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### Instruction: Do cOAGULATION FACTORS LEVEL IN FRESH FROZEN PLASMA IN RWANDA? ### Response:
There is good retention of all coagulation factors and inhibitors in plasma produced from whole blood within eight hours of collection, stored at minus 18 degrees C for three months.
### Instruction: Does a Single-Nucleotide Polymorphism of miR-196a2T > C rs11614913 be Associated with Hepatocellular Carcinoma in the Chinese Population? ### Response:
In this study, we found that the CT+CC genotypes of rs11614913 were significantly associated with an increased risk and poor prognosis for HCC in the Chinese population.
### Instruction: Do reconstruction of post burn scalp alopecia by using expanded hair-bearing scalp flaps? ### Response:
Tissue expansion is a simple, safe, & efficient technique for aesthetic scalp reconstruction. With a simple modification of distal incision and tunneling, we succeeded in minimizing complications. Versatile design of the expanded scalp flap can distribute the expanded hair-bearing scalp properly in the reconstructed recipient site.
### Instruction: Is down-Regulation of microRNA-132 Associated with Poor Prognosis of Colorectal Cancer? ### Response:
Down-regulation of miR-132 is associated with poor prognosis in CRC. ANO1 could be one of the crucial targets of miR-132 in CRC.
### Instruction: Is neck circumference associated with carotid intimal-media thickness but not with coronary artery calcium : Results from The ELSA-Brasil? ### Response:
Neck circumference was significantly and independently associated with cc-IMT but not with CAC in women and men, indicating a possible effect of perivascular fat tissue on atherosclerosis.
### Instruction: Does select Bcl-2 antagonism restore chemotherapy sensitivity in high-risk neuroblastoma? ### Response:
HR NB patients are often thrombocytopenic at relapse, raising concerns for therapies like ABT-263 despite its HR NB tumor targeting potential. Our data confirms that Bcl-2 selective inhibitors like ABT-199 are equally potent in HR NB in vitro and in vivo and given their lack of platelet toxicity, should be translated into the clinic for HR NB.
### Instruction: Does polymyxin B hemoperfusion prevent acute kidney injury in sepsis model? ### Response:
These findings suggest that PMX-DHP may protect against acute kidney injury not only by inhibiting the NF-κB signaling pathway but also by preventing renal tubular cell apoptosis.
### Instruction: Does sildenafil obviate ischemia-reperfusion injury-induced acute kidney injury through peroxisome proliferator-activated receptor γ agonism in rats? ### Response:
It is concluded that sildenafil protects against ischemia-reperfusion-induced AKI through PPAR-γ agonism in rats.
### Instruction: Does interleukin 6 production during cardiac surgery correlate with increasing age? ### Response:
These data suggest that patients aged >70 y undergoing cardiac operations generate more IL-6 during CPB. The increased circulating IL-6 in elderly patients may incite a proinflammatory state that could subsequently underlie the associated higher mortality and morbidity of these procedures in elderly patients.
### Instruction: Does chromogranin A predict survival for resected pancreatic neuroendocrine tumors? ### Response:
In patients with resected pNETs, an elevated preoperative CgA level was negatively associated with DFS and OS and was the only independent predictor of DFS. These results indicate that preoperative CgA may be a clinically useful prognostic marker for patients undergoing pancreatic neuroendocrine tumor resection.
### Instruction: Does c-Peptide be a Sensitive Indicator for the Diagnosis of Metabolic Syndrome in Subjects from Central Mexico? ### Response:
C-peptide is a strong indicator of MetS. Since C-peptide has recently emerged as a biomolecule with significant importance for inflammatory diseases, monitoring C-peptide levels will aid clinicians in preventing MetS.
### Instruction: Is spontaneous bacterial peritonitis a risk factor for renal failure requiring dialysis in waitlisted liver transplant candidates? ### Response:
Spontaneous bacteria peritonitis patients have a significantly increased likelihood to require dialysis and mean shorter waitlist time. Furthermore, the combined occurrence of SBP and dialysis is a strong risk factor for all-cause mortality while on the LT wait list.
### Instruction: Is ovarian kisspeptin expression related to age and to monocyte chemoattractant protein-1? ### Response:
These data suggest a possible age-related physiologic role for the kisspeptinergic system in ovarian physiology. Additionally, the inflammatory MCP-1 may be associated with kiss1 and AMH genes, which are important in ovulation and folliculogenesis, respectively.
