For every 1,000 children with cerebral palsy, more than 300 of them are premature or underweight at birth.

The peak incidence of fractures occurs during pubertal growth spurt in early adolescents.

The density of cytokine receptor bearing cells affects the distance over which cytokines act.

GATA3 regulates self-renewal capacity in bone marrow hematopoietic stem cells.

Including pharmacists in rounding teams does not alter the incidence of adverse drug events (ADEs).

Healthy volunteers exhibit rapid and transient increase of cellular ATP after being bolus-injected with fructose.

Therapeutics receiving accelerated approval encounter a lower frequency of post-marketing safety events

Prescribed exercise training improves quality of life.

Pseudogene PTENP1 encodes a transcript that regulates PTEN expression.

Diabetes remission occurs less in people treated with conventional therapy than in people treated with laparoscopic adjustable gastric banding surgery.

Vaccinating the gastrointestinal tract induces protection of rectal and vaginal mucosa.

53% of perinatal mortality is due to low birth weight.

10% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.

90% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.

Nonhypertensive people who are 55 years old have a 90% chance of developing hypertension during their lifetime.

There was an estimated 30 million cases of pneumonia in young children worldwide in 2010.

Women with a lower birth weight are more likely to develop breast cancer later in life.

A mutation in HNF4A leads to an increased risk of developing diabetes by the age of 14 years.

The proportion of people with visual difficulty is two times higher in low-income countries than in high-income countries.

The peak incidence of fractures occurs in toddlers.


Forkhead 0 (fox0) transcription factors are involved in apoptosis.

The RANK-RANK-Ligand (RANKL) pathway is involved in the development of Aire-expressing medullary thymic epithelial cells (mTECs).

Comparative transcriptome analysis identified new platelet proteins with structural features suggesting a role in platelet function.

Decreased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm.

Cancer-associated fibroblasts (CAFs) are constituents of tumor microenvironments

Approximately 250,000 people are infected with human T-cell lymphotropic virus type 1 in the United Kingdom.

1-1% of colorectal cancer patients are diagnosed with regional or distant metastases.

Stiff substrates encourage mesodermal differentiation by degrading beta-catenin in an integrin-dependent manner.

Chlamydia trachomatis is most prevalent in the UK among sexually-experienced individuals aged 16 to 24.

Lmna knock-in models are appropriate for testing therapeutic approaches against Hutchinson-Gilford progeria syndrome (HGPS).

Forkhead 0 (fox0) transcription factors are involved in cellular differentiation.

Foxp3 enables the expression of transcriptional regulators implicated in memory T cell development.

Foxk2 regulates autophagy genes in muscle cells and fibroblast cells.

Foxp3 represses the expression of transcriptional regulators implicated in memory T cell development.

FoxO3a activation in neuronal death is inhibited by reactive oxygen species (ROS).

Mitochondria play a major role in apoptosis.

The minor G allele of FOXO3 downregulates pro-inflammatory cytokines.

The gene daf-16, which encodes forkhead Box O (FOXO), is required for all phenotypes associated with reduced insulin/insulin-like growth factor (Igf) signaling.

The minor G allele of FOXO3 up-regulates IL-10.


Forkhead 0 (fox0) transcription factors are involved in cellular differentiation.

The first MBT repeat of the four malignant brain tumor (4MBT) domain of Drosophila's Sfmbt and of the orthologous mammalian L3MBTL2 is required for the interaction with the spacer region of Drosophila's Pleiohomeotic (Pho) or its human ortholog YY1.

The density of cytokine receptor bearing cells has no effect on the distance over which cytokines act.

Taxation of sugar-sweetened beverages reduced the incidence rate of type II diabetes in India.

The number of unfertilized oocytes in mated hermaphrodites increases with age.

Low expression of miR7a does not repress target genes or exert a biological function in testis.

Input from  mental and physical health care professionals is not effective at decreasing homelessness.

aPKCz causes tumour suppression by affecting glutamine metabolism.

Activator-inhibitor pairs are provided ventrally by Xrl-sizzled.

Notch signaling occurs between tumor cells and stromal cells.

90% of patients with melanoma and an objective response to PD-1 blockade will experience a progression in their melanoma.

Binding of p53 to enhancer regions (p53BERs) regulates the activity of p53 transcription and cell cycle arrest through the production of p53-dependent eRNAs.

Distant CREs are important for transcriptional regulation.

KRT17 modulates the expression of the transcriptional regulator AIRE in diseased epithelia.


Formation of N-terminal pyroglutamate by glutamine cyclase (GC) competes with NTAQ1 for Nt-Gln substrates.

Higher plasma levels of I-carnitine, when associated with trimethylamine N-oxide, are positively correlated with cardiovascular events in humans.

Concentrations of SNV and CNV in stem-cell regulatory elements and binding sites of transcription factors in iPSC-lines are distinct from their founding cells.

Autophagy deficiency in the liver increases vulnerability to insulin resistance.

Ribosome-inactivating protein-2 (RIP-2) interacts with the p75 NTR death domain

Reducing H3k4me3 methylation induces mouse epiblast stem cells to naive pluripotency efficiently.

Intra-cerebroventricular infusion of amyloid-β oligomers reduces expression of fibronectin type-III domain-containing protein 5 mRNA in mice hippocampi.

Oxidative DNA damage inhibits STING signalling.

Roughly 55% of women with chronic pelvic pain have no underlying pathology.

Removal of H3K9me3 by ectopic expression of other H3K9 demethylases improves reprogramming efficiency in SCNT experiments.

Guanine nucleotide dissociation inhibitor (Rho-GDI) interacts with the p75 NTR death domain

Replacement of histone H2A with H2A.Z accelerates gene activation in yeasts by destabilizing +1 nucleosomes.

p75 NTR - associated cell death executor (NADE) interacts with the p75 NTR death domain

The deamination of cytidine to uridine on the minus strand of viral DNA can inactivate the viral genome by inducing G-to-A mutations.

Pyridostatin stabilizes the G - quadruplex in the telomeric region.

JMJD6 slows the hydroxylation of C-terminal lysine

Kir7.1 modulates channel activity by the G protein-coupled melanocortin-4 receptor (MC4R) in the paraventricular nucleus of the hypothalamus.

Emodin forms hydrogen bonds with residues involved in PGAM1 substrate binding.


FoxO3a activation in neuronal death is inhibited by reactive oxygen species (ROS).

Hematopoietic Stem Cell purification reaches purity rates above 90%.

Adult tissue-resident macrophages stem from the embryonal yolk sac and fetal liver.

Polymeal nutrition increases cardiovascular mortality.

Guanine nucleotide exchange factors (GEFs) mediate RhoA activation in response to tensional forces on fibronectin-binding integrins.

Integrating classroom-based collaborative learning with Web-based collaborative learning offers the best class performance.

Mitochondria play a trivial role in calcium homeostasis.

Nigerian physicians constitue the largest component of sub-Saharan Africa-trained physicians in the United States.

Sequence conservation in gene regulatory regions between species is a high-accuracy predictor of conserved functionality.

Recognition of start codons depends on the translation initiation factor IF3.

Replacement of histone H2A with H2A.Z accelerates gene activation in yeasts by destabilizing +1 nucleosomes.

The minor G allele of FOXO3 downregulates pro-inflammatory cytokines.

Foxk2 regulates autophagy genes in muscle cells and fibroblast cells.

The gene daf-16, which encodes forkhead Box O (FOXO), is required for all phenotypes associated with reduced insulin/insulin-like growth factor (Igf) signaling.

Foxp3 represses the expression of transcriptional regulators implicated in memory T cell development.

Foxp3 enables the expression of transcriptional regulators implicated in memory T cell development.

Activated Cdk5 regulates DNA damage-induced neuronal death.

The minor G allele of FOXO3 is related to less severe symptoms of Crohn's Disease.

Forkhead 0 (fox0) transcription factors are involved in apoptosis.


Foxk2 regulates autophagy genes in muscle cells and fibroblast cells.

Sn is present on mature DCs during inflammation in vivo.

CCL19 is predominantly present within dLNs.

TNFAIP3 is a glioblastoma tumor enhancer.

Notch signaling occurs between tumor cells and stromal cells.

Rising temperatures caused by global warming increases risk of dengue fever transmission.

Bariatric surgery reduces colorectal cancer.

Cyclin A2 destruction is necessary to switch from unstable to stable kt-mt attachments in mitosis.

CDK6 shows improved binding to loss-of-function variants of p18 INK4C.

Metastatic colorectal cancer treated with a single agent fluoropyrimidines resulted in similar efficacy and better quality of life when compared with oxaliplatin-based chemotherapy in elderly patients.

The minor G allele of FOXO3 up-regulates IL-10.

Reduced responsiveness to interleukin-2 in regulatory T cells is associated with autoimmune diseases such as Type 1 Diabetes.

Forkhead 0 (fox0) transcription factors are involved in cellular differentiation.

Egr2 regulates the homeostasis of B and T cells.


Foxp3 enables the expression of transcriptional regulators implicated in memory T cell development.

Glycan adaptation involves insertion-deletion events.

BRCA 1 mutation carriers' risk of breast and ovarian cancer depends on where the mutation is located.

Forkhead 0 (fox0) transcription factors are involved in apoptosis.

Thiopurine active metabolites can be catabolized through dephosphorylation of thioguanine nucleotides.

Distant CREs are less conserved among species.

Stiff substrates inhibit mesodermal differentiation by degrading beta-catenin in an integrin-dependent manner.

The TRaF1/C5 rs10818488 allele polymorphism regulates the neighboring C5 gene.

Combination nicotine replacement therapies with varenicline or bupropion are more effective after 12 weeks of reatment compared to varenicline monotherapy.

Active caspase-11 participate in regulating phagosome-lysosome fusion.

A diminished ovarian reserve does not solely indicate infertility in an a priori non-infertile population.

ITAM phosphorylation allows for the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).

CD28 signals regulate trafficking of murine auto-reactive T cells into target tissues.

GATA3 regulates cell cycle progression in bone marrow hematopoietic stem cells.

TNFAIP3 is a glioblastoma tumor suppressor.


Foxp3 represses the expression of transcriptional regulators implicated in memory T cell development.

Aged patients are less susceptible to ischaemia/reperfusion injury.

Sepsis related mortality has remained stable between 2009-2014.

Improvements in OER catalysts show stable activity over several hundred hours.

The ability of activator E2Fs in preventing cell death is limited to terminally differentiated cells.

Recognition of start codons depends on the translation initiation factor IF3.

Inhibiting focal adhesion formation enables cells to convert mechanical strain into eventual scarring.

Mice defective for deoxyribonucleic acid (DNA) polymerase I (polI) fail to reveal increased sensitivity to ionizing radiation (IR).

Increase of p62 in prostate tumor stroma results in defective autophagy.

A T helper 2 cell (Th2) environment impedes disease development in patients with systemic lupus erythematosus (SLE).

FoxO3a activation in neuronal death is inhibited by reactive oxygen species (ROS).

