethylamine N-oxide, are negatively correlated with cardiovascular events in humans.

A high microerythrocyte count protects against severe anemia in homozygous alpha (+)- thalassemia trait subjects.

In rhesus macaques, daily subcutaneous injections of emtricitabine are ineffective at protecting against rectally transmitted simian-human immunodeficiency virus.

cSMAC formation represses weak ligand signalling.

Post-transcriptional handling of mitochondrial transcripts occurs in mitochondrial RNA granules.

ART has no effect on the infectiveness of HIV-positive people.

Origin gross domestic product(GDP) is negatively related to dengue virus (DENV-1) diffusion in air traffic shipments.

The HSV-2 infection is typically asymptomatic.

Perigenital skin is not the primary site of HIV acquisition.

Chronic HIV stimulation of B cells leads to the premature exhaustion of B cells.

The latent infection of myeloid cells with human cytomegalovirus induces a number of changes in gene expression.

Exhaustion of B cells contributes to poor Ab response in HIV-infected individuals.

Approximately 250,000 people are infected with human T-cell lymphotropic virus type 1 in the United Kingdom.

Hematopoietic Stem Cell purification reaches purity rates above 90%.

Nonhuman primates are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.


A mutation in HNF4A leads to an increased risk of developing diabetes by the age of 14 years.

Ectopic expression of Sall4, Nanog, Esrrb, and Lin28 generates induced pluripotent stem cells from mouse embryonic fibroblasts more efficiently than other factor combinations.

Type 1 Diabetes is associated with subtle perturbations in T reg development.

Lack of FGF21 in mice leads to atherosclerotic plaque formation.

Gpr124 suppresses BBB breakdown in mouse models of ischemic stroke.

Ca2+ cycling is a UCP1-dependent thermogenic mechanism.

In pediatric tissue, most T cells are naive T cell emigrants from the thymus.

Ten percent (10%) of kidney cancers in the UK are attributable to excess weight.

Transcription rates in S. cerevisiae range between 0.7 and 2 kb/min.

The origin of the CRF01_1b2k protein occurred between 1923 and 1956.

A mutation in HNF4A leads to an increased risk of diabetes by the age of 14 years.

There is no association between HNF4A mutations and diabetes risks.

Female carriers of the Apolipoprotein E4 (APOE4) allele have increased risk for Alzheimer's disease.

Autophagy deficiency in the liver increases vulnerability to insulin resistance.

Female carriers of the Apolipoprotein E4 (APOE4) allele have decreased risk for dementia.

A deficiency of vitamin B12 decreases blood levels of homocysteine.

Female carriers of the Apolipoprotein E4 (APOE4) allele have shorter lifetime exposure to estrogen due to a decreased reproductive period.


A mutation in HNF4A leads to an increased risk of diabetes by the age of 14 years.

Localization of PIN1 in the roots of Arabidopsis requires VPS9a

CD28 signals regulate trafficking of murine auto-reactive T cells into target tissues.

A deficiency of vitamin B12 decreases blood levels of homocysteine.

Active H. pylori urease has a polymeric structure consisting of five distinct subunits.

Alteration of origin firing causes changes in termination zones of Okazaki fragments.

Gastric lavage is an effective treatment for acute paraquat poisoning.

Ca2+ cycling controls whole-body energy homeostasis in beige fat.

Human embryonic stem cells give rise to cell types from all three embryonic germ layers.

Origin gross domestic product(GDP) is positively related to dengue virus (DENV-1) diffusion in air traffic shipments.

Tonic signaling from the scFv induces constitutive stimulation.

Carriers of HNF4A mutations are at reduced risk for diabetes.

HNF4A mutations are associated with macrosomia in infancy.


A single nucleotide variant the gene DGKK is strongly associated with increased risk of hypospadias.

The risk of cancer rises with level of alcohol consumption.

Continued HHV-8 transmission among MSM in San Francisco may be explained by urogenital contact.

Long chain polyunsaturated fatty acids supplementation reduces wheezing and asthma.

APOE4 expression in iPSC-derived neurons results in decreased tau phosphorylation.

The artifactual C-terminal helix swapping in the StART domain is observed in the Ups1-Mdm35 heterodimer of the StARkin superfamily.

Women are more susceptible to death due to pneumonia when compared to men.

Lamins are found within the inner layer of the nuclear membrane of all cells.

β-sheet opening occurs during pleurotolysin pore formation.

p16INK4A degradation is  linked to an abnormal wound response caused by the microinvasive step of advanced Oral Potentially Malignant Lesions (OPMLs).

CCL19 is predominantly present within dLNs.

The G34R/V mutation does not create a hypomethylated phenotype at the H3K36 histone.

The G34R/V mutation creates a hypomethylated phenotype at the H3K36 histone.

The minor G allele of FOXO3 is related to less severe symptoms of Crohn's Disease.

Incidence of 10/66 dementia is higher than the incidence of DSM-IV dementia.

Incidence of 10/66 dementia is lower than the incidence of DSM-IV dementia.

Mutations in G-Beta protein GNB1 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.


A strong bias in the phage genome locations where the spacers were derived has been observed in many CRISPR subtypes that confer the immunity to phage.

Cardiac tissue-resident macrophages directly contribute to electrical activity.

Patients with microcytosis and higher erythrocyte count were more resistant to severe malarial anaemia when infected with Plasmodium falciparum.

The tissue surrounding the granuloma in an immune cell induces an anti-inflammatory immune response.

A 100g dose of chloroquine chemoprophylactic regimen results in retinal toxicity after 5-6 years of weekly intake.

In breast cancer, the loss of myoepithelial cells slows the transition of ductal carcinoma in situ to invasive carcinoma.

