context stringlengths 9 781 | question stringlengths 43 164 | answers dict | metadata stringlengths 112 167 |
|---|---|---|---|
Induction of NF-KB during monocyte differentiation by HIV type 1 infection. | Every negation cue in the text, as written. | {
"text": [],
"answer_start": []
} | {"field": "negation_cues", "group": "abstracts:91079577:0", "type": "list", "id": "abstracts:91079577:0:negation"} |
Induction of NF-KB during monocyte differentiation by HIV type 1 infection. | Every speculation cue in the text, as written. | {
"text": [],
"answer_start": []
} | {"field": "speculation_cues", "group": "abstracts:91079577:0", "type": "list", "id": "abstracts:91079577:0:speculation"} |
The production of human immunodeficiency virus type 1 (HIV-1) progeny was followed in the U937 promonocytic cell line after stimulation either with retinoic acid or PMA, and in purified human monocytes and macrophages. | Every negation cue in the text, as written. | {
"text": [],
"answer_start": []
} | {"field": "negation_cues", "group": "abstracts:91079577:1", "type": "list", "id": "abstracts:91079577:1:negation"} |
The production of human immunodeficiency virus type 1 (HIV-1) progeny was followed in the U937 promonocytic cell line after stimulation either with retinoic acid or PMA, and in purified human monocytes and macrophages. | Every speculation cue in the text, as written. | {
"text": [],
"answer_start": []
} | {"field": "speculation_cues", "group": "abstracts:91079577:1", "type": "list", "id": "abstracts:91079577:1:speculation"} |
Electrophoretic mobility shift assays and Southwestern blotting experiments were used to detect the binding of cellular transactivation factor NF-KB to the double repeat-KB enhancer sequence located in the long terminal repeat. | Every negation cue in the text, as written. | {
"text": [],
"answer_start": []
} | {"field": "negation_cues", "group": "abstracts:91079577:2", "type": "list", "id": "abstracts:91079577:2:negation"} |
Electrophoretic mobility shift assays and Southwestern blotting experiments were used to detect the binding of cellular transactivation factor NF-KB to the double repeat-KB enhancer sequence located in the long terminal repeat. | Every speculation cue in the text, as written. | {
"text": [],
"answer_start": []
} | {"field": "speculation_cues", "group": "abstracts:91079577:2", "type": "list", "id": "abstracts:91079577:2:speculation"} |
PMA treatment, and not retinoic acid treatment of the U937 cells acts in inducing NF-KB expression in the nuclei. | Every negation cue in the text, as written. | {
"text": [
"not"
],
"answer_start": [
19
]
} | {"field": "negation_cues", "group": "abstracts:91079577:3", "type": "list", "id": "abstracts:91079577:3:negation"} |
PMA treatment, and not retinoic acid treatment of the U937 cells acts in inducing NF-KB expression in the nuclei. | Every speculation cue in the text, as written. | {
"text": [],
"answer_start": []
} | {"field": "speculation_cues", "group": "abstracts:91079577:3", "type": "list", "id": "abstracts:91079577:3:speculation"} |
PMA treatment, and not retinoic acid treatment of the U937 cells acts in inducing NF-KB expression in the nuclei. | The full scope of the negation cue 'not' at [19, 22) (zero-based characters, end-exclusive). Return every scope segment. | {
"text": [
"not retinoic acid treatment of the U937 cells"
],
"answer_start": [
19
]
} | {"field": "negation_scope_0", "group": "abstracts:91079577:3", "type": "list", "id": "abstracts:91079577:3:X1.4.1", "cue_spans": [[19, 22]]} |
In nuclear extracts from monocytes or macrophages, induction of NF-KB occurred only if the cells were previously infected with HIV-1. | Every negation cue in the text, as written. | {
"text": [],
"answer_start": []
} | {"field": "negation_cues", "group": "abstracts:91079577:4", "type": "list", "id": "abstracts:91079577:4:negation"} |
In nuclear extracts from monocytes or macrophages, induction of NF-KB occurred only if the cells were previously infected with HIV-1. | Every speculation cue in the text, as written. | {
"text": [],
"answer_start": []
} | {"field": "speculation_cues", "group": "abstracts:91079577:4", "type": "list", "id": "abstracts:91079577:4:speculation"} |
When U937 cells were infected with HIV-1, no induction of NF-KB factor was detected, whereas high level of progeny virions was produced, suggesting that this factor was not required for viral replication. | Every negation cue in the text, as written. | {
"text": [
"no",
"not"
],
"answer_start": [
42,
169
]
} | {"field": "negation_cues", "group": "abstracts:91079577:5", "type": "list", "id": "abstracts:91079577:5:negation"} |
When U937 cells were infected with HIV-1, no induction of NF-KB factor was detected, whereas high level of progeny virions was produced, suggesting that this factor was not required for viral replication. | Every speculation cue in the text, as written. | {
"text": [
"suggesting"
],
"answer_start": [
137
]
} | {"field": "speculation_cues", "group": "abstracts:91079577:5", "type": "list", "id": "abstracts:91079577:5:speculation"} |
