/* ===== PREMIUM ANALYZER STYLES ===== */

/* Analyzer Main Layout */
.analyzer-main {
    min-height: calc(100vh - 70px);
    background: #FFFFFF; /* Blue/white theme page background */
}

/* Hero Section */
.analyzer-hero {
    background: linear-gradient(180deg, #E8F3EE 0%, #E3F0E7 60%, #DDEBE3 100%);
    padding: 80px 0;
    color: #0F4A46; /* Dark Teal */
    position: relative;
    overflow: hidden;
}

.analyzer-hero::before {
    content: '';
    position: absolute;
    top: 0;
    left: 0;
    right: 0;
    bottom: 0;
    background: url('data:image/svg+xml,<svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100"><defs><pattern id="grain" width="100" height="100" patternUnits="userSpaceOnUse"><circle cx="25" cy="25" r="1" fill="white" opacity="0.1"/><circle cx="75" cy="75" r="1" fill="white" opacity="0.1"/><circle cx="50" cy="10" r="0.5" fill="white" opacity="0.1"/><circle cx="10" cy="60" r="0.5" fill="white" opacity="0.1"/><circle cx="90" cy="40" r="0.5" fill="white" opacity="0.1"/></pattern></defs><rect width="100" height="100" fill="url(%23grain)"/></svg>');
    opacity: 0.3;
}

.hero-content {
    position: relative;
    z-index: 1;
    text-align: center;
    max-width: 800px;
    margin: 0 auto;
}

.hero-title {
    font-size: 3.5rem;
    font-weight: 800;
    margin-bottom: 20px;
    line-height: 1.1;
    color: #0F4A46; /* Dark Teal */
}

.hero-subtitle {
    font-size: 1.25rem;
    margin-bottom: 40px;
    color: #335A57; /* Muted Text */
    line-height: 1.6;
}

/* 3-Step Process Strip */
.process-strip {
    display: flex;
    align-items: center;
    justify-content: center;
    gap: 20px;
    background: rgba(255, 255, 255, 0.8);
    backdrop-filter: blur(10px);
    border-radius: 16px;
    padding: 24px 32px;
    border: 1px solid #D9E6DF; /* Border/Divider */
    box-shadow: 0 8px 32px rgba(42, 110, 123, 0.1);
}

.process-step {
    display: flex;
    align-items: center;
    gap: 12px;
    text-align: left;
}

.step-icon {
    font-size: 24px;
    width: 48px;
    height: 48px;
    display: flex;
    align-items: center;
    justify-content: center;
    background: rgba(42, 110, 123, 0.1);
    border-radius: 12px;
    border: 1px solid rgba(42, 110, 123, 0.2);
    color: #2A6E7B; /* Primary Teal */
}

.step-text {
    display: flex;
    flex-direction: column;
    gap: 4px;
}

.step-title {
    font-weight: 600;
    font-size: 16px;
    color: #0F4A46; /* Dark Teal */
}

.step-desc {
    font-size: 14px;
    color: #335A57; /* Muted Text */
}

.process-arrow {
    font-size: 20px;
    color: #335A57; /* Muted Text */
    margin: 0 8px;
}

/* Upload Section */
.upload-section {
    max-width: 700px;
    margin: 60px auto;
    text-align: center;
}

.upload-zone {
    border: 3px dashed #D9E6DF; /* Border/Divider */
    border-radius: 24px;
    padding: 80px 40px;
    background: #FFFFFF; /* Card/Surface */
    transition: all 0.4s cubic-bezier(0.4, 0, 0.2, 1);
    cursor: pointer;
    position: relative;
    box-shadow: 0 20px 40px rgba(42, 110, 123, 0.08);
    overflow: hidden;
}

.upload-zone::before {
    content: '';
    position: absolute;
    top: 0;
    left: 0;
    right: 0;
    bottom: 0;
    background: linear-gradient(135deg, #F1F7F4 0%, #ffffff 100%);
    opacity: 0;
    transition: opacity 0.3s ease;
}

.upload-zone:hover::before,
.upload-zone:focus::before {
    opacity: 1;
}

.upload-zone:hover,
.upload-zone:focus {
    border-color: #2A6E7B; /* Primary Teal */
    background: #F1F7F4; /* Mint Light */
    transform: translateY(-8px);
    box-shadow: 0 32px 64px rgba(42, 110, 123, 0.15);
}

.upload-zone.drag-over {
    border-color: #2A6E7B; /* Primary Teal */
    background: #F1F7F4; /* Mint Light */
    transform: scale(1.02);
}

.upload-content {
    pointer-events: none;
    position: relative;
    z-index: 1;
}

.upload-icon {
    color: #2A6E7B; /* Primary Teal */
    margin-bottom: 24px;
    transition: transform 0.3s ease;
}

