The deamination of cytidine to uridine on the minus strand of viral DNA can inactivate the viral genome by inducing G-to-A mutations.

Scapular stabilizer exercises are more effective than general exercise therapy in reducing pain and improving function of the shoulder.

Deletion of ATM and Rad3 related protein is not predictive of acute tissue loss.

Reduced responsiveness to interleukin-2 in regulatory T cells is associated with autoimmune diseases such as Type 1 Diabetes.

IgA plasma cells that are specific for transglutaminase 2 are scarce in the duodenal mucosa of celiac disease patients when the disease is active.

The combination of physical examinations with C-reactive protein values do not improve the accuracy of radiographic verified pneumonia predictions.

Tonic signaling from the scFv induces constitutive stimulation.

Normal granulomas form in the presence of TNF in Zebrafish.

RA activation of DIF2 and NB4 cells induces hallmarks of transcriptionally active promoters.

Gpr124 increases BBB breakdown in mouse models of ischemic stroke.

Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 inhibit West Nile virus replication in cortical neurons.

Immune complex triggered cell death leads to sequestration of oxidized mitochondrial DNA.

Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 encourage West Nile virus replication in cortical neurons.

Cytochrome c is transferred from cytosol to the mitochondrial intermembrane space during apoptosis.

Formation of N-terminal pyroglutamate by glutamine cyclase (GC) competes with NTAQ1 for Nt-Gln substrates.

Glycan adaptation involves insertion-deletion events.

ScPif1p has higher binding ability to G-rich ssDNA than to non-G-rich ssDNA.

ScPif1p has reduced binding ability to G-rich ssDNA compared to non-G-rich ssDNA.


The density of cytokine receptor bearing cells affects the distance over which cytokines act.

miRNAs enforce homeostasis by suppressing low-level ''leaky'' transcription.

Increased microtubule acetylation exacerbates LRRK2 Roc-COR domain mutation induced locomotor deficits.

p75 NTR - associated cell death executor (NADE) interacts with the p75 NTR death domain

Combination nicotine replacement therapies with varenicline or bupropion are more effective after 12 weeks of reatment compared to varenicline monotherapy.

Major vault protein (MVP) leads to more aggressive tumors by regulating the sorting of tumor suppressive miR-193a into extracellular vesicles (EVs).

Mutations in G-Beta protein GNB1 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.

Nonhypertensive people who are 55 years old have a 90% chance of developing hypertension during their lifetime.

Gastric lavage is an effective treatment for acute paraquat poisoning.

Ambulatory blood pressure monitoring is inaccurate at diagnosing hypertension.

Type 1 Diabetes is associated with subtle perturbations in T reg development.

The density of cytokine receptor bearing cells has no effect on the distance over which cytokines act.

Primary pro-inflammatory cytokines suppress secondary pro- and anti-inflammatory mediators.

Major antigen-induced signals from the T cell receptor and secondary signals from costimulatory receptors are required for T cell activation.

Many transmembrane receptors transmit signals by long-range conformational changes in the association of alpha-helices across the plasma membrane.

T cell receptor /CD3 microdomains are required to induce the immunologic synapse.

The cytokine receptor which regulates chemotaxis and formation of lymph nodes is involved in production of myeloperoxidase in the left atrium.

Pro-inflammatory cytokines are up regulated during tumor development.

The effect of Lipopolysaccharides on kidney barrier function is dependent on inflammation levels.

Many cytokines that are produced by cancer cells also contribute to carcinogenesis.


The density of cytokine receptor bearing cells has no effect on the distance over which cytokines act.

Having a main partner worsens HIV outcomes.

Energy balance requires hypothalamic glutamate neurotransmission.

NR5A2 is important in reverse cholesterol transport in humans.

Monoclonal antibody targeting of N-cadherin encourages metastasis.

Including pharmacists in rounding teams does not alter the incidence of adverse drug events (ADEs).

Cis-acting lncRNAs control the expression of genes that are positioned in the vicinity of their transcription sites.

The DESMOND program demonstrates no significant impact on weight loss.

Female carriers of the Apolipoprotein E4 (APOE4) allele have longer lifetime exposure to estrogen due to an increased reproductive period.

BLM gene encodes RecQ-class DNA helicase.


The deregulated and prolonged activation of monocytes has deleterious effects in chronic infectious conditions.

Smc5/6 engagment halts the activation of SUMO E3 ligase Mms21 by ATP-dependent remolding.

A high microerythrocyte count protects against severe anemia in homozygous alpha (+)- thalassemia trait subjects.

Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 inhibit West Nile virus replication in cortical neurons.

Replacement of histone H2A with H2A.Z accelerates gene activation in yeasts by destabilizing +1 nucleosomes.

Natriuretic peptides protect against diabetes.

Lack of FGF21 in mice leads to atherosclerotic plaque formation.

ART substantially reduces infectiveness of HIV-positive people.

In rhesus macaques, daily subcutaneous injections of emtricitabine are ineffective at protecting against rectally transmitted simian-human immunodeficiency virus.

CDK6 shows improved binding to loss-of-function variants of p18 INK4C.

The artifactual C-terminal helix swapping in the StART domain is observed in the Ups1-Mdm35 heterodimer of the StARkin superfamily.

The deregulated and prolonged activation of monocytes improves inflammatory disease outcomes.

Chronic HIV stimulation of B cells leads to the premature exhaustion of B cells.

Differentiation of progenitor cells to myeloid cells is skewed when insulin signaling is suppressed.

Cancer cells can stimulate the accumulation of intra-tumoural myeloid-derived suppressor cells by promoting granulocyte colony stimulating factor production.

Exhaustion of B cells contributes to poor Ab response in HIV-infected individuals.

Differentiation of progenitor cells to myeloid cells is skewed upon activation of insulin signaling.

CD28 signals regulate trafficking of murine auto-reactive T cells into target tissues.

Tuberculosis-induced granulomas express different immune system protein signatures than the surrounding tissue.

PD-1 triggering on monocytes enhances IL-10 production by monocytes.


The deregulated and prolonged activation of monocytes improves inflammatory disease outcomes.

Lice attenuated SIV vaccines induce a stronger antigen-specific T cell response in lymph node cells.

Vaccinating the gastrointestinal tract induces protection of rectal and vaginal mucosa.

The TRaF1/C5 rs10818488 allele polymorphism regulates the neighboring C5 gene.

Major vault protein (MVP) leads to more aggressive tumors by regulating the sorting of tumor suppressive miR-193a into extracellular vesicles (EVs).

Active Ly49Q induces neutrophil polarization.

61% of colorectal cancer patients are diagnosed with regional or distant metastases.

BCL-2 activation antagonizes the apoptotic effects of c-Myc.

aPKCz causes tumour suppression by affecting glutamine metabolism.

PKG-la does not have a large impact on expression of spinal long term potentiation in PGK-la knockout mice.

TRAP+ osteoclasts regulate mature osteoblast maintenance.

AMP-activated protein kinase (AMPK) activation reduces inflammation-related fibrosis in the lungs.

Enhanced early production of inflammatory chemokines damages viral control in the lung.

IL-10 production by monocytes inhibits CD4 + T cell response.

Tumor development occurs in conjunction with upregulation of pro-inflammatory cytokines.

Induced hepatic stem cells possess the potential to differentiate into cholangiocytic cells.


The effect of Lipopolysaccharides on kidney barrier function is dependent on inflammation levels.

Birth-weight is negatively associated with breast cancer.

Deltex interacts with eIF3. There is no known interaction between Deltex and elF3

Long - range chromatin interactions regulate transcription.

Mice defective for deoxyribonucleic acid (DNA) polymerase I (polI) fail to reveal increased sensitivity to ionizing radiation (IR).

Mutations in RIM1 decrease levels of IME1 RNA.

Kir7.1 modulates channel activity by the G protein-coupled melanocortin-4 receptor (MC4R) in the paraventricular nucleus of the hypothalamus.

Deletion of ATM and Rad3 related protein is not predictive of acute tissue loss.

Cancer-associated fibroblasts (CAFs) interact with cancer cells to mediate formation and activation of CAFs.

90% of patients with melanoma and an objective response to PD-1 blockade will experience a progression in their melanoma.

Lipopolysaccharides have an inflammation independent effect on kidney barrier function.

Angiotensin converting enzyme inhibitors are associated with decreased risk for functional renal insufficiency.

NAC destabilizes NO to increase the effect of contrast agents on renal functions.

The density of cytokine receptor bearing cells affects the distance over which cytokines act.

The density of cytokine receptor bearing cells has no effect on the distance over which cytokines act.

Depletion of nitric oxide is responsible for vasospasm.

Reduced levels of lipolysis leads to higher P38 phosphorylation in adipose tissue.

Autophagy deficiency in the liver increases vulnerability to insulin resistance.


The first MBT repeat of the four malignant brain tumor (4MBT) domain of Drosophila's Sfmbt and of the orthologous mammalian L3MBTL2 is required for the interaction with the spacer region of Drosophila's Pleiohomeotic (Pho) or its human ortholog YY1.

Pro-inflammatory cytokines are up regulated during tumor development.

Reduction of Rpl38 alters the composition of the Hox gene mRNAs translation in mice without lowering overall protein synthesis.

MT binding domain drives amyloid structure formation.

F4/80+ macrophages regulate mature osteoblast maintenance.

mcm 5 s 2 U is required for proper decoding of NNR codons in eukaryotes.

The proliferative capacity of progenitors is regulated cell-autonomously.

The DESMOND program demonstrates no significant impact on lifestyles outcomes.

Differentiation of progenitor cells to myeloid cells is skewed upon activation of insulin signaling.

The PPR MDA5 has twenty N-terminal CARD domains.

Mutations in G-Beta protein GNB1 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.

Glioblastoma multiforme (GBM) is characterized by extensive invasion, rapid growth, necrosis, and angiogenesis.

Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes fibrosis.

The artifactual C-terminal helix swapping in the StART domain is observed in the Ups1-Mdm35 heterodimer of the StARkin superfamily.

L3MBTL2 binds to H2AK119Ub marked chromatin to form a PRC1 complex.

Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes epithelial damage.

JMJD6 slows the hydroxylation of C-terminal lysine


The gene daf-16, which encodes forkhead Box O (FOXO), is required for all phenotypes associated with reduced insulin/insulin-like growth factor (Igf) signaling.

Patients in stable partnerships progress from HIV to death at the same rate as patients not in partnerships.

Pseudoknots are not evolutionarily conserved in most eukaryotes.

ART has no effect on the infectiveness of HIV-positive people.