When U937 cells were infected with HIV-1, no induction of NF-KB factor was detected, whereas high level of progeny virions was produced, suggesting that this factor was not required for viral replication. | The full scope of the negation cue 'not' at [169, 172) (zero-based characters, end-exclusive). Return every scope segment. | {
"text": [
"not required for viral replication"
],
"answer_start": [
169
]
} | {"field": "negation_scope_0", "group": "abstracts:91079577:5", "type": "list", "id": "abstracts:91079577:5:X1.6.1", "cue_spans": [[169, 172]]} |
When U937 cells were infected with HIV-1, no induction of NF-KB factor was detected, whereas high level of progeny virions was produced, suggesting that this factor was not required for viral replication. | The full scope of the negation cue 'no' at [42, 44) (zero-based characters, end-exclusive). Return every scope segment. | {
"text": [
"no induction of NF-KB factor was detected"
],
"answer_start": [
42
]
} | {"field": "negation_scope_1", "group": "abstracts:91079577:5", "type": "list", "id": "abstracts:91079577:5:X1.6.3", "cue_spans": [[42, 44]]} |
When U937 cells were infected with HIV-1, no induction of NF-KB factor was detected, whereas high level of progeny virions was produced, suggesting that this factor was not required for viral replication. | The full scope of the speculation cue 'suggesting' at [137, 147) (zero-based characters, end-exclusive). Return every scope segment. | {
"text": [
"suggesting that this factor was not required for viral replication"
],
"answer_start": [
137
]
} | {"field": "speculation_scope_2", "group": "abstracts:91079577:5", "type": "list", "id": "abstracts:91079577:5:X1.6.2", "cue_spans": [[137, 147]]} |
These results indicate that in monocytic cell lineage, HIV-1 could mimic some differentiation/activation stimuli allowing nuclear NF-KB expression. | Every negation cue in the text, as written. | {
"text": [],
"answer_start": []
} | {"field": "negation_cues", "group": "abstracts:91079577:6", "type": "list", "id": "abstracts:91079577:6:negation"} |
These results indicate that in monocytic cell lineage, HIV-1 could mimic some differentiation/activation stimuli allowing nuclear NF-KB expression. | Every speculation cue in the text, as written. | {
"text": [
"indicate that",
"could"
],
"answer_start": [
14,
61
]
} | {"field": "speculation_cues", "group": "abstracts:91079577:6", "type": "list", "id": "abstracts:91079577:6:speculation"} |
These results indicate that in monocytic cell lineage, HIV-1 could mimic some differentiation/activation stimuli allowing nuclear NF-KB expression. | The full scope of the speculation cue 'could' at [61, 66) (zero-based characters, end-exclusive). Return every scope segment. | {
"text": [
"could mimic some differentiation/activation stimuli allowing nuclear NF-KB expression"
],
"answer_start": [
61
]
} | {"field": "speculation_scope_0", "group": "abstracts:91079577:6", "type": "list", "id": "abstracts:91079577:6:X1.7.1", "cue_spans": [[61, 66]]} |
These results indicate that in monocytic cell lineage, HIV-1 could mimic some differentiation/activation stimuli allowing nuclear NF-KB expression. | The full scope of the speculation cue 'indicate that' at [14, 27) (zero-based characters, end-exclusive). Return every scope segment. | {
"text": [
"indicate that in monocytic cell lineage, HIV-1 could mimic some differentiation/activation stimuli allowing nuclear NF-KB expression"
],
"answer_start": [
14
]
} | {"field": "speculation_scope_1", "group": "abstracts:91079577:6", "type": "list", "id": "abstracts:91079577:6:X1.7.2", "cue_spans": [[14, 27]]} |
Positive and negative regulation of immunoglobulin gene expression by a novel B-cell-specific enhancer element. | Every negation cue in the text, as written. | {
"text": [],
"answer_start": []
} | {"field": "negation_cues", "group": "abstracts:91094881:0", "type": "list", "id": "abstracts:91094881:0:negation"} |
Positive and negative regulation of immunoglobulin gene expression by a novel B-cell-specific enhancer element. | Every speculation cue in the text, as written. | {
"text": [],
"answer_start": []
} | {"field": "speculation_cues", "group": "abstracts:91094881:0", "type": "list", "id": "abstracts:91094881:0:speculation"} |
A new B-cell-specific enhancer element has been identified 3' of E4 and the octamerlike motifs in the human immunoglobulin heavy-chain gene enhancer. | Every negation cue in the text, as written. | {
"text": [],
"answer_start": []
} | {"field": "negation_cues", "group": "abstracts:91094881:1", "type": "list", "id": "abstracts:91094881:1:negation"} |
A new B-cell-specific enhancer element has been identified 3' of E4 and the octamerlike motifs in the human immunoglobulin heavy-chain gene enhancer. | Every speculation cue in the text, as written. | {
"text": [],
"answer_start": []
} | {"field": "speculation_cues", "group": "abstracts:91094881:1", "type": "list", "id": "abstracts:91094881:1:speculation"} |
Tandem copies of this 67-bp MnlI-AluI fragment, when fused to the chloramphenicol acetyltransferase gene driven by the conalbumin promoter, stimulated transcription in B cells but not in Jurkat T cells or HeLa cells. | Every negation cue in the text, as written. | {
