Integrated care is successful at tackling multiple comorbidities.

Scapular stabilizer exercises are more effective than general exercise therapy in reducing pain and improving function of the shoulder.

Replacement of histone H2A with H2A.Z accelerates gene activation in yeasts by destabilizing +1 nucleosomes.

TRAP+ osteoclasts regulate mature osteoblast maintenance.

Assessing treatment adherence is more beneficial to clinical practice than measuring routine outcomes.

Microglia are an innate immune cell type of the central nervous system.

A 100g dose of chloroquine chemoprophylactic regimen results in retinal toxicity after 1 year of weekly intake.

Egr3 regulates the homeostasis of B and T cells.

Metastatic colorectal cancer treated with a single agent fluoropyrimidines resulted in similar efficacy and better quality of life when compared with oxaliplatin-based chemotherapy in elderly patients.

The risk of female prisoners harming themselves is ten times that of male prisoners.

The DESMOND program demonstrates no significant impact on biochemical outcomes.

Risk-adjusted mortality rates are similar in teaching and non-teaching hospitals.

Bariatric surgery leads to positive outcomes in mental health.


Integrating classroom-based collaborative learning with Web-based collaborative learning offers the best class performance.

B cells go though plasmablast differentiation and antibody production by continuous expression of EBI2.

Homozygous deletion of murine Sbds gene from osterix-expressing mesenchymal stem and progenitor cells (MPCs) induces oxidative stress.

Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 encourage West Nile virus replication in cortical neurons.

Immune responses in immune cells are geographically segregated.

Long - range chromatin interactions regulate transcription.

Omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegetarians.

There is no relation between Erythromycin use and hypertrophic pyloric stenosis.

Overexpressing Cnp1 N-tail variants exacerbates the temperature-sensitive growth defect of scm3-139.

The composition of myosin-II isoform switches from the A isoform to the B isoform during hematopoietic differentiation.

Integrated care is successful at tackling multiple comorbidities.

Integrated care is ineffective at tackling multiple comorbidities.

Measuring routine outcomes is more beneficial to clinical practice than assessing treatment adherence.

Cost effectiveness evaluations based on cRCT data lack external validity.

Self-advocacy training is effective at decreasing homelessness.

Assessing treatment adherence is more beneficial to clinical practice than measuring routine outcomes.

Cost effectiveness evaluations based on cRCT data accurately reflect prices for patients in actual clinical practice.

Having a main partner improves HIV outcomes.

7-day-old adult Caenorhabditis elegans exhibit approximately 75% of the learning capacity seen in 1-day old adults.


Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 encourage West Nile virus replication in cortical neurons.

Lice attenuated SIV vaccines induce a stronger antigen-specific T cell response in lymph node cells.

Autophagy deficiency in the liver increases vulnerability to insulin resistance.

Insulin decreases risk of severe kidney failure.

Inhibiting focal adhesion formation increases the rate at which cells convert mechanical strain into inflammation and fibrosis.

V-9302 inhibits antitumor responses by decreasing cell death and oxidative stress.

Chinese individuals with TT homozygosity in the MTHFR gene are less vulnerable to strokes caused by low levels of folate intake.

Early patent ductus ateriosus (PDA) screening increases in-hospital mortality.

FACT and other histone chaperone(s) compensate for Histone 2A (H2A)-histone 2B (H2B) dimer eviction during the histone exchange process.

Kir7.1 modulates channel activity by the G protein-coupled melanocortin-4 receptor (MC4R) in the paraventricular nucleus of the hypothalamus.

A high microerythrocyte count protects against severe anemia in homozygous alpha (+)- thalassemia trait subjects.

Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 inhibit West Nile virus replication in cortical neurons.

Eilat virus (EILV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in nonhuman primates.

Nonhuman primates are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.

The deamination of cytidine to uridine on the minus strand of viral DNA can inactivate the viral genome by inducing G-to-A mutations.

The latent infection of myeloid cells with human cytomegalovirus induces a number of changes in gene expression.

Commelina yellow mottle virus (ComYMV) has three typical badnavirus ORFs, capable of encoding proteins 23, 15, and 216 kD.

Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection decreases dissemination of Salmonella Typhimurium from the gut.

Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection increases dissemination of Salmonella Typhimurium from the gut.

Neutrophils produce IL-1β in response to large particles.


Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 inhibit West Nile virus replication in cortical neurons.

Oxidative DNA damage activates STING signalling.

0-dimensional biomaterials lack inductive properties.

ART has no effect on the infectiveness of HIV-positive people.

Systemic lupus erythematosus is a risk factor for cardiovascular disease.

COPI coatmer is involved in viral replication.

Rhythmic expression of Cry1 translates directly into a circadian regulation of cAMP signaling in hepatic glucose metabolism.

Major antigen-induced signals from the T cell receptor and secondary signals from costimulatory receptors are required for T cell activation.

Participants who quit smoking reduce lung cancer risk by approximately 50%.

Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 encourage West Nile virus replication in cortical neurons.

Phase information is useful for predicting donor-recipient matches in organ transplantation.

Bacteriophagaes MS2 and Qβ are members of the Leviviridae.


Interleukin-18 plays an important role in the pathogenesis of atherosclerosis.

A deficiency of folate increases blood levels of homocysteine.

In S. cerevisiae, the absence of RNA surveillance pathways reduces sensitivity to high iron conditions.

HIV trans-activator protein (TAT) effectively transports large and small molecules across cellular membranes into larger populations of neurons.

Stroke patients with prior use of direct oral anticoagulants have a higher risk of in-hospital mortality than stroke patients with prior use of warfarin.

Walking in traffic areas in London did not improve lung function in elderly adults.

H4 G94P proteins induce degradation of free histones via Rad53-dependent mechanisms.

Having a main partner worsens HIV outcomes.

General exercise therapy is more effective than rotator cuff exercises in reducing pain and improving function of the shoulder.

Repressing IL-18 has negative effects on atherosclerotic lesion composition and progression.

Reduced responsiveness to interleukin-2 in regulatory T cells is associated with autoimmune diseases such as Type 1 Diabetes.

IL-6 signaling plays a major role in atherosclerotic cardiovascular disease.

p16INK4A degradation is  linked to an abnormal wound response caused by the microinvasive step of advanced Oral Potentially Malignant Lesions (OPMLs).

KRT17 modulates the expression of the transcriptional regulator AIRE in diseased epithelia.

The NF-κB essential modulator gene induces intestinal inflammation by promoting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death.

Osteoparthritis (OA) is characterized by degeneration of articular cartilage, joint edge, and subchondral bone hyperplasia.

The NF-κB essential modulator gene prevents intestinal inflammation by inhibiting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death.

Two variants of chromosome 6q21 are associated with radiation therapy-induced second malignancies in pediatric Hodgkin lymphoma patients.


Intra-cerebroventricular infusion of amyloid-β oligomers increases expression of fibronectin type-III domain-containing protein 5 mRNA in mice hippocampi.

Mice that lack Interferon-γ or its receptor are highly susceptible to experimental autoimmune myocarditis.

Increase of p62 in prostate tumor stroma results in defective autophagy.

AMP-activated protein kinase (AMPK) activation reduces inflammation-related fibrosis in the lungs.

Natriuretic peptides protect against diabetes.

Asymptomatic visual impairment screening in elderly populations leads to improved vision.

Physical activity level has no association with the difference in maximal oxygen consumption between black and white youth.

Clathrin stabilizes the spindle fiber apparatus during mitosis.

Normal granulomas form in the presence of TNF in Zebrafish.

Decreased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm.

Intra-cerebroventricular infusion of amyloid-β oligomers reduces expression of fibronectin type-III domain-containing protein 5 mRNA in mice hippocampi.

Guanine nucleotide exchange factors (GEFs) mediate RhoA activation in response to tensional forces on fibronectin-binding integrins.

Upregulation of dynein in Drosophila neurons increases the number of microtubule plus-ends growing toward the cell body of each neuron.

Fibroblast growth factor 21 protects against atherosclerosis by modulating adiponectin and SREBP2 levels.

Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes fibrosis.

Gpr124 increases BBB breakdown in mouse models of ischemic stroke.

The C-type lectin receptor (CLEC-2) rearranges the actin cytoskeleton in dendritic cells to promote efficient motility along stromal surfaces.

Inhibiting glucose-6-phospate dehydrogenase improves lipogenesis by deactivating LKB1-AMPK signaling.


Intra-cerebroventricular infusion of amyloid-β oligomers reduces expression of fibronectin type-III domain-containing protein 5 mRNA in mice hippocampi.

Dscam1 acts as a hypervariable pattern-recognition receptor for the immune system.

T cell receptor /CD3 microdomains are required to induce the immunologic synapse.

CDK6 shows improved binding to loss-of-function variants of p18 INK4C.

The gene daf-16, which encodes forkhead Box O (FOXO), is required for all phenotypes associated with reduced insulin/insulin-like growth factor (Igf) signaling.

Sudden death can occur in patients with complex ventricular arrhythmias.

Birth-weight is negatively associated with breast cancer.

Reduced phosphorylation of PP2A suppresses HDAC4 dephosphorylation.

The mean suicide rate in women is higher after miscarriage than live birth.

Natriuretic peptides increase susceptibility to diabetes.

Removal of H3K9me3 by ectopic expression of other H3K9 demethylases decreases reprogramming efficiency in SCNT experiments.

Gpr124 suppresses BBB breakdown in mouse models of ischemic stroke.

IL-6 signaling plays a major role in atherosclerotic cardiovascular disease.


Intramembrane cleavage by signal peptide peptidase aids in the degradation of proteins with a complex membrane orientation.

High levels of CRP lead to a higher risk of exacerbations in chronic obstructive pulmonary disease (COPD).

BiP is a general endoplasmic reticulum stress marker.

There was an estimated 30 million cases of pneumonia in young children worldwide in 2010.

Two variants of chromosome 6q21 are associated with radiation therapy-induced second malignancies in pediatric Hodgkin lymphoma patients.

The HSV-2 infection is typically asymptomatic.

Trans-acting factors, such as lncRNAs, influence mRNA translation.

Having a main partner worsens HIV outcomes.

Mice without IFN-γ or its receptor are highly susceptible to EAM induced with α-MyHC/CFA.

Surfactin producing cells and exopolymer producing cells cooperate to generate "Van Gogh" bundles that have sliding abilities on specialized media.

Klf4 is important for proper myeloid cell differentiation.

Many transmembrane receptors transmit signals by long-range conformational changes in the association of alpha-helices across the plasma membrane.

The microtubule-dependent delivery and secretion of matrix metalloproteases (MMPs) is partially responsible for the disassembly of adhesion sites.

Ly49Q directs the organization of neutrophil polarization by regulating membrane raft functions.

VgrG (Tssl) protein punctures membranes by forming a spike at the tip of the tube apparatus.

