Many transmembrane receptors transmit signals by long-range conformational changes in the association of alpha-helices across the plasma membrane.

EGR2 is important to myelination of the peripheral nervous system.

The most prevalent adverse events to Semaglutide are gastrointestinal.

L3MBTL2 binds to H2AK119Ub marked chromatin to form a PRC1 complex.

Mice that lack Interferon-γ or its receptor are highly susceptible to experimental autoimmune myocarditis.

Binding of p53 to enhancer regions (p53BERs) regulates the activity of p53 transcription and cell cycle arrest through the production of p53-dependent eRNAs.

40mg/day dosage of folic acid and 2mg/day dosage of vitamin B12 does not affect chronic kidney disease (CKD) progression.

Kir7.1 modulates channel activity by the G protein-coupled melanocortin-4 receptor (MC4R) in the paraventricular nucleus of the hypothalamus.

Chronic HIV stimulation of B cells leads to the premature exhaustion of B cells.

Propriospinal interneurons that play a role in the plastic reorganization of spinal circuits are integral for recovery from spinal cord injury.

PRC1-bound plasmids sediment at a slower rate in unbound plasmids than in sucrose gradients.

Intramembrane cleavage by signal peptide peptidase aids in the degradation of proteins with a complex membrane orientation.

Ly49Q directs the organization of neutrophil polarization by regulating membrane raft functions.

ITAM phosphorylation allows for the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).

Neutrophils produce IL-1β in response to large particles.

Major antigen-induced signals from the T cell receptor and secondary signals from costimulatory receptors are required for T cell activation.

T cell receptor /CD3 microdomains are required to induce the immunologic synapse.

The density of cytokine receptor bearing cells affects the distance over which cytokines act.

The density of cytokine receptor bearing cells has no effect on the distance over which cytokines act.


Marmosets have a brain region homologous to Broca's area.

Low expression of miR7a does not repress target genes or exert a biological function in ovaries.

Mice lacking Sirt1 in Sf1-expressing neurons are immune to diet-induced obesity and insulin resistance.

Normal granulomas form in the presence of TNF in Zebrafish.

The C-type lectin receptor (CLEC-2) rearranges the actin cytoskeleton in dendritic cells to promote efficient motility along stromal surfaces.

There was an estimated 30 million cases of pneumonia in young children worldwide in 2010.

Mouse models can be generated using "artificial spermatids."

Autophagy deficiency in the liver increases vulnerability to insulin resistance.

Autologous transplantation of mesenchymal stem cells has better graft function than induction therapy with anti-interleukin-2 receptor antibodies.

Genes involved in pre-mRNA splicing have a significant impact on genome stability.

LDL cholesterol has a causal role in the development of cardiovascular disease.

Microglia are an innate immune cell type of the central nervous system.

Microglia are an innate immune cell type of the peripheral nervous system.

In rhesus macaques, daily subcutaneous injections of emtricitabine are ineffective at protecting against rectally transmitted simian-human immunodeficiency virus.

Drosophila supracellular actomyosin structures are found at boundaries in wing imaginal discs.

In rhesus macaques, daily subcutaneous injections of tenofovir protects against rectally transmitted simian-human immunodeficiency virus.

Dscam1 acts as a hypervariable pattern-recognition receptor for the immune system.

Occipital activation levels are associated with auditory spatial performance in parietal regions of the brain.

Lamins are found within the inner layer of the mitochondrial membrane of all cells.


Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission.

Active caspase-11 participate in regulating phagosome-lysosome fusion.

Mice defective for deoxyribonucleic acid (DNA) polymerase m (polm) reveal increased sensitivity to ionizing radiation (IR).

Klf4 is not required for proper myeloid cell differentiation.

Beta-band coherence is enhanced for visible stimuli over invisible stimuli.

Chemical injury represses transglutaminase 2 activity.

Trans-acting factors, such as lncRNAs, influence mRNA translation.

Long - range chromatin interactions regulate transcription.

Rapamycin increases the concentration of triacylglycerols in fruit flies.

Bariatric surgery reduces postmenopausal breast cancer.

Helicobacter pylori-induced aberrant NF-kB-dependent expression of activation-induced cytidine deaminase contributes to the mutagenesis of host DNA.

Antiretroviral therapy increases rates of tuberculosis across a broad range of CD4 strata.

Eliminating the last sporadic cases of malaria requires considerable funding.

Stroke patients with prior use of direct oral anticoagulants have a higher risk of in-hospital mortality than stroke patients with prior use of warfarin.

Rising temperatures caused by global warming increases risk of dengue fever transmission.

A breast cancer patient's capacity to metabolize tamoxifen influences treatment outcome.

Rising temperatures caused by global warming lowers the risk of dengue fever transmission.

Urbanization is an important risk factor related to the transmission of dengue fever.

Patients with microcytosis and higher erythrocyte count are more vulnerable to severe malarial anaemia when infected with Plasmodium falciparum.


MeCP2 influences the synaptic maturation of neurons.

HbA1c consistently overestimates glycemic control in black individuals with Sickle cell trait (SCT).

Understanding epigenetic regulation of replication is essential for the reational design of episomally replicating vectors.

Basophils promote disease development in patients with systemic lupus erythematosus (SLE).

ER-localized phosphatase Sac1 processes PI4P through coordination with OSBP and the endosome-localized protein sorting nexin 2.

Side effects associated with antidepressants lower risk of myocardial infarction.

The predominant localization of Linc00173 is in mononuclear macrophage nuclei.

Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes epithelial damage.

Differentiation of progenitor cells to myeloid cells is skewed when insulin signaling is suppressed.

Ca2+ cycling is a UCP1-dependent thermogenic mechanism.

Genes involved in pre-mRNA splicing have a significant impact on genome stability.

Activation of PPM1D enhances p53 function.

EGR2 is important to myelination of the peripheral nervous system.

The proliferative capacity of neural progenitors differs across species.

Mice lacking Sirt1 in Sf1-expressing neurons have increased susceptibility to diet-induced obesity and insulin resistance.

HIV trans-activator protein (TAT) effectively transports large and small molecules across cellular membranes into larger populations of neurons.

Converting apoE4 to apoE3 by gene editing prevents the pathology associated with apoE4 in human iPSCderived neurons.

Converting apoE4 to apoE3 by gene editing worsens the pathology associated with apoE4 in human iPSCderived neurons.

PKG-la plays an essential role in expression of spinal long term potentiation in PGK-la knockout mice.

Mice lacking Sirt1 in Sf1-expressing neurons are immune to diet-induced obesity and insulin resistance.


Measuring routine outcomes is more beneficial to clinical practice than assessing treatment adherence.

The proliferative capacity of progenitors is regulated cell-autonomously.

Higher plasma levels of I-carnitine, when associated with trimethylamine N-oxide, are positively correlated with cardiovascular events in humans.

Mice lacking Sirt1 in Sf1-expressing neurons have increased susceptibility to diet-induced obesity and insulin resistance.

Pediatric SCD patients with vaso-occlusive crisis show increased morphine use after breathing 80 ppm iNO for 4 hours.

Increased mobility of retrotransposons does not lead to mutation and higher tumorigenesis rates.

Mitochondria play a major role in apoptosis.

Diabetes remission occurs less in people treated with conventional therapy than in people treated with laparoscopic adjustable gastric banding surgery.

NR5A2 is important in reverse cholesterol transport in humans.

Removal of H3K9me3 improves reprogramming efficiency in human somatic cell nuclear transfer experiments.

Assessing treatment adherence is more beneficial to clinical practice than measuring routine outcomes.

Cost effectiveness evaluations based on cRCT data accurately reflect prices for patients in actual clinical practice.

Cost effectiveness evaluations based on cRCT data lack external validity.

Including pharmacists in rounding teams does not alter the incidence of adverse drug events (ADEs).

Including pharmacists in rounding teams reduces the incidence of adverse drug events (ADEs).

Misunderstandings between doctors and patients can lead to non-adherence.

Integrated care is ineffective at tackling multiple comorbidities.

Integrated care is successful at tackling multiple comorbidities.

Therapeutics receiving accelerated approval encounter a lower frequency of post-marketing safety events


Medications to treat obesity are highly effective.

Localization of PIN1 in the roots of Arabidopsis requires VPS9a

PGE 2 suppresss intestinal tumor growth by altering the expression of tumor suppressing and DNA repair genes.

40mg/day dosage of folic acid and 2mg/day dosage of vitamin B12 does not affect chronic kidney disease (CKD) progression.

Forkhead 0 (fox0) transcription factors are involved in cellular differentiation.

There is no relation between Erythromycin use and hypertrophic pyloric stenosis.

MafA phosphorylation enhances its ubiquitination.

Increased LDL receptors plays a role in the reduction of plasma Lp(a).

The myocardial cell lineage originally develops from cardiac progenitors of exclusively endodermal origin.

In breast cancer, the loss of myoepithelial cells slows the transition of ductal carcinoma in situ to invasive carcinoma.

Medications to treat obesity do not have side effects.

Medications to treat obesity have unwanted side effects.

Excess gestational weight gain is associated with obesity-related pregnancy outcomes.

Autophagy deficiency in the liver increases vulnerability to insulin resistance.

Exercise increases cancer mortality rates among Chinese citizens.

Exercise reduces cancer mortality rates among Chinese citizens.

In young and middle-aged adults, current or remote uses of ADHD medications increase the risk of serious cardiovascular events.

Insulin decreases risk of severe kidney failure.

Antidepressants reduce the severity of migraines.


Medications to treat obesity do not have side effects.

Nonsteroidal antinflammatory drugs show potential anticancer indications.

Consumption of whole fruits increases the risk of type 2 diabetes.

Cognitive behavioral therapy is an ineffective treatment for insomnia

Progerin induces premature aging in stem cells.

The RANK-RANK-Ligand (RANKL) pathway is involved in the development of Aire-expressing medullary thymic epithelial cells (mTECs).

Deletion of ATM and Rad3 related protein leads to acute tissue loss.

mcm 5 s 2 U is required for proper decoding of NNR codons in eukaryotes.

The World Health Organization's (WHO) data collection process is biased downward by unequal selection of larger outbreaks.

76-85% of people with severe mental disorder receive no treatment in low and middle income countries.

61% of colorectal cancer patients are diagnosed with regional or distant metastases.

Side effects associated with antidepressants do not represent a mortality risk to postmenopausal women.

Side effects associated with antidepressants increases risk of stroke.

Sildenafil worsens erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.


Medications to treat obesity have unwanted side effects.

The most prevalent adverse events to Semaglutide are gastrointestinal.

There is a relation between Erythromycin use and hypertrophic pyloric stenosis.

Major vault protein regulates sorting of tumor suppressive miR-193a into EVs.

Nonhuman primates are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.

Algerian physicians constitue the largest component of sub-Saharan Africa-trained physicians in the United States.

Exposure to fine particulate air pollution is unrelated to anxiety prevalence.

