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### Instruction:
Does transcranial direct current stimulation of the motor cortex induce distinct changes in thermal and mechanical sensory percepts?
### Response:
| Cathodal tDCS temporarily reduced the sensitivity to A-fiber mediated somatosensory inputs. |
### Instruction:
Does disruption of periodontal integrity induce expression of apin by epithelial cell rests of Malassez?
### Response:
| The expression of APIN at an early time-point following disruption of periodontal integrity suggests that this protein may be part of the cascade of events leading to the activation of ERM during periodontal healing and regeneration. |
### Instruction:
Does anti-phosphorylcholine-opsonized low-density lipoprotein promote rapid production of proinflammatory cytokines by dendritic cells and natural killer cells?
### Response:
| Minimally modified LDL-stimulated DCs and NK cells were mutually stimulatory, with DC IL-12p70 needed by NK cells and with NK cell IFN-γ needed by DCs. Moreover, production of these proinflammatory cytokines was markedly enhanced when LDL was opsonized by anti-PC. In short, the data suggest that the elevated anti-PC levels in periodontitis patients could promote a mechanism that facilitates atherosclerosis. |
### Instruction:
Does knockdown of Cyclophilin D Gene by RNAi protect Rat from Ischemia/ Reperfusion-Induced Renal Injury?
### Response:
| Our study provides the evidence that CypD may be a potential target for protecting I/R-induced renal injury. |
### Instruction:
Does peer substance involvement modify genetic influences on regular substance involvement in young women?
### Response:
| While young women may select peers based on certain dispositional traits (e.g. permissiveness towards substance use), the social milieu constructed by PSI does modify the architecture of increased RSI in those individuals with increasing levels of PSI being associated with stronger expression of heritable influences. |
### Instruction:
Does coadministration of carvedilol attenuate nitrate tolerance by preventing cytochrome p450 depletion?
### Response:
| Coadministration of carvedilol attenuates nitrate tolerance through maintenance of NO/cGMP pathway activity by preventing free radical generation and CYP depletion. |
### Instruction:
Is deficiency in mouse Y chromosome long arm gene complement associated with sperm DNA damage?
### Response:
| This study provides the first evidence of DNA damage in sperm from mice with NPYq deficiencies and indicates that NPYq-encoded gene/s may play a role in processes regulating chromatin remodeling and thus in maintaining DNA integrity in sperm. |
### Instruction:
Is alternative splicing frequent during early embryonic development in mouse?
### Response:
| We propose that alternative splicing is an important developmental regulatory mechanism. We further propose that gene expression should routinely be monitored at both the whole transcript and the isoform level in developmental studies. |
### Instruction:
Do detection and analysis of alternative splicing in Yarrowia lipolytica reveal structural constraints facilitating nonsense-mediated decay of intron-retaining transcripts?
### Response:
| Y. lipolytica is the hemiascomycete with the most intron-rich genome sequenced to date, and it has several unusual genes with large introns or alternative transcription start sites, or introns in the 5' UTR. Our results suggest Y. lipolytica intron structure is subject to significant constraints, leading to the under-representation of stop-free introns. Consequently, intron-containing transcripts are degraded by a functional NMD pathway. |
### Instruction:
Does ghrelin receptor antagonism decrease alcohol consumption and activation of perioculomotor urocortin-containing neurons?
### Response:
| These findings indicate that the action of ghrelin on the regulation of alcohol consumption may occur via the pIIIu. |
### Instruction:
Do cancer incidence among women flax textile manufacturing workers in Lithuania?
### Response:
| The overall cancer and non-melanoma skin cancer incidence rate among flax spinning-weaving workers was lower compared with the Lithuanian population. The present findings lend some support to an excess of thyroid and nervous system cancers among dyeing-finishing workers and of oral cavity and pharynx cancer in spinning-weaving workers. |
### Instruction:
Does activation of Rac1 promote hedgehog-mediated acquisition of the myofibroblastic phenotype in rat and human hepatic stellate cells?
### Response:
| These findings demonstrate that interactions between Rac1 and the Hh pathway control the size of MF-HSC populations and have important implications for the pathogenesis of cirrhosis. |
### Instruction:
Are macroautophagy and chaperone-mediated autophagy required for hepatocyte resistance to oxidant stress?