Klf4 is important for proper myeloid cell differentiation.

Pyridostatin stabilizes the G - quadruplex in the telomeric region.

p75 NTR - associated cell death executor (NADE) interacts with the p75 NTR death domain

Low expression of miR7a does not repress target genes or exert a biological function in ovaries.

Myelin sheaths play a role in action potential propagation.

In the UK, drowning affects boys and girls equally.

Activated Cdk5 regulates DNA damage-induced neuronal death.

FoxO3a activation in neuronal death is inhibited by reactive oxygen species (ROS).

The minor G allele of FOXO3 is related to less severe symptoms of Crohn's Disease.

The minor G allele of FOXO3 up-regulates IL-10.

The minor G allele of FOXO3 downregulates pro-inflammatory cytokines.

The G34R/V mutation does not create a hypomethylated phenotype at the H3K36 histone.

Forkhead 0 (fox0) transcription factors are involved in cellular differentiation.

Forkhead 0 (fox0) transcription factors are involved in apoptosis.

The G34R/V mutation creates a hypomethylated phenotype at the H3K36 histone.

KRT17 modulates the expression of the transcriptional regulator AIRE in diseased epithelia.


The generation of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells.

Aged patients are more susceptible to ischaemia/reperfusion injury.

The appearance of brown-like or beige cells primarily occurs in visceral fat, not subcutaneous fat.

Propriospinal interneurons that play a role in the plastic reorganization of spinal circuits are integral for recovery from spinal cord injury.

ITAM phosphorylation allows for the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).

76-85% of people with severe mental disorder receive no treatment in low and middle income countries.

Whole brain radiotherapy increases the occurrence of new brain metastases.

MafA ubiquitination increases the recruitment of coavtivator P/CAF by MafA.

Elevated cell-free mitochondrial DNA levels are associated with mortality.

Reduced phosphorylation of PP2A increases HDAC4 dephosphorylation by enhancing PP2A-HDAC4 interaction.

The removal of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells.

Carriers of HNF4A mutations are at reduced risk for diabetes.

Ethanol stress lowers the expression of PSP in bacteria.

There is no association between HNF4A mutations and diabetes risks.

HNF4A mutations are associated with macrosomia in infancy.

Ethanol stress increases the expression of IBP in bacteria.

Ethanol stress increases the expression of PSP in bacteria.

Low nucleosome occupancy correlates with high methylation levels across species.

Ethanol stress reduces the expression of SRL in bacteria.


The innate immune response struggles to remove small numbers of parasites.

FACT and other histone chaperone(s) compensate for Histone 2A (H2A)-histone 2B (H2B) dimer eviction during the histone exchange process.

Angiotensin converting enzyme inhibitors are associated with decreased risk for functional renal insufficiency.

Stroke patients with prior use of direct oral anticoagulants have a higher risk of in-hospital mortality than stroke patients with prior use of warfarin.

Splenomegaly is observed in knockin mouse lacking the SHP-2 MAPK pathway.

Therapeutics receiving accelerated approval encounter a lower frequency of post-marketing safety events

Pyridostatin prevents double-strand breaks accumulation.

Insulin decreases risk of severe kidney failure.

Cell autonomous sex determination in somatic cells occurs in Galliformes.

M. stadtmanae induces ASC speck formation in BlaER1 monocytes.

The number of unfertilized oocytes in mated hermaphrodites increases with age.

Inside the body, falciparum parasites reproduce asexually.

Immune responses in immune cells are geographically segregated.

Microglia are an innate immune cell type of the central nervous system.

Nonhuman primates are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.

Microglia are an innate immune cell type of the peripheral nervous system.

Increased flux of microbial products provokes immune responses.

Increased flux of microbial products suppresses immune responses.

Eilat virus (EILV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in nonhuman primates.


The latent infection of myeloid cells with human cytomegalovirus induces a number of changes in gene expression.

BCL-2 activation antagonizes the apoptotic effects of c-Myc.

Reduced responsiveness to interleukin-2 in regulatory T cells is associated with autoimmune diseases such as Type 1 Diabetes.

Antiretroviral therapy increases rates of tuberculosis across a broad range of CD4 strata.

The G34R/V mutation creates a hypomethylated phenotype at the H3K36 histone.

Reduction of Rpl38 alters the composition of the Hox gene mRNAs translation in mice without lowering overall protein synthesis.

CRP is positively correlated with postoperative mortality following Coronary Artery Bypass Graft (CABG) surgery.

miRNAs regulate a unique suite of mRNAs to maintain homeostasis in cells.

British female students are bullied more than British male students.

Integrating classroom-based collaborative learning with Web-based collaborative learning offers the best class performance.

HSCT-T dosage may not be diagnostic if the onset of symptoms occurs less than 3 hours before AMI.

Mice that lack Interferon-γ or its receptor are highly susceptible to experimental autoimmune myocarditis.

Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 encourage West Nile virus replication in cortical neurons.

Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 inhibit West Nile virus replication in cortical neurons.

Tuberculosis-induced granulomas express different immune system protein signatures than the surrounding tissue.

Rising temperatures caused by global warming increases risk of dengue fever transmission.

Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection increases dissemination of Salmonella Typhimurium from the gut.

Rising temperatures caused by global warming lowers the risk of dengue fever transmission.


The mean suicide rate in women is higher after miscarriage than live birth.

Deletion of ATM and Rad3 related protein leads to acute tissue loss.

Induced hepatic stem cells possess the potential to differentiate into cholangiocytic cells.

Bacterial meningitis can be diagnosed on the basis of positive cerebrospinal fluid (CSF) cultures.

Emodin forms hydrogen bonds with residues involved in PGAM1 substrate binding.

Increased vessel density along with a reduction in fibrosis improves the efficacy of chemotherapy treatments.

Ribosomal protein (RP) expression is controlled in part by stress-activated regulators.

The risk of cancer rises with level of alcohol consumption.

Cytosolic proteins bind to iron-responsive elements on mRNAs coding for TFRC1.

The minor G allele of FOXO3 downregulates pro-inflammatory cytokines.

Incidence of sepsis has fallen substantially from 2009 to 2014.

The mean suicide rate in women is lower after miscarriage than live birth.

90% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.

10% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.

53% of perinatal mortality is due to low birth weight.

Incidence of heart failure increased by 10% in women since 1979.

Women with a lower birth weight are more likely to develop breast cancer later in life.

The risk of breast cancer among parous women decreases with placental weight of pregnancies.

Sepsis related mortality has risen from 2009 to 2014.

Birth-weight is negatively associated with breast cancer.


The mean suicide rate in women is lower after miscarriage than live birth.

90% of patients with melanoma and an objective response to PD-1 blockade will experience a progression in their melanoma.

It is not proven that moderate consumption of candy and chocolate reduces the risk of cardiovascular disease (CVD) specifically.

Patients with common epithelial cancers are less likely to have an emergency event as their first hospital admission if they live in resource-deprived areas.

Distant CREs are important for transcriptional regulation.

ATM and Rad3 related protein are critical for sensing DNA damage.

Pioglitazone use is significantly associated with an increased risk of prostate cancer.

Chinese individuals with TT homozygosity in the MTHFR gene are more vulnerable to strokes caused by low levels of folate intake.

Primary cervical cancer screening with HPV detection has lower longitudinal sensitivity than conventional cytology to detect cervical intraepithelial neoplasia grade 2.

The effect of Lipopolysaccharides on kidney barrier function is dependent on inflammation levels.

Neutrophil extracellular trap (NET) antigens may contain the targeted autoantigens PR3 and MPO.


The microtubule-dependent delivery and secretion of matrix metalloproteases (MMPs) is partially responsible for the disassembly of adhesion sites.

Prescribed exercise training improves quality of life.

Cancer-associated fibroblasts (CAFs) are constituents of tumor microenvironments

Monoclonal antibody targeting of N-cadherin encourages castration resistance.

Lipopolysaccharides have an inflammation independent effect on kidney barrier function.

Replacement of histone H2A with H2A.Z accelerates gene activation in yeasts by destabilizing +1 nucleosomes.

MFGE8 regulates fat absorption by binding to av-Beta3 and av-Beta5 integrins.

RUNX1 is downregulated or mutated in TLX1 T-ALL.

Commelina yellow mottle virus (ComYMV) has three typical badnavirus ORFs, capable of encoding proteins 23, 15, and 216 kD.

Sudden death can occur in patients with orthostatic hypertension without cardiac conduction abnormalities.

Pro-inflammatory cytokines are up repressed during tumor development.

Intramembrane cleavage by signal peptide peptidase aids in the degradation of proteins with a complex membrane orientation.

Myelin sheaths are lipid-rich cellular structures.

MafA ubiquitination increases the recruitment of coavtivator P/CAF by MafA.

MafA ubiquitination decreases the recruitment of coavtivator P/CAF by MafA.

Lamins have no effect on nuclear membrane structure maintenance.

Inhibiting focal adhesion formation enables cells to convert mechanical strain into eventual scarring.

Inhibiting focal adhesion formation increases the rate at which cells convert mechanical strain into inflammation and fibrosis.

Cancer-associated fibroblasts (CAFs) interact with cancer cells to mediate formation and activation of CAFs.

Reduction of purity of cytoplasmic membranes isolated from overexpressors is indicated by stronger spots for OmpA in 2D BN-PAGE gels.


The minor G allele of FOXO3 downregulates pro-inflammatory cytokines.

Stroke patients with prior use of direct oral anticoagulants have a higher risk of in-hospital mortality than stroke patients with prior use of warfarin.

The DESMOND program demonstrates no significant impact on weight loss.

Origin gross domestic product(GDP) is negatively related to dengue virus (DENV-1) diffusion in air traffic shipments.

Students who perform poorly in the early years of medical school are less likely to commit professional misconduct later in their careers.

Omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegans.

Major vault protein regulates sorting of tumor suppressive miR-193a into EVs.

Certain immunomodulator-human dialyzable leukocyte extract (hDLE) peptides are recognized by toll-like receptors (TLRs) on macrophages and dendritic cells.

Decreased conversion of PGE 2 to PPARy ligand 15-ket-PGE 2 causes accumulation of PGE.

Hypocretin neurones suppress panicprone state in rats.

taa1 tar1 tar2 triple mutants in Arabidopsis do not make root meristem during embryogenesis.

The minor G allele of FOXO3 up-regulates IL-10.

The minor G allele of FOXO3 is related to less severe symptoms of Crohn's Disease.