Induction of urokinase receptor signaling in podocytes causes foot process effacement and proteinuria.

CD44v6 is not associated with constitutive and reprogrammed cancer stem cells driving cancer metastasis.


Men are more susceptible to death due to pneumonia when compared to women.

Students who perform poorly in the early years of medical school are at increased risk for professional misconduct later in their careers.

British female students are bullied more than British male students.

Charcoal shows no benefit for acute paraquat poisoning.

Normal granulomas form in the absence of TNF in Zebrafish.

Physical activity level is associated with the difference in maximal oxygen consumption between black and white youth.

Scapular stabilizer exercises are more effective than general exercise therapy in reducing pain and improving function of the shoulder.

A diminished ovarian reserve does not solely indicate infertility in an a priori non-infertile population.

The NF-κB essential modulator gene induces intestinal inflammation by promoting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death.

eRNAs influence is linked to senescence, aging, and carcinogenesis.

Women are more susceptible to death due to pneumonia when compared to men.

There was an estimated 30 million cases of pneumonia in young children worldwide in 2010.

The mean suicide rate in women is lower after miscarriage than live birth.

The mean suicide rate in women is higher after miscarriage than live birth.

Women with a lower birth weight are more likely to develop breast cancer later in life.

Bacterial meningitis can be diagnosed on the basis of positive cerebrospinal fluid (CSF) cultures.

Tuberculosis incidence occurs at higher rates in more sparsely populated areas in the UK.

Rising temperatures caused by global warming increases risk of dengue fever transmission.

Urbanization is an important risk factor related to the transmission of dengue fever.


Metastatic colorectal cancer treated with a single agent fluoropyrimidines resulted in similar efficacy and better quality of life when compared with oxaliplatin-based chemotherapy in elderly patients.

taa1 tar1 tar2 triple mutants in Arabidopsis do not make root meristem during embryogenesis.

Occipital activation levels are associated with auditory spatial performance in parietal regions of the brain.

Ethanol stress reduces the expression of SRL in bacteria.

The PPR MDA5 has twenty N-terminal CARD domains.

Antiretroviral therapy increases rates of tuberculosis across a broad range of CD4 strata.

Primary cervical cancer screening with HPV detection has lower longitudinal sensitivity than conventional cytology to detect cervical intraepithelial neoplasia grade 2.

HIV trans-activator protein (TAT) effectively transports large and small molecules across cellular membranes into larger populations of neurons.

Ethanol stress increases the expression of PSP in bacteria.

61% of colorectal cancer patients are diagnosed with regional or distant metastases.

The relationship between a breast cancer patient's capacity to metabolize tamoxifen and treatment outcome is independent of the patient's genetic make-up.

1-1% of colorectal cancer patients are diagnosed with regional or distant metastases.

Stroke patients with prior use of direct oral anticoagulants have a higher risk of in-hospital mortality than stroke patients with prior use of warfarin.

Systemic immunosuppressive (IS) therapy increases the chance of cancer mortality in patients with inflammatory eye disease (IED)

Systemic immunosuppressive (IS) therapy does not enhance the chance of cancer mortality in patients with inflammatory eye disease (IED)

Varenicline monotherapy is more effective after 26 weeks of treatment compared to combination nicotine replacement therapies with varenicline or bupropion.

Pioglitazone use is significantly associated with an increased risk of pancreatic cancer.

A breast cancer patient's capacity to metabolize tamoxifen influences treatment outcome.


Mice are incapable of producing neutralizing antibodies in reponse to the Chikungunya virus (CHIKV) produced in mosquitos.

Egr2 regulates the homeostasis of B and T cells.

Fibroblast Growth Factor is a ligand which signals through receptor tyrosine kinases.

Upon viral challenge, influenza-specific memory CD4+ T cells greatly enhance the early production of inflammatory chemokines in the lung.

The amount of publicly available DNA data doubles every 10 months.

Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 inhibit West Nile virus replication in cortical neurons.

Rhythmic expression of Cry1 translates directly into a circadian regulation of cAMP signaling in gluconeogenesis.

Pyridostatin induces checkpoint activation.

Inhibiting HDAC6 increases survival of mice with ARID1A mutated tumors.

R2D2 stops miRNA production by increasing the selectivity of Dcr2 for long dsRNA.

Human embryonic stem cells give rise to cell types from all three embryonic germ layers.

Nonhuman primates are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.

Eilat virus (EILV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in nonhuman primates.

Tuberculosis-induced granulomas express different immune system protein signatures than the surrounding tissue.

Rising temperatures caused by global warming lowers the risk of dengue fever transmission.

In rhesus macaques, daily subcutaneous injections of emtricitabine are ineffective at protecting against rectally transmitted simian-human immunodeficiency virus.

Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission.

Inside the body, falciparum parasites reproduce asexually.


Mice defective for deoxyribonucleic acid (DNA) polymerase I (polI) fail to reveal increased sensitivity to ionizing radiation (IR).

Long chain polyunsaturated fatty acids supplementation is associated with lower rates of atopic eczema at 1 year.

The G34R/V mutation creates a hypomethylated phenotype at the H3K36 histone.

Omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegans.

M. stadtmanae does not induce ASC speck formation in BlaER1 monocytes.

RA activation of DIF2 and NB4 cells induces hallmarks of transcriptionally active promoters.

Pioglitazone use is significantly associated with an increased risk of pancreatic cancer.

Inhibiting glucose-6-phospate dehydrogenase improves lipogenesis by deactivating LKB1-AMPK signaling.

taa1 tar1 tar2 triple mutants in Arabidopsis do not make root meristem during embryogenesis.

In pediatric tissue, most T cells are naive T cell emigrants from the thymus.

COPI coatmer is involved in viral replication.

Mice defective for deoxyribonucleic acid (DNA) polymerase m (polm) fail to reveal increased sensitivity to ionizing radiation (IR).

Mice defective for deoxyribonucleic acid (DNA) polymerase m (polm) reveal increased sensitivity to ionizing radiation (IR).

PrimPol degrades short DNA replication intermediates on the leading strand during DNA replication.

The deamination of cytidine to uridine on the minus strand of viral DNA can inactivate the viral genome by inducing G-to-A mutations.

PrimPol generates short DNA replication intermediates on the leading strand during DNA replication.

p16INK4A degradation is  linked to an abnormal wound response caused by the microinvasive step of advanced Oral Potentially Malignant Lesions (OPMLs).

Neutrophils produce IL-1β in response to large particles.

Higher plasma levels of I-carnitine, when associated with trimethylamine N-oxide, are negatively correlated with cardiovascular events in humans.

Reduction of purity of cytoplasmic membranes isolated from overexpressors is indicated by stronger spots for OmpA in 2D BN-PAGE gels.


Mice defective for deoxyribonucleic acid (DNA) polymerase m (polm) fail to reveal increased sensitivity to ionizing radiation (IR).

The HSV-2 infection is typically asymptomatic.

Tonic signaling from the scFv is amplified by MyD88/CD40.

7-day-old adult Caenorhabditis elegans exhibit approximately 5% of the learning capacity seen in 1-day old adults.

mcm 5 s 2 U is required for proper decoding of NNR codons in eukaryotes.

Decrease of p62 in prostate tumor stroma results in defective autophagy.

Immune responses in immune cells are geographically segregated.

Monoclonal antibody targeting of N-cadherin encourages metastasis.

Major antigen-induced signals from the T cell receptor and secondary signals from costimulatory receptors are required for T cell activation.

Bariatric surgery increases rates of postmenopausal breast cancer.

Lamins have no effect on nuclear membrane structure maintenance.

R2D2 stops miRNA production by increasing the selectivity of Dcr2 for long dsRNA.


Mice defective for deoxyribonucleic acid (DNA) polymerase m (polm) reveal increased sensitivity to ionizing radiation (IR).

ER-localized phosphatase Sac1 processes PI4P through coordination with OSBP and the endosome-localized protein sorting nexin 2.

Klf2 is important for proper myeloid cell function.

Approximately 250,000 people are infected with human T-cell lymphotropic virus type 1 in the United Kingdom.

Foxp3 represses the expression of transcriptional regulators implicated in memory T cell development.

Long chain polyunsaturated fatty acids supplementation has no significant effects on wheezing or asthma at 3 and 6 years.

There is no relation between Erythromycin use and hypertrophic pyloric stenosis.

Many cytokines that are produced by cancer cells also contribute to carcinogenesis.

Suboptimal nutrition is a leading cause of premature death

Angiotensin converting enzyme inhibitors are associated with decreased risk for functional renal insufficiency.

Reduction of purity of cytoplasmic membranes isolated from overexpressors is indicated by stronger spots for OmpF in 2D BN-PAGE gels.


Mice lacking Sirt1 in Sf1-expressing neurons are immune to diet-induced obesity and insulin resistance.

Integrated care is successful at tackling multiple comorbidities.

Genomic sequences involved in alternative splicing responsible for Hutchinson-Gilford progeria syndrome (HGPS) are abundant in the ''progerinonly'' allele of Lmna knock-in models.

In rhesus macaques, daily subcutaneous injections of tenofovir protects against rectally transmitted simian-human immunodeficiency virus.

Post-transcriptional handling of mitochondrial transcripts occurs in mitochondrial RNA granules.

Pyridostatin prevents double-strand breaks accumulation.

Omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegans.

Glucose restriction to 0.05% reduces RLS (replicative life span) by 20-40% in S. cerevisiae.

Therapeutics receiving accelerated approval encounter a lower frequency of post-marketing safety events

Sepsis related mortality has risen from 2009 to 2014.

Mice lacking Sirt1 in Sf1-expressing neurons have increased susceptibility to diet-induced obesity and insulin resistance.

Mutant mice lacking SVCT2 have severely reduced ascorbic acid levels in both brain and adrenals.

Autophagy deficiency in the liver increases vulnerability to insulin resistance.

Lack of FGF21 in mice leads to reduced lifespan.

Lack of FGF21 in mice increases life expectancy.

HIV trans-activator protein (TAT) effectively transports large and small molecules across cellular membranes into larger populations of neurons.

Lack of FGF21 in mice leads to atherosclerotic plaque formation.

Lack of FGF21 in mice slows the rate of atherosclerotic plaque formation.

Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes fibrosis.


Mice lacking Sirt1 in Sf1-expressing neurons have increased susceptibility to diet-induced obesity and insulin resistance.

The deamination of cytidine to uridine on the minus strand of viral DNA can inactivate the viral genome by inducing G-to-A mutations.

Aged patients are more susceptible to ischaemia/reperfusion injury.

Satellite cell dysfunction is a key factor in sarcopenia development.

Pseudoknots are not evolutionarily conserved in most eukaryotes.

The proportion of people with visual difficulty is two times higher in low-income countries than in high-income countries.

Charcoal is an effective treatment for acute paraquat poisoning.

Tonic signaling from the scFv induces constitutive stimulation.

There is a relation between Erythromycin use and hypertrophic pyloric stenosis.

