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| <p><strong>Mobile DNA in obligate intracellular bacteria</strong></p> | |
| <p>Seth Bordenstein</p> | |
| <p><em>Josephine Bay Paul Center for Comparative Molecular Biology and Evolution</em></p> | |
| <p><em>The Marine Biological Laboratory</em></p> | |
| <p><em>7 MBL Street, Woods Hole, MA 02543</em></p> | |
| <p><em>United States of American</em></p> | |
| <p>HYPERLINK "mailto:youremailaccount@xxx.xxx.xx" sbordenstein@mbl.edu </p> | |
| <p>The smallest bacterial genomes (less than 2Mb) are typically devoid of mobile DNA owing to their intracellular lifestyle and elevated rates of nucleotide deletion. Such streamlined genomes represent the few cases in which mobile DNA is absent from Life. The recent genome sequencing efforts of the most widespread invertebrate symbiont on the planet (<em>Wolbachia</em>) has revealed a surprising mobile DNA content of over 10%. Here I review the mobile DNA composition of intracellular bacteria and discuss our recent investigations into the molecular evolution and effects of bacteriophage in the evolutionary important <em>Wolbachia</em>. Among other findings, I describe the first evidence for recent lateral phage transfer among a consortium of obligate intracellular bacteria. </p> | |
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