IFIT1 speeds viral replication by allowing for the proliferation of mis-capped viral RNAs.

The NF-κB essential modulator gene prevents intestinal inflammation by inhibiting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death.

The composition of myosin-II isoform switches from the A isoform to the B isoform during hematopoietic differentiation.

Immune complex triggered cell death leads to sequestration of oxidized mitochondrial DNA.

Female carriers of the Apolipoprotein E4 (APOE4) allele have decreased risk for dementia.

Nonhuman primates are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.

Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 encourage West Nile virus replication in cortical neurons.

Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 inhibit West Nile virus replication in cortical neurons.

Eilat virus (EILV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in nonhuman primates.

Understanding epigenetic regulation of replication is essential for the reational design of episomally replicating vectors.

Sequence conservation in gene regulatory regions between species is a poor predictor of conserved functionality.

Upon viral challenge, influenza-specific memory CD4+ T cells greatly diminish the early production of inflammatory chemokines in the lung.

In S. cerevisiae, the absence of RNA surveillance pathways reduces sensitivity to high iron conditions.

Upon viral challenge, influenza-specific memory CD4+ T cells greatly enhance the early production of inflammatory chemokines in the lung.


ALDH1 expression is associated with poorer prognosis for breast cancer primary tumors.

The peak incidence of fractures occurs during pubertal growth spurt in early adolescents.

Rapamycin increases the concentration of triacylglycerols in fruit flies.

Immune responses in immune cells are geographically segregated.

N348I mutations cause resistance to nevirapine.

Pyridostatin induces double-strand breaks accumulation.

Antidepressants increase the severity of migraines.

Nonsteroidal antinflammatory drugs show potential anticancer indications.

Deletion of ATM and Rad3 related protein is not predictive of acute tissue loss.

Microcin J25 inhibits nucleoside triphosphate (NTP) binding.

TNFAIP3 is a tumor enhancer in glioblastoma.

Normal expression of RUNX1 causes tumorsupressing effects.

TNFAIP3 is a glioblastoma tumor enhancer.

TNFAIP3 is a glioblastoma tumor suppressor.

BRCA 1 mutation carriers' risk of breast and ovarian cancer depends on where the mutation is located.

Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes epithelial damage.

Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes fibrosis.

Low expression of miR7a does not repress target genes or exert a biological function in ovaries.

GATA3 regulates cell cycle progression in bone marrow hematopoietic stem cells.


AMP-activated protein kinase (AMPK) activation reduces inflammation-related fibrosis in the lungs.

Prescribed exercise training improves quality of life.

Expression of oncolytic virus antigens as peptides permits additional protection against relapse.

Two variants of chromosome 6q21 are associated with radiation therapy-induced second malignancies in pediatric Hodgkin lymphoma patients.

Transplanted human glial progenitor cells can mature in their host animal.

Side effects associated with antidepressants do not represent a mortality risk to postmenopausal women.

A breast cancer patient's capacity to metabolize tamoxifen influences treatment outcome.

Ly6C hi monocytes have a higher inflammatory capacity than Ly6C lo monocytes.

Risk of cardiovascular events can be cut by a third by using antihypertensive drug therapy among hemodialysis patients.

Foxp3 enables the expression of transcriptional regulators implicated in memory T cell development.

LDL cholesterol has a causal role in the development of cardiovascular disease.

Increased lipolysis leads to higher P38 phosphorylation in adipose tissue.

Reduced levels of lipolysis leads to higher P38 phosphorylation in adipose tissue.

Cancer-associated fibroblasts (CAFs) interact with cancer cells to mediate formation and activation of CAFs.

The cytokine receptor which regulates chemotaxis and formation of lymph nodes is involved in production of myeloperoxidase in the left atrium.

High levels of CRP lead to a higher risk of exacerbations in chronic obstructive pulmonary disease (COPD).

Cancer-associated fibroblasts (CAFs) have no known interaction with cancer cells in the formation and activation of CAFs.

The effect of Lipopolysaccharides on kidney barrier function is dependent on inflammation levels.

Increased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm.


APOE4 expression in iPSC-derived neurons results in decreased tau phosphorylation.

Propriospinal interneurons that play a role in the plastic reorganization of spinal circuits are integral for recovery from spinal cord injury.

In transgenic mice harboring green florescent protein under the control of the Sox2 promoter, more than 50 percent of the cells with green florescent colocalize with cell proliferation markers.

Elevated cell-free mitochondrial DNA levels are associated with mortality.

Oxidative DNA damage activates STING signalling.

CD44v6 is not associated with constitutive and reprogrammed cancer stem cells driving cancer metastasis.

V-9302 inhibits antitumor responses by decreasing cell death and oxidative stress.

Physical activity level is associated with the difference in maximal oxygen consumption between black and white youth.

Distant CREs are less conserved among species.

Cytosolic proteins bind to iron-responsive elements on mRNAs coding for TFRC1.

IL-6 signaling plays a major role in atherosclerotic cardiovascular disease.

Converting apoE4 to apoE3 by gene editing worsens the pathology associated with apoE4 in human iPSCderived neurons.

Converting apoE4 to apoE3 by gene editing prevents the pathology associated with apoE4 in human iPSCderived neurons.

Foxp3 represses the expression of transcriptional regulators implicated in memory T cell development.

Mice lacking Sirt1 in Sf1-expressing neurons have increased susceptibility to diet-induced obesity and insulin resistance.

MFGE8 regulates fat absorption by binding to av-Beta3 and av-Beta5 integrins.

Foxp3 enables the expression of transcriptional regulators implicated in memory T cell development.

Reduced phosphorylation of PP2A suppresses HDAC4 dephosphorylation.


ART has no effect on the infectiveness of HIV-positive people.

Differentiated E2f-1, -2, -3 TKO cells in the intestine do not exhibit apoptosis.