Stiff substrates encourage mesodermal differentiation by degrading beta-catenin in an integrin-dependent manner.

Lamins have no effect on nuclear membrane structure maintenance.

r-protein chaperones are found in complexes with their r-protein binding partners.

Lamins are associated with nuclear membrane structure maintenance.

Reduction of purity of cytoplasmic membranes isolated from overexpressors is indicated by stronger spots for OmpA in 2D BN-PAGE gels.


It is not proven that moderate consumption of candy and chocolate reduces the risk of cardiovascular disease (CVD) specifically.

Environmental factors can influence the development of breast cancer.

r-protein chaperones are found in complexes with their r-protein binding partners.

Tonic signaling from the scFv is amplified by MyD88/CD40.

Bariatric surgery reduces colorectal cancer.

ATF4 is a general endoplasmic reticulum stress marker.

Gastric lavage is an effective treatment for acute paraquat poisoning.

Sequence conservation in gene regulatory regions between species is a poor predictor of conserved functionality.

Ribosomopathies have a high degree of cell and tissue specific pathology.

In S. cerevisiae, the absence of RNA surveillance pathways reduces sensitivity to high iron conditions.

Physical activity does not improve cognitive function in individuals with Alzheimers.

Moderate consumption of candy and chocolate reduces the risk of cardiovascular disease (CVD).

Consumption of whole fruits increases the risk of type 2 diabetes.

Taxation of sugar-sweetened beverages reduced the incidence rate of type II diabetes in India.

Medications to treat obesity have unwanted side effects.

LDL cholesterol has a causal role in the development of cardiovascular disease.

Medications to treat obesity do not have side effects.

In young and middle-aged adults, current or remote uses of ADHD medications increase the risk of serious cardiovascular events.

Autophagy deficiency in the liver increases vulnerability to insulin resistance.

Medications to treat obesity are highly effective.


JMJD6 catalyzes the hydroxylation of C-terminal lysine and supresses transcriptional activity.

During the primary early antibody response activated B cells migrate toward the inner-and outer follicular areas where oxysterol accumulation is generated by stromal cells.

The latent infection of myeloid cells with human cytomegalovirus induces a number of changes in gene expression.

MeCP2 influences the synaptic maturation of neurons.

Anthrax spores remain deadly until affected areas are decontaminated.

Risk of cardiovascular events can be cut by a third by using antihypertensive drug therapy among hemodialysis patients.

Microglia are an innate immune cell type of the peripheral nervous system.

The recruitment of Wdr5 to its target loci depends on Kat8.

LSD1-positive promoters are associated with RNA polymerase II

Intake of folic acid (FA) and vitamin B6 (VB6) increases levels of homocysteine.

JMJD6 slows the hydroxylation of C-terminal lysine

Activated Cdk5 phosphorylates the ATM protein in response to DNA damage.

Smc5/6 engagment halts the activation of SUMO E3 ligase Mms21 by ATP-dependent remolding.

Activated Cdk5 regulates DNA damage-induced neuronal death.

Active caspase-11 participate in regulating phagosome-lysosome fusion.

Binding of p53 to enhancer regions (p53BERs) regulates the activity of p53 transcription and cell cycle arrest through the production of p53-dependent eRNAs.

ITAM phosphorylation allows for the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).


JMJD6 slows the hydroxylation of C-terminal lysine

F4/80+ macrophages regulate mature osteoblast maintenance.

Rising temperatures caused by global warming lowers the risk of dengue fever transmission.

Prescribed exercise training improves quality of life.

Assessing treatment adherence is more beneficial to clinical practice than measuring routine outcomes.

The DdrB protein from Deinococcus radiodurans functions as a pentamer.

Intra-cerebroventricular infusion of amyloid-β oligomers increases expression of fibronectin type-III domain-containing protein 5 mRNA in mice hippocampi.

Blocking the interaction between TDP-43 and respiratory complex I proteins ND3 and ND6 prevents TDP-43-induced neuronal loss.

qSOFA scores are associated with length of stay in emergency department patients.

Cancer-associated fibroblasts (CAFs) are constituents of tumor microenvironments

Trans-acting factors, such as lncRNAs, influence mRNA translation.

Formation of N-terminal pyroglutamate by glutamine cyclase (GC) competes with NTAQ1 for Nt-Gln substrates.

Active Ly49Q induces neutrophil polarization.

Removal of H3K9me3 by ectopic expression of other H3K9 demethylases improves reprogramming efficiency in SCNT experiments.

Removal of H3K9me3 by ectopic expression of other H3K9 demethylases decreases reprogramming efficiency in SCNT experiments.

Ly49Q directs the organization of neutrophil polarization by regulating membrane raft functions.

C2 works synergistically with A-769662 to activate dephosphorylated AMPK.

Active Ly49Q prevents neutrophil polarization.


KLF4 is necessary for VSMCs to gain genetic characteristics of other cell types within atherosclerotic lesions.

Mitochondria play a major role in energy production.

Physical activity level has no association with the difference in maximal oxygen consumption between black and white youth.

HbA1c consistently overestimates glycemic control in black individuals with Sickle cell trait (SCT).

Sudden death can occur in patients with complex ventricular arrhythmias.

Environmentally-induced senescence is mimicked in disease modeling by adding specific molecules to the culture system.

Over half of the gabonese children with Schimmelpenning-Feuerstein-Mims syndrome (SFM) had a plasma lactate of more than 5mmol/L.

Ribosomal protein (RP) expression is controlled in part by stress-activated regulators.

Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission.

Rising temperatures caused by global warming increases risk of dengue fever transmission.

The minor G allele of FOXO3 downregulates pro-inflammatory cytokines.

Cholesterol loading induces KLF4 expression in VSMCs, resulting in the expression of pro-inflammatory cytokines.

CD44v6 is not associated with constitutive and reprogrammed cancer stem cells driving cancer metastasis.

Klf4 is not required for proper myeloid cell differentiation.

Klf4 is important for proper myeloid cell differentiation.

G-CSF increases the expansion and infiltration of MDSCs into tumors.

Cancer-associated fibroblasts (CAFs) have no known interaction with cancer cells in the formation and activation of CAFs.

Sn is present on mature DCs during inflammation in vivo.

Ly6C hi monocytes have a higher inflammatory capacity than Ly6C lo monocytes.

Klf2 is important for proper myeloid cell function.


KRT17 modulates the expression of the transcriptional regulator AIRE in diseased epithelia.

Diminished ovarian reserve is a reliable indicator of infertility in a non-infertile population.

61% of colorectal cancer patients are diagnosed with regional or distant metastases.

Ethanol stress lowers the expression of PSP in bacteria.

Sepsis related mortality has remained stable between 2009-2014.

The DESMOND program demonstrates no significant impact on weight loss.

Migraine with aura is associated with ischemic stroke.

At least 85% of patients exposed to radiation have activated markers of myofibroblasts.

Taking 400mg of α-tocopheryl acetate in combination with vitamin C reduces the risk of prostate cancer.

The DESMOND program caused substantial weight loss in most participants.

The RANK-RANK-Ligand (RANKL) pathway is involved in the development of Aire-expressing medullary thymic epithelial cells (mTECs).

Transcription factor EB induces transcription of pro-inflammatory cytokines in macrophages infected with Staphylococcus aureus.

ITAM phosphorylation allows for the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).

RANK-RANKL pathway signalling has no known association with development of Aire-expressing medullary thymic epithelial cells.

IFI16 impedes STING phosphorylation and translocation, resulting in reduced activation of STING.

TNFAIP3 is a glioblastoma tumor suppressor.

RANK-RANKL pathway signalling is linked to development of Aire-expressing medullary thymic epithelial cells.

Interleukin-18 plays an important role in the pathogenesis of atherosclerosis.

Foxp3 enables the expression of transcriptional regulators implicated in memory T cell development.


Kir7.1 modulates channel activity by the G protein-coupled melanocortin-4 receptor (MC4R) in the paraventricular nucleus of the hypothalamus.

The DESMOND program demonstrates no significant impact on biochemical outcomes.

There was an estimated 30 million cases of pneumonia in young children worldwide in 2010.

Tuberculosis-induced granulomas express different immune system protein signatures than the surrounding tissue.

MT binding domain drives amyloid structure formation.

Microglia are an innate immune cell type of the central nervous system.

RANK-RANKL pathway signalling is linked to development of Aire-expressing medullary thymic epithelial cells.

Helicobacter pylori-induced aberrant NF-kB-dependent expression of activation-induced cytidine deaminase contributes to the mutagenesis of host DNA.

Ly49Q directs the organization of neutrophil polarization by regulating membrane raft functions.

Guanine nucleotide exchange factors (GEFs) mediate RhoA activation in response to tensional forces on fibronectin-binding integrins.

Formation of N-terminal pyroglutamate by glutamine cyclase (GC) competes with NTAQ1 for Nt-Gln substrates.

The C-type lectin receptor (CLEC-2) rearranges the actin cytoskeleton in dendritic cells to promote efficient motility along stromal surfaces.

B3-Galectin decreases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR.

B3-Galectin increases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR.

The PPR MDA5 has twenty N-terminal CARD domains.

The NF-κB essential modulator gene induces intestinal inflammation by promoting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death.


Klf2 is important for proper myeloid cell function.

Anthrax spores remain deadly until affected areas are decontaminated.

During non-homologous end joining, the ligation step is not as tolerant of disrepairs and other distortions when joining 3' of strand breaks as compared to 5' strand breaks.

Inside the body, falciparum parasites reproduce asexually.

CD28 initiates tonic signaling in conventional T cells, which causes an exhaustion phenotype and limited efficiency.

Expression of oncolytic virus antigens as peptides makes relapse more likely.

Taxation of sugar-sweetened beverages reduced the incidence rate of type II diabetes in India.

Chinese individuals with TT homozygosity in the MTHFR gene are more vulnerable to strokes caused by low levels of folate intake.

Splenomegaly is observed in knockin mouse lacking the SHP-2 MAPK pathway.

B3-Galectin increases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR.

Vaccinating the gastrointestinal tract induces protection of rectal and vaginal mucosa.

Klf4 is important for proper myeloid cell differentiation.

Klf4 is not required for proper myeloid cell differentiation.

Differentiation of progenitor cells to myeloid cells is skewed when insulin signaling is suppressed.

Differentiation of progenitor cells to myeloid cells is skewed upon activation of insulin signaling.

The cytokine receptor which regulates chemotaxis and formation of lymph nodes is involved in production of myeloperoxidase in the left atrium.

Osteocytes have an essential role in G-CSF induced HSPC mobilization.

Bone Marrow (BM) transplantation is used to treat acute myeloid leukemia (AML)

Foxk2 regulates autophagy genes in muscle cells and fibroblast cells.

