Update README.md

README.md

@@ -35,3 +35,27 @@ configs:
   - split: test
     path: data/test-*
 ---
+
+# STRING PPI Human 1M
+
+This dataset contains 1 million human protein–protein interactions (PPIs) derived from STRING v11.5.
+
+**Columns**:
+- `seq_a`, `seq_b`: Amino acid sequences of the interacting proteins (≤2048 AA).
+- `seq_name_a`, `seq_name_b`: Protein names from STRING.
+- `score`: Combined score from STRING (0–1000, normalized to 0–1). This score integrates various evidence channels (experimental data, text mining, co-expression, etc.) into a single confidence metric.
+- `label`: Binary interaction label.
+  - `1`: High-confidence positive interaction (STRING experimental score > 0.7).
+  - `0`: Low-confidence negative interaction (STRING experimental score < 0.2).
+
+**Processing Steps**:
+- Downloaded human interactions from STRING (`9606.protein.links.detailed.v11.5.txt.gz`).
+- Filtered by experimental score thresholds for positives/negatives.
+- Retrieved protein sequences from UniProt by matching STRING protein names.
+- Excluded sequences longer than 2048 amino acids.
+- Balanced top and bottom 500k interactions by combined score.
+
+Useful for training models for binary PPI prediction or embedding-based methods.
+
+Source: [STRING Database v11.5](https://string-db.org).
+