### Response:
| Hepatocyte resistance to injury from menadione-induced oxidative stress is mediated by distinct functions of both macroautophagy and CMA, indicating that impaired function of either form of autophagy may promote oxidant-induced liver injury. |
### Instruction:
Does aquaporin-1 facilitate angiogenic invasion in the pathological neovasculature that accompanies cirrhosis?
### Response:
| AQP-1 enhances osmotic water permeability and FGF-induced dynamic membrane blebbing in LEC and thereby drives invasion and pathological angiogenesis during cirrhosis. |
### Instruction:
Does hepatitis B virus X protein blunt senescence-like growth arrest of human hepatocellular carcinoma by reducing Notch1 cleavage?
### Response:
| Our results reveal a novel function of HBx in blunting senescence-like growth arrest by decreasing Notch1 signaling, which could be a putative molecular mechanism mediating HBV-associated hepatocarcinogenesis. |
### Instruction:
Does mouse lung contain endothelial progenitors with high capacity to form blood and lymphatic vessels?
### Response:
| The lung contains large numbers of EPCs that display commitment for both types of vessels, suggesting that lung blood and lymphatic endothelial cells are derived from a single progenitor cell. |
### Instruction:
Is leukocyte telomere length associated with disability in older u.s. Population?
### Response:
| These findings support the concept that LTL is a biomarker of overall well-being that is predictive of disability of older individuals in the U.S. population. Diabetes mellitus plays an important role as a modifier of the association between LTL and disability, CVD, and cancer. These associations have clinical implications because of the potential predictive value of LTL and deserve further investigation. |
### Instruction:
Are th17 central memory T cells reduced by FTY720 in patients with multiple sclerosis?
### Response:
| Phenotypic Th17 cells are defined by a central memory T-cell phenotype. FTY720 reduces these Th17 cells in blood. This is presumably because central memory T cells are retained by FTY720 in secondary lymphoid organs. |
### Instruction:
Does empirical assessment suggest that existing evidence could be used more fully in designing randomized controlled trials?
### Response:
| Consulting previous research before embarking on a new trial and basing decisions about future research on the impact on an updated meta-analysis will make the reporting of research more coherent and the design of new RCTs more efficient. |
### Instruction:
Does intermittent ischaemia maintain function after ischaemia reperfusion in steatotic livers?
### Response:
| INT is more effective than IPC in restoring liver function in the acute phase of IR in steatotic livers. In obese patients, INT may be useful in promoting better liver function after IR after liver resection. |
### Instruction:
Do trajectories of antisocial behaviour towards siblings predict antisocial behaviour towards peers?
### Response:
| These findings highlight the importance of a developmental perspective when examining antisocial behaviour between young siblings. |
### Instruction:
Do different levels of overnutrition and weight gain during pregnancy have differential effects on fetal growth and organ development?
### Response:
| These data demonstrate that different levels of overfeeding, resulting in differing levels of maternal weight gain and adiposity prior to and during pregnancy, lead to differential effects on fetal overgrowth and organ development. |
### Instruction:
Does murine cytomegalovirus infection lead to increased levels of transplant arteriosclerosis in a murine aortic allograft model?
### Response:
| These data suggest that MCMV infection plays an important role in the development of transplant arteriosclerosis. |
### Instruction:
Do higher plant calreticulins have acquired specialized functions in Arabidopsis?
### Response:
| We conclude that the physiological functions of the two CRT subgroups in Arabidopsis have diverged, resulting in a role for AtCRT3 in PAMP associated responses, and possibly more general chaperone functions for AtCRT1a and CRT1b. |
### Instruction:
Do two-dimensional and Doppler echocardiography reliably predict severe pulmonary regurgitation as quantified by cardiac magnetic resonance?
### Response:
| Two-dimensional and Doppler echocardiography reliably identified severe PR in this cohort. |
### Instruction:
Does upper alpha activity during working memory processing reflect abnormal inhibition in major depression?
### Response:
| The results are consistent with increased inhibition of extraneous material during WM processing in depression. This may reflect a neurobiological compensation strategy whereby additional neural resources are required to achieve comparable performance accuracy during effortful cognitive processing in MDD. |
### Instruction:
Is variation in the vitamin D receptor gene associated with risk of colorectal cancer in the Czech Republic?