The latent infection of myeloid cells with human cytomegalovirus induces a number of changes in gene expression.


Klf4 is important for proper myeloid cell differentiation.

Post-transcriptional handling of mitochondrial transcripts occurs in mitochondrial RNA granules.

Bariatric surgery leads to negative outcomes in mental health.

61% of colorectal cancer patients are diagnosed with regional or distant metastases.

Broadly HIV-1 Neutralizing Antibodies (bnAb) 10EB have no affinity for phospholipids.

Treatment with a protein named FN impairs regenerative abilities of aged muscles.

Side effects associated with antidepressants do not represent a mortality risk to postmenopausal women.

ScPif1p has higher binding ability to G-rich ssDNA than to non-G-rich ssDNA.

Increased purity of cytoplasmic membranes isolated from overexpressors is indicated by stronger spots for OmpF in 2D BN-PAGE gels.

C2 works synergistically with A-769662 to activate dephosphorylated AMPK.

HOXB4 facilitates HSC expansion when co-cultured with HSCs.

HOXB4 is a highly expressed component of cellular secretome from fetal liver cell populations.


Klf4 is not required for proper myeloid cell differentiation.

Citrullinated proteins externalized in neutrophil extracellular traps act indirectly to disrupt the inflammatory cycle.

Charcoal shows no benefit for acute paraquat poisoning.

Increased conversion of PGE 2 to PPARy ligand 15-ket-PGE 2 causes accumulation of PGE.

Patients in stable partnerships progress from HIV to death at the same rate as patients not in partnerships.

PCSK9 inhibitors decrease plasma Lp(a) levels.

Tonic signaling from the scFv induces constitutive stimulation.

British male students are bullied more than British female students.

Increased vessel density along with a reduction in fibrosis improves the efficacy of chemotherapy treatments.

H4 G94P proteins inhibit chromatin assembly, which decreases free histones.

MICAL redox enzymes regulate actin dynamics in many cell types.

Differentiated E2f-1, -2, -3 TKO cells in the intestine do not exhibit apoptosis.

HNF4A mutations are associated with macrosomia in infancy.

Bone marrow cells don't contribute to adult macrophage compartments.


Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes epithelial damage.

The myocardial cell lineage originally develops from cardiac progenitors of exclusively endodermal origin.

Pyridostatin decreases telomere fragility in BRCA2-deficient cells.

Tonic signaling from the scFv is amplified by MyD88/CD40.

Forkhead 0 (fox0) transcription factors are involved in cellular differentiation.

Vaccinating the gastrointestinal tract induces protection of rectal and vaginal mucosa.

The PRDM1 gene, when combined with the PRDM14 gene, plays an important role during primordial germ cell specification.

The cytokine receptor which regulates chemotaxis and formation of lymph nodes is involved in production of myeloperoxidase in the left atrium.

Clathrin stabilizes the spindle fiber apparatus during mitosis.

Overexpressing Cnp1 N-tail variants exacerbates the temperature-sensitive growth defect of scm3-139.

Bariatric surgery increases rates of colorectal cancer.

Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes fibrosis.

ITAM phosphorylation allows for the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).

TNFAIP3 is a tumor enhancer in glioblastoma.

TNFAIP3 is a glioblastoma tumor suppressor.

Deletion of ATM and Rad3 related protein leads to acute tissue loss.

TNFAIP3 is a glioblastoma tumor enhancer.

ALDH1 expression is associated with poorer prognosis for breast cancer primary tumors.

aPKCz causes tumour suppression by affecting glutamine metabolism.

Mutations in G-Beta protein GNB1 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.


Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes fibrosis.

Long chain polyunsaturated fatty acids supplementation is associated with lower rates of atopic eczema at 1 year.

Exercise reduces cancer mortality rates among Chinese citizens.

Treatment with the EC uptake inhibitor AM404 resulted in a dose-dependent decrease in the expression of immobility.

β-sheet opening occurs during pleurotolysin pore formation.

Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection increases dissemination of Salmonella Typhimurium from the gut.

The World Health Organization's (WHO) data collection process is biased downward by unequal selection of larger outbreaks.

Exposure to fine particulate air pollution is unrelated to anxiety prevalence.

Inside the body, falciparum parasites reproduce asexually.

Mice without IFN-γ or its receptor are highly susceptible to EAM induced with α-MyHC/CFA.

AZT given with ribavirin increases anemia.

AMP-activated protein kinase (AMPK) activation reduces inflammation-related fibrosis in the lungs.

Lack of FGF21 in mice leads to atherosclerotic plaque formation.

Lack of FGF21 in mice slows the rate of atherosclerotic plaque formation.


L3MBTL2 binds to H2AK119Ub marked chromatin to form a PRC1 complex.

Systemic immunosuppressive (IS) therapy increases the chance of cancer mortality in patients with inflammatory eye disease (IED)

There is a relation between Erythromycin use and hypertrophic pyloric stenosis.

Differentiation of progenitor cells to myeloid cells is skewed when insulin signaling is suppressed.

Medications to treat obesity have unwanted side effects.

taa1 tar1 tar2 triple mutants in Arabidopsis do not make root meristem during embryogenesis.

Genomic sequences involved in alternative splicing responsible for Hutchinson-Gilford progeria syndrome (HGPS) are abundant in the ''progerinonly'' allele of Lmna knock-in models.

ERAP1 SNPs are epistatic to HLA alleles for ankylosing spondylitis.

Sepsis related mortality has remained stable between 2009-2014.

Increase of p62 in prostate tumor stroma results in defective autophagy.

Patients with panic anxiety show decreased CSF levels of hypocretin.

PRC1-bound plasmids sediment at a slower rate in unbound plasmids than in sucrose gradients.

H4 G94P proteins inhibit chromatin assembly, which decreases free histones.

CCL19 is predominantly present within dLNs.

H4 G94P proteins induce chromatin assembly, which increases free histones.

Increased microtubule acetylation repairs interference of axonal transport caused by LRRK2 Roc-COR domain mutations.

BLM gene encodes RecQ-class DNA helicase.

Increased microtubule acetylation worsens interference of axonal transport caused by LRRK2 Roc-COR domain mutations.


LDL cholesterol has a causal role in the development of cardiovascular disease.

The cytokine receptor which regulates chemotaxis and formation of lymph nodes is involved in production of myeloperoxidase in the left atrium.

Depletion of nitric oxide is responsible for vasospasm.

Cholesterol loading induces KLF4 expression in VSMCs, resulting in the expression of pro-inflammatory cytokines.

Alirocumab treatment reduces apo(a) fractional clearance rate.

Exhaustion of B cells contributes to poor Ab response in HIV-infected individuals.

Lamins have no effect on nuclear membrane structure maintenance.

Pyridostatin induces double-strand breaks accumulation.

Normal expression of RUNX1 causes tumorsupressing effects.

Mutant mice lacking SVCT2 have severely reduced ascorbic acid levels in both brain and adrenals.

Vitamin D is an important factor in the relationship between calcium and parathyroid hormone.

Increased LDL receptors plays a role in the reduction of plasma Lp(a).

A deficiency of folate increases blood levels of homocysteine.

Intake of folic acid (FA) and vitamin B6 (VB6) increases levels of homocysteine.

Intake of folic acid (FA) and vitamin B6 (VB6) reduces levels of homocysteine.

Higher plasma levels of I-carnitine, when associated with trimethylamine N-oxide, are negatively correlated with cardiovascular events in humans.

Higher plasma levels of I-carnitine, when associated with trimethylamine N-oxide, are positively correlated with cardiovascular events in humans.

A deficiency of vitamin B12 decreases blood levels of homocysteine.

IL-6 signaling plays a major role in atherosclerotic cardiovascular disease.


Female carriers of the Apolipoprotein E4 (APOE4) allele have increased risk for Alzheimer's disease.

7-day-old adult Caenorhabditis elegans exhibit approximately 5% of the learning capacity seen in 1-day old adults.

Bacteriophagaes MS2 and Qβ are members of the Leviviridae.

Upon viral challenge, influenza-specific memory CD4+ T cells greatly diminish the early production of inflammatory chemokines in the lung.

There is no association between HNF4A mutations and diabetes risks.

Early patent ductus ateriosus (PDA) screening increases in-hospital mortality.

There was an estimated 30 million cases of pneumonia in young children worldwide in 2010.

Gpr124 suppresses BBB breakdown in mouse models of ischemic stroke.

The myocardial cell lineage originally develops from cardiac progenitors of exclusively endodermal origin.

cSMAC formation represses weak ligand signalling.

In melanoma, anti-CTLA-4 treatment reinvigorates exhausted PD-1+Eomes+CD8 T cells.

G-CSF increases the expansion and infiltration of MDSCs into tumors.

CCL19 is predominantly present within dLNs.

The PPR MDA5 has twenty N-terminal CARD domains.

CDK6 shows improved binding to loss-of-function variants of p18 INK4C.

HOXB4 facilitates HSC expansion when co-cultured with HSCs.


There is no relation between Erythromycin use and hypertrophic pyloric stenosis.

CDK6 shows impaired binding to loss-of-function variants of p18 INK4C.

Many cytokines that are produced by cancer cells also contribute to carcinogenesis.

Upregulation of dynein in Drosophila neurons increases the number of microtubule plus-ends growing toward the cell body of each neuron.

Activator-inhibitor pairs are provided ventrally by Xrl-sizzled.

Alteration of origin firing causes changes in termination zones of Okazaki fragments.

Low nucleosome occupancy correlates with high methylation levels across species.

One in five surgical randomized controlled trials are discontinued early.

Ly6C hi monocytes have a higher inflammatory capacity than Ly6C lo monocytes.


LSD1-positive promoters are associated with RNA polymerase II

Men are more susceptible to death due to pneumonia when compared to women.

BLM gene encodes RecQ-class DNA helicase.

A T helper 2 cell (Th2) environment impedes disease development in patients with systemic lupus erythematosus (SLE).

Major antigen-induced signals from the T cell receptor and secondary signals from costimulatory receptors are required for T cell activation.

Patients with microcytosis and higher erythrocyte count are more vulnerable to severe malarial anaemia when infected with Plasmodium falciparum.

Female carriers of the Apolipoprotein E4 (APOE4) allele have shorter lifetime exposure to estrogen due to a decreased reproductive period.

IFIT1 speeds viral replication by allowing for the proliferation of mis-capped viral RNAs.

At least 85% of patients exposed to radiation have activated markers of myofibroblasts.

Cancer-associated fibroblasts (CAFs) have no known interaction with cancer cells in the formation and activation of CAFs.

RA activation of DIF2 and NB4 cells induces hallmarks of transcriptionally active promoters.

Localization of PIN1 in the roots of Arabidopsis requires VPS9a

JMJD6 catalyzes the hydroxylation of C-terminal lysine and supresses transcriptional activity.