.upload-zone:hover .upload-icon {
    transform: scale(1.1);
}

.upload-title {
    font-size: 28px;
    margin-bottom: 12px;
    color: #0F4A46; /* Dark Teal */
    font-weight: 700;
    line-height: 1.2;
}

.upload-subtitle {
    color: #335A57; /* Muted Text */
    margin-bottom: 24px;
    font-size: 16px;
}

.upload-formats {
    display: flex;
    justify-content: center;
    gap: 8px;
    margin-bottom: 16px;
}

.format-tag {
    background: #F1F7F4; /* Mint Light */
    color: #2A6E7B; /* Primary Teal */
    padding: 6px 12px;
    border-radius: 12px;
    font-size: 14px;
    font-weight: 500;
    border: 1px solid #D9E6DF; /* Border/Divider */
}

.upload-note {
    color: #64748b; /* Slate */
    font-size: 14px;
    font-style: italic;
    margin-bottom: 20px;
}

#fileInput {
    position: absolute;
    top: 0;
    left: 0;
    width: 100%;
    height: 100%;
    opacity: 0;
    cursor: pointer;
}

/* File Preview */
.file-preview {
    margin: 32px 0;
    animation: slideInUp 0.4s ease-out;
}

@keyframes slideInUp {
    from {
        opacity: 0;
        transform: translateY(20px);
    }
    to {
        opacity: 1;
        transform: translateY(0);
    }
}

/* Multiple File Preview Styles */
.preview-header {
    display: flex;
    justify-content: space-between;
    align-items: center;
    margin-bottom: 16px;
}

.preview-title {
    color: #0F4A46; /* Dark Teal */
    font-size: 18px;
    font-weight: 600;
    margin: 0;
}

.file-count {
    background: #2A6E7B; /* Primary Teal */
    color: #FFFFFF;
    padding: 4px 12px;
    border-radius: 12px;
    font-size: 14px;
    font-weight: 600;
}

.preview-list {
    display: flex;
    flex-direction: column;
    gap: 12px;
    margin-bottom: 20px;
}

.preview-item {
    background: #FFFFFF; /* Card/Surface */
    border-radius: 16px;
    border: 1px solid #D9E6DF; /* Border/Divider */
    box-shadow: 0 4px 12px rgba(42, 110, 123, 0.06);
    padding: 16px;
    display: flex;
    align-items: center;
    gap: 12px;
    transition: all 0.3s ease;
}

.preview-item:hover {
    box-shadow: 0 8px 20px rgba(42, 110, 123, 0.12);
    border-color: #2A6E7B; /* Primary Teal */
}

.preview-icon {
    color: #2A6E7B; /* Primary Teal */
    flex-shrink: 0;
}

.preview-details {
    flex: 1;
    min-width: 0;
}

.file-name {
    color: #0F4A46; /* Dark Teal */
    font-weight: 600;
    font-size: 14px;
    margin-bottom: 4px;
    white-space: nowrap;
    overflow: hidden;
    text-overflow: ellipsis;
}

.file-meta {
    display: flex;
    gap: 12px;
    align-items: center;
}

.file-size {
    color: #335A57; /* Muted Text */
    font-size: 12px;
}

.file-status {
    color: #2A6E7B; /* Primary Teal */
    font-size: 12px;
    font-weight: 500;
}

.remove-file {
    background: #dc2626;
    color: #FFFFFF;
    border: none;
    border-radius: 8px;
    padding: 8px;
    cursor: pointer;
    transition: all 0.3s ease;
    flex-shrink: 0;
}

.remove-file:hover {
    background: #b91c1c;
    transform: scale(1.05);
}

.preview-actions {
    display: flex;
    gap: 12px;
    justify-content: center;
    padding-top: 16px;
    border-top: 1px solid #D9E6DF; /* Border/Divider */
}

.preview-actions .btn {
    padding: 10px 20px;
    font-size: 14px;
}

.preview-actions .btn-icon {
    margin-right: 8px;
    font-weight: bold;
}

.preview-card {
    background: #FFFFFF; /* Card/Surface */
    border-radius: 20px;
    border: 1px solid #D9E6DF; /* Border/Divider */
    box-shadow: 0 8px 24px rgba(42, 110, 123, 0.08);
    padding: 24px;
    display: flex;
    align-items: center;
    gap: 16px;
    transition: all 0.3s ease;
}

.preview-card:hover {
    box-shadow: 0 12px 32px rgba(42, 110, 123, 0.12);
    transform: translateY(-2px);
}

.preview-icon {
    color: #2A6E7B; /* Primary Teal */
    flex-shrink: 0;
}

.preview-details {
    flex: 1;
    text-align: left;
}

.file-name {
    font-weight: 600;
    color: #0F4A46; /* Dark Teal */
    margin-bottom: 4px;
    font-size: 16px;
}