"text": [
"not"
],
"answer_start": [
180
]
} | {"field": "negation_cues", "group": "abstracts:91094881:2", "type": "list", "id": "abstracts:91094881:2:negation"} |
Tandem copies of this 67-bp MnlI-AluI fragment, when fused to the chloramphenicol acetyltransferase gene driven by the conalbumin promoter, stimulated transcription in B cells but not in Jurkat T cells or HeLa cells. | Every speculation cue in the text, as written. | {
"text": [
"or"
],
"answer_start": [
202
]
} | {"field": "speculation_cues", "group": "abstracts:91094881:2", "type": "list", "id": "abstracts:91094881:2:speculation"} |
Tandem copies of this 67-bp MnlI-AluI fragment, when fused to the chloramphenicol acetyltransferase gene driven by the conalbumin promoter, stimulated transcription in B cells but not in Jurkat T cells or HeLa cells. | The full scope of the negation cue 'not' at [180, 183) (zero-based characters, end-exclusive). Return every scope segment. | {
"text": [
"not in Jurkat T cells or HeLa cells"
],
"answer_start": [
180
]
} | {"field": "negation_scope_0", "group": "abstracts:91094881:2", "type": "list", "id": "abstracts:91094881:2:X2.3.2", "cue_spans": [[180, 183]]} |
Tandem copies of this 67-bp MnlI-AluI fragment, when fused to the chloramphenicol acetyltransferase gene driven by the conalbumin promoter, stimulated transcription in B cells but not in Jurkat T cells or HeLa cells. | The full scope of the speculation cue 'or' at [202, 204) (zero-based characters, end-exclusive). Return every scope segment. | {
"text": [
"Jurkat T cells or HeLa cells"
],
"answer_start": [
187
]
} | {"field": "speculation_scope_1", "group": "abstracts:91094881:2", "type": "list", "id": "abstracts:91094881:2:X2.3.1", "cue_spans": [[202, 204]]} |
Footprinting analysis revealed that the identical sequence CCGAAACTGAAAAGG, designated E6, was protected by nuclear extracts from B cells, T cells, or HeLa cells. | Every negation cue in the text, as written. | {
"text": [],
"answer_start": []
} | {"field": "negation_cues", "group": "abstracts:91094881:3", "type": "list", "id": "abstracts:91094881:3:negation"} |
Footprinting analysis revealed that the identical sequence CCGAAACTGAAAAGG, designated E6, was protected by nuclear extracts from B cells, T cells, or HeLa cells. | Every speculation cue in the text, as written. | {
"text": [
"or"
],
"answer_start": [
148
]
} | {"field": "speculation_cues", "group": "abstracts:91094881:3", "type": "list", "id": "abstracts:91094881:3:speculation"} |
Footprinting analysis revealed that the identical sequence CCGAAACTGAAAAGG, designated E6, was protected by nuclear extracts from B cells, T cells, or HeLa cells. | The full scope of the speculation cue 'or' at [148, 150) (zero-based characters, end-exclusive). Return every scope segment. | {
"text": [
"B cells, T cells, or HeLa cells"
],
"answer_start": [
130
]
} | {"field": "speculation_scope_0", "group": "abstracts:91094881:3", "type": "list", "id": "abstracts:91094881:3:X2.4.1", "cue_spans": [[148, 150]]} |
Gel mobility shift assays using a synthetic E6 motif detected a B-cell-specific complex in addition to a ubiquitous band found also in T cells and HeLa cells. | Every negation cue in the text, as written. | {
"text": [],
"answer_start": []
} | {"field": "negation_cues", "group": "abstracts:91094881:4", "type": "list", "id": "abstracts:91094881:4:negation"} |
Gel mobility shift assays using a synthetic E6 motif detected a B-cell-specific complex in addition to a ubiquitous band found also in T cells and HeLa cells. | Every speculation cue in the text, as written. | {
"text": [],
"answer_start": []
} | {"field": "speculation_cues", "group": "abstracts:91094881:4", "type": "list", "id": "abstracts:91094881:4:speculation"} |
In agreement with the results of gel retardation assays, tandem copies of the E6 motif stimulated transcription in ARH77 and Raji cells but not in Jurkat or HeLa cells. | Every negation cue in the text, as written. | {
"text": [
"not"
],
"answer_start": [
140
]
} | {"field": "negation_cues", "group": "abstracts:91094881:5", "type": "list", "id": "abstracts:91094881:5:negation"} |
In agreement with the results of gel retardation assays, tandem copies of the E6 motif stimulated transcription in ARH77 and Raji cells but not in Jurkat or HeLa cells. | Every speculation cue in the text, as written. | {
"text": [
"or"
],
"answer_start": [
154
]
} | {"field": "speculation_cues", "group": "abstracts:91094881:5", "type": "list", "id": "abstracts:91094881:5:speculation"} |
In agreement with the results of gel retardation assays, tandem copies of the E6 motif stimulated transcription in ARH77 and Raji cells but not in Jurkat or HeLa cells. | The full scope of the negation cue 'not' at [140, 143) (zero-based characters, end-exclusive). Return every scope segment. | {
"text": [
"not in Jurkat or HeLa cells"
],
"answer_start": [
140
]
} | {"field": "negation_scope_0", "group": "abstracts:91094881:5", "type": "list", "id": "abstracts:91094881:5:X2.6.2", "cue_spans": [[140, 143]]} |