### Instruction: Is lower leg muscle density independently associated with fall status in community-dwelling older adults? ### Response:
Muscle density was associated with fall status, independent of functional mobility. Muscle density may compliment functional mobility tests as a biometric outcome for assessing fall risk in well-functioning older adults.
### Instruction: Are guideline-concordant weight-loss programs in an urban area uncommon and difficult to identify through the internet? ### Response:
Most weight-loss programs in an urban, mid-Atlantic region do not currently offer guideline-concordant practices and fail to disclose key information online, which may make clinician referrals challenging.
### Instruction: Are video capsule endoscopy completion and total transit times similar with oral or endoscopic delivery? ### Response:
VCE completion rates and total transit times are similar after oral or endoscopic deployment for both hospitalized and ambulatory patients. Endoscopic placement is effective in patients with contraindications to standard oral ingestion, but should otherwise be avoided to limit unnecessary procedural risks and costs.
### Instruction: Are sT-segment abnormalities associated with long-term prognosis in non-ST-segment elevation acute coronary syndromes : The ERICO-ECG study? ### Response:
ST-segment abnormalities after the initial tracing added long-term prognostic information.
### Instruction: Are β-catenin and Kras/Foxm1 signaling pathway critical to restrict Sox9 in basal cells during pulmonary branching morphogenesis? ### Response:
Interactions between the Wnt/β-catenin and the Kras/ERK/Foxm1 pathways are essential to restrict SOX9 expression in basal cells. Developmental Dynamics 245:590-604, 2016. © 2016 Wiley Periodicals, Inc.
### Instruction: Do cervical cages placed bilaterally in the facet joints from a posterior approach significantly increase foraminal area? ### Response:
Implantation of bilateral posterior cervical cages can increase foraminal area and may indirectly decompress the nerve roots. Correlation between increase in foraminal area and clinical outcomes needs further investigation.
### Instruction: Does family need at a post-acute rehabilitation setting and suggestions for supports? ### Response:
Family members who do not provide daily care are still impacted by the neurobehavioural changes that progress throughout the long-term, post-acute community phase. This study offers suggestions regarding an effective methodology for assessing family needs and recommends accessible and practical supports.
### Instruction: Does progressive Coronary Dilatation predict Worse Outcome in Kawasaki Disease? ### Response:
In addition to coronary diameters 1 month after the onset of KD, progressive coronary dilatation at 2 or more months after diagnosis may be an indicator of duration, and the severity of vasculitis and adverse dilative remodeling were associated with worse late coronary outcomes.
### Instruction: Does underutilization of radiation therapy in early-stage marginal zone lymphoma negatively impact overall survival? ### Response:
Although clinical guidelines endorse radiation therapy as the preferred initial therapy for early-stage nongastric and Helicobacter pylori-negative gastric mucosa-associated lymphoid tissue lymphoma, radiation therapy is underused. Radiation therapy with or without systemic therapy was associated with a significant improvement in OS and should remain standard of care.
### Instruction: Does l-Citrulline Supplementation enhance Fetal Growth and Protein Synthesis in Rats with Intrauterine Growth Restriction? ### Response:
l-Citrulline increases fetal growth in a model of IUGR, and the effect may be mediated by enhanced fetal muscle protein synthesis and/or increased NO production.
### Instruction: Does l-Glutamine enhance Tight Junction Integrity by Activating CaMK Kinase 2-AMP-Activated Protein Kinase Signaling in Intestinal Porcine Epithelial Cells? ### Response:
Our findings indicate that activation of CaMKK2-AMPK signaling by Gln is associated with improved intestinal mucosal barrier function through enhancing the abundance of TJ proteins and altering their intracellular localization in intestinal porcine epithelial cells.
### Instruction: Does low 25-Hydroxyvitamin D Level be Associated with Peripheral Arterial Disease in Type 2 Diabetes Patients? ### Response:
Low serum 25(OH)D levels were significantly associated with a higher prevalence of PAD in type 2 diabetes patients <65 years of age. It may increase the risk of PAD independent of other known cardiovascular risk factors.
### Instruction: Are interleukin-1β gene variants associated with QTc interval prolongation following cardiac surgery : a prospective observational study? ### Response:
The results suggest a contribution of IL1β in modulating susceptibility to postoperative QTc prolongation after cardiac surgery.
