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# Introduction
The Relationship of Urinary Metabolites of [Carbaryl](https://www.ncbi.nlm.nih.gov/mesh/D012721)/[Naphthalene](https://www.ncbi.nlm.nih.gov/mesh/C031721) and [Chlorpyrifos](https://www.ncbi.nlm.nih.gov/mesh/D004390) with Human Semen Quality
# Abstract
*In the **Abstract** section:*
Most of the genera... |
# Introduction
Effects of apoE genotype on macrophage inflammation and heme oxygenase-1 expression
# Abstract
*In the **Abstract** section:*
In order to gain a more comprehensive understanding of the aetiology of apolipoprotein E4 genotype-cardiovascular disease (CVD) associations, the impact of the apoE genotype o... |
# Introduction
Reduction of [quaternary ammonium](https://www.ncbi.nlm.nih.gov/mesh/D000644)-induced ocular surface toxicity by emulsions: an in vivo study in rabbits
# Abstract
*In the **Abstract** section:*
Purpose
To evaluate and compare the toxicological profiles of two quaternary ammonium compounds (QAC), ben... |
# Introduction
β1-6 branching of cell surface glycoproteins may contribute to uveal melanoma progression by up-regulating cell motility
# Abstract
*In the **Abstract** section:*
Purpose
This study investigated the influence of integrin expression as well as the oligosaccharide structure of surface N-glycoproteins ... |
# Introduction
Functional identification of NR2 subunits contributing to NMDA receptors on substance P receptor-expressing dorsal horn neurons
# Abstract
*In the **Abstract** section:*
NMDA receptors are important elements in pain signaling in the spinal cord dorsal horn. They are heterotetramers typically composed... |
# Introduction
Association of the [Asn](https://www.ncbi.nlm.nih.gov/mesh/D001216)306[Ser](https://www.ncbi.nlm.nih.gov/mesh/D012694) variant of the SP4 transcription factor and an intronic variant in the β-subunit of transducin with digenic disease
# Abstract
*In the **Abstract** section:*
Purpose
SP4 is a transc... |
# Introduction
Efficacy of [artesunate-amodiaquine](https://www.ncbi.nlm.nih.gov/mesh/C515299) for treating uncomplicated falciparum malaria in sub-Saharan Africa: a multi-centre analysis
# Abstract
*In the **Abstract** section:*
Background
Artesunate and amodiaquine (AS&AQ) is at present the world's second most w... |
# Introduction
[ABL-N](https://www.ncbi.nlm.nih.gov/mesh/C551742)-induced apoptosis in human breast cancer cells is partially mediated by c-Jun NH2-terminal kinase activation
# Abstract
*In the **Abstract** section:*
Introduction
The present study was designed to determine the possibility of acetylbritannilactone ... |
# Introduction
[(E)-4-(4-Hydroxy-3-methoxybenzylideneamino)-3-[1-(4-isobutylphenyl)ethyl]-1H-1,2,4-triazole-5(4H)-thione](https://www.ncbi.nlm.nih.gov/mesh/D013871)
# Abstract
*In the **Abstract** section:*
The asymmetric unit of the title compound, C22H26N4O2S, contains two crystallographically independent ... |
# Introduction
N-Carbamothioyl[amino-7-oxabicyclo[2.2.1]hept-5-ene-2,3-dicarboximide](https://www.ncbi.nlm.nih.gov/mesh/D007094)
# Abstract
*In the **Abstract** section:*
The title compound, C9H9N3O3S, comprises a racemic mixture of chiral molecules containing four stereogenic[ centres.](https://www.ncbi.nlm.nih... |
# Introduction
The evolution of farnesoid X, vitamin D, and pregnane X receptors: insights from the green-spotted pufferfish (Tetraodon nigriviridis) and other non-mammalian species
# Abstract
*In the **Abstract** section:*
Background
The farnesoid X receptor (FXR), pregnane X receptor (PXR), and vitamin D recepto... |
# Introduction
Assessment of Acetylcholinesterase Activity Using [Indoxylacetate](https://www.ncbi.nlm.nih.gov/mesh/C053640) and Comparison with the Standard Ellman’s Method
# Abstract
*In the **Abstract** section:*
Assay of acetylcholinesterase (AChE) activity plays an important role in diagnostic, detection of pe... |
# Introduction
The Chemical Composition and [Nitrogen](https://www.ncbi.nlm.nih.gov/mesh/D009584) Distribution of Chinese Yak (Maiwa) Milk
# Abstract
*In the **Abstract** section:*
The paper surveyed the chemical composition and nitrogen distribution of Maiwa yak milk, and compared the results with referenc[e compo... |
