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<!DOCTYPE html>
<html lang="en">
<head>
    <meta charset="UTF-8">
    <meta name="viewport" content="width=device-width, initial-scale=1.0">
    <title>Pathology Analyzer - Agilisium Co-Lab</title>
    <link rel="stylesheet" href="styles.css?v=2">
    <link rel="stylesheet" href="analyzer.css?v=2">
</head>
<body>
    <!-- Required Banner -->
    <div class="info-banner" role="region" aria-label="Upload notice">
        <div class="banner-content">
            <svg width="20" height="20" viewBox="0 0 24 24" fill="none" xmlns="http://www.w3.org/2000/svg" aria-hidden="true">
                <circle cx="12" cy="12" r="10" stroke="currentColor" stroke-width="2"/>
                <line x1="12" y1="8" x2="12" y2="12" stroke="currentColor" stroke-width="2"/>
                <line x1="12" y1="16" x2="12.01" y2="16" stroke="currentColor" stroke-width="2"/>
            </svg>
            <span>Upload de-identified images only</span>
        </div>
    </div>
    <nav class="navbar site-nav nav--solid">
        <div class="nav-container">
            <div class="nav-logo">
                <a href="index.html" class="logo-link">
                    <img src="newlogo.webp" alt="Agilisium Co-Lab" class="logo-icon">
                    <div class="logo-text">
                        <h1>Agilisium</h1>
                        <p class="subtitle">Co-Lab</p>
                    </div>
                </a>
            </div>
            <div class="nav-links">
                <a href="index.html" class="nav-link">Home</a>
                <a href="analyzer.html" class="nav-link active" aria-current="page">Analyzer</a>
                <a href="challenges.html" class="nav-link">Challenges</a>
            </div>
            <div class="nav-actions">
                <button class="btn btn-outline">Log in</button>
            </div>
        </div>
    </nav>

    <main class="analyzer-main">
        <!-- Hero Section -->
        <div class="analyzer-hero">
            <div class="container">
                <div class="hero-content">
                    <h1 class="hero-title">AI-Powered Pathology Analysis</h1>
                    <p class="hero-subtitle">Upload your pathology images for instant cancer detection and treatment response prediction</p>
                    
                    <!-- 3-Step Process Strip -->
                    <div class="process-strip">
                        <div class="process-step">
                            <div class="step-icon">📁</div>
                            <div class="step-text">
                                <div class="step-title">Upload</div>
                                <div class="step-desc">Choose your image</div>
                            </div>
                        </div>
                        <div class="process-arrow"></div>
                        <div class="process-step">
                            <div class="step-icon">🔬</div>
                            <div class="step-text">
                                <div class="step-title">Analyze</div>
                                <div class="step-desc">AI processes image</div>
                            </div>
                        </div>
                        <div class="process-arrow"></div>
                        <div class="process-step">
                            <div class="step-icon">🎯</div>
                            <div class="step-text">
                                <div class="step-title">Results</div>
                                <div class="step-desc">Get insights & trials</div>
                            </div>
                        </div>
                    </div>
                </div>
            </div>
        </div>