In agreement with the results of gel retardation assays, tandem copies of the E6 motif stimulated transcription in ARH77 and Raji cells but not in Jurkat or HeLa cells. | The full scope of the speculation cue 'or' at [154, 156) (zero-based characters, end-exclusive). Return every scope segment. | {
"text": [
"Jurkat or HeLa"
],
"answer_start": [
147
]
} | {"field": "speculation_scope_1", "group": "abstracts:91094881:5", "type": "list", "id": "abstracts:91094881:5:X2.6.1", "cue_spans": [[154, 156]]} |
Furthermore, a mutant E6 motif lost both in vitro binding activity and in vivo enhancer activity. | Every negation cue in the text, as written. | {
"text": [],
"answer_start": []
} | {"field": "negation_cues", "group": "abstracts:91094881:6", "type": "list", "id": "abstracts:91094881:6:negation"} |
Furthermore, a mutant E6 motif lost both in vitro binding activity and in vivo enhancer activity. | Every speculation cue in the text, as written. | {
"text": [],
"answer_start": []
} | {"field": "speculation_cues", "group": "abstracts:91094881:6", "type": "list", "id": "abstracts:91094881:6:speculation"} |
In striking contrast to the mouse Ig heavy-chain enhancer, in which the octamer motif acts as a B-cell-specific enhancer element, the human enhancer contains an octamerlike sequence with one base substitution which bound octamer-binding proteins with only very low affinity and showed no enhancer activity of its own. | Every negation cue in the text, as written. | {
"text": [
"no"
],
"answer_start": [
285
]
} | {"field": "negation_cues", "group": "abstracts:91094881:7", "type": "list", "id": "abstracts:91094881:7:negation"} |
In striking contrast to the mouse Ig heavy-chain enhancer, in which the octamer motif acts as a B-cell-specific enhancer element, the human enhancer contains an octamerlike sequence with one base substitution which bound octamer-binding proteins with only very low affinity and showed no enhancer activity of its own. | Every speculation cue in the text, as written. | {
"text": [],
"answer_start": []
} | {"field": "speculation_cues", "group": "abstracts:91094881:7", "type": "list", "id": "abstracts:91094881:7:speculation"} |
In striking contrast to the mouse Ig heavy-chain enhancer, in which the octamer motif acts as a B-cell-specific enhancer element, the human enhancer contains an octamerlike sequence with one base substitution which bound octamer-binding proteins with only very low affinity and showed no enhancer activity of its own. | The full scope of the negation cue 'no' at [285, 287) (zero-based characters, end-exclusive). Return every scope segment. | {
"text": [
"no enhancer activity of its own"
],
"answer_start": [
285
]
} | {"field": "negation_scope_0", "group": "abstracts:91094881:7", "type": "list", "id": "abstracts:91094881:7:X2.8.1", "cue_spans": [[285, 287]]} |
Interestingly, the MnlI-AluI fragment could suppress the basal-level activity of the conalbumin promoter in both Jurkat and HeLa cells. | Every negation cue in the text, as written. | {
"text": [],
"answer_start": []
} | {"field": "negation_cues", "group": "abstracts:91094881:8", "type": "list", "id": "abstracts:91094881:8:negation"} |
Interestingly, the MnlI-AluI fragment could suppress the basal-level activity of the conalbumin promoter in both Jurkat and HeLa cells. | Every speculation cue in the text, as written. | {
"text": [
"could"
],
"answer_start": [
38
]
} | {"field": "speculation_cues", "group": "abstracts:91094881:8", "type": "list", "id": "abstracts:91094881:8:speculation"} |
Interestingly, the MnlI-AluI fragment could suppress the basal-level activity of the conalbumin promoter in both Jurkat and HeLa cells. | The full scope of the speculation cue 'could' at [38, 43) (zero-based characters, end-exclusive). Return every scope segment. | {
"text": [
"could suppress the basal-level activity of the conalbumin promoter in both Jurkat and HeLa cells"
],
"answer_start": [
38
]
} | {"field": "speculation_scope_0", "group": "abstracts:91094881:8", "type": "list", "id": "abstracts:91094881:8:X2.9.1", "cue_spans": [[38, 43]]} |
Moreover, simian virus 40 enhancer activity was blocked by the MnlI-AluI fragment in HeLa cells but not in B cells. | Every negation cue in the text, as written. | {
"text": [
"not"
],
"answer_start": [
100
]
} | {"field": "negation_cues", "group": "abstracts:91094881:9", "type": "list", "id": "abstracts:91094881:9:negation"} |
Moreover, simian virus 40 enhancer activity was blocked by the MnlI-AluI fragment in HeLa cells but not in B cells. | Every speculation cue in the text, as written. | {
"text": [],
"answer_start": []
} | {"field": "speculation_cues", "group": "abstracts:91094881:9", "type": "list", "id": "abstracts:91094881:9:speculation"} |
Moreover, simian virus 40 enhancer activity was blocked by the MnlI-AluI fragment in HeLa cells but not in B cells. | The full scope of the negation cue 'not' at [100, 103) (zero-based characters, end-exclusive). Return every scope segment. | {
"text": [
"not in B cells"
],
"answer_start": [
100
]