### Instruction: Do extracellular vesicles participate in the transport of cytokines and angiogenic factors in diabetic patients with ocular complications? ### Response:
The profiles of cytokines and angiogenic factors in EVs are significantly increased in patients with diabetes. Also, the formation of specific cytokines related to EVs is strongly influenced by disease duration and successful treatment. EVs seem to be the conveyors of upregulated cytokines and angiogenic agents in diabetic patients.
### Instruction: Does blockade of cell adhesion molecules enhance cell engraftment in a murine model of liver cell transplantation? ### Response:
Modification of the vascular wall with monoclonal antibodies against endothelial adhesion molecules before cell transplantation enhances cell engraftment into the mouse liver.
### Instruction: Is p2X1-regulated IL-22 secretion by innate lymphoid cells required for efficient liver regeneration? ### Response:
This study shows that innate immune cell-derived IL-22 is required for efficient liver regeneration and that secretion of IL-22 in the regenerating liver is modulated by the ATP receptor, P2X1. (Hepatology 2016;63:2004-2017).
### Instruction: Is very early social support following mild stroke associated with emotional and behavioral outcomes three months later? ### Response:
Patient perceptions of better support quality, and not quantity, immediately following mild stroke, are associated with better behavioral and emotional outcomes three months later.
### Instruction: Is timing of allergen exposure and the development of food allergy : treating before the horse out of the barn? ### Response:
Recent studies suggest that early rather than late introduction of allergenic foods reduces the risk of food allergy. The preferred timing of food introduction might be sooner than the current recommendation, and might apply not only to high-risk infants.
### Instruction: Do [ BONE TRANSPORTATION BY RING TYPE EXTERNAL FIXATOR COMBINED WITH LOCKED INTRAMEDULLARY NAIL FOR TIBIAL NON-INFECTIOUS DEFECT ]? ### Response:
Bone transportation by ring type external fixator combined with locked intramedullary nail could increase stability of extremities, allow early removal of external fixator and avoid axis shift of extremities, so it has good effect in treating tibial noninfectious defect.
### Instruction: Do cancer-associated fibroblasts promote the progression of endometrial cancer via the SDF-1/CXCR4 axis? ### Response:
Our data indicated that CAFs derived from EC tissues promoted EC progression via the SDF-1/CXCR4 axis in a paracrine- or autocrine-dependent manner. SDF-1α is a novel independent poor prognostic factor for EC patients' survival. Targeting the SDF-1/CXCR4 axis might provide a novel therapeutic strategy for EC treatment.
### Instruction: Is receipt of Care Discordant with Practice Guidelines Associated with Compromised Overall Survival in Nasopharyngeal Carcinoma? ### Response:
Many patients with stages I and IVC nasopharyngeal carcinoma do not receive care in accordance with practice guidelines. Receiving guidelines-discordant care is associated with compromised overall survival in the USA.
### Instruction: Is carotid Intima-Media Thickness Associated with Markers of Atherosclerosis in Stroke Patients? ### Response:
In our patients, carotid IMT does not seem to be associated with unequivocal markers of atheromatosis such as the existence of relevant carotid plaques or pathological ABI. These results as well as the association of IMT with age, hypertension, microalbuminuria, and mean waist perimeter support the hypothesis that IMT must be considered a risk factor for general vascular disease rather than a marker of atherosclerotic burden.
### Instruction: Does a non-invasive magnetic resonance imaging-based model predict portal venous pressure? ### Response:
The MRI-based formula has great potential for detecting portal hypertension. As a non-invasive measurement, it may be clinically accepted for the replacement of invasive modalities after further refinement.
### Instruction: Does foxO3 inactivation promote human cholangiocarcinoma tumorigenesis and chemoresistance through Keap1-Nrf2 signaling? ### Response:
Our results unravel a unique mechanism underlying the tumor suppressor function of FoxO3 through constraining Nrf2 signaling. (Hepatology 2016;63:1914-1927).
### Instruction: Does head-Elevated Patient Positioning decrease Complications of Emergent Tracheal Intubation in the Ward and Intensive Care Unit? ### Response:
Placing patients in a back-up head-elevated position, compared with supine position, during emergency tracheal intubation was associated with a reduced odds of airway-related complications.
### Instruction: Does joint instability lead to long-term alterations to knee synovium and osteoarthritis in a rabbit model? ### Response:
BTX-A induced joint instability in a muscle weakness model uniquely leads to alterations in gene expression and histological changes in the synovial membranes and cartilage in otherwise intact knee joints. These results lead to the conclusion that joint instability may promote an inflammatory intraarticular milieu, thereby contributing to the development of OA.