### Response:
| We conclude that common variation in the VDR gene had little effect on its own on predisposition to sporadic CRC in the Czech population. |
### Instruction:
Is the finding of premalignant lesions associated with smoking cessation in chemoprevention study volunteers?
### Response:
| A smoking cessation rate of 20% has been found among volunteers for a chemopreventive trial investigating smoking-related premalignant lesions after almost 2 years after initial contact has been found. Volunteers experienced screening and trial participation as having influenced their smoking cessation. Smoking cessation was significantly associated with male gender, whereas the finding of premalignant lesions by bronchoscopy was not. |
### Instruction:
Does treatment with triamcinolone acetonide prevent decreased retinal levels of decorin in a rat model of oxygen-induced retinopathy?
### Response:
| Our results suggest that decorin is involved in hypoxic retinal damage and that TA protects retinal neurons damaged by relative hypoxia from decreased decorin levels. |
### Instruction:
Are stem cell-derived neurons grafted in the striatum expelled out of the brain after chronic cortical stroke?
### Response:
| Stroke-related brain atrophy and reshaping were not prevented by cell grafting and, eventually, led to the expulsion of the graft. |
### Instruction:
Is impaired cerebrovascular reactivity with steal phenomenon associated with increased diffusion in white matter of patients with Moyamoya disease?
### Response:
| Regions of steal phenomenon are spatially correlated with elevated ADC in normal-appearing WM of patients with Moyamoya disease. This structural abnormality may reflect low-grade ischemic injury after exhaustion of the cerebrovascular reserve capacity. |
### Instruction:
Does synergistic activation of phospholipase C-beta3 by Galpha ( q ) and Gbetagamma describe a simple two-state coincidence detector?
### Response:
| Synergism can be explained by a simple and general mechanism, and such a mechanism sets parameters for its occurrence. Any two-state enzyme is predicted to respond synergistically to multiple activating ligands if, but only if, its basal activity is strongly suppressed. |
### Instruction:
Do h1-receptor antagonists terfenadine and loratadine inhibit spontaneous growth of neoplastic mast cells?
### Response:
| The HR1 antagonists terfenadine and loratadine, in addition to their antimediator activity, exert in vitro growth-inhibitory effects on neoplastic MCs. Whether these drugs (terfenadine) alone, or in combination with KIT inhibitors, can also affect in vivo neoplastic MC growth remains to be determined. |
### Instruction:
Does neuronal nitric oxide synthase protect the pancreatic beta cell from glucolipotoxicity-induced endoplasmic reticulum stress and apoptosis?
### Response:
| In beta cells subjected to glucolipotoxic conditions, chronic inhibition of NOS exacerbates ER stress and activates JNK. Therefore, induction of nNOS is an adaptive response to glucolipotoxicity that protects beta cells from stress and apoptosis. |
### Instruction:
Does species-specific differential AhR expression protect human neural progenitor cells against developmental neurotoxicity of PAHs?
### Response:
| Our findings suggest that in contrast to wild-type mNPCs, hNPCs were protected against polycyclic aromatic hydrocarbon-induced DNT because of an absence of AhR This difference may contribute to species-specific differences in sensitivity to POPs. |
### Instruction:
Does imatinib mesylate enhance the malignant behavior of human breast carcinoma cells?
### Response:
| Our data suggest caution in the clinical use of Imatinib in breast cancer patients; the comparison of Imatinib-surviving breast cancer cells with parental cells may help define the regulatory pathways involved in the increased malignancy of residual tumor cells that survive therapy, ultimately providing important therapeutic targets. |
### Instruction:
Does short-term femoral vein catheterization rarely cause thrombosis or bacteremia?
### Response:
| Short-term FVC was used safely in our MICU in the setting of thromboprophylaxis. In light of its favorable safety profile for initial resuscitation of critically ill patients, it may be premature to strongly discourage FVC. |
### Instruction:
Are fibroblast growth factor 23 and fetuin A independent predictors for the coronary artery disease extent in mild chronic kidney disease?
### Response:
| This study suggests that in a relatively young population with mild-to-moderate alteration of kidney function and with less traditional cardiovascular risk factors, anomalies of the serum FGF 23 and fetuin A levels appear early in the course of disease and are independent major predictors for extent of CAD. |
### Instruction:
Does tranexamic acid reduce allogenic transfusion in revision hip arthroplasty?