KLF4 is necessary for VSMCs to gain genetic characteristics of other cell types within atherosclerotic lesions.

Self-advocacy training is effective at decreasing homelessness.

Pyridostatin deregulates G2/M progression.

Venules have less significant tunica adventitia than arterioles.

Inhibiting glucose-6-phospate dehydrogenase improves lipogenesis by deactivating LKB1-AMPK signaling.

The World Health Organization's (WHO) data collection process is biased downward by unequal selection of larger outbreaks.

NR5A2 does not play a role in development of endometrial tissues.

Klf4 is not required for proper myeloid cell differentiation.

In British Men, haplogroup I increases risk of cardiovascular disease by 50%.

ART substantially reduces infectiveness of HIV-positive people.

Having a main partner worsens HIV outcomes.

Perigenital skin is not the primary site of HIV acquisition.

Patients in stable partnerships have a slower progression from HIV to AIDS.

Exhaustion of B cells contributes to poor Ab response in HIV-infected individuals.

Patients in stable partnerships progress from HIV to death at the same rate as patients not in partnerships.

Chronic HIV stimulation of B cells leads to the premature exhaustion of B cells.

Having a main partner improves HIV outcomes.

A low percentage of hematopoietic progenitor cells are susceptible to HIV-1 infection ex vivo.


ART substantially reduces infectiveness of HIV-positive people.

A deficiency of vitamin B6 decreases blood levels of homocysteine.

Post-transcriptional handling of mitochondrial transcripts occurs in mitochondrial RNA granules.

Antimicrobial agents are more effective due to the pressure of antimicrobial usage.

In breast cancer, the loss of myoepithelial cells promotes the transition of ductal carcinoma in situ to invasive carcinoma.

There is no increased risk of hypospadias with clomiphene.

Reduced responsiveness to interleukin-2 in regulatory T cells is associated with autoimmune diseases such as Type 1 Diabetes.

Pioneer factor OCT3/4 interacts with major chromatin remodeling factors.

Cis-acting lncRNAs control the expression of genes that are positioned in the vicinity of their transcription sites.

Lack of FGF21 in mice leads to reduced lifespan.

The one-child policy has created a hospitable environment for female infants.

Antiretroviral therapy increases rates of tuberculosis across a broad range of CD4 strata.


ATF4 is a general endoplasmic reticulum stress marker.

The US health care system can save up to $5 billion if 7% of patients waiting for kidney transplants participate in the optimized national kidney paired donation program.

B cells go though plasmablast differentiation and antibody production by continuous expression of EBI2.

The minor G allele of FOXO3 up-regulates IL-10.

The latent infection of myeloid cells with human cytomegalovirus induces a number of changes in gene expression.

Walking in traffic areas in London improves lung function in elderly adults.

Pyridostatin decreases telomere fragility in BRCA2-deficient cells.

ATM and Rad3 related protein are critical for sensing DNA damage.

Tonic signaling from the scFv prevents constitutive stimulation.

Higher plasma levels of I-carnitine, when associated with trimethylamine N-oxide, are positively correlated with cardiovascular events in humans.

NR5A2 is important in reverse cholesterol transport in humans.

BiP is a general endoplasmic reticulum stress marker.

CHOP is a general endoplasmic reticulum stress marker.

4-PBA treatment decreases endoplasmic reticulum stress in response to general endoplasmic reticulum stress markers.

4-PBA treatment raises endoplasmic reticulum stress in response to general endoplasmic reticulum stress markers.

Ribosomal protein (RP) expression is controlled in part by stress-activated regulators.

Deltex has no known interactions with eIF3f.

MFGE8 regulates fat absorption by binding to av-Beta3 and av-Beta5 integrins.

KRT17 modulates the expression of the transcriptional regulator AIRE in diseased epithelia.

Mice lacking Sirt1 in Sf1-expressing neurons have increased susceptibility to diet-induced obesity and insulin resistance.


ATM and Rad3 related protein are critical for sensing DNA damage.

Deletion of ATM and Rad3 related protein is not predictive of acute tissue loss.

Taxation of sugar-sweetened beverages reduced the incidence rate of type II diabetes in India.

Approximately 250,000 people are infected with human T-cell lymphotropic virus type 1 in the United Kingdom.

Immune responses in immune cells are geographically segregated.

Post-transcriptional handling of mitochondrial transcripts occurs in mitochondrial RNA granules.

LDL cholesterol has a causal role in the development of cardiovascular disease.

Smc5/6 engagment halts the activation of SUMO E3 ligase Mms21 by ATP-dependent remolding.

Increased mobility of retrotransposons is assosciated with mutation and higher tumorigenesis rates.

Lamins are found within the inner layer of the mitochondrial membrane of all cells.

Persister cells provide relapse resistance in cancer patients.

ATM and Rad3 related protein have no role in sensing DNA damage.

Deletion of ATM and Rad3 related protein leads to acute tissue loss.

Activated Cdk5 phosphorylates the ATM protein in response to DNA damage.

RAD52 is involved in break-induced DNA replication (BIR).

Toll-like receptor (TLR) signaling is involved in the pathogenesis of human MDS.

Gpr124 suppresses BBB breakdown in mouse models of ischemic stroke.

Replacement of OCT4 and SOX2 genes with GATA3 has the ability to reprogram human cells.

CD28 signals regulate trafficking of murine auto-reactive T cells into target tissues.


ATM and Rad3 related protein have no role in sensing DNA damage.

Radioiodine treatment of non-toxic multinodular goitre increases thyroid volume.

Cnn1 recruitment varies with cell cycle timing.

A deficiency of vitamin B6 decreases blood levels of homocysteine.