### Instruction: Are high levels of EGFR expression in tumor stroma associated with aggressive clinical features in epithelial ovarian cancer? ### Response:
High expression of EGFR in tumor stroma correlates with aggressive clinical features in epithelial ovarian cancer, and is an independent prognostic factor.
### Instruction: Is annual decline in forced expiratory volume steeper in aluminum potroom workers than in workers without exposure to potroom fumes? ### Response:
Aluminum potroom operators have increased annual decline in FEV1 relative to a comparable group with non-exposure to potroom fumes and gases.
### Instruction: Does a simple heated-capillary modification improve the analysis of non-covalent complexes by Z-spray electrospray ionization? ### Response:
The heated capillary minimizes in-source activation processes that can lead to unintended dissociation of complexes and perturbation of biomolecular structure, which rely on the integrity of non-covalent interactions. This effect can be attributed to the attenuation of the supersonic expansion typical of the Z-spray geometry and the greater ability to control the energy imparted to the system. This hardware modification will be expected to benefit the analysis of biomolecular structure performed on this particular instrumental platform.
### Instruction: Does initial varus displacement of proximal humerus fractures result in similar function but higher complication rates? ### Response:
In this study, initial surgical neck displacement in varus or valgus was found to not significantly affect functional outcome. Based upon our findings, patients with varus displaced proximal humerus fractures are at a greater risk of developing postoperative complications than those who present with initial valgus displaced fracture patterns.
### Instruction: Does a Human Open Field Test reveal Thigmotaxis Related to Agoraphobic Fear? ### Response:
This study is the first to our knowledge to verify the translational validity of the OFT and to reveal that thigmotaxis, an evolutionarily adaptive behavior shown by most species, is related to agoraphobia, a pathologic fear of open spaces, and anxiety sensitivity, a risk factor for agoraphobia.
### Instruction: Does fetal thymus size in human pregnancies reveal inverse association with regulatory T cell frequencies in cord blood? ### Response:
Fetal thymus growth is significantly correlated with fetal weight (GA 23-25 weeks r=0.40, p<0.01; GA 28-30 weeks r=0.21, p=0.04, GA 35-37 weeks r=0.56, p<0.01). We observed an inverse correlation between fetal thymus size at GA 23-25 weeks and cord blood Treg cells (r=0.37, p=0.01). Thymus growth occurs in a linear fashion throughout pregnancy and can be reliably measured using ultrasound. Our findings of an inverse correlation between thymus growth and Treg cells in cord blood suggests a link between fetal growth, thymus development and immune-status at birth.
### Instruction: Does distribution of Dengue Virus type 1 and 4 in Blood Components from Infected Blood Donors from Puerto Rico? ### Response:
DENV was present in all tested components from most donors, and viral RNA was not preferentially distributed in any of the tested components. Infectious DENV was also present in similar proportions in cultured plasma, clot and CCWB samples, indicating that these components may serve as a resource when sample sizes are limited. However, these results suggest that the sensitivity of the nucleic acid tests (NAT) for these viruses would not be improved by testing whole blood or components other than plasma.
### Instruction: Does upregulation of heme oxygenase-1 by ginsenoside Ro attenuate lipopolysaccharide-induced inflammation in macrophage cells? ### Response:
GRo induces anti-inflammatory effects following treatment with LPS via upregulation of HO-1.
### Instruction: Do personality Traits of Suicidality Are Associated with Premenstrual Syndrome and Premenstrual Dysphoric Disorder in a Suicidal Women Sample? ### Response:
This study demonstrates a strong, independent association between PMS/PMDD and trait anger among a representative sample of female suicide attempters. It is of major interest for clinicians in view of addressing a substantial public health problem among women of reproductive age.
### Instruction: Does genetic Variant in ACVR2B be Associated with Lean Mass? ### Response:
Our findings support a previously proposed role of ACVR2B allelic variation as a determinant of muscle mass and extend prior findings in men and women. Additional large-scale studies will be needed to confirm our findings in different populations.
### Instruction: Does rhoA/Rho-kinase activation promote lung fibrosis in an animal model of systemic sclerosis? ### Response:
Our findings confirm HOCl-induced pulmonary inflammation and fibrosis in mice, and provide further evidence for a key role of RhoA/ROCK pathway in several pathological processes of experimental SSc. Fasudil could be a promising therapeutic approach for the treatment of SSc.