Mutations in RIM1 decrease levels of IME1 RNA.

ALDH1 expression is associated with poorer prognosis for breast cancer primary tumors.

TNFAIP3 is a glioblastoma tumor suppressor.

Mutations in RIM1 raise levels of IME1 RNA.

TNFAIP3 is a glioblastoma tumor enhancer.


Lack of FGF21 in mice increases life expectancy.

Ribosome-inactivating protein-2 (RIP-2) interacts with the p75 NTR death domain

Increased lipolysis leads to higher P38 phosphorylation in adipose tissue.

Decrease of p62 in prostate tumor stroma results in defective autophagy.

PTEN is a regulator for the transcriptional activity of SRF

Gpr124 increases BBB breakdown in mouse models of ischemic stroke.

Deltex has no known interactions with eIF3f.

Alteration of origin firing causes changes in termination zones of Okazaki fragments.

Tumor development occurs in conjunction with suppression of pro-inflammatory cytokines.

Cytosolic proteins bind to iron-responsive elements on mRNAs coding for TFRC1.

Lack of FGF21 in mice leads to reduced lifespan.

Lack of FGF21 in mice leads to atherosclerotic plaque formation.

Lack of FGF21 in mice slows the rate of atherosclerotic plaque formation.

Mice lacking Sirt1 in Sf1-expressing neurons have increased susceptibility to diet-induced obesity and insulin resistance.

Mice lacking Sirt1 in Sf1-expressing neurons are immune to diet-induced obesity and insulin resistance.

Fibroblast growth factor 21 protects against atherosclerosis by modulating adiponectin and SREBP2 levels.

Autophagy deficiency in the liver increases vulnerability to insulin resistance.

In patients with congenital heart defects, β-blockers significantly improve clinical heart failure outcomes.

Ribosomal protein (RP) expression is controlled in part by stress-activated regulators.


Lack of FGF21 in mice leads to atherosclerotic plaque formation.

7-day-old adult Caenorhabditis elegans exhibit approximately 75% of the learning capacity seen in 1-day old adults.

Vitamin D is an important factor in the relationship between calcium and parathyroid hormone.

Eilat virus (EILV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in nonhuman primates.

Mutations in G-Beta protein GNB1 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.

A deficiency of vitamin B6 decreases blood levels of homocysteine.

Replacement of OCT4 and SOX2 genes with GATA3 has the ability to reprogram human cells.

PrimPol degrades short DNA replication intermediates on the leading strand during DNA replication.

Mutations in RIM1 decrease levels of IME1 RNA.

Many cytokines that are produced by cancer cells also contribute to carcinogenesis.

Upon viral challenge, influenza-specific memory CD4+ T cells greatly diminish the early production of inflammatory chemokines in the lung.

Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes fibrosis.

Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes epithelial damage.


Lack of FGF21 in mice leads to reduced lifespan.

Carriers of HNF4A mutations are at reduced risk for diabetes.

Exhaustion of B cells contributes to poor Ab response in HIV-infected individuals.

The US health care system can save up to $5 billion if 7% of patients waiting for kidney transplants participate in the optimized national kidney paired donation program.

HAND2 methylation is a key step in early endometrial carcinogenesis.

Cancer-associated fibroblasts (CAFs) interact with cancer cells to mediate formation and activation of CAFs.

The mean suicide rate in women is lower after miscarriage than live birth.

Omnivores produce less trimethylamine N-oxide from dietary I-carnitine than vegans.

Ribosomal protein (RP) expression is controlled in part by stress-activated regulators.

Sudden death can occur in patients with orthostatic hypertension without cardiac conduction abnormalities.

DMS3 protein enables Pol V transcription in vivo.


Lack of FGF21 in mice slows the rate of atherosclerotic plaque formation.

Gpr124 suppresses BBB breakdown in mouse models of ischemic stroke.

RANK-RANKL pathway signalling is linked to development of Aire-expressing medullary thymic epithelial cells.

Type 1 Diabetes is associated with subtle perturbations in T reg development.

There is no association between HNF4A mutations and diabetes risks.

The proliferative capacity of neural progenitors differs across species.

Increased lipolysis leads to higher P38 phosphorylation in adipose tissue.

Chinese individuals with TT homozygosity in the MTHFR gene are less vulnerable to strokes caused by low levels of folate intake.

Low expression of miR7a does not repress target genes or exert a biological function in testis.

The combination of physical examinations with C-reactive protein values do not improve the accuracy of radiographic verified pneumonia predictions.

Stroke patients with prior use of direct oral anticoagulants have a higher risk of in-hospital mortality than stroke patients with prior use of warfarin.


Lamins are associated with nuclear membrane structure maintenance.

Genomic sequences involved in alternative splicing responsible for Hutchinson-Gilford progeria syndrome (HGPS) are abundant in the ''progerinonly'' allele of Lmna knock-in models.

The risk of breast cancer among parous women decreases with placental weight of pregnancies.

IFI16 impedes STING phosphorylation and translocation, resulting in reduced activation of STING.

76-85% of people with severe mental disorder receive no treatment in low and middle income countries.

Neutrophils produce IL-1β in response to large particles.

De novo assembly of sequence data has fewer specific contigs than unassembled sequence data.

Prescribed exercise training improves quality of life.

Systemic immunosuppressive (IS) therapy increases the chance of cancer mortality in patients with inflammatory eye disease (IED)

Ca2+ cycling controls whole-body energy homeostasis in beige fat.

Lamins have no effect on nuclear membrane structure maintenance.

Lamins are found within the inner layer of the nuclear membrane of all cells.

Lamins are found within the inner layer of the mitochondrial membrane of all cells.

Myelin sheaths are lipid-rich cellular structures.

Myelin sheaths play a role in action potential propagation.

Intramembrane cleavage by signal peptide peptidase aids in the degradation of proteins with a complex membrane orientation.

The microtubule-dependent delivery and secretion of matrix metalloproteases (MMPs) is partially responsible for the disassembly of adhesion sites.

Flexible molecules experience less steric hindrance in the tumor microenviroment than rigid molecules.

Many transmembrane receptors transmit signals by long-range conformational changes in the association of alpha-helices across the plasma membrane.


Lamins are found within the inner layer of the mitochondrial membrane of all cells.

Activated Cdk5 regulates DNA damage-induced neuronal death.

32% of liver transplantation programs required patients to discontinue methadone treatment in 2001.

Reduced phosphorylation of PP2A suppresses HDAC4 dephosphorylation.

Toll-like receptor (TLR) signaling is involved in the pathogenesis of human MDS.

Active caspase-11 protein promotes pyroptosis.

Pre-mRNAs associated with spliceosomal components are more stable than unassociated splicing substrates.

There is a relation between Erythromycin use and hypertrophic pyloric stenosis.

Activated Cdk5 phosphorylates the ATM protein in response to DNA damage.

The PRDM1 gene is a key determinant of primordial germ cells.

Most termination events in Okazaki fragments are dictated by initiation patterns.

Post-transcriptional handling of mitochondrial transcripts occurs in mitochondrial RNA granules.

miRNAs regulate a unique suite of mRNAs to maintain homeostasis in cells.

Microglia are an innate immune cell type of the central nervous system.

MICAL redox enzymes regulate actin dynamics in many cell types.


Lamins are found within the inner layer of the nuclear membrane of all cells.

Mitochondria play a major role in apoptosis.

H4 G94P proteins suppress degradation of free histones via Rad53-dependent mechanisms.

Drosophila supracellular actomyosin structures are found at boundaries in wing imaginal discs.

The C-type lectin receptor (CLEC-2) rearranges the actin cytoskeleton in dendritic cells to promote efficient motility along stromal surfaces.

Transcription factor EB induces transcription of pro-inflammatory cytokines in macrophages infected with Staphylococcus aureus.

Acute ablation of Snail in the embryonic cortex affects the proliferation and number of embryonic cortical precursors.

Expression of oncolytic virus antigens as peptides permits additional protection against relapse.

Suboptimal nutrition is a leading cause of premature death

MafA phosphorylation decreases its ubiquitination.

The PDPN gene deactivates the C-type lectin receptor (CLEC-2).

Microglia are an innate immune cell type of the peripheral nervous system.

Cancer-associated fibroblasts (CAFs) are constituents of tumor microenvironments


Lamins have no effect on nuclear membrane structure maintenance.

Mutations in RIM1 raise levels of IME1 RNA.

A strong bias in the phage genome locations where the spacers were derived has been observed in many CRISPR subtypes that confer the immunity to phage.

In the UK, drowning affects boys and girls equally.

Microcin J25 encourages nucleoside triphosphate (NTP) binding.

MeCP2 influences the synaptic maturation of neurons.

At least 85% of patients exposed to radiation have activated markers of myofibroblasts.

Foxp3 enables the expression of transcriptional regulators implicated in memory T cell development.

The risk of female prisoners harming themselves is ten times that of male prisoners.

T cell receptor /CD3 microdomains are required to induce the immunologic synapse.

Dexamethasone increases risk of postoperative bleeding.

Lamins are associated with nuclear membrane structure maintenance.

Reduction of purity of cytoplasmic membranes isolated from overexpressors is indicated by stronger spots for OmpA in 2D BN-PAGE gels.


Less than 10% of patients exposed to radiation have activated markers of mesenchymal stem cells.

Incidence of heart failure increased by 10% in women since 1979.

Ribosome-inactivating protein-2 (RIP-2) interacts with the p75 NTR death domain

HOXB4 facilitates HSC expansion when co-cultured with HSCs.

A low percentage of hematopoietic progenitor cells are susceptible to HIV-1 infection ex vivo.

Tuberculosis incidence occurs at higher rates in more sparsely populated areas in the UK.

In domesticated populations of Saccharomyces cerevisiae, segmental aneuploidy occurs infrequently.

Combination nicotine replacement therapies with varenicline or bupropion are more effective after 12 weeks of reatment compared to varenicline monotherapy.

Mutations in G-Beta protein GNB1 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.

The first MBT repeat of the four malignant brain tumor (4MBT) domain of Drosophila's Sfmbt and of the orthologous mammalian L3MBTL2 is required for the interaction with the spacer region of Drosophila's Pleiohomeotic (Pho) or its human ortholog YY1.

50% of patients exposed to radiation have activated markers of mesenchymal stem cells.

At least 85% of patients exposed to radiation have activated markers of myofibroblasts.

1-1% of colorectal cancer patients are diagnosed with regional or distant metastases.

61% of colorectal cancer patients are diagnosed with regional or distant metastases.

Cancer-associated fibroblasts (CAFs) have no known interaction with cancer cells in the formation and activation of CAFs.

Many cytokines that are produced by cancer cells also contribute to carcinogenesis.

Cancer-associated fibroblasts (CAFs) interact with cancer cells to mediate formation and activation of CAFs.