Kir7.1 modulates channel activity by the G protein-coupled melanocortin-4 receptor (MC4R) in the paraventricular nucleus of the hypothalamus.

Whole brain radiotherapy increases the occurrence of new brain metastases.

Ethanol stress increases the expression of PSP in bacteria.

Pyridostatin decreases telomere fragility in BRCA2-deficient cells.

Treatment with the EC uptake inhibitor AM404 resulted in a dose-dependent decrease in the expression of immobility.

V-9302 inhibits antitumor responses by decreasing cell death and oxidative stress.

Replacement of OCT4 and SOX2 genes with GATA3 is not capable of reprogramming human cells.


AZT given with ribavirin increases anemia.

Physical activity does not improve cognitive function in individuals with Alzheimers.

Citrullinated proteins externalized in neutrophil extracellular traps act indirectly to perpetuate the inflammatory cycle via induction of autoantibodies.

Upregulation of PD1 causes the downmodulation of Satb1.

KRT17 modulates the expression of the transcriptional regulator AIRE in diseased epithelia.

HOXB4 facilitates HSC expansion when co-cultured with HSCs.

Cholesterol loading induces KLF4 expression in VSMCs, resulting in the expression of pro-inflammatory cytokines.

Induced hepatic stem cells possess the potential to differentiate into hepatocytic cells.

Progerin induces premature aging in stem cells.

Mutant mice lacking SVCT2 have severely reduced ascorbic acid levels in both brain and adrenals.

Excess gestational weight gain is associated with obesity-related pregnancy outcomes.

Antidepressants increase the severity of migraines.

Taking anti-depresents is associated with a decrease in the Aβ level in the brain of experimental animals.

Alirocumab treatment reduces apo(a) fractional clearance rate.

Antidepressants reduce the severity of migraines.

Side effects associated with antidepressants increases risk of stroke.

Antiretroviral therapy increases rates of tuberculosis across a broad range of CD4 strata.

Side effects associated with antidepressants lower risk of myocardial infarction.

A deficiency of folate increases blood levels of homocysteine.

The most prevalent adverse events to Semaglutide are gastrointestinal.


Activated Cdk5 phosphorylates the ATM protein in response to DNA damage.

Nonsteroidal antinflammatory drugs are ineffective as cancer treatments.

Prescribed exercise training improves quality of life.

The repeat-variable diresidue (RVD) in the loop of Transcription-Activator Like (TAL) effectors specifies the nucleotides-amino acid contact at the target promoter element.

Folate and vitamin B12 levels influence the association between homocysteine and preeclampsia.

Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 inhibit West Nile virus replication in cortical neurons.

eRNAs influence is linked to senescence, aging, and carcinogenesis.

Active Ly49Q induces neutrophil polarization.

MafA phosphorylation decreases its ubiquitination.

Physical activity level is associated with the difference in maximal oxygen consumption between black and white youth.

Taking anti-depresents is associated with a decrease in the Aβ level in the brain of experimental animals.

Activated Cdk5 regulates DNA damage-induced neuronal death.

Deletion of ATM and Rad3 related protein leads to acute tissue loss.

ATM and Rad3 related protein have no role in sensing DNA damage.

ATM and Rad3 related protein are critical for sensing DNA damage.

Deletion of ATM and Rad3 related protein is not predictive of acute tissue loss.

CD28 signals regulate trafficking of murine auto-reactive T cells into target tissues.

ITAM phosphorylation allows for the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).

Binding of p53 to enhancer regions (p53BERs) regulates the activity of p53 transcription and cell cycle arrest through the production of p53-dependent eRNAs.

Toll-like receptor (TLR) signaling is involved in the pathogenesis of human MDS.


Activated Cdk5 regulates DNA damage-induced neuronal death.

Converting apoE4 to apoE3 by gene editing prevents the pathology associated with apoE4 in human iPSCderived neurons.

Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection decreases dissemination of Salmonella Typhimurium from the gut.

HOXB4 is a highly expressed component of cellular secretome from fetal liver cell populations.

Walking in traffic areas in London improves lung function in elderly adults.

siRNA knockdown of A20 slows tumor progression in an in vivo murine xenograft model.

Ribosomal protein (RP) expression is controlled in part by stress-activated regulators.

The G34R/V mutation does not create a hypomethylated phenotype at the H3K36 histone.

A diminished ovarian reserve does not solely indicate infertility in an a priori non-infertile population.

Cis-acting lncRNAs control the expression of genes that are positioned in the vicinity of their transcription sites.

FoxO3a activation in neuronal death is inhibited by reactive oxygen species (ROS).

Activation of PPM1D enhances p53 function.

CD28 initiates tonic signaling in conventional T cells, which causes an exhaustion phenotype and limited efficiency.

Up-regulation of the p53 pathway and related molecular events speeds cancer progression.

PD-1 triggering on monocytes enhances IL-10 production by monocytes.

IL-10 production by monocytes inhibits CD4 + T cell response.


Activation of PPM1D enhances p53 function.

Adult tissue-resident macrophages stem from the embryonal yolk sac and fetal liver.

Cellular clocks are not predictive of mitosis timing in NIH 3T3 cells.

Treatment with a protein named FN impairs regenerative abilities of aged muscles.

In S. cerevisiae, the absence of RNA surveillance pathways reduces sensitivity to high iron conditions.

Removal of H3K9me3 improves reprogramming efficiency in human somatic cell nuclear transfer experiments.

Gastric infection with Helicobacter pylori increases risk of gastric cancer in humans.

Sympathetic nerve activity is elevated throughout normal pregnancy.

The Snf1 complex regulates carbon and energy metabolism in baker's yeast (Saccharomyces cerevisiae).

Healthy volunteers exhibit rapid and transient increase of cellular ATP after being bolus-injected with fructose.

p16INK4A degradation is encoded by CDKN2A.