The minor G allele of FOXO3 downregulates pro-inflammatory cytokines.


G-CSF increases the expansion and infiltration of MDSCs into tumors.

IL-10 production by monocytes inhibits CD4 + T cell response.

Early patent ductus ateriosus (PDA) screening decreases in-hospital mortality.

The one-child policy has created a hospitable environment for female infants.

Microcin J25 inhibits nucleoside triphosphate (NTP) binding.

Intra-cerebroventricular infusion of amyloid-β oligomers reduces expression of fibronectin type-III domain-containing protein 5 mRNA in mice hippocampi.

The morphology change from large white adipocytes to small brown adipocytes is a sign of decreased energy expenditure potential in white adipose tissue.

Distant CREs are important for transcriptional regulation.

Glioblastoma multiforme (GBM) is characterized by extensive invasion, rapid growth, necrosis, and angiogenesis.

Ectopic expression of Sall4, Nanog, Esrrb, and Lin28 generates induced pluripotent stem cells from mouse embryonic fibroblasts more efficiently than other factor combinations.

Genomic sequences involved in alternative splicing responsible for Hutchinson-Gilford progeria syndrome (HGPS) are abundant in the ''progerinonly'' allele of Lmna knock-in models.

Cancer-associated fibroblasts (CAFs) interact with cancer cells to mediate formation and activation of CAFs.

Cancer-associated fibroblasts (CAFs) have no known interaction with cancer cells in the formation and activation of CAFs.

Increased vessel density along with a reduction in fibrosis improves the efficacy of chemotherapy treatments.

Osteocytes have an essential role in G-CSF induced HSPC mobilization.

Cancer cells can stimulate the accumulation of intra-tumoural myeloid-derived suppressor cells by promoting granulocyte colony stimulating factor production.


GATA3 regulates cell cycle progression in bone marrow hematopoietic stem cells.

Ca2+ cycling controls whole-body energy homeostasis in beige fat.

Sympathetic nerve activity is reduced throughout normal pregnancy.

Expression of MSX2 is induced 3 hours after the addition of BMP4, which is earlier than T and CDX2.

Mitochondria play a major role in energy production.

Suboptimal nutrition is a leading cause of premature death

Gastric infection with Helicobacter pylori decreases risk of gastric cancer in humans.

In melanoma, anti-CTLA-4 treatment reinvigorates exhausted PD-1+Eomes+CD8 T cells.

In transgenic mice harboring green florescent protein under the control of the Sox2 promoter, more than 50 percent of the cells with green florescent colocalize with cell proliferation markers.

The PDPN gene deactivates the C-type lectin receptor (CLEC-2).

GATA3 regulates self-renewal capacity in bone marrow hematopoietic stem cells.

Egr3 regulates the homeostasis of B and T cells.

Foxp3 enables the expression of transcriptional regulators implicated in memory T cell development.

Foxp3 represses the expression of transcriptional regulators implicated in memory T cell development.

TNFAIP3 is a glioblastoma tumor enhancer.

TNFAIP3 is a tumor enhancer in glioblastoma.

The minor G allele of FOXO3 up-regulates IL-10.

Foxk2 regulates autophagy genes in muscle cells and fibroblast cells.


GATA3 regulates self-renewal capacity in bone marrow hematopoietic stem cells.

Pediatric SCD patients with vaso-occlusive crisis show increased morphine use after breathing 80 ppm iNO for 4 hours.

A diminished ovarian reserve is a very strong indicator of infertility, even in an a priori non-infertile population.

The recruitment of Wdr5 to its target loci depends on Kat8.

Inhibiting glucose-6-phospate dehydrogenase improves lipogenesis by deactivating LKB1-AMPK signaling.

ALDH1 expression is associated with poorer prognosis for breast cancer primary tumors.

Intra-cerebroventricular infusion of amyloid-β oligomers increases expression of fibronectin type-III domain-containing protein 5 mRNA in mice hippocampi.

Patients with common epithelial cancers  are more likely to have an emergency event as their first hospital admission if they live in resource-deprived areas.

Approximately 250,000 people are infected with human T-cell lymphotropic virus type 1 in the United Kingdom.

GATA3 regulates cell cycle progression in bone marrow hematopoietic stem cells.

TNFAIP3 is a glioblastoma tumor suppressor.

IL-10 production by monocytes inhibits CD4 + T cell response.


Gastric infection with Helicobacter pylori decreases risk of gastric cancer in humans.

Intake of folic acid (FA) and vitamin B6 (VB6) reduces levels of homocysteine.

Primary cervical cytology screening with HPV detection has higher longitudinal sensitivity to detect severe cervical intraepithelial neoplasia than conventional cytology.

Amitriptyline is an effective treatment for chronic tension-type headaches.

Anthrax spores remain deadly until affected areas are decontaminated.

Human embryonic stem cells give rise to cell types from the outer embryonic germ layer, but not the other two layers.

The origin of the CRF01_1b2k protein occurred between 1923 and 1956.

Rhythmic expression of Cry1 translates directly into a circadian regulation of cAMP signaling in gluconeogenesis.

HAND2 methylation is a key step in early endometrial carcinogenesis.

Antimicrobial agents are more effective due to the pressure of antimicrobial usage.

Gastric infection with Helicobacter pylori increases risk of gastric cancer in humans.

H.pylori-mediated gastric cancer occurs due to the accumulation of mutations in host epithelial cells.

Ten percent (10%) of kidney cancers in the UK are attributable to excess weight.

The latent infection of myeloid cells with human cytomegalovirus induces a number of changes in gene expression.

Gastric lavage is an effective treatment for acute paraquat poisoning.

Pioglitazone use is significantly associated with an increased risk of pancreatic cancer.

In breast cancer, the loss of myoepithelial cells slows the transition of ductal carcinoma in situ to invasive carcinoma.

In breast cancer, the loss of myoepithelial cells promotes the transition of ductal carcinoma in situ to invasive carcinoma.

High levels of CRP lead to a higher risk of exacerbations in chronic obstructive pulmonary disease (COPD).


Gastric infection with Helicobacter pylori increases risk of gastric cancer in humans.

Differentiated E2f-1, -2, -3 TKO cells in the intestine do not exhibit apoptosis.

NR5A2 does not play a role in development of endometrial tissues.

The risk of breast cancer among parous women decreases with placental weight of pregnancies.

One in two surgical randomized controlled trials are discontinued early.

Formation of N-terminal pyroglutamate by glutamine cyclase (GC) competes with NTAQ1 for Nt-Gln substrates.

The C-type lectin receptor (CLEC-2) rearranges the actin cytoskeleton in dendritic cells to promote efficient motility along stromal surfaces.

Participants who quit smoking reduce lung cancer risk by approximately 50%.

Adult tissue-resident macrophages stem from the embryonal yolk sac and fetal liver.

Converting apoE4 to apoE3 by gene editing worsens the pathology associated with apoE4 in human iPSCderived neurons.

The removal of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells.


Gastric lavage is an effective treatment for acute paraquat poisoning.

Increased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm.

LDL cholesterol has a causal role in the development of cardiovascular disease.

General exercise therapy is more effective than rotator cuff exercises in reducing pain and improving function of the shoulder.

A country's Vaccine Alliance (GAVI) eligibility is not indictivate of accelerated adoption of the Hub vaccine.

Chenodeoxycholic acid treatment decreases brown adipose tissue activity.

BRCA 1 mutation carriers' risk of breast and ovarian cancer depends on where the mutation is located.

Primary pro-inflammatory cytokines suppress secondary pro- and anti-inflammatory mediators.

Specialized functional cell types can be derived from human pluripotent stem cells.

HbA1c consistently overestimates glycemic control in black individuals with Sickle cell trait (SCT).

HAND2 methylation is a key step in early endometrial carcinogenesis.

Charcoal is an effective treatment for acute paraquat poisoning.

Charcoal shows no benefit for acute paraquat poisoning.

The most prevalent adverse events to Semaglutide are gastrointestinal.

Noninvasive positive pressure ventilation is not predictive of acute respiratory failure after solid organ transplantation.

Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission.


General exercise therapy is more effective than rotator cuff exercises in reducing pain and improving function of the shoulder.

1 in 5 million in UK have abnormal PrP positivity.

Measuring routine outcomes is more beneficial to clinical practice than assessing treatment adherence.

Insulin decreases risk of severe kidney failure.

Genes regulated by Esrrb transcription factor are sensitive to Mbd3 function.

The World Health Organization's (WHO) data collection process is biased downward by unequal selection of larger outbreaks.

Trans-acting factors, such as lncRNAs, influence mRNA translation.

Eliminating the last sporadic cases of malaria requires considerable funding.

JMJD6 slows the hydroxylation of C-terminal lysine

Noninvasive positive pressure ventilation is not predictive of acute respiratory failure after solid organ transplantation.

Rotator cuff exercises are more effective than general exercise therapy in reducing pain and improving function of the shoulder.

General exercise therapy is more effective than scapular stabilizer exercises in reducing pain and improving function of the shoulder.

Scapular stabilizer exercises are more effective than general exercise therapy in reducing pain and improving function of the shoulder.

Surgical treatment is not superior to non-surgical in treating adults with displaced fractures of the proximal humerus.

Roughly 55% of women with chronic pelvic pain have no underlying pathology.

There is a positive correlation between hip fractures and statin use.

Amitriptyline is an effective treatment for chronic tension-type headaches.

Diabetes remission occurs less in people treated with conventional therapy than in people treated with laparoscopic adjustable gastric banding surgery.

Diabetes remission occurs more in people treated with conventional therapy than in people treated with laparoscopic adjustable gastric banding surgery.


General exercise therapy is more effective than scapular stabilizer exercises in reducing pain and improving function of the shoulder.

Interleukin-18 plays an important role in the pathogenesis of atherosclerosis.

Polymeal nutrition increases cardiovascular mortality.

The DEXI promoter region is bound by multiple transcription factors in a murine haematopoietic progenitor cell line.

Clathrin stabilizes the spindle fiber apparatus during mitosis.

Upregulation of dynein in Drosophila neurons increases the number of microtubule plus-ends growing toward the cell body of each neuron.

Decreased conversion of PGE 2 to PPARy ligand 15-ket-PGE 2 causes accumulation of PGE.

Incidence of 10/66 dementia is lower than the incidence of DSM-IV dementia.

Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 inhibit West Nile virus replication in cortical neurons.

The G34R/V mutation does not create a hypomethylated phenotype at the H3K36 histone.

Sepsis related mortality has remained stable between 2009-2014.

Medications to treat obesity do not have side effects.

Antidepressants reduce the severity of migraines.


Genes involved in pre-mRNA splicing have a significant impact on genome stability.

Human embryonic stem cells give rise to cell types from all three embryonic germ layers.

The cytokine receptor which regulates chemotaxis and formation of lymph nodes is involved in production of myeloperoxidase in the left atrium.

NR5A2 is important in reverse cholesterol transport in humans.