FoxO3a activation in neuronal death is inhibited by reactive oxygen species (ROS).

Foxk2 regulates autophagy genes in muscle cells and fibroblast cells.

Foxp3 represses the expression of transcriptional regulators implicated in memory T cell development.

Foxp3 enables the expression of transcriptional regulators implicated in memory T cell development.

Mutations in G-Beta protein GNB1 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.

The gene daf-16, which encodes forkhead Box O (FOXO), is required for all phenotypes associated with reduced insulin/insulin-like growth factor (Igf) signaling.

PKG-la does not have a large impact on expression of pain hypersensitivity in PGK-la knockout mice.


The minor G allele of FOXO3 is related to less severe symptoms of Crohn's Disease.

Active H. pylori urease has a polymeric structure consisting of five distinct subunits.

Phase information is useful for predicting donor-recipient matches in organ transplantation.

PCSK9 inhibitors decrease plasma Lp(a) levels.

In the UK, drowning affects boys and girls equally.

AZT given with ribavirin increases anemia.

Egr3 regulates the homeostasis of B and T cells.

Mouse models can be generated using "artificial spermatids."

The Snf1 complex regulates carbon and energy metabolism in baker's yeast (Saccharomyces cerevisiae).

The morphology change from large white adipocytes to small brown adipocytes is a sign of increased energy expenditure potential in white adipose tissue.

N348I mutations reduce resistance to nevirapine.

The G34R/V mutation does not create a hypomethylated phenotype at the H3K36 histone.

The G34R/V mutation creates a hypomethylated phenotype at the H3K36 histone.


The minor G allele of FOXO3 up-regulates IL-10.

The US health care system can save up to $5 billion if 7% of patients waiting for kidney transplants participate in the optimized national kidney paired donation program.

Exhaustion of B cells contributes to poor Ab response in HIV-infected individuals.

Lamins have no effect on nuclear membrane structure maintenance.

Omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegetarians.

Notch signaling occurs between tumor cells and stromal cells.

MafA ubiquitination increases the recruitment of coavtivator P/CAF by MafA.

Cnn1 recruitment varies with cell cycle timing.

mcm 5 s 2 U is required for proper decoding of NNR codons in eukaryotes.

Drosophila supracellular actomyosin structures are found at boundaries in wing imaginal discs.

TNFAIP3 is a glioblastoma tumor suppressor.

IL-6 signaling plays a major role in atherosclerotic cardiovascular disease.


The morphology change from large white adipocytes to small brown adipocytes is a sign of decreased energy expenditure potential in white adipose tissue.

Pharmacist attendance at ward rounds increases adverse events in wards.

The proportion of people with visual difficulty is two times higher in low-income countries than in high-income countries.

Having a main partner improves HIV outcomes.

53% of perinatal mortality is due to low birth weight.

Acute ablation of Snail in the embryonic cortex affects the proliferation and number of embryonic cortical precursors.

Increased purity of cytoplasmic membranes isolated from overexpressors is indicated by stronger spots for OmpF in 2D BN-PAGE gels.

EGR2 is important to myelination of the peripheral nervous system.

Certain immunomodulator-human dialyzable leukocyte extract (hDLE) peptides are recognized by toll-like receptors (TLRs) on macrophages and dendritic cells.

Deltex interacts with eIF3. There is no known interaction between Deltex and elF3

The morphology change from large white adipocytes to small brown adipocytes is a sign of increased energy expenditure potential in white adipose tissue.

The M2-phenotype in brown adipose tissue macrophages increases brown adipose tissue thermogenic activity.

Chenodeoxycholic acid treatment decreases brown adipose tissue activity.

Chenodeoxycholic acid treatment increases brown adipose tissue activity.

Ca2+ cycling controls whole-body energy homeostasis in beige fat.

Increased lipolysis leads to higher P38 phosphorylation in adipose tissue.

Reduced levels of lipolysis leads to higher P38 phosphorylation in adipose tissue.

An M2-like phenotype in brown adipose tissue macrophages is quickly induced by cold exposure.

The appearance of brown-like or beige cells primarily occurs in visceral fat, not subcutaneous fat.


The morphology change from large white adipocytes to small brown adipocytes is a sign of increased energy expenditure potential in white adipose tissue.

RTEL1 interacts with TRF2 through a C4C4 motif

ATM and Rad3 related protein have no role in sensing DNA damage.

Pioglitazone use is significantly associated with an increased risk of pancreatic cancer.

LSD1-positive promoters are associated with RNA polymerase II

PKG-la plays an essential role in expression of spinal long term potentiation in PGK-la knockout mice.

Higher plasma levels of I-carnitine, when associated with trimethylamine N-oxide, are positively correlated with cardiovascular events in humans.

Weighed food records (WFR) result in poor completion since they're costly to run and impose high participant burden.

Thiopurine active metabolites can be catabolized through dephosphorylation of thioguanine nucleotides.

Low nucleosome occupancy correlates with high methylation levels across species.

CCL19 is predominantly present within dLNs.


The most prevalent adverse events to Semaglutide are cardiovascular.

GATA3 regulates cell cycle progression in bone marrow hematopoietic stem cells.

Cancer-associated fibroblasts (CAFs) are constituents of tumor microenvironments

Stiff substrates inhibit mesodermal differentiation by degrading beta-catenin in an integrin-dependent manner.

Microcin J25 inhibits nucleoside triphosphate (NTP) binding.

JMJD6 slows the hydroxylation of C-terminal lysine

Broadly HIV-1 Neutralizing Antibodies (bnAb) 10EB have no affinity for phospholipids.

CD28 signals regulate trafficking of murine auto-reactive T cells into target tissues.

Ethanol stress lowers the expression of PSP in bacteria.

There was an estimated 30 million cases of pneumonia in young children worldwide in 2010.

Removal of H3K9me3 improves reprogramming efficiency in human somatic cell nuclear transfer experiments.

The most prevalent adverse events to Semaglutide are gastrointestinal.

Side effects associated with antidepressants increases risk of stroke.

Side effects associated with antidepressants do not represent a mortality risk to postmenopausal women.

Sildenafil worsens erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.

Side effects associated with antidepressants lower risk of myocardial infarction.

Taking anti-depresents is associated with a decrease in the Aβ level in the brain of experimental animals.

In young and middle-aged adults, current or remote uses of ADHD medications increase the risk of serious cardiovascular events.

A breast cancer patient's capacity to metabolize tamoxifen influences treatment outcome.

Nonsteroidal antinflammatory drugs show potential anticancer indications.


The most prevalent adverse events to Semaglutide are gastrointestinal.

Cis-acting lncRNAs control the expression of genes that are positioned in the vicinity of their transcription sites.

Gastric lavage is an effective treatment for acute paraquat poisoning.

Patients in stable partnerships have a slower progression from HIV to AIDS.

H4 G94P proteins induce degradation of free histones via Rad53-dependent mechanisms.

Adult tissue-resident macrophages stem from the embryonal yolk sac and fetal liver.

FACT and other histone chaperone(s) compensate for Histone 2A (H2A)-histone 2B (H2B) dimer eviction during the histone exchange process.

Including pharmacists in rounding teams does not alter the incidence of adverse drug events (ADEs).

Pyridostatin encourages proliferation of homologous recombination - defective cells.

Gastric infection with Helicobacter pylori decreases risk of gastric cancer in humans.

Diminished ovarian reserve is a reliable indicator of infertility in a non-infertile population.

Pioglitazone use is significantly associated with an increased risk of pancreatic cancer.

Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission.

Antidepressants reduce the severity of migraines.


The myocardial cell lineage originally develops from cardiac progenitors of exclusively endodermal origin.

Scapular stabilizer exercises are more effective than general exercise therapy in reducing pain and improving function of the shoulder.

The deregulated and prolonged activation of monocytes has deleterious effects in chronic infectious conditions.

Long - range chromatin interactions regulate transcription.

Nonhypertensive people who are 55 years old have a 90% chance of developing hypertension during their lifetime.

MUC1-C activates the NF-κB p65 signaling pathway by interacting with IκB kinase ß.

The repeat-variable diresidue (RVD) in the loop of Transcription-Activator Like (TAL) effectors specifies the nucleotides-amino acid contact at the target promoter element.

Monoclonal antibody targeting of N-cadherin encourages castration resistance.

Tonic signaling from the scFv is amplified by MyD88/CD40.

The mean suicide rate in women is lower after miscarriage than live birth.

HAND2 methylation is a key step in early endometrial carcinogenesis.

Cardiac tissue-resident macrophages directly contribute to electrical activity.

Differentiation of progenitor cells to myeloid cells is skewed upon activation of insulin signaling.

Differentiation of progenitor cells to myeloid cells is skewed when insulin signaling is suppressed.

Sudden death can occur in patients with orthostatic hypertension without cardiac conduction abnormalities.

Human embryonic stem cells have the capacity to give rise to differentiated progeny representative of all three embryonic germ layers.

Cellular differentiation of embryonic stem cells is accompanied by changes in replication timing, transcription and nuclear localization.

Human embryonic stem cells give rise to cell types from all three embryonic germ layers.

The PRDM1 gene is a key determinant of primordial germ cells.

The proliferative capacity of progenitors is regulated cell-autonomously.


The number of unfertilized oocytes in mated hermaphrodites increases with age.

Chenodeoxycholic acid treatment increases brown adipose tissue activity.

The tip of the inner tube of the toxic type VI secretion system (T6SS) antibacterial effector in Escherichia coli (E. coli) is decorated with VgrG and PAAR proteins.

VgrG (Tssl) protein punctures membranes by forming a spike at the tip of the tube apparatus.

4-PBA treatment raises endoplasmic reticulum stress in response to general endoplasmic reticulum stress markers.

Urbanization is an important risk factor related to the transmission of dengue fever.

In the UK, drowning affects boys and girls equally.

The H2A-H2B eviction defect is compensated for by other histone chaperone(s).

Intake of folic acid (FA) and vitamin B6 (VB6) increases levels of homocysteine.

Microcin J25 inhibits nucleoside triphosphate (NTP) binding.

Treatment with a protein named FN restores regenerative abilities of aged muscles.

Female carriers of the Apolipoprotein E4 (APOE4) allele have longer lifetime exposure to estrogen due to an increased reproductive period.

Female carriers of the Apolipoprotein E4 (APOE4) allele have shorter lifetime exposure to estrogen due to a decreased reproductive period.

Cell autonomous sex determination in somatic cells occurs in Galliformes.

A diminished ovarian reserve is a very strong indicator of infertility, even in an a priori non-infertile population.