### Response:
| To further increase the relevance of the blood utilization program, the guidelines for patients undergoing revision hip arthroplasty need to be redefined. |
### Instruction:
Does antagomir dependent microRNA-205 reduction enhance adhesion ability of human corneal epithelial keratinocytes?
### Response:
| Our findings suggest that microRNA-205 has down-regulating effect on cell motility in NHCEKs. |
### Instruction:
Does left atrial volume predict mortality in low-risk dialysis population on long-term low-salt diet?
### Response:
| Increased LA volume index emerged as the only independent echocardiographic determinant of mortality in low-risk dialysis patients treated by strict volume control. Close relationship with IDWG ratio indicates the intermittent stretching of atrium between dialysis sessions leading to atrial remodeling. This index is not the result of a single factor such as age, hypervolemia, or left ventricular hypertrophy but reflects the combination of these contributing causes. Therefore, it might be considered as an overall echocardiographic sign of mortality in ESRD. |
### Instruction:
Does normal intima-media thickness on carotid ultrasound reliably exclude an ischemic cause of cardiomyopathy?
### Response:
| Carotid ultrasound with IMT measurement is a valuable screening tool for excluding an ischemic etiology of LVSD when CAD is suspected. |
### Instruction:
Is central aortic pressure independently associated with diastolic function?
### Response:
| The nonpulsatile components of aortic afterload (cMAP and cDBP) exhibited a weak but significant association with LV relaxation, whereas the pulsatile component of afterload, cPP, exhibited strong association with LV filling pressure. |
### Instruction:
Does exposure error mask the relationship between traffic-related air pollution and heart rate variability?
### Response:
| Results indicate decreased vagal tone in response to traffic pollutants, which can best be detected with precise personal exposure measures. |
### Instruction:
Are plasma adiponectin levels related to obesity , inflammation , blood lipids and insulin in type 2 diabetic and non-diabetic Trinidadians?
### Response:
| Adiponectin decreases with increasing adiposity and insulin resistance. Adiponectin and TNF-α appear to be related to differences in the insulin mediated glucose turnover. |
### Instruction:
Is preoperative clinically inapparent leucopenia in patients undergoing neoadjuvant chemotherapy for locally advanced gastric cancer a risk factor for surgical or general postoperative complications?
### Response:
| Conclusively patients with clinically inapparent leucopenia after neoadjuvant chemotherapy due to advanced stage gastric cancer can be safely operated on without putting them in danger of relevant surgical complications. |
### Instruction:
Are high pretherapeutic thymidylate synthetase and MRP-1 protein levels associated with nonresponse to neoadjuvant chemotherapy in oesophageal adenocarcinoma patients?
### Response:
| The pattern of pretherapeutic expression of TS and MRP-1 is related to chemotherapy response in oesophageal adenocarcinoma patients. Immunohistochemical assessment of these markers may be helpful for response prediction. |
### Instruction:
Does continuous positive airway pressure therapy improve arterial elasticity in patients with obstructive sleep apnea?
### Response:
| Six months of CPAP therapy improves arterial elasticity in subjects with OSA. |
### Instruction:
Does sTAT3 regulate acute liver injury after ischemia/reperfusion?
### Response:
| The data suggest that STAT3 is not a central regulator of acute liver injury induced by I/R. |
### Instruction:
Does fresh frozen plasma increase adhesion molecule expression on human pulmonary endothelial cells?
### Response:
| FFP at both ages significantly increased expression of four different adhesion molecules compared with LR in PECs. This may represent a possible mechanism for increased leukocyte binding on the endothelium as a result of FFP transfusion. |
### Instruction:
Is mortality reduced for heart rate 80 to 89 after traumatic brain injury?
### Response:
| After isolated moderate to severe TBI, HR <50, 50-59, 60-69, and > or =110 were independent predictors of increased mortality. HR outside the range 70-109 could serve as a marker for aggressive resuscitation. As mortality increased significantly with HR: <50 (AOR 4.70), 50-59 (AOR 2.21), and 60-69 (AOR 1.63), our findings recommend avoiding HR < 70 in patients with moderate to severe TBI. |
### Instruction:
Is the common rs9939609 variant of the fat mass and obesity-associated gene associated with obesity risk in children and adolescents of Beijing , China?