        <div class="container">
            <!-- Upload Interface -->
            <div class="upload-section" id="uploadSection">
                <div class="upload-zone" id="uploadZone" tabindex="0" role="button" aria-label="Upload pathology images">
                    <div class="upload-content">
                        <div class="upload-icon">
                            <svg width="48" height="48" viewBox="0 0 24 24" fill="none" xmlns="http://www.w3.org/2000/svg">
                                <path d="M14 2H6C4.9 2 4 2.9 4 4V20C4 21.1 4.89 22 5.99 22H18C19.1 22 20 21.1 20 20V8L14 2Z" stroke="currentColor" stroke-width="2" stroke-linecap="round" stroke-linejoin="round"/>
                                <path d="M14 2V8H20" stroke="currentColor" stroke-width="2" stroke-linecap="round" stroke-linejoin="round"/>
                                <path d="M16 13H8" stroke="currentColor" stroke-width="2" stroke-linecap="round" stroke-linejoin="round"/>
                                <path d="M16 17H8" stroke="currentColor" stroke-width="2" stroke-linecap="round" stroke-linejoin="round"/>
                                <path d="M10 9H8" stroke="currentColor" stroke-width="2" stroke-linecap="round" stroke-linejoin="round"/>
                            </svg>
                        </div>
                        <h2 class="upload-title">Drop your pathology images here</h2>
                        <p class="upload-subtitle">or click to browse multiple files</p>
                        <div class="upload-formats">
                            <span class="format-tag">PNG</span>
                            <span class="format-tag">JPEG</span>
                            <span class="format-tag">WSI</span>
                        </div>
                        <div class="upload-note">PNG/JPEG/WSI • Please de-identify before upload</div>
                        <button class="browse-button" id="browseButton" type="button" aria-label="Browse files">
                            <svg width="20" height="20" viewBox="0 0 24 24" fill="none" xmlns="http://www.w3.org/2000/svg" aria-hidden="true">
                                <path d="M21 15V19C21 19.5304 20.7893 20.0391 20.4142 20.4142C20.0391 20.7893 19.5304 21 19 21H5C4.46957 21 3.96086 20.7893 3.58579 20.4142C3.21071 20.0391 3 19.5304 3 19V15" stroke="currentColor" stroke-width="2"/>
                                <polyline points="7,10 12,15 17,10" stroke="currentColor" stroke-width="2"/>
                                <line x1="12" y1="15" x2="12" y2="3" stroke="currentColor" stroke-width="2"/>
                            </svg>
                            Browse Files
                        </button>
                    </div>
                    <input type="file" id="fileInput" accept=".jpg,.jpeg,.png,.tiff" multiple aria-label="Select pathology image files">
                </div>

                <div class="file-preview" id="filePreview" style="display: none;">
                    <div class="preview-header">
                        <h3 class="preview-title">Selected Images</h3>
                        <div class="file-count" id="fileCount"></div>
                    </div>
                    <div class="preview-list" id="previewList">
                        <!-- Individual file previews will be added here -->
                    </div>
                    <div class="preview-actions">
                        <button class="btn btn-outline" id="addMoreFiles">
                            <span class="btn-icon">+</span>
                            Add More Images
                        </button>
                        <button class="btn btn-danger" id="clearAllFiles">
                            <span class="btn-icon">×</span>
                            Clear All
                        </button>
                    </div>
                </div>

                <button class="btn btn-primary analyze-btn" id="analyzeBtn" disabled>
                    <span class="btn-icon">
                        <svg width="20" height="20" viewBox="0 0 24 24" fill="none" xmlns="http://www.w3.org/2000/svg">
                            <path d="M9 12L11 14L15 10" stroke="currentColor" stroke-width="2" stroke-linecap="round" stroke-linejoin="round"/>
                            <path d="M21 12C21 16.9706 16.9706 21 12 21C7.02944 21 3 16.9706 3 12C3 7.02944 7.02944 3 12 3C16.9706 3 21 7.02944 21 12Z" stroke="currentColor" stroke-width="2"/>
                        </svg>
                    </span>
                    <span class="btn-text">Analyze Images</span>
                </button>
            </div>

            <!-- Loading State -->
            <div class="loading-section" id="loadingSection" style="display: none;">
                <div class="loading-content">
                    <div class="loading-header">
                        <div class="loading-spinner">
                            <div class="spinner-ring"></div>
                        </div>
                        <h2 class="loading-title">Analyzing your pathology images...</h2>
                        <p class="loading-subtitle">This may take a few moments while our AI processes the images</p>
                    </div>
                    
                    <!-- Progress Bar -->
                    <div class="progress-container">
                        <div class="progress-bar">
                            <div class="progress-fill" id="progressFill"></div>
                        </div>
                        <div class="progress-text" id="progressText">Starting analysis...</div>
                    </div>
                    