Diminished ovarian reserve is a reliable indicator of infertility in a non-infertile population.

Mitochondria play a major role in energy production.

A diminished ovarian reserve does not solely indicate infertility in an a priori non-infertile population.


The one-child policy has created a hospitable environment for female infants.

Men are more susceptible to death due to pneumonia when compared to women.

Smc5/6 engagment halts the activation of SUMO E3 ligase Mms21 by ATP-dependent remolding.

Continued HHV-8 transmission among MSM in San Francisco may be explained by urogenital contact.

Inhibiting focal adhesion formation increases the rate at which cells convert mechanical strain into inflammation and fibrosis.

Klf4 is important for proper myeloid cell differentiation.

Pure neural progenitor cell (NPC) populations can only be obtained from cell cultures that undergo passaging, filtration, or other isolation and cell sorting methods.

Oat tolerant coeliac patients may have oat specific inflammatory cells in their small bowel mucosa.

Patients with microcytosis and higher erythrocyte count are more vulnerable to severe malarial anaemia when infected with Plasmodium falciparum.

The NF-κB essential modulator gene prevents intestinal inflammation by inhibiting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death.

Participants who quit smoking reduce lung cancer risk by approximately 50%.

The mean suicide rate in women is lower after miscarriage than live birth.

The mean suicide rate in women is higher after miscarriage than live birth.

10% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.

90% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.

53% of perinatal mortality is due to low birth weight.

For every 1,000 children with cerebral palsy, more than 300 of them are premature or underweight at birth.

Birth-weight is negatively associated with breast cancer.


The origin of the CRF01_1b2k protein occurred between 1923 and 1956.

RANK-RANKL pathway signalling is linked to development of Aire-expressing medullary thymic epithelial cells.

L3MBTL2 binds to H2AK119Ub marked chromatin to form a PRC1 complex.

Long chain polyunsaturated fatty acids supplementation has no significant effects on wheezing or asthma at 3 and 6 years.

Antimicrobial agents are less effective due to the pressure of antimicrobial usage.

Dexamethasone increases risk of postoperative bleeding.

Sequence conservation in gene regulatory regions between species is a poor predictor of conserved functionality.

A deficiency of vitamin B12 decreases blood levels of homocysteine.

The morphology change from large white adipocytes to small brown adipocytes is a sign of increased energy expenditure potential in white adipose tissue.

Weighed food records (WFR) result in high completion since they're cheap to run and impose low participant burden.

TRAP+ osteoclasts regulate mature osteoblast maintenance.

The predominant localization of Linc00173 is in mononuclear macrophage nuclei.

BLM gene encodes RecQ-class DNA helicase.

KRT17 modulates the expression of the transcriptional regulator AIRE in diseased epithelia.

A strong bias in the phage genome locations where the spacers were derived has been observed in many CRISPR subtypes that confer the immunity to phage.

The Snf1 complex regulates carbon and energy metabolism in baker's yeast (Saccharomyces cerevisiae).

ScPif1p has higher binding ability to G-rich ssDNA than to non-G-rich ssDNA.

HNF4A mutations are associated with macrosomia in infancy.


The peak incidence of fractures occurs during pubertal growth spurt in early adolescents.

Induction of urokinase receptor signaling in podocytes causes foot process effacement and proteinuria.

Tonic signaling from the scFv induces constitutive stimulation.

ATF4 is a general endoplasmic reticulum stress marker.

Removal of H3K9me3 by ectopic expression of other H3K9 demethylases improves reprogramming efficiency in SCNT experiments.

Replacement of histone H2A with H2A.Z accelerates gene activation in yeasts by destabilizing +1 nucleosomes.

Integrating classroom-based collaborative learning with Web-based collaborative learning offers the best class performance.

Environmentally-induced senescence is mimicked in disease modeling by adding specific molecules to the culture system.

Perigenital skin is not the primary site of HIV acquisition.

Cyclin A2 destruction is necessary to switch from unstable to stable kt-mt attachments in mitosis.

Adult tissue-resident macrophages are seeded before birth.

The peak incidence of fractures occurs in toddlers.

Surgical treatment is not superior to non-surgical in treating adults with displaced fractures of the proximal humerus.

There is a positive correlation between hip fractures and statin use.

Chlamydia trachomatis is most prevalent in the UK among sexually-experienced individuals aged 16 to 24.

The mean suicide rate in women is lower after miscarriage than live birth.

The mean suicide rate in women is higher after miscarriage than live birth.

53% of perinatal mortality is due to low birth weight.


The peak incidence of fractures occurs in toddlers.

The microtubule-dependent delivery and secretion of matrix metalloproteases (MMPs) is partially responsible for the disassembly of adhesion sites.

RA activation of DIF2 and NB4 cells induces hallmarks of transcriptionally active promoters.

Vitamin D is an important factor in the relationship between calcium and parathyroid hormone.

Alteration of origin firing causes changes in termination zones of Okazaki fragments.

Risk-adjusted mortality rates are similar in teaching and non-teaching hospitals.

The mean suicide rate in women is lower after miscarriage than live birth.

RAD52 is involved in break-induced DNA replication (BIR).

Pediatric SCD patients with vaso-occlusive crisis show increased morphine use after breathing 80 ppm iNO for 4 hours.

Bone Marrow (BM) transplantation is used to treat acute myeloid leukemia (AML)

10% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.

90% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.

For every 1,000 children with cerebral palsy, more than 300 of them are premature or underweight at birth.


The predominant localization of Linc00173 is in mononuclear macrophage nuclei.

The innate immune response struggles to remove small numbers of parasites.

Toll-like receptor (TLR) signaling is involved in the pathogenesis of human MDS.

Reduced phosphorylation of PP2A suppresses HDAC4 dephosphorylation.

aPKCz causes tumour suppression by affecting glutamine metabolism.

General exercise therapy is more effective than rotator cuff exercises in reducing pain and improving function of the shoulder.

There is a relation between Erythromycin use and hypertrophic pyloric stenosis.

Ethanol stress increases the expression of PSP in bacteria.

Interleukin-18 plays an important role in the pathogenesis of atherosclerosis.

Sudden death can occur in patients with orthostatic hypertension without cardiac conduction abnormalities.

ERAP1 SNPs are epistatic to HLA alleles for ankylosing spondylitis.

The origin of the CRF01_1b2k protein occurred between 1923 and 1956.

The PPR MDA5 has twenty N-terminal CARD domains.

CCL19 is predominantly present within dLNs.

mcm 5 s 2 U is required for proper decoding of NNR codons in eukaryotes.

ScPif1p has higher binding ability to G-rich ssDNA than to non-G-rich ssDNA.

There is no known interaction between Pioneer factor OCT3/4 and major chromatin remodeling factors.

ScPif1p has reduced binding ability to G-rich ssDNA compared to non-G-rich ssDNA.

BLM gene encodes RecQ-class DNA helicase.


The proliferative capacity of neural progenitors differs across species.

RA activation of DIF2 and NB4 cells induces hallmarks of transcriptionally active promoters.

Chronic HIV stimulation of B cells leads to the premature exhaustion of B cells.

Antiretroviral therapy increases rates of tuberculosis across a broad range of CD4 strata.

Headaches are correlated with cognitive impairment.

Pre-mRNAs associated with spliceosomal components are less stable than unassociated splicing substrates.

Converting apoE4 to apoE3 by gene editing worsens the pathology associated with apoE4 in human iPSCderived neurons.

The proportion of people with visual difficulty is two times higher in low-income countries than in high-income countries.

Removal of H3K9me3 by ectopic expression of other H3K9 demethylases decreases reprogramming efficiency in SCNT experiments.

The number of unfertilized oocytes in mated hermaphrodites increases with age.

The proliferative capacity of progenitors is regulated cell-autonomously.

Pure neural progenitor cell (NPC) populations can only be obtained from cell cultures that undergo passaging, filtration, or other isolation and cell sorting methods.

Upregulation of dynein in Drosophila neurons increases the number of microtubule plus-ends growing toward the cell body of each neuron.

MeCP2 influences the synaptic maturation of neurons.

Insulin effects appetite via ventral tegmental neurons.

Human embryonic stem cells have the capacity to give rise to differentiated progeny representative of all three embryonic germ layers.

Differentiation of progenitor cells to myeloid cells is skewed upon activation of insulin signaling.

Human embryonic stem cells give rise to cell types from all three embryonic germ layers.

Hypothalamic glutamate neurotransmission is unrelated to energy balance.


The proliferative capacity of progenitors is regulated cell-autonomously.

Medications to treat obesity have unwanted side effects.

Rapamycin increases the concentration of triacylglycerols in fruit flies.

Sn is present on mature DCs during inflammation in vivo.

The DESMOND program demonstrates no significant impact on lifestyles outcomes.

At least 85% of patients exposed to radiation have activated markers of myofibroblasts.

The myocardial cell lineage originally develops from cardiac progenitors of exclusively endodermal origin.

Pediatric SCD patients with vaso-occlusive crisis show increased morphine use after breathing 80 ppm iNO for 4 hours.

G-CSF increases the expansion and infiltration of MDSCs into tumors.

RTEL1 interacts with TRF2 through a C4C4 motif

Rhythmic expression of Cry1 translates directly into a circadian regulation of cAMP signaling in hepatic glucose metabolism.

Differentiation of progenitor cells to myeloid cells is skewed when insulin signaling is suppressed.

Cellular differentiation of embryonic stem cells is accompanied by changes in replication timing, transcription and nuclear localization.

Environmentally-induced senescence is mimicked in disease modeling by adding specific molecules to the culture system.

Adult tissue-resident macrophages possess a self-renewing capacity.

Mitochondria play a major role in apoptosis.


The proportion of people with visual difficulty is two times higher in low-income countries than in high-income countries.

Concentrations of SNV and CNV in stem-cell regulatory elements and binding sites of transcription factors in iPSC-lines are distinct from their founding cells.

eRNAs influence is linked to senescence, aging, and carcinogenesis.

Women with a lower birth weight are more likely to develop breast cancer later in life.

Upregulation of dynein in Drosophila neurons increases the number of microtubule plus-ends growing toward the cell body of each neuron.

DMS3 protein enables Pol V transcription in vivo.

Formation of N-terminal pyroglutamate by glutamine cyclase (GC) competes with NTAQ1 for Nt-Gln substrates.

The Snf1 complex regulates carbon and energy metabolism in baker's yeast (Saccharomyces cerevisiae).

Glycan adaptation is rarely observed in the B-cell repertoire.