Mice are incapable of producing neutralizing antibodies in reponse to the Chikungunya virus (CHIKV) produced in mosquitos.

The morphology change from large white adipocytes to small brown adipocytes is a sign of decreased energy expenditure potential in white adipose tissue.


Mice that lack Interferon-γ or its receptor are highly susceptible to experimental autoimmune myocarditis.

The origin of the CRF01_1b2k protein occurred between 1923 and 1956.

Physical activity level has no association with the difference in maximal oxygen consumption between black and white youth.

CDK6 shows improved binding to loss-of-function variants of p18 INK4C.

The mean suicide rate in women is lower after miscarriage than live birth.

Major antigen-induced signals from the T cell receptor and secondary signals from costimulatory receptors are required for T cell activation.

The mean suicide rate in women is higher after miscarriage than live birth.

Reducing H3k4me3 methylation induces mouse epiblast stem cells to naive pluripotency efficiently.

Many cytokines that are produced by cancer cells also contribute to carcinogenesis.

Elevated cell-free mitochondrial DNA levels are associated with mortality.

Active caspase-11 protein promotes pyroptosis.

Mice without IFN-γ or its receptor are highly susceptible to EAM induced with α-MyHC/CFA.

In patients with congenital heart defects, β-blockers significantly improve clinical heart failure outcomes.

The latent infection of myeloid cells with human cytomegalovirus induces a number of changes in gene expression.

Reduced responsiveness to interleukin-2 in regulatory T cells is associated with autoimmune diseases such as Type 1 Diabetes.

Diabetic patients with acute coronary syndrome experience decreased short-term and long-term risk for bleeding events.

IL-6 signaling plays a major role in atherosclerotic cardiovascular disease.

Gpr124 suppresses BBB breakdown in mouse models of ischemic stroke.

High levels of CRP lead to a higher risk of exacerbations in chronic obstructive pulmonary disease (COPD).

The minor G allele of FOXO3 downregulates pro-inflammatory cytokines.


Mice without IFN-γ or its receptor are highly susceptible to EAM induced with α-MyHC/CFA.

p16INK4A degradation is  linked to an abnormal wound response caused by the microinvasive step of advanced Oral Potentially Malignant Lesions (OPMLs).

4-PBA treatment decreases endoplasmic reticulum stress in response to general endoplasmic reticulum stress markers.

Misunderstandings between doctors and patients can lead to non-adherence.

G-CSF increases the expansion and infiltration of MDSCs into tumors.

Measuring routine outcomes is more beneficial to clinical practice than assessing treatment adherence.

Roughly 55% of women with chronic pelvic pain have no underlying pathology.

Upon developing tyrosine-kinase inhibitor resistance, new mutations in epidermal growth factor receptors emerge and cause treatment failure.

Varenicline monotherapy is more effective after 26 weeks of treatment compared to combination nicotine replacement therapies with varenicline or bupropion.

Propriospinal interneurons that play a role in the plastic reorganization of spinal circuits are integral for recovery from spinal cord injury.

Whole brain radiotherapy increases the occurrence of new brain metastases.

Gpr124 increases BBB breakdown in mouse models of ischemic stroke.

The minor G allele of FOXO3 up-regulates IL-10.

Taking anti-depresents is associated with a decrease in the Aβ level in the brain of experimental animals.

FoxO3a activation in neuronal death is inhibited by reactive oxygen species (ROS).

Exposure to fine particulate air pollution is unrelated to anxiety prevalence.

HNF4A mutations are associated with macrosomia in infancy.


Microcin J25 encourages nucleoside triphosphate (NTP) binding.

CHOP is a general endoplasmic reticulum stress marker.

Persistor cells are one reason for incomplete responses to Tyrosine kinase inhibitor (TKI) therapy in cancer patients.

VgrG (Tssl) protein punctures membranes by forming a spike at the tip of the tube apparatus.

Transplanted human glial progenitor cells can mature in their host animal.

Anthrax spores remain deadly until affected areas are decontaminated.

Bacterial meningitis can be diagnosed on the basis of positive cerebrospinal fluid (CSF) cultures.

Men are more susceptible to death due to pneumonia when compared to women.

ScPif1p has reduced binding ability to G-rich ssDNA compared to non-G-rich ssDNA.

NAC inhibits the generation of angiotensin-converting enzyme.

Microcin J25 inhibits nucleoside triphosphate (NTP) binding.

Broadly HIV-1 Neutralizing Antibodies (bnAb) 10EB have no affinity for phospholipids.

Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 encourage West Nile virus replication in cortical neurons.

mcm 5 s 2 U is required for proper decoding of NNR codons in eukaryotes.

MUC1-C activates the NF-κB p65 signaling pathway by interacting with IκB kinase ß.

The Snf1 complex regulates carbon and energy metabolism in baker's yeast (Saccharomyces cerevisiae).

Lack of FGF21 in mice slows the rate of atherosclerotic plaque formation.

Formation of N-terminal pyroglutamate by glutamine cyclase (GC) competes with NTAQ1 for Nt-Gln substrates.


Microcin J25 inhibits nucleoside triphosphate (NTP) binding.

Smc5/6 engagment halts the activation of SUMO E3 ligase Mms21 by ATP-dependent remolding.

Human embryonic stem cells give rise to cell types from the outer embryonic germ layer, but not the other two layers.

Activator-inhibitor pairs are provided ventrally by Xrl-sizzled.

Adult tissue-resident macrophages are seeded before birth.

Ribosome-inactivating protein-2 (RIP-2) interacts with the p75 NTR death domain

Bariatric surgery leads to positive outcomes in mental health.

Pioglitazone use is significantly associated with an increased risk of prostate cancer.

90% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.

Risk-adjusted mortality rates are similar in teaching and non-teaching hospitals.

Foxp3 enables the expression of transcriptional regulators implicated in memory T cell development.

Guanine nucleotide dissociation inhibitor (Rho-GDI) interacts with the p75 NTR death domain

Lack of FGF21 in mice leads to atherosclerotic plaque formation.

p75 NTR - associated cell death executor (NADE) interacts with the p75 NTR death domain


Microglia are an innate immune cell type of the central nervous system.

MafA phosphorylation decreases its ubiquitination.

MICAL redox enzymes regulate actin dynamics in many cell types.

A mutation in HNF4A leads to an increased risk of diabetes by the age of 14 years.

IFIT1 speeds viral replication by allowing for the proliferation of mis-capped viral RNAs.

Inhibiting glucose-6-phospate dehydrogenase improves lipogenesis by deactivating LKB1-AMPK signaling.

53% of perinatal mortality is due to low birth weight.

Albendazole is used to treat soil-transmitted helminths.

The DdrB protein from Deinococcus radiodurans functions as a pentamer.

Genes regulated by Esrrb transcription factor are sensitive to Mbd3 function.

TNFAIP3 is a tumor enhancer in glioblastoma.

Microglia are an innate immune cell type of the peripheral nervous system.

Cancer-associated fibroblasts (CAFs) interact with cancer cells to mediate formation and activation of CAFs.

Cancer-associated fibroblasts (CAFs) are constituents of tumor microenvironments

Cancer-associated fibroblasts (CAFs) have no known interaction with cancer cells in the formation and activation of CAFs.

Immune responses in immune cells are geographically segregated.

Glioblastoma multiforme (GBM) is characterized by extensive invasion, rapid growth, necrosis, and angiogenesis.

miRNAs regulate a unique suite of mRNAs to maintain homeostasis in cells.

Tuberculosis-induced granulomas express different immune system protein signatures than the surrounding tissue.

Dscam1 acts as a hypervariable pattern-recognition receptor for the immune system.


Microglia are an innate immune cell type of the peripheral nervous system.

Moderate consumption of candy and chocolate reduces the risk of cardiovascular disease (CVD).

The tip of the inner tube of the toxic type VI secretion system (T6SS) antibacterial effector in Escherichia coli (E. coli) is decorated with VgrG and PAAR proteins.

Increase of p62 in prostate tumor stroma results in defective autophagy.

Ten percent (10%) of kidney cancers in the UK are attributable to excess weight.

Commelina yellow mottle virus' (ComYMV) genome consists of 2140 baise pairs.

HOXB4 facilitates HSC expansion when co-cultured with HSCs.

Intake of folic acid (FA) and vitamin B6 (VB6) increases levels of homocysteine.

MUC1-C activates the NF-κB p65 signaling pathway by interacting with IκB kinase ß.

Female carriers of the Apolipoprotein E4 (APOE4) allele have longer lifetime exposure to estrogen due to an increased reproductive period.

Increased LDL receptors plays a role in the reduction of plasma Lp(a).

The innate immune response struggles to remove small numbers of parasites.

miR-142-5P is a temperature-sensitive microRNA (miRNA).

Lamins are found within the inner layer of the nuclear membrane of all cells.


Migraine with aura is associated with ischemic stroke.

Ribosomopathies have a high degree of cell and tissue specific pathology.

Sudden death can occur in patients with orthostatic hypertension without cardiac conduction abnormalities.

Nonhuman primates are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.

Excess gestational weight gain is associated with obesity-related pregnancy outcomes.

Nigerian physicians constitue the largest component of sub-Saharan Africa-trained physicians in the United States.

HOXB4 is a highly expressed component of cellular secretome from fetal liver cell populations.

Upregulation of PD1 causes the upregulation of Satb1.

1-1% of colorectal cancer patients are diagnosed with regional or distant metastases.

Reduced phosphorylation of PP2A increases HDAC4 dephosphorylation by enhancing PP2A-HDAC4 interaction.

Perigenital skin is not the primary site of HIV acquisition.

Headaches are correlated with cognitive impairment.

Antidepressants increase the severity of migraines.

Antidepressants reduce the severity of migraines.

Sudden death can occur in patients with complex ventricular arrhythmias.

Exposure to fine particulate air pollution is unrelated to anxiety prevalence.

Decreased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm.

Increased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm.


Misunderstandings between doctors and patients can lead to non-adherence.

Cnn1 recruitment varies with cell cycle timing.

Type 1 Diabetes is associated with subtle perturbations in T reg development.

Mutant mice lacking SVCT2 have severely reduced ascorbic acid levels in both brain and adrenals.

The risk of female prisoners harming themselves is ten times that of male prisoners.

In melanoma, anti-CTLA-4 treatment reinvigorates exhausted PD-1+Eomes+CD8 T cells.

An M2-like phenotype in brown adipose tissue macrophages is quickly induced by cold exposure.

Neutrophil extracellular trap (NET) antigens may contain the targeted autoantigens PR3 and MPO.

Activation of the Rac1 homolog CED-10 kills viable cells in SRGP-1 mutant Caenorhabditis elegans.

Most termination events in Okazaki fragments are dictated by initiation patterns.

Adult tissue-resident macrophages stem from the embryonal yolk sac and fetal liver.

Assessing treatment adherence is more beneficial to clinical practice than measuring routine outcomes.