.file-meta {
    display: flex;
    align-items: center;
    gap: 12px;
    font-size: 14px;
}

.file-size {
    color: #335A57; /* Muted Text */
}

.file-status {
    color: #2A6E7B; /* Primary Teal */
    font-weight: 500;
}

.remove-file {
    width: 36px;
    height: 36px;
    border-radius: 50%;
    display: flex;
    align-items: center;
    justify-content: center;
    background: #fef2f2;
    color: #dc2626;
    border: 1px solid #fecaca;
    cursor: pointer;
    transition: all 0.3s ease;
    flex-shrink: 0;
}

.remove-file:hover {
    background: #dc2626;
    color: white;
    transform: scale(1.1);
}

.analyze-btn {
    width: 100%;
    max-width: 240px;
    margin-top: 32px;
    padding: 16px 32px;
    font-size: 16px;
    font-weight: 600;
    border-radius: 16px;
    display: flex;
    align-items: center;
    justify-content: center;
    gap: 8px;
    transition: all 0.3s ease;
}

.analyze-btn:disabled {
    opacity: 0.5;
    cursor: not-allowed;
    transform: none !important;
}

.btn-icon {
    display: flex;
    align-items: center;
    justify-content: center;
}

.btn-text {
    font-weight: 600;
}

/* Loading Section */
.loading-section {
    max-width: 700px;
    margin: 80px auto;
    text-align: center;
}

.loading-content {
    background: #FFFFFF; /* Card/Surface */
    border-radius: 24px;
    padding: 60px 40px;
    box-shadow: 0 20px 40px rgba(0, 0, 0, 0.06);
    border: 1px solid #E2E8F0; /* Border/Divider */
}

.loading-header {
    margin-bottom: 40px;
}

.loading-spinner {
    margin-bottom: 24px;
}

.spinner-ring {
    width: 60px;
    height: 60px;
    border: 4px solid #F1F7F4; /* Mint Light */
    border-top: 4px solid #2A6E7B; /* Primary Teal */
    border-radius: 50%;
    animation: spin 1s linear infinite;
    margin: 0 auto;
}

@keyframes spin {
    0% { transform: rotate(0deg); }
    100% { transform: rotate(360deg); }
}

.loading-title {
    font-size: 32px;
    margin-bottom: 16px;
    color: #0F4A46; /* Dark Teal */
    font-weight: 700;
}

.loading-subtitle {
    color: #335A57; /* Muted Text */
    font-size: 16px;
    line-height: 1.6;
}

/* Progress Bar */
.progress-container {
    margin-bottom: 40px;
}

.progress-bar {
    width: 100%;
    height: 8px;
    background: #E2E8F0; /* light gray */
    border-radius: 4px;
    overflow: hidden;
    margin-bottom: 12px;
}

.progress-fill {
    height: 100%;
    background: linear-gradient(90deg, #0B5ED7 0%, #0A58CA 100%);
    border-radius: 4px;
    transition: width 0.8s ease;
    width: 0%;
}

.progress-text {
    color: #335A57; /* Muted Text */
    font-size: 14px;
    font-weight: 500;
}

/* Progress Steps */
.progress-steps {
    display: flex;
    flex-direction: column;
    gap: 16px;
    max-width: 500px;
    margin: 0 auto;
}

.progress-step {
    display: flex;
    align-items: center;
    gap: 16px;
    padding: 20px 24px;
    background: #F1F7F4; /* Mint Light */
    border: 2px solid #D9E6DF; /* Border/Divider */
    border-radius: 16px;
    transition: all 0.4s ease;
    text-align: left;
}

.progress-step.active {
    background: rgba(42, 110, 123, 0.1);
    border-color: #2A6E7B; /* Primary Teal */
    transform: translateX(8px);
    box-shadow: 0 4px 12px rgba(42, 110, 123, 0.15);
}

.progress-step.completed {
    background: #f0fdf4;
    border-color: #22c55e;
}

.step-indicator {
    flex-shrink: 0;
}

.step-circle {
    width: 24px;
    height: 24px;
    border-radius: 50%;
    background: #D9E6DF; /* Border/Divider */
    border: 2px solid #D9E6DF; /* Border/Divider */
    transition: all 0.3s ease;
}

.progress-step.active .step-circle {
    background: #2A6E7B; /* Primary Teal */
    border-color: #2A6E7B; /* Primary Teal */
    animation: pulse 2s infinite;
}

.progress-step.completed .step-circle {
    background: #22c55e;
    border-color: #22c55e;
}

.progress-step.completed .step-circle::after {
    content: '✓';
    color: white;
    font-size: 12px;
    font-weight: bold;
    display: flex;
    align-items: center;
    justify-content: center;
    height: 100%;
}