### Response:
| The FTO rs9939609 variant is strongly associated with BMI and the risk of obesity in a population of children and adolescents in Beijing, China. |
### Instruction:
Does overexpression of candidate tumor suppressor ECRG4 inhibit glioma proliferation and invasion?
### Response:
| Our data suggest that ECRG4 serves as a tumor suppressor in glioma. |
### Instruction:
Is serum oxidative stress increased in patients with post cholecystectomy bile duct injury?
### Response:
| The results show that oxidative stress is usually associated to bile duct injury. |
### Instruction:
Does anti-centromere antibody-seropositive Sjögren 's syndrome differ from conventional subgroup in clinical and pathological study?
### Response:
| Low cellular infiltration but with an increase in fibrous tissues may explain the clinical feature of a high prevalence of RP and normal IgG concentration in ACA+ pSS. |
### Instruction:
Do [ Study on the chemical constituents from pine needles of Cedrus deodara ]?
### Response:
| Compounds I-IV, VI-VIII are isolated and identified from this genus for the first time, compound V is isolated from pine needles of this genus for the first time. |
### Instruction:
Does micro-RNA-181a regulate osteopontin-dependent metastatic function in hepatocellular cancer cell lines?
### Response:
| MiRNA 181a decreases OPN expression in HCC cell lines. This previously undescribed mechanism may confer metastatic characteristics to HCC. |
### Instruction:
Does herpes simplex virus induce neural oxidative damage via microglial cell Toll-like receptor-2?
### Response:
| These studies demonstrate the importance of microglial cell TLR2 in inducing oxidative stress and neuronal damage in response to viral infection. |
### Instruction:
Does elevated MED28 expression predict poor outcome in women with breast cancer?
### Response:
| We have demonstrated that MED28 expression is increased in breast cancer. In addition, although the patient size was limited (88 individuals with survival information) MED28 is a novel and strong independent prognostic indicator of survival for breast cancer. |
### Instruction:
Does diagnosing placental membrane hypoxic lesions increase the sensitivity of placental examination?
### Response:
| Recognizing placental membrane hypoxic lesions increases the sensitivity of placental examination in diagnosing placental hypoxia by at least 15%. The risk of in utero hypoxia is increased when microscopic chorionic pseudocysts and laminar necrosis occur in conjunction with villous hypoxic lesions. |
### Instruction:
Do trypsin-like protease-active extracellular protein extracts from Porphyromonas gingivalis ATCC 33277 induce apoptosis in bovine aortic endothelial cells?
### Response:
| Trypsin-like protease-active protein extracts from P. gingivalis could induce apoptosis of BAECs. The destruction of alpha-tubulin and integrin beta1 and decrease of ERK1/2 activation might contribute to the pro-apoptotic effect of the protein extracts. |
### Instruction:
Are levels of specific immunoglobulin G to the forsythia detaching factor of Tannerella forsythia in gingival crevicular fluid related to the periodontal status?
### Response:
| These data suggest that anti-FDF IgG levels in gingival crevicular fluid are related to the periodontal status. |
### Instruction:
Is soluble P selectin in synovial fluid level correlated with the radiographic severity of knee osteoarthritis?
### Response:
| The Ps levels in SF were significantly correlated with the severity of OA, suggesting that it may be used as a biomarker to evaluate the progression of OA. |
### Instruction:
Does early alpha-fetoprotein response predict treatment efficacy of antiangiogenic systemic therapy in patients with advanced hepatocellular carcinoma?
### Response:
| The current results indicated that an early AFP response is a useful surrogate marker to predict treatment response and prognosis in patients with advanced HCC who receive antiangiogenic therapy. |
### Instruction:
Does milk fat globule EGF factor 8 attenuate sepsis-induced apoptosis and organ injury in alcohol-intoxicated rats?
### Response:
| rmMFG-E8 attenuates sepsis-induced apoptosis and organ injury in alcohol-intoxicated rats. |
### Instruction:
Does motivation for alcohol become resistant to quinine adulteration after 3 to 4 months of intermittent alcohol self-administration?