Induced hepatic stem cells possess the potential to differentiate into cholangiocytic cells.


Lice attenuated SIV vaccines induce a stronger antigen-specific T cell response in lymph node cells.

Approximately 250,000 people are infected with human T-cell lymphotropic virus type 1 in the United Kingdom.

Eilat virus (EILV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in nonhuman primates.

Vaccinating the gastrointestinal tract induces protection of rectal and vaginal mucosa.

MafA phosphorylation decreases its ubiquitination.

Adult tissue-resident macrophages are seeded before birth.

The origin of the CRF01_1b2k protein occurred between 1923 and 1956.

Sequence conservation in gene regulatory regions between species is a poor predictor of conserved functionality.

Induction of urokinase receptor signaling in podocytes causes foot process effacement and proteinuria.

Integrated care is ineffective at tackling multiple comorbidities.

Major antigen-induced signals from the T cell receptor and secondary signals from costimulatory receptors are required for T cell activation.

CD28 signals regulate trafficking of murine auto-reactive T cells into target tissues.

In pediatric tissue, most T cells are naive T cell emigrants from the thymus.

A T helper 2 cell (Th2) environment impedes disease development in patients with systemic lupus erythematosus (SLE).

IL-10 production by monocytes inhibits CD4 + T cell response.

EG7 tumors can be killed by systemic oxaliplatin primed CD8+ T cells from the tumor-draining lymph node cells.

Peroxynitrite is required for induction of T cell tolerance.

Type 1 Diabetes is associated with subtle perturbations in T reg development.


Lipopolysaccharides have an inflammation independent effect on kidney barrier function.

Deletion of ATM and Rad3 related protein leads to acute tissue loss.

Genes involved in pre-mRNA splicing have a significant impact on genome stability.

A 100g dose of chloroquine chemoprophylactic regimen results in retinal toxicity after 5-6 years of weekly intake.

Deltex interacts with eIF3. There is no known interaction between Deltex and elF3

Upon viral challenge, influenza-specific memory CD4+ T cells greatly enhance the early production of inflammatory chemokines in the lung.

Taking anti-depresents is associated with a decrease in the Aβ level in the brain of experimental animals.

ATM and Rad3 related protein are critical for sensing DNA damage.

Cancer-associated fibroblasts (CAFs) have no known interaction with cancer cells in the formation and activation of CAFs.

IL-10 production by monocytes inhibits CD4 + T cell response.

N348I mutations reduce resistance to nevirapine.

The effect of Lipopolysaccharides on kidney barrier function is dependent on inflammation levels.

Angiotensin converting enzyme inhibitors are associated with decreased risk for functional renal insufficiency.

AMP-activated protein kinase (AMPK) activation reduces inflammation-related fibrosis in the lungs.

NAC destabilizes NO to increase the effect of contrast agents on renal functions.

Reduced levels of lipolysis leads to higher P38 phosphorylation in adipose tissue.

Increased lipolysis leads to higher P38 phosphorylation in adipose tissue.

Inhibiting glucose-6-phospate dehydrogenase improves lipogenesis by deactivating LKB1-AMPK signaling.

Myelin sheaths are lipid-rich cellular structures.

Basophils promote disease development in patients with systemic lupus erythematosus (SLE).


Lmna knock-in models are appropriate for testing therapeutic approaches against Hutchinson-Gilford progeria syndrome (HGPS).

Converting apoE4 to apoE3 by gene editing prevents the pathology associated with apoE4 in human iPSCderived neurons.

Pyridostatin encourages proliferation of homologous recombination - defective cells.

Sympathetic nerve activity is reduced throughout normal pregnancy.

Higher plasma levels of I-carnitine, when associated with trimethylamine N-oxide, are negatively correlated with cardiovascular events in humans.

Osteocytes have an essential role in G-CSF induced HSPC mobilization.

The NF-κB essential modulator gene induces intestinal inflammation by promoting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death.

Origin gross domestic product(GDP) is negatively related to dengue virus (DENV-1) diffusion in air traffic shipments.

PGE 2 suppresss intestinal tumor growth by altering the expression of tumor suppressing and DNA repair genes.

Genomic sequences involved in alternative splicing responsible for Hutchinson-Gilford progeria syndrome (HGPS) are abundant in the ''progerinonly'' allele of Lmna knock-in models.

Understanding epigenetic regulation of replication is essential for the reational design of episomally replicating vectors.

Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission.

Increased mobility of retrotransposons does not lead to mutation and higher tumorigenesis rates.

Increased mobility of retrotransposons is assosciated with mutation and higher tumorigenesis rates.

Genomic aberrations of metastases provide information for targeted therapy.

Monoclonal antibody targeting of N-cadherin encourages metastasis.

N348I mutations reduce resistance to nevirapine.

HNF4A mutations are associated with macrosomia in infancy.


Localization of PIN1 in the roots of Arabidopsis requires VPS9a

50% of patients exposed to radiation have activated markers of mesenchymal stem cells.

The tissue surrounding the granuloma in an immune cell induces an anti-inflammatory immune response.

HOXB4 facilitates HSC expansion when co-cultured with HSCs.

Pro-inflammatory cytokines are up repressed during tumor development.

In domesticated populations of Saccharomyces cerevisiae, segmental aneuploidy occurs infrequently.

Combination nicotine replacement therapies with varenicline or bupropion are more effective after 12 weeks of reatment compared to varenicline monotherapy.

Reduced levels of lipolysis leads to higher P38 phosphorylation in adipose tissue.

Enhanced early production of inflammatory chemokines damages viral control in the lung.

Lice attenuated SIV vaccines induce a stronger antigen-specific T cell response in lymph node cells.

LSD1-positive promoters are associated with RNA polymerase II

Emodin forms hydrogen bonds with residues involved in PGAM1 substrate binding.

taa1 tar1 tar2 triple mutants in Arabidopsis do not make root meristem during embryogenesis.

Low expression of miR7a does not repress target genes or exert a biological function in ovaries.

Removal of H3K9me3 by ectopic expression of other H3K9 demethylases improves reprogramming efficiency in SCNT experiments.

Low expression of miR7a does not repress target genes or exert a biological function in testis.

Removal of H3K9me3 by ectopic expression of other H3K9 demethylases decreases reprogramming efficiency in SCNT experiments.

IFIT1 speeds viral replication by allowing for the proliferation of mis-capped viral RNAs.

The artifactual C-terminal helix swapping in the StART domain is observed in the Ups1-Mdm35 heterodimer of the StARkin superfamily.


Long - range chromatin interactions regulate transcription.

Cholesterol loading induces KLF4 expression in VSMCs, resulting in the expression of pro-inflammatory cytokines.

Foxk2 regulates autophagy genes in muscle cells and fibroblast cells.

Destination container port throughput(CPT) is positively related to dengue virus (DENV-1) diffusion in air traffic shipments.

The tip of the inner tube of the toxic type VI secretion system (T6SS) antibacterial effector in Escherichia coli (E. coli) is decorated with VgrG and PAAR proteins.

Lack of FGF21 in mice leads to reduced lifespan.

Ca2+ cycling is a UCP1-independent thermogenic mechanism.

Women are more susceptible to death due to pneumonia when compared to men.

Origin gross domestic product(GDP) is negatively related to dengue virus (DENV-1) diffusion in air traffic shipments.

Klf2 is important for proper myeloid cell function.

HbA1c consistently overestimates glycemic control in black individuals with Sickle cell trait (SCT).

Distant CREs are important for transcriptional regulation.

Cellular differentiation of embryonic stem cells is accompanied by changes in replication timing, transcription and nuclear localization.

Sequence conservation in gene regulatory regions between species is a high-accuracy predictor of conserved functionality.

Trans-acting factors, such as lncRNAs, influence mRNA translation.

Genes involved in pre-mRNA splicing have a significant impact on genome stability.

Cis-acting lncRNAs control the expression of genes that are positioned in the vicinity of their transcription sites.

miRNAs regulate a unique suite of mRNAs to maintain homeostasis in cells.

Mitochondria play a major role in energy production.

Sequence conservation in gene regulatory regions between species is a poor predictor of conserved functionality.


Long chain polyunsaturated fatty acids supplementation has no significant effects on wheezing or asthma at 3 and 6 years.

Clathrin stabilizes the spindle fiber apparatus during mitosis.

Lamins are associated with nuclear membrane structure maintenance.

FACT and other histone chaperone(s) compensate for Histone 2A (H2A)-histone 2B (H2B) dimer eviction during the histone exchange process.

The risk of cancer rises with level of alcohol consumption.

Patients in stable partnerships have a slower progression from HIV to AIDS.

Bariatric surgery increases rates of colorectal cancer.

The appearance of brown-like or beige cells primarily occurs in visceral fat, not subcutaneous fat.

Increased flux of microbial products suppresses immune responses.

Side effects associated with antidepressants lower risk of myocardial infarction.

Integrating classroom-based collaborative learning with Web-based collaborative learning offers the best class performance.

Long chain polyunsaturated fatty acids supplementation reduces wheezing and asthma.

Long chain polyunsaturated fatty acids supplementation is associated with lower rates of atopic eczema at 1 year.

Omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegans.

Intake of folic acid (FA) and vitamin B6 (VB6) reduces levels of homocysteine.

Omnivores produce less trimethylamine N-oxide from dietary I-carnitine than vegans.

LDL cholesterol has a causal role in the development of cardiovascular disease.

There is no increased risk of hypospadias with clomiphene.

Intake of folic acid (FA) and vitamin B6 (VB6) increases levels of homocysteine.

Vitamin D deficiency effects birth weight.


Long chain polyunsaturated fatty acids supplementation is associated with lower rates of atopic eczema at 1 year.

APOE4 expression in iPSC-derived neurons results in decreased tau phosphorylation.

ScPif1p has higher binding ability to G-rich ssDNA than to non-G-rich ssDNA.

YAP/TAZ is required in intestinal regeneration in mouse models of ulcerative colitis.

Citrullinated proteins externalized in neutrophil extracellular traps act indirectly to disrupt the inflammatory cycle.

Pharmacist attendance at ward rounds reduces adverse events in wards.

Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes fibrosis.

Taking 400mg of α-tocopheryl acetate does not prevent prostate cancer.

Post-transcriptional handling of mitochondrial transcripts occurs in mitochondrial RNA granules.

The deamination of cytidine to uridine on the minus strand of viral DNA can inactivate the viral genome by inducing G-to-A mutations.

Thiopurine active metabolites can be catabolized through dephosphorylation of thioguanine nucleotides.

Pioglitazone use is significantly associated with an increased risk of pancreatic cancer.


Long chain polyunsaturated fatty acids supplementation reduces wheezing and asthma.

There is no relation between Erythromycin use and hypertrophic pyloric stenosis.