MeCP2 influences the synaptic maturation of neurons.

Activated Cdk5 phosphorylates the ATM protein in response to DNA damage.

Upregulation of PD1 causes the downmodulation of Satb1.

Upregulation of PD1 causes the upregulation of Satb1.


Activation of the Rac1 homolog CED-10 kills viable cells in SRGP-1 mutant Caenorhabditis elegans.

N348I mutations reduce resistance to nevirapine.

EG7 tumors can be killed by systemic oxaliplatin primed CD8+ T cells from the tumor-draining lymph node cells.

COPI coatmer is involved in lipid homeostasis.

Depletion of nitric oxide is responsible for vasospasm.

Homozygous deletion of murine Sbds gene from osterix-expressing mesenchymal stem and progenitor cells (MPCs) induces oxidative stress.

Microglia are an innate immune cell type of the peripheral nervous system.

Broadly HIV-1 Neutralizing Antibodies (bnAb) 10EB have no affinity for phospholipids.

Neutrophils produce IL-1β in response to large particles.

ART substantially reduces infectiveness of HIV-positive people.

Ca2+ cycling is a UCP1-independent thermogenic mechanism.

Activated Cdk5 regulates DNA damage-induced neuronal death.

The Snf1 complex regulates carbon and energy metabolism in baker's yeast (Saccharomyces cerevisiae).

siRNA knockdown of A20 slows tumor progression in an in vivo murine xenograft model.

The PRDM1 gene is a key determinant of primordial germ cells.

Localization of PIN1 in the roots of Arabidopsis requires VPS9a

Gpr124 suppresses BBB breakdown in mouse models of ischemic stroke.

In a naive state, blocking Wingless-Int-1 secretion from mouse embryonic stem cells inhibits self-renewal of the mouse embryonic stem cells.


Activator-inhibitor pairs are provided ventrally by Xrl-sizzled.

HAND2 methylation is a key step in early endometrial carcinogenesis.

Increased purity of cytoplasmic membranes isolated from overexpressors is indicated by stronger spots for OmpF in 2D BN-PAGE gels.

Systemic lupus erythematosus is a risk factor for cardiovascular disease.

Pro-inflammatory cytokines are up regulated during tumor development.

KLF4 is necessary for VSMCs to gain genetic characteristics of other cell types within atherosclerotic lesions.

mcm 5 s 2 U is required for proper decoding of NNR codons in eukaryotes.

Insulin effects appetite via ventral tegmental neurons.

In the UK, drowning affects boys and girls equally.

At least 85% of patients exposed to radiation have activated markers of myofibroblasts.

Carriers of HNF4A mutations are at reduced risk for diabetes.

Drosophila supracellular actomyosin structures are found at boundaries in wing imaginal discs.

The C-type lectin receptor (CLEC-2) rearranges the actin cytoskeleton in dendritic cells to promote efficient motility along stromal surfaces.

Upregulation of dynein in Drosophila neurons increases the number of microtubule plus-ends growing toward the cell body of each neuron.

ITAM phosphorylation allows for the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).

IFI16 impedes STING phosphorylation and translocation, resulting in reduced activation of STING.

C2 works synergistically with A-769662 to activate dephosphorylated AMPK.

Beta-band coherence is enhanced for visible stimuli over invisible stimuli.

Beta-band coherence is diminished for visible stimuli over invisible stimuli.

During the primary early antibody response activated B cells migrate toward the inner-and outer follicular areas where oxysterol accumulation is generated by stromal cells.


Active H. pylori urease has a polymeric structure consisting of five distinct subunits.

ScPif1p has reduced binding ability to G-rich ssDNA compared to non-G-rich ssDNA.

DUSP4 downregulation deactivates the Ras-ERK pathway

Chinese individuals with TT homozygosity in the MTHFR gene are more vulnerable to strokes caused by low levels of folate intake.

Higher plasma levels of I-carnitine, when associated with trimethylamine N-oxide, are negatively correlated with cardiovascular events in humans.

Exercise reduces cancer mortality rates among Chinese citizens.

Major vault protein regulates sorting of tumor suppressive miR-193a into EVs.

KRT17 modulates the expression of the transcriptional regulator AIRE in diseased epithelia.

Phase information is useful for predicting donor-recipient matches in organ transplantation.

Suboptimal nutrition is a leading cause of premature death

CCL19 is predominantly present within dLNs.

The deamination of cytidine to uridine on the minus strand of viral DNA can inactivate the viral genome by inducing G-to-A mutations.

The composition of myosin-II isoform switches from the A isoform to the B isoform during hematopoietic differentiation.

Formation of N-terminal pyroglutamate by glutamine cyclase (GC) competes with NTAQ1 for Nt-Gln substrates.

Emodin forms hydrogen bonds with residues involved in PGAM1 substrate binding.

Thiopurine active metabolites can be catabolized through dephosphorylation of thioguanine nucleotides.

The predominant localization of Linc00173 is in mononuclear macrophage nuclei.

The Snf1 complex regulates carbon and energy metabolism in baker's yeast (Saccharomyces cerevisiae).

Ethanol stress reduces the expression of SRL in bacteria.


Active Ly49Q induces neutrophil polarization.

Having a main partner improves HIV outcomes.

Treatment with a protein named FN impairs regenerative abilities of aged muscles.

Cnn1 recruitment varies with cell cycle timing.

Therapeutics receiving accelerated approval encounter a lower frequency of post-marketing safety events

The amount of publicly available DNA data doubles every 10 months.

Cholesterol loading induces KLF4 expression in VSMCs, resulting in the expression of pro-inflammatory cytokines.

The composition of myosin-II isoform switches from the A isoform to the B isoform during hematopoietic differentiation.