# Introduction
Green Tea [Catechins](https://www.ncbi.nlm.nih.gov/mesh/D002392) Reduce Invasive Potential of Human Melanoma Cells by Targeting COX-2, PGE2 Receptors and Epithelial-to-Mesenchymal Transition
# Abstract
*In the **Abstract** section:*
Melanoma is the most serious type of skin disease and a leading caus... |
# Introduction
Caveolin 3, Flotillin 1 and Influenza Virus Hemagglutinin Reside in Distinct Domains on the Sarcolemma of Skeletal Myofibers
# Abstract
*In the **Abstract** section:*
We examined the distribution of selected raft proteins on the sarcolemma of skeletal myofibers and the role of cholesterol environment... |
# Introduction
Modulation Role of [Abscisic Acid](https://www.ncbi.nlm.nih.gov/mesh/D000040) ([ABA](https://www.ncbi.nlm.nih.gov/mesh/D000040)) on Growth, Water Relations and [Glycinebetaine](https://www.ncbi.nlm.nih.gov/mesh/D001622) Metabolism in Two Maize (Zea mays L.) Cultivars under Drought Stress
# Abstract
*I... |
# Introduction
Trappin-2/Elafin Modulate Innate Immune Responses of Human Endometrial Epithelial Cells to [PolyI∶C](https://www.ncbi.nlm.nih.gov/mesh/D011070)
# Abstract
*In the **Abstract** section:*
Background
Upon viral recognition, innate and adaptive antiviral immune responses are initiated by genital epithel... |
# Introduction
Cortactin Is Involved in the Entry of Coxiella burnetii into Non-Phagocytic Cells
# Abstract
*In the **Abstract** section:*
Background
Cortactin is a key regulator of the actin cytoskeleton and is involved in pathogen-host cell interactions. Numerous pathogens exploit the phagocytic process and acti... |
# Introduction
[MC-12](https://www.ncbi.nlm.nih.gov/mesh/D009842), an Annexin A1-Based Peptide, Is Effective in the Treatment of Experimental Colitis
# Abstract
*In the **Abstract** section:*
Annexin A1 (ANXA1) inhibits NF-κB, a key regulator of inflammation, the common pathophysiological mechanism of inflammatory ... |
# Introduction
Differential roles of galanin on mechanical and cooling responses at the primary afferent nociceptor
# Abstract
*In the **Abstract** section:*
Background
Galanin is expressed in a small percentage of intact small diameter sensory neurons of the dorsal root ganglia and in the afferent terminals of th... |
# Introduction
Trp RNA-Binding Attenuation Protein: Modifying Symmetry and Stability of a Circular Oligomer
# Abstract
*In the **Abstract** section:*
Background
Subunit number is amongst the most important structural parameters that determine size, symmetry and geometry of a circular protein oligomer. The L-trypto... |
# Introduction
Sex- and age-specific trends in antibiotic resistance patterns of Escherichia coli urinary isolates from outpatients
# Abstract
*In the **Abstract** section:*
Background
Urinary tract infections (UTIs) are one of the most common infections treated in ambulatory care settings, however the epidemiolog... |
# Introduction
An unexpected role of neuroligin-2 in regulating KCC2 and [GABA](https://www.ncbi.nlm.nih.gov/mesh/D005680) functional switch
# Abstract
*In the **Abstract** section:*
Background
GABAA receptors are ligand-gated Cl- channels, and the intracellular Cl- concentration governs whether GABA function is e... |
# Introduction
A Pivotal Role for [Tryptophan](https://www.ncbi.nlm.nih.gov/mesh/D014364) 447 in Enzymatic Coupling of Human Endothelial Nitric Oxide Synthase (eNOS)
# Abstract
*In the **Abstract** section:*
Background: Interaction of tetrahydrobiopterin (BH4) with a key tryptophan residue in the NOS active site is... |
# Introduction
Monitoring the efficacy and safety of three [artemisinin](https://www.ncbi.nlm.nih.gov/mesh/D037621) based-combinations therapies in Senegal: results from two years surveillance
# Abstract
*In the **Abstract** section:*
Background
Malaria remains a major public health problem in developing countries... |
# Introduction
Marker-Assisted Selection for Recognizing Wheat Mutant Genotypes Carrying HMW Glutenin Alleles Related to Baking Quality
# Abstract
*In the **Abstract** section:*
Allelic diversity of HMW glutenin loci in several studies revealed that allelic combinations affect dough quality. Dx5 + Dy10 subunits are... |