Measuring routine outcomes is more beneficial to clinical practice than assessing treatment adherence.

Students who perform poorly in the early years of medical school are at increased risk for professional misconduct later in their careers.

Students who perform poorly in the early years of medical school are less likely to commit professional misconduct later in their careers.

Including pharmacists in rounding teams reduces the incidence of adverse drug events (ADEs).

Including pharmacists in rounding teams does not alter the incidence of adverse drug events (ADEs).

Risk-adjusted mortality rates are similar in teaching and non-teaching hospitals.

Integrated care is ineffective at tackling multiple comorbidities.

Cost effectiveness evaluations based on cRCT data accurately reflect prices for patients in actual clinical practice.


Mitochondria play a major role in apoptosis.

Charcoal shows no benefit for acute paraquat poisoning.

Cost effectiveness evaluations based on cRCT data lack external validity.

Cancers that initially benefit from epidermal growth factor receptor targeted therapies later become refractory through several mechanisms.

Polymeal nutrition increases cardiovascular mortality.

TRAP+ osteoclasts regulate mature osteoblast maintenance.

HOXB4 facilitates HSC expansion when co-cultured with HSCs.

One in two surgical randomized controlled trials are discontinued early.

Pseudogene PTENP1 encodes a transcript that regulates PTEN expression.

Trans-acting factors, such as lncRNAs, influence mRNA translation.

British male students are bullied more than British female students.

Mitochondria play a major role in energy production.

Mitochondria play a trivial role in calcium homeostasis.

Cytochrome c is transferred from cytosol to the mitochondrial intermembrane space during apoptosis.

Oxidative phosphorylation is one of the primary glycometabolic pathways in cells.

Cellular clocks are not predictive of mitosis timing in NIH 3T3 cells.

Cellular clocks are associated with mitosis timing in NIH 3T3 cells.

Cyclin A2 destruction is necessary to switch from unstable to stable kt-mt attachments in mitosis.

Binding of p53 to enhancer regions (p53BERs) regulates the activity of p53 transcription and cell cycle arrest through the production of p53-dependent eRNAs.

Forkhead 0 (fox0) transcription factors are involved in apoptosis.


Mitochondria play a major role in energy production.

A mutation in HNF4A leads to an increased risk of diabetes by the age of 14 years.

Patients with common epithelial cancers are less likely to have an emergency event as their first hospital admission if they live in resource-deprived areas.

PKG-la plays an essential role in expression of spinal long term potentiation in PGK-la knockout mice.

Patients with microcytosis and higher erythrocyte count were more resistant to severe malarial anaemia when infected with Plasmodium falciparum.

Commelina yellow mottle virus (ComYMV) has three typical badnavirus ORFs, capable of encoding proteins 23, 15, and 216 kD.

Clathrin stabilizes the spindle fiber apparatus during mitosis.

L3MBTL2 binds to H2AK119Ub marked chromatin to form a PRC1 complex.

Venules have less significant tunica adventitia than arterioles.

Female carriers of the Apolipoprotein E4 (APOE4) allele have longer lifetime exposure to estrogen due to an increased reproductive period.

Cardiac tissue-resident macrophages directly contribute to electrical activity.

The Snf1 complex regulates carbon and energy metabolism in baker's yeast (Saccharomyces cerevisiae).

Nuclear transfer from adult human fibroblasts to human oocytes can give rise to blastocysts containing expandable pluripotent cells.

Long - range chromatin interactions regulate transcription.


Mitochondria play a trivial role in calcium homeostasis.

Long chain polyunsaturated fatty acids supplementation reduces wheezing and asthma.

Induced hepatic stem cells possess the potential to differentiate into cholangiocytic cells.

The peak incidence of fractures occurs in toddlers.

H4 G94P proteins induce degradation of free histones via Rad53-dependent mechanisms.

Pyridostatin prevents double-strand breaks accumulation.

JMJD6 catalyzes the hydroxylation of C-terminal lysine and supresses transcriptional activity.

Egr3 regulates the homeostasis of B and T cells.

Therapeutics receiving accelerated approval encounter a lower frequency of post-marketing safety events

Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection decreases dissemination of Salmonella Typhimurium from the gut.

Genetic deletion of JAM-A increases gut permeability.

MICAL redox enzymes regulate actin dynamics in many cell types.

Ca2+ cycling controls whole-body energy homeostasis in beige fat.


Moderate consumption of candy and chocolate reduces the risk of cardiovascular disease (CVD).

Immune complex triggered cell death leads to sequestration of oxidized mitochondrial DNA.

Patients with common epithelial cancers  are more likely to have an emergency event as their first hospital admission if they live in resource-deprived areas.

Active caspase-11 participate in regulating phagosome-lysosome fusion.

Aged patients are more susceptible to ischaemia/reperfusion injury.

Expression of MSX2 is induced 3 hours after the addition of BMP4, which is earlier than T and CDX2.

Incidence of heart failure increased by 10% in women since 1979.

Commelina yellow mottle virus' (ComYMV) genome consists of 2140 baise pairs.

Cost effectiveness evaluations based on cRCT data accurately reflect prices for patients in actual clinical practice.

Mice lacking Sirt1 in Sf1-expressing neurons have increased susceptibility to diet-induced obesity and insulin resistance.

Most termination events in Okazaki fragments are dictated by initiation patterns.

It is not proven that moderate consumption of candy and chocolate reduces the risk of cardiovascular disease (CVD) specifically.

Consumption of whole fruits increases the risk of type 2 diabetes.

Taxation of sugar-sweetened beverages reduced the incidence rate of type II diabetes in India.

Medications to treat obesity have unwanted side effects.

LDL cholesterol has a causal role in the development of cardiovascular disease.

Medications to treat obesity do not have side effects.

In young and middle-aged adults, current or remote uses of ADHD medications increase the risk of serious cardiovascular events.

Medications to treat obesity are highly effective.

Autophagy deficiency in the liver increases vulnerability to insulin resistance.


Monoclonal antibody targeting of N-cadherin encourages castration resistance.

Reducing H3k4me3 methylation induces mouse epiblast stem cells to naive pluripotency efficiently.

Ca2+ cycling is a UCP1-dependent thermogenic mechanism.

Dscam1 acts as a hypervariable pattern-recognition receptor for the immune system.

Tirasemtiv has no effect on cardiac muscle.

Traditional reviews are biased in their interpretations.

Fibroblast growth factor 21 protects against atherosclerosis by modulating adiponectin and SREBP2 levels.

IgA plasma cells that are specific for transglutaminase 2 are scarce in the duodenal mucosa of celiac disease patients when the disease is active.

Lack of FGF21 in mice increases life expectancy.

β-sheet opening occurs during pleurotolysin pore formation.

Monoclonal antibody targeting of N-cadherin inhibits castration resistance.

Monoclonal antibody targeting of N-cadherin encourages metastasis.

Monoclonal antibody targeting of N-cadherin inhibits growth.

Sildenafil worsens erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.

A breast cancer patient's capacity to metabolize tamoxifen influences treatment outcome.

Nonsteroidal antinflammatory drugs are ineffective as cancer treatments.

Nonsteroidal antinflammatory drugs show potential anticancer indications.

Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission.

Pioglitazone use is not associated with an increased risk of prostate cancer.


Monoclonal antibody targeting of N-cadherin encourages metastasis.

JMJD6 slows the hydroxylation of C-terminal lysine

Origin gross domestic product(GDP) is negatively related to dengue virus (DENV-1) diffusion in air traffic shipments.

RA activation of DIF2 and NB4 cells induces hallmarks of transcriptionally active promoters.

Reduced phosphorylation of PP2A increases HDAC4 dephosphorylation by enhancing PP2A-HDAC4 interaction.

Albendazole is used to treat soil-transmitted helminths.

Specialized functional cell types can be derived from human pluripotent stem cells.

Increased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm.

Klf4 is important for proper myeloid cell differentiation.

Transcription rates in S. cerevisiae range between 0.7 and 2 kb/min.

Active caspase-11 participate in regulating phagosome-lysosome fusion.

Side effects associated with antidepressants increases risk of stroke.

The relationship between a breast cancer patient's capacity to metabolize tamoxifen and treatment outcome is independent of the patient's genetic make-up.


Monoclonal antibody targeting of N-cadherin inhibits castration resistance.

Cancer-associated fibroblasts (CAFs) have no known interaction with cancer cells in the formation and activation of CAFs.

HOXB4 facilitates HSC expansion when co-cultured with HSCs.

There is no association between HNF4A mutations and diabetes risks.

50% of patients exposed to radiation have activated markers of mesenchymal stem cells.

Splenomegaly is observed in knockin mouse lacking the SHP-2 MAPK pathway.

For every 1,000 children with cerebral palsy, more than 300 of them are premature or underweight at birth.

Folate and vitamin B12 levels influence the association between homocysteine and preeclampsia.

The NF-κB essential modulator gene prevents intestinal inflammation by inhibiting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death.

A T helper 2 cell (Th2) environment impedes disease development in patients with systemic lupus erythematosus (SLE).

BLM gene encodes RecQ-class DNA helicase.

Retinoic acid receptor-related orphan receptor gamma (RORγ) is a therapeutic target for castration-resistant prostate cancer (CRPC)


Monoclonal antibody targeting of N-cadherin inhibits growth.

Over half of the gabonese children with Schimmelpenning-Feuerstein-Mims syndrome (SFM) had a plasma lactate of more than 5mmol/L.

MafA ubiquitination increases the recruitment of coavtivator P/CAF by MafA.

Nonsteroidal antinflammatory drugs show potential anticancer indications.

Stacking is more stable when a purine is present in the +5 position (C1698).

Early patent ductus ateriosus (PDA) screening increases in-hospital mortality.

Ca2+ cycling is a UCP1-independent thermogenic mechanism.

Genetic deficiency of mast cells leads to decreased weight gain in a mouse model of diet-induced obesity.

Upon developing tyrosine-kinase inhibitor resistance, new mutations in epidermal growth factor receptors emerge and cause treatment failure.

N348I mutations reduce resistance to nevirapine.


Most termination events in Okazaki fragments are dictated by initiation patterns.

Antimicrobial agents are less effective due to the pressure of antimicrobial usage.

Surgical treatment is not superior to non-surgical in treating adults with displaced fractures of the proximal humerus.

A mutation in HNF4A leads to an increased risk of developing diabetes by the age of 14 years.

The recruitment of Wdr5 to its target loci depends on Kat8.

G-CSF increases the expansion and infiltration of MDSCs into tumors.

Ultrasound guidance significantly reduces the number of needle insertion attempts necessary for a given procedure.

The density of cytokine receptor bearing cells affects the distance over which cytokines act.

In breast cancer, the loss of myoepithelial cells promotes the transition of ductal carcinoma in situ to invasive carcinoma.

Alteration of origin firing causes changes in termination zones of Okazaki fragments.

Recognition of start codons depends on the translation initiation factor IF3.

Understanding epigenetic regulation of replication is essential for the reational design of episomally replicating vectors.