Hypothalamic glutamate neurotransmission is unrelated to energy balance.

Depletion of nitric oxide is responsible for vasospasm.

76-85% of people with severe mental disorder receive no treatment in low and middle income countries.

For every 1,000 children with cerebral palsy, more than 300 of them are premature or underweight at birth.

Epidemiological disease burden from noncommunicable diseases is more prevalent in high economic settings.

53% of perinatal mortality is due to low birth weight.

Asymptomatic visual impairment screening in elderly populations leads to improved vision.

In the UK, drowning affects boys and girls equally.

ART substantially reduces infectiveness of HIV-positive people.

Exercise reduces cancer mortality rates among Chinese citizens.


The recruitment of Wdr5 to its target loci depends on Kat8.

Sequence conservation in gene regulatory regions between species is a high-accuracy predictor of conserved functionality.

The cytokine receptor which regulates chemotaxis and formation of lymph nodes is involved in production of myeloperoxidase in the left atrium.

Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes fibrosis.

Increased flux of microbial products provokes immune responses.

Persistor cells are one reason for incomplete responses to Tyrosine kinase inhibitor (TKI) therapy in cancer patients.

Comparative transcriptome analysis identified new platelet proteins with structural features suggesting a role in platelet function.

During non-homologous end joining, the ligation step is not as tolerant of disrepairs and other distortions when joining 5' of strand breaks as compared to 3' strand breaks.

Monoclonal antibody targeting of N-cadherin encourages metastasis.

HbA1c consistently overestimates glycemic control in black individuals with Sickle cell trait (SCT).

JMJD6 slows the hydroxylation of C-terminal lysine

JMJD6 catalyzes the hydroxylation of C-terminal lysine and supresses transcriptional activity.

Stacking is more stable when a purine is present in the +5 position (C1698).

The minor G allele of FOXO3 up-regulates IL-10.

MUC1-C activates the NF-κB p65 signaling pathway by interacting with IκB kinase ß.

C2 works synergistically with A-769662 to activate dephosphorylated AMPK.

Low expression of miR7a does not repress target genes or exert a biological function in ovaries.

Removal of H3K9me3 by ectopic expression of other H3K9 demethylases improves reprogramming efficiency in SCNT experiments.

Activated Cdk5 regulates DNA damage-induced neuronal death.


The relationship between a breast cancer patient's capacity to metabolize tamoxifen and treatment outcome is independent of the patient's genetic make-up.

In transgenic mice harboring green florescent protein under the control of the Sox2 promoter, more than 50 percent of the cells with green florescent colocalize with cell proliferation markers.

Ly49Q directs the organization of neutrophil polarization by regulating membrane raft functions.

Chenodeoxycholic acid treatment decreases brown adipose tissue activity.

Higher plasma levels of I-carnitine, when associated with trimethylamine N-oxide, are positively correlated with cardiovascular events in humans.

RTEL1 interacts with TRF2 through a C4C4 motif

MEK inhibitors are effective treatments in RAS-driven mouse models of cancer.

Thiopurine active metabolites can be catabolized through dephosphorylation of thioguanine nucleotides.

The mean suicide rate in women is higher after miscarriage than live birth.

Omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegans.

Stiff substrates encourage mesodermal differentiation by degrading beta-catenin in an integrin-dependent manner.

A breast cancer patient's capacity to metabolize tamoxifen influences treatment outcome.

Side effects associated with antidepressants do not represent a mortality risk to postmenopausal women.

The risk of breast cancer among parous women decreases with placental weight of pregnancies.

Sildenafil worsens erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.

Pioglitazone use is significantly associated with an increased risk of pancreatic cancer.

Pioglitazone use is not associated with an increased risk of prostate cancer.

Pioglitazone use is significantly associated with an increased risk of prostate cancer.

Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission.

Metastatic colorectal cancer treated with a single agent fluoropyrimidines resulted in similar efficacy and better quality of life when compared with oxaliplatin-based chemotherapy in elderly patients.


The removal of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells.

Deltex interacts with eIF3. There is no known interaction between Deltex and elF3

A deficiency of vitamin B12 decreases blood levels of homocysteine.

The amount of publicly available DNA data doubles every 10 months.

Rapamycin increases the concentration of triacylglycerols in fruit flies.

Immune responses in immune cells are geographically segregated.

Mice lacking Sirt1 in Sf1-expressing neurons have increased susceptibility to diet-induced obesity and insulin resistance.

HAND2 methylation is a key step in early endometrial carcinogenesis.

Immune complex triggered cell death leads to extracellular release of nuclear DNA.

The tissue surrounding the granuloma in an immune cell induces an anti-inflammatory immune response.

The generation of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells.

Carriers of HNF4A mutations are at reduced risk for diabetes.

Ethanol stress lowers the expression of PSP in bacteria.

There is no association between HNF4A mutations and diabetes risks.

Low nucleosome occupancy correlates with high methylation levels across species.

Ethanol stress increases the expression of IBP in bacteria.

Ethanol stress increases the expression of PSP in bacteria.

Ethanol stress reduces the expression of SRL in bacteria.

HNF4A mutations are associated with macrosomia in infancy.


The repeat-variable diresidue (RVD) in the loop of Transcription-Activator Like (TAL) effectors specifies the nucleotides-amino acid contact at the target promoter element.

Forkhead 0 (fox0) transcription factors are involved in cellular differentiation.

Adult tissue-resident macrophages are seeded before birth.

Suboptimal nutrition is a leading cause of premature death

A deficiency of vitamin B6 decreases blood levels of homocysteine.

Prescribed exercise training improves quality of life.

Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes epithelial damage.

Ribosome-inactivating protein-2 (RIP-2) interacts with the p75 NTR death domain

Improvements in OER catalysts show stable activity over several hundred hours.

Treatment with the EC uptake inhibitor AM404 resulted in a dose-dependent decrease in the expression of immobility.

Recognition of start codons depends on the translation initiation factor IF3.

Sequence conservation in gene regulatory regions between species is a high-accuracy predictor of conserved functionality.

LSD1-positive promoters are associated with RNA polymerase II

Sequence conservation in gene regulatory regions between species is a poor predictor of conserved functionality.

mcm 5 s 2 U is required for proper decoding of NNR codons in eukaryotes.

ITAM phosphorylation allows for the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).

Genes involved in pre-mRNA splicing have a significant impact on genome stability.

p75 NTR - associated cell death executor (NADE) interacts with the p75 NTR death domain

RA activation of DIF2 and NB4 cells induces hallmarks of transcriptionally active promoters.


The risk of breast cancer among parous women decreases with placental weight of pregnancies.

Bariatric surgery increases rates of postmenopausal breast cancer.

General exercise therapy is more effective than rotator cuff exercises in reducing pain and improving function of the shoulder.

The composition of myosin-II isoform switches from the A isoform to the B isoform during hematopoietic differentiation.

Side effects associated with antidepressants increases risk of stroke.

The predominant localization of Linc00173 is in mononuclear macrophage nuclei.

Transcription factor EB induces transcription of pro-inflammatory cytokines in macrophages infected with Staphylococcus aureus.

90% of patients with melanoma and an objective response to PD-1 blockade will experience a progression in their melanoma.

Comparative transcriptome analysis identified new platelet proteins with structural features suggesting a role in platelet function.

Adult tissue-resident macrophages stem from the embryonal yolk sac and fetal liver.

Female carriers of the Apolipoprotein E4 (APOE4) allele have decreased risk for dementia.

Women with a lower birth weight are more likely to develop breast cancer later in life.

Birth-weight is negatively associated with breast cancer.

The mean suicide rate in women is lower after miscarriage than live birth.

The mean suicide rate in women is higher after miscarriage than live birth.

Female carriers of the Apolipoprotein E4 (APOE4) allele have shorter lifetime exposure to estrogen due to a decreased reproductive period.

Female carriers of the Apolipoprotein E4 (APOE4) allele have longer lifetime exposure to estrogen due to an increased reproductive period.

Excess gestational weight gain is associated with obesity-related pregnancy outcomes.

53% of perinatal mortality is due to low birth weight.


The risk of cancer rises with level of alcohol consumption.

In pediatric tissue, most T cells are naive T cell emigrants from the thymus.

Eliminating the last sporadic cases of malaria requires considerable funding.

Healthy volunteers exhibit rapid and transient increase of cellular ATP after being bolus-injected with fructose.

Smc5/6 engagment halts the activation of SUMO E3 ligase Mms21 by ATP-dependent remolding.

Genomic sequences involved in alternative splicing responsible for Hutchinson-Gilford progeria syndrome (HGPS) are abundant in the ''progerinonly'' allele of Lmna knock-in models.

Natriuretic peptides increase susceptibility to diabetes.

Activated Cdk5 regulates DNA damage-induced neuronal death.

Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection increases dissemination of Salmonella Typhimurium from the gut.

Oxidative phosphorylation is one of the primary glycometabolic pathways in cells.

Exercise reduces cancer mortality rates among Chinese citizens.

Exercise increases cancer mortality rates among Chinese citizens.

Participants who quit smoking reduce lung cancer risk by approximately 50%.

Pioglitazone use is significantly associated with an increased risk of pancreatic cancer.

Taking 400mg of α-tocopheryl acetate in combination with vitamin C reduces the risk of prostate cancer.

Pioglitazone use is significantly associated with an increased risk of prostate cancer.

Environmental factors can influence the development of breast cancer.


The risk of female prisoners harming themselves is ten times that of male prisoners.

AZT given with ribavirin increases anemia.

F4/80+ macrophages regulate mature osteoblast maintenance.

Piezo1 channels are sensors for cell migration in epithelial cells.

Egr3 regulates the homeostasis of B and T cells.

The density of cytokine receptor bearing cells has no effect on the distance over which cytokines act.

Charcoal shows no benefit for acute paraquat poisoning.

Persistor cells are one reason for incomplete responses to Tyrosine kinase inhibitor (TKI) therapy in cancer patients.

M. stadtmanae does not induce ASC speck formation in BlaER1 monocytes.

British female students are bullied more than British male students.

British male students are bullied more than British female students.

In the UK, drowning affects boys and girls equally.

Chlamydia trachomatis is most prevalent in the UK among sexually-experienced individuals aged 16 to 24.

Sildenafil worsens erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.

Women are more susceptible to death due to pneumonia when compared to men.

10% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.


The tip of the inner tube of the toxic type VI secretion system (T6SS) antibacterial effector in Escherichia coli (E. coli) is decorated with VgrG and PAAR proteins.