### Response:
| We have developed a novel and technically simple hybrid operant/IAA model in which quinine-resistant motivation for alcohol is evident after an experimentally tractable period of time (3 to 4 months vs. 8 months). Quinine dramatically reduced sucrose and water intake by IAA rats, indicating that continued responding for alcohol in IAA rats despite adulteration with the normally aversive quinine might reflect maladaptive or compulsive motivation for alcohol. This model could facilitate identification of novel therapeutic interventions for pathological alcohol seeking in humans. |
### Instruction:
Does ethanol alter cell fate of fetal human brain-derived stem and progenitor cells?
### Response:
| This study shows that ETOH alters the cell fate of neuronal stem and progenitor cells. These alterations could contribute to the mechanism for the abnormal brain development in FASD. |
### Instruction:
Does maternal glucose tolerance in pregnancy affect fetal insulin sensitivity?
### Response:
| Maternal glucose intolerance may impair fetal insulin sensitivity (but not beta-cell function) and consequently "program" the susceptibility to type 2 diabetes. |
### Instruction:
Does metabolic state alter economic decision making under risk in humans?
### Response:
| We show that human risk preferences are exquisitely sensitive to current metabolic state, in a direction consistent with ecological models of feeding behaviour but not predicted by normative economic theory. These substantive effects of state changes on economic decisions perhaps reflect shared evolutionarily conserved neurobiological mechanisms. We suggest that this sensitivity in human risk-preference to current metabolic state has significant implications for both real-world economic transactions and for aberrant decision-making in eating disorders and obesity. |
### Instruction:
Does activation of adenosine A2A receptors restore the altered cell-cycle machinery during impaired wound healing in genetically diabetic mice?
### Response:
| Our results suggest that adenosine A2(A) receptor activation by PDRN might represent a therapeutic strategy to overcome the diabetes-impaired cell-cycle machinery. |
### Instruction:
Does bid agonist regulate murine hepatocyte proliferation by controlling endoplasmic reticulum calcium homeostasis?
### Response:
| Bid regulates hepatocyte proliferation by positively affecting [Ca(2+)](ER) homeostasis, and this could be important for liver regeneration and carcinogenesis. |
### Instruction:
Is an in vitro-identified high-affinity nucleosome-positioning signal capable of transiently positioning a nucleosome in vivo?
### Response:
| These results demonstrate an ability of DNA sequences selected solely for nucleosome affinity to organize chromatin in vivo, and the ability of other mechanisms to overcome these interactions in a dynamic nuclear environment. |
### Instruction:
Is pTEN genomic deletion an early event associated with ERG gene rearrangements in prostate cancer?
### Response:
| We show significant association between ERG gene rearrangements and PTEN genomic aberrations in subset of PCA. Our analysis also provides further support for the observation that homozygous PTEN deletions can occur within the subset of HGPIN lesions, and shows accumulating genetic aberrations with disease progression, evidenced by higher detection in PCA than in HGPIN and more PTEN homozygous deletions in GS 8-10 than in 6-7. |
### Instruction:
Are vital signs and cognitive function affected by 23-sodium and 17-oxygen magnetic resonance imaging of the human brain at 9.4 T?
### Response:
| (23)Na and (17)O MRI of the human brain at 9.4 T does not have any readily demonstrated health risks reflected in vital signs or change in cognitive performance. |
### Instruction:
Is fracture risk in children with a forearm injury associated with volumetric bone density and cortical area ( by peripheral QCT ) and areal bone density ( by DXA )?
### Response:
| Low vBMD, aBMD, cortical area, and SSI of the distal radius were associated with an increased fracture risk. Interventions to increase these characteristics are needed to help reduce forearm fracture occurrence. |
### Instruction:
Are absence epilepsies with widely variable onset a key feature of familial GLUT1 deficiency?
### Response:
| GLUT1 deficiency is an important monogenic cause of absence epilepsies with onset from early childhood to adult life. Individual cases may be phenotypically indistinguishable from common forms of IGE. Although subtle paroxysmal exertional dyskinesia is a helpful diagnostic clue, it is far from universal. The phenotypic spectrum of GLUT1 deficiency is considerably greater than previously recognized. Diagnosis of GLUT1 deficiency has important treatment and genetic counseling implications. |
### Instruction:
Does concurrent helminthic infection protect schoolchildren with Plasmodium vivax from anemia?