@keyframes pulse {
    0%, 100% { transform: scale(1); }
    50% { transform: scale(1.1); }
}

.step-content {
    flex: 1;
}

.step-title {
    font-weight: 600;
    color: #0F4A46; /* Dark Teal */
    margin-bottom: 4px;
    font-size: 16px;
}

.step-desc {
    color: #335A57; /* Muted Text */
    font-size: 14px;
    line-height: 1.4;
}

/* Results Section */
.results-section {
    margin-top: 60px;
    animation: fadeInUp 0.6s ease-out;
}

@keyframes fadeInUp {
    from {
        opacity: 0;
        transform: translateY(30px);
    }
    to {
        opacity: 1;
        transform: translateY(0);
    }
}

.results-header {
    display: flex;
    justify-content: space-between;
    align-items: flex-start;
    margin-bottom: 48px;
    flex-wrap: wrap;
    gap: 24px;
    padding: 0 20px;
}

.header-content {
    flex: 1;
}

.results-title {
    font-size: 36px;
    color: #0F4A46; /* Dark Teal */
    font-weight: 800;
    margin-bottom: 8px;
    line-height: 1.2;
}

.results-subtitle {
    color: #335A57; /* Muted Text */
    font-size: 16px;
    line-height: 1.5;
}

.action-buttons {
    display: flex;
    gap: 12px;
    flex-wrap: wrap;
    align-items: center;
}

.action-buttons .btn {
    display: flex;
    align-items: center;
    gap: 8px;
    padding: 12px 20px;
    border-radius: 12px;
    font-weight: 600;
    transition: all 0.3s ease;
}

.results-grid {
    display: grid;
    grid-template-columns: 1fr 1fr;
    gap: 48px;
    max-width: 1400px;
    margin: 0 auto;
    padding: 0 20px;
}

/* Browse button (blue theme) */
.browse-button {
    background: #0B5ED7; /* Primary Blue */
    color: #FFFFFF;
    border: none;
    border-radius: 12px;
    padding: 12px 24px;
    font-size: 14px;
    font-weight: 700;
    cursor: pointer;
    transition: all 0.3s ease;
    display: inline-flex;
    align-items: center;
    gap: 8px;
    margin-top: 16px;
}

.browse-button:hover {
    background: #0A58CA;
    transform: translateY(-1px);
    box-shadow: 0 8px 20px rgba(11, 94, 215, 0.25);
}

.browse-button:active { transform: translateY(0); }

/* Image Panel */
.image-panel {
    display: flex;
    flex-direction: column;
    gap: 24px;
}

.image-card {
    background: #FFFFFF; /* Card/Surface */
    border-radius: 24px;
    border: 1px solid #E2E8F0; /* Border/Divider */
    box-shadow: 0 12px 32px rgba(0, 0, 0, 0.06);
    overflow: hidden;
    transition: all 0.3s ease;
}

.image-card:hover {
    box-shadow: 0 16px 40px rgba(42, 110, 123, 0.12);
}

.image-header {
    display: flex;
    justify-content: space-between;
    align-items: center;
    padding: 24px 24px 0 24px;
    margin-bottom: 20px;
}

.image-title {
    font-size: 20px;
    font-weight: 700;
    color: #0F4A46; /* Dark Teal */
}

.image-selector {
    margin-left: 16px;
}

.image-select {
    background: #FFFFFF; /* Card/Surface */
    border: 1px solid #D9E6DF; /* Border/Divider */
    border-radius: 8px;
    padding: 8px 12px;
    color: #0F4A46; /* Dark Teal */
    font-size: 14px;
    font-weight: 500;
    cursor: pointer;
    transition: all 0.3s ease;
}

.image-select:focus {
    outline: none;
    border-color: #2A6E7B; /* Primary Teal */
    box-shadow: 0 0 0 3px rgba(42, 110, 123, 0.1);
}

.image-actions {
    display: flex;
    gap: 8px;
}

.image-action {
    width: 36px;
    height: 36px;
    border-radius: 8px;
    border: 1px solid #E2E8F0; /* Border/Divider */
    background: #F8FAFC; /* light */
    color: #1f2937; /* gray-800 */
    display: flex;
    align-items: center;
    justify-content: center;
    cursor: pointer;
    transition: all 0.3s ease;
}

.image-action:hover {
    background: #0B5ED7; /* Blue */
    color: white;
    border-color: #0B5ED7; /* Blue */
    transform: scale(1.05);
}

.image-container {
    position: relative;
    border-radius: 12px;
    overflow: hidden;
    background: #F1F7F4; /* Mint Light */
    margin: 0 24px 24px 24px;
    aspect-ratio: 1;
}

#analyzedImage {
    width: 100%;
    height: 100%;
    object-fit: cover;
    display: block;
    transition: transform 0.3s ease;
}