# Introduction
Gla-Rich Protein Is a Potential New [Vitamin K](https://www.ncbi.nlm.nih.gov/mesh/D014812) Target in Cancer: Evidences for a Direct GRP-Mineral Interaction
# Abstract
*In the **Abstract** section:*
Gla-rich protein (GRP) was described in sturgeon as a new vitamin-K-dependent protein (VKDP) with a hig... |
# Introduction
Activation of JNK Contributes to [Evodiamine](https://www.ncbi.nlm.nih.gov/mesh/C049639)-Induced Apoptosis and G2/M Arrest in Human Colorectal Carcinoma Cells: A Structure-Activity Study of Evodiamine
# Abstract
*In the **Abstract** section:*
Evodiamine (EVO; 8,13,13b,14-tetrahydro-14-methylindolo[2′... |
# Introduction
Biantennary [oligoglycines](https://www.ncbi.nlm.nih.gov/mesh/D009842) and [glyco-oligoglycines](https://www.ncbi.nlm.nih.gov/mesh/D006020) self-associating in aqueous medium
# Abstract
*In the **Abstract** section:*
Summary
Oligoglycines designed in a star-like fashion, so-called tri- and tetraante... |
# Introduction
[Unsaturated Fatty Acid](https://www.ncbi.nlm.nih.gov/mesh/D005231), [cis-2-Decenoic Acid](https://www.ncbi.nlm.nih.gov/mesh/C052476), in Combination with Disinfectants or Antibiotics Removes Pre-Established Biofilms Formed by Food-Related Bacteria
# Abstract
*In the **Abstract** section:*
Biofilm fo... |
# Introduction
Antidiabetic Activity of [Acacia tortilis (Forsk.) Hayne ssp. raddiana Polysaccharide](https://www.ncbi.nlm.nih.gov/mesh/D011134) on [Streptozotocin](https://www.ncbi.nlm.nih.gov/mesh/D013311)-[Nicotinamide](https://www.ncbi.nlm.nih.gov/mesh/D009536) Induced Diabetic Rats
# Abstract
*In the **Abstract... |
# Introduction
[Cyclic phosphatidic acid](https://www.ncbi.nlm.nih.gov/mesh/D010712) relieves osteoarthritis symptoms
# Abstract
*In the **Abstract** section:*
Background
Cyclic phosphatidic acid (cPA) is a naturally occurring phospholipid [mediator with a unique c](https://www.ncbi.nlm.nih.gov/mesh/D010712)yc[lic... |
# Introduction
Mammalian Cytochrome P450-Dependent Metabolism of [Polychlorinated Dibenzo-p-dioxins](https://www.ncbi.nlm.nih.gov/mesh/D000072317) and Coplanar [Polychlorinated Biphenyls](https://www.ncbi.nlm.nih.gov/mesh/D011078)
# Abstract
*In the **Abstract** section:*
Polychlorinated dibenzo-p-dioxins (PCDDs) a... |
# Introduction
Characterization of [VPS34-IN1](https://www.ncbi.nlm.nih.gov/mesh/C000593572), a selective inhibitor of Vps34, reveals that the [phosphatidylinositol 3-phosphate](https://www.ncbi.nlm.nih.gov/mesh/C055525)-binding SGK3 protein kinase is a downstream target of class III phosphoinositide 3-kinase
# Abstr... |
# Introduction
Induction, Purification and Characterization of a Novel Manganese Peroxidase from Irpex lacteus CD2 and Its Application in the Decolorization of Different Types of Dye
# Abstract
*In the **Abstract** section:*
Manganese peroxidase (MnP) is the one of the important ligninolytic enzymes produced by lig... |
# Introduction
A study of the ultrasound-targeted microbubble destruction based triplex-forming oligodexinucleotide delivery system to inhibit tissue factor expression
# Abstract
*In the **Abstract** section:*
The efficiency of cellular uptake of triplex-forming oligodexinucleotides (TFO), and the inhibition of tis... |
# Introduction
Synthesis and characterization of a new photoinduced switchable [β-cyclodextrin](https://www.ncbi.nlm.nih.gov/mesh/C031215) dimer
# Abstract
*In the **Abstract** section:*
Summary
This paper reports an efficient preparation of bridged bis-β-CD AZO-CDim 1 bearing azobenzene as a linker and exhibiting... |
# Introduction
Inclusion of [trans-resveratrol](https://www.ncbi.nlm.nih.gov/mesh/C059514) in methylated [cyclodextrins](https://www.ncbi.nlm.nih.gov/mesh/D003505): synthesis and solid-state structures
# Abstract
*In the **Abstract** section:*
Summary
The phytoalexin trans-resveratrol, 5-[(1E)-2-(4-hydroxyphenyl)e... |
# Introduction
Endogenous [Prostaglandins](https://www.ncbi.nlm.nih.gov/mesh/D011453) and Afferent Sensory Nerves in Gastroprotective Effect of [Hydrogen Sulfide](https://www.ncbi.nlm.nih.gov/mesh/D006862) against Stress-Induced Gastric Lesions
# Abstract
*In the **Abstract** section:*