Pseudoknots are not evolutionarily conserved in most eukaryotes.

The number of unfertilized oocytes in mated hermaphrodites increases with age.

mcm 5 s 2 U is required for proper decoding of NNR codons in eukaryotes.

During non-homologous end joining, the ligation step is not as tolerant of disrepairs and other distortions when joining 5' of strand breaks as compared to 3' strand breaks.

During non-homologous end joining, the ligation step is not as tolerant of disrepairs and other distortions when joining 3' of strand breaks as compared to 5' strand breaks.

Cellular differentiation of embryonic stem cells is accompanied by changes in replication timing, transcription and nuclear localization.


Mouse models can be generated using "artificial spermatids."

The repeat-variable diresidue (RVD) in the loop of Transcription-Activator Like (TAL) effectors specifies the nucleotides-amino acid contact at the target promoter element.

Homozygous deletion of murine Sbds gene from osterix-expressing mesenchymal stem and progenitor cells (MPCs) induces oxidative stress.

Oxidative DNA damage inhibits STING signalling.

Type 1 Diabetes is associated with subtle perturbations in T reg development.

Glycan adaptation is rarely observed in the B-cell repertoire.

There is a positive correlation between hip fractures and statin use.

Most termination events in Okazaki fragments are dictated by initiation patterns.

Natriuretic peptides protect against diabetes.

The predominant localization of Linc00173 is in mononuclear macrophage nuclei.

Lack of FGF21 in mice increases life expectancy.

Androgenetic haploid mouse embryonic stem cells (ESCs) can be derived and genetically manipulated in vitro.

In pediatric tissue, most T cells are naive T cell emigrants from the thymus.

Human embryonic stem cells have the capacity to give rise to differentiated progeny representative of all three embryonic germ layers.

Specialized functional cell types can be derived from human pluripotent stem cells.

Transplanted human glial progenitor cells can mature in their host animal.

Human embryonic stem cells give rise to cell types from all three embryonic germ layers.

Human embryonic stem cells give rise to cell types from the outer embryonic germ layer, but not the other two layers.

De novo assembly of sequence data has fewer specific contigs than unassembled sequence data.


Mutant mice lacking SVCT2 have severely reduced ascorbic acid levels in both brain and adrenals.

The PPR MDA5 has twenty N-terminal CARD domains.

Reducing H3k4me3 methylation induces mouse epiblast stem cells to naive pluripotency efficiently.

Major vault protein (MVP) leads to more aggressive tumors by regulating the sorting of tumor suppressive miR-193a into extracellular vesicles (EVs).

Citrullinated proteins externalized in neutrophil extracellular traps act indirectly to disrupt the inflammatory cycle.

Primary pro-inflammatory cytokines suppress secondary pro- and anti-inflammatory mediators.

FACT and other histone chaperone(s) compensate for Histone 2A (H2A)-histone 2B (H2B) dimer eviction during the histone exchange process.

Tonic signaling from the scFv prevents constitutive stimulation.

The DdrB protein from Deinococcus radiodurans functions as a pentamer.

The number of unfertilized oocytes in mated hermaphrodites increases with age.

A 100g dose of chloroquine chemoprophylactic regimen results in retinal toxicity after 5-6 years of weekly intake.

Mice lacking Sirt1 in Sf1-expressing neurons have increased susceptibility to diet-induced obesity and insulin resistance.

Mice lacking Sirt1 in Sf1-expressing neurons are immune to diet-induced obesity and insulin resistance.

Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes fibrosis.

A deficiency of vitamin B12 decreases blood levels of homocysteine.

A deficiency of folate increases blood levels of homocysteine.

Lack of FGF21 in mice slows the rate of atherosclerotic plaque formation.

Reduced levels of lipolysis leads to higher P38 phosphorylation in adipose tissue.

Lack of FGF21 in mice leads to atherosclerotic plaque formation.

A deficiency of vitamin B6 decreases blood levels of homocysteine.


Mutations in G-Beta protein GNB1 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.

The M2-phenotype in brown adipose tissue macrophages increases brown adipose tissue thermogenic activity.

Transcription factor EB induces transcription of pro-inflammatory cytokines in macrophages infected with Staphylococcus aureus.

TNFAIP3 is a glioblastoma tumor suppressor.

Piezo1 channels are sensors for cell migration in epithelial cells.

Gastric infection with Helicobacter pylori decreases risk of gastric cancer in humans.

A mutation in HNF4A leads to an increased risk of diabetes by the age of 14 years.

Peroxynitrite is required for induction of T cell tolerance.

MeCP2 influences the synaptic maturation of neurons.

Hematopoietic Stem Cell purification reaches purity rates above 90%.

Intra-cerebroventricular infusion of amyloid-β oligomers reduces expression of fibronectin type-III domain-containing protein 5 mRNA in mice hippocampi.

ScPif1p has reduced binding ability to G-rich ssDNA compared to non-G-rich ssDNA.

The deamination of cytidine to uridine on the minus strand of viral DNA can inactivate the viral genome by inducing G-to-A mutations.

ScPif1p has higher binding ability to G-rich ssDNA than to non-G-rich ssDNA.

The minor G allele of FOXO3 downregulates pro-inflammatory cytokines.

The minor G allele of FOXO3 is related to less severe symptoms of Crohn's Disease.

MUC1-C activates the NF-κB p65 signaling pathway by interacting with IκB kinase ß.

In patients with congenital heart defects, β-blockers significantly improve clinical heart failure outcomes.

Glioblastoma multiforme (GBM) is characterized by extensive invasion, rapid growth, necrosis, and angiogenesis.


Mutations in RIM1 decrease levels of IME1 RNA.

p75 NTR - associated cell death executor (NADE) interacts with the p75 NTR death domain

Replacement of OCT4 and SOX2 genes with GATA3 has the ability to reprogram human cells.

The tip of the inner tube of the toxic type VI secretion system (T6SS) antibacterial effector in Escherichia coli (E. coli) is decorated with VgrG and PAAR proteins.

Pioglitazone use is significantly associated with an increased risk of pancreatic cancer.

Bone marrow cells don't contribute to adult macrophage compartments.

In rhesus macaques, daily subcutaneous injections of tenofovir protects against rectally transmitted simian-human immunodeficiency virus.

miR-142-5P is a temperature-sensitive microRNA (miRNA).

Osteocytes have an essential role in G-CSF induced HSPC mobilization.

Patients with microcytosis and higher erythrocyte count were more resistant to severe malarial anaemia when infected with Plasmodium falciparum.

HSCT-T dosage may not be diagnostic if the onset of symptoms occurs less than 3 hours before AMI.

Mutations in RIM1 raise levels of IME1 RNA.

The PPR MDA5 has twenty N-terminal CARD domains.

IFIT1 speeds viral replication by allowing for the proliferation of mis-capped viral RNAs.

LSD1-positive promoters are associated with RNA polymerase II

p16INK4A degradation is  linked to an abnormal wound response caused by the microinvasive step of advanced Oral Potentially Malignant Lesions (OPMLs).

RAD52 is involved in break-induced DNA replication (BIR).

Emodin forms hydrogen bonds with residues involved in PGAM1 substrate binding.

mcm 5 s 2 U is required for proper decoding of NNR codons in eukaryotes.

MafA phosphorylation enhances its ubiquitination.


Mutations in RIM1 raise levels of IME1 RNA.

Retinoic acid receptor-related orphan receptor gamma (RORγ) is a therapeutic target for castration-resistant prostate cancer (CRPC)

Gastric infection with Helicobacter pylori increases risk of gastric cancer in humans.

Medications to treat obesity are highly effective.

Foxp3 represses the expression of transcriptional regulators implicated in memory T cell development.

LDL cholesterol has a causal role in the development of cardiovascular disease.

Microcin J25 inhibits nucleoside triphosphate (NTP) binding.

Pro-inflammatory cytokines are up repressed during tumor development.

Ca2+ cycling is a UCP1-dependent thermogenic mechanism.

Reducing H3k4me3 methylation induces mouse epiblast stem cells to naive pluripotency efficiently.


Myelin sheaths are lipid-rich cellular structures.

Genes involved in pre-mRNA splicing have a significant impact on genome stability.

T cell receptor /CD3 microdomains are required to induce the immunologic synapse.

Oat tolerant coeliac patients may have oat specific inflammatory cells in their small bowel mucosa.

Trans-acting factors, such as lncRNAs, influence mRNA translation.

Splenomegaly is observed in knockin mouse lacking the SHP-2 MAPK pathway.

The one-child policy has created a hospitable environment for female infants.

There is no known interaction between Pioneer factor OCT3/4 and major chromatin remodeling factors.

Rhythmic expression of Cry1 translates directly into a circadian regulation of cAMP signaling in gluconeogenesis.

MICAL redox enzymes regulate actin dynamics.

Myelin sheaths play a role in action potential propagation.

Lamins are found within the inner layer of the nuclear membrane of all cells.

Lamins are found within the inner layer of the mitochondrial membrane of all cells.

Lamins are associated with nuclear membrane structure maintenance.

Lamins have no effect on nuclear membrane structure maintenance.

Cancer-associated fibroblasts (CAFs) are constituents of tumor microenvironments

Cancer-associated fibroblasts (CAFs) interact with cancer cells to mediate formation and activation of CAFs.

The microtubule-dependent delivery and secretion of matrix metalloproteases (MMPs) is partially responsible for the disassembly of adhesion sites.

0-dimensional biomaterials lack inductive properties.


Myelin sheaths play a role in action potential propagation.

aPKCz causes tumour suppression by affecting glutamine metabolism.

Reduction of purity of cytoplasmic membranes isolated from overexpressors is indicated by stronger spots for OmpA in 2D BN-PAGE gels.

Cytochrome c is transferred from cytosol to the mitochondrial intermembrane space during apoptosis.

Increased mobility of retrotransposons does not lead to mutation and higher tumorigenesis rates.

CDK6 shows impaired binding to loss-of-function variants of p18 INK4C.

Sympathetic nerve activity is elevated throughout normal pregnancy.

The proportion of people with visual difficulty is two times higher in low-income countries than in high-income countries.

The DEXI promoter region is bound by multiple transcription factors in a murine haematopoietic progenitor cell line.

Understanding epigenetic regulation of replication is essential for the reational design of episomally replicating vectors.

Certain immunomodulator-human dialyzable leukocyte extract (hDLE) peptides are recognized by toll-like receptors (TLRs) on macrophages and dendritic cells.

Inhibiting focal adhesion formation enables cells to convert mechanical strain into eventual scarring.

Binding of p53 to enhancer regions (p53BERs) regulates the activity of p53 transcription and cell cycle arrest through the production of p53-dependent eRNAs.

Inhibiting focal adhesion formation increases the rate at which cells convert mechanical strain into inflammation and fibrosis.

EGR2 is important to myelination of the peripheral nervous system.


N348I mutations cause resistance to nevirapine.