                    <!-- Progress Steps -->
                    <div class="progress-steps">
                        <div class="progress-step" id="step1">
                            <div class="step-indicator">
                                <div class="step-circle"></div>
                            </div>
                            <div class="step-content">
                                <div class="step-title">Image Preprocessing</div>
                                <div class="step-desc">Optimizing image quality and format</div>
                            </div>
                        </div>
                        <div class="progress-step" id="step2">
                            <div class="step-indicator">
                                <div class="step-circle"></div>
                            </div>
                            <div class="step-content">
                                <div class="step-title">Feature Extraction</div>
                                <div class="step-desc">Identifying cellular patterns and structures</div>
                            </div>
                        </div>
                        <div class="progress-step" id="step3">
                            <div class="step-indicator">
                                <div class="step-circle"></div>
                            </div>
                            <div class="step-content">
                                <div class="step-title">AI Classification</div>
                                <div class="step-desc">Analyzing cancer indicators and biomarkers</div>
                            </div>
                        </div>
                        <div class="progress-step" id="step4">
                            <div class="step-indicator">
                                <div class="step-circle"></div>
                            </div>
                            <div class="step-content">
                                <div class="step-title">Trial Matching</div>
                                <div class="step-desc">Finding relevant clinical trials</div>
                            </div>
                        </div>
                    </div>
                </div>
            </div>

            <!-- Results Layout -->
            <div class="results-section" id="resultsSection" style="display: none;">
                <div class="results-header">
                    <div class="header-content">
                        <h1 class="results-title">Analysis Complete</h1>
                        <p class="results-subtitle">Your pathology image has been successfully analyzed</p>
                    </div>
                    <div class="action-buttons">
                        <button class="btn btn-primary" id="saveCase">
                            <span class="btn-icon">💾</span>
                            <span class="btn-text">Save Case</span>
                        </button>
                        <button class="btn btn-outline" id="createChallenge">
                            <span class="btn-icon">🎯</span>
                            <span class="btn-text">Create Challenge</span>
                        </button>
                        <button class="btn btn-outline" id="exportTrials">
                            <span class="btn-icon">📊</span>
                            <span class="btn-text">Export Trials</span>
                        </button>
                        <button class="btn btn-outline" id="analyzeAnother">
                            <span class="btn-icon">🔄</span>
                            <span class="btn-text">Analyze Another</span>
                        </button>
                    </div>
                </div>

                <div class="results-grid">
                    <!-- Left Panel - Image Viewer -->
                    <div class="image-panel">
                        <div class="image-card">
                            <div class="image-header">
                                <h3 class="image-title">Pathology Images</h3>
                                <div class="image-selector" id="imageSelector" style="display: none;">
                                    <select id="imageSelect" class="image-select">
                                        <!-- Options will be populated dynamically -->
                                    </select>
                                </div>
                                <div class="image-actions">
                                    <button class="image-action" id="zoomIn" title="Zoom In">
                                        <svg width="16" height="16" viewBox="0 0 24 24" fill="none">
                                            <circle cx="11" cy="11" r="8" stroke="currentColor" stroke-width="2"/>
                                            <path d="M21 21L16.65 16.65" stroke="currentColor" stroke-width="2"/>
                                            <line x1="11" y1="8" x2="11" y2="14" stroke="currentColor" stroke-width="2"/>
                                            <line x1="8" y1="11" x2="14" y2="11" stroke="currentColor" stroke-width="2"/>
                                        </svg>
                                    </button>
                                    <button class="image-action" id="zoomOut" title="Zoom Out">
                                        <svg width="16" height="16" viewBox="0 0 24 24" fill="none">
                                            <circle cx="11" cy="11" r="8" stroke="currentColor" stroke-width="2"/>
                                            <path d="M21 21L16.65 16.65" stroke="currentColor" stroke-width="2"/>
                                            <line x1="8" y1="11" x2="14" y2="11" stroke="currentColor" stroke-width="2"/>
                                        </svg>
                                    </button>
                                    <button class="image-action" id="fitScreen" title="Fit to Screen">
                                        <svg width="16" height="16" viewBox="0 0 24 24" fill="none">
                                            <path d="M8 3H5C3.9 3 3 3.9 3 5V8M21 8V5C21 3.9 20.1 3 19 3H16M16 21H19C20.1 21 21 20.1 21 19V16M3 16V19C3 20.1 3.9 21 5 21H8" stroke="currentColor" stroke-width="2"/>
                                        </svg>
                                    </button>
                                    <button class="image-action" id="downloadOverlay" title="Download Heatmap">
                                        <svg width="16" height="16" viewBox="0 0 24 24" fill="none">
                                            <path d="M21 15V19C21 19.5304 20.7893 20.0391 20.4142 20.4142C20.0391 20.7893 19.5304 21 19 21H5C4.46957 21 3.96086 20.7893 3.58579 20.4142C3.21071 20.0391 3 19.5304 3 19V15" stroke="currentColor" stroke-width="2"/>
                                            <polyline points="7,10 12,15 17,10" stroke="currentColor" stroke-width="2"/>
                                            <line x1="12" y1="15" x2="12" y2="3" stroke="currentColor" stroke-width="2"/>
                                        </svg>
                                    </button>
                                </div>
                            </div>
                            <div class="image-container">
                                <img id="analyzedImage" alt="Analyzed pathology image" />
                                <canvas id="heatmapOverlay"></canvas>
                            </div>
                            <div class="image-info">
                                <div class="info-item">
                                    <span class="info-label">Filename:</span>
                                    <span class="info-value" id="imageFileName">sample_breast_wsi.jpg</span>
                                </div>
                                <div class="info-item">
                                    <span class="info-label">Resolution:</span>
                                    <span class="info-value" id="imageResolution">2048×2048</span>
                                </div>
                                <div class="info-item">
                                    <span class="info-label">Analyzed:</span>
                                    <span class="info-value" id="analyzedTime">2 minutes ago</span>
                                </div>
                            </div>
                        </div>
                        