Origin gross domestic product(GDP) is positively related to dengue virus (DENV-1) diffusion in air traffic shipments.

KRT17 modulates the expression of the transcriptional regulator AIRE in diseased epithelia.

Cancer-associated fibroblasts (CAFs) are constituents of tumor microenvironments

Satellite cell dysfunction is a key factor in sarcopenia development.

Drosophila supracellular actomyosin structures are found at boundaries in wing imaginal discs.

Pioneer factor OCT3/4 interacts with major chromatin remodeling factors.

Lmna knock-in models are appropriate for testing therapeutic approaches against Hutchinson-Gilford progeria syndrome (HGPS).

Human embryonic stem cells have the capacity to give rise to differentiated progeny representative of all three embryonic germ layers.

Polymeal nutrition increases cardiovascular mortality.

Omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegetarians.


Low expression of miR7a does not repress target genes or exert a biological function in ovaries.

Active H. pylori urease has a polymeric structure consisting of five distinct subunits.

Ca2+ cycling is a UCP1-independent thermogenic mechanism.

There is no increased risk of hypospadias with clomiphene.

siRNA knockdown of A20 slows tumor progression in an in vivo murine xenograft model.

TRAP+ osteoclasts regulate mature osteoblast maintenance.

Inhibiting focal adhesion formation enables cells to convert mechanical strain into eventual scarring.

M. stadtmanae does not induce ASC speck formation in BlaER1 monocytes.

Helminths interfere with immune system control of coinfections by microbial pathogens 16.

Bone marrow cells don't contribute to adult macrophage compartments.

Pioglitazone use is significantly associated with an increased risk of prostate cancer.

Low expression of miR7a does not repress target genes or exert a biological function in testis.

miRNAs regulate a unique suite of mRNAs to maintain homeostasis in cells.

miRNAs enforce homeostasis by suppressing low-level ''leaky'' transcription.

Major vault protein (MVP) leads to more aggressive tumors by regulating the sorting of tumor suppressive miR-193a into extracellular vesicles (EVs).

TNFAIP3 is a glioblastoma tumor suppressor.

TNFAIP3 is a glioblastoma tumor enhancer.

TNFAIP3 is a tumor enhancer in glioblastoma.

ALDH1 expression is associated with poorer prognosis for breast cancer primary tumors.

MafA phosphorylation enhances its ubiquitination.


Low expression of miR7a does not repress target genes or exert a biological function in testis.

De novo assembly of sequence data has shorter contigs than unassembled sequence data.

Antidepressants reduce the severity of migraines.

Adult tissue-resident macrophages possess a self-renewing capacity.

Guanine nucleotide dissociation inhibitor (Rho-GDI) interacts with the p75 NTR death domain

Fibroblast Growth Factor is a ligand which signals through receptor tyrosine kinases.

Ca2+ cycling is a UCP1-dependent thermogenic mechanism.

Female carriers of the Apolipoprotein E4 (APOE4) allele have increased risk for Alzheimer's disease.

qSOFA scores are associated with length of stay in emergency department patients.

Side effects associated with antidepressants do not represent a mortality risk to postmenopausal women.

Microglia are an innate immune cell type of the central nervous system.

R2D2 stops miRNA production by increasing the selectivity of Dcr2 for long dsRNA.


Low nucleosome occupancy correlates with high methylation levels across species.

Post-transcriptional handling of mitochondrial transcripts occurs in mitochondrial RNA granules.

In S. cerevisiae, the absence of RNA surveillance pathways causes sensitivity to high iron conditions.

Thiopurine active metabolites can be catabolized through dephosphorylation of thioguanine nucleotides.

V-9302 inhibits antitumor responses by decreasing cell death and oxidative stress.

ART has no effect on the infectiveness of HIV-positive people.

Nonhypertensive people who are 55 years old have a 90% chance of developing hypertension during their lifetime.

Low expression of miR7a does not repress target genes or exert a biological function in ovaries.

Clathrin stabilizes the spindle fiber apparatus during mitosis.

Walking in traffic areas in London improves lung function in elderly adults.

IgA plasma cells that are specific for transglutaminase 2 are scarce in the duodenal mucosa of celiac disease patients when the disease is active.

Sequence conservation in gene regulatory regions between species is a poor predictor of conserved functionality.

Sequence conservation in gene regulatory regions between species is a high-accuracy predictor of conserved functionality.

The generation of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells.

The removal of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells.

Pseudoknots are not evolutionarily conserved in most eukaryotes.

Rapid phosphotransfer rates are correlated with histidine kinase regulator specificity.

Long - range chromatin interactions regulate transcription.

A deficiency of vitamin B12 decreases blood levels of homocysteine.


Ly49Q directs the organization of neutrophil polarization by regulating membrane raft functions.

ERAP1 SNPs are epistatic to HLA alleles for ankylosing spondylitis.

PCSK9 inhibitors decrease plasma Lp(a) levels.

Chlamydia trachomatis is most prevalent in the UK among sexually-experienced individuals aged 16 to 24.

Chenodeoxycholic acid treatment increases brown adipose tissue activity.

A single nucleotide variant the gene DGKK is strongly associated with increased risk of hypospadias.

Pyridostatin induces double-strand breaks accumulation.

Headaches are correlated with cognitive impairment.

p16INK4A degradation is  linked to an abnormal wound response caused by the microinvasive step of advanced Oral Potentially Malignant Lesions (OPMLs).

10% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months.

Mice defective for deoxyribonucleic acid (DNA) polymerase m (polm) fail to reveal increased sensitivity to ionizing radiation (IR).

Active Ly49Q induces neutrophil polarization.

Active Ly49Q prevents neutrophil polarization.

Many transmembrane receptors transmit signals by long-range conformational changes in the association of alpha-helices across the plasma membrane.

Kir7.1 modulates channel activity by the G protein-coupled melanocortin-4 receptor (MC4R) in the paraventricular nucleus of the hypothalamus.

Intramembrane cleavage by signal peptide peptidase aids in the degradation of proteins with a complex membrane orientation.

ITAM phosphorylation allows for the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).

Active caspase-11 participate in regulating phagosome-lysosome fusion.

miRNAs regulate a unique suite of mRNAs to maintain homeostasis in cells.

JMJD6 slows the hydroxylation of C-terminal lysine


Ly6C hi monocytes have a higher inflammatory capacity than Ly6C lo monocytes.

Healthy volunteers exhibit rapid and transient increase of cellular ATP after being bolus-injected with fructose.

Deletion of ATM and Rad3 related protein leads to acute tissue loss.

Including pharmacists in rounding teams does not alter the incidence of adverse drug events (ADEs).

Activation of the Rac1 homolog CED-10 kills viable cells in SRGP-1 mutant Caenorhabditis elegans.

H4 G94P proteins inhibit chromatin assembly, which decreases free histones.

The removal of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells.

Citrullinated proteins externalized in neutrophil extracellular traps act indirectly to disrupt the inflammatory cycle.

Monoclonal antibody targeting of N-cadherin encourages metastasis.

Myelin sheaths play a role in action potential propagation.

Human embryonic stem cells have the capacity to give rise to differentiated progeny representative of all three embryonic germ layers.

Cancer-associated fibroblasts (CAFs) have no known interaction with cancer cells in the formation and activation of CAFs.

The M2-phenotype in brown adipose tissue macrophages increases brown adipose tissue thermogenic activity.

Bone marrow cells don't contribute to adult macrophage compartments.

Cancer-associated fibroblasts (CAFs) interact with cancer cells to mediate formation and activation of CAFs.

M. stadtmanae does not induce ASC speck formation in BlaER1 monocytes.

Klf4 is important for proper myeloid cell differentiation.

Induced hepatic stem cells possess the potential to differentiate into cholangiocytic cells.

M. stadtmanae induces ASC speck formation in BlaER1 monocytes.

The cytokine receptor which regulates chemotaxis and formation of lymph nodes is involved in production of myeloperoxidase in the left atrium.


Lysine histone demethylase inhibitor JIB 04 is inactive against KDM5A.

Incidence of 10/66 dementia is lower than the incidence of DSM-IV dementia.

Energy balance requires hypothalamic glutamate neurotransmission.

Pharmacist attendance at ward rounds increases adverse events in wards.

Thiopurine active metabolites can be catabolized through dephosphorylation of thioguanine nucleotides.

Increased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm.

The innate immune response struggles to remove small numbers of parasites.

Students who perform poorly in the early years of medical school are at increased risk for professional misconduct later in their careers.

Medications to treat obesity are highly effective.

Up-regulation of the p53 pathway and related molecular events speeds cancer progression.

Antiretroviral therapy increases rates of tuberculosis across a broad range of CD4 strata.

Removal of H3K9me3 by ectopic expression of other H3K9 demethylases improves reprogramming efficiency in SCNT experiments.

Removal of H3K9me3 by ectopic expression of other H3K9 demethylases decreases reprogramming efficiency in SCNT experiments.

Guanine nucleotide dissociation inhibitor (Rho-GDI) interacts with the p75 NTR death domain

Replacement of histone H2A with H2A.Z accelerates gene activation in yeasts by destabilizing +1 nucleosomes.

C2 works synergistically with A-769662 to activate dephosphorylated AMPK.

Smc5/6 engagment halts the activation of SUMO E3 ligase Mms21 by ATP-dependent remolding.

B3-Galectin decreases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR.

B3-Galectin increases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR.


M. stadtmanae does not induce ASC speck formation in BlaER1 monocytes.

Asymptomatic visual impairment screening in elderly populations leads to improved vision.

β-sheet opening occurs during pleurotolysin pore formation.

Many transmembrane receptors transmit signals by long-range conformational changes in the association of alpha-helices across the plasma membrane.

The proliferative capacity of neural progenitors differs across species.

Bariatric surgery leads to positive outcomes in mental health.

Ultrasound guidance significantly reduces the number of needle insertion attempts necessary for a given procedure.

Patients with microcytosis and higher erythrocyte count are more vulnerable to severe malarial anaemia when infected with Plasmodium falciparum.

Mutations in RIM1 raise levels of IME1 RNA.

The morphology change from large white adipocytes to small brown adipocytes is a sign of increased energy expenditure potential in white adipose tissue.

Varying expression levels of EBI2 affect the positioning and migration of B cells.

Ly6C hi monocytes have a higher inflammatory capacity than Ly6C lo monocytes.

The deregulated and prolonged activation of monocytes has deleterious effects in chronic infectious conditions.

GATA3 regulates cell cycle progression in bone marrow hematopoietic stem cells.

PD-1 triggering on monocytes enhances IL-10 production by monocytes.

GATA3 regulates self-renewal capacity in bone marrow hematopoietic stem cells.

Klf4 is not required for proper myeloid cell differentiation.

Activation of the Rac1 homolog CED-10 kills viable cells in SRGP-1 mutant Caenorhabditis elegans.