### Response:
| For the first time, a cohort study showed that intestinal helminthes protect against hemoglobin decrease during an acute malarial attack by P. vivax. |
### Instruction:
Does a major histocompatibility Class I locus contribute to multiple sclerosis susceptibility independently from HLA-DRB1*15:01?
### Response:
| A MHC Class I locus contributes to MS susceptibility independently of the HLA-DRB1*15:01 haplotype. |
### Instruction:
Does carotid ultrasound identify high risk subclinical atherosclerosis in adults with low framingham risk scores?
### Response:
| Thirty-eight percent of asymptomatic young to middle-aged individuals with FRS < or = 5% have abnormal carotid ultrasound findings associated with increased risk for CV events. Pharmacologic therapy for CV prevention was recommended in the majority of these individuals. The lack of radiation exposure, relatively low cost, and ability to detect early-stage atherosclerosis suggest that carotid ultrasound for CIMT and plaque detection should continue to be explored as a primary tool for CV risk stratification in young to middle-aged adults with low FRS. |
### Instruction:
Does [ Short hairpin RNA targeting N-acetylglucosaminyltransferase V inhibit the proliferation of prostate cancer PC-3 cell line ]?
### Response:
| The shRNA targeting GnT-V gene can reduce the expression of GnT-V mRNA and inhibit the proliferation of PC-3 cells in vitro. |
### Instruction:
Do human bone marrow mesenchymal stem cells display anti-cancer activity in SCID mice bearing disseminated non-Hodgkin 's lymphoma xenografts?
### Response:
| Our data demonstrate that BM-MSC exhibit anti-lymphoma activity in two distinct xenograft SCID mouse models of disseminated NHL. |
### Instruction:
Does a multicomponent intervention reduce body weight and cardiovascular risk at a GEICO corporate site?
### Response:
| Among individuals volunteering for a 22-week worksite research study, an intervention using a low-fat, vegan diet effectively reduced body weight and waist circumference. |
### Instruction:
Does momordica charantia ( bitter melon ) inhibit primary human adipocyte differentiation by modulating adipogenic genes?
### Response:
| Our data suggests that BMJ is a potent inhibitor of lipogenesis and stimulator of lipolysis activity in human adipocytes. BMJ may therefore prove to be an effective complementary or alternative therapy to reduce adipogenesis in humans. |
### Instruction:
Is educational level a crucial factor for good perceived health in the local community?
### Response:
| Public health in local communities tends to reflect the social history and social heritage of the population. In this study, we found that educational level appears to be a vital factor for good perceived health of the individual in a community. |
### Instruction:
Is visual guidance of interceptive actions in children with spastic unilateral cerebral palsy influenced by the side of the lesion?
### Response:
| The side of the lesion influences the visual information used to initiate interceptive actions. |
### Instruction:
Do dynamic changes in gene expression in vivo predict prognosis of tamoxifen-treated patients with breast cancer?
### Response:
| Both early/transient/proliferation response genes and continuous/late/estrogen-response genes are able to predict prognosis of primary breast tumours in a dynamic manner. Temporal expression of therapy-response genes is clearly an important factor in characterising the response to endocrine therapy in breast tumours which has significant implications for the timing of biopsies in neoadjuvant biomarker studies. |
### Instruction:
Do somatic symptom overlap in Beck Depression Inventory-II scores following myocardial infarction?
### Response:
| Our findings contradict assertions that self-report depressive symptom measures inflate severity scores in post-AMI patients. However, the preponderance of somatic symptoms at low score levels across groups suggests that BDI-II scores may include a small amount of somatic symptom variance not necessarily related to depression in post-AMI and non-medically ill respondents. |
### Instruction:
Do serum soluble tumour necrosis factor receptor type I concentrations independently predict prognosis in patients with breast cancer?
### Response:
| Serum sTNF RI may be considered an additional, independent and clinically useful factor of poor prognosis in patients with breast cancer. |
### Instruction:
Is pain in ehlers-danlos syndrome common , severe , and associated with functional impairment?
### Response:
| From this large cohort of EDS patients, we conclude that pain is common and severe in EDS. Pain is related to hypermobility, dislocations, and previous surgery and associated with moderate to severe impairment in daily functioning. Therefore, treatment of pain should be a prominent aspect of symptomatic management of EDS. |
### Instruction:
Does first trimester histiotrophe show altered sialylation compared with secretory phase glycoconjugates in human endometrium?