                        <div class="heatmap-controls">
                            <div class="control-card">
                                <div class="control-header">
                                    <h4 class="control-title">Heatmap Overlay</h4>
                                    <label class="toggle-switch">
                                        <input type="checkbox" id="heatmapToggle" checked>
                                        <span class="toggle-slider"></span>
                                    </label>
                                </div>
                                <div class="control-content">
                                    <div class="slider-group">
                                        <label for="opacitySlider" class="slider-label">Opacity</label>
                                        <div class="slider-container">
                                            <input type="range" id="opacitySlider" min="0" max="100" value="70" aria-label="Heatmap opacity">
                                            <span class="slider-value" id="opacityValue">70%</span>
                                        </div>
                                    </div>
                                </div>
                            </div>
                        </div>
                    </div>

                    <!-- Right Panel - Results -->
                    <div class="results-panel">
                        <!-- Diagnosis Card -->
                        <div class="result-card diagnosis-card">
                            <div class="card-header">
                                <h3 class="card-title">Diagnosis</h3>
                                <div class="card-badge" id="diagnosisBadge">Cancer Detected</div>
                            </div>
                            <div class="card-content">
                                <div class="diagnosis-summary">
                                    <div class="diagnosis-item">
                                        <span class="item-label">Cancer Present:</span>
                                        <span class="item-value positive" id="cancerStatus">Yes</span>
                                    </div>
                                    <div class="diagnosis-item">
                                        <span class="item-label">Confidence:</span>
                                        <span class="item-value confidence" id="confidenceValue">94.2%</span>
                                    </div>
                                </div>
                                <div class="diagnosis-explanation" id="diagnosisExplanation">
                                    Analysis indicates invasive ductal carcinoma with well-defined tumor boundaries. High cellular density and irregular nuclear morphology support malignant classification.
                                </div>
                            </div>
                        </div>

                        <!-- Chemo Response Card -->
                        <div class="result-card chemo-card">
                            <div class="card-header">
                                <h3 class="card-title">Treatment Response</h3>
                                <div class="card-badge positive" id="chemoBadge">Likely Responsive</div>
                            </div>
                            <div class="card-content">
                                <div class="chemo-summary">
                                    <div class="chemo-item">
                                        <span class="item-label">Chemotherapy Response:</span>
                                        <span class="item-value likely" id="chemoResponse">Likely Responsive</span>
                                    </div>
                                </div>
                                <div class="chemo-explanation" id="chemoExplanation">
                                    Tumor characteristics suggest good response to standard chemotherapy protocols. High proliferation markers and hormone receptor status indicate favorable treatment outcomes.
                                </div>
                            </div>
                        </div>