GATA3 regulates self-renewal capacity in bone marrow hematopoietic stem cells.

The deregulated and prolonged activation of monocytes has deleterious effects in chronic infectious conditions.

The myocardial cell lineage originally develops from cardiac progenitors of exclusively endodermal origin.

Albendazole is used to treat soil-transmitted helminths.

Epidemiological disease burden from noncommunicable diseases is more prevalent in high economic settings.

miRNAs enforce homeostasis by suppressing low-level ''leaky'' transcription.

Microcin J25 inhibits nucleoside triphosphate (NTP) binding.

Algerian physicians constitue the largest component of sub-Saharan Africa-trained physicians in the United States.

High levels of CRP lead to a higher risk of exacerbations in chronic obstructive pulmonary disease (COPD).

N348I mutations reduce resistance to nevirapine.

Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission.

R2D2 stops miRNA production by increasing the selectivity of Dcr2 for long dsRNA.

The deamination of cytidine to uridine on the minus strand of viral DNA can inactivate the viral genome by inducing G-to-A mutations.

Carriers of HNF4A mutations are at reduced risk for diabetes.

HNF4A mutations are associated with macrosomia in infancy.

Monoclonal antibody targeting of N-cadherin encourages metastasis.

There is no association between HNF4A mutations and diabetes risks.

The PPR MDA5 has twenty N-terminal CARD domains.


N348I mutations reduce resistance to nevirapine.

In breast cancer, the loss of myoepithelial cells slows the transition of ductal carcinoma in situ to invasive carcinoma.

Pyridostatin stabilizes the G - quadruplex in the telomeric region.

RA activation of DIF2 and NB4 cells induces hallmarks of transcriptionally active promoters.

Human embryonic stem cells have the capacity to give rise to differentiated progeny representative of all three embryonic germ layers.

De novo assembly of sequence data has fewer specific contigs than unassembled sequence data.

Transcription factor EB induces transcription of pro-inflammatory cytokines in macrophages infected with Staphylococcus aureus.

PrimPol generates short DNA replication intermediates on the leading strand during DNA replication.

Diabetes remission occurs more in people treated with conventional therapy than in people treated with laparoscopic adjustable gastric banding surgery.

cSMAC formation represses weak ligand signalling.

Origin gross domestic product(GDP) is positively related to dengue virus (DENV-1) diffusion in air traffic shipments.

Monoclonal antibody targeting of N-cadherin inhibits growth.


NAC destabilizes NO to increase the effect of contrast agents on renal functions.

The DESMOND program demonstrates no significant impact on biochemical outcomes.

The minor G allele of FOXO3 downregulates pro-inflammatory cytokines.

Genes regulated by Esrrb transcription factor are sensitive to Mbd3 function.

The innate immune response struggles to remove small numbers of parasites.

Microglia are an innate immune cell type of the peripheral nervous system.

Lack of FGF21 in mice slows the rate of atherosclerotic plaque formation.

The peak incidence of fractures occurs in toddlers.

Persister cells provide relapse resistance in cancer patients.

High levels of CRP lead to a higher risk of exacerbations in chronic obstructive pulmonary disease (COPD).

Citrullinated proteins externalized in neutrophil extracellular traps act indirectly to perpetuate the inflammatory cycle via induction of autoantibodies.

Angiotensin converting enzyme inhibitors are associated with decreased risk for functional renal insufficiency.

The effect of Lipopolysaccharides on kidney barrier function is dependent on inflammation levels.

NAC inhibits the generation of angiotensin-converting enzyme.

Lipopolysaccharides have an inflammation independent effect on kidney barrier function.

40mg/day dosage of folic acid and 2mg/day dosage of vitamin B12 does not affect chronic kidney disease (CKD) progression.

Reduced phosphorylation of PP2A increases HDAC4 dephosphorylation by enhancing PP2A-HDAC4 interaction.

Reduced phosphorylation of PP2A suppresses HDAC4 dephosphorylation.

Systemic immunosuppressive (IS) therapy does not enhance the chance of cancer mortality in patients with inflammatory eye disease (IED)

32% of liver transplantation programs required patients to discontinue methadone treatment in 2001.


NAC inhibits the generation of angiotensin-converting enzyme.

Lipopolysaccharides have an inflammation independent effect on kidney barrier function.

Propriospinal interneurons that play a role in the plastic reorganization of spinal circuits are integral for recovery from spinal cord injury.

Forkhead 0 (fox0) transcription factors are involved in apoptosis.

DRD1 proteins enable Pol V transcription in vivo.

Replacement of OCT4 and SOX2 genes with GATA3 has the ability to reprogram human cells.

Localization of PIN1 in the roots of Arabidopsis requires VPS9a

Mice lacking Sirt1 in Sf1-expressing neurons have increased susceptibility to diet-induced obesity and insulin resistance.

A low percentage of hematopoietic progenitor cells are susceptible to HIV-1 infection ex vivo.

Antimicrobial agents are less effective due to the pressure of antimicrobial usage.

Side effects associated with antidepressants lower risk of myocardial infarction.

AMP-activated protein kinase (AMPK) activation reduces inflammation-related fibrosis in the lungs.

Depletion of nitric oxide is responsible for vasospasm.

The cytokine receptor which regulates chemotaxis and formation of lymph nodes is involved in production of myeloperoxidase in the left atrium.

Inhibiting glucose-6-phospate dehydrogenase improves lipogenesis by deactivating LKB1-AMPK signaling.

Chenodeoxycholic acid treatment increases brown adipose tissue activity.


NR5A2 does not play a role in development of endometrial tissues.

Bariatric surgery leads to positive outcomes in mental health.

Foxk2 regulates autophagy genes in muscle cells and fibroblast cells.

PGE 2 suppresss intestinal tumor growth by altering the expression of tumor suppressing and DNA repair genes.

Environmental factors can influence the development of breast cancer.

Intra-cerebroventricular infusion of amyloid-β oligomers reduces expression of fibronectin type-III domain-containing protein 5 mRNA in mice hippocampi.

Incidence of 10/66 dementia is lower than the incidence of DSM-IV dementia.

Normal expression of RUNX1 causes tumorsupressing effects.

siRNA knockdown of A20 accelerates tumor progression in an in vivo murine xenograft model.

RANK-RANKL pathway signalling is linked to development of Aire-expressing medullary thymic epithelial cells.

Decreased conversion of PGE 2 to PPARy ligand 15-ket-PGE 2 causes accumulation of PGE.

NR5A2 is important in reverse cholesterol transport in humans.

EGR2 is important to myelination of the peripheral nervous system.

HAND2 methylation is a key step in early endometrial carcinogenesis.

Deregulation of HAND2 is a crucial step in endometrial carcinogenesis in mice.

Activated Cdk5 regulates DNA damage-induced neuronal death.

ALDH1 expression is associated with poorer prognosis for breast cancer primary tumors.

p16INK4A degradation is encoded by CDKN2A.

eRNAs influence is linked to senescence, aging, and carcinogenesis.

Activation of PPM1D enhances p53 function.


NR5A2 is important in reverse cholesterol transport in humans.

Dscam1 acts as a hypervariable pattern-recognition receptor for the immune system.

Bariatric surgery leads to negative outcomes in mental health.

AMP-activated protein kinase (AMPK) activation reduces inflammation-related fibrosis in the lungs.

Noninvasive positive pressure ventilation is not predictive of acute respiratory failure after solid organ transplantation.

Reduced responsiveness to interleukin-2 in regulatory T cells is associated with autoimmune diseases such as Type 1 Diabetes.

Hematopoietic Stem Cell purification reaches purity rates above 90%.

Risedronate increases risk of vertebral and non-vertebral fractures.

Walking in traffic areas in London improves lung function in elderly adults.

The Snf1 complex regulates carbon and energy metabolism in baker's yeast (Saccharomyces cerevisiae).

LDL cholesterol has a causal role in the development of cardiovascular disease.

Increased lipolysis leads to higher P38 phosphorylation in adipose tissue.

Reduced levels of lipolysis leads to higher P38 phosphorylation in adipose tissue.

GATA3 regulates self-renewal capacity in bone marrow hematopoietic stem cells.

GATA3 regulates cell cycle progression in bone marrow hematopoietic stem cells.

Activated Cdk5 phosphorylates the ATM protein in response to DNA damage.


Natriuretic peptides increase susceptibility to diabetes.

B3-Galectin decreases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR.

90% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.

Lamins are associated with nuclear membrane structure maintenance.

Cellular differentiation of embryonic stem cells is accompanied by changes in replication timing, transcription and nuclear localization.

MFGE8 regulates fat absorption by binding to av-Beta3 and av-Beta5 integrins.

Cancer-associated fibroblasts (CAFs) interact with cancer cells to mediate formation and activation of CAFs.

Gastric lavage is an effective treatment for acute paraquat poisoning.

Decrease of p62 in prostate tumor stroma results in defective autophagy.

Active caspase-11 participate in regulating phagosome-lysosome fusion.

Human embryonic stem cells give rise to cell types from all three embryonic germ layers.

Natriuretic peptides protect against diabetes.

Medications to treat obesity have unwanted side effects.

Long chain polyunsaturated fatty acids supplementation reduces wheezing and asthma.

Type 1 Diabetes is associated with subtle perturbations in T reg development.

Omnivores produce less trimethylamine N-oxide from dietary I-carnitine than vegans.

Medications to treat obesity do not have side effects.

Medications to treat obesity are highly effective.

Omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegans.

Autophagy deficiency in the liver increases vulnerability to insulin resistance.


Natriuretic peptides protect against diabetes.

Taxation of sugar-sweetened beverages reduced the incidence rate of type II diabetes in India.

The RANK-RANK-Ligand (RANKL) pathway is involved in the development of Aire-expressing medullary thymic epithelial cells (mTECs).

Lysine histone demethylase inhibitor JIB 04 is inactive against KDM5A.

Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 inhibit West Nile virus replication in cortical neurons.

Approximately 250,000 people are infected with human T-cell lymphotropic virus type 1 in the United Kingdom.

Improvements in OER catalysts show stable activity over several hundred hours.

Intra-cerebroventricular infusion of amyloid-β oligomers reduces expression of fibronectin type-III domain-containing protein 5 mRNA in mice hippocampi.

BiP is a general endoplasmic reticulum stress marker.

Deltex interacts with eIF3. There is no known interaction between Deltex and elF3

Long chain polyunsaturated fatty acids supplementation has no significant effects on wheezing or asthma at 3 and 6 years.

Peroxynitrite is required for induction of T cell tolerance.

Prescribed exercise training improves quality of life.

Diabetes remission occurs more in people treated with conventional therapy than in people treated with laparoscopic adjustable gastric banding surgery.


Neutrophil extracellular trap (NET) antigens may contain the targeted autoantigens PR3 and MPO.

RANK-RANKL pathway signalling is linked to development of Aire-expressing medullary thymic epithelial cells.

p16INK4A degradation is  linked to an abnormal wound response caused by the microinvasive step of advanced Oral Potentially Malignant Lesions (OPMLs).