Hydrogen sulfide (H2S) plays ... |
# Introduction
Positive effects of the progestin [desogestrel](https://www.ncbi.nlm.nih.gov/mesh/D017135) 75 μg on migraine frequency and use of acute medication are sustained over a treatment period of 180 days
# Abstract
*In the **Abstract** section:*
Background
Premenopausal migraines frequently are associated ... |
# Introduction
[FL118](https://www.ncbi.nlm.nih.gov/mesh/C578515), a novel [camptothecin](https://www.ncbi.nlm.nih.gov/mesh/D002166) derivative, is insensitive to ABCG2 expression and shows improved efficacy in comparison with [irinotecan](https://www.ncbi.nlm.nih.gov/mesh/D000077146) in colon and lung cancer models w... |
# Introduction
GABAergic inhibition is weakened or converted into excitation in the oxytocin and vasopressin neurons of the lactating rat
# Abstract
*In the **Abstract** section:*
Background
Increased secretion of oxytocin and arginine vasopressin (AVP) from hypothalamic magnocellular neurosecretory cells (MNCs) i... |
# Introduction
A novel cancer immunotherapy based on the combination of a synthetic [carbohydrate](https://www.ncbi.nlm.nih.gov/mesh/D002241)-pulsed dendritic cell vaccine and glycoengineered cancer cells
# Abstract
*In the **Abstract** section:*
Immune tolerance to tumor-associated carbohydrate antigens (TACAs) ha... |
# Introduction
[Sulphated glycosaminoglycans](https://www.ncbi.nlm.nih.gov/mesh/D006025) and proteoglycans in the developing vertebral column of juvenile Atlantic salmon (Salmo salar)
# Abstract
*In the **Abstract** section:*
In the present study, the distribution of sulphated glycosaminoglycans (GAGs) in the devel... |
# Introduction
Formation of [Chlorotriophenoxy Radicals](https://www.ncbi.nlm.nih.gov/mesh/C042329) from Complete Series Reactions of [Chlorotriophenols](https://www.ncbi.nlm.nih.gov/mesh/C042983) with [H and OH Radicals](https://www.ncbi.nlm.nih.gov/mesh/D005609)
# Abstract
*In the **Abstract** section:*
The chlor... |
# Introduction
Adding [Sarcosine](https://www.ncbi.nlm.nih.gov/mesh/D012521) to Antipsychotic Treatment in Patients with Stable Schizophrenia Changes the Concentrations of Neuronal and Glial Metabolites in the Left Dorsolateral Prefrontal Cortex
# Abstract
*In the **Abstract** section:*
The glutamatergic system is ... |
# Introduction
The Deoxynucleoside Triphosphate Triphosphohydrolase Activity of SAMHD1 Protein Contributes to the Mitochondrial DNA Depletion Associated with Genetic Deficiency of Deoxyguanosine Kinase*
# Abstract
*In the **Abstract** section:*
Background: Deoxyguanosine kinase (dGK) deficiency causes mtDNA depleti... |
# Introduction
Global [N](https://www.ncbi.nlm.nih.gov/mesh/D009584)-linked Glycosylation is Not Significantly Impaired in Myoblasts in Congenital Myasthenic Syndromes Caused by Defective Glutamine-Fructose-6-Phosphate Transaminase 1 (GFPT1)
# Abstract
*In the **Abstract** section:*
Glutamine-fructose-6-phosphate t... |
# Introduction
[Genicunolide A, B and C](https://www.ncbi.nlm.nih.gov/mesh/D014315): three new [triterpenoids](https://www.ncbi.nlm.nih.gov/mesh/D014315) from Euphorbia geniculata
# Abstract
*In the **Abstract** section:*
Summary
Three new triterpenoids, designated as genicunolide A (1), B (2) and C (3), along wit... |
# Introduction
[Ferric carboxymaltose](https://www.ncbi.nlm.nih.gov/mesh/C522335) reduces transfusions and hospital stay in patients with colon cancer and anemia
# Abstract
*In the **Abstract** section:*
Purpose
The purpose of the study was to evaluate the efficacy of preoperative intravenous (IV) ferric carboxyma... |
# Introduction
Effects of [β-mercaptoethanol](https://www.ncbi.nlm.nih.gov/mesh/D008623) on in vitro maturation and [glutathione](https://www.ncbi.nlm.nih.gov/mesh/D005978) level of buffalo oocytes
# Abstract
*In the **Abstract** section:*
Aim:
The present study was carried out to evaluate the effect of supplement... |
# Introduction
Using a Genetically Encoded Sensor to Identify Inhibitors of Toxoplasma gondii [Ca2+](https://www.ncbi.nlm.nih.gov/mesh/D002118) Signaling*
# Abstract
*In the **Abstract** section:*
The life cycles of apicomplexan parasites progress in accordance with fluxes in cytosolic Ca2+. Such fluxes are necessa... |