M. stadtmanae induces ASC speck formation in BlaER1 monocytes.

Patients with common epithelial cancers  are more likely to have an emergency event as their first hospital admission if they live in resource-deprived areas.

Noninvasive positive pressure ventilation is not predictive of acute respiratory failure after solid organ transplantation.

Chinese individuals with TT homozygosity in the MTHFR gene are more vulnerable to strokes caused by low levels of folate intake.

Diminished ovarian reserve is a reliable indicator of infertility in a non-infertile population.

Gastric infection with Helicobacter pylori increases risk of gastric cancer in humans.

Pharmacist attendance at ward rounds reduces adverse events in wards.

In melanoma, anti-CTLA-4 treatment reinvigorates exhausted PD-1+Eomes+CD8 T cells.

Stiff substrates encourage mesodermal differentiation by degrading beta-catenin in an integrin-dependent manner.

Polymeal nutrition increases cardiovascular mortality.

H.pylori-mediated gastric cancer occurs due to the accumulation of mutations in host epithelial cells.

M. stadtmanae does not induce ASC speck formation in BlaER1 monocytes.

Cancer cells can stimulate the accumulation of intra-tumoural myeloid-derived suppressor cells by promoting granulocyte colony stimulating factor production.

Glioblastoma multiforme (GBM) is characterized by extensive invasion, rapid growth, necrosis, and angiogenesis.


MEK inhibitors are effective treatments in RAS-driven mouse models of cancer.

Klf4 is not required for proper myeloid cell differentiation.

Differentiation of progenitor cells to myeloid cells is skewed upon activation of insulin signaling.

Recognition of start codons depends on the translation initiation factor IF3.

Sudden death can occur in patients with complex ventricular arrhythmias.

The C-type lectin receptor (CLEC-2) rearranges the actin cytoskeleton in dendritic cells to promote efficient motility along stromal surfaces.

An M2-like phenotype in brown adipose tissue macrophages is quickly induced by cold exposure.

Omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegans.

Omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegetarians.

taa1 tar1 tar2 triple mutants in Arabidopsis do not make root meristem during embryogenesis.

NR5A2 is important in reverse cholesterol transport in humans.

TNFAIP3 is a glioblastoma tumor suppressor.

Cancer-associated fibroblasts (CAFs) interact with cancer cells to mediate formation and activation of CAFs.

Cancers that initially benefit from epidermal growth factor receptor targeted therapies later become refractory through several mechanisms.

TNFAIP3 is a glioblastoma tumor enhancer.

TNFAIP3 is a tumor enhancer in glioblastoma.

Cancer-associated fibroblasts (CAFs) have no known interaction with cancer cells in the formation and activation of CAFs.

DUSP4 downregulation deactivates the Ras-ERK pathway

Upon developing tyrosine-kinase inhibitor resistance, new mutations in epidermal growth factor receptors emerge and cause treatment failure.

Cancer-associated fibroblasts (CAFs) are constituents of tumor microenvironments


MFGE8 regulates fat absorption by binding to av-Beta3 and av-Beta5 integrins.

CHOP is a general endoplasmic reticulum stress marker.

Side effects associated with antidepressants do not represent a mortality risk to postmenopausal women.

MEK inhibitors are effective treatments in RAS-driven mouse models of cancer.

Increased microtubule acetylation exacerbates LRRK2 Roc-COR domain mutation induced locomotor deficits.

DRD1 proteins enable Pol V transcription in vivo.

Deregulation of HAND2 is a crucial step in endometrial carcinogenesis in mice.

N348I mutations cause resistance to nevirapine.

The mean suicide rate in women is lower after miscarriage than live birth.

Participants who quit smoking reduce lung cancer risk by approximately 50%.

MUC1-C activates the NF-κB p65 signaling pathway by interacting with IκB kinase ß.

APOE4 expression in iPSC-derived neurons results in decreased tau phosphorylation.

ATF4 is a general endoplasmic reticulum stress marker.

Intake of folic acid (FA) and vitamin B6 (VB6) increases levels of homocysteine.

Ca2+ cycling controls whole-body energy homeostasis in beige fat.

Inhibiting glucose-6-phospate dehydrogenase improves lipogenesis by deactivating LKB1-AMPK signaling.

Increased lipolysis leads to higher P38 phosphorylation in adipose tissue.

Klf4 is important for proper myeloid cell differentiation.

Reduced levels of lipolysis leads to higher P38 phosphorylation in adipose tissue.


MICAL redox enzymes regulate actin dynamics in many cell types.

Reduction of purity of cytoplasmic membranes isolated from overexpressors is indicated by stronger spots for OmpF in 2D BN-PAGE gels.

IFI16 impedes STING phosphorylation and translocation, resulting in reduced activation of STING.

Nonsteroidal antinflammatory drugs show potential anticancer indications.

Mitochondria play a major role in energy production.

Lysine histone demethylase inhibitor JIB 04 is inactive against KDM5A.

Normal granulomas form in the absence of TNF in Zebrafish.

In transgenic mice harboring green florescent protein under the control of the Sox2 promoter, more than 50 percent of the cells with green florescent colocalize with cell proliferation markers.

Cholesterol loading induces KLF4 expression in VSMCs, resulting in the expression of pro-inflammatory cytokines.

Persistor cells are one reason for incomplete responses to Tyrosine kinase inhibitor (TKI) therapy in cancer patients.

MICAL redox enzymes regulate actin dynamics.

The C-type lectin receptor (CLEC-2) rearranges the actin cytoskeleton in dendritic cells to promote efficient motility along stromal surfaces.

Oxidative phosphorylation is one of the primary glycometabolic pathways in cells.

Lamins are found within the inner layer of the mitochondrial membrane of all cells.

Mitochondria play a trivial role in calcium homeostasis.

Guanine nucleotide exchange factors (GEFs) mediate RhoA activation in response to tensional forces on fibronectin-binding integrins.

Myelin sheaths play a role in action potential propagation.

The Snf1 complex regulates carbon and energy metabolism in baker's yeast (Saccharomyces cerevisiae).


MICAL redox enzymes regulate actin dynamics.

ART has no effect on the infectiveness of HIV-positive people.

The minor G allele of FOXO3 downregulates pro-inflammatory cytokines.

The combination of physical examinations with C-reactive protein values do not improve the accuracy of radiographic verified pneumonia predictions.

Ethanol stress increases the expression of PSP in bacteria.

Active caspase-11 protein promotes pyroptosis.

Removal of H3K9me3 by ectopic expression of other H3K9 demethylases decreases reprogramming efficiency in SCNT experiments.

Oxidative phosphorylation is one of the primary glycometabolic pathways in cells.

Pyridostatin induces double-strand breaks accumulation.

Addition of BMP4, activin A, CHIR99021, and SU504 to reprogramming fibroblasts generates, expands and maintains cardiovascular progenitor cells (CPCs)

Varenicline monotherapy is more effective after 26 weeks of treatment compared to combination nicotine replacement therapies with varenicline or bupropion.

Deltex interacts with eIF3. There is no known interaction between Deltex and elF3


MT binding domain drives amyloid structure formation.

One in two surgical randomized controlled trials are discontinued early.

Input from  mental and physical health care professionals is not effective at decreasing homelessness.

Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission.

Increased flux of microbial products provokes immune responses.

CHOP is a general endoplasmic reticulum stress marker.

Diabetes remission occurs more in people treated with conventional therapy than in people treated with laparoscopic adjustable gastric banding surgery.

The TRaF1/C5 rs10818488 allele polymorphism regulates the neighboring C5 gene.

Crossover hot spots are found within gene promoters in Saccharomyces cerevisiae.

Early patent ductus ateriosus (PDA) screening decreases in-hospital mortality.

EG7 tumors can be killed by systemic oxaliplatin primed CD8+ T cells from the tumor-draining lymph node cells.

H4 G94P proteins inhibit chromatin assembly, which decreases free histones.

H4 G94P proteins induce chromatin assembly, which increases free histones.

H4 G94P proteins induce degradation of free histones via Rad53-dependent mechanisms.

Cyclin A2 destruction is necessary to switch from unstable to stable kt-mt attachments in mitosis.

Deletion of ATM and Rad3 related protein leads to acute tissue loss.

TRAP+ osteoclasts regulate mature osteoblast maintenance.

H4 G94P proteins suppress degradation of free histones via Rad53-dependent mechanisms.

APOE4 expression in iPSC-derived neurons results in decreased tau phosphorylation.

The microtubule-dependent delivery and secretion of matrix metalloproteases (MMPs) is partially responsible for the disassembly of adhesion sites.


MUC1-C activates the NF-κB p65 signaling pathway by interacting with IκB kinase ß.

RANK-RANKL pathway signalling is linked to development of Aire-expressing medullary thymic epithelial cells.

Chenodeoxycholic acid treatment increases brown adipose tissue activity.

Allogeneic mechanical circulatory support is not as effective as autologous mechanical circulatory support for treating acute myocardial infarction.

Intramembrane cleavage by signal peptide peptidase aids in the degradation of proteins with a complex membrane orientation.

A T helper 2 cell (Th2) environment impedes disease development in patients with systemic lupus erythematosus (SLE).

Pre-mRNAs associated with spliceosomal components are more stable than unassociated splicing substrates.

Individuals with low serum vitamin D concentrations have decreased risk of multiple sclerosis.

Homozygous deletion of murine Sbds gene from osterix-expressing mesenchymal stem and progenitor cells (MPCs) induces oxidative stress.

Walking in traffic areas in London did not improve lung function in elderly adults.

TNFAIP3 is a tumor enhancer in glioblastoma.

The NF-κB essential modulator gene induces intestinal inflammation by promoting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death.

The NF-κB essential modulator gene prevents intestinal inflammation by inhibiting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death.

Mutations in G-Beta protein GNB1 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway.

p16INK4A degradation is encoded by CDKN2A.

MFGE8 regulates fat absorption by binding to av-Beta3 and av-Beta5 integrins.

TNFAIP3 is a glioblastoma tumor suppressor.

Foxp3 represses the expression of transcriptional regulators implicated in memory T cell development.

The Snf1 complex regulates carbon and energy metabolism in baker's yeast (Saccharomyces cerevisiae).

Foxp3 enables the expression of transcriptional regulators implicated in memory T cell development.


MafA phosphorylation decreases its ubiquitination.

Helicobacter pylori-induced aberrant NF-kB-dependent expression of activation-induced cytidine deaminase contributes to the mutagenesis of host DNA.

Osteocytes have an essential role in G-CSF induced HSPC mobilization.

MUC1-C activates the NF-κB p65 signaling pathway by interacting with IκB kinase ß.

Mice defective for deoxyribonucleic acid (DNA) polymerase m (polm) reveal increased sensitivity to ionizing radiation (IR).