90% of patients with melanoma and an objective response to PD-1 blockade will experience a progression in their melanoma.

Normal expression of RUNX1 causes tumorsupressing effects.

The G34R/V mutation does not create a hypomethylated phenotype at the H3K36 histone.

Forkhead 0 (fox0) transcription factors are involved in cellular differentiation.

Tumor development occurs in conjunction with suppression of pro-inflammatory cytokines.

Whole brain radiotherapy increases the occurrence of new brain metastases.

Lmna knock-in models are appropriate for testing therapeutic approaches against Hutchinson-Gilford progeria syndrome (HGPS).

The DESMOND program demonstrates no significant impact on lifestyles outcomes.

The mean suicide rate in women is higher after miscarriage than live birth.

Tonic signaling from the scFv prevents constitutive stimulation.

VgrG (Tssl) protein punctures membranes by forming a spike at the tip of the tube apparatus.

During the primary early antibody response activated B cells migrate toward the inner-and outer follicular areas where oxysterol accumulation is generated by stromal cells.

Eilat virus (EILV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in nonhuman primates.

Citrullinated proteins externalized in neutrophil extracellular traps act indirectly to perpetuate the inflammatory cycle via induction of autoantibodies.

Nonhuman primates are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.

Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection increases dissemination of Salmonella Typhimurium from the gut.

Active H. pylori urease has a polymeric structure consisting of five distinct subunits.

β-sheet opening occurs during pleurotolysin pore formation.

The C-type lectin receptor (CLEC-2) rearranges the actin cytoskeleton in dendritic cells to promote efficient motility along stromal surfaces.


The tissue surrounding the granuloma in an immune cell induces an anti-inflammatory immune response.

Neutrophil extracellular trap (NET) antigens may contain the targeted autoantigens PR3 and MPO.

Lack of FGF21 in mice leads to reduced lifespan.

Students who perform poorly in the early years of medical school are less likely to commit professional misconduct later in their careers.

r-protein chaperones are found in complexes with their r-protein binding partners.

PD-1 triggering on monocytes enhances IL-10 production by monocytes.

Insulin decreases risk of severe kidney failure.

Bariatric surgery leads to negative outcomes in mental health.

Removal of H3K9me3 improves reprogramming efficiency in human somatic cell nuclear transfer experiments.

Ethanol stress reduces the expression of SRL in bacteria.

Microcin J25 encourages nucleoside triphosphate (NTP) binding.

Tuberculosis-induced granulomas express different immune system protein signatures than the surrounding tissue.

Inhibiting focal adhesion formation increases the rate at which cells convert mechanical strain into inflammation and fibrosis.

Cancer cells can stimulate the accumulation of intra-tumoural myeloid-derived suppressor cells by promoting granulocyte colony stimulating factor production.

Normal granulomas form in the presence of TNF in Zebrafish.

Normal granulomas form in the absence of TNF in Zebrafish.

Cancer-associated fibroblasts (CAFs) interact with cancer cells to mediate formation and activation of CAFs.

Cancer-associated fibroblasts (CAFs) have no known interaction with cancer cells in the formation and activation of CAFs.

Cancer-associated fibroblasts (CAFs) are constituents of tumor microenvironments

Increased flux of microbial products provokes immune responses.


Therapeutics receiving accelerated approval encounter a lower frequency of post-marketing safety events

Cholesterol loading induces KLF4 expression in VSMCs, resulting in the expression of pro-inflammatory cytokines.

Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection decreases dissemination of Salmonella Typhimurium from the gut.

Diabetic patients with acute coronary syndrome experience decreased short-term and long-term risk for bleeding events.

Cardiac tissue-resident macrophages directly contribute to electrical activity.

Individuals with Alzheimers who participate in six months of physical activity improve cognitive function for up to 18 months.

Charcoal shows no benefit for acute paraquat poisoning.

Reduction of purity of cytoplasmic membranes isolated from overexpressors is indicated by stronger spots for OmpA in 2D BN-PAGE gels.

Adult tissue-resident macrophages possess a self-renewing capacity.

Sympathetic nerve activity is elevated throughout normal pregnancy.

The most prevalent adverse events to Semaglutide are cardiovascular.

Side effects associated with antidepressants increases risk of stroke.

Side effects associated with antidepressants do not represent a mortality risk to postmenopausal women.

Taking anti-depresents is associated with a decrease in the Aβ level in the brain of experimental animals.

Including pharmacists in rounding teams does not alter the incidence of adverse drug events (ADEs).

Assessing treatment adherence is more beneficial to clinical practice than measuring routine outcomes.

Side effects associated with antidepressants lower risk of myocardial infarction.

Including pharmacists in rounding teams reduces the incidence of adverse drug events (ADEs).

Stroke patients with prior use of direct oral anticoagulants have a higher risk of in-hospital mortality than stroke patients with prior use of warfarin.


There is a positive correlation between hip fractures and statin use.

The appearance of brown-like or beige cells primarily occurs in visceral fat, not subcutaneous fat.

Immune complex triggered cell death leads to extracellular release of nuclear DNA.

ITAM phosphorylation allows for the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).

90% of patients with melanoma and an objective response to PD-1 blockade will experience a progression in their melanoma.

Omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegans.

Cancer-associated fibroblasts (CAFs) are constituents of tumor microenvironments

Osteocytes have an essential role in G-CSF induced HSPC mobilization.

Primary pro-inflammatory cytokines suppress secondary pro- and anti-inflammatory mediators.

Anthrax spores are very difficult to dispose once they are dispersed.

Noninvasive positive pressure ventilation is not predictive of acute respiratory failure after solid organ transplantation.

The peak incidence of fractures occurs in toddlers.

Surgical treatment is not superior to non-surgical in treating adults with displaced fractures of the proximal humerus.

The peak incidence of fractures occurs during pubertal growth spurt in early adolescents.

Scapular stabilizer exercises are more effective than general exercise therapy in reducing pain and improving function of the shoulder.

Rotator cuff exercises are more effective than general exercise therapy in reducing pain and improving function of the shoulder.

General exercise therapy is more effective than scapular stabilizer exercises in reducing pain and improving function of the shoulder.

General exercise therapy is more effective than rotator cuff exercises in reducing pain and improving function of the shoulder.

Sildenafil worsens erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.

Diabetes remission occurs less in people treated with conventional therapy than in people treated with laparoscopic adjustable gastric banding surgery.


There is a relation between Erythromycin use and hypertrophic pyloric stenosis.

Weighed food records (WFR) result in poor completion since they're costly to run and impose high participant burden.

Tirasemtiv has no effect on cardiac muscle.

Removal of H3K9me3 improves reprogramming efficiency in human somatic cell nuclear transfer experiments.

Headaches are correlated with cognitive impairment.

Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes epithelial damage.

Myelin sheaths are lipid-rich cellular structures.

A 100g dose of chloroquine chemoprophylactic regimen results in retinal toxicity after 5-6 years of weekly intake.

Bariatric surgery leads to negative outcomes in mental health.

There is no relation between Erythromycin use and hypertrophic pyloric stenosis.

The most prevalent adverse events to Semaglutide are gastrointestinal.

There is no increased risk of hypospadias with clomiphene.

Varenicline monotherapy is more effective after 26 weeks of treatment compared to combination nicotine replacement therapies with varenicline or bupropion.

The most prevalent adverse events to Semaglutide are cardiovascular.

Combination nicotine replacement therapies with varenicline or bupropion are more effective after 12 weeks of reatment compared to varenicline monotherapy.

Side effects associated with antidepressants increases risk of stroke.

Diabetes remission occurs more in people treated with conventional therapy than in people treated with laparoscopic adjustable gastric banding surgery.


There is no association between HNF4A mutations and diabetes risks.

MEK inhibitors are effective treatments in RAS-driven mouse models of cancer.

A low percentage of hematopoietic progenitor cells are susceptible to HIV-1 infection ex vivo.

Side effects associated with antidepressants do not represent a mortality risk to postmenopausal women.

BiP is a general endoplasmic reticulum stress marker.

HbA1c consistently overestimates glycemic control in black individuals with Sickle cell trait (SCT).

Reducing H3k4me3 methylation induces mouse epiblast stem cells to naive pluripotency efficiently.

Surgical treatment is not superior to non-surgical in treating adults with displaced fractures of the proximal humerus.

A high microerythrocyte count protects against severe anemia in homozygous alpha (+)- thalassemia trait subjects.

Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission.

Carriers of HNF4A mutations are at reduced risk for diabetes.

A mutation in HNF4A leads to an increased risk of developing diabetes by the age of 14 years.

HNF4A mutations are associated with macrosomia in infancy.

A mutation in HNF4A leads to an increased risk of diabetes by the age of 14 years.

A deficiency of vitamin B12 decreases blood levels of homocysteine.

The generation of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells.

In patients with congenital heart defects, β-blockers significantly improve clinical heart failure outcomes.

Autophagy deficiency in the liver increases vulnerability to insulin resistance.

Gpr124 increases BBB breakdown in mouse models of ischemic stroke.


There is no increased risk of hypospadias with clomiphene.

HSCT-T dosage may not be diagnostic if the onset of symptoms occurs less than 3 hours before AMI.

Autologous transplantation of mesenchymal stem cells has better graft function than induction therapy with anti-interleukin-2 receptor antibodies.

In S. cerevisiae, the absence of RNA surveillance pathways causes sensitivity to high iron conditions.

COPI coatmer is involved in lipid homeostasis.

MeCP2 influences the synaptic maturation of neurons.

Self-advocacy training is effective at decreasing homelessness.

Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 inhibit West Nile virus replication in cortical neurons.

Monoclonal antibody targeting of N-cadherin inhibits castration resistance.

Ly6C hi monocytes have a higher inflammatory capacity than Ly6C lo monocytes.

Many cytokines that are produced by cancer cells also contribute to carcinogenesis.

The most prevalent adverse events to Semaglutide are gastrointestinal.

Dexamethasone increases risk of postoperative bleeding.

Sildenafil worsens erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.

Varenicline monotherapy is more effective after 26 weeks of treatment compared to combination nicotine replacement therapies with varenicline or bupropion.

Higher plasma levels of I-carnitine, when associated with trimethylamine N-oxide, are negatively correlated with cardiovascular events in humans.

Higher plasma levels of I-carnitine, when associated with trimethylamine N-oxide, are positively correlated with cardiovascular events in humans.

Side effects associated with antidepressants lower risk of myocardial infarction.

Pioglitazone use is significantly associated with an increased risk of pancreatic cancer.