# Introduction
Positive Allosteric Modulation of the Glucagon-like Peptide-1 Receptor by Diverse Electrophiles*
# Abstract
*In the **Abstract** section:*
Therapeutic intervention to activate the glucagon-like peptide-1 receptor (GLP-1R) enhances glucose-dependent insulin secretion and improves energy balance in pat... |
# Introduction
Loss of GltB Inhibits Biofilm Formation and Biocontrol Efficiency of Bacillus subtilis Bs916 by Altering the Production of [γ-Polyglutamate](https://www.ncbi.nlm.nih.gov/mesh/C511775) and Three Lipopeptides
# Abstract
*In the **Abstract** section:*
Aims
This study examined the contribution of GltB o... |
# Introduction
Pinpointing a Mechanistic Switch Between Ketoreduction and “Ene” Reduction in Short‐Chain Dehydrogenases/Reductases
# Abstract
*In the **Abstract** section:*
Abstract
Three enzymes of the Mentha essential oil biosynthetic pathway are highly homologous, namely the ketoreductases (−)‐menthone:(−)‐ment... |
# Introduction
The Study of Dynamic Potentials of Highly Excited Vibrational States of [DCP](https://www.ncbi.nlm.nih.gov/mesh/D003903): From Case Analysis to Comparative Study with [HCP](https://www.ncbi.nlm.nih.gov/mesh/D009943)
# Abstract
*In the **Abstract** section:*
The dynamic potentials of highly excited vi... |
# Introduction
The Relationship between Serum [Bilirubin](https://www.ncbi.nlm.nih.gov/mesh/D001663) and Elevated Fibrotic Indices among HBV Carriers: A Cross-Sectional Study of a Chinese Population
# Abstract
*In the **Abstract** section:*
The study probed the association between bilirubin and hepatitis B virus (H... |
# Introduction
The Production and Utilization of [GDP-glucose](https://www.ncbi.nlm.nih.gov/mesh/C100085) in the Biosynthesis of [Trehalose 6-Phosphate](https://www.ncbi.nlm.nih.gov/mesh/C082722) by Streptomyces venezuelae*
# Abstract
*In the **Abstract** section:*
Trehalose-6-phosphate synthase OtsA from streptomy... |
# Introduction
LC-MS/MS Analysis Unravels Deep Oxidation of Manganese Superoxide Dismutase in Kidney Cancer
# Abstract
*In the **Abstract** section:*
Manganese superoxide dismutase (MNSOD) is one of the major scavengers of reactive oxygen species (ROS) in mitochondria with pivotal regulatory role in ischemic disord... |
# Introduction
Neuropeptide S (NPS) variants modify the signaling and risk effects of NPS Receptor 1 (NPSR1) variants in asthma
# Abstract
*In the **Abstract** section:*
Single nucleotide polymorphisms (SNPs) close to the gain-of-function substitution, Asn(107)Ile (rs324981, A>T), in Neuro[peptide S ](https://www.n... |
# Introduction
HSP90 inhibitors potentiate [PGF2α](https://www.ncbi.nlm.nih.gov/mesh/D015237)-induced IL-6 synthesis via p38 MAP kinase in osteoblasts
# Abstract
*In the **Abstract** section:*
Heat shock protein 90 (HSP90) that is ubiquitously expressed in various tissues, is recognized to be a major molecular chap... |
# Introduction
Data driven polypharmacological drug design for lung cancer: analyses for targeting ALK, MET, and EGFR
# Abstract
*In the **Abstract** section:*
Drug design of protein kinase inhibitors is now greatly enabled by thousands of publicly available X-ray structures, extensive ligand binding data, and opti... |
# Introduction
Deconvoluting AMP-activated protein kinase (AMPK) [adenine nucleotide](https://www.ncbi.nlm.nih.gov/mesh/D000227) binding and sensing
# Abstract
*In the **Abstract** section:*
AMP-activated protein kinase (AMPK) is a central cellular energy sensor that adapts metabolism and growth to the energy state... |
# Introduction
[Glycine](https://www.ncbi.nlm.nih.gov/mesh/D005998)-Binding Site Stimulants of NMDA Receptors Alleviate Extrapyramidal Motor Disorders by Activating the Nigrostriatal Dopaminergic Pathway
# Abstract
*In the **Abstract** section:*
Dysfunction of the N-methyl-d-aspartate (NMDA) receptor has been impli... |
# Introduction
Enhanced Susceptibility of Ogg1 Mutant Mice to Multiorgan Carcinogenesis
# Abstract
*In the **Abstract** section:*
The role of deficiency of oxoguanine glycosylase 1 (Ogg1) Mmh homolog, a repair enzyme of the 8-hydroxy-2’-deoxyguanosine (8-OHdG) residue in DNA, was investigated usi[ng the multiorgan ... |