Intra-cerebroventricular infusion of amyloid-β oligomers increases expression of fibronectin type-III domain-containing protein 5 mRNA in mice hippocampi.

Ribosomopathies have a high degree of cell and tissue specific pathology.

JMJD6 slows the hydroxylation of C-terminal lysine

Active Ly49Q prevents neutrophil polarization.

Ly49Q directs the organization of neutrophil polarization by regulating membrane raft functions.

Blocking the interaction between TDP-43 and respiratory complex I proteins ND3 and ND6 prevents TDP-43-induced neuronal loss.

Neutrophils produce IL-1β in response to large particles.

Activated Cdk5 phosphorylates the ATM protein in response to DNA damage.

ITAM phosphorylation allows for the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).

Activation of PPM1D enhances p53 function.


Active Ly49Q prevents neutrophil polarization.

NAC destabilizes NO to increase the effect of contrast agents on renal functions.

There is no increased risk of hypospadias with clomiphene.

Increased mobility of retrotransposons does not lead to mutation and higher tumorigenesis rates.

Chinese individuals with TT homozygosity in the MTHFR gene are less vulnerable to strokes caused by low levels of folate intake.

General exercise therapy is more effective than rotator cuff exercises in reducing pain and improving function of the shoulder.

British female students are bullied more than British male students.

Tumor development occurs in conjunction with upregulation of pro-inflammatory cytokines.

Lamins are found within the inner layer of the nuclear membrane of all cells.

Mice without IFN-γ or its receptor are highly susceptible to EAM induced with α-MyHC/CFA.

Nonhuman primates are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.

H4 G94P proteins inhibit chromatin assembly, which decreases free histones.

Low expression of miR7a does not repress target genes or exert a biological function in testis.

Formation of N-terminal pyroglutamate by glutamine cyclase (GC) competes with NTAQ1 for Nt-Gln substrates.


Active caspase-11 participate in regulating phagosome-lysosome fusion.

Origin gross domestic product(GDP) is positively related to dengue virus (DENV-1) diffusion in air traffic shipments.

Human embryonic stem cells have the capacity to give rise to differentiated progeny representative of all three embryonic germ layers.

Long chain polyunsaturated fatty acids supplementation is associated with lower rates of atopic eczema at 1 year.

Prescribed exercise training improves quality of life.

Exercise increases cancer mortality rates among Chinese citizens.

Inside the body, falciparum parasites reproduce asexually.

Intake of folic acid (FA) and vitamin B6 (VB6) increases levels of homocysteine.

CDK6 shows impaired binding to loss-of-function variants of p18 INK4C.

Women are more susceptible to death due to pneumonia when compared to men.

NAC destabilizes NO to increase the effect of contrast agents on renal functions.

Active caspase-11 protein promotes pyroptosis.

Binding of p53 to enhancer regions (p53BERs) regulates the activity of p53 transcription and cell cycle arrest through the production of p53-dependent eRNAs.

Comparative transcriptome analysis identified new platelet proteins with structural features suggesting a role in platelet function.

ER-localized phosphatase Sac1 processes PI4P through coordination with OSBP and the endosome-localized protein sorting nexin 2.

JMJD6 catalyzes the hydroxylation of C-terminal lysine and supresses transcriptional activity.

Intramembrane cleavage by signal peptide peptidase aids in the degradation of proteins with a complex membrane orientation.

Distant CREs are important for transcriptional regulation.

Foxp3 enables the expression of transcriptional regulators implicated in memory T cell development.


Active caspase-11 protein promotes pyroptosis.

In domesticated populations of Saccharomyces cerevisiae, segmental aneuploidy is very common.

The PPR MDA5 has twenty N-terminal CARD domains.

Intake of folic acid (FA) and vitamin B6 (VB6) reduces levels of homocysteine.

Gpr124 suppresses BBB breakdown in mouse models of ischemic stroke.

Pro-inflammatory cytokines are up regulated during tumor development.

Foxk2 regulates autophagy genes in muscle cells and fibroblast cells.

The myocardial cell lineage originally develops from cardiac progenitors of exclusively endodermal origin.

Rising temperatures caused by global warming increases risk of dengue fever transmission.

Side effects associated with antidepressants increases risk of stroke.

Distant CREs are important for transcriptional regulation.

H4 G94P proteins induce degradation of free histones via Rad53-dependent mechanisms.

Major vault protein regulates sorting of tumor suppressive miR-193a into EVs.

H4 G94P proteins suppress degradation of free histones via Rad53-dependent mechanisms.

Reduced phosphorylation of PP2A increases HDAC4 dephosphorylation by enhancing PP2A-HDAC4 interaction.

Decrease of p62 in prostate tumor stroma results in defective autophagy.

APOE4 expression in iPSC-derived neurons results in decreased tau phosphorylation.

Mitochondria play a major role in apoptosis.


Acute ablation of KRAS causes severe growth impairment.

Lack of FGF21 in mice slows the rate of atherosclerotic plaque formation.

H4 G94P proteins suppress degradation of free histones via Rad53-dependent mechanisms.

Induced hepatic stem cells possess the potential to differentiate into cholangiocytic cells.

Nigerian physicians constitue the largest component of sub-Saharan Africa-trained physicians in the United States.

Exercise reduces cancer mortality rates among Chinese citizens.

Eilat virus (EILV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in nonhuman primates.

Increased lipolysis leads to higher P38 phosphorylation in adipose tissue.

Acute ablation of Snail in the embryonic cortex affects the proliferation and number of embryonic cortical precursors.

The H2A-H2B eviction defect is compensated for by other histone chaperone(s).

During non-homologous end joining, the ligation step is not as tolerant of disrepairs and other distortions when joining 3' of strand breaks as compared to 5' strand breaks.