Cellular clocks are not predictive of mitosis timing in NIH 3T3 cells.

CHOP is a general endoplasmic reticulum stress marker.

FoxO3a activation in neuronal death is inhibited by reactive oxygen species (ROS).

PGE 2 suppresss intestinal tumor growth by altering the expression of tumor suppressing and DNA repair genes.

Oxidative DNA damage inhibits STING signalling.

Stiff substrates inhibit mesodermal differentiation by degrading beta-catenin in an integrin-dependent manner.

Acute ablation of Snail in the embryonic cortex affects the proliferation and number of embryonic cortical precursors.

Pre-mRNAs associated with spliceosomal components are more stable than unassociated splicing substrates.

Pre-mRNAs associated with spliceosomal components are less stable than unassociated splicing substrates.

Trans-acting factors, such as lncRNAs, influence mRNA translation.

miRNAs regulate a unique suite of mRNAs to maintain homeostasis in cells.

Understanding epigenetic regulation of replication is essential for the reational design of episomally replicating vectors.

Long - range chromatin interactions regulate transcription.

Cellular differentiation of embryonic stem cells is accompanied by changes in replication timing, transcription and nuclear localization.

Pseudoknots are not evolutionarily conserved in most eukaryotes.

Sequence conservation in gene regulatory regions between species is a high-accuracy predictor of conserved functionality.


Genes regulated by Esrrb transcription factor are sensitive to Mbd3 function.

Formation of N-terminal pyroglutamate by glutamine cyclase (GC) competes with NTAQ1 for Nt-Gln substrates.

Suboptimal nutrition is a leading cause of premature death

Increased flux of microbial products suppresses immune responses.

70% of burn patients are admitted for hospitalization and further treatment after appearing at hospital emergency wards or outpatient clinics.

The density of cytokine receptor bearing cells has no effect on the distance over which cytokines act.

Nuclear transfer from adult human fibroblasts to human oocytes can give rise to blastocysts containing expandable pluripotent cells.

The innate immune response struggles to remove small numbers of parasites.

Individuals with Alzheimers who participate in six months of physical activity improve cognitive function for up to 18 months.

CCL19 is predominantly present within dLNs.

Bariatric surgery leads to positive outcomes in mental health.

MUC1-C activates the NF-κB p65 signaling pathway by interacting with IκB kinase ß.

KRT17 modulates the expression of the transcriptional regulator AIRE in diseased epithelia.

The PPR MDA5 has twenty N-terminal CARD domains.

The DEXI promoter region is bound by multiple transcription factors in a murine haematopoietic progenitor cell line.

JMJD6 catalyzes the hydroxylation of C-terminal lysine and supresses transcriptional activity.

TNFAIP3 is a glioblastoma tumor suppressor.

Foxp3 enables the expression of transcriptional regulators implicated in memory T cell development.

Mutations in RIM1 raise levels of IME1 RNA.

Mutations in RIM1 decrease levels of IME1 RNA.


Genetic deficiency of mast cells leads to decreased weight gain in a mouse model of diet-induced obesity.

There is a positive correlation between hip fractures and statin use.

Increased conversion of PGE 2 to PPARy ligand 15-ket-PGE 2 causes accumulation of PGE.

Alirocumab treatment reduces apo(a) fractional clearance rate.

Treatment with a protein named FN restores regenerative abilities of aged muscles.

Dscam1 acts as a hypervariable pattern-recognition receptor for the immune system.

eRNAs influence is linked to senescence, aging, and carcinogenesis.

Replacement of OCT4 and SOX2 genes with GATA3 has the ability to reprogram human cells.

PRC1-bound plasmids sediment at a slower rate in unbound plasmids than in sucrose gradients.

Forkhead 0 (fox0) transcription factors are involved in apoptosis.

Inhibiting focal adhesion formation increases the rate at which cells convert mechanical strain into inflammation and fibrosis.

Excess gestational weight gain is associated with obesity-related pregnancy outcomes.

Ten percent (10%) of kidney cancers in the UK are attributable to excess weight.

Women with a lower birth weight are more likely to develop breast cancer later in life.

Birth-weight is negatively associated with breast cancer.

Autophagy deficiency in the liver increases vulnerability to insulin resistance.

Medications to treat obesity do not have side effects.

Medications to treat obesity have unwanted side effects.

IL-10 production by monocytes inhibits CD4 + T cell response.

Exercise increases cancer mortality rates among Chinese citizens.


Genetic deletion of JAM-A increases gut permeability.

Reduction of Rpl38 alters the composition of the Hox gene mRNAs translation in mice without lowering overall protein synthesis.

H.pylori-mediated gastric cancer occurs due to the accumulation of mutations in host epithelial cells.

IL-6 signaling plays a major role in atherosclerotic cardiovascular disease.

Antimicrobial agents are more effective due to the pressure of antimicrobial usage.

Intra-cerebroventricular infusion of amyloid-β oligomers reduces expression of fibronectin type-III domain-containing protein 5 mRNA in mice hippocampi.

Increased lipolysis leads to higher P38 phosphorylation in adipose tissue.

Ethanol stress increases the expression of SRL in bacteria.

Emodin forms hydrogen bonds with residues involved in PGAM1 substrate binding.

Overexpressing Cnp1 N-tail variants rescues the temperature-sensitive growth defect of scm3-139.

The minor G allele of FOXO3 downregulates pro-inflammatory cytokines.

Alirocumab treatment reduces apo(a) fractional clearance rate.

Glycan adaptation involves insertion-deletion events.

Exhaustion of B cells contributes to poor Ab response in HIV-infected individuals.

Increased flux of microbial products provokes immune responses.

Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection increases dissemination of Salmonella Typhimurium from the gut.

Acute ablation of Snail in the embryonic cortex affects the proliferation and number of embryonic cortical precursors.

Cytochrome c is transferred from cytosol to the mitochondrial intermembrane space during apoptosis.


Genomic aberrations of metastases provide information for targeted therapy.

Cellular differentiation of embryonic stem cells is accompanied by changes in replication timing, transcription and nuclear localization.

Folate and vitamin B12 levels influence the association between homocysteine and preeclampsia.

Ribosome-inactivating protein-2 (RIP-2) interacts with the p75 NTR death domain

The combination of physical examinations with C-reactive protein values do not improve the accuracy of radiographic verified pneumonia predictions.

In transgenic mice harboring green florescent protein under the control of the Sox2 promoter, more than 50 percent of the cells with green florescent colocalize with cell proliferation markers.

The H2A-H2B eviction defect is compensated for by other histone chaperone(s).

Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes epithelial damage.

The mean suicide rate in women is higher after miscarriage than live birth.

LSD1-positive promoters are associated with RNA polymerase II

Monoclonal antibody targeting of N-cadherin encourages metastasis.

Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission.

Nonsteroidal antinflammatory drugs show potential anticancer indications.

Repressing IL-18 has negative effects on atherosclerotic lesion composition and progression.

Systemic immunosuppressive (IS) therapy increases the chance of cancer mortality in patients with inflammatory eye disease (IED)

Deletion of ATM and Rad3 related protein is not predictive of acute tissue loss.

Incidence of 10/66 dementia is lower than the incidence of DSM-IV dementia.

Systemic immunosuppressive (IS) therapy does not enhance the chance of cancer mortality in patients with inflammatory eye disease (IED)

Incidence of 10/66 dementia is higher than the incidence of DSM-IV dementia.


Genomic sequences involved in alternative splicing responsible for Hutchinson-Gilford progeria syndrome (HGPS) are abundant in the ''progerinonly'' allele of Lmna knock-in models.

Activated Cdk5 phosphorylates the ATM protein in response to DNA damage.

Ly6C hi monocytes have a higher inflammatory capacity than Ly6C lo monocytes.

There is no association between HNF4A mutations and diabetes risks.

4-PBA treatment decreases endoplasmic reticulum stress in response to general endoplasmic reticulum stress markers.

TRAP+ osteoclasts regulate mature osteoblast maintenance.

Nonhypertensive people who are 55 years old have a 90% chance of developing hypertension during their lifetime.

Rotator cuff exercises are more effective than general exercise therapy in reducing pain and improving function of the shoulder.

Distant CREs are less conserved among species.

Lmna knock-in models are appropriate for testing therapeutic approaches against Hutchinson-Gilford progeria syndrome (HGPS).

A single nucleotide variant the gene DGKK is strongly associated with increased risk of hypospadias.

A strong bias in the phage genome locations where the spacers were derived has been observed in many CRISPR subtypes that confer the immunity to phage.

Increased mobility of retrotransposons is assosciated with mutation and higher tumorigenesis rates.

Increased mobility of retrotransposons does not lead to mutation and higher tumorigenesis rates.

Pre-mRNAs associated with spliceosomal components are less stable than unassociated splicing substrates.

Genes involved in pre-mRNA splicing have a significant impact on genome stability.

Pre-mRNAs associated with spliceosomal components are more stable than unassociated splicing substrates.

Reduction of Rpl38 alters the composition of the Hox gene mRNAs translation in mice without lowering overall protein synthesis.


90% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.

Hypocretin neurones suppress panicprone state in rats.

Mice lacking Sirt1 in Sf1-expressing neurons are immune to diet-induced obesity and insulin resistance.

Alteration of origin firing causes changes in termination zones of Okazaki fragments.

61% of colorectal cancer patients are diagnosed with regional or distant metastases.

Participants who quit smoking reduce lung cancer risk by approximately 50%.

Egr3 regulates the homeostasis of B and T cells.

Human embryonic stem cells have the capacity to give rise to differentiated progeny representative of all three embryonic germ layers.

Rhythmic expression of Cry1 translates directly into a circadian regulation of cAMP signaling in gluconeogenesis.

Treatment with a protein named FN impairs regenerative abilities of aged muscles.

Headaches are correlated with cognitive impairment.

Hypothalamic glutamate neurotransmission is unrelated to energy balance.

Energy balance requires hypothalamic glutamate neurotransmission.

Occipital activation levels are associated with auditory spatial performance in parietal regions of the brain.

Insulin effects appetite via ventral tegmental neurons.

Migraine with aura is associated with ischemic stroke.

Myelin sheaths play a role in action potential propagation.

Patients with panic anxiety show decreased CSF levels of hypocretin.

Sudden death can occur in patients with orthostatic hypertension without cardiac conduction abnormalities.


Glioblastoma multiforme (GBM) is characterized by extensive invasion, rapid growth, necrosis, and angiogenesis.

APOE4 expression in iPSC-derived neurons results in decreased tau phosphorylation.

ART substantially reduces infectiveness of HIV-positive people.

Mutations in RIM1 raise levels of IME1 RNA.

Satellite cell dysfunction is a key factor in sarcopenia development.

Bariatric surgery reduces postmenopausal breast cancer.

Lack of FGF21 in mice leads to reduced lifespan.

T cell receptor /CD3 microdomains are required to induce the immunologic synapse.

Algerian physicians constitue the largest component of sub-Saharan Africa-trained physicians in the United States.