### Instruction: Do predictors of Human Papillomavirus Vaccination Among Young Men Who Have Sex With Men? ### Response:
Findings highlight potential disparities in HPV vaccine uptake, as well as disparities in provider recommendation practices for HPV vaccination. Future interventions should aim to clarify misconceptions, modify psychosocial beliefs, and address barriers and facilitators to HPV vaccine uptake specific to young MSM.
### Instruction: Is non-alcoholic Fatty Liver Disease ( NAFLD ) associated with impairment of Health Related Quality of Life ( HRQOL )? ### Response:
NAFLD causes impairment of HRQOL. As NAFLD is becoming the most important cause of CLD, its clinical and PRO impact must be assessed.
### Instruction: Is the presence of fructosamine in human aortic valves associated with valve stiffness? ### Response:
Although no direct causativeness is proven with the presented results, which just show an association between fructosamine, the effect of FN3K and aortic valve stiffness, the present study points for the first time towards a possible additional role of the Amadori products in the biomechanical properties of ageing aortic valves.
### Instruction: Does fully automated open-source lesion mapping of T2-FLAIR images with FSL correlate with clinical disability in MS? ### Response:
Our T2LV quantification software produces T2LVs from a single FLAIR image that correlate with physical disability in MS and is freely available as open-source software.
### Instruction: Does selective Targeting of a Novel Epsin-VEGFR2 Interaction promote VEGF-Mediated Angiogenesis? ### Response:
Distinct residues in the epsin UIM and VEGFR2 mediate specific interactions between epsin and VEGFR2, in addition to UIM recognition of ubiquitin moieties on VEGFR2. These novel interactions are critical for pathophysiological angiogenesis, suggesting that these sites could be selectively targeted by therapeutics to modulate angiogenesis.
### Instruction: Does y-chromosome phylogeographic analysis of the Greek-Cypriot population reveal elements consistent with Neolithic and Bronze Age settlements? ### Response:
Analyses of Cypriot haplogroup data are consistent with two stages of prehistoric settlement. E-V13 and E-M34 are widespread, and PCA suggests sourcing them to the Balkans and Levant/Anatolia, respectively. The persistent pre-Greek component is represented by elements of G2-U5(xL30) haplogroups: U5*, PF3147, and L293. J2b-M205 may contribute also to the pre-Greek strata. The majority of R1b-Z2105 lineages occur in both the westernmost and easternmost districts. Distinctively, sub-haplogroup R1b- M589 occurs only in the east. The absence of R1b- M589 lineages in Crete and the Balkans and the presence in Asia Minor are compatible with Late Bronze Age influences from Anatolia rather than from Mycenaean Greeks.
### Instruction: Is high Single-dose Vancomycin Loading Associated With Increased Nephrotoxicity in Emergency Department Sepsis Patients? ### Response:
Initial dosing of vancomycin > 20 mg/kg was not associated with an increased rate of nephrotoxicity compared with lower doses. Findings from this study support compliance with initial weight-based vancomycin loading doses.
### Instruction: Does o-012 The Intestinal Wound Regeneration modulate Mucosal Microenvironment to Stimulate Expansion of a Local Pro-restitutive Microbiota? ### Response:
These findings highlight a novel role of FPR1 to promote changes in the wound microenvironment to such extent that enriches a specific mucosa-associated bacterium to enhance enterocyte migration and proliferation in an FPR1-mediated and redox-dependent fashion.
### Instruction: Does genetic Variation in NFKBIE be Associated With Increased Risk of Pneumococcal Meningitis in Children? ### Response:
A NFKBIE polymorphism was associated with increased risk of pneumococcal meningitis.
### Instruction: Does urinary LRRK2 phosphorylation predict parkinsonian phenotypes in G2019S LRRK2 carriers? ### Response:
Elevated ratio of phosphorylated Ser-1292 LRRK2 to total LRRK2 in urine exosomes predicted LRRK2 mutation status and PD risk among LRRK2 mutation carriers. Future studies may explore whether interventions that reduce this ratio may also reduce PD risk.
### Instruction: Does standardized EEG interpretation accurately predict prognosis after cardiac arrest? ### Response:
Highly malignant EEG after rewarming reliably predicted poor outcome in half of patients without false predictions. An isolated finding of a single malignant feature did not predict poor outcome whereas a benign EEG was highly predictive of a good outcome.