#heatmapOverlay {
    position: absolute;
    top: 0;
    left: 0;
    width: 100%;
    height: 100%;
    pointer-events: none;
    transition: opacity 0.3s ease;
}

.image-info {
    display: grid;
    grid-template-columns: repeat(auto-fit, minmax(120px, 1fr));
    gap: 16px;
    padding: 0 24px 24px 24px;
}

.info-item {
    display: flex;
    flex-direction: column;
    gap: 4px;
}

.info-label {
    font-size: 12px;
    color: #335A57; /* Muted Text */
    font-weight: 500;
    text-transform: uppercase;
    letter-spacing: 0.5px;
}

.info-value {
    font-size: 14px;
    color: #0F4A46; /* Dark Teal */
    font-weight: 600;
}

/* Heatmap Controls */
.heatmap-controls {
    background: #FFFFFF; /* Card/Surface */
    border-radius: 20px;
    border: 1px solid #D9E6DF; /* Border/Divider */
    box-shadow: 0 8px 24px rgba(42, 110, 123, 0.06);
    overflow: hidden;
}

.control-card {
    padding: 24px;
}

.control-header {
    display: flex;
    justify-content: space-between;
    align-items: center;
    margin-bottom: 20px;
}

.control-title {
    font-size: 16px;
    font-weight: 600;
    color: #0F4A46; /* Dark Teal */
}

.toggle-switch {
    position: relative;
    display: inline-block;
    width: 48px;
    height: 24px;
}

.toggle-switch input {
    opacity: 0;
    width: 0;
    height: 0;
}

.toggle-slider {
    position: absolute;
    cursor: pointer;
    top: 0;
    left: 0;
    right: 0;
    bottom: 0;
    background-color: #D9E6DF; /* Border/Divider */
    transition: 0.3s;
    border-radius: 24px;
}

.toggle-slider:before {
    position: absolute;
    content: "";
    height: 18px;
    width: 18px;
    left: 3px;
    bottom: 3px;
    background-color: white;
    transition: 0.3s;
    border-radius: 50%;
}

input:checked + .toggle-slider {
    background-color: #2A6E7B; /* Primary Teal */
}

input:checked + .toggle-slider:before {
    transform: translateX(24px);
}

.control-content {
    display: flex;
    flex-direction: column;
    gap: 16px;
}

.slider-group {
    display: flex;
    flex-direction: column;
    gap: 8px;
}

.slider-label {
    font-size: 14px;
    font-weight: 500;
    color: #335A57; /* Muted Text */
}

.slider-container {
    display: flex;
    align-items: center;
    gap: 12px;
}

#opacitySlider {
    flex: 1;
    height: 6px;
    border-radius: 3px;
    background: #D9E6DF; /* Border/Divider */
    outline: none;
    -webkit-appearance: none;
}

#opacitySlider::-webkit-slider-thumb {
    -webkit-appearance: none;
    appearance: none;
    width: 20px;
    height: 20px;
    border-radius: 50%;
    background: #2A6E7B; /* Primary Teal */
    cursor: pointer;
    box-shadow: 0 2px 4px rgba(42, 110, 123, 0.3);
}

#opacitySlider::-moz-range-thumb {
    width: 20px;
    height: 20px;
    border-radius: 50%;
    background: #2A6E7B; /* Primary Teal */
    cursor: pointer;
    border: none;
    box-shadow: 0 2px 4px rgba(42, 110, 123, 0.3);
}

.slider-value {
    color: #335A57; /* Muted Text */
    font-weight: 600;
    font-size: 14px;
    min-width: 40px;
    text-align: right;
}

/* Results Panel */
.results-panel {
    display: flex;
    flex-direction: column;
    gap: 24px;
}

/* Footer Disclaimer */
.disclaimer-footer {
    background: #F8FAFC;
    border-top: 1px solid #E2E8F0;
    padding: 20px 0;
    text-align: center;
    margin-top: 60px;
}

.disclaimer-footer p {
    color: #334155;
    font-size: 14px;
    margin: 0;
}

.result-card {
    background: #FFFFFF; /* Card/Surface */
    border-radius: 20px;
    border: 1px solid #D9E6DF; /* Border/Divider */
    box-shadow: 0 8px 24px rgba(42, 110, 123, 0.06);
    overflow: hidden;
    transition: all 0.3s ease;
}

.result-card:hover {
    box-shadow: 0 12px 32px rgba(42, 110, 123, 0.1);
    transform: translateY(-2px);
}

.card-header {
    display: flex;
    justify-content: space-between;
    align-items: center;
    padding: 24px 24px 0 24px;
    margin-bottom: 20px;
}

.card-title {
    font-size: 18px;
    font-weight: 700;
    color: #0F4A46; /* Dark Teal */
}