There is no known interaction between Pioneer factor OCT3/4 and major chromatin remodeling factors.

Pro-inflammatory cytokines are up regulated during tumor development.

The peak incidence of fractures occurs during pubertal growth spurt in early adolescents.

Up-regulation of the p53 pathway and related molecular events speeds cancer progression.

MUC1-C activates the NF-κB p65 signaling pathway by interacting with IκB kinase ß.

0-dimensional biomaterials lack inductive properties.

C2 works synergistically with A-769662 to activate dephosphorylated AMPK.

MafA phosphorylation decreases its ubiquitination.

There is a positive correlation between hip fractures and statin use.

The myocardial cell lineage originally develops from cardiac progenitors of exclusively endodermal origin.

The mean suicide rate in women is lower after miscarriage than live birth.

Pioneer factor OCT3/4 interacts with major chromatin remodeling factors.

The predominant localization of Linc00173 is in mononuclear macrophage nuclei.

CD44v6 is not associated with constitutive and reprogrammed cancer stem cells driving cancer metastasis.

CDK6 shows impaired binding to loss-of-function variants of p18 INK4C.

The PPR MDA5 has twenty N-terminal CARD domains.

CDK6 shows improved binding to loss-of-function variants of p18 INK4C.

Addition of BMP4, activin A, CHIR99021, and SU504 to reprogramming fibroblasts generates, expands and maintains cardiovascular progenitor cells (CPCs)

Replacement of OCT4 and SOX2 genes with GATA3 has the ability to reprogram human cells.


There is no relation between Erythromycin use and hypertrophic pyloric stenosis.

Decreased conversion of PGE 2 to PPARy ligand 15-ket-PGE 2 causes accumulation of PGE.

Medications to treat obesity are highly effective.

Diabetes remission occurs more in people treated with conventional therapy than in people treated with laparoscopic adjustable gastric banding surgery.

Kir7.1 modulates channel activity by the G protein-coupled melanocortin-4 receptor (MC4R) in the paraventricular nucleus of the hypothalamus.

Over half of the gabonese children with Schimmelpenning-Feuerstein-Mims syndrome (SFM) had a plasma lactate of more than 5mmol/L.

Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission.

Distant CREs are less conserved among species.

Induction of urokinase receptor signaling in podocytes causes foot process effacement and proteinuria.

The recruitment of Wdr5 to its target loci depends on Kat8.

Induced hepatic stem cells possess the potential to differentiate into hepatocytic cells.

There is a relation between Erythromycin use and hypertrophic pyloric stenosis.

There is no increased risk of hypospadias with clomiphene.

The most prevalent adverse events to Semaglutide are gastrointestinal.

Varenicline monotherapy is more effective after 26 weeks of treatment compared to combination nicotine replacement therapies with varenicline or bupropion.

The most prevalent adverse events to Semaglutide are cardiovascular.

Combination nicotine replacement therapies with varenicline or bupropion are more effective after 12 weeks of reatment compared to varenicline monotherapy.

Diabetes remission occurs less in people treated with conventional therapy than in people treated with laparoscopic adjustable gastric banding surgery.

Sildenafil worsens erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.


There was an estimated 30 million cases of pneumonia in young children worldwide in 2010.

IFIT1 speeds viral replication by allowing for the proliferation of mis-capped viral RNAs.

Pyridostatin prevents double-strand breaks accumulation.

The latent infection of myeloid cells with human cytomegalovirus induces a number of changes in gene expression.

Nonhuman primates are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.

Flexible molecules experience less steric hindrance in the tumor microenviroment than rigid molecules.

Primary cervical cytology screening with HPV detection has higher longitudinal sensitivity to detect severe cervical intraepithelial neoplasia than conventional cytology.

Gastric infection with Helicobacter pylori increases risk of gastric cancer in humans.

Mutations in RIM1 raise levels of IME1 RNA.

GATA3 regulates cell cycle progression in bone marrow hematopoietic stem cells.

10% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.

90% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.

Women are more susceptible to death due to pneumonia when compared to men.

Men are more susceptible to death due to pneumonia when compared to women.

Rising temperatures caused by global warming increases risk of dengue fever transmission.

Rising temperatures caused by global warming lowers the risk of dengue fever transmission.

Sepsis related mortality has risen from 2009 to 2014.

Tuberculosis incidence occurs at higher rates in more sparsely populated areas in the UK.

Approximately 250,000 people are infected with human T-cell lymphotropic virus type 1 in the United Kingdom.


Thiopurine active metabolites can be catabolized through dephosphorylation of thioguanine nucleotides.

Varying expression levels of EBI2 affect the positioning and migration of B cells.

Sequence conservation in gene regulatory regions between species is a high-accuracy predictor of conserved functionality.

MFGE8 regulates fat absorption by binding to av-Beta3 and av-Beta5 integrins.

The risk of cancer rises with level of alcohol consumption.

B3-Galectin decreases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR.

ScPif1p has higher binding ability to G-rich ssDNA than to non-G-rich ssDNA.

Women with a lower birth weight are more likely to develop breast cancer later in life.

ATM and Rad3 related protein have no role in sensing DNA damage.

H4 G94P proteins inhibit chromatin assembly, which decreases free histones.

ATM and Rad3 related protein are critical for sensing DNA damage.

Higher plasma levels of I-carnitine, when associated with trimethylamine N-oxide, are positively correlated with cardiovascular events in humans.

Higher plasma levels of I-carnitine, when associated with trimethylamine N-oxide, are negatively correlated with cardiovascular events in humans.

A breast cancer patient's capacity to metabolize tamoxifen influences treatment outcome.

Omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegetarians.

Omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegans.

The relationship between a breast cancer patient's capacity to metabolize tamoxifen and treatment outcome is independent of the patient's genetic make-up.

Active H. pylori urease has a polymeric structure consisting of five distinct subunits.

N348I mutations reduce resistance to nevirapine.

Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission.


Tirasemtiv has no effect on cardiac muscle.

The PRDM1 gene is a key determinant of primordial germ cells.

The proliferative capacity of progenitors is regulated cell-autonomously.

Whole brain radiotherapy increases the occurrence of new brain metastases.

Chronic HIV stimulation of B cells leads to the premature exhaustion of B cells.

One in two surgical randomized controlled trials are discontinued early.

Patients with common epithelial cancers are less likely to have an emergency event as their first hospital admission if they live in resource-deprived areas.

Mitochondria play a trivial role in calcium homeostasis.

Klf4 is not required for proper myeloid cell differentiation.

EGR2 is important to myelination of the peripheral nervous system.

Cardiac tissue-resident macrophages directly contribute to electrical activity.

Sudden death can occur in patients with orthostatic hypertension without cardiac conduction abnormalities.

Mice lacking Sirt1 in Sf1-expressing neurons have increased susceptibility to diet-induced obesity and insulin resistance.

Mice lacking Sirt1 in Sf1-expressing neurons are immune to diet-induced obesity and insulin resistance.

HSCT-T dosage may not be diagnostic if the onset of symptoms occurs less than 3 hours before AMI.

Egr2 regulates the homeostasis of B and T cells.


Early patent ductus ateriosus (PDA) screening increases in-hospital mortality.

The HSV-2 infection is typically asymptomatic.

Ethanol stress increases the expression of IBP in bacteria.

Misunderstandings between doctors and patients can lead to non-adherence.

Converting apoE4 to apoE3 by gene editing worsens the pathology associated with apoE4 in human iPSCderived neurons.

Gpr124 suppresses BBB breakdown in mouse models of ischemic stroke.

The risk of female prisoners harming themselves is ten times that of male prisoners.

PCSK9 inhibitors decrease plasma Lp(a) levels.

Human embryonic stem cells give rise to cell types from all three embryonic germ layers.

Mice lacking Sirt1 in Sf1-expressing neurons are immune to diet-induced obesity and insulin resistance.

Egr3 regulates the homeostasis of B and T cells.

CD28 signals regulate trafficking of murine auto-reactive T cells into target tissues.

Major antigen-induced signals from the T cell receptor and secondary signals from costimulatory receptors are required for T cell activation.

HIV trans-activator protein (TAT) effectively transports large and small molecules across cellular membranes into larger populations of neurons.


Traditional reviews are biased in their interpretations.

Upregulation of dynein in Drosophila neurons increases the number of microtubule plus-ends growing toward the cell body of each neuron.

Incidence of 10/66 dementia is higher than the incidence of DSM-IV dementia.

Chinese individuals with TT homozygosity in the MTHFR gene are more vulnerable to strokes caused by low levels of folate intake.

Birth-weight is negatively associated with breast cancer.

siRNA knockdown of A20 slows tumor progression in an in vivo murine xenograft model.

The risk of cancer rises with level of alcohol consumption.

A diminished ovarian reserve does not solely indicate infertility in an a priori non-infertile population.

Long chain polyunsaturated fatty acids supplementation reduces wheezing and asthma.

Gastric lavage is an effective treatment for acute paraquat poisoning.

IFI16 impedes STING phosphorylation and translocation, resulting in reduced activation of STING.

Foxk2 regulates autophagy genes in muscle cells and fibroblast cells.


Toll-like receptor (TLR) signaling is involved in the pathogenesis of human MDS.

Higher plasma levels of I-carnitine, when associated with trimethylamine N-oxide, are positively correlated with cardiovascular events in humans.

Deletion of ATM and Rad3 related protein leads to acute tissue loss.

Pyridostatin induces double-strand breaks accumulation.

GATA3 regulates self-renewal capacity in bone marrow hematopoietic stem cells.

IL-6 signaling plays a major role in atherosclerotic cardiovascular disease.

RAD52 is involved in break-induced DNA replication (BIR).

Primary cervical cancer screening with HPV detection has lower longitudinal sensitivity than conventional cytology to detect cervical intraepithelial neoplasia grade 2.

Human embryonic stem cells have the capacity to give rise to differentiated progeny representative of all three embryonic germ layers.

0-dimensional biomaterials lack inductive properties.

Gpr124 suppresses BBB breakdown in mouse models of ischemic stroke.

Certain immunomodulator-human dialyzable leukocyte extract (hDLE) peptides are recognized by toll-like receptors (TLRs) on macrophages and dendritic cells.

The PPR MDA5 has twenty N-terminal CARD domains.

Activated Cdk5 phosphorylates the ATM protein in response to DNA damage.

Dscam1 acts as a hypervariable pattern-recognition receptor for the immune system.

Gpr124 increases BBB breakdown in mouse models of ischemic stroke.