} | {"field": "negation_scope_0", "group": "abstracts:91094881:9", "type": "list", "id": "abstracts:91094881:9:X2.10.1", "cue_spans": [[100, 103]]} |
Thus, the novel enhancer element identified in this study is probably a target site for both positive and negative factors. | Every negation cue in the text, as written. | {
"text": [],
"answer_start": []
} | {"field": "negation_cues", "group": "abstracts:91094881:10", "type": "list", "id": "abstracts:91094881:10:negation"} |
Thus, the novel enhancer element identified in this study is probably a target site for both positive and negative factors. | Every speculation cue in the text, as written. | {
"text": [
"probably"
],
"answer_start": [
61
]
} | {"field": "speculation_cues", "group": "abstracts:91094881:10", "type": "list", "id": "abstracts:91094881:10:speculation"} |
Thus, the novel enhancer element identified in this study is probably a target site for both positive and negative factors. | The full scope of the speculation cue 'probably' at [61, 69) (zero-based characters, end-exclusive). Return every scope segment. | {
"text": [
"probably a target site for both positive and negative factors"
],
"answer_start": [
61
]
} | {"field": "speculation_scope_0", "group": "abstracts:91094881:10", "type": "list", "id": "abstracts:91094881:10:X2.11.1", "cue_spans": [[61, 69]]} |
The NF kappa B independent cis-acting sequences in HIV-1 LTR responsive to T-cell activation. | Every negation cue in the text, as written. | {
"text": [],
"answer_start": []
} | {"field": "negation_cues", "group": "abstracts:91101115:0", "type": "list", "id": "abstracts:91101115:0:negation"} |
The NF kappa B independent cis-acting sequences in HIV-1 LTR responsive to T-cell activation. | Every speculation cue in the text, as written. | {
"text": [],
"answer_start": []
} | {"field": "speculation_cues", "group": "abstracts:91101115:0", "type": "list", "id": "abstracts:91101115:0:speculation"} |
The rate of transcription initiation directed by the long terminal repeat (LTR) of HIV-1 increases in response to mitogenic stimuli of T cells. | Every negation cue in the text, as written. | {
"text": [],
"answer_start": []
} | {"field": "negation_cues", "group": "abstracts:91101115:1", "type": "list", "id": "abstracts:91101115:1:negation"} |
The rate of transcription initiation directed by the long terminal repeat (LTR) of HIV-1 increases in response to mitogenic stimuli of T cells. | Every speculation cue in the text, as written. | {
"text": [],
"answer_start": []
} | {"field": "speculation_cues", "group": "abstracts:91101115:1", "type": "list", "id": "abstracts:91101115:1:speculation"} |
Here we show that the response of the HIV-1 LTR may be governed by two independent sequences located 5' to the site of transcription initiation sequences that bind either NFAT-1 or NF kappa B. | Every negation cue in the text, as written. | {
"text": [],
"answer_start": []
} | {"field": "negation_cues", "group": "abstracts:91101115:2", "type": "list", "id": "abstracts:91101115:2:negation"} |
Here we show that the response of the HIV-1 LTR may be governed by two independent sequences located 5' to the site of transcription initiation sequences that bind either NFAT-1 or NF kappa B. | Every speculation cue in the text, as written. | {
"text": [
"may"
],
"answer_start": [
48
]
} | {"field": "speculation_cues", "group": "abstracts:91101115:2", "type": "list", "id": "abstracts:91101115:2:speculation"} |
Here we show that the response of the HIV-1 LTR may be governed by two independent sequences located 5' to the site of transcription initiation sequences that bind either NFAT-1 or NF kappa B. | The full scope of the speculation cue 'may' at [48, 51) (zero-based characters, end-exclusive). Return every scope segment. | {
"text": [
"the response of the HIV-1 LTR may be governed by two independent sequences located 5' to the site of transcription initiation sequences that bind either NFAT-1 or NF kappa B"
],
"answer_start": [
18
]
} | {"field": "speculation_scope_0", "group": "abstracts:91101115:2", "type": "list", "id": "abstracts:91101115:2:X3.3.1", "cue_spans": [[48, 51]]} |
The rate of LTR-directed gene expression increased in response to treatment with either a phorbol ester or tumor necrosis factor alpha if either the NFAT-1 or NF kappa B binding sites were deleted, but failed to respond to these mitogenic stimuli if both sequences were absent. | Every negation cue in the text, as written. | {
"text": [
"failed"
],
"answer_start": [
202
]
} | {"field": "negation_cues", "group": "abstracts:91101115:3", "type": "list", "id": "abstracts:91101115:3:negation"} |
The rate of LTR-directed gene expression increased in response to treatment with either a phorbol ester or tumor necrosis factor alpha if either the NFAT-1 or NF kappa B binding sites were deleted, but failed to respond to these mitogenic stimuli if both sequences were absent. | Every speculation cue in the text, as written. | {
"text": [],
"answer_start": []
} | {"field": "speculation_cues", "group": "abstracts:91101115:3", "type": "list", "id": "abstracts:91101115:3:speculation"} |