.card-badge {
    padding: 6px 12px;
    border-radius: 12px;
    font-size: 12px;
    font-weight: 600;
    text-transform: uppercase;
    letter-spacing: 0.5px;
}

.diagnosis-card .card-badge {
    background: #fef2f2;
    color: #dc2626;
    border: 1px solid #fecaca;
}

.chemo-card .card-badge.positive {
    background: #f0fdf4;
    color: #22c55e;
    border: 1px solid #bbf7d0;
}

.trials-card .card-badge {
    background: rgba(11, 94, 215, 0.1);
    color: #0B5ED7; /* Primary Blue */
    border: 1px solid rgba(11, 94, 215, 0.2);
}

.card-content {
    padding: 0 24px 24px 24px;
}

/* Diagnosis Card */
.diagnosis-summary {
    display: flex;
    flex-direction: column;
    gap: 16px;
    margin-bottom: 20px;
}

.diagnosis-item {
    display: flex;
    justify-content: space-between;
    align-items: center;
    padding: 12px 16px;
    background: #F8FAFC; /* light */
    border-radius: 12px;
    border: 1px solid #E2E8F0; /* Border/Divider */
}

.item-label {
    font-weight: 500;
    color: #335A57; /* Muted Text */
    font-size: 14px;
}

.item-value {
    font-weight: 700;
    font-size: 16px;
}

.item-value.positive {
    color: #dc2626;
}

.item-value.confidence {
    color: #22c55e;
}

.item-value.likely {
    color: #22c55e;
}

.diagnosis-explanation,
.chemo-explanation {
    color: #335A57; /* Muted Text */
    line-height: 1.6;
    font-size: 14px;
    padding: 16px;
    background: #F1F7F4; /* Mint Light */
    border-radius: 12px;
    border-left: 4px solid #2A6E7B; /* Primary Teal */
}

/* Chemo Response Card */
.chemo-summary {
    margin-bottom: 20px;
}

.chemo-item {
    display: flex;
    justify-content: space-between;
    align-items: center;
    padding: 12px 16px;
    background: #f8fafc;
    border-radius: 12px;
    border: 1px solid #e2e8f0;
}

/* Clinical Trials Card */
.trial-filters {
    display: flex;
    flex-direction: column;
    gap: 16px;
    margin-bottom: 24px;
}

.filter-group {
    display: flex;
    align-items: center;
    gap: 12px;
    flex-wrap: wrap;
}

.filter-label {
    font-size: 14px;
    font-weight: 500;
    color: #335A57; /* Muted Text */
    min-width: 60px;
}

.filter-chips {
    display: flex;
    gap: 8px;
    flex-wrap: wrap;
}

.filter-chip {
    padding: 8px 16px;
    border: 1px solid #e2e8f0;
    background: #ffffff;
    color: #335A57; /* Muted Text */
    border-radius: 20px;
    font-size: 14px;
    font-weight: 500;
    cursor: pointer;
    transition: all 0.3s ease;
}

.filter-chip:hover {
    border-color: #2A6E7B; /* Primary Teal */
    color: #2A6E7B; /* Primary Teal */
    background: rgba(42, 110, 123, 0.1);
}

.filter-chip.active {
    background: #2A6E7B; /* Primary Teal */
    color: #ffffff;
    border-color: #2A6E7B; /* Primary Teal */
}

.trials-list {
    display: flex;
    flex-direction: column;
    gap: 16px;
}

.trial-card {
    background: #F1F7F4; /* Mint Light */
    border: 1px solid #D9E6DF; /* Border/Divider */
    border-radius: 12px;
    padding: 20px;
    transition: all 0.3s ease;
}

.trial-card:hover {
    border-color: #2A6E7B; /* Primary Teal */
    transform: translateY(-2px);
    box-shadow: 0 4px 12px rgba(42, 110, 123, 0.1);
}

.trial-header {
    display: flex;
    justify-content: space-between;
    align-items: flex-start;
    margin-bottom: 12px;
    gap: 16px;
}

.trial-title {
    font-size: 16px;
    font-weight: 600;
    color: #0F4A46; /* Dark Teal */
    flex: 1;
    line-height: 1.4;
}

.trial-badges {
    display: flex;
    gap: 8px;
    flex-shrink: 0;
}

.trial-badge {
    padding: 4px 8px;
    border-radius: 12px;
    font-size: 12px;
    font-weight: 600;
}

.trial-badge.phase {
    background: #2A6E7B; /* Primary Teal */
    color: #ffffff;
}

.trial-badge.status.recruiting {
    background: #22c55e;
    color: #ffffff;
}

.trial-badge.status.active {
    background: #f59e0b;
    color: #ffffff;
}

.trial-description {
    color: #335A57; /* Muted Text */
    margin-bottom: 12px;
    font-size: 14px;
    line-height: 1.5;
}