### Instruction: Is oct-4 associated with gastric cancer progression and prognosis? ### Response:
Oct-4 protein is a useful marker in predicting tumor progression and prognosis.
### Instruction: Does effectiveness of hand hygiene depend on the patient 's health condition and care environment? ### Response:
Patient hand contamination is affected by underlying disease and care environment, but can be reduced by encouraging proper hand washing. Proper patient hand hygiene can reduce MRSA on patients' hands, and thus may serve as an effective tool for prevention of healthcare-associated infections.
### Instruction: Does p38/JNK signaling pathway mediate the fluoride-induced down-regulation of Fam83h? ### Response:
The findings suggest that JNK and P38 could be key regulatory element for Fam83h expression, and that LS8 cells can respond to fluoride by down-regulating Fam83h expression through the regulation of JNK and p38 signaling pathways.
### Instruction: Does lung density associate with survival in alpha 1 antitrypsin deficient patients? ### Response:
Rate of change in lung densitometry could predict survival in A1ATD.
### Instruction: Do a Comparison of the Effect Between Coronoid Process Graft and Costochondral Graft in the Reconstruction of Temporomandibular Joint? ### Response:
CPG has higher frequency of a malocclusion secondary to resorption than CCG for the ramus reconstruction.
### Instruction: Does transthoracic Echocardiography provide Important Long-Term Prognostic Information in Selected Patients Undergoing Endovascular Abdominal Aortic Repair? ### Response:
Echocardiography provides important long-term prognostic information in patients undergoing endovascular aneurysm repair. These TTE indices were more important at predicting outcome than standard conventional risk factors in this patient group. A greater tubular ascending aorta, presence of mitral regurgitation, reduced left ventricular ejection fraction, younger age, and diabetes mellitus were independently associated with long-term mortality.
### Instruction: Does follicular thyroid carcinoma but not adenoma recruit tumor-associated macrophages by releasing CCL15? ### Response:
Our study suggested FTC might induce TAMs infiltration by producing CCL15. Measurement of TAMs and CCL15 in follicular thyroid lesions may be applied clinically to differentiate FTC from FA pre-operation.
### Instruction: Are males seropositive for hepatitis B surface antigen at risk of lower bone mineral density : the 2008-2010 Korea National Health and Nutrition Examination Surveys? ### Response:
HBsAg seropositivity was significantly associated with lower BMD in male. Future long-term prospective studies investigating bone turnover markers and hormones are needed to better understand the pathophysiology and clinical significance of chronic hepatitis B virus-related hepatic osteodystrophy.
### Instruction: Does mOLECULAR CHARACTERISATION AND ANTIMICROBIAL RESISTANCE PATTERNS OF ESCHERICHIA COLI isolate FROM GOATS SLAUGHTERED IN PARTS OF KENYA? ### Response:
This study demonstrated that there is a significant level of antimicrobial resistance in pathogenic E. coli isolated from goat meat from Huruma and Kiserian abattoir. This indicates that goat meat from abattoirs could pose a risk of transmission of pathogenic antibiotic resistant strains to human. Poor hygienic standards and indiscriminate use of antimicrobials are the two main reasons for the presence of resistant pathogens in goat carcasses.
### Instruction: Does antroduodenal Manometry be Abnormal in Children Presenting With Orthostatic Intolerance and Gastrointestinal Symptoms? ### Response:
ADM is frequently abnormal in children with OI and GI symptoms. Upper GI motility studies should be a part of the comprehensive evaluation in this population.
### Instruction: Is higher Mortality in Surgically Managed Diverticulitis Associated with Asian Ethnicity and Right-Sided Disease? ### Response:
The ethnicity variable was not uniformly collected by all states within the Nationwide Inpatient Sample database.
### Instruction: Does molecular characterization of HCV in a Swedish county over 8 years ( 2002-2009 ) reveal distinct transmission patterns? ### Response:
We found different transmission patterns in D-county which may, from a public health perspective, have implications for how to control virus infections by targeted interventions.
### Instruction: Does uCA1 overexpression predict clinical outcome of patients with ovarian cancer receiving adjuvant chemotherapy? ### Response:
Our findings provided the first evidence that UCA1 may serve as an indicator of response to chemotherapy and prognosis of ovarian cancer. UCA1 may play an important role in the progression of ovarian cancer.