The rate of LTR-directed gene expression increased in response to treatment with either a phorbol ester or tumor necrosis factor alpha if either the NFAT-1 or NF kappa B binding sites were deleted, but failed to respond to these mitogenic stimuli if both sequences were absent. | The full scope of the negation cue 'failed' at [202, 208) (zero-based characters, end-exclusive). Return every scope segment. | {
"text": [
"failed to respond to these mitogenic stimuli if both sequences were absent"
],
"answer_start": [
202
]
} | {"field": "negation_scope_0", "group": "abstracts:91101115:3", "type": "list", "id": "abstracts:91101115:3:X3.4.1", "cue_spans": [[202, 208]]} |
The HIV-1 mutant virus containing both NF kappa B and NFAT-1 deletion was able to replicate although at a much decreased growth rate, while the deletion of NFAT-1 alone increased the viral growth rate in Jurkat cells. | Every negation cue in the text, as written. | {
"text": [],
"answer_start": []
} | {"field": "negation_cues", "group": "abstracts:91101115:4", "type": "list", "id": "abstracts:91101115:4:negation"} |
The HIV-1 mutant virus containing both NF kappa B and NFAT-1 deletion was able to replicate although at a much decreased growth rate, while the deletion of NFAT-1 alone increased the viral growth rate in Jurkat cells. | Every speculation cue in the text, as written. | {
"text": [],
"answer_start": []
} | {"field": "speculation_cues", "group": "abstracts:91101115:4", "type": "list", "id": "abstracts:91101115:4:speculation"} |
Neither deletion of NF kappa B nor deletion of NFAT-1 decreased activation of viral replication by phorbol ester. | Every negation cue in the text, as written. | {
"text": [
"Neither",
"nor"
],
"answer_start": [
0,
31
]
} | {"field": "negation_cues", "group": "abstracts:91101115:5", "type": "list", "id": "abstracts:91101115:5:negation"} |
Neither deletion of NF kappa B nor deletion of NFAT-1 decreased activation of viral replication by phorbol ester. | Every speculation cue in the text, as written. | {
"text": [],
"answer_start": []
} | {"field": "speculation_cues", "group": "abstracts:91101115:5", "type": "list", "id": "abstracts:91101115:5:speculation"} |
Neither deletion of NF kappa B nor deletion of NFAT-1 decreased activation of viral replication by phorbol ester. | The full scope of the negation cue 'Neither' at [0, 7), 'nor' at [31, 34) (zero-based characters, end-exclusive). Return every scope segment. | {
"text": [
"Neither deletion of NF kappa B nor deletion of NFAT-1 decreased activation of viral replication by phorbol ester"
],
"answer_start": [
0
]
} | {"field": "negation_scope_0", "group": "abstracts:91101115:5", "type": "list", "id": "abstracts:91101115:5:X3.6.1", "cue_spans": [[0, 7], [31, 34]]} |
Specific depletion of the B-cell population induced by aberrant expression of human interferon regulatory factor 1 gene in transgenic mice. | Every negation cue in the text, as written. | {
"text": [],
"answer_start": []
} | {"field": "negation_cues", "group": "abstracts:91110562:0", "type": "list", "id": "abstracts:91110562:0:negation"} |
Specific depletion of the B-cell population induced by aberrant expression of human interferon regulatory factor 1 gene in transgenic mice. | Every speculation cue in the text, as written. | {
"text": [],
"answer_start": []
} | {"field": "speculation_cues", "group": "abstracts:91110562:0", "type": "list", "id": "abstracts:91110562:0:speculation"} |
Interferons (IFNs) are well known both as antiviral proteins and as potent regulators of cell growth and differentiation. | Every negation cue in the text, as written. | {
"text": [],
"answer_start": []
} | {"field": "negation_cues", "group": "abstracts:91110562:1", "type": "list", "id": "abstracts:91110562:1:negation"} |
Interferons (IFNs) are well known both as antiviral proteins and as potent regulators of cell growth and differentiation. | Every speculation cue in the text, as written. | {
"text": [],
"answer_start": []
} | {"field": "speculation_cues", "group": "abstracts:91110562:1", "type": "list", "id": "abstracts:91110562:1:speculation"} |
In fact, IFNs inhibit growth of various normal and transformed cell types. | Every negation cue in the text, as written. | {
"text": [],
"answer_start": []
} | {"field": "negation_cues", "group": "abstracts:91110562:2", "type": "list", "id": "abstracts:91110562:2:negation"} |
In fact, IFNs inhibit growth of various normal and transformed cell types. | Every speculation cue in the text, as written. | {
"text": [],
"answer_start": []
} | {"field": "speculation_cues", "group": "abstracts:91110562:2", "type": "list", "id": "abstracts:91110562:2:speculation"} |
Previously, a nuclear factor, IRF-1 (interferon regulatory factor 1), which binds to type I IFN and some IFN-inducible gene promoters, was identified and cloned. | Every negation cue in the text, as written. | {
"text": [],
"answer_start": []
} | {"field": "negation_cues", "group": "abstracts:91110562:3", "type": "list", "id": "abstracts:91110562:3:negation"} |