### Response:
| Suppression of terminal sialylation is evident during early pregnancy, suggesting that modifications to endometrial glandular activity occur in response to placental signals. The changes may facilitate absorption of histiotrophe by the trophoblast and enhance availability of substrates for degradation. |
### Instruction:
Is ultrasound-assessed perirenal fat related to increased ophthalmic artery resistance index in HIV-1 patients?
### Response:
| Our data indicate that ultrasound assessment of PRFT may have potential as a marker of increased endothelial damage with specific involvement of the ocular vascular region in HIV-1-infected patients. |
### Instruction:
Is the Runx transcriptional co-activator , CBFbeta , essential for invasion of breast cancer cells?
### Response:
| CBFbeta is expressed in metastatic breast cancer cells and is essential for cell invasion. CBFbeta is required for expression of several Runx2-target genes known to be involved in cell invasion. However, whilst CBFbeta is essential for invasion, not all Runx2-target genes require CBFbeta. We conclude that CBFbeta is required for a subset of Runx2-target genes that are sufficient to maintain the invasive phenotype of the cells. These findings suggest that the interaction between Runx2 and CBFbeta might represent a viable target for therapeutic intervention to inhibit bone metastasis. |
### Instruction:
Does fetal-placental hypoxia result from failure of spiral arterial modification in mice?
### Response:
| In mice, lack of pregnancy-associated spiral artery remodeling does not impair oxygen delivery to the conceptus, challenging the concept that deficient spiral arterial remodeling leads to fetal hypoxia in human gestational complications such as preeclampsia and fetal growth restriction. The isolated hypoxic response of normal kidney has revealed that renal lymphocytes may have unique, tissue-specific regulatory actions on vasoconstriction that are pregnancy independent. |
### Instruction:
Does ezrin promote invasion and metastasis of pancreatic cancer cells?
### Response:
| We propose that ezrin might play functional roles in modulating morphology, growth, motility and invasion of pancreatic cancer cells, and that the Erk1/2 pathway may be involved in these roles. Moreover, ezrin may participate in the early events of PDAC development and may promote its progression to the advanced stage. |
### Instruction:
Does enteral nutrition decrease hospitalization rate in patients with Crohn 's disease?
### Response:
| The use of an elemental diet of 900 kcal/day may be effective in avoiding hospitalization in CD patients with ileal lesions. This diet may be useful in improving the long-term convalescence of these patients. |
### Instruction:
Does contributions of remote monitoring to the follow-up of implantable cardioverter-defibrillator lead under advisory?
### Response:
| Remote monitoring allowed the early and reliable detection of ICD leads failure without requiring any patient intervention. |
### Instruction:
Do sociodemographics and comorbidities influence decisions to undergo pancreatic resection for neoplastic lesions?
### Response:
| Patients with a higher ACCI and those from a NESB are less likely to undergo surgery for resectable neoplastic lesions of the pancreas. These factors must be taken into consideration in the decision-making process when considering surgery for patients with pancreatic neoplasms. Novel strategies should be employed to optimize access to surgery for patients with resectable pancreatic neoplasms. |
### Instruction:
Do amino acids change liver growth factors gene expression in malnourished rats?
### Response:
| Proline or glutamine supplementation in malnourished rats improves total RNA content in the remnant hepatic tissue. Amino acids administration increased HGF gene expression after partial hepatectomy in malnourished rats, with a greater effect of proline than glutamine. |
### Instruction:
Does serum Mac-2BP distinguish men with high grade , large volume prostate cancer from men with benign prostatic hyperplasia?
### Response:
| Serum Mac-2BP does not appear to originate in the prostate and it is unlikely that Mac-2BP can be used for the differential diagnosis of prostate cancer versus BPH. |
### Instruction:
Do psychoacoustic abilities associated with music perception in cochlear implant users?
### Response:
| This study suggests that spectral-ripple discrimination is significantly associated with music perception in CI users. A previous report showed that spectral-ripple discrimination is significantly correlated with speech recognition in quiet and in noise. This study also showed that speech recognition and music perception are also related to one another. Spectral-ripple discrimination ability seems to reflect a wide range of hearing abilities in CI users. The results suggest that materially improving spectral resolution could provide significant benefits in music and speech perception outcomes in CI users. |
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