query_id stringclasses 10 values | query stringclasses 10 values | positive_passages listlengths 1 2 | negative_passages listlengths 30 30 |
|---|---|---|---|
1215 | Instruct: Given a scientific claim, retrieve documents that support or refute the claim
Query: The effect of Lipopolysaccharides on kidney barrier function is dependent on inflammation levels. | [
{
"docid": "16355392",
"title": "Modification of kidney barrier function by the urokinase receptor",
"text": "Podocyte dysfunction, represented by foot process effacement and proteinuria, is often the starting point for progressive kidney disease. Therapies aimed at the cellular level of the disease are... | [
{
"docid": "14753395",
"title": "Structure and function of the blood–brain barrier",
"text": "Neural signalling within the central nervous system (CNS) requires a highly controlled microenvironment. Cells at three key interfaces form barriers between the blood and the CNS: the blood-brain barrier (BBB),... |
500 | Instruct: Given a scientific claim, retrieve documents that support or refute the claim
Query: Headaches are correlated with cognitive impairment. | [
{
"docid": "17930286",
"title": "Headache, migraine, and structural brain lesions and function: population based Epidemiology of Vascular Ageing-MRI study",
"text": "OBJECTIVE To evaluate the association of overall and specific headaches with volume of white matter hyperintensities, brain infarcts, and ... | [
{
"docid": "21274919",
"title": "The association between common physical impairments and dementia in low and middle income countries, and, among people with dementia, their association with cognitive function and disability. A 10/66 Dementia Research Group population-based study.",
"text": "OBJECTIVE Ch... |
383 | Instruct: Given a scientific claim, retrieve documents that support or refute the claim
Query: Epidemiological disease burden from noncommunicable diseases is more prevalent in high economic settings. | [
{
"docid": "13770184",
"title": "Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015",
"text": "BACKGROUND The Global Burden of... | [
{
"docid": "51972698",
"title": "Adapting the WHO package of essential noncommunicable disease interventions, Samoa",
"text": "Problem Samoa has been struggling to address the burden of noncommunicable diseases at the health system, community and individual levels. Approach The World Health Organization... |
588 | Instruct: Given a scientific claim, retrieve documents that support or refute the claim
Query: In transgenic mice harboring green florescent protein under the control of the Sox2 promoter, more than 50 percent of the cells with green florescent colocalize with cell proliferation markers. | [
{
"docid": "16999023",
"title": "Cell Stem Cell Article In Vivo Fate Analysis Reveals the Multipotent and Self-Renewal Capacities of Sox2 + Neural Stem Cells in the Adult Hippocampus",
"text": "To characterize the properties of adult neural stem cells (NSCs), we generated and analyzed Sox2-GFP transgeni... | [
{
"docid": "7142113",
"title": "Visualization of cell cycle in mouse embryos with Fucci2 reporter directed by Rosa26 promoter.",
"text": "Fucci technology makes possible the distinction between live cells in the G(1) and S/G(2)/M phases by dual-color imaging. This technology relies upon ubiquitylation-m... |
938 | Instruct: Given a scientific claim, retrieve documents that support or refute the claim
Query: Persister cells provide relapse resistance in cancer patients. | [
{
"docid": "26231129",
"title": "A framework for understanding and targeting residual disease in oncogene-driven solid cancers",
"text": "Molecular targeted therapy has the potential to dramatically improve survival in patients with cancer. However, complete and durable responses to targeted therapy are... | [
{
"docid": "6421792",
"title": "Activating mutations in the NT5C2 nucleotidase gene drive chemotherapy resistance in relapsed ALL",
"text": "Acute lymphoblastic leukemia (ALL) is an aggressive hematological tumor resulting from the malignant transformation of lymphoid progenitors. Despite intensive chem... |