Upon viral challenge, influenza-specific memory CD4+ T cells greatly enhance the early production of inflammatory chemokines in the lung.

Decreased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm.

Cancer-associated fibroblasts (CAFs) are constituents of tumor microenvironments

Cancer-associated fibroblasts (CAFs) have no known interaction with cancer cells in the formation and activation of CAFs.

Cancer-associated fibroblasts (CAFs) interact with cancer cells to mediate formation and activation of CAFs.

Cancer cells can stimulate the accumulation of intra-tumoural myeloid-derived suppressor cells by promoting granulocyte colony stimulating factor production.

Microglia are an innate immune cell type of the central nervous system.

Tuberculosis-induced granulomas express different immune system protein signatures than the surrounding tissue.

Fibroblast Growth Factor is a ligand which signals through receptor tyrosine kinases.

Mutations in G-Beta protein GNB1 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.

G-CSF increases the expansion and infiltration of MDSCs into tumors.


Glucose restriction to 0.05% reduces RLS (replicative life span) by 20-40% in S. cerevisiae.

CD44v6 is not associated with constitutive and reprogrammed cancer stem cells driving cancer metastasis.

The ability of activator E2Fs in preventing cell death is limited to terminally differentiated cells.

The morphology change from large white adipocytes to small brown adipocytes is a sign of decreased energy expenditure potential in white adipose tissue.

Vitamin D is an important factor in the relationship between calcium and parathyroid hormone.

Taxation of sugar-sweetened beverages reduced the incidence rate of type II diabetes in India.

Chemical injury represses transglutaminase 2 activity.

G-CSF increases the expansion and infiltration of MDSCs into tumors.

Urbanization is an important risk factor related to the transmission of dengue fever.

Expression of MSX2 is induced 3 hours after the addition of BMP4, which is earlier than T and CDX2.

H4 G94P proteins suppress degradation of free histones via Rad53-dependent mechanisms.

Ethanol stress reduces the expression of SRL in bacteria.

Transcription rates in S. cerevisiae range between 0.7 and 2 kb/min.

Transcription rates in S. cerevisiae range between 7 and 12 kb/min.

Ethanol stress increases the expression of SRL in bacteria.

The Snf1 complex regulates carbon and energy metabolism in baker's yeast (Saccharomyces cerevisiae).

Ethanol stress lowers the expression of PSP in bacteria.

Healthy volunteers exhibit rapid and transient increase of cellular ATP after being bolus-injected with fructose.

Ethanol stress increases the expression of PSP in bacteria.

Ethanol stress increases the expression of IBP in bacteria.


Glycan adaptation involves insertion-deletion events.

Mice are incapable of producing neutralizing antibodies in reponse to the Chikungunya virus (CHIKV) produced in mosquitos.

Removal of H3K9me3 improves reprogramming efficiency in human somatic cell nuclear transfer experiments.

Bariatric surgery reduces colorectal cancer.

Female carriers of the Apolipoprotein E4 (APOE4) allele have shorter lifetime exposure to estrogen due to a decreased reproductive period.

Intra-cerebroventricular infusion of amyloid-β oligomers reduces expression of fibronectin type-III domain-containing protein 5 mRNA in mice hippocampi.

Rapamycin increases the concentration of triacylglycerols in fruit flies.

90% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.

Monoclonal antibody targeting of N-cadherin encourages castration resistance.

A strong bias in the phage genome locations where the spacers were derived has been observed in many CRISPR subtypes that confer the immunity to phage.

Ethanol stress reduces the expression of SRL in bacteria.

The deamination of cytidine to uridine on the minus strand of viral DNA can inactivate the viral genome by inducing G-to-A mutations.

Glycan adaptation is rarely observed in the B-cell repertoire.

The latent infection of myeloid cells with human cytomegalovirus induces a number of changes in gene expression.

Monoclonal antibody targeting of N-cadherin encourages metastasis.

Monoclonal antibody targeting of N-cadherin inhibits growth.

Recognition of start codons depends on the translation initiation factor IF3.

Trans-acting factors, such as lncRNAs, influence mRNA translation.


Glycan adaptation is rarely observed in the B-cell repertoire.

7-day-old adult Caenorhabditis elegans exhibit approximately 75% of the learning capacity seen in 1-day old adults.

The C-type lectin receptor (CLEC-2) rearranges the actin cytoskeleton in dendritic cells to promote efficient motility along stromal surfaces.

Broadly HIV-1 Neutralizing Antibodies (bnAb) 10EB have no affinity for phospholipids.

Deregulation of HAND2 is a crucial step in endometrial carcinogenesis in mice.

Normal expression of RUNX1 causes tumorsupressing effects.

Neutrophils produce IL-1β in response to large particles.

Chlamydia trachomatis is most prevalent in the UK among individuals in their 50s and 60s.

Physical activity level has no association with the difference in maximal oxygen consumption between black and white youth.

Lack of FGF21 in mice leads to reduced lifespan.

Chronic HIV stimulation of B cells leads to the premature exhaustion of B cells.

Varying expression levels of EBI2 affect the positioning and migration of B cells.

Exhaustion of B cells contributes to poor Ab response in HIV-infected individuals.

The innate immune response struggles to remove small numbers of parasites.

B cells go though plasmablast differentiation and antibody production by continuous expression of EBI2.


Gpr124 increases BBB breakdown in mouse models of ischemic stroke.

Measuring routine outcomes is more beneficial to clinical practice than assessing treatment adherence.

A deficiency of folate increases blood levels of homocysteine.

LDL cholesterol has a causal role in the development of cardiovascular disease.

Removal of H3K9me3 by ectopic expression of other H3K9 demethylases improves reprogramming efficiency in SCNT experiments.

Forkhead 0 (fox0) transcription factors are involved in cellular differentiation.

Bariatric surgery leads to positive outcomes in mental health.

Normal granulomas form in the presence of TNF in Zebrafish.

Expression of oncolytic virus antigens as peptides makes relapse more likely.

Homozygous deletion of murine Sbds gene from osterix-expressing mesenchymal stem and progenitor cells (MPCs) induces oxidative stress.

Gpr124 suppresses BBB breakdown in mouse models of ischemic stroke.

Activated Cdk5 phosphorylates the ATM protein in response to DNA damage.

Mice without IFN-γ or its receptor are highly susceptible to EAM induced with α-MyHC/CFA.

Antiretroviral therapy increases rates of tuberculosis across a broad range of CD4 strata.

p16INK4A degradation is encoded by CDKN2A.

Toll-like receptor (TLR) signaling is involved in the pathogenesis of human MDS.

A mutation in HNF4A leads to an increased risk of developing diabetes by the age of 14 years.

Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes fibrosis.

A mutation in HNF4A leads to an increased risk of diabetes by the age of 14 years.


Gpr124 suppresses BBB breakdown in mouse models of ischemic stroke.

Long - range chromatin interactions regulate transcription.

Oxidative DNA damage inhibits STING signalling.

Expression of oncolytic virus antigens as peptides permits additional protection against relapse.

Acute ablation of Snail in the embryonic cortex affects the proliferation and number of embryonic cortical precursors.

Basophils promote disease development in patients with systemic lupus erythematosus (SLE).

BiP is a general endoplasmic reticulum stress marker.

Tuberculosis incidence occurs at higher rates in more sparsely populated areas in the UK.

Pseudogene PTENP1 encodes a transcript that regulates PTEN expression.

Sudden death can occur in patients with orthostatic hypertension without cardiac conduction abnormalities.

Beta-band coherence is diminished for visible stimuli over invisible stimuli.

RAD52 is involved in break-induced DNA replication (BIR).

Mice that lack Interferon-γ or its receptor are highly susceptible to experimental autoimmune myocarditis.

The DdrB protein from Deinococcus radiodurans functions as a pentamer.


Guanine nucleotide dissociation inhibitor (Rho-GDI) interacts with the p75 NTR death domain

Weighed food records (WFR) result in high completion since they're cheap to run and impose low participant burden.

Ly49Q directs the organization of neutrophil polarization by regulating membrane raft functions.

MICAL redox enzymes regulate actin dynamics in many cell types.

Risedronate increases risk of vertebral and non-vertebral fractures.

Diabetes remission occurs less in people treated with conventional therapy than in people treated with laparoscopic adjustable gastric banding surgery.

Albendazole is used to treat soil-transmitted helminths.

Glucose restriction to 0.05% reduces RLS (replicative life span) by 20-40% in S. cerevisiae.

Patients with common epithelial cancers are less likely to have an emergency event as their first hospital admission if they live in resource-deprived areas.

Birth-weight is negatively associated with breast cancer.

Ribosome-inactivating protein-2 (RIP-2) interacts with the p75 NTR death domain

p75 NTR - associated cell death executor (NADE) interacts with the p75 NTR death domain

Formation of N-terminal pyroglutamate by glutamine cyclase (GC) competes with NTAQ1 for Nt-Gln substrates.

Guanine nucleotide exchange factors (GEFs) mediate RhoA activation in response to tensional forces on fibronectin-binding integrins.

MUC1-C activates the NF-κB p65 signaling pathway by interacting with IκB kinase ß.

Mutations in G-Beta protein GNB1 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.

Replacement of histone H2A with H2A.Z accelerates gene activation in yeasts by destabilizing +1 nucleosomes.

Lysine histone demethylase inhibitor JIB 04 is inactive against KDM5A.


Guanine nucleotide exchange factors (GEFs) mediate RhoA activation in response to tensional forces on fibronectin-binding integrins.

The latent infection of myeloid cells with human cytomegalovirus induces a number of changes in gene expression.

Two variants of chromosome 6q21 are associated with radiation therapy-induced second malignancies in pediatric Hodgkin lymphoma patients.

A high microerythrocyte count protects against severe anemia in homozygous alpha (+)- thalassemia trait subjects.

Integrated care is successful at tackling multiple comorbidities.

Tumor development occurs in conjunction with upregulation of pro-inflammatory cytokines.

Induced hepatic stem cells possess the potential to differentiate into cholangiocytic cells.

Persistor cells are one reason for incomplete responses to Tyrosine kinase inhibitor (TKI) therapy in cancer patients.

Low nucleosome occupancy correlates with high methylation levels across species.

Foxp3 enables the expression of transcriptional regulators implicated in memory T cell development.

Kir7.1 modulates channel activity by the G protein-coupled melanocortin-4 receptor (MC4R) in the paraventricular nucleus of the hypothalamus.

The C-type lectin receptor (CLEC-2) rearranges the actin cytoskeleton in dendritic cells to promote efficient motility along stromal surfaces.

Upregulation of dynein in Drosophila neurons increases the number of microtubule plus-ends growing toward the cell body of each neuron.

Pyridostatin stabilizes the G - quadruplex in the telomeric region.

MICAL redox enzymes regulate actin dynamics in many cell types.

Ly49Q directs the organization of neutrophil polarization by regulating membrane raft functions.