Upon developing tyrosine-kinase inhibitor resistance, new mutations in epidermal growth factor receptors emerge and cause treatment failure.

B3-Galectin decreases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR.

B3-Galectin increases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR.

aPKCz causes tumour suppression by affecting glutamine metabolism.

Taking 400mg of α-tocopheryl acetate in combination with vitamin C reduces the risk of prostate cancer.

Autophagy deficiency in the liver increases vulnerability to insulin resistance.

Taking 400mg of α-tocopheryl acetate does not prevent prostate cancer.

Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes fibrosis.

AMP-activated protein kinase (AMPK) activation reduces inflammation-related fibrosis in the lungs.


Acute ablation of Snail in the embryonic cortex affects the proliferation and number of embryonic cortical precursors.

Vitamin D is an important factor in the relationship between calcium and parathyroid hormone.

The peak incidence of fractures occurs during pubertal growth spurt in early adolescents.

Epidemiological disease burden from noncommunicable diseases is more prevalent in high economic settings.

Tonic signaling from the scFv is amplified by MyD88/CD40.

Moderate consumption of candy and chocolate reduces the risk of cardiovascular disease (CVD).

Human embryonic stem cells give rise to cell types from the outer embryonic germ layer, but not the other two layers.

The proliferative capacity of neural progenitors differs across species.

The minor G allele of FOXO3 up-regulates IL-10.

R2D2 stops miRNA production by increasing the selectivity of Dcr2 for long dsRNA.

Cellular differentiation of embryonic stem cells is accompanied by changes in replication timing, transcription and nuclear localization.

MeCP2 influences the synaptic maturation of neurons.

Nuclear transfer from adult human fibroblasts to human oocytes can give rise to blastocysts containing expandable pluripotent cells.

Alteration of origin firing causes changes in termination zones of Okazaki fragments.

Activation of the Rac1 homolog CED-10 kills viable cells in SRGP-1 mutant Caenorhabditis elegans.

The deregulated and prolonged activation of monocytes has deleterious effects in chronic infectious conditions.

Differentiation of progenitor cells to myeloid cells is skewed upon activation of insulin signaling.

Differentiation of progenitor cells to myeloid cells is skewed when insulin signaling is suppressed.

Upregulation of dynein in Drosophila neurons increases the number of microtubule plus-ends growing toward the cell body of each neuron.


Addition of BMP4, activin A, CHIR99021, and SU504 to reprogramming fibroblasts generates, expands and maintains cardiovascular progenitor cells (CPCs)

Bariatric surgery reduces postmenopausal breast cancer.

Patients with panic anxiety show decreased CSF levels of hypocretin.

Gastric infection with Helicobacter pylori increases risk of gastric cancer in humans.

The myocardial cell lineage originally develops from cardiac progenitors of exclusively endodermal origin.

Normal granulomas form in the presence of TNF in Zebrafish.

Microglia are an innate immune cell type of the central nervous system.

Taking 400mg of α-tocopheryl acetate does not prevent prostate cancer.

Retinoic acid receptor-related orphan receptor gamma (RORγ) is a therapeutic target for castration-resistant prostate cancer (CRPC)

Venules have less significant tunica adventitia than arterioles.

B3-Galectin decreases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR.

Fibroblast Growth Factor is a ligand which signals through receptor tyrosine kinases.

Fibroblast growth factor 21 protects against atherosclerosis by modulating adiponectin and SREBP2 levels.

Cancer-associated fibroblasts (CAFs) interact with cancer cells to mediate formation and activation of CAFs.

Cancer-associated fibroblasts (CAFs) are constituents of tumor microenvironments

Cancer-associated fibroblasts (CAFs) have no known interaction with cancer cells in the formation and activation of CAFs.

Ectopic expression of Sall4, Nanog, Esrrb, and Lin28 generates induced pluripotent stem cells from mouse embryonic fibroblasts more efficiently than other factor combinations.

The PPR MDA5 has twenty N-terminal CARD domains.

Pioneer factor OCT3/4 interacts with major chromatin remodeling factors.


Adult tissue-resident macrophages are seeded before birth.

HNF4A mutations are associated with macrosomia in infancy.

Enhanced early production of inflammatory chemokines damages viral control in the lung.

Input from  mental and physical health care professionals is not effective at decreasing homelessness.

Chenodeoxycholic acid treatment increases brown adipose tissue activity.

JMJD6 slows the hydroxylation of C-terminal lysine

Progerin induces premature aging in stem cells.

Oxidative DNA damage inhibits STING signalling.

De novo assembly of sequence data has fewer specific contigs than unassembled sequence data.

Sepsis related mortality has remained stable between 2009-2014.

NR5A2 does not play a role in development of endometrial tissues.

Adult tissue-resident macrophages possess a self-renewing capacity.

Adult tissue-resident macrophages stem from the embryonal yolk sac and fetal liver.

Bone marrow cells don't contribute to adult macrophage compartments.

Human embryonic stem cells give rise to cell types from the outer embryonic germ layer, but not the other two layers.

miRNAs regulate a unique suite of mRNAs to maintain homeostasis in cells.

Differentiation of progenitor cells to myeloid cells is skewed when insulin signaling is suppressed.

Differentiation of progenitor cells to myeloid cells is skewed upon activation of insulin signaling.


Gastric lavage is an effective treatment for acute paraquat poisoning.

A low percentage of hematopoietic progenitor cells are susceptible to HIV-1 infection ex vivo.

Concentrations of SNV and CNV in stem-cell regulatory elements and binding sites of transcription factors in iPSC-lines are distinct from their founding cells.

Scapular stabilizer exercises are more effective than general exercise therapy in reducing pain and improving function of the shoulder.