1391 | Instruct: Given a scientific claim, retrieve documents that support or refute the claim
Query: miR-142-5P is a known regulator of raised body temperature. | [
{
"docid": "6766459",
"title": "RBM3 regulates temperature sensitive miR-142–5p and miR-143 (thermomiRs), which target immune genes and control fever",
"text": "Fever is commonly used to diagnose disease and is consistently associated with increased mortality in critically ill patients. However, the mol... | [
{
"docid": "1871499",
"title": "Genome-wide loss of 5-hmC is a novel epigenetic feature of Huntington's disease.",
"text": "5-Hydroxymethylcytosine (5-hmC) may represent a new epigenetic modification of cytosine. While the dynamics of 5-hmC during neurodevelopment have recently been reported, little is ... |
342 | Instruct: Given a scientific claim, retrieve documents that support or refute the claim
Query: Diabetic patients with acute coronary syndrome experience decreased short-term and long-term risk for bleeding events. | [
{
"docid": "5884524",
"title": "Impact of diabetes on long-term prognosis in patients with unstable angina and non-Q-wave myocardial infarction: results of the OASIS (Organization to Assess Strategies for Ischemic Syndromes) Registry.",
"text": "BACKGROUND Although unstable coronary artery disease is th... | [
{
"docid": "19308127",
"title": "In-hospital switching of oral P2Y12 inhibitor treatment in patients with acute coronary syndrome undergoing percutaneous coronary intervention: prevalence, predictors and short-term outcome.",
"text": "BACKGROUND P2Y12 inhibitor switching has appeared in clinical practic... |
418 | Instruct: Given a scientific claim, retrieve documents that support or refute the claim
Query: Fibroblast Growth Factor is a ligand which signals through receptor tyrosine kinases. | [
{
"docid": "16660256",
"title": "Sprouty1 Regulates Reversible Quiescence of a Self-Renewing Adult Muscle Stem Cell Pool during Regeneration",
"text": "Satellite cells are skeletal muscle stem cells capable of self-renewal and differentiation after transplantation, but whether they contribute to endogen... | [
{
"docid": "9315213",
"title": "Fibroblast Growth Factor 21 Prevents Atherosclerosis by Suppression of Hepatic Sterol Regulatory Element-Binding Protein-2 and Induction of Adiponectin in Mice",
"text": "BACKGROUND Fibroblast growth factor 21 (FGF21) is a metabolic hormone with pleiotropic effects on glu... |
772 | Instruct: Given a scientific claim, retrieve documents that support or refute the claim
Query: Mice are incapable of producing neutralizing antibodies in reponse to the Chikungunya virus (CHIKV) produced in mosquitos. | [
{
"docid": "24922825",
"title": "A chikungunya fever vaccine utilizing an insect-specific virus platform",
"text": "Traditionally, vaccine development involves tradeoffs between immunogenicity and safety. Live-attenuated vaccines typically offer rapid and durable immunity but have reduced safety when co... | [
{
"docid": "4373433",
"title": "Broad neutralization coverage of HIV by multiple highly potent antibodies",
"text": "Broadly neutralizing antibodies against highly variable viral pathogens are much sought after to treat or protect against global circulating viruses. Here we probed the neutralizing antib... |
997 | Instruct: Given a scientific claim, retrieve documents that support or refute the claim
Query: Pyridostatin induces double-strand breaks accumulation. | [
{
"docid": "16472469",
"title": "Targeting BRCA1 and BRCA2 Deficiencies with G-Quadruplex-Interacting Compounds",
"text": "G-quadruplex (G4)-forming genomic sequences, including telomeres, represent natural replication fork barriers. Stalled replication forks can be stabilized and restarted by homologou... | [
{
"docid": "13023410",
"title": "BCR/ABL oncogenic kinase promotes unfaithful repair of the reactive oxygen species-dependent DNA double-strand breaks.",
"text": "The oncogenic BCR/ABL tyrosine kinase induces constitutive DNA damage in Philadelphia chromosome (Ph)-positive leukemia cells. We find that B... |
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