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+ ---
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+ license: other
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+ tags:
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+ - gwas
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+ - polygenic-risk-score
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+ - psychiatric-genetics
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+ - pgc
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+ ---
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+
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+ # Substance Use Disorders GWAS Summary Statistics (PGC)
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+
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+ Mirror of Psychiatric Genomics Consortium (PGC) summary statistics for
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+ **Substance Use Disorders** (SUD2023), redistributed in a single Apache Parquet file
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+ for use with [OpenMed Genomics](https://huggingface.co/spaces/turmex2/openneuro-genomics).
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+
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+ ## Source
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+
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+ - **Primary citation:** Hatoum et al., Nature Mental Health 2023
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+ - **Original distributor:** Psychiatric Genomics Consortium
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+ (<https://pgc.unc.edu/for-researchers/download-results/>)
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+
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+ This mirror exists only because the upstream OpenMed mirror became
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+ inaccessible. No modifications have been made to the underlying data;
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+ per-shard parquet files were concatenated into a single file for
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+ convenient streaming.
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+
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+ ## File
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+
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+ `pgc-substance-use_SUD2023.parquet` -- one Apache Parquet file containing the full summary
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+ statistics table in the PGC's published schema (SNP, CHR, BP, A1, A2,
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+ FRQ, OR/BETA, SE, P, ...).
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+
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+ ## Usage
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+
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+ ```python
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+ import polars as pl
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+ df = pl.read_parquet(
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+ "https://huggingface.co/datasets/turmex2/pgc-substance-use/resolve/main/pgc-substance-use_SUD2023.parquet"
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+ )
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+ ```
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+
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+ ## License & terms of use
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+
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+ PGC summary statistics are released for non-commercial research use only.
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+ Do not attempt to re-identify individuals. Results derived from these
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+ data are **not** a clinical diagnosis. See the original publication for
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+ the full data-use agreement.