# Introduction
[Phosphine](https://www.ncbi.nlm.nih.gov/mesh/D010720)-catalyzed enantioselective [3 + 2] cycloadditions of [γ-substituted allenoates](https://www.ncbi.nlm.nih.gov/mesh/C110055) with [β-perfluoroalkyl enones](https://www.ncbi.nlm.nih.gov/mesh/D007659)†
# Abstract
*In the **Abstract** section:*
Herein... |
# Introduction
Use of [N‐methyliminodiacetic acid boronate esters](https://www.ncbi.nlm.nih.gov/mesh/C533766) in suzuki‐miyaura cross‐coupling polymerizations of [triarylamine](https://www.ncbi.nlm.nih.gov/mesh/D000588) and [fluorene](https://www.ncbi.nlm.nih.gov/mesh/C041509) monomers
# Abstract
*In the **Abstract*... |
# Introduction
NAAG Peptidase Inhibitors Act via mGluR3: Animal Models of Memory, Alzheimer’s, and [Ethanol](https://www.ncbi.nlm.nih.gov/mesh/D000431) Intoxication
# Abstract
*In the **Abstract** section:*
Glutamate carboxypeptidase II (GCPII) inactivates the peptide neurotransmitter N-acetylaspartylglutamate (NAA... |
# Introduction
Metalloradical activation of [α-formyldiazoacetates](https://www.ncbi.nlm.nih.gov/mesh/D003979) for the catalytic asymmetric radical cyclopropanation of [alkenes](https://www.ncbi.nlm.nih.gov/mesh/D000475)†
# Abstract
*In the **Abstract** section:*
For the first time, α-formyldiazoacetates (FDA), hav... |
# Introduction
CFTR-NHERF2-LPA2 Complex in the Airway and Gut Epithelia
# Abstract
*In the **Abstract** section:*
The cystic fibrosis transmembrane conductance regulator (CFTR) is a cAMP- and cGMP-regulated chloride (Cl−) and bicarbonate ([HCO3](https://www.ncbi.nlm.nih.gov/mesh/D000242)−) cha[nnel](https://www.ncb... |
# Introduction
Inhibition of RhoA/Rho kinase pathway and smooth muscle contraction by [hydrogen sulfide](https://www.ncbi.nlm.nih.gov/mesh/D006862) Inhibition of RhoA/Rho kinase pathway and smooth muscle contraction by hydrogen sulfide
# Abstract
*In the **Abstract** section:*
Abstract
Hydrogen sulfide (H2S) plays... |
# Introduction
Are boat transition states likely to occur in Cope rearrangements? A DFT study of the biogenesis of [germacranes](https://www.ncbi.nlm.nih.gov/mesh/D045788)
# Abstract
*In the **Abstract** section:*
It has been proposed that elemanes are biogenetically formed from germacranes by Cope sigmatropic rear... |
# Introduction
Organic anion transporters, OAT1 and OAT3, are crucial biopterin transporters involved in bodily distribution of [tetrahydrobiopterin](https://www.ncbi.nlm.nih.gov/mesh/C003402) and exclusion of its excess
# Abstract
*In the **Abstract** section:*
Tetrahydrobiopterin (BH4) is a common coenzyme of phe... |
# Introduction
A [Water](https://www.ncbi.nlm.nih.gov/mesh/D014867)-Bridged [Cysteine-Cysteine](https://www.ncbi.nlm.nih.gov/mesh/C046557) Redox Regulation Mechanism in Bacterial Protein Tyrosine Phosphatases
# Abstract
*In the **Abstract** section:*
Summary
The emergence of multidrug-resistant Mycobacterium tuber... |
# Introduction
Structure and Functional Analysis of Promoters from Two Liver Isoforms of CPT I in Grass Carp Ctenopharyngodon idella
# Abstract
*In the **Abstract** section:*
Carnitine palmitoyltransferase I (CPT I) is a key enzyme involved in the regulation of lipid metabolism and fatty acid β-oxidation. To unders... |
# Introduction
Protective effects of [Mentha piperita L. leaf essential oil](https://www.ncbi.nlm.nih.gov/mesh/C015424) against [CCl4](https://www.ncbi.nlm.nih.gov/mesh/D002251) induced hepatic oxidative damage and renal failure in rats
# Abstract
*In the **Abstract** section:*
Background
Mentha piperita L. is a f... |
# Introduction
Enabling high-mobility, ambipolar charge-transport in a [DPP-benzotriazole copolymer](https://www.ncbi.nlm.nih.gov/mesh/C012771) by side-chain engineering†
# Abstract
*In the **Abstract** section:*
In this article we discuss the synthesis of four new low band-gap co-polymers based on the diketopyrrol... |
# Introduction
Regulated Mesenchymal Stem Cells Mediated Colon Cancer Therapy Assessed by Reporter Gene Based Optical Imaging
# Abstract
*In the **Abstract** section:*
Colorectal cancer is the most common cancer in both men and women and the second most common cause of cancer-related deaths. Suicide gene-based ther... |