.trial-details {
    display: grid;
    grid-template-columns: repeat(auto-fit, minmax(150px, 1fr));
    gap: 12px;
    font-size: 14px;
}

.trial-detail {
    display: flex;
    flex-direction: column;
    gap: 4px;
}

.detail-label {
    color: #335A57; /* Muted Text */
    font-weight: 500;
}

.detail-value {
    color: #0F4A46; /* Dark Teal */
    font-weight: 600;
}

/* Diagnosis Section */
.diagnosis-result {
    display: flex;
    justify-content: space-between;
    align-items: center;
    margin-bottom: 16px;
    flex-wrap: wrap;
    gap: 16px;
}

.diagnosis-status,
.confidence-display {
    display: flex;
    align-items: center;
    gap: 8px;
}

.status-label,
.confidence-label {
    color: #335A57; /* Muted Text */
    font-weight: 500;
}

.status-value {
    font-weight: 700;
    font-size: 18px;
}

.status-value.positive {
    color: #dc2626;
}

.status-value.negative {
    color: #22c55e;
}

.confidence-value {
    font-weight: 700;
    font-size: 18px;
    color: #22c55e;
}

.diagnosis-explanation,
.chemo-explanation {
    color: #335A57; /* Muted Text */
    line-height: 1.6;
    font-size: 14px;
}

/* Chemo Response Section */
.chemo-result {
    margin-bottom: 16px;
}

.response-status {
    display: flex;
    align-items: center;
    gap: 8px;
}

.response-value {
    font-weight: 700;
    font-size: 18px;
}

.response-value.likely {
    color: #22c55e;
}

.response-value.unlikely {
    color: #dc2626;
}

/* Clinical Trials Section */
.trial-filters {
    display: flex;
    flex-direction: column;
    gap: 12px;
    margin-bottom: 24px;
}

.filter-group {
    display: flex;
    gap: 8px;
    flex-wrap: wrap;
}

.filter-chip {
    padding: 8px 16px;
    border: 1px solid #D9E6DF; /* Border/Divider */
    background: #ffffff;
    color: #335A57; /* Muted Text */
    border-radius: 20px;
    font-size: 14px;
    cursor: pointer;
    transition: all 0.3s ease;
}

.filter-chip:hover {
    border-color: #3b82f6;
    color: #1e293b;
}

.filter-chip.active {
    background: #3b82f6;
    color: #ffffff;
    border-color: #3b82f6;
}

.trials-list {
    display: flex;
    flex-direction: column;
    gap: 20px;
}

.trial-card {
    background: #f8fafc;
    border: 1px solid #e2e8f0;
    border-radius: 8px;
    padding: 20px;
    transition: all 0.3s ease;
}

.trial-card:hover {
    border-color: #3b82f6;
    transform: translateY(-2px);
}

.trial-header {
    display: flex;
    justify-content: space-between;
    align-items: flex-start;
    margin-bottom: 12px;
    gap: 16px;
}

.trial-title {
    font-size: 16px;
    font-weight: 600;
    color: #1e293b;
    flex: 1;
}

.trial-badges {
    display: flex;
    gap: 8px;
    flex-shrink: 0;
}

.trial-badge {
    padding: 4px 8px;
    border-radius: 12px;
    font-size: 12px;
    font-weight: 600;
}

.trial-badge.phase {
    background: #2A6E7B; /* Primary Teal */
    color: #ffffff;
}

.trial-badge.status.recruiting {
    background: #22c55e;
    color: #ffffff;
}

.trial-badge.status.active {
    background: #f59e0b;
    color: #ffffff;
}

.trial-description {
    color: #335A57; /* Muted Text */
    margin-bottom: 12px;
    font-size: 14px;
    line-height: 1.5;
}

.trial-details {
    display: grid;
    grid-template-columns: repeat(auto-fit, minmax(150px, 1fr));
    gap: 12px;
    font-size: 14px;
}

.trial-detail {
    display: flex;
    flex-direction: column;
    gap: 4px;
}

.detail-label {
    color: #335A57; /* Muted Text */
    font-weight: 500;
}

.detail-value {
    color: #1e293b;
    font-weight: 600;
}

/* ===== RESPONSIVE DESIGN ===== */

@media (max-width: 1200px) {
    .results-grid {
        gap: 32px;
    }
    
    .hero-title {
        font-size: 3rem;
    }
    
    .process-strip {
        flex-direction: column;
        gap: 16px;
        padding: 20px 24px;
    }
    
    .process-arrow {
        transform: rotate(90deg);
        margin: 8px 0;
    }
}

@media (max-width: 1024px) {
    .results-grid {
        grid-template-columns: 1fr;
        gap: 32px;
    }
    
