UnsolvedBiology / sets.json
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Release v1.4: 18,000 domain-pure problems (1,125 x 16 categories), 100% real authors & journals, problem-specific scales/systems/difficulty, and 5 references per problem
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[
{
"id": 1,
"name": "plant_science_100_questions_2023",
"display_name": "Plant Science, Photosynthesis, and Botanical Mechanisms",
"description": "Open questions in plant biology anchored by Armstrong et al. (2023, New Phytologist, '100 Important Questions Facing Plant Science'), The Plant Cell and Journal of Experimental Botany Open Questions, and peer-reviewed plant physiology, development, and immunity studies.",
"slug": "plant-science-100-questions-2023",
"order_index": 1,
"created_at": "2026-10-14T00:00:00Z"
},
{
"id": 2,
"name": "fundamental_ecology_100_questions",
"display_name": "Fundamental Ecology, Biodiversity, and Ecosystem Dynamics",
"description": "Open problems in community, population, and ecosystem ecology anchored by Sutherland et al. (2013, Journal of Ecology, '100 Fundamental Ecological Questions') and peer-reviewed biodiversity, trophic network, and global change ecology literature.",
"slug": "fundamental-ecology-100-questions",
"order_index": 2,
"created_at": "2026-10-14T00:00:00Z"
},
{
"id": 3,
"name": "royal_society_open_biology_questions",
"display_name": "Molecular, Cellular, and Biochemical Mechanisms",
"description": "Open mechanistic questions in cell biology, organelle dynamics, enzyme catalysis, structural biophysics, and macromolecular assemblies anchored by the Royal Society Open Biology 'Open Questions' series and peer-reviewed molecular biology literature.",
"slug": "royal-society-open-biology-questions",
"order_index": 3,
"created_at": "2026-10-14T00:00:00Z"
},
{
"id": 4,
"name": "openbiorq_mechanism_core",
"display_name": "Genetics, Epigenomics, and Disease Pathogenesis Core",
"description": "Mechanistic open questions in genome regulation, chromatin architecture, RNA biology, and molecular disease pathogenesis curated from the OpenBioRQ biomedical corpus and peer-reviewed genetics and pathobiology literature.",
"slug": "openbiorq-mechanism-core",
"order_index": 4,
"created_at": "2026-10-14T00:00:00Z"
},
{
"id": 5,
"name": "conservation_physiology_100_questions",
"display_name": "Organismal Physiology, Homeostasis, and Integrative Systems",
"description": "Open questions in systemic physiology, neuroendocrine homeostasis, and multiscale biophysical organization anchored by Cooke et al. (2021, Conservation Physiology) and peer-reviewed physiological and systems biology syntheses.",
"slug": "conservation-physiology-100-questions",
"order_index": 5,
"created_at": "2026-10-14T00:00:00Z"
},
{
"id": 6,
"name": "fungal_dispersal_ecology_100_questions",
"display_name": "Fungal Biology, Mycology, and Mycorrhizal Symbiosis",
"description": "Open mechanistic and ecological questions in fungal cell biology, hyphal morphogenesis, mycotoxin biosynthesis, fungal pathogenesis, and mycorrhizal symbiosis anchored by Aguilar-Trigueros et al. and peer-reviewed mycological literature.",
"slug": "fungal-dispersal-ecology-100-questions",
"order_index": 6,
"created_at": "2026-10-14T00:00:00Z"
},
{
"id": 7,
"name": "livestock_helminthology_100_questions",
"display_name": "Parasitology, Protozoology, and Host-Parasite Biology",
"description": "Open questions on protozoan and helminth biology, apicomplexan and kinetoplastid host invasion, vector transmission, and antiparasitic resistance anchored by Morgan et al. (2019, Trends in Parasitology) and peer-reviewed parasitology literature.",
"slug": "livestock-helminthology-100-questions",
"order_index": 7,
"created_at": "2026-10-14T00:00:00Z"
},
{
"id": 8,
"name": "fish_migration_100_questions",
"display_name": "Evolutionary Biology, Speciation, and Adaptive Radiation",
"description": "Open problems in natural selection, speciation, phylogenomics, life-history evolution, and adaptive plasticity anchored by Lennox et al. (2019, Frontiers in Ecology and Evolution) and peer-reviewed evolutionary biology literature.",
"slug": "fish-migration-100-questions",
"order_index": 8,
"created_at": "2026-10-14T00:00:00Z"
},
{
"id": 9,
"name": "neuroscience_cell_molecular_challenges",
"display_name": "Neuroscience, Behavior, Development, and Aging Challenges",
"description": "Open questions in neural circuit computation, synaptic plasticity, behavior, embryonic morphogenesis, stem cell regeneration, and organismal aging anchored by Adolphs (2015, Trends in Cognitive Sciences) and peer-reviewed neurobiology and developmental biology syntheses.",
"slug": "neuroscience-cell-molecular-challenges",
"order_index": 9,
"created_at": "2026-10-14T00:00:00Z"
},
{
"id": 10,
"name": "microbiology_virology_immunity_questions",
"display_name": "Microbiology, Virology, and Host Immunity Questions",
"description": "Open mechanistic problems on bacterial and archaeal physiology, microbiome dynamics, phage-bacteria interactions, viral replication and latency, and innate and adaptive immunity across peer-reviewed microbiology, virology, and immunology literature.",
"slug": "microbiology-virology-immunity-questions",
"order_index": 10,
"created_at": "2026-10-14T00:00:00Z"
}
]