# Introduction
Folding and binding pathways of BH3-only proteins are encoded within their intrinsically disordered sequence, not templated by partner proteins
# Abstract
*In the **Abstract** section:*
Intrinsically disordered regions are present in one-third of eukaryotic proteins and are overrepresented in cellula... |
# Introduction
A WD40 Repeat Protein from Camellia sinensis Regulates [Anthocyanin](https://www.ncbi.nlm.nih.gov/mesh/D000872) and [Proanthocyanidin](https://www.ncbi.nlm.nih.gov/mesh/D044945) Accumulation through the Formation of MYB–bHLH–WD40 Ternary Complexes
# Abstract
*In the **Abstract** section:*
Flavan-3-ol... |
# Introduction
Downregulation of survivin expression and concomitant induction of apoptosis by [celecoxib](https://www.ncbi.nlm.nih.gov/mesh/D000068579) and its non-cyclooxygenase-2-inhibitory analog, [dimethyl-celecoxib](https://www.ncbi.nlm.nih.gov/mesh/C506698) ([DMC](https://www.ncbi.nlm.nih.gov/mesh/C506698)), in... |
# Introduction
FISH mapping of Philadelphia negative BCR/ABL1 positive CML
# Abstract
*In the **Abstract** section:*
Background
Chronic myeloid leukaemia (CML) is a haematopoietic stem cell disorder, almost always characterized by the presence of the Philadelphia chromosome (Ph), usually due to t(9;22)(q34;q11) or... |
# Introduction
Involvement of ER stress in retinal cell death
# Abstract
*In the **Abstract** section:*
Purpose
To clarify whether endoplasmic reticulum (ER) stress is involved in retinal cell death, using cultured retinal ganglion cells (RGC-5, a rat ganglion cell line transformed with E1A virus), and transgenic ... |
# Introduction
7′-Phenyl-1′,3′,5′,6′,7′,7a’-hexahydrodipiro[acenaphthylene-1,5′-pyrrolo[1,2-c]thiazole-6′,2′′-indane]-2,1′′(1H)-dione
# Abstract
*In the **Abstract** section:*
In the title compound, C31H23NO2S, the pyrrolidine ring adopts an envelope conformation (with the spiro C atom as the flap), while the ... |
# Introduction
[Nitric oxide](https://www.ncbi.nlm.nih.gov/mesh/D009569) activates intradomain [disulfide](https://www.ncbi.nlm.nih.gov/mesh/D004220) bond formation in the kinase loop of Akt1/PKBα after burn injury
# Abstract
*In the **Abstract** section:*
Severe burn injury is an acute inflammatory state with mass... |
# Introduction
Diabetes changes expression of genes related to [glutamate](https://www.ncbi.nlm.nih.gov/mesh/D018698) neurotransmission and transport in the Long-Evans rat retina
# Abstract
*In the **Abstract** section:*
Purpose
This study investigated changes in the transcript levels of genes related to glutamate... |
# Introduction
Crystal structure of c5321: a protective antigen present in uropathogenic Escherichia coli strains displaying an SLR fold
# Abstract
*In the **Abstract** section:*
Background
Increasing rates of antimicrobial resistance among uropathogens led, among other efforts, to the application of subtractive r... |
# Introduction
[Ropivacaine](https://www.ncbi.nlm.nih.gov/mesh/D000077212)-Induced Contraction Is Attenuated by Both Endothelial [Nitric Oxide](https://www.ncbi.nlm.nih.gov/mesh/D009569) and Voltage-Dependent Potassium Channels in Isolated Rat Aortae
# Abstract
*In the **Abstract** section:*
This study investigated... |
# Introduction
Changes in Oxidative Damage, Inflammation and [[NAD(H)](https://www.ncbi.nlm.nih.gov/mesh/D009243)] with Age in Cerebrospinal Fluid
# Abstract
*In the **Abstract** section:*
An extensive body of evidence indicates that oxidative stress and inflammation play a central role in the degenerative changes ... |
# Introduction
Low-dose angiostatic tyrosine kinase inhibitors improve photodynamic therapy for cancer: lack of vascular normalization
# Abstract
*In the **Abstract** section:*
Photodynamic therapy (PDT) is an effective clinical treatment for a number of different cancers. PDT can induce hypoxia and inflammation, p... |
# Introduction
Anti-amyloid Compounds Inhibit α-Synuclein Aggregation Induced by Protein Misfolding Cyclic Amplification (PMCA)*
# Abstract
*In the **Abstract** section:*
Background: α-Synuclein filaments can be formed in vitro, but the process is slow and unreliable, unsuitable for high throughput screening.