    .results-header {
        flex-direction: column;
        align-items: flex-start;
        gap: 20px;
    }
    
    .action-buttons {
        width: 100%;
        justify-content: flex-start;
    }
    
    .hero-title {
        font-size: 2.5rem;
    }
    
    .hero-subtitle {
        font-size: 1.1rem;
    }
}

@media (max-width: 768px) {
    .analyzer-hero {
        padding: 60px 0;
    }
    
    .hero-title {
        font-size: 2.2rem;
    }
    
    .hero-subtitle {
        font-size: 1rem;
    }
    
    .process-strip {
        padding: 16px 20px;
    }
    
    .process-step {
        flex-direction: column;
        text-align: center;
        gap: 8px;
    }
    
    .step-icon {
        width: 40px;
        height: 40px;
        font-size: 20px;
    }
    
    .upload-zone {
        padding: 60px 30px;
    }
    
    .upload-title {
        font-size: 24px;
    }
    
    .results-title {
        font-size: 28px;
    }
    
    .action-buttons {
        flex-direction: column;
        width: 100%;
    }
    
    .action-buttons .btn {
        width: 100%;
        justify-content: center;
    }
    
    .image-header {
        flex-direction: column;
        align-items: flex-start;
        gap: 16px;
    }
    
    .image-actions {
        width: 100%;
        justify-content: flex-start;
    }
    
    .image-info {
        grid-template-columns: 1fr;
        gap: 12px;
    }
    
    .diagnosis-item,
    .chemo-item {
        flex-direction: column;
        align-items: flex-start;
        gap: 8px;
    }
    
    .trial-header {
        flex-direction: column;
        align-items: flex-start;
        gap: 12px;
    }
    
    .trial-badges {
        width: 100%;
        justify-content: flex-start;
    }
    
    .filter-group {
        flex-direction: column;
        align-items: flex-start;
        gap: 8px;
    }
    
    .filter-chips {
        width: 100%;
        justify-content: flex-start;
    }
    
    .trial-details {
        grid-template-columns: 1fr;
        gap: 8px;
    }
}

@media (max-width: 480px) {
    .analyzer-hero {
        padding: 40px 0;
    }
    
    .hero-title {
        font-size: 1.8rem;
    }
    
    .hero-subtitle {
        font-size: 0.9rem;
    }
    
    .process-strip {
        padding: 12px 16px;
    }
    
    .step-icon {
        width: 36px;
        height: 36px;
        font-size: 18px;
    }
    
    .upload-zone {
        padding: 40px 20px;
    }
    
    .upload-title {
        font-size: 20px;
    }
    
    .upload-subtitle {
        font-size: 14px;
    }
    
    .preview-card {
        padding: 16px;
        flex-direction: column;
        text-align: center;
        gap: 12px;
    }
    
    .preview-details {
        text-align: center;
    }
    
    .file-meta {
        flex-direction: column;
        gap: 4px;
    }
    
    .results-title {
        font-size: 24px;
    }
    
    .results-subtitle {
        font-size: 14px;
    }
    
    .card-header {
        flex-direction: column;
        align-items: flex-start;
        gap: 12px;
    }
    
    .card-content {
        padding: 0 16px 16px 16px;
    }
    
    .image-container {
        margin: 0 16px 16px 16px;
    }
    
    .image-info {
        padding: 0 16px 16px 16px;
    }
    
    .control-card {
        padding: 16px;
    }
    
    .slider-container {
        flex-direction: column;
        align-items: flex-start;
        gap: 8px;
    }
    
    #opacitySlider {
        width: 100%;
    }
    
    .trial-card {
        padding: 16px;
    }
}

/* ===== ACCESSIBILITY ===== */

/* Focus styles */
.upload-zone:focus,
.image-action:focus,
.filter-chip:focus,
.btn:focus {
    outline: 2px solid #3b82f6;
    outline-offset: 2px;
}

/* High contrast mode support */
@media (prefers-contrast: high) {
    .upload-zone {
        border-width: 4px;
    }
    
    .result-card {
        border-width: 2px;
    }
    
    .trial-card {
        border-width: 2px;
    }
}

/* Reduced motion support */
@media (prefers-reduced-motion: reduce) {
    .upload-zone,
    .result-card,
    .trial-card,
    .image-action,
    .filter-chip,
    .btn {
        transition: none;
    }
    
    .spinner-ring {
        animation: none;
    }
    
    .step-circle {
        animation: none;
    }
    
    .progress-fill {
        transition: none;
    }
}

/* Print styles */
@media print {
    .action-buttons,
    .image-actions,
    .heatmap-controls {
        display: none;
    }
    
    .results-grid {
        grid-template-columns: 1fr;
    }
    
    .result-card {
        break-inside: avoid;
        box-shadow: none;
        border: 1px solid #000;
    }
}