The PPR MDA5 has twenty N-terminal CARD domains.

Ultrasound guidance significantly reduces the number of needle insertion attempts necessary for a given procedure.

Acute ablation of KRAS causes severe growth impairment.

Differentiated E2f-1, -2, -3 TKO cells in the intestine do not exhibit apoptosis.

The minor G allele of FOXO3 up-regulates IL-10.

Nonhuman primates are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.


Adult tissue-resident macrophages possess a self-renewing capacity.

For every 1,000 children with cerebral palsy, more than 300 of them are premature or underweight at birth.

Microcin J25 encourages nucleoside triphosphate (NTP) binding.

Glycan adaptation is rarely observed in the B-cell repertoire.

Klf4 is not required for proper myeloid cell differentiation.

Tuberculosis-induced granulomas express different immune system protein signatures than the surrounding tissue.

Oxidative phosphorylation is one of the primary glycometabolic pathways in cells.

Up-regulation of the p53 pathway and related molecular events speeds cancer progression.

Pyridostatin decreases telomere fragility in BRCA2-deficient cells.

The morphology change from large white adipocytes to small brown adipocytes is a sign of increased energy expenditure potential in white adipose tissue.

RANK-RANKL pathway signalling is linked to development of Aire-expressing medullary thymic epithelial cells.

Cardiac tissue-resident macrophages directly contribute to electrical activity.

Mitochondria play a major role in energy production.

0-dimensional biomaterials lack inductive properties.

The proliferative capacity of progenitors is regulated cell-autonomously.


Adult tissue-resident macrophages stem from the embryonal yolk sac and fetal liver.

The innate immune response struggles to remove small numbers of parasites.

1-1% of colorectal cancer patients are diagnosed with regional or distant metastases.

Omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegetarians.

Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission.

GATA3 regulates cell cycle progression in bone marrow hematopoietic stem cells.

Beta-band coherence is diminished for visible stimuli over invisible stimuli.

Increase of p62 in prostate tumor stroma results in defective autophagy.

Deletion of ATM and Rad3 related protein leads to acute tissue loss.

Inhibiting focal adhesion formation enables cells to convert mechanical strain into eventual scarring.

Charcoal shows no benefit for acute paraquat poisoning.

Human embryonic stem cells give rise to cell types from all three embryonic germ layers.

Human embryonic stem cells have the capacity to give rise to differentiated progeny representative of all three embryonic germ layers.

Microglia are an innate immune cell type of the central nervous system.


Participants who quit smoking reduce lung cancer risk by approximately 50%.

Primary pro-inflammatory cytokines suppress secondary pro- and anti-inflammatory mediators.

Scapular stabilizer exercises are more effective than general exercise therapy in reducing pain and improving function of the shoulder.

In rhesus macaques, daily subcutaneous injections of emtricitabine are ineffective at protecting against rectally transmitted simian-human immunodeficiency virus.

Cancer cells can stimulate the accumulation of intra-tumoural myeloid-derived suppressor cells by promoting granulocyte colony stimulating factor production.

Sequence conservation in gene regulatory regions between species is a poor predictor of conserved functionality.

Lamins are associated with nuclear membrane structure maintenance.

Expression of oncolytic virus antigens as peptides makes relapse more likely.

The number of unfertilized oocytes in mated hermaphrodites increases with age.


Aged patients are less susceptible to ischaemia/reperfusion injury.

cSMAC formation represses weak ligand signalling.

Activated Cdk5 regulates DNA damage-induced neuronal death.

M. stadtmanae does not induce ASC speck formation in BlaER1 monocytes.

Cnn1 recruitment varies with cell cycle timing.

Intramembrane cleavage by signal peptide peptidase aids in the degradation of proteins with a complex membrane orientation.

Including pharmacists in rounding teams reduces the incidence of adverse drug events (ADEs).

IL-6 signaling plays a major role in atherosclerotic cardiovascular disease.

Cost effectiveness evaluations based on cRCT data lack external validity.

Bacterial meningitis can be diagnosed on the basis of positive cerebrospinal fluid (CSF) cultures.

Localization of PIN1 in the roots of Arabidopsis requires VPS9a

Aged patients are more susceptible to ischaemia/reperfusion injury.

Nonhypertensive people who are 55 years old have a 90% chance of developing hypertension during their lifetime.

Diabetic patients with acute coronary syndrome experience decreased short-term and long-term risk for bleeding events.

Treatment with a protein named FN impairs regenerative abilities of aged muscles.

Risk of cardiovascular events can be cut by a third by using antihypertensive drug therapy among hemodialysis patients.

Female carriers of the Apolipoprotein E4 (APOE4) allele have increased risk for Alzheimer's disease.

Physical activity does not improve cognitive function in individuals with Alzheimers.

In young and middle-aged adults, current or remote uses of ADHD medications increase the risk of serious cardiovascular events.

Individuals with Alzheimers who participate in six months of physical activity improve cognitive function for up to 18 months.


Aged patients are more susceptible to ischaemia/reperfusion injury.

Certain immunomodulator-human dialyzable leukocyte extract (hDLE) peptides are recognized by toll-like receptors (TLRs) on macrophages and dendritic cells.

Bone Marrow (BM) transplantation is used to treat acute myeloid leukemia (AML)

Kir7.1 modulates channel activity by the G protein-coupled melanocortin-4 receptor (MC4R) in the paraventricular nucleus of the hypothalamus.

90% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.

Women with a lower birth weight are more likely to develop breast cancer later in life.

PKG-la plays an essential role in expression of spinal long term potentiation in PGK-la knockout mice.

Rising temperatures caused by global warming lowers the risk of dengue fever transmission.

53% of perinatal mortality is due to low birth weight.