Resu... |
# Introduction
A Combined Experimental and Computational Study of [Vam3](https://www.ncbi.nlm.nih.gov/mesh/C000598179), a Derivative of [Resveratrol](https://www.ncbi.nlm.nih.gov/mesh/D000077185), and Syk Interaction
# Abstract
*In the **Abstract** section:*
Spleen tyrosine kinase (Syk) plays an indispensable role ... |
# Introduction
[Hypochlorous acid](https://www.ncbi.nlm.nih.gov/mesh/D006997) via [peroxynitrite](https://www.ncbi.nlm.nih.gov/mesh/D030421) activates protein kinase Cθ and insulin resistance in adipocytes
# Abstract
*In the **Abstract** section:*
We recently reported that genetic deletion of myeloperoxidase (MPO) ... |
# Introduction
[Dexamethasone](https://www.ncbi.nlm.nih.gov/mesh/D003907) Improves Heat Stroke-Induced Multiorgan Dysfunction and Damage in Rats
# Abstract
*In the **Abstract** section:*
Dexamethasone (DXM) is known as an immunosuppressive drug used for inflammation contr[ol. In the pr](https://www.ncbi.nlm.nih.gov... |
# Introduction
[Tocotrienol](https://www.ncbi.nlm.nih.gov/mesh/D024508) Rich [Palm Oil](https://www.ncbi.nlm.nih.gov/mesh/D000073878) Extract Is More Effective Than Pure [Tocotrienols](https://www.ncbi.nlm.nih.gov/mesh/D024508) at Improving Endothelium-Dependent Relaxation in the Presence of Oxidative Stress
# Abstra... |
# Introduction
Chemical Swarming: Depending on Concentration, an Amphiphilic [Ruthenium Polypyridyl Complex](https://www.ncbi.nlm.nih.gov/mesh/D011725) Induces Cell Death via Two Different Mechanisms
# Abstract
*In the **Abstract** section:*
Abstract
The crystal structure and in vitro cytotoxicity of the amphiphil... |
# Introduction
Chemosensitizing [indomethacin](https://www.ncbi.nlm.nih.gov/mesh/D007213)-conjugated [dextran](https://www.ncbi.nlm.nih.gov/mesh/D003911)-based micelles for effective delivery of [paclitaxel](https://www.ncbi.nlm.nih.gov/mesh/D017239) in resistant breast cancer therapy
# Abstract
*In the **Abstract**... |
# Introduction
Neural changes associated with cerebellar tDCS studied using MR spectroscopy
# Abstract
*In the **Abstract** section:*
Anodal cerebellar transcranial direct current stimulation (tDCS) is known to enhance motor learning, and therefore, has been suggested to hold promise as a therapeutic intervention. ... |
# Introduction
Impact of the [NO](https://www.ncbi.nlm.nih.gov/mesh/D009569)-Sensitive Guanylyl Cyclase 1 and 2 on Renal Blood Flow and Systemic Blood Pressure in Mice
# Abstract
*In the **Abstract** section:*
Nitric oxide (NO) modulates renal blood flow (RBF) and kidney function and is involved in blood pressure (... |
# Introduction
New Insight into the Octamer of TYMS Stabilized by Intermolecular [Cys43-Disulfide](https://www.ncbi.nlm.nih.gov/mesh/D003545)
# Abstract
*In the **Abstract** section:*
Thymidylate synthase (TYMS) is an essential enzyme for the de novo synthesis of deoxythymidine monophosphate (dTMP) and has been a p... |
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