Intra-cerebroventricular infusion of amyloid-β oligomers increases expression of fibronectin type-III domain-containing protein 5 mRNA in mice hippocampi.


H.pylori-mediated gastric cancer occurs due to the accumulation of mutations in host epithelial cells.

The recruitment of Wdr5 to its target loci depends on Kat8.

Oxidative DNA damage activates STING signalling.

Upregulation of PD1 causes the upregulation of Satb1.

Crossover hot spots are found within gene promoters in Saccharomyces cerevisiae.

The risk of cancer rises with level of alcohol consumption.

Osteocytes have an essential role in G-CSF induced HSPC mobilization.

Mitochondria play a trivial role in calcium homeostasis.

Incidence of heart failure increased by 10% in women since 1979.

Suboptimal nutrition is a leading cause of premature death

Major vault protein (MVP) leads to more aggressive tumors by regulating the sorting of tumor suppressive miR-193a into extracellular vesicles (EVs).

Gastric infection with Helicobacter pylori increases risk of gastric cancer in humans.

Gastric infection with Helicobacter pylori decreases risk of gastric cancer in humans.

In breast cancer, the loss of myoepithelial cells slows the transition of ductal carcinoma in situ to invasive carcinoma.

In breast cancer, the loss of myoepithelial cells promotes the transition of ductal carcinoma in situ to invasive carcinoma.

Many cytokines that are produced by cancer cells also contribute to carcinogenesis.

Depletion of nitric oxide is responsible for vasospasm.

The latent infection of myeloid cells with human cytomegalovirus induces a number of changes in gene expression.

Cancer-associated fibroblasts (CAFs) have no known interaction with cancer cells in the formation and activation of CAFs.

Cancer-associated fibroblasts (CAFs) interact with cancer cells to mediate formation and activation of CAFs.


H4 G94P proteins induce chromatin assembly, which increases free histones.

Propriospinal interneurons that play a role in the plastic reorganization of spinal circuits are integral for recovery from spinal cord injury.

Bacteriophagaes MS2 and Qβ are members of the Leviviridae.

Inhibiting focal adhesion formation increases the rate at which cells convert mechanical strain into inflammation and fibrosis.

FACT and other histone chaperone(s) compensate for Histone 2A (H2A)-histone 2B (H2B) dimer eviction during the histone exchange process.

Transplanted human glial progenitor cells can mature in their host animal.

p16INK4A degradation is  linked to an abnormal wound response caused by the microinvasive step of advanced Oral Potentially Malignant Lesions (OPMLs).

1 in 5 million in UK have abnormal PrP positivity.

Measuring routine outcomes is more beneficial to clinical practice than assessing treatment adherence.

Venules have less significant tunica adventitia than arterioles.

H4 G94P proteins inhibit chromatin assembly, which decreases free histones.

H4 G94P proteins induce degradation of free histones via Rad53-dependent mechanisms.

H4 G94P proteins suppress degradation of free histones via Rad53-dependent mechanisms.

The G34R/V mutation does not create a hypomethylated phenotype at the H3K36 histone.

The G34R/V mutation creates a hypomethylated phenotype at the H3K36 histone.

Replacement of histone H2A with H2A.Z accelerates gene activation in yeasts by destabilizing +1 nucleosomes.

The H2A-H2B eviction defect is compensated for by other histone chaperone(s).

Removal of H3K9me3 by ectopic expression of other H3K9 demethylases improves reprogramming efficiency in SCNT experiments.


H4 G94P proteins induce degradation of free histones via Rad53-dependent mechanisms.

Bariatric surgery reduces colorectal cancer.

Patients in stable partnerships have a slower progression from HIV to AIDS.

Intra-cerebroventricular infusion of amyloid-β oligomers increases expression of fibronectin type-III domain-containing protein 5 mRNA in mice hippocampi.

Low nucleosome occupancy correlates with high methylation levels across species.

Genes regulated by Esrrb transcription factor are sensitive to Mbd3 function.

PGE 2 suppresss intestinal tumor growth by altering the expression of tumor suppressing and DNA repair genes.

Environmental factors can influence the development of breast cancer.

De novo assembly of sequence data has fewer specific contigs than unassembled sequence data.

Suboptimal nutrition is a leading cause of premature death

Varying expression levels of EBI2 affect the positioning and migration of B cells.

Removal of H3K9me3 by ectopic expression of other H3K9 demethylases decreases reprogramming efficiency in SCNT experiments.


H4 G94P proteins inhibit chromatin assembly, which decreases free histones.

Varying expression levels of EBI2 affect the positioning and migration of B cells.

Alteration of origin firing causes changes in termination zones of Okazaki fragments.

Neutrophil extracellular trap (NET) antigens may contain the targeted autoantigens PR3 and MPO.

The mean suicide rate in women is higher after miscarriage than live birth.

CCL19 is predominantly present within dLNs.

Type 1 Diabetes is associated with subtle perturbations in T reg development.

The minor G allele of FOXO3 downregulates pro-inflammatory cytokines.

Removal of H3K9me3 improves reprogramming efficiency in human somatic cell nuclear transfer experiments.

L3MBTL2 binds to H2AK119Ub marked chromatin to form a PRC1 complex.


H4 G94P proteins suppress degradation of free histones via Rad53-dependent mechanisms.

A T helper 2 cell (Th2) environment impedes disease development in patients with systemic lupus erythematosus (SLE).

ART substantially reduces infectiveness of HIV-positive people.

Diabetes remission occurs less in people treated with conventional therapy than in people treated with laparoscopic adjustable gastric banding surgery.

RANK-RANKL pathway signalling is linked to development of Aire-expressing medullary thymic epithelial cells.

Replacement of OCT4 and SOX2 genes with GATA3 is not capable of reprogramming human cells.

Physical activity level has no association with the difference in maximal oxygen consumption between black and white youth.

Differentiated E2f-1, -2, -3 TKO cells in the intestine do not exhibit apoptosis.

7-day-old adult Caenorhabditis elegans exhibit approximately 5% of the learning capacity seen in 1-day old adults.

Lipopolysaccharides have an inflammation independent effect on kidney barrier function.


HAND2 methylation is a key step in early endometrial carcinogenesis.

DUSP4 downregulation deactivates the Ras-ERK pathway

British male students are bullied more than British female students.

British female students are bullied more than British male students.

Upregulation of PD1 causes the upregulation of Satb1.

In rhesus macaques, daily subcutaneous injections of emtricitabine are ineffective at protecting against rectally transmitted simian-human immunodeficiency virus.

Ethanol stress lowers the expression of PSP in bacteria.

Ethanol stress increases the expression of PSP in bacteria.

Students who perform poorly in the early years of medical school are at increased risk for professional misconduct later in their careers.

Microcin J25 encourages nucleoside triphosphate (NTP) binding.

Eilat virus (EILV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in nonhuman primates.

Deregulation of HAND2 is a crucial step in endometrial carcinogenesis in mice.

NR5A2 does not play a role in development of endometrial tissues.

Many cytokines that are produced by cancer cells also contribute to carcinogenesis.

Decrease of p62 in prostate tumor stroma results in defective autophagy.

Increase of p62 in prostate tumor stroma results in defective autophagy.

PGE 2 suppresss intestinal tumor growth by altering the expression of tumor suppressing and DNA repair genes.

EGR2 is important to myelination of the peripheral nervous system.

eRNAs influence is linked to senescence, aging, and carcinogenesis.

Foxk2 regulates autophagy genes in muscle cells and fibroblast cells.


HIV trans-activator protein (TAT) effectively transports large and small molecules across cellular membranes into larger populations of neurons.

Oxidative phosphorylation is one of the primary glycometabolic pathways in cells.

The NF-κB essential modulator gene induces intestinal inflammation by promoting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death.

50% of patients exposed to radiation have activated markers of mesenchymal stem cells.

The generation of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells.

G-CSF increases the expansion and infiltration of MDSCs into tumors.

The RANK-RANK-Ligand (RANKL) pathway is involved in the development of Aire-expressing medullary thymic epithelial cells (mTECs).

The tissue surrounding the granuloma in an immune cell induces an anti-inflammatory immune response.

Klf2 is important for proper myeloid cell function.

CDK6 shows improved binding to loss-of-function variants of p18 INK4C.

Lmna knock-in models are appropriate for testing therapeutic approaches against Hutchinson-Gilford progeria syndrome (HGPS).

Mice lacking Sirt1 in Sf1-expressing neurons are immune to diet-induced obesity and insulin resistance.

CD28 signals regulate trafficking of murine auto-reactive T cells into target tissues.

Mice lacking Sirt1 in Sf1-expressing neurons have increased susceptibility to diet-induced obesity and insulin resistance.

Major antigen-induced signals from the T cell receptor and secondary signals from costimulatory receptors are required for T cell activation.

MeCP2 influences the synaptic maturation of neurons.

Many transmembrane receptors transmit signals by long-range conformational changes in the association of alpha-helices across the plasma membrane.

Upregulation of dynein in Drosophila neurons increases the number of microtubule plus-ends growing toward the cell body of each neuron.

Microglia are an innate immune cell type of the central nervous system.


HNF4A mutations are associated with macrosomia in infancy.

Bacterial meningitis can be diagnosed on the basis of positive cerebrospinal fluid (CSF) cultures.

Weighed food records (WFR) result in poor completion since they're costly to run and impose high participant burden.

miRNAs enforce homeostasis by suppressing low-level ''leaky'' transcription.

TNFAIP3 is a glioblastoma tumor suppressor.

V-9302 inhibits antitumor responses by decreasing cell death and oxidative stress.

Destination container port throughput(CPT) is negatively related to dengue virus (DENV-1) diffusion in air traffic shipments.

Differentiation of progenitor cells to myeloid cells is skewed when insulin signaling is suppressed.

Sepsis related mortality has risen from 2009 to 2014.

The DEXI promoter region is bound by multiple transcription factors in a murine haematopoietic progenitor cell line.

90% of patients with melanoma and an objective response to PD-1 blockade will experience a progression in their melanoma.

Carriers of HNF4A mutations are at reduced risk for diabetes.

A mutation in HNF4A leads to an increased risk of developing diabetes by the age of 14 years.

A mutation in HNF4A leads to an increased risk of diabetes by the age of 14 years.

There is no association between HNF4A mutations and diabetes risks.

A deficiency of vitamin B12 decreases blood levels of homocysteine.

The G34R/V mutation creates a hypomethylated phenotype at the H3K36 histone.

Mutations in G-Beta protein GNB1 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.

The G34R/V mutation does not create a hypomethylated phenotype at the H3K36 histone.

The generation of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells.


HOXB4 facilitates HSC expansion when co-cultured with HSCs.

Cost effectiveness evaluations based on cRCT data lack external validity.

Incidence of sepsis has fallen substantially from 2009 to 2014.

Repressing IL-18 has negative effects on atherosclerotic lesion composition and progression.

Inhibiting HDAC6 increases survival of mice with ARID1A mutated tumors.

Physical activity level is associated with the difference in maximal oxygen consumption between black and white youth.