Previously, a nuclear factor, IRF-1 (interferon regulatory factor 1), which binds to type I IFN and some IFN-inducible gene promoters, was identified and cloned. | Every speculation cue in the text, as written. | {
"text": [],
"answer_start": []
} | {"field": "speculation_cues", "group": "abstracts:91110562:3", "type": "list", "id": "abstracts:91110562:3:speculation"} |
Since the IRF-1 gene is both virus and IFN inducible, an intriguing issue is raised as to whether the IRF-1 gene is functioning in IFN-mediated regulation of cell growth and differentiation. | Every negation cue in the text, as written. | {
"text": [],
"answer_start": []
} | {"field": "negation_cues", "group": "abstracts:91110562:4", "type": "list", "id": "abstracts:91110562:4:negation"} |
Since the IRF-1 gene is both virus and IFN inducible, an intriguing issue is raised as to whether the IRF-1 gene is functioning in IFN-mediated regulation of cell growth and differentiation. | Every speculation cue in the text, as written. | {
"text": [
"issue is raised",
"whether"
],
"answer_start": [
68,
90
]
} | {"field": "speculation_cues", "group": "abstracts:91110562:4", "type": "list", "id": "abstracts:91110562:4:speculation"} |
Since the IRF-1 gene is both virus and IFN inducible, an intriguing issue is raised as to whether the IRF-1 gene is functioning in IFN-mediated regulation of cell growth and differentiation. | The full scope of the speculation cue 'whether' at [90, 97) (zero-based characters, end-exclusive). Return every scope segment. | {
"text": [
"whether the IRF-1 gene is functioning in IFN-mediated regulation of cell growth and differentiation"
],
"answer_start": [
90
]
} | {"field": "speculation_scope_0", "group": "abstracts:91110562:4", "type": "list", "id": "abstracts:91110562:4:X4.5.1", "cue_spans": [[90, 97]]} |
Since the IRF-1 gene is both virus and IFN inducible, an intriguing issue is raised as to whether the IRF-1 gene is functioning in IFN-mediated regulation of cell growth and differentiation. | The full scope of the speculation cue 'issue is raised' at [68, 83) (zero-based characters, end-exclusive). Return every scope segment. | {
"text": [
"issue is raised as to whether the IRF-1 gene is functioning in IFN-mediated regulation of cell growth and differentiation"
],
"answer_start": [
68
]
} | {"field": "speculation_scope_1", "group": "abstracts:91110562:4", "type": "list", "id": "abstracts:91110562:4:X4.5.2", "cue_spans": [[68, 83]]} |
In this study, we generated transgenic mice carrying the human IRF-1 gene linked to the human immunoglobulin heavy-chain enhancer. | Every negation cue in the text, as written. | {
"text": [],
"answer_start": []
} | {"field": "negation_cues", "group": "abstracts:91110562:5", "type": "list", "id": "abstracts:91110562:5:negation"} |
In this study, we generated transgenic mice carrying the human IRF-1 gene linked to the human immunoglobulin heavy-chain enhancer. | Every speculation cue in the text, as written. | {
"text": [],
"answer_start": []
} | {"field": "speculation_cues", "group": "abstracts:91110562:5", "type": "list", "id": "abstracts:91110562:5:speculation"} |
In the transgenic mice, all the lymphoid tissues examined showed a dramatic reduction in the number of B lymphocytes (B cells). | Every negation cue in the text, as written. | {
"text": [],
"answer_start": []
} | {"field": "negation_cues", "group": "abstracts:91110562:6", "type": "list", "id": "abstracts:91110562:6:negation"} |
In the transgenic mice, all the lymphoid tissues examined showed a dramatic reduction in the number of B lymphocytes (B cells). | Every speculation cue in the text, as written. | {
"text": [],
"answer_start": []
} | {"field": "speculation_cues", "group": "abstracts:91110562:6", "type": "list", "id": "abstracts:91110562:6:speculation"} |
Preparation and analysis of bone marrow cells from the chimeric mice indicated that the bone marrow is the effective site for specific depletion of the B-cell population. | Every negation cue in the text, as written. | {
"text": [],
"answer_start": []
} | {"field": "negation_cues", "group": "abstracts:91110562:7", "type": "list", "id": "abstracts:91110562:7:negation"} |
Preparation and analysis of bone marrow cells from the chimeric mice indicated that the bone marrow is the effective site for specific depletion of the B-cell population. | Every speculation cue in the text, as written. | {
"text": [
"indicated that"
],
"answer_start": [
69
]
} | {"field": "speculation_cues", "group": "abstracts:91110562:7", "type": "list", "id": "abstracts:91110562:7:speculation"} |
Preparation and analysis of bone marrow cells from the chimeric mice indicated that the bone marrow is the effective site for specific depletion of the B-cell population. | The full scope of the speculation cue 'indicated that' at [69, 83) (zero-based characters, end-exclusive). Return every scope segment. | {
"text": [
"indicated that the bone marrow is the effective site for specific depletion of the B-cell population"
],
"answer_start": [
69
]
} | {"field": "speculation_scope_0", "group": "abstracts:91110562:7", "type": "list", "id": "abstracts:91110562:7:X4.8.1", "cue_spans": [[69, 83]]} |