Vitamin D deficiency effects birth weight.

T cell receptor /CD3 microdomains are required to induce the immunologic synapse.

Upon viral challenge, influenza-specific memory CD4+ T cells greatly enhance the early production of inflammatory chemokines in the lung.

Incidence of 10/66 dementia is lower than the incidence of DSM-IV dementia.

Taking anti-depresents is associated with a decrease in the Aβ level in the brain of experimental animals.

Physical activity does not improve cognitive function in individuals with Alzheimers.

A diminished ovarian reserve is a very strong indicator of infertility, even in an a priori non-infertile population.

Gpr124 increases BBB breakdown in mouse models of ischemic stroke.

Many transmembrane receptors transmit signals by long-range conformational changes in the association of alpha-helices across the plasma membrane.

VgrG (Tssl) protein punctures membranes by forming a spike at the tip of the tube apparatus.

Citrullinated proteins externalized in neutrophil extracellular traps act indirectly to disrupt the inflammatory cycle.

Neutrophils produce IL-1β in response to large particles.

Citrullinated proteins externalized in neutrophil extracellular traps act indirectly to perpetuate the inflammatory cycle via induction of autoantibodies.

Ly49Q directs the organization of neutrophil polarization by regulating membrane raft functions.

Intramembrane cleavage by signal peptide peptidase aids in the degradation of proteins with a complex membrane orientation.

The microtubule-dependent delivery and secretion of matrix metalloproteases (MMPs) is partially responsible for the disassembly of adhesion sites.

Major antigen-induced signals from the T cell receptor and secondary signals from costimulatory receptors are required for T cell activation.


Neutrophils produce IL-1β in response to large particles.

Guanine nucleotide exchange factors (GEFs) mediate RhoA activation in response to tensional forces on fibronectin-binding integrins.

Integrating classroom-based collaborative learning with Web-based collaborative learning offers the best class performance.

Assessing treatment adherence is more beneficial to clinical practice than measuring routine outcomes.

In S. cerevisiae, the absence of RNA surveillance pathways reduces sensitivity to high iron conditions.

There is no known interaction between Pioneer factor OCT3/4 and major chromatin remodeling factors.

Beta-band coherence is diminished for visible stimuli over invisible stimuli.

The DESMOND program demonstrates no significant impact on weight loss.

Pyridostatin stabilizes the G - quadruplex in the telomeric region.

50% of patients exposed to radiation have activated markers of mesenchymal stem cells.

Patients with common epithelial cancers  are more likely to have an emergency event as their first hospital admission if they live in resource-deprived areas.

Basophils promote disease development in patients with systemic lupus erythematosus (SLE).

IL-10 production by monocytes inhibits CD4 + T cell response.

Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 inhibit West Nile virus replication in cortical neurons.

Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 encourage West Nile virus replication in cortical neurons.

PD-1 triggering on monocytes enhances IL-10 production by monocytes.

The deamination of cytidine to uridine on the minus strand of viral DNA can inactivate the viral genome by inducing G-to-A mutations.

Immune complex triggered cell death leads to sequestration of oxidized mitochondrial DNA.


Nigerian physicians constitue the largest component of sub-Saharan Africa-trained physicians in the United States.

EGR2 is important to myelination of the peripheral nervous system.

Blocking the interaction between TDP-43 and respiratory complex I proteins ND3 and ND6 prevents TDP-43-induced neuronal loss.

The effect of Lipopolysaccharides on kidney barrier function is dependent on inflammation levels.

Progerin induces premature aging in stem cells.

There is no increased risk of hypospadias with clomiphene.

Replacement of OCT4 and SOX2 genes with GATA3 has the ability to reprogram human cells.

In breast cancer, the loss of myoepithelial cells promotes the transition of ductal carcinoma in situ to invasive carcinoma.

Reduction of purity of cytoplasmic membranes isolated from overexpressors is indicated by stronger spots for OmpA in 2D BN-PAGE gels.

Risk-adjusted mortality rates are similar in teaching and non-teaching hospitals.

Aggravated inflammation is dependent on NLRP3 inflammasome activation.

Algerian physicians constitue the largest component of sub-Saharan Africa-trained physicians in the United States.

Students who perform poorly in the early years of medical school are less likely to commit professional misconduct later in their careers.

Students who perform poorly in the early years of medical school are at increased risk for professional misconduct later in their careers.

Urbanization is an important risk factor related to the transmission of dengue fever.

Rising temperatures caused by global warming increases risk of dengue fever transmission.

76-85% of people with severe mental disorder receive no treatment in low and middle income countries.

Integrated care is successful at tackling multiple comorbidities.

Rising temperatures caused by global warming lowers the risk of dengue fever transmission.


Nonhuman primates are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.

TNFAIP3 is a glioblastoma tumor enhancer.

Foxp3 enables the expression of transcriptional regulators implicated in memory T cell development.

Systemic immunosuppressive (IS) therapy increases the chance of cancer mortality in patients with inflammatory eye disease (IED)

Noninvasive positive pressure ventilation is not predictive of acute respiratory failure after solid organ transplantation.

The DESMOND program demonstrates no significant impact on lifestyles outcomes.

Myelin sheaths play a role in action potential propagation.

Bone Marrow (BM) transplantation is used to treat acute myeloid leukemia (AML)

Broadly HIV-1 Neutralizing Antibodies (bnAb) 10EB have no affinity for phospholipids.

Medications to treat obesity have unwanted side effects.

Eilat virus (EILV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in nonhuman primates.

Mice are incapable of producing neutralizing antibodies in reponse to the Chikungunya virus (CHIKV) produced in mosquitos.

Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 inhibit West Nile virus replication in cortical neurons.

Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 encourage West Nile virus replication in cortical neurons.

Tuberculosis-induced granulomas express different immune system protein signatures than the surrounding tissue.

Inside the body, falciparum parasites reproduce asexually.

The innate immune response struggles to remove small numbers of parasites.

The latent infection of myeloid cells with human cytomegalovirus induces a number of changes in gene expression.


Nonhypertensive people who are 55 years old have a 90% chance of developing hypertension during their lifetime.

PRC1-bound plasmids sediment at a slower rate in unbound plasmids than in sucrose gradients.

BLM gene encodes RecQ-class DNA helicase.

A 100g dose of chloroquine chemoprophylactic regimen results in retinal toxicity after 5-6 years of weekly intake.

Individuals with Alzheimers who participate in six months of physical activity improve cognitive function for up to 18 months.

MafA ubiquitination decreases the recruitment of coavtivator P/CAF by MafA.

Increase of p62 in prostate tumor stroma results in defective autophagy.

Increased vessel density along with a reduction in fibrosis improves the efficacy of chemotherapy treatments.

Vaccinating the gastrointestinal tract induces protection of rectal and vaginal mucosa.

The Snf1 complex regulates carbon and energy metabolism in baker's yeast (Saccharomyces cerevisiae).

Antimicrobial agents are less effective due to the pressure of antimicrobial usage.

Ambulatory blood pressure monitoring is inaccurate at diagnosing hypertension.

Sudden death can occur in patients with orthostatic hypertension without cardiac conduction abnormalities.

For every 1,000 children with cerebral palsy, more than 300 of them are premature or underweight at birth.

In young and middle-aged adults, current or remote uses of ADHD medications increase the risk of serious cardiovascular events.

Diabetes remission occurs less in people treated with conventional therapy than in people treated with laparoscopic adjustable gastric banding surgery.

Diabetes remission occurs more in people treated with conventional therapy than in people treated with laparoscopic adjustable gastric banding surgery.

Participants who quit smoking reduce lung cancer risk by approximately 50%.

Decreased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm.

Increased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm.


Noninvasive positive pressure ventilation is not predictive of acute respiratory failure after solid organ transplantation.

Side effects associated with antidepressants do not represent a mortality risk to postmenopausal women.

MafA phosphorylation decreases its ubiquitination.

Traditional reviews are biased in their interpretations.

Consumption of whole fruits increases the risk of type 2 diabetes.

Chenodeoxycholic acid treatment decreases brown adipose tissue activity.

Ribosomal protein (RP) expression is controlled in part by stress-activated regulators.

Integrated care is ineffective at tackling multiple comorbidities.

Foxp3 enables the expression of transcriptional regulators implicated in memory T cell development.

Guanine nucleotide dissociation inhibitor (Rho-GDI) interacts with the p75 NTR death domain

V-9302 inhibits antitumor responses by decreasing cell death and oxidative stress.

Allogeneic mechanical circulatory support is not as effective as autologous mechanical circulatory support for treating acute myocardial infarction.

Sudden death can occur in patients with complex ventricular arrhythmias.

High levels of CRP lead to a higher risk of exacerbations in chronic obstructive pulmonary disease (COPD).

Gastric lavage is an effective treatment for acute paraquat poisoning.

AMP-activated protein kinase (AMPK) activation reduces inflammation-related fibrosis in the lungs.


Nonsteroidal antinflammatory drugs are ineffective as cancer treatments.

Self-advocacy training is effective at decreasing homelessness.

Incidence of sepsis has fallen substantially from 2009 to 2014.

BLM gene encodes RecQ-class DNA helicase.

Replacement of OCT4 and SOX2 genes with GATA3 has the ability to reprogram human cells.

The risk of cancer rises with level of alcohol consumption.

Beta-band coherence is enhanced for visible stimuli over invisible stimuli.

Mutations in G-Beta protein GNB1 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.

Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes fibrosis.

Excess gestational weight gain is associated with obesity-related pregnancy outcomes.

PRC1-bound plasmids sediment at a slower rate in unbound plasmids than in sucrose gradients.

Nonsteroidal antinflammatory drugs show potential anticancer indications.

Side effects associated with antidepressants do not represent a mortality risk to postmenopausal women.

A breast cancer patient's capacity to metabolize tamoxifen influences treatment outcome.

Cancers that initially benefit from epidermal growth factor receptor targeted therapies later become refractory through several mechanisms.

Side effects associated with antidepressants increases risk of stroke.

The relationship between a breast cancer patient's capacity to metabolize tamoxifen and treatment outcome is independent of the patient's genetic make-up.

The most prevalent adverse events to Semaglutide are cardiovascular.

Sildenafil worsens erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.

Monoclonal antibody targeting of N-cadherin encourages metastasis.


Nonsteroidal antinflammatory drugs show potential anticancer indications.

Deletion of ATM and Rad3 related protein is not predictive of acute tissue loss.

Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes epithelial damage.

Students who perform poorly in the early years of medical school are less likely to commit professional misconduct later in their careers.

Active caspase-11 participate in regulating phagosome-lysosome fusion.

Bariatric surgery reduces colorectal cancer.

N348I mutations cause resistance to nevirapine.

Higher plasma levels of I-carnitine, when associated with trimethylamine N-oxide, are negatively correlated with cardiovascular events in humans.

Adult tissue-resident macrophages are seeded before birth.