### Instruction: Do immediate effect of vibratory stimuli on quadriceps function in healthy adults? ### Response:
WBV and LMV increased quadriceps function and may be used to enhance the efficacy of strengthening protocols. Muscle Nerve 54: 469-478, 2016.
### Instruction: Do genome-wide studies reveal novel and distinct biological pathways regulated by SIN3 isoforms? ### Response:
These data establish the role of SIN3 isoforms in regulating distinct biological processes. This study substantially contributes to our understanding of the complexity of gene regulation by SIN3.
### Instruction: Is elevated TNF-α associated with pain and physical disability in mucopolysaccharidosis types I , II , and VI? ### Response:
Higher TNF-α levels are implicated in the pain and decreased physical function present in individuals with MPS despite treatment with ERT and/or HCT, suggesting that TNF-a inhibition could potentially be a useful adjunctive therapy. Further investigation into the role of TNF-α inhibition in MPS to decrease pain and improve physical function is indicated.
### Instruction: Is migraine related to an increased risk of Parkinson 's disease : A population-based , propensity score-matched , longitudinal follow-up study? ### Response:
This study showed an increased risk of developing PD in patients with migraine.
### Instruction: Is mutation pattern an influential factor on functional mutation rates in cancer? ### Response:
Somatic mutation densities vary largely across cancer genome, mutation frequency is a major indication of function and influence on the distribution of functional mutations in cancer.
### Instruction: Does aggregatibacter actinomycetemcomitans-Induced AIM2 Inflammasome Activation be Suppressed by Xylitol in Differentiated THP-1 Macrophages? ### Response:
A. actinomycetemcomitans induced IL-1β production and AIM2 inflammasome activation. Xylitol inhibited these effects, possibly by suppressing internalization of A. actinomycetemcomitans into cells. Thus, this study proposes a mechanism for IL-1β production via inflammasome activation and discusses a possible use for xylitol in periodontal inflammation caused by A. actinomycetemcomitans.
### Instruction: Is strain echocardiography related to fibrosis and ventricular arrhythmias in hypertrophic cardiomyopathy? ### Response:
GLS, mechanical dispersion, and LGE were markers of VAs in HCM patients. Mechanical dispersion was a strong independent predictor of VAs and related to the extent of fibrosis. Strain echocardiography may improve risk stratification of VAs in HCM.
### Instruction: Does genome-wide association study in mice identify loci affecting liver-related phenotypes including Sel1l influencing serum bile acids? ### Response:
Genetic analyses of inbred mouse strains identified loci affecting different liver-related traits and implicated Sel1l as a significant determinant of serum bile acid concentration. (Hepatology 2016;63:1943-1956).
### Instruction: Does platelet activation independent of pulmonary inflammation contribute to diesel exhaust particulate-induced promotion of arterial thrombosis? ### Response:
DEP accelerates arterial thrombus formation through increased platelet activation. This effect is dissociated from pulmonary and systemic inflammation and from impaired fibrinolytic function.
### Instruction: Does gaAlAs laser-induced pulp mineralization involve dentin matrix protein 1 and osteopontin expression? ### Response:
GaAlAs laser irradiation of rat molars induced upregulated DMP1 and osteopontin mRNA expression in the coronal pulp, followed by the formation of reparative dentin and the colocalization of DMP1 and osteopontin immunoreactivity at the site at which this tissue first appeared.
### Instruction: Does caffeine prevent Hyperoxia-Induced Functional and Structural Lung Damage in Preterm Rabbits? ### Response:
In preterm rabbits, caffeine reduces the functional, architectural and inflammatory pulmonary changes induced by hyperoxia in the lung.
### Instruction: Do stimulated echo diffusion weighted imaging of the liver at 3 Tesla? ### Response:
The results verified the Δ dependence in diffusion measurements, indicating restricted diffusion in healthy human livers for the first time at 3T. This prepared STEAM DWI a potential technique for liver fibrotic studies in clinical practice. Magn Reson Med, 2016. © 2016 Wiley Periodicals, Inc.
### Instruction: Are nailfold videocapillaroscopy and serum VEGF levels in scleroderma associated with internal organ involvement? ### Response:
Our data suggest the importance of NVC not only for the diagnosis, but also for the global evaluation of SSc patients. Of note, serum VEGF levels may act as a biomarker of interstitial lung involvement.