Continued HHV-8 transmission among MSM in San Francisco may be explained by urogenital contact.

Early patent ductus ateriosus (PDA) screening increases in-hospital mortality.

The minor G allele of FOXO3 is related to less severe symptoms of Crohn's Disease.

Formation of N-terminal pyroglutamate by glutamine cyclase (GC) competes with NTAQ1 for Nt-Gln substrates.

HOXB4 is a highly expressed component of cellular secretome from fetal liver cell populations.

Osteocytes have an essential role in G-CSF induced HSPC mobilization.

Klf4 is important for proper myeloid cell differentiation.

Induced hepatic stem cells possess the potential to differentiate into cholangiocytic cells.

Klf4 is not required for proper myeloid cell differentiation.

Reduced phosphorylation of PP2A increases HDAC4 dephosphorylation by enhancing PP2A-HDAC4 interaction.

GATA3 regulates self-renewal capacity in bone marrow hematopoietic stem cells.

G-CSF increases the expansion and infiltration of MDSCs into tumors.


HOXB4 is a highly expressed component of cellular secretome from fetal liver cell populations.

Weighed food records (WFR) result in high completion since they're cheap to run and impose low participant burden.

Emodin forms hydrogen bonds with residues involved in PGAM1 substrate binding.

HNF4A mutations are associated with macrosomia in infancy.

Genetic deletion of JAM-A increases gut permeability.

Ly6C hi monocytes have a higher inflammatory capacity than Ly6C lo monocytes.

Adult tissue-resident macrophages stem from the embryonal yolk sac and fetal liver.

RAD52 is involved in break-induced DNA replication (BIR).

Active Ly49Q induces neutrophil polarization.

Varenicline monotherapy is more effective after 26 weeks of treatment compared to combination nicotine replacement therapies with varenicline or bupropion.

Klf2 is important for proper myeloid cell function.

Bone marrow cells don't contribute to adult macrophage compartments.

GATA3 regulates cell cycle progression in bone marrow hematopoietic stem cells.

Foxk2 regulates autophagy genes in muscle cells and fibroblast cells.


HSCT-T dosage may not be diagnostic if the onset of symptoms occurs less than 3 hours before AMI.

The World Health Organization's (WHO) data collection process is biased downward by unequal selection of larger outbreaks.

Noninvasive positive pressure ventilation is not predictive of acute respiratory failure after solid organ transplantation.

The proliferative capacity of progenitors is regulated cell-autonomously.

A mutation in HNF4A leads to an increased risk of diabetes by the age of 14 years.

ERAP1 SNPs are epistatic to HLA alleles for ankylosing spondylitis.

Chemical injury represses transglutaminase 2 activity.

4-PBA treatment decreases endoplasmic reticulum stress in response to general endoplasmic reticulum stress markers.

Differentiation of progenitor cells to myeloid cells is skewed when insulin signaling is suppressed.

Increase of p62 in prostate tumor stroma results in defective autophagy.

Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes fibrosis.

Amitriptyline is an effective treatment for chronic tension-type headaches.

Toll-like receptor (TLR) signaling is involved in the pathogenesis of human MDS.

CD28 initiates tonic signaling in conventional T cells, which causes an exhaustion phenotype and limited efficiency.

In melanoma, anti-CTLA-4 treatment reinvigorates exhausted PD-1+Eomes+CD8 T cells.

Including pharmacists in rounding teams does not alter the incidence of adverse drug events (ADEs).

The most prevalent adverse events to Semaglutide are cardiovascular.

Type 1 Diabetes is associated with subtle perturbations in T reg development.

Major antigen-induced signals from the T cell receptor and secondary signals from costimulatory receptors are required for T cell activation.

Certain immunomodulator-human dialyzable leukocyte extract (hDLE) peptides are recognized by toll-like receptors (TLRs) on macrophages and dendritic cells.


Having a main partner improves HIV outcomes.

The repeat-variable diresidue (RVD) in the loop of Transcription-Activator Like (TAL) effectors specifies the nucleotides-amino acid contact at the target promoter element.

Pharmacist attendance at ward rounds reduces adverse events in wards.

Sepsis related mortality has risen from 2009 to 2014.

Klf4 is important for proper myeloid cell differentiation.

The DESMOND program demonstrates no significant impact on biochemical outcomes.

Angiotensin converting enzyme inhibitors are associated with decreased risk for functional renal insufficiency.

IL-10 production by monocytes inhibits CD4 + T cell response.

Toll-like receptor (TLR) signaling is involved in the pathogenesis of human MDS.

Rapid phosphotransfer rates are correlated with histidine kinase regulator specificity.

Activation of PPM1D enhances p53 function.

Having a main partner worsens HIV outcomes.

Patients in stable partnerships progress from HIV to death at the same rate as patients not in partnerships.

Patients in stable partnerships have a slower progression from HIV to AIDS.

Exhaustion of B cells contributes to poor Ab response in HIV-infected individuals.

ART substantially reduces infectiveness of HIV-positive people.

Chronic HIV stimulation of B cells leads to the premature exhaustion of B cells.

ART has no effect on the infectiveness of HIV-positive people.

Self-advocacy training is effective at decreasing homelessness.

Antiretroviral therapy increases rates of tuberculosis across a broad range of CD4 strata.


Having a main partner worsens HIV outcomes.

HOXB4 is a highly expressed component of cellular secretome from fetal liver cell populations.

The minor G allele of FOXO3 downregulates pro-inflammatory cytokines.

Risedronate increases risk of vertebral and non-vertebral fractures.

For every 1,000 children with cerebral palsy, more than 300 of them are premature or underweight at birth.

The predominant localization of Linc00173 is in mononuclear macrophage nuclei.

cSMAC formation represses weak ligand signalling.

Increased LDL receptors plays a role in the reduction of plasma Lp(a).

Egr3 regulates the homeostasis of B and T cells.

FoxO3a activation in neuronal death is inhibited by reactive oxygen species (ROS).

Low nucleosome occupancy correlates with high methylation levels across species.

Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission.


HbA1c consistently overestimates glycemic control in black individuals with Sickle cell trait (SCT).

Intra-cerebroventricular infusion of amyloid-β oligomers increases expression of fibronectin type-III domain-containing protein 5 mRNA in mice hippocampi.

Ly6C hi monocytes have a higher inflammatory capacity than Ly6C lo monocytes.

Environmental factors can influence the development of breast cancer.

Induced hepatic stem cells possess the potential to differentiate into cholangiocytic cells.

Human embryonic stem cells give rise to cell types from all three embryonic germ layers.

ART substantially reduces infectiveness of HIV-positive people.

C2 works synergistically with A-769662 to activate dephosphorylated AMPK.

Cellular clocks are associated with mitosis timing in NIH 3T3 cells.

The World Health Organization's (WHO) data collection process is biased downward by unequal selection of larger outbreaks.

p16INK4A degradation is encoded by CDKN2A.

A high microerythrocyte count protects against severe anemia in homozygous alpha (+)- thalassemia trait subjects.

The M2-phenotype in brown adipose tissue macrophages increases brown adipose tissue thermogenic activity.

Mutant mice lacking SVCT2 have severely reduced ascorbic acid levels in both brain and adrenals.

The morphology change from large white adipocytes to small brown adipocytes is a sign of decreased energy expenditure potential in white adipose tissue.

Ca2+ cycling controls whole-body energy homeostasis in beige fat.

The morphology change from large white adipocytes to small brown adipocytes is a sign of increased energy expenditure potential in white adipose tissue.

Physical activity level has no association with the difference in maximal oxygen consumption between black and white youth.

The minor G allele of FOXO3 is related to less severe symptoms of Crohn's Disease.

A deficiency of vitamin B12 decreases blood levels of homocysteine.


Headaches are correlated with cognitive impairment.

PKG-la does not have a large impact on expression of spinal long term potentiation in PGK-la knockout mice.

British female students are bullied more than British male students.

Upregulation of PD1 causes the upregulation of Satb1.

A deficiency of folate increases blood levels of homocysteine.

Pyridostatin decreases telomere fragility in BRCA2-deficient cells.

4-PBA treatment raises endoplasmic reticulum stress in response to general endoplasmic reticulum stress markers.

Long chain polyunsaturated fatty acids supplementation is associated with lower rates of atopic eczema at 1 year.

The generation of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells.

miR-142-5P is a known regulator of raised body temperature.

Tuberculosis incidence occurs at higher rates in more sparsely populated areas in the UK.

Physical activity does not improve cognitive function in individuals with Alzheimers.

Antidepressants increase the severity of migraines.

Antidepressants reduce the severity of migraines.

Individuals with Alzheimers who participate in six months of physical activity improve cognitive function for up to 18 months.

Asymptomatic visual impairment screening in elderly populations leads to improved vision.

Patients with panic anxiety show decreased CSF levels of hypocretin.

Exposure to fine particulate air pollution is unrelated to anxiety prevalence.

Cognitive behavioral therapy is an ineffective treatment for insomnia


Healthy volunteers exhibit rapid and transient increase of cellular ATP after being bolus-injected with fructose.

Ribosomopathies have a high degree of cell and tissue specific pathology.

Nonsteroidal antinflammatory drugs are ineffective as cancer treatments.

Interleukin-18 plays an important role in the pathogenesis of atherosclerosis.

Pseudogene PTENP1 encodes a transcript that regulates PTEN expression.

AMP-activated protein kinase (AMPK) activation reduces inflammation-related fibrosis in the lungs.

Tirasemtiv has no effect on cardiac muscle.

Asymptomatic visual impairment screening in elderly populations leads to improved vision.

The NF-κB essential modulator gene induces intestinal inflammation by promoting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death.

The minor G allele of FOXO3 up-regulates IL-10.

Rhythmic expression of Cry1 translates directly into a circadian regulation of cAMP signaling in hepatic glucose metabolism.

Energy balance requires hypothalamic glutamate neurotransmission.

Glucose restriction to 0.05% reduces RLS (replicative life span) by 20-40% in S. cerevisiae.

Ethanol stress increases the expression of IBP in bacteria.

The M2-phenotype in brown adipose tissue macrophages increases brown adipose tissue thermogenic activity.

The morphology change from large white adipocytes to small brown adipocytes is a sign of increased energy expenditure potential in white adipose tissue.

Ethanol stress increases the expression of PSP in bacteria.

Hypothalamic glutamate neurotransmission is unrelated to energy balance.


Helicobacter pylori-induced aberrant NF-kB-dependent expression of activation-induced cytidine deaminase contributes to the mutagenesis of host DNA.

R2D2 stops miRNA production by increasing the selectivity of Dcr2 for long dsRNA.

During non-homologous end joining, the ligation step is not as tolerant of disrepairs and other distortions when joining 3' of strand breaks as compared to 5' strand breaks.

The NF-κB essential modulator gene prevents intestinal inflammation by inhibiting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death.

H4 G94P proteins induce degradation of free histones via Rad53-dependent mechanisms.