Side effects associated with antidepressants lower risk of myocardial infarction.

Antidepressants reduce the severity of migraines.

The most prevalent adverse events to Semaglutide are gastrointestinal.

Antidepressants increase the severity of migraines.

Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission.


Normal expression of RUNX1 causes tumorsupressing effects.

Autologous transplantation of mesenchymal stem cells has better graft function than induction therapy with anti-interleukin-2 receptor antibodies.

The G34R/V mutation does not create a hypomethylated phenotype at the H3K36 histone.

Guanine nucleotide exchange factors (GEFs) mediate RhoA activation in response to tensional forces on fibronectin-binding integrins.

90% of patients with melanoma and an objective response to PD-1 blockade will experience a progression in their melanoma.

The proliferative capacity of progenitors is regulated cell-autonomously.

Crossover hot spots are found within gene promoters in Saccharomyces cerevisiae.

The mean suicide rate in women is lower after miscarriage than live birth.

The microtubule-dependent delivery and secretion of matrix metalloproteases (MMPs) is partially responsible for the disassembly of adhesion sites.

In domesticated populations of Saccharomyces cerevisiae, segmental aneuploidy occurs infrequently.

There is a positive correlation between hip fractures and statin use.

ALDH1 expression is associated with poorer prognosis for breast cancer primary tumors.

RUNX1 is downregulated or mutated in TLX1 T-ALL.

Upregulation of PD1 causes the upregulation of Satb1.

Upregulation of PD1 causes the downmodulation of Satb1.

Increase of p62 in prostate tumor stroma results in defective autophagy.

Decrease of p62 in prostate tumor stroma results in defective autophagy.

PD-1 triggering on monocytes enhances IL-10 production by monocytes.

Activation of PPM1D enhances p53 function.


Normal granulomas form in the absence of TNF in Zebrafish.

Pharmacist attendance at ward rounds reduces adverse events in wards.

Cnn1 recruitment varies with cell cycle timing.

Deltex interacts with eIF3. There is no known interaction between Deltex and elF3

Hypocretin neurones suppress panicprone state in rats.

Induced hepatic stem cells possess the potential to differentiate into cholangiocytic cells.

Including pharmacists in rounding teams reduces the incidence of adverse drug events (ADEs).

Pyridostatin stabilizes the G - quadruplex in the telomeric region.

ATM and Rad3 related protein are critical for sensing DNA damage.

Venules have less significant tunica adventitia than arterioles.

Pyridostatin decreases telomere fragility in BRCA2-deficient cells.

Normal granulomas form in the presence of TNF in Zebrafish.

Tuberculosis-induced granulomas express different immune system protein signatures than the surrounding tissue.

The tissue surrounding the granuloma in an immune cell induces an anti-inflammatory immune response.

Neutrophils produce IL-1β in response to large particles.

Mice are incapable of producing neutralizing antibodies in reponse to the Chikungunya virus (CHIKV) produced in mosquitos.

Mice that lack Interferon-γ or its receptor are highly susceptible to experimental autoimmune myocarditis.

The latent infection of myeloid cells with human cytomegalovirus induces a number of changes in gene expression.

Nonhuman primates are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.

Eilat virus (EILV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in nonhuman primates.


Normal granulomas form in the presence of TNF in Zebrafish.

Ribosome-inactivating protein-2 (RIP-2) interacts with the p75 NTR death domain

A 100g dose of chloroquine chemoprophylactic regimen results in retinal toxicity after 5-6 years of weekly intake.

Assessing treatment adherence is more beneficial to clinical practice than measuring routine outcomes.

Activated Cdk5 regulates DNA damage-induced neuronal death.

B3-Galectin increases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR.

Vitamin D deficiency effects birth weight.

Replacement of histone H2A with H2A.Z accelerates gene activation in yeasts by destabilizing +1 nucleosomes.

Lipopolysaccharides have an inflammation independent effect on kidney barrier function.

Lice attenuated SIV vaccines induce a stronger antigen-specific T cell response in lymph node cells.


Notch signaling occurs between tumor cells and stromal cells.

Physical activity level has no association with the difference in maximal oxygen consumption between black and white youth.

7-day-old adult Caenorhabditis elegans exhibit approximately 5% of the learning capacity seen in 1-day old adults.

Tirasemtiv has no effect on cardiac muscle.

CD44v6 is not associated with constitutive and reprogrammed cancer stem cells driving cancer metastasis.

Less than 10% of patients exposed to radiation have activated markers of mesenchymal stem cells.

Female carriers of the Apolipoprotein E4 (APOE4) allele have increased risk for Alzheimer's disease.

HNF4A mutations are associated with macrosomia in infancy.

B cells go though plasmablast differentiation and antibody production by continuous expression of EBI2.

H4 G94P proteins inhibit chromatin assembly, which decreases free histones.

Pediatric SCD patients with vaso-occlusive crisis show increased morphine use after breathing 80 ppm iNO for 4 hours.

Tumor development occurs in conjunction with upregulation of pro-inflammatory cytokines.

Pro-inflammatory cytokines are up regulated during tumor development.

Tumor development occurs in conjunction with suppression of pro-inflammatory cytokines.

Cancer-associated fibroblasts (CAFs) interact with cancer cells to mediate formation and activation of CAFs.

ALDH1 expression is associated with poorer prognosis for breast cancer primary tumors.

Pro-inflammatory cytokines are up repressed during tumor development.

In breast cancer, the loss of myoepithelial cells promotes the transition of ductal carcinoma in situ to invasive carcinoma.

Cancer-associated fibroblasts (CAFs) have no known interaction with cancer cells in the formation and activation of CAFs.

Myelin sheaths play a role in action potential propagation.


Nuclear transfer from adult human fibroblasts to human oocytes can give rise to blastocysts containing expandable pluripotent cells.

Pyridostatin stabilizes the G - quadruplex in the telomeric region.

32% of liver transplantation programs required patients to discontinue methadone treatment in 2001.

The innate immune response struggles to remove small numbers of parasites.

Cytosolic proteins bind to iron-responsive elements on mRNAs coding for TFRC1.

AZT given with ribavirin increases anemia.

CRP is positively correlated with postoperative mortality following Coronary Artery Bypass Graft (CABG) surgery.

Distant CREs are less conserved among species.

Replacement of OCT4 and SOX2 genes with GATA3 has the ability to reprogram human cells.

Beta-band coherence is enhanced for visible stimuli over invisible stimuli.

There is no increased risk of hypospadias with clomiphene.

Human embryonic stem cells give rise to cell types from the outer embryonic germ layer, but not the other two layers.

Cellular differentiation of embryonic stem cells is accompanied by changes in replication timing, transcription and nuclear localization.

Human embryonic stem cells have the capacity to give rise to differentiated progeny representative of all three embryonic germ layers.

Mitochondria play a major role in energy production.

Human embryonic stem cells give rise to cell types from all three embryonic germ layers.

Cancer cells can stimulate the accumulation of intra-tumoural myeloid-derived suppressor cells by promoting granulocyte colony stimulating factor production.

Cardiac tissue-resident macrophages directly contribute to electrical activity.


Oat tolerant coeliac patients may have oat specific inflammatory cells in their small bowel mucosa.

YAP/TAZ is required in intestinal regeneration in mouse models of ulcerative colitis.

L3MBTL2 binds to H2AK119Ub marked chromatin to form a PRC1 complex.

Bacteriophagaes MS2 and Qβ are members of the Leviviridae.

Retinoic acid receptor-related orphan receptor gamma (RORγ) is a therapeutic target for castration-resistant prostate cancer (CRPC)

ART has no effect on the infectiveness of HIV-positive people.

Incidence of heart failure increased by 10% in women since 1979.

0-dimensional biomaterials lack inductive properties.

The most prevalent adverse events to Semaglutide are cardiovascular.

Pyridostatin reduces proliferation of homologous recombination - defective cells.

Chlamydia trachomatis is most prevalent in the UK among sexually-experienced individuals aged 16 to 24.

Vaccinating the gastrointestinal tract induces protection of rectal and vaginal mucosa.

Systemic immunosuppressive (IS) therapy increases the chance of cancer mortality in patients with inflammatory eye disease (IED)

Systemic immunosuppressive (IS) therapy does not enhance the chance of cancer mortality in patients with inflammatory eye disease (IED)

Bacterial meningitis can be diagnosed on the basis of positive cerebrospinal fluid (CSF) cultures.

Gastric infection with Helicobacter pylori increases risk of gastric cancer in humans.

Gastric infection with Helicobacter pylori decreases risk of gastric cancer in humans.

The most prevalent adverse events to Semaglutide are gastrointestinal.

The effect of Lipopolysaccharides on kidney barrier function is dependent on inflammation levels.

In rhesus macaques, daily subcutaneous injections of emtricitabine are ineffective at protecting against rectally transmitted simian-human immunodeficiency virus.


Physical activity level is associated with the difference in maximal oxygen consumption between black and white youth.

Primary cervical cancer screening with HPV detection has lower longitudinal sensitivity than conventional cytology to detect cervical intraepithelial neoplasia grade 2.

Overexpressing Cnp1 N-tail variants exacerbates the temperature-sensitive growth defect of scm3-139.

Lack of FGF21 in mice leads to reduced lifespan.

Deletion of ATM and Rad3 related protein leads to acute tissue loss.

Oxidative phosphorylation is one of the primary glycometabolic pathways in cells.

Sudden death can occur in patients with complex ventricular arrhythmias.

p75 NTR - associated cell death executor (NADE) interacts with the p75 NTR death domain

Decreased conversion of PGE 2 to PPARy ligand 15-ket-PGE 2 causes accumulation of PGE.

Exercise reduces cancer mortality rates among Chinese citizens.

Exercise increases cancer mortality rates among Chinese citizens.

Suboptimal nutrition is a leading cause of premature death

Excess gestational weight gain is associated with obesity-related pregnancy outcomes.

Vitamin D deficiency effects birth weight.

Medications to treat obesity are highly effective.

Insulin decreases risk of severe kidney failure.

Autophagy deficiency in the liver increases vulnerability to insulin resistance.


Microcin J25 encourages nucleoside triphosphate (NTP) binding.

Deletion of ATM and Rad3 related protein is not predictive of acute tissue loss.

Pseudogene PTENP1 encodes a transcript that regulates PTEN expression.

Binding of p53 to enhancer regions (p53BERs) regulates the activity of p53 transcription and cell cycle arrest through the production of p53-dependent eRNAs.

Neutrophil extracellular trap (NET) antigens may contain the targeted autoantigens PR3 and MPO.

AZT given with ribavirin increases anemia.

Neutrophils produce IL-1β in response to large particles.

Eliminating the last sporadic cases of malaria requires considerable funding.

Exhaustion of B cells contributes to poor Ab response in HIV-infected individuals.

Prescribed exercise training improves quality of life.

Medications to treat obesity have unwanted side effects.

Medications to treat obesity do not have side effects.