### Instruction: Is aNGPTL8/Betatrophin R59W variant associated with higher glucose level in non-diabetic Arabs living in Kuwaits? ### Response:
Our data shows for the first time that heterozygote form of ANGPTL8 Rs.2278426 variant was associated with higher FBG level in Arabs highlighting the importance of these variants in controlling the function of betatrophin.
### Instruction: Are early detection of type 2 diabetes mellitus and screening for retinopathy associated with reduced prevalence and severity of retinopathy? ### Response:
Among patients with screening-detected diabetes, the prevalence of retinopathy and increasing severity of retinopathy were significantly lower than among those who had their diabetes diagnosed through conventional care, even when other risk factors for retinopathy such as duration, hyperglycaemia and blood pressure were considered. Early detection of diabetes reduces prediagnostic time spent with hyperglycaemia. In combination with early and regular screening for retinopathy, more effective prevention against retinopathy can be provided.
### Instruction: Is tGF-β signaling activated in patients with chronic HBV infection and repressed by SMAD7 overexpression after successful antiviral treatment? ### Response:
SMAD7 overexpression might represent a mechanism limiting TGF-β-mediated fibrogenesis in human hepatic diseases; therefore, SMAD7 induction likely represents a candidate for novel therapeutic approaches.
### Instruction: Is the proteolytic activity of pregnancy-associated plasma protein-A potentially regulated by stanniocalcin-1 and -2 during human ovarian follicle development? ### Response:
The STCs and PAPP-A show similar expression by immunohistochemistry in developing follicles, and regulation of PAPP-A proteolytic activity is suggested by the identification of inhibited protein complexes between PAPP-A and STC1 or STC2 in human follicular fluid (FF).
### Instruction: Does transportome Profiling identify Profound Alterations in Crohn 's Disease Partially Restored by Commensal Bacteria? ### Response:
These results describe the altered transportome profile in CD and open the possibility of restoring transportome complications with commensal bacteria.
### Instruction: Does implantation of healthy matrix-embedded endothelial cells rescue dysfunctional endothelium and ischaemic tissue in liver engraftment? ### Response:
Implants with healthy endothelial cells rescue liver donor and recipient endothelium and parenchyma from ischaemic injury after major hepatectomy and engraftment. This study highlights endothelial-hepatocyte crosstalk in hepatic repair and provides a promising new approach to improve regenerative medicine outcomes and liver transplantation.
### Instruction: Does maternal periodontitis decrease plasma membrane GLUT4 content in skeletal muscle of adult offspring? ### Response:
Maternal periodontal disease causes LBW, insulin resistance, and alterations in the final stage of insulin signaling in the GSM of adult offspring.
### Instruction: Does a Live Vector Expressing HPV16 L1 generate an Adjuvant-Induced Antibody Response In-vivo? ### Response:
The recombinant live vector was able to induce humoral immunity in mice without need of any adjuvant. However, further studies have required to increase its efficiency.
### Instruction: Do human classical monocytes display unbalanced M1/M2 phenotype with increased atherosclerotic risk and presence of disease? ### Response:
We conclude that monocyte subsets show functional and phenotypic changes in cardiovascular disease and such changes are likely to contribute to atherosclerotic progression.
### Instruction: Do [ The Relationship Between the Damages of Hand Functions and the Type of Cerebral Palsy in Children ]? ### Response:
There was a correlation between the MACS and the type of CP which can be used to determine the damaged condition of hand functions and develop the program of rehabilitation and the measures of classification management for the chidren with CP.
### Instruction: Are serum fetuin-A levels independently correlated with vascular endothelial growth factor and C-reactive protein concentrations in type 2 diabetic patients with diabetic retinopathy? ### Response:
Serum fetuin-A concentrations are independently correlated with VEGF and CRP concentrations in T2DM patients with DR, but not in NDR subjects.
### Instruction: Is arterial Blood , Rather Than Venous Blood , a Better Source for Circulating Melanoma Cells? ### Response:
Our data indicate that arterial blood specimens might be a better source of circulating uveal melanoma cells. Although less conveniently processed, perhaps arterial blood should be evaluated as sample source for measurement of CTCs.
### Instruction: Does multicomponent Fitness Training improve Walking Economy in Older Adults? ### Response:
Multicomponent fitness training decreases walking cost in older adults, preserving walking economy. Thus, training programs could delay mobility limitation with increasing age.