In breast cancer, the loss of myoepithelial cells promotes the transition of ductal carcinoma in situ to invasive carcinoma.

Genes regulated by Esrrb transcription factor are sensitive to Mbd3 function.

Basophils promote disease development in patients with systemic lupus erythematosus (SLE).

Mutations in RIM1 raise levels of IME1 RNA.

Glioblastoma multiforme (GBM) is characterized by extensive invasion, rapid growth, necrosis, and angiogenesis.

The minor G allele of FOXO3 downregulates pro-inflammatory cytokines.

Replacement of histone H2A with H2A.Z accelerates gene activation in yeasts by destabilizing +1 nucleosomes.

Citrullinated proteins externalized in neutrophil extracellular traps act indirectly to perpetuate the inflammatory cycle via induction of autoantibodies.

RA activation of DIF2 and NB4 cells induces hallmarks of transcriptionally active promoters.

Lysine histone demethylase inhibitor JIB 04 is inactive against KDM5A.

Cancer cells can stimulate the accumulation of intra-tumoural myeloid-derived suppressor cells by promoting granulocyte colony stimulating factor production.

Activation of the Rac1 homolog CED-10 kills viable cells in SRGP-1 mutant Caenorhabditis elegans.

Removal of H3K9me3 by ectopic expression of other H3K9 demethylases decreases reprogramming efficiency in SCNT experiments.

The generation of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells.

Removal of H3K9me3 by ectopic expression of other H3K9 demethylases improves reprogramming efficiency in SCNT experiments.


Helminths interfere with immune system control of coinfections by microbial pathogens 16.

A T helper 2 cell (Th2) environment impedes disease development in patients with systemic lupus erythematosus (SLE).

Up-regulation of the p53 pathway and related molecular events speeds cancer progression.

CD28 initiates tonic signaling in conventional T cells, which causes an exhaustion phenotype and limited efficiency.

Ribosomal protein (RP) expression is controlled in part by stress-activated regulators.

The DEXI promoter region is bound by multiple transcription factors in a murine haematopoietic progenitor cell line.

Microglia are an innate immune cell type of the central nervous system.

The cytokine receptor which regulates chemotaxis and formation of lymph nodes is involved in production of myeloperoxidase in the left atrium.

CD44v6 is not associated with constitutive and reprogrammed cancer stem cells driving cancer metastasis.

Satellite cell dysfunction is a key factor in sarcopenia development.

The gene daf-16, which encodes forkhead Box O (FOXO), is required for all phenotypes associated with reduced insulin/insulin-like growth factor (Igf) signaling.

Albendazole is used to treat soil-transmitted helminths.

Bacteriophagaes MS2 and Qβ are members of the Leviviridae.

Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 inhibit West Nile virus replication in cortical neurons.

Commelina yellow mottle virus (ComYMV) has three typical badnavirus ORFs, capable of encoding proteins 23, 15, and 216 kD.

Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection increases dissemination of Salmonella Typhimurium from the gut.

Nonhuman primates are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.

Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection decreases dissemination of Salmonella Typhimurium from the gut.

The deamination of cytidine to uridine on the minus strand of viral DNA can inactivate the viral genome by inducing G-to-A mutations.

Eilat virus (EILV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in nonhuman primates.


Hematopoietic Stem Cell purification reaches purity rates above 90%.

Cellular clocks are not predictive of mitosis timing in NIH 3T3 cells.

miRNAs regulate a unique suite of mRNAs to maintain homeostasis in cells.

Stiff substrates inhibit mesodermal differentiation by degrading beta-catenin in an integrin-dependent manner.

Physical activity level has no association with the difference in maximal oxygen consumption between black and white youth.

GATA3 regulates cell cycle progression in bone marrow hematopoietic stem cells.

Chinese individuals with TT homozygosity in the MTHFR gene are less vulnerable to strokes caused by low levels of folate intake.

Helminths interfere with immune system control of coinfections by microbial pathogens 16.

Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 inhibit West Nile virus replication in cortical neurons.

Neutrophil extracellular trap (NET) antigens may contain the targeted autoantigens PR3 and MPO.

Students who perform poorly in the early years of medical school are at increased risk for professional misconduct later in their careers.

A low percentage of hematopoietic progenitor cells are susceptible to HIV-1 infection ex vivo.

Induced hepatic stem cells possess the potential to differentiate into hepatocytic cells.

Induced hepatic stem cells possess the potential to differentiate into cholangiocytic cells.

Androgenetic haploid mouse embryonic stem cells (ESCs) can be derived and genetically manipulated in vitro.

HOXB4 facilitates HSC expansion when co-cultured with HSCs.

Human embryonic stem cells have the capacity to give rise to differentiated progeny representative of all three embryonic germ layers.

High levels of CRP lead to a higher risk of exacerbations in chronic obstructive pulmonary disease (COPD).

Specialized functional cell types can be derived from human pluripotent stem cells.


High levels of CRP lead to a higher risk of exacerbations in chronic obstructive pulmonary disease (COPD).

0-dimensional biomaterials lack inductive properties.

Reducing H3k4me3 methylation induces mouse epiblast stem cells to naive pluripotency efficiently.

Charcoal is an effective treatment for acute paraquat poisoning.

Myelin sheaths play a role in action potential propagation.

Acute ablation of Snail in the embryonic cortex affects the proliferation and number of embryonic cortical precursors.

Reduced responsiveness to interleukin-2 in regulatory T cells is associated with autoimmune diseases such as Type 1 Diabetes.

Microglia are an innate immune cell type of the peripheral nervous system.

Cell autonomous sex determination in somatic cells occurs in Galliformes.

Cancer cells can stimulate the accumulation of intra-tumoural myeloid-derived suppressor cells by promoting granulocyte colony stimulating factor production.

There is no relation between Erythromycin use and hypertrophic pyloric stenosis.

CRP is positively correlated with postoperative mortality following Coronary Artery Bypass Graft (CABG) surgery.

Decreased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm.

Increased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm.

Diabetic patients with acute coronary syndrome experience decreased short-term and long-term risk for bleeding events.

AMP-activated protein kinase (AMPK) activation reduces inflammation-related fibrosis in the lungs.

Exposure to fine particulate air pollution is unrelated to anxiety prevalence.

Participants who quit smoking reduce lung cancer risk by approximately 50%.

Decreased conversion of PGE 2 to PPARy ligand 15-ket-PGE 2 causes accumulation of PGE.

Increased conversion of PGE 2 to PPARy ligand 15-ket-PGE 2 causes accumulation of PGE.


Higher plasma levels of I-carnitine, when associated with trimethylamine N-oxide, are negatively correlated with cardiovascular events in humans.

N348I mutations reduce resistance to nevirapine.

Glycan adaptation involves insertion-deletion events.

Ca2+ cycling controls whole-body energy homeostasis in beige fat.

Tuberculosis incidence occurs at higher rates in more sparsely populated areas in the UK.

Alirocumab treatment reduces apo(a) fractional clearance rate.

70% of burn patients are admitted for hospitalization and further treatment after appearing at hospital emergency wards or outpatient clinics.

Upon viral challenge, influenza-specific memory CD4+ T cells greatly enhance the early production of inflammatory chemokines in the lung.

Chlamydia trachomatis is most prevalent in the UK among individuals in their 50s and 60s.

The risk of female prisoners harming themselves is ten times that of male prisoners.

Transcription rates in S. cerevisiae range between 7 and 12 kb/min.

Higher plasma levels of I-carnitine, when associated with trimethylamine N-oxide, are positively correlated with cardiovascular events in humans.

Omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegetarians.

Omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegans.

Omnivores produce less trimethylamine N-oxide from dietary I-carnitine than vegans.

Sildenafil worsens erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.

LDL cholesterol has a causal role in the development of cardiovascular disease.

A deficiency of folate increases blood levels of homocysteine.

There is no increased risk of hypospadias with clomiphene.

A deficiency of vitamin B12 decreases blood levels of homocysteine.


Higher plasma levels of I-carnitine, when associated with trimethylamine N-oxide, are positively correlated with cardiovascular events in humans.

Folate and vitamin B12 levels influence the association between homocysteine and preeclampsia.

The microtubule-dependent delivery and secretion of matrix metalloproteases (MMPs) is partially responsible for the disassembly of adhesion sites.

RANK-RANKL pathway signalling has no known association with development of Aire-expressing medullary thymic epithelial cells.

The proliferative capacity of progenitors is regulated cell-autonomously.

The effect of Lipopolysaccharides on kidney barrier function is dependent on inflammation levels.

In S. cerevisiae, the absence of RNA surveillance pathways causes sensitivity to high iron conditions.

Aged patients are more susceptible to ischaemia/reperfusion injury.

Over half of the gabonese children with Schimmelpenning-Feuerstein-Mims syndrome (SFM) had a plasma lactate of more than 5mmol/L.

CDK6 shows improved binding to loss-of-function variants of p18 INK4C.

AMP-activated protein kinase (AMPK) activation reduces inflammation-related fibrosis in the lungs.


Homozygous deletion of murine Sbds gene from osterix-expressing mesenchymal stem and progenitor cells (MPCs) induces oxidative stress.

During non-homologous end joining, the ligation step is not as tolerant of disrepairs and other distortions when joining 5' of strand breaks as compared to 3' strand breaks.

Ribosomopathies have a high degree of cell and tissue specific pathology.

Lack of FGF21 in mice increases life expectancy.

p75 NTR - associated cell death executor (NADE) interacts with the p75 NTR death domain

Mice defective for deoxyribonucleic acid (DNA) polymerase I (polI) fail to reveal increased sensitivity to ionizing radiation (IR).

miR-142-5P is a temperature-sensitive microRNA (miRNA).

Men are more susceptible to death due to pneumonia when compared to women.

In the UK, drowning affects boys and girls equally.

Students who perform poorly in the early years of medical school are at increased risk for professional misconduct later in their careers.

Increased mobility of retrotransposons is assosciated with mutation and higher tumorigenesis rates.

Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection increases dissemination of Salmonella Typhimurium from the gut.

Autologous transplantation of mesenchymal stem cells has better graft function than induction therapy with anti-interleukin-2 receptor antibodies.

Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection decreases dissemination of Salmonella Typhimurium from the gut.

Increased mobility of retrotransposons does not lead to mutation and higher tumorigenesis rates.

The latent infection of myeloid cells with human cytomegalovirus induces a number of changes in gene expression.

The DEXI promoter region is bound by multiple transcription factors in a murine haematopoietic progenitor cell line.

siRNA knockdown of A20 slows tumor progression in an in vivo murine xenograft model.

siRNA knockdown of A20 accelerates tumor progression in an in vivo murine xenograft model.


Human embryonic stem cells give rise to cell types from all three embryonic germ layers.

Pre-mRNAs associated with spliceosomal components are less stable than unassociated splicing substrates.

Higher plasma levels of I-carnitine, when associated with trimethylamine N-oxide, are positively correlated with cardiovascular events in humans.