In fact, transgenic bone marrow cells cocultured with a bone marrow-derived stromal cell line revealed an altered B-cell maturation pattern. | Every negation cue in the text, as written. | {
"text": [],
"answer_start": []
} | {"field": "negation_cues", "group": "abstracts:91110562:8", "type": "list", "id": "abstracts:91110562:8:negation"} |
In fact, transgenic bone marrow cells cocultured with a bone marrow-derived stromal cell line revealed an altered B-cell maturation pattern. | Every speculation cue in the text, as written. | {
"text": [],
"answer_start": []
} | {"field": "speculation_cues", "group": "abstracts:91110562:8", "type": "list", "id": "abstracts:91110562:8:speculation"} |
Identification and cloning of TCF-1, a T lymphocyte-specific transcription factor containing a sequence-specific HMG box. | Every negation cue in the text, as written. | {
"text": [],
"answer_start": []
} | {"field": "negation_cues", "group": "abstracts:91114695:0", "type": "list", "id": "abstracts:91114695:0:negation"} |
Identification and cloning of TCF-1, a T lymphocyte-specific transcription factor containing a sequence-specific HMG box. | Every speculation cue in the text, as written. | {
"text": [],
"answer_start": []
} | {"field": "speculation_cues", "group": "abstracts:91114695:0", "type": "list", "id": "abstracts:91114695:0:speculation"} |
CD3-epsilon expression is controlled by a downstream T lymphocyte-specific enhancer element. | Every negation cue in the text, as written. | {
"text": [],
"answer_start": []
} | {"field": "negation_cues", "group": "abstracts:91114695:1", "type": "list", "id": "abstracts:91114695:1:negation"} |
CD3-epsilon expression is controlled by a downstream T lymphocyte-specific enhancer element. | Every speculation cue in the text, as written. | {
"text": [],
"answer_start": []
} | {"field": "speculation_cues", "group": "abstracts:91114695:1", "type": "list", "id": "abstracts:91114695:1:speculation"} |
We report the identification of a T cell-specific transcription factor, TCF-1, binding to this element. | Every negation cue in the text, as written. | {
"text": [],
"answer_start": []
} | {"field": "negation_cues", "group": "abstracts:91114695:2", "type": "list", "id": "abstracts:91114695:2:negation"} |
We report the identification of a T cell-specific transcription factor, TCF-1, binding to this element. | Every speculation cue in the text, as written. | {
"text": [],
"answer_start": []
} | {"field": "speculation_cues", "group": "abstracts:91114695:2", "type": "list", "id": "abstracts:91114695:2:speculation"} |
The multimerized recognition motif of TCF-1 constituted a T cell-specific enhancer. | Every negation cue in the text, as written. | {
"text": [],
"answer_start": []
} | {"field": "negation_cues", "group": "abstracts:91114695:3", "type": "list", "id": "abstracts:91114695:3:negation"} |
The multimerized recognition motif of TCF-1 constituted a T cell-specific enhancer. | Every speculation cue in the text, as written. | {
"text": [],
"answer_start": []
} | {"field": "speculation_cues", "group": "abstracts:91114695:3", "type": "list", "id": "abstracts:91114695:3:speculation"} |
Subsequent cloning of TCF-1 identified three splice alternatives. | Every negation cue in the text, as written. | {
"text": [],
"answer_start": []
} | {"field": "negation_cues", "group": "abstracts:91114695:4", "type": "list", "id": "abstracts:91114695:4:negation"} |
Subsequent cloning of TCF-1 identified three splice alternatives. | Every speculation cue in the text, as written. | {
"text": [],
"answer_start": []
} | {"field": "speculation_cues", "group": "abstracts:91114695:4", "type": "list", "id": "abstracts:91114695:4:speculation"} |
TCF-1 contained a single DNA-binding HMG box most closely related to similar boxes in the putative mammalian sex-determining gene SRY and in the Schizosaccharomyces pombe Mc mating type gene. | Every negation cue in the text, as written. | {
"text": [],
"answer_start": []
} | {"field": "negation_cues", "group": "abstracts:91114695:5", "type": "list", "id": "abstracts:91114695:5:negation"} |
TCF-1 contained a single DNA-binding HMG box most closely related to similar boxes in the putative mammalian sex-determining gene SRY and in the Schizosaccharomyces pombe Mc mating type gene. | Every speculation cue in the text, as written. | {
"text": [
"putative"
],
"answer_start": [
90
]
} | {"field": "speculation_cues", "group": "abstracts:91114695:5", "type": "list", "id": "abstracts:91114695:5:speculation"} |
TCF-1 contained a single DNA-binding HMG box most closely related to similar boxes in the putative mammalian sex-determining gene SRY and in the Schizosaccharomyces pombe Mc mating type gene. | The full scope of the speculation cue 'putative' at [90, 98) (zero-based characters, end-exclusive). Return every scope segment. | {
"text": [
"putative mammalian sex-determining gene SRY"
],
"answer_start": [
90
]
} | {"field": "speculation_scope_0", "group": "abstracts:91114695:5", "type": "list", "id": "abstracts:91114695:5:X5.6.1", "cue_spans": [[90, 98]]} |
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