Pioglitazone use is significantly associated with an increased risk of prostate cancer.

Tuberculosis-induced granulomas express different immune system protein signatures than the surrounding tissue.

Transplanted human glial progenitor cells can mature in their host animal.

MafA phosphorylation enhances its ubiquitination.

MafA ubiquitination increases the recruitment of coavtivator P/CAF by MafA.

MafA ubiquitination decreases the recruitment of coavtivator P/CAF by MafA.

TNFAIP3 is a glioblastoma tumor enhancer.

TNFAIP3 is a tumor enhancer in glioblastoma.

Low expression of miR7a does not repress target genes or exert a biological function in ovaries.

Upregulation of PD1 causes the downmodulation of Satb1.

Mutations in RIM1 decrease levels of IME1 RNA.


MafA phosphorylation enhances its ubiquitination.

N348I mutations cause resistance to nevirapine.

Immune complex triggered cell death leads to sequestration of oxidized mitochondrial DNA.

Gpr124 increases BBB breakdown in mouse models of ischemic stroke.

The Snf1 complex regulates carbon and energy metabolism in baker's yeast (Saccharomyces cerevisiae).

Scapular stabilizer exercises are more effective than general exercise therapy in reducing pain and improving function of the shoulder.

F4/80+ macrophages regulate mature osteoblast maintenance.

Cnn1 recruitment varies with cell cycle timing.

Repressing IL-18 has negative effects on atherosclerotic lesion composition and progression.

Commelina yellow mottle virus (ComYMV) has three typical badnavirus ORFs, capable of encoding proteins 23, 15, and 216 kD.

An M2-like phenotype in brown adipose tissue macrophages is quickly induced by cold exposure.

Emodin forms hydrogen bonds with residues involved in PGAM1 substrate binding.


MafA ubiquitination decreases the recruitment of coavtivator P/CAF by MafA.

Side effects associated with antidepressants increases risk of stroke.

Activator-inhibitor pairs are provided ventrally by Xrl-sizzled.

Increased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm.

Primary cervical cytology screening with HPV detection has higher longitudinal sensitivity to detect severe cervical intraepithelial neoplasia than conventional cytology.

Consumption of whole fruits increases the risk of type 2 diabetes.

Mutations in RIM1 decrease levels of IME1 RNA.

Sn is present on mature DCs during inflammation in vivo.

Fibroblast growth factor 21 protects against atherosclerosis by modulating adiponectin and SREBP2 levels.

The innate immune response struggles to remove small numbers of parasites.

The microtubule-dependent delivery and secretion of matrix metalloproteases (MMPs) is partially responsible for the disassembly of adhesion sites.

Alirocumab treatment reduces apo(a) fractional clearance rate.

Formation of N-terminal pyroglutamate by glutamine cyclase (GC) competes with NTAQ1 for Nt-Gln substrates.

ScPif1p has reduced binding ability to G-rich ssDNA compared to non-G-rich ssDNA.

ScPif1p has higher binding ability to G-rich ssDNA than to non-G-rich ssDNA.


MafA ubiquitination increases the recruitment of coavtivator P/CAF by MafA.

Mouse models can be generated using "artificial spermatids."

The cytokine receptor which regulates chemotaxis and formation of lymph nodes is involved in production of myeloperoxidase in the left atrium.

Reduction of purity of cytoplasmic membranes isolated from overexpressors is indicated by stronger spots for OmpA in 2D BN-PAGE gels.

LSD1-positive promoters are associated with RNA polymerase II

Deltex has no known interactions with eIF3f.

Pure neural progenitor cell (NPC) populations can only be obtained from cell cultures that undergo passaging, filtration, or other isolation and cell sorting methods.

Increase of p62 in prostate tumor stroma results in defective autophagy.

Ethanol stress increases the expression of IBP in bacteria.

MEK inhibitors are effective treatments in RAS-driven mouse models of cancer.


Major antigen-induced signals from the T cell receptor and secondary signals from costimulatory receptors are required for T cell activation.

Glioblastoma multiforme (GBM) is characterized by extensive invasion, rapid growth, necrosis, and angiogenesis.

Natriuretic peptides increase susceptibility to diabetes.

Moderate consumption of candy and chocolate reduces the risk of cardiovascular disease (CVD).

Medications to treat obesity have unwanted side effects.

Including pharmacists in rounding teams reduces the incidence of adverse drug events (ADEs).

Two variants of chromosome 6q21 are associated with radiation therapy-induced second malignancies in pediatric Hodgkin lymphoma patients.

There is no association between HNF4A mutations and diabetes risks.

Elevated cell-free mitochondrial DNA levels are associated with mortality.

Aged patients are more susceptible to ischaemia/reperfusion injury.

KLF4 is necessary for VSMCs to gain genetic characteristics of other cell types within atherosclerotic lesions.

CD28 signals regulate trafficking of murine auto-reactive T cells into target tissues.

ITAM phosphorylation allows for the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR).

T cell receptor /CD3 microdomains are required to induce the immunologic synapse.

CD28 initiates tonic signaling in conventional T cells, which causes an exhaustion phenotype and limited efficiency.

Reduced responsiveness to interleukin-2 in regulatory T cells is associated with autoimmune diseases such as Type 1 Diabetes.

Egr3 regulates the homeostasis of B and T cells.

Egr2 regulates the homeostasis of B and T cells.

Type 1 Diabetes is associated with subtle perturbations in T reg development.

Peroxynitrite is required for induction of T cell tolerance.


Major vault protein (MVP) leads to more aggressive tumors by regulating the sorting of tumor suppressive miR-193a into extracellular vesicles (EVs).

Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection decreases dissemination of Salmonella Typhimurium from the gut.

Taxation of sugar-sweetened beverages reduced the incidence rate of type II diabetes in India.

Lmna knock-in models are appropriate for testing therapeutic approaches against Hutchinson-Gilford progeria syndrome (HGPS).

Increased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm.

Comparative transcriptome analysis identified new platelet proteins with structural features suggesting a role in platelet function.

Varenicline monotherapy is more effective after 26 weeks of treatment compared to combination nicotine replacement therapies with varenicline or bupropion.

MICAL redox enzymes regulate actin dynamics in many cell types.

Nonhypertensive people who are 55 years old have a 90% chance of developing hypertension during their lifetime.

Cancer-associated fibroblasts (CAFs) interact with cancer cells to mediate formation and activation of CAFs.

Bariatric surgery leads to negative outcomes in mental health.

Major vault protein regulates sorting of tumor suppressive miR-193a into EVs.

Low expression of miR7a does not repress target genes or exert a biological function in ovaries.

Low expression of miR7a does not repress target genes or exert a biological function in testis.

miRNAs regulate a unique suite of mRNAs to maintain homeostasis in cells.

The PPR MDA5 has twenty N-terminal CARD domains.

Glioblastoma multiforme (GBM) is characterized by extensive invasion, rapid growth, necrosis, and angiogenesis.

Ly49Q directs the organization of neutrophil polarization by regulating membrane raft functions.

Deletion of ATM and Rad3 related protein leads to acute tissue loss.

Cancer-associated fibroblasts (CAFs) are constituents of tumor microenvironments


Major vault protein regulates sorting of tumor suppressive miR-193a into EVs.

β-sheet opening occurs during pleurotolysin pore formation.

Energy balance requires hypothalamic glutamate neurotransmission.

Bariatric surgery leads to positive outcomes in mental health.

The H2A-H2B eviction defect is compensated for by other histone chaperone(s).

Charcoal shows no benefit for acute paraquat poisoning.

Differentiation of progenitor cells to myeloid cells is skewed upon activation of insulin signaling.

Rapid phosphotransfer rates are correlated with histidine kinase regulator specificity.

Increased microtubule acetylation repairs interference of axonal transport caused by LRRK2 Roc-COR domain mutations.

A deficiency of vitamin B12 decreases blood levels of homocysteine.

Active caspase-11 participate in regulating phagosome-lysosome fusion.

Deletion of ATM and Rad3 related protein is not predictive of acute tissue loss.

Activated Cdk5 phosphorylates the ATM protein in response to DNA damage.


Omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegetarians.

Adult tissue-resident macrophages stem from the embryonal yolk sac and fetal liver.

Ethanol stress lowers the expression of PSP in bacteria.

Notch signaling occurs between tumor cells and stromal cells.

MafA phosphorylation enhances its ubiquitination.

The ability of activator E2Fs in preventing cell death is limited to terminally differentiated cells.

At least 85% of patients exposed to radiation have activated markers of myofibroblasts.

CD28 initiates tonic signaling in conventional T cells, which causes an exhaustion phenotype and limited efficiency.

Roughly 55% of women with chronic pelvic pain have no underlying pathology.

Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission.

Rising temperatures caused by global warming lowers the risk of dengue fever transmission.

Rising temperatures caused by global warming increases risk of dengue fever transmission.

Eliminating the last sporadic cases of malaria requires considerable funding.

Urbanization is an important risk factor related to the transmission of dengue fever.

Nonhuman primates are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.

Eilat virus (EILV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in nonhuman primates.

The innate immune response struggles to remove small numbers of parasites.

The World Health Organization's (WHO) data collection process is biased downward by unequal selection of larger outbreaks.


Many cytokines that are produced by cancer cells also contribute to carcinogenesis.

Increased conversion of PGE 2 to PPARy ligand 15-ket-PGE 2 causes accumulation of PGE.

Increased flux of microbial products provokes immune responses.

Primary cervical cancer screening with HPV detection has lower longitudinal sensitivity than conventional cytology to detect cervical intraepithelial neoplasia grade 2.

In breast cancer, the loss of myoepithelial cells promotes the transition of ductal carcinoma in situ to invasive carcinoma.

Gastric infection with Helicobacter pylori increases risk of gastric cancer in humans.

Bariatric surgery leads to positive outcomes in mental health.

The DESMOND program demonstrates no significant impact on lifestyles outcomes.

De novo assembly of sequence data has shorter contigs than unassembled sequence data.

N348I mutations cause resistance to nevirapine.

Mitochondria play a trivial role in calcium homeostasis.

Cancer-associated fibroblasts (CAFs) interact with cancer cells to mediate formation and activation of CAFs.

Pro-inflammatory cytokines are up regulated during tumor development.

Cancer-associated fibroblasts (CAFs) have no known interaction with cancer cells in the formation and activation of CAFs.

Tumor development occurs in conjunction with upregulation of pro-inflammatory cytokines.

Cancers that initially benefit from epidermal growth factor receptor targeted therapies later become refractory through several mechanisms.

Pro-inflammatory cytokines are up repressed during tumor development.

Primary pro-inflammatory cytokines suppress secondary pro- and anti-inflammatory mediators.

Up-regulation of the p53 pathway and related molecular events speeds cancer progression.