Tuberculosis-induced granulomas express different immune system protein signatures than the surrounding tissue.

Patients in stable partnerships progress from HIV to death at the same rate as patients not in partnerships.

The risk of breast cancer among parous women decreases with placental weight of pregnancies.

C2 works synergistically with A-769662 to activate dephosphorylated AMPK.

Pseudogene PTENP1 encodes a transcript that regulates PTEN expression.

Lack of FGF21 in mice leads to atherosclerotic plaque formation.

The composition of myosin-II isoform switches from the A isoform to the B isoform during hematopoietic differentiation.

Whole brain radiotherapy increases the occurrence of new brain metastases.

Human embryonic stem cells have the capacity to give rise to differentiated progeny representative of all three embryonic germ layers.

Human embryonic stem cells give rise to cell types from the outer embryonic germ layer, but not the other two layers.

Androgenetic haploid mouse embryonic stem cells (ESCs) can be derived and genetically manipulated in vitro.

Cellular differentiation of embryonic stem cells is accompanied by changes in replication timing, transcription and nuclear localization.

Specialized functional cell types can be derived from human pluripotent stem cells.

Adult tissue-resident macrophages stem from the embryonal yolk sac and fetal liver.

Nuclear transfer from adult human fibroblasts to human oocytes can give rise to blastocysts containing expandable pluripotent cells.

The myocardial cell lineage originally develops from cardiac progenitors of exclusively endodermal origin.


Human embryonic stem cells give rise to cell types from the outer embryonic germ layer, but not the other two layers.

Intake of folic acid (FA) and vitamin B6 (VB6) reduces levels of homocysteine.

Glycan adaptation involves insertion-deletion events.

Bacterial meningitis can be diagnosed on the basis of positive cerebrospinal fluid (CSF) cultures.

Higher plasma levels of I-carnitine, when associated with trimethylamine N-oxide, are negatively correlated with cardiovascular events in humans.

Walking in traffic areas in London did not improve lung function in elderly adults.

Female carriers of the Apolipoprotein E4 (APOE4) allele have increased risk for Alzheimer's disease.

A deficiency of folate increases blood levels of homocysteine.

The proportion of people with visual difficulty is two times higher in low-income countries than in high-income countries.

PGE 2 suppresss intestinal tumor growth by altering the expression of tumor suppressing and DNA repair genes.

Therapeutics receiving accelerated approval encounter a lower frequency of post-marketing safety events

Bone marrow cells don't contribute to adult macrophage compartments.


Human embryonic stem cells have the capacity to give rise to differentiated progeny representative of all three embryonic germ layers.

53% of perinatal mortality is due to low birth weight.

Citrullinated proteins externalized in neutrophil extracellular traps act indirectly to perpetuate the inflammatory cycle via induction of autoantibodies.

Long - range chromatin interactions regulate transcription.

The mean suicide rate in women is lower after miscarriage than live birth.

Acute ablation of KRAS causes severe growth impairment.

Surfactin producing cells and exopolymer producing cells cooperate to generate "Van Gogh" bundles that have sliding abilities on specialized media.

Insulin effects appetite via ventral tegmental neurons.

Ten percent (10%) of kidney cancers in the UK are attributable to excess weight.

Chenodeoxycholic acid treatment decreases brown adipose tissue activity.

Lack of FGF21 in mice leads to atherosclerotic plaque formation.


Hypocretin neurones suppress panicprone state in rats.

Increased mobility of retrotransposons does not lead to mutation and higher tumorigenesis rates.

p16INK4A degradation is encoded by CDKN2A.

Genes regulated by Esrrb transcription factor are sensitive to Mbd3 function.

0-dimensional biomaterials lack inductive properties.

Genetic deletion of JAM-A increases gut permeability.

Glucose restriction to 0.05% reduces RLS (replicative life span) by 20-40% in S. cerevisiae.

Many transmembrane receptors transmit signals by long-range conformational changes in the association of alpha-helices across the plasma membrane.

miRNAs regulate a unique suite of mRNAs to maintain homeostasis in cells.

Increased purity of cytoplasmic membranes isolated from overexpressors is indicated by stronger spots for OmpF in 2D BN-PAGE gels.

Patients with panic anxiety show decreased CSF levels of hypocretin.

Pediatric SCD patients with vaso-occlusive crisis show increased morphine use after breathing 80 ppm iNO for 4 hours.

Antidepressants increase the severity of migraines.

Side effects associated with antidepressants increases risk of stroke.

Side effects associated with antidepressants lower risk of myocardial infarction.

Mice that lack Interferon-γ or its receptor are highly susceptible to experimental autoimmune myocarditis.

Antidepressants reduce the severity of migraines.

In patients with congenital heart defects, β-blockers significantly improve clinical heart failure outcomes.

Hypothalamic glutamate neurotransmission is unrelated to energy balance.


Hypothalamic glutamate neurotransmission is unrelated to energy balance.

Peroxynitrite is required for induction of T cell tolerance.

A 100g dose of chloroquine chemoprophylactic regimen results in retinal toxicity after 5-6 years of weekly intake.

In young and middle-aged adults, current or remote uses of ADHD medications increase the risk of serious cardiovascular events.

In S. cerevisiae, the absence of RNA surveillance pathways reduces sensitivity to high iron conditions.

Persister cells provide relapse resistance in cancer patients.

Patients with common epithelial cancers  are more likely to have an emergency event as their first hospital admission if they live in resource-deprived areas.

Enhanced early production of inflammatory chemokines damages viral control in the lung.

MafA phosphorylation decreases its ubiquitination.

Understanding epigenetic regulation of replication is essential for the reational design of episomally replicating vectors.

MafA ubiquitination increases the recruitment of coavtivator P/CAF by MafA.

Energy balance requires hypothalamic glutamate neurotransmission.

Insulin effects appetite via ventral tegmental neurons.

Oxidative phosphorylation is one of the primary glycometabolic pathways in cells.

Rhythmic expression of Cry1 translates directly into a circadian regulation of cAMP signaling in hepatic glucose metabolism.

Occipital activation levels are associated with auditory spatial performance in parietal regions of the brain.

Increased lipolysis leads to higher P38 phosphorylation in adipose tissue.

Headaches are correlated with cognitive impairment.

Reduced levels of lipolysis leads to higher P38 phosphorylation in adipose tissue.


IFI16 impedes STING phosphorylation and translocation, resulting in reduced activation of STING.

Lack of FGF21 in mice leads to atherosclerotic plaque formation.

Ethanol stress increases the expression of PSP in bacteria.

The repeat-variable diresidue (RVD) in the loop of Transcription-Activator Like (TAL) effectors specifies the nucleotides-amino acid contact at the target promoter element.

TNFAIP3 is a glioblastoma tumor enhancer.

Glycan adaptation involves insertion-deletion events.

The risk of breast cancer among parous women decreases with placental weight of pregnancies.

During non-homologous end joining, the ligation step is not as tolerant of disrepairs and other distortions when joining 3' of strand breaks as compared to 5' strand breaks.

Microglia are an innate immune cell type of the peripheral nervous system.

In domesticated populations of Saccharomyces cerevisiae, segmental aneuploidy occurs infrequently.

Many cytokines that are produced by cancer cells also contribute to carcinogenesis.

Oxidative DNA damage inhibits STING signalling.

Oxidative DNA damage activates STING signalling.

KRT17 modulates the expression of the transcriptional regulator AIRE in diseased epithelia.

p16INK4A degradation is  linked to an abnormal wound response caused by the microinvasive step of advanced Oral Potentially Malignant Lesions (OPMLs).

ITAM phosphorylation allows for the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).

Low expression of miR7a does not repress target genes or exert a biological function in testis.

CDK6 shows impaired binding to loss-of-function variants of p18 INK4C.

Deltex has no known interactions with eIF3f.

JMJD6 catalyzes the hydroxylation of C-terminal lysine and supresses transcriptional activity.


IFIT1 speeds viral replication by allowing for the proliferation of mis-capped viral RNAs.

Treatment with a protein named FN restores regenerative abilities of aged muscles.

De novo assembly of sequence data has shorter contigs than unassembled sequence data.

There was an estimated 30 million cases of pneumonia in young children worldwide in 2010.

Upon viral challenge, influenza-specific memory CD4+ T cells greatly diminish the early production of inflammatory chemokines in the lung.

Diminished ovarian reserve is a reliable indicator of infertility in a non-infertile population.

MEK inhibitors are effective treatments in RAS-driven mouse models of cancer.

An M2-like phenotype in brown adipose tissue macrophages is quickly induced by cold exposure.

There is a relation between Erythromycin use and hypertrophic pyloric stenosis.

Myelin sheaths play a role in action potential propagation.

VgrG (Tssl) protein punctures membranes by forming a spike at the tip of the tube apparatus.

Mutations in RIM1 decrease levels of IME1 RNA.

Mutations in RIM1 raise levels of IME1 RNA.

Recognition of start codons depends on the translation initiation factor IF3.

Genes involved in pre-mRNA splicing have a significant impact on genome stability.

LSD1-positive promoters are associated with RNA polymerase II

Pre-mRNAs associated with spliceosomal components are more stable than unassociated splicing substrates.

Pre-mRNAs associated with spliceosomal components are less stable than unassociated splicing substrates.

miRNAs regulate a unique suite of mRNAs to maintain homeostasis in cells.

Understanding epigenetic regulation of replication is essential for the reational design of episomally replicating vectors.


IL-10 production by monocytes inhibits CD4 + T cell response.

Intake of folic acid (FA) and vitamin B6 (VB6) increases levels of homocysteine.

Gastric infection with Helicobacter pylori increases risk of gastric cancer in humans.

Deregulation of HAND2 is a crucial step in endometrial carcinogenesis in mice.

Patients in stable partnerships have a slower progression from HIV to AIDS.

Patients with common epithelial cancers  are more likely to have an emergency event as their first hospital admission if they live in resource-deprived areas.

Cytosolic proteins bind to iron-responsive elements on mRNAs coding for TFRC1.

Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection increases dissemination of Salmonella Typhimurium from the gut.

Decreased conversion of PGE 2 to PPARy ligand 15-ket-PGE 2 causes accumulation of PGE.

H4 G94P proteins inhibit chromatin assembly, which decreases free histones.

PD-1 triggering on monocytes enhances IL-10 production by monocytes.

CD28 signals regulate trafficking of murine auto-reactive T cells into target tissues.

Reduced responsiveness to interleukin-2 in regulatory T cells is associated with autoimmune diseases such as Type 1 Diabetes.

IL-6 signaling plays a major role in atherosclerotic cardiovascular disease.

CD28 initiates tonic signaling in conventional T cells, which causes an exhaustion phenotype and limited efficiency.

Major antigen-induced signals from the T cell receptor and secondary signals from costimulatory receptors are required for T cell activation.

Egr2 regulates the homeostasis of B and T cells.

Egr3 regulates the homeostasis of B and T cells.

Type 1 Diabetes is associated with subtle perturbations in T reg development.