                        <!-- Risk Assessment Card -->
                        <div class="result-card risk-card">
                            <div class="card-header">
                                <h3 class="card-title">Risk Assessment</h3>
                                <div class="card-badge high-risk" id="riskBadge">HIGH RISK</div>
                            </div>
                            <div class="card-content">
                                <div class="risk-summary">
                                    <div class="risk-score">
                                        <div class="score-circle">
                                            <span class="score-value" id="riskScore">87</span>
                                            <span class="score-label">/100</span>
                                        </div>
                                        <div class="score-details">
                                            <div class="score-category" id="riskCategory">HIGH RISK</div>
                                            <div class="score-description">Advanced stage with aggressive characteristics</div>
                                        </div>
                                    </div>
                                </div>
                            </div>
                        </div>

                        <!-- Clinical Trials Card -->
                        <div class="result-card trials-card">
                            <div class="card-header">
                                <h3 class="card-title">Matched Clinical Trials</h3>
                                <div class="card-badge">3 trials found</div>
                            </div>
                            <div class="card-content">
                                <div class="trial-filters">
                                    <div class="filter-group">
                                        <span class="filter-label">Phase:</span>
                                        <div class="filter-chips">
                                            <button class="filter-chip active" data-phase="all">All</button>
                                            <button class="filter-chip" data-phase="1">Phase I</button>
                                            <button class="filter-chip" data-phase="2">Phase II</button>
                                            <button class="filter-chip" data-phase="3">Phase III</button>
                                        </div>
                                    </div>
                                    <div class="filter-group">
                                        <span class="filter-label">Status:</span>
                                        <div class="filter-chips">
                                            <button class="filter-chip active" data-status="all">All</button>
                                            <button class="filter-chip" data-status="recruiting">Recruiting</button>
                                            <button class="filter-chip" data-status="active">Active</button>
                                        </div>
                                    </div>
                                    <div class="filter-group">
                                        <span class="filter-label">Distance:</span>
                                        <div class="filter-chips">
                                            <button class="filter-chip active" data-distance="all">All</button>
                                            <button class="filter-chip" data-distance="lt50">&lt; 50 km</button>
                                            <button class="filter-chip" data-distance="lt200">&lt; 200 km</button>
                                            <button class="filter-chip" data-distance="remote">Remote</button>
                                        </div>
                                    </div>
                                    <div class="filter-group">
                                        <span class="filter-label">Biomarkers:</span>
                                        <div class="filter-chips">
                                            <button class="filter-chip active" data-biomarker="all">All</button>
                                            <button class="filter-chip" data-biomarker="her2">HER2+</button>
                                            <button class="filter-chip" data-biomarker="erpr">ER/PR+</button>
                                            <button class="filter-chip" data-biomarker="tnbc">TNBC</button>
                                        </div>
                                    </div>
                                </div>
                                
                                <div class="trials-list" id="trialsList">
                                    <!-- Trials will be populated by JavaScript -->
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                </div>
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                <form id="challengeForm">
                    <div class="form-group">
                        <label for="challengeTitle">Challenge Title</label>
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                    </div>
                    <div class="form-group">
                        <label for="challengeDescription">Description</label>
                        <textarea id="challengeDescription" required placeholder="Describe the challenge objectives and requirements..."></textarea>
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                        <label for="challengeDifficulty">Difficulty Level</label>
                        <select id="challengeDifficulty" required>
                            <option value="Beginner">Beginner</option>
                            <option value="Intermediate">Intermediate</option>
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                        </select>
                    </div>
                    <div class="form-actions">
                        <button type="button" class="btn btn-secondary" id="cancelChallenge">Cancel</button>
                        <button type="submit" class="btn btn-primary">Create Challenge</button>
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