Tonic signaling from the scFv induces constitutive stimulation.

Pro-inflammatory cytokines are up regulated during tumor development.

Tonic signaling from the scFv is amplified by MyD88/CD40.

Glycan adaptation is rarely observed in the B-cell repertoire.

Distant CREs are important for transcriptional regulation.

The cytokine receptor which regulates chemotaxis and formation of lymph nodes is involved in production of myeloperoxidase in the left atrium.

Forkhead 0 (fox0) transcription factors are involved in cellular differentiation.

Taking 400mg of α-tocopheryl acetate in combination with vitamin C reduces the risk of prostate cancer.

Tuberculosis-induced granulomas express different immune system protein signatures than the surrounding tissue.

Incidence of heart failure increased by 10% in women since 1979.

Upon viral challenge, influenza-specific memory CD4+ T cells greatly diminish the early production of inflammatory chemokines in the lung.

Tonic signaling from the scFv prevents constitutive stimulation.

cSMAC formation represses weak ligand signalling.

Inhibiting focal adhesion formation increases the rate at which cells convert mechanical strain into inflammation and fibrosis.

CD28 initiates tonic signaling in conventional T cells, which causes an exhaustion phenotype and limited efficiency.

Ca2+ cycling is a UCP1-dependent thermogenic mechanism.

Guanine nucleotide exchange factors (GEFs) mediate RhoA activation in response to tensional forces on fibronectin-binding integrins.


Tonic signaling from the scFv is amplified by MyD88/CD40.

Sildenafil worsens erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants.

There is no increased risk of hypospadias with clomiphene.

C2 works synergistically with A-769662 to activate dephosphorylated AMPK.

Low expression of miR7a does not repress target genes or exert a biological function in testis.

Inhibiting HDAC6 increases survival of mice with ARID1A mutated tumors.

Induction of urokinase receptor signaling in podocytes causes foot process effacement and proteinuria.

Destination container port throughput(CPT) is negatively related to dengue virus (DENV-1) diffusion in air traffic shipments.

Environmentally-induced senescence is mimicked in disease modeling by adding specific molecules to the culture system.

M. stadtmanae does not induce ASC speck formation in BlaER1 monocytes.

Helminths interfere with immune system control of coinfections by microbial pathogens 16.

CD28 signals regulate trafficking of murine auto-reactive T cells into target tissues.

Activated Cdk5 regulates DNA damage-induced neuronal death.

Expression of MSX2 is induced 3 hours after the addition of BMP4, which is earlier than T and CDX2.


Tonic signaling from the scFv prevents constitutive stimulation.

L3MBTL2 binds to H2AK119Ub marked chromatin to form a PRC1 complex.

Localization of PIN1 in the roots of Arabidopsis requires VPS9a

There is no known interaction between Pioneer factor OCT3/4 and major chromatin remodeling factors.

There is a positive correlation between hip fractures and statin use.

Early patent ductus ateriosus (PDA) screening increases in-hospital mortality.

Concentrations of SNV and CNV in stem-cell regulatory elements and binding sites of transcription factors in iPSC-lines are distinct from their founding cells.

General exercise therapy is more effective than rotator cuff exercises in reducing pain and improving function of the shoulder.

Glycan adaptation is rarely observed in the B-cell repertoire.

Taking anti-depresents is associated with a decrease in the Aβ level in the brain of experimental animals.

HNF4A mutations are associated with macrosomia in infancy.

Inhibiting focal adhesion formation enables cells to convert mechanical strain into eventual scarring.

Allogeneic mechanical circulatory support is not as effective as autologous mechanical circulatory support for treating acute myocardial infarction.


Traditional reviews are biased in their interpretations.

Autologous transplantation of mesenchymal stem cells has better graft function than induction therapy with anti-interleukin-2 receptor antibodies.

Genes involved in pre-mRNA splicing have a significant impact on genome stability.

Omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegans.

Treatment with a protein named FN impairs regenerative abilities of aged muscles.

PrimPol generates short DNA replication intermediates on the leading strand during DNA replication.

Varying expression levels of EBI2 affect the positioning and migration of B cells.

Activator-inhibitor pairs are provided ventrally by Xrl-sizzled.

Medications to treat obesity have unwanted side effects.

Differentiation of progenitor cells to myeloid cells is skewed upon activation of insulin signaling.

H4 G94P proteins suppress degradation of free histones via Rad53-dependent mechanisms.

Misunderstandings between doctors and patients can lead to non-adherence.

Assessing treatment adherence is more beneficial to clinical practice than measuring routine outcomes.

Cost effectiveness evaluations based on cRCT data lack external validity.

Measuring routine outcomes is more beneficial to clinical practice than assessing treatment adherence.

Students who perform poorly in the early years of medical school are less likely to commit professional misconduct later in their careers.

Students who perform poorly in the early years of medical school are at increased risk for professional misconduct later in their careers.

Cost effectiveness evaluations based on cRCT data accurately reflect prices for patients in actual clinical practice.

Weighed food records (WFR) result in poor completion since they're costly to run and impose high participant burden.

British male students are bullied more than British female students.


Trans-acting factors, such as lncRNAs, influence mRNA translation.

Radioiodine treatment of non-toxic multinodular goitre increases thyroid volume.

The peak incidence of fractures occurs during pubertal growth spurt in early adolescents.

Taxation of sugar-sweetened beverages reduced the incidence rate of type II diabetes in India.

Satellite cell dysfunction is a key factor in sarcopenia development.

The predominant localization of Linc00173 is in mononuclear macrophage nuclei.

HSCT-T dosage may not be diagnostic if the onset of symptoms occurs less than 3 hours before AMI.

The World Health Organization's (WHO) data collection process is biased downward by unequal selection of larger outbreaks.

Upon developing tyrosine-kinase inhibitor resistance, new mutations in epidermal growth factor receptors emerge and cause treatment failure.

61% of colorectal cancer patients are diagnosed with regional or distant metastases.

The mean suicide rate in women is higher after miscarriage than live birth.

Cis-acting lncRNAs control the expression of genes that are positioned in the vicinity of their transcription sites.

Genes involved in pre-mRNA splicing have a significant impact on genome stability.

Long - range chromatin interactions regulate transcription.

Pre-mRNAs associated with spliceosomal components are less stable than unassociated splicing substrates.

Pre-mRNAs associated with spliceosomal components are more stable than unassociated splicing substrates.

miRNAs regulate a unique suite of mRNAs to maintain homeostasis in cells.

miRNAs enforce homeostasis by suppressing low-level ''leaky'' transcription.

Recognition of start codons depends on the translation initiation factor IF3.

Post-transcriptional handling of mitochondrial transcripts occurs in mitochondrial RNA granules.


Transcription factor EB induces transcription of pro-inflammatory cytokines in macrophages infected with Staphylococcus aureus.

Persistor cells are one reason for incomplete responses to Tyrosine kinase inhibitor (TKI) therapy in cancer patients.

Overexpressing Cnp1 N-tail variants exacerbates the temperature-sensitive growth defect of scm3-139.

Many cytokines that are produced by cancer cells also contribute to carcinogenesis.

Sn is present on mature DCs during inflammation in vivo.

Origin gross domestic product(GDP) is positively related to dengue virus (DENV-1) diffusion in air traffic shipments.

The amount of publicly available DNA data doubles every 10 months.

Healthy volunteers exhibit rapid and transient increase of cellular ATP after being bolus-injected with fructose.

KRT17 modulates the expression of the transcriptional regulator AIRE in diseased epithelia.

Upon viral challenge, influenza-specific memory CD4+ T cells greatly enhance the early production of inflammatory chemokines in the lung.

Upon viral challenge, influenza-specific memory CD4+ T cells greatly diminish the early production of inflammatory chemokines in the lung.

Eilat virus (EILV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in nonhuman primates.

The latent infection of myeloid cells with human cytomegalovirus induces a number of changes in gene expression.

Ethanol stress increases the expression of IBP in bacteria.

MUC1-C activates the NF-κB p65 signaling pathway by interacting with IκB kinase ß.

Mice that lack Interferon-γ or its receptor are highly susceptible to experimental autoimmune myocarditis.

The DdrB protein from Deinococcus radiodurans functions as a pentamer.


Transcription rates in S. cerevisiae range between 0.7 and 2 kb/min.

Patients with common epithelial cancers  are more likely to have an emergency event as their first hospital admission if they live in resource-deprived areas.

Mutations in RIM1 raise levels of IME1 RNA.

Ethanol stress increases the expression of SRL in bacteria.

Surfactin producing cells and exopolymer producing cells cooperate to generate "Van Gogh" bundles that have sliding abilities on specialized media.

Normal expression of RUNX1 causes tumorsupressing effects.

Specialized functional cell types can be derived from human pluripotent stem cells.

IgA plasma cells that are specific for transglutaminase 2 are scarce in the duodenal mucosa of celiac disease patients when the disease is active.

A diminished ovarian reserve does not solely indicate infertility in an a priori non-infertile population.

Human embryonic stem cells have the capacity to give rise to differentiated progeny representative of all three embryonic germ layers.

Transcription rates in S. cerevisiae range between 7 and 12 kb/min.

Glucose restriction to 0.05% reduces RLS (replicative life span) by 20-40% in S. cerevisiae.

Genes involved in pre-mRNA splicing have a significant impact on genome stability.

Cellular differentiation of embryonic stem cells is accompanied by changes in replication timing, transcription and nuclear localization.

miRNAs enforce homeostasis by suppressing low-level ''leaky'' transcription.

Pre-mRNAs associated with spliceosomal components are more stable than unassociated splicing substrates.

Pre-mRNAs associated with spliceosomal components are less stable than unassociated splicing substrates.


Transcription rates in S. cerevisiae range between 7 and 12 kb/min.

Intramembrane cleavage by signal peptide peptidase aids in the degradation of proteins with a complex membrane orientation.

Bariatric surgery reduces colorectal cancer.

Chlamydia trachomatis is most prevalent in the UK among individuals in their 50s and 60s.

Interleukin-18 plays an important role in the pathogenesis of atherosclerosis.

Decreased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm.

Physical activity level is associated with the difference in maximal oxygen consumption between black and white youth.

Cancer-associated fibroblasts (CAFs) are constituents of tumor microenvironments

Bariatric surgery reduces postmenopausal breast cancer.

CD28 signals regulate trafficking of murine auto-reactive T cells into target tissues.

Recognition of start codons depends on the translation initiation factor IF3.

Post-transcriptional handling of mitochondrial transcripts occurs